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Search of human proteins with 4758598
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758598 interleukin 1 receptor, type II precursor [Homo
sapiens]
(398 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27894334 interleukin 1 receptor, type II precursor [Homo sapi... 825 0.0
gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens] 825 0.0
gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens] 124 1e-28
gi|11225607 interleukin 1 receptor accessory protein-like 2 [Hom... 122 7e-28
gi|7657232 interleukin 1 receptor accessory protein-like 1 precu... 107 2e-23
gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens] 103 2e-22
gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [H... 95 1e-19
gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [H... 94 2e-19
gi|4504661 interleukin 1 receptor accessory protein isoform 1 [H... 92 1e-18
gi|19882209 interleukin 1 receptor accessory protein isoform 2 [... 92 1e-18
gi|4504657 interleukin 18 receptor accessory protein precursor [... 78 1e-14
gi|118572606 hemicentin 1 [Homo sapiens] 57 2e-08
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 55 1e-07
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 55 1e-07
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 55 1e-07
gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens] 52 7e-07
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 52 1e-06
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 50 3e-06
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 50 5e-06
gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor [... 50 5e-06
gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor [... 50 5e-06
gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor [... 50 5e-06
gi|110349719 titin isoform N2-A [Homo sapiens] 49 1e-05
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 48 1e-05
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 48 1e-05
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 48 1e-05
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens] 48 2e-05
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 48 2e-05
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens] 48 2e-05
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 48 2e-05
>gi|27894334 interleukin 1 receptor, type II precursor [Homo
sapiens]
Length = 398
Score = 825 bits (2130), Expect = 0.0
Identities = 398/398 (100%), Positives = 398/398 (100%)
Query: 1 MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWAS 60
MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWAS
Sbjct: 1 MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWAS 60
Query: 61 VSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMS 120
VSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMS
Sbjct: 61 VSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMS 120
Query: 121 IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN 180
IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN
Sbjct: 121 IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN 180
Query: 181 EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVII 240
EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVII
Sbjct: 181 EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVII 240
Query: 241 SPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE 300
SPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE
Sbjct: 241 SPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE 300
Query: 301 NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLA 360
NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLA
Sbjct: 301 NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLA 360
Query: 361 FLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 398
FLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK
Sbjct: 361 FLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 398
>gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens]
Length = 398
Score = 825 bits (2130), Expect = 0.0
Identities = 398/398 (100%), Positives = 398/398 (100%)
Query: 1 MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWAS 60
MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWAS
Sbjct: 1 MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWAS 60
Query: 61 VSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMS 120
VSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMS
Sbjct: 61 VSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMS 120
Query: 121 IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN 180
IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN
Sbjct: 121 IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN 180
Query: 181 EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVII 240
EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVII
Sbjct: 181 EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVII 240
Query: 241 SPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE 300
SPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE
Sbjct: 241 SPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE 300
Query: 301 NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLA 360
NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLA
Sbjct: 301 NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLA 360
Query: 361 FLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 398
FLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK
Sbjct: 361 FLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 398
>gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens]
Length = 569
Score = 124 bits (311), Expect = 1e-28
Identities = 79/224 (35%), Positives = 121/224 (54%), Gaps = 10/224 (4%)
Query: 67 LTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVF 126
+TW+K+DS V E+ +R+ LW +PA EDSG Y C RN+SYC ++ I +
Sbjct: 55 ITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFV 114
Query: 127 ENTD--AFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDV-KIQWYKDSLLLDKDNEKF 183
EN + + Q L ++ G LVCP + F + ++ K+QWYKD L DN F
Sbjct: 115 ENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHF 174
Query: 184 LSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPL 243
V+ L+V +VA + G Y C ++ + G+QY ITR IE ++ + T PVI+SP
Sbjct: 175 SGVK--DRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPA 232
Query: 244 -KTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYP 286
+T+ LGS++ + C V TG L+ + +W N + I+ P
Sbjct: 233 NETMEVDLGSQIQLICNV---TG-QLSDIAYWKWNGSVIDEDDP 272
>gi|11225607 interleukin 1 receptor accessory protein-like 2 [Homo
sapiens]
Length = 686
Score = 122 bits (305), Expect = 7e-28
Identities = 96/346 (27%), Positives = 154/346 (44%), Gaps = 36/346 (10%)
Query: 4 LYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSP 63
L ++V V + L+ + + C K L GEPV ++C ++ + S
Sbjct: 7 LALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYIRTNYST 66
Query: 64 R----INLTWHKNDSARTVPGE-EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDK 118
+ L W+KN P E RM ++ ++W A +DSG Y C RN++YC K
Sbjct: 67 AQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMK 126
Query: 119 MSIELRVFENTD--AFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKD---- 172
+S+ L V EN + I Y + ++ + CPD+ +F + + + WYK+
Sbjct: 127 VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPK 186
Query: 173 ---SLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIK 229
S+++ K N LL+ +V ED G Y C L + EG+ + R+ EL++
Sbjct: 187 MWRSIIIQKGNA----------LLIQEVQEEDGGNYTCELKY--EGKL--VRRTTELKVT 232
Query: 230 KKKEETIPVIISPLK----TISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAY 285
+ P + P++ I LG L IPCK F G M++W + IE
Sbjct: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEEL- 291
Query: 286 PGGRVTEGPRQEYSEN-NENYIEVPLIFDPVTREDLHMDFKCVVHN 330
G + EG + E+ E +E+ LIFD V DL ++ C V N
Sbjct: 292 -AGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL-ANYTCHVEN 335
>gi|7657232 interleukin 1 receptor accessory protein-like 1
precursor [Homo sapiens]
Length = 696
Score = 107 bits (266), Expect = 2e-23
Identities = 90/352 (25%), Positives = 155/352 (44%), Gaps = 49/352 (13%)
Query: 7 LVMGVSAFT--LQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASV--- 61
L++ + FT L+ G+A C K+ L GEPV ++C ++ +
Sbjct: 8 LILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLA 67
Query: 62 -SPRINLTWHKNDSARTVPGEEE-------TRMWAQDGALWLLPALQEDSGTYVCTTRNA 113
S ++L W+K+ PG+ E +RM ++ ++W P L +DSG Y C RN+
Sbjct: 68 QSAGLSLMWYKSSG----PGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNS 123
Query: 114 SYCDKMSIELRVFENTD--AFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYK 171
+YC K+SI L V EN + + Y + LS S + C D+ +F + +I WYK
Sbjct: 124 TYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYK 183
Query: 172 D--------SLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRS 223
+ S++ +D LL+ +V +D G Y C L + + + R+
Sbjct: 184 ECRTKTWRPSIVFKRDT-----------LLIREVREDDIGNYTCELKYG----GFVVRRT 228
Query: 224 IELRIKKKKEETIPVIISPLKT----ISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDT 279
EL + + P ++ P+++ LG + C+ F G ++ +++W +
Sbjct: 229 TELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMKGEK 288
Query: 280 HIESAYPGGRVTEGPRQEYSEN-NENYIEVPLIFDPVTREDLHMDFKCVVHN 330
IE RV E + E+ E + + LI D V DL ++ C V N
Sbjct: 289 FIED-LDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLG-NYSCYVEN 338
>gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens]
Length = 575
Score = 103 bits (258), Expect = 2e-22
Identities = 90/303 (29%), Positives = 129/303 (42%), Gaps = 26/303 (8%)
Query: 36 KREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWL 95
K E +P A C P S +++TW+KN S V ++R+ + +
Sbjct: 28 KNEILSASQPFAFNCTFPPI-----TSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILF 82
Query: 96 LPALQEDSGTYVCTTRNASYCDKMSIELRVFEN-----TDAFLPFIS--YPQILTLSTSG 148
LP DSG Y C + C ++ + L VFE + LP +S Y QIL L
Sbjct: 83 LPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDD 142
Query: 149 VLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCV 208
L C F + I+WYKD + E+F + T LLV +V+ ED G Y C
Sbjct: 143 SLTCH--LHFPKSCVLGPIKWYKDCNEIK--GERFTVLE--TRLLVSNVSAEDRGNYACQ 196
Query: 209 LTFAHEGQQYNITRSIELRIKKKKEE--TIPVIISPLK-TISASLGSRLTIPCKVFLGTG 265
H G+QY + I + I ++ ++P II P +I LG+ L + C V T
Sbjct: 197 AILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNV---TD 253
Query: 266 TPLTTML-WWTANDTHIESAYPGG-RVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMD 323
T T L W N+T ++ Y R+ EG S N V + F V ED +
Sbjct: 254 TKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLP 313
Query: 324 FKC 326
F C
Sbjct: 314 FMC 316
>gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [Homo
sapiens]
Length = 556
Score = 95.1 bits (235), Expect = 1e-19
Identities = 82/339 (24%), Positives = 149/339 (43%), Gaps = 28/339 (8%)
Query: 36 KREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWL 95
K+ + LE E + +RCP+ P + W+ + + +++P +E R++A L
Sbjct: 22 KQSWGLENEALIVRCPR-------QGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKF 74
Query: 96 LPALQEDSGTYVCTTRNASYCDKMSIELRVF-ENTDAFLP-FISYPQILTLSTSGVLVCP 153
LPA DSG Y C R+ ++ + ++ + +D +P ++ Y + + + CP
Sbjct: 75 LPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCP 134
Query: 154 --DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTF 211
DL +T ++W+K+ L + + L++ +V EDAG Y C
Sbjct: 135 TIDLYNWT-----APLEWFKNCQALQGSRYR----AHKSFLVIDNVMTEDAGDYTCKFIH 185
Query: 212 AHEGQQYNITRSIELRIKKKKEETI-PVIISPLKT--ISASLGSRLTIPCKVFLGTGTPL 268
G Y++T + +K ++ ++ PVI +P + +G + C G GT
Sbjct: 186 NENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQF 245
Query: 269 TTMLWWTANDTHI-ESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCV 327
+ W N T I + P + EG Q +S N +++ L V EDL + + C+
Sbjct: 246 LAAVLWQLNGTKITDFGEPRIQQEEGQNQSFS-NGLACLDMVLRIADVKEEDLLLQYDCL 304
Query: 328 VHNT--LSFQTLRTTVKEASSTFSWGIVLAPLSLAFLVL 364
N L T+R + K S ++A S+ FL+L
Sbjct: 305 ALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSV-FLML 342
>gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [Homo
sapiens]
Length = 328
Score = 94.4 bits (233), Expect = 2e-19
Identities = 77/320 (24%), Positives = 140/320 (43%), Gaps = 27/320 (8%)
Query: 36 KREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWL 95
K+ + LE E + +RCP+ P + W+ + + +++P +E R++A L
Sbjct: 22 KQSWGLENEALIVRCPR-------QGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKF 74
Query: 96 LPALQEDSGTYVCTTRNASYCDKMSIELRVF-ENTDAFLP-FISYPQILTLSTSGVLVCP 153
LPA DSG Y C R+ ++ + ++ + +D +P ++ Y + + + CP
Sbjct: 75 LPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCP 134
Query: 154 --DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTF 211
DL +T ++W+K+ L + + L++ +V EDAG Y C
Sbjct: 135 TIDLYNWT-----APLEWFKNCQALQGSRYR----AHKSFLVIDNVMTEDAGDYTCKFIH 185
Query: 212 AHEGQQYNITRSIELRIKKKKEETI-PVIISPLKT--ISASLGSRLTIPCKVFLGTGTPL 268
G Y++T + +K ++ ++ PVI +P + +G + C G GT
Sbjct: 186 NENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQF 245
Query: 269 TTMLWWTANDTHI-ESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCV 327
+ W N T I + P + EG Q +S N +++ L V EDL + + C+
Sbjct: 246 LAAVLWQLNGTKITDFGEPRIQQEEGQNQSFS-NGLACLDMVLRIADVKEEDLLLQYDCL 304
Query: 328 VHNT--LSFQTLRTTVKEAS 345
N L T+R + K S
Sbjct: 305 ALNLHGLRRHTVRLSRKNPS 324
>gi|4504661 interleukin 1 receptor accessory protein isoform 1 [Homo
sapiens]
Length = 570
Score = 91.7 bits (226), Expect = 1e-18
Identities = 73/318 (22%), Positives = 127/318 (39%), Gaps = 20/318 (6%)
Query: 24 AARSCRFRGRHYKREFRL-EGEPVALRCPQVPYWLWASVSPR----INLTWHKNDSARTV 78
A+ C G R+ ++ E EP ++CP ++L + S + L W+ R +
Sbjct: 20 ASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDL 79
Query: 79 PGE-----EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFL 133
E R+ + LW P L D+G Y C RN +YC K++ L V + F
Sbjct: 80 EEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFN 139
Query: 134 PFISYPQILTLSTSGV--LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTH 191
+ P G+ + CP++ + I WY + N +
Sbjct: 140 SPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSF 199
Query: 192 LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVIISPLKTI--SA 248
L+ + + G Y CV+T+ G+ +++TR++ +++ + + PVI SP +
Sbjct: 200 LI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEK 256
Query: 249 SLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEV 308
G L IPC V+ +WWT + + + E +E +E ++
Sbjct: 257 EPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTE-DETRTQI 315
Query: 309 PLIFDPVTREDLHMDFKC 326
L VT EDL + C
Sbjct: 316 -LSIKKVTSEDLKRSYVC 332
>gi|19882209 interleukin 1 receptor accessory protein isoform 2
[Homo sapiens]
Length = 356
Score = 91.7 bits (226), Expect = 1e-18
Identities = 73/318 (22%), Positives = 127/318 (39%), Gaps = 20/318 (6%)
Query: 24 AARSCRFRGRHYKREFRL-EGEPVALRCPQVPYWLWASVSPR----INLTWHKNDSARTV 78
A+ C G R+ ++ E EP ++CP ++L + S + L W+ R +
Sbjct: 20 ASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDL 79
Query: 79 PGE-----EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFL 133
E R+ + LW P L D+G Y C RN +YC K++ L V + F
Sbjct: 80 EEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFN 139
Query: 134 PFISYPQILTLSTSGV--LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTH 191
+ P G+ + CP++ + I WY + N +
Sbjct: 140 SPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSF 199
Query: 192 LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVIISPLKTI--SA 248
L+ + + G Y CV+T+ G+ +++TR++ +++ + + PVI SP +
Sbjct: 200 LI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEK 256
Query: 249 SLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEV 308
G L IPC V+ +WWT + + + E +E +E ++
Sbjct: 257 EPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTE-DETRTQI 315
Query: 309 PLIFDPVTREDLHMDFKC 326
L VT EDL + C
Sbjct: 316 -LSIKKVTSEDLKRSYVC 332
>gi|4504657 interleukin 18 receptor accessory protein precursor
[Homo sapiens]
Length = 599
Score = 78.2 bits (191), Expect = 1e-14
Identities = 70/270 (25%), Positives = 113/270 (41%), Gaps = 21/270 (7%)
Query: 102 DSGTYVCTTR------NASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDL 155
+SG+Y+C + + + C KM +E++ N S+ Q L L ++G + CP L
Sbjct: 120 NSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYS-ASHKQDLLLGSTGSISCPSL 178
Query: 156 SEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEG 215
S D + WYK N K LSV + ++V +V G Y C T +
Sbjct: 179 S-CQSDAQSPAVTWYK--------NGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTV 229
Query: 216 QQYNITRSIELRIKKKKEETIPVIISPLK-TISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
+ + +++R + P I+ P++ T+ LG LTI CK G ++ W
Sbjct: 230 SSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKW 289
Query: 275 TANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSF 334
D+ +E V E + S + IE +I + VT+ DL F C V N++
Sbjct: 290 YIKDSDLEWEVS---VPEA-KSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGN 345
Query: 335 QTLRTTVKEASSTFSWGIVLAPLSLAFLVL 364
T +KE I+L + VL
Sbjct: 346 TTQSVQLKEKRGVVLLYILLGTIGTLVAVL 375
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 57.4 bits (137), Expect = 2e-08
Identities = 58/235 (24%), Positives = 96/235 (40%), Gaps = 38/235 (16%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQED 102
G V++ C Y P+ + W ND + G RM DG L++ A +D
Sbjct: 626 GSEVSIMCSATGY-------PKPKIAWTVNDMF--IVGSHRYRM-TSDGTLFIKNAAPKD 675
Query: 103 SGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDK 162
+G Y C N++ DK + LR +I P+++ + + ++ D++
Sbjct: 676 AGIYGCLASNSAGTDKQNSTLR----------YIEAPKLMVVQSELLVALGDITVMECKT 725
Query: 163 TDV---KIQWYKDSLLLDKDNEKFLSVRGTTHLL-VHDVALEDAGYYRCVLTFAHEGQQY 218
+ + +++W+K L L FL + LL + + DAG Y CV +
Sbjct: 726 SGIPPPQVKWFKGDLELRPST--FLIIDPLLGLLKIQETQDLDAGDYTCVAI----NEAG 779
Query: 219 NITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
T I L + PV I +S +GS +T+PC V G P T+ W
Sbjct: 780 RATGKITLDVGSP-----PVFIQEPADVSMEIGSNVTLPCYV---QGYPEPTIKW 826
Score = 56.2 bits (134), Expect = 5e-08
Identities = 58/241 (24%), Positives = 101/241 (41%), Gaps = 25/241 (10%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
+EG PV L C AS +P+ ++ W K + + + DG+L+++
Sbjct: 993 IEGIPVTLPCK-------ASGNPKPSVIWSKKGELISTSSAKFSA--GADGSLYVVSPGG 1043
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR 160
E+SG YVCT N + K ++L V+ F Q + S VL +++
Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEIS-VLAGEEVTLPCE 1102
Query: 161 DKT--DVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQY 218
K+ I W K++ L+ + + + + + + + D+G Y CV T
Sbjct: 1103 VKSLPPPIITWAKETQLISPFSPRHTFLPSGS-MKITETRTSDSGMYLCVAT----NIAG 1157
Query: 219 NITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTAND 278
N+T++++L + P I K + +G R+ IPC GTPL + W
Sbjct: 1158 NVTQAVKLNV-----HVPPKIQRGPKHLKVQVGQRVDIPCN---AQGTPLPVITWSKGGS 1209
Query: 279 T 279
T
Sbjct: 1210 T 1210
Score = 52.0 bits (123), Expect = 9e-07
Identities = 70/302 (23%), Positives = 117/302 (38%), Gaps = 50/302 (16%)
Query: 34 HYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGAL 93
H K +P+ L C A P ++TWHK+ A E + G+L
Sbjct: 4084 HLKEYVIAVDKPITLSCE-------ADGLPPPDITWHKDGRAIV---ESIRQRVLSSGSL 4133
Query: 94 WLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFI-SYPQILTLSTSGVLVC 152
+ D+G Y C N + S +L V P I S T++ + +
Sbjct: 4134 QIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVP-----PRIRSTEGHYTVNENSQAIL 4188
Query: 153 PDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFA 212
P +++ I W KD++LL K+ + L++ +V LED+G+Y CV A
Sbjct: 4189 PCVADGIPTPA---INWKKDNVLLANLLGKY-TAEPYGELILENVVLEDSGFYTCVANNA 4244
Query: 213 HEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTML 272
+ ++ ++ + +P +S + G +L + CK TG PL L
Sbjct: 4245 AGEDTHTVSLTVHV---------LPTFTELPGDVSLNKGEQLRLSCK---ATGIPL-PKL 4291
Query: 273 WWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTL 332
WT N+ I P S N + L+ + V++ED + C N++
Sbjct: 4292 TWTFNNNII------------PAHFDSVNGHS----ELVIERVSKED-SGTYVCTAENSV 4334
Query: 333 SF 334
F
Sbjct: 4335 GF 4336
Score = 51.6 bits (122), Expect = 1e-06
Identities = 53/219 (24%), Positives = 85/219 (38%), Gaps = 36/219 (16%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P+ ++ W KN V + + G+L ++ +D+ TY CT N + DK +++
Sbjct: 3831 PKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVD 3890
Query: 123 LRV-------FENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSL- 174
L V E TD FL P ++T + SGV I W K+ +
Sbjct: 3891 LTVQVPPSIADEPTD-FLVTKHAPAVITCTASGV-------------PFPSIHWTKNGIR 3936
Query: 175 LLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEE 234
LL + + + G +L L AG Y CV A ++T +
Sbjct: 3937 LLPRGDGYRILSSGAIEILA--TQLNHAGRYTCVARNAAGSAHRHVTLHV---------H 3985
Query: 235 TIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
PVI + L + + +PC+ TGTP + W
Sbjct: 3986 EPPVIQPQPSELHVILNNPILLPCE---ATGTPSPFITW 4021
Score = 48.9 bits (115), Expect = 8e-06
Identities = 74/301 (24%), Positives = 121/301 (40%), Gaps = 50/301 (16%)
Query: 42 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 101
+GE + L C A+ P LTW N++ +P ++ + L + +E
Sbjct: 4273 KGEQLRLSCK-------ATGIPLPKLTWTFNNNI--IPAHFDSVNGHSE--LVIERVSKE 4321
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRD 161
DSGTYVCT N+ K +I + F I L + +L C E D
Sbjct: 4322 DSGTYVCTAENSVGFVK-AIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNC----EVKGD 4376
Query: 162 KTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNIT 221
T IQW + +D + + G L ++ EDAG Y CV T + +
Sbjct: 4377 PTPT-IQWNRKG--VDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVAT----NEAGVVE 4429
Query: 222 RSIELRIKKKKEETIPVI-ISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTH 280
RS+ L + ++ P+I + P++T+ + G ++ + C+ TG P T+ W
Sbjct: 4430 RSMSLTL-----QSPPIITLEPVETV-INAGGKIILNCQ---ATGEPQPTITW------- 4473
Query: 281 IESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTT 340
+ G ++ R NN YI +ED +F+CV N + +R
Sbjct: 4474 ---SRQGHSISWDDRVNVLSNNSLYIA------DAQKEDT-SEFECVARNLMGSVLVRVP 4523
Query: 341 V 341
V
Sbjct: 4524 V 4524
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/230 (23%), Positives = 91/230 (39%), Gaps = 20/230 (8%)
Query: 44 EPVALRCPQVPYWLWASVSPRINLTWHKNDS-ARTVPGEEETRMWAQDGALWLLPALQED 102
+PVAL+C A+ P ++TW K+D T G ++ + L + L ED
Sbjct: 1842 KPVALQCI-------ANGIPNPSITWLKDDQPVNTAQGN--LKIQSSGRVLQIAKTLLED 1892
Query: 103 SGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDK 162
+G Y C NA+ + I+L V E + + +S L C
Sbjct: 1893 AGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECK-----AAGN 1947
Query: 163 TDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQ--YNI 220
I WYKD+ LL RG + + + DAG Y+CV + + Y++
Sbjct: 1948 PVPVITWYKDNRLLSGSTSMTFLNRGQI-IDIESAQISDAGIYKCVAINSAGATELFYSL 2006
Query: 221 TRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTT 270
+ I V+ +P++ + G + P +L G+P+++
Sbjct: 2007 QVHVAPSISGSNNMVAVVVNNPVRLECEARG--IPAPSLTWLKDGSPVSS 2054
Score = 46.6 bits (109), Expect = 4e-05
Identities = 47/184 (25%), Positives = 78/184 (42%), Gaps = 20/184 (10%)
Query: 91 GALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISY-PQILTLSTSGV 149
GAL++L D GTY+C N K+ E V T P I P + +
Sbjct: 850 GALFILNLWASDKGTYICEAEN--QFGKIQSETTV-TVTGLVAPLIGISPSVANVIEGQQ 906
Query: 150 LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVL 209
L P + +W K+S +L ++ +++VR L + V L+D G Y CV
Sbjct: 907 LTLP--CTLLAGNPIPERRWIKNSAMLLQN--PYITVRSDGSLHIERVQLQDGGEYTCVA 962
Query: 210 TFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLT 269
++ N T S+ + + +P I + +S G +T+PCK +G P
Sbjct: 963 --SNVAGTNNKTTSVVVHV-------LPTIQHGQQILSTIEGIPVTLPCK---ASGNPKP 1010
Query: 270 TMLW 273
+++W
Sbjct: 1011 SVIW 1014
Score = 45.4 bits (106), Expect = 9e-05
Identities = 56/231 (24%), Positives = 84/231 (36%), Gaps = 24/231 (10%)
Query: 59 ASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDK 118
A +P +TW K S V GE DG L + A D+G Y C N + D+
Sbjct: 1194 AQGTPLPVITWSKGGSTMLVDGEHHVSN--PDGTLSIDQATPSDAGIYTCVATNIAGTDE 1251
Query: 119 MSIELRVFEN---TDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLL 175
I L V E D P+ + Q + CP + I+W +
Sbjct: 1252 TEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCP-----AKGTPKPTIKWLHNGRE 1306
Query: 176 LDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT--FAHEGQQYNITRSIELRIKKKKE 233
L + T L++ V D G Y CV ++YN+ + IK K++
Sbjct: 1307 LTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQ 1366
Query: 234 ETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESA 284
T +S L + C+V GTP ++W+ N ES+
Sbjct: 1367 VT---------NVSVLLNQLTNLFCEV---EGTPSPIIMWYKDNVQVTESS 1405
Score = 45.1 bits (105), Expect = 1e-04
Identities = 62/282 (21%), Positives = 114/282 (40%), Gaps = 40/282 (14%)
Query: 32 GRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDG 91
GR+ + + + P++L C + +P LTW+K+ T ++ +
Sbjct: 2781 GRNGEAKDVIINNPISLYCE-------TNAAPPPTLTWYKDGHPLT--SSDKVLILPGGR 2831
Query: 92 ALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILT--LSTSGV 149
L + A ED+G Y C N + D + ++RV P+ +T ++ S +
Sbjct: 2832 VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSAL 2891
Query: 150 LVCPDLSEFTRDKTDVKIQWYKDSL-LLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCV 208
+ C + + W KD LL+ D+ KFLS +L + + D G Y CV
Sbjct: 2892 IEC-----LSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQIL--NTQITDIGRYVCV 2944
Query: 209 L--TFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGT 266
T + +N+ + + K E + V+++ + +++ C+V +G
Sbjct: 2945 AENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVN----------NFISLTCEV---SGF 2991
Query: 267 PLTTMLWWTANDTHIE-----SAYPGGRVTEGPRQEYSENNE 303
P L W N+ I+ PGGR + R + S+ E
Sbjct: 2992 P-PPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGE 3032
Score = 42.0 bits (97), Expect = 0.001
Identities = 50/219 (22%), Positives = 90/219 (41%), Gaps = 22/219 (10%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P +L+W+K+ + + ++ + A L + A D+G Y C N + D++ +
Sbjct: 2702 PSASLSWYKD--GQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFD 2759
Query: 123 LRVFENTDAFLPFISYPQILTLSTSG----VLVCPDLSEF--TRDKTDVKIQWYKDSLLL 176
+ + + +F +L +G V++ +S + T + WYKD L
Sbjct: 2760 VNI-QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 177 DKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT--FAHEGQQYNITRSIELRIKKKKEE 234
++K L + G L + +EDAG Y CV + QY++ R + I K
Sbjct: 2819 -TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDV-RVLVPPIIKGANS 2876
Query: 235 TIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
+P ++ L SA I C L +G+P W
Sbjct: 2877 DLPEEVTVLVNKSA------LIEC---LSSGSPAPRNSW 2906
Score = 40.0 bits (92), Expect = 0.004
Identities = 60/266 (22%), Positives = 106/266 (39%), Gaps = 46/266 (17%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
+E V+L C AS P ++TW K+ V R+ + L L+
Sbjct: 2399 VEKNSVSLTCE-------ASGIPLPSITWFKD--GWPVSLSNSVRILSGGRMLRLMQTTM 2449
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVF-------ENTDAFLPFISYPQILTLSTSGVLVCP 153
ED+G Y C RNA+ ++ L V ENT + + Q +TL+
Sbjct: 2450 EDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVK-VKEKQSVTLT-------- 2500
Query: 154 DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT--F 211
E T + +I W+KD L +D + + G L + +V + G Y C+ +
Sbjct: 2501 --CEVTGNPVP-EITWHKDGQPLQEDEAHHI-ISGGRFLQITNVQVPHTGRYTCLASSPA 2556
Query: 212 AHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTM 271
H+ + +++ + I + P + ++ L S ++ C+ + P T+
Sbjct: 2557 GHKSRSFSLNVFVSPTIAGVGSDGNP------EDVTVILNSPTSLVCEAY---SYPPATI 2607
Query: 272 LWWTANDTHIES-----AYPGGRVTE 292
W+ + T +ES PGGR +
Sbjct: 2608 TWF-KDGTPLESNRNIRILPGGRTLQ 2632
Score = 40.0 bits (92), Expect = 0.004
Identities = 35/152 (23%), Positives = 66/152 (43%), Gaps = 16/152 (10%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P +TW K+ + + G ++G L + A D+G Y+C NA+ D+ I+
Sbjct: 3740 PTPRITWRKDGAV--LAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRID 3797
Query: 123 LRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDV---KIQWYKDSLLLDKD 179
L+V +P P I T+ ++ + + T + I W K+ LL+ D
Sbjct: 3798 LQV------HVP----PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVD 3847
Query: 180 -NEKFLSVRGTTHLLVHDVALEDAGYYRCVLT 210
N+ + + L++ +++D Y C +T
Sbjct: 3848 QNQNSYRLLSSGSLVIISPSVDDTATYECTVT 3879
Score = 38.5 bits (88), Expect = 0.011
Identities = 58/241 (24%), Positives = 87/241 (36%), Gaps = 42/241 (17%)
Query: 42 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 101
EG V+L C +V P + +TW+KN R + + A L + A
Sbjct: 3073 EGTSVSLECES------NAVPPPV-ITWYKN--GRMITESTHVEILADGQMLHIKKAEVS 3123
Query: 102 DSGTYVCTTRNASYCDKMSIELRVF-------ENTDAFLPFISYPQILTLSTSGVLVCPD 154
D+G YVC N + D + L V+ + + IS P LT +G+
Sbjct: 3124 DTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGI----- 3178
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVR---GTTHLLVHDVALEDAGYYRCVLTF 211
I W K+ + +N L VR G + L + D+G Y C+ +
Sbjct: 3179 --------PPPTIAWLKNHKRI--ENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASN 3228
Query: 212 AHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTM 271
Q SI++ E IP +S LG + + C G TPL
Sbjct: 3229 MEGKAQKYYFLSIQVPPSVAGAE-IP------SDVSVLLGENVELVCNA-NGIPTPLIQW 3280
Query: 272 L 272
L
Sbjct: 3281 L 3281
Score = 35.8 bits (81), Expect = 0.070
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 32/171 (18%)
Query: 45 PVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSG 104
P+ L C A+ +P +TW K G + G L + A++ED+G
Sbjct: 4004 PILLPCE-------ATGTPSPFITWQKEGINVNTSGRNHAVL--PSGGLQISRAVREDAG 4054
Query: 105 TYVCTTRNASYCDKMSIELRV------FENTDAFLPFISYPQILTLSTSGVLVCPDLSEF 158
TY+C +N + I+L V + ++ + P L+ G L PD
Sbjct: 4055 TYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADG-LPPPD---- 4109
Query: 159 TRDKTDVKIQWYKDS-LLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCV 208
I W+KD +++ ++ LS + L + V DAG+Y C+
Sbjct: 4110 --------ITWHKDGRAIVESIRQRVLS---SGSLQIAFVQPGDAGHYTCM 4149
Score = 35.0 bits (79), Expect = 0.12
Identities = 39/171 (22%), Positives = 67/171 (39%), Gaps = 9/171 (5%)
Query: 90 DGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGV 149
DG+L + +D G Y C N + + + + V LP I + Q + + G+
Sbjct: 942 DGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVH-----VLPTIQHGQQILSTIEGI 996
Query: 150 LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVL 209
V K V W K L+ + KF S L V E++G Y C
Sbjct: 997 PVTLPCKASGNPKPSV--IWSKKGELISTSSAKF-SAGADGSLYVVSPGGEESGEYVCTA 1053
Query: 210 TFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKV 260
T + + ++ +R + ++ P++ IS G +T+PC+V
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVE-ISVLAGEEVTLPCEV 1103
Score = 33.9 bits (76), Expect = 0.27
Identities = 57/255 (22%), Positives = 94/255 (36%), Gaps = 32/255 (12%)
Query: 45 PVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ-EDS 103
PV L C A P +LTW K+ S V G + L + Q D+
Sbjct: 2028 PVRLECE-------ARGIPAPSLTWLKDGSP--VSSFSNGLQVLSGGRILALTSAQISDT 2078
Query: 104 GTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKT 163
G Y C NA+ + I+LRV+ + + Q +++ S + S+ T
Sbjct: 2079 GRYTCVAVNAAGEKQRDIDLRVYVPPN----IMGEEQNVSVLISQAVELLCQSDAIPPPT 2134
Query: 164 DVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT--FAHEGQQYNIT 221
+ W KD L K +S + L + D ++D G Y C T + YN+
Sbjct: 2135 ---LTWLKDGHPLLKKPGLSIS-ENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVN 2190
Query: 222 RSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHI 281
+ I E T +I G+ +++ C+ +G P ++W +
Sbjct: 2191 IWVPPNIGGSDELTQLTVIE---------GNLISLLCE---SSGIPPPNLIWKKKGSPVL 2238
Query: 282 ESAYPGGRVTEGPRQ 296
+ R+ G RQ
Sbjct: 2239 TDSMGRVRILSGGRQ 2253
Score = 33.1 bits (74), Expect = 0.45
Identities = 37/181 (20%), Positives = 70/181 (38%), Gaps = 26/181 (14%)
Query: 59 ASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDK 118
A+ +P LTW K+ V + R+ A L ++ A + D G Y+C + + +
Sbjct: 1665 AAGNPSPILTWLKDGVP--VKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKE 1722
Query: 119 MSIELRVF--------ENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWY 170
+ E+ V + T F+ ++ L +G I W
Sbjct: 1723 IKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTG-------------SPPPTIMWL 1769
Query: 171 KDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVL--TFAHEGQQYNITRSIELRI 228
KD L+D + + F + L++ + + G YRC+ T +++ +T + I
Sbjct: 1770 KDGQLID-ERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTI 1828
Query: 229 K 229
K
Sbjct: 1829 K 1829
Score = 31.2 bits (69), Expect = 1.7
Identities = 45/211 (21%), Positives = 81/211 (38%), Gaps = 14/211 (6%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSI 121
