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Search of human proteins with 48255931
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
(671 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 1327 0.0
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 1321 0.0
gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo... 207 3e-53
gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo ... 207 3e-53
gi|190014586 PC4 and SFRS1 interacting protein 1 isoform 1 [Homo... 203 5e-52
gi|7705320 hepatoma-derived growth factor, related protein 3 [Ho... 200 4e-51
gi|4758516 hepatoma-derived growth factor isoform a [Homo sapiens] 167 2e-41
gi|110681712 hepatoma derived growth factor-like 1 [Homo sapiens] 147 2e-35
gi|186928819 hepatoma-derived growth factor isoform b [Homo sapi... 129 1e-29
gi|186928821 hepatoma-derived growth factor isoform c [Homo sapi... 127 3e-29
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 95 2e-19
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 90 6e-18
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 85 2e-16
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 84 3e-16
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 84 4e-16
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 84 6e-16
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 83 9e-16
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 83 9e-16
gi|38788333 remodeling and spacing factor 1 [Homo sapiens] 82 1e-15
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 82 2e-15
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 81 4e-15
gi|217330641 IWS1 homolog [Homo sapiens] 80 8e-15
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 79 1e-14
gi|148746195 trichohyalin [Homo sapiens] 79 1e-14
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 78 2e-14
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 78 2e-14
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 77 7e-14
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 76 1e-13
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 75 2e-13
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 74 3e-13
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 1327 bits (3434), Expect = 0.0
Identities = 671/671 (100%), Positives = 671/671 (100%)
Query: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP
Sbjct: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
Query: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD
Sbjct: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
Query: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA
Sbjct: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
Query: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS
Sbjct: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
Query: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSS 300
DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSS
Sbjct: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSS 300
Query: 301 SSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRG 360
SSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRG
Sbjct: 301 SSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRG 360
Query: 361 EAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSS 420
EAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSS
Sbjct: 361 EAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSS 420
Query: 421 TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS 480
TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS
Sbjct: 421 TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS 480
Query: 481 EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA 540
EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA
Sbjct: 481 EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA 540
Query: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSA 600
EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSA
Sbjct: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSA 600
Query: 601 PVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERA 660
PVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERA
Sbjct: 601 PVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERA 660
Query: 661 RGDSEALDEES 671
RGDSEALDEES
Sbjct: 661 RGDSEALDEES 671
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 1321 bits (3418), Expect = 0.0
Identities = 670/671 (99%), Positives = 670/671 (99%), Gaps = 1/671 (0%)
Query: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP
Sbjct: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
Query: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD
Sbjct: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
Query: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA
Sbjct: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
Query: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS
Sbjct: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
Query: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSS 300
DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSS
Sbjct: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSS 300
Query: 301 SSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRG 360
SSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRG
Sbjct: 301 SSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRG 360
Query: 361 EAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSS 420
EAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSS
Sbjct: 361 EAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSS 420
Query: 421 TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS 480
TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS
Sbjct: 421 TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS 480
Query: 481 EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA 540
EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA
Sbjct: 481 EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA 540
Query: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSA 600
EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSA
Sbjct: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSA 600
Query: 601 PVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERA 660
PVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHD VREGPDLDRPGSDRQERERA
Sbjct: 601 PVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHD-VREGPDLDRPGSDRQERERA 659
Query: 661 RGDSEALDEES 671
RGDSEALDEES
Sbjct: 660 RGDSEALDEES 670
>gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 207 bits (527), Expect = 3e-53
Identities = 181/633 (28%), Positives = 280/633 (44%), Gaps = 126/633 (19%)
Query: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
M FKPGDL+FAKMKGYPHWPAR+D++ DGAVKPP NK PIFFFGTHETAFLGPKD+FP
Sbjct: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
Query: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
Y + K+KYGKPNKRKGFNEGLWEI NNP + SS + ++N + SD + ++
Sbjct: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKF------SSQQAATKQSNAS--SDVEVEE 112
Query: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
++ V + D+D ++ + N + + ++R RK ++ Q
Sbjct: 113 KETSV--------------SKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAE-KQV 157
Query: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
+ + ++S + K S + P AA P G K K P S+SD +
Sbjct: 158 ETEEAGVVTTATASVNLKVSPKRGRP---AATEVKIPKPRGRPKMVKQPCPSESDIITEE 214
Query: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE----- 295
D S KK G+K +KP +P ++ K E
Sbjct: 215 D-------------KSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKR 261
Query: 296 ----RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE 351
+ +S+SDS+ + D+ E KR+ R + RR + + EKE +
Sbjct: 262 KNLAKTGVTSTSDSEEEGDDQEGEKKRKG---GRNFQTAHRRNMLK-----GQHEKEAAD 313
Query: 352 RRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKK 411
R+R++ ++ E E+ E +P K+ K R +S DS + + E K
Sbjct: 314 RKRKQEEQMETEQ-------QNKDEGKKPEVKKVEKKR----ETSMDSRLQ-RIHAEIKN 361
Query: 412 SAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEK-KKEPS 470
S K + + ++ + V +++ +K +E + +K+ + K
Sbjct: 362 SLKIDNL----------DVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQV 411
Query: 471 VEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYK 530
+ EK L+++ K V D V +Q+L K+ +A ++
Sbjct: 412 IMEKSTMLYNKFKNMFLVGEGD--------------SVITQVLNKS---LAEQRQHEEAN 454
Query: 531 ANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKL--AGEELAGEEAPQE 588
KD +K GP NK +EKE+ K G + PQ
Sbjct: 455 KTKDQGKK-------------GP--------NKK-LEKEQTGSKTLNGGSDAQDGNQPQH 492
Query: 589 KAE-DKPSTDLSAPVNGEATSQKGESAEDKEHE 620
E ++ S D N EA+++K S+E++E E
Sbjct: 493 NGESNEDSKD-----NHEASTKKKPSSEERETE 520
Score = 174 bits (440), Expect = 3e-43
Identities = 152/517 (29%), Positives = 263/517 (50%), Gaps = 90/517 (17%)
Query: 160 PALKMSVSKRARK---ASSDLD----QASVSPSEEENSESSSESEKTSDQDFTPEKKAAV 212
P +K S + A K ASSD++ + SVS + ++ E +S + T D T K A
Sbjct: 88 PKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAA-- 145
Query: 213 RAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKK 272
RRG +K+KA +++ A +++++S + VS
Sbjct: 146 ---RRG-----RKRKAEKQVETEE-----------------AGVVTTATASVNLKVS--- 177
Query: 273 PPRGRKPA-EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARR 331
P RGR A E +PKPRGR PK + P S SD ++E D+++++ E ++
Sbjct: 178 PKRGRPAATEVKIPKPRGR-PKMVKQPCPSESDIITEE----------DKSKKKGQEEKQ 226
Query: 332 RREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGR 391
++Q ++ E +KEE + R+E + +E + V+ + +
Sbjct: 227 PKKQP---KKDEEGQKEEDKPRKE----------------PDKKEGKKEVESKRKNLAKT 267
Query: 392 GPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARK--PGQKEKRVRPEEKQQAKPVKVER 449
G S+SDSE E + ++E +K K ++ T R GQ EK +++Q + ++ E+
Sbjct: 268 GVTSTSDSEEEGD-DQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQ 326
Query: 450 TRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVT 509
K +KVEKK+E S++ +LQ++H+EIK +LK+D+ DV RC+ AL+EL +LQVT
Sbjct: 327 QNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVT 386
Query: 510 SQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAV--QKVNKAGME 567
Q QK+T+++ TLKKIRR+K ++ +MEK+ +Y + K+ L + ++V Q +NK+ E
Sbjct: 387 MQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAE 446
Query: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
+ + EE ++ G++ P +K E + + S +NG + +Q G ++ G +E+
Sbjct: 447 QRQHEEANKTKD-QGKKGPNKKLEKEQTG--SKTLNGGSDAQDG----NQPQHNGESNED 499
Query: 628 GPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDS 664
S+D H E +P S+ +E E + DS
Sbjct: 500 ------SKDNH----EASTKKKPSSEERETEISLKDS 526
>gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 207 bits (527), Expect = 3e-53
Identities = 181/633 (28%), Positives = 280/633 (44%), Gaps = 126/633 (19%)
Query: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
M FKPGDL+FAKMKGYPHWPAR+D++ DGAVKPP NK PIFFFGTHETAFLGPKD+FP
Sbjct: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
Query: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
Y + K+KYGKPNKRKGFNEGLWEI NNP + SS + ++N + SD + ++
Sbjct: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKF------SSQQAATKQSNAS--SDVEVEE 112
Query: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
++ V + D+D ++ + N + + ++R RK ++ Q
Sbjct: 113 KETSV--------------SKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAE-KQV 157
Query: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
+ + ++S + K S + P AA P G K K P S+SD +
Sbjct: 158 ETEEAGVVTTATASVNLKVSPKRGRP---AATEVKIPKPRGRPKMVKQPCPSESDIITEE 214
Query: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE----- 295
D S KK G+K +KP +P ++ K E
Sbjct: 215 D-------------KSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKR 261
Query: 296 ----RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE 351
+ +S+SDS+ + D+ E KR+ R + RR + + EKE +
Sbjct: 262 KNLAKTGVTSTSDSEEEGDDQEGEKKRKG---GRNFQTAHRRNMLK-----GQHEKEAAD 313
Query: 352 RRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKK 411
R+R++ ++ E E+ E +P K+ K R +S DS + + E K
Sbjct: 314 RKRKQEEQMETEQ-------QNKDEGKKPEVKKVEKKR----ETSMDSRLQ-RIHAEIKN 361
Query: 412 SAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEK-KKEPS 470
S K + + ++ + V +++ +K +E + +K+ + K
Sbjct: 362 SLKIDNL----------DVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQV 411
Query: 471 VEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYK 530
+ EK L+++ K V D V +Q+L K+ +A ++
Sbjct: 412 IMEKSTMLYNKFKNMFLVGEGD--------------SVITQVLNKS---LAEQRQHEEAN 454
Query: 531 ANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKL--AGEELAGEEAPQE 588
KD +K GP NK +EKE+ K G + PQ
Sbjct: 455 KTKDQGKK-------------GP--------NKK-LEKEQTGSKTLNGGSDAQDGNQPQH 492
Query: 589 KAE-DKPSTDLSAPVNGEATSQKGESAEDKEHE 620
E ++ S D N EA+++K S+E++E E
Sbjct: 493 NGESNEDSKD-----NHEASTKKKPSSEERETE 520
Score = 174 bits (440), Expect = 3e-43
Identities = 152/517 (29%), Positives = 263/517 (50%), Gaps = 90/517 (17%)
Query: 160 PALKMSVSKRARK---ASSDLD----QASVSPSEEENSESSSESEKTSDQDFTPEKKAAV 212
P +K S + A K ASSD++ + SVS + ++ E +S + T D T K A
Sbjct: 88 PKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAA-- 145
Query: 213 RAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKK 272
RRG +K+KA +++ A +++++S + VS
Sbjct: 146 ---RRG-----RKRKAEKQVETEE-----------------AGVVTTATASVNLKVS--- 177
Query: 273 PPRGRKPA-EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARR 331
P RGR A E +PKPRGR PK + P S SD ++E D+++++ E ++
Sbjct: 178 PKRGRPAATEVKIPKPRGR-PKMVKQPCPSESDIITEE----------DKSKKKGQEEKQ 226
Query: 332 RREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGR 391
++Q ++ E +KEE + R+E + +E + V+ + +
Sbjct: 227 PKKQP---KKDEEGQKEEDKPRKE----------------PDKKEGKKEVESKRKNLAKT 267
Query: 392 GPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARK--PGQKEKRVRPEEKQQAKPVKVER 449
G S+SDSE E + ++E +K K ++ T R GQ EK +++Q + ++ E+
Sbjct: 268 GVTSTSDSEEEGD-DQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQ 326
Query: 450 TRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVT 509
K +KVEKK+E S++ +LQ++H+EIK +LK+D+ DV RC+ AL+EL +LQVT
Sbjct: 327 QNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVT 386
Query: 510 SQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAV--QKVNKAGME 567
Q QK+T+++ TLKKIRR+K ++ +MEK+ +Y + K+ L + ++V Q +NK+ E
Sbjct: 387 MQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAE 446
Query: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
+ + EE ++ G++ P +K E + + S +NG + +Q G ++ G +E+
Sbjct: 447 QRQHEEANKTKD-QGKKGPNKKLEKEQTG--SKTLNGGSDAQDG----NQPQHNGESNED 499
Query: 628 GPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDS 664
S+D H E +P S+ +E E + DS
Sbjct: 500 ------SKDNH----EASTKKKPSSEERETEISLKDS 526
>gi|190014586 PC4 and SFRS1 interacting protein 1 isoform 1 [Homo
sapiens]
Length = 333
Score = 203 bits (516), Expect = 5e-52
Identities = 128/372 (34%), Positives = 187/372 (50%), Gaps = 56/372 (15%)
Query: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
M FKPGDL+FAKMKGYPHWPAR+D++ DGAVKPP NK PIFFFGTHETAFLGPKD+FP
Sbjct: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
Query: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
Y + K+KYGKPNKRKGFNEGLWEI NNP +S S + ++N + SD + ++
Sbjct: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFS------SQQAATKQSNAS--SDVEVEE 112
Query: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
++ V + D+D ++ + N + + ++R RK ++ Q
Sbjct: 113 KETSVS--------------KEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAE-KQV 157
Query: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
+ + ++S + K S + P V+ P+ P G K K P S+SD +
Sbjct: 158 ETEEAGVVTTATASVNLKVSPKRGRPAA-TEVKIPK--PRGRPKMVKQPCPSESDIITEE 214
Query: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE----- 295
D S KK G+K +KP +P ++ K E
Sbjct: 215 D-------------KSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKR 261
Query: 296 ----RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE 351
+ +S+SDS+ + D+ E KR+ R + RR + + EKE +
Sbjct: 262 KNLAKTGVTSTSDSEEEGDDQEGEKKRKG---GRNFQTAHRRNMLK-----GQHEKEAAD 313
Query: 352 RRRERADRGEAE 363
R+R++ ++ E E
Sbjct: 314 RKRKQEEQMETE 325
Score = 65.9 bits (159), Expect = 1e-10
Identities = 68/238 (28%), Positives = 115/238 (48%), Gaps = 41/238 (17%)
Query: 160 PALKMSVSKRARK---ASSDLD----QASVSPSEEENSESSSESEKTSDQDFTPEKKAAV 212
P +K S + A K ASSD++ + SVS + ++ E +S + T D T K A
Sbjct: 88 PKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAA-- 145
Query: 213 RAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKK 272
RRG +K+KA +++ A +++++S + VS
Sbjct: 146 ---RRG-----RKRKAEKQVETEE-----------------AGVVTTATASVNLKVS--- 177
Query: 273 PPRGRKPA-EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARR 331
P RGR A E +PKPRGR PK + P S SD ++E D+ S+ K ++E + ++ +
Sbjct: 178 PKRGRPAATEVKIPKPRGR-PKMVKQPCPSESDIITEE-DK-SKKKGQEEKQPKKQPKKD 234
Query: 332 RREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGR 389
Q+EE + +E +K+E ++ E + A+ G +S E DD+ +K+ + GR
Sbjct: 235 EEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGR 292
Score = 37.4 bits (85), Expect = 0.045
Identities = 50/231 (21%), Positives = 91/231 (39%), Gaps = 22/231 (9%)
Query: 285 PKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLRE 344
PK + + S++SSD + +E + + D + E + + R
Sbjct: 88 PKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARR 147
Query: 345 QEKEEKERRRERADRGEAERGSGGSS-------GDELREDDEPVKKRGRKGRGRGP-PSS 396
K + E++ E + G + + G + + K RGR + P PS
Sbjct: 148 GRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSE 207
Query: 397 SD-------SEPEAELEREAKKSAKKPQSSSTE---PARKPGQKE--KRVRPEEKQQAKP 444
SD S+ + + E++ KK KK + E P ++P +KE K V + K AK
Sbjct: 208 SDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKT 267
Query: 445 VKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKR 495
+ EG D++ EKK++ + + +K + ++ D KR
Sbjct: 268 GVTSTSDSEEEG--DDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKR 316
>gi|7705320 hepatoma-derived growth factor, related protein 3 [Homo
sapiens]
Length = 203
Score = 200 bits (508), Expect = 4e-51
Identities = 104/203 (51%), Positives = 124/203 (61%), Gaps = 23/203 (11%)
Query: 2 PHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPY 61
P +K GDLVFAKMKGYPHWPARID++ +GAVKPP NKYPIFFFGTHETAFLGPKDLFPY
Sbjct: 6 PREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPY 65
Query: 62 DKCKDKYGKPNKRKGFNEGLWEIQNNP---HASYSAPPPVSSSDSEAPEANPADGSDADE 118
+ KDK+GK NKRKGFNEGLWEI+NNP Y A SSS++E N AD S +E
Sbjct: 66 KEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADASSEEE 125
Query: 119 DDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLD 178
DR+E D + ++ +G KRK SK++RK+ D D
Sbjct: 126 ------------------GDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDED 167
Query: 179 QASVSPSEEENSESSSESEKTSD 201
EEEN SS + +D
Sbjct: 168 DKDC--KEEENKSSSEGGDAGND 188
>gi|4758516 hepatoma-derived growth factor isoform a [Homo sapiens]
Length = 240
Score = 167 bits (424), Expect = 2e-41
Identities = 91/214 (42%), Positives = 124/214 (57%), Gaps = 16/214 (7%)
Query: 5 FKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKC 64
+K GDLVFAKMKGYPHWPARID++ + AVK NKY +FFFGTHETAFLGPKDLFPY++
Sbjct: 10 YKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEES 69
Query: 65 KDKYGKPNKRKGFNEGLWEIQNNP---HASYSAPPPVSSSDSEAPEANPADGSDADEDDE 121
K+K+GKPNKRKGF+EGLWEI+NNP + Y + S + PE A+G D D+
Sbjct: 70 KEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAEG-DGDKKGN 128
Query: 122 DRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQAS 181
G ++ ++ D + + ++ LKR+ L KR ++A + +
Sbjct: 129 AEG--------SSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEK 180
Query: 182 VSPSEEENSESSSESEKTSDQDFTPEKKAAVRAP 215
+ + E E EK S TP + + R P
Sbjct: 181 EAATLEVERPLPMEVEKNS----TPSEPGSGRGP 210
Score = 38.1 bits (87), Expect = 0.027
Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 13/140 (9%)
Query: 227 KAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPK 286
KA S K+ + +PEP A ++ SSD + + ++ EK K
Sbjct: 96 KASGYQSSQKKSCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALK 155
Query: 287 PRG--------RKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEE 338
R ++PK P ++ + EV+R + + E + R QEEE
Sbjct: 156 RRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEE 215
Query: 339 LRRLREQEKEEKERRRERAD 358
E+E EE+E +E A+
Sbjct: 216 -----EEEDEEEEATKEDAE 230
Score = 35.4 bits (80), Expect = 0.17
Identities = 31/126 (24%), Positives = 51/126 (40%), Gaps = 6/126 (4%)
Query: 293 KPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKER 352
+PE P ++ D D +E +E + E + + ++ L+R E+ +
Sbjct: 111 EPEPEPEAAEGDGDKKGN---AEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPK 167
Query: 353 RRERADRGEAERGSGGSSGDE--LREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAK 410
R + A+ E E + E L + E G GRGPP + E E E E K
Sbjct: 168 RPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEE-EDEEEEATK 226
Query: 411 KSAKKP 416
+ A+ P
Sbjct: 227 EDAEAP 232
Score = 35.0 bits (79), Expect = 0.22
Identities = 38/141 (26%), Positives = 60/141 (42%), Gaps = 27/141 (19%)
Query: 348 EEKERRRERADRGEAERGSGGSSGDELRE--DDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
EE E E A+ ++G+ S DE + DEP K++ KG L
Sbjct: 110 EEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKG---------------AL 154
Query: 406 EREA----KKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSE-GFSMD 460
+R A + S K+P+ A P +EK E ++ P++VE+ SE G
Sbjct: 155 KRRAGDLLEDSPKRPKE-----AENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRG 209
Query: 461 RKVEKKKEPSVEEKLQKLHSE 481
E+++E EE+ K +E
Sbjct: 210 PPQEEEEEEDEEEEATKEDAE 230
Score = 32.0 bits (71), Expect = 1.9
Identities = 24/98 (24%), Positives = 38/98 (38%), Gaps = 16/98 (16%)
Query: 556 EAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDL----------------S 599
E ++ N+ G K +A + L +EA + E+K + L S
Sbjct: 143 EPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPS 202
Query: 600 APVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDL 637
P +G Q+ E ED+E E ++ E P E L
Sbjct: 203 EPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL 240
>gi|110681712 hepatoma derived growth factor-like 1 [Homo sapiens]
Length = 251
Score = 147 bits (372), Expect = 2e-35
Identities = 83/199 (41%), Positives = 110/199 (55%), Gaps = 27/199 (13%)
Query: 5 FKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKC 64
+K GDLVFAK+KGY HWPARI+ + PN+Y +FFFGTHETAFL PK LFPY +C
Sbjct: 9 YKSGDLVFAKLKGYAHWPARIEHMTQ------PNRYQVFFFGTHETAFLSPKRLFPYKEC 62
Query: 65 KDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVS---SSDSEAPEANPADGSDADEDDE 121
K+K+GKPNKR+GF+ GLWEI+NNP S P S S D PE A+G DE
Sbjct: 63 KEKFGKPNKRRGFSAGLWEIENNPTVQASDCPLASEKGSGDGPWPEPEAAEG------DE 116
Query: 122 DRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQAS 181
D+ A + + D D + LKR KR ++A+ D +
Sbjct: 117 DKPTHA-----GGGGDELGKPDDDKPTEEEKGPLKRSAGDPPEDAPKRPKEAAPDQE--- 168
Query: 182 VSPSEEENSESSSESEKTS 200
EE +E ++E+E+ +
Sbjct: 169 ----EEAEAERAAEAERAA 183
Score = 30.8 bits (68), Expect = 4.2
Identities = 22/79 (27%), Positives = 40/79 (50%), Gaps = 9/79 (11%)
Query: 355 ERADRGEAERGSGGSSGDEL--REDDEPV-KKRGRKGRGRGPPSS------SDSEPEAEL 405
E A+ E + G GDEL +DD+P +++G R G P ++ P+ E
Sbjct: 110 EAAEGDEDKPTHAGGGGDELGKPDDDKPTEEEKGPLKRSAGDPPEDAPKRPKEAAPDQEE 169
Query: 406 EREAKKSAKKPQSSSTEPA 424
E EA+++A+ ++++ A
Sbjct: 170 EAEAERAAEAERAAAAAAA 188
>gi|186928819 hepatoma-derived growth factor isoform b [Homo
sapiens]
Length = 256
Score = 129 bits (323), Expect = 1e-29
Identities = 74/197 (37%), Positives = 106/197 (53%), Gaps = 16/197 (8%)
Query: 22 PARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGL 81
P ID++ + AVK NKY +FFFGTHETAFLGPKDLFPY++ K+K+GKPNKRKGF+EGL
Sbjct: 43 PHTIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGL 102
Query: 82 WEIQNNP---HASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASD 138
WEI+NNP + Y + S + PE A+G D D+ G ++
Sbjct: 103 WEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAEG-DGDKKGNAEG--------SSDEEG 153
Query: 139 RMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEK 198
++ D + + ++ LKR+ L KR ++A + + + + E E EK
Sbjct: 154 KLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEK 213
Query: 199 TSDQDFTPEKKAAVRAP 215
S TP + + R P
Sbjct: 214 NS----TPSEPGSGRGP 226
Score = 38.1 bits (87), Expect = 0.027
Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 13/140 (9%)
Query: 227 KAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPK 286
KA S K+ + +PEP A ++ SSD + + ++ EK K
Sbjct: 112 KASGYQSSQKKSCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALK 171
Query: 287 PRG--------RKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEE 338
R ++PK P ++ + EV+R + + E + R QEEE
Sbjct: 172 RRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEE 231
Query: 339 LRRLREQEKEEKERRRERAD 358
E+E EE+E +E A+
Sbjct: 232 -----EEEDEEEEATKEDAE 246
Score = 35.4 bits (80), Expect = 0.17
Identities = 31/126 (24%), Positives = 51/126 (40%), Gaps = 6/126 (4%)
Query: 293 KPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKER 352
+PE P ++ D D +E +E + E + + ++ L+R E+ +
Sbjct: 127 EPEPEPEAAEGDGDKKGN---AEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPK 183
Query: 353 RRERADRGEAERGSGGSSGDE--LREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAK 410
R + A+ E E + E L + E G GRGPP + E E E E K
Sbjct: 184 RPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEE-EDEEEEATK 242
Query: 411 KSAKKP 416
+ A+ P
Sbjct: 243 EDAEAP 248
Score = 35.0 bits (79), Expect = 0.22
Identities = 38/141 (26%), Positives = 60/141 (42%), Gaps = 27/141 (19%)
Query: 348 EEKERRRERADRGEAERGSGGSSGDELRE--DDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
EE E E A+ ++G+ S DE + DEP K++ KG L
Sbjct: 126 EEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKG---------------AL 170
Query: 406 EREA----KKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSE-GFSMD 460
+R A + S K+P+ A P +EK E ++ P++VE+ SE G
Sbjct: 171 KRRAGDLLEDSPKRPKE-----AENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRG 225
Query: 461 RKVEKKKEPSVEEKLQKLHSE 481
E+++E EE+ K +E
Sbjct: 226 PPQEEEEEEDEEEEATKEDAE 246
Score = 32.0 bits (71), Expect = 1.9
Identities = 24/98 (24%), Positives = 38/98 (38%), Gaps = 16/98 (16%)
Query: 556 EAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDL----------------S 599
E ++ N+ G K +A + L +EA + E+K + L S
Sbjct: 159 EPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPS 218
Query: 600 APVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDL 637
P +G Q+ E ED+E E ++ E P E L
Sbjct: 219 EPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL 256
>gi|186928821 hepatoma-derived growth factor isoform c [Homo
sapiens]
Length = 233
Score = 127 bits (320), Expect = 3e-29
Identities = 74/196 (37%), Positives = 106/196 (54%), Gaps = 16/196 (8%)
Query: 23 ARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLW 82
A ID++ + AVK NKY +FFFGTHETAFLGPKDLFPY++ K+K+GKPNKRKGF+EGLW
Sbjct: 21 AVIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLW 80
Query: 83 EIQNNP---HASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDR 139
EI+NNP + Y + S + PE A+G D D+ G ++ +
Sbjct: 81 EIENNPTVKASGYQSSQKKSCVEEPEPEPEAAEG-DGDKKGNAEG--------SSDEEGK 131
Query: 140 MESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKT 199
+ D + + ++ LKR+ L KR ++A + + + + E E EK
Sbjct: 132 LVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKN 191
Query: 200 SDQDFTPEKKAAVRAP 215
S TP + + R P
Sbjct: 192 S----TPSEPGSGRGP 203
Score = 38.1 bits (87), Expect = 0.027
Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 13/140 (9%)
Query: 227 KAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPK 286
KA S K+ + +PEP A ++ SSD + + ++ EK K
Sbjct: 89 KASGYQSSQKKSCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALK 148
Query: 287 PRG--------RKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEE 338
R ++PK P ++ + EV+R + + E + R QEEE
Sbjct: 149 RRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEE 208
Query: 339 LRRLREQEKEEKERRRERAD 358
E+E EE+E +E A+
Sbjct: 209 -----EEEDEEEEATKEDAE 223
Score = 35.4 bits (80), Expect = 0.17
Identities = 31/126 (24%), Positives = 51/126 (40%), Gaps = 6/126 (4%)
Query: 293 KPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKER 352
+PE P ++ D D +E +E + E + + ++ L+R E+ +
Sbjct: 104 EPEPEPEAAEGDGDKKGN---AEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPK 160
Query: 353 RRERADRGEAERGSGGSSGDE--LREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAK 410
R + A+ E E + E L + E G GRGPP + E E E E K
Sbjct: 161 RPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEE-EDEEEEATK 219
Query: 411 KSAKKP 416
+ A+ P
Sbjct: 220 EDAEAP 225
Score = 35.0 bits (79), Expect = 0.22
Identities = 38/141 (26%), Positives = 60/141 (42%), Gaps = 27/141 (19%)
Query: 348 EEKERRRERADRGEAERGSGGSSGDELRE--DDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
EE E E A+ ++G+ S DE + DEP K++ KG L
Sbjct: 103 EEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKG---------------AL 147
Query: 406 EREA----KKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSE-GFSMD 460
+R A + S K+P+ A P +EK E ++ P++VE+ SE G
Sbjct: 148 KRRAGDLLEDSPKRPKE-----AENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRG 202
Query: 461 RKVEKKKEPSVEEKLQKLHSE 481
E+++E EE+ K +E
Sbjct: 203 PPQEEEEEEDEEEEATKEDAE 223
Score = 32.0 bits (71), Expect = 1.9
Identities = 24/98 (24%), Positives = 38/98 (38%), Gaps = 16/98 (16%)
Query: 556 EAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDL----------------S 599
E ++ N+ G K +A + L +EA + E+K + L S
Sbjct: 136 EPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPS 195
Query: 600 APVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDL 637
P +G Q+ E ED+E E ++ E P E L
Sbjct: 196 EPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL 233
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 94.7 bits (234), Expect = 2e-19
Identities = 135/588 (22%), Positives = 211/588 (35%), Gaps = 119/588 (20%)
Query: 60 PYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPP-----PVSSSDSEAPEANPADGS 114
P K K + + +E E+Q P + P P + ++A E++ ++ S
Sbjct: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEES 132
Query: 115 DADEDDED-------RGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVS 167
D+D+ED +GV SDSDSD SS++ K + P +
Sbjct: 133 SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
Query: 168 KRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKK 227
K KA +A+ + + + SSS S +S D + E+KAA + P KK+
Sbjct: 193 KAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVP----KKQV 248
Query: 228 APSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP 287
A P A + SSSS SSSD + KKP + + +P P
Sbjct: 249 VAKA-------------PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP 295
Query: 288 RGRKPKPE---RPPSSS--------SSDSDSDEVDRISEWKRRDEARRRELEARRRREQE 336
PK +PP + SS+ SDE D SE +++ + +A +
Sbjct: 296 SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355
Query: 337 EELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSS 396
++ AE S S D +D+ P K G
Sbjct: 356 KK----------------------AAESSSDSSDSDSSEDDEAPSKPAG----------- 382
Query: 397 SDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEG 456
K S+ KP ++ PA KP KQ + TRK
Sbjct: 383 -----------TTKNSSNKPAVTTKSPAVKPA-------AAPKQPVGGGQKLLTRKADSS 424
Query: 457 FSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKN 516
S E++ S EEK +K+ V + K A L Q +
Sbjct: 425 SS-----EEESSSSEEEKTKKM---------VATTKPKATAKAALSLPAKQAPQGSRDSS 470
Query: 517 TDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLA 576
+D ++ + K +K ++K + +V G A +K KAE +
Sbjct: 471 SDSDSSSSEEEEEKTSKSAVKKKPQ-------KVAG----GAAPSKPASAKKGKAESSNS 519
Query: 577 GEELAGEEAPQEKAEDKPSTDLSAP-VNGEA--TSQKGESAEDKEHEE 621
E +EK + K S AP NG + T+Q G++A++ E EE
Sbjct: 520 SSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEE 567
Score = 89.4 bits (220), Expect = 1e-17
Identities = 119/534 (22%), Positives = 204/534 (38%), Gaps = 70/534 (13%)
Query: 171 RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPS 230
RK ++ A + + +S+S SE+ + P KKAAV A R G G+ KA
Sbjct: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASE 125
Query: 231 ASDSDSKADSDGAKPE----------PVAMARSASSSSSSSSSSDSDVSVK-KPPRGRKP 279
+S S+ +D D + + P A A A + SS SDSD S + +PP+ +KP
Sbjct: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKP 185
Query: 280 AEKPL---------PKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEAR 330
P+ PKP PK ++SSS S S D++ + A
Sbjct: 186 KITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSS-------SSSDDSEEEKAAAT 238
Query: 331 RRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRG 390
++ ++ + K R+ + S SS DE E +P+K +
Sbjct: 239 PKKTVPKKQVVAKAPVKAATTPTRKSS-------SSEDSSSDEEEEQKKPMKNKPGPYSS 291
Query: 391 RGPPSS-------SDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAK 443
PPS+ P+ +E++ + + S ++ + + +K K K
Sbjct: 292 VPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTK 351
Query: 444 PVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEEL 503
P ++ + S S E + PS K +S K A+ SP VK + +
Sbjct: 352 PPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTK-NSSNKPAVTTKSPAVKPAAAPKQPV 410
Query: 504 GTLQ---------------VTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKS 548
G Q +S +K +VAT K KA + K A +R S
Sbjct: 411 GGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS 470
Query: 549 --RVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEA 606
E +K +K+ ++K+ +++AG AP + A K S+ N +
Sbjct: 471 SDSDSSSSEEEEEKTSKSAVKKKP-------QKVAGGAAPSKPASAKKGKAESS--NSSS 521
Query: 607 TSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERA 660
+ E E+K +G + P+ + L + + G + +E+++A
Sbjct: 522 SDDSSEEEEEKLKGKGSPRPQAPKANGTSAL--TAQNGKAAKNSEEEEEEKKKA 573
Score = 51.6 bits (122), Expect = 2e-06
Identities = 71/318 (22%), Positives = 132/318 (41%), Gaps = 39/318 (12%)
Query: 88 PHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVT----AVTATAASDR---- 139
P A +A SSDS++ E + A A AVT AV AA +
Sbjct: 353 PPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGG 412
Query: 140 ------MESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSP-----SEEE 188
++DS S + +S + KT + + +A ++ A +P S +
Sbjct: 413 GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSD 472
Query: 189 NSESSS--ESEKTSDQDF--TPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAK 244
+ SSS E EKTS P+K A AP + + K ++ ++S SD ++ + K
Sbjct: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
Query: 245 ------PEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPP 298
P P A + +S+ ++ + + S ++ +K A + K K +R
Sbjct: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNS-EEEEEEKKKAAVVVSKSGSLK---KRKQ 588
Query: 299 SSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERAD 358
+ ++ ++++ + +I +R++ E R RR+RE+E E R + +
Sbjct: 589 NEAAKEAETPQAKKIKLQTPNTFPKRKKGEKR----ASSPFRRVREEEIEVDSRVADNS- 643
Query: 359 RGEAERGSGGSSGDELRE 376
+A+RG+ G G+ +
Sbjct: 644 -FDAKRGAAGDWGERANQ 660
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 90.1 bits (222), Expect = 6e-18
Identities = 129/584 (22%), Positives = 239/584 (40%), Gaps = 71/584 (12%)
Query: 115 DADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLK-RKTPALKM--SVSKRAR 171
D+ +DD D +A A AA ++ S K + + LK +S A+
Sbjct: 11 DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQ 70
Query: 172 KASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSA 231
+D + +V P+E E +S+ +K Q + + + KK A
Sbjct: 71 GIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPK 130
Query: 232 SDSDSKADSD---GAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGR--------KPA 280
+ S +D D P+ S+ S D D S K R R +
Sbjct: 131 VEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDES 190
Query: 281 EKPLPKPRGRKPKPERPPSSS--SSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEE 338
++ L +G+K + P + S + D D +I ++ +A ++E E ++R E++ +
Sbjct: 191 DEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK-KAEKKERERKKRDEEKAK 249
Query: 339 LRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGP----- 393
LR+L+E+E+ E ++ +++ + E++R + ++E VK + G P
Sbjct: 250 LRKLKEKEELETGKK-DQSKQKESQR----------KFEEETVKSKVTVDTGVIPASEEK 298
Query: 394 ---PSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERT 450
P++++ + E + +++ KK KK + E +K G + V+ ++ AK + E
Sbjct: 299 AETPTAAEDDNEGDKKKKDKKK-KKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER 357
Query: 451 RKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTS 510
+KR E + R E + + EE+L++ E K K L++ G L S
Sbjct: 358 QKREEEERIKRLEELEAKRKEEERLEQEKRERK------KQKEKERKERLKKEGKLLTKS 411
Query: 511 QILQKNTDVVATLKKIRRYKA---NKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME 567
Q + ATLK ++ +KD + K +Y K + + ++E+ E
Sbjct: 412 Q-REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLES--------KE 462
Query: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKG-ESAEDKEHEEGRDSE 626
++ E A E+ + P EK E P + P E T G + E +E +
Sbjct: 463 VSESMELCAAVEVMEQGVP-EKEETPPPVE---PEEEEDTEDAGLDDWEAMASDEETEKV 518
Query: 627 EGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSEALDEE 670
EG + +H V+E P+ + +E E D E+ +EE
Sbjct: 519 EGNK------VHIEVKENPE-----EEEEEEEEEEEDEESEEEE 551
Score = 59.7 bits (143), Expect = 9e-09
Identities = 80/360 (22%), Positives = 131/360 (36%), Gaps = 47/360 (13%)
Query: 122 DRGVMAVT---AVTATAASDRMESDSDS-DKSSDNSGLKRKTPALKMSVSKRARKASSDL 177
D GV+ + A T TAA D E D DK + K K SK KA +
Sbjct: 288 DTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKA---M 344
Query: 178 DQASVSPSEEENSESSSESEKTSD-QDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDS 236
+A EEE + E E+ ++ ++K R + RKK+K +
Sbjct: 345 QEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKR--ERKKQKEKERKERLK 402
Query: 237 KADSDGAKPEPVAMARSASS----SSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP----- 287
K K + A AR+ ++ + D KK P K +P+
Sbjct: 403 KEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKE 462
Query: 288 ---------------RGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRR 332
+G K E PP + + E + +W+ E +
Sbjct: 463 VSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNK 522
Query: 333 REQEEELRRLREQEKEEKERRRERADRGEAERG-SGGSSGDELREDDEPVKKRGRKGRGR 391
E + E+E+EE+E E ++ E E G S GS GD E+DE V G+
Sbjct: 523 VHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD---EEDEKVSDEKDSGK-- 577
Query: 392 GPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTR 451
+ D +P E+ +++ + T+ R + ++R+ + +K V E+ R
Sbjct: 578 ----TLDKKPSKEMSSDSEYDS---DDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
Score = 37.0 bits (84), Expect = 0.059
Identities = 31/133 (23%), Positives = 54/133 (40%), Gaps = 17/133 (12%)
Query: 95 PPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSG 154
PPPV + E E D +A DE+ + V + E + + ++ ++
Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEE 546
Query: 155 LKRKTPALKMSVSKRARKASSDLDQASVSPSEEENS----------ESSSESEKTSDQDF 204
+ + + S+ D+ S+E++S E SS+SE SD D
Sbjct: 547 SEEEE-------EEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDR 599
Query: 205 TPEKKAAVRAPRR 217
T E++A +A RR
Sbjct: 600 TKEERAYDKAKRR 612
Score = 33.5 bits (75), Expect = 0.65
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 1/79 (1%)
Query: 101 SDSEAPEANPADGSDADEDDEDRGVMAVTAVTA-TAASDRMESDSDSDKSSDNSGLKRKT 159
S+ E E ++GS+ DE+DE + T S M SDS+ D D + +R
Sbjct: 547 SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAY 606
Query: 160 PALKMSVSKRARKASSDLD 178
K + KR + S +++
Sbjct: 607 DKAKRRIEKRRLEHSKNVN 625
>gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
Length = 710
Score = 84.7 bits (208), Expect = 2e-16
Identities = 84/353 (23%), Positives = 162/353 (45%), Gaps = 23/353 (6%)
Query: 111 ADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRA 170
A G + RG T V R+ DSD++ S + L ++ +S++KR
Sbjct: 22 AGGQEGSPGGGRRGSRGTTMVKKRKG--RVVIDSDTEDSGSDENLDQEL----LSLAKRK 75
Query: 171 RKASSDLDQASVSPSEEENSESS-SESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAP 229
R S + + P+ +SE+S S+ E T + +K A + ++G + + K A
Sbjct: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
Query: 230 S-ASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPR 288
S +SD DS A+S PE ++ S S+SSSSSS SDS ++ G + L
Sbjct: 136 SGSSDKDSSAESSA--PEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDG---YGEDLMGDE 190
Query: 289 GRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRR--------ELEARRRREQEEELR 340
+ + E+ + +++ KRR E +++ + E ++++E+E+E +
Sbjct: 191 EDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKK 250
Query: 341 RLRE-QEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPP-SSSD 398
+L + QE + +ER + + + + +EL+ + E K R + + P +S+
Sbjct: 251 KLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSE 310
Query: 399 SEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTR 451
+ E E E KS++K SS + ++++ + P+ + + P ++ R R
Sbjct: 311 VYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
Score = 47.8 bits (112), Expect = 3e-05
Identities = 68/312 (21%), Positives = 115/312 (36%), Gaps = 66/312 (21%)
Query: 100 SSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKT 159
S + E P + PA SD++ D D D S+ +K + K
Sbjct: 79 SEEKEPPVSQPAASSDSETSDSD---------------DEWTFGSNKNKKKGKARKIEKK 123
Query: 160 PALKMSVSKRARKASSDLDQAS---------VSPSEEENSESSSESEKTS-DQDFTP--- 206
+K +K A SSD D ++ VS S+ +S SSS+S+ +S D++F
Sbjct: 124 GTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYG 183
Query: 207 ---------------------EKKAAVRAPRRGPLGGR---KKK----KAPSASDSDSKA 238
E++ R +R L R KKK K + K
Sbjct: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQ 243
Query: 239 DSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGR------KP 292
+ + K + + S +S + S D + K + + + K + R K
Sbjct: 244 EEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKK 303
Query: 293 KPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKER 352
+P + S D + +E D+ SE + D + R + E++EE+ + +E
Sbjct: 304 QPLKTSEVYSDDEEEEEDDKSSE--KSDRSSRTS--SSDEEEEKEEIPPKSQPVSLPEEL 359
Query: 353 RRERADRGEAER 364
R R R + ER
Sbjct: 360 NRVRLSRHKLER 371
Score = 47.0 bits (110), Expect = 6e-05
Identities = 94/456 (20%), Positives = 163/456 (35%), Gaps = 103/456 (22%)
Query: 208 KKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSD 267
+ AA A PL G ++ S + S G R S + S SD +
Sbjct: 9 RAAAAAAAVAVPLAGGQE-----GSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDEN 63
Query: 268 VSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRREL 327
+ + ++ R + E P S ++ SDS+ D EW +++
Sbjct: 64 LDQELLSLAKRK--------RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKG 115
Query: 328 EARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRK 387
+AR+ E+K +++A++ + SG S D E P +
Sbjct: 116 KARKI---------------EKKGTMKKQANKTAS---SGSSDKDSSAESSAPEEGEVSD 157
Query: 388 GRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKV 447
SSSDS+ +E E + + AR EK E++Q ++
Sbjct: 158 SDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEK-----EREQELFNRI 212
Query: 448 ERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQ 507
E+ F + +K++ K+ +EK +K E K+ L ++E Q
Sbjct: 213 EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEE----------QEKKKLTQIQE---SQ 259
Query: 508 VTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME 567
VTS K RR K + + ++K ++ LK+ E
Sbjct: 260 VTSH------------NKERRSKRD-EKLDKKSQAMEELKA------------------E 288
Query: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
+EK + + A EL ++ P + +E S +++E E+ + SE+
Sbjct: 289 REKRKNRTA--ELLAKKQPLKTSE-------------------VYSDDEEEEEDDKSSEK 327
Query: 628 GPRCG--SSEDLHDSVREGPDLDRPGSDRQERERAR 661
R SS D + E P +P S +E R R
Sbjct: 328 SDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
Score = 44.3 bits (103), Expect = 4e-04
Identities = 62/299 (20%), Positives = 111/299 (37%), Gaps = 35/299 (11%)
Query: 29 ADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNP 88
+D K PP P + ++ D + + K+K K RK +G + Q N
Sbjct: 77 SDSEEKEPPVSQPA---ASSDSETSDSDDEWTFGSNKNKK-KGKARKIEKKGTMKKQANK 132
Query: 89 HASYSAPPPVSSSDSEAPE------------ANPADGSDADEDDEDRGVMAVTAVTATAA 136
AS + SS++S APE ++ +D + ED+E +
Sbjct: 133 TASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEED 192
Query: 137 SDRMESDSDSDKSSD-------------NSGLKRKTPALKMSVSKRARKASSDLDQASVS 183
R+E ++ ++ + +K+K K K +K + +
Sbjct: 193 RARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKL 252
Query: 184 PSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSD----SKAD 239
+E+ +S E+ S +D +KK+ + RK + A + S+
Sbjct: 253 TQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVY 312
Query: 240 SDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKP--LPKPRGRKPKPER 296
SD + E + S SS +SSSD + ++ P +P P L + R + K ER
Sbjct: 313 SDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 84.3 bits (207), Expect = 3e-16
Identities = 146/666 (21%), Positives = 255/666 (38%), Gaps = 61/666 (9%)
Query: 35 PPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSA 94
PP ++ P+ G H+ +++ +D GK ++ K E Q+
Sbjct: 388 PPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQ------- 440
Query: 95 PPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSG 154
SSS + P DG D + + R + S M S K S +
Sbjct: 441 ----SSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPR 496
Query: 155 LKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRA 214
R T + + R R+ + P E + + E++S + E + R+
Sbjct: 497 DSRST---RDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRS 553
Query: 215 PRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPP 274
R GR + + P + S+ + + S + SS + D ++
Sbjct: 554 EIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDN 613
Query: 275 RG--------RKPAEKPLPKPRGRKPKPERP--PSSSSSDSDSDE------VDRISEWKR 318
R R+ E+ R R +P P + + + DE VDR+ + R
Sbjct: 614 RDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDD--R 671
Query: 319 RDEARR---RELEARRRREQEEELRRLREQEKE---------EKERRRERADRGEAERGS 366
RDE R RE E R RE+E E R RE+EKE E+ER RE+ E +R
Sbjct: 672 RDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDR 731
Query: 367 GGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARK 426
E + + K+R R+ R + E E E ERE +++ ++ + + +
Sbjct: 732 DHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWE 791
Query: 427 PGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFAL 486
K + R E++++ + + R + E P K ++ HS A
Sbjct: 792 DKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDA- 850
Query: 487 KVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRL 546
+S D K N L + V Q + + T + R+K +D + E R
Sbjct: 851 -YNSGDDK---NEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWK-EEDRKPERKESSRRY 905
Query: 547 KSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVN-GE 605
+ + L K+ +V K ++E+ E + A + ++ED+ ++D + N +
Sbjct: 906 EEQELKEKVSSVDK------QREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKK 959
Query: 606 ATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSE 665
A QK + KE + G E G +SED V + S ++R++++GDS+
Sbjct: 960 AKIQKKPIKKKKEDDVG--IERGNIETTSED--GQVFSPKKGQKKKSIEKKRKKSKGDSD 1015
Query: 666 ALDEES 671
DEE+
Sbjct: 1016 ISDEEA 1021
Score = 59.7 bits (143), Expect = 9e-09
Identities = 98/419 (23%), Positives = 145/419 (34%), Gaps = 70/419 (16%)
Query: 115 DADEDDEDRGVMAVTAVTATAAS-DRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKA 173
+ + DD D G + V + R + + K + KR+ +K VS ++
Sbjct: 145 ETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRS 204
Query: 174 ----SSDLDQASVSPSEEENSESSSESEKTS--------------DQDFTPEKKAAVRAP 215
S L ++S SP + + +SSS S+K + KK R P
Sbjct: 205 KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTP 264
Query: 216 RRGP------LGGRKKKKAPSASDSDSKADSDGA--------------KPE---PVAMAR 252
P G+K K+ D + DG KP P
Sbjct: 265 SPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHH 324
Query: 253 SASSSSSSSSSSDSDVSVKK----PPRGRKPA---EKPLPKP--RGRKPKPERPPSSSSS 303
S SS SSSS S S+++ P R R P+ ++ L P R P P SS
Sbjct: 325 SPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQR 384
Query: 304 DSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAE 363
K R + R RR E+ E+ R R++EK+ +E R D+
Sbjct: 385 KQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQ---- 440
Query: 364 RGSGGSSGDELREDDEPVKKRGRKGRG--------RGPPSSSDSEPEAELEREAKKSAKK 415
SS + R+D EP R R+ R DS + R+ K+S
Sbjct: 441 -----SSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDP 495
Query: 416 PQSSSTEPARKPGQKEKR--VRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVE 472
S ST A +E R R E+ + R R E + + E + E E
Sbjct: 496 RDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSE 554
Score = 50.4 bits (119), Expect = 5e-06
Identities = 80/395 (20%), Positives = 146/395 (36%), Gaps = 39/395 (9%)
Query: 116 ADEDDEDRGVMAVTAVTATAASDRMESD------------SDSDKSSDNSGLKRKTPALK 163
+DED DR + TATA + + + ++ + L T A
Sbjct: 1068 SDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAA 1127
Query: 164 MSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGR 223
S S A S+ + + + N +S + +T + A R P+
Sbjct: 1128 TSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMD-- 1185
Query: 224 KKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKP 283
+K+ + S+ +++ + G RS S+ S+ S D + G + EK
Sbjct: 1186 QKRSSSLGSNRSNRSHTSGR-------LRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKT 1238
Query: 284 --LPKPRGRKPK--------PERPPSSSSSDSDSDEVDRIS-EWKRRDEARRRELEARRR 332
L RK + P R SS DS S R S E R+ +R ++R R
Sbjct: 1239 KSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDR 1298
Query: 333 REQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRG 392
++ + RE+E+E ++ R+ DR + D LRE + ++ R+ R
Sbjct: 1299 LQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRE 1358
Query: 393 PPSSSDSEPEAELEREAKKSAKKPQSSSTE--PARKPGQKEKRVRPEEKQQ--AKPVKVE 448
E + +R+ ++ + Q S + A+ G+ E+ + + +++
Sbjct: 1359 RERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMD 1418
Query: 449 RTRKRSEGFSMDRKVEKKKEPSV---EEKLQKLHS 480
+ +GF K E+ + E KL HS
Sbjct: 1419 KDLGSVQGFEETNKSERTESLEAGDDESKLDDAHS 1453
Score = 45.4 bits (106), Expect = 2e-04
Identities = 104/550 (18%), Positives = 187/550 (34%), Gaps = 70/550 (12%)
Query: 137 SDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQ-------ASVSPSEEEN 189
S + S KSS S RKT A+ + + R + ++ + + P E+
Sbjct: 215 SSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDI 274
Query: 190 SESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVA 249
+ EK +D EK R G GR ++ D G P++
Sbjct: 275 ALGKKYKEKYKVKDRIEEKT------RDGKDRGRDFERQREKRDKPRSTSPAGQHHSPIS 328
Query: 250 MARSASSSSSSSSSSDSDVSVKKPPRGRKPA---EKPLPKPRGRKPKPERPPSSSSSDSD 306
+SSS S SS S P R R P+ ++ L P R P S SS
Sbjct: 329 SRHHSSSSQSGSSIQRHSPS---PRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSP--- 382
Query: 307 SDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGS 366
+R++ R R E+ R E+ + +RR ER + +R
Sbjct: 383 ----------------QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDR 426
Query: 367 GGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARK 426
S +E + + R + D EP +R + + + +
Sbjct: 427 EKDSREEREYEQDQSSSRDHR---------DDREPRDGRDRRDARDTRDRRELRDSRDMR 477
Query: 427 PGQKEKRVRPEEKQQAKPVKVERTR-----KRSEGFSMDRKVEKKKEPSVEEKLQKLHSE 481
++ + + K+ P TR + EG RK + E S L E
Sbjct: 478 DSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREE 537
Query: 482 -IKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA 540
+ ++ +S + R + +G + L + + +I + +N +
Sbjct: 538 SSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSN-------S 590
Query: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSA 600
+ ++R P+ + + + ++ + E+ GE + + + +P S+
Sbjct: 591 NYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGER---DRRDNRERDQRP----SS 643
Query: 601 PVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERA 660
P+ + + E D+ EE R R D RE D +R +ER+R
Sbjct: 644 PIRHQ--GRNDELERDERREERRVDRVDDRRDERARERDRERE-RDRERERERERERDRE 700
Query: 661 RGDSEALDEE 670
R L+ E
Sbjct: 701 REKERELERE 710
Score = 38.1 bits (87), Expect = 0.027
Identities = 69/364 (18%), Positives = 127/364 (34%), Gaps = 34/364 (9%)
Query: 136 ASDRMESDSDSDKSSDNSGLKRKTPALKMSVS---KRARKASSDLDQASVSPSEEENSES 192
+ DR SD D++ + +++K K +R ++ D SP + + +S
Sbjct: 943 SEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKS 1002
Query: 193 SSESEKTS--DQDFTPEKKAAVRAPRRGP---------------------LGGRKKKKAP 229
+ K S D D + E+ A +RGP L +KK+
Sbjct: 1003 IEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDT 1062
Query: 230 SASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRG 289
+ SD + D + E +A++++ S+ S + PP +P
Sbjct: 1063 AFSDWSDEDVPD--RTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLA 1120
Query: 290 RKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLR-EQEKE 348
S+S+ + S + + R R ++ E + E +
Sbjct: 1121 ATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQH 1180
Query: 349 EKERRRERADRGEAERGSGGSSGDELREDDEPVKKRG---RKGRGRGPPSSS-DSEPEAE 404
K ++R+ + R + + LR R + GR R S S D E
Sbjct: 1181 RKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKS 1240
Query: 405 LEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGF-SMDRKV 463
LE ++ ++ Q EP+R + R +++ P + RS F S DR
Sbjct: 1241 LEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ 1300
Query: 464 EKKK 467
E+ +
Sbjct: 1301 ERDR 1304
Score = 37.7 bits (86), Expect = 0.035
Identities = 62/282 (21%), Positives = 113/282 (40%), Gaps = 44/282 (15%)
Query: 385 GRKGRGRGPPSS---SDSEPEAELEREAKKSAK----KPQSSSTEPARKPGQKE-KRVRP 436
G RG+G S+ S P +L K + +PQ +TE + P +KE R R
Sbjct: 62 GPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRH 121
Query: 437 EEKQQAKPVK----------VERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFAL 486
EK+ K K VE R + + D + E S+E K QK+ E+ +
Sbjct: 122 REKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQREL---M 178
Query: 487 KVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRY-KANKDVMEKAAEVYTR 545
K++ ++++ E + +V+ ++++ +L+K + K +A R
Sbjct: 179 KLEQENMEK---REEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDR 235
Query: 546 LKSRVLGPKIEAVQKVNKAGMEKEKAEEKLA-----GEELAGEEAPQEKAEDKPSTDLSA 600
S V P ++ Q+ +K K+K + E++A + +EK + K
Sbjct: 236 KTSAVSSPLLDQ-QRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVK------- 287
Query: 601 PVNGEATSQKGESAED--KEHEEGRDSEEGPRCGSSEDLHDS 640
+ +K +D ++ E R+ + PR S H S
Sbjct: 288 ----DRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHS 325
Score = 32.3 bits (72), Expect = 1.5
Identities = 83/415 (20%), Positives = 141/415 (33%), Gaps = 63/415 (15%)
Query: 285 PKPRGR------KPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEE 338
P PRG+ + PERP + D +E ++R+ E + R+E
Sbjct: 63 PSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNT---EESSSPVRKESS-- 117
Query: 339 LRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSD 398
R R +EKE+ + +ER E E ++ D+ D + D
Sbjct: 118 --RGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGD----------------INYD 159
Query: 399 SEPEAELEREAKKSAKKPQSSSTEPARKPGQ--KEKRVRPEE-----------KQQAKPV 445
E LE + +K ++ E K + +K V PE ++ +K
Sbjct: 160 YVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSP 219
Query: 446 KVERTRKRSEGFSMDRKVEKKKEPSV-EEKLQKLHSEIKFALKVDSP------DVKRCLN 498
K + + K S DRK P + +++ K + K + SP D+
Sbjct: 220 KRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKK 279
Query: 499 ALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKD---VMEKAAEVYTRLKSRVLGPKI 555
E+ +V +I +K D + R + +D A + ++ + SR
Sbjct: 280 YKEK---YKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSS 336
Query: 556 EAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAE 615
++ + + + + + A PS LS+P Q
Sbjct: 337 QSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSP----QRKQSPPRHR 392
Query: 616 DKEHEEGRDSEEGPRCGSSEDLHDSVREGP--DLDRPGSDRQERERARGDSEALD 668
E+GR E R S D RE DR R+ERE + S + D
Sbjct: 393 SPMREKGRHDHE--RTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRD 445
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 84.0 bits (206), Expect = 4e-16
Identities = 118/455 (25%), Positives = 173/455 (38%), Gaps = 87/455 (19%)
Query: 88 PHASYSAPPPVSSSDSEAPEAN-----PADGSDADEDDEDRGVMAVTAV----------- 131
P A P P S S S +PE N P E D+ +A T +
Sbjct: 1486 PKALPQTPRPRSRSPS-SPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQE 1544
Query: 132 --TATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASS-DLDQAS-VSPSEE 187
+AS + S+SDS S +S K +TP + +R+R SS ++D S +SP
Sbjct: 1545 LDVKPSASPQERSESDS---SPDSKAKTRTP-----LRQRSRSGSSPEVDSKSRLSPRRS 1596
Query: 188 ENSESSSESEKT-------SDQDFTPEKKA-AVRA-PRRGPLGGRKKKKAPSASDSDSKA 238
+ S +K S D +PE KA A RA PRR G K + PS S S
Sbjct: 1597 RSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTE 1656
Query: 239 DS-------------DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLP 285
S + PEP +R+ SS SS + + R R + P
Sbjct: 1657 SSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPET 1716
Query: 286 KPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEE---LRRL 342
+ R P+ R PS SS + E R S +R + R + +RR R + L+R
Sbjct: 1717 RSR-TPPRHRRSPSVSSPEPA--EKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRS 1773
Query: 343 REQEKEEKERRRERADRGEAER---------------------GSGGSSGDELREDDEPV 381
R + + EK R R DR + + GSG S R++
Sbjct: 1774 RSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRT 1833
Query: 382 KKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKK--PQSSSTEPARKPGQKEKRVRPEEK 439
R R+GR R PP+S K+S + P + +R P +R R
Sbjct: 1834 SSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSR---- 1889
Query: 440 QQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEK 474
+ PV R+R R+ S+ R+ + + V +
Sbjct: 1890 SRTSPVSRRRSRSRT---SVTRRRSRSRASPVSRR 1921
Score = 80.5 bits (197), Expect = 5e-15
Identities = 87/295 (29%), Positives = 115/295 (38%), Gaps = 34/295 (11%)
Query: 99 SSSDSEAPEANPADG---SDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGL 155
S+ D + PA G SD E G +A+ A + S S S SS +S
Sbjct: 2486 SAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSS- 2544
Query: 156 KRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAP 215
S + +SS +S S SE + E TP K AVR
Sbjct: 2545 -----------SSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREG 2593
Query: 216 RRG-PLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPP 274
R P ++K+++ S+S S S + S + + + S+SSSSSSSSSS S S P
Sbjct: 2594 RPPEPTPAKRKRRSSSSSSSSSSSSSSSSS----SSSSSSSSSSSSSSSSSSSSSSSSSP 2649
Query: 275 RGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRRE 334
KP + LPKP K KP PP S S +D + RD RRR
Sbjct: 2650 SPAKPGPQALPKPASPK-KP--PPGERRSRSPRKPIDSL-----RDSRSLSYSPVERRRP 2701
Query: 335 QEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGR 389
+ R+Q+ ER R RG+ S S RE P R R R
Sbjct: 2702 SPQP--SPRDQQSSSSERGSRRGQRGD----SRSPSHKRRRETPSPRPMRHRSSR 2750
Score = 78.6 bits (192), Expect = 2e-14
Identities = 94/430 (21%), Positives = 159/430 (36%), Gaps = 40/430 (9%)
Query: 76 GFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATA 135
GF+ + E N P + P ++ ++ S+ D ++ M+ ++
Sbjct: 1346 GFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSP 1405
Query: 136 ASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSD-LDQASVSPSEEENSESS- 193
D + ++SS S + K L + S+R+R SS L S +PS S SS
Sbjct: 1406 VLDAVPRTPSRERSSSASSPEMKD-GLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSP 1464
Query: 194 -------SESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSK--------A 238
+ S S+ D +PE KA + P R + ++PS+ + ++K +
Sbjct: 1465 GMKDIPRTPSRGRSECDSSPEPKALPQTP-------RPRSRSPSSPELNNKCLTPQRERS 1517
Query: 239 DSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPP 298
S+ + + S S SS + DV P+ R ++ P + + P R
Sbjct: 1518 GSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSS-PDSKAKTRTPLRQR 1576
Query: 299 SSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERAD 358
S S S + D R+S + R + + R + + + K R R
Sbjct: 1577 SRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRS 1636
Query: 359 R-GEAERGSG----GSSGDELREDDEPVKKRGRKG---------RGRGPPSSSDSEPEAE 404
R G + +G G GSS E + P + R+G + R PP S E
Sbjct: 1637 RSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPE 1696
Query: 405 LEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVE 464
L R+A+ S + +SS+ R R P K +R+R S K
Sbjct: 1697 LTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTT 1756
Query: 465 KKKEPSVEEK 474
++ S K
Sbjct: 1757 SRRGRSPSPK 1766
Score = 61.2 bits (147), Expect = 3e-09
Identities = 72/323 (22%), Positives = 117/323 (36%), Gaps = 26/323 (8%)
Query: 148 KSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPE 207
+S G R + S+ AR+ S S SP+ S S + + + + TP
Sbjct: 535 RSPQRPGWSRSRNTQRRGRSRSARRGRSH----SRSPATRGRSRSRTPARRGRSRSRTPA 590
Query: 208 KKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSD 267
++ R+ R P R + + P+ + + R S S S + S
Sbjct: 591 RR---RSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRS 647
Query: 268 VSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRREL 327
S RGR + P + R R P R S S + + S RR +R R L
Sbjct: 648 RSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSL 707
Query: 328 EARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRK 387
R R RR R E++ + ++R S +S E+++ + R+
Sbjct: 708 VRRGRSHSRTPQRRGRSGSSSERKNKSR-----TSQRRSRSNSSPEMKKS----RISSRR 758
Query: 388 GRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKV 447
R P S ++ L R S+ P+ S P R+ + +P+ K + P
Sbjct: 759 SRSLSSPRSK-AKSRLSLRRSLSGSSPCPKQKSQTPPRR--SRSGSSQPKAKSRTPP--- 812
Query: 448 ERTRKRSEGFSMDRKVEKKKEPS 470
+RS S +K K PS
Sbjct: 813 ----RRSRSSSSPPPKQKSKTPS 831
Score = 54.7 bits (130), Expect = 3e-07
Identities = 77/380 (20%), Positives = 123/380 (32%), Gaps = 34/380 (8%)
Query: 94 APPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNS 153
A P S ++PE P S + T S S +S K +
Sbjct: 397 ASPTRDRSPPKSPEKLPQSSSSESSPPSPQ---------PTKVSRHASSSPESPKPAPAP 447
Query: 154 GLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVR 213
G R+ + S ++ +A D + S S + +++ + TP K+ R
Sbjct: 448 GSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSR 507
Query: 214 APRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSS---SSSSSSDSDVSV 270
+ R P R + + P+ +RS ++ S S+ S
Sbjct: 508 S--RSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSR 565
Query: 271 KKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEAR 330
RGR + P + R R P R S S + + R + R +R
Sbjct: 566 SPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRT----PA 621
Query: 331 RRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELR---EDDEPVKKRG-- 385
RRR + R R + + R R A RG S R P ++ G
Sbjct: 622 RRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRS 681
Query: 386 ------RKGRGRGPPSSSDSEPEAELEREAKKSAKKPQ-----SSSTEPARKPGQKEKRV 434
R+GR R L R + ++ PQ SS+E K ++R
Sbjct: 682 RSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRS 741
Query: 435 RPEEKQQAKPVKVERTRKRS 454
R + K ++ R RS
Sbjct: 742 RSNSSPEMKKSRISSRRSRS 761
Score = 52.4 bits (124), Expect = 1e-06
Identities = 56/256 (21%), Positives = 97/256 (37%), Gaps = 15/256 (5%)
Query: 205 TPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSS 264
TP ++ AV + KK + A+ S + DG+ +P AR A +
Sbjct: 111 TPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKP 170
Query: 265 DSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARR 324
S V R + P PK + +K K +R S SS + + K R E+
Sbjct: 171 YSLV------RESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESES 224
Query: 325 RELEAR------RRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDD 378
++ + R +R+ ++++ +R R K RR R+ ++ S +S R
Sbjct: 225 KKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSA-SSSDTSRSRSRSAA 283
Query: 379 EPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEE 438
GR P S E +A S ++P SS E A K + ++
Sbjct: 284 AKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRP--SSPETATKQPSSPYEDKDKD 341
Query: 439 KQQAKPVKVERTRKRS 454
K++ + + +RS
Sbjct: 342 KKEKSATRPSPSPERS 357
Score = 49.3 bits (116), Expect = 1e-05
Identities = 77/395 (19%), Positives = 131/395 (33%), Gaps = 34/395 (8%)
Query: 95 PPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSG 154
P P S + +P + +DRG + ++ + +R +S S++
Sbjct: 168 PKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESS---SPRRERKKSSKKKKHRSESES 224
Query: 155 LKRK----TPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKA 210
KRK TP K + RK S A S + +S++S +SD + + A
Sbjct: 225 KKRKHRSPTPKSKRKSKDKKRKRSRSTTPAP--KSRRAHRSTSADSASSSDTSRSRSRSA 282
Query: 211 AVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEP-VAMARSASSSSSSSSSSDSDVS 269
A + L GR A S + + D EP + SS +++ S
Sbjct: 283 AAKT-HTTALAGRSPSPA-----SGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYE 336
Query: 270 VKKPPRGRKPAEKPLPKPRGRKPKPERP---PSSSSSDSDSDEVDRISEWKRRDEARRRE 326
K + K A +P P P PE P P + S + + + E
Sbjct: 337 DKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSE 396
Query: 327 LEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSS-------GDELREDDE 379
R R + +L + E + + S S G
Sbjct: 397 ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSS 456
Query: 380 PVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEP-------ARKPGQKEK 432
P K GR + S S + + +AK+ +S S P +R P +
Sbjct: 457 PTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRS 516
Query: 433 RVRPEEKQQAKPVKVERTRK-RSEGFSMDRKVEKK 466
R + P + R+R + G+S R +++
Sbjct: 517 RSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRR 551
Score = 48.9 bits (115), Expect = 2e-05
Identities = 94/442 (21%), Positives = 158/442 (35%), Gaps = 78/442 (17%)
Query: 86 NNPHASYSAP---PPVSSSDSEAPEANPA-DGSDADEDDEDRGVMAVTAVTATAASDRME 141
++P AP P S S S + P+ +GS + E + + TA + +S +
Sbjct: 1620 SSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPK 1679
Query: 142 SDSDSDKSSDNSGLKRKTPAL--KMSVSKRARKASSDLDQASVSPSEEENSESSSESEKT 199
+ S + +S R +P L K +S+R+R ASS + S +P S S S E
Sbjct: 1680 TKSRTPPRRRSS---RSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPA 1736
Query: 200 SDQDFTPEKKAAV-----------RAPRRGPLG---------------GRKKKKAPSASD 233
+ +++A R+P P G R++ ++ S+
Sbjct: 1737 EKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQS 1796
Query: 234 SDSKADSDGAKPEPVAMARSASS---------SSSSSSSSDSDVSVKKPPRGRKPAEK-- 282
+ + ++ R S SS +SS + PP RK +
Sbjct: 1797 TSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRT 1856
Query: 283 -PLP--------------KPRGRKP--KPERPPSSSSSDSDSDEVDRISEWKRRDEARRR 325
P P + R R P R S +S S R S +RR +R
Sbjct: 1857 SPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRAS 1916
Query: 326 ELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDEL-----REDDEP 380
+ RR R + + R R + + RRR R+ R S + R P
Sbjct: 1917 PVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSP 1976
Query: 381 VKKRGRKGRGRGPP-----SSSDSEPEAELEREAKKS--AKKPQSSSTEPA-RKPGQKEK 432
+ + R+ R R P S S + P ++ S ++ S T PA R+ +
Sbjct: 1977 ITR--RRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRT 2034
Query: 433 RVRPEEKQQAKPVKVERTRKRS 454
+ P ++ +++ R R RS
Sbjct: 2035 PLLPRKRSRSRSPLAIRRRSRS 2056
Score = 48.5 bits (114), Expect = 2e-05
Identities = 75/311 (24%), Positives = 107/311 (34%), Gaps = 66/311 (21%)
Query: 144 SDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQD 203
SD + ++G ++ + + +K R +SS +S S S +S SSS S +S
Sbjct: 2504 SDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDS 2563
Query: 204 FTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSS 263
E + P K+ PS + + +A +G PEP R SSSSSSSS
Sbjct: 2564 ---EGSSLPVQPEVA------LKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSS 2614
Query: 264 SDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEAR 323
S S S + SSSSS S S S K +A
Sbjct: 2615 SSSSSSSSSSSSSSSSSSSS---------------SSSSSSSSSSSSSSPSPAKPGPQA- 2658
Query: 324 RRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKK 383
L + +K RR R+ R + S D PV++
Sbjct: 2659 ---------------LPKPASPKKPPPGERRSRSPRKPID-----SLRDSRSLSYSPVER 2698
Query: 384 RGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAK 443
R R PS D QSSS+E + GQ+ P K++ +
Sbjct: 2699 R----RPSPQPSPRDQ-----------------QSSSSERGSRRGQRGDSRSPSHKRRRE 2737
Query: 444 PVKVERTRKRS 454
R RS
Sbjct: 2738 TPSPRPMRHRS 2748
Score = 43.1 bits (100), Expect = 8e-04
Identities = 96/433 (22%), Positives = 155/433 (35%), Gaps = 77/433 (17%)
Query: 93 SAPPPVSS---SDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKS 149
S PP ++ S S P+A PA + A + TAA+ S + + +
Sbjct: 2314 SGTPPTAANYPSSSRTPQA-PASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMA 2372
Query: 150 SDNSGLKRKTPALKMSVSKRARKASSD--LDQASVSPSEEENSESSSESEKTSDQDFTPE 207
SG +P + +S +R +S LD+A + S+S TS++ +P
Sbjct: 2373 PALSGANLTSPRVPLSAYERVSGRTSPPLLDRAR----SRTPPSAPSQSRMTSERAPSPS 2428
Query: 208 KKAAVRAPRRG---PLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASS-----SSS 259
+ +AP + P + + PSA S+ A+ PVA ++S SS ++S
Sbjct: 2429 SRMG-QAPSQSLLPPAQDQPRSPVPSAFSDQSRCLI--AQTTPVAGSQSLSSGAVATTTS 2485
Query: 260 SSSSSDSDVSVKKP-----PRGRKPAEKPLPKPRGR---KPKPERPPSSSSSDSDSDEVD 311
S+ + +SV P G PA +P +P ER SSSSS S S
Sbjct: 2486 SAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSS 2545
Query: 312 RISEWKRRDEAR-------------RRELEARR----RREQEEELRRLREQEKEEKERRR 354
S + + E+ +R +E +R R E +R+R
Sbjct: 2546 SSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKR 2605
Query: 355 ERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAK 414
+ + S SS SSS S + + S+
Sbjct: 2606 RSSSSSSSSSSSSSSSS-----------------------SSSSSSSSSSSSSSSSSSSS 2642
Query: 415 KPQSSSTEPARKPGQK-------EKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKK 467
SSS PA KPG + K+ P E++ P K + + S S ++
Sbjct: 2643 SSSSSSPSPA-KPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRP 2701
Query: 468 EPSVEEKLQKLHS 480
P + Q+ S
Sbjct: 2702 SPQPSPRDQQSSS 2714
Score = 42.7 bits (99), Expect = 0.001
Identities = 62/307 (20%), Positives = 116/307 (37%), Gaps = 30/307 (9%)
Query: 346 EKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPP--------SSS 397
E EK+ R RA G ++ GSS D R + R K PP SSS
Sbjct: 126 ELNEKKNERLRAAFGISDSYVDGSSFDPQR------RAREAKQPAPEPPKPYSLVRESSS 179
Query: 398 DSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGF 457
P + +++ KK + +S S+ P R+ + K+ + + ++K K +S+
Sbjct: 180 SRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRK 239
Query: 458 SMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNT 517
S D+K ++ + + K ++ H A S D R + T T+ + ++
Sbjct: 240 SKDKKRKRSRSTTPAPKSRRAHRSTS-ADSASSSDTSRSRSRSAAAKT--HTTALAGRSP 296
Query: 518 DVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAG 577
+ RR + + E R S K + +K +KEK+ + +
Sbjct: 297 SPASG----RRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSP 352
Query: 578 EELAGEEAPQ---------EKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEG 628
P+ E+ P + P++ E + E++ ++ + E+
Sbjct: 353 SPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKL 412
Query: 629 PRCGSSE 635
P+ SSE
Sbjct: 413 PQSSSSE 419
Score = 42.4 bits (98), Expect = 0.001
Identities = 46/186 (24%), Positives = 75/186 (40%), Gaps = 21/186 (11%)
Query: 146 SDKSSDNSGLKRKTPALKMSVSKRARKASSDLD-QASVSPSEEENSESSSESEKTSDQDF 204
S S K +TP +R+R +SS Q S +PS + +S SS + S
Sbjct: 797 SRSGSSQPKAKSRTPP------RRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSG--- 847
Query: 205 TPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSS 264
TP ++ ++ +P+ A S + + + P+P +R+ S S S SS
Sbjct: 848 TPPRQGSITSPQ-----------ANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSP 896
Query: 265 DSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARR 324
S P + + P PK + +R S SSS S S R + + R +
Sbjct: 897 PRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPC 956
Query: 325 RELEAR 330
+E+R
Sbjct: 957 SNVESR 962
Score = 41.2 bits (95), Expect = 0.003
Identities = 95/402 (23%), Positives = 142/402 (35%), Gaps = 66/402 (16%)
Query: 91 SYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSS 150
S S+PP V SS P +P+ S V A+ S R S S S S
Sbjct: 892 SGSSPPRVKSSTP--PRQSPSRSSSPQPK--------VKAII----SPRQRSHSGSSSPS 937
Query: 151 DNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSES--EKTSDQDFTPEK 208
+ R TP SVS + S L + S S S +++ E+ ++ +P
Sbjct: 938 PSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYP 997
Query: 209 KAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDV 268
K + P GP K P DS S P +++ SS+ S
Sbjct: 998 KVKAQTP-PGPSLSGSKSPCPQEKSKDSLVQS---CPGSLSLCAGVKSSTPPGESYFGVS 1053
Query: 269 SVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELE 328
S++ K + P R SD+ S EV R+ + L+
Sbjct: 1054 SLQ-----LKGQSQTSPDHR--------------SDTSSPEV-------RQSHSESPSLQ 1087
Query: 329 ARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKG 388
++ + + R E R R DRGE S+ L+ P + R +
Sbjct: 1088 SKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEF------SASPMLKSGMSPEQSRFQSD 1141
Query: 389 RGRGPPSSSDS---EPEAELEREAKKSAKKPQSSSTEPARKPGQKEK------RVRPEEK 439
P S+S + E +K A PQ +T A P QK+K + RPE
Sbjct: 1142 SSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDAT--ASPPRQKDKFSPFPVQDRPESS 1199
Query: 440 QQAKPVKVERTRKRS-EGFSMDRKVEKKKEP--SVEEKLQKL 478
K R+RS G S + K + P S +E+L ++
