Search of human proteins with 4557463

Search of human proteins with 4557463

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
precursor [Homo sapiens]
         (493 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   996   0.0  
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   479   e-135
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   423   e-118
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   350   2e-96
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   308   1e-83
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     306   3e-83
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   301   9e-82
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   298   6e-81
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    290   2e-78
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   276   2e-74
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   276   2e-74
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   258   1e-68
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   251   8e-67
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   245   6e-65
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   230   2e-60
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   221   1e-57
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   211   2e-54
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   166   6e-41
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   164   2e-40
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   151   1e-36
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              148   1e-35
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   125   1e-28
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   110   4e-24
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              107   2e-23
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   106   4e-23
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...    65   1e-10
gi|4504023 glycine receptor, beta [Homo sapiens]                       62   9e-10
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...    59   1e-08
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...    59   1e-08
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ...    59   1e-08

>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  996 bits (2574), Expect = 0.0
 Identities = 493/493 (100%), Positives = 493/493 (100%)

Query: 1   MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNL 60
           MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNL
Sbjct: 1   MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNL 60

Query: 61  ISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF 120
           ISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF
Sbjct: 61  ISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF 120

Query: 121 GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF 180
           GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF
Sbjct: 121 GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF 180

Query: 181 AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP 240
           AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP
Sbjct: 181 AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP 240

Query: 241 LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS 300
           LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS
Sbjct: 241 LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS 300

Query: 301 VPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPP 360
           VPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPP
Sbjct: 301 VPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPP 360

Query: 361 EAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV 420
           EAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV
Sbjct: 361 EAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV 420

Query: 421 RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFN 480
           RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFN
Sbjct: 421 RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFN 480

Query: 481 RVPDLPYAPCIQP 493
           RVPDLPYAPCIQP
Sbjct: 481 RVPDLPYAPCIQP 493


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  479 bits (1234), Expect = e-135
 Identities = 258/503 (51%), Positives = 329/503 (65%), Gaps = 20/503 (3%)

Query: 3   RAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLIS 62
           + PL +LLLL +     G+N+E RL   L  NYDP  RP     D V +SLK+TLTNLIS
Sbjct: 5   QGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLIS 64

Query: 63  LNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGV 122
           LNE+EE LTT+VWI + W DYRL +   D+ G+  LRVPS +VW P+IVLENN+DG F V
Sbjct: 65  LNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEV 124

Query: 123 AYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAV 182
           A   NVLV   G + WLPPAI+RS C++ VTYFPFDWQNCSLIF+SQTY+  E++   + 
Sbjct: 125 ALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLS- 183

Query: 183 DNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLF 242
             DG+TI  I ID EA+TENGEWAI   P  +           G   V++ L+I+RKPLF
Sbjct: 184 QEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLF 243

Query: 243 YVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVP 302
           YVINII PCVLIS + +L +FLPA+AGGQKCTV+INVLLAQTVFLFL+A+K+PETS +VP
Sbjct: 244 YVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVP 303

Query: 303 LLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEA 362
           L+ ++L F++VV  LIV+N V+VLNVS R+P TH+M+  +R V L LLP+LL     P A
Sbjct: 304 LISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLA 363

Query: 363 PRAA----SPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAA---------- 408
           P A     S  +  SS   +   EE+ L  PRSEL+F+ Q  RQG   AA          
Sbjct: 364 PAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQ-QWQRQGLVAAALEKLEKGPEL 422

Query: 409 ----FCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALV 464
               FC SL  AAP ++ CV+A N +A +   Q        +W  +G  LD +CF A L 
Sbjct: 423 GLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLS 482

Query: 465 LFSVGSSLIFLGAYFNRVPDLPY 487
           LF  G++ IFL A++NRVP LP+
Sbjct: 483 LFICGTAGIFLMAHYNRVPALPF 505


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  423 bits (1087), Expect = e-118
 Identities = 229/497 (46%), Positives = 313/497 (62%), Gaps = 17/497 (3%)

Query: 6   LGVLLLLGLLGRGVGKNEELRLYHHLFNN--YDPGSRPVREPEDTVTISLKVTLTNLISL 63
           LG+L  L + G   G NEE RL  HLF    Y+   RPV   E++V ++L +TL+NLISL
Sbjct: 8   LGLLAALAVCGSW-GLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISL 66

