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Search of human proteins with 47717123
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
(1721 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 3445 0.0
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 2434 0.0
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 1966 0.0
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 1951 0.0
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 1216 0.0
gi|10864047 epidermal growth factor receptor pathway substrate 1... 176 2e-43
gi|148746195 trichohyalin [Homo sapiens] 132 3e-30
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 122 3e-27
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 122 3e-27
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 122 4e-27
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 122 4e-27
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 122 4e-27
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 122 4e-27
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 122 4e-27
gi|4503593 epidermal growth factor receptor pathway substrate 15... 120 9e-27
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 119 2e-26
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 115 3e-25
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 115 3e-25
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 115 3e-25
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 115 4e-25
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 115 5e-25
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 114 8e-25
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 114 1e-24
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 112 4e-24
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 111 7e-24
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 111 7e-24
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 111 7e-24
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 111 7e-24
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 111 7e-24
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 108 3e-23
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 3445 bits (8934), Expect = 0.0
Identities = 1721/1721 (100%), Positives = 1721/1721 (100%)
Query: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ
Sbjct: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
Query: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGI 120
IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGI
Sbjct: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGI 120
Query: 121 ASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLP 180
ASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLP
Sbjct: 121 ASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLP 180
Query: 181 KSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHL 240
KSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHL
Sbjct: 181 KSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHL 240
Query: 241 TGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLP 300
TGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLP
Sbjct: 241 TGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLP 300
Query: 301 PEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFER 360
PEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFER
Sbjct: 301 PEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFER 360
Query: 361 GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE 420
GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE
Sbjct: 361 GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE 420
Query: 421 RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEF 480
RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEF
Sbjct: 421 RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEF 480
Query: 481 ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR 540
ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR
Sbjct: 481 ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR 540
Query: 541 LIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEI 600
LIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEI
Sbjct: 541 LIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEI 600
Query: 601 DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQW 660
DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQW
Sbjct: 601 DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQW 660
Query: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
Query: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG
Sbjct: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
Query: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS
Sbjct: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
Query: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG
Sbjct: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
Query: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
Query: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGD 1020
FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGD
Sbjct: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGD 1020
Query: 1021 LTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ 1080
LTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ
Sbjct: 1021 LTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ 1080
Query: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT 1140
VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT
Sbjct: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT 1140
Query: 1141 SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ 1200
SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ
Sbjct: 1141 SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ 1200
Query: 1201 VGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVT 1260
VGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVT
Sbjct: 1201 VGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVT 1260
Query: 1261 EIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILS 1320
EIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILS
Sbjct: 1261 EIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILS 1320
Query: 1321 AQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQ 1380
AQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQ
Sbjct: 1321 AQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQ 1380
Query: 1381 RVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHV 1440
RVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHV
Sbjct: 1381 RVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHV 1440
Query: 1441 QCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSG 1500
QCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSG
Sbjct: 1441 QCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSG 1500
Query: 1501 TDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERT 1560
TDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERT
Sbjct: 1501 TDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERT 1560
Query: 1561 AWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPY 1620
AWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPY
Sbjct: 1561 AWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPY 1620
Query: 1621 CEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEI 1680
CEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEI
Sbjct: 1621 CEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEI 1680
Query: 1681 RVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP 1721
RVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP
Sbjct: 1681 RVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP 1721
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 2434 bits (6309), Expect = 0.0
Identities = 1220/1220 (100%), Positives = 1220/1220 (100%)
Query: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ
Sbjct: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
Query: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGI 120
IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGI
Sbjct: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGI 120
Query: 121 ASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLP 180
ASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLP
Sbjct: 121 ASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLP 180
Query: 181 KSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHL 240
KSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHL
Sbjct: 181 KSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHL 240
Query: 241 TGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLP 300
TGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLP
Sbjct: 241 TGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLP 300
Query: 301 PEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFER 360
PEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFER
Sbjct: 301 PEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFER 360
Query: 361 GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE 420
GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE
Sbjct: 361 GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE 420
Query: 421 RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEF 480
RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEF
Sbjct: 421 RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEF 480
Query: 481 ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR 540
ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR
Sbjct: 481 ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR 540
Query: 541 LIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEI 600
LIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEI
Sbjct: 541 LIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEI 600
Query: 601 DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQW 660
DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQW
Sbjct: 601 DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQW 660
Query: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
Query: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG
Sbjct: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
Query: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS
Sbjct: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
Query: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG
Sbjct: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
Query: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
Query: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGD 1020
FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGD
Sbjct: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGD 1020
Query: 1021 LTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ 1080
LTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ
Sbjct: 1021 LTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ 1080
Query: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT 1140
VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT
Sbjct: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT 1140
Query: 1141 SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ 1200
SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ
Sbjct: 1141 SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ 1200
Query: 1201 VGLFPSNYVKLTTDMDPSQQ 1220
VGLFPSNYVKLTTDMDPSQQ
Sbjct: 1201 VGLFPSNYVKLTTDMDPSQQ 1220
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 1966 bits (5093), Expect = 0.0
Identities = 1049/1756 (59%), Positives = 1296/1756 (73%), Gaps = 127/1756 (7%)
Query: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
Query: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
Query: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
Query: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
Query: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
Query: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
Query: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
Query: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
Query: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP-DSGVSLLHKKS 585
Query: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLK 631
LE +EL Q L++QLD +EKET SKL E+D FNNQLKELRE +N QQL ++ + +R K
Sbjct: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDK 644
Query: 632 QKEQERKIIELEKQK---EEAQRRAQE-RDKQWLEHVQQEDEHQRPRKLHEEEKLKREES 687
KE ERK +EL ++K +EA R+A++ ++ W E++++E+E E++K +EE
Sbjct: 645 LKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE--------EKQKRLQEEK 696
Query: 688 VKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRA 747
++K EE+ K E + Q K ++A EK T S +V YRA
Sbjct: 697 TQEKIQEEERKAE----------EKQRKDKDTLKAE----EKKRETASV-----LVNYRA 737
Query: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
LYPFE+R+HDE++ GDI+ V DE GEPGWL G +G GWFP NY EK+P +
Sbjct: 738 LYPFEARNHDEMSFNSGDIIQV-----DEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSS 792
Query: 808 EVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPET 867
E + A +PK AL L+ TS+ S+ P S+N+
Sbjct: 793 E----------NEKAVSPKKALLPPTVSLSATST-------------SSEPLSSNQPASV 829
Query: 868 DNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAK 927
++ + +LTV ++ Q ++SAFT + GS SP+ GQG+ VE L+AQAL W AK
Sbjct: 830 TDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPGSV-SPIHGQGQVVENLKAQALCSWTAK 885
Query: 928 KDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESP 987
KDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GWFPKSYVK+I G K E P
Sbjct: 886 KDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKR--------EEP 937
Query: 988 ASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGD 1045
+L + P + GEE+IA+Y Y S E GDLTF +G+ ILVT+KDG+WWTG++GD
Sbjct: 938 EALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGD 997
Query: 1046 KAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRK 1105
++G+FPSNYV+ KD E G+A K+G+ KKPEIAQV ++Y A+G EQL+LAPGQLILI K
Sbjct: 998 RSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILK 1057
Query: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYD 1165
KN GWW+GELQARGKKRQ GWFPA++VKLL P + + TP P VCQVI MYD
Sbjct: 1058 KNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQVIAMYD 1110
Query: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDL 1225
Y A N+DEL+F+KGQ+INV+NK+DPDWW+GE+NG GLFPSNYVK+TTD DPSQQWC+DL
Sbjct: 1111 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADL 1170
Query: 1226 HLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNW 1285
LD + P ERKRQGYIHELI TEE Y+ DLQLV E+FQK + ES LTE E+A+IFVNW
Sbjct: 1171 QTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNW 1230
Query: 1286 KELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQ 1345
KELIM N KLLKALRVRKK GEKMPV+MIGDIL+A+L HMQ YIRFCS QLNGAAL+QQ
Sbjct: 1231 KELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQ 1290
Query: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
KTDE DFKEF+K+LA DPRCKGMPLSSF+LKPMQR+TRYPL+I++ILENTPE+H DHS
Sbjct: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
Query: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLH 1465
LK ALE+AEELCSQVNEGVREKENSDRLEWIQAHVQCEGL+EQL+FNS+TNCLGPRK LH
Sbjct: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLH 1410
Query: 1466 SGKLYKAKSNKELYGFLFNDFLLLTQITKPLG-SSGTDKVFSPKSNLQYKMYKTPIFLNE 1524
SGKLYK KSNKEL+GFLFNDFLLLT + K SSG++K+FS KSN Q+KMYKTPIFLNE
Sbjct: 1411 SGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNE 1470
Query: 1525 VLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKA 1584
VLVKLPTDPS DEP+FHISHIDRVYTLR ++INERTAWVQKIKAASE YI+TEKKKREKA
Sbjct: 1471 VLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKA 1530
Query: 1585 YLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWN 1644
Y RSQ+ +GIGRLMV+V+E ELK C+ +GKSNPYCE++MGSQ + T+TIQDTLNPKWN
Sbjct: 1531 YQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWN 1590
Query: 1645 SNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEV 1704
NCQFFI+DL Q+VLC+T+F+RDQFSPDDFLGRTEI VA I+ +Q SKGP+T+ LLLHEV
Sbjct: 1591 FNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEV 1650
Query: 1705 PTGEIVVRLDLQLFDE 1720
PTGE+ VR DLQLF++
Sbjct: 1651 PTGEVWVRFDLQLFEQ 1666
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 1951 bits (5055), Expect = 0.0
Identities = 1049/1783 (58%), Positives = 1296/1783 (72%), Gaps = 154/1783 (8%)
Query: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
Query: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
Query: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
Query: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
Query: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
Query: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
Query: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
Query: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
Query: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP-DSGVSLLHKKS 585
Query: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLK----------------------- 608
LE +EL Q L++QLD +EKET SKL E+D FNNQLK
Sbjct: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF 644
Query: 609 ----ELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQK---EEAQRRAQE-RDKQW 660
ELRE +N QQL ++ + +R K KE ERK +EL ++K +EA R+A++ ++ W
Sbjct: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
Query: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
E++++E+E E++K +EE ++K EE+ K E + Q K +
Sbjct: 705 KENLRKEEE--------EKQKRLQEEKTQEKIQEEERKAE----------EKQRKDKDTL 746
Query: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
+A EK T S +V YRALYPFE+R+HDE++ GDI+ V DE G
Sbjct: 747 KAE----EKKRETASV-----LVNYRALYPFEARNHDEMSFNSGDIIQV-----DEKTVG 792
Query: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
EPGWL G +G GWFP NY EK+P +E + A +PK AL L+ TS
