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Search of human proteins with 4885215
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885215 v-erb-a erythroblastic leukemia viral oncogene
homolog 4 isoform JM-a/CVT-1 precursor [Homo sapiens]
(1308 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 2750 0.0
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 2705 0.0
gi|29725609 epidermal growth factor receptor isoform a precursor... 1263 0.0
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 1206 0.0
gi|54792096 erbB-2 isoform a [Homo sapiens] 1131 0.0
gi|54792098 erbB-2 isoform b [Homo sapiens] 1120 0.0
gi|41327736 epidermal growth factor receptor isoform d precursor... 631 e-180
gi|41327732 epidermal growth factor receptor isoform b precursor... 631 e-180
gi|41327734 epidermal growth factor receptor isoform c precursor... 390 e-108
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 226 8e-59
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 220 6e-57
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 220 6e-57
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 214 3e-55
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 214 3e-55
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 214 3e-55
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 213 7e-55
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 213 1e-54
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 213 1e-54
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 213 1e-54
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 213 1e-54
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 213 1e-54
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 211 4e-54
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 211 4e-54
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 211 5e-54
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 209 1e-53
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 209 1e-53
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 206 1e-52
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 206 2e-52
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 205 3e-52
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 205 3e-52
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 2750 bits (7129), Expect = 0.0
Identities = 1308/1308 (100%), Positives = 1308/1308 (100%)
Query: 1 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM
Sbjct: 1 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
Query: 61 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF
Sbjct: 61 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
Query: 121 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST
Sbjct: 121 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
Query: 181 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG
Sbjct: 181 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
Query: 241 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD
Sbjct: 241 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
Query: 301 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT
Sbjct: 301 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
Query: 361 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL
Sbjct: 361 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
Query: 421 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 480
VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST
Sbjct: 421 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 480
Query: 481 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 540
INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD
Sbjct: 481 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 540
Query: 541 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 600
GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA
Sbjct: 541 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 600
Query: 601 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 660
NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG
Sbjct: 601 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 660
Query: 661 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 720
LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR
Sbjct: 661 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 720
Query: 721 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL
Sbjct: 721 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV
Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ
Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
Query: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID
Sbjct: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
Query: 961 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE
Sbjct: 961 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP 1080
EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP
Sbjct: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP 1080
Query: 1081 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1140
YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS
Sbjct: 1081 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1140
Query: 1141 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1200
PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED
Sbjct: 1141 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1200
Query: 1201 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1260
EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ
Sbjct: 1201 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1260
Query: 1261 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1308
EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
Sbjct: 1261 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1308
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 2705 bits (7012), Expect = 0.0
Identities = 1292/1308 (98%), Positives = 1292/1308 (98%), Gaps = 16/1308 (1%)
Query: 1 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM
Sbjct: 1 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
Query: 61 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF
Sbjct: 61 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
Query: 121 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST
Sbjct: 121 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
Query: 181 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG
Sbjct: 181 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
Query: 241 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD
Sbjct: 241 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
Query: 301 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT
Sbjct: 301 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
Query: 361 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL
Sbjct: 361 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
Query: 421 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 480
VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST
Sbjct: 421 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 480
Query: 481 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 540
INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD
Sbjct: 481 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 540
Query: 541 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 600
GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA
Sbjct: 541 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 600
Query: 601 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 660
NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG
Sbjct: 601 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 660
Query: 661 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 720
LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR
Sbjct: 661 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 720
Query: 721 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL
Sbjct: 721 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV
Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ
Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
Query: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID
Sbjct: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
Query: 961 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE
Sbjct: 961 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP 1080
EYLVPQAFNIPPPIYTSRARIDSNR NQFVYRDGGFAAEQGVSVP
Sbjct: 1021 EYLVPQAFNIPPPIYTSRARIDSNR----------------NQFVYRDGGFAAEQGVSVP 1064
Query: 1081 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1140
YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS
Sbjct: 1065 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1124
Query: 1141 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1200
PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED
Sbjct: 1125 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1184
Query: 1201 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1260
EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ
Sbjct: 1185 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1244
Query: 1261 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1308
EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
Sbjct: 1245 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1292
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 1263 bits (3269), Expect = 0.0
Identities = 645/1267 (50%), Positives = 817/1267 (64%), Gaps = 99/1267 (7%)
Query: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
Query: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
Query: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
Query: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
Query: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
Query: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
Query: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
+DP++L++ +TV+EITGFL IQ+WP N TD F NL I GR G L +
Sbjct: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443
Query: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
ITSL +SLKEIS G++ I+ N NLCY +TINW LF T Q+ I NR +C A G
Sbjct: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503
Query: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
VC+ LCS +GCWGP P C+SCR SRGR C++ CNL +GE REF S C++C P+C
Sbjct: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563
Query: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANS-FIFKYADPDRECHPCHP 619
+ TC G GPDNC +C+H+ DGP+CV+ CP G+ G N+ ++KYAD CH CHP
Sbjct: 564 PQAMNI-TCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622
Query: 620 NCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKS 679
NCT GC GP C P G + P IA G++G L +L++V L +++RR+
Sbjct: 623 NCTYGCTGPGLEGC---PTNG-------PKIPSIATGMVGALLLLLVVALGIGLFMRRRH 672
Query: 680 IKKKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWV 738
I +KR LRR L E ELVEPLTPSG APNQA LRILKETE K++KVLGSGAFGTVYKG+W+
Sbjct: 673 IVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWI 732
Query: 739 PEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQL 798
PEGE VKIPVAIK L E T PKAN E +DEA +MAS+D+PH+ RLLG+CL+ T+QL+TQL
Sbjct: 733 PEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQL 792
Query: 799 MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVK 858
MP GCLL+YV EHKDNIGSQ LLNWCVQIAKGM YLE+RRLVHRDLAARNVLVK+P HVK
Sbjct: 793 MPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK 852
Query: 859 ITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGG 918
ITDFGLA+LL +EKEY+A+GGK+PIKWMALE I +R +THQSDVWSYGVT+WELMTFG
Sbjct: 853 ITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 912
Query: 919 KPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMA 978
KPYDGIP EI +LEKGERLPQPPICTIDVYM+MVKCWMIDADSRPKF+EL EFS+MA
Sbjct: 913 KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMA 972
Query: 979 RDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSR 1038
RDPQRYLVIQGD+RM LPSP DS F++ L+DEED++D++DA+EYL+PQ P TSR
Sbjct: 973 RDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSP-STSR 1031
Query: 1039 ARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGAT 1098
+ S+ S ++ A +G Q
Sbjct: 1032 TPLLSSLSATSNNSTVACIDRNGLQ----------------------------------- 1056
Query: 1099 AEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKP 1158
SC ++EDS QRYS+DPT G L E+ P
Sbjct: 1057 ------SC-----------PIKEDSFLQRYSSDPT---------GALTEDSIDDTF--LP 1088
Query: 1159 KQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGK 1218
EY+ N V +R G +Q NP YHN P + D P Y + + +G
Sbjct: 1089 VPEYI-----NQSVPKRPAGSVQ---NPVYHNQPLNPAPSRD-----PHYQDPHSTAVGN 1135
Query: 1219 AEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIV 1278
EYL P FD+P +W + +L +PDY Q++ K K NG +
Sbjct: 1136 PEYLNT---VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKE-AKPNGIFKGST 1191
Query: 1279 AENPEYL 1285
AEN EYL
Sbjct: 1192 AENAEYL 1198
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 1206 bits (3120), Expect = 0.0
Identities = 623/1181 (52%), Positives = 792/1181 (67%), Gaps = 47/1181 (3%)
Query: 1 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
M+ L V L A + +SQ+VC GT N LS D E QY+ L K YE CEVVM
Sbjct: 1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM 60
Query: 61 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
GNLEI HN DLSFL+ +REVTGYVLVA+N+F LPL NLR++RGT++Y+ ++A+ +
Sbjct: 61 GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM 120
Query: 121 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
LNY + + L++L L LTEIL+GGVY+++N LC+ DTI W+DIVR+ + +V
Sbjct: 121 LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVK 177
Query: 181 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
+ C CH+ C GRCWGP CQTLT+T+CA QC+G C+GP + CCH ECAGGCSG
Sbjct: 178 DNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSG 237
Query: 241 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
P+DTDCFAC +FNDSGACV +CPQ VYN TFQLE N + KY YG CV CPHNFVVD
Sbjct: 238 PQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVD 297
Query: 301 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
+SCVRACP KMEV++NG+KMC+PC +CPKAC+G G+GS QTVDSSNID F+NCT
Sbjct: 298 QTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRF--QTVDSSNIDGFVNCT 355
Query: 361 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
KI GNL FL+TG++GDP++ I A+DPEKLNVFRTVREITG+LNIQSWPP+M +FSVFSNL
Sbjct: 356 KILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNL 415
Query: 421 VTIGGRVLYS-GLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWT-TLF 478
TIGGR LY+ G SLLI+K +TSL F+SLKEISAG IYI+ N LCY+H++NWT L
Sbjct: 416 TTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLR 475
Query: 479 STINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNL 538
+R+ I+ NR +C AEG VC+ LCSS GCWGPGP QCLSCR +SRG +C+ CN
Sbjct: 476 GPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNF 535
Query: 539 YDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQ 598
+GE REF + + C C P+C+ ME G TC+G G D C +C+HF+DGP+CV CP G+
Sbjct: 536 LNGEPREFAHEAECFSCHPECQPME-GTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVL 594
Query: 599 GANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPL-IAAGV 657
GA I+KY D EC PCH NCTQGC GP DC+ TL +T L +A V
Sbjct: 595 GAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCL------GQTLVLIGKTHLTMALTV 648
Query: 658 IGGLFIL-VIVGLTFAVYVRRKSIKKKRALRRFLET-ELVEPLTPSGTAPNQAQLRILKE 715
I GL ++ +++G TF +Y R + I+ KRA+RR+LE E +EPL PS A N+ RI KE
Sbjct: 649 IAGLVVIFMMLGGTF-LYWRGRRIQNKRAMRRYLERGESIEPLDPSEKA-NKVLARIFKE 706
Query: 716 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM 775
TEL+++KVLGSG FGTV+KG+W+PEGE++KIPV IK++ + +G ++ D L + S+
Sbjct: 707 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 766
Query: 776 DHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE 835
DH H+VRLLG+C ++QLVTQ +P G LL++V +H+ +G QLLLNW VQIAKGM YLE
Sbjct: 767 DHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLE 826
Query: 836 ERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYR 895
E +VHR+LAARNVL+KSP+ V++ DFG+A LL D+K+ K PIKWMALE IH+
Sbjct: 827 EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFG 886
Query: 896 KFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVK 955
K+THQSDVWSYGVT+WELMTFG +PY G+ E+PDLLEKGERL QP ICTIDVYMVMVK
Sbjct: 887 KYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVK 946
Query: 956 CWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKL-PSPNDSKFFQNLLDEEDLE 1014
CWMID + RP FKELA EF+RMARDP RYLVI+ + + P P L+E +LE
Sbjct: 947 CWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELE 1006
Query: 1015 DMMDAEEYLVPQAFNIPPPIYTSRARI---DSNR---SEIGHSPPPAYTPMSGNQFVYRD 1068
+D + L + N+ S + NR S+ SP Y PM+
Sbjct: 1007 PELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNL---- 1062
Query: 1069 GGFAAEQGVS-----VPYRAPTSTIPEAPVAQ--------GATAEIFDD-SCCNGTLRKP 1114
G E VS P +P +A G+ AE+ + S C R
Sbjct: 1063 GESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSR 1122
Query: 1115 VAPHVQEDSS--TQRYSADPTVFAPERSPRGELDEEGYMTP 1153
+P + DS+ +QR+S V E D GY+ P
Sbjct: 1123 -SPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMP 1162
Score = 35.0 bits (79), Expect = 0.47
Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 5/90 (5%)
Query: 1165 PVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKN 1224
P E+ +++R+++G P A+ G A ++ E + Y +
Sbjct: 1256 PDEDYEYMNRQRDGG-----GPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARL 1310
Query: 1225 NILSMPEKAKKAFDNPDYWNHSLPPRSTLQ 1254
L E AFDNPDYW+ L P++ Q
Sbjct: 1311 KTLRSLEATDSAFDNPDYWHSRLFPKANAQ 1340
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 1131 bits (2925), Expect = 0.0
Identities = 601/1282 (46%), Positives = 789/1282 (61%), Gaps = 101/1282 (7%)
Query: 25 SQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVT 84
S VC GT+ KL + E LR Y+ C+VV GNLE+T + N LSFL+ ++EV
Sbjct: 22 STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQ 81
Query: 85 GYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNF---------GLQELG 135
GYVL+A NQ R +PL+ LRI+RGT+L+ED YALA+ N N GL+EL
Sbjct: 82 GYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ 141
Query: 136 LKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTG 195
L++LTEIL GGV + +N LCY DTI W+DI LTL+ TN S C C C G
Sbjct: 142 LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKG 201
Query: 196 -RCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFND 254
RCWG + CQ+LTRTVCA C RC GP +DCCH +CA GC+GPK +DC AC++FN
Sbjct: 202 SRCWGESSEDCQSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNH 260
Query: 255 SGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFV-VDSSSCVRACPSSKM 313
SG C CP YN TF+ N +YT+GA CV CP+N++ D SC CP
Sbjct: 261 SGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQ 320
Query: 314 EVE-ENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTG 372
EV E+G + C+ C+ C + C G+G L + V S+NI +F C KI G+L FL
Sbjct: 321 EVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES 380
Query: 373 IHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL 432
GDP + + PE+L VF T+ EITG+L I +WP ++ D SVF NL I GR+L++G
Sbjct: 381 FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGA 440
Query: 433 SLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRK 492
L L+ GI+ L +SL+E+ +G I N++LC+ HT+ W LF +Q ++ NR
Sbjct: 441 YSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRP 500
Query: 493 AENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSIC 552
+ C EG+ C+ LC+ CWGPGP QC++C +F RG+ C+E C + G RE+ N C
Sbjct: 501 EDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHC 560
Query: 553 VECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSF--IFKYADP 610
+ C P+C+ ++G +TC GP D C C+H+KD P CV +CP G++ S+ I+K+ D
Sbjct: 561 LPCHPECQP-QNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDE 619
Query: 611 DRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHAR----TPLIAAGVIGGLFILVI 666
+ C PC NCT C C P R T +I+A V G+ ++V+
Sbjct: 620 EGACQPCPINCTHSCVDLDDKGC-----------PAEQRASPLTSIISAVV--GILLVVV 666
Query: 667 VGLTFAVYVRRKSIK-KKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVL 724
+G+ F + ++R+ K +K +RR L ETELVEPLTPSG PNQAQ+RILKETEL++VKVL
Sbjct: 667 LGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVL 726
Query: 725 GSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLL 784
GSGAFGTVYKGIW+P+GE VKIPVAIK+L E T PKAN E +DEA +MA + P++ RLL
Sbjct: 727 GSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLL 786
Query: 785 GVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDL 844
G+CL+ T+QLVTQLMP+GCLL++V E++ +GSQ LLNWC+QIAKGM YLE+ RLVHRDL
Sbjct: 787 GICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDL 846
Query: 845 AARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVW 904
AARNVLVKSPNHVKITDFGLARLL+ DE EY+ADGGK+PIKWMALE I R+FTHQSDVW
Sbjct: 847 AARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVW 906
Query: 905 SYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSR 964
SYGVT+WELMTFG KPYDGIP REIPDLLEKGERLPQPPICTIDVYM+MVKCWMID++ R
Sbjct: 907 SYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECR 966
Query: 965 PKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLV 1024
P+F+EL +EFSRMARDPQR++VIQ +D + SP DS F+++LL+++D+ D++DAEEYLV
Sbjct: 967 PRFRELVSEFSRMARDPQRFVVIQNED-LGPASPLDSTFYRSLLEDDDMGDLVDAEEYLV 1025
Query: 1025 PQ-AFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQG---VSVP 1080
PQ F P P P +G +R + G +++
Sbjct: 1026 PQQGFFCPDP-----------------------APGAGGMVHHRHRSSSTRSGGGDLTLG 1062
Query: 1081 YRAPTSTIPEAPVA--QGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPE 1138
P +P+A +GA +++FD G + + + S QRYS DPTV P
Sbjct: 1063 LEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPS 1122
Query: 1139 RSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQA-------LDNPEYHN- 1190
+ +GY+ P+ P+ EY+N + P + G L A L+ P+ +
Sbjct: 1123 ET-------DGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSP 1175
Query: 1191 ASNGPPK---AEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSL 1247
NG K A V P YL + P AFDN YW+
Sbjct: 1176 GKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPH--------PPPAFSPAFDNLYYWDQDP 1227
Query: 1248 PPRS----------TLQHPDYL 1259
P R T ++P+YL
Sbjct: 1228 PERGAPPSTFKGTPTAENPEYL 1249
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 1120 bits (2898), Expect = 0.0
Identities = 596/1272 (46%), Positives = 783/1272 (61%), Gaps = 101/1272 (7%)
Query: 35 KLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQF 94
KL + E LR Y+ C+VV GNLE+T + N LSFL+ ++EV GYVL+A NQ
Sbjct: 2 KLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQV 61
Query: 95 RYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNF---------GLQELGLKNLTEILNG 145
R +PL+ LRI+RGT+L+ED YALA+ N N GL+EL L++LTEIL G
Sbjct: 62 RQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKG 121
Query: 146 GVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTG-RCWGPTENH 204
GV + +N LCY DTI W+DI LTL+ TN S C C C G RCWG +
Sbjct: 122 GVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSED 181
Query: 205 CQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQ 264
CQ+LTRTVCA C RC GP +DCCH +CA GC+GPK +DC AC++FN SG C CP
Sbjct: 182 CQSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPA 240
Query: 265 TFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFV-VDSSSCVRACPSSKMEVE-ENGIKM 322
YN TF+ N +YT+GA CV CP+N++ D SC CP EV E+G +
Sbjct: 241 LVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQR 300
Query: 323 CKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIE 382
C+ C+ C + C G+G L + V S+NI +F C KI G+L FL GDP +
Sbjct: 301 CEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA 360
Query: 383 AIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGI 442
+ PE+L VF T+ EITG+L I +WP ++ D SVF NL I GR+L++G L L+ GI
Sbjct: 361 PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI 420
Query: 443 TSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMV 502
+ L +SL+E+ +G I N++LC+ HT+ W LF +Q ++ NR + C EG+
Sbjct: 421 SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLA 480
Query: 503 CNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKM 562
C+ LC+ CWGPGP QC++C +F RG+ C+E C + G RE+ N C+ C P+C+
Sbjct: 481 CHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQP- 539
Query: 563 EDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSF--IFKYADPDRECHPCHPN 620
++G +TC GP D C C+H+KD P CV +CP G++ S+ I+K+ D + C PC N
Sbjct: 540 QNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPIN 599
Query: 621 CTQGCNGPTSHDCIYYPWTGHSTLPQHAR----TPLIAAGVIGGLFILVIVGLTFAVYVR 676
CT C C P R T +I+A V G+ ++V++G+ F + ++
Sbjct: 600 CTHSCVDLDDKGC-----------PAEQRASPLTSIISAVV--GILLVVVLGVVFGILIK 646
Query: 677 RKSIK-KKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYK 734
R+ K +K +RR L ETELVEPLTPSG PNQAQ+RILKETEL++VKVLGSGAFGTVYK
Sbjct: 647 RRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYK 706
Query: 735 GIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL 794
GIW+P+GE VKIPVAIK+L E T PKAN E +DEA +MA + P++ RLLG+CL+ T+QL
Sbjct: 707 GIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL 766
Query: 795 VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSP 854
VTQLMP+GCLL++V E++ +GSQ LLNWC+QIAKGM YLE+ RLVHRDLAARNVLVKSP
Sbjct: 767 VTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSP 826
Query: 855 NHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELM 914
NHVKITDFGLARLL+ DE EY+ADGGK+PIKWMALE I R+FTHQSDVWSYGVT+WELM
Sbjct: 827 NHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELM 886
Query: 915 TFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEF 974
TFG KPYDGIP REIPDLLEKGERLPQPPICTIDVYM+MVKCWMID++ RP+F+EL +EF
Sbjct: 887 TFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF 946
Query: 975 SRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQ-AFNIPPP 1033
SRMARDPQR++VIQ +D + SP DS F+++LL+++D+ D++DAEEYLVPQ F P P
Sbjct: 947 SRMARDPQRFVVIQNED-LGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDP 1005
Query: 1034 IYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQG---VSVPYRAPTSTIPE 1090
P +G +R + G +++ P
Sbjct: 1006 -----------------------APGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPR 1042
Query: 1091 APVA--QGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEE 1148
+P+A +GA +++FD G + + + S QRYS DPTV P + +
Sbjct: 1043 SPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSET-------D 1095
Query: 1149 GYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQA-------LDNPEYHN-ASNGPPK--- 1197
GY+ P+ P+ EY+N + P + G L A L+ P+ + NG K
Sbjct: 1096 GYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVF 1155
Query: 1198 AEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRS------ 1251
A V P YL + P AFDN YW+ P R
Sbjct: 1156 AFGGAVENPEYLTPQGGAAPQPH--------PPPAFSPAFDNLYYWDQDPPERGAPPSTF 1207
Query: 1252 ----TLQHPDYL 1259
T ++P+YL
Sbjct: 1208 KGTPTAENPEYL 1219
>gi|41327736 epidermal growth factor receptor isoform d precursor
[Homo sapiens]
Length = 705
Score = 631 bits (1627), Expect = e-180
Identities = 293/605 (48%), Positives = 392/605 (64%), Gaps = 7/605 (1%)
Query: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
Query: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
Query: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
Query: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
Query: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
Query: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
Query: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
+DP++L++ +TV+EITGFL IQ+WP N TD F NL I GR G L +
Sbjct: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443
Query: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
ITSL +SLKEIS G++ I+ N NLCY +TINW LF T Q+ I NR +C A G
Sbjct: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503
Query: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
VC+ LCS +GCWGP P C+SCR SRGR C++ CNL +GE REF S C++C P+C
Sbjct: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563
Query: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA-NSFIFKYADPDRECHPCHP 619
+TC G GPDNC +C+H+ DGP+CV+ CP G+ G N+ ++KYAD CH CHP
Sbjct: 564 PQAMN-ITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622
Query: 620 NCTQG 624
NCT G
Sbjct: 623 NCTYG 627
Score = 68.6 bits (166), Expect = 4e-11
Identities = 74/320 (23%), Positives = 115/320 (35%), Gaps = 83/320 (25%)