Query: 64  NEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVA 123
            E EETLTT+VWI   W D RL ++ ++FG I  LR+P ++VWLPEIVLENN DG F ++
Sbjct: 67  KEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQIS 126

Query: 124 YDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF--- 180
           Y  NVLVY  G V WLPPAI+RS C + VTYFPFDWQNCSL F S  Y A+E+  +    
Sbjct: 127 YSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQD 186

Query: 181 AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP 240
           A +N    +  I ID E +TENGEW I   P  +        D P   D+ + LIIRRKP
Sbjct: 187 AKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKP 246

Query: 241 LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS 300
           LFY+INI+VPCVLIS +V L ++LPA + G+K +V+I+VLLAQ+VFL LI++++P TS++
Sbjct: 247 LFYIINILVPCVLISFMVNLVFYLPADS-GEKTSVAISVLLAQSVFLLLISKRLPATSMA 305

Query: 301 VPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLG-SPPP 359
           +PL+G+FL+F MV+ T++V+ CVIVLN+  RTP+TH +S  ++ + LE LP LL  S P 
Sbjct: 306 IPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPA 365

Query: 360 PEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTW---------TAAFC 410
            + P   +  RR+SS+G + +AEE  L K RS+L+FE Q  R G            A+  
Sbjct: 366 EDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSE 425

Query: 411 QSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGS 470
           Q+      E++  VD  NF+    RDQ    EE   W R+   +D +C +    +  VG+
Sbjct: 426 QAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGT 485

Query: 471 SLIFLGAYFNRVPDLPY 487
           + IFL   +N+ P  P+
Sbjct: 486 AWIFLQGVYNQPPPQPF 502


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  350 bits (897), Expect = 2e-96
 Identities = 196/500 (39%), Positives = 292/500 (58%), Gaps = 19/500 (3%)

Query: 5   PLGVLLLLGLLGRGV-----GKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTN 59
           P  +L+LLG LG  +     G   E RL   LF+ YD   RP RE  D V +S+ + L  
Sbjct: 3   PGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQ 62

Query: 60  LISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQ 119
           LISLNEK+E ++T V++ ++W DYRL++   +  GI++LR+ +E VWLP++VL NN DG 
Sbjct: 63  LISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGN 122

Query: 120 FGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFT 179
           F VA D +V+V   GSV W PP IYRS C+++VTYFPFDWQNC+++F S +Y++ EV   
Sbjct: 123 FDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQ 182

Query: 180 FAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHG---GATDGPGETDVIYSLII 236
             +  DG+   +I I    + ENG+W I   P  + +  G   G  +G  + +VI+ LII
Sbjct: 183 TGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQ-EVIFYLII 241

Query: 237 RRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPE 296
           RRKPLFY++N+I PC+LI+ L +  ++LP  A G+K  +SI  LL  TVFL L+A K+PE
Sbjct: 242 RRKPLFYLVNVIAPCILITLLAIFVFYLPPDA-GEKMGLSIFALLTLTVFLLLLADKVPE 300

Query: 297 TSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLG- 355
           TSLSVP++ ++L+F MV+ T  V+  V+VLN+  R+P TH M   +R + +  LP  L  
Sbjct: 301 TSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRL 360

Query: 356 SPPPPEAPRAASPPRRAS-SVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSL- 413
             P PE      PP  +S   G     +E  ++KP S+ +F      Q   +A   +   
Sbjct: 361 KRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFI 420

Query: 414 ------GAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFS 467
                  A  PE+R  V +++++A   ++QE       DW  +   +D +  W  ++  S
Sbjct: 421 DGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTS 480

Query: 468 VGSSLIFLGAYFNRVPDLPY 487
           VG+ +IFL A ++  P  P+
Sbjct: 481 VGTLVIFLDATYHLPPPDPF 500


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  308 bits (788), Expect = 1e-83
 Identities = 189/500 (37%), Positives = 277/500 (55%), Gaps = 38/500 (7%)

Query: 1   MAR--APLGVLLLLGLLG--RGV-GKNEELRLYