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Search of human proteins with 4826980
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826980 nuclear receptor subfamily 1, group H, member 4
[Homo sapiens]
(472 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 964 0.0
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 261 1e-69
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 261 1e-69
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 244 1e-64
gi|194328806 nuclear receptor subfamily 1, group H, member 3 iso... 201 1e-51
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 178 1e-44
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 178 1e-44
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 173 3e-43
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 173 3e-43
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 173 3e-43
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 171 2e-42
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 170 3e-42
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 170 3e-42
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 166 4e-41
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 166 4e-41
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 166 4e-41
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 166 4e-41
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 166 4e-41
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 166 4e-41
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 162 6e-40
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 160 2e-39
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 154 1e-37
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 150 3e-36
gi|116284373 peroxisome proliferative activated receptor gamma i... 145 6e-35
gi|20336229 peroxisome proliferative activated receptor gamma is... 145 6e-35
gi|116284368 peroxisome proliferative activated receptor gamma i... 145 6e-35
gi|116284370 peroxisome proliferative activated receptor gamma i... 145 6e-35
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 145 8e-35
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 140 2e-33
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 139 7e-33
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 964 bits (2493), Expect = 0.0
Identities = 472/472 (100%), Positives = 472/472 (100%)
Query: 1 MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQ 60
MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQ
Sbjct: 1 MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQ 60
Query: 61 ISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGR 120
ISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGR
Sbjct: 61 ISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGR 120
Query: 121 IKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQ 180
IKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQ
Sbjct: 121 IKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQ 180
Query: 181 ECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCR 240
ECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCR
Sbjct: 181 ECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCR 240
Query: 241 EKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVE 300
EKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVE
Sbjct: 241 EKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVE 300
Query: 301 FTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDE 360
FTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDE
Sbjct: 301 FTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDE 360
Query: 361 YITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCK 420
YITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCK
Sbjct: 361 YITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCK 420
Query: 421 IHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ 472
IHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
Sbjct: 421 IHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ 472
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 261 bits (666), Expect = 1e-69
Identities = 152/390 (38%), Positives = 214/390 (54%), Gaps = 17/390 (4%)
Query: 92 PAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFF 151
P L + E + + R A ++ G+ELC VCGD+ASG+HYN L+CEGCKGFF
Sbjct: 18 PTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFF 77
Query: 152 RRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKN 211
RRS+ K A Y C +GG+C MD YMRRKCQECRLRKC++ GM EC+L+E Q + K+L++
Sbjct: 78 RRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQ 137
Query: 212 VKQHADQTV---NEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQE 268
++ A T S + L Q++ EK Q F S + P
Sbjct: 138 EEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSF---SDRLRVTPWP 194
Query: 269 ITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAM 328
+ E + ++ F TE+A VQ +V+F K+LPGF L EDQIALLK SA+E M
Sbjct: 195 MAPDPHSRE-ARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVM 253
Query: 329 FLRSAEIFNKKLPSGHSDLL-------EERIRNSGISDEYITPMFSFYKSIGELKMTQEE 381
L ++ +N P S E +G+ E+I P+F F +++ EL++ E
Sbjct: 254 LLETSRRYN---PGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 310
Query: 382 YALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELR 441
+ALL AI I S DR ++D+ VE+LQ ++ L IH P + F +L +L LR
Sbjct: 311 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 370
Query: 442 TFNHHHAEMLMSWRVNDHKFTPLLCEIWDV 471
T + H+E + + R+ D K PLL EIWDV