Sbjct: 1200 LVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEV 1241
Score = 32.0 bits (71), Expect = 1.9
Identities = 82/334 (24%), Positives = 120/334 (35%), Gaps = 63/334 (18%)
Query: 315 EWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRER-ADRGEAERGSGG----S 369
E KRR E R ELE EQ E ++++E+ + E+ + G E G +
Sbjct: 61 ERKRRVELRCLELE-EMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVT 119
Query: 370 SGDELREDDEPVKKRGRKGRGRGPP----SSSDSEPEAELEREAKKSAKKP--------- 416
+L E +E +R R G SS D + A REAK+ A +P
Sbjct: 120 ETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRA---REAKQPAPEPPKPYSLVRE 176
Query: 417 QSSSTEPARKPGQK-EKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKL 475
SSS P K +K +K+ R + + P R RK+S +KKK S E
Sbjct: 177 SSSSRSPTPKQKKKKKKKDRGRRSESSSP---RRERKKSS--------KKKKHRSESESK 225
Query: 476 QKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDV 535
++ H K S D KR K + K RR +
Sbjct: 226 KRKHRSPTPKSKRKSKDKKR-------------------KRSRSTTPAPKSRRAHRSTSA 266
Query: 536 MEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPS 595
++ +R +SR K AG A + GE A P + +PS
Sbjct: 267 DSASSSDTSRSRSRSAAAKTHTTA---LAGRSPSPASGR-RGEGDAPFSEPGTTSTQRPS 322
Query: 596 TDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGP 629
+ + AT Q EDK+ ++ S P
Sbjct: 323 SPET------ATKQPSSPYEDKDKDKKEKSATRP 350
Score = 29.6 bits (65), Expect = 9.4
Identities = 39/182 (21%), Positives = 60/182 (32%), Gaps = 25/182 (13%)
Query: 139 RMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSS---- 194
R S S + + R +P + R + ++ SP S S +
Sbjct: 1967 RRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAI 2026
Query: 195 ESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSA 254
S P K R+ R PL R++ ++ + + K + P RSA
Sbjct: 2027 RRRSRSRTPLLPRK----RSRSRSPLAIRRRSRSRTPRTARGKRSL--TRSPPAIRRRSA 2080
Query: 255 SSSSSSSSSSDSDVSVKKPPRGR---------------KPAEKPLPKPRGRKPKPERPPS 299
S SSS S S + + + R +P+ P P R R P P
Sbjct: 2081 SGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLG 2140
Query: 300 SS 301
SS
Sbjct: 2141 SS 2142
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 83.6 bits (205), Expect = 6e-16
Identities = 118/554 (21%), Positives = 215/554 (38%), Gaps = 79/554 (14%)
Query: 163 KMSVSKRARKAS----SDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRG 218
K+ V +++ K + ++ V+ E E ++ E+ +++ E++A
Sbjct: 443 KIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE------- 495
Query: 219 PLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRK 278
GG ++ K+P A ++ S + + P A + S + S VK P + +
Sbjct: 496 --GGEEETKSPPAEEAASP-EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKS 552
Query: 279 PAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRI---SEWKRRDEARRREL-------E 328
PA++ P K PE+ + S ++ S E + E K EA+ E E
Sbjct: 553 PAKEEAKSPPEAK-SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE 611
Query: 329 ARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKG 388
A+ E + ++ + E K + ++ E + + E E P K +
Sbjct: 612 AKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVK 671
Query: 389 RGRGPPSSSDSEPEAELE---------REAKKSAKKPQSSSTEPARKPGQKEKRVRPEEK 439
P + S +AE + +E KS +K +S E A+ P + + V+ E K
Sbjct: 672 AEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 731
Query: 440 QQAK---PVK-----VERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSP 491
K PVK E+ + + ++D K + K P+ EE KF K SP
Sbjct: 732 TPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD---KFPEKAKSP 788
Query: 492 DVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVL 551
EE+ + + L+++ KA + + K EV + +K
Sbjct: 789 -------VKEEVKSPEKAKSPLKEDA------------KAPEKEIPKKEEVKSPVKEEEK 829
Query: 552 GPKIEAVQKVNKAGMEK----EKAEEKLAG--EELAGEEAPQEKAEDKPSTDLSAPVNGE 605
+++ + KA EK K EEK EE +EAP+ K E+K + P +
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889
Query: 606 ATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLH-----DSVREGPD---LDRPGSDRQER 657
++K E AEDK+ + E + ED + ++ PD P +++
Sbjct: 890 VEAKK-EEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948
Query: 658 ERARGDSEALDEES 671
E A + +E++
Sbjct: 949 EAAPEKKDTKEEKA 962
Score = 78.6 bits (192), Expect = 2e-14
Identities = 83/423 (19%), Positives = 160/423 (37%), Gaps = 36/423 (8%)
Query: 87 NPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDS 146
+P + S + S +EA + E + T A + + +
Sbjct: 600 SPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEE 659
Query: 147 DKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTP 206
KS + + K A +K KA + + + SP +EE ++ +P
Sbjct: 660 AKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719
Query: 207 EK-----KAAVRAPRRGPLGGRKKKKAPSASDSDSKAD-----SDGAKPEPVAMARSASS 256
EK K + P + +++ K+P + S KA S AK ARS +
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779
Query: 257 SSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEW 316
+ S VK P + + P ++ P PK E S + EV
Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPP 839
Query: 317 KRRDEAR-------RRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGS 369
K+ +E + + ++++ ++E + + +EK+E + + + EA++
Sbjct: 840 KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED 899
Query: 370 SGD------------ELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQ 417
E++ED +P +K + + P + EP E+ K++A + +
Sbjct: 900 KKKVPTPEKEAPAKVEVKEDAKPKEKT--EVAKKEPDDAKAKEPSKPAEK--KEAAPEKK 955
Query: 418 SSSTEPARKPGQKEK---RVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEK 474
+ E A+KP +K K + + ++K +K + K + S D+K K E + E+K
Sbjct: 956 DTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015
Query: 475 LQK 477
K
Sbjct: 1016 AAK 1018
Score = 76.6 bits (187), Expect = 7e-14
Identities = 111/551 (20%), Positives = 206/551 (37%), Gaps = 66/551 (11%)
Query: 79 EGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASD 138
EG E +P A +A P + EA + + E +E + V + +
Sbjct: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 139 RMESDSDSDKSSDN-----------SGLKRKTPALKMSVS----KRARKASSDLDQASVS 183
+ E+ S + S S K K+PA + + S K KA S + + + S
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
Query: 184 PSEEEN---SESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
P+E ++ E+ S +E S + K ++P + +++ K+P + S KA++
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPK------- 293
PE A + S + S K P + + P ++ P K
Sbjct: 675 KS--PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT 732
Query: 294 PERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERR 353
PE+ S ++ S E + E + + + E + + E + E+ K +
Sbjct: 733 PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
Query: 354 RERADRGEAERGSGGSSGDELREDDE-PVKKRGRKGRGRGPPSSSDSEPEAELEREAKKS 412
+ ++ ++ L+ED + P K+ +K + P + E +++ KK+
Sbjct: 793 VKSPEKAKSP----------LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA 842
Query: 413 A--KKPQSSSTEPARKPGQKE--KRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKE 468
K P + TE + ++E K+ P+ K + K K S+ + + E KK+
Sbjct: 843 EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKK 902
Query: 469 PSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRR 528
EK E+K K P K +++ +K D + +
Sbjct: 903 VPTPEKEAPAKVEVKEDAK---PKEK---------------TEVAKKEPDDAKAKEPSKP 944
Query: 529 YKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKE----KAE--EKLAGEELAG 582
+ + EK + K PK EA K + + KE KAE EK + +
Sbjct: 945 AEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKD 1004
Query: 583 EEAPQEKAEDK 593
+ P++ EDK
Sbjct: 1005 SKPPEKATEDK 1015
Score = 70.1 bits (170), Expect = 6e-12
Identities = 77/401 (19%), Positives = 156/401 (38%), Gaps = 21/401 (5%)
Query: 63 KCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDED 122
K +K P K + + E +P + P + S +A +P + +
Sbjct: 633 KSPEKAKSPTKEEAKSP---EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK 689
Query: 123 RGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASV 182
A + V A S E K S K K+P + + K KA S + + +
Sbjct: 690 SPEKAKSPVKEEAKSP--EKAKSPVKEEAKSPEKAKSPVKEEA--KTPEKAKSPVKEEAK 745
Query: 183 SPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRK--KKKAPSASDSDSKADS 240
SP + ++ E + + S + TP K+ A + P + K++ S + S
Sbjct: 746 SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKE 805
Query: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSS 300
D PE + S +V VK+PP+ + + P PK E S
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPAT------PKTEEKKDS 859
Query: 301 SSSDSDSDEVDR--ISEWKRRDEARRRELEARRRREQEEELRRLREQEKE---EKERRRE 355
++ E + + E K + +E + ++E+ E+ +++ EKE + E + +
Sbjct: 860 KKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED 919
Query: 356 RADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKK 415
+ + E + +E +P +K+ + +PE + + EAK + +
Sbjct: 920 AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK-AKED 978
Query: 416 PQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEG 456
++ S EP++ +K ++ +++ +KP + K ++G
Sbjct: 979 DKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019
Score = 63.5 bits (153), Expect = 6e-10
Identities = 89/395 (22%), Positives = 149/395 (37%), Gaps = 34/395 (8%)
Query: 283 PLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRL 342
P P G P+ P S+ S+E ++ E + E E EQ EE +
Sbjct: 419 PFSLPEGL---PKIPSVSTHIKVKSEEKIKVVE--------KSEKETVIVEEQTEETQVT 467
Query: 343 RE-QEKEEKERRRERA---DRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSD 398
E E+EEKE + E + GE E GG E P ++ + P +
Sbjct: 468 EEVTEEEEKEAKEEEGKEEEGGEEEEAEGG----EEETKSPPAEEAASPEKEAKSPVKEE 523
Query: 399 SEPEAELEREAKKSAKKP-QSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGF 457
++ AE + K+ AK P + S E A+ P ++E + PE K K +S
Sbjct: 524 AKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEK 583
Query: 458 SMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNT 517
+ E+ K P+ + +K S +K K SP + E +V S K+
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKEEAK--SPAEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 518 DVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAG 577
+ K+ + + + +K+ P+ +A V EKA+ +
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE-KAKSPVKAEAKSPEKAKSPVKE 700
Query: 578 EELAGEEAPQE-KAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSED 636
E + E+A K E K +PV EA + E A+ EE + E+ ++
Sbjct: 701 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP--EKAKSPVKEEAKSPEKAKSPEKAKT 758
Query: 637 LHDSVREGPDLDRPGSDRQERERARGDSEALDEES 671
L D+ P + +E AR ++ E++
Sbjct: 759 L--------DVKSPEAKTPAKEEARSPADKFPEKA 785
Score = 39.3 bits (90), Expect = 0.012
Identities = 83/408 (20%), Positives = 153/408 (37%), Gaps = 83/408 (20%)
Query: 302 SSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRR--LREQEKEEKERRRERADR 359
++D+ + I+E++R+ +AR ELEA + + E +R L ++ + + +E +
Sbjct: 307 NTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQ 366
Query: 360 GEAE-RGSGGSSGDELREDDEPVKKR---------------GRKGR-GRGP--------- 393
+AE R + +LRE + + + G + R G GP
Sbjct: 367 LDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGL 426
Query: 394 ---PSSS---------------DSEPEAELERE--------------AKKSAK----KPQ 417
PS S SE E + E +K AK K +
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEE 486
Query: 418 SSSTEPARKPGQKEKRVRP------EEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSV 471
E + G++E + P EK+ PVK E + +E S ++ E+ K P+
Sbjct: 487 EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK-EEAKSPAEAKSPEK--EEAKSPAE 543
Query: 472 EEKLQKLHS----EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIR 527
+ +K S E K + SP+ + + E + S ++ +
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEK 603
Query: 528 RYKANKDVMEKAAEVYTRLKSRVLGP-KIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAP 586
K+ + AE + +K P ++++ +K E+ K+ EK E ++P
Sbjct: 604 AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSP 663
Query: 587 QE-----KAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGP 629
++ KAE K +PV EA S + + KE + + + P
Sbjct: 664 EKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Score = 36.2 bits (82), Expect = 0.10
Identities = 37/216 (17%), Positives = 85/216 (39%), Gaps = 14/216 (6%)
Query: 148 KSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPE 207
K S +K + ++ V + +KA + A+ E+++S+ +K + + E
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Query: 208 KKA-AVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDS 266
KK AV P+ + +K++ A+ P P A + + +
Sbjct: 877 KKEPAVEKPKESKVEAKKEE-----------AEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 267 DVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRE 326
KK P K A++P ++ PE+ + +E + + D+ +
Sbjct: 926 TEVAKKEPDDAK-AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSK 984
Query: 327 LEARRRREQEEELRRLREQEKEEKERRRE-RADRGE 361
++ + E+ E+ +++ + E+ E +A +G+
Sbjct: 985 EPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 82.8 bits (203), Expect = 9e-16
Identities = 84/330 (25%), Positives = 138/330 (41%), Gaps = 40/330 (12%)
Query: 221 GGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPA 280
GGR + S S S SK+ S R S S S S + S +K R K
Sbjct: 305 GGRSRSHTRSKSRSSSKSHS----------RRKRSQSKHRSRSHNRSRSRQKDRRRSKSP 354
Query: 281 EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELR 340
K K R R+ R S +++ K +D + RE E R +E+E
Sbjct: 355 HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 414
Query: 341 RLREQEKE-------EKERRRERADRGEAERG---SGGSSGDELREDD---EPVKKRGRK 387
+ R++E+E EK+R RER E +R ++ RE D E +KR +
Sbjct: 415 KDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD 474
Query: 388 GRGRGPPSS------SDSEPEAELEREAKKSAKKPQSSST---EPARKPGQKEKRVRPEE 438
+ R PP S S S R ++ S++ P++S T + +R P + + + ++
Sbjct: 475 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK 534
Query: 439 KQQAKP-VKVERTRKRSEGF---SMDRKVEKKKE---PSVEEKLQKLHSEIKFALKVDSP 491
+++ + + R R+RS S DR ++K E S++EK + + +VD
Sbjct: 535 REKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594
Query: 492 DVKRC-LNALEELGTLQVTSQILQKNTDVV 520
D R N ++ G Q+ + L T+ V
Sbjct: 595 DAPRTEENKIQHNGNCQLNEENLSTKTEAV 624
Score = 42.0 bits (97), Expect = 0.002
Identities = 67/320 (20%), Positives = 119/320 (37%), Gaps = 18/320 (5%)
Query: 321 EARRRELEA--RRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDD 378
+A +ELE +R RE + + E E + R+ R S SS R
Sbjct: 269 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 328
Query: 379 EPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEE 438
K R R R D ++ KS ++ +S S +R +K+ R + +E
Sbjct: 329 SQSKHRSRS-HNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDK-RKDTREKIKE 386
Query: 439 KQQAKPVKVERTRKRSE--------GFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDS 490
K++ K E+ R+R + G + DR E++K+ +++ + K K D
Sbjct: 387 KERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEK-DR 445
Query: 491 PDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAE-VYTRLKSR 549
K E+ + +I +K + R Y A++ + E R +S
Sbjct: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505
Query: 550 VLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQ 609
P+ K + ++ K + + E+ E + ST + N +
Sbjct: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKE 565
Query: 610 KGE----SAEDKEHEEGRDS 625
K E S ++KEH + DS
Sbjct: 566 KLEKNSTSLKEKEHNKEPDS 585
Score = 42.0 bits (97), Expect = 0.002
Identities = 54/283 (19%), Positives = 111/283 (39%), Gaps = 37/283 (13%)
Query: 377 DDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRP 436
+ E K RKG + S S ++ K+S K +S S +R + +R +
Sbjct: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353
Query: 437 EEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRC 496
K+++K ER + RS S D++ + +++ +E++++ E + + + K
Sbjct: 354 PHKKRSK--SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEK-- 409
Query: 497 LNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIE 556
E G KN D +K R KD + + + + + +
Sbjct: 410 -----ERG----------KNKDRDKEREKDREKDKEKDREREREKEHEKDRDK------- 447
Query: 557 AVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAED 616
+K + EKE+ +++ +E +++ +DK S + P + A+ + S+ +
Sbjct: 448 --EKEKEQDKEKEREKDR-------SKEIDEKRKKDKKSR--TPPRSYNASRRSRSSSRE 496
Query: 617 KEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERER 659
+ R S PR + S P ++E+ER
Sbjct: 497 RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 539
Score = 39.7 bits (91), Expect = 0.009
Identities = 45/226 (19%), Positives = 79/226 (34%), Gaps = 21/226 (9%)
Query: 141 ESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTS 200
E D + ++ + K K K K + E+ E + EK
Sbjct: 392 EKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEK 451
Query: 201 DQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSS 260
+QD E++ R + ++KK S + S S ++ R S SSS
Sbjct: 452 EQDKEKEREK----DRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 507
Query: 261 SSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRD 320
S + + RK + P P+ R +K K + + D + E +R
Sbjct: 508 SPRTSKTIK-------RKSSRSPSPRSRNKKDK--------KREKERDHISERRERERST 552
Query: 321 EARRRELEARRRREQEEELRRLREQE--KEEKERRRERADRGEAER 364
R+ + + + E+ L+E+E KE + D +A R
Sbjct: 553 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 598
Score = 32.7 bits (73), Expect = 1.1
Identities = 26/139 (18%), Positives = 58/139 (41%), Gaps = 1/139 (0%)
Query: 527 RRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELA-GEEA 585
++ +++ + + ++R K + KI+ ++V + EKE+ EK +E G+
Sbjct: 356 KKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415
Query: 586 PQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGP 645
++K +K ++ E DKE E+ +D E+ S+++ + ++
Sbjct: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK 475
Query: 646 DLDRPGSDRQERERARGDS 664
P R+R S
Sbjct: 476 KSRTPPRSYNASRRSRSSS 494
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 82.8 bits (203), Expect = 9e-16
Identities = 84/330 (25%), Positives = 138/330 (41%), Gaps = 40/330 (12%)
Query: 221 GGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPA 280
GGR + S S S SK+ S R S S S S + S +K R K
Sbjct: 189 GGRSRSHTRSKSRSSSKSHS----------RRKRSQSKHRSRSHNRSRSRQKDRRRSKSP 238
Query: 281 EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELR 340
K K R R+ R S +++ K +D + RE E R +E+E
Sbjct: 239 HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 298
Query: 341 RLREQEKE-------EKERRRERADRGEAERG---SGGSSGDELREDD---EPVKKRGRK 387
+ R++E+E EK+R RER E +R ++ RE D E +KR +
Sbjct: 299 KDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD 358
Query: 388 GRGRGPPSS------SDSEPEAELEREAKKSAKKPQSSST---EPARKPGQKEKRVRPEE 438
+ R PP S S S R ++ S++ P++S T + +R P + + + ++
Sbjct: 359 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK 418
Query: 439 KQQAKP-VKVERTRKRSEGF---SMDRKVEKKKE---PSVEEKLQKLHSEIKFALKVDSP 491
+++ + + R R+RS S DR ++K E S++EK + + +VD
Sbjct: 419 REKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 478
Query: 492 DVKRC-LNALEELGTLQVTSQILQKNTDVV 520
D R N ++ G Q+ + L T+ V
Sbjct: 479 DAPRTEENKIQHNGNCQLNEENLSTKTEAV 508
Score = 42.0 bits (97), Expect = 0.002
Identities = 67/320 (20%), Positives = 119/320 (37%), Gaps = 18/320 (5%)
Query: 321 EARRRELEA--RRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDD 378
+A +ELE +R RE + + E E + R+ R S SS R
Sbjct: 153 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 212
Query: 379 EPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEE 438
K R R R D ++ KS ++ +S S +R +K+ R + +E
Sbjct: 213 SQSKHRSRS-HNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDK-RKDTREKIKE 270
Query: 439 KQQAKPVKVERTRKRSE--------GFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDS 490
K++ K E+ R+R + G + DR E++K+ +++ + K K D
Sbjct: 271 KERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEK-DR 329
Query: 491 PDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAE-VYTRLKSR 549
K E+ + +I +K + R Y A++ + E R +S
Sbjct: 330 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 389
Query: 550 VLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQ 609
P+ K + ++ K + + E+ E + ST + N +
Sbjct: 390 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKE 449
Query: 610 KGE----SAEDKEHEEGRDS 625
K E S ++KEH + DS
Sbjct: 450 KLEKNSTSLKEKEHNKEPDS 469
Score = 42.0 bits (97), Expect = 0.002
Identities = 54/283 (19%), Positives = 111/283 (39%), Gaps = 37/283 (13%)
Query: 377 DDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRP 436
+ E K RKG + S S ++ K+S K +S S +R + +R +
Sbjct: 178 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 237
Query: 437 EEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRC 496
K+++K ER + RS S D++ + +++ +E++++ E + + + K
Sbjct: 238 PHKKRSK--SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEK-- 293
Query: 497 LNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIE 556
E G KN D +K R KD + + + + + +
Sbjct: 294 -----ERG----------KNKDRDKEREKDREKDKEKDREREREKEHEKDRDK------- 331
Query: 557 AVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAED 616
+K + EKE+ +++ +E +++ +DK S + P + A+ + S+ +
Sbjct: 332 --EKEKEQDKEKEREKDR-------SKEIDEKRKKDKKSR--TPPRSYNASRRSRSSSRE 380
Query: 617 KEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERER 659
+ R S PR + S P ++E+ER
Sbjct: 381 RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 423
Score = 39.7 bits (91), Expect = 0.009
Identities = 45/226 (19%), Positives = 79/226 (34%), Gaps = 21/226 (9%)
Query: 141 ESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTS 200
E D + ++ + K K K K + E+ E + EK
Sbjct: 276 EKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEK 335
Query: 201 DQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSS 260
+QD E++ R + ++KK S + S S ++ R S SSS
Sbjct: 336 EQDKEKEREK----DRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 391
Query: 261 SSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRD 320
S + + RK + P P+ R +K K + + D + E +R
Sbjct: 392 SPRTSKTIK-------RKSSRSPSPRSRNKKDK--------KREKERDHISERRERERST 436
Query: 321 EARRRELEARRRREQEEELRRLREQE--KEEKERRRERADRGEAER 364
R+ + + + E+ L+E+E KE + D +A R
Sbjct: 437 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 482
Score = 32.7 bits (73), Expect = 1.1
Identities = 26/139 (18%), Positives = 58/139 (41%), Gaps = 1/139 (0%)
Query: 527 RRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELA-GEEA 585
++ +++ + + ++R K + KI+ ++V + EKE+ EK +E G+
Sbjct: 240 KKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 299
Query: 586 PQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGP 645
++K +K ++ E DKE E+ +D E+ S+++ + ++
Sbjct: 300 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK 359
Query: 646 DLDRPGSDRQERERARGDS 664
P R+R S
Sbjct: 360 KSRTPPRSYNASRRSRSSS 378
>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
Length = 1441
Score = 82.4 bits (202), Expect = 1e-15
Identities = 89/359 (24%), Positives = 142/359 (39%), Gaps = 50/359 (13%)
Query: 136 ASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSE 195
+ D+ E DS KS N L+R++ + +S R + +D+A +E +
Sbjct: 990 SEDQEEKKKDSKKSKANL-LERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGR 1048
Query: 196 SEKTSD---------QDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD------- 239
+ S E++ + P+R RKK++ + DSDS D
Sbjct: 1049 GKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDE 1108
Query: 240 ---SDGAKPEPVAMARSASSSSSSS-SSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE 295
SDG++ E V + S S+ DSD R P+ R R+ P+
Sbjct: 1109 FKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPK 1168
Query: 296 RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEE-----K 350
+ S + +S+E R SE D+ +E RRRR + + R++ +E E K
Sbjct: 1169 KKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQK 1228
Query: 351 ERRRERADRGEAERGSGGSSGDEL-----REDDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
RR + R +R S +E EDDE K+ R R RG + SE + E
Sbjct: 1229 SLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEE 1288
Query: 406 EREAKKSAKK---------------PQSSSTEPARKPGQKEKRVRPEEKQQA-KPVKVE 448
E E K ++K + +PAR + RV P E++ KP ++E
Sbjct: 1289 EEEEGKPSRKRLHRIETDEEESCDNAHGDANQPAR---DSQPRVLPSEQESTKKPYRIE 1344
Score = 52.0 bits (123), Expect = 2e-06
Identities = 81/384 (21%), Positives = 139/384 (36%), Gaps = 60/384 (15%)
Query: 98 VSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKR 157
+ S ++ E +P + E D MA + TA S ++ S + +
Sbjct: 522 IHSQKAQIEEPDPPEM----ETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDK 577
Query: 158 KTPALK-MSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFT----------- 205
+ P L+ + ++++K D D +SP EE +S+ ESEK +
