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Search of human proteins with 47157315
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47157315 Janus kinase 3 [Homo sapiens]
(1124 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47157315 Janus kinase 3 [Homo sapiens] 2286 0.0
gi|4826776 Janus kinase 2 [Homo sapiens] 1066 0.0
gi|102469034 janus kinase 1 [Homo sapiens] 765 0.0
gi|187608615 tyrosine kinase 2 [Homo sapiens] 713 0.0
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 184 5e-46
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 184 5e-46
gi|29725609 epidermal growth factor receptor isoform a precursor... 180 8e-45
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 180 8e-45
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 180 8e-45
gi|54792098 erbB-2 isoform b [Homo sapiens] 178 3e-44
gi|54792096 erbB-2 isoform a [Homo sapiens] 178 3e-44
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 162 1e-39
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 162 1e-39
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 161 3e-39
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 161 3e-39
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 160 6e-39
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 160 6e-39
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 160 6e-39
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 159 1e-38
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 159 1e-38
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 159 1e-38
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 159 2e-38
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 157 7e-38
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 155 2e-37
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 155 2e-37
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 155 2e-37
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 155 2e-37
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 155 2e-37
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 155 2e-37
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 155 2e-37
>gi|47157315 Janus kinase 3 [Homo sapiens]
Length = 1124
Score = 2286 bits (5925), Expect = 0.0
Identities = 1124/1124 (100%), Positives = 1124/1124 (100%)
Query: 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKA 60
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKA
Sbjct: 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKA 60
Query: 61 SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL 120
SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL
Sbjct: 61 SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL 120
Query: 121 RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQR 180
RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQR
Sbjct: 121 RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQR 180
Query: 181 PGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM 240
PGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM
Sbjct: 181 PGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM 240
Query: 241 DLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVD 300
DLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVD
Sbjct: 241 DLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVD 300
Query: 301 ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC 360
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC
Sbjct: 301 ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC 360
Query: 361 KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP 420
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP
Sbjct: 361 KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP 420
Query: 421 LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK 480
LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK
Sbjct: 421 LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK 480
Query: 481 EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR 540
EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR
Sbjct: 481 EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR 540
Query: 541 HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ 600
HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ
Sbjct: 541 HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ 600
Query: 601 EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA 660
EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
Sbjct: 601 EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA 660
Query: 661 DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS 720
DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS
Sbjct: 661 DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS 720
Query: 721 GVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL 780
GVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL
Sbjct: 721 GVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL 780
Query: 781 ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR 840
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
Sbjct: 781 ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR 840
Query: 841 YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL 900
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
Sbjct: 841 YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL 900
Query: 901 VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE 960
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
Sbjct: 901 VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE 960
Query: 961 AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL 1020
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
Sbjct: 961 AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL 1020
Query: 1021 FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP 1080
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
Sbjct: 1021 FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP 1080
Query: 1081 SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 1124
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
Sbjct: 1081 SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 1124
>gi|4826776 Janus kinase 2 [Homo sapiens]
Length = 1132
Score = 1066 bits (2757), Expect = 0.0
Identities = 547/1091 (50%), Positives = 747/1091 (68%), Gaps = 26/1091 (2%)
Query: 34 GPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDA 93
G L+F G+++AE++C+ A+KA GI PVYH++FAL +E W+PP+H+F ++++
Sbjct: 48 GKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDES 107
Query: 94 STQVLLYRIRFYFPNWF--GLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLP 151
+ +LYRIRFYFP W+ G + +R G+ + + +LD V+ +LFAQ R D V G +
Sbjct: 108 TRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIK 167
Query: 152 VGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRR 211
V ++ + Q ECL +AVLD+ R+A+E Q P + ++SYK LP +R IQ +TR+
Sbjct: 168 VPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRK 227
Query: 212 RIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGA-LGGHDGLGL 270
RIR RR +++ + C+A +L KY+++LE L A E F V PG+ G +
Sbjct: 228 RIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFAT 287
Query: 271 LRVAGDGGIAWTQGE--------QEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTR 322
+ + G+GGI W++G+ ++ LQ +CDFP I+D+SIKQA + G + E R+VT+ +
Sbjct: 288 IIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEG-SNESRVVTIHK 346
Query: 323 TDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITL 382
D + LE E L EALSFV+L+DGY+RLT D+ H+ CKEVAPP +LE + CHGPI++
Sbjct: 347 QDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISM 406
Query: 383 DFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVG 442
DFAI+KLK G++ G YVLR SP+DF+ + LT V+ +YK CLI ++ + L G
Sbjct: 407 DFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSG 466
Query: 443 LSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRG--HSPPTSSLV 500
+ SSL++LL + D + T CC P+PK+KSNL+V + PTS +
Sbjct: 467 TKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTL 526
Query: 501 QPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVD-GEARKTEVLLKVMD 559
Q + ++QM FHKI + L ++E+LG G+FTKI++G R EV D G+ +TEVLLKV+D
Sbjct: 527 QRPTH--MNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLD 584
Query: 560 AKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLRKRGHL 618
H+N ESF EAAS+MS++S++HLVL +GVC+ GD +VQEFV G++D YL+K +
Sbjct: 585 KAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNC 644
Query: 619 VPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREG--ADGSPPFIKLSDPGVSP 676
+ WKL+V KQLA+A+++LE+ L HGNV A+ +LL RE G+PPFIKLSDPG+S
Sbjct: 645 INILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISI 704
Query: 677 AVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQ 736
VL ++L +RIPWV PEC+ + L+L DKW FG T+WE+ SG P+SALD +KLQ
Sbjct: 705 TVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQ 764
Query: 737 FYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLS--DPTPG 794
FYEDR QLPAPKW ELA LI CM YEP RPSFRA+IRDLNSL + DYELL+ D P
Sbjct: 765 FYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPN 824
Query: 795 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAV 854
R G + + +DPT FEERHLK++ QLGKGNFGSVE+CRYDPL DNTG +VAV
Sbjct: 825 M---RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAV 881
Query: 855 KQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL 914
K+LQHS + RDF+REI+ILK+L D IVKY+GV Y GR++L+L+MEYLP G LRD+L
Sbjct: 882 KKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYL 941
Query: 915 QRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL 974
Q+H+ R+D +LL Y+SQICKGMEYLG++R +HRDLA RNILVE+E VKI DFGL K+L
Sbjct: 942 QKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL 1001
Query: 975 PLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEF 1034
P DK+YY V+EPG+SPIFWYAPESL+++ FS SDVWSFGVVLYELFTY +KS SP AEF
Sbjct: 1002 PQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEF 1061
Query: 1035 LRMMGCERDVPALC-RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGP 1093
+RM+G ++ + L+ELL+ RLP P CP E++ +M CW + RPSF L
Sbjct: 1062 MRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLAL 1121
Query: 1094 QLDMLWSGSRG 1104
++D + G
Sbjct: 1122 RVDQIRDNMAG 1132
>gi|102469034 janus kinase 1 [Homo sapiens]
Length = 1154
Score = 765 bits (1975), Expect = 0.0
Identities = 450/1131 (39%), Positives = 634/1131 (56%), Gaps = 113/1131 (9%)
Query: 41 LSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLY 100
L G++ AE+LC++AA+A I P+ H+LFAL E+ W+ P+ +V+D + L Y
Sbjct: 48 LRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHY 107
Query: 101 RIRFYFPNWFGLE-----------KCHRFGLRKDL---ASAILDLPVLEHLFAQHRSDLV 146
R+RFYF NW G K + G K A+ +LD LE+LFAQ + DLV
Sbjct: 108 RMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLV 167
Query: 147 SGRLPVGLSLKEQ------GECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRD 200
P+ EQ ECL +AVL ++ A + + EL K +SYK +P +L
Sbjct: 168 KCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNK 227
Query: 201 LIQGLSFVTRRRIRRTVRRALRR-----VAACQADRHSLMAKYIMDLERLDPAGAAETFH 255
I+ + +TR RI + L+ + H L KY+ LE L AE F
Sbjct: 228 SIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFE 287
Query: 256 VGL--------PGALGGHDGLGLL----RVAGDGGIAWTQGE------------------ 285
+ +DG +L V G+ GI W
Sbjct: 288 TSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLE 347
Query: 286 ------------QEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFP 333
+E F FPEI I IK++ +V++ + DN+ +E +
Sbjct: 348 NKHKKDEEKNKIREEWNNFSYFPEITHIVIKES----------VVSINKQDNKKMELKLS 397
Query: 334 GLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGG 393
EALSFV+LVDGYFRLT D+ H+ C +VAPP ++ + CHGPI ++AINKL+ G
Sbjct: 398 SHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEG 457
Query: 394 SRPGSYVLRRSPQDFDSFLLTV-CVQNP-----LGPDYKGCLIRRSPTGTFLLVGLSRPH 447
S G YVLR S DFD+ L+TV C + +K I G + L G R
Sbjct: 458 SEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQK-GRYSLHGSDRSF 516
Query: 448 SSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQ 507
SL +L++ L D ++ L CC P+P+E SNL+V T + Q Y
Sbjct: 517 PSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVA-------TKKAQEWQPVYP 569
Query: 508 LSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEA----RKTEVLLKVMDAKHK 563
+SQ++F +I L E+LG G+ T IY G + D E +K +V+LKV+D H+
Sbjct: 570 MSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHR 629
Query: 564 NCMESFLEAASLMSQVSYRHLVLLHGVCMAG-DSTMVQEFVHLGAIDMYLRKRGHLVPAS 622
+ +F EAAS+M QVS++H+V L+GVC+ ++ MV+EFV G +D+++ ++ ++
Sbjct: 630 DISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTP 689
Query: 623 WKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGS-PPFIKLSDPGVSPAVLSL 681
WK +V KQLA AL+YLEDK L HGNV + +LLAREG D PFIKLSDPG+ VLS
Sbjct: 690 WKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSR 749
Query: 682 EMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDR 741
+ +RIPW+APEC+ +++ LS+ ADKW FG T+WE+ +P+ +K +FYE R
Sbjct: 750 QECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESR 809
Query: 742 QQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDG 801
+ P ELA L+ +CM Y+P QRP FRA++RD+N L + +++S+ P
Sbjct: 810 CRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEV---- 865
Query: 802 LWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HS 860
DPT FE+R LK I LG+G+FG VELCRYDP GDNTG VAVK L+ S
Sbjct: 866 -----------DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES 914
Query: 861 GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR 920
G + D ++EI+IL+ L+ + IVKY+G+ G ++L+ME+LPSG L+++L +++ +
Sbjct: 915 GGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK 974
Query: 921 LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDY 980
++ + L Y+ QICKGM+YLGSR+ VHRDLAARN+LVESE VKI DFGL K + DK+Y
Sbjct: 975 INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEY 1034
Query: 981 YVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGC 1040
Y V++ SP+FWYAPE L + F SDVWSFGV L+EL TYCD SP A FL+M+G
Sbjct: 1035 YTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGP 1094
Query: 1041 ERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 1091
+ RL+ L+EG+RLP PP CP EV++LM+ CW P +R SF L
Sbjct: 1095 THGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNL 1145
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/283 (21%), Positives = 133/283 (46%), Gaps = 36/283 (12%)
Query: 526 NLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHK-NCMESFLEAASLMSQVSYRHL 584
+LG G F K+ CR++ +G+ +V +K + + N + + ++ + + ++
Sbjct: 880 DLGEGHFGKVEL-CRYDP-EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENI 937
Query: 585 VLLHGVCMAGDST---MVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDK 641
V G+C ++ EF+ G++ YL K + + +L+ Q+ ++YL +
Sbjct: 938 VKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSR 997
Query: 642 GLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLS----LEMLTDR---IPWVAPE 694
H +++AR VL+ E +K+ D G++ A+ + + DR + W APE
Sbjct: 998 QYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPE 1051
Query: 695 CLREAQTLSLEADKWGFGATVWEVF-------SGVTMPISALDPA-------KKLQFYED 740
CL +++ + +D W FG T+ E+ S + + + + P + + ++
Sbjct: 1052 CLMQSK-FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKE 1110
Query: 741 RQQLPAPKWT--ELALLIQQCMAYEPVQRPSFRAVIRDLNSLI 781
++LP P E+ L+++C ++P R SF+ +I +L+
Sbjct: 1111 GKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
Score = 55.5 bits (132), Expect = 3e-07
Identities = 53/207 (25%), Positives = 88/207 (42%), Gaps = 31/207 (14%)
Query: 900 LVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES 959
+V E++ G L F+ R L + Q+ + YL + VH ++ +N+L+
Sbjct: 665 MVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAR 724
Query: 960 EA-------HVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNI-FSRQSDVW 1011
E +K++D G+ + L + + R P W APE + D+ S +D W
Sbjct: 725 EGIDSECGPFIKLSDPGIP-ITVLSRQECIERIP------WIAPECVEDSKNLSVAADKW 777
Query: 1012 SFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVH 1071
SFG L+E+ C P + ++ ER + CR P P+C E+
Sbjct: 778 SFGTTLWEI---CYNGEIPLKD-KTLIEKERFYESRCR-----------PVTPSCK-ELA 821
Query: 1072 ELMKLCWAPSPQDRPSFSALGPQLDML 1098
+LM C P RP F A+ ++ L
Sbjct: 822 DLMTRCMNYDPNQRPFFRAIMRDINKL 848
>gi|187608615 tyrosine kinase 2 [Homo sapiens]
Length = 1187
Score = 713 bits (1841), Expect = 0.0
Identities = 459/1198 (38%), Positives = 629/1198 (52%), Gaps = 148/1198 (12%)
Query: 24 GALHVLLPARGPGPPQR-LSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWF 82
G L VLL GPG + ++FS AE++C+ A GI P +LFAL W
Sbjct: 26 GGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWL 85
Query: 83 PPSHIFSVEDASTQVLLYRIRFYFPNWFGLEK----CHRFGLRKDLASA--------ILD 130
PP+HI + ++ +L +RIRFYF NW G+ +R G AS+ +LD
Sbjct: 86 PPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLD 145
Query: 131 LPVLEHLFAQHRSDLVSGRLPVG-LSLKEQ-----GECLSLAVLDLARMAREQAQRPGEL 184
E+LF Q + + V+ + LS +E+ E L +A L L +A E+
Sbjct: 146 PASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEV 205
Query: 185 LKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLER 244
K S+K C+P S R I+ S +TR R+R RR LR + + +M KY+ LER
Sbjct: 206 AKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLER 265
Query: 245 LDPAGAAETF---HVGL-----------------PGALGGHDGLGL----LRVAGDGGIA 280
L P E H+ L P G G + V G GGI
Sbjct: 266 LAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQ 325
Query: 281 WTQGEQEVL-----------------------------QP-----------FCDFPEIVD 300
W E+EV QP FCDF +I
Sbjct: 326 WWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITH 385
Query: 301 ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC 360
+ +K+ V++ R DN+ LE P ALSFV+LVDGYFRLT DS H+ C
Sbjct: 386 VVLKE----------HCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLC 435
Query: 361 KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP 420
EVAPPRL+ + + HGP+ F KL+ G Y++ S +LTV ++
Sbjct: 436 HEVAPPRLVMSIRDGIHGPLLEPFVQAKLRP---EDGLYLIHWSTSHPYRLILTVAQRSQ 492
Query: 421 LGPDYKGCLIRRSPT----GTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCI 476
+ +R+ P G F+L G R S+REL A L +L CC+
Sbjct: 493 APDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCL 552
Query: 477 PRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIY 536
P+P E SNLI+++ + P + LSQ++FH++ + +LG G+ T +Y
Sbjct: 553 PQPGETSNLIIMRGARASPRT--------LNLSQLSFHRVDQKEITQLSHLGQGTRTNVY 604
Query: 537 RGC----------------RHEVVDGEARKTE--VLLKVMDAKHKNCMESFLEAASLMSQ 578
G +V G R E V+LKV+D H + +F E ASLMSQ
Sbjct: 605 EGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQ 664
Query: 579 VSYRHLVLLHGVCMAG-DSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALN 636
VS+ HL +HGVC+ G ++ MV E+V G +D++LR+ RGH VP +WK+ V +QLA AL+
Sbjct: 665 VSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGH-VPMAWKMVVAQQLASALS 723
Query: 637 YLEDKGLPHGNVSARKVLLAREG-ADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPEC 695
YLE+K L HGNV R +LLAR G A+G+ PFIKLSDPGV LS E +RIPW+APEC
Sbjct: 724 YLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPEC 783
Query: 696 LRE-AQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELAL 754
L A +LS DKWGFGAT+ E+ P+ + P++K FY+ + +LP P +LA
Sbjct: 784 LPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT 843
Query: 755 LIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDP 814
L QC+ YEP QRPSFR ++RDL L + + P + A DP
Sbjct: 844 LTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPA--------------SDP 889
Query: 815 TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS-GPDQQRDFQREIQ 873
T+F +R+LK I LG+G+FG V L YDP D TG +VAVK L+ GP + +++EI
Sbjct: 890 TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEID 949
Query: 874 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQI 933
IL+ L+ + I+KY+G G +SL+LVMEY+P G LRD+L RH L ++LLL++ QI
Sbjct: 950 ILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGL--AQLLLFAQQI 1007
Query: 934 CKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFW 993
C+GM YL ++ +HRDLAARN+L++++ VKI DFGLAK +P +YY VRE G SP+FW
Sbjct: 1008 CEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 1067
Query: 994 YAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLEL 1053
YAPE L + F SDVWSFGV LYEL T+CD S SP +FL ++G + + RL EL
Sbjct: 1068 YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL 1127
Query: 1054 LEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFT 1111
LE G+RLP P CP EV+ LMK CW RP+F L P L + +G F+
Sbjct: 1128 LERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFS 1185
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 184 bits (466), Expect = 5e-46
Identities = 117/314 (37%), Positives = 165/314 (52%), Gaps = 30/314 (9%)
Query: 786 ELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLG 845
EL+ TP AP N AQL I +E LK + LG G FG+V + P G
Sbjct: 693 ELVEPLTPSGTAP-----NQAQL------RILKETELKRVKVLGSGAFGTVYKGIWVPEG 741
Query: 846 DNTGALVAVKQLQHS-GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEY 904
+ VA+K L + GP +F E I+ ++ +V+ GV P +++LV +
Sbjct: 742 ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSP---TIQLVTQL 798
Query: 905 LPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVK 964
+P GCL +++ H+ + + LL + QI KGM YL RR VHRDLAARN+LV+S HVK
Sbjct: 799 MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVK 858
Query: 965 IADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYC 1024
I DFGLA+LL D+ Y + G+ PI W A E + F+ QSDVWS+GV ++EL T+
Sbjct: 859 ITDFGLARLLEGDEKEYNA-DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFG 917
Query: 1025 DKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQD 1084
K R++P +LLE+G+RLP PP C +V+ +M CW
Sbjct: 918 GKPYDGIP--------TREIP------DLLEKGERLPQPPICTIDVYMVMVKCWMIDADS 963
Query: 1085 RPSFSALGPQLDML 1098
RP F L + +
Sbjct: 964 RPKFKELAAEFSRM 977
Score = 91.7 bits (226), Expect = 4e-18
Identities = 111/465 (23%), Positives = 195/465 (41%), Gaps = 53/465 (11%)
Query: 344 LVDGYFRLTTDSQHFFCKEVAPP-RLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLR 402
L DG FR + C E P +E+ CHGP N K + G +
Sbjct: 538 LYDGEFREFENGS--ICVECDPQCEKMEDGLLTCHGP----GPDNCTKCSHFKDGPNCVE 591
Query: 403 RSP---QDFDSFLLTV-------------CVQNPLGPDYKGCLIRRSPTGTFLLVGLSRP 446
+ P Q +SF+ C Q GP C I TG L P
Sbjct: 592 KCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC-IYYPWTGHSTL-----P 645
Query: 447 HSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQP--QS 504
+ L+A GGL + V V LT R K ++R + LV+P S
Sbjct: 646 QHARTPLIAAGVIGGLFIL-VIVGLTFAVYVRRKSIKKKRALRRFLE---TELVEPLTPS 701
Query: 505 QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM-DAKHK 563
+Q + L+ + LG G+F +Y+G V +GE K V +K++ +
Sbjct: 702 GTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIW--VPEGETVKIPVAIKILNETTGP 759
Query: 564 NCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASW 623
F++ A +M+ + + HLV L GVC++ +V + + G + Y+ + + +
Sbjct: 760 KANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQL 819
Query: 624 KLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEM 683
L Q+A + YLE++ L H +++AR VL+ SP +K++D G++ + E
Sbjct: 820 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVK------SPNHVKITDFGLARLLEGDEK 873
Query: 684 LTDR------IPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQF 737
+ I W+A EC+ + + ++D W +G T+WE+ + P + +
Sbjct: 874 EYNADGGKMPIKWMALECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDL 932
Query: 738 YEDRQQLPAPK--WTELALLIQQCMAYEPVQRPSFRAVIRDLNSL 780
E ++LP P ++ +++ +C + RP F+ + + + +
Sbjct: 933 LEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRM 977
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 184 bits (466), Expect = 5e-46
Identities = 117/314 (37%), Positives = 165/314 (52%), Gaps = 30/314 (9%)
Query: 786 ELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLG 845
EL+ TP AP N AQL I +E LK + LG G FG+V + P G
Sbjct: 693 ELVEPLTPSGTAP-----NQAQL------RILKETELKRVKVLGSGAFGTVYKGIWVPEG 741
Query: 846 DNTGALVAVKQLQHS-GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEY 904
+ VA+K L + GP +F E I+ ++ +V+ GV P +++LV +
Sbjct: 742 ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSP---TIQLVTQL 798
Query: 905 LPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVK 964
+P GCL +++ H+ + + LL + QI KGM YL RR VHRDLAARN+LV+S HVK
Sbjct: 799 MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVK 858
Query: 965 IADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYC 1024
I DFGLA+LL D+ Y + G+ PI W A E + F+ QSDVWS+GV ++EL T+
Sbjct: 859 ITDFGLARLLEGDEKEYNA-DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFG 917
Query: 1025 DKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQD 1084
K R++P +LLE+G+RLP PP C +V+ +M CW
Sbjct: 918 GKPYDGIP--------TREIP------DLLEKGERLPQPPICTIDVYMVMVKCWMIDADS 963
Query: 1085 RPSFSALGPQLDML 1098
RP F L + +
Sbjct: 964 RPKFKELAAEFSRM 977
Score = 91.7 bits (226), Expect = 4e-18
Identities = 111/465 (23%), Positives = 195/465 (41%), Gaps = 53/465 (11%)
Query: 344 LVDGYFRLTTDSQHFFCKEVAPP-RLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLR 402
L DG FR + C E P +E+ CHGP N K + G +
Sbjct: 538 LYDGEFREFENGS--ICVECDPQCEKMEDGLLTCHGP----GPDNCTKCSHFKDGPNCVE 591
Query: 403 RSP---QDFDSFLLTV-------------CVQNPLGPDYKGCLIRRSPTGTFLLVGLSRP 446
+ P Q +SF+ C Q GP C I TG L P
Sbjct: 592 KCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC-IYYPWTGHSTL-----P 645
Query: 447 HSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQP--QS 504
+ L+A GGL + V V LT R K ++R + LV+P S
Sbjct: 646 QHARTPLIAAGVIGGLFIL-VIVGLTFAVYVRRKSIKKKRALRRFLE---TELVEPLTPS 701
Query: 505 QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM-DAKHK 563
+Q + L+ + LG G+F +Y+G V +GE K V +K++ +
Sbjct: 702 GTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIW--VPEGETVKIPVAIKILNETTGP 759
Query: 564 NCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASW 623
F++ A +M+ + + HLV L GVC++ +V + + G + Y+ + + +
Sbjct: 760 KANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQL 819
Query: 624 KLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEM 683
L Q+A + YLE++ L H +++AR VL+ SP +K++D G++ + E
Sbjct: 820 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVK------SPNHVKITDFGLARLLEGDEK 873
Query: 684 LTDR------IPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQF 737
+ I W+A EC+ + + ++D W +G T+WE+ + P + +
Sbjct: 874 EYNADGGKMPIKWMALECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDL 932
Query: 738 YEDRQQLPAPK--WTELALLIQQCMAYEPVQRPSFRAVIRDLNSL 780
E ++LP P ++ +++ +C + RP F+ + + + +
Sbjct: 933 LEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRM 977
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 180 bits (456), Expect = 8e-45
Identities = 112/319 (35%), Positives = 168/319 (52%), Gaps = 33/319 (10%)
Query: 775 RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFG 834
R L L+ + EL+ TP AP L I +E K I LG G FG
Sbjct: 677 RTLRRLLQ-ERELVEPLTPSGEAPNQALLR-----------ILKETEFKKIKVLGSGAFG 724
Query: 835 SVELCRYDPLGDNTGALVAVKQLQHS-GPDQQRDFQREIQILKALHSDFIVKYRGVSYGP 893
+V + P G+ VA+K+L+ + P ++ E ++ ++ + + + G+
Sbjct: 725 TVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICL-- 782
Query: 894 GRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAAR 953
+++L+ + +P GCL D+++ H+ + + LL + QI KGM YL RR VHRDLAAR
Sbjct: 783 -TSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAAR 841
Query: 954 NILVESEAHVKIADFGLAKLLPL-DKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWS 1012
N+LV++ HVKI DFGLAKLL +K+Y+ E G+ PI W A ES+ I++ QSDVWS
Sbjct: 842 NVLVKTPQHVKITDFGLAKLLGAEEKEYHA--EGGKVPIKWMALESILHRIYTHQSDVWS 899
Query: 1013 FGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHE 1072
+GV ++EL T+ K +PA + +LE+G+RLP PP C +V+
Sbjct: 900 YGVTVWELMTFGSKPYD-------------GIPA-SEISSILEKGERLPQPPICTIDVYM 945
Query: 1073 LMKLCWAPSPQDRPSFSAL 1091
+M CW RP F L
Sbjct: 946 IMVKCWMIDADSRPKFREL 964
Score = 94.0 bits (232), Expect = 7e-19
Identities = 64/263 (24%), Positives = 130/263 (49%), Gaps = 18/263 (6%)
Query: 527 LGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM-DAKHKNCMESFLEAASLMSQVSYRHLV 585
LG G+F +Y+G + +GE K V +K + +A + L+ A +M+ V H+
Sbjct: 718 LGSGAFGTVYKGLW--IPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 775
Query: 586 LLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPH 645
L G+C+ ++ + + G + Y+R+ + + + L Q+A +NYLED+ L H
Sbjct: 776 RLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVH 835
Query: 646 GNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR------IPWVAPECLREA 699
+++AR VL+ +P +K++D G++ + + E I W+A E +
Sbjct: 836 RDLAARNVLVK------TPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILH- 888
Query: 700 QTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPK--WTELALLIQ 757
+ + ++D W +G TVWE+ + + P + ++ E ++LP P ++ +++
Sbjct: 889 RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMV 948
Query: 758 QCMAYEPVQRPSFRAVIRDLNSL 780
+C + RP FR +I + + +
Sbjct: 949 KCWMIDADSRPKFRELIIEFSKM 971
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sapiens]
Length = 1038
Score = 180 bits (456), Expect = 8e-45
Identities = 112/306 (36%), Positives = 166/306 (54%), Gaps = 28/306 (9%)
Query: 789 SDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNT 848
+ P PG A L Q C + E+ L+ + +LG G+FG V +D T
Sbjct: 101 TSPAPGGPAGEGPL----QSLTC----LIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKT 152
Query: 849 GALVAVKQLQH---SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYL 905
+ VAVK L+ S P+ DF RE+ + +L +++ GV P +++V E
Sbjct: 153 VS-VAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP---PMKMVTELA 208
Query: 906 PSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKI 965
P G L D L++H+ L Y+ Q+ +GM YL S+R +HRDLAARN+L+ + VKI
Sbjct: 209 PLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKI 268
Query: 966 ADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCD 1025
DFGL + LP + D+YV++E + P W APESL FS SD W FGV L+E+FTY
Sbjct: 269 GDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQ 328
Query: 1026 KSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDR 1085
+ ++ + G + L ++ +EG+RLP P CP +++ +M CWA P+DR
Sbjct: 329 E------PWIGLNGSQ-------ILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDR 375
Query: 1086 PSFSAL 1091
P+F AL
Sbjct: 376 PTFVAL 381
Score = 93.2 bits (230), Expect = 1e-18
Identities = 81/278 (29%), Positives = 134/278 (48%), Gaps = 21/278 (7%)
Query: 525 ENLGHGSFTKIYRGCRHEVVDGEARKTEV-LLKVMDAKHKNCMESFLEAASLMSQVSYRH 583
E LG GSF + RG + G+ V LK M+ F+ + M + +R+
Sbjct: 130 EKLGDGSFGVVRRG-EWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 188
Query: 584 LVLLHGVCMAGDSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALNYLEDKG 642
L+ L+GV + MV E LG++ LRK +GH + + V Q+A + YLE K
Sbjct: 189 LIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV-QVAEGMGYLESKR 247
Query: 643 LPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAV-------LSLEMLTDRIPWVAPEC 695
H +++AR +LLA + +K+ D G+ A+ + E W APE
Sbjct: 248 FIHRDLAARNLLLA------TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 301
Query: 696 LREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKL-QFYEDRQQLPAPK--WTEL 752
L+ +T S +D W FG T+WE+F+ P L+ ++ L + ++ ++LP P+ ++
Sbjct: 302 LK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI 360
Query: 753 ALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSD 790
++ QC A++P RP+F A+ L +D L D
Sbjct: 361 YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQD 398
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sapiens]
Length = 1086
Score = 180 bits (456), Expect = 8e-45
Identities = 112/306 (36%), Positives = 166/306 (54%), Gaps = 28/306 (9%)
Query: 789 SDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNT 848
+ P PG A L Q C + E+ L+ + +LG G+FG V +D T
Sbjct: 164 TSPAPGGPAGEGPL----QSLTC----LIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKT 215
Query: 849 GALVAVKQLQH---SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYL 905
+ VAVK L+ S P+ DF RE+ + +L +++ GV P +++V E
Sbjct: 216 VS-VAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP---PMKMVTELA 271
Query: 906 PSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKI 965
P G L D L++H+ L Y+ Q+ +GM YL S+R +HRDLAARN+L+ + VKI
Sbjct: 272 PLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKI 331
Query: 966 ADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCD 1025
DFGL + LP + D+YV++E + P W APESL FS SD W FGV L+E+FTY
Sbjct: 332 GDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQ 391
Query: 1026 KSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDR 1085
+ ++ + G + L ++ +EG+RLP P CP +++ +M CWA P+DR
Sbjct: 392 E------PWIGLNGSQ-------ILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDR 438
Query: 1086 PSFSAL 1091
P+F AL
Sbjct: 439 PTFVAL 444
Score = 93.2 bits (230), Expect = 1e-18
Identities = 81/278 (29%), Positives = 134/278 (48%), Gaps = 21/278 (7%)
Query: 525 ENLGHGSFTKIYRGCRHEVVDGEARKTEV-LLKVMDAKHKNCMESFLEAASLMSQVSYRH 583
E LG GSF + RG + G+ V LK M+ F+ + M + +R+
Sbjct: 193 EKLGDGSFGVVRRG-EWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 251
Query: 584 LVLLHGVCMAGDSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALNYLEDKG 642
L+ L+GV + MV E LG++ LRK +GH + + V Q+A + YLE K
Sbjct: 252 LIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV-QVAEGMGYLESKR 310
Query: 643 LPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAV-------LSLEMLTDRIPWVAPEC 695
H +++AR +LLA + +K+ D G+ A+ + E W APE
Sbjct: 311 FIHRDLAARNLLLA------TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 364
Query: 696 LREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKL-QFYEDRQQLPAPK--WTEL 752
L+ +T S +D W FG T+WE+F+ P L+ ++ L + ++ ++LP P+ ++
Sbjct: 365 LK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI 423
Query: 753 ALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSD 790
++ QC A++P RP+F A+ L +D L D
Sbjct: 424 YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQD 461
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 178 bits (451), Expect = 3e-44
Identities = 110/297 (37%), Positives = 163/297 (54%), Gaps = 25/297 (8%)
Query: 796 LAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVK 855
L P + N AQ+ I +E L+ + LG G FG+V + P G+N VA+K
Sbjct: 670 LTPSGAMPNQAQM------RILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIK 723
Query: 856 QL-QHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL 914
L +++ P ++ E ++ + S ++ + G+ +++LV + +P GCL D +
Sbjct: 724 VLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHV 780
Query: 915 QRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL 974
+ +R RL + LL + QI KGM YL R VHRDLAARN+LV+S HVKI DFGLA+LL
Sbjct: 781 RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 840
Query: 975 PLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEF 1034
+D+ Y + G+ PI W A ES+ F+ QSDVWS+GV ++EL T+ K
Sbjct: 841 DIDETEYHA-DGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIP-- 897
Query: 1035 LRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 1091
R++P +LLE+G+RLP PP C +V+ +M CW + RP F L
Sbjct: 898 ------AREIP------DLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFREL 942
Score = 81.6 bits (200), Expect = 4e-15
Identities = 64/263 (24%), Positives = 126/263 (47%), Gaps = 18/263 (6%)
Query: 527 LGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM-DAKHKNCMESFLEAASLMSQVSYRHLV 585
LG G+F +Y+G + DGE K V +KV+ + + L+ A +M+ V ++
Sbjct: 696 LGSGAFGTVYKGIW--IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 753
Query: 586 LLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPH 645
L G+C+ +V + + G + ++R+ + + L Q+A ++YLED L H
Sbjct: 754 RLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVH 813
Query: 646 GNVSARKVLLAREGADGSPPFIKLSDPGVSPA--VLSLEMLTD----RIPWVAPECLREA 699
+++AR VL+ SP +K++D G++ + E D I W+A E +
Sbjct: 814 RDLAARNVLVK------SPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILR- 866
Query: 700 QTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPK--WTELALLIQ 757
+ + ++D W +G TVWE+ + P + + E ++LP P ++ +++
Sbjct: 867 RRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMV 926
Query: 758 QCMAYEPVQRPSFRAVIRDLNSL 780
+C + RP FR ++ + + +
Sbjct: 927 KCWMIDSECRPRFRELVSEFSRM 949
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 178 bits (451), Expect = 3e-44
Identities = 110/297 (37%), Positives = 163/297 (54%), Gaps = 25/297 (8%)
Query: 796 LAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVK 855
L P + N AQ+ I +E L+ + LG G FG+V + P G+N VA+K
Sbjct: 700 LTPSGAMPNQAQM------RILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIK 753
Query: 856 QL-QHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL 914
L +++ P ++ E ++ + S ++ + G+ +++LV + +P GCL D +
Sbjct: 754 VLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHV 810
Query: 915 QRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL 974
+ +R RL + LL + QI KGM YL R VHRDLAARN+LV+S HVKI DFGLA+LL
Sbjct: 811 RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 870
Query: 975 PLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEF 1034
+D+ Y + G+ PI W A ES+ F+ QSDVWS+GV ++EL T+ K
Sbjct: 871 DIDETEYHA-DGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIP-- 927
Query: 1035 LRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 1091
R++P +LLE+G+RLP PP C +V+ +M CW + RP F L
Sbjct: 928 ------AREIP------DLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFREL 972
Score = 81.6 bits (200), Expect = 4e-15
Identities = 64/263 (24%), Positives = 126/263 (47%), Gaps = 18/263 (6%)
Query: 527 LGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM-DAKHKNCMESFLEAASLMSQVSYRHLV 585
LG G+F +Y+G + DGE K V +KV+ + + L+ A +M+ V ++
Sbjct: 726 LGSGAFGTVYKGIW--IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 783
Query: 586 LLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPH 645
L G+C+ +V + + G + ++R+ + + L Q+A ++YLED L H
Sbjct: 784 RLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVH 843
Query: 646 GNVSARKVLLAREGADGSPPFIKLSDPGVSPA--VLSLEMLTD----RIPWVAPECLREA 699
+++AR VL+ SP +K++D G++ + E D I W+A E +
Sbjct: 844 RDLAARNVLVK------SPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILR- 896
Query: 700 QTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPK--WTELALLIQ 757
+ + ++D W +G TVWE+ + P + + E ++LP P ++ +++
Sbjct: 897 RRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMV 956
Query: 758 QCMAYEPVQRPSFRAVIRDLNSL 780
+C + RP FR ++ + + +
Sbjct: 957 KCWMIDSECRPRFRELVSEFSRM 979
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 162 bits (411), Expect = 1e-39
Identities = 103/280 (36%), Positives = 148/280 (52%), Gaps = 22/280 (7%)
Query: 812 QDPTIFEERHLKYIS--QLGKGNFGSVELCRYDPLGDNTGALVAVKQL-QHSGPDQQRDF 868
+D +F +R I+ +LG GNFGSV Y VA+K L Q + +
Sbjct: 19 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEM 76
Query: 869 QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLL 928
RE QI+ L + +IV+ GV ++L LVME G L FL R + S +
Sbjct: 77 MREAQIMHQLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE 133
Query: 929 YSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQ 988
Q+ GM+YL + VHRDLAARN+L+ + + KI+DFGL+K L D YY R G+
Sbjct: 134 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 193
Query: 989 SPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALC 1048
P+ WYAPE ++ FS +SDVWS+GV ++E +Y K + +M G E
Sbjct: 194 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQK------PYKKMKGPE------- 240
Query: 1049 RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSF 1088
++ +E+G+R+ PP CP E++ LM CW +DRP F
Sbjct: 241 -VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
Score = 92.4 bits (228), Expect = 2e-18
Identities = 72/257 (28%), Positives = 116/257 (45%), Gaps = 21/257 (8%)
Query: 527 LGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM-DAKHKNCMESFLEAASLMSQVSYRHLV 585
LG G+F + +G V ++ +V +KV+ K E + A +M Q+ ++V
Sbjct: 37 LGCGNFGSVRQG----VYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 92
Query: 586 LLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPH 645
L GVC A +V E G + +L + +P S +++ Q++ + YLE+K H
Sbjct: 93 RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 152
Query: 646 GNVSARKVLLAREGADGSPPFIKLSDPGVSPAV-LSLEMLTDR------IPWVAPECLRE 698
+++AR VLL + K+SD G+S A+ T R + W APEC+
Sbjct: 153 RDLAARNVLLVNR------HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-N 205
Query: 699 AQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYED--RQQLPAPKWTELALLI 756
+ S +D W +G T+WE S P + + + F E R + P EL L+
Sbjct: 206 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 265
Query: 757 QQCMAYEPVQRPSFRAV 773
C Y+ RP F V
Sbjct: 266 SDCWIYKWEDRPDFLTV 282
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 162 bits (411), Expect = 1e-39
Identities = 103/280 (36%), Positives = 148/280 (52%), Gaps = 22/280 (7%)
Query: 812 QDPTIFEERHLKYIS--QLGKGNFGSVELCRYDPLGDNTGALVAVKQL-QHSGPDQQRDF 868
+D +F +R I+ +LG GNFGSV Y VA+K L Q + +
Sbjct: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEM 383
Query: 869 QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLL 928
RE QI+ L + +IV+ GV ++L LVME G L FL R + S +
Sbjct: 384 MREAQIMHQLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE 440
Query: 929 YSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQ 988
Q+ GM+YL + VHRDLAARN+L+ + + KI+DFGL+K L D YY R G+
Sbjct: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500
Query: 989 SPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALC 1048
P+ WYAPE ++ FS +SDVWS+GV ++E +Y K + +M G E
Sbjct: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQK------PYKKMKGPE------- 547
Query: 1049 RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSF 1088
++ +E+G+R+ PP CP E++ LM CW +DRP F
Sbjct: 548 -VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586
Score = 92.4 bits (228), Expect = 2e-18
Identities = 72/257 (28%), Positives = 116/257 (45%), Gaps = 21/257 (8%)
Query: 527 LGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM-DAKHKNCMESFLEAASLMSQVSYRHLV 585
LG G+F + +G V ++ +V +KV+ K E + A +M Q+ ++V
Sbjct: 344 LGCGNFGSVRQG----VYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399
Query: 586 LLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPH 645
L GVC A +V E G + +L + +P S +++ Q++ + YLE+K H
Sbjct: 400 RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459
Query: 646 GNVSARKVLLAREGADGSPPFIKLSDPGVSPAV-LSLEMLTDR------IPWVAPECLRE 698
+++AR VLL + K+SD G+S A+ T R + W APEC+
Sbjct: 460 RDLAARNVLLVNR------HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-N 512
Query: 699 AQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYED--RQQLPAPKWTELALLI 756
+ S +D W +G T+WE S P + + + F E R + P EL L+
Sbjct: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572
Query: 757 QQCMAYEPVQRPSFRAV 773
C Y+ RP F V
Sbjct: 573 SDCWIYKWEDRPDFLTV 589
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 161 bits (408), Expect = 3e-39
Identities = 94/265 (35%), Positives = 150/265 (56%), Gaps = 18/265 (6%)
Query: 827 QLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKY 886
+LG GNFG+V+ Y V + + + + P + + E +++ L + +IV+
Sbjct: 353 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412
Query: 887 RGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCV 946
G+ +S LVME G L +LQ++R D + + L Q+ GM+YL V
Sbjct: 413 IGICEA---ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH-QVSMGMKYLEESNFV 468
Query: 947 HRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSR 1006
HRDLAARN+L+ ++ + KI+DFGL+K L D++YY + G+ P+ WYAPE ++ FS
Sbjct: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
Query: 1007 QSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPAC 1066
+SDVWSFGV+++E F+Y K + M G E + +LE+G+R+ P C
Sbjct: 529 KSDVWSFGVLMWEAFSYGQK------PYRGMKGSE--------VTAMLEKGERMGCPAGC 574
Query: 1067 PAEVHELMKLCWAPSPQDRPSFSAL 1091
P E+++LM LCW ++RP F+A+
Sbjct: 575 PREMYDLMNLCWTYDVENRPGFAAV 599
Score = 93.2 bits (230), Expect = 1e-18
Identities = 68/258 (26%), Positives = 121/258 (46%), Gaps = 19/258 (7%)
Query: 525 ENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHL 584
+ LG G+F + +G + + + V + +A + L A++M Q+ ++
Sbjct: 352 KELGSGNFGTVKKG--YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409
Query: 585 VLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLP 644
V + G+C A +V E LG ++ YL++ H+ + +++V Q++ + YLE+
Sbjct: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKN-IIELVHQVSMGMKYLEESNFV 468
Query: 645 HGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR-------IPWVAPECLR 697
H +++AR VLL + + K+SD G+S A+ + E + W APEC+
Sbjct: 469 HRDLAARNVLLVTQ------HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 522
Query: 698 EAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYE--DRQQLPAPKWTELALL 755
+ S ++D W FG +WE FS P + ++ E +R PA E+ L
Sbjct: 523 YYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 581
Query: 756 IQQCMAYEPVQRPSFRAV 773
+ C Y+ RP F AV
Sbjct: 582 MNLCWTYDVENRPGFAAV 599
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 161 bits (408), Expect = 3e-39
Identities = 94/265 (35%), Positives = 150/265 (56%), Gaps = 18/265 (6%)
Query: 827 QLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKY 886
+LG GNFG+V+ Y V + + + + P + + E +++ L + +IV+
Sbjct: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435
Query: 887 RGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCV 946
G+ +S LVME G L +LQ++R D + + L Q+ GM+YL V
Sbjct: 436 IGICEA---ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH-QVSMGMKYLEESNFV 491
Query: 947 HRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSR 1006
HRDLAARN+L+ ++ + KI+DFGL+K L D++YY + G+ P+ WYAPE ++ FS
Sbjct: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
Query: 1007 QSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPAC 1066
+SDVWSFGV+++E F+Y K + M G E + +LE+G+R+ P C
Sbjct: 552 KSDVWSFGVLMWEAFSYGQK------PYRGMKGSE--------VTAMLEKGERMGCPAGC 597
Query: 1067 PAEVHELMKLCWAPSPQDRPSFSAL 1091
P E+++LM LCW ++RP F+A+
Sbjct: 598 PREMYDLMNLCWTYDVENRPGFAAV 622
Score = 93.2 bits (230), Expect = 1e-18
Identities = 68/258 (26%), Positives = 121/258 (46%), Gaps = 19/258 (7%)
Query: 525 ENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHL 584
+ LG G+F + +G + + + V + +A + L A++M Q+ ++
Sbjct: 375 KELGSGNFGTVKKG--YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432
Query: 585 VLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLP 644
V + G+C A +V E LG ++ YL++ H+ + +++V Q++ + YLE+
Sbjct: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKN-IIELVHQVSMGMKYLEESNFV 491
Query: 645 HGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR-------IPWVAPECLR 697
H +++AR VLL + + K+SD G+S A+ + E + W APEC+
Sbjct: 492 HRDLAARNVLLVTQ------HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545
Query: 698 EAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYE--DRQQLPAPKWTELALL 755
+ S ++D W FG +WE FS P + ++ E +R PA E+ L
Sbjct: 546 YYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604
Query: 756 IQQCMAYEPVQRPSFRAV 773
+ C Y+ RP F AV
Sbjct: 605 MNLCWTYDVENRPGFAAV 622
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 160 bits (405), Expect = 6e-39
Identities = 116/337 (34%), Positives = 164/337 (48%), Gaps = 58/337 (17%)
Query: 788 LSDPTPGALA-------PRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSV---E 837
LS P LA P D LW F L LG+G FG V E
Sbjct: 398 LSSSGPALLAGLVSLDLPLDPLWE------------FPRDRLVLGKPLGEGCFGQVVRAE 445
Query: 838 LCRYDPLGDNTGALVAVKQLQHSGPDQQ-RDFQREIQILKAL--HSDFIVKYRGVSYGPG 894
DP + + VAVK L+ + D+ D E++++K + H + I+ GV G
Sbjct: 446 AFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN-IINLLGVCTQEG 504
Query: 895 RQSLRLVMEYLPSGCLRDFLQRHR---------------ARLDASRLLLYSSQICKGMEY 939
L +++E G LR+FL+ R L L+ + Q+ +GM+Y
Sbjct: 505 --PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQY 562
Query: 940 LGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESL 999
L SR+C+HRDLAARN+LV + +KIADFGLA+ + DYY G+ P+ W APE+L
Sbjct: 563 LESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH-HIDYYKKTSNGRLPVKWMAPEAL 621
Query: 1000 SDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQR 1059
D +++ QSDVWSFG++L+E+FT + G + L LL EG R
Sbjct: 622 FDRVYTHQSDVWSFGILLWEIFT--------------LGGSPYPGIPVEELFSLLREGHR 667
Query: 1060 LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLD 1096
+ PP CP E++ LM+ CW +P RP+F L LD
Sbjct: 668 MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 704
Score = 64.7 bits (156), Expect = 5e-10
Identities = 66/294 (22%), Positives = 131/294 (44%), Gaps = 34/294 (11%)
Query: 515 KIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEA-RKTEVLLKVM--DAKHKNCMESFLE 571
+ P D L + LG G F ++ R + + + V +K++ +A K+ + E
Sbjct: 421 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 480
Query: 572 AASLMSQVSYRHLVLLHGVC-MAGDSTMVQEFVHLGAIDMYLRKR-------------GH 617
+ +++++ L GVC G ++ E G + +LR R
Sbjct: 481 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSS 540
Query: 618 LVPASWKLQV--VKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVS 675
P S+ + V Q+A + YLE + H +++AR VL+ + +K++D G++
Sbjct: 541 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV------MKIADFGLA 594
Query: 676 PAVLSLEML----TDRIP--WVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISAL 729
V ++ R+P W+APE L + + + ++D W FG +WE+F+ P +
Sbjct: 595 RGVHHIDYYKKTSNGRLPVKWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGI 653
Query: 730 DPAKKLQFYEDRQQLPAPKW--TELALLIQQCMAYEPVQRPSFRAVIRDLNSLI 781
+ + ++ P EL L+++C P QRP+F+ ++ L+ ++
Sbjct: 654 PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 707
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 160 bits (405), Expect = 6e-39
Identities = 116/337 (34%), Positives = 164/337 (48%), Gaps = 58/337 (17%)
Query: 788 LSDPTPGALA-------PRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSV---E 837
LS P LA P D LW F L LG+G FG V E
Sbjct: 438 LSSSGPALLAGLVSLDLPLDPLWE------------FPRDRLVLGKPLGEGCFGQVVRAE 485
Query: 838 LCRYDPLGDNTGALVAVKQLQHSGPDQQ-RDFQREIQILKAL--HSDFIVKYRGVSYGPG 894
DP + + VAVK L+ + D+ D E++++K + H + I+ GV G
Sbjct: 486 AFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN-IINLLGVCTQEG 544
Query: 895 RQSLRLVMEYLPSGCLRDFLQRHR---------------ARLDASRLLLYSSQICKGMEY 939
L +++E G LR+FL+ R L L+ + Q+ +GM+Y
Sbjct: 545 --PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQY 602
Query: 940 LGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESL 999
L SR+C+HRDLAARN+LV + +KIADFGLA+ + DYY G+ P+ W APE+L
Sbjct: 603 LESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH-HIDYYKKTSNGRLPVKWMAPEAL 661
Query: 1000 SDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQR 1059
D +++ QSDVWSFG++L+E+FT + G + L LL EG R
Sbjct: 662 FDRVYTHQSDVWSFGILLWEIFT--------------LGGSPYPGIPVEELFSLLREGHR 707
Query: 1060 LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLD 1096
+ PP CP E++ LM+ CW +P RP+F L LD
Sbjct: 708 MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
Score = 64.7 bits (156), Expect = 5e-10
Identities = 66/294 (22%), Positives = 131/294 (44%), Gaps = 34/294 (11%)
Query: 515 KIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEA-RKTEVLLKVM--DAKHKNCMESFLE 571
+ P D L + LG G F ++ R + + + V +K++ +A K+ + E
Sbjct: 461 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 520
Query: 572 AASLMSQVSYRHLVLLHGVC-MAGDSTMVQEFVHLGAIDMYLRKR-------------GH 617
+ +++++ L GVC G ++ E G + +LR R
Sbjct: 521 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSS 580
Query: 618 LVPASWKLQV--VKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVS 675
P S+ + V Q+A + YLE + H +++AR VL+ + +K++D G++