Sbjct: 371 TLSSVHSEQVFALRLQDKKLPPLLSEIWDV 400
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 261 bits (666), Expect = 1e-69
Identities = 152/390 (38%), Positives = 214/390 (54%), Gaps = 17/390 (4%)
Query: 92 PAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFF 151
P L + E + + R A ++ G+ELC VCGD+ASG+HYN L+CEGCKGFF
Sbjct: 63 PTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFF 122
Query: 152 RRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKN 211
RRS+ K A Y C +GG+C MD YMRRKCQECRLRKC++ GM EC+L+E Q + K+L++
Sbjct: 123 RRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQ 182
Query: 212 VKQHADQTV---NEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQE 268
++ A T S + L Q++ EK Q F S + P
Sbjct: 183 EEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSF---SDRLRVTPWP 239
Query: 269 ITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAM 328
+ E + ++ F TE+A VQ +V+F K+LPGF L EDQIALLK SA+E M
Sbjct: 240 MAPDPHSRE-ARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVM 298
Query: 329 FLRSAEIFNKKLPSGHSDLL-------EERIRNSGISDEYITPMFSFYKSIGELKMTQEE 381
L ++ +N P S E +G+ E+I P+F F +++ EL++ E
Sbjct: 299 LLETSRRYN---PGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 355
Query: 382 YALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELR 441
+ALL AI I S DR ++D+ VE+LQ ++ L IH P + F +L +L LR
Sbjct: 356 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 415
Query: 442 TFNHHHAEMLMSWRVNDHKFTPLLCEIWDV 471
T + H+E + + R+ D K PLL EIWDV
Sbjct: 416 TLSSVHSEQVFALRLQDKKLPPLLSEIWDV 445
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 244 bits (623), Expect = 1e-64
Identities = 142/390 (36%), Positives = 215/390 (55%), Gaps = 28/390 (7%)
Query: 110 KKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAV--YKCKNGG 167
++ R A ++ G ELC VCGD+ASG+HYN L+CEGCKGFFRRS+ + Y C+ GG
Sbjct: 70 ERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGG 129
Query: 168 NCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHAD---------Q 218
C MD +MRRKCQ+CRLRKCKE GM +C+L+E Q + K++RK +Q + Q
Sbjct: 130 TCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQ 189
Query: 219 TVNEDSEGRDL----RQVTSTTKSCREKTELTPDQQTLLHFIMDSY---NKQRMPQE--I 269
+ + G + S E +LT Q+ ++ ++ + NK+ + +
Sbjct: 190 GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKV 249
Query: 270 TNKIL----KEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAV 325
T L + + ++ F TE+A VQ +V+F K++PGF L EDQIALLK S +
Sbjct: 250 TPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTI 309
Query: 326 EAMFLRSAEIFNKKLPS----GHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEE 381
E M L +A +N + ++ +G+ E+I P+F F +++ L + E
Sbjct: 310 EIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAE 369
Query: 382 YALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELR 441
YALL AI I S DR +++ VE LQ+P ++ L +I +P++ F +L +L LR
Sbjct: 370 YALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLR 429
Query: 442 TFNHHHAEMLMSWRVNDHKFTPLLCEIWDV 471
T + H+E + + R+ D K PLL EIWDV
Sbjct: 430 TLSSVHSEQVFALRLQDKKLPPLLSEIWDV 459
>gi|194328806 nuclear receptor subfamily 1, group H, member 3
isoform b [Homo sapiens]
Length = 387
Score = 201 bits (511), Expect = 1e-51
Identities = 130/383 (33%), Positives = 189/383 (49%), Gaps = 63/383 (16%)
Query: 92 PAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFF 151
P L + E + + R A ++ G+ELC VCGD+ASG+HYN L+CEGCKGFF
Sbjct: 63 PTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFF 122
Query: 152 RRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKN 211
RRS+ K A Y C +GG+C MD YMRRKCQECRLRKC++ GM EC+L+E Q RL+K
Sbjct: 123 RRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI---RLKKL 179
Query: 212 VKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSY---NKQRMPQE 268
+Q E + L S+ +L+P+Q ++ ++ + N++
Sbjct: 180 KRQE-----EEQAHATSLPPRASSPPQILP--QLSPEQLGMIEKLVAAQQQCNRRSFSDR 232
Query: 269 ITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAM 328
+ ++ E S N PG + I LK
Sbjct: 233 LRVTVMLLETSRRYN----------------------PG------SESITFLKD------ 258
Query: 329 FLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAI 388
F + E F K +G+ E+I P+F F +++ EL++ E+ALL AI
Sbjct: 259 FSYNREDFAK----------------AGLQVEFINPIFEFSRAMNELQLNDAEFALLIAI 302
Query: 389 VILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHA 448
I S DR ++D+ VE+LQ ++ L IH P + F +L +L LRT + H+
Sbjct: 303 SIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHS 362
Query: 449 EMLMSWRVNDHKFTPLLCEIWDV 471
E + + R+ D K PLL EIWDV
Sbjct: 363 EQVFALRLQDKKLPPLLSEIWDV 385
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 178 bits (451), Expect = 1e-44
Identities = 119/373 (31%), Positives = 186/373 (49%), Gaps = 38/373 (10%)
Query: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKN--AVYKCKNGGNCVMDMYMRRKCQE 181
DE CVVCGD+A+GYHY +TCEGCKGFFRR+I KN Y CK CV+D R +CQ
Sbjct: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241
CR +KC +GM + +L + + +K RK ++Q+ R+ R+ +S ++
Sbjct: 110 CRFKKCIAVGMAMDLVLDDSKRVAK--RKLIEQN-----------RERRRKEEMIRSLQQ 156
Query: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285
+ E TP++ L+H +++ N Q + K L ++ E F
Sbjct: 157 RPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFS 216
Query: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341
T++ T + +V+F KKLP F L EDQI LLKG +E M LR+A ++ +
Sbjct: 217 EFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTL 276
Query: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401
SG + E+++N G+ +F KS+ + E ALL A++++S DR +