Sbjct: 793 EPGWLYGSFQGNFGWFPCNYVEKMPSSE----------NEKAVSPKKALLPPTVSLSATS 842
Query: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
+ S+ P S+N+ ++ + +LTV ++ Q ++SAFT + G
Sbjct: 843 T-------------SSEPLSSNQPASVTDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPG 886
Query: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
S SP+ GQG+ VE L+AQAL W AKKDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GW
Sbjct: 887 SV-SPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGW 945
Query: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQ 1018
FPKSYVK+I G K E P +L + P + GEE+IA+Y Y S E
Sbjct: 946 FPKSYVKIIPGSEVKR--------EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEP 997
Query: 1019 GDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI 1078
GDLTF +G+ ILVT+KDG+WWTG++GD++G+FPSNYV+ KD E G+A K+G+ KKPEI
Sbjct: 998 GDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEI 1057
Query: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
AQV ++Y A+G EQL+LAPGQLILI KKN GWW+GELQARGKKRQ GWFPA++VKLL P
Sbjct: 1058 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117
Query: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
+ + TP P VCQVI MYDY A N+DEL+F+KGQ+INV+NK+DPDWW+GE+N
Sbjct: 1118 SSERATPAFHP-------VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN 1170
Query: 1199 GQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQL 1258
G GLFPSNYVK+TTD DPSQQWC+DL LD + P ERKRQGYIHELI TEE Y+ DLQL
Sbjct: 1171 GVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQL 1230
Query: 1259 VTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDI 1318
V E+FQK + ES LTE E+A+IFVNWKELIM N KLLKALRVRKK GEKMPV+MIGDI
Sbjct: 1231 VVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDI 1290
Query: 1319 LSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKP 1378
L+A+L HMQ YIRFCS QLNGAAL+QQKTDE DFKEF+K+LA DPRCKGMPLSSF+LKP
Sbjct: 1291 LAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKP 1350
Query: 1379 MQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQA 1438
MQR+TRYPL+I++ILENTPE+H DHS LK ALE+AEELCSQVNEGVREKENSDRLEWIQA
Sbjct: 1351 MQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQA 1410
Query: 1439 HVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLG- 1497
HVQCEGL+EQL+FNS+TNCLGPRK LHSGKLYK KSNKEL+GFLFNDFLLLT + K
Sbjct: 1411 HVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAV 1470
Query: 1498 SSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESIN 1557
SSG++K+FS KSN Q+KMYKTPIFLNEVLVKLPTDPS DEP+FHISHIDRVYTLR ++IN
Sbjct: 1471 SSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNIN 1530
Query: 1558 ERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKS 1617
ERTAWVQKIKAASE YI+TEKKKREKAY RSQ+ +GIGRLMV+V+E ELK C+ +GKS
Sbjct: 1531 ERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKS 1590
Query: 1618 NPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGR 1677
NPYCE++MGSQ + T+TIQDTLNPKWN NCQFFI+DL Q+VLC+T+F+RDQFSPDDFLGR
Sbjct: 1591 NPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGR 1650
Query: 1678 TEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDE 1720
TEI VA I+ +Q SKGP+T+ LLLHEVPTGE+ VR DLQLF++
Sbjct: 1651 TEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQ 1693
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 1216 bits (3147), Expect = 0.0
Identities = 691/1324 (52%), Positives = 885/1324 (66%), Gaps = 153/1324 (11%)
Query: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
Query: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
Query: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
Query: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
Query: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
Query: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
Query: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
Query: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
Query: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNT-PDSGVSLLHKKS 585
Query: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQ------------------------- 606
LE +EL Q L++QLD +EKET SKL E+D FNNQ
Sbjct: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF 644
Query: 607 --LKELREIHNKQQLQKQKSMEAERLKQKEQERKIIEL---EKQKEEAQRRA-QERDKQW 660
LKELRE +N QQL ++ + +R K KE ERK +EL +K ++EA R+A Q ++ W
Sbjct: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
Query: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
E++++E+E E++K +EE ++K EE+ K E + Q K +
Sbjct: 705 KENLRKEEE--------EKQKRLQEEKTQEKIQEEERKAE----------EKQRKDKDTL 746
Query: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
+A EK T S +V YRALYPFE+R+HDE++ GDI+ VDE G
Sbjct: 747 KA----EEKKRETASV-----LVNYRALYPFEARNHDEMSFNSGDIIQ-----VDEKTVG 792
Query: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
EPGWL G +G GWFP NY EK+P +E + A +PK AL L+ TS
Sbjct: 793 EPGWLYGSFQGNFGWFPCNYVEKMPSSE----------NEKAVSPKKALLPPTVSLSATS 842
Query: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
+S+ P S+N+ ++ + +LTV ++ Q ++SAFT + G
Sbjct: 843 -------------TSSEPLSSNQPASVTDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPG 886
Query: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
S SP+ GQG+ VE L+AQAL W AKKDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GW
Sbjct: 887 -SVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGW 945
Query: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQ 1018
FPKSYVK+I G K E P +L + P + GEE+IA+Y Y S E
Sbjct: 946 FPKSYVKIIPGSEVK--------REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEP 997
Query: 1019 GDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI 1078
GDLTF +G+ ILVT+KDG+WWTG++GD++G+FPSNYV+ KD E G+A K+G+ KKPEI
Sbjct: 998 GDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEI 1057
Query: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
AQV ++Y A+G EQL+LAPGQLILI KKN GWW+GELQARGKKRQ GWFPA++VKLL P
Sbjct: 1058 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117
Query: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
+ + TP P VCQVI MYDY A N+DEL+F+KGQ+INV+NK+DPDWW+GE+N
Sbjct: 1118 SSERATPAFHP-------VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN 1170
Query: 1199 GQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQL 1258
G GLFPSNYVK+TTD DPSQQWC+DL LD + P ERKRQGYIHELI TEE Y+ DLQL
Sbjct: 1171 GVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQL 1230
Query: 1259 VTEI 1262
V E+
Sbjct: 1231 VVEV 1234
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 176 bits (445), Expect = 2e-43
Identities = 147/601 (24%), Positives = 258/601 (42%), Gaps = 111/601 (18%)
Query: 15 WAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMD 74
WA+ VEE+AK D F SL PI+G ++GD+ + S LP VL ++W L+D++ DG +D
Sbjct: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
Query: 75 QVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPM 134
+ EF++AM L+ L+ +PSALPP + +PP V
Sbjct: 181 RDEFAVAMHLVYRALEKEPVPSALPPSL--------------------IPPSKRKKTVFP 220
Query: 135 GSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGS-- 192
G++PV+ PA+ PK S S GS
Sbjct: 221 GAVPVL----------------------------------PASPPPKDSLRSTPSHGSVS 246
Query: 193 QLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQS 252
LN+ + + P W VP + ++++ ++F D + G+++G + + I M S
Sbjct: 247 SLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHS 306
Query: 253 SLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMS-GQPLPPVLPPEYIPPSFRRV 311
L Q LA IW L+D Q GKL+ ++F LAM+ I +S G P VL P+ +PPS R
Sbjct: 307 GLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT 366
Query: 312 RSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQA 371
+ S G EL+ Q
Sbjct: 367 PGPDSSGSLGSGEF----------------------------------TGVKELDDISQE 392
Query: 372 LLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEI 431
+ + QR++ + E+ +++ + QE + L+ E ++ E ++Q ++R E+
Sbjct: 393 IAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEM 452
Query: 432 ERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQ 491
++++A R++ L R + Q+ E + I LK + ++ E +L++ D ++
Sbjct: 453 DQQKAKLRDM-----LSDVRQKCQD-------ETQMISSLKTQIQSQESDLKSQEDDLNR 500
Query: 492 LEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQ 551
+ +L ++ T Q I++ E I + Q ++ +++ L +L +Q +
Sbjct: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
Query: 552 LKQVQQ--NSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKE 609
L+Q Q + H SL L E LA + +D+ K + +F+N +E
Sbjct: 561 LEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFK------NKALLFSNNTQE 614
Query: 610 L 610
L
Sbjct: 615 L 615
Score = 109 bits (273), Expect = 2e-23
Identities = 109/479 (22%), Positives = 206/479 (43%), Gaps = 74/479 (15%)
Query: 192 SQLNTKLQKAQSFDVAS----VPPVAE--WAVPQSSRLKYRQLFNSHDKTMSGHLTGPQA 245
S LN + + D +S PP AE WAV + K+ +F S ++G L+G +
Sbjct: 92 SNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKV 150
Query: 246 RTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIP 305
+ +LM S LP L +W+LSDID+DG L +EF +AMHL+ A+ +P+P LPP IP
Sbjct: 151 KPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIP 210
Query: 306 PSFRR--------------------VRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKK 345
PS R+ +RS +SS + L + L+ Q +
Sbjct: 211 PSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWV 270
Query: 346 LPVTFEDKKRENFERGNLELE-----KRRQALLEQQRKEQERLAQL-ERAEQERKERERQ 399
+PV + + E F + +L+L+ + + + Q LA + A+ + + +
Sbjct: 271 VPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSK 330
Query: 400 EQERKRQLELEKQLEK------------------------------------QRELERQR 423
+Q +++++ K +EL+
Sbjct: 331 DQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDIS 390
Query: 424 EEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELE 483
+E + + E+ + E++ + + + QEL N ++E + L+A+K+ + L+
Sbjct: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
Query: 484 ALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIP 543
++ +K +L L D+R + + Q I S + + +++ + L ++ L RL
Sbjct: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQ 510
Query: 544 EKQILNDQLKQVQQNSLHRDSLV-TLKRALEAKELARQHLRDQLDEVEKETRSKLQEID 601
E+ L + +Q + ++++ +LK + AR L QL E +E L++ D
Sbjct: 511 EETQLE---QSIQAGRVQLETIIKSLKSTQDEINQARSKL-SQLHESRQEAHRSLEQYD 565
Score = 51.2 bits (121), Expect = 8e-06
Identities = 36/179 (20%), Positives = 86/179 (48%), Gaps = 5/179 (2%)
Query: 481 ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR 540
E+ L +K+ LE +++ + + E++ + + + L+ Q Q++Q L
Sbjct: 392 EIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDE 451
Query: 541 LIPEKQILNDQLKQVQQNSLHRDSLVT-LKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
+ +K L D L V+Q +++ LK ++++E L+ Q D++ + +S+L
Sbjct: 452 MDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQE---SDLKSQEDDLNR-AKSELNR 507
Query: 600 IDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDK 658
+ QL++ + Q KS+++ + + + K+ +L + ++EA R ++ D+
Sbjct: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQ 566
Score = 40.8 bits (94), Expect = 0.011
Identities = 47/191 (24%), Positives = 88/191 (46%), Gaps = 35/191 (18%)
Query: 530 QLQESQQMLGRLIPEKQ-ILNDQLKQVQ--QNSLHRDSLVTLKRALEAKELARQHLRDQL 586
QLQ + L + I EK+ + + +VQ QN L R++ +L+ E +Q +D+L
Sbjct: 395 QLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRET-----SSLQELEAQKQDAQDRL 449
Query: 587 DEVEKETRSKLQEI--DIFNNQLKELREIHN-KQQLQKQKSMEAERLKQKEQERKIIELE 643
DE++++ ++KL+++ D+ E + I + K Q+Q Q+S +L+
Sbjct: 450 DEMDQQ-KAKLRDMLSDVRQKCQDETQMISSLKTQIQSQES----------------DLK 492
Query: 644 KQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQD 703
Q+++ R E ++ E Q E Q R ++ E +K + +A+
Sbjct: 493 SQEDDLNRAKSELNRLQQEETQLEQSIQAGR-------VQLETIIKSLKSTQDEINQARS 545
Query: 704 KLGRLFHQHQE 714
KL +L QE
Sbjct: 546 KLSQLHESRQE 556
Score = 40.0 bits (92), Expect = 0.020
Identities = 32/138 (23%), Positives = 66/138 (47%), Gaps = 7/138 (5%)
Query: 573 EAKELARQH--LRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERL 630
E +L R+ L + E E+ R K E+ N L RE + Q+L+ QK +RL
Sbjct: 392 EIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLD--RETSSLQELEAQKQDAQDRL 449
Query: 631 KQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKK 690
+ +Q++ +L + +++ Q+ + Q + ++ + + Q +E+ L R +S
Sbjct: 450 DEMDQQK--AKLRDMLSDVRQKCQD-ETQMISSLKTQIQSQESDLKSQEDDLNRAKSELN 506
Query: 691 KDGEEKGKQEAQDKLGRL 708
+ +E+ + E + GR+
Sbjct: 507 RLQQEETQLEQSIQAGRV 524
Score = 38.9 bits (89), Expect = 0.044
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 217 VPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTA 276
+P + L Y + D +G + +A L +S L L IW+L+D + G L
Sbjct: 12 IPTGNSL-YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDK 70
Query: 277 EEFILAMHLIDVAMSG 292
+ F +A+ L+ A SG
Sbjct: 71 QGFYVALRLVACAQSG 86
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 132 bits (332), Expect = 3e-30
Identities = 105/408 (25%), Positives = 220/408 (53%), Gaps = 38/408 (9%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQ 385
++R ++ E ++++ E++L E+++ + R + E+RR+ L ++++E+ R Q
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRRE--QEEERREQQLRREQEEERREQQ 376
Query: 386 LERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQR 445
L R +Q R+E Q+ R++QL E+QL ++++L R+++ R +++ R + +RE E +R
Sbjct: 377 LRREQQLRRE---QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 446 -QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDK-KHQLEGKLQDIRCRL 503
+ + E+ RR++ L + +E+ D LK +++T E E + K E + ++ +L
Sbjct: 434 HEQKHEQERREQRLKREQEERRD--WLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491
Query: 504 TTQRQEIESTNKSRELRIAEITHLQQQL---QESQQMLGRLIPEKQILNDQLKQVQQNSL 560
+ + + + ++LR + +Q+L +E +++ RL E+Q+ +Q ++ +Q
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ--- 548
Query: 561 HRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQ 620
LKR E K L ++ +L ++E R +L + + Q + RE + + Q
Sbjct: 549 ------LLKRE-EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE-Q 600
Query: 621 KQKSMEAERLKQKEQERKIIELEKQKEEAQRR------AQERDKQWLEHVQQEDEHQRPR 674
+ K E ERL+Q+E+ + ++ E+ +EE +++ +ER +Q L QQE QR +
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 675 KLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQA 722
+ EEE+L E+ +K++ EE+ +QE L + QE A+ +++
Sbjct: 661 REEEEERL--EQRLKREHEEERREQE-------LAEEEQEQARERIKS 699
Score = 128 bits (322), Expect = 4e-29
Identities = 103/411 (25%), Positives = 212/411 (51%), Gaps = 48/411 (11%)
Query: 336 EDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQ----QRKEQERLAQLERAEQ 391
E++QQQ ++ F++++ + + + L K + L E+ QR+ QE QL + E+
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 392 ERKERERQEQERKRQ-LELEKQLE-KQRELERQREEERRKEIERREAAKRELERQRQLEW 449
+ RERQE+E+++Q L E+QL KQ E R+++EERR++ ERRE + E+Q + E
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ 343
Query: 450 ERNRRQELLNQRNKEQEDIVVLKA-----------KKKTLEFELEALNDKKHQLEGKLQ- 497
E R Q+L ++ +E+ + + + +++ L E + +++ + E +L+
Sbjct: 344 EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR 403
Query: 498 DIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQ 557
+ + R Q + + + ++LR + +Q E ++ RL E++ D LK+ ++
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 558 NSLHRDSL--VTLKR-----------------ALEAKELARQHLRDQLDEVEKETRSKLQ 598
H LKR E +E Q LR + +E ++ + +
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523
Query: 599 EIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQ----RRAQ 654
E + +L+ +++ +Q+ ++++ ++ E K+ EQER+ L++++EE + +R +
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 655 ERDKQWLEHVQQEDEHQRPR-----KLHEEEKLKREESVKKKDGEEKGKQE 700
ER +Q L+ Q+E QR + +L +EE +RE+ +K+++ EE+ +Q+
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEE--RREQRLKREEPEEERRQQ 632
Score = 123 bits (308), Expect = 2e-27
Identities = 116/416 (27%), Positives = 217/416 (52%), Gaps = 42/416 (10%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDK-KRENFERGNLELEKRRQALLEQQRKEQERLA 384
DQ L E E QQ+L+++ E + KRE ER LE E+RR+ L+++ E+ER
Sbjct: 576 DQLLKREE--ERRQQRLKREQEERLEQRLKREEVER--LEQEERREQRLKREEPEEERRQ 631
Query: 385 QLERAEQERKERERQ---EQERKRQLELEKQLEKQR---ELERQREEERRK----EIERR 434
QL ++E++ + R++Q EQ+ +R+ L+++ E++R L+R+ EEERR+ E E+
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 435 EAAKRELER----QRQLEWERNRRQELLNQRNKEQEDI---VVLKAKKKTLEFELEALND 487
+A +R R Q QLE E + RQ + R ++QE + K++ E EL+ +
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 488 KKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIA-----EITHLQQQLQESQQMLGRLI 542
++ + + ++ R T Q Q E + + R+ A E Q + +E QQ R +
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811
Query: 543 PEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQ--HLRDQLDEVEKETRSKLQEI 600
PE++ + +Q ++ L + L+ +E A+Q D L E ++ RS+ Q
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEE-EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Query: 601 DI-FNNQLKELRE-----IHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQ 654
D + QL+E R+ ++ K LQ+Q E + L+++E+E + E EK++ + Q R
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 655 ERDKQWLEHVQQ--EDEHQRPRKLHEEEKLKREESVKKKD----GEEKGKQEAQDK 704
++Q + +Q +E ++ R+ E + ++++ +++K+ GEE K+ Q++
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER 986
Score = 122 bits (306), Expect = 3e-27
Identities = 104/421 (24%), Positives = 221/421 (52%), Gaps = 44/421 (10%)
Query: 332 EPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQ 391
+P L+++ ++ ++ L E+ +RE E+ + ++R+ EQ ++E+E+L + ER ++
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 392 ERKERERQEQERKRQLELEKQL-----EKQRELERQRE--EERRKEIERREAAKRELERQ 444
R+ERERQ ++ K+ + E+QL EK+R ER+++ EE + E + + E E++
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 445 RQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLE------FELEALNDKKHQLEGKLQD 498
R+ EWER R++ ++ +E+E ++ + +K+ L+ E E L ++ QL G+ ++
Sbjct: 1012 RRQEWERQYRKK--DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 499 IRCRLTTQRQEIE-STNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQ 557
T +RQE+E K EL+ E +Q L+E + R E+Q ++ Q ++
Sbjct: 1070 -----TRRRQELERQYRKEEELQQEE----EQLLREEPEKRRRQERERQCREEEELQQEE 1120
Query: 558 NSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQ 617
L R+ +R +EL RQ+ + +EV++E L+E + + +E+ +
Sbjct: 1121 EQLLREEREKRRR----QELERQYREE--EEVQQEEEQLLRE----EPEKRRRQELERQY 1170
Query: 618 QLQKQKSMEAERLKQKEQERKIIELEKQ-KEEAQRRAQERDKQWLEHVQQED-----EHQ 671
+ +++ E E+L ++EQE++ E E+Q +EE + + Q+R +++ + Q+ D E +
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230
Query: 672 RPRKLHEEE---KLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAE 728
+ + + + K + E ++ + + +++Q L L + QE + + W +
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD 1290
Query: 729 K 729
+
Sbjct: 1291 R 1291
Score = 121 bits (304), Expect = 5e-27
Identities = 111/411 (27%), Positives = 209/411 (50%), Gaps = 39/411 (9%)
Query: 325 VDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLA 384
++++ +E L+ E++QL ++ P ++RE R EL++ + LL ++R+++ R
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR-- 1133
Query: 385 QLERAEQERKERERQEQERKRQLELEKQLEKQRELERQ-REEERRKEIE----RREAAKR 439
+ E++ +E E +QE ++ L E + +++ELERQ REEE ++ E R E KR
Sbjct: 1134 --QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191
Query: 440 ELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELE-ALNDKKHQLEGK--- 495
ER+RQ E +++ QR ++++ LK + E E E A+ D K +G+
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ---WEPEKENAVRDNKVYCKGRENE 1248
Query: 496 ----LQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQ 551
L+D + R +Q+++ ++ R E Q + Q R PE++ L
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE------QERRRWQQRDRHFPEEEQLE-- 1300
Query: 552 LKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEID----IFNNQL 607
++ Q+ + RD ++ L +E + R + D +E LQE + +
Sbjct: 1301 -REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Query: 608 KELREIHNKQQLQKQKSMEAE-RLKQKEQERKIIELEKQ---KEEAQRRAQERDKQWLEH 663
++ RE + Q Q +K +E E RL+++E+ERK ++ E+Q +E Q+ Q+RD+++ E
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREE 1419
Query: 664 VQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQE 714
QQ +R RK EEE+ R + ++K EE +Q+ + + R F + ++
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEE--EQQLRQERHRKFREEEQ 1468
Score = 120 bits (302), Expect = 9e-27
Identities = 121/452 (26%), Positives = 223/452 (49%), Gaps = 82/452 (18%)
Query: 327 QRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNL---ELEKRRQALLEQQRKEQERL 383
Q+ E+ + E+ +++ ++L + +++ E L E EKRR+ LE+Q +E+E L
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176
Query: 384 AQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEI------ERREAA 437
Q E + R+E+E++ QER+RQ E++L++Q+ +R R+E++R ++ E+ A
Sbjct: 1177 QQ-EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235
Query: 438 K--------RELERQRQLE--------------------WERNRRQELLNQRNKEQEDIV 469
+ RE E+ RQLE ER+R QE +R +Q D
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE---RRRWQQRDRH 1292
Query: 470 VLKAKKKTLEFELEALN-DKKHQLEGKL-----QDIRCRLTTQR--------------QE 509
+ ++ E + EA D+K Q E +L ++ R R T R Q
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 510 IESTNKSRELRIAEITHLQQ--QLQESQQMLGRLIPEKQILNDQLK---QVQQNSLHRDS 564
+ + R+ R E+ H +Q + E +Q L R E++ L ++ + Q ++ L +D
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 565 LVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQ-- 622
K E ++L+RQ + E E++ R + +E + + +E H K + ++Q
Sbjct: 1413 --DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 623 KSMEAERLKQKEQERKIIELEKQKEEAQR---------RAQERDKQWLEHVQQEDEHQRP 673
+ E ++L ++E++RK +E E+Q +R R+QE ++++LE QQ QR
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 674 RK-LHEEEKLKREE--SVKKKDGEEKGKQEAQ 702
RK L EE++L+R+E +++D + K ++E Q
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562
Score = 119 bits (299), Expect = 2e-26
Identities = 112/421 (26%), Positives = 211/421 (50%), Gaps = 56/421 (13%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQ 385
D+ PEE LE E+Q+ K+ +++K+ E EKRR+ +++ +E+E+L Q
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE---EKRRRQETDRKFREEEQLLQ 1346
Query: 386 LERAEQERKERERQEQERKRQLELEKQLEKQRELE-RQREEERRKEIERREAAKRELERQ 444
ER EQ + +ER + R+ +L ++Q K E E R R +ER ++ + E R ER+
Sbjct: 1347 -EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Query: 445 RQLEWERNR----------RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEG 494
+QL +R+R RQE + +E++ + + ++K LE E + ++ +
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 495 KLQDIRCRLTTQ------------------RQEIESTNKSRELRIAE----ITHLQQQLQ 532
+ Q ++ R Q RQE + + +ELR E +QQL
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 533 ESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKE 592
QQ + + E+Q L Q ++ QQ RD ++ E ++L ++ QL E++
Sbjct: 1526 R-QQRQRKFLQEEQQLRRQ-ERGQQRRQDRD-----RKFREEEQLRQEREEQQLSRQERD 1578
Query: 593 TRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRR 652
+ +L+E + Q +E + + ++QQL++Q+ + R ++ + R+ +L +++EE Q
Sbjct: 1579 RKFRLEEQKV-RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Query: 653 AQERDKQWLEHV--------QQEDEHQRPRKLHEEEKLKR---EESVKKKDGEEKGKQEA 701
QERD+++LE +Q+ H R RK EEE+L + E+ +++++ + K ++E
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 702 Q 702
Q
Sbjct: 1698 Q 1698
Score = 118 bits (296), Expect = 4e-26
Identities = 107/416 (25%), Positives = 201/416 (48%), Gaps = 35/416 (8%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDK-KRENFERGNLELEKRRQALLEQQ-RKEQE-- 381
+Q+L E E +QQL ++ + E + +RE R +L + +Q EQQ R+EQ+
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420
Query: 382 RLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKREL 441
R QL R ++E + ++ EQER+ Q +Q E++ L+R+ E ER ++ R++ KR+
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480
Query: 442 ERQRQLEW------ERNRRQELLNQR-NKEQEDIVVLKAKKKTLEFELEALNDKKHQLEG 494
E +R+ W ER +QE Q+ +EQE+ + K++ E L+ + QL
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Query: 495 KLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQ 554
+ ++ R +L + +E + RE R+ ++Q + Q+L R E++ +LK+
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLK-----REQEERRDQLLKR---EEERRQQRLKR 592
Query: 555 VQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIH 614
Q+ L + LE +E Q L+ + E E+E R +L + E +E
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKRE--EPEEERRQQLLK--------SEEQEER 642
Query: 615 NKQQLQK-QKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRP 673
+QQL++ Q+ +RLK++E+E ++ + K++ E +RR QE L +QE +R
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE-----LAEEEQEQARERI 697
Query: 674 RKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK 729
+ + + + E + + + Q+ R Q ++ + + W E+
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Score = 118 bits (295), Expect = 6e-26
Identities = 113/410 (27%), Positives = 214/410 (52%), Gaps = 56/410 (13%)
Query: 335 LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRK----EQERLAQLERAE 390
LE+EQQ ++ F +++ + E LE+ +Q +Q+++ E+++L + ER +
Sbjct: 1488 LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Query: 391 QERKERERQ--EQERKRQLELEKQLEKQRELERQREEE---RRKEIERR----EAAKREL 441
Q R++R+R+ E+E+ RQ E+QL +Q + R EE RR+E ER+ E R
Sbjct: 1548 QRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQ 1607
Query: 442 ERQRQLEWERNRR----QELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQ 497
E Q+QL ER+R+ ++LL +R ++Q L +++ +F E ++ + E +L+
Sbjct: 1608 EGQQQLRQERDRKFREDEQLLQEREEQQ-----LHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 498 DIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQ 557
R R + +++ + ++LR E ++ +E +Q L R E++ L ++ +Q+++
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQE---RDRKFREEEQQLRRQERERKFLQEE-QQLRR 1718
Query: 558 NSLHRD--SLVTLKRALEAKELARQHL------RDQLDEVEKETRSKLQEIDIFNNQLKE 609
L R L++ E ++L RQ +QL +E + + QE D + ++
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 610 LREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWL---EHVQQ 666
LR+ +QQL+ Q+S K +E+E +L +++EE Q R Q+RD ++ E +Q
Sbjct: 1779 LRQEREEQQLRSQESDR----KFREEE----QLRQEREEQQLRPQQRDGKYRWEEEQLQL 1830
Query: 667 EDEHQRPRKLHE-----------EEKLKREESVKKKDGEEKGKQEAQDKL 705
E++ QR R+ + +EK +REE ++ E+K +QE + KL
Sbjct: 1831 EEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKL 1880
Score = 117 bits (293), Expect = 1e-25
Identities = 118/495 (23%), Positives = 235/495 (47%), Gaps = 56/495 (11%)
Query: 262 IWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVIS 321
I L D+D +G++ EF+L + + Q L +R R S++
Sbjct: 57 ILELLDLDSNGRVDFNEFLLFIFKV-----AQACYYALGQATGLDEEKRARCDGKESLLQ 111
Query: 322 STSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKR--RQALLEQQRKE 379
++ ++ E +QLE++ P +KR+ ER E E++ +Q LE QR
Sbjct: 112 DRRQEE---DQRRFEPRDRQLEEE-PGQRRRQKRQEQERELAEGEEQSEKQERLE-QRDR 166
Query: 380 QERLAQLERAEQERKERERQEQERKR----------QLELEKQLEKQRELERQREEERRK 429
Q R +L R QE +ERE + E ++ + E+QL ++ LE +R+ K
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226
Query: 430 EIERREAAKRELERQRQLEWERN----RRQELLNQRNKEQEDIVVLKAKKKTLEFELEAL 485
+ +RRE R + + + EW + R++E Q + Q + + +++ + E + L
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 486 NDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEK 545
++ + E + Q +R +R++ E + +E R + +QQ + +Q L R E+
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 546 ---QILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDI 602
Q+ +Q ++ ++ L R+ + ++L R+ + ++ +E + + ++
Sbjct: 347 REQQLRREQEEERREQQLRREQ----EEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Query: 603 FNNQLKELREIHNKQQLQKQKSM----EAERLKQK-EQERKIIELE----------KQKE 647
QL+ +++ +QQL++++ + E ER +QK EQER+ L+ K++E
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 648 EAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKL----KREESVKKKDGEEK----GKQ 699
E +R QER KQ L+ Q+E+ +R KL EEE+ +RE+ ++++ E + +Q
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 700 EAQDKLGRLFHQHQE 714
E +++L + Q+
Sbjct: 523 EEEERLQQRLRSEQQ 537
Score = 115 bits (288), Expect = 4e-25
Identities = 104/406 (25%), Positives = 208/406 (51%), Gaps = 44/406 (10%)
Query: 337 DEQQQL---EKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRK--EQERLAQLERAEQ 391
+E+QQL E+ E+++ ER LE+ +Q E+ RK E+E+L Q ER EQ
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ-EREEQ 1476
Query: 392 E--RKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEW 449
+ R+ER+R+ E ++QL +++ K RE E + +E RK +E + R+ +++ L+
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 450 ERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQE 509
E+ R++ Q+ ++ D + ++ E E + L+ ++ + +L++ + R Q ++
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK 1596
Query: 510 I----------ESTNKSRELRIAEITHLQQQLQE-SQQMLGRLIPEKQILNDQ---LKQV 555
E + R+ R + +Q LQE +Q L R +++ L ++ +Q
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 556 QQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHN 615
++ L D ++ E ++L ++ QL E++ + + +E + Q +E + +
Sbjct: 1657 REQQLRHD---RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL-RRQERERKFLQE 1712
Query: 616 KQQLQKQ-------------KSMEAERLKQKEQERKIIE---LEKQKEEAQRRAQERDKQ 659
+QQL++Q + E E+L+++E+ RKI+E L ++EE Q R QERD++
Sbjct: 1713 EQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Query: 660 WLEHVQ--QEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQD 703
+ E Q QE E Q+ R + K + EE ++++ E++ + + +D
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818
Score = 115 bits (287), Expect = 5e-25
Identities = 102/380 (26%), Positives = 191/380 (50%), Gaps = 34/380 (8%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQ 385
+Q+L E L EQQ ++ + +RE R +L + ++ +Q+ EQER Q
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 386 -LERAEQERK-------ERERQEQE-RKRQLELEKQLEKQRELERQREEERRKEIERRE- 435
L+R ++ER+ E ER EQE RK+QL+ +++ E++ + EEERR++ ERRE
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 436 AAKRELERQRQLEWERNRRQELLNQR----------NKEQEDIVVLKAKKKTLEFELEAL 485
+RE E +R+ +R +E L QR +E+ + ++ + ++K LE E
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Query: 486 NDKKHQLEGKLQDIRCRLTTQRQEIESTNKSR---ELRIAEITHLQQQLQESQQMLGRLI 542
K+ Q E + Q ++ ++Q ++ + R L+ E+ L+Q+ + +Q L R
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE-ERREQRLKREE 624
Query: 543 PEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDE-VEKETRSKLQEID 601
PE++ LK +Q + L ++ + L R+ ++L++ +++E + +E +
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 602 IFNNQLKELREIHN----KQQLQKQKSMEAERLKQKEQERKII-ELEKQKEEAQRRAQER 656
+ + ++ RE K Q Q + +A + K + RK + +Q++E +RR +E
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 657 DKQWLE----HVQQEDEHQR 672
+ QW E H QQ++E QR
Sbjct: 745 ELQWQEEERAHRQQQEEEQR 764
Score = 115 bits (287), Expect = 5e-25
Identities = 103/405 (25%), Positives = 206/405 (50%), Gaps = 41/405 (10%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQ 385
+Q L EEP E ++Q +K E+ ++E + E EKRR+ E+Q ++++ L Q
Sbjct: 971 EQLLGEEP--EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 386 LERA--EQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELER 443
E +ER++R QE+ER+ + E E Q E+++ L +RE RR+E+ER+ + EL++
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 444 QRQL----EWERNRRQELLNQRNKE-----QEDIVVLKAKKKTLEFELEALNDKKHQLEG 494
+ + E E+ RRQE Q +E +E+ ++ + ++K ELE ++ +++
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Query: 495 KLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQ 554
+ + + +R+ E + RE +++LQ+ ++ L R EK+ + +
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYRE---------EEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 555 VQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIH 614
++ L R ++ E R L+ Q E EKE + ++ + ++ R++
Sbjct: 1200 REEEELQRQK----RKQRYRDEDQRSDLKWQW-EPEKENAVRDNKVYCKGRENEQFRQLE 1254
Query: 615 NKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQW-----LEHVQQEDE 669
+ Q +Q + + L ++QER +E+ +RR Q+RD+ + LE +Q++
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQER-------DREQERRRWQQRDRHFPEEEQLEREEQKEA 1307
Query: 670 HQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQE 714
+R RK EE++L REE +K+ +E ++ +++ +L + +E
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE--QLLQEREE 1350
Score = 115 bits (287), Expect = 5e-25
Identities = 112/408 (27%), Positives = 216/408 (52%), Gaps = 43/408 (10%)
Query: 326 DQRLPEEPVLEDEQQQ--LEKKLPVTFEDKKRENF-ERGNLELEKRRQALLEQQ-RKEQE 381
D++ EE + EQ + LE++ + ++++R+ E L ++R Q L + + RK +E
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 382 RLAQLERAEQERKERERQEQERKRQ-----LELEKQLEKQR-----ELERQREEERRKEI 431
QL R E++RK RE ++Q R+++ LE E+QL ++R E E+ +E +++
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478
Query: 432 ERREAAKRELERQRQLE-WERNRR---QELLNQRNK-----EQEDIVVLKAKKKTLEFEL 482
R+E ++ LE ++QL ER+R+ QEL +Q + E++ + + ++K L+ E
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ 1538
Query: 483 EALNDKKHQLEGKLQDIRCRLTTQ-RQEIESTNKSRELRIAEITHLQQQLQESQQMLGRL 541
+ ++ Q + +D + R Q RQE E SR+ R + +Q+++ +Q +
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598
Query: 542 IPEKQILND----QLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKL 597
E+Q+ QL+Q + D + +R E ++L RQ + E E + R +
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQER--EEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 598 QEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERD 657
+E + +++ ++ RE +Q LQ+ E ++L+++E++RK E EE Q R QER+
Sbjct: 1657 REQQLRHDRDRKFRE--EEQLLQEG---EEQQLRRQERDRKFRE-----EEQQLRRQERE 1706
Query: 658 KQWLEHVQQEDEHQRPRKLHEEEKLKRE---ESVKKKDGEEKGKQEAQ 702
+++L+ QQ + RK EEE+L++E E +++++ K +E Q
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Score = 114 bits (284), Expect = 1e-24
Identities = 112/411 (27%), Positives = 208/411 (50%), Gaps = 48/411 (11%)
Query: 325 VDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNL---ELEKRRQALLEQQ----- 376
+ QRL E L EQ++ ++L E+K+ E R E E+RR LL+++
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ 587
Query: 377 ----RKEQERLAQ------LERAEQE-----RKERERQEQERKRQ-LELEKQLEKQRELE 420
R+++ERL Q +ER EQE R +RE E+ER++Q L+ E+Q E++++
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 421 RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKK---T 477
R+ ++ERR++ +RE + LE++ + E E RR++ L + +EQ + K
Sbjct: 648 RREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQ 707
Query: 478 LEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQM 537
LE E +A K + K + R R Q QE + + EL+ E +Q QE +Q
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRR---QEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 538 LGRLIPEKQILNDQLKQVQQNSLHRDSL-VTLKRALEAKELARQHLRDQLDEVEKETRSK 596
R + ++ ++ +Q R L +R L A+E ++ R +E EKE R +
Sbjct: 765 --RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 597 LQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQER 656
+ + KEL+ + ++QLQ+++ A++L+++E L++ +E + + Q R
Sbjct: 823 QR-----REREKELQFLEEEEQLQRRE--RAQQLQEEED-----GLQEDQERRRSQEQRR 870
Query: 657 DKQW---LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDK 704
D++W LE ++ H K +E+L++E+ + +++ EE ++E + +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Score = 114 bits (284), Expect = 1e-24
Identities = 108/405 (26%), Positives = 200/405 (49%), Gaps = 47/405 (11%)
Query: 336 EDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQR-KEQERLAQLERAE---Q 391
E+ QQ+ ++ LP E++++E R E EK Q L E+++ + +ER QL+ E Q
Sbjct: 801 EERQQREQRFLP---EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Query: 392 ERKERERQ-------------EQERKR-------------QLELEKQLEKQRELERQREE 425
E +ER R E+ERKR QL E+QL ++ E E QREE
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 426 ERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEAL 485
++ + +E RE E Q Q E E+ R+E +R +E+E K + E +L
Sbjct: 918 REKRRRQEQERQYRE-EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGE 976
Query: 486 NDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQ----QQLQESQQMLGRL 541
+K + + + + R Q++E + + RE R + Q +LQ+ ++ L R
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 542 IPEKQILNDQLKQV-QQNSLHRDSLVTLKRALEAK---ELARQHLRDQLDEVEKETRSKL 597
EK+ L ++ +Q ++ L ++ L E + EL RQ+ ++ +E+++E L
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE--EELQQEEEQLL 1094
Query: 598 QEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERD 657
+E + + R+ +++LQ++ E + L+++ ++R+ ELE+Q E + QE +
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQE---EEQLLREEREKRRRQELERQYREEEEVQQEEE 1151
Query: 658 KQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQ 702
+ E ++ + R+ EEE+L++EE ++ +EK +QE +
Sbjct: 1152 QLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196
Score = 109 bits (273), Expect = 2e-23
Identities = 117/441 (26%), Positives = 216/441 (48%), Gaps = 47/441 (10%)
Query: 309 RRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDK-----KRENFERGNL 363
+R+RS + +Q L E EQ++ E++L E++ KRE ER
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE-ERRQQ 588
Query: 364 ELEKRRQALLEQQ--RKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELER 421
L++ ++ LEQ+ R+E ERL Q ER EQ K E +E+ R++ L+ E+Q E++++ R
Sbjct: 589 RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648
Query: 422 QREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKK---TL 478
+ ++ERR++ +RE + LE++ + E E RR++ L + +EQ + K L
Sbjct: 649 REQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL 708
Query: 479 EFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQML 538
E E +A K + K + R R Q QE + + EL+ E +Q QE +Q
Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRR---QEQEEKRRRRESELQWQEEERAHRQQQEEEQR- 764
Query: 539 GRLIPEKQILNDQLKQVQQNSLHRDSLVTLK-RALEAKELARQHLRDQLDEVEKETRSKL 597
R + ++ ++ +Q R L + R L A+E ++ R +E EKE R +
Sbjct: 765 -RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 598 QEIDIFNNQLKELREIHNKQQLQK----QKSMEAERLKQKEQERKIIELEKQ-------- 645
+ + KEL+ + ++QLQ+ Q+ E E Q++QER+ + +++
Sbjct: 824 RR-----EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 646 KEEAQRRA---------QERDKQWLEHVQQEDEH----QRPRKLHEEEKLKREESVKKKD 692
+EE +RR QE+ ++ + +Q+E+E +R ++ +E++ + E + +
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 693 GEEKGKQEAQDKLGRLFHQHQ 713
EE+ +E ++K R + Q
Sbjct: 939 EEEQLLREEREKRRRQERERQ 959
Score = 104 bits (259), Expect = 8e-22
Identities = 86/371 (23%), Positives = 188/371 (50%), Gaps = 20/371 (5%)
Query: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
+L ++Q++ ++ ++ + R E LE E++++A ++ ++E+ QL R E+E
Sbjct: 1270 LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK--QLLREEREE 1327
Query: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
K R RQE +RK E+QL ++RE + R +ER ++ E +E R+ E +R R
Sbjct: 1328 KRR-RQETDRK--FREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
RQE + KE++ + + +++ + +++ QL + +D + R + Q++
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR--EEEQQVRRQ 1442
Query: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALE 573
+ R+ L+++ Q Q+ + E+Q+L ++ +Q + ++ L
Sbjct: 1443 ERERKF-------LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 574 AKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQK 633
+E R+ +L E E R L+E + Q ++ + + +QQL++Q+ + R +
Sbjct: 1496 RQERDRKFREQELRSQEPE-RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 634 EQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693
+ R+ +L +++EE Q QERD+++ Q+ ++ RK E+ E+ +++++G
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED-----EQQLRRQEG 1609
Query: 694 EEKGKQEAQDK 704
+++ +QE K
Sbjct: 1610 QQQLRQERDRK 1620
Score = 102 bits (254), Expect = 3e-21
Identities = 98/430 (22%), Positives = 209/430 (48%), Gaps = 72/430 (16%)
Query: 331 EEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKE-QERLA----- 384
++ + ++Q++ E++L E+++ E + E E+R Q L E+++++ +ER+
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 385 ---QLE---------------RAEQERKERERQEQERKRQLELEKQLEKQRELERQREEE 426
QLE + E +R+ +E++E+ R+R+ EL+ Q E++ ++Q EE+
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 427 R----------------RKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVV 470
R R+ + R + + ERQ + E + R Q L + ++++
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 471 LKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQ 530
+ ++K L+F E ++ + +LQ+ L QE + +S+E R + + Q
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGL----QEDQERRRSQEQRRDQ--KWRWQ 877
Query: 531 LQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVE 590
L+E ++ + K L +QL++ QQ L + L+ +E ++ ++Q +
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQ------LLQEEEEELQREEREKRRRQEQERQYR 931
Query: 591 KETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSM----------EAERLKQKEQERKII 640
+E + + +E + + ++ R ++Q +K K + E E+ +++E+E+K
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 641 ELEK-QKEEAQRRAQERDK----QWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEE 695
E E+ Q+EE Q +ER+K +W +++DE Q+ EEE+L REE K++ E
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ-----EEEQLLREEREKRRLQER 1046
Query: 696 KGKQEAQDKL 705
+ + +++L
Sbjct: 1047 ERQYREEEEL 1056
Score = 87.8 bits (216), Expect = 8e-17
Identities = 89/381 (23%), Positives = 181/381 (47%), Gaps = 54/381 (14%)
Query: 320 ISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKE 379
+ V ++ E +EDEQQ ++ ++ F L++R + L +Q ++
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERD 1642
Query: 380 QERLAQLERAEQERKERERQ-EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAK 438
++ L E + R+ERE+Q +R R+ E+QL ++ E ++ R +ER ++ E
Sbjct: 1643 RKFLE--EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 439 RELERQRQ-LEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQ 497
R ER+R+ L+ E+ R++ L ++ +E+E + +++T + +L + LE +
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQL-----RQETEQEQLRRQERYRKILEEE-- 1753
Query: 498 DIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQ 557
+L +R+E + + R+ + E L+Q+ +E QQ+ + K +QL+Q ++
Sbjct: 1754 ----QLRPEREEQQLRRQERDRKFREEEQLRQE-REEQQLRSQESDRKFREEEQLRQERE 1808
Query: 558 NSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQ 617
R K E ++L QL+E E + LR+ ++Q
Sbjct: 1809 EQQLRPQQRDGKYRWEEEQL-------QLEEQE-----------------QRLRQERDRQ 1844
Query: 618 QLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLH 677
+++ E+ +++EQ E +EE Q+R QER+++ E EH R R+
Sbjct: 1845 YRAEEQFATQEKSRREEQ-------ELWQEEEQKRRQERERKLRE------EHIR-RQQK 1890
Query: 678 EEEKLKREESVKKKDGEEKGK 698
EE++ ++ +K ++G+ G+
Sbjct: 1891 EEQRHRQVGEIKSQEGKGHGR 1911
Score = 55.5 bits (132), Expect = 5e-07
Identities = 52/176 (29%), Positives = 89/176 (50%), Gaps = 23/176 (13%)
Query: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
+LE+EQ + E++ + +R+ +R E E+ RQ EQQ + QE + EQ R
Sbjct: 1749 ILEEEQLRPEREE----QQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804
Query: 394 KERERQE---QER-------KRQLELEKQLEKQRELERQREEERRKEIERREAAKREL-- 441
+ERE Q+ Q+R + QL+LE+Q ++ R+ ER R+ ++ +E ++RE
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ-ERDRQYRAEEQFATQEKSRREEQE 1863
Query: 442 -----ERQRQLEWERNRRQE-LLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQ 491
E++R+ E ER R+E + Q+ +EQ V + K + + L HQ
Sbjct: 1864 LWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQ 1919
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 122 bits (306), Expect = 3e-27
Identities = 97/362 (26%), Positives = 170/362 (46%), Gaps = 35/362 (9%)
Query: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIM 1290
LT E RQ I+EL VTE +++ L+++ IF + + + L+ +E+A +F N ELI
Sbjct: 768 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 827
Query: 1291 CNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQ 1344
+ +A+ KK+ E +K I D++ A+ Q +FCS Q LI+
Sbjct: 828 IHNSWCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIK 884
Query: 1345 QKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHS 1404
K + F+ F++ P+C+ + L I+ MQR+T+YPL++++I+++T +H
Sbjct: 885 TKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHE 944
Query: 1405 HLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCLGPR 1461
L A ++ E+ VNE V++ EN RLE Q + L S L + L R
Sbjct: 945 KLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTR 1004
Query: 1462 KFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-----------ITKPLGSSGTDKVFSP 1507
K +H G L ++ +K +L+ L D L+L Q +GSS + + FSP
Sbjct: 1005 KMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSP 1064
Query: 1508 KSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIK 1567
L + ++ + T G ++Y L A + +++ W++ ++
Sbjct: 1065 VLKLNAVLIRSVATDKRAFFIICTSKLGP---------PQIYELVALTSSDKNTWMELLE 1115
Query: 1568 AA 1569
A
Sbjct: 1116 EA 1117
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 122 bits (306), Expect = 3e-27
Identities = 97/362 (26%), Positives = 170/362 (46%), Gaps = 35/362 (9%)
Query: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIM 1290
LT E RQ I+EL VTE +++ L+++ IF + + + L+ +E+A +F N ELI
Sbjct: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 787
Query: 1291 CNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQ 1344
+ +A+ KK+ E +K I D++ A+ Q +FCS Q LI+
Sbjct: 788 IHNSWCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIK 844
Query: 1345 QKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHS 1404
K + F+ F++ P+C+ + L I+ MQR+T+YPL++++I+++T +H
Sbjct: 845 TKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHE 904
Query: 1405 HLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCLGPR 1461
L A ++ E+ VNE V++ EN RLE Q + L S L + L R
Sbjct: 905 KLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTR 964
Query: 1462 KFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-----------ITKPLGSSGTDKVFSP 1507
K +H G L ++ +K +L+ L D L+L Q +GSS + + FSP
Sbjct: 965 KMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSP 1024
Query: 1508 KSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIK 1567
L + ++ + T G ++Y L A + +++ W++ ++
Sbjct: 1025 VLKLNAVLIRSVATDKRAFFIICTSKLGP---------PQIYELVALTSSDKNTWMELLE 1075
Query: 1568 AA 1569
A
Sbjct: 1076 EA 1077
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
sapiens]
Length = 532
Score = 122 bits (305), Expect = 4e-27
Identities = 90/327 (27%), Positives = 162/327 (49%), Gaps = 34/327 (10%)
Query: 1207 NYVKLTTDMDPSQQWCS--DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1264
N +T S+ W D+ + MLT E KRQ I EL EE+ + DL+L + +
Sbjct: 96 NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH 155
Query: 1265 KPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLP 1324
P+++ ++TE+E+ IF LI + +LL LR +K G + +G IL LP
Sbjct: 156 DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGS---TEHVGPILVGWLP 212
Query: 1325 HMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTR 1384
+ Y +CS Q+ AL+ K + ++F++R P + + L +F+ P R+ +
Sbjct: 213 CLSSYDSYCSNQVAAKALLDHKKQDHR-VQDFLQRCLESPFSRKLDLWNFLDIPRSRLVK 271
Query: 1385 YPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKE---NSDRLEWIQAHVQ 1441
YPL+++ IL +TP ++PD HL+ A+ + + +++N E E +RL +++
Sbjct: 272 YPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLE---- 327
Query: 1442 CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGT 1501
EG + L+ +S C G+L K +L+ FLF + L++T
Sbjct: 328 -EGQKDSLIDSSRVLCC-------HGEL-KNNRGVKLHVFLFQEVLVIT----------- 367
Query: 1502 DKVFSPKSNLQYKMYKTPIFLNEVLVK 1528
+ + L Y++Y+ PI + ++L++
Sbjct: 368 -RAVTHNEQLCYQLYRQPIPVKDLLLE 393
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
sapiens]
Length = 558
Score = 122 bits (305), Expect = 4e-27
Identities = 90/327 (27%), Positives = 162/327 (49%), Gaps = 34/327 (10%)
Query: 1207 NYVKLTTDMDPSQQWCS--DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1264
N +T S+ W D+ + MLT E KRQ I EL EE+ + DL+L + +
Sbjct: 122 NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH 181
Query: 1265 KPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLP 1324
P+++ ++TE+E+ IF LI + +LL LR +K G + +G IL LP
Sbjct: 182 DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGS---TEHVGPILVGWLP 238
Query: 1325 HMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTR 1384
+ Y +CS Q+ AL+ K + ++F++R P + + L +F+ P R+ +
Sbjct: 239 CLSSYDSYCSNQVAAKALLDHKKQDHR-VQDFLQRCLESPFSRKLDLWNFLDIPRSRLVK 297
Query: 1385 YPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKE---NSDRLEWIQAHVQ 1441
YPL+++ IL +TP ++PD HL+ A+ + + +++N E E +RL +++
Sbjct: 298 YPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLE---- 353
Query: 1442 CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGT 1501
EG + L+ +S C G+L K +L+ FLF + L++T
Sbjct: 354 -EGQKDSLIDSSRVLCC-------HGEL-KNNRGVKLHVFLFQEVLVIT----------- 393
Query: 1502 DKVFSPKSNLQYKMYKTPIFLNEVLVK 1528
+ + L Y++Y+ PI + ++L++
Sbjct: 394 -RAVTHNEQLCYQLYRQPIPVKDLLLE 419
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 122 bits (305), Expect = 4e-27
Identities = 90/327 (27%), Positives = 162/327 (49%), Gaps = 34/327 (10%)
Query: 1207 NYVKLTTDMDPSQQWCS--DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1264
N +T S+ W D+ + MLT E KRQ I EL EE+ + DL+L + +
Sbjct: 90 NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH 149
Query: 1265 KPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLP 1324
P+++ ++TE+E+ IF LI + +LL LR +K G + +G IL LP
Sbjct: 150 DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGS---TEHVGPILVGWLP 206
Query: 1325 HMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTR 1384
+ Y +CS Q+ AL+ K + ++F++R P + + L +F+ P R+ +
Sbjct: 207 CLSSYDSYCSNQVAAKALLDHKKQDHR-VQDFLQRCLESPFSRKLDLWNFLDIPRSRLVK 265
Query: 1385 YPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKE---NSDRLEWIQAHVQ 1441
YPL+++ IL +TP ++PD HL+ A+ + + +++N E E +RL +++
Sbjct: 266 YPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLE---- 321
Query: 1442 CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGT 1501
EG + L+ +S C G+L K +L+ FLF + L++T
Sbjct: 322 -EGQKDSLIDSSRVLCC-------HGEL-KNNRGVKLHVFLFQEVLVIT----------- 361
Query: 1502 DKVFSPKSNLQYKMYKTPIFLNEVLVK 1528
+ + L Y++Y+ PI + ++L++
Sbjct: 362 -RAVTHNEQLCYQLYRQPIPVKDLLLE 387
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 [Homo
sapiens]
Length = 596
Score = 122 bits (305), Expect = 4e-27
Identities = 100/370 (27%), Positives = 176/370 (47%), Gaps = 55/370 (14%)
Query: 1224 DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFV 1283
D+ + + LT E +RQ I+E+ E++ + DL+L + + P+++ +++E+E+ IF
Sbjct: 161 DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 220
Query: 1284 NWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALI 1343
+ I + LL + K G V+ IG IL + LP + Y +CS QL AL+
Sbjct: 221 DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 277
Query: 1344 QQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDH 1403
QK + P ++F++R P + + L SF+ P R+ +YPL++K IL++TP+ HPD
Sbjct: 278 DQKKQD-PRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 336
Query: 1404 SHLKHALEKAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLSEQLVFNSVTNCLGP 1460
L+ A+ + + S +N E E D+LE++ + ++ + V C G
Sbjct: 337 QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQR----DPRIEASKVLLCHGE 392
Query: 1461 RKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPI 1520
++KS +LY FLF D L+LT + + Y++Y+ PI
Sbjct: 393 ---------LRSKSGHKLYIFLFQDILVLT------------RPVTRNERHSYQVYRQPI 431
Query: 1521 FLNEVLVKLPTDPSGD-----------------EPIFHISHID----RVYTLRAESINER 1559
+ E++++ D GD + IF I D + +TL+A + +
Sbjct: 432 PVQELVLEDLQD--GDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHK 489
Query: 1560 TAWVQKIKAA 1569
W I+AA
Sbjct: 490 QQWFNCIRAA 499
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [Homo
sapiens]
Length = 542
Score = 122 bits (305), Expect = 4e-27
Identities = 100/370 (27%), Positives = 176/370 (47%), Gaps = 55/370 (14%)
Query: 1224 DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFV 1283
D+ + + LT E +RQ I+E+ E++ + DL+L + + P+++ +++E+E+ IF
Sbjct: 107 DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 166
Query: 1284 NWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALI 1343
+ I + LL + K G V+ IG IL + LP + Y +CS QL AL+
Sbjct: 167 DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 223
Query: 1344 QQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDH 1403
QK + P ++F++R P + + L SF+ P R+ +YPL++K IL++TP+ HPD
Sbjct: 224 DQKKQD-PRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 282
Query: 1404 SHLKHALEKAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLSEQLVFNSVTNCLGP 1460
L+ A+ + + S +N E E D+LE++ + ++ + V C G
Sbjct: 283 QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQR----DPRIEASKVLLCHGE 338
Query: 1461 RKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPI 1520
++KS +LY FLF D L+LT + + Y++Y+ PI
Sbjct: 339 ---------LRSKSGHKLYIFLFQDILVLT------------RPVTRNERHSYQVYRQPI 377
Query: 1521 FLNEVLVKLPTDPSGD-----------------EPIFHISHID----RVYTLRAESINER 1559
+ E++++ D GD + IF I D + +TL+A + +
Sbjct: 378 PVQELVLEDLQD--GDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHK 435
Query: 1560 TAWVQKIKAA 1569
W I+AA
Sbjct: 436 QQWFNCIRAA 445
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 120 bits (302), Expect = 9e-27
Identities = 143/541 (26%), Positives = 230/541 (42%), Gaps = 42/541 (7%)
Query: 36 SGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLP 95
+G + A F +SGLP +L +IW LAD + G +++ EF +A++L+ G ++
Sbjct: 31 TGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS 90
Query: 96 -SALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVV--GMSPTLVSSVPT 152