+P ++ W K D G+ + + L L A + D G Y CT NA+ I
Sbjct: 1480 TPFPDIHWFK-DGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 122 ELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNE 181
+L ++ P I + T + + L TR I WYKD + ++
Sbjct: 1539 KLTIY-----IPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQ 1593
Query: 182 KFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIIS 241
+G +L + + D+ Y C + A+ + +++ + E + ++
Sbjct: 1594 ALYIDKG-QYLHIPRAQVSDSATYTCHV--ANVAGTAEKSFHVDVYVPPMIEGNLATPLN 1650
Query: 242 PLKTISASLGSRLTIPCKVFLGTGTPLTTML 272
I+ S LT+ CK G +P+ T L
Sbjct: 1651 KQVVIAHS----LTLECKA-AGNPSPILTWL 1676
Score = 30.4 bits (67), Expect = 2.9
Identities = 43/175 (24%), Positives = 66/175 (37%), Gaps = 26/175 (14%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
+EG ++L C +S P NL W K S R+ + L + A +
Sbjct: 2209 IEGNLISLLCE-------SSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEK 2261
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFI----SYPQ--ILTLSTSGVLVCPD 154
D+ Y C N + K L+V+ P I S+P I+T S L C
Sbjct: 2262 SDAALYSCVASNVAGTAKKEYNLQVY-----IRPTITNSGSHPTEIIVTRGKSISLECE- 2315
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLL-VHDVALEDAGYYRCV 208
+ + W KD L K K + + H+L + ++ + D G Y CV
Sbjct: 2316 ----VQGIPPPTVTWMKDGHPLIK--AKGVEILDEGHILQLKNIHVSDTGRYVCV 2364
Score = 29.6 bits (65), Expect = 5.0
Identities = 62/328 (18%), Positives = 114/328 (34%), Gaps = 44/328 (13%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
L GE V L C A+ P + W K+ E R+ A L + AL
Sbjct: 3259 LLGENVELVCN-------ANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR 160
D+G Y C N + + L V+ +++TL + + ++
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSI----NIECRAT 3367
Query: 161 DKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT--FAHEGQQY 218
+I W K+ L L + L G +V + D Y CV + + + Y
Sbjct: 3368 GTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVR-AQVSDVAVYTCVASNRAGVDNKHY 3426
Query: 219 NITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTAN- 277
N +++ + ++ + I+ GS ++ C + GTP +M W
Sbjct: 3427 N----LQVFAPPNMDNSMGT-----EEITVLKGSSTSMAC---ITDGTPAPSMAWLRDGQ 3474
Query: 278 ----DTHIESAYPG-------------GRVTEGPRQEYSENNENYIEVPLIFDPVTREDL 320
D H+ + G G+ T E E ++++I L + +
Sbjct: 3475 PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEE 3534
Query: 321 HMDFKCVVHNTLSFQTLRTTVKEASSTF 348
H + +V+N L + + + T+
Sbjct: 3535 HEEISVIVNNPLELTCIASGIPAPKMTW 3562
Score = 29.3 bits (64), Expect = 6.5
Identities = 25/107 (23%), Positives = 42/107 (39%), Gaps = 15/107 (14%)
Query: 181 EKFLSVRGTTHLLVHDVALEDAGYYRCV-LTFAHEGQQYNITRSIELRIKKKKEETIPVI 239
+++L + +L + V L D G+Y C+ ++ A G+ E PVI
Sbjct: 473 DQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFF---------DVSEPPPVI 523
Query: 240 ISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYP 286
P ++ + G R + C + LT W ND + A P
Sbjct: 524 QVP-NNVTVTPGERAVLTCLIISAVDYNLT----WQRNDRDVRLAEP 565
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 55.1 bits (131), Expect = 1e-07
Identities = 65/244 (26%), Positives = 102/244 (41%), Gaps = 32/244 (13%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P +TW+K+ A ++ EE + L L A DSG Y C NA+ D+ ++
Sbjct: 1774 PNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1831
Query: 123 LRVFENTDAFLPFISYPQ---ILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDS--LLLD 177
L V AF PQ ++ + VL C T + + WYKD L+L
Sbjct: 1832 LSVLV-PPAFRQAPRGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLA 1885
Query: 178 KDNEKFLSVRGTTHLLVHDVALEDAGYYRC-VLTFAHEG-QQYNITRSIELRIKKKKEET 235
+ + ++RG L + + + D G Y C V A E + + +T + + K E
Sbjct: 1886 QRTQ---ALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTE- 1941
Query: 236 IPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPR 295
T+S GS L + C V +G P T+ W + +ES+ G V+ G R
Sbjct: 1942 ---------TVSQVAGSPLVLTCDV---SGVPAPTVT-WLKDRMPVESSAVHGVVSRGGR 1988
Query: 296 QEYS 299
+ S
Sbjct: 1989 LQLS 1992
Score = 54.3 bits (129), Expect = 2e-07
Identities = 61/255 (23%), Positives = 91/255 (35%), Gaps = 41/255 (16%)
Query: 29 RFRGRHYKREFR-LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMW 87
R R RE LEG+ V L C A P ++ W K+ S R +
Sbjct: 2026 RIRSSGVAREHHVLEGQEVRLDCE-------ADGQPPPDVAWLKDGSPLGQDMGPHLRFY 2078
Query: 88 AQDGALWLLPALQEDSGTYVCTTRNASYCD------KMSIELRVFENTDAFLPFISYPQI 141
G+L L D+G Y C N + D + + + + D +S P
Sbjct: 2079 LDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 2138
Query: 142 LTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALED 201
L +VCP R + + W KD L L L G T L + V L D
Sbjct: 2139 LV-----TMVCP-----VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHT-LRISKVQLAD 2187
Query: 202 AGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLK---TISASLGSRLTIPC 258
AG + CV N T ++ +P ++ P++ + GS + +PC
Sbjct: 2188 AGIFTCVAASPAGVADRNFTLQVQ----------VPPVLEPVEFQNDVVVVRGSLVELPC 2237
Query: 259 KVFLGTGTPLTTMLW 273
+ G PL + W
Sbjct: 2238 E---ARGVPLPLVSW 2249
Score = 50.1 bits (118), Expect = 4e-06
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 42/229 (18%)
Query: 59 ASVSPRINLTWHKND-------SARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTR 111
AS PR +TW K S + +PG G L + A ED+G Y+C +
Sbjct: 2780 ASGIPRPTITWQKEGLNVATGVSTQVLPG----------GQLRIAHASPEDAGNYLCIAK 2829
Query: 112 NA--SYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQW 169
N+ S K + ++V + LP +S T + L C R + I W
Sbjct: 2830 NSAGSAMGKTRLVVQVPPVIENGLPDLS----TTEGSHAFLPCK-----ARGSPEPNITW 2880
Query: 170 YKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIK 229
KD + KF +++ + LLV ++ +DAG Y C E R + L I
Sbjct: 2881 DKDGQPVSGAEGKF-TIQPSGELLVKNLEGQDAGTYTCTA----ENAVGRARRRVHLTIL 2935
Query: 230 KKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTAND 278
+PV + S LG RL + C G+P T + WT ND
Sbjct: 2936 -----VLPVFTTLPGDRSLRLGDRLWLRC---AARGSP-TPRIGWTVND 2975
Score = 48.5 bits (114), Expect = 1e-05
Identities = 54/231 (23%), Positives = 92/231 (39%), Gaps = 34/231 (14%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQED 102
G P+ L C A +P+ N+TWHK+ G+ TR+ A +L D
Sbjct: 2319 GAPMELLCD-------AQGTPQPNITWHKD-------GQALTRLENNSRATRVLRV--RD 2362
Query: 103 SGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDK 162
+G Y C + + + S +RV + P P+ + G LV L +
Sbjct: 2363 AGLYTCLAESPAGAIEKSFRVRVQAPPNIVGP--RGPRFVVGLAPGQLV---LECSVEAE 2417
Query: 163 TDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITR 222
KI W++D ++L +D RG L + ++ D+G Y C T + ++
Sbjct: 2418 PAPKITWHRDGIVLQEDAHTQFPERG-RFLQLQALSTADSGDYSC--TARNAAGSTSVAF 2474
Query: 223 SIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
+E+ T+P I S ++ S+ +PC+ G P + W
Sbjct: 2475 RVEI-------HTVPTIRSGPPAVNVSVNQTALLPCQ---ADGVPAPLVSW 2515
Score = 42.4 bits (98), Expect = 7e-04
Identities = 77/323 (23%), Positives = 110/323 (34%), Gaps = 64/323 (19%)
Query: 37 REFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLL 96
R RL G+ + LRC A SP + W ND T E QDG L
Sbjct: 2947 RSLRL-GDRLWLRCA-------ARGSPTPRIGWTVNDRPVTEGVSE------QDGGSTLQ 2992
Query: 97 PAL--QEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCP- 153
A +EDSGTYVC N RV + +L LV P
Sbjct: 2993 RAAVSREDSGTYVCWAEN-----------RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV 3041
Query: 154 ----DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVL 209
L R I W KD L L + + G+ L +H +DAG Y+C+
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGS--LTIHRTERDDAGRYQCLA 3099
Query: 210 TFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLT 269
+ + + + + + ++ PV + ++ G + + C+ TG P
Sbjct: 3100 E-----NEMGVAKKVVILVL----QSAPVFQVEPQDMTVRSGDDVALRCQ---ATGEPTP 3147
Query: 270 TMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVH 329
T+ W A G + R + ++E D T + CV H
Sbjct: 3148 TIEWLQA----------GQPLRASRRLRTLPDGSLWLENVETGDAGT-------YDCVAH 3190
Query: 330 NTLSFQTLRT-TVKEASSTFSWG 351
N L T R V SWG
Sbjct: 3191 NLLGSATARAFLVVRGEPQGSWG 3213
Score = 42.0 bits (97), Expect = 0.001
Identities = 60/257 (23%), Positives = 91/257 (35%), Gaps = 48/257 (18%)
Query: 59 ASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALW-----------LLPALQ------E 101
A+ P ++ W + V G W G+LW L P LQ
Sbjct: 614 AACDPPVHRGWGAHPKPPLVEG------WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLR 667
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRD 161
D G Y C N + K + L+V + ++ + + + S L C
Sbjct: 668 DEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVN--KAVLENASVTLEC-----LASG 720
Query: 162 KTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNIT 221
+ W+K + +SV G L + L DAG YRCV + N+
Sbjct: 721 VPPPDVSWFKGHQPVSSWMGVTVSVDGRV-LRIEQAQLSDAGSYRCVAS--------NVA 771
Query: 222 RSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFL---GTGTPLTTMLWWTAND 278
S ELR + V + P T+ SL + + V L TG P T++W +
Sbjct: 772 GSTELRY------GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN 825
Query: 279 THIESAYPGGRVTEGPR 295
+ PG +V G R
Sbjct: 826 PVSPAGTPGLQVFPGGR 842
Score = 41.2 bits (95), Expect = 0.002
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 34/192 (17%)
Query: 90 DGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGV 149
+G+L + P L +D+G Y+C N++ D+ +LRV E A P S LT T +
Sbjct: 2534 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE-PPAIAPSPS-NLTLTAHTPAL 2591
Query: 150 LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVAL------EDAG 203
L C + W+KD LD F +G LL + L +D+
Sbjct: 2592 LPCE-----ASGSPKPLVVWWKDGQKLD-----FRLQQGAYRLLPSNALLLTAPGPQDSA 2641
Query: 204 YYRCVLT--FAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVF 261
+ CV++ + Y +T + P I + ++ + + + C
Sbjct: 2642 QFECVVSNEVGEAHRLYQVTVHVP-----------PTIADDQTDFTVTMMAPVVLTCH-- 2688
Query: 262 LGTGTPLTTMLW 273
TG P T+ W
Sbjct: 2689 -STGIPAPTVSW 2699
Score = 36.6 bits (83), Expect = 0.041
Identities = 43/211 (20%), Positives = 83/211 (39%), Gaps = 17/211 (8%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P N+TW K+ + +P + L L A D+G Y C NA + +
Sbjct: 339 PTPNITWFKDGAL--LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR 396
Query: 123 LRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEK 182
L V+ + + + +G V L R + W+ + L + + NE
Sbjct: 397 LDVY--VPPTIEGAGGRPYVVKAVAGRPVA--LECVARGHPSPTLSWHHEGLPVAESNES 452
Query: 183 FLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISP 242
L G+ L + +G Y CV + + + S+E+++ + ++
Sbjct: 453 RLETDGSV-LRLESPGEASSGLYSCVA--SSPAGEAVLQYSVEVQVPPQL-----LVAEG 504
Query: 243 LKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
L ++ +G L +PC+ +G+P+ T+ W
Sbjct: 505 LGQVTTIVGQPLELPCQ---ASGSPVPTIQW 532
Score = 35.4 bits (80), Expect = 0.091
Identities = 58/248 (23%), Positives = 92/248 (37%), Gaps = 45/248 (18%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
L+G+ L C + P+ LTW K+ R + + + L +L A
Sbjct: 1267 LDGQTAHLMCNVTGH-------PQPKLTWFKD--GRPLARGDAHHISPDGVLLQVLQANL 1317
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAF-LPFISYPQIL-------------TLST 146
+G Y C NA V E T F L + P IL T++
Sbjct: 1318 SSAGHYSCIAANA-----------VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 1366
Query: 147 SGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYR 206
L+C L+ I W KD + L + GT L + + EDAG Y
Sbjct: 1367 PISLICEALAF-----PSPNITWMKDGAPFEASRNIQL-LPGTHGLQILNAQKEDAGQYT 1420
Query: 207 CVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGT 266
CV+T +E + +E+ I + P+ +K + + S LT+ C+ +
Sbjct: 1421 CVVT--NELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW---AV 1475
Query: 267 PLTTMLWW 274
P T+ W+
Sbjct: 1476 PPPTIRWY 1483
Score = 34.7 bits (78), Expect = 0.16
Identities = 46/183 (25%), Positives = 74/183 (40%), Gaps = 21/183 (11%)
Query: 91 GALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVL 150
GAL + AL +G Y C+ RN++ + L V + + P S + ++ VL
Sbjct: 2719 GALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV-QASPVVKPLPSV--VRAVAEEEVL 2775
Query: 151 VCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT 210
+ + S R I W K+ L + + G L + + EDAG Y C+
Sbjct: 2776 LPCEASGIPRP----TITWQKEGLNVATGVSTQVLPGG--QLRIAHASPEDAGNYLCIAK 2829
Query: 211 FAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTT 270
+ G TR + + PVI + L +S + GS +PCK G+P
Sbjct: 2830 NS-AGSAMGKTRLV--------VQVPPVIENGLPDLSTTEGSHAFLPCK---ARGSPEPN 2877
Query: 271 MLW 273
+ W
Sbjct: 2878 ITW 2880
Score = 32.0 bits (71), Expect = 1.0
Identities = 56/239 (23%), Positives = 84/239 (35%), Gaps = 25/239 (10%)
Query: 42 EGEPVALRCP--QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL 99
EG P +L C VP+ P+I+ W K+ G + A L+L A
Sbjct: 985 EGHPTSLSCECRGVPF-------PKIS--WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQ 1035
Query: 100 QEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFT 159
GTY C N ++L V P P +++ GV L
Sbjct: 1036 LAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP-REPPTQVSVVQDGVAT---LECNA 1091
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 219
K + W +D + + L +G + L V G Y CV E
Sbjct: 1092 TGKPPPTVTWERDGQPVGAELGLQLQNQGQS-LHVERAQAAHTGRYSCVA----ENLAGR 1146
Query: 220 ITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTAND 278
R EL + E + + PL I+A+L S LT+ C+ G P + W+ +
Sbjct: 1147 AERKFELSVLVPPE--LIGDLDPLTNITAALHSPLTLLCEAM---GIPPPAIRWFRGEE 1200
Score = 31.6 bits (70), Expect = 1.3
Identities = 15/51 (29%), Positives = 26/51 (50%), Gaps = 1/51 (1%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRN 112
+P+ +TW K S+ + G+ + ++G+L+L DSG Y C N
Sbjct: 29 TPKPQVTWRKGPSSEPLHGQPGVAV-LEEGSLFLASVSPADSGDYECQATN 78
Score = 29.3 bits (64), Expect = 6.5
Identities = 42/170 (24%), Positives = 64/170 (37%), Gaps = 21/170 (12%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
L PV L C A+ +P L W K+ + + G +++ L L A
Sbjct: 799 LVNTPVRLTCN-------ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARA 851
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPD---LSE 157
DSG Y C +A D+ + L+V +P P IL + +V + L
Sbjct: 852 SDSGRYSCVAVSAVGEDRQDVVLQV------HMP----PSILGEELNVSVVANESVALEC 901
Query: 158 FTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRC 207
+ + W+KD L+ LS L V + DAG+Y C
Sbjct: 902 QSHAMPPPVLSWWKDGRPLEPRPGVHLSA-DKALLQVDRADVWDAGHYTC 950
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 55.1 bits (131), Expect = 1e-07
Identities = 65/244 (26%), Positives = 102/244 (41%), Gaps = 32/244 (13%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P +TW+K+ A ++ EE + L L A DSG Y C NA+ D+ ++
Sbjct: 2965 PNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 3022
Query: 123 LRVFENTDAFLPFISYPQ---ILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDS--LLLD 177
L V AF PQ ++ + VL C T + + WYKD L+L
Sbjct: 3023 LSVLV-PPAFRQAPRGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLA 3076
Query: 178 KDNEKFLSVRGTTHLLVHDVALEDAGYYRC-VLTFAHEG-QQYNITRSIELRIKKKKEET 235
+ + ++RG L + + + D G Y C V A E + + +T + + K E
Sbjct: 3077 QRTQ---ALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTE- 3132
Query: 236 IPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPR 295
T+S GS L + C V +G P T+ W + +ES+ G V+ G R
Sbjct: 3133 ---------TVSQVAGSPLVLTCDV---SGVPAPTVT-WLKDRMPVESSAVHGVVSRGGR 3179
Query: 296 QEYS 299
+ S
Sbjct: 3180 LQLS 3183
Score = 54.3 bits (129), Expect = 2e-07
Identities = 61/255 (23%), Positives = 91/255 (35%), Gaps = 41/255 (16%)
Query: 29 RFRGRHYKREFR-LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMW 87
R R RE LEG+ V L C A P ++ W K+ S R +
Sbjct: 3217 RIRSSGVAREHHVLEGQEVRLDCE-------ADGQPPPDVAWLKDGSPLGQDMGPHLRFY 3269
Query: 88 AQDGALWLLPALQEDSGTYVCTTRNASYCD------KMSIELRVFENTDAFLPFISYPQI 141
G+L L D+G Y C N + D + + + + D +S P
Sbjct: 3270 LDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 3329
Query: 142 LTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALED 201
L +VCP R + + W KD L L L G T L + V L D
Sbjct: 3330 LV-----TMVCP-----VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHT-LRISKVQLAD 3378
Query: 202 AGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLK---TISASLGSRLTIPC 258
AG + CV N T ++ +P ++ P++ + GS + +PC
Sbjct: 3379 AGIFTCVAASPAGVADRNFTLQVQ----------VPPVLEPVEFQNDVVVVRGSLVELPC 3428
Query: 259 KVFLGTGTPLTTMLW 273
+ G PL + W
Sbjct: 3429 E---ARGVPLPLVSW 3440
Score = 50.1 bits (118), Expect = 4e-06
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 42/229 (18%)
Query: 59 ASVSPRINLTWHKND-------SARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTR 111
AS PR +TW K S + +PG G L + A ED+G Y+C +
Sbjct: 3971 ASGIPRPTITWQKEGLNVATGVSTQVLPG----------GQLRIAHASPEDAGNYLCIAK 4020
Query: 112 NA--SYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQW 169
N+ S K + ++V + LP +S T + L C R + I W
Sbjct: 4021 NSAGSAMGKTRLVVQVPPVIENGLPDLS----TTEGSHAFLPCK-----ARGSPEPNITW 4071
Query: 170 YKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIK 229
KD + KF +++ + LLV ++ +DAG Y C E R + L I
Sbjct: 4072 DKDGQPVSGAEGKF-TIQPSGELLVKNLEGQDAGTYTCTA----ENAVGRARRRVHLTIL 4126
Query: 230 KKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTAND 278
+PV + S LG RL + C G+P T + WT ND
Sbjct: 4127 -----VLPVFTTLPGDRSLRLGDRLWLRC---AARGSP-TPRIGWTVND 4166
Score = 48.5 bits (114), Expect = 1e-05
Identities = 54/231 (23%), Positives = 92/231 (39%), Gaps = 34/231 (14%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQED 102
G P+ L C A +P+ N+TWHK+ G+ TR+ A +L D
Sbjct: 3510 GAPMELLCD-------AQGTPQPNITWHKD-------GQALTRLENNSRATRVLRV--RD 3553
Query: 103 SGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDK 162
+G Y C + + + S +RV + P P+ + G LV L +
Sbjct: 3554 AGLYTCLAESPAGAIEKSFRVRVQAPPNIVGP--RGPRFVVGLAPGQLV---LECSVEAE 3608
Query: 163 TDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITR 222
KI W++D ++L +D RG L + ++ D+G Y C T + ++
Sbjct: 3609 PAPKITWHRDGIVLQEDAHTQFPERG-RFLQLQALSTADSGDYSC--TARNAAGSTSVAF 3665
Query: 223 SIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
+E+ T+P I S ++ S+ +PC+ G P + W
Sbjct: 3666 RVEI-------HTVPTIRSGPPAVNVSVNQTALLPCQ---ADGVPAPLVSW 3706
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/236 (24%), Positives = 89/236 (37%), Gaps = 38/236 (16%)
Query: 43 GEPVALRCP---QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL 99
GE L C + PY NLTW ++ R +P D +L + +
Sbjct: 531 GETAVLSCRVLGEAPY----------NLTWVRD--WRVLPASTGRVAQLADLSLEISGII 578
Query: 100 QEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFT 159
D G Y C NA+ + S+ L V E P +S + GV V S
Sbjct: 579 PTDGGRYQCVASNANGVTRASVWLLVRE-----APQVSIHTSSQHFSQGVEVKVSCS--A 631
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 219
I W ++S L +D+ + +GT L++ VA EDAG Y C T Q
Sbjct: 632 SGYPTPHISWSRESQALQEDSRIHVDAQGT--LIIQGVAPEDAGNYSCQATNEVGTDQET 689
Query: 220 ITRSIELRIKKKKEETIPVIISPLK-TISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
+T T P +S + + ++G + C+ +G P ++W+
Sbjct: 690 VTLYY----------TDPPSVSAVNAVVLVAVGEEAVLVCE---ASGVPPPRVIWY 732
Score = 42.4 bits (98), Expect = 7e-04
Identities = 77/304 (25%), Positives = 108/304 (35%), Gaps = 51/304 (16%)
Query: 59 ASVSPRINLTWHKNDSA----RTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNAS 114
A+ P +TW + D R G G L+ ED YVC RN
Sbjct: 809 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV- 867
Query: 115 YCDKMSIELRVFENTDAFLPFI--SYPQILTLSTSGV-LVCPDLSEFTRDKTDVKIQWYK 171
K+ E R+ A P I S P + L V L C L+ + + W K
Sbjct: 868 -FGKVQAEARLIVTGHA-PPQIASSAPTVRVLEGQPVSLPCIVLA----GRPLPERHWLK 921
Query: 172 DSLLLDKDNEKFLSVRGTTHLLVHDVAL-EDAGYYRCVLTFAHEGQQYNITRSIELRIKK 230
D L + + G+ HL D AL E AG Y CV T Q R +EL ++
Sbjct: 922 DGRPLPPGSRHSIRADGSLHL---DRALQEHAGRYSCVATNTAGSQH----RDVELVVQ- 973
Query: 231 KKEETIPVIISPLKTIS-ASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGR 289
+P I P T + G ++PC + +G P T+ W +
Sbjct: 974 -----VPPRIHPTATHHITNEGVPASLPC---VASGVPAPTITW---------TKETNAL 1016
Query: 290 VTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSF--QTLRTTVKE-ASS 346
+ GP S+ I P D + C NT+ F Q +R +V A S
Sbjct: 1017 TSRGPHYNVSKEGTLLIAQPSAQDAGA-------YVCTATNTVGFSSQEMRLSVNRLALS 1069
Query: 347 TFSW 350
+ W
Sbjct: 1070 KYVW 1073
Score = 42.4 bits (98), Expect = 7e-04
Identities = 77/323 (23%), Positives = 110/323 (34%), Gaps = 64/323 (19%)
Query: 37 REFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLL 96
R RL G+ + LRC A SP + W ND T E QDG L
Sbjct: 4138 RSLRL-GDRLWLRCA-------ARGSPTPRIGWTVNDRPVTEGVSE------QDGGSTLQ 4183
Query: 97 PAL--QEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCP- 153
A +EDSGTYVC N RV + +L LV P
Sbjct: 4184 RAAVSREDSGTYVCWAEN-----------RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV 4232
Query: 154 ----DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVL 209
L R I W KD L L + + G+ L +H +DAG Y+C+
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGS--LTIHRTERDDAGRYQCLA 4290
Query: 210 TFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLT 269
+ + + + + + ++ PV + ++ G + + C+ TG P
Sbjct: 4291 E-----NEMGVAKKVVILVL----QSAPVFQVEPQDMTVRSGDDVALRCQ---ATGEPTP 4338
Query: 270 TMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVH 329
T+ W A G + R + ++E D T + CV H
Sbjct: 4339 TIEWLQA----------GQPLRASRRLRTLPDGSLWLENVETGDAGT-------YDCVAH 4381
Query: 330 NTLSFQTLRT-TVKEASSTFSWG 351
N L T R V SWG
Sbjct: 4382 NLLGSATARAFLVVRGEPQGSWG 4404
Score = 42.0 bits (97), Expect = 0.001
Identities = 60/257 (23%), Positives = 91/257 (35%), Gaps = 48/257 (18%)
Query: 59 ASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALW-----------LLPALQ------E 101
A+ P ++ W + V G W G+LW L P LQ
Sbjct: 1805 AACDPPVHRGWGAHPKPPLVEG------WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLR 1858
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRD 161
D G Y C N + K + L+V + ++ + + + S L C
Sbjct: 1859 DEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVN--KAVLENASVTLEC-----LASG 1911
Query: 162 KTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNIT 221
+ W+K + +SV G L + L DAG YRCV + N+
Sbjct: 1912 VPPPDVSWFKGHQPVSSWMGVTVSVDGRV-LRIEQAQLSDAGSYRCVAS--------NVA 1962
Query: 222 RSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFL---GTGTPLTTMLWWTAND 278
S ELR + V + P T+ SL + + V L TG P T++W +
Sbjct: 1963 GSTELRY------GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN 2016
Query: 279 THIESAYPGGRVTEGPR 295
+ PG +V G R
Sbjct: 2017 PVSPAGTPGLQVFPGGR 2033
Score = 41.2 bits (95), Expect = 0.002
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 34/192 (17%)
Query: 90 DGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGV 149
+G+L + P L +D+G Y+C N++ D+ +LRV E A P S LT T +
Sbjct: 3725 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE-PPAIAPSPS-NLTLTAHTPAL 3782
Query: 150 LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVAL------EDAG 203
L C + W+KD LD F +G LL + L +D+
Sbjct: 3783 LPCE-----ASGSPKPLVVWWKDGQKLD-----FRLQQGAYRLLPSNALLLTAPGPQDSA 3832
Query: 204 YYRCVLT--FAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVF 261
+ CV++ + Y +T + P I + ++ + + + C
Sbjct: 3833 QFECVVSNEVGEAHRLYQVTVHVP-----------PTIADDQTDFTVTMMAPVVLTCH-- 3879
Query: 262 LGTGTPLTTMLW 273
TG P T+ W
Sbjct: 3880 -STGIPAPTVSW 3890
Score = 38.9 bits (89), Expect = 0.008
Identities = 48/177 (27%), Positives = 66/177 (37%), Gaps = 31/177 (17%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
LEG+PV+L C + + P W K D PG + DG+L L ALQ
Sbjct: 897 LEGQPVSLPC------IVLAGRPLPERHWLK-DGRPLPPGSRHSIR--ADGSLHLDRALQ 947
Query: 101 EDSGTYVCTTRNASYCDKMSIEL------RVFENTDAFLPFISYPQILTLSTSGVLVCPD 154
E +G Y C N + +EL R+ + P L SGV
Sbjct: 948 EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGV----- 1002
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKF-LSVRGTTHLLVHDVALEDAGYYRCVLT 210
I W K++ L + +S GT LL+ + +DAG Y C T
Sbjct: 1003 --------PAPTITWTKETNALTSRGPHYNVSKEGT--LLIAQPSAQDAGAYVCTAT 1049
Score = 36.6 bits (83), Expect = 0.041
Identities = 43/211 (20%), Positives = 83/211 (39%), Gaps = 17/211 (8%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P N+TW K+ + +P + L L A D+G Y C NA + +
Sbjct: 1530 PTPNITWFKDGAL--LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR 1587
Query: 123 LRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEK 182
L V+ + + + +G V L R + W+ + L + + NE
Sbjct: 1588 LDVY--VPPTIEGAGGRPYVVKAVAGRPVA--LECVARGHPSPTLSWHHEGLPVAESNES 1643
Query: 183 FLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISP 242
L G+ L + +G Y CV + + + S+E+++ + ++
Sbjct: 1644 RLETDGSV-LRLESPGEASSGLYSCVA--SSPAGEAVLQYSVEVQVPPQL-----LVAEG 1695
Query: 243 LKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
L ++ +G L +PC+ +G+P+ T+ W
Sbjct: 1696 LGQVTTIVGQPLELPCQ---ASGSPVPTIQW 1723
Score = 35.4 bits (80), Expect = 0.091
Identities = 58/248 (23%), Positives = 92/248 (37%), Gaps = 45/248 (18%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
L+G+ L C + P+ LTW K+ R + + + L +L A
Sbjct: 2458 LDGQTAHLMCNVTGH-------PQPKLTWFKD--GRPLARGDAHHISPDGVLLQVLQANL 2508
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAF-LPFISYPQIL-------------TLST 146
+G Y C NA V E T F L + P IL T++
Sbjct: 2509 SSAGHYSCIAANA-----------VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 2557
Query: 147 SGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYR 206
L+C L+ I W KD + L + GT L + + EDAG Y
Sbjct: 2558 PISLICEALAF-----PSPNITWMKDGAPFEASRNIQL-LPGTHGLQILNAQKEDAGQYT 2611
Query: 207 CVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGT 266
CV+T +E + +E+ I + P+ +K + + S LT+ C+ +
Sbjct: 2612 CVVT--NELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW---AV 2666
Query: 267 PLTTMLWW 274
P T+ W+
Sbjct: 2667 PPPTIRWY 2674
Score = 35.0 bits (79), Expect = 0.12
Identities = 25/84 (29%), Positives = 35/84 (41%), Gaps = 9/84 (10%)
Query: 42 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 101
EG P +L C AS P +TW K +A T G +++G L + +
Sbjct: 989 EGVPASLPCV-------ASGVPAPTITWTKETNALTSRGPHYNV--SKEGTLLIAQPSAQ 1039
Query: 102 DSGTYVCTTRNASYCDKMSIELRV 125
D+G YVCT N + L V
Sbjct: 1040 DAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 34.7 bits (78), Expect = 0.16
Identities = 46/183 (25%), Positives = 74/183 (40%), Gaps = 21/183 (11%)
Query: 91 GALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVL 150
GAL + AL +G Y C+ RN++ + L V + + P S + ++ VL
Sbjct: 3910 GALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV-QASPVVKPLPSV--VRAVAEEEVL 3966
Query: 151 VCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT 210
+ + S R I W K+ L + + G L + + EDAG Y C+
Sbjct: 3967 LPCEASGIPRP----TITWQKEGLNVATGVSTQVLPGG--QLRIAHASPEDAGNYLCIAK 4020
Query: 211 FAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTT 270
+ G TR + + PVI + L +S + GS +PCK G+P
Sbjct: 4021 NS-AGSAMGKTRLV--------VQVPPVIENGLPDLSTTEGSHAFLPCK---ARGSPEPN 4068
Query: 271 MLW 273
+ W
Sbjct: 4069 ITW 4071
Score = 32.7 bits (73), Expect = 0.59
Identities = 52/240 (21%), Positives = 79/240 (32%), Gaps = 44/240 (18%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
L GE + L C A +P L+W K+ G + G++
Sbjct: 1132 LVGEALDLNCV-------AEGNPEPQLSWSKDGVVLQGRGPQ--------GSVHFAAIRT 1176
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR 160
D+G Y C N++ D +ELRV E S + L CP R
Sbjct: 1177 SDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCP-----AR 1231
Query: 161 DKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNI 220
++ W K + ++V L + V+ D+G Y C Q N
Sbjct: 1232 GTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYEC--------QATNE 1283
Query: 221 TRSIELRIKKKKEETIPVIISP-------LKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
S R K + V + P +S G LT+ C G P+ ++W
Sbjct: 1284 VGSTSRRAK------LVVYVPPSIREDGRKANVSGMAGQSLTLECD---ANGFPVPEIVW 1334
Score = 32.0 bits (71), Expect = 1.0
Identities = 56/239 (23%), Positives = 84/239 (35%), Gaps = 25/239 (10%)
Query: 42 EGEPVALRCP--QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL 99
EG P +L C VP+ P+I+ W K+ G + A L+L A
Sbjct: 2176 EGHPTSLSCECRGVPF-------PKIS--WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQ 2226
Query: 100 QEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFT 159
GTY C N ++L V P P +++ GV L
Sbjct: 2227 LAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP-REPPTQVSVVQDGVAT---LECNA 2282
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 219
K + W +D + + L +G + L V G Y CV E
Sbjct: 2283 TGKPPPTVTWERDGQPVGAELGLQLQNQGQS-LHVERAQAAHTGRYSCVA----ENLAGR 2337
Query: 220 ITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTAND 278
R EL + E + + PL I+A+L S LT+ C+ G P + W+ +
Sbjct: 2338 AERKFELSVLVPPE--LIGDLDPLTNITAALHSPLTLLCEAM---GIPPPAIRWFRGEE 2391
Score = 30.8 bits (68), Expect = 2.2
Identities = 45/185 (24%), Positives = 70/185 (37%), Gaps = 23/185 (12%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
L PV L C A+ +P L W K+ + + G +++ L L A
Sbjct: 1990 LVNTPVRLTCN-------ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARA 2042
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPD---LSE 157
DSG Y C +A D+ + L+V +P P IL + +V + L
Sbjct: 2043 SDSGRYSCVAVSAVGEDRQDVVLQV------HMP----PSILGEELNVSVVANESVALEC 2092
Query: 158 FTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRC--VLTFAHEG 215
+ + W+KD L+ LS L V + DAG+Y C + H
Sbjct: 2093 QSHAMPPPVLSWWKDGRPLEPRPGVHLSA-DKALLQVDRADVWDAGHYTCEALNQAGHSE 2151
Query: 216 QQYNI 220
+ YN+
Sbjct: 2152 KHYNL 2156
Score = 30.4 bits (67), Expect = 2.9
Identities = 44/202 (21%), Positives = 71/202 (35%), Gaps = 24/202 (11%)
Query: 91 GALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVL 150
G+L L DSG Y CT N + S R P++L + L
Sbjct: 1082 GSLRLAQVQVGDSGHYECTASNPA----GSASHRYVLGVQVPPQVQPGPRVLKVLVGEAL 1137
Query: 151 VCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT 210
DL+ + ++ W KD ++L +G+ H + DAG YRC +
Sbjct: 1138 ---DLNCVAEGNPEPQLSWSKDGVVLQGRGP-----QGSVHFAA--IRTSDAGRYRCEAS 1187
Query: 211 FAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTT 270
+ + +ELR+ + L+ ++ G ++PC GTP
Sbjct: 1188 NSAGVDAW----EVELRVLEPPHWGADETSGLLERVA---GENASLPCP---ARGTPKPQ 1237
Query: 271 MLWWTANDTHIESAYPGGRVTE 292
+ W + PG V E
Sbjct: 1238 VTWRKGPSSEPLHGQPGVAVLE 1259
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 55.1 bits (131), Expect = 1e-07
Identities = 65/244 (26%), Positives = 102/244 (41%), Gaps = 32/244 (13%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P +TW+K+ A ++ EE + L L A DSG Y C NA+ D+ ++
Sbjct: 1683 PNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1740
Query: 123 LRVFENTDAFLPFISYPQ---ILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDS--LLLD 177
L V AF PQ ++ + VL C T + + WYKD L+L
Sbjct: 1741 LSVLV-PPAFRQAPRGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLA 1794
Query: 178 KDNEKFLSVRGTTHLLVHDVALEDAGYYRC-VLTFAHEG-QQYNITRSIELRIKKKKEET 235
+ + ++RG L + + + D G Y C V A E + + +T + + K E
Sbjct: 1795 QRTQ---ALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTE- 1850
Query: 236 IPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPR 295
T+S GS L + C V +G P T+ W + +ES+ G V+ G R
Sbjct: 1851 ---------TVSQVAGSPLVLTCDV---SGVPAPTVT-WLKDRMPVESSAVHGVVSRGGR 1897
Query: 296 QEYS 299
+ S
Sbjct: 1898 LQLS 1901
Score = 54.3 bits (129), Expect = 2e-07
Identities = 61/255 (23%), Positives = 91/255 (35%), Gaps = 41/255 (16%)
Query: 29 RFRGRHYKREFR-LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMW 87
R R RE LEG+ V L C A P ++ W K+ S R +
Sbjct: 1935 RIRSSGVAREHHVLEGQEVRLDCE-------ADGQPPPDVAWLKDGSPLGQDMGPHLRFY 1987
Query: 88 AQDGALWLLPALQEDSGTYVCTTRNASYCD------KMSIELRVFENTDAFLPFISYPQI 141
G+L L D+G Y C N + D + + + + D +S P
Sbjct: 1988 LDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 2047
Query: 142 LTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALED 201
L +VCP R + + W KD L L L G T L + V L D
Sbjct: 2048 LV-----TMVCP-----VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHT-LRISKVQLAD 2096
Query: 202 AGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLK---TISASLGSRLTIPC 258
AG + CV N T ++ +P ++ P++ + GS + +PC
Sbjct: 2097 AGIFTCVAASPAGVADRNFTLQVQ----------VPPVLEPVEFQNDVVVVRGSLVELPC 2146
Query: 259 KVFLGTGTPLTTMLW 273
+ G PL + W
Sbjct: 2147 E---ARGVPLPLVSW 2158
Score = 50.1 bits (118), Expect = 4e-06
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 42/229 (18%)
Query: 59 ASVSPRINLTWHKND-------SARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTR 111
AS PR +TW K S + +PG G L + A ED+G Y+C +
Sbjct: 2689 ASGIPRPTITWQKEGLNVATGVSTQVLPG----------GQLRIAHASPEDAGNYLCIAK 2738
Query: 112 NA--SYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQW 169
N+ S K + ++V + LP +S T + L C R + I W
Sbjct: 2739 NSAGSAMGKTRLVVQVPPVIENGLPDLS----TTEGSHAFLPCK-----ARGSPEPNITW 2789
Query: 170 YKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIK 229
KD + KF +++ + LLV ++ +DAG Y C E R + L I