Sbjct: 581 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV------MKIADFGLA 634
Query: 676 PAVLSLEML----TDRIP--WVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISAL 729
V ++ R+P W+APE L + + + ++D W FG +WE+F+ P +
Sbjct: 635 RGVHHIDYYKKTSNGRLPVKWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGI 693
Query: 730 DPAKKLQFYEDRQQLPAPKW--TELALLIQQCMAYEPVQRPSFRAVIRDLNSLI 781
+ + ++ P EL L+++C P QRP+F+ ++ L+ ++
Sbjct: 694 PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 160 bits (405), Expect = 6e-39
Identities = 116/337 (34%), Positives = 164/337 (48%), Gaps = 58/337 (17%)
Query: 788 LSDPTPGALA-------PRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSV---E 837
LS P LA P D LW F L LG+G FG V E
Sbjct: 438 LSSSGPALLAGLVSLDLPLDPLWE------------FPRDRLVLGKPLGEGCFGQVVRAE 485
Query: 838 LCRYDPLGDNTGALVAVKQLQHSGPDQQ-RDFQREIQILKAL--HSDFIVKYRGVSYGPG 894
DP + + VAVK L+ + D+ D E++++K + H + I+ GV G
Sbjct: 486 AFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN-IINLLGVCTQEG 544
Query: 895 RQSLRLVMEYLPSGCLRDFLQRHR---------------ARLDASRLLLYSSQICKGMEY 939
L +++E G LR+FL+ R L L+ + Q+ +GM+Y
Sbjct: 545 --PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQY 602
Query: 940 LGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESL 999
L SR+C+HRDLAARN+LV + +KIADFGLA+ + DYY G+ P+ W APE+L
Sbjct: 603 LESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH-HIDYYKKTSNGRLPVKWMAPEAL 661
Query: 1000 SDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQR 1059
D +++ QSDVWSFG++L+E+FT + G + L LL EG R
Sbjct: 662 FDRVYTHQSDVWSFGILLWEIFT--------------LGGSPYPGIPVEELFSLLREGHR 707
Query: 1060 LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLD 1096
+ PP CP E++ LM+ CW +P RP+F L LD
Sbjct: 708 MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
Score = 64.7 bits (156), Expect = 5e-10
Identities = 66/294 (22%), Positives = 131/294 (44%), Gaps = 34/294 (11%)
Query: 515 KIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEA-RKTEVLLKVM--DAKHKNCMESFLE 571
+ P D L + LG G F ++ R + + + V +K++ +A K+ + E
Sbjct: 461 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 520
Query: 572 AASLMSQVSYRHLVLLHGVC-MAGDSTMVQEFVHLGAIDMYLRKR-------------GH 617
+ +++++ L GVC G ++ E G + +LR R
Sbjct: 521 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSS 580
Query: 618 LVPASWKLQV--VKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVS 675
P S+ + V Q+A + YLE + H +++AR VL+ + +K++D G++
Sbjct: 581 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV------MKIADFGLA 634
Query: 676 PAVLSLEML----TDRIP--WVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISAL 729
V ++ R+P W+APE L + + + ++D W FG +WE+F+ P +
Sbjct: 635 RGVHHIDYYKKTSNGRLPVKWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGI 693
Query: 730 DPAKKLQFYEDRQQLPAPKW--TELALLIQQCMAYEPVQRPSFRAVIRDLNSLI 781
+ + ++ P EL L+++C P QRP+F+ ++ L+ ++
Sbjct: 694 PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
[Homo sapiens]
Length = 790
Score = 159 bits (402), Expect = 1e-38
Identities = 112/327 (34%), Positives = 163/327 (49%), Gaps = 40/327 (12%)
Query: 795 ALAPRDGLWNGAQLYACQDPTIFEERHLKYIS--------QLGKGNFGSVELCR-YDPLG 845
+L+P +G +G Q + ++P F + + +I +LG+G FG V L ++ L
Sbjct: 469 SLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP 528
Query: 846 DNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYL 905
+ LVAVK L+ + ++DFQRE ++L L IV++ GV GR L +V EY+
Sbjct: 529 EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCT-EGRPLL-MVFEYM 586
Query: 906 PSGCLRDFLQRHR--------------ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLA 951
G L FL+ H L +LL +SQ+ GM YL VHRDLA
Sbjct: 587 RHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA 646
Query: 952 ARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVW 1011
RN LV VKI DFG+++ + DYY V PI W PES+ F+ +SDVW
Sbjct: 647 TRNCLVGQGLVVKIGDFGMSRDI-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVW 705
Query: 1012 SFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVH 1071
SFGVVL+E+FTY + ++ E ++ + +G+ L P ACP EV+
Sbjct: 706 SFGVVLWEIFTY------GKQPWYQLSNTE--------AIDCITQGRELERPRACPPEVY 751
Query: 1072 ELMKLCWAPSPQDRPSFSALGPQLDML 1098
+M+ CW PQ R S + +L L
Sbjct: 752 AIMRGCWQREPQQRHSIKDVHARLQAL 778
Score = 79.0 bits (193), Expect = 2e-14
Identities = 72/285 (25%), Positives = 125/285 (43%), Gaps = 37/285 (12%)
Query: 521 LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVS 580
L+W LG G+F K++ H ++ E K V +K + ++ + F A L++ +
Sbjct: 506 LKWE--LGEGAFGKVFLAECHNLLP-EQDKMLVAVKALKEASESARQDFQREAELLTMLQ 562
Query: 581 YRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLRKRG----------HLVPA----SWKL 625
++H+V GVC G MV E++ G ++ +LR G + P L
Sbjct: 563 HQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLL 622
Query: 626 QVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLE--- 682
V Q+A + YL H +++ R L+ G +K+ D G+S + S +
Sbjct: 623 AVASQVAAGMVYLAGLHFVHRDLATRNCLV------GQGLVVKIGDFGMSRDIYSTDYYR 676
Query: 683 -----MLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQF 737
ML R W+ PE + + + E+D W FG +WE+F+ P L + +
Sbjct: 677 VGGRTMLPIR--WMPPESILYRK-FTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC 733
Query: 738 YEDRQQLPAPKW--TELALLIQQCMAYEPVQRPSFRAVIRDLNSL 780
++L P+ E+ +++ C EP QR S + V L +L
Sbjct: 734 ITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 778
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 159 bits (402), Expect = 1e-38
Identities = 112/327 (34%), Positives = 163/327 (49%), Gaps = 40/327 (12%)
Query: 795 ALAPRDGLWNGAQLYACQDPTIFEERHLKYIS--------QLGKGNFGSVELCR-YDPLG 845
+L+P +G +G Q + ++P F + + +I +LG+G FG V L ++ L
Sbjct: 475 SLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP 534
Query: 846 DNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYL 905
+ LVAVK L+ + ++DFQRE ++L L IV++ GV GR L +V EY+
Sbjct: 535 EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCT-EGRPLL-MVFEYM 592
Query: 906 PSGCLRDFLQRHR--------------ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLA 951
G L FL+ H L +LL +SQ+ GM YL VHRDLA
Sbjct: 593 RHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA 652
Query: 952 ARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVW 1011
RN LV VKI DFG+++ + DYY V PI W PES+ F+ +SDVW
Sbjct: 653 TRNCLVGQGLVVKIGDFGMSRDI-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVW 711
Query: 1012 SFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVH 1071
SFGVVL+E+FTY + ++ E ++ + +G+ L P ACP EV+
Sbjct: 712 SFGVVLWEIFTY------GKQPWYQLSNTE--------AIDCITQGRELERPRACPPEVY 757
Query: 1072 ELMKLCWAPSPQDRPSFSALGPQLDML 1098
+M+ CW PQ R S + +L L
Sbjct: 758 AIMRGCWQREPQQRHSIKDVHARLQAL 784
Score = 79.0 bits (193), Expect = 2e-14
Identities = 72/285 (25%), Positives = 125/285 (43%), Gaps = 37/285 (12%)
Query: 521 LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVS 580
L+W LG G+F K++ H ++ E K V +K + ++ + F A L++ +
Sbjct: 512 LKWE--LGEGAFGKVFLAECHNLLP-EQDKMLVAVKALKEASESARQDFQREAELLTMLQ 568
Query: 581 YRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLRKRG----------HLVPA----SWKL 625
++H+V GVC G MV E++ G ++ +LR G + P L
Sbjct: 569 HQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLL 628
Query: 626 QVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLE--- 682
V Q+A + YL H +++ R L+ G +K+ D G+S + S +
Sbjct: 629 AVASQVAAGMVYLAGLHFVHRDLATRNCLV------GQGLVVKIGDFGMSRDIYSTDYYR 682
Query: 683 -----MLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQF 737
ML R W+ PE + + + E+D W FG +WE+F+ P L + +
Sbjct: 683 VGGRTMLPIR--WMPPESILYRK-FTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC 739
Query: 738 YEDRQQLPAPKW--TELALLIQQCMAYEPVQRPSFRAVIRDLNSL 780
++L P+ E+ +++ C EP QR S + V L +L
Sbjct: 740 ITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 784
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
[Homo sapiens]
Length = 760
Score = 159 bits (402), Expect = 1e-38
Identities = 112/327 (34%), Positives = 163/327 (49%), Gaps = 40/327 (12%)
Query: 795 ALAPRDGLWNGAQLYACQDPTIFEERHLKYIS--------QLGKGNFGSVELCR-YDPLG 845
+L+P +G +G Q + ++P F + + +I +LG+G FG V L ++ L
Sbjct: 439 SLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP 498
Query: 846 DNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYL 905
+ LVAVK L+ + ++DFQRE ++L L IV++ GV GR L +V EY+
Sbjct: 499 EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCT-EGRPLL-MVFEYM 556
Query: 906 PSGCLRDFLQRHR--------------ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLA 951
G L FL+ H L +LL +SQ+ GM YL VHRDLA
Sbjct: 557 RHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA 616
Query: 952 ARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVW 1011
RN LV VKI DFG+++ + DYY V PI W PES+ F+ +SDVW
Sbjct: 617 TRNCLVGQGLVVKIGDFGMSRDI-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVW 675
Query: 1012 SFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVH 1071
SFGVVL+E+FTY + ++ E ++ + +G+ L P ACP EV+
Sbjct: 676 SFGVVLWEIFTY------GKQPWYQLSNTE--------AIDCITQGRELERPRACPPEVY 721
Query: 1072 ELMKLCWAPSPQDRPSFSALGPQLDML 1098
+M+ CW PQ R S + +L L
Sbjct: 722 AIMRGCWQREPQQRHSIKDVHARLQAL 748
Score = 79.0 bits (193), Expect = 2e-14
Identities = 72/285 (25%), Positives = 125/285 (43%), Gaps = 37/285 (12%)
Query: 521 LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVS 580
L+W LG G+F K++ H ++ E K V +K + ++ + F A L++ +
Sbjct: 476 LKWE--LGEGAFGKVFLAECHNLLP-EQDKMLVAVKALKEASESARQDFQREAELLTMLQ 532
Query: 581 YRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLRKRG----------HLVPA----SWKL 625
++H+V GVC G MV E++ G ++ +LR G + P L
Sbjct: 533 HQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLL 592
Query: 626 QVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLE--- 682
V Q+A + YL H +++ R L+ G +K+ D G+S + S +
Sbjct: 593 AVASQVAAGMVYLAGLHFVHRDLATRNCLV------GQGLVVKIGDFGMSRDIYSTDYYR 646
Query: 683 -----MLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQF 737
ML R W+ PE + + + E+D W FG +WE+F+ P L + +
Sbjct: 647 VGGRTMLPIR--WMPPESILYRK-FTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC 703
Query: 738 YEDRQQLPAPKW--TELALLIQQCMAYEPVQRPSFRAVIRDLNSL 780
++L P+ E+ +++ C EP QR S + V L +L
Sbjct: 704 ITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 748
>gi|18250298 src-related kinase lacking C-terminal regulatory tyrosine