S+L + +S+P G A+ P AV P + +SP
Sbjct: 91 LSSLNLAVPPPRFHDTSSPLLISGTSAAELPW-AVKPEDKAKYDAIFDSLSPVNGFLSGD 149
Query: 153 AAVPPLANGAPPV-----IQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVA 207
P L N PV + L H + + L K S A
Sbjct: 150 KVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALE-KEPVPMSLPPA 208
Query: 208 SVPPVAE--WAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNL 265
VPP W V + + KY ++F DK M G ++G + R I +++ LP LA IW+L
Sbjct: 209 LVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSL 268
Query: 266 SDIDQDGKLTAEEFILAMHLIDVAM-SGQPLPPVLPPEYIPPSFR-----RVRSGSGISV 319
D GKL+ ++F LA HLI + G P VL PE IPPS R + S ++
Sbjct: 269 CDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVAD 328
Query: 320 ISSTSVDQRLPEEPV-LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRR-----QALL 373
S+ L E V L+ E+ +E+ L + K+ E +L+ E +R Q L
Sbjct: 329 FSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ 388
Query: 374 EQQRKEQERLAQLER-----AEQERKERERQEQERKRQLELEKQLEKQRELERQREEE-- 426
Q+++ QE L +L+ EQ ++ R++ +E + L+ +L Q EEE
Sbjct: 389 AQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
Query: 427 -RRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAK---KKTLEFEL 482
R+E+ R + ELE +E + + + L Q++I ++ K K LE
Sbjct: 449 KAREELSRLQQETAELE--ESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHN 506
Query: 483 EALN--DKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRI---AEITHLQQQLQESQQM 537
LN H + C L+T E + N+ E + +E H + + S ++
Sbjct: 507 SQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPEL 566
Query: 538 L 538
L
Sbjct: 567 L 567
Score = 82.8 bits (203), Expect = 3e-15
Identities = 34/88 (38%), Positives = 60/88 (68%)
Query: 15 WAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMD 74
WA+ E++AK+D F SL P++GF++GD+ + S LP +L ++W L+D+++DG +D
Sbjct: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
Query: 75 QVEFSIAMKLIKLKLQGYQLPSALPPVM 102
+ EF++AM L+ L+ +P +LPP +
Sbjct: 182 RDEFAVAMFLVYCALEKEPVPMSLPPAL 209
Score = 65.5 bits (158), Expect = 4e-10
Identities = 33/90 (36%), Positives = 54/90 (60%), Gaps = 2/90 (2%)
Query: 15 WAITVEERAKHDQQFHSL-KPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRM 73
W ++ E+AK+D+ F K + GF++G + R F ++GLP +LA IW+L D + G++
Sbjct: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
Query: 74 DQVEFSIAMKLIKLKL-QGYQLPSALPPVM 102
+ +F++A LI KL +G P L P M
Sbjct: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEM 307
Score = 51.2 bits (121), Expect = 8e-06
Identities = 43/194 (22%), Positives = 93/194 (47%), Gaps = 17/194 (8%)
Query: 417 RELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKK 476
+EL+ E + E+ + E++ ++ + Q+L ++ +E ++ L+A+K+
Sbjct: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
Query: 477 TLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQ 536
++ L+ L+++K QLE +L+++R + + Q I S AE+T + Q+ ++
Sbjct: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLK-------AELTSQESQISTYEE 445
Query: 537 MLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSK 596
L + ++L ++QQ + + V +A E +QHL+D E+ + K
Sbjct: 446 ELAK-------AREELSRLQQETAELEESVESGKA--QLEPLQQHLQDSQQEI-SSMQMK 495
Query: 597 LQEIDIFNNQLKEL 610
L E+ N +L
Sbjct: 496 LMEMKDLENHNSQL 509
Score = 46.2 bits (108), Expect = 3e-04
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 225 YRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMH 284
Y + + D +G + A L +S LP L IW+L+D D G L +EF +A+
Sbjct: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Query: 285 LIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTS 324
L+ A +G + +PP R S +IS TS
Sbjct: 79 LVACAQNGLEVSLSSLNLAVPPP--RFHDTSSPLLISGTS 116
Score = 45.4 bits (106), Expect = 5e-04
Identities = 32/147 (21%), Positives = 70/147 (47%), Gaps = 4/147 (2%)
Query: 413 LEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLK 472
++ QRE ++ + KE ++ + Q +++ E Q+L Q+ + QE + L
Sbjct: 343 VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELD 402
Query: 473 AKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQ 532
+K LE +L+ + K + + ++ LT+Q +I + + E++ LQQ+
Sbjct: 403 EQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETA 462
Query: 533 ESQQML----GRLIPEKQILNDQLKQV 555
E ++ + +L P +Q L D +++
Sbjct: 463 ELEESVESGKAQLEPLQQHLQDSQQEI 489
Score = 42.0 bits (97), Expect = 0.005
Identities = 32/102 (31%), Positives = 56/102 (54%), Gaps = 10/102 (9%)
Query: 595 SKLQEIDIFNNQLKEL-REIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653
S ++E+D NN++ +L RE +N +Q K+K + +KQ+ E + ++ E Q+E +
Sbjct: 330 SAIKELDTLNNEIVDLQREKNNVEQDLKEKE---DTIKQRTSEVQDLQDEVQRENTNLQK 386
Query: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEE 695
+ KQ ++ + E + Q K EE+LK V+KK EE
Sbjct: 387 LQAQKQQVQELLDELDEQ---KAQLEEQLK---EVRKKCAEE 422
Score = 36.2 bits (82), Expect = 0.28
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 24/157 (15%)
Query: 573 EAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQ 632
E +L R+ + D EKE K + ++ + Q + RE N Q+LQ QK E L
Sbjct: 341 EIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLD- 399
Query: 633 KEQERKIIELEKQKEEAQRRAQERDKQWLEHVQ-----------QEDE----HQRPRKLH 677
EL++QK + + + +E K+ E Q QE + + K
Sbjct: 400 --------ELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR 451
Query: 678 EEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQE 714
EE ++E+ + ++ E GK + + L QE
Sbjct: 452 EELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQE 488
Score = 35.4 bits (80), Expect = 0.48
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 23/189 (12%)
Query: 508 QEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVT 567
+E+++ N E +++Q L+E + + + E Q L D++++ N
Sbjct: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNL-------- 384
Query: 568 LKRALEAKELARQHLRDQLDEVE-------KETRSK-LQEIDIFNNQLKELREIHNKQQL 619
+ L+A++ Q L D+LDE + KE R K +E + ++ EL ++
Sbjct: 385 --QKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQIST 442
Query: 620 QKQKSMEA-ERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHE 678
+++ +A E L + +QE +E + +AQ E +Q L+ QQE + KL E
Sbjct: 443 YEEELAKAREELSRLQQETAELEESVESGKAQ---LEPLQQHLQDSQQEISSMQ-MKLME 498
Query: 679 EEKLKREES 687
+ L+ S
Sbjct: 499 MKDLENHNS 507
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 119 bits (299), Expect = 2e-26
Identities = 125/483 (25%), Positives = 217/483 (44%), Gaps = 64/483 (13%)
Query: 1126 GWFPANYVKLLSPGTS--------------KITPTEPPKSTALAAVCQVIGMYDYTAQND 1171
G+ PAN + ++ G S ++ T P T + ++D+
Sbjct: 659 GYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPL 718
Query: 1172 DELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMD---PSQQWCSDLHLL 1228
D++ + ++ V P ++ + G S + D++ P+ Q +L
Sbjct: 719 DQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVL 778
Query: 1229 DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKEL 1288
L P E KRQ I+EL TE +V L+++ ++F + + +L+ E+ IF N +++
Sbjct: 779 LGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDI 838
Query: 1289 IMCNIKLLKALRVRKKMSGEKMPVKMIGDIL--------SAQLPHMQPYIRFCSRQLNGA 1340
+ +I L + ++ +K + E + IG+ L +L H FCS Q
Sbjct: 839 LQLHIGLNEQMKAVRKRN-ETSVIDQIGEDLLTWFSGPGEEKLKHAAA--TFCSNQPFAL 895
Query: 1341 ALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENH 1400
+I+ + + F+ FV+ +P C+ + L I MQR+T+YPL++ NI + T E
Sbjct: 896 EMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYT-EWP 954
Query: 1401 PDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEG--LSEQLVFNSVTNC- 1457
+ +K A + ++ + VN+ V+E EN RLE Q + LSE + N
Sbjct: 955 TEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLD 1014
Query: 1458 LGPRKFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ----------ITKPLGSSGTDK- 1503
L RK +H G L +K +K +LY L D L+L Q +K L S+ K
Sbjct: 1015 LTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKH 1074
Query: 1504 VFSPKSNLQYKMYKTPIFLNEVLVK-LPTDPSGDEPIFHISHID---RVYTLRAESINER 1559
FSP I L+ VLV+ + TD ++ +F IS D ++Y L A++++E+
Sbjct: 1075 TFSP-----------VIKLSTVLVRQVATD---NKALFVISMSDNGAQIYELVAQTVSEK 1120
Query: 1560 TAW 1562
T W
Sbjct: 1121 TVW 1123
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 115 bits (289), Expect = 3e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 494
Query: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 495 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 546
Query: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 547 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 606
Query: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 607 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 660
Query: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 661 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 714
Query: 1199 GQVGLFPSNYVK 1210
G+ G+FP NY++
Sbjct: 715 GKSGIFPKNYIQ 726
Score = 83.6 bits (205), Expect = 2e-15
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 569
Query: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 570 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 622
Query: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 623 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 682
Query: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 683 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 78.6 bits (192), Expect = 5e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 512 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 571
Query: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 572 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 629
Query: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 630 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 685
Query: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 686 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 728
Score = 72.0 bits (175), Expect = 5e-12
Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
A V+ + A + L L G+++ + +K W+ G + QIG FPANYVK++
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIID 495
Query: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
S+ + + ++Y + DEL+F++G+II + + +W +GEV
Sbjct: 496 IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR 555
Query: 1199 GQVGLFPSNYVKLTTDMDPS 1218
G+ G+FP N+V+ D S
Sbjct: 556 GRTGIFPLNFVEPVEDYPTS 575
Score = 46.6 bits (109), Expect = 2e-04
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 642 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 696
Query: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
I + E ++ + W+ GEL GK+G FP NY +
Sbjct: 697 I-------ITELESVDDDWMSGELMGKSGIFPKNYIQ 726
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 115 bits (289), Expect = 3e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 530
Query: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 531 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 582
Query: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 583 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 642
Query: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 643 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 696
Query: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 697 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 750
Query: 1199 GQVGLFPSNYVK 1210
G+ G+FP NY++
Sbjct: 751 GKSGIFPKNYIQ 762
Score = 83.6 bits (205), Expect = 2e-15
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 605
Query: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 606 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 658
Query: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 659 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 718
Query: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 719 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 78.6 bits (192), Expect = 5e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 548 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 607
Query: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 608 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 665
Query: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 666 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 721
Query: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 722 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 764
Score = 72.0 bits (175), Expect = 5e-12
Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
A V+ + A + L L G+++ + +K W+ G + QIG FPANYVK++
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIID 531
Query: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
S+ + + ++Y + DEL+F++G+II + + +W +GEV
Sbjct: 532 IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR 591
Query: 1199 GQVGLFPSNYVKLTTDMDPS 1218
G+ G+FP N+V+ D S
Sbjct: 592 GRTGIFPLNFVEPVEDYPTS 611
Score = 46.6 bits (109), Expect = 2e-04
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 678 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 732
Query: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
I + E ++ + W+ GEL GK+G FP NY +
Sbjct: 733 I-------ITELESVDDDWMSGELMGKSGIFPKNYIQ 762
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 115 bits (289), Expect = 3e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 553
Query: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 554 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 605
Query: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 606 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 665
Query: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 666 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 719
Query: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 720 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 773
Query: 1199 GQVGLFPSNYVK 1210
G+ G+FP NY++
Sbjct: 774 GKSGIFPKNYIQ 785
Score = 83.6 bits (205), Expect = 2e-15
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 628
Query: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 629 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 681
Query: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 682 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 741
Query: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 742 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 78.6 bits (192), Expect = 5e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 571 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 630
Query: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 631 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 688
Query: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 689 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 744
Query: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 745 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 787
Score = 75.9 bits (185), Expect = 3e-13
Identities = 61/265 (23%), Positives = 121/265 (45%), Gaps = 25/265 (9%)
Query: 974 RKSTSMDSGSSESPASLKRVASPAAKP------------VVSGEEFIAMYTYESSEQGDL 1021
+K +++ +G S++ + + + P P ++S IA S G+L
Sbjct: 375 KKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGEL 434
Query: 1022 TFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKD--SEGSGTAGKTGSLGKKP-- 1076
+ ++GDV+++ K+ + ++ G+ G + +++ E + S +KP
Sbjct: 435 SCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVD 494
Query: 1077 ---EIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV 1133
A V+ + A + L L G+++ + +K W+ G + QIG FPANYV
Sbjct: 495 SGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYV 549
Query: 1134 KLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWW 1193
K++ S+ + + ++Y + DEL+F++G+II + + +W
Sbjct: 550 KVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA 609
Query: 1194 KGEVNGQVGLFPSNYVKLTTDMDPS 1218
+GEV G+ G+FP N+V+ D S
Sbjct: 610 RGEVRGRTGIFPLNFVEPVEDYPTS 634
Score = 46.6 bits (109), Expect = 2e-04
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 701 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 755
Query: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
I + E ++ + W+ GEL GK+G FP NY +
Sbjct: 756 I-------ITELESVDDDWMSGELMGKSGIFPKNYIQ 785
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 115 bits (288), Expect = 4e-25
Identities = 73/269 (27%), Positives = 140/269 (52%), Gaps = 7/269 (2%)
Query: 1227 LLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWK 1286
L ++ ERKRQ I E+I +E +Y+ L+++ +F+ S+ +T+ E +F N
Sbjct: 429 LSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNIT 488
Query: 1287 ELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPH-MQPYIRFCSRQLNGAALIQQ 1345
++ + K L R + + + I DI+ PY+++C+ ++ +Q+
Sbjct: 489 DVCEASKKFFIELEARHQ---NNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQK 545
Query: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
P FKE + R+ C+ +P+ SF++ PMQRVTR PL++ I + TP++ P +
Sbjct: 546 LLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEV 605
Query: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS--VTNCLGPRKF 1463
K AL++ +L NEG R+ E ++ + I + ++ + LV +S + +
Sbjct: 606 CKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAY 665
Query: 1464 LHSGKLYKAKSNK-ELYGFLFNDFLLLTQ 1491
+ L+ +++K ++Y FLFND L++T+
Sbjct: 666 VEDTVLFSRRTSKQQVYFFLFNDVLIITK 694
Score = 43.1 bits (100), Expect = 0.002
Identities = 19/55 (34%), Positives = 33/55 (60%), Gaps = 3/55 (5%)
Query: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
+++ S+TA P++L+L ++LI ++ GW+EGE G++ GWFP K
Sbjct: 795 EIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGER---GWFPMECAK 846
Score = 37.0 bits (84), Expect = 0.17
Identities = 36/171 (21%), Positives = 64/171 (37%), Gaps = 16/171 (9%)
Query: 639 IIELEKQKEEAQRRAQE---RDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEE 695
++ + K+K E + RD+ +E E+ + P K R+ S
Sbjct: 689 VLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLT 748