Sbjct: 2790 DKDGQPVSGAEGKF-TIQPSGELLVKNLEGQDAGTYTCTA----ENAVGRARRRVHLTIL 2844
Query: 230 KKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTAND 278
+PV + S LG RL + C G+P T + WT ND
Sbjct: 2845 -----VLPVFTTLPGDRSLRLGDRLWLRC---AARGSP-TPRIGWTVND 2884
Score = 48.5 bits (114), Expect = 1e-05
Identities = 54/231 (23%), Positives = 92/231 (39%), Gaps = 34/231 (14%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQED 102
G P+ L C A +P+ N+TWHK+ G+ TR+ A +L D
Sbjct: 2228 GAPMELLCD-------AQGTPQPNITWHKD-------GQALTRLENNSRATRVLRV--RD 2271
Query: 103 SGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDK 162
+G Y C + + + S +RV + P P+ + G LV L +
Sbjct: 2272 AGLYTCLAESPAGAIEKSFRVRVQAPPNIVGP--RGPRFVVGLAPGQLV---LECSVEAE 2326
Query: 163 TDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITR 222
KI W++D ++L +D RG L + ++ D+G Y C T + ++
Sbjct: 2327 PAPKITWHRDGIVLQEDAHTQFPERG-RFLQLQALSTADSGDYSC--TARNAAGSTSVAF 2383
Query: 223 SIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
+E+ T+P I S ++ S+ +PC+ G P + W
Sbjct: 2384 RVEI-------HTVPTIRSGPPAVNVSVNQTALLPCQ---ADGVPAPLVSW 2424
Score = 42.0 bits (97), Expect = 0.001
Identities = 60/257 (23%), Positives = 91/257 (35%), Gaps = 48/257 (18%)
Query: 59 ASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALW-----------LLPALQ------E 101
A+ P ++ W + V G W G+LW L P LQ
Sbjct: 523 AACDPPVHRGWGAHPKPPLVEG------WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLR 576
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRD 161
D G Y C N + K + L+V + ++ + + + S L C
Sbjct: 577 DEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVN--KAVLENASVTLEC-----LASG 629
Query: 162 KTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNIT 221
+ W+K + +SV G L + L DAG YRCV + N+
Sbjct: 630 VPPPDVSWFKGHQPVSSWMGVTVSVDGRV-LRIEQAQLSDAGSYRCVAS--------NVA 680
Query: 222 RSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFL---GTGTPLTTMLWWTAND 278
S ELR + V + P T+ SL + + V L TG P T++W +
Sbjct: 681 GSTELRY------GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN 734
Query: 279 THIESAYPGGRVTEGPR 295
+ PG +V G R
Sbjct: 735 PVSPAGTPGLQVFPGGR 751
Score = 41.2 bits (95), Expect = 0.002
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 34/192 (17%)
Query: 90 DGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGV 149
+G+L + P L +D+G Y+C N++ D+ +LRV E A P S LT T +
Sbjct: 2443 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE-PPAIAPSPS-NLTLTAHTPAL 2500
Query: 150 LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVAL------EDAG 203
L C + W+KD LD F +G LL + L +D+
Sbjct: 2501 LPCE-----ASGSPKPLVVWWKDGQKLD-----FRLQQGAYRLLPSNALLLTAPGPQDSA 2550
Query: 204 YYRCVLT--FAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVF 261
+ CV++ + Y +T + P I + ++ + + + C
Sbjct: 2551 QFECVVSNEVGEAHRLYQVTVHVP-----------PTIADDQTDFTVTMMAPVVLTCH-- 2597
Query: 262 LGTGTPLTTMLW 273
TG P T+ W
Sbjct: 2598 -STGIPAPTVSW 2608
Score = 39.3 bits (90), Expect = 0.006
Identities = 76/323 (23%), Positives = 109/323 (33%), Gaps = 64/323 (19%)
Query: 37 REFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLL 96
R RL G+ + LRC A SP + W ND T E QDG L
Sbjct: 2856 RSLRL-GDRLWLRCA-------ARGSPTPRIGWTVNDRPVTEGVSE------QDGGSTLQ 2901
Query: 97 PAL--QEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCP- 153
A +EDSGTYVC N RV + +L LV P
Sbjct: 2902 RAAVSREDSGTYVCWAEN-----------RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV 2950
Query: 154 ----DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVL 209
L R I W KD L L + + G+ L + +DAG Y+C+
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGS--LTIRRTERDDAGRYQCLA 3008
Query: 210 TFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLT 269
+ + + + + + ++ PV + ++ G + + C+ TG P
Sbjct: 3009 E-----NEMGVAKKVVILVL----QSAPVFQVEPQDMTVRSGDDVALRCQ---ATGEPTP 3056
Query: 270 TMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVH 329
T+ W A G + R + ++E D T + CV H
Sbjct: 3057 TIEWLQA----------GQPLRASRRLRTLPDGSLWLENVETGDAGT-------YDCVAH 3099
Query: 330 NTLSFQTLRT-TVKEASSTFSWG 351
N L T R V SWG
Sbjct: 3100 NLLGSATARAFLVVRGEPQGSWG 3122
Score = 36.6 bits (83), Expect = 0.041
Identities = 43/211 (20%), Positives = 83/211 (39%), Gaps = 17/211 (8%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P N+TW K+ + +P + L L A D+G Y C NA + +
Sbjct: 248 PTPNITWFKDGAL--LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR 305
Query: 123 LRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEK 182
L V+ + + + +G V L R + W+ + L + + NE
Sbjct: 306 LDVY--VPPTIEGAGGRPYVVKAVAGRPVA--LECVARGHPSPTLSWHHEGLPVAESNES 361
Query: 183 FLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISP 242
L G+ L + +G Y CV + + + S+E+++ + ++
Sbjct: 362 RLETDGSV-LRLESPGEASSGLYSCVA--SSPAGEAVLQYSVEVQVPPQL-----LVAEG 413
Query: 243 LKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
L ++ +G L +PC+ +G+P+ T+ W
Sbjct: 414 LGQVTTIVGQPLELPCQ---ASGSPVPTIQW 441
Score = 36.6 bits (83), Expect = 0.041
Identities = 58/248 (23%), Positives = 92/248 (37%), Gaps = 45/248 (18%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
L+G+ L C + P+ LTW K+ R + + + L +L A
Sbjct: 1176 LDGQTAHLMCNVTGH-------PQPKLTWFKD--GRPLARGDAHHISPDGVLLQVLQANL 1226
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAF-LPFISYPQIL-------------TLST 146
+G Y C NA V E T F L + P IL T++
Sbjct: 1227 SSAGHYSCIAANA-----------VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 1275
Query: 147 SGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYR 206
L+C L+ I W KD + L + GT L + + EDAG Y
Sbjct: 1276 PISLICEALAF-----PSPNITWMKDGAPFEASRNIQL-LPGTHGLQILNAQKEDAGQYT 1329
Query: 207 CVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGT 266
CV+T +E + +E+ I + P+ +K + + S LT+ C+ +
Sbjct: 1330 CVVT--NELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESW---AV 1384
Query: 267 PLTTMLWW 274
P T+ W+
Sbjct: 1385 PPPTIRWY 1392
Score = 34.7 bits (78), Expect = 0.16
Identities = 46/183 (25%), Positives = 74/183 (40%), Gaps = 21/183 (11%)
Query: 91 GALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVL 150
GAL + AL +G Y C+ RN++ + L V + + P S + ++ VL
Sbjct: 2628 GALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV-QASPVVKPLPSV--VRAVAEEEVL 2684
Query: 151 VCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT 210
+ + S R I W K+ L + + G L + + EDAG Y C+
Sbjct: 2685 LPCEASGIPRP----TITWQKEGLNVATGVSTQVLPGG--QLRIAHASPEDAGNYLCIAK 2738
Query: 211 FAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTT 270
+ G TR + + PVI + L +S + GS +PCK G+P
Sbjct: 2739 NS-AGSAMGKTRLV--------VQVPPVIENGLPDLSTTEGSHAFLPCK---ARGSPEPN 2786
Query: 271 MLW 273
+ W
Sbjct: 2787 ITW 2789
Score = 32.3 bits (72), Expect = 0.77
Identities = 53/238 (22%), Positives = 87/238 (36%), Gaps = 36/238 (15%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
L PV L C A+ +P L W K+ + + G +++ L L A
Sbjct: 708 LVNTPVRLTCN-------ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARA 760
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPD---LSE 157
DSG Y C +A D+ + L+V +P P IL + +V + L
Sbjct: 761 SDSGRYSCVAVSAVGEDRQDVVLQV------HMP----PSILGEELNVSVVANESVALEC 810
Query: 158 FTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRC--VLTFAHEG 215
+ + W+KD L+ LS L V + DAG+Y C + H
Sbjct: 811 QSHAMPPPVLSWWKDGRPLEPRPGVHLSA-DKALLQVDRADVWDAGHYTCEALNQAGHSE 869
Query: 216 QQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
+ YN+ + ++ T+ T+ +RL+ C+ G P + W
Sbjct: 870 KHYNLNVWVAPVFPLRESHTL--------TVREGHPTRLSCECR-----GVPFPKISW 914
Score = 31.2 bits (69), Expect = 1.7
Identities = 56/239 (23%), Positives = 83/239 (34%), Gaps = 25/239 (10%)
Query: 42 EGEPVALRCP--QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL 99
EG P L C VP+ P+I+ W K+ G + A L+L A
Sbjct: 894 EGHPTRLSCECRGVPF-------PKIS--WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQ 944
Query: 100 QEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFT 159
GTY C N ++L V P P +++ GV L
Sbjct: 945 LAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP-REPPTQVSVVQDGVAT---LECNA 1000
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 219
K + W +D + + L +G + L V G Y CV E
Sbjct: 1001 TGKPPPTVTWERDGQPVGAELGLQLQNQGQS-LHVERAQAAHTGRYSCVA----ENLAGR 1055
Query: 220 ITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTAND 278
R EL + E + + PL I+A+L S LT+ C+ G P + W+ +
Sbjct: 1056 AERKFELSVLVPPE--LIGDLDPLTNITAALHSPLTLLCEAM---GIPPPAIRWFRGEE 1109
>gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
Length = 541
Score = 52.4 bits (124), Expect = 7e-07
Identities = 51/230 (22%), Positives = 91/230 (39%), Gaps = 27/230 (11%)
Query: 41 LEGEPVALR-CPQVPYWLWASVSPRINLT---WHKNDSART---VPGEEETRMWAQDGAL 93
+EGEP L+ C S++ I T W+K+ ++ + +R+ D L
Sbjct: 31 VEGEPFYLKHCS-------CSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVL 83
Query: 94 WLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCP 153
P D+G+Y +N Y K + + F +I+ + + C
Sbjct: 84 EFWPVELNDTGSYFFQMKN--YTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCE 141
Query: 154 DLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAH 213
+ Q +S L K+ +K L + + ED GYY CV H
Sbjct: 142 NSY----------YQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHH 191
Query: 214 EGQQYNITRSIELRIKKKKEETIPVIISP-LKTISASLGSRLTIPCKVFL 262
G+ +NIT++ + I + + +PV++ P L ++ LG + + C L
Sbjct: 192 NGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALL 241
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/249 (24%), Positives = 100/249 (40%), Gaps = 32/249 (12%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSART-VPGEEETRMWAQDGALWLLPALQE 101
G+ V L+C + P + W KN T +PG+ + GAL +
Sbjct: 154 GDTVLLKCEVIG-------EPMPTIHWQKNQQDLTPIPGDSRVVV-LPSGALQISRLQPG 205
Query: 102 DSGTYVCTTRN-ASYCDKMSIELRVFENTDAF--LPFISYPQ--ILTLSTSGVLVCPDLS 156
D G Y C+ RN AS E+R+ + L F+ P + VL C
Sbjct: 206 DIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLEC---- 261
Query: 157 EFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQ 216
W + ++ ++K+ S+ G ++LL+ +V +D+G Y CV+T+ +E
Sbjct: 262 -CVSGYPPPSFTWLRGEEVIQLRSKKY-SLLGGSNLLISNVTDDDSGMYTCVVTYKNE-- 317
Query: 217 QYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTA 276
NI+ S EL + P ++ + A + C V +G P+ T+ W
Sbjct: 318 --NISASAELTVL-----VPPWFLNHPSNLYAYESMDIEFECTV---SGKPVPTVNWMKN 367
Query: 277 NDTHIESAY 285
D I S Y
Sbjct: 368 GDVVIPSDY 376
Score = 29.6 bits (65), Expect = 5.0
Identities = 43/215 (20%), Positives = 82/215 (38%), Gaps = 39/215 (18%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
+EG+ L C Y P + TW + + + ++ + + + L +
Sbjct: 252 IEGKDAVLECCVSGY-------PPPSFTWLRGEEVIQLRSKKYSLLGGSN--LLISNVTD 302
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLP--FISYPQILTLSTSGVLVCPDLSEF 158
+DSG Y C + S EL V +P F+++P L S + +
Sbjct: 303 DDSGMYTCVVTYKNENISASAELTVL------VPPWFLNHPSNLYAYESMDI---EFECT 353
Query: 159 TRDKTDVKIQWYKDS-LLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQ 217
K + W K+ +++ D + + G ++L + V D G+Y+CV E +
Sbjct: 354 VSGKPVPTVNWMKNGDVVIPSD---YFQIVGGSNLRILGVVKSDEGFYQCVA----ENEA 406
Query: 218 YNITRSIELRIKK-----------KKEETIPVIIS 241
N S +L + K + +PV++S
Sbjct: 407 GNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVS 441
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 50.4 bits (119), Expect = 3e-06
Identities = 59/235 (25%), Positives = 92/235 (39%), Gaps = 48/235 (20%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLL------ 96
GE +L C A +P +TW +D G T + +
Sbjct: 482 GEQFSLMCA-------AKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTG 534
Query: 97 PALQEDSGTYVCTTRN----ASYCDKMSIE----LRVFENTDAFLPFISYPQILTLSTSG 148
P ++ D G Y CT RN A Y ++++ +R N A TL
Sbjct: 535 PQIR-DGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRD------TLINCR 587
Query: 149 VLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCV 208
V+ P S I+WYKD+LLL ++ + + GT L +++ Y V
Sbjct: 588 VIGYPYYS----------IKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSV 637
Query: 209 LTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLG 263
L Q +I++S+ + +K +P +I P + AS+G L IPC V G
Sbjct: 638 LI----QPQLSISQSVHVAVK------VPPLIQPFEFPPASIGQLLYIPCVVSSG 682
Score = 37.0 bits (84), Expect = 0.031
Identities = 42/176 (23%), Positives = 71/176 (40%), Gaps = 24/176 (13%)
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR 160
EDSGTY+C N + + L V + L P+ L ++ LS
Sbjct: 347 EDSGTYICEVTNTFGSAEATGILMVIDPLHVTLT----PKKLKTGIGSTVI---LSCALT 399
Query: 161 DKTDVKIQWYKDSLLLDKDNEKFLSVRGTTH--LLVHDVALEDAGYYRCVLT-FAHEGQQ 217
+ I+WY+++ L+ D + +S+RG ++ LL+ +G Y+C T A Q
Sbjct: 400 GSPEFTIRWYRNTELVLPD--EAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQD 457
Query: 218 YNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
+ I E+ P I+S + G + ++ C G P T+ W
Sbjct: 458 FAII---------ALEDGTPRIVSSFSEKVVNPGEQFSLMC---AAKGAPPPTVTW 501
Score = 35.4 bits (80), Expect = 0.091
Identities = 51/220 (23%), Positives = 86/220 (39%), Gaps = 24/220 (10%)
Query: 59 ASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDS-GTYVCTTRNASYCD 117
+SV +++ + D+ +P E G L++ +ED+ TY C T++ +
Sbjct: 210 SSVQEYVSVVSWEKDTVSIIP--EHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGE 267
Query: 118 KMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKI---QWYKDSL 174
TD P S P IL S + E + I +W KD
Sbjct: 268 TRQSNGARLSVTD---PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGR 324
Query: 175 LLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEE 234
L D+ + G T + D+ ED+G Y C +T N S E +
Sbjct: 325 PLPADSRWTKRITGLT---ISDLRTEDSGTYICEVT--------NTFGSAEATGILMVID 373
Query: 235 TIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
+ V ++P K + +GS + + C + TG+P T+ W+
Sbjct: 374 PLHVTLTP-KKLKTGIGSTVILSCAL---TGSPEFTIRWY 409
Score = 32.3 bits (72), Expect = 0.77
Identities = 17/48 (35%), Positives = 25/48 (52%), Gaps = 6/48 (12%)
Query: 167 IQWYKDS----LLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT 210
++W KDS + + D + + GT LL+ V ED+GYY C T
Sbjct: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGT--LLLRAVKAEDSGYYTCTAT 1426
Score = 30.8 bits (68), Expect = 2.2
Identities = 19/64 (29%), Positives = 27/64 (42%), Gaps = 1/64 (1%)
Query: 63 PRINLTWHKNDSARTVP-GEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSI 121
P + W K+ +P + R+ +G L L EDSG Y CT N D + +
Sbjct: 1377 PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIV 1436
Query: 122 ELRV 125
L V
Sbjct: 1437 NLLV 1440
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor
[Homo sapiens]
Length = 1338
Score = 49.7 bits (117), Expect = 5e-06
Identities = 58/269 (21%), Positives = 104/269 (38%), Gaps = 30/269 (11%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTW------HKNDSARTVPGEEETRMWAQDGALW 94
L G + L C ++ R+ +TW +K S R + + L
Sbjct: 243 LRGHTLVLNCTAT-----TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
Query: 95 LLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPD 154
+ +D G Y C R+ ++ + +++ AF+ + + + L T
Sbjct: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDK--AFIT-VKHRKQQVLETVAGKRSYR 354
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHE 214
LS + ++ W KD L + + ++L+ RG + L++ DV EDAG Y +L+
Sbjct: 355 LSMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYS-LIIKDVTEEDAGNYTILLSIKQS 412
Query: 215 GQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
N+T ++ + +K + E + S LGSR + C + G P W
Sbjct: 413 NVFKNLTATLIVNVKPQIYE--KAVSSFPDPALYPLGSRQILTCTAY-GIPQPTIKWFWH 469
Query: 275 TANDTHIESAYPGGRVTEGPRQEYSENNE 303
N H E+ R ++ NNE
Sbjct: 470 PCNHNHSEA-----------RCDFCSNNE 487
Score = 37.0 bits (84), Expect = 0.031
Identities = 40/176 (22%), Positives = 71/176 (40%), Gaps = 17/176 (9%)
Query: 42 EGEPVALRCPQVPYWL----WASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLP 97
EGE + L C + W + N T H + S + + +E + L ++
Sbjct: 569 EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN---LTIMN 625
Query: 98 ALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFI---SYPQILTLSTSGVLVCPD 154
+DSGTY C RN Y + ++ + D P++ + +S+S L C
Sbjct: 626 VSLQDSGTYACRARNV-YTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDC-- 682
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLT 210
+ +I W+K++ + ++ L G++ L + V ED G Y C T
Sbjct: 683 ---HANGVPEPQITWFKNNHKIQQEPGIILG-PGSSTLFIERVTEEDEGVYHCKAT 734
Score = 33.9 bits (76), Expect = 0.27