and N-terminal myristylation sites [Homo sapiens]
Length = 488
Score = 159 bits (401), Expect = 2e-38
Identities = 104/283 (36%), Positives = 153/283 (54%), Gaps = 27/283 (9%)
Query: 816 IFEERHLKYI--SQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQ 873
++E H ++ +LG+G FG V ++ L G+L ++ S + D +EIQ
Sbjct: 222 VWERPHSEFALGRKLGEGYFGEV----WEGLW--LGSLPVAIKVIKSANMKLTDLAKEIQ 275
Query: 874 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR-LDASRLLLYSSQ 932
LK L + +++ V G + + +V E + G L+ FL R L LL ++ Q
Sbjct: 276 TLKGLRHERLIRLHAVC--SGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333
Query: 933 ICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIF 992
+ +GM YL +R VHRDLAARN+LV+ K+ADFGLA+L L D Y + P+
Sbjct: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARL--LKDDIYSPSSSSKIPVK 391
Query: 993 WYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLE 1052
W APE+ + +FS++SDVWSFGV+L+E+FTY C + L+
Sbjct: 392 WTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQ--------------CPYEGMTNHETLQ 437
Query: 1053 LLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQL 1095
+ G RLP P ACPAEV+ LM CW SP++RPSF+ L +L
Sbjct: 438 QIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
Score = 68.9 bits (167), Expect = 2e-11
Identities = 74/292 (25%), Positives = 126/292 (43%), Gaps = 26/292 (8%)
Query: 499 LVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM 558
L+QP + + + P LG G F +++ G V +KV+
Sbjct: 208 LLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLW-------LGSLPVAIKVI 260
Query: 559 DAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYL-RKRG 616
+ + + E +L + + L+ LH VC G+ +V E + G + +L G
Sbjct: 261 KSANMKLTDLAKEIQTLKG-LRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEG 319
Query: 617 HLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVL----LAREGADGSPPFIKLSDP 672
+ L Q+A ++YLE++ + H +++AR VL LA + AD + L D
Sbjct: 320 RALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARL-LKDD 378
Query: 673 GVSPAVLSLEMLTDRIP--WVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALD 730
SP+ S +IP W APE + S ++D W FG + EVF+ P +
Sbjct: 379 IYSPSSSS------KIPVKWTAPEAANY-RVFSQKSDVWSFGVLLHEVFTYGQCPYEGMT 431
Query: 731 PAKKLQFYEDRQQLPAPKW--TELALLIQQCMAYEPVQRPSFRAVIRDLNSL 780
+ LQ +LP P E+ +L+ +C P +RPSF + L+++
Sbjct: 432 NHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAI 483
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 157 bits (396), Expect = 7e-38
Identities = 103/304 (33%), Positives = 160/304 (52%), Gaps = 52/304 (17%)
Query: 813 DPTIF---EERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQL-QHSGPDQQRDF 868
DPTI+ + +K+ +G+GNFG V R G A A+K++ +++ D RDF
Sbjct: 812 DPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDA--AIKRMKEYASKDDHRDF 869
Query: 869 QREIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHR--------- 918
E+++L L H I+ G G L L +EY P G L DFL++ R
Sbjct: 870 AGELEVLCKLGHHPNIINLLGACEHRGY--LYLAIEYAPHGNLLDFLRKSRVLETDPAFA 927
Query: 919 ------ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAK 972
+ L + +LL +++ + +GM+YL ++ +HRDLAARNILV KIADFGL++
Sbjct: 928 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR 987
Query: 973 LLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFT-----YCDKS 1027
++ YV + G+ P+ W A ESL+ ++++ SDVWS+GV+L+E+ + YC +
Sbjct: 988 ----GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMT 1043
Query: 1028 CSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 1087
C+ L E L +G RL P C EV++LM+ CW P +RPS
Sbjct: 1044 CA-------------------ELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPS 1084
Query: 1088 FSAL 1091
F+ +
Sbjct: 1085 FAQI 1088
Score = 52.0 bits (123), Expect = 3e-06
Identities = 41/162 (25%), Positives = 76/162 (46%), Gaps = 12/162 (7%)
Query: 625 LQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAV-LSLEM 683
L +A ++YL K H +++AR +L+ G K++D G+S + ++
Sbjct: 942 LHFAADVARGMDYLSQKQFIHRDLAARNILV------GENYVAKIADFGLSRGQEVYVKK 995
Query: 684 LTDRIP--WVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDR 741
R+P W+A E L + + +D W +G +WE+ S P + A+ +
Sbjct: 996 TMGRLPVRWMAIESLNYS-VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG 1054
Query: 742 QQLPAPKWT--ELALLIQQCMAYEPVQRPSFRAVIRDLNSLI 781
+L P E+ L++QC +P +RPSF ++ LN ++
Sbjct: 1055 YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 155 bits (393), Expect = 2e-37
Identities = 105/291 (36%), Positives = 152/291 (52%), Gaps = 35/291 (12%)
Query: 811 CQDPTIF-----------EERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH 859
C PT++ E + +LG G +G V Y + VAVK L+
Sbjct: 251 CNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV----YVGVWKKYSLTVAVKTLKE 306
Query: 860 SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR-HR 918
+ + +F +E ++K + +V+ GV +V EY+P G L D+L+ +R
Sbjct: 307 DTMEVE-EFLKEAAVMKEIKHPNLVQLLGVC--TLEPPFYIVTEYMPYGNLLDYLRECNR 363
Query: 919 ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDK 978
+ A LL ++QI MEYL + +HRDLAARN LV VK+ADFGL++L +
Sbjct: 364 EEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL--MTG 421
Query: 979 DYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMM 1038
D Y + PI W APESL+ N FS +SDVW+FGV+L+E+ TY S P +
Sbjct: 422 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY-GMSPYPGID----- 475
Query: 1039 GCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFS 1089
L ++ +LLE+G R+ P CP +V+ELM+ CW SP DRPSF+
Sbjct: 476 --------LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 518
Score = 80.9 bits (198), Expect = 6e-15
Identities = 69/248 (27%), Positives = 120/248 (48%), Gaps = 19/248 (7%)
Query: 534 KIYRGCRHEVVDGEARKTEVLLKVMDAKHKNC-MESFLEAASLMSQVSYRHLVLLHGVC- 591
K+ G EV G +K + + V K +E FL+ A++M ++ + +LV L GVC
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337
Query: 592 MAGDSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSA 650
+ +V E++ G + YLR+ V A L + Q++ A+ YLE K H +++A
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397
Query: 651 RKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR------IPWVAPECLREAQTLSL 704
R L+ G +K++D G+S +++ + T I W APE L T S+
Sbjct: 398 RNCLV------GENHVVKVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAY-NTFSI 449
Query: 705 EADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKW--TELALLIQQCMAY 762
++D W FG +WE+ + P +D ++ E ++ P+ ++ L++ C +
Sbjct: 450 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 509
Query: 763 EPVQRPSF 770
P RPSF
Sbjct: 510 SPADRPSF 517
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 155 bits (393), Expect = 2e-37
Identities = 105/291 (36%), Positives = 152/291 (52%), Gaps = 35/291 (12%)
Query: 811 CQDPTIF-----------EERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH 859
C PT++ E + +LG G +G V Y + VAVK L+
Sbjct: 266 CNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV----YVGVWKKYSLTVAVKTLKE 321
Query: 860 SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR-HR 918
+ + +F +E ++K + +V+ GV +V EY+P G L D+L+ +R
Sbjct: 322 DTMEVE-EFLKEAAVMKEIKHPNLVQLLGVC--TLEPPFYIVTEYMPYGNLLDYLRECNR 378
Query: 919 ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDK 978
+ A LL ++QI MEYL + +HRDLAARN LV VK+ADFGL++L +
Sbjct: 379 EEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL--MTG 436
Query: 979 DYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMM 1038
D Y + PI W APESL+ N FS +SDVW+FGV+L+E+ TY S P +
Sbjct: 437 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY-GMSPYPGID----- 490
Query: 1039 GCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFS 1089
L ++ +LLE+G R+ P CP +V+ELM+ CW SP DRPSF+
Sbjct: 491 --------LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 533
Score = 80.9 bits (198), Expect = 6e-15
Identities = 69/248 (27%), Positives = 120/248 (48%), Gaps = 19/248 (7%)
Query: 534 KIYRGCRHEVVDGEARKTEVLLKVMDAKHKNC-MESFLEAASLMSQVSYRHLVLLHGVC- 591
K+ G EV G +K + + V K +E FL+ A++M ++ + +LV L GVC
Sbjct: 293 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 352
Query: 592 MAGDSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSA 650
+ +V E++ G + YLR+ V A L + Q++ A+ YLE K H +++A
Sbjct: 353 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412
Query: 651 RKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR------IPWVAPECLREAQTLSL 704
R L+ G +K++D G+S +++ + T I W APE L T S+
Sbjct: 413 RNCLV------GENHVVKVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAY-NTFSI 464
Query: 705 EADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKW--TELALLIQQCMAY 762
++D W FG +WE+ + P +D ++ E ++ P+ ++ L++ C +
Sbjct: 465 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 524
Query: 763 EPVQRPSF 770
P RPSF
Sbjct: 525 SPADRPSF 532
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 155 bits (393), Expect = 2e-37
Identities = 105/291 (36%), Positives = 152/291 (52%), Gaps = 35/291 (12%)
Query: 811 CQDPTIF-----------EERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH 859
C PT++ E + +LG G +G V Y + VAVK L+
Sbjct: 245 CNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV----YVGVWKKYSLTVAVKTLKE 300
Query: 860 SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR-HR 918
+ + +F +E ++K + +V+ GV +V EY+P G L D+L+ +R
Sbjct: 301 DTMEVE-EFLKEAAVMKEIKHPNLVQLLGVC--TLEPPFYIVTEYMPYGNLLDYLRECNR 357
Query: 919 ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDK 978
+ A LL ++QI MEYL + +HRDLAARN LV VK+ADFGL++L +
Sbjct: 358 EEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL--MTG 415
Query: 979 DYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMM 1038
D Y + PI W APESL+ N FS +SDVW+FGV+L+E+ TY S P +
Sbjct: 416 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY-GMSPYPGID----- 469
Query: 1039 GCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFS 1089
L ++ +LLE+G R+ P CP +V+ELM+ CW SP DRPSF+
Sbjct: 470 --------LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 512
Score = 80.9 bits (198), Expect = 6e-15
Identities = 69/248 (27%), Positives = 120/248 (48%), Gaps = 19/248 (7%)
Query: 534 KIYRGCRHEVVDGEARKTEVLLKVMDAKHKNC-MESFLEAASLMSQVSYRHLVLLHGVC- 591
K+ G EV G +K + + V K +E FL+ A++M ++ + +LV L GVC
Sbjct: 272 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 331
Query: 592 MAGDSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSA 650
+ +V E++ G + YLR+ V A L + Q++ A+ YLE K H +++A