Sbjct: 578 RPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDH 637
Query: 206 ----PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASS----- 256
+K V +GG+ KK + K DS+ K E + + +S
Sbjct: 638 CEKLASEKEVVECQSTSTVGGQSVKKVDLET---LKEDSEFTKVEMDNLDNAQTSGIEEP 694
Query: 257 SSSSSSSSDSDVSVKKPP--------------RGRKPAEKPLPKPRGRKPKPERPPSSSS 302
S + S S K P +K K + RK KP+ PP
Sbjct: 695 SETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLE 754
Query: 303 SDSDSDEVDRISEWKRRDEARRRELEARR--------RREQEEELRRLREQEKEEKERRR 354
++ ++ ++ E RR R R ++ ++ R E E EE+
Sbjct: 755 PENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTAL 814
Query: 355 ERADRGEAERGSGGSSGDELREDDEPVKKR--GRKGRGRGPPSSSD--------SEPEAE 404
++ D+ E + S + ++ + K R G + RGR SS+D A
Sbjct: 815 QKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAAS 874
Query: 405 LEREAKKSAKKPQSSSTEPARKPG 428
E E K+S + + EP +K G
Sbjct: 875 EEEEEKESEEAILADDDEPCKKCG 898
Score = 43.5 bits (101), Expect = 6e-04
Identities = 96/479 (20%), Positives = 173/479 (36%), Gaps = 99/479 (20%)
Query: 185 SEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD----- 239
++EE+ S + ++ + T + + + + G L +K+ AP D+DS
Sbjct: 467 TKEESYSPSKDRNIITEGNGTESLNSVITSMKTGEL---EKETAPLRKDADSSISVLEIH 523
Query: 240 ---SDGAKPEPVAMARSASSS-------SSSSSSSDSDVSVK---KPPRGRKPAEKPL-- 284
+ +P+P M S SS S ++ SS ++K K P+ +K P+
Sbjct: 524 SQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILE 583
Query: 285 ---------------------------PKPRGRKPKPERPPSSSSSDSDS--DEVDRISE 315
PK KP P ++ +S + D ++++
Sbjct: 584 CLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLAS 643
Query: 316 WKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELR 375
K E + + ++ + E KE+ E + D + + SG
Sbjct: 644 EKEVVECQSTSTVGGQSVKKVD-----LETLKEDSEFTKVEMDNLDNAQTSG-------- 690
Query: 376 EDDEPVKKRGRKGRGRG-----PPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQK 430
+EP + +G + + P + + E+ E +K K + +KP
Sbjct: 691 -IEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSP 749
Query: 431 EKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDS 490
K + PE KQ E+T K E ++ R + ++ P + K+ +EI+
Sbjct: 750 PKVLEPENKQ-------EKTEKEEEKTNVGRTL--RRSPRISRPTAKV-AEIR------- 792
Query: 491 PDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRV 550
D K E ++ S LQK TD LK K+ KD K ++V + K R
Sbjct: 793 -DQKADKKRGEGEDEVEEESTALQK-TDKKEILK-----KSEKDTNSKVSKVKPKGKVRW 845
Query: 551 LGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKA----EDKPSTDLSAPVNGE 605
G + K + + EK + EE E+A +D+P P + E
Sbjct: 846 TGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPE 904
Score = 42.0 bits (97), Expect = 0.002
Identities = 76/352 (21%), Positives = 124/352 (35%), Gaps = 66/352 (18%)
Query: 101 SDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTP 160
SDS E D + +D V++ + DSD+D S R+ P
Sbjct: 1096 SDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRL---RRHP 1152
Query: 161 ALKMSVSKRARKASSDL---DQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRR 217
+ M S+R R+ + D SEE + +S S+ DF ++ R ++
Sbjct: 1153 SRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQK 1212
Query: 218 GPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSS---SSSSDSDVSVKKPP 274
+ K S SD K+ G + V R +SS S S +S+ D K+
Sbjct: 1213 RQI----NYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESK 1268
Query: 275 RGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRRE 334
R + RGR S+ S++DE E E +
Sbjct: 1269 RS--------VRKRGR---------STDEYSEADE----------------EEEEEEGKP 1295
Query: 335 QEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPP 394
+ L R+ E+E + G+A + + S L + E KK P
Sbjct: 1296 SRKRLHRIETDEEESCDNA-----HGDANQPARDSQPRVLPSEQESTKK----------P 1340
Query: 395 SSSDSEPEAELEREAKKSAKKPQSSSTEPA---RKPGQKEKRV--RPEEKQQ 441
+S+ E + E K + S P+ + PG+ + + +P EK Q
Sbjct: 1341 YRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQ 1392
Score = 37.0 bits (84), Expect = 0.059
Identities = 51/253 (20%), Positives = 104/253 (41%), Gaps = 42/253 (16%)
Query: 395 SSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKE-------------KRVRPEEKQQ 441
S S + E + E E K ++ +S + +P E K+ + +EK+
Sbjct: 227 SPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKEL 286
Query: 442 AK-PVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCL--- 497
K PV V+ + E + ++K+ K++ S +E ++ + E+K + D D K +
Sbjct: 287 VKLPVIVKLEKPLPE--NEEKKIIKEESDSFKENVKPIKVEVK-ECRADPKDTKSSMEKP 343
Query: 498 -----NALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLG 552
+E G ++ + +I +K+T+ LK ++ K + ++ ++ S V G
Sbjct: 344 VAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKI--PLKKREIKLSDDFDSPVKG 401
Query: 553 PKIEAVQKVNKAGMEKEKAEEKLA------------GEELAGEEAPQEKAEDKPSTDLSA 600
P ++V + ++ K EE+ G++L E E+ T+
Sbjct: 402 PLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTE--- 458
Query: 601 PVNGEATSQKGES 613
P+ + K ES
Sbjct: 459 PIETKFYETKEES 471
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 82.0 bits (201), Expect = 2e-15
Identities = 82/382 (21%), Positives = 147/382 (38%), Gaps = 45/382 (11%)
Query: 133 ATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSES 192
A+ + + D + + + S L R+ S+ KR +S + S S + E + +S
Sbjct: 409 ASPVQKKEKKDKERENEKEKSALARER-----SLKKRQSLPASPRARLSASTASELSPKS 463
Query: 193 SSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMAR 252
+ S T + A P GP G K PS + + + E +
Sbjct: 464 KARPSSPS----TSWHRPASPCPSPGP-GHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
Query: 253 SASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS------- 305
SA+ S S + K+ PA P P P P+ E+PP+ + +D+
Sbjct: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPP 578
Query: 306 ----------------DSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQE--K 347
D +E R+ KRR +RE E + RR Q E +R+RE++ +
Sbjct: 579 APAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAR 638
Query: 348 EEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELER 407
E + R A+ E +E+ E ++K+ + R + E E
Sbjct: 639 EAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHF 698
Query: 408 EAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAK--------PVKVERTRKRSEGFSM 459
+ ++ ++ + E K +K + ++KQ +K P V+ RS G +
Sbjct: 699 QQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPG--L 756
Query: 460 DRKVEKKKEPSVEEKLQKLHSE 481
++ +K+EP +E L S+
Sbjct: 757 QKEAVQKEEPIPQEPQWSLPSK 778
Score = 47.4 bits (111), Expect = 4e-05
Identities = 49/278 (17%), Positives = 108/278 (38%), Gaps = 34/278 (12%)
Query: 171 RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPS 230
RK + ++ P ++ S+ + +EK S +P A P +K++ P+
Sbjct: 510 RKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPP----QKEQPPA 565
Query: 231 ASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKK----PPRGRKPAEKPLPK 286
+ +D+ + P P + ++ + ++ K+ R R+ E+ L
Sbjct: 566 ETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQA 625
Query: 287 PRGRKPKPER--------------------PPSSSSSDSDSDEVDRISEWKR------RD 320
R ++ + E+ + + ++ +E +R+ + K R+
Sbjct: 626 ERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSRE 685
Query: 321 EARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEP 380
EA R+ LE + +Q+E+ R+ R + EE +R +++ E ++ + EP
Sbjct: 686 EAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEP 745
Query: 381 VKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQS 418
VK + G + EP + + + S + P S
Sbjct: 746 VKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPAS 783
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/136 (28%), Positives = 58/136 (42%), Gaps = 14/136 (10%)
Query: 226 KKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLP 285
K A S+ + +S + P R A S SS P G + A P
Sbjct: 56 KNATSSKQLPLEPESPSGQVGP----RPAPPQEESPSSEAKSRGPTPPAMGPRDARPPR- 110
Query: 286 KPRGRKPKPERPPSSSSSDSDSDEVDRISEW----KRRDEARRRELEARRR--REQEEEL 339
R +P P P+S S + EV + E K R E R + L A++ E+EE+
Sbjct: 111 --RSSQPSPTAVPASDSPPT-KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKA 167
Query: 340 RRLREQEKEEKERRRE 355
+ LRE++ +E+ RR E
Sbjct: 168 KALREKQLQERRRRLE 183
Score = 35.4 bits (80), Expect = 0.17
Identities = 52/236 (22%), Positives = 88/236 (37%), Gaps = 25/236 (10%)
Query: 262 SSSDSDVSVKKPPR--GRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRR 319
S +++ PP R P E P P P G P P S+ D+ D + K
Sbjct: 3 SGPRAELGAGAPPAVVARTPPE-PRPSPEGDPSPPPPPMSALVPDTPPDTPPAM---KNA 58
Query: 320 DEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEA--------ERGSGGSSG 371
+++ LE Q R QE+ + R A R S S
Sbjct: 59 TSSKQLPLEPESPSGQVGP-RPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSP 117
Query: 372 DELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKE 431
+ D P K+ K G + + E AKK+ + + R+ +E
Sbjct: 118 TAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQE 177
Query: 432 KRVRPEEK----QQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIK 483
+R R EE+ +Q + ER R++ E K +++ E +++ ++K +EI+
Sbjct: 178 RRRRLEEQRLKAEQRRAALEERQRQKLE------KNKERYEAAIQRSVKKTWAEIR 227
Score = 34.3 bits (77), Expect = 0.38
Identities = 36/160 (22%), Positives = 64/160 (40%), Gaps = 23/160 (14%)
Query: 206 PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSD 265
PE + PR P P S+A S G P P R A SS S
Sbjct: 68 PESPSGQVGPRPAP---------PQEESPSSEAKSRGPTP-PAMGPRDARPPRRSSQPSP 117
Query: 266 SDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEA--- 322
+ V P ++ +K + + K + E ++ + W ++E
Sbjct: 118 TAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKK--------AVWLEKEEKAKA 169
Query: 323 -RRRELEARRRREQEEELRRLREQEKEEKERRRERADRGE 361
R ++L+ RRRR +E+ L+ + + E ER+R++ ++ +
Sbjct: 170 LREKQLQERRRRLEEQRLKAEQRRAALE-ERQRQKLEKNK 208
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 80.9 bits (198), Expect = 4e-15
Identities = 57/188 (30%), Positives = 94/188 (50%), Gaps = 12/188 (6%)
Query: 290 RKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEE 349
++ K ER + ++ R E +R+ E ++E + R++E+ E +R RE+E +E
Sbjct: 49 KEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKE 108
Query: 350 KERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREA 409
E + +R + + ERG G E RE E K+ RK R R E E E ER+
Sbjct: 109 GEEKEKRKKKEKKERGRTSKEGKE-RERKEERKREERKERER-----KKEEREKERERKE 162
Query: 410 KKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEP 469
+K ++ Q E RK +KE++ R + ++ K K ER RK +RK E+KK+
Sbjct: 163 RKKRERKQVGEKEEERK--EKERKERKKRERNRKERKKERERKERR----ERKKERKKKE 216
Query: 470 SVEEKLQK 477
+++ QK
Sbjct: 217 ERKKERQK 224
Score = 80.1 bits (196), Expect = 6e-15
Identities = 51/168 (30%), Positives = 87/168 (51%), Gaps = 7/168 (4%)
Query: 317 KRRDEARRRELEARRRREQEEELRRLREQEKEEK--ERRRERADRGEAERGSGGSSGDEL 374
K R+ R++E R +R++E E R RE+ K+EK ER++E +R + R G
Sbjct: 53 KERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEG--- 109
Query: 375 REDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKS-AKKPQSSSTEPARKPGQKEKR 433
E+ E KK+ +K RGR + E + E +RE +K +K + E RK +K +R
Sbjct: 110 -EEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRER 168
Query: 434 VRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSE 481
+ EK++ + K + RK+ E +RK E++++ E K ++ E
Sbjct: 169 KQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKE 216
Score = 75.1 bits (183), Expect = 2e-13
Identities = 50/181 (27%), Positives = 87/181 (48%), Gaps = 12/181 (6%)
Query: 271 KKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEAR 330
+K RG+K EK + + + + +R + + + E + E K R + E
Sbjct: 77 RKRERGKK--EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERE 134
Query: 331 RRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRG 390
R+ E++ E R+ RE++KEE+E+ RER +R + ER G +E +E + +K+ + R
Sbjct: 135 RKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR- 193
Query: 391 RGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERT 450
E E + RE KK KK E +K QK+++ EK++ K + ER
Sbjct: 194 ----KERKKERERKERRERKKERKK-----KEERKKERQKDRQTNWREKERGKRERKERK 244
Query: 451 R 451
+
Sbjct: 245 K 245
Score = 54.3 bits (129), Expect = 4e-07
Identities = 38/184 (20%), Positives = 74/184 (40%), Gaps = 4/184 (2%)
Query: 186 EEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKP 245
+E SE E + + EK+ ++ G RKK++ K + +G +
Sbjct: 53 KERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEK 112
Query: 246 EPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS 305
E +S + + ++ RK E+ + + + ER
Sbjct: 113 EKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVG 172
Query: 306 DSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADR----GE 361
+ +E + E K R + R E ++ RE++E R +E++K+E+ ++ + DR E
Sbjct: 173 EKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWRE 232
Query: 362 AERG 365
ERG
Sbjct: 233 KERG 236
Score = 42.4 bits (98), Expect = 0.001
Identities = 55/258 (21%), Positives = 97/258 (37%), Gaps = 52/258 (20%)
Query: 402 EAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDR 461
E E E E +K KK + S + R+ +K KR R E+ RKR G
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKRER------------EKERKRERG----- 82
Query: 462 KVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVA 521
K EKK E EE+ +K K +N +
Sbjct: 83 KKEKKGERKKEERERKKRRREK-------------------------------ENKEGEE 111
Query: 522 TLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELA 581
K+ ++ K + K + R + R + E +K + E+E+ E K +
Sbjct: 112 KEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQV 171
Query: 582 GEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSV 641
GE+ + K +++ N + ++ E E +E ++ R +E + +D +
Sbjct: 172 GEKEEERKEKERKERK-KRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNW 230
Query: 642 REGPDLDRPGSDRQERER 659
RE +R +R+ER++
Sbjct: 231 RE---KERGKRERKERKK 245
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/171 (15%), Positives = 66/171 (38%)
Query: 186 EEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKP 245
E+E + EK ++ ++ R + G K+K+ + +G +
Sbjct: 74 EKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 246 EPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS 305
E + + + ++ R ++ ++ K RK K + +
Sbjct: 134 ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR 193
Query: 306 DSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRER 356
+ +R + +R + R++ E R++ Q++ RE+E+ ++ER+ +
Sbjct: 194 KERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Score = 41.2 bits (95), Expect = 0.003
Identities = 47/215 (21%), Positives = 97/215 (45%), Gaps = 15/215 (6%)
Query: 379 EPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEE 438
+P + G + R ++ E + ERE+++ ++ + + R+ +K +R + E+
Sbjct: 27 KPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK 86
Query: 439 KQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLN 498
K + K K ER RK+ +++ E+K++ +EK ++ + + + + KR
Sbjct: 87 KGERK--KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR--- 141
Query: 499 ALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAV 558
EE + + +K + +K R+ + K V EK E + K R K E
Sbjct: 142 --EERKERERKKEEREKERE-----RKERKKRERKQVGEKEEE--RKEKERKERKKRERN 192
Query: 559 QKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDK 593
+K K E+++ E+ E EE +E+ +D+
Sbjct: 193 RKERKKERERKERRER-KKERKKKEERKKERQKDR 226
Score = 33.1 bits (74), Expect = 0.85
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 21/136 (15%)
Query: 534 DVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDK 593
++ E+ E+ TR + + + E+ +K + EK K E + + G++ ++K E K
Sbjct: 37 EIREREREIETRKEGK---KERESERKKERREREKRKREREKERKRERGKK--EKKGERK 91
Query: 594 PSTDLSAPVNGEATSQKGESAEDKEHEE----GRDSEEGPRCGSSEDLHDSVREGPDLDR 649
E +++GE E ++ +E GR S+EG E +R
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE------------ER 139
Query: 650 PGSDRQERERARGDSE 665
+R+ERER + + E
Sbjct: 140 KREERKERERKKEERE 155
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 79.7 bits (195), Expect = 8e-15
Identities = 98/430 (22%), Positives = 174/430 (40%), Gaps = 43/430 (10%)
Query: 72 NKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAV 131
N+ +GL + + + P +++SDSE+ E + D+D + E+R
Sbjct: 51 NETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQ--KDSDSESEERA------- 101
Query: 132 TATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASV-----SPSE 186
ASD D + S S RK P + +SD + V S SE
Sbjct: 102 -EPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSE 160
Query: 187 EENSESSSESEKTSDQDFTPE-KKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD------ 239
E + S S+ ++ P+ + P R + ++ P SDS+++
Sbjct: 161 IEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQ 220
Query: 240 -SDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKP--AEKPLPKPRGRKPKPER 296
SD EP S S + SD + PPR + + LPKPR + E
Sbjct: 221 VSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESED 280
Query: 297 PPSSSSSDSDSDEV------DRISEWKRRDEARRRELE--ARRRREQEEELRRLREQEKE 348
PP + +SDS+++E+ D SE ++ A E E +R +++ E + RE + E
Sbjct: 281 PPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGE 340
Query: 349 EKERRRER-ADRGEAERGSGGSSGDELRE------DDEPVKKRGRKGRGRGPPSSSDSEP 401
+ E + + +R SS E E D + +K G + + ++ S+
Sbjct: 341 DTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDS 400
Query: 402 EAELEREAKKS---AKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFS 458
E E + AKKS + S S + K G++EK + + +++A ++ + + F
Sbjct: 401 EDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFG 460
Query: 459 MDRKVEKKKE 468
D + ++E
Sbjct: 461 SDSESGNEEE 470
Score = 33.9 bits (76), Expect = 0.50
Identities = 57/299 (19%), Positives = 109/299 (36%), Gaps = 33/299 (11%)
Query: 395 SSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRS 454
S SD E + + + + S E + + K + + +P+ + + S
Sbjct: 25 SGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSES 84
Query: 455 EGFSMDRKVEKKKEPSVEEKLQKLHSEI--KFALKVDSPDVKRCLNALEELGTLQVTSQI 512
E + + + E E +E + +S + ++ + E L
Sbjct: 85 EELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHAS 144
Query: 513 LQKNTDVV------ATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVN---- 562
+N DV + ++++++ A+ E A + P+ +A N
Sbjct: 145 DSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPP 204
Query: 563 KAGMEKEKAEE--KLAGEELAGEEAPQEKAEDKPSTDLSAP--VNGEATSQKGESAEDKE 618
K M ++EE K + EE P+ +A D + +L P + E+ A D E
Sbjct: 205 KPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSE 264
Query: 619 HEE-------GRDSEEGPRCGSSED---------LHDSVREGPDLDRPGSDRQERERAR 661
+EE +SE+ PR +S+ + DS EGP P SD + + +R
Sbjct: 265 NEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ-KGPASDSETEDASR 322
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 79.3 bits (194), Expect = 1e-14
Identities = 99/490 (20%), Positives = 193/490 (39%), Gaps = 73/490 (14%)
Query: 197 EKTSDQDFTPEKKAAVRAPRRGPLGG-------------------RKKKKAPSASDSDSK 237
E T DF+ + + +PRR LG R+++K + ++D K
Sbjct: 19 EVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRK 78
Query: 238 ADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERP 297
+ K R + ++ + K + + R + + ER
Sbjct: 79 RERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERG 138
Query: 298 PSSSSSDSDSDEVDRISEWKRR---DEARRRELEARRRREQEEELRRLREQEKEEKERRR 354
+ E R +E +R D R+R+ E R++E+E E R QE+ E+ER+R
Sbjct: 139 RDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNR---QERRERERQR 195
Query: 355 ERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAK 414
E+ ++ E G + RE + +++ + R R + + + ERE +K A+
Sbjct: 196 EKENKTEDRHSERGRERERERETETETERKRQTDRER--------DRQRKTEREREKQAE 247
Query: 415 KPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERT-RKRSEGFSMDRKVEKKKEPSVEE 473
+ ++S E R ++ +R R ++ + + + +T RKR DR+ E+K+E E
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRER 307
Query: 474 KLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANK 533
+ + R N E + + Q+ T+ ++ R+ K
Sbjct: 308 ERE------------------RERNRKRERERERERERERQRETERDREKERERKRKRQT 349
Query: 534 DVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDK 593
++ R ++R G + + E+E+ E+ + A E +E+ D+
Sbjct: 350 EM--------DRERNRQTG-------REGRRQAERERERERERDRQSAREREERERDRDR 394
Query: 594 PSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRP-GS 652
+ + E+ + +E E+ R+SE G G + ++G + DR +
Sbjct: 395 DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRERE----KQKGRERDRERQT 450
Query: 653 DRQE-RERAR 661
DRQ R+R R
Sbjct: 451 DRQAGRQRKR 460
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/351 (22%), Positives = 155/351 (44%), Gaps = 32/351 (9%)
Query: 141 ESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLD-QASVSPSEEENSESSSESEKT 199
E + D+ +D +R+ + + +R R+ + Q + +E E + + +
Sbjct: 134 EGERGRDRQTDG---QRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRE 190
Query: 200 SDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSS 259
++ E K R RG ++++ + ++++ K +D + R +
Sbjct: 191 RERQREKENKTEDRHSERGR---ERERERETETETERKRQTDRERDRQRKTEREREKQAE 247
Query: 260 SSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKR- 318
+S+ + K + E+ + R R+ K ER + E DR +E KR
Sbjct: 248 RERASERETERDK----ERERERDRDRDRDRRQK-ERERQTDRKRQRRTERDRETERKRE 302
Query: 319 RDEARRRELEARRRREQEEELRRLREQEKE-------EKERRRERADRGEAERGSGGSSG 371
R R RE E R+RE+E E R RE+++E E+ER+R+R + E +R +G
Sbjct: 303 RQRERERERERNRKRERERERERERERQRETERDREKERERKRKR--QTEMDRERNRQTG 360
Query: 372 DELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKE 431
E R E ++R R+ R S+ + E E ER+ + +K + TE R GQ+E
Sbjct: 361 REGRRQAERERERERE---RDRQSARERE---ERERDRDRDRQKERERQTEKDR-DGQRE 413
Query: 432 ---KRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLH 479
+R R ++++ + + R R++ +G DR+ + ++ + K L+
Sbjct: 414 TEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLY 464
Score = 72.8 bits (177), Expect = 1e-12
Identities = 69/340 (20%), Positives = 138/340 (40%), Gaps = 6/340 (1%)
Query: 141 ESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENS-ESSSESEKT 199
E + +D+ D K + K + R+ D+ + E E ++ E E+
Sbjct: 104 ERERQTDRERDRQREKERNRQ-KERERETEREGERGRDRQTDGQRERERQRDAEKERERQ 162
Query: 200 SDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSS 259
+D++ + + + R +++++ + ++K + D R + +
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTE-DRHSERGRERERERETETE 221
Query: 260 SSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRR 319
+ +D + + + EK + R + + ER + DR + + R
Sbjct: 222 TERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERER 281
Query: 320 DEARRRELEARRRREQEEELRRLREQEKE-EKERRRERADRGEAER-GSGGSSGDELRED 377
R+R+ R RE E + R RE+E+E E+ R+RER E ER + D +E
Sbjct: 282 QTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKER 341
Query: 378 DEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPE 437
+ K++ R R + + +AE ERE ++ + QS+ R+ + R +
Sbjct: 342 ERKRKRQTEMDRERNRQTGREGRRQAERERERERERDR-QSAREREERERDRDRDRQKER 400
Query: 438 EKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQK 477
E+Q K +R ++ DR+ E+ +E E + QK
Sbjct: 401 ERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQK 440
Score = 72.0 bits (175), Expect = 2e-12
Identities = 76/363 (20%), Positives = 145/363 (39%), Gaps = 31/363 (8%)
Query: 115 DADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKAS 174
DAD DD +R +R +++ +D KR+ K KR R
Sbjct: 48 DADGDDRERN--------RQKERERRREKRQTERETDR---KRERRREKDRHRKRDRHRE 96
Query: 175 SDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDS 234
D+ +E ++ E ++ +++ +K+ R G G ++ +
Sbjct: 97 RQRDR-----EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERER 151
Query: 235 DSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKP-PRGRKPAEKPLPKPRGRKPK 293
A+ + + R + + + ++ R R+ K + R +
Sbjct: 152 QRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRE 211
Query: 294 PERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERR 353
ER + + + DR + +R+ E R RE +A R R E E R +E+E+E ++R
Sbjct: 212 RERERETETETERKRQTDRERDRQRKTE-REREKQAERERASERETERDKERERE-RDRD 269
Query: 354 RERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSA 413
R+R DR + ER R+ D K++ R R R + + E E ERE +
Sbjct: 270 RDR-DRRQKERE---------RQTDR--KRQRRTERDRETERKRERQRERERERERNRKR 317
Query: 414 KKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEE 473
++ + E R+ + R + E+++ + +++R R R G R+ E+++E E
Sbjct: 318 ERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERER 377
Query: 474 KLQ 476
Q
Sbjct: 378 DRQ 380
Score = 52.0 bits (123), Expect = 2e-06
Identities = 56/289 (19%), Positives = 115/289 (39%), Gaps = 18/289 (6%)
Query: 141 ESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENS---ESSSESE 197
E ++ ++ G +R+ + ++R R+ + D+ + E E E +SE E
Sbjct: 196 EKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERE 255
Query: 198 KTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSS 257
D++ E+ RR +K+++ + + + D R
Sbjct: 256 TERDKERERERDRDRDRDRR-----QKERERQTDRKRQRRTERDRETERKRERQRERERE 310
Query: 258 SSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWK 317
+ + + ++ ++ E+ K R RK K + ++ D + +
Sbjct: 311 RERNRKRERERERERERERQRETERDREKERERKRKRQ-------TEMDRERNRQTGREG 363
Query: 318 RRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAER-GSGGSSGDELRE 376
RR R RE E R R+ E R RE++++ ++R++ER + E +R G + RE
Sbjct: 364 RRQAERERERERERDRQSARE-REERERDRD-RDRQKERERQTEKDRDGQRETEKQRERE 421
Query: 377 DDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPAR 425
D ++ +GR R + + E + +R+A + K+ P R
Sbjct: 422 KDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPR 470
Score = 36.2 bits (82), Expect = 0.10
Identities = 51/296 (17%), Positives = 101/296 (34%), Gaps = 49/296 (16%)
Query: 141 ESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTS 200
E D D D+ +R+T + ++R R+ ++ E E + + E+
Sbjct: 265 ERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQR---ERERERERNRKRERER 321
Query: 201 DQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSS 260
+++ E++ R ++K++ + + + +G R A
Sbjct: 322 ERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGR--------RQAERERER 373
Query: 261 SSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRD 320
D + ++ R R ++ K R R+ + +R + E DR SE + R+
Sbjct: 374 ERERDRQSAREREERERD-RDRDRQKERERQTEKDRDGQRETEKQREREKDRESE-RGRE 431
Query: 321 EARRRELEARRRREQEEELRRLREQEK--------------------------------- 347
R RE + R R++E + R +++
Sbjct: 432 RGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWK 491
Query: 348 ---EEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSE 400
E+ + R G + S G R + +KRG+ G GR P +E
Sbjct: 492 SSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEKRGQGGEGRRPSGGFGTE 547
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 79.0 bits (193), Expect = 1e-14
Identities = 120/551 (21%), Positives = 229/551 (41%), Gaps = 68/551 (12%)
Query: 139 RMESDSDSDKSSDNSG-LKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESE 197
++ES++D+ +S S K++ + ++ R+ S+L +EE + E
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW------QEEERAHRQQQE 760
Query: 198 KTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSS 257
+ +DFT + +A ++ R GR++ A + + R+
Sbjct: 761 EEQRRDFTWQWQAEEKSER-----GRQRLSARPP-----------LREQRERQLRAEERQ 804
Query: 258 SSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDS----DEVDRI 313
+ ++ R R+ EK L + R + + + D+ R
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 314 SEWKRRDEARRRELEARRRREQ---------EEELRRLRE--QEKEEKERRRERADRGEA 362
S+ +RRD+ R +LE R+R + +E+LR+ ++ QE+EE+ +R ER R
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 363 ERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTE 422
E+ ++L++++E + + R+ R R E E + ++ K K+ Q E
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRR-------QERERQYRKDKKLQQKEEQLLGEE 977
Query: 423 P-ARKPGQKEKRVRPEEK-QQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS 480
P R+ ++EK+ R EE+ QQ + + R++ +R+ KK E EE+ Q L
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE-QLLRE 1036
Query: 481 EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA 540
E + K + +R EEL Q Q+L + + + R+Y+ +++ ++
Sbjct: 1037 ERE---KRRLQERERQYREEEEL--QQEEEQLLGEERETRRRQELERQYRKEEELQQEEE 1091
Query: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKE-KAEEKLAGEELAGEEAPQEKAEDKPSTDLS 599
++ E +K + E++ + EE+L EE E+ +E+ E + +L
Sbjct: 1092 QLLR-----------EEPEKRRRQERERQCREEEELQQEE---EQLLREEREKRRRQELE 1137
Query: 600 APVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERER 659
E Q+ E +E E R +E R E+ E + RQERER
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Query: 660 ARGDSEALDEE 670
+ E L +
Sbjct: 1198 QYREEEELQRQ 1208
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/412 (20%), Positives = 170/412 (41%), Gaps = 31/412 (7%)
Query: 277 RKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRIS------EWKRRDEARRRELEAR 330
R+ E+ L + R+ + ER + + +RI +W+ EA R+ +
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 331 RRREQEEELRRLREQEKEEKERRRE-RADRGEAERGSGGSSGDELRED------DEPVKK 383
R ++E RR QE+EEK RRRE E ER +E R D E +
Sbjct: 721 SRPRKQEGQRR--RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 384 RGRKGRGRGPPSSSDSE----PEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEK 439
RGR+ PP E E +RE + ++ + R+ +KE + EE+
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 440 QQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNA 499
Q + + ++ ++ +G D++ + +E Q+ + ++ L+ + + L A
Sbjct: 839 QLQRRERAQQLQEEEDGLQEDQERRRSQE-------QRRDQKWRWQLEEERKRRRHTLYA 891
Query: 500 LEEL-GTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAV 558
L L+ Q+LQ+ + + ++ +R + ++ + E + + ++L + E
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 559 QKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKE 618
++ + ++ + + E+L GEE + + +++ E Q+ E +E
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE----EELQQEEEQLLREE 1007
Query: 619 HEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSEALDEE 670
E+ R E + ++L + +R QERER + E L +E
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Score = 65.5 bits (158), Expect = 2e-10
Identities = 91/449 (20%), Positives = 188/449 (41%), Gaps = 63/449 (14%)
Query: 274 PRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEV----DRI----------SEWKRR 319
PR R+ E+P + R ++ + ER + S+ E DR EW+ R
Sbjct: 124 PRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER 183
Query: 320 DEARRRE--LEARRRREQEE----------ELRRLREQEKEEK-ERRRERADRGEAERGS 366
+E R E L++ + E EE EL LR + +EEK ++RRER DR E
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE--- 240
Query: 367 GGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAE----LEREAKKSAKKPQSSSTE 422
E R+ + ++K K + P + + E E LER+ + ++ + +
Sbjct: 241 --EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 423 PARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEI 482
R+ Q ++ E ++Q + + ++ R+ + ++++ +++E E++L++ E
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 483 K--FALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA 540
+ L+ + + +R E Q+ + + + +++RR + + +
Sbjct: 359 RREQQLRREQEEERREQQLRRE---QQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415
Query: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEE------LAGEEAPQEKAEDKP 594
E R + ++ + E ++ ++ E+E+ E++L E+ L EE + +++
Sbjct: 416 EQQLRREQQL---RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 595 STDLSAPVNGE--------ATSQKGESAEDKEHEEGRDSEEG-----PRCGSSEDLHDSV 641
L E ++ E E +E + R+ EE R E L +
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 642 REGPDLDRPGSDRQERERARGDSEALDEE 670
R L R +R+E+ R + + L++E
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQE 561
Score = 61.2 bits (147), Expect = 3e-09
Identities = 74/373 (19%), Positives = 144/373 (38%), Gaps = 17/373 (4%)
Query: 290 RKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEE 349
R+ + ER + + R E +R R E E + ++++L+R +E+E+ E
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 350 KERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREA 409
+ + E +R E + E E E KR + S+ + E E
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546
Query: 410 KKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEP 469
++ K+ + E R+ Q+ KR + E + Q + ER ++R + +R ++ K
Sbjct: 547 EQLLKREEEKRLEQERRE-QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605
Query: 470 SVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRR- 528
VE Q+ E + LK + P+ +R Q+L+ +++RR
Sbjct: 606 EVERLEQEERREQR--LKREEPEEER-------------RQQLLKSEEQEERRQQQLRRE 650
Query: 529 YKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQE 588
+ ++ K E RL+ R+ E ++ A E+E+A E++ + +
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 589 KAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLD 648
+A+ + S S P E ++ E E + E + + + R
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Query: 649 RPGSDRQERERAR 661
++ ER R R
Sbjct: 771 WQAEEKSERGRQR 783
Score = 58.2 bits (139), Expect = 2e-08
Identities = 79/378 (20%), Positives = 162/378 (42%), Gaps = 45/378 (11%)
Query: 317 KRRDEARRRELEARRRREQEEELRRLREQ---EKEEKERRRERADRGEAERGSGGSSGDE 373
+ R++ RR+E E R+ ++++L++ EQ E+ EK RR+ER + E
Sbjct: 946 EEREKRRRQERE--RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003
Query: 374 LREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKR 433
LRE+ E ++R R E E L E +K + + + Q+E++
Sbjct: 1004 LREEREK-RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 434 VRPEEKQQAKPVKVERTRKRSEGFSMD------------RKVEKKKEPSVEEKLQKLHSE 481
+ EE++ + ++ER ++ E + R+ E++++ EE+LQ+ +
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 482 I--KFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKA 539
+ + K +++R EE+ Q Q+L++ + + R+Y+ +++ ++
Sbjct: 1123 LLREEREKRRRQELERQYREEEEV--QQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Query: 540 AEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLS 599
++ + Q+ + E++ EE EEL ++ Q ++ +DL
Sbjct: 1181 EQL------------LREEQEKRRQERERQYREE----EELQRQKRKQRYRDEDQRSDLK 1224
Query: 600 ---APVNGEATSQKGESAEDKEHEEGRDSEEGPRCG--SSEDLHDSVREGPDLDRPGSDR 654
P A + +E+E+ R E+ S +DL + E + DR R
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR 1284
Query: 655 --QERERARGDSEALDEE 670
Q+R+R + E L+ E
Sbjct: 1285 RWQQRDRHFPEEEQLERE 1302
Score = 58.2 bits (139), Expect = 2e-08
Identities = 78/404 (19%), Positives = 169/404 (41%), Gaps = 48/404 (11%)
Query: 289 GRKPKPERPPSSSSSDSDSDEVDRISEW---KRRDEARRRELEARRRRE---QEEELRRL 342
G +P+ R + +E+ + E + R++ RR+E E + R++ Q+EE + L
Sbjct: 975 GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034
Query: 343 REQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPE 402
RE+ ++ + + RER R E E ++L ++ ++R R E E
Sbjct: 1035 REEREKRRLQERERQYREEEEL---QQEEEQLLGEERETRRRQELERQYRKEEELQQEEE 1091
Query: 403 AELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRK 462
L E +K ++ + + Q+E+++ EE+++ + ++ER + E + +
Sbjct: 1092 QLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE 1151
Query: 463 VEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVAT 522
++EP EK ++ E ++ + + + L E+ Q + ++ ++
Sbjct: 1152 QLLREEP---EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Query: 523 LKKIR------------RYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEK 570
+K R +++ K+ + +VY + G + E +++ + + +
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK------GRENEQFRQLEDSQLRDRQ 1262
Query: 571 AEEKLAGEELAGEEAPQEKAEDK-----------PSTDLSAPVNGEATSQKGESAEDK-- 617
+++ L + L GE+ +++ +++ L EA + +S E+K
Sbjct: 1263 SQQDL--QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 618 ---EHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERE 658
E EE R +E R E+ RE L R DR+ RE
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Score = 57.8 bits (138), Expect = 3e-08
Identities = 101/536 (18%), Positives = 214/536 (39%), Gaps = 90/536 (16%)
Query: 186 EEENSESSSESEKTSDQD--------FTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSK 237
EEE + ++ D+D + PEK+ AVR D+K
Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR---------------------DNK 1239
Query: 238 ADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPK-----PRGRKP 292
G + E + S + ++ R R+ + + P +
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL 1299
Query: 293 KPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRRE----QEEELRRLREQEKE 348
+ E + D S E ++ +R ++ RR+E + + R E QE E + LR QE++
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Query: 349 EKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSS---SDSEPEAEL 405
K R E + G + E+++ ++++ R+ + + E +
Sbjct: 1360 RKFREEELRHQ---------EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410
Query: 406 EREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEK-----QQAKPVKVERTRK-------- 452
+R+ K ++ Q S E RK ++E++VR +E+ ++ + ++ ER RK
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 453 -RSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKF---ALKVDSPDVKRCLNALEELGTLQV 508
E + R+ +K E++L++ + KF L+ P+ ++ L ++L Q
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE-RKFLEEEQQLHRQQR 1529
Query: 509 TSQILQKNTDVVATLK-------KIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKV 561
+ LQ+ + + + R+++ + + ++ E + R ++E QKV
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE-QKV 1588
Query: 562 NKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEE 621
+ E++ E++ ++L +E Q+ +++ D + + ++ E ++ +
Sbjct: 1589 RRQEQERKFMEDE---QQLRRQEGQQQLRQER---DRKFREDEQLLQEREEQQLHRQERD 1642
Query: 622 GRDSEEGPRCGSSE-------DLHDSVREGPDLDRPGSDRQERERARGDSEALDEE 670
+ EE P+ E D RE L + G ++Q R + R D + +EE
Sbjct: 1643 RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER-DRKFREEE 1697
Score = 57.4 bits (137), Expect = 4e-08
Identities = 69/390 (17%), Positives = 167/390 (42%), Gaps = 45/390 (11%)
Query: 291 KPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEK 350
K + E P + +++ ++ + R E R+ E + ++R +E++LRR +QE+E +
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRE-RQEEEQQQQRLRREQQLRR--KQEEERR 315
Query: 351 ERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAK 410
E++ ER ++ E +LR + E +++ + + E +L RE +
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLR------REQEEERREQQLRREQE 369
Query: 411 KSAKKPQSSSTEPARKPGQ--KEKRVRPEEK-QQAKPVKVERTRKRSEGFSMDRKVEKKK 467
+ ++ Q + R+ Q +E+++R E++ ++ + ++ E+ +R + ++++ +++
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 468 EPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIR 527
E EE+ ++ H + + ++ +R L++ + ++ R
Sbjct: 430 E---EERHEQKHEQERREQRLKREQEER--------------RDWLKREEETERHEQERR 472
Query: 528 RYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME-------KEKAEEKLAGEEL 580
+ + +D E+ E + +L+ + E ++ + E K + EE+ + L
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 581 AGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDS 640
E+ + + E++ L ++ E +E EE RD +
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL---------KREE 583
Query: 641 VREGPDLDRPGSDRQERERARGDSEALDEE 670
R L R +R E+ R + E L++E
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQE 613
Score = 57.4 bits (137), Expect = 4e-08
Identities = 73/372 (19%), Positives = 161/372 (43%), Gaps = 31/372 (8%)
Query: 308 DEVDRISEWKRRDEARRRELEARRR-----REQEE----ELRRLREQEKEEKERRRERAD 358
+E R + +RR++ RRE + RR REQEE +LRR +E+E+ E++ RRE+
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ-- 368
Query: 359 RGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELERE-----AKKSA 413
E ER ++ ++ +++ + R + E +L RE ++
Sbjct: 369 --EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 414 KKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEE 473
++ + E + ++E+R++ E++++ +K E +R E +++++ +E E
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 474 KLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANK 533
+ KL E + + ++ L +E + Q L++ + +++R + +
Sbjct: 487 RWLKLEEEER---REQQERREQQLRREQE----ERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 534 DVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDK 593
E+ E +L R ++E ++ + E+E+ ++L E EE Q++ + +
Sbjct: 540 REQEERRE---QLLKREEEKRLEQERREQRLKREQEERRDQLLKRE---EERRQQRLKRE 593
Query: 594 PSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSD 653
L + E + + ++ + + EE R + R L R +
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 654 RQERERARGDSE 665
R+E+ R + E
Sbjct: 654 RREQRLKREEEE 665
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/434 (20%), Positives = 180/434 (41%), Gaps = 56/434 (12%)
Query: 281 EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELR 340
E+ L + R RK + E S + D R E + R + R R+ ++ ++E R
Sbjct: 1405 EQQLRQDRDRKFREEE---QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461
Query: 341 RLRE-----QEKEEKERRRERADRG--EAERGSGGSSGD------ELR---------EDD 378
+ RE QE+EE++ R+ DR E E+ D ELR E++
Sbjct: 1462 KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE 1521
Query: 379 EPVKKRGR-----------KGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKP 427
+ + ++ R + + RG D + + E + ++ ++ Q S E RK
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF 1581
Query: 428 GQKEKRVRPEEKQQAKPVKVERTRKRSEGFSM-----DRKVEKKKEPSVEEKLQKLHSEI 482
+E++VR +E Q+ K ++ E+ +R EG DRK + ++ E + Q+LH +
Sbjct: 1582 RLEEQKVRRQE-QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Query: 483 KFALKVDSPDVKRCLNALEEL-----GTLQVTSQILQKNTDVVATLKKIRRYKANKDVME 537
+ ++ R ++L + Q+LQ+ + +++RR + ++ E
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE-----QQLRRQERDRKFRE 1695
Query: 538 KAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEE-APQEKAEDKPST 596
+ ++ + + R ++ Q++ + +E++ EE+ +E E+ QE+
Sbjct: 1696 EEQQLRRQERERKF---LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE 1752
Query: 597 DLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQE 656
+ P E ++ E EE E + S++ RE L + ++Q
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQL 1812
Query: 657 RERARGDSEALDEE 670
R + R +EE
Sbjct: 1813 RPQQRDGKYRWEEE 1826
Score = 52.8 bits (125), Expect = 1e-06
Identities = 56/317 (17%), Positives = 126/317 (39%), Gaps = 21/317 (6%)
Query: 186 EEENSESSSESEKTS----DQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSD 241
EEE E ++ S D+ F E++ R + +++ + + D
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 242 GAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSS 301
E + + D ++P R+ E+ L R RK + E
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 302 SSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRR------LREQEKEEKERRRE 355
+ +R +++ ++ RR+ R+ ++E++LRR RE+E+ +E +E
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 356 RADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELE--------R 407
+ R E R +++ ++++ R + R E +L R
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798
Query: 408 EAKKSAKKPQSSSTEPARKPGQ---KEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVE 464
E ++ ++ + P ++ G+ +E++++ EE++Q + +R + E F+ K
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR 1858
Query: 465 KKKEPSVEEKLQKLHSE 481
++++ +E+ QK E
Sbjct: 1859 REEQELWQEEEQKRRQE 1875
Score = 52.0 bits (123), Expect = 2e-06
Identities = 67/313 (21%), Positives = 128/313 (40%), Gaps = 45/313 (14%)
Query: 320 DEARRRELEARRR----REQEEELRRL--REQEKEEKERRRERADRGEAERGSGGSSGDE 373
DE +R + + R QEE+ RR R+++ EE+ +R R R E ER + G+E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL--AEGEE 153
Query: 374 LREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKR 433
E E +++R R+ R E E R ++ + + TE Q +R
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 434 VRPEEKQQAKPVKVERTRKRSEG-FSMDRKVEKKKEPSV----EEKLQKLHSEIKFALKV 488
E +++ + K ++ R+R + F + + E +K +V EEKLQ+
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE----------- 262
Query: 489 DSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKS 548
+ P +R L EE L+K+ R + ++ E+ + +
Sbjct: 263 EEPQRQRELQEEEE-------------------QLRKLERQELRRERQEEEQQQQRLRRE 303
Query: 549 RVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATS 608
+ L K E ++ + E+ + +E+ +E E+ + + E++ L E
Sbjct: 304 QQLRRKQEEERREQQE--ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361
Query: 609 QKGESAEDKEHEE 621
Q+ +++E E
Sbjct: 362 QQLRREQEEERRE 374
Score = 50.1 bits (118), Expect = 7e-06
Identities = 70/377 (18%), Positives = 159/377 (42%), Gaps = 28/377 (7%)
Query: 288 RGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLR---- 343
R RK + E + +R +++ ++ RR+ + R+ E E++LRR
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Query: 344 -EQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPE 402
QE++ K R E+ + E+ D ++EP +R + R D + +
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR----QEREQQLRHDRDRK 1668
Query: 403 AELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRK 462
E + + ++ Q E RK ++E+++R +E+++ K ++ E+ +R E ++RK
Sbjct: 1669 FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER-KFLQEEQQLRRQE---LERK 1724
Query: 463 VEKKKEPSVEEKLQKLHSEIKFALKVDSPDVK-----RCLNALEELGTLQVTSQILQKNT 517
++++ E + ++L + ++ ++ ++ + L E + Q+ Q+
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Query: 518 DVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAG 577
+ +++R ++++ E+ +L+ ++ Q+ K E+E+ + +
Sbjct: 1785 E-----QQLRSQESDRKFREE-----EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834
Query: 578 EELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDL 637
+ L E Q +AE++ +T + + Q+ E +E E E R E
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 638 HDSVREGPDLDRPGSDR 654
H V E + G R
Sbjct: 1895 HRQVGEIKSQEGKGHGR 1911
Score = 47.8 bits (112), Expect = 3e-05
Identities = 77/417 (18%), Positives = 165/417 (39%), Gaps = 27/417 (6%)
Query: 278 KPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEE 337
K E+ + R ++ + ER + + + E + R E R + E R ++E
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 338 ELRRLREQEKEE------------KERRRERADRGEAERGSGGSSGDELREDDEPVKKRG 385
+RL+ +E EE +ERR+++ R + ER +E E E KR
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 386 RKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPV 445
+ R ++ E E ER + K +E + + R R +E Q+ +
Sbjct: 676 HE-EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734
Query: 446 KVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNA---LEE 502
+ E+ R+R + + E++ +E+ Q+ ++ + S ++ L+A L E
Sbjct: 735 QEEKRRRRES--ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 503 LGTLQVTSQ--------ILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPK 554
Q+ ++ L + + ++ R + +E+ ++ R +++ L +
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 555 IEAVQKVNKAGMEKEKAEEKLAGEELAGE-EAPQEKAEDKPSTDLSAPVNGEATSQKGES 613
+ +Q+ + +E+ ++ +L E + + KP+ + ++ E
Sbjct: 853 EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912
Query: 614 AEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSEALDEE 670
+ +E E+ R E+ + E L + +R RQERER + L ++
Sbjct: 913 LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Score = 47.8 bits (112), Expect = 3e-05
Identities = 73/366 (19%), Positives = 152/366 (41%), Gaps = 58/366 (15%)
Query: 318 RRDEARRRELEARRRREQEEELRRLREQ---EKEEKERRRERADRGEAERGSGGSSGDEL 374
R + +RR E R+ +EEEL++ EQ E+ EK RR+E + E +E+
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE--------EEV 1146
Query: 375 REDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRV 434
++++E + + + R R E E + E + ++ Q E ++ ++E++
Sbjct: 1147 QQEEEQLLREEPEKRRR-------QELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 435 RPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSV-----------EEKLQKLHSEIK 483
R EE+ Q + K +R R + + + E +KE +V E+ ++L + +
Sbjct: 1200 REEEELQRQKRK-QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL-EDSQ 1257
Query: 484 FALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVY 543
+ D++ L +E Q + Q++ R+ ++ +E+ +
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRD-----------RHFPEEEQLEREEQKE 1306
Query: 544 TRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVN 603
+ + R + + +++ + +++ + K E E+ QE+ E P+
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE----EQLLQEREEQ--------PLR 1354
Query: 604 GEATSQKGESAEDKEHEEGRD-SEEGPRCGSSEDLHDSVREGPDL---DRPGSDRQERER 659
+ +K E + E+GR EE R E ++E L +R RQ+R+R
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 660 ARGDSE 665
+ E
Sbjct: 1415 KFREEE 1420
Score = 43.1 bits (100), Expect = 8e-04
Identities = 63/369 (17%), Positives = 150/369 (40%), Gaps = 29/369 (7%)
Query: 317 KRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELRE 376
+ ++ R E E RRR+E E + R E+EE ++ E+ R E E+ + RE
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYR-----EEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172
Query: 377 DDEPVKKRGRKGRGRGPPSSSDSE----PEAELEREAKKSAKKPQSSST------EPARK 426
++E ++ + R + E E EL+R+ +K + + + EP ++
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232
Query: 427 PGQKEKRV--RPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKF 484
++ +V + E +Q + ++ + R R + + +++E E++ ++ +
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 485 ALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKI-RRYKANKDVMEKAAEVY 543
+ + + + A Q Q+L++ + ++ R+++ + ++++ E
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 544 TRLKSRVLGPKIEAV--QKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAP 601
R + R + E + Q+ + +E+E+ + E +E Q + +++
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQ------ 1406
Query: 602 VNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERAR 661
+ + ++E + R + + + RE L+ RQER R
Sbjct: 1407 ---QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKF 1463
Query: 662 GDSEALDEE 670
+ E L +E
Sbjct: 1464 REEEQLLQE 1472
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/361 (26%), Positives = 152/361 (42%), Gaps = 25/361 (6%)
Query: 142 SDSDSDK-SSDNSGLKRKTPALKMSVSKRARKASSDLDQASV-SPSEEENSESSSESEKT 199
S SD++K S G LK + R SS + + S S ++E SSE K
Sbjct: 1070 SSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKK 1129
Query: 200 SDQDFTPEKKAA-VRAPRRGPLGGRKKKKAP---SASDSDSKAD---------SDGAKPE 246
Q + +KKA V+ +R L K+K S+S SD + D SD K +
Sbjct: 1130 KKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIK 1189
Query: 247 PVAMARSASSSSS-SSSSSDSDVSVKKPPRGRKPAEKPLPKPR-GRKPKPERPPSSSSSD 304
PV SS + SS D +S P + P+ R +K E ++ SSD
Sbjct: 1190 PVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD 1249
Query: 305 SDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAER 364
D D E K+R + E + + + E+ +K R R R R +
Sbjct: 1250 EDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTV 1309
Query: 365 GSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEP----EAELEREAKKSAKKPQSSS 420
S G SG+E + +P + + KGR R SS DSE E+ + E +S + Q
Sbjct: 1310 -SDGESGEEKKT--KPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDE-QRPR 1365
Query: 421 TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS 480
T A+K +E + ++K++ + +KV+ + + + E+K+E EE+ ++
Sbjct: 1366 TRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1425
Query: 481 E 481
E
Sbjct: 1426 E 1426
Score = 73.2 bits (178), Expect = 7e-13
Identities = 105/457 (22%), Positives = 186/457 (40%), Gaps = 44/457 (9%)
Query: 142 SDSDSDKSS-DNSGLKRKTPALKMSVSKRARKASS--------DLDQASVSPSEEENSES 192
S SD+++SS DN K++T + K +V + +K +S D S S S+ E+ +
Sbjct: 1116 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1175
Query: 193 SSESEKTSD-QDFTPEKKAAVRAPRRG---PLGGRKKKKAPSASDSDSKADSDGAKPEPV 248
+S E +SD Q P + V + G G K+ + D D+D PE
Sbjct: 1176 NSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDND---PENR 1232
Query: 249 AMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSD 308
+ ++ SSD D S P K K K P E + +S+SDSD
Sbjct: 1233 IAKKMLLEEIKANLSSDEDGSSDDEPEEGK---KRTGKQNEENPGDEEAKNQVNSESDSD 1289
Query: 309 EVDRISEWKRRDEARRRELEARRR---REQEEELRRLREQEKEEKERRRERADRGEAERG 365
SE ++ R R L + E EE + ++ KE K R R + ++E
Sbjct: 1290 -----SEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS 1344
Query: 366 SGGSSG--DELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEP 423
SG +E+ E ++ + R R + + E + +++ K+ K Q S+
Sbjct: 1345 DFQESGVSEEVSESEDEQRPRTRSAK-----KAELEENQRSYKQKKKRRRIKVQEDSSSE 1399
Query: 424 ARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQ--KLHSE 481
+ ++E+ + EE+++ E + E + D K K + + L+ KL +E
Sbjct: 1400 NKSNSEEEEEEKEEEEEEE-----EEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTE 1454
Query: 482 IKFALKVDSPDVKRCLNALEELGTLQVTSQILQKN-TDVVATLKKIRRYKANKDVMEKAA 540
+ ALK + KR E L+ +I + T T K + +++ E
Sbjct: 1455 TQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLV--LDEDEETKEPLV 1512
Query: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAG 577
+V+ + ++ +++ VQ + E K +K G
Sbjct: 1513 QVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPG 1549
Score = 64.3 bits (155), Expect = 3e-10
Identities = 131/673 (19%), Positives = 235/673 (34%), Gaps = 127/673 (18%)
Query: 84 IQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVT-----AVTATAASD 138
+ N H + SS D+E + S D+D +M + A+A++D
Sbjct: 822 MDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTD 881
Query: 139 RMESDSDSDKSSDN------SGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSES 192
++ S ++S + + K K+ LK K+ + SD+ + + +++ S+
Sbjct: 882 GVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL---KKDQSDE 938
Query: 193 SSESEKTSDQDFTPEKK---------------------AAVRAPRRG-----PLGGRKKK 226
+SE +K + T EKK + P R P G ++ K
Sbjct: 939 TSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIK 998
Query: 227 KAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPK 286
+ + SK D + ++ A S+ S DS KK G EK K
Sbjct: 999 NGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED-KKSKNGAYGREKKRCK 1057
Query: 287 PRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQE 346
G+ + + SSS ++ S + D + +R L+R+
Sbjct: 1058 LLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKR-------------------LKRI---- 1094
Query: 347 KEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELE 406
E +ERR + R E SG SS D E E KK+ ++ + + L
Sbjct: 1095 -ELRERRNLSSKRNTKEIQSGSSSSD-AEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLR 1152
Query: 407 REAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGF---SMDRKV 463
K+ SSS+ Q ++Q+ KPV GF S D +
Sbjct: 1153 TSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL 1212
Query: 464 EKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEE--------------------- 502
K +V++ E + A K+ ++K L++ E+
Sbjct: 1213 SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEEN 1272
Query: 503 LGTLQVTSQILQKNTDVVATLKKIR------RYKANKDVMEKAAEVYTRLKSRVLGPKIE 556
G + +Q+ ++ KK R R+K E E T+ K +
Sbjct: 1273 PGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEH------K 1326
Query: 557 AVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLS----------------- 599
V+ N+ + E +E+ E EE + + E +P T +
Sbjct: 1327 EVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKK 1386
Query: 600 ---APVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQE 656
V +++S+ ++E++E E+ + EE E+ + E D PG R++
Sbjct: 1387 RRRIKVQEDSSSENKSNSEEEEEEKEEEEEE-----EEEEEEEEEDENDDSKSPGKGRKK 1441
Query: 657 RERARGDSEALDE 669
+ D + E
Sbjct: 1442 IRKILKDDKLRTE 1454
Score = 64.3 bits (155), Expect = 3e-10
Identities = 118/509 (23%), Positives = 197/509 (38%), Gaps = 91/509 (17%)
Query: 131 VTATAASDRMESDSDS--DKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEE 188
+T++++SD + D +S + SSD +K T L +S ++S D E
Sbjct: 1162 ITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGD----------EA 1211
Query: 189 NSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSD------- 241
S+S + D D PE + A + ++ KA +SD D +D +
Sbjct: 1212 LSKSVPVTVDDDDDDNDPENRIAKKMLL-------EEIKANLSSDEDGSSDDEPEEGKKR 1264
Query: 242 -GAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGR-------------------KPAE 281
G + E A + +S S SDS+ S K R R KP E
Sbjct: 1265 TGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKE 1324
Query: 282 KPLPKPRGRKPKPERPPSSSSSDSDSDEV---DRISEWK-----RRDEARRRELEARRRR 333
K R R+ + S S DSD E + +SE + R A++ ELE +R
Sbjct: 1325 HKEVKGRNRR----KVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRS 1380
Query: 334 -EQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRG 392
+Q+++ RR++ QE E + + E E +E E++E + K G+G
Sbjct: 1381 YKQKKKRRRIKVQEDSSSENKSNSEE--EEEEKEEEEEEEEEEEEEEEDENDDSKSPGKG 1438
Query: 393 PPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRK 452
+ +L E + + K+ + A + ++EK E + A P K T K
Sbjct: 1439 RKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTK 1498
Query: 453 RSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKR-----CLNALEEL---- 503
+D E+ KEP V+ +H + LK D + C ++++
Sbjct: 1499 ----LVLDED-EETKEPLVQ-----VHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSP 1548
Query: 504 --GTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKV 561
G + L K VV+ L + ++ + T L L + + +
Sbjct: 1549 GSGCILAHCMGLGKTLQVVSFLHTV--------LLCDKLDFSTALVVCPLNTALNWMNEF 1600
Query: 562 NKAGMEKEKAEEKLAGEELAGEEAPQEKA 590
K E K +EKL ELA + PQE++
Sbjct: 1601 EK-WQEGLKDDEKLEVSELATVKRPQERS 1628
Score = 53.1 bits (126), Expect = 8e-07
Identities = 80/412 (19%), Positives = 154/412 (37%), Gaps = 33/412 (8%)
Query: 96 PPVSSSDSEAP-EANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSG 154
P V ++ P E NP + +E +E +V R SDS D N
Sbjct: 619 PRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPN-- 676
Query: 155 LKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRA 214
K P K S + +SD D+ E SS S+ ++ T K
Sbjct: 677 ---KLPKSKQSETV---DQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLK 730
Query: 215 PRRGPLGGRKKKKAPSASDSD-SKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKP 273
+ G K+K+ S S SD AK ++ + + S SS+ S+ + +K
Sbjct: 731 TQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSM 790
Query: 274 PR--GRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRE----- 326
+ + +K +P + + S D+ + + S+ D+A R++
Sbjct: 791 SKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETF 850
Query: 327 LEARRRREQEEELRRLREQ--EKEEKERRRERADRGEAERGSGGS----SGDELREDDEP 380
A +++ + LR++ +K++ + D+ + S S E +E +
Sbjct: 851 SSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKH 910
Query: 381 VKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQ-KEKRVRPEEK 439
+K + K G ++ + + E + KK TE +KP K+K ++ E++
Sbjct: 911 LKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQ 970
Query: 440 QQAKPVKVERTRKRSEGFSMDRKVE---------KKKEPSVEEKLQKLHSEI 482
++ E+ +R E + ++ +KK + +K K E+
Sbjct: 971 YESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDEL 1022
Score = 52.4 bits (124), Expect = 1e-06
Identities = 59/240 (24%), Positives = 86/240 (35%), Gaps = 19/240 (7%)
Query: 100 SSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDK----------S 149
SSD E E G +E+ D A V + + SD ES + S
Sbjct: 1253 SSDDEPEEGKKRTGKQNEENPGDEE--AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1310
Query: 150 SDNSGLKRKT-PALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEK 208
SG ++KT P V R R+ S D E SE SESE K
Sbjct: 1311 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAK 1370
Query: 209 KAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDV 268
KA + +R +K+++ DS S+ S+ + E D +
Sbjct: 1371 KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND 1430
Query: 269 SVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELE 328
K P +GRK K L K R + ++ + + RI+E +R E R +E
Sbjct: 1431 DSKSPGKGRKKIRKIL------KDDKLRTETQNALKEEEERRKRIAEREREREKLREVIE 1484
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/361 (26%), Positives = 152/361 (42%), Gaps = 25/361 (6%)
Query: 142 SDSDSDK-SSDNSGLKRKTPALKMSVSKRARKASSDLDQASV-SPSEEENSESSSESEKT 199
S SD++K S G LK + R SS + + S S ++E SSE K
Sbjct: 1108 SSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKK 1167
Query: 200 SDQDFTPEKKAA-VRAPRRGPLGGRKKKKAP---SASDSDSKAD---------SDGAKPE 246
Q + +KKA V+ +R L K+K S+S SD + D SD K +
Sbjct: 1168 KKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIK 1227
Query: 247 PVAMARSASSSSS-SSSSSDSDVSVKKPPRGRKPAEKPLPKPR-GRKPKPERPPSSSSSD 304
PV SS + SS D +S P + P+ R +K E ++ SSD
Sbjct: 1228 PVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD 1287
Query: 305 SDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAER 364
D D E K+R + E + + + E+ +K R R R R +
Sbjct: 1288 EDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTV 1347
Query: 365 GSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEP----EAELEREAKKSAKKPQSSS 420
S G SG+E + +P + + KGR R SS DSE E+ + E +S + Q
Sbjct: 1348 -SDGESGEEKKT--KPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDE-QRPR 1403
Query: 421 TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS 480
T A+K +E + ++K++ + +KV+ + + + E+K+E EE+ ++
Sbjct: 1404 TRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1463
Query: 481 E 481
E
Sbjct: 1464 E 1464
Score = 73.2 bits (178), Expect = 7e-13
Identities = 105/457 (22%), Positives = 186/457 (40%), Gaps = 44/457 (9%)
Query: 142 SDSDSDKSS-DNSGLKRKTPALKMSVSKRARKASS--------DLDQASVSPSEEENSES 192
S SD+++SS DN K++T + K +V + +K +S D S S S+ E+ +
Sbjct: 1154 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1213
Query: 193 SSESEKTSD-QDFTPEKKAAVRAPRRG---PLGGRKKKKAPSASDSDSKADSDGAKPEPV 248
+S E +SD Q P + V + G G K+ + D D+D PE
Sbjct: 1214 NSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDND---PENR 1270
Query: 249 AMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSD 308
+ ++ SSD D S P K K K P E + +S+SDSD
Sbjct: 1271 IAKKMLLEEIKANLSSDEDGSSDDEPEEGK---KRTGKQNEENPGDEEAKNQVNSESDSD 1327
Query: 309 EVDRISEWKRRDEARRRELEARRR---REQEEELRRLREQEKEEKERRRERADRGEAERG 365
SE ++ R R L + E EE + ++ KE K R R + ++E
Sbjct: 1328 -----SEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS 1382
Query: 366 SGGSSG--DELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEP 423
SG +E+ E ++ + R R + + E + +++ K+ K Q S+
Sbjct: 1383 DFQESGVSEEVSESEDEQRPRTRSAK-----KAELEENQRSYKQKKKRRRIKVQEDSSSE 1437
Query: 424 ARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQ--KLHSE 481
+ ++E+ + EE+++ E + E + D K K + + L+ KL +E
Sbjct: 1438 NKSNSEEEEEEKEEEEEEE-----EEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTE 1492
Query: 482 IKFALKVDSPDVKRCLNALEELGTLQVTSQILQKN-TDVVATLKKIRRYKANKDVMEKAA 540
+ ALK + KR E L+ +I + T T K + +++ E
Sbjct: 1493 TQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLV--LDEDEETKEPLV 1550
Query: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAG 577
+V+ + ++ +++ VQ + E K +K G
Sbjct: 1551 QVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPG 1587
Score = 64.3 bits (155), Expect = 3e-10
Identities = 131/673 (19%), Positives = 235/673 (34%), Gaps = 127/673 (18%)
Query: 84 IQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVT-----AVTATAASD 138
+ N H + SS D+E + S D+D +M + A+A++D
Sbjct: 860 MDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTD 919
Query: 139 RMESDSDSDKSSDN------SGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSES 192
++ S ++S + + K K+ LK K+ + SD+ + + +++ S+
Sbjct: 920 GVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFL---KKDQSDE 976
Query: 193 SSESEKTSDQDFTPEKK---------------------AAVRAPRRG-----PLGGRKKK 226
+SE +K + T EKK + P R P G ++ K
Sbjct: 977 TSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIK 1036
Query: 227 KAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPK 286
+ + SK D + ++ A S+ S DS KK G EK K
Sbjct: 1037 NGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED-KKSKNGAYGREKKRCK 1095
Query: 287 PRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQE 346
G+ + + SSS ++ S + D + +R L+R+
Sbjct: 1096 LLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKR-------------------LKRI---- 1132
Query: 347 KEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELE 406
E +ERR + R E SG SS D E E KK+ ++ + + L
Sbjct: 1133 -ELRERRNLSSKRNTKEIQSGSSSSD-AEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLR 1190
Query: 407 REAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGF---SMDRKV 463
K+ SSS+ Q ++Q+ KPV GF S D +
Sbjct: 1191 TSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL 1250
Query: 464 EKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEE--------------------- 502
K +V++ E + A K+ ++K L++ E+
Sbjct: 1251 SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEEN 1310
Query: 503 LGTLQVTSQILQKNTDVVATLKKIR------RYKANKDVMEKAAEVYTRLKSRVLGPKIE 556
G + +Q+ ++ KK R R+K E E T+ K +
Sbjct: 1311 PGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEH------K 1364
Query: 557 AVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLS----------------- 599
V+ N+ + E +E+ E EE + + E +P T +
Sbjct: 1365 EVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKK 1424
Query: 600 ---APVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQE 656
V +++S+ ++E++E E+ + EE E+ + E D PG R++
Sbjct: 1425 RRRIKVQEDSSSENKSNSEEEEEEKEEEEEE-----EEEEEEEEEDENDDSKSPGKGRKK 1479
Query: 657 RERARGDSEALDE 669
+ D + E
Sbjct: 1480 IRKILKDDKLRTE 1492
Score = 64.3 bits (155), Expect = 3e-10
Identities = 118/509 (23%), Positives = 197/509 (38%), Gaps = 91/509 (17%)
Query: 131 VTATAASDRMESDSDS--DKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEE 188
+T++++SD + D +S + SSD +K T L +S ++S D E
Sbjct: 1200 ITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGD----------EA 1249
Query: 189 NSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSD------- 241
S+S + D D PE + A + ++ KA +SD D +D +
Sbjct: 1250 LSKSVPVTVDDDDDDNDPENRIAKKMLL-------EEIKANLSSDEDGSSDDEPEEGKKR 1302
Query: 242 -GAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGR-------------------KPAE 281
G + E A + +S S SDS+ S K R R KP E
Sbjct: 1303 TGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKE 1362
Query: 282 KPLPKPRGRKPKPERPPSSSSSDSDSDEV---DRISEWK-----RRDEARRRELEARRRR 333
K R R+ + S S DSD E + +SE + R A++ ELE +R
Sbjct: 1363 HKEVKGRNRR----KVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRS 1418
Query: 334 -EQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRG 392
+Q+++ RR++ QE E + + E E +E E++E + K G+G
Sbjct: 1419 YKQKKKRRRIKVQEDSSSENKSNSEE--EEEEKEEEEEEEEEEEEEEEDENDDSKSPGKG 1476
Query: 393 PPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRK 452
+ +L E + + K+ + A + ++EK E + A P K T K
Sbjct: 1477 RKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTK 1536
Query: 453 RSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKR-----CLNALEEL---- 503
+D E+ KEP V+ +H + LK D + C ++++
Sbjct: 1537 ----LVLDED-EETKEPLVQ-----VHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSP 1586
Query: 504 --GTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKV 561
G + L K VV+ L + ++ + T L L + + +
Sbjct: 1587 GSGCILAHCMGLGKTLQVVSFLHTV--------LLCDKLDFSTALVVCPLNTALNWMNEF 1638
Query: 562 NKAGMEKEKAEEKLAGEELAGEEAPQEKA 590
K E K +EKL ELA + PQE++
Sbjct: 1639 EK-WQEGLKDDEKLEVSELATVKRPQERS 1666
Score = 53.1 bits (126), Expect = 8e-07
Identities = 80/412 (19%), Positives = 154/412 (37%), Gaps = 33/412 (8%)
Query: 96 PPVSSSDSEAP-EANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSG 154
P V ++ P E NP + +E +E +V R SDS D N
Sbjct: 657 PRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPN-- 714
Query: 155 LKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRA 214
K P K S + +SD D+ E SS S+ ++ T K
Sbjct: 715 ---KLPKSKQSETV---DQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLK 768
Query: 215 PRRGPLGGRKKKKAPSASDSD-SKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKP 273
+ G K+K+ S S SD AK ++ + + S SS+ S+ + +K
Sbjct: 769 TQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSM 828
Query: 274 PR--GRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRE----- 326
+ + +K +P + + S D+ + + S+ D+A R++
Sbjct: 829 SKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETF 888
Query: 327 LEARRRREQEEELRRLREQ--EKEEKERRRERADRGEAERGSGGS----SGDELREDDEP 380
A +++ + LR++ +K++ + D+ + S S E +E +
Sbjct: 889 SSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKH 948
Query: 381 VKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQ-KEKRVRPEEK 439
+K + K G ++ + + E + KK TE +KP K+K ++ E++
Sbjct: 949 LKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQ 1008
Query: 440 QQAKPVKVERTRKRSEGFSMDRKVE---------KKKEPSVEEKLQKLHSEI 482
++ E+ +R E + ++ +KK + +K K E+
Sbjct: 1009 YESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDEL 1060
Score = 52.4 bits (124), Expect = 1e-06
Identities = 59/240 (24%), Positives = 86/240 (35%), Gaps = 19/240 (7%)
Query: 100 SSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDK----------S 149
SSD E E G +E+ D A V + + SD ES + S
Sbjct: 1291 SSDDEPEEGKKRTGKQNEENPGDEE--AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1348
Query: 150 SDNSGLKRKT-PALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEK 208
SG ++KT P V R R+ S D E SE SESE K
Sbjct: 1349 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAK 1408
Query: 209 KAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDV 268
KA + +R +K+++ DS S+ S+ + E D +
Sbjct: 1409 KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND 1468
Query: 269 SVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELE 328
K P +GRK K L K R + ++ + + RI+E +R E R +E
Sbjct: 1469 DSKSPGKGRKKIRKIL------KDDKLRTETQNALKEEEERRKRIAEREREREKLREVIE 1522
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 76.6 bits (187), Expect = 7e-14
Identities = 103/479 (21%), Positives = 185/479 (38%), Gaps = 65/479 (13%)
Query: 172 KASSDLDQASVSPSEEENSESSSESEKTSDQD---------FTPEKKAAVRAPRRGPLGG 222
KA + P N + + E+T +D E + + AP +
Sbjct: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSH 232
Query: 223 RKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEK 282
+KKK D + P P+ ++ D + + + K
Sbjct: 233 PRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDL---ISREISKFRDTHK 289
Query: 283 PLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRL 342
L + +G+K K + E+++ E + R+ R RE E RR RE+E E R
Sbjct: 290 KLEEEKGKKEK------------ERQEIEK--ERRERERERERERE-RRERERERERERE 334
Query: 343 REQEKE-EKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEP 401
RE+EKE E+ER R+R DR + + R+ D K R R S D E
Sbjct: 335 REKEKERERERERDR-DRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRER 393
Query: 402 EAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDR 461
E E ERE ++ E R+ ++ +R R E+++ K K +R + + R
Sbjct: 394 ERERERERER--------EREREREREREREREREREREREKDKKRDREEDEEDAYER-R 444
Query: 462 KVEKK---KEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTD 518
K+E+K KE + +E+L+ + + + +R EE ++ +
Sbjct: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAER-----EE-----------ERRRE 488
Query: 519 VVATLKKIRRYKANKDVMEKAAEVY--TRLKSRVLGPKIEAVQKVNKAGMEKEKAEE--- 573
+ K+++ + + D + Y + L+ R+ + E EKE+ EE
Sbjct: 489 MAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQ 548
Query: 574 KLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGE---SAEDKEHEEGRDSEEGP 629
+L E +A ++ E + + E S++ E ++++ EE + EE P
Sbjct: 549 RLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEP 607
Score = 53.5 bits (127), Expect = 6e-07
Identities = 85/447 (19%), Positives = 153/447 (34%), Gaps = 67/447 (14%)
Query: 82 WEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRME 141
W+ + + P V++ D EA DE+ + R M A+ E
Sbjct: 172 WKAKKKASNGNARPETVTNDDEEA----------LDEETKRRDQMIKGAIEVLIREYSSE 221
Query: 142 SDSDSDKSSDNSGLKRKTP-------------------------ALKMSVSKRA------ 170
++ S +S + K+K A++M KR
Sbjct: 222 LNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREI 281
Query: 171 ---RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKK 227
R L++ +E E+ +++ E++ R R ++K+
Sbjct: 282 SKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERER---EREKE 338
Query: 228 APSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKP 287
+ + D D K R SSD + + + E+ +
Sbjct: 339 KERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERE 398
Query: 288 RGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELR------- 340
R R+ + ER E +R E ++ + E +A RR+ E +LR
Sbjct: 399 REREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQ 458
Query: 341 -RLREQEKEEKERRRE---RADRGEAERGSGGSSGDELRE--------DDEPVKKRGRKG 388
RL+ E E+++ RE A+R E R L+E D+P RG
Sbjct: 459 ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSAL 518
Query: 389 RGRGPPSSSDSE-PEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKV 447
+ R + E E + +RE ++ + Q E P + +R+ E +++ +P
Sbjct: 519 QKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIK 578
Query: 448 ERTRKRSEGFSMDRKVEKKKEPSVEEK 474
+ E K EK++EP EE+
Sbjct: 579 QEPESEEEEEEKQEKEEKREEPMEEEE 605
Score = 51.2 bits (121), Expect = 3e-06
Identities = 71/347 (20%), Positives = 126/347 (36%), Gaps = 63/347 (18%)
Query: 140 MESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKT 199
ME D S + S + L+ K+ ++ + E E E E+
Sbjct: 269 MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE 328
Query: 200 SDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSS 259
+++ EK+ R + K+ D + D D + RS S S
Sbjct: 329 REREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
Query: 260 SSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVD-------- 311
+ + ++ + E+ + R R+ + ER D + DE D
Sbjct: 389 RDRERERERERERERERERERERERERERERERERERE-KDKKRDREEDEEDAYERRKLE 447
Query: 312 ------------RISEWK--------------RRDEARRREL--EARRRREQEEEL---- 339
R+ W+ R+E RRRE+ EA+R +E E+
Sbjct: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
Query: 340 ------------RRLREQEKE----EKERRRERADRGEAER---GSGGSSGDELREDDEP 380
+RLR++EKE E++R+RE+ + E + G D + E
Sbjct: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQ 567
Query: 381 VKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKP 427
+R R+ + + P +SE E E ++E ++ ++P EP +KP