Query: 696 KGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRS 755
A +K+ L + + A W TA + + + F ++
Sbjct: 749 VLSNHANEKVEMLLGAETQSER----ARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQ 804
Query: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGE--LKGKTGWFPANYAEKI 804
DE+++Q D+V++ Q GW GE G+ GWFP A++I
Sbjct: 805 PDELSLQVADVVLI-------YQRVSDGWYEGERLRDGERGWFPMECAKEI 848
Score = 32.3 bits (72), Expect = 4.1
Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 3/57 (5%)
Query: 917 QAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEV--QGQKGWFPKSYVKLIS 970
Q + + + AK+ + L+ DV+ + ++ D W+ GE G++GWFP K I+
Sbjct: 793 QVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT 849
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 115 bits (287), Expect = 5e-25
Identities = 91/394 (23%), Positives = 212/394 (53%), Gaps = 32/394 (8%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQE-RLA 384
++ L E+ L ++++Q++++ +E +++ + + ++ R E+Q +EQE ++
Sbjct: 334 EKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR 393
Query: 385 QLERAEQERKERERQEQERKRQLE-LEKQLEKQRELERQREEER--RKEIERREAAKREL 441
E E+ ER R+++ER R+ E + +Q+EK RE ++ +E+E+ R + E+ + +R
Sbjct: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 442 ERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQL--EGKLQDI 499
ER++++ E +E + K++E++ + K E++ + L ++K +L + K+Q+
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEK----EWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 500 RCRLTTQRQEIESTNK--SRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQ 557
++ Q ++I + +E ++ +++Q + + ++ ++Q + DQ +++++
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 558 NSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQ 617
+ ++ K+ + +E R+ +++ E EK+ R +E ++ Q ++++E K
Sbjct: 570 KTQEQE-----KKTWDQEEKMREE--ERMREREKKMR---EEEEMMREQEEKMQEQEEKM 619
Query: 618 QLQKQKSMEAERLKQK------EQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQ 671
Q Q++K E E Q+ EQE K+ E E++ E QR ++++K W QE E
Sbjct: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
Query: 672 RPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKL 705
+ +EEK+ +E ++KK E++ K Q+K+
Sbjct: 680 Q----EQEEKIWEQEKMEKKTQEQEKKTWDQEKM 709
Score = 107 bits (267), Expect = 1e-22
Identities = 88/405 (21%), Positives = 218/405 (53%), Gaps = 47/405 (11%)
Query: 336 EDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKE 395
E+E ++ EKK+ +K+E ++ ++ + L EQ+ K +E+ ++ R E+ +E
Sbjct: 278 EEELREQEKKI------RKQEE------KMWRQEERLREQEGKMREQEEKMWRQEKRLRE 325
Query: 396 RERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQ 455
+E++ +E++++L +K+L +Q E +++EE+ ++ E+ + ++ RQ + WE+ ++
Sbjct: 326 QEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 456 ELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNK 515
Q+ ++QE+ + + + L + E + +++ E Q + R + QE E +
Sbjct: 386 REQEQKMRDQEE--RMWEQDERLREKEERMREQEKMWE---QVEKMREEKKMQEQEKKTR 440
Query: 516 SRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAK 575
+E ++ E +++++E ++ ++ E++ + +Q +++Q+ + E K
Sbjct: 441 DQEEKMQE----EERIREREK---KMREEEETMREQEEKMQKQEEN-------MWEQEEK 486
Query: 576 ELARQHLRDQLDEVEKETRSKLQEIDIFNNQ--LKELREIHNKQ-QLQKQKSMEAERLKQ 632
E +Q L +Q +++ ++ + + QE I+ + +++ E+ ++ ++ +Q+ M + +
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 633 KEQERKIIELEK----QKEEAQRRAQERDKQ-WLEHVQQEDE---HQRPRKLHEEEKLKR 684
EQE K+ + E+ Q+E +++ QE++K+ W + + +E +R +K+ EEE++ R
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 685 EESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK 729
E+ K ++ EEK QE ++K+ + +E + + W EK
Sbjct: 607 EQEEKMQEQEEK-MQEQEEKM----WEQEEKMQEQEEKMWEQEEK 646
Score = 105 bits (263), Expect = 3e-22
Identities = 91/402 (22%), Positives = 202/402 (50%), Gaps = 36/402 (8%)
Query: 328 RLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLE 387
R EE + E++ E++ + +++K + E E ++R + E+ R++++ Q+E
Sbjct: 365 REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVE 424
Query: 388 RA-------EQERKERERQE--QERKRQLELEKQLEKQRELERQREEERRK------EIE 432
+ EQE+K R+++E QE +R E EK++ ++ E R++EE+ +K E E
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE 484
Query: 433 RREAAKRELERQRQLEWERNRRQELLNQRNKEQEDI-----VVLKAKKKTLEFELEALND 487
+E ++ L Q++ WE+ + QE + +++E I + + KK + ++ D
Sbjct: 485 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Query: 488 KKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQI 547
+ + E K++D ++ Q + +E + +E + + ++ + ++ ++ E+++
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 604
Query: 548 LNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEK---ETRSKLQEIDIFN 604
+ +Q +++Q+ + + + + +E Q +++ E E+ E K+ E
Sbjct: 605 MREQEEKMQEQE---EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 605 NQLKELREIHN-----KQQLQKQKSMEAERLKQK--EQERKIIELEKQKEEAQRRAQE-- 655
Q ++L E K Q Q++K E E++++K EQE+K + EK +EE R +E
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
Query: 656 -RDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEK 696
R+++ + Q+E ++ K+ E+E+ E+ K + EEK
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEK 763
Score = 101 bits (251), Expect = 7e-21
Identities = 102/401 (25%), Positives = 209/401 (52%), Gaps = 35/401 (8%)
Query: 319 VISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRK 378
V ++T ++ +E L ++++++ K+ + ++R + G + ++ + E++ +
Sbjct: 265 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLR 324
Query: 379 EQERLAQLERAEQERKERERQEQERKRQLELEKQLEK---QRELERQREEERRKEIER-- 433
EQE+ E EQE++ RE++E R+++ ++++Q EK Q E R++EE+ ++ ER
Sbjct: 325 EQEK----ELREQEKELREQKEL-REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
Query: 434 -REAAKRELER----QRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDK 488
+E RE E+ Q + WE++ R +R +EQE + + +K E +++ K
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE-QVEKMREEKKMQEQEKK 438
Query: 489 KHQLEGKLQD---IRCRLTTQRQEIESTNKSRE-LRIAEITHLQQQLQESQQMLGRLIPE 544
E K+Q+ IR R R+E E+ + E ++ E +Q+ +E QQ RL +
Sbjct: 439 TRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ--RLPEQ 496
Query: 545 KQILNDQLKQVQQNSLHRDSLVTLKR-----ALEAKELARQHLRDQLDEV-EKETRSKLQ 598
K+ L +Q K +Q + ++ E K ++ +R+Q D++ E+E + + Q
Sbjct: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
Query: 599 EIDIFNNQ---LKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQE 655
E +++ + K+ +E K Q++K E ER+ +E+E+K+ E E+ E + + QE
Sbjct: 557 EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM--REREKKMREEEEMMREQEEKMQE 614
Query: 656 RDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEK 696
++++ E Q+E ++ K+ E+E+ E+ K + EEK
Sbjct: 615 QEEKMQE--QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
Score = 98.6 bits (244), Expect = 5e-20
Identities = 86/408 (21%), Positives = 200/408 (49%), Gaps = 38/408 (9%)
Query: 327 QRLPE--EPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQR----KEQ 380
QRLPE E + E E+ Q +++ E+K R+ E E + RQ + +Q +++
Sbjct: 491 QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 550
Query: 381 ERLAQLERA---EQERKERERQEQERKRQLELEKQLEKQRELERQR-----EEERRKEIE 432
E++ E+ ++ER E++ QEQE+K + EK E++R ER++ EE R++ E
Sbjct: 551 EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
Query: 433 RREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIV------------VLKAKKKTLEF 480
+ + + +++ Q + WE+ + + ++ EQE+ + + + K+K E
Sbjct: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670
Query: 481 ELEALNDKKHQLEGKL-QDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLG 539
E +K + E K+ + + TQ QE ++ ++ + + +++++E ++M+
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 540 RLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
+ Q +++++ ++ ++ + + E K +Q L +Q +++ + K+QE
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQ---EEKMWEQQRLPEQKEKLWEH--EKMQE 785
Query: 600 IDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQ 659
+ Q +++R+ K + Q++K E + ++E+ + EK + ++ + +K
Sbjct: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKM 845
Query: 660 WLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGR 707
W + + E+ K+ +E+ RE+ K + EEK +++ + G+
Sbjct: 846 WGQEEKMEE------KMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Score = 95.5 bits (236), Expect = 4e-19
Identities = 83/381 (21%), Positives = 186/381 (48%), Gaps = 41/381 (10%)
Query: 326 DQRLPEEPVLEDEQQQL---EKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQER 382
DQ +E + D++Q++ E+++ ++++++ +++ E+ R E++ +E+E
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 383 LAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELE 442
+ + + + + +E + QEQE K + EK E++ ++ Q EE+ E E + ++ L
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ--EEKMWEQEEKMWEQQRLP 661
Query: 443 RQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCR 502
Q++ WE + QE + +E++ K +KKT E E + + +K + E + +R R
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE---ESMRER 718
Query: 503 LTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHR 562
R+E E + E +Q+Q ++ Q+ E+++ + K +Q
Sbjct: 719 EKKMREEEEMMREQEE-------KMQEQEEKMQEQ------EEEMWEQEEKMWEQ----- 760
Query: 563 DSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQ 622
E K +Q L +Q +++ + K+QE + Q +++R+ K + Q++
Sbjct: 761 ----------EEKMWEQQRLPEQKEKLWE--HEKMQEQEKIWEQEEKMRDQEEKMRGQEE 808
Query: 623 KSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQ-RPRKLHEEEK 681
K E + ++E+ + EK + ++ + +K W + + E++ Q + K+ E+E+
Sbjct: 809 KMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE 868
Query: 682 LKREESVKKKDGEEK--GKQE 700
R + K ++ EEK G++E
Sbjct: 869 KMRGQEEKMREQEEKMRGQEE 889
Score = 94.4 bits (233), Expect = 9e-19
Identities = 86/388 (22%), Positives = 183/388 (47%), Gaps = 40/388 (10%)
Query: 359 ERGNLELEKRRQALLEQQ--RKEQERLAQLERAEQERKERERQEQERKRQLE-------- 408
ER L LE R + ++ +K E +L AE E+ E + +E KR+LE
Sbjct: 205 ERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQ 264
Query: 409 -----LEKQLEKQRELERQREEERRKEIE---RREAAKRELE----RQRQLEWERNRRQE 456
L++++ +Q E R++E++ RK+ E R+E RE E Q + W + +R
Sbjct: 265 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLR 324
Query: 457 LLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQ-------- 508
+ +EQE + + + + E +++ +K + E K+++ ++ Q +
Sbjct: 325 EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384
Query: 509 --EIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLV 566
E E + +E R+ E ++ +E + ++ + + + ++ K +Q RD
Sbjct: 385 MREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEE 444
Query: 567 TLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSME 626
++ +E ++ ++ E+E + + QE +++ + KE ++ Q+L +QK
Sbjct: 445 KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ----QRLPEQKEKL 500
Query: 627 AERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREE 686
E+ K +EQE KI E E++ + + + K W + +E E Q + E+E+ R++
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ----MWEQEEKMRDQ 556
Query: 687 SVKKKDGEEKGKQEAQDKLGRLFHQHQE 714
K D EE+ +++ Q++ + + Q ++
Sbjct: 557 EQKMWDQEERMEKKTQEQEKKTWDQEEK 584
Score = 69.7 bits (169), Expect = 2e-11
Identities = 76/322 (23%), Positives = 157/322 (48%), Gaps = 35/322 (10%)
Query: 440 ELERQRQ---LEWERNR-RQELLNQRNKE-QEDIVVLKAKKKTLEFELEALNDKKHQLEG 494
EL ++R LE RN E L ++N E QE + + +++K ++ ++ L K + +
Sbjct: 201 ELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKF 260
Query: 495 KLQDIRCRLTTQ---RQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQ 551
L ++ + RQE E + +++R E + +Q + ++ G++ +++ + Q
Sbjct: 261 LLPQVQTNTLQEEMWRQEEELREQEKKIRKQE-EKMWRQEERLREQEGKMREQEEKMWRQ 319
Query: 552 LKQVQQNSLH-RDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNN----- 605
K++++ R+ L+ E +E Q + E+E + + QE ++
Sbjct: 320 EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
Query: 606 -QLKELREIHNKQQLQKQKSMEA-ERLKQKE-----QERKIIELEKQKEEAQRRAQERDK 658
Q K++RE K + Q+++ E ERL++KE QE+ ++EK +EE + + QE+
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 659 QWLEHVQQEDEH--QRPRKLHEEEKL---------KREESVKKKDGEEKGKQEAQDKLGR 707
+ E QE+E +R +K+ EEE+ K+EE++ +++ +E +Q ++ +
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499
Query: 708 LFHQHQEPAKPAVQAPWSTAEK 729
L+ QE + + W EK
Sbjct: 500 LW--EQEKMQEQEEKIWEQEEK 519
Score = 55.5 bits (132), Expect = 5e-07
Identities = 68/333 (20%), Positives = 146/333 (43%), Gaps = 54/333 (16%)
Query: 414 EKQRELERQREEERRKEIERREAAKRELERQ----RQLEWERNRRQELL----------- 458
E ++ Q +EE++ + +EA +RE+E Q R L ++ + L
Sbjct: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
Query: 459 --NQRNKEQEDIVVLKA---------KKKTLEFELEALNDKKH---QLEGKLQDIRCRLT 504
N ++ + +A + E + L + H G+LQ ++
Sbjct: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
Query: 505 TQRQE----IESTNKSRELRIAEI-------THLQQQLQESQQMLGRLIPEKQILNDQLK 553
T+ ++ IE K R+ E+ L+++ E Q+ L EK + +K
Sbjct: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVK 249
Query: 554 QVQQNSLHRDSLV------TLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQL 607
++++ L+ TL+ + +E + LR+Q ++ K+ ++ + Q
Sbjct: 250 ELKRKLERAKFLLPQVQTNTLQEEMWRQE---EELREQEKKIRKQEEKMWRQEERLREQE 306
Query: 608 KELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLE----H 663
++RE K Q+++ E E+ + +EQE+++ E ++ +E+ ++ ++ +K W +
Sbjct: 307 GKMREQEEKMWRQEKRLREQEK-ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMR 365
Query: 664 VQQEDEHQRPRKLHEEEKLKREESVKKKDGEEK 696
Q+E ++ +L E+EK RE+ K +D EE+
Sbjct: 366 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 114 bits (285), Expect = 8e-25
Identities = 104/424 (24%), Positives = 198/424 (46%), Gaps = 26/424 (6%)
Query: 336 EDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQR-KEQERLAQLERAEQERK 394
++ +++ EK+ D+KRE R + ++R E+QR +E+ER Q +R ++
Sbjct: 60 KERERRREKRQTERETDRKRER--RREKDRHRKRDRHRERQRDREKERERQTDRERDRQR 117
Query: 395 ERERQEQ-ERKRQLELE------KQLEKQRELERQREEERRKEIERREAAKRELERQRQL 447
E+ER Q ER+R+ E E +Q + QRE ERQR+ E+ +E + +R+ ER RQ
Sbjct: 118 EKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQK 177
Query: 448 EWERNR----RQELLNQRNKEQ--EDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRC 501
E ER + R+E QR KE ED + +++ E E E ++K Q + + R
Sbjct: 178 EREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD--RQ 235
Query: 502 RLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLH 561
R T + +E ++ + R E +++ ++ + R E++ D+ + Q
Sbjct: 236 RKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKR---QRRTE 292
Query: 562 RDSLVTLKRALE-----AKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNK 616
RD KR + +E R+ R++ E E+E + + + + K R+
Sbjct: 293 RDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMD 352
Query: 617 QQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKL 676
++ +Q E R ++E+ER+ + E + R ++RD+ + +++ E R +
Sbjct: 353 RERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 677 HEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISA 736
E++ +RE+ + + G E+G++ + K + Q + Q ST P +A
Sbjct: 413 ETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTA 472
Query: 737 QENV 740
+ V
Sbjct: 473 RSGV 476
Score = 103 bits (257), Expect = 1e-21
Identities = 81/375 (21%), Positives = 183/375 (48%), Gaps = 20/375 (5%)
Query: 344 KKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQER 403
++ P + E +R + + + + + Q+ +E+ R + E +RK R+E++R
Sbjct: 28 RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDR 87
Query: 404 KRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNK 463
R+ + ++ ++ RE ER+R+ +R ++ +R + R+ ER+R+ E E R ++ +
Sbjct: 88 HRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQR 147
Query: 464 EQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAE 523
E+E + + E E + +++ Q E Q R R RQE + RE
Sbjct: 148 ERE-----RQRDAEKERERQTDRERQRQTERNRQKERER-EKNRQERRERERQRE----- 196
Query: 524 ITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLR 583
+ + ++ GR ++ + ++ +Q RD +R E K+ R+
Sbjct: 197 ---KENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERERE-KQAERERAS 252
Query: 584 DQLDEVEKE-TRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIEL 642
++ E +KE R + ++ D Q + R+ K+Q + ++ E ER +++++ER+ E
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE-RER 311
Query: 643 EKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQ 702
E+ ++ + R +ER+++ +++ E +R RK + ++ RE + ++ G E G+++A+
Sbjct: 312 ERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERN--RQTGRE-GRRQAE 368
Query: 703 DKLGRLFHQHQEPAK 717
+ R + ++ A+
Sbjct: 369 RERERERERDRQSAR 383
Score = 60.8 bits (146), Expect = 1e-08
Identities = 60/297 (20%), Positives = 133/297 (44%), Gaps = 11/297 (3%)
Query: 407 LELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQE 466
+E+ L+ R +E RR+ + + +R+R + ER RR+E K Q
Sbjct: 18 VEVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRRE------KRQT 71
Query: 467 DIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLT-TQRQEIESTNKSRELRIAEIT 525
+ + +++ E + D+ + + + R R T +R ++R+ T
Sbjct: 72 ERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERET 131
Query: 526 HLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQ 585
+ + +Q G+ E+Q ++ ++ Q + + ++ +E RQ R++
Sbjct: 132 EREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRER 191
Query: 586 LDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQ 645
+ EKE +++ + + + +E RE + + ++Q E +R ++ E+ER E + +
Sbjct: 192 ERQREKENKTEDRHSERGRERERE-RETETETERKRQTDRERDRQRKTERER---EKQAE 247
Query: 646 KEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQ 702
+E A R ERDK+ ++ + R +K E + ++ + ++D E + K+E Q
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQ 304
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 114 bits (284), Expect = 1e-24
Identities = 87/331 (26%), Positives = 153/331 (46%), Gaps = 42/331 (12%)
Query: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIR 974
++A + ++A+ D+ L + ++IT + ++D WW G++ G++G FP ++V+ I ++
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMK 61
Query: 975 KSTSMDSGSSESPASLKRVASPAAKPVVSGEEFI--------------AMYTYESSEQGD 1020
K + + + E P L V P+ ++S E + ++Y +
Sbjct: 62 KD-PLTNKAPEKP--LHEV--PSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDE 116
Query: 1021 LTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIA 1079
L + GD+I +V + + WW G + K G+FPSN+++ E K +
Sbjct: 117 LELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLR 176
Query: 1080 QVIASYTATGPEQLTLAPG-----QLILIRKKNPGGWWEGE--------LQARGKKRQIG 1126
+ S + G T + G I+ K G G+ L+ R + +
Sbjct: 177 ETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVEND 236
Query: 1127 WFPANYV---KL-LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQII 1182
+ P KL + T + TE T C+VI + Y AQNDDEL +G I+
Sbjct: 237 FLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQNDDELTIKEGDIV 294
Query: 1183 NVLNKE--DPDWWKGEVNGQVGLFPSNYVKL 1211
++NK+ D WW+GE+NG+ G+FP N+VKL
Sbjct: 295 TLINKDCIDVGWWEGELNGRRGVFPDNFVKL 325
Score = 80.1 bits (196), Expect = 2e-14
Identities = 95/432 (21%), Positives = 159/432 (36%), Gaps = 121/432 (28%)
Query: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENE 808
+ ++++ DE+TI G+I+ + + GW G++ G+ G FP N+ +I +
Sbjct: 8 FDYQAQHDDELTISVGEIIT-------NIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
Query: 809 VPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETD 868
P+ TN+ PE
Sbjct: 61 KKDPL-----------------------------------------------TNKAPE-- 71
Query: 869 NWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKK 928
+P VPS L G + Q + + +
Sbjct: 72 -------KPLHEVPSGNSLLSSETILRTNKRGER-----------RRRRCQVAFSYLPQN 113
Query: 929 DNHLNFNKNDVITVL-EQQDMWWFGEVQGQKGWFPKSYVKLISGP--------------- 972
D+ L D+I V+ E ++ WW G + G+ G FP +++K +SG
Sbjct: 114 DDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKS 173
Query: 973 -IRKSTSM-----DSGSSESPASLKRVASPAAKPV-VSGEEFIAMYTYESSEQGDLTFQQ 1025
+R++T DS S++S + VA+ A +P V G F ++ + + + +
Sbjct: 174 SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEV 233
Query: 1026 GDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASY 1085
+ L +K T+G K + K S T K + +VI Y
Sbjct: 234 ENDFLPVEK-------TIGKKLPATTATPDSSKTEMDSRTKSK--------DYCKVIFPY 278
Query: 1086 TATGPEQLTLAPGQLILIRKKN--PGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSK- 1142
A ++LT+ G ++ + K+ GWWEGEL R G FP N+VKLL P K
Sbjct: 279 EAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR-----GVFPDNFVKLLPPDFEKE 333
Query: 1143 -ITPTEPPKSTA 1153
P +PP +A
Sbjct: 334 GNRPKKPPPPSA 345
Score = 54.3 bits (129), Expect = 1e-06
Identities = 47/167 (28%), Positives = 71/167 (42%), Gaps = 30/167 (17%)
Query: 744 YYRALYPFESRSHDEITIQPGDIV-MVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
Y + ++P+E+++ DE+TI+ GDIV ++ + +D GW GEL G+ G FP N+ +
Sbjct: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCID------VGWWEGELNGRRGVFPDNFVK 324
Query: 803 KIP---ENEVPAPVKPVTDSTSAPAPKLALRETPAP---LAVTSSEPSTTPNNWADFSST 856
+P E E P KP SAP K T + P PN
Sbjct: 325 LLPPDFEKEGNRPKKP--PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNR------- 375
Query: 857 WPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSP 903
T E+PE + + L PS + + P T + S P
Sbjct: 376 --TEEKERPERE------PKLDLQKPSVPAIPPKKPRPPKTNSLSRP 414
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 112 bits (279), Expect = 4e-24
Identities = 105/424 (24%), Positives = 216/424 (50%), Gaps = 49/424 (11%)
Query: 312 RSGSGISVISSTSVDQRLPEEPVLEDEQQQL----EKKLPVTFEDKKRENFERGNLELEK 367
R + + +T D+ L E+ E+ QL + ++ + ++ KR+ ER L L +
Sbjct: 202 RDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK-LERAKLLLPQ 260
Query: 368 RR---------------QALLEQQRKEQE---RLAQLERAEQERKERERQEQERKRQLEL 409
++ A L+ Q +E E RL Q + + R+E + QE E K Q E
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ-EQ 319
Query: 410 EKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERN---RRQELL----NQRN 462
E+++ +Q E R++EE+ R++ E + ++ RQ ++ WE+ RRQE + ++
Sbjct: 320 EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 379
Query: 463 KEQEDIVVLKAKK-KTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRI 521
+ QE+++ K +K + LE ++ + Q E + ++ + R +RQE E+ +E +I
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 439
Query: 522 AEITHLQQQLQESQQMLGRL---IPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELA 578
E +++++E ++ + R I E++ + ++ K+ +Q + R ++ E +E+
Sbjct: 440 RE---QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE----EKIHEQEEIW 492
Query: 579 RQH--LRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQE 636
RQ + +Q +++ K+ ++ + Q +++RE K Q++K E E + ++E+
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEE- 551
Query: 637 RKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEK 696
K+ E EK EE +R+ QE DK W + +++ Q + +EEK++ +E +++ E+
Sbjct: 552 -KMHEQEKIWEEEKRQEQE-DKMWRQ--EEKIREQEEKVWRQEEKIREQEEKRQEQEEKM 607
Query: 697 GKQE 700
KQE
Sbjct: 608 WKQE 611
Score = 106 bits (264), Expect = 2e-22
Identities = 82/406 (20%), Positives = 205/406 (50%), Gaps = 27/406 (6%)
Query: 328 RLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLE 387
R EE + E E++ ++ + +++K E E E++ + E +++E++ + E
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 383
Query: 388 RAEQERKERERQEQERKRQLE-LEKQLEKQRELERQREEERRKE-----------IERRE 435
E++E+ R+ +E+ + E + +Q EK++E E+ RE+E+R+E I +E
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 443
Query: 436 AAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFE-LEALNDKKHQLEG 494
RE E++ + E+ QE + + K QE + + ++K E E + +K H+ E
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Query: 495 KLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLG---RLIPEKQILNDQ 551
K++ ++ Q ++I + + ++ +++++E ++M ++ +++I ++
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE 563
Query: 552 LKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELR 611
+Q Q++ + R ++ E + +R+Q ++ +++ ++ + Q ++++
Sbjct: 564 KRQEQEDKMWRQE-EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ 622
Query: 612 EIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQ 671
E K + Q++K E E + Q+++E+ + EK E+ ++ ++ + W + + ++ +
Sbjct: 623 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Query: 672 RPR----KLHEEEKLKREESVKKKDGEEK------GKQEAQDKLGR 707
+ R K+ E+E++ +E+ K + EEK QE ++K+ R
Sbjct: 683 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 728
Score = 103 bits (256), Expect = 2e-21
Identities = 83/377 (22%), Positives = 193/377 (51%), Gaps = 12/377 (3%)
Query: 331 EEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQA-LLEQQRKEQERLAQLERA 389
EE + E+ EK+ + ++K E+ + EKR++ + +Q K QE+ A++ R
Sbjct: 376 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR- 434
Query: 390 EQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEW 449
QE K RE++E+ R+++ ++ +Q EK E E+ REEE+R+E E + ++ Q ++
Sbjct: 435 -QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493
Query: 450 ERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQD----IRCRLTT 505
++ + E + K++E + + K + E ++ +K + E K+++ R
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKM 553
Query: 506 QRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSL 565
QE + R+ + ++ +++++E ++ + R E++I + K+ +Q
Sbjct: 554 HEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR--QEEKIREQEEKRQEQEEKMWKQE 611
Query: 566 VTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSM 625
++ E + + +R+Q +++ ++ ++ + Q +++ E K Q +++++M
Sbjct: 612 EKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ-EQEETM 670
Query: 626 EAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685
+ K +EQE+KI E E++ E + QE++++ E Q+E ++ K+ E+E+ R
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE--QEEKMCEQEEKMQEQEEKMRR 728
Query: 686 ESVKKKDGEEKGKQEAQ 702
+ K + E + +Q+ +
Sbjct: 729 QEEKMWEQEVRLRQQEE 745
Score = 90.5 bits (223), Expect = 1e-17
Identities = 80/341 (23%), Positives = 165/341 (48%), Gaps = 34/341 (9%)
Query: 331 EEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAE 390
EE + E E++ E++ + +++K E+ + E++RQ E R+E++ Q E
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEK--IREEEKRQEQEEMWRQEEKIHEQEEIWR 493
Query: 391 QERKERERQEQERKRQLELEKQLEKQRELERQREEERRK------EIERREAAKRELERQ 444
Q+ K E++E+ RK++ ++ +Q EK RE E + E+ K +I +E RE E+
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKM 553
Query: 445 RQLE--WERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCR 502
+ E WE +RQE ++ +++E I + K E ++ +K+ + E K+ +
Sbjct: 554 HEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEK 613
Query: 503 LTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHR 562
+ Q ++I+ + + +I ++ QE ++ +G EK ++ Q Q+ ++ R
Sbjct: 614 IREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ-EEKMCEQEEKMQEQEETMWR 672
Query: 563 DSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQ 622
+++ E EK+ R + ++I Q + ++E K Q++
Sbjct: 673 QE-------------------EKIREQEKKIREQEEKI---REQEEMMQEQEEKMWEQEE 710
Query: 623 KSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEH 663
K E E K +EQE K+ E++ E + R ++++++ EH
Sbjct: 711 KMCEQEE-KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
Score = 78.6 bits (192), Expect = 5e-14
Identities = 105/474 (22%), Positives = 208/474 (43%), Gaps = 42/474 (8%)
Query: 294 PLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQ---LEKKLPVTF 350
P P LP P+ + + + LP P++ E +Q E K +T
Sbjct: 10 PTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAKEQLT- 68
Query: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE 410
+ + N G + +++ + E E E+K + ++ +R ELE
Sbjct: 69 DHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRR--ELE 126
Query: 411 KQLEKQRELERQREEER------RKEIERREAAKRELERQRQLEWERNRRQE-----LLN 459
Q+ R L Q+ E + + +++ E R+L + W+ E +
Sbjct: 127 AQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVAT 186
Query: 460 QRNKEQEDIVVLKAKKKTLEFEL-------EALNDKKHQLEGKLQDIRCRLTTQRQEIES 512
Q+ K I L ++ L EL E L +K +L+ KLQ + +++ EI+
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE----SEKSEIQL 242
Query: 513 TNKS--RELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLK-QVQQNSLHRDSLVTLK 569
K R+L A++ QQQLQ LG+ E Q ++ +L+ QV++N L +
Sbjct: 243 NVKELKRKLERAKLLLPQQQLQAEADHLGK---ELQSVSAKLQAQVEENELWNRLNQQQE 299
Query: 570 RALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAER 629
+ +E Q +++ E E++ R + ++I +++ E+ +++ +K + E
Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE-EKMRRQEEMM 358
Query: 630 LKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQ-EDEHQRPRKLHEEEKLKREESV 688
+++E+ R+ E+ +KEE RR +E + E +++ E++ K+ E+E+ KR+E
Sbjct: 359 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE-KRQEEE 417
Query: 689 KKKDGEEKGKQEAQD-KLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVK 741
K ++ E++ +QEA+ + + +E + + W EK I QE ++
Sbjct: 418 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK----IHEQEKIR 467
Score = 56.6 bits (135), Expect = 2e-07
Identities = 58/223 (26%), Positives = 113/223 (50%), Gaps = 22/223 (9%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQ 385
++++ E+ + E++++ ++ + E+K++E ++ + EK R+ + R+E++ Q
Sbjct: 537 EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQ 596
Query: 386 LE-RAEQERK----ERERQEQERKRQLELEK---QLEKQRELERQREEERRKEIERREAA 437
E R EQE K E + +EQE K Q + EK Q EK RE E +E+ K E+ E
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 656
Query: 438 KRELERQRQLEWERNRRQELLNQRNK---EQEDIVVLKAKKKTLEFELEALNDKKHQLEG 494
+ E+ ++ E R++E + ++ K EQE+ K + E ++ +K + E
Sbjct: 657 CEQEEKMQEQEETMWRQEEKIREQEKKIREQEE------KIREQEEMMQEQEEKMWEQEE 710
Query: 495 KLQDIRCRLTTQRQEIESTNKSRELRIAE-ITHLQQQLQESQQ 536
K+ C + QE E + +E ++ E L+QQ ++ Q+
Sbjct: 711 KM----CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 111 bits (277), Expect = 7e-24
Identities = 96/404 (23%), Positives = 216/404 (53%), Gaps = 36/404 (8%)
Query: 336 EDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKE 395
E+E ++ EKK+ +K+E ++ ++ + L EQ+ K +E+ ++ R E+ +E
Sbjct: 240 EEELREQEKKI------RKQEE------KMWRQEERLREQEGKMREQEEKMRRQEKRLRE 287
Query: 396 RERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQ 455
+E++ +E++++L +K+L +Q E +++EE+ ++ E+ + ++ RQ + WE+ ++
Sbjct: 288 QEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 347
Query: 456 ELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQD---IRCRLTTQRQEIES 512
Q+ ++QE+ + + ++ + E +K + E K+Q+ IR R R+E E+
Sbjct: 348 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEET 407
Query: 513 TNKSRE-LRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKR- 570
+ E ++ E +Q+ +E QQ RL +K+ L +Q K +Q + ++
Sbjct: 408 MREQEEKMQKQEENMWEQEEKEWQQQ--RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465
Query: 571 ----ALEAKELARQHLRDQLDEV-EKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSM 625
E K ++ +R+Q D++ E+E + + QE +++ +E R ++L++++
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD---QEERMWEQDERLREKEER 522
Query: 626 EAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685
E+ K +QE K+ E EK+ +E +++ +++++ E +E +R +K+ EEE++ RE
Sbjct: 523 MREQKKMWQQEEKMRE-EKKTQEQEKKTWDQEEKMRE---EERMREREKKMREEEEMMRE 578
Query: 686 ESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK 729
+ K ++ EEK +E ++K+ + +E + + W EK
Sbjct: 579 QEEKMQEQEEK-MREQEEKM----WEQEEKMQEQEEKMWEQEEK 617
Score = 110 bits (275), Expect = 1e-23
Identities = 101/424 (23%), Positives = 218/424 (51%), Gaps = 29/424 (6%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQE-RLA 384
++ L E+ L ++++Q++++ +E +++ + + ++ R E+Q +EQE ++
Sbjct: 296 EKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR 355
Query: 385 QLERAEQERKERERQEQERKRQLE-LEKQLEKQRELERQREEER--RKEIERREAAKREL 441
E E+ ER R+++ER R+ E + +Q EK +E ER RE E+ R+E E + ++
Sbjct: 356 DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKM 415
Query: 442 ERQRQLEWERN----RRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQ 497
++Q + WE+ ++Q L Q+ K E + + ++K E E E + D++ ++ G+ +
Sbjct: 416 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE-EKIRDQE-EMWGQEK 473
Query: 498 DIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQ 557
+ + + QE + + ++R E + Q + + RL +++ + +Q K QQ
Sbjct: 474 KMWRQEKMREQEDQMWEQEEKMRDQE-QKMWDQEERMWEQDERLREKEERMREQKKMWQQ 532
Query: 558 NSLHRDSLVTL---KRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIH 614
R+ T K+ + +E R+ +++ E EK+ R +E ++ Q ++++E
Sbjct: 533 EEKMREEKKTQEQEKKTWDQEEKMRE--EERMREREKKMR---EEEEMMREQEEKMQEQE 587
Query: 615 NKQQLQKQKSMEAERLKQKEQERKIIELEK---QKEEAQRRAQERDKQW--LEHVQQEDE 669
K + Q++K E E K +EQE K+ E E+ ++EE + ++ + W E +Q+++E
Sbjct: 588 EKMREQEEKMWEQEE-KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEE 646
Query: 670 H--QRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGR--LFHQHQEPAKPAVQAPWS 725
++ K+ E+E+ RE+ K + EEK +++ + G+ + +E + + W
Sbjct: 647 KMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWG 706
Query: 726 TAEK 729
EK
Sbjct: 707 QEEK 710
Score = 100 bits (250), Expect = 9e-21
Identities = 83/440 (18%), Positives = 224/440 (50%), Gaps = 41/440 (9%)
Query: 319 VISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRK 378
V ++T ++ +E L ++++++ K+ + ++R + G + ++ + E++ +
Sbjct: 227 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR 286
Query: 379 EQER--------LAQLERAEQERKERERQEQE--------RKRQLELEKQLEKQRELERQ 422
EQE+ L + ++ ++ ++ + QE++ R+++ ++ +Q E+ E E+Q
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 423 REEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFEL 482
E+ +K ++ E + ER R+ E ER R QE + ++ ++ ++ ++ ++K + E
Sbjct: 347 MREQEQKMRDQEERMWEQDERLREKE-ERMREQEKMWEQEEKMQEEERIREREKKMREEE 405
Query: 483 EALNDKKHQLEGKLQDI---------RCRLTTQRQEIESTNKSRELRIAEITHLQQQLQE 533
E + +++ +++ + +++ + RL Q++++ K +E + +I ++++++
Sbjct: 406 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE-QEEKIWEQEEKIRD 464
Query: 534 SQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKET 593
++M G+ EK++ + + Q++ + R E K ++ + DE +E
Sbjct: 465 QEEMWGQ---EKKMWRQEKMREQEDQMWEQE--EKMRDQEQKMWDQEERMWEQDERLREK 519
Query: 594 RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQ----KEQERKIIELEKQKEEA 649
+++E Q +++RE Q+ +K+ + E++++ +E+E+K+ E E+ E
Sbjct: 520 EERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ 579
Query: 650 QRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLF 709
+ + QE++++ E Q+E ++ K+ E+E+ E+ K + EE+ K + Q++ +
Sbjct: 580 EEKMQEQEEKMRE--QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE---MM 634
Query: 710 HQHQEPAKPAVQAPWSTAEK 729
+ +E + + W EK
Sbjct: 635 WEQEEKMQEQEEKMWEQEEK 654
Score = 95.9 bits (237), Expect = 3e-19
Identities = 96/438 (21%), Positives = 202/438 (46%), Gaps = 55/438 (12%)
Query: 331 EEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERA- 389
EE + E E++ ++ + ++K+ E+ + E+R E+ R+++ER+ + E+
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Query: 390 -EQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLE 448
++E+ + E + +ER++++ E++ +++E + Q++EE E E +E ++ L Q++
Sbjct: 383 EQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 442
Query: 449 WERNRRQELLNQRNKEQEDI-----VVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRL 503
WE+ + QE + +++E I + + KK + ++ D+ + E K++D ++
Sbjct: 443 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 502
Query: 504 TTQRQ---EIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSL 560
Q + E + + +E R+ E + QQ ++ ++ EK+ + + K ++ +
Sbjct: 503 WDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERM 562
Query: 561 HRDSLVTLKRALEAKELARQHLRDQLDEVEK---------ETRSKLQEI----------- 600
K+ E +E+ R+ ++ EK E K+QE
Sbjct: 563 RERE----KKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKM 618
Query: 601 ------DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEK--QKEEAQRR 652
D Q + + E K Q Q++K E E K +EQE K+ E E+ Q +E + R
Sbjct: 619 WEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEE-KMREQEEKMREQEEKMQGQEEKMR 677
Query: 653 AQERDKQWLEHVQQEDEH-----------QRPRKLHEEEKLKREESVKKKDGEEKG-KQE 700