Sbjct: 277 SGEMAVKREQLKNGGLG-VVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCV 335
Query: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVN--DH 459
+ +EK QE L + + P + LL ++T+LR HA + +V
Sbjct: 336 DKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTE 395
Query: 460 KFTPLLCEIWDVQ 472
F PL E+++ Q
Sbjct: 396 LFPPLFLEVFEDQ 408
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 178 bits (451), Expect = 1e-44
Identities = 122/380 (32%), Positives = 197/380 (51%), Gaps = 24/380 (6%)
Query: 108 VTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCK-NG 166
V KP + A + G ++C VCGD+A+GYH+N +TCEGCKGFFRR++ +NA +C
Sbjct: 23 VPGKPSVNADE-EVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRK 81
Query: 167 GNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRL---RKNVKQHADQTVNED 223
G C + RR+CQ CRLRKC E GM E ++++ + +R RK ++ Q +
Sbjct: 82 GACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQ 141
Query: 224 SEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQE--ITNKILKEEFSAE 281
+ R + + KT T T HF + Q ++ + N + +
Sbjct: 142 GLTEEQRMMIRELMDAQMKTFDT----TFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGK 197
Query: 282 ENFLIL---TEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNK 338
E F +L +M+T + ++ F K + F+ L EDQI+LLKG+A E LR +FN
Sbjct: 198 EIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNA 257
Query: 339 KLPSGHSDLLEERIRNS--GISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQ 396
+ + L + ++ G + PM F+ + +L++ +EEY L+ AI + SPDR
Sbjct: 258 ETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRP 317
Query: 397 YIKDREAVEKLQEPLLDVLQKLCKIHQPENPQH---FACLLGRLTELRTFNHHHAEMLMS 453
+ V++LQE L+ + ++P+ P H F ++ LTELR+ N H + L+
Sbjct: 318 GVLQHRVVDQLQEQFAITLKSYIECNRPQ-PAHRFLFLKIMAMLTELRSINAQHTQRLL- 375
Query: 454 WRVND-HKF-TPLLCEIWDV 471
R+ D H F TPL+ E++ +
Sbjct: 376 -RIQDIHPFATPLMQELFGI 394
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 173 bits (439), Expect = 3e-43
Identities = 120/371 (32%), Positives = 179/371 (48%), Gaps = 38/371 (10%)
Query: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKN--AVYKCKNGGNCVMDMYMRRKCQE 181
DELCVVCGD+A+GYHY +TCEGCKGFFRR+I KN Y CK G CV+D R +CQE
Sbjct: 104 DELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQE 163
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241
CR +KC +GM + +L + SKRL K E R+ R+ KS
Sbjct: 164 CRFKKCIYVGMATDLVLDD----SKRLAKR---------KLIEENREKRRREELQKSIGH 210
Query: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285
K E T ++ L+ + +++ N Q + K L E+ E F
Sbjct: 211 KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFS 270
Query: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341
T++ T + +V+F KKLP F L EDQI LLKG +E M LR+A ++ +
Sbjct: 271 HFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTL 330
Query: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401
+G + +++N G+ +F S+ + E ALL A++++S DR +
Sbjct: 331 NGEMAVTRGQLKNGGLG-VVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACV 389
Query: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVN--DH 459
E +EK Q+ L + + + LL ++T+LR HA + +V
Sbjct: 390 ERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTE 449
Query: 460 KFTPLLCEIWD 470
F PL E+++
Sbjct: 450 LFPPLFLEVFE 460
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 173 bits (439), Expect = 3e-43
Identities = 120/371 (32%), Positives = 179/371 (48%), Gaps = 38/371 (10%)
Query: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKN--AVYKCKNGGNCVMDMYMRRKCQE 181
DELCVVCGD+A+GYHY +TCEGCKGFFRR+I KN Y CK G CV+D R +CQE
Sbjct: 104 DELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQE 163
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241
CR +KC +GM + +L + SKRL K E R+ R+ KS
Sbjct: 164 CRFKKCIYVGMATDLVLDD----SKRLAKR---------KLIEENREKRRREELQKSIGH 210
Query: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285
K E T ++ L+ + +++ N Q + K L E+ E F
Sbjct: 211 KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFS 270
Query: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341
T++ T + +V+F KKLP F L EDQI LLKG +E M LR+A ++ +
Sbjct: 271 HFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTL 330
Query: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401
+G + +++N G+ +F S+ + E ALL A++++S DR +
Sbjct: 331 NGEMAVTRGQLKNGGLG-VVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACV 389
Query: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVN--DH 459
E +EK Q+ L + + + LL ++T+LR HA + +V
Sbjct: 390 ERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTE 449
Query: 460 KFTPLLCEIWD 470
F PL E+++
Sbjct: 450 LFPPLFLEVFE 460
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 173 bits (439), Expect = 3e-43
Identities = 120/371 (32%), Positives = 179/371 (48%), Gaps = 38/371 (10%)
Query: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKN--AVYKCKNGGNCVMDMYMRRKCQE 181
DELCVVCGD+A+GYHY +TCEGCKGFFRR+I KN Y CK G CV+D R +CQE
Sbjct: 104 DELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQE 163
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241
CR +KC +GM + +L + SKRL K E R+ R+ KS
Sbjct: 164 CRFKKCIYVGMATDLVLDD----SKRLAKR---------KLIEENREKRRREELQKSIGH 210
Query: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285
K E T ++ L+ + +++ N Q + K L E+ E F
Sbjct: 211 KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFS 270
Query: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341
T++ T + +V+F KKLP F L EDQI LLKG +E M LR+A ++ +
Sbjct: 271 HFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTL 330
Query: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401
+G + +++N G+ +F S+ + E ALL A++++S DR +
Sbjct: 331 NGEMAVTRGQLKNGGLG-VVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACV 389
Query: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVN--DH 459
E +EK Q+ L + + + LL ++T+LR HA + +V
Sbjct: 390 ERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTE 449
Query: 460 KFTPLLCEIWD 470
F PL E+++
Sbjct: 450 LFPPLFLEVFE 460
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 171 bits (432), Expect = 2e-42
Identities = 110/334 (32%), Positives = 175/334 (52%), Gaps = 25/334 (7%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRK 186
C VC D++SGYHY CEGCKGFFRRSI KN +Y C NCV++ R +CQ CRL+K
Sbjct: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQK 140
Query: 187 CKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELT 246
C E+GM E + + ++K+ ++ KQ ++ +E DL T K + E
Sbjct: 141 CFEVGMSKESVRND---RNKKKKETSKQECTESYEMTAELDDL-----TEKIRKAHQETF 192
Query: 247 PDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLP 306
P L + +S R+ ++ L ++FS E+AT + +VEF K+LP
Sbjct: 193 PSLCQLGKYTTNSSADHRVRLDLG---LWDKFS---------ELATKCIIKIVEFAKRLP 240
Query: 307 GFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP----SGHSDLLEERIRNSGISDEYI 362
GF L DQI LLK + ++ + LR + + S L ++ N+G
Sbjct: 241 GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLT 299
Query: 363 TPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIH 422
+F+F + L+M E LL+AI ++ DRQ +++ V+KLQEPLL+ L+ +
Sbjct: 300 DLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKR 359
Query: 423 QPENPQHFACLLGRLTELRTFNHHHAEMLMSWRV 456
+P P F +L ++T+LR+ + AE +++ ++
Sbjct: 360 RPSKPHMFPKILMKITDLRSISAKGAERVITLKM 393
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 170 bits (430), Expect = 3e-42
Identities = 121/400 (30%), Positives = 198/400 (49%), Gaps = 56/400 (14%)
Query: 126 LCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLR 185
+C VCGDRA+G+H+NA+TCEGCKGFFRRS+ + A++ C G+C + RR CQ CRL+
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
Query: 186 KCKEMGMLAECLLT--EIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKT 243
+C ++GM+ E +LT E+Q K + + K ++ A + + +++ + KT
Sbjct: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
Query: 244 ------------------------ELTPDQQTLLHFIMDSYNK----------QRMPQEI 269
P+ + F DS +
Sbjct: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
Query: 270 TNKILKEEFSAEENF-LILTEMA-TNHVQVLVEFT--------KKLPGFQTLDHEDQIAL 319
+N L EE S + + L L++++ H+ LV ++ K +PGF+ L EDQI L
Sbjct: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
Query: 320 LKGSAVEAMFLRSAEIF---NKKLPSGHSD--LLEERIRNSGISDEYITPMFSFYKSIGE 374
LK SA+E + LRS E F + G+ D + +G S E I P+ F + +
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
Query: 375 LKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQH--FAC 432
L + +EE+ LL AI I+SPDR ++D +E +Q+ L + LQ + P H +A
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
Query: 433 LLGRLTELRTFNHHHAEM--LMSWRVN-DHKFTPLLCEIW 469
++ +L +LR+ N H++ +S++ K TPL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 170 bits (430), Expect = 3e-42
Identities = 121/400 (30%), Positives = 198/400 (49%), Gaps = 56/400 (14%)
Query: 126 LCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLR 185
+C VCGDRA+G+H+NA+TCEGCKGFFRRS+ + A++ C G+C + RR CQ CRL+
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
Query: 186 KCKEMGMLAECLLT--EIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKT 243
+C ++GM+ E +LT E+Q K + + K ++ A + + +++ + KT
Sbjct: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
Query: 244 ------------------------ELTPDQQTLLHFIMDSYNK----------QRMPQEI 269
P+ + F DS +
Sbjct: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
Query: 270 TNKILKEEFSAEENF-LILTEMA-TNHVQVLVEFT--------KKLPGFQTLDHEDQIAL 319
+N L EE S + + L L++++ H+ LV ++ K +PGF+ L EDQI L
Sbjct: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
Query: 320 LKGSAVEAMFLRSAEIF---NKKLPSGHSD--LLEERIRNSGISDEYITPMFSFYKSIGE 374
LK SA+E + LRS E F + G+ D + +G S E I P+ F + +
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
Query: 375 LKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQH--FAC 432
L + +EE+ LL AI I+SPDR ++D +E +Q+ L + LQ + P H +A
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
Query: 433 LLGRLTELRTFNHHHAEM--LMSWRVN-DHKFTPLLCEIW 469
++ +L +LR+ N H++ +S++ K TPL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 166 bits (420), Expect = 4e-41
Identities = 105/340 (30%), Positives = 170/340 (50%), Gaps = 37/340 (10%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRK 186
C VC D++SGYHY CEGCKGFFRRSI KN VY C NC+++ R +CQ CRL+K
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147
Query: 187 CKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELT 246
C E+GM E + + K K + K C E LT
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPK--------------------------PECSESYTLT 181
Query: 247 PDQQTLLHFIMDSYNKQ-----RMPQEITNKILKEEFSAE-ENFLILTEMATNHVQVLVE 300
P+ L+ + ++ + ++ + TN ++ S + + + +E++T + VE
Sbjct: 182 PEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVE 241
Query: 301 FTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP----SGHSDLLEERIRNSG 356
F K+LPGF TL DQI LLK + ++ + LR + + S L ++ N+G
Sbjct: 242 FAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 301
Query: 357 ISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQ 416
+F+F + L+M E LL+AI ++ DRQ ++ + V+ LQEPLL+ L+
Sbjct: 302 FG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 360