Sbjct: 568 EAERRRQPQIKQEP---ESEEEEEEKQEKEEKREEPMEEEEEPEQKP 611
Score = 40.0 bits (92), Expect = 0.007
Identities = 51/251 (20%), Positives = 104/251 (41%), Gaps = 19/251 (7%)
Query: 428 GQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALK 487
G+K+ V+ + K +A+ + + +K S G + V E +++E+ ++ IK A++
Sbjct: 153 GEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIE 212
Query: 488 VDSPDVKRCLNALEELGTLQVTSQILQKNTDV-----VATL---KKIRRYKANKDVMEKA 539
V + LNA + + +K D+ VA L I + N ME+
Sbjct: 213 VLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEED 272
Query: 540 AEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLS 599
K ++ +I + +K +E+EK +++ +E+ E +E+ ++
Sbjct: 273 -------KRDLISREISKFRDTHKK-LEEEKGKKEKERQEIEKERRERERERERERERRE 324
Query: 600 APVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERER 659
E ++ E ++KE E R+ + D D DR S + ++R
Sbjct: 325 RERERE---REREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDR 381
Query: 660 ARGDSEALDEE 670
+R ++ D E
Sbjct: 382 SRSREKSRDRE 392
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 75.9 bits (185), Expect = 1e-13
Identities = 84/382 (21%), Positives = 147/382 (38%), Gaps = 41/382 (10%)
Query: 88 PHASYSAPP--PVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSD 145
P S+++ P P S SE E + D DA+ D+ G T + SD
Sbjct: 283 PPPSWASEPERPSILSASELKELDKFDNLDAEADEGWAGAQMEVDYTEQL------NFSD 336
Query: 146 SDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFT 205
D+ NS K ++ DQ S + EN + + E T
Sbjct: 337 DDEQGSNSP-----------------KENNSEDQGSKASENNENKKETDEVSNTKSSSQI 379
Query: 206 PEKKAAVRAPR-RGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSS 264
P + + + P +GP +++ + P+ A+ S +
Sbjct: 380 PAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVA 439
Query: 265 DSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEW-----KRR 319
D D K+ R + + + R R+ + ER + ++++ R+ E K+
Sbjct: 440 DEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQP 499
Query: 320 DEARRRELEARRRREQEEELRRLREQEKE-EKERRRERADRGEAERGSGGSSGDEL---- 374
RE E + RE+E+EL + +EQE+E E+E+ RER E E E+
Sbjct: 500 SPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKER 559
Query: 375 -REDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKR 433
+E ++ ++++ K + + E E E ERE + +P+ + EP + + E
Sbjct: 560 KQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENS 619
Query: 434 VRPEEKQQAKPVKVERTRKRSE 455
EE +PV + RSE
Sbjct: 620 CNKEE----EPVFTRQDSNRSE 637
Score = 74.7 bits (182), Expect = 3e-13
Identities = 73/277 (26%), Positives = 126/277 (45%), Gaps = 31/277 (11%)
Query: 222 GRKKKKAPSASDSDSKADSDGA-KPEPVAMARSASSSSSSSSSSDSDVSVKKPP-----R 275
G K ++ D SKA + K E ++ + SSS + S + V K P R
Sbjct: 341 GSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQER 400
Query: 276 GRKPAEKPLPK-------PRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELE 328
G P PK P R+ P RP S +DE D I + +RR ++
Sbjct: 401 GTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADE-DEIWKQRRRQQSEISAAV 459
Query: 329 ARRRREQEEELRRLREQEKEEKERRRERADR--GEAERGSGGSSGDELREDDEPVKKRGR 386
R R+ +EEE RR+ EQ K + +R D G E+ S +E+RE + K+R R
Sbjct: 460 ERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQP---SPEEIRERERE-KERER 515
Query: 387 KGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVK 446
+ E E E E+E +K +K + E ++ +++++ R EK++ + +
Sbjct: 516 -----------EKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKE 564
Query: 447 VERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIK 483
E R++ + + + E++KE +E++ +KL +I+
Sbjct: 565 KELERQKEKEKELQKMKEQEKECELEKEREKLEEKIE 601
Score = 54.3 bits (129), Expect = 4e-07
Identities = 131/630 (20%), Positives = 232/630 (36%), Gaps = 83/630 (13%)
Query: 55 PKDLFPYDKCKDKYGKPNKRKGFNEGL-WEIQNNPHASYSAP--PPVSSSDSEA--PEAN 109
P P K ++K PN +G W + H P PP A PE
Sbjct: 56 PPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKTPEVPPAQPKPGVAAPPEVA 115
Query: 110 PADGSDADEDDEDRG---------VMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTP 160
PA S A +G ++ A ++ E +++ D L+
Sbjct: 116 PAPKSWASNKQGGQGDGIQVNSQFQQEFPSLQAAGDQEKKEKETNDDNYGPGPSLRPPNV 175
Query: 161 ALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPL 220
A K A SS DQ P ++E++ +SE +D EK+ A P + L
Sbjct: 176 ACWRDGGKAAGSPSSS-DQDEKLPGQDESTAGTSEQ---NDILKVVEKRIAC-GPPQAKL 230
Query: 221 GGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPA 280
G++ A AS + + P M S S+ + K RGR P
Sbjct: 231 NGQQ---AALASQYRAMMPPYMFQQYP-RMTYPPLHGPMRFPPSLSETN--KGLRGRGP- 283
Query: 281 EKPLPKPRGRKPKPERPPSSSSSD-SDSDEVDRISEWKRRDEARRRELEARRRREQEEEL 339
P +PERP S+S+ + D+ D + EA A+ + E+L
Sbjct: 284 ------PPSWASEPERPSILSASELKELDKFDNLDA-----EADEGWAGAQMEVDYTEQL 332
Query: 340 RRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGR---------- 389
+ E+ + ++ ++GS S +E +++ + V +
Sbjct: 333 NFSDDDEQGSNSPKENNSE----DQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKV 388
Query: 390 --GRGPPSSSDSEPEAELEREAKKSAKK--PQSSSTEPARK-PGQKEKRVRPEE------ 438
G+GP + + + L K A++ P P R P +++V E+
Sbjct: 389 PYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQR 448
Query: 439 -KQQAK-PVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRC 496
+QQ++ VER RKR E +R++E++++ + EKL++L ++ K SP+ R
Sbjct: 449 RRQQSEISAAVERARKRRE--EEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIRE 506
Query: 497 LNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDV---------------MEKAAE 541
+E + + ++ + + R+ + K++ EK E
Sbjct: 507 REREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKE 566
Query: 542 VYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAP 601
+ + + K++ +K + E+EK EEK+ E E +++ + P
Sbjct: 567 LERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEP 626
Query: 602 VNGEATSQKGE-SAEDKEHEEGRDSEEGPR 630
V S + E A HE +S PR
Sbjct: 627 VFTRQDSNRSEKEATPVVHETEPESGSQPR 656
Score = 45.4 bits (106), Expect = 2e-04
Identities = 91/420 (21%), Positives = 156/420 (37%), Gaps = 72/420 (17%)
Query: 55 PKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGS 114
PK L D+ + G PN + F E + + S S P + SD P A P +
Sbjct: 767 PKPLMRRDQME---GSPNSSESF-EHIARSARDHAISLSEPRMLWGSDPY-PHAEPQQAT 821
Query: 115 D--ADEDDED-RGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRAR 171
A E+ ED R A+ TAA + ++ +D R
Sbjct: 822 TPKATEEPEDVRSEAALDQEQITAAYSVEHNQLEAHPKADF-----------------IR 864
Query: 172 KASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSA 231
++S Q +S S E+ +++ S P++K + AP+ + + + PS
Sbjct: 865 ESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKT-LSAPQEERISAVESQ--PSR 921
Query: 232 SDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPR--- 288
S S + KP+ SA +S DS ++P E+P KP+
Sbjct: 922 KRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDS----------KEPIERPEEKPKKEG 971
Query: 289 ----GRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRR--L 342
PKPE+ S S + W R + RRE R + +++ L
Sbjct: 972 FIRSSEGPKPEKVYKSKSE----------TRWGPRPSSNRREEVNDRPVRRSGPIKKPVL 1021
Query: 343 REQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDS--E 400
R+ ++E ++R+ + ++ E ++ + D P + P S +
Sbjct: 1022 RDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQ 1081
Query: 401 PEAE---------LEREAKKSAKKP----QSSSTEPARKPGQKEKRVRPEEKQQAKPVKV 447
PEAE L ++ + +KP + EPA K ++ P K++ +P KV
Sbjct: 1082 PEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKV 1141
Score = 35.4 bits (80), Expect = 0.17
Identities = 65/314 (20%), Positives = 108/314 (34%), Gaps = 28/314 (8%)
Query: 166 VSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRA-----PRRGPL 220
V KR R+ S+ D S + +S S+ K ++ PE K V+ P
Sbjct: 1254 VPKRRRQRGSETDTDSEIHESASDKDSLSKG-KLPKREERPENKKPVKPHSSFKPDNHVR 1312
Query: 221 GGRKKKKAPSASDSDSKADSDGAKPEPVAMARSAS--SSSSSSSSSDSDVSVKKPPRGR- 277
+ + P D D K EP R + S S + P R
Sbjct: 1313 IDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRD 1372
Query: 278 ---KPAEKPLPKPR-GRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRR 333
P + +PKP G P+ ++D + +R + R+ RR+ R+
Sbjct: 1373 NQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKRPPKFERKFD-PARERPRRQRPTRPPRQ 1431
Query: 334 EQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGP 393
++ RRLRE+E K E + ++G EPV G + P
Sbjct: 1432 DKPPRFRRLREREAASKSN----------EVVAVPTNGTVNNVAQEPVNTLGDISGNKTP 1481
Query: 394 P-SSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRK 452
S+ +S +A E E + +K + + + P K E ++
Sbjct: 1482 DLSNQNSSDQANEEWETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPKREIAKR 1541
Query: 453 RSEGFSMDRKVEKK 466
FS R V+++
Sbjct: 1542 ---SFSSQRPVDRQ 1552
Score = 33.5 bits (75), Expect = 0.65
Identities = 44/221 (19%), Positives = 88/221 (39%), Gaps = 34/221 (15%)
Query: 275 RGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRRE 334
RG + + P+ R KP+ E PS + E R E+ E+ +RRR+
Sbjct: 1209 RGGRGHTRDYPQYRDNKPRAEHIPSGPLRQREESET--------RSESSDFEVVPKRRRQ 1260
Query: 335 QEEEL-------RRLREQEKEEKERRRERADRGEAER----GSGGSSGDELREDDEPVKK 383
+ E +++ K + +R +R E ++ S + +R D+ ++K
Sbjct: 1261 RGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVKPHSSFKPDNHVRIDNRLLEK 1320
Query: 384 RGRKGRGRGPPSSSDSEPEAELEREA-----KKSAKKPQSSSTEPA--RKPGQKEKRVRP 436
+ + P P+ E R ++ + P + P+ R+P ++ + P
Sbjct: 1321 PYVRDDDKAKPGFL---PKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNP 1377
Query: 437 EEKQQAKPVKVERTRKRSE--GFSMDR---KVEKKKEPSVE 472
+ + KP E R+ + + D+ K E+K +P+ E
Sbjct: 1378 RQSEVPKPEDGEPPRRHEQFIPIAADKRPPKFERKFDPARE 1418
Score = 33.1 bits (74), Expect = 0.85
Identities = 33/152 (21%), Positives = 60/152 (39%), Gaps = 17/152 (11%)
Query: 335 QEEELRRLREQEKEEKE-----RRRERADRGEAERGSGG--------SSGDELREDDEPV 381
QEE + + Q ++ ++ D +E +G S + + +E
Sbjct: 908 QEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKP 967
Query: 382 KKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEK---RVRPEE 438
KK G GP + ++E + S+ + + + P R+ G +K R EE
Sbjct: 968 KKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEE 1027
Query: 439 KQQAKPVKVERTRKRSEGFSM-DRKVEKKKEP 469
++Q K + E+ K +E + K EKK P
Sbjct: 1028 REQRKEKEGEKAEKVTEKVVVKPEKTEKKDLP 1059
Score = 30.8 bits (68), Expect = 4.2
Identities = 38/180 (21%), Positives = 66/180 (36%), Gaps = 35/180 (19%)
Query: 222 GRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAE 281
G ++ P A+ KA++ G P + + + +S + + + + PP KP
Sbjct: 49 GISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKTPEVPPAQPKPGV 108
Query: 282 KPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQE-EELR 340
P+ P S +S+ + D I + + +QE L+
Sbjct: 109 -------AAPPEVAPAPKSWASNKQGGQGDGI--------------QVNSQFQQEFPSLQ 147
Query: 341 RLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSE 400
+QEK+EKE + G LR + + G G+ G PSSSD +
Sbjct: 148 AAGDQEKKEKETNDDNY-----------GPGPSLRPPNVACWRDG--GKAAGSPSSSDQD 194
Score = 30.0 bits (66), Expect = 7.2
Identities = 28/132 (21%), Positives = 50/132 (37%), Gaps = 7/132 (5%)
Query: 163 KMSVSKRARKASSDLDQ--ASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPL 220
K + +++ R +S L A + + ++SS+ + P A+V A PL
Sbjct: 1711 KKNANEKGRSQTSKLPPRFAKKQATGIQQAQSSASVPPLASAPLPPSTSASVPASTSAPL 1770
Query: 221 GGR-----KKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPR 275
AP + + + + + P P + S+S+S S+S + S
Sbjct: 1771 PATLTPVPASTSAPVPASTLAPVLASTSAPVPASPLAPVSASASVSASVPASTSAAAITS 1830
Query: 276 GRKPAEKPLPKP 287
PA P P P
Sbjct: 1831 SSAPASAPAPTP 1842
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 75.5 bits (184), Expect = 2e-13
Identities = 85/305 (27%), Positives = 123/305 (40%), Gaps = 33/305 (10%)
Query: 181 SVSPSEEENSESSSESEKTSDQ--DFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKA 238
S +PS+E + S S K D +P K++ R G K++ S S S +KA
Sbjct: 356 SRNPSKERSHSHSRSSSKERDHRGSSSPRKESG-----RSQSGSPNKQRDHSRSRSPNKA 410
Query: 239 DSDGAKPEPV-AMARSASSSSSSS---SSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKP 294
P A RS S S + + S S S + R R P K R R P
Sbjct: 411 RDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSP-NKARDHSRSRSPNK 469
Query: 295 ERPPSSSSSDSDSDEVDRI-SEWKRRDEARRR----ELEARRRRE--QEEELRRLREQEK 347
R S S S S + ++ S K RD R R E + R+ R +E + RR R K
Sbjct: 470 ARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSK 529
Query: 348 EEKERRRERADRGEAERGSGGSSGDEL--REDDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
E ++RR+ R+ E +R S +E R+ P K+R R+ R R P
Sbjct: 530 E-RQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRR-RWRSPSK---------- 577
Query: 406 EREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEK 465
ERE ++S + +R P ++ RP + K RT + S R K
Sbjct: 578 ERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSK 637
Query: 466 KKEPS 470
+ +PS
Sbjct: 638 ESDPS 642
Score = 65.9 bits (159), Expect = 1e-10
Identities = 91/377 (24%), Positives = 147/377 (38%), Gaps = 26/377 (6%)
Query: 133 ATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSES 192
+T + + S S S + S + KR ++ KR + + + +S+S
Sbjct: 273 STRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQS 332
Query: 193 SSESE-KTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKA-DSDGAKPEPVAM 250
S S+ K+ +Q TP + + R K+++ S S S SK D G+
Sbjct: 333 RSHSKGKSQNQSRTPRRGRSHNWSRNP-----SKERSHSHSRSSSKERDHRGSSSPRKES 387
Query: 251 ARSASSSSSSS---SSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDS 307
RS S S + S S S + R R P K + R R P R S S S +
Sbjct: 388 GRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPY-KARDRSRSRSPNKARDCSRSRSPYKA 446
Query: 308 DEVDRI-SEWKRRDEARRRELEARRRREQEEELRRLREQEK-----EEKERRRERADRGE 361
+ R S K RD +R R R R + + R+ + +E++ RR R+ E
Sbjct: 447 RDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKE 506
Query: 362 AERGSGGSSGDEL--REDDEPVKKRGRKGRGRGPPSSSD---SEPEAELEREAKKSAKKP 416
+ SS E R P K+R R+ + R P D S +E ERE ++S
Sbjct: 507 RQCRQSRSSSKERDHRRSRSPSKERQRR-QSRSPNKERDRSQSRSPSE-EREHRQSRSPS 564
Query: 417 QSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQ 476
+ R P ++ +R + + + R+ + G+S R K+K S
Sbjct: 565 KERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPS 624
Query: 477 K--LHSEIKFALKVDSP 491
K HS+ + + K P
Sbjct: 625 KEGNHSQSRTSSKESDP 641
Score = 59.7 bits (143), Expect = 9e-09
Identities = 110/546 (20%), Positives = 190/546 (34%), Gaps = 44/546 (8%)
Query: 91 SYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSS 150
SY P + S++ N + S G + AVT + A + + S + S
Sbjct: 172 SYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKS 231
Query: 151 DNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKA 210
DN +P+ V + ++ S SP+E + S T + P+ +
Sbjct: 232 DNP-----SPSSSRKVKSYGQMIIPSREK-SYSPTEMSSRVKSYNQASTRSR---PQSHS 282
Query: 211 AVRAPRRGPLGGRKKKKAPSASDS----DSKADSDGAKPEPVAMARSASSSSSSSSSSDS 266
R+PRR G +K+ + S S S+A S K M R + S S S S +
Sbjct: 283 QSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQN 342
Query: 267 DVSVKKPPRGR-----KPAEKPLPKPRGRKPKPERPPSSSSSD-SDSDEVDRISEWKRRD 320
+ P RGR + K R ER SSS +S S K+RD
Sbjct: 343 QS--RTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRD 400
Query: 321 EARRRELEARRRREQEEELRRLREQEKEEKERRRERADRG----EAERGSGGSSGDELRE 376
+R R R R + + R++ + + R +A S S ++ R+
Sbjct: 401 HSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARD 460
Query: 377 DDE---PVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKR 433
P K R R R R P D +E + ++ +S S E + + +
Sbjct: 461 HSRSRSPNKARDRS-RSRSPSKERDHSQLGSPSKE--RDHRRSRSPSKERQCRQSRSSSK 517
Query: 434 VRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDV 493
R + ++ + +R + RS DR + E + + S+ + + SP
Sbjct: 518 ERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSK 577
Query: 494 KR----CLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSR 549
+R ++ EE + S Q K + + ++ ++ +R S+
Sbjct: 578 ERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSK 637
Query: 550 VLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQ 609
P V + + L+ P + + PST P G+ SQ
Sbjct: 638 ESDPSQSTVPR------SPDWKRSPTRTSSLSQNRTPSKTSSHSPST---FPSGGQTLSQ 688
Query: 610 KGESAE 615
A+
Sbjct: 689 DDSQAD 694
Score = 59.3 bits (142), Expect = 1e-08
Identities = 108/617 (17%), Positives = 216/617 (35%), Gaps = 60/617 (9%)
Query: 86 NNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSD 145
++P S ++ S S P A+P A + V A+ R S
Sbjct: 2 SSPKRSSKPSMSLAPSGSSMPTADPKP--PASLKSTKSATPNRSLVPTKPATSRNSVMSP 59
Query: 146 SDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFT 205
S S S ++ P+ + S R R + +PS +S++ K SD
Sbjct: 60 SSSKSTKSTSTKRAPSNRPSSRSRVRSKAR-------TPSRVSTDTRTSKASKASDVRCH 112
Query: 206 PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSS-------- 257
+ R G G R K++PS + + + + GA+P + R+ +S
Sbjct: 113 QRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKS 172
Query: 258 -----SSSSSSSDS---DVSVK--KPPRGR---KPAEKPLPKPRGRKPKPERPPSSSSSD 304
+S+ SDS ++S K +PP G + +E + + P PS SD
Sbjct: 173 YGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSD 232
Query: 305 SDSDEVDR-ISEW------KRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERA 357
+ S R + + R E+ +R + + R + + + RR R+
Sbjct: 233 NPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRS 292
Query: 358 DRGEAERGSGGSSGDELREDDEPVKKRGRKG----RGRGPPSSSDSEPEAELEREAKKSA 413
G +R + + + R RKG GR S S S+ +++ + +
Sbjct: 293 --GSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRG 350
Query: 414 KKPQSSSTEPARKPGQKEKRVRPEEKQQ--AKPVKVERTRKRSEGFSMDRKVEKKKEPSV 471
+ + S P+++ R +E+ + + E R +S + R + + P+
Sbjct: 351 RS-HNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNK 409
Query: 472 EEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKA 531
+ S K + S + + + + ++ + + R
Sbjct: 410 ARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNK 469
Query: 532 NKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAE 591
+D + R S++ P E + +++ ++ + + + + + ++
Sbjct: 470 ARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSK 529
Query: 592 DKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPG 651
++ +P SQ +E++EH + R S D R R
Sbjct: 530 ERQRRQSRSPNKERDRSQSRSPSEEREHRQSR---------SPSKERDRRRW-----RSP 575
Query: 652 SDRQERERARGDSEALD 668
S +ER ++R SE D
Sbjct: 576 SKERERRQSRSSSEERD 592
Score = 31.6 bits (70), Expect = 2.5
Identities = 48/245 (19%), Positives = 80/245 (32%), Gaps = 10/245 (4%)
Query: 71 PNKRKGFNEGLWEIQNNPHASYSAPPPV-----SSSDSEAPEANPADGSDADEDDEDRGV 125
PNK + + + H+ +P S S S+ + + S + D
Sbjct: 467 PNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRS 526
Query: 126 MAVTAVTATAASDRMESDSDSDKS-SDNSGLKRKTPALKMSVSKRARKASSDLDQASVSP 184
+ + S E D +S S+ ++ K +R R S + ++
Sbjct: 527 PSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRS 586
Query: 185 SEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAK 244
S EE S S S P + +A R ++ + S + S S
Sbjct: 587 SSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTV 646
Query: 245 PEPVAMARSASSSSS-SSSSSDSDVSVKKP---PRGRKPAEKPLPKPRGRKPKPERPPSS 300
P RS + +SS S + + S S P P G + + + K P
Sbjct: 647 PRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGER 706
Query: 301 SSSDS 305
SSS S
Sbjct: 707 SSSSS 711
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 74.3 bits (181), Expect = 3e-13
Identities = 65/236 (27%), Positives = 106/236 (44%), Gaps = 35/236 (14%)
Query: 283 PLPKPRGRKPKPERPPS----SSSSDSDSD----EVDRISEW--KRRDEARRRELEARRR 332
PL RGR E P S + D+D D E DR+ E K RD R+R+ E RR+
Sbjct: 46 PLDFSRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRK 105
Query: 333 ---------REQEEELRRLREQEKE---------------EKERRRERADRGEAERGSGG 368
RE++ E+ R RE+EK+ +++R +ER + E +R
Sbjct: 106 EKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQR 165
Query: 369 SSGDELREDDEPVKKRGRKG-RGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKP 427
+ E D E K++ R+ R R ++ E E + +RE + K E R+
Sbjct: 166 ETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREG 225
Query: 428 GQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIK 483
++ R R ++ + + + +R R R E +RK E+KKE ++K +K + K
Sbjct: 226 ERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKK 281
Score = 69.3 bits (168), Expect = 1e-11
Identities = 49/218 (22%), Positives = 100/218 (45%), Gaps = 10/218 (4%)
Query: 264 SDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEAR 323
+D D ++ R R+ EK + R R + R ++ + D ++ I + R++ +
Sbjct: 72 ADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQK 131
Query: 324 RRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKK 383
RE E R RE+E R++++E++ R+ DR D RE + +
Sbjct: 132 GRERERDRGRERE------RDRDREKERERQTEKDRDGQRETETERERDREREKQKERET 185
Query: 384 RGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRP----EEK 439
+ R R + + + E +R+ K ++ + + E R+ ++ +R R +E+
Sbjct: 186 ERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKER 245
Query: 440 QQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQK 477
+ + K ER ++R + +RK +KK+E E+K +K
Sbjct: 246 DRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRK 283
Score = 62.8 bits (151), Expect = 1e-09
Identities = 65/257 (25%), Positives = 103/257 (40%), Gaps = 33/257 (12%)
Query: 217 RGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRG 276
RG LG ++ ++ + AD D + E + D + R
Sbjct: 51 RGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRE-------RR 103
Query: 277 RKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKR---RDEARRRELEARR-- 331
RK E + R ++ + ER E DR E +R R++ R R+ E R
Sbjct: 104 RKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDG 163
Query: 332 RREQEEELRRLREQEKE-----EKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGR 386
+RE E E R RE+EK+ E++R R+R E ER + + + E ++ R
Sbjct: 164 QRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDR 223
Query: 387 KG-----RGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQ 441
+G R R D E + ER+ K+ KK + + RK +KE++ R ++K
Sbjct: 224 EGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKK-- 281
Query: 442 AKPVKVERTRKRSEGFS 458
RK EG S
Sbjct: 282 ---------RKWGEGIS 289
Score = 56.6 bits (135), Expect = 7e-08
Identities = 54/266 (20%), Positives = 107/266 (40%), Gaps = 30/266 (11%)
Query: 176 DLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSD 235
D + + E S ++ K +D D ++ VR +K D D
Sbjct: 48 DFSRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVR------------EKTEKERDRD 95
Query: 236 SKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE 295
K D + + E R+ + D + +K + + + R R+ + E
Sbjct: 96 RKRDRERRRKEKETN-RNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERE 154
Query: 296 RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRE 355
R E +R + + R++ + RE E R R+++ E R R+ ++E ++R+R+
Sbjct: 155 RQTEKDRDGQRETETERERD-REREKQKERETERDRDRQRDTEKERERQTDRE-RDRQRK 212
Query: 356 RADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKK 415
+ E G RE D +++ + RG+ E + ER+ K+ KK
Sbjct: 213 TQTERQRETDREGE-----RETDRRRERQRDRDRGK----------ERDRERDRKEERKK 257
Query: 416 PQSSSTEPARKPGQKEKRVRPEEKQQ 441
+ + RK +KE++ R ++K++
Sbjct: 258 ERKKERKKERKEKKKEEKRREDKKRK 283
Score = 53.9 bits (128), Expect = 5e-07
Identities = 45/221 (20%), Positives = 88/221 (39%), Gaps = 6/221 (2%)
Query: 148 KSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPE 207
K +D +R+ ++ K R D+ +E N E + ++D E
Sbjct: 70 KDADGDDRQRERDRVREKTEKE-RDRDRKRDRERRRKEKETNRNRDREKQTEIERDRERE 128
Query: 208 KKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSD 267
K+ R + + + ++ D DG + R ++ D
Sbjct: 129 KQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERD 188
Query: 268 VSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSD-EVDRISEWKRRDEARRRE 326
++ + + + R RK + ER +D + + E DR E ++RD R +E
Sbjct: 189 RDRQRDTEKERERQTDRERDRQRKTQTER---QRETDREGERETDRRRE-RQRDRDRGKE 244
Query: 327 LEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSG 367
+ R R++E + R +E++KE KE+++E R + +R G
Sbjct: 245 RDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKWG 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.302 0.123 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,430,104
Number of Sequences: 37866
Number of extensions: 1777159
Number of successful extensions: 41794
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 875
Number of HSP's successfully gapped in prelim test: 2002
Number of HSP's that attempted gapping in prelim test: 13187
Number of HSP's gapped (non-prelim): 13618
length of query: 671
length of database: 18,247,518
effective HSP length: 109
effective length of query: 562
effective length of database: 14,120,124
effective search space: 7935509688
effective search space used: 7935509688
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.