Identities = 20/89 (22%), Positives = 41/89 (46%), Gaps = 8/89 (8%)
Query: 189 TTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISA 248
T +L + +V+L+D+G Y C + G++ + I +R ++ P ++ L +
Sbjct: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR-----DQEAPYLLRNLSDHTV 672
Query: 249 SLGSRLTIPCKVFLGTGTPLTTMLWWTAN 277
++ S T+ C G P + W+ N
Sbjct: 673 AISSSTTLDCH---ANGVPEPQITWFKNN 698
>gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor
[Homo sapiens]
Length = 687
Score = 49.7 bits (117), Expect = 5e-06
Identities = 58/269 (21%), Positives = 104/269 (38%), Gaps = 30/269 (11%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTW------HKNDSARTVPGEEETRMWAQDGALW 94
L G + L C ++ R+ +TW +K S R + + L
Sbjct: 243 LRGHTLVLNCTAT-----TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
Query: 95 LLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPD 154
+ +D G Y C R+ ++ + +++ AF+ + + + L T
Sbjct: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDK--AFIT-VKHRKQQVLETVAGKRSYR 354
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHE 214
LS + ++ W KD L + + ++L+ RG + L++ DV EDAG Y +L+
Sbjct: 355 LSMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYS-LIIKDVTEEDAGNYTILLSIKQS 412
Query: 215 GQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
N+T ++ + +K + E + S LGSR + C + G P W
Sbjct: 413 NVFKNLTATLIVNVKPQIYE--KAVSSFPDPALYPLGSRQILTCTAY-GIPQPTIKWFWH 469
Query: 275 TANDTHIESAYPGGRVTEGPRQEYSENNE 303
N H E+ R ++ NNE
Sbjct: 470 PCNHNHSEA-----------RCDFCSNNE 487
>gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor
[Homo sapiens]
Length = 541
Score = 49.7 bits (117), Expect = 5e-06
Identities = 58/269 (21%), Positives = 104/269 (38%), Gaps = 30/269 (11%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTW------HKNDSARTVPGEEETRMWAQDGALW 94
L G + L C ++ R+ +TW +K S R + + L
Sbjct: 243 LRGHTLVLNCTAT-----TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
Query: 95 LLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPD 154
+ +D G Y C R+ ++ + +++ AF+ + + + L T
Sbjct: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDK--AFIT-VKHRKQQVLETVAGKRSYR 354
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHE 214
LS + ++ W KD L + + ++L+ RG + L++ DV EDAG Y +L+
Sbjct: 355 LSMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYS-LIIKDVTEEDAGNYTILLSIKQS 412
Query: 215 GQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
N+T ++ + +K + E + S LGSR + C + G P W
Sbjct: 413 NVFKNLTATLIVNVKPQIYE--KAVSSFPDPALYPLGSRQILTCTAY-GIPQPTIKWFWH 469
Query: 275 TANDTHIESAYPGGRVTEGPRQEYSENNE 303
N H E+ R ++ NNE
Sbjct: 470 PCNHNHSEA-----------RCDFCSNNE 487
>gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 49.7 bits (117), Expect = 5e-06
Identities = 58/269 (21%), Positives = 104/269 (38%), Gaps = 30/269 (11%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTW------HKNDSARTVPGEEETRMWAQDGALW 94
L G + L C ++ R+ +TW +K S R + + L
Sbjct: 243 LRGHTLVLNCTAT-----TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
Query: 95 LLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPD 154
+ +D G Y C R+ ++ + +++ AF+ + + + L T
Sbjct: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDK--AFIT-VKHRKQQVLETVAGKRSYR 354
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHE 214
LS + ++ W KD L + + ++L+ RG + L++ DV EDAG Y +L+
Sbjct: 355 LSMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYS-LIIKDVTEEDAGNYTILLSIKQS 412
Query: 215 GQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
N+T ++ + +K + E + S LGSR + C + G P W
Sbjct: 413 NVFKNLTATLIVNVKPQIYE--KAVSSFPDPALYPLGSRQILTCTAY-GIPQPTIKWFWH 469
Query: 275 TANDTHIESAYPGGRVTEGPRQEYSENNE 303
N H E+ R ++ NNE
Sbjct: 470 PCNHNHSEA-----------RCDFCSNNE 487
Score = 33.9 bits (76), Expect = 0.27
Identities = 20/89 (22%), Positives = 41/89 (46%), Gaps = 8/89 (8%)
Query: 189 TTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISA 248
T +L + +V+L+D+G Y C + G++ + I +R ++ P ++ L +
Sbjct: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR-----DQEAPYLLRNLSDHTV 672
Query: 249 SLGSRLTIPCKVFLGTGTPLTTMLWWTAN 277
++ S T+ C G P + W+ N
Sbjct: 673 AISSSTTLDCH---ANGVPEPQITWFKNN 698
Score = 28.9 bits (63), Expect = 8.5
Identities = 32/151 (21%), Positives = 61/151 (40%), Gaps = 16/151 (10%)
Query: 42 EGEPVALRCPQVPYWL----WASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLP 97
EGE + L C + W + N T H + S + + +E + L ++
Sbjct: 569 EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN---LTIMN 625
Query: 98 ALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFI---SYPQILTLSTSGVLVCPD 154
+DSGTY C RN Y + ++ + D P++ + +S+S L C
Sbjct: 626 VSLQDSGTYACRARNV-YTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDC-- 682
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKFLS 185
+ +I W+K++ + ++ E + S
Sbjct: 683 ---HANGVPEPQITWFKNNHKIQQEPELYTS 710
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 48.5 bits (114), Expect = 1e-05
Identities = 51/217 (23%), Positives = 91/217 (41%), Gaps = 31/217 (14%)
Query: 65 INLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELR 124
I +TW K++ G + + L +L + D+G Y C N + D S +L
Sbjct: 7241 IKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLG 7300
Query: 125 VFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR------DKTDVKIQWYKDSLLLDK 178
V E P+ + +V D EFTR ++K+ WYKD + +
Sbjct: 7301 VQEP----------PRFIKKLEPSRIVKQD--EFTRYECKIGGSPEIKVLWYKDETEIQE 7348
Query: 179 DNEKFLS-VRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIP 237
++ +S V L +H++++ED+G Y C AH + + S L++K+ P
Sbjct: 7349 SSKFRMSFVDSVAVLEMHNLSVEDSGDYTCE---AHNAAG-SASSSTSLKVKEP-----P 7399
Query: 238 VIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
+ I G+ + + C++ GTP + W+
Sbjct: 7400 IFRKKPHPIETLKGADVHLECEL---QGTPPFHVSWY 7433
Score = 47.8 bits (112), Expect = 2e-05
Identities = 51/204 (25%), Positives = 87/204 (42%), Gaps = 19/204 (9%)
Query: 64 RINLTWHKNDSARTVPGEEETRMWAQDGALWLLP-ALQEDSGTYVCTTRNASYCDKMSIE 122
++ +TW K D + PG++ + A +P A +DSGTYVCT N + S
Sbjct: 3672 KVTVTWSK-DGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSAT 3730
Query: 123 LRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNE- 181
+ V E +F+ + ++ S L C + +++ W+K++ L + N
Sbjct: 3731 VTVRE-PPSFVKKVDPSYLMLPGESARLHCK-----LKGSPVIQVTWFKNNKELSESNTV 3784
Query: 182 KFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIIS 241
+ V L + DV +ED+G Y C + + S E+ IK+ P I
Sbjct: 3785 RMYFVNSEAILDITDVKVEDSGSYSCEAV----NDVGSDSCSTEIVIKEP-----PSFIK 3835
Query: 242 PLKTISASLGSRLTIPCKVFLGTG 265
L+ G+ + C+V GTG
Sbjct: 3836 TLEPADIVRGTNALLQCEV-SGTG 3858
Score = 43.5 bits (101), Expect = 3e-04
Identities = 53/240 (22%), Positives = 94/240 (39%), Gaps = 25/240 (10%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRN----ASYCDK 118
P+ ++W+K + + + + Q+ L L+ A ED+ Y C +N A+
Sbjct: 3266 PQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSAS 3325
Query: 119 MSIELRVFENTD----AFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWY-KDS 173
+S+E+ + D + P I P T+++ G P + TD+K+ WY KD
Sbjct: 3326 LSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQ---PARFQCRVSGTDLKVSWYSKDK 3382
Query: 174 LLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIEL------- 226
+ + T L + + ED G Y V + A S+E
Sbjct: 3383 KIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHE 3442
Query: 227 RIKKKKE---ETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIES 283
RI+++ E + PVI ++ + +LG C++ P W+ A ES
Sbjct: 3443 RIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEI---QSAPNVRFQWFKAGREIYES 3499
Score = 43.1 bits (100), Expect = 4e-04
Identities = 37/147 (25%), Positives = 56/147 (38%), Gaps = 7/147 (4%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSI 121
S + + W K + G A + +L L DSGTY C N + + S
Sbjct: 4232 STPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSA 4291
Query: 122 ELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWY-KDSLLLDKDN 180
L V E F+ + Q+L + L C +KI W+ D + +
Sbjct: 4292 NLFVKEPA-TFVEKLEPSQLLKKGDATQLACK-----VTGTPPIKITWFANDREIKESSK 4345
Query: 181 EKFLSVRGTTHLLVHDVALEDAGYYRC 207
+ V T L + DV +ED+G Y C
Sbjct: 4346 HRMSFVESTAVLRLTDVGIEDSGEYMC 4372
Score = 43.1 bits (100), Expect = 4e-04
Identities = 47/215 (21%), Positives = 89/215 (41%), Gaps = 19/215 (8%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ-EDSGTYVCTTRNASYCDKMS 120
+P I++TW KN P + + A+ +P+ ED+G Y C NAS D S
Sbjct: 7894 TPPISVTWKKN-GINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCS 7952
Query: 121 IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYK-DSLLLDKD 179
++ + E F+ + P +++ S L C ++ + WYK D+ L
Sbjct: 7953 AQILILE-PPYFVKQLE-PVKVSVGDSASLQCQ-----LAGTPEIGVSWYKGDTKLRPTT 8005
Query: 180 NEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVI 239
K L+ + V + D+G Y C E ++ S L ++++K P
Sbjct: 8006 TYKMHFRNNVATLVFNQVDINDSGEYIC----KAENSVGEVSASTFLTVQEQK--LPPSF 8059
Query: 240 ISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
L+ + ++G + C + +G+ ++ W+
Sbjct: 8060 SRQLRDVQETVGLPVVFDCAI---SGSEPISVSWY 8091
Score = 42.7 bits (99), Expect = 6e-04
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 16/151 (10%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGA--LWLLPALQEDSGTYVCTTRNASYCDKM 119
SP I + W +N+ +P ++ RM D + + EDSG ++C +N +
Sbjct: 5450 SPEIRVVWFRNE--HELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSC 5507
Query: 120 SIELRVFENTDAFLPFISYPQIL-TLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDK 178
S ++ V E F S+P I+ TL + V + +LS ++ WYKD L +
Sbjct: 5508 STKVIVKEPP----VFSSFPPIVETLKNAEVSLECELS----GTPPFEVVWYKDKRQL-R 5558
Query: 179 DNEKFLSVRGTTHLLVH--DVALEDAGYYRC 207
++K+ H +H +V D G Y C
Sbjct: 5559 SSKKYKIASKNFHTSIHILNVDTSDIGEYHC 5589
Score = 42.4 bits (98), Expect = 7e-04
Identities = 52/242 (21%), Positives = 95/242 (39%), Gaps = 32/242 (13%)
Query: 65 INLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE--DSGTYVCTTRNASYCDKMSIE 122
I++ W K D + E TR+ D L E +SG Y+C +N + + S
Sbjct: 6580 ISVVWLK-DRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAV 6638
Query: 123 LRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEK 182
L V E I P+ +T++T L ++ +W+KD L D++
Sbjct: 6639 LTVLEPAR----IIEKPEPMTVTTGNPFA---LECVVTGTPELSAKWFKDGRELSADSKH 6691
Query: 183 FLS-VRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIIS 241
++ + L + + D G Y + + ++ + RI P I
Sbjct: 6692 HITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVP------PSFIR 6745
Query: 242 PLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPR--QEYS 299
LK ++A LG+ + + C+V +G+ ++ W+ G + GP+ +S
Sbjct: 6746 KLKDVNAILGASVVLECRV---SGSAPISVGWF----------QDGNEIVSGPKCQSSFS 6792
Query: 300 EN 301
EN
Sbjct: 6793 EN 6794
Score = 39.7 bits (91), Expect = 0.005
Identities = 53/226 (23%), Positives = 91/226 (40%), Gaps = 25/226 (11%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGA--LWLLPALQEDSGTYVCTTRNASYCDKM 119
+P + W K S VPGE + +D L L +SG Y C N +
Sbjct: 6860 TPPFKVKWFKG-SRELVPGES-CNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASC 6917
Query: 120 SIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKD 179
+ L V E F+ ++ T +V L + + W KD L+ +
Sbjct: 6918 TTHLFVKEPAT----FVKRLADFSVETGSPIV---LEATYTGTPPISVSWIKDEYLISQS 6970
Query: 180 NEKFLSV-RGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPV 238
+++ +T L + + +ED Y C++ +E Q +I ++ ++ P
Sbjct: 6971 ERCSITMTEKSTILEILESTIEDYAQYSCLIE--NEAGQ-DICEALVSVLEP------PY 7021
Query: 239 IISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESA 284
I PL+ + A +G T+ CKV GTP + W+ + T + SA
Sbjct: 7022 FIEPLEHVEAVIGEPATLQCKV---DGTPEIRISWYKEH-TKLRSA 7063
Score = 39.7 bits (91), Expect = 0.005
Identities = 38/193 (19%), Positives = 70/193 (36%), Gaps = 20/193 (10%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P + W +N G +T + + L + ED G Y C + ++ IE
Sbjct: 8771 PNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIE 8830
Query: 123 LRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEK 182
+ T +++ S C E + D D + WYK L + +
Sbjct: 8831 AEPIQFTKRIQNI-----VVSEHQSATFEC----EVSFD--DAIVTWYKGPTELTESQKY 8879
Query: 183 FLSVRGTTH-LLVHDVALEDAGYYRCVLTFAHEGQQ------YNITRSIELRIKKK--KE 233
G H + +H+V +D G Y + G+ Y T+ I+L +K +
Sbjct: 8880 NFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELKPPDIPD 8939
Query: 234 ETIPVIISPLKTI 246
+P+ P++ +
Sbjct: 8940 SRVPIPTMPIRAV 8952
Score = 38.9 bits (89), Expect = 0.008
Identities = 48/200 (24%), Positives = 74/200 (37%), Gaps = 31/200 (15%)
Query: 86 MWAQDGA--LWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILT 143
+W D + L L A DSGTY+C N V T F+ P
Sbjct: 4816 VWKDDTSTSLELFAAKATDSGTYICQLSN-----------DVGTATSKATLFVKEPPQFI 4864
Query: 144 LSTSGVLVCPDLSEFTRD-----KTDVKIQWYKDSLLLDKDNEKFLS-VRGTTHLLVHDV 197
S VLV + T + +++ WY D + + +S + G +
Sbjct: 4865 KKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGA 4924
Query: 198 ALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIP 257
+E++G Y C + SIEL++K+ P I LK + S + +
Sbjct: 4925 RVENSGTYVC----EARNDAGTASCSIELKVKEP-----PTFIRELKPVEVVKYSDVELE 4975
Query: 258 CKVFLGTGTPLTTMLWWTAN 277
C+V TGTP + W N
Sbjct: 4976 CEV---TGTPPFEVTWLKNN 4992
Score = 38.9 bits (89), Expect = 0.008
Identities = 50/242 (20%), Positives = 89/242 (36%), Gaps = 27/242 (11%)
Query: 33 RHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGA 92
R K L G V + C SP I+++W + + + +T + A
Sbjct: 7686 RKLKETNGLSGSSVVMECKVYG-------SPPISVSWFHEGNEISSGRKYQTTLTDNTCA 7738
Query: 93 LWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVC 152
L + + DSG Y C N + D+ S L V E F+ P + + T +
Sbjct: 7739 LTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPS----FVQKPDPMDVLTGTNVT- 7793
Query: 153 PDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVR-GTTHLLVHDVALEDAGYYRCVLTF 211
+ + + W+K S L + +S+ L + DV +G Y C++
Sbjct: 7794 --FTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIV-- 7849
Query: 212 AHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTM 271
++E + + T + ++ K + L S G L + TGTP ++
Sbjct: 7850 SNEAGKASCTTHLYIKAPAK-------FVKRLNDYSIEKGKPLILEGTF---TGTPPISV 7899
Query: 272 LW 273
W
Sbjct: 7900 TW 7901
Score = 38.9 bits (89), Expect = 0.008
Identities = 42/202 (20%), Positives = 78/202 (38%), Gaps = 20/202 (9%)
Query: 65 INLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELR 124
I ++W K+ G+ + L +L + DSG Y C N D + +L
Sbjct: 8182 IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLN 8241
Query: 125 VFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRD-----KTDVKIQWYKDSLLLDKD 179
+ E P T S + + + F + + + WYK+++ +
Sbjct: 8242 IKERL--------IPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT 8293
Query: 180 NEKFLSVRGTTHLL-VHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPV 238
+ ++ + T +L V + DAG Y C + +++ T SI ++ KK PV
Sbjct: 8294 SNCEITFKNNTLVLQVRKAGMNDAGLYTCKV--SNDAGSALCTSSIVIKEPKKP----PV 8347
Query: 239 IISPLKTISASLGSRLTIPCKV 260
L ++ S G + + C V
Sbjct: 8348 FDQHLTPVTVSEGEYVQLSCHV 8369
Score = 38.5 bits (88), Expect = 0.011
Identities = 41/175 (23%), Positives = 70/175 (40%), Gaps = 19/175 (10%)
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRD 161
++G Y+C +N + L V E A + + P +T+ + L C
Sbjct: 5677 NAGKYICQIKNDGGMRENMATLMVLE--PAVIVEKAGPMTVTVGETCTLECK-----VAG 5729
Query: 162 KTDVKIQWYKD-SLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNI 220
++ ++WYKD LL KF + L + V +DAG Y TF Q N+
Sbjct: 5730 TPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTY----TFQ---VQNNV 5782
Query: 221 TRSIELRIKKKKEETIPVIIS-PLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
+S + + +P + LK LG+ + CKV G+ ++ W+
Sbjct: 5783 GKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKV---AGSSPISVAWF 5834
Score = 38.5 bits (88), Expect = 0.011
Identities = 48/209 (22%), Positives = 79/209 (37%), Gaps = 29/209 (13%)
Query: 42 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGA--LWLLPAL 99
EGE V L C S I + W K + R + + G L L
Sbjct: 8359 EGEYVQLSCH-------VQGSEPIRIQWLK--AGREIKPSDRCSFSFASGTAVLELRDVA 8409
Query: 100 QEDSGTYVCTTRNASYCDKMSIELRVFEN-----------TDAFLPFISYPQILTL--ST 146
+ DSG YVC N + D ++ + + D L F+S PQ + + T
Sbjct: 8410 KADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKT 8469
Query: 147 SGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGT-THLLVHDVALEDAGYY 205
+ + + + K +W + L++ F+ +G L + D D+G Y