Query: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
F NC + GNL + D L+ +T++E+ G++ I N +
Sbjct: 55 FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99
Query: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
NL I G + Y LS + G+ L ++L+EI G + ++N LC
Sbjct: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159
Query: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
+I W + S+ + + +N C+ C + CWG G + C +
Sbjct: 160 ESIQWRDIVSS---DFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213
Query: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKD---- 585
IC + C+ G R ++ S C C QC C GP +C C F+D
Sbjct: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQCAA------GCTGPRESDCLVCRKFRDEATC 260
Query: 586 ---------------------------GPNCVEKCPDGLQ-----------GANSFIFKY 607
G CV+KCP GA+S+ +
Sbjct: 261 KDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEME- 319
Query: 608 ADPDRECHPCHPNCTQGCNG 627
D R+C C C + CNG
Sbjct: 320 EDGVRKCKKCEGPCRKVCNG 339
>gi|41327732 epidermal growth factor receptor isoform b precursor
[Homo sapiens]
Length = 628
Score = 631 bits (1627), Expect = e-180
Identities = 293/605 (48%), Positives = 392/605 (64%), Gaps = 7/605 (1%)
Query: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
Query: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
Query: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
Query: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
Query: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
Query: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
Query: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
+DP++L++ +TV+EITGFL IQ+WP N TD F NL I GR G L +
Sbjct: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443
Query: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
ITSL +SLKEIS G++ I+ N NLCY +TINW LF T Q+ I NR +C A G
Sbjct: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503
Query: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
VC+ LCS +GCWGP P C+SCR SRGR C++ CNL +GE REF S C++C P+C
Sbjct: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563
Query: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA-NSFIFKYADPDRECHPCHP 619
+TC G GPDNC +C+H+ DGP+CV+ CP G+ G N+ ++KYAD CH CHP
Sbjct: 564 PQAMN-ITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622
Query: 620 NCTQG 624
NCT G
Sbjct: 623 NCTYG 627
Score = 68.6 bits (166), Expect = 4e-11
Identities = 74/320 (23%), Positives = 115/320 (35%), Gaps = 83/320 (25%)
Query: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
F NC + GNL + D L+ +T++E+ G++ I N +
Sbjct: 55 FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99
Query: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
NL I G + Y LS + G+ L ++L+EI G + ++N LC
Sbjct: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159
Query: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
+I W + S+ + + +N C+ C + CWG G + C +
Sbjct: 160 ESIQWRDIVSS---DFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213
Query: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKD---- 585
IC + C+ G R ++ S C C QC C GP +C C F+D
Sbjct: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQCAA------GCTGPRESDCLVCRKFRDEATC 260
Query: 586 ---------------------------GPNCVEKCPDGLQ-----------GANSFIFKY 607
G CV+KCP GA+S+ +
Sbjct: 261 KDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEME- 319
Query: 608 ADPDRECHPCHPNCTQGCNG 627
D R+C C C + CNG
Sbjct: 320 EDGVRKCKKCEGPCRKVCNG 339
>gi|41327734 epidermal growth factor receptor isoform c precursor
[Homo sapiens]
Length = 405
Score = 390 bits (1003), Expect = e-108
Identities = 179/380 (47%), Positives = 250/380 (65%), Gaps = 5/380 (1%)
Query: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
Query: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
Query: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
Query: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
Query: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
Query: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
Query: 381 IEAIDPEKLNVFRTVREITG 400
+DP++L++ +TV+EITG
Sbjct: 384 TPPLDPQELDILKTVKEITG 403
Score = 68.9 bits (167), Expect = 3e-11
Identities = 59/245 (24%), Positives = 96/245 (39%), Gaps = 40/245 (16%)
Query: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
F NC + GNL + D L+ +T++E+ G++ I N +
Sbjct: 55 FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99
Query: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
NL I G + Y LS + G+ L ++L+EI G + ++N LC
Sbjct: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159
Query: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
+I W + ++ + + +N C+ C + CWG G + C +
Sbjct: 160 ESIQWRDI---VSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213
Query: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNC 589
IC + C+ G R ++ S C C QC C GP +C C F+D C
Sbjct: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQC------AAGCTGPRESDCLVCRKFRDEATC 260
Query: 590 VEKCP 594
+ CP
Sbjct: 261 KDTCP 265
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 226 bits (577), Expect = 8e-59
Identities = 132/366 (36%), Positives = 202/366 (55%), Gaps = 15/366 (4%)
Query: 652 LIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRR--FLETELVEPLTP-----SGTA 704
+I +G + +LV+ G+ F ++ RRK+ + +++ F ++E ++PL +
Sbjct: 537 VIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYED 596
Query: 705 PNQAQLRILKETE---LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKA 761
PNQA L+ E + R KV+G+G FG VYKG+ ++PVAIK L K
Sbjct: 597 PNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQ 656
Query: 762 NVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLL 820
V+F+ EA IM H +++RL GV + ++T+ M +G L +++ E L
Sbjct: 657 RVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQL 716
Query: 821 LNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD-EKEYNADG 879
+ IA GM YL VHRDLAARN+LV S K++DFGL+R+LE D E Y G
Sbjct: 717 VGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSG 776
Query: 880 GKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERL 939
GK+PI+W A E I YRKFT SDVWS+G+ +WE+MT+G +PY + E+ + G RL
Sbjct: 777 GKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRL 836
Query: 940 PQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDD---RMKLP 996
P P C +Y +M++CW + RPKF ++ + ++ R P + D ++LP
Sbjct: 837 PTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLP 896
Query: 997 SPNDSK 1002
S + S+
Sbjct: 897 STSGSE 902
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 220 bits (561), Expect = 6e-57
Identities = 114/295 (38%), Positives = 173/295 (58%), Gaps = 7/295 (2%)
Query: 703 TAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN 762
T P+ I +E ++ + +G G FG V++GI++ E + VAIK T
Sbjct: 430 TMPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVR 487
Query: 763 VEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
+F+ EAL M DHPH+V+L+GV + ++ +L G L ++ K ++ L+
Sbjct: 488 EKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL 547
Query: 823 WCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKM 882