Sbjct: 332 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 391
Query: 651 RKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR------IPWVAPECLREAQTLSL 704
R L+ G +K++D G+S +++ + T I W APE L T S+
Sbjct: 392 RNCLV------GENHVVKVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAY-NTFSI 443
Query: 705 EADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKW--TELALLIQQCMAY 762
++D W FG +WE+ + P +D ++ E ++ P+ ++ L++ C +
Sbjct: 444 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 503
Query: 763 EPVQRPSF 770
P RPSF
Sbjct: 504 SPADRPSF 511
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 155 bits (393), Expect = 2e-37
Identities = 105/291 (36%), Positives = 152/291 (52%), Gaps = 35/291 (12%)
Query: 811 CQDPTIF-----------EERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH 859
C PT++ E + +LG G +G V Y + VAVK L+
Sbjct: 251 CNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV----YVGVWKKYSLTVAVKTLKE 306
Query: 860 SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR-HR 918
+ + +F +E ++K + +V+ GV +V EY+P G L D+L+ +R
Sbjct: 307 DTMEVE-EFLKEAAVMKEIKHPNLVQLLGVC--TLEPPFYIVTEYMPYGNLLDYLRECNR 363
Query: 919 ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDK 978
+ A LL ++QI MEYL + +HRDLAARN LV VK+ADFGL++L +
Sbjct: 364 EEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL--MTG 421
Query: 979 DYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMM 1038
D Y + PI W APESL+ N FS +SDVW+FGV+L+E+ TY S P +
Sbjct: 422 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY-GMSPYPGID----- 475
Query: 1039 GCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFS 1089
L ++ +LLE+G R+ P CP +V+ELM+ CW SP DRPSF+
Sbjct: 476 --------LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 518
Score = 80.9 bits (198), Expect = 6e-15
Identities = 69/248 (27%), Positives = 120/248 (48%), Gaps = 19/248 (7%)
Query: 534 KIYRGCRHEVVDGEARKTEVLLKVMDAKHKNC-MESFLEAASLMSQVSYRHLVLLHGVC- 591
K+ G EV G +K + + V K +E FL+ A++M ++ + +LV L GVC
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337
Query: 592 MAGDSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSA 650
+ +V E++ G + YLR+ V A L + Q++ A+ YLE K H +++A
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397
Query: 651 RKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR------IPWVAPECLREAQTLSL 704
R L+ G +K++D G+S +++ + T I W APE L T S+
Sbjct: 398 RNCLV------GENHVVKVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAY-NTFSI 449
Query: 705 EADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKW--TELALLIQQCMAY 762
++D W FG +WE+ + P +D ++ E ++ P+ ++ L++ C +
Sbjct: 450 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 509
Query: 763 EPVQRPSF 770
P RPSF
Sbjct: 510 SPADRPSF 517
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 155 bits (393), Expect = 2e-37
Identities = 105/291 (36%), Positives = 152/291 (52%), Gaps = 35/291 (12%)
Query: 811 CQDPTIF-----------EERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH 859
C PT++ E + +LG G +G V Y + VAVK L+
Sbjct: 230 CNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV----YVGVWKKYSLTVAVKTLKE 285
Query: 860 SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR-HR 918
+ + +F +E ++K + +V+ GV +V EY+P G L D+L+ +R
Sbjct: 286 DTMEVE-EFLKEAAVMKEIKHPNLVQLLGVC--TLEPPFYIVTEYMPYGNLLDYLRECNR 342
Query: 919 ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDK 978
+ A LL ++QI MEYL + +HRDLAARN LV VK+ADFGL++L +
Sbjct: 343 EEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL--MTG 400
Query: 979 DYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMM 1038
D Y + PI W APESL+ N FS +SDVW+FGV+L+E+ TY S P +
Sbjct: 401 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY-GMSPYPGID----- 454
Query: 1039 GCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFS 1089
L ++ +LLE+G R+ P CP +V+ELM+ CW SP DRPSF+
Sbjct: 455 --------LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 497
Score = 80.9 bits (198), Expect = 6e-15
Identities = 69/248 (27%), Positives = 120/248 (48%), Gaps = 19/248 (7%)
Query: 534 KIYRGCRHEVVDGEARKTEVLLKVMDAKHKNC-MESFLEAASLMSQVSYRHLVLLHGVC- 591
K+ G EV G +K + + V K +E FL+ A++M ++ + +LV L GVC
Sbjct: 257 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 316
Query: 592 MAGDSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSA 650
+ +V E++ G + YLR+ V A L + Q++ A+ YLE K H +++A
Sbjct: 317 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 376
Query: 651 RKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR------IPWVAPECLREAQTLSL 704
R L+ G +K++D G+S +++ + T I W APE L T S+
Sbjct: 377 RNCLV------GENHVVKVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAY-NTFSI 428
Query: 705 EADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKW--TELALLIQQCMAY 762
++D W FG +WE+ + P +D ++ E ++ P+ ++ L++ C +
Sbjct: 429 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 488
Query: 763 EPVQRPSF 770
P RPSF
Sbjct: 489 SPADRPSF 496
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 155 bits (392), Expect = 2e-37
Identities = 99/297 (33%), Positives = 162/297 (54%), Gaps = 28/297 (9%)
Query: 809 YACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTG-ALVAVKQLQHSGPDQQRD 867
++ D F L+ I+ LGK FG V L + L + LV VK LQ QQ D
Sbjct: 783 HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 842
Query: 868 FQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR------- 920
F+RE+++ L+ +V+ G+ + +V+EY+ G L+ FL+ +++
Sbjct: 843 FRRELEMFGKLNHANVVRLLGLCREA--EPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 900
Query: 921 -LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKD 979
L + + +Q+ GME+L + R VH+DLAARN LV ++ VK++ GL+K + + +
Sbjct: 901 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV-YNSE 959
Query: 980 YYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMG 1039
YY R+ P+ W +PE++ + FS +SDVW+FGV+++E+FT+ + A+
Sbjct: 960 YYHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADD----- 1013
Query: 1040 CERDVPALCRLLELLEEGQ-RLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQL 1095
+L L+ G+ RLP P CP++++ LM+ CWA SP+DRPSFS + L
Sbjct: 1014 ---------EVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
Score = 85.5 bits (210), Expect = 3e-16
Identities = 70/274 (25%), Positives = 127/274 (46%), Gaps = 25/274 (9%)
Query: 517 PADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLM 576
P SL+ LG F +++ + +G A +T VL+K + +K + F +
Sbjct: 792 PRSSLQPITTLGKSEFGEVFLAKAQGLEEGVA-ETLVLVKSLQSKDEQQQLDFRRELEMF 850
Query: 577 SQVSYRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLR--------KRGHLVPASWKLQV 627
++++ ++V L G+C + MV E+V LG + +LR + + K+ +
Sbjct: 851 GKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVAL 910
Query: 628 VKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR 687
Q+A + +L + H +++AR L++ + +K+S G+S V + E R
Sbjct: 911 CTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQ------VKVSALGLSKDVYNSEYYHFR 964
Query: 688 -----IPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISA-LDPAKKLQFYEDR 741
+ W++PE + E S ++D W FG +WEVF+ MP D +
Sbjct: 965 QAWVPLRWMSPEAILEGD-FSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK 1023
Query: 742 QQLPAPKW--TELALLIQQCMAYEPVQRPSFRAV 773
+LP P+ ++L L+Q+C A P RPSF +
Sbjct: 1024 ARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1057
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 155 bits (392), Expect = 2e-37
Identities = 99/297 (33%), Positives = 162/297 (54%), Gaps = 28/297 (9%)
Query: 809 YACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTG-ALVAVKQLQHSGPDQQRD 867
++ D F L+ I+ LGK FG V L + L + LV VK LQ QQ D
Sbjct: 727 HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 786
Query: 868 FQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR------- 920
F+RE+++ L+ +V+ G+ + +V+EY+ G L+ FL+ +++
Sbjct: 787 FRRELEMFGKLNHANVVRLLGLCREA--EPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 844
Query: 921 -LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKD 979
L + + +Q+ GME+L + R VH+DLAARN LV ++ VK++ GL+K + + +
Sbjct: 845 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV-YNSE 903
Query: 980 YYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMG 1039
YY R+ P+ W +PE++ + FS +SDVW+FGV+++E+FT+ + A+
Sbjct: 904 YYHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADD----- 957
Query: 1040 CERDVPALCRLLELLEEGQ-RLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQL 1095
+L L+ G+ RLP P CP++++ LM+ CWA SP+DRPSFS + L
Sbjct: 958 ---------EVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
Score = 85.5 bits (210), Expect = 3e-16
Identities = 70/274 (25%), Positives = 127/274 (46%), Gaps = 25/274 (9%)
Query: 517 PADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLM 576
P SL+ LG F +++ + +G A +T VL+K + +K + F +
Sbjct: 736 PRSSLQPITTLGKSEFGEVFLAKAQGLEEGVA-ETLVLVKSLQSKDEQQQLDFRRELEMF 794
Query: 577 SQVSYRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLR--------KRGHLVPASWKLQV 627
++++ ++V L G+C + MV E+V LG + +LR + + K+ +
Sbjct: 795 GKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVAL 854
Query: 628 VKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDR 687
Q+A + +L + H +++AR L++ + +K+S G+S V + E R
Sbjct: 855 CTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQ------VKVSALGLSKDVYNSEYYHFR 908
Query: 688 -----IPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISA-LDPAKKLQFYEDR 741
+ W++PE + E S ++D W FG +WEVF+ MP D +
Sbjct: 909 QAWVPLRWMSPEAILEGD-FSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK 967
Query: 742 QQLPAPKW--TELALLIQQCMAYEPVQRPSFRAV 773
+LP P+ ++L L+Q+C A P RPSF +
Sbjct: 968 ARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1001
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,609,318
Number of Sequences: 37866
Number of extensions: 2322949
Number of successful extensions: 8061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 583
Number of HSP's successfully gapped in prelim test: 201
Number of HSP's that attempted gapping in prelim test: 5332
Number of HSP's gapped (non-prelim): 1444
length of query: 1124
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1011
effective length of database: 13,968,660
effective search space: 14122315260
effective search space used: 14122315260
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.