Sbjct: 8470 TATFIAKVGGDPIPNVKWTKGKWRQ----LNQGGRVFIHQKGDEAKLEIRDTTKTDSGLY 8525
Query: 206 RCVLTFAHEGQQYNITRSIELRIKKKKEE 234
RCV H + N+ ++ R K++K E
Sbjct: 8526 RCVAFNEHGEIESNVNLQVDERKKQEKIE 8554
Score = 38.1 bits (87), Expect = 0.014
Identities = 39/158 (24%), Positives = 66/158 (41%), Gaps = 24/158 (15%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSI 121
+P I +TW ND + L L EDSG Y+C +N + D S
Sbjct: 4326 TPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSS 4385
Query: 122 ELRVFENTDAFLPFIS--YPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKD 179
+ V E+ P+ + + I L V++ +++ +I W+KD+ +L +
Sbjct: 4386 IVIVKES-----PYFTKEFKPIEVLKEYDVMLLAEVA----GTPPFEITWFKDNTIL-RS 4435
Query: 180 NEKFLSVRGTTHLLVHDVALE-------DAGYYRCVLT 210
K+ T + H V+L+ DAG Y+C +T
Sbjct: 4436 GRKY-----KTFIQDHLVSLQILKFVAADAGEYQCRVT 4468
Score = 38.1 bits (87), Expect = 0.014
Identities = 40/181 (22%), Positives = 68/181 (37%), Gaps = 23/181 (12%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIE 122
P + W+K D G E + L + A ED+G Y C ++ K+ +
Sbjct: 12489 PGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVH 12548
Query: 123 LRVFENTDAFLPFISYPQILTL--STSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN 180
E FIS PQ L + VC + K +QW +D L+ +
Sbjct: 12549 ELAAE-------FISKPQNLEILEGEKAEFVC------SISKESFPVQWKRDDKTLESGD 12595
Query: 181 EKFLSVRGTTH-LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIEL-------RIKKKK 232
+ + G L+V D L+D G Y ++ A + + + R+K+++
Sbjct: 12596 KYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQ 12655
Query: 233 E 233
E
Sbjct: 12656 E 12656
Score = 38.1 bits (87), Expect = 0.014
Identities = 37/167 (22%), Positives = 69/167 (41%), Gaps = 23/167 (13%)
Query: 166 KIQWYKDSLLLDKD-NEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSI 224
++ W+KD + ++K N + V G+T L V D + G Y + N + S
Sbjct: 27989 RVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTV--------EAKNASGSA 28040
Query: 225 ELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTG-TPLT----------TMLW 273
+ IK K ++T ++ P++ + + G ++T+ L G P+T + W
Sbjct: 28041 KAEIKVKVQDTPGKVVGPIRFTNIT-GEKMTLWWDAPLNDGCAPITHYIIEKRETSRLAW 28099
Query: 274 WTANDTHIESAYPGGRVTEGPRQEYSENNENYIEV--PLIFDPVTRE 318
D +Y ++ G ++ + N V PL DPV +
Sbjct: 28100 ALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQ 28146
Score = 37.4 bits (85), Expect = 0.024
Identities = 43/171 (25%), Positives = 63/171 (36%), Gaps = 17/171 (9%)
Query: 42 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 101
+GE + L C S SP I ++W +NDS + L + A E
Sbjct: 6378 QGESIQLECK-------ISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAE 6430
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQ-ILTLSTSGVLVCPDLSEFTR 160
DSG Y+C N S L V A F P + L S V++ ++S
Sbjct: 6431 DSGDYICEAHNGVGDASCSTALTV----KAPPVFTQKPSPVGALKGSDVILQCEIS---- 6482
Query: 161 DKTDVKIQWYKDSLLLDKDNE-KFLSVRGTTHLLVHDVALEDAGYYRCVLT 210
++ W KD + + K S T L + ++ D G Y C T
Sbjct: 6483 GTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKAT 6533
Score = 37.0 bits (84), Expect = 0.031
Identities = 49/213 (23%), Positives = 84/213 (39%), Gaps = 23/213 (10%)
Query: 65 INLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE--DSGTYVCTTRNASYCDKMSIE 122
I++ W K+D + + E+ + D +L + E DSGTY C+ N + ++ S
Sbjct: 4704 ISIQWFKDD--QEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGH 4761
Query: 123 LRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEK 182
L V E F+ PQ ++ + + L + I+W+KD+ L +
Sbjct: 4762 LTVKEPP----YFVEKPQSQDVNPNTRV---QLKALVGGTAPMTIKWFKDNKELHSGAAR 4814
Query: 183 FLSVRGT-THLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIIS 241
+ T T L + D+G Y C L+ T L +K+ + I
Sbjct: 4815 SVWKDDTSTSLELFAAKATDSGTYICQLS----NDVGTATSKATLFVKEPPQ----FIKK 4866
Query: 242 PLKTISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
P + G T C++ TGTP + W+
Sbjct: 4867 PSPVLVLRNGQSTTFECQI---TGTPKIRVSWY 4896
Score = 36.6 bits (83), Expect = 0.041
Identities = 44/196 (22%), Positives = 81/196 (41%), Gaps = 14/196 (7%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSI 121
+P+I ++W+ + + T + + A E+SGTYVC RN + SI
Sbjct: 4888 TPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSI 4947
Query: 122 ELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNE 181
EL+V E F+ + +++ S +L ++ W K++ + +
Sbjct: 4948 ELKVKE-PPTFIRELKPVEVVKYSD------VELECEVTGTPPFEVTWLKNNREIRSSKK 5000
Query: 182 KFLSVR-GTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELR----IKKKKEETI 236
L+ R +L + D G Y+C++ ++EG + + + L+ KK E T
Sbjct: 5001 YTLTDRVSVFNLHITKCDPSDTGEYQCIV--SNEGGSCSCSTRVALKEPPSFIKKIENTT 5058
Query: 237 PVIISPLKTISASLGS 252
V+ S S GS
Sbjct: 5059 TVLKSSATFQSTVAGS 5074
Score = 35.8 bits (81), Expect = 0.070
Identities = 29/129 (22%), Positives = 52/129 (40%), Gaps = 17/129 (13%)
Query: 169 WYKDSLLLDKDNEKFLSVRGTTH-LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELR 227
W KD + + + + +H LL+ D+ EDAG Y + ++ L
Sbjct: 2388 WMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIP------------ALGLS 2435
Query: 228 IKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPG 287
+ +I+PLK ++ G++ + CKV P T + W ND I+
Sbjct: 2436 TSGRVSVYSVDVITPLKDVNVIEGTKAVLECKV----SVPDVTSVKWYLNDEQIKPDDRV 2491
Query: 288 GRVTEGPRQ 296
+ +G +Q
Sbjct: 2492 QAIVKGTKQ 2500
Score = 34.7 bits (78), Expect = 0.16
Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 8/111 (7%)
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR 160
ED+ Y C N + D S L V E +FL Q + ST + +
Sbjct: 5302 EDTANYTCKVSNVAGDDACSGILTVKE-PPSFLVKPGRQQAIPDSTV------EFKAILK 5354
Query: 161 DKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLL-VHDVALEDAGYYRCVLT 210
KI+W+KD + L + F+ + G+T L ++ V G Y C +T
Sbjct: 5355 GTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVT 5405
Score = 33.9 bits (76), Expect = 0.27
Identities = 55/237 (23%), Positives = 90/237 (37%), Gaps = 37/237 (15%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ-E 101
G V L C S S I++ W + D V G + ++++ L L+
Sbjct: 6755 GASVVLECR-------VSGSAPISVGWFQ-DGNEIVSGPKCQSSFSENVCTLNLSLLEPS 6806
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLS-EFT- 159
D+G Y C N + D+ S L V E P + V V P +S FT
Sbjct: 6807 DTGIYTCVAANVAGSDECSAVLTVQE-----------PPSFEQTPDSVEVLPGMSLTFTS 6855
Query: 160 --RDKTDVKIQWYKDSLLLDKDNEKFLSVRG-TTHLLVHDVALEDAGYYRCVLTFAHEGQ 216
R K++W+K S L +S+ T L + +V ++G Y C++T
Sbjct: 6856 VIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVT----ND 6911
Query: 217 QYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 273
+ + + L +K+ + L S GS + + TGTP ++ W
Sbjct: 6912 AGSASCTTHLFVKEP-----ATFVKRLADFSVETGSPIVLEATY---TGTPPISVSW 6960
Score = 33.1 bits (74), Expect = 0.45
Identities = 21/75 (28%), Positives = 35/75 (46%), Gaps = 4/75 (5%)
Query: 169 WYKD-SLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYN---ITRSI 224
W KD S + + +F++ L + DV L DAG Y CVL ++ + + +
Sbjct: 11151 WMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEEL 11210
Query: 225 ELRIKKKKEETIPVI 239
+R K EE + V+
Sbjct: 11211 PVRFVKTLEEEVTVV 11225
Score = 32.7 bits (73), Expect = 0.59
Identities = 31/151 (20%), Positives = 60/151 (39%), Gaps = 6/151 (3%)
Query: 57 LWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYC 116
L A+++ ++ W N T E + D L + A D G C ++
Sbjct: 33058 LKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGI 33117
Query: 117 DKMSIELRVFENTDAFLPFISYPQILTLST-SGVLVCPDLSEFTRDKTDVKIQWYKDSLL 175
K +L + + FIS P+ ++ VL ++S + +I+W+K++L
Sbjct: 33118 VKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEIS----GEPSPEIEWFKNNLP 33173
Query: 176 LD-KDNEKFLSVRGTTHLLVHDVALEDAGYY 205
+ N R L + + ++ D+G Y
Sbjct: 33174 ISISSNVSISRSRNVYSLEIRNASVSDSGKY 33204
Score = 32.3 bits (72), Expect = 0.77
Identities = 16/46 (34%), Positives = 27/46 (58%), Gaps = 1/46 (2%)
Query: 164 DVKIQWYKDSLLLDKDNEKFLSVRGTTHLL-VHDVALEDAGYYRCV 208
++K+ WYK + L+ ++ +S+ G H L V + L+D G YR V
Sbjct: 8685 EIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLV 8730
Score = 31.6 bits (70), Expect = 1.3
Identities = 42/227 (18%), Positives = 79/227 (34%), Gaps = 24/227 (10%)
Query: 62 SPRINLTWHKNDSARTVPGEEETRMWAQDGA--LWLLPALQEDSGTYVCTTRNASYCDKM 119
+P +TW KN+ R + ++ + + L + D+G Y C N
Sbjct: 4981 TPPFEVTWLKNN--REIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSC 5038
Query: 120 SIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKD 179
S + + E + +L S + + I W KD +LD+D
Sbjct: 5039 STRVALKEPPSFIKKIENTTTVLKSSAT-------FQSTVAGSPPISITWLKDDQILDED 5091
Query: 180 NEKFLS-VRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPV 238
+ ++S V L + V +G Y C + + R + ++ +
Sbjct: 5092 DNVYISFVDSVATLQIRSVDNGHSGRYTC-----QAKNESGVERCYAFLLVQEPAQ---- 5142
Query: 239 IISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAY 285
I+ K++ + +T+ C V GTP + W + S Y
Sbjct: 5143 IVEKAKSVDVTEKDPMTLECVV---AGTPELKVKWLKDGKQIVPSRY 5186
Score = 31.6 bits (70), Expect = 1.3
Identities = 52/247 (21%), Positives = 79/247 (31%), Gaps = 25/247 (10%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQED 102
GEP L+C +P I ++W+K + + + +L + D
Sbjct: 7034 GEPATLQCK-------VDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSD 7086
Query: 103 SGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDK 162
G Y C N+ S L + PF + T G V +
Sbjct: 7087 VGEYSCKADNSVGAVASSAVLVI--KARKLPPFFARKLKDVHETLGFPVAFECR--INGS 7142
Query: 163 TDVKIQWYKDSLLLDKD-NEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNIT 221
+++ WYKD +LL D N + V L + G Y C T
Sbjct: 7143 EPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNC------SASNPLGT 7196
Query: 222 RSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHI 281
S ++ + E P ++ +LG T C V TGT + W N
Sbjct: 7197 ASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHV---TGTAPIKITWAKDN---- 7249
Query: 282 ESAYPGG 288
PGG
Sbjct: 7250 REIRPGG 7256
Score = 31.2 bits (69), Expect = 1.7
Identities = 39/169 (23%), Positives = 64/169 (37%), Gaps = 24/169 (14%)
Query: 93 LWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVC 152
L L AL+ D G Y C K+ IE R + P S + + T
Sbjct: 12074 LILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIK---LVRPLHS---VEVMETETARFE 12127
Query: 153 PDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLV-HDVALEDAGYYRCVLTF 211
++SE D+ W L + + + G H LV H+ L+ G
Sbjct: 12128 TEISE-----DDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTG-------- 12174
Query: 212 AHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKV 260
+ Q N+ S LR+K + + ++ PLK ++ + G T C++
Sbjct: 12175 GVDFQAANVKSSAHLRVKPR----VIGLLRPLKDVTVTAGETATFDCEL 12219
Score = 30.8 bits (68), Expect = 2.2
Identities = 52/245 (21%), Positives = 85/245 (34%), Gaps = 26/245 (10%)
Query: 43 GEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQED 102
G PV L C + S I + W+++ +T L +L
Sbjct: 6189 GLPVTLTCR-------LNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSH 6241
Query: 103 SGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDK 162
SG Y C+ N S L E + PF + +G D
Sbjct: 6242 SGQYSCSASNPLGTASSSARLTAREPKKS--PFFDIKPVSIDVIAGESA--DFECHVTGA 6297
Query: 163 TDVKIQWYKDSL-LLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNIT 221
++I W KD+ + N V T HL + V D+G Y C T
Sbjct: 6298 QPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQAT----NDVGKDM 6353
Query: 222 RSIELRIKKKKEETIPVIISPLKTIS-ASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTH 280
S +L +K+ P + L+ A G + + CK+ +G+P + W+ ND+
Sbjct: 6354 CSAQLSVKEP-----PKFVKKLEASKVAKQGESIQLECKI---SGSPEIKVSWF-RNDSE 6404
Query: 281 IESAY 285
+ ++
Sbjct: 6405 LHESW 6409
Score = 30.4 bits (67), Expect = 2.9
Identities = 45/192 (23%), Positives = 72/192 (37%), Gaps = 14/192 (7%)
Query: 53 VPYWLWASVSPRINLTWHKNDSARTVPGEEETRM-WAQDGALWLLP---ALQEDSGTYVC 108
V + + +V P ++TW+K+ + PG+ + + + D L+ L +D Y
Sbjct: 31707 VRFGVTITVHPEPHVTWYKSGQ-KIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTV 31765
Query: 109 TTRNASYCDKMSIELRVFEN---TDAFL-PFISYPQILTLSTSGVLVCPDLSEFTRDKTD 164
RN D +L V + TD+ L P G VC ++
Sbjct: 31766 VARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPT 31825
Query: 165 VKIQWYKDSLLLDKDNEKFLSVRGTTHLLVH--DVALEDAGYYRCVLTFAHEGQQYNITR 222
+K W KD L + G + +H D ED GYYR T
Sbjct: 31826 LK--WEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHL 31883
Query: 223 SIELRIKKKKEE 234
+E R++ KK+E
Sbjct: 31884 QVE-RLRYKKQE 31894
Score = 30.0 bits (66), Expect = 3.8
Identities = 15/55 (27%), Positives = 27/55 (49%), Gaps = 3/55 (5%)
Query: 157 EFTRDKTDVKIQWYKDSLLLD---KDNEKFLSVRGTTHLLVHDVALEDAGYYRCV 208
EF ++ DV WYKD + ++ ++ K++ R + + + DAG Y V
Sbjct: 3167 EFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFV 3221
Score = 30.0 bits (66), Expect = 3.8
Identities = 37/184 (20%), Positives = 66/184 (35%), Gaps = 28/184 (15%)
Query: 101 EDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR 160
ED TY C ++ K S L V FL ++ Q+ + E
Sbjct: 12349 EDIKTYTCDAKDF----KTSCNLNVVPPHVEFLRPLTDLQVREKEMARF-------ECEL 12397
Query: 161 DKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLV-HDVALEDAGYYRCVLTFAHEGQQYN 219
+ + K++W+KD + K + + +G +LV + L+D Y C + A
Sbjct: 12398 SRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLT 12457
Query: 220 ITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDT 279
+ E V L I S + + C+V P ++W+ ++
Sbjct: 12458 VL------------EEEAVFTKNLANIEVSETDTIKLVCEV----SKPGAEVIWYKGDEE 12501
Query: 280 HIES 283
IE+
Sbjct: 12502 IIET 12505
Score = 28.9 bits (63), Expect = 8.5
Identities = 19/72 (26%), Positives = 29/72 (40%), Gaps = 7/72 (9%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
+EGE V L C Y P +TW++ D + + + L + A
Sbjct: 955 IEGESVTLECHISGY-------PSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFA 1007
Query: 101 EDSGTYVCTTRN 112
EDSG + C+ N
Sbjct: 1008 EDSGRFTCSAVN 1019
Score = 28.9 bits (63), Expect = 8.5
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 1/46 (2%)
Query: 165 VKIQWYKDSL-LLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVL 209
VK++WYKD + + + D + S R L + + DA Y CVL
Sbjct: 2203 VKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVL 2248
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/246 (24%), Positives = 94/246 (38%), Gaps = 45/246 (18%)
Query: 41 LEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQ 100
LEG+PV+L C + + P W K D PG + DG+L L ALQ
Sbjct: 780 LEGQPVSLPC------IVLAGRPLPERHWLK-DGRPLPPGSRHSIR--ADGSLHLDRALQ 830
Query: 101 EDSGTYVCTTRNASYCDKMSIEL------RVFENTDAFLPFISYPQILTLSTSGVLVCPD 154
E +G Y C N + +EL R+ + P L SGV
Sbjct: 831 EHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGV----- 885
Query: 155 LSEFTRDKTDVKIQWYKDSLLLDKDNEKF-LSVRGTTHLLVHDVALEDAGYYRCVLT--- 210
I W K++ L + +S GT LL+ + +DAG Y C T
Sbjct: 886 --------PAPTITWTKETNALTSRGPHYNVSKEGT--LLIAQPSAQDAGAYVCTATNTV 935
Query: 211 -FAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLT 269
F+ + + ++ + + + +P+ ++A G +T+ C+ G+ PL
Sbjct: 936 GFSSQEMRLSVNTKPRIHMNGSRNANVPL------QVTAKAGEEVTLDCEA-KGSPPPLV 988
Query: 270 TMLWWT 275
T WT
Sbjct: 989 T---WT 991
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/236 (24%), Positives = 89/236 (37%), Gaps = 38/236 (16%)
Query: 43 GEPVALRCP---QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL 99
GE L C + PY NLTW ++ R +P D +L + +
Sbjct: 414 GETAVLSCRVLGEAPY----------NLTWVRD--WRVLPASTGRVAQLADLSLEISGII 461
Query: 100 QEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFT 159
D G Y C NA+ + S+ L V E P +S + GV V S
Sbjct: 462 PTDGGRYQCVASNANGVTRASVWLLVRE-----APQVSIHTSSQHFSQGVEVKVSCS--A 514
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 219
I W ++S L +D+ + +GT L++ VA EDAG Y C T Q
Sbjct: 515 SGYPTPHISWSRESQALQEDSRIHVDAQGT--LIIQGVAPEDAGNYSCQATNEVGTDQET 572
Query: 220 ITRSIELRIKKKKEETIPVIISPLK-TISASLGSRLTIPCKVFLGTGTPLTTMLWW 274
+T T P +S + + ++G + C+ +G P ++W+
Sbjct: 573 VTLYY----------TDPPSVSAVNAVVLVAVGEEAVLVCE---ASGVPPPRVIWY 615
Score = 40.4 bits (93), Expect = 0.003
Identities = 74/294 (25%), Positives = 104/294 (35%), Gaps = 50/294 (17%)
Query: 59 ASVSPRINLTWHKNDSA----RTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNAS 114
A+ P +TW + D R G G L+ ED YVC RN
Sbjct: 692 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV- 750
Query: 115 YCDKMSIELRVFENTDAFLPFI--SYPQILTLSTSGV-LVCPDLSEFTRDKTDVKIQWYK 171
K+ E R+ A P I S P + L V L C L+ + + W K