Query: 417 KLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRV 456
+ +P P F +L ++T+LR+ + AE +++ ++
Sbjct: 361 VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 400
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 166 bits (420), Expect = 4e-41
Identities = 105/340 (30%), Positives = 170/340 (50%), Gaps = 37/340 (10%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRK 186
C VC D++SGYHY CEGCKGFFRRSI KN VY C NC+++ R +CQ CRL+K
Sbjct: 83 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142
Query: 187 CKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELT 246
C E+GM E + + K K + K C E LT
Sbjct: 143 CFEVGMSKESVRNDRNKKKKEVPK--------------------------PECSESYTLT 176
Query: 247 PDQQTLLHFIMDSYNKQ-----RMPQEITNKILKEEFSAE-ENFLILTEMATNHVQVLVE 300
P+ L+ + ++ + ++ + TN ++ S + + + +E++T + VE
Sbjct: 177 PEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVE 236
Query: 301 FTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP----SGHSDLLEERIRNSG 356
F K+LPGF TL DQI LLK + ++ + LR + + S L ++ N+G
Sbjct: 237 FAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 296
Query: 357 ISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQ 416
+F+F + L+M E LL+AI ++ DRQ ++ + V+ LQEPLL+ L+
Sbjct: 297 FG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 355
Query: 417 KLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRV 456
+ +P P F +L ++T+LR+ + AE +++ ++
Sbjct: 356 VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 395
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 166 bits (420), Expect = 4e-41
Identities = 105/340 (30%), Positives = 170/340 (50%), Gaps = 37/340 (10%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRK 186
C VC D++SGYHY CEGCKGFFRRSI KN VY C NC+++ R +CQ CRL+K
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147
Query: 187 CKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELT 246
C E+GM E + + K K + K C E LT
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPK--------------------------PECSESYTLT 181
Query: 247 PDQQTLLHFIMDSYNKQ-----RMPQEITNKILKEEFSAE-ENFLILTEMATNHVQVLVE 300
P+ L+ + ++ + ++ + TN ++ S + + + +E++T + VE
Sbjct: 182 PEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVE 241
Query: 301 FTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP----SGHSDLLEERIRNSG 356
F K+LPGF TL DQI LLK + ++ + LR + + S L ++ N+G
Sbjct: 242 FAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 301
Query: 357 ISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQ 416
+F+F + L+M E LL+AI ++ DRQ ++ + V+ LQEPLL+ L+
Sbjct: 302 FG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 360
Query: 417 KLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRV 456
+ +P P F +L ++T+LR+ + AE +++ ++
Sbjct: 361 VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 400
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 166 bits (420), Expect = 4e-41
Identities = 109/329 (33%), Positives = 167/329 (50%), Gaps = 37/329 (11%)
Query: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNA--VYKCKNGGNCVMDMYMRRKCQE 181
DE CVVCGD+A+GYHY +TCEGCKGFFRR+I KN Y CK CV+D R +CQ
Sbjct: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241
CR +KC +GM + +L + + +KR K ++Q+ R+ R+ +S ++
Sbjct: 110 CRFKKCIAVGMAMDLVLDDSKRVAKR--KLIEQN-----------RERRRKEEMIRSLQQ 156
Query: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285
+ E TP++ L+H +++ N Q + K L ++ E F
Sbjct: 157 RPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFS 216
Query: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341
T++ T + +V+F KKLP F L EDQI LLKG +E M LR+A ++ +
Sbjct: 217 EFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTL 276
Query: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401
SG + E+++N G+ +F KS+ + E ALL A++++S DR +
Sbjct: 277 SGEMAVKREQLKNGGLG-VVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCV 335
Query: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHF 430
+ +EK QE L + H+ N HF
Sbjct: 336 DKIEKSQEAYLLAFEHYVN-HRKHNIPHF 363
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 166 bits (420), Expect = 4e-41
Identities = 108/334 (32%), Positives = 168/334 (50%), Gaps = 25/334 (7%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRK 186
C VC D++SGYHY +CEGCKGFFRRSI KN VY C NC+++ R +CQ CRL+K
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138
Query: 187 CKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELT 246
C E+GM E + + R K+ + + DS + TK + E
Sbjct: 139 CFEVGMSKEAVRND--------RNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETF 190
Query: 247 PDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLP 306
P L + +S R+ ++ L ++FS E+AT + +VEF K+LP
Sbjct: 191 PSLCQLGKYTTNSSADHRVQLDLG---LWDKFS---------ELATKCIIKIVEFAKRLP 238
Query: 307 GFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP----SGHSDLLEERIRNSGISDEYI 362
GF L DQI LLK + ++ + LR + + S L ++ N+G
Sbjct: 239 GFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLT 297
Query: 363 TPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIH 422
+F+F + L+M E LL+AI ++ DR +++ E V+KLQEPLL+ L+ +
Sbjct: 298 DLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRR 357
Query: 423 QPENPQHFACLLGRLTELRTFNHHHAEMLMSWRV 456
+P P F +L ++T+LR + AE ++ ++
Sbjct: 358 RPSQPYMFPRMLMKITDLRGISTKGAERAITLKM 391
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 166 bits (420), Expect = 4e-41
Identities = 108/334 (32%), Positives = 168/334 (50%), Gaps = 25/334 (7%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRK 186
C VC D++SGYHY +CEGCKGFFRRSI KN VY C NC+++ R +CQ CRL+K
Sbjct: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 149
Query: 187 CKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELT 246
C E+GM E + + R K+ + + DS + TK + E
Sbjct: 150 CFEVGMSKEAVRND--------RNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETF 201
Query: 247 PDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLP 306
P L + +S R+ ++ L ++FS E+AT + +VEF K+LP
Sbjct: 202 PSLCQLGKYTTNSSADHRVQLDLG---LWDKFS---------ELATKCIIKIVEFAKRLP 249
Query: 307 GFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP----SGHSDLLEERIRNSGISDEYI 362
GF L DQI LLK + ++ + LR + + S L ++ N+G
Sbjct: 250 GFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLT 308
Query: 363 TPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIH 422
+F+F + L+M E LL+AI ++ DR +++ E V+KLQEPLL+ L+ +
Sbjct: 309 DLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRR 368
Query: 423 QPENPQHFACLLGRLTELRTFNHHHAEMLMSWRV 456
+P P F +L ++T+LR + AE ++ ++
Sbjct: 369 RPSQPYMFPRMLMKITDLRGISTKGAERAITLKM 402
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 162 bits (410), Expect = 6e-40
Identities = 110/331 (33%), Positives = 174/331 (52%), Gaps = 23/331 (6%)
Query: 124 DEL--CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQE 181
DEL CVVCGD+A+GYH+NALTCEGCKGFFRR+++K+ C G+C + RR C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPA 65
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQT---VNEDSEGRDLRQVTSTTKS 238
CRL+KC + GM + +L+ + + R K ++ A QT ++++ E + + T+
Sbjct: 66 CRLQKCLDAGMRKDMILS-AEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRH 124
Query: 239 CREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVL 298
E + H + + Q +P L F+ F++L +
Sbjct: 125 MGTMFEQFVQFRPPAHLFI---HHQPLPTLAPVLPLVTHFADINTFMVLQ---------V 172
Query: 299 VEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNS--- 355
++FTK LP F++L EDQI+LLKG+AVE + F + + L I +
Sbjct: 173 IKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARV 232
Query: 356 GISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVL 415
G E++ +F F+ ++ +L++ + EY LL A+ + SPDR + R+ +++LQE + L
Sbjct: 233 GFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTL 292
Query: 416 QKLCKIHQ--PENPQHFACLLGRLTELRTFN 444
Q K Q P + +A LLG L ELR+ N
Sbjct: 293 QSYIKGQQRRPRDRFLYAKLLGLLAELRSIN 323
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 160 bits (406), Expect = 2e-39
Identities = 110/335 (32%), Positives = 174/335 (51%), Gaps = 27/335 (8%)
Query: 124 DEL--CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQE 181
DEL CVVCGD+A+GYH+NALTCEGCKGFFRR+++K+ C G+C + RR C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPA 65
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQT---VNEDSEGRDLRQVTSTTKS 238
CRL+KC + GM + +L+ + + R K ++ A QT ++++ E + + T+
Sbjct: 66 CRLQKCLDAGMRKDMILS-AEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRH 124
Query: 239 CREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVL 298
E + H + + Q +P L F+ F++L +
Sbjct: 125 MGTMFEQFVQFRPPAHLFI---HHQPLPTLAPVLPLVTHFADINTFMVLQ---------V 172
Query: 299 VEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNS--- 355
++FTK LP F++L EDQI+LLKG+AVE + F + + L I +
Sbjct: 173 IKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARV 232
Query: 356 ----GISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPL 411
G E++ +F F+ ++ +L++ + EY LL A+ + SPDR + R+ +++LQE +
Sbjct: 233 SPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEM 292
Query: 412 LDVLQKLCKIHQ--PENPQHFACLLGRLTELRTFN 444
LQ K Q P + +A LLG L ELR+ N
Sbjct: 293 ALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSIN 327
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 154 bits (390), Expect = 1e-37
Identities = 110/340 (32%), Positives = 174/340 (51%), Gaps = 32/340 (9%)
Query: 124 DEL--CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQE 181
DEL CVVCGD+A+GYH+NALTCEGCKGFFRR+++K+ C G+C + RR C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPA 65
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQT---VNEDSEGRDLRQVTSTTKS 238
CRL+KC + GM + +L+ + + R K ++ A QT ++++ E + + T+
Sbjct: 66 CRLQKCLDAGMRKDMILS-AEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRH 124
Query: 239 CREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVL 298
E + H + + Q +P L F+ F++L +
Sbjct: 125 MGTMFEQFVQFRPPAHLFI---HHQPLPTLAPVLPLVTHFADINTFMVLQ---------V 172
Query: 299 VEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNS--- 355
++FTK LP F++L EDQI+LLKG+AVE + F + + L I +
Sbjct: 173 IKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARV 232
Query: 356 ----GISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSP-----DRQYIKDREAVEK 406
G E++ +F F+ ++ +L++ + EY LL A+ + SP DR + R+ +++
Sbjct: 233 SPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQ 292
Query: 407 LQEPLLDVLQKLCKIHQ--PENPQHFACLLGRLTELRTFN 444
LQE + LQ K Q P + +A LLG L ELR+ N
Sbjct: 293 LQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSIN 332
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 150 bits (378), Expect = 3e-36
Identities = 100/312 (32%), Positives = 161/312 (51%), Gaps = 25/312 (8%)
Query: 124 DEL--CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQE 181
DEL CVVCGD+A+GYH+NALTCEGCKGFFRR+++K+ C G+C + RR C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPA 65
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQT---VNEDSEGRDLRQVTSTTKS 238
CRL+KC + GM + +L+ + + R K ++ A QT ++++ E + + T+
Sbjct: 66 CRLQKCLDAGMRKDMILS-AEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRH 124
Query: 239 CREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVL 298
E + H + + Q +P L F+ F++L +
Sbjct: 125 MGTMFEQFVQFRPPAHLFI---HHQPLPTLAPVLPLVTHFADINTFMVLQ---------V 172
Query: 299 VEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNS--- 355
++FTK LP F++L EDQI+LLKG+AVE + F + + L I +
Sbjct: 173 IKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARV 232
Query: 356 ----GISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPL 411
G E++ +F F+ ++ +L++ + EY LL A+ + SPDR + R+ +++LQE +
Sbjct: 233 SPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEM 292
Query: 412 LDVLQKLCKIHQ 423
LQ K Q
Sbjct: 293 ALTLQSYIKGQQ 304
>gi|116284373 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 145 bits (367), Expect = 6e-35
Identities = 107/365 (29%), Positives = 171/365 (46%), Gaps = 24/365 (6%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVY-KCKNGGNCVMDMYMRRKCQECRLR 185
C VCGD+ASG+HY CEGCKGFFRR+I +Y +C NC + R KCQ CR +
Sbjct: 111 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL--NCRIHKKSRNKCQYCRFQ 168
Query: 186 KCKEMGMLAECLL--TEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQ----------VT 233
KC +GM + Q + ++L + DQ E ++ R L +
Sbjct: 169 KCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPL 228
Query: 234 STTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEM--- 290
+ K+ T T D+ + + M+S + + +E S E I
Sbjct: 229 TKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFR 288
Query: 291 ATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKK---LPSGHSDL 347
+ VQ + E+ K +PGF LD DQ+ LLK E ++ A + NK + G +
Sbjct: 289 SVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFM 348
Query: 348 LEERIRNSGIS-DEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK 406
E +++ +++ P F F L++ + A+ A++ILS DR + + + +E
Sbjct: 349 TREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIED 408
Query: 407 LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEML--MSWRVNDHKFTPL 464
+Q+ LL L+ K++ PE+ Q FA LL ++T+LR H ++L + D PL
Sbjct: 409 IQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPL 468
Query: 465 LCEIW 469
L EI+
Sbjct: 469 LQEIY 473
>gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
Length = 505
Score = 145 bits (367), Expect = 6e-35
Identities = 107/365 (29%), Positives = 171/365 (46%), Gaps = 24/365 (6%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVY-KCKNGGNCVMDMYMRRKCQECRLR 185
C VCGD+ASG+HY CEGCKGFFRR+I +Y +C NC + R KCQ CR +
Sbjct: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL--NCRIHKKSRNKCQYCRFQ 196
Query: 186 KCKEMGMLAECLL--TEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQ----------VT 233
KC +GM + Q + ++L + DQ E ++ R L +
Sbjct: 197 KCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPL 256
Query: 234 STTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEM--- 290
+ K+ T T D+ + + M+S + + +E S E I
Sbjct: 257 TKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFR 316
Query: 291 ATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKK---LPSGHSDL 347
+ VQ + E+ K +PGF LD DQ+ LLK E ++ A + NK + G +
Sbjct: 317 SVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFM 376
Query: 348 LEERIRNSGIS-DEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK 406
E +++ +++ P F F L++ + A+ A++ILS DR + + + +E
Sbjct: 377 TREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIED 436
Query: 407 LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEML--MSWRVNDHKFTPL 464
+Q+ LL L+ K++ PE+ Q FA LL ++T+LR H ++L + D PL
Sbjct: 437 IQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPL 496
Query: 465 LCEIW 469
L EI+
Sbjct: 497 LQEIY 501
>gi|116284368 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 145 bits (367), Expect = 6e-35
Identities = 107/365 (29%), Positives = 171/365 (46%), Gaps = 24/365 (6%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVY-KCKNGGNCVMDMYMRRKCQECRLR 185
C VCGD+ASG+HY CEGCKGFFRR+I +Y +C NC + R KCQ CR +
Sbjct: 111 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL--NCRIHKKSRNKCQYCRFQ 168
Query: 186 KCKEMGMLAECLL--TEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQ----------VT 233
KC +GM + Q + ++L + DQ E ++ R L +
Sbjct: 169 KCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPL 228
Query: 234 STTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEM--- 290
+ K+ T T D+ + + M+S + + +E S E I
Sbjct: 229 TKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFR 288
Query: 291 ATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKK---LPSGHSDL 347
+ VQ + E+ K +PGF LD DQ+ LLK E ++ A + NK + G +
Sbjct: 289 SVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFM 348
Query: 348 LEERIRNSGIS-DEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK 406
E +++ +++ P F F L++ + A+ A++ILS DR + + + +E
Sbjct: 349 TREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIED 408
Query: 407 LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEML--MSWRVNDHKFTPL 464
+Q+ LL L+ K++ PE+ Q FA LL ++T+LR H ++L + D PL
Sbjct: 409 IQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPL 468
Query: 465 LCEIW 469
L EI+
Sbjct: 469 LQEIY 473
>gi|116284370 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 145 bits (367), Expect = 6e-35
Identities = 107/365 (29%), Positives = 171/365 (46%), Gaps = 24/365 (6%)
Query: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVY-KCKNGGNCVMDMYMRRKCQECRLR 185
C VCGD+ASG+HY CEGCKGFFRR+I +Y +C NC + R KCQ CR +
Sbjct: 111 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL--NCRIHKKSRNKCQYCRFQ 168