QE Q E +E E Q + +EEK+ +E +++K+ + K++
Sbjct: 678 EQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEK 737
Query: 701 AQDKLGRLFHQHQEPAKP 718
Q++L + EP P
Sbjct: 738 MQERLPEHEERCSEPCLP 755
Score = 95.5 bits (236), Expect = 4e-19
Identities = 84/351 (23%), Positives = 170/351 (48%), Gaps = 22/351 (6%)
Query: 359 ERGNLELEKRRQALLEQQ--RKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQ 416
ER L LE R + ++ +K E +L AE E+ E + +E KR+LE K L Q
Sbjct: 167 ERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQ 226
Query: 417 RELERQREEERRKEIERREAAKRELERQRQLEW---ERNRRQE--LLNQRNKEQEDIVVL 471
+ +EE R+E E RE K+ + +Q + W ER R QE + Q K + L
Sbjct: 227 VQTNTLQEEMWRQEEELREQEKK-IRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRL 285
Query: 472 KAKKKTLEFELEALNDKK--HQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQ 529
+ ++K L + + L ++K + E ++Q+ ++ Q +++ + + + ++
Sbjct: 286 REQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 345
Query: 530 QLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEV 589
Q++E +Q + +++L++ ++ ++ + + ++ +E R+ + +E
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEE 405
Query: 590 ----EKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQ 645
E+E + + QE +++ + KE ++ Q+L +QK E+ K +EQE KI E E++
Sbjct: 406 ETMREQEEKMQKQEENMWEQEEKEWQQ----QRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
Query: 646 KEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEK 696
+ + + K W + +E E Q + E+E+ R++ K D EE+
Sbjct: 462 IRDQEEMWGQEKKMWRQEKMREQEDQ----MWEQEEKMRDQEQKMWDQEER 508
Score = 95.5 bits (236), Expect = 4e-19
Identities = 86/429 (20%), Positives = 206/429 (48%), Gaps = 44/429 (10%)
Query: 335 LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERK 394
L+ + +L++KL + +K L+ + R L Q + ++ R E+E +
Sbjct: 185 LKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELR 244
Query: 395 ERERQ--EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWE-- 450
E+E++ +QE K + E+ E++ ++ Q E+ RR+E RE K E++++L +
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK 304
Query: 451 -RNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQL---EGKLQDIRCRLTTQ 506
R + +++ Q K E ++ +++ + + E L +++ Q+ E K++D R+ Q
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 364
Query: 507 RQEI-ESTNKSRELRIAEITHLQQQLQESQQMLGR---LIPEKQILNDQLKQVQQNSLHR 562
+ + E + RE ++ ++++QE +++ R + E++ + +Q +++Q+ +
Sbjct: 365 DERLREKEERMREQE--KMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN- 421
Query: 563 DSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLK-------------- 608
E KE +Q L +Q +++ ++ + + QE I+ + K
Sbjct: 422 ------MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 475
Query: 609 ----ELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHV 664
++RE ++ Q++K + E+ K +QE ++ E +++ E + R +E+ K W +
Sbjct: 476 WRQEKMREQEDQMWEQEEKMRDQEQ-KMWDQEERMWEQDERLREKEERMREQKKMWQQEE 534
Query: 665 QQEDE----HQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
+ +E Q + +EEK++ EE +++++ + + ++E + + +E +
Sbjct: 535 KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594
Query: 721 QAPWSTAEK 729
+ W EK
Sbjct: 595 EKMWEQEEK 603
Score = 62.8 bits (151), Expect = 3e-09
Identities = 66/303 (21%), Positives = 139/303 (45%), Gaps = 42/303 (13%)
Query: 424 EEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELE 483
E+E++ + +EA +RE+E Q + +L + E E + ++ +FE
Sbjct: 70 EDEKKASHQHQEALRREIEAQ-------DHTIRILTCQKTELE-TALYYSQDAARKFEDG 121
Query: 484 ALNDKKH---------QLEGKLQDIRCRLTTQRQE----IESTNKSRELRIAEI------ 524
L + K G+LQ ++T ++ IE K R+ E+
Sbjct: 122 NLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTIT 181
Query: 525 -THLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLV------TLKRALEAKEL 577
L+++ E Q+ L EK + +K++++ L+ TL+ + +E
Sbjct: 182 NEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE- 240
Query: 578 ARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQER 637
+ LR+Q ++ K+ ++ + Q ++RE K + Q+++ E E+ + +EQE+
Sbjct: 241 --EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK-ELREQEK 297
Query: 638 KIIELEKQKEEAQRRAQERDKQWLE----HVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693
++ E +K +E+ ++ ++ +K W + Q+E ++ +L E+EK RE+ K +D
Sbjct: 298 ELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 357
Query: 694 EEK 696
EE+
Sbjct: 358 EER 360
Score = 59.3 bits (142), Expect = 3e-08
Identities = 44/240 (18%), Positives = 124/240 (51%), Gaps = 13/240 (5%)
Query: 326 DQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQ 385
D+RL E+ EQ+++ ++ E+KK + E+ + E++ + + +E++ +
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Query: 386 LERAEQERKERERQEQERKRQLE-LEKQLEKQRELERQREEERRKEIERREAAKRELERQ 444
E ++ ++ + QE++ + Q E + +Q EK +E E + E+ K E+ E K ++ Q
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDK--MQEQ 630
Query: 445 RQLEWERNRR-----QELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDI 499
++ WE+ + +++ Q K +E ++ +++ ++ + E + +++ +++G+ + +
Sbjct: 631 EEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKM 690
Query: 500 RCRLTTQRQEIESTNKSRELRIAEITHL--QQQLQESQQMLGRLIPEKQILNDQLKQVQQ 557
R + R + E E + + Q++++E ++ R+ +K+ + ++L + ++
Sbjct: 691 REQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEE---RIRDQKEKMQERLPEHEE 747
Score = 41.2 bits (95), Expect = 0.009
Identities = 55/224 (24%), Positives = 103/224 (45%), Gaps = 32/224 (14%)
Query: 507 RQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLV 566
R+EIE+ + + + + T L+ L SQ + + L +S H
Sbjct: 84 RREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAG-- 141
Query: 567 TLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSME 626
L+RAL A + ++E+ KE R L ++++ N + ++L+K+ +
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKE-RDALS-LELYRNTI-------TNEELKKKNAEL 192
Query: 627 AERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQ----QEDEHQRPRKLHEEEK- 681
E+L+ E E+ I+L ++ +R ER K L VQ QE+ ++ +L E+EK
Sbjct: 193 QEKLRLAESEKSEIQLNVKE---LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKK 249
Query: 682 --------LKREESVKKKDG---EEKGKQEAQDKLGRLFHQHQE 714
++EE +++++G E++ K Q+K RL Q +E
Sbjct: 250 IRKQEEKMWRQEERLREQEGKMREQEEKMRRQEK--RLREQEKE 291
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 111 bits (277), Expect = 7e-24
Identities = 110/418 (26%), Positives = 200/418 (47%), Gaps = 43/418 (10%)
Query: 318 SVISSTSVDQRLPEEPVLEDEQQQLEKKLP----VTFEDKKRENFERGNLELEKRRQALL 373
+V+ S Q EEP E+E++Q ++ + EDK+R ER LE E+R +
Sbjct: 223 TVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282
Query: 374 EQQRKEQERLAQLERAE----QERKERERQEQERKRQLELEKQLEKQRELERQREEERRK 429
EQ +K + A++E E QER+ RE +E+ER R E EK+ ++R+ R +EEE+R
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMR--EEEKRAAEERQ--RIKEEEKRA 338
Query: 430 EIERREAAKREL----ERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKK-KTLEFELEA 484
ER+ + E ERQR E E+ +E R +E+E V + K+ K LE + A
Sbjct: 339 AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHA 398
Query: 485 LNDKKHQLEGKLQDIRCRLTTQRQEIES------TNKSRELRIAEITHLQQQLQESQQML 538
+ + K + E Q I + +++ E K E + ++ +++LQE +
Sbjct: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP-- 456
Query: 539 GRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRAL-EAKELARQHLRDQLDEVEKETRSKL 597
+++I ++++K+ ++ S + K+ E K + + +L E
Sbjct: 457 --TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPG 514
Query: 598 QEIDIFNNQLKELREIHNKQQLQ-------KQKSMEAERLKQKEQERKIIELEKQKEEAQ 650
+ + + ++ ++L+ + +S E E+LKQK+QE + + EE +
Sbjct: 515 GRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAAL-----ELEELK 569
Query: 651 RRAQERDKQWLEHVQQEDEHQRPRKLHEEE---KLKREESVKKKDGEEKGKQEAQDKL 705
++ +ER K E Q+ + + RKL EEE +LK E ++ + EK ++ +D L
Sbjct: 570 KKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 627
Score = 79.3 bits (194), Expect = 3e-14
Identities = 98/435 (22%), Positives = 189/435 (43%), Gaps = 75/435 (17%)
Query: 356 ENFERGN-LELEKRRQALLEQQR------KEQERLAQLERAEQERKERERQEQERKRQLE 408
++FER L +KR + LE +R + E A ER + R+ER RQ+QE + +
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 409 LEKQLEKQRELERQREEER---------------------RKEIERREAAKRELERQRQL 447
+ Q+E + EE + R+E R++ + LERQ++
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 448 E------------------------WERNRRQELLNQRNKEQEDIVVLKAKKKT--LEFE 481
+ E+ + E +R + +E V K+ +K + E
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
Query: 482 LEALNDKKHQLEGKLQDIRCRLTTQRQEI----ESTNKSRELRIAEITHLQQQLQESQQM 537
DK+ + E + + R + + E+ ++T E + + + Q +E +Q
Sbjct: 182 ENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQE 241
Query: 538 LGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRA-LEAKELARQHLRDQLDEVEKETRSK 596
E++ +D++ ++ +RA LEA+E R+ ++ + D+ + R++
Sbjct: 242 -----EEREQGSDEISHHEKMEEEDKERAEAERARLEAEE--RERIKAEQDKKIADERAR 294
Query: 597 LQEIDIFNNQLKELREIHNKQQLQKQKSMEA-ERLKQKEQERKII-ELEKQKEEAQRRAQ 654
++ + Q +E RE ++++++++ A ER + KE+E++ E ++ KEE +R A+
Sbjct: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354
Query: 655 ERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQE 714
ER + E + +E QR R EEEK K EE + K EEK + K+ E
Sbjct: 355 ERQRIKEEEKRAAEERQRAR-AEEEEKAKVEEQKRNKQLEEKKHAMQETKI------KGE 407
Query: 715 PAKPAVQAPWSTAEK 729
+ ++ W +K
Sbjct: 408 KVEQKIEGKWVNEKK 422
Score = 76.6 bits (187), Expect = 2e-13
Identities = 82/372 (22%), Positives = 168/372 (45%), Gaps = 63/372 (16%)
Query: 356 ENFERGNLELEKRRQALLEQQRKEQ-----------ERLAQLERAEQERKERERQEQERK 404
E R +KR Q LE+Q++ R Q + AE E E+E + + R+
Sbjct: 98 ERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ 157
Query: 405 RQLELEK--------QLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQE 456
+ E+E+ Q R+ E ++E++ KE E E KR + Q+E
Sbjct: 158 ERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE-------V 210
Query: 457 LLNQRNKE-QEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNK 515
++ ++ E QE+ VV+ K + E +++ Q ++ + +++E +K
Sbjct: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEI--------SHHEKMEEEDK 262
Query: 516 SRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAK 575
R AE + + +E +++ +K+I +++ + + K A + +
Sbjct: 263 ER----AEAERARLEAEERERIKAE--QDKKIADERARIEAEE----------KAAAQER 306
Query: 576 ELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEA-ERLKQKE 634
E R+++ E EK + Q I + +E R +Q++++++ A ER + KE
Sbjct: 307 ERREAEERERMREEEKRAAEERQRI-----KEEEKRAAEERQRIKEEEKRAAEERQRIKE 361
Query: 635 QERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGE 694
+E++ E E + RA+E +K +E ++ + + + +E K+K E+ +K +G+
Sbjct: 362 EEKRAAE-----ERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGK 416
Query: 695 EKGKQEAQ-DKL 705
+++AQ DKL
Sbjct: 417 WVNEKKAQEDKL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 38/115 (33%), Positives = 61/115 (53%), Gaps = 8/115 (6%)
Query: 378 KEQERLAQLE---RAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERR 434
KE E Q+E R E+ R+ R E E E EK +KQ+E + EE ++K ERR
Sbjct: 522 KEAEGAPQVEAGKRLEELRRRRGETESE-----EFEKLKQKQQEAALELEELKKKREERR 576
Query: 435 EAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKK 489
+ + E +R++Q E +R R+E +R KE+ + +A +K + + L+D K
Sbjct: 577 KVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
sapiens]
Length = 927
Score = 111 bits (277), Expect = 7e-24
Identities = 95/348 (27%), Positives = 168/348 (48%), Gaps = 16/348 (4%)
Query: 1228 LDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKE 1287
L L ++ KRQ I EL+VTE +V L+++ ++F +P+ E +E+ IF + E
Sbjct: 422 LHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDE 481
Query: 1288 LIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPY------IRFCSRQLNGAA 1341
LI + L L R++ SG ++ IGD+L A+ + RFCSRQ
Sbjct: 482 LIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALE 539
Query: 1342 LIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHP 1401
++ K + P F FV+ PRC+ + L I MQR+T+YPL++++I +NT E
Sbjct: 540 QLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT-EEPT 598
Query: 1402 DHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCL 1458
+ ++ A E E+ VN+ VR+ E+ RL+ Q + L S+ ++ +
Sbjct: 599 EREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDI 658
Query: 1459 GPRKFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-ITKPLGSSGTDKVFSPKSNLQYK 1514
+K +H G L ++ +K E++ L +D LLL Q + L + +P + +
Sbjct: 659 TKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTM 718
Query: 1515 MYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAW 1562
+ + + ++ TD +F ++Y L A++++ER W
Sbjct: 719 LRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNW 766
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
sapiens]
Length = 879
Score = 111 bits (277), Expect = 7e-24
Identities = 95/348 (27%), Positives = 168/348 (48%), Gaps = 16/348 (4%)
Query: 1228 LDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKE 1287
L L ++ KRQ I EL+VTE +V L+++ ++F +P+ E +E+ IF + E
Sbjct: 374 LHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDE 433
Query: 1288 LIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPY------IRFCSRQLNGAA 1341
LI + L L R++ SG ++ IGD+L A+ + RFCSRQ
Sbjct: 434 LIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALE 491
Query: 1342 LIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHP 1401
++ K + P F FV+ PRC+ + L I MQR+T+YPL++++I +NT E
Sbjct: 492 QLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT-EEPT 550
Query: 1402 DHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCL 1458
+ ++ A E E+ VN+ VR+ E+ RL+ Q + L S+ ++ +
Sbjct: 551 EREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDI 610
Query: 1459 GPRKFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-ITKPLGSSGTDKVFSPKSNLQYK 1514
+K +H G L ++ +K E++ L +D LLL Q + L + +P + +
Sbjct: 611 TKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTM 670
Query: 1515 MYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAW 1562
+ + + ++ TD +F ++Y L A++++ER W
Sbjct: 671 LRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNW 718
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
sapiens]
Length = 912
Score = 111 bits (277), Expect = 7e-24
Identities = 95/348 (27%), Positives = 168/348 (48%), Gaps = 16/348 (4%)
Query: 1228 LDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKE 1287
L L ++ KRQ I EL+VTE +V L+++ ++F +P+ E +E+ IF + E
Sbjct: 407 LHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDE 466
Query: 1288 LIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPY------IRFCSRQLNGAA 1341
LI + L L R++ SG ++ IGD+L A+ + RFCSRQ
Sbjct: 467 LIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALE 524
Query: 1342 LIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHP 1401
++ K + P F FV+ PRC+ + L I MQR+T+YPL++++I +NT E
Sbjct: 525 QLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT-EEPT 583
Query: 1402 DHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCL 1458
+ ++ A E E+ VN+ VR+ E+ RL+ Q + L S+ ++ +
Sbjct: 584 EREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDI 643
Query: 1459 GPRKFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-ITKPLGSSGTDKVFSPKSNLQYK 1514
+K +H G L ++ +K E++ L +D LLL Q + L + +P + +
Sbjct: 644 TKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTM 703
Query: 1515 MYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAW 1562
+ + + ++ TD +F ++Y L A++++ER W
Sbjct: 704 LRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNW 751
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 108 bits (271), Expect = 3e-23
Identities = 76/273 (27%), Positives = 132/273 (48%), Gaps = 9/273 (3%)
Query: 1224 DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFV 1283
+L +LD L+ ERKRQ + E++ +E +Y + L ++ E F + +T+ E +F
Sbjct: 271 ELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFS 330
Query: 1284 NWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLP-HMQPYIRFCSRQLNGAAL 1342
N +++ + + + L R K ++ V+ I DIL H PYI +CS ++
Sbjct: 331 NILDVLGASQRFFEDLEQRHKA---QVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRT 387
Query: 1343 IQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPD 1402
+Q+ F+E ++ + P C G+P+ SF++ PMQRVTR PL++ + T +
Sbjct: 388 LQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSER 447
Query: 1403 HSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRK 1462
+ AL+ +L Q NEG E +++ + + + + L S + L R
Sbjct: 448 YKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV-KSLPLISASRWLLKRG 506
Query: 1463 FL----HSGKLYKAKSNKELYGFLFNDFLLLTQ 1491
L +G K S Y FLFND L++T+
Sbjct: 507 ELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK 539
Score = 42.4 bits (98), Expect = 0.004
Identities = 20/68 (29%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGE--VQGQKGWFPKSY 965
G K + Q + + AK+ + + + DV+ VL+Q+D W +GE G+ GWFP+ +
Sbjct: 624 GLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPEDF 683
Query: 966 VKLISGPI 973
+ I+ +
Sbjct: 684 ARFITSRV 691
Score = 40.8 bits (94), Expect = 0.011
Identities = 22/56 (39%), Positives = 32/56 (57%), Gaps = 10/56 (17%)
Query: 751 FESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGEL--KGKTGWFPANYAEKI 804
F ++ DE+T+Q D+V+V + E GWL GE G+TGWFP ++A I
Sbjct: 640 FFAKQADEVTLQQADVVLVLQQ--------EDGWLYGERLRDGETGWFPEDFARFI 687
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,728,011
Number of Sequences: 37866
Number of extensions: 3649840
Number of successful extensions: 79147
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1277
Number of HSP's successfully gapped in prelim test: 1651
Number of HSP's that attempted gapping in prelim test: 17706
Number of HSP's gapped (non-prelim): 21248
length of query: 1721
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1605
effective length of database: 13,855,062
effective search space: 22237374510
effective search space used: 22237374510
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.