Sbjct: 751 -FGKVQAEARLIVTGHA-PPQIASSAPTVRVLEGQPVSLPCIVLA----GRPLPERHWLK 804
Query: 172 DSLLLDKDNEKFLSVRGTTHLLVHDVAL-EDAGYYRCVLTFAHEGQQYNITRSIELRIKK 230
D L + + G+ HL D AL E AG Y CV T Q R +EL ++
Sbjct: 805 DGRPLPPGSRHSIRADGSLHL---DRALQEHAGRYSCVATNTAGSQH----RDVELVVQ- 856
Query: 231 KKEETIPVIISPLKTIS-ASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGR 289
+P I P T + G ++PC + +G P T+ W +
Sbjct: 857 -----VPPRIHPTATHHITNEGVPASLPC---VASGVPAPTITW---------TKETNAL 899
Query: 290 VTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSF--QTLRTTV 341
+ GP S+ I P D + C NT+ F Q +R +V
Sbjct: 900 TSRGPHYNVSKEGTLLIAQPSAQDAGA-------YVCTATNTVGFSSQEMRLSV 946
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 48.1 bits (113), Expect = 1e-05
Identities = 40/164 (24%), Positives = 64/164 (39%), Gaps = 11/164 (6%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWA--QDGALWLLPALQEDSGTYVCTTRNASYCDKMS 120
P + W K D P E RM +D +++ ED G Y CT +N++ +
Sbjct: 630 PAPQIAWQK-DGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 688
Query: 121 IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN 180
L V E P + + +T + VL C K+ W KD L
Sbjct: 689 ATLTVLETPSFLRPLLD--RTVTKGETAVLQC-----IAGGSPPPKLNWTKDDSPLVVTE 741
Query: 181 EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSI 224
F + G L++ D + DAG Y C ++ ++ N+ S+
Sbjct: 742 RHFFAA-GNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 784
Score = 29.3 bits (64), Expect = 6.5
Identities = 27/125 (21%), Positives = 48/125 (38%), Gaps = 20/125 (16%)
Query: 169 WYKDSLLL-DKDNEKFLSVRG--------TTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 219
W KD+ LL D + E + +R TT L + +V G Y+CV++ H G Y+
Sbjct: 534 WKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVIS-NHFGSSYS 592
Query: 220 ITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDT 279
+ + + + +P ++ G+ + C G P + W T
Sbjct: 593 VKAKLTVNM-------LPSFTKTPMDLTIRAGAMARLEC---AAVGHPAPQIAWQKDGGT 642
Query: 280 HIESA 284
+A
Sbjct: 643 DFPAA 647
Score = 29.3 bits (64), Expect = 6.5
Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 9/100 (9%)
Query: 42 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 101
+GE L+C A SP L W K+DS V E A + L ++ +
Sbjct: 710 KGETAVLQCI-------AGGSPPPKLNWTKDDSPLVVT--ERHFFAAGNQLLIIVDSDVS 760
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQI 141
D+G Y C N ++ ++ L V P ++ P +
Sbjct: 761 DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSL 800
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 48.1 bits (113), Expect = 1e-05
Identities = 40/164 (24%), Positives = 64/164 (39%), Gaps = 11/164 (6%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWA--QDGALWLLPALQEDSGTYVCTTRNASYCDKMS 120
P + W K D P E RM +D +++ ED G Y CT +N++ +
Sbjct: 570 PAPQIAWQK-DGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628
Query: 121 IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN 180
L V E P + + +T + VL C K+ W KD L
Sbjct: 629 ATLTVLETPSFLRPLLD--RTVTKGETAVLQC-----IAGGSPPPKLNWTKDDSPLVVTE 681
Query: 181 EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSI 224
F + G L++ D + DAG Y C ++ ++ N+ S+
Sbjct: 682 RHFFAA-GNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724
Score = 29.3 bits (64), Expect = 6.5
Identities = 27/125 (21%), Positives = 48/125 (38%), Gaps = 20/125 (16%)
Query: 169 WYKDSLLL-DKDNEKFLSVRG--------TTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 219
W KD+ LL D + E + +R TT L + +V G Y+CV++ H G Y+
Sbjct: 474 WKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVIS-NHFGSSYS 532
Query: 220 ITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDT 279
+ + + + +P ++ G+ + C G P + W T
Sbjct: 533 VKAKLTVNM-------LPSFTKTPMDLTIRAGAMARLEC---AAVGHPAPQIAWQKDGGT 582
Query: 280 HIESA 284
+A
Sbjct: 583 DFPAA 587
Score = 29.3 bits (64), Expect = 6.5
Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 9/100 (9%)
Query: 42 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 101
+GE L+C A SP L W K+DS V E A + L ++ +
Sbjct: 650 KGETAVLQCI-------AGGSPPPKLNWTKDDSPLVVT--ERHFFAAGNQLLIIVDSDVS 700
Query: 102 DSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQI 141
D+G Y C N ++ ++ L V P ++ P +
Sbjct: 701 DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSL 740
>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
Length = 1863
Score = 47.8 bits (112), Expect = 2e-05
Identities = 47/194 (24%), Positives = 77/194 (39%), Gaps = 20/194 (10%)
Query: 93 LWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLV- 151
L + AL ED GTY C NA S + V E + P + T+ + +
Sbjct: 568 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQ 627
Query: 152 -CPDLSEFTRDKTDVKIQ----------WYKDSLLLDKDNEKFLSVRGTTH-LLVHDVAL 199
DL + + +Q W + + + + RGT H L + +V
Sbjct: 628 GLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFP 687
Query: 200 EDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCK 259
ED G Y C + G+ + L +++ + T P IS ++++ASLG + I C
Sbjct: 688 EDTGTYTCE-AWNSAGE---VRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCA 743
Query: 260 VFLGTGTPLTTMLW 273
+ G P T+ W
Sbjct: 744 I---AGDPFPTVHW 754
Score = 37.0 bits (84), Expect = 0.031
Identities = 59/261 (22%), Positives = 94/261 (36%), Gaps = 35/261 (13%)
Query: 29 RFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWH-KNDSARTVPGEEETRMW 87
+F + +E + E + V RC S P+ + W + R G E
Sbjct: 415 KFESKPQSQEVK-ENQTVKFRCE-------VSGIPKPEVAWFLEGTPVRRQEGSIEVYED 466
Query: 88 AQDGALWLLPALQEDSGTYVCTTRNA----SYCDKMSIE-LRVFENTDAFLPFISYPQIL 142
A L LL A DSGTY CT NA S + +E L V E +F + ++
Sbjct: 467 AGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVI 526
Query: 143 TLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDA 202
VL C R +I W + + + G L + D ED
Sbjct: 527 E-GQDFVLQCS-----VRGTPVPRITWLLNGQPI--QYARSTCEAGVAELHIQDALPEDH 578
Query: 203 GYYRCVLTFAHEGQQYNITRSIELRIKKKKEE----------TIPVIISPLKTISASLGS 252
G Y C+ A + ++ + +K E T P+ + L + GS
Sbjct: 579 GTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGS 638
Query: 253 RLTIPCKVFLGTGTPLTTMLW 273
++T+ +V +G P ++W
Sbjct: 639 QVTMTVQV---SGNPPPEVIW 656
Score = 35.4 bits (80), Expect = 0.091
Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 11/100 (11%)
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLS--VRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQ 217
R + ++ W+++ + L +RGT L++H V ED G Y C T +Q
Sbjct: 57 RGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQ 116
Query: 218 YNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIP 257
+ ++E K+ + + +S +LG R + P
Sbjct: 117 VTVELTVEGSFAKQLGQPV---------VSKTLGDRFSAP 147
Score = 32.0 bits (71), Expect = 1.0
Identities = 39/161 (24%), Positives = 60/161 (37%), Gaps = 6/161 (3%)
Query: 52 QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTR 111
QV + S +P + W N + + +L + ED+GTY C
Sbjct: 639 QVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAW 698
Query: 112 NASYCDKMSIELRVFENTDAFLP-FISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWY 170
N++ + L V E D P FIS P+ +T S ++ +S + W
Sbjct: 699 NSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL---ISCAIAGDPFPTVHWL 755
Query: 171 KDSLLLDKDNEKF--LSVRGTTHLLVHDVALEDAGYYRCVL 209
+D L KD F L L++ V AG Y +L
Sbjct: 756 RDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILL 796
Score = 30.0 bits (66), Expect = 3.8
Identities = 18/64 (28%), Positives = 29/64 (45%), Gaps = 1/64 (1%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL-QEDSGTYVCTTRNASYCDKMSI 121
P +TWH+N T G + ++ A+ +ED G Y C N S ++++
Sbjct: 60 PEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTV 119
Query: 122 ELRV 125
EL V
Sbjct: 120 ELTV 123
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 47.8 bits (112), Expect = 2e-05
Identities = 47/194 (24%), Positives = 77/194 (39%), Gaps = 20/194 (10%)
Query: 93 LWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLV- 151
L + AL ED GTY C NA S + V E + P + T+ + +
Sbjct: 568 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQ 627
Query: 152 -CPDLSEFTRDKTDVKIQ----------WYKDSLLLDKDNEKFLSVRGTTH-LLVHDVAL 199
DL + + +Q W + + + + RGT H L + +V
Sbjct: 628 GLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFP 687
Query: 200 EDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCK 259
ED G Y C + G+ + L +++ + T P IS ++++ASLG + I C
Sbjct: 688 EDTGTYTCE-AWNSAGE---VRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCA 743
Query: 260 VFLGTGTPLTTMLW 273
+ G P T+ W
Sbjct: 744 I---AGDPFPTVHW 754
Score = 37.0 bits (84), Expect = 0.031
Identities = 59/261 (22%), Positives = 94/261 (36%), Gaps = 35/261 (13%)
Query: 29 RFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWH-KNDSARTVPGEEETRMW 87
+F + +E + E + V RC S P+ + W + R G E
Sbjct: 415 KFESKPQSQEVK-ENQTVKFRCE-------VSGIPKPEVAWFLEGTPVRRQEGSIEVYED 466
Query: 88 AQDGALWLLPALQEDSGTYVCTTRNA----SYCDKMSIE-LRVFENTDAFLPFISYPQIL 142
A L LL A DSGTY CT NA S + +E L V E +F + ++
Sbjct: 467 AGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVI 526
Query: 143 TLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDA 202
VL C R +I W + + + G L + D ED
Sbjct: 527 E-GQDFVLQCS-----VRGTPVPRITWLLNGQPI--QYARSTCEAGVAELHIQDALPEDH 578
Query: 203 GYYRCVLTFAHEGQQYNITRSIELRIKKKKEE----------TIPVIISPLKTISASLGS 252
G Y C+ A + ++ + +K E T P+ + L + GS
Sbjct: 579 GTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGS 638
Query: 253 RLTIPCKVFLGTGTPLTTMLW 273
++T+ +V +G P ++W
Sbjct: 639 QVTMTVQV---SGNPPPEVIW 656
Score = 35.4 bits (80), Expect = 0.091
Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 11/100 (11%)
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLS--VRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQ 217
R + ++ W+++ + L +RGT L++H V ED G Y C T +Q
Sbjct: 57 RGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQ 116
Query: 218 YNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIP 257
+ ++E K+ + + +S +LG R + P
Sbjct: 117 VTVELTVEGSFAKQLGQPV---------VSKTLGDRFSAP 147
Score = 32.0 bits (71), Expect = 1.0
Identities = 39/161 (24%), Positives = 60/161 (37%), Gaps = 6/161 (3%)
Query: 52 QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTR 111
QV + S +P + W N + + +L + ED+GTY C
Sbjct: 639 QVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAW 698
Query: 112 NASYCDKMSIELRVFENTDAFLP-FISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWY 170
N++ + L V E D P FIS P+ +T S ++ +S + W
Sbjct: 699 NSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL---ISCAIAGDPFPTVHWL 755
Query: 171 KDSLLLDKDNEKF--LSVRGTTHLLVHDVALEDAGYYRCVL 209
+D L KD F L L++ V AG Y +L
Sbjct: 756 RDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILL 796
Score = 30.0 bits (66), Expect = 3.8
Identities = 18/64 (28%), Positives = 29/64 (45%), Gaps = 1/64 (1%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL-QEDSGTYVCTTRNASYCDKMSI 121
P +TWH+N T G + ++ A+ +ED G Y C N S ++++
Sbjct: 60 PEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTV 119
Query: 122 ELRV 125
EL V
Sbjct: 120 ELTV 123
>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
Length = 1794
Score = 47.8 bits (112), Expect = 2e-05
Identities = 47/194 (24%), Positives = 77/194 (39%), Gaps = 20/194 (10%)
Query: 93 LWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLV- 151
L + AL ED GTY C NA S + V E + P + T+ + +
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQ 558
Query: 152 -CPDLSEFTRDKTDVKIQ----------WYKDSLLLDKDNEKFLSVRGTTH-LLVHDVAL 199
DL + + +Q W + + + + RGT H L + +V
Sbjct: 559 GLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFP 618
Query: 200 EDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCK 259
ED G Y C + G+ + L +++ + T P IS ++++ASLG + I C
Sbjct: 619 EDTGTYTCE-AWNSAGE---VRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCA 674
Query: 260 VFLGTGTPLTTMLW 273
+ G P T+ W
Sbjct: 675 I---AGDPFPTVHW 685
Score = 35.4 bits (80), Expect = 0.091
Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 11/100 (11%)
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLS--VRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQ 217
R + ++ W+++ + L +RGT L++H V ED G Y C T +Q
Sbjct: 57 RGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQ 116
Query: 218 YNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIP 257
+ ++E K+ + + +S +LG R + P
Sbjct: 117 VTVELTVEGSFAKQLGQPV---------VSKTLGDRFSAP 147
Score = 32.0 bits (71), Expect = 1.0
Identities = 39/161 (24%), Positives = 60/161 (37%), Gaps = 6/161 (3%)
Query: 52 QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTR 111
QV + S +P + W N + + +L + ED+GTY C
Sbjct: 570 QVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAW 629
Query: 112 NASYCDKMSIELRVFENTDAFLP-FISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWY 170
N++ + L V E D P FIS P+ +T S ++ +S + W
Sbjct: 630 NSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL---ISCAIAGDPFPTVHWL 686
Query: 171 KDSLLLDKDNEKF--LSVRGTTHLLVHDVALEDAGYYRCVL 209
+D L KD F L L++ V AG Y +L
Sbjct: 687 RDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILL 727
Score = 30.0 bits (66), Expect = 3.8
Identities = 18/64 (28%), Positives = 29/64 (45%), Gaps = 1/64 (1%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL-QEDSGTYVCTTRNASYCDKMSI 121
P +TWH+N T G + ++ A+ +ED G Y C N S ++++
Sbjct: 60 PEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTV 119
Query: 122 ELRV 125
EL V
Sbjct: 120 ELTV 123
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 47.8 bits (112), Expect = 2e-05
Identities = 47/194 (24%), Positives = 77/194 (39%), Gaps = 20/194 (10%)
Query: 93 LWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLV- 151
L + AL ED GTY C NA S + V E + P + T+ + +
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQ 558
Query: 152 -CPDLSEFTRDKTDVKIQ----------WYKDSLLLDKDNEKFLSVRGTTH-LLVHDVAL 199
DL + + +Q W + + + + RGT H L + +V
Sbjct: 559 GLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFP 618
Query: 200 EDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCK 259
ED G Y C + G+ + L +++ + T P IS ++++ASLG + I C
Sbjct: 619 EDTGTYTCE-AWNSAGE---VRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCA 674
Query: 260 VFLGTGTPLTTMLW 273
+ G P T+ W
Sbjct: 675 I---AGDPFPTVHW 685
Score = 35.4 bits (80), Expect = 0.091
Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 11/100 (11%)
Query: 160 RDKTDVKIQWYKDSLLLDKDNEKFLS--VRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQ 217
R + ++ W+++ + L +RGT L++H V ED G Y C T +Q
Sbjct: 57 RGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQ 116
Query: 218 YNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIP 257
+ ++E K+ + + +S +LG R + P
Sbjct: 117 VTVELTVEGSFAKQLGQPV---------VSKTLGDRFSAP 147
Score = 32.0 bits (71), Expect = 1.0
Identities = 39/161 (24%), Positives = 60/161 (37%), Gaps = 6/161 (3%)
Query: 52 QVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTR 111
QV + S +P + W N + + +L + ED+GTY C
Sbjct: 570 QVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAW 629
Query: 112 NASYCDKMSIELRVFENTDAFLP-FISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWY 170
N++ + L V E D P FIS P+ +T S ++ +S + W
Sbjct: 630 NSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL---ISCAIAGDPFPTVHWL 686
Query: 171 KDSLLLDKDNEKF--LSVRGTTHLLVHDVALEDAGYYRCVL 209
+D L KD F L L++ V AG Y +L
Sbjct: 687 RDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILL 727
Score = 30.0 bits (66), Expect = 3.8
Identities = 18/64 (28%), Positives = 29/64 (45%), Gaps = 1/64 (1%)
Query: 63 PRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPAL-QEDSGTYVCTTRNASYCDKMSI 121
P +TWH+N T G + ++ A+ +ED G Y C N S ++++
Sbjct: 60 PEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTV 119
Query: 122 ELRV 125
EL V
Sbjct: 120 ELTV 123
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,768,204
Number of Sequences: 37866
Number of extensions: 723797
Number of successful extensions: 2877
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 151
Number of HSP's that attempted gapping in prelim test: 1962
Number of HSP's gapped (non-prelim): 857
length of query: 398
length of database: 18,247,518
effective HSP length: 104
effective length of query: 294
effective length of database: 14,309,454
effective search space: 4206979476
effective search space used: 4206979476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.