Query: 186 KCKEMGMLAECLL--TEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQ----------VT 233
KC +GM + Q + ++L + DQ E ++ R L +
Sbjct: 169 KCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPL 228
Query: 234 STTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEM--- 290
+ K+ T T D+ + + M+S + + +E S E I
Sbjct: 229 TKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFR 288
Query: 291 ATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKK---LPSGHSDL 347
+ VQ + E+ K +PGF LD DQ+ LLK E ++ A + NK + G +
Sbjct: 289 SVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFM 348
Query: 348 LEERIRNSGIS-DEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK 406
E +++ +++ P F F L++ + A+ A++ILS DR + + + +E
Sbjct: 349 TREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIED 408
Query: 407 LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEML--MSWRVNDHKFTPL 464
+Q+ LL L+ K++ PE+ Q FA LL ++T+LR H ++L + D PL
Sbjct: 409 IQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPL 468
Query: 465 LCEIW 469
L EI+
Sbjct: 469 LQEIY 473
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 145 bits (366), Expect = 8e-35
Identities = 100/313 (31%), Positives = 161/313 (51%), Gaps = 26/313 (8%)
Query: 124 DEL--CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQE 181
DEL CVVCGD+A+GYH+NALTCEGCKGFFRR+++K+ C G+C + RR C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPA 65
Query: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQT---VNEDSEGRDLRQVTSTTKS 238
CRL+KC + GM + +L+ + + R K ++ A QT ++++ E + + T+
Sbjct: 66 CRLQKCLDAGMRKDMILS-AEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRH 124
Query: 239 CREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVL 298
E + H + + Q +P L F+ F++L +
Sbjct: 125 MGTMFEQFVQFRPPAHLFI---HHQPLPTLAPVLPLVTHFADINTFMVLQ---------V 172
Query: 299 VEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNS--- 355
++FTK LP F++L EDQI+LLKG+AVE + F + + L I +
Sbjct: 173 IKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARV 232
Query: 356 GISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSP-----DRQYIKDREAVEKLQEP 410
G E++ +F F+ ++ +L++ + EY LL A+ + SP DR + R+ +++LQE
Sbjct: 233 GFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEE 292
Query: 411 LLDVLQKLCKIHQ 423
+ LQ K Q
Sbjct: 293 MALTLQSYIKGQQ 305
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 140 bits (354), Expect = 2e-33
Identities = 93/335 (27%), Positives = 153/335 (45%), Gaps = 34/335 (10%)
Query: 126 LCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLR 185
+C +CGDR+SG HY +CEGCKGFF+R+I K+ +Y C++ +C++D R +CQ CR +
Sbjct: 138 ICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQ 197
Query: 186 KCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTEL 245
KC MGM E +Q + +R R+ + A + E + ++ + KTE
Sbjct: 198 KCLVMGMKREA----VQEERQRSRERAESEA-ECATSGHEDMPVERILEAELAVEPKTE- 251
Query: 246 TPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKL 305
SY M E S + + A + LVE+ K++
Sbjct: 252 -------------SYGDMNM-----------ENSTNDPVTNICHAADKQLFTLVEWAKRI 287
Query: 306 PGFQTLDHEDQIALLKGSAVEAMFL----RSAEIFNKKLPSGHSDLLEERIRNSGISDEY 361
P F L EDQ+ LL+ E + RS + + L + + ++G+ +
Sbjct: 288 PHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIF 347
Query: 362 ITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKI 421
+ + +++M + E L AIV+ +PD + + + VE L+E + L+ K
Sbjct: 348 DRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQ 407
Query: 422 HQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRV 456
PE P FA LL RL LR+ E L +++
Sbjct: 408 KYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKL 442
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 139 bits (349), Expect = 7e-33
Identities = 93/335 (27%), Positives = 154/335 (45%), Gaps = 31/335 (9%)
Query: 126 LCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLR 185
+C +CGDR+SG HY +CEGCKGFF+R++ K+ Y C++ +C++D R +CQ CR +
Sbjct: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQ 193
Query: 186 KCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTEL 245
KC MGM E + E Q R V+ + + NED + ++ + KTE
Sbjct: 194 KCLAMGMKREAVQEERQRGKDRNENEVE--STSSANED---MPVERILEAELAVEPKTET 248
Query: 246 TPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKL 305
+ L N +TN + + A + LVE+ K++
Sbjct: 249 YVEANMGL-------NPSSPNDPVTN---------------ICQAADKQLFTLVEWAKRI 286
Query: 306 PGFQTLDHEDQIALLKGSAVEAMFL----RSAEIFNKKLPSGHSDLLEERIRNSGISDEY 361
P F L +DQ+ LL+ E + RS + + L + + ++G+ +
Sbjct: 287 PHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF 346
Query: 362 ITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKI 421
+ + +++M + E L AIV+ +PD + + + VE L+E + L+ CK
Sbjct: 347 DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKH 406
Query: 422 HQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRV 456
PE P FA LL RL LR+ E L +++
Sbjct: 407 KYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKL 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,180,600
Number of Sequences: 37866
Number of extensions: 828231
Number of successful extensions: 2726
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 118
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2364
Number of HSP's gapped (non-prelim): 218
length of query: 472
length of database: 18,247,518
effective HSP length: 106
effective length of query: 366
effective length of database: 14,233,722
effective search space: 5209542252
effective search space used: 5209542252
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.