+ Q++ + YLE +R VHRD+AARNVLV S + VK+ DFGL+R +E D Y A GK+
Sbjct: 548 YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKL 606
Query: 883 PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 942
PIKWMA E I++R+FT SDVW +GV +WE++ G KP+ G+ ++ +E GERLP P
Sbjct: 607 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 666
Query: 943 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPS 997
P C +Y +M KCW D RP+F EL A+ S + + + Q ++RM++ S
Sbjct: 667 PNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK----AQQEERMRMES 717
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 220 bits (561), Expect = 6e-57
Identities = 114/295 (38%), Positives = 173/295 (58%), Gaps = 7/295 (2%)
Query: 703 TAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN 762
T P+ I +E ++ + +G G FG V++GI++ E + VAIK T
Sbjct: 408 TMPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVR 465
Query: 763 VEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
+F+ EAL M DHPH+V+L+GV + ++ +L G L ++ K ++ L+
Sbjct: 466 EKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL 525
Query: 823 WCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKM 882
+ Q++ + YLE +R VHRD+AARNVLV S + VK+ DFGL+R +E D Y A GK+
Sbjct: 526 YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKL 584
Query: 883 PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 942
PIKWMA E I++R+FT SDVW +GV +WE++ G KP+ G+ ++ +E GERLP P
Sbjct: 585 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 644
Query: 943 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPS 997
P C +Y +M KCW D RP+F EL A+ S + + + Q ++RM++ S
Sbjct: 645 PNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK----AQQEERMRMES 695
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 214 bits (546), Expect = 3e-55
Identities = 125/376 (33%), Positives = 203/376 (53%), Gaps = 40/376 (10%)
Query: 722 KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
++LG G FG VY+G++ +GE KI VA+K + +FM EA+IM ++DHPH+
Sbjct: 429 RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
V+L+G+ ++ +L P+G L Y+ +K+++ L+ + +QI K M YLE V
Sbjct: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
HRD+A RN+LV SP VK+ DFGL+R +E DE Y A ++PIKWM+ E I++R+FT
Sbjct: 547 HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605
Query: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
SDVW + V +WE+++FG +P+ + +++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
Query: 961 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
RP+F EL S + + +++ E++
Sbjct: 666 PSDRPRFTELVCSLSDV-----------------------YQMEKDIAMEQERNARYRTP 702
Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGN-QFVYRDGGFAAEQGVSV 1079
+ L P AF PPP S + PPP ++ QF +G A+ ++
Sbjct: 703 KILEPTAFQEPPP----------KPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTS 752
Query: 1080 P--YRAPTSTIPEAPV 1093
P Y +P +++ P+
Sbjct: 753 PMEYPSPVNSLHTPPL 768
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 214 bits (546), Expect = 3e-55
Identities = 125/376 (33%), Positives = 203/376 (53%), Gaps = 40/376 (10%)
Query: 722 KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
++LG G FG VY+G++ +GE KI VA+K + +FM EA+IM ++DHPH+
Sbjct: 429 RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
V+L+G+ ++ +L P+G L Y+ +K+++ L+ + +QI K M YLE V
Sbjct: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
HRD+A RN+LV SP VK+ DFGL+R +E DE Y A ++PIKWM+ E I++R+FT
Sbjct: 547 HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605
Query: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
SDVW + V +WE+++FG +P+ + +++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
Query: 961 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
RP+F EL S + + +++ E++
Sbjct: 666 PSDRPRFTELVCSLSDV-----------------------YQMEKDIAMEQERNARYRTP 702
Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGN-QFVYRDGGFAAEQGVSV 1079
+ L P AF PPP S + PPP ++ QF +G A+ ++
Sbjct: 703 KILEPTAFQEPPP----------KPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTS 752
Query: 1080 P--YRAPTSTIPEAPV 1093
P Y +P +++ P+
Sbjct: 753 PMEYPSPVNSLHTPPL 768
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 214 bits (546), Expect = 3e-55
Identities = 125/376 (33%), Positives = 203/376 (53%), Gaps = 40/376 (10%)
Query: 722 KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
++LG G FG VY+G++ +GE KI VA+K + +FM EA+IM ++DHPH+
Sbjct: 429 RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
V+L+G+ ++ +L P+G L Y+ +K+++ L+ + +QI K M YLE V
Sbjct: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
HRD+A RN+LV SP VK+ DFGL+R +E DE Y A ++PIKWM+ E I++R+FT
Sbjct: 547 HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605
Query: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
SDVW + V +WE+++FG +P+ + +++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
Query: 961 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
RP+F EL S + + +++ E++
Sbjct: 666 PSDRPRFTELVCSLSDV-----------------------YQMEKDIAMEQERNARYRTP 702
Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGN-QFVYRDGGFAAEQGVSV 1079
+ L P AF PPP S + PPP ++ QF +G A+ ++
Sbjct: 703 KILEPTAFQEPPP----------KPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTS 752
Query: 1080 P--YRAPTSTIPEAPV 1093
P Y +P +++ P+
Sbjct: 753 PMEYPSPVNSLHTPPL 768
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 213 bits (543), Expect = 7e-55
Identities = 105/255 (41%), Positives = 163/255 (63%), Gaps = 4/255 (1%)
Query: 722 KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
++LG G FG VY+G++ +GE KI VA+K + +FM EA+IM ++DHPH+
Sbjct: 429 RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
V+L+G+ ++ +L P+G L Y+ +K+++ L+ + +QI K M YLE V
Sbjct: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
HRD+A RN+LV SP VK+ DFGL+R +E DE Y A ++PIKWM+ E I++R+FT
Sbjct: 547 HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605
Query: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
SDVW + V +WE+++FG +P+ + +++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
Query: 961 ADSRPKFKELAAEFS 975
RP+F EL S
Sbjct: 666 PSDRPRFTELVCSLS 680
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 213 bits (542), Expect = 1e-54
Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)
Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
++ T++ LG G +G VY G+W + + VA+K L E T EF+ EA +M
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 321
Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
+ HP+LV+LLGVC L P +VT+ MP+G LL+Y+ E +++ + + +LL QI+
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
M YLE++ +HRDLAARN LV + VK+ DFGL+RL+ GD +A G K PIKW A E
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 440
Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
+ Y F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
+M CW RP F E F M D
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 213 bits (542), Expect = 1e-54
Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)
Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
++ T++ LG G +G VY G+W + + VA+K L E T EF+ EA +M
Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 336
Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
+ HP+LV+LLGVC L P +VT+ MP+G LL+Y+ E +++ + + +LL QI+
Sbjct: 337 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 396
Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
M YLE++ +HRDLAARN LV + VK+ DFGL+RL+ GD +A G K PIKW A E
Sbjct: 397 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 455
Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
+ Y F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 515
Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
+M CW RP F E F M D
Sbjct: 516 ELMRACWKWSPADRPSFAETHQAFETMFHD 545
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 213 bits (542), Expect = 1e-54
Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)
Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
++ T++ LG G +G VY G+W + + VA+K L E T EF+ EA +M
Sbjct: 262 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 315
Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
+ HP+LV+LLGVC L P +VT+ MP+G LL+Y+ E +++ + + +LL QI+
Sbjct: 316 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 375
Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
M YLE++ +HRDLAARN LV + VK+ DFGL+RL+ GD +A G K PIKW A E
Sbjct: 376 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 434
Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
+ Y F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 435 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 494
Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
+M CW RP F E F M D
Sbjct: 495 ELMRACWKWSPADRPSFAETHQAFETMFHD 524
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 213 bits (542), Expect = 1e-54
Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)
Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
++ T++ LG G +G VY G+W + + VA+K L E T EF+ EA +M
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 321
Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
+ HP+LV+LLGVC L P +VT+ MP+G LL+Y+ E +++ + + +LL QI+
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
M YLE++ +HRDLAARN LV + VK+ DFGL+RL+ GD +A G K PIKW A E
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 440
Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
+ Y F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
+M CW RP F E F M D
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 213 bits (542), Expect = 1e-54
Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)
Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
++ T++ LG G +G VY G+W + + VA+K L E T EF+ EA +M
Sbjct: 247 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 300
Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
+ HP+LV+LLGVC L P +VT+ MP+G LL+Y+ E +++ + + +LL QI+
Sbjct: 301 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 360
Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
M YLE++ +HRDLAARN LV + VK+ DFGL+RL+ GD +A G K PIKW A E
Sbjct: 361 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 419
Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
+ Y F+ +SDVW++GV +WE+ T+G PY GI ++ DLLEKG R+ QP C VY
Sbjct: 420 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 479
Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
+M CW RP F E F M D
Sbjct: 480 ELMRACWKWSPADRPSFAETHQAFETMFHD 509
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 211 bits (537), Expect = 4e-54
Identities = 112/277 (40%), Positives = 171/277 (61%), Gaps = 3/277 (1%)
Query: 697 PLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIW-VPEGETVKIPVAIKILNE 755
P P+G P Q+ ++ E +L+ ++ LG G+FG V +G W P G+TV + V +
Sbjct: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 164
Query: 756 TTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNI 815
+ P+A +F+ E M S+DH +L+RL GV L+P +++VT+L P G LL+ + +H+ +
Sbjct: 165 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 224
Query: 816 GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL-EGDEKE 874
L + VQ+A+GM YLE +R +HRDLAARN+L+ + + VKI DFGL R L + D+
Sbjct: 225 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 284
Query: 875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 934
+ K+P W A E + R F+H SD W +GVT+WE+ T+G +P+ G+ +I ++
Sbjct: 285 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 344
Query: 935 K-GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 970
K GERLP+P C D+Y VMV+CW + RP F L
Sbjct: 345 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 211 bits (537), Expect = 4e-54
Identities = 112/277 (40%), Positives = 171/277 (61%), Gaps = 3/277 (1%)
Query: 697 PLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIW-VPEGETVKIPVAIKILNE 755
P P+G P Q+ ++ E +L+ ++ LG G+FG V +G W P G+TV + V +
Sbjct: 168 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 227
Query: 756 TTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNI 815
+ P+A +F+ E M S+DH +L+RL GV L+P +++VT+L P G LL+ + +H+ +
Sbjct: 228 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 287
Query: 816 GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL-EGDEKE 874
L + VQ+A+GM YLE +R +HRDLAARN+L+ + + VKI DFGL R L + D+
Sbjct: 288 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 347
Query: 875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 934
+ K+P W A E + R F+H SD W +GVT+WE+ T+G +P+ G+ +I ++
Sbjct: 348 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 407
Query: 935 K-GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 970
K GERLP+P C D+Y VMV+CW + RP F L
Sbjct: 408 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 444
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 211 bits (536), Expect = 5e-54
Identities = 127/349 (36%), Positives = 190/349 (54%), Gaps = 21/349 (6%)
Query: 651 PLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETE-----------LVEPLT 699
PLIA G+ +V + V R+++ K+ L+ ++P T
Sbjct: 540 PLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFT 599
Query: 700 PSGTAPNQAQLRILKETELKRVK---VLGSGAFGTVYKGIWVPEGETVKIPVAIKILNET 756
PN+A KE ++ VK V+G+G FG VYKG G+ +I VAIK L
Sbjct: 600 YED--PNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKR-EIYVAIKTLKAG 656
Query: 757 TGPKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHEHKDNI 815
K +F+ EA IM DHP+++RL GV S + ++T+ M +G L ++ ++
Sbjct: 657 YSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQF 716
Query: 816 GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE- 874
L+ IA GM YL E VHRDLAARN+LV S K++DFGL+R L+ D +
Sbjct: 717 TVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDP 776
Query: 875 -YNAD-GGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDL 932
Y + GGK+P++W A E I YRKFT SDVWSYG+ +WE+M+FG +PY + +++ +
Sbjct: 777 TYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINA 836
Query: 933 LEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDP 981
+E+ RLP P C ++ +M+ CW D +SRP+F E+ +M R+P
Sbjct: 837 IEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNP 885
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 209 bits (532), Expect = 1e-53
Identities = 113/284 (39%), Positives = 168/284 (59%), Gaps = 10/284 (3%)
Query: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTG 758
T G +PN + ++ T++ LG G +G VY+G+W + + VA+K L E T
Sbjct: 224 TVYGVSPNYDKWE-MERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKEDTM 278
Query: 759 PKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHE-HKDNIG 816
EF+ EA +M + HP+LV+LLGVC P ++T+ M +G LL+Y+ E ++ +
Sbjct: 279 EVE--EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 336
Query: 817 SQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYN 876
+ +LL QI+ M YLE++ +HRDLAARN LV + VK+ DFGL+RL+ GD +
Sbjct: 337 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH 396
Query: 877 ADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKG 936
A G K PIKW A E + Y KF+ +SDVW++GV +WE+ T+G PY GI ++ +LLEK
Sbjct: 397 A-GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD 455
Query: 937 ERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARD 980
R+ +P C VY +M CW + RP F E+ F M ++
Sbjct: 456 YRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE 499
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 209 bits (532), Expect = 1e-53
Identities = 113/284 (39%), Positives = 168/284 (59%), Gaps = 10/284 (3%)
Query: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTG 758
T G +PN + ++ T++ LG G +G VY+G+W + + VA+K L E T
Sbjct: 243 TVYGVSPNYDKWE-MERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKEDTM 297
Query: 759 PKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHE-HKDNIG 816
EF+ EA +M + HP+LV+LLGVC P ++T+ M +G LL+Y+ E ++ +
Sbjct: 298 EVE--EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 355
Query: 817 SQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYN 876
+ +LL QI+ M YLE++ +HRDLAARN LV + VK+ DFGL+RL+ GD +
Sbjct: 356 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH 415
Query: 877 ADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKG 936
A G K PIKW A E + Y KF+ +SDVW++GV +WE+ T+G PY GI ++ +LLEK
Sbjct: 416 A-GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD 474
Query: 937 ERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARD 980
R+ +P C VY +M CW + RP F E+ F M ++
Sbjct: 475 YRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE 518
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 206 bits (524), Expect = 1e-52
Identities = 124/346 (35%), Positives = 188/346 (54%), Gaps = 16/346 (4%)
Query: 648 ARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKK-------KRALRRFLETELVEPLTP 700
A + ++ V G + ++VI+ F + RR K ++ L + + T V+P T
Sbjct: 544 ANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRT-YVDPFTY 602
Query: 701 SGTAPNQAQLRILKETE---LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETT 757
PNQA KE + +K KV+G G FG V G G+ +I VAIK L
Sbjct: 603 ED--PNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKR-EICVAIKTLKAGY 659
Query: 758 GPKANVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIG 816
K +F+ EA IM DHP+++ L GV + ++T+ M +G L ++ ++
Sbjct: 660 TDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFT 719
Query: 817 SQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD-EKEY 875
L+ I GM YL + VHRDLAARN+LV S K++DFG++R+LE D E Y
Sbjct: 720 VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 779
Query: 876 NADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEK 935
GGK+PI+W A E I YRKFT SDVWSYG+ +WE+M++G +PY + +++ +E+
Sbjct: 780 TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEE 839
Query: 936 GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDP 981
G RLP P C I ++ +M+ CW + RPKF ++ ++ R+P
Sbjct: 840 GYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNP 885
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 206 bits (523), Expect = 2e-52
Identities = 113/289 (39%), Positives = 170/289 (58%), Gaps = 8/289 (2%)
Query: 705 PNQAQLRILKETELKRV---KVLGSGAFGTVYKG-IWVPEGETVKIPVAIKILNETTGPK 760
P QA KE + + KV+G+G FG V G + +P + +I VAIK L K
Sbjct: 605 PTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKK--EISVAIKTLKVGYTEK 662
Query: 761 ANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHEHKDNIGSQL 819
+F+ EA IM DHP+++RL GV S + +VT+ M +G L ++ +H
Sbjct: 663 QRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQ 722
Query: 820 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD-EKEYNAD 878
L+ IA GM YL + VHRDLAARN+L+ S K++DFGL+R+LE D E Y
Sbjct: 723 LVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 782
Query: 879 GGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGER 938
GGK+PI+W + E I YRKFT SDVWSYG+ +WE+M++G +PY + +++ +++G R
Sbjct: 783 GGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYR 842
Query: 939 LPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVI 987
LP P C +Y +M+ CW D ++RPKF+++ + ++ R+P +I
Sbjct: 843 LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKII 891
Score = 31.2 bits (69), Expect = 6.8
Identities = 19/65 (29%), Positives = 30/65 (46%), Gaps = 6/65 (9%)
Query: 507 CSSDGCWGPGPDQCLSCRRF--SRGRICIESCNLYDGEFREFENGSICVECDPQCEKMED 564
CS++G W +C SC RG +C ++C G ++ + C +C P ED
Sbjct: 244 CSTEGEWLVPIGKC-SCNAGYEERGFMC-QACR--PGFYKALDGNMKCAKCPPHSSTQED 299
Query: 565 GLLTC 569
G + C
Sbjct: 300 GSMNC 304
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 205 bits (521), Expect = 3e-52
Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%)
Query: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780
K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++
Sbjct: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409
Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V
Sbjct: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468
Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+
Sbjct: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
Query: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588
Query: 960 DADSRPKF 967
D ++RP F
Sbjct: 589 DVENRPGF 596
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 205 bits (521), Expect = 3e-52
Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%)
Query: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780
K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++
Sbjct: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432
Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V
Sbjct: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+
Sbjct: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
Query: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611
Query: 960 DADSRPKF 967
D ++RP F
Sbjct: 612 DVENRPGF 619
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,222,159
Number of Sequences: 37866
Number of extensions: 2917465
Number of successful extensions: 9315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 563
Number of HSP's successfully gapped in prelim test: 288
Number of HSP's that attempted gapping in prelim test: 6722
Number of HSP's gapped (non-prelim): 1444
length of query: 1308
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1194
effective length of database: 13,930,794
effective search space: 16633368036
effective search space used: 16633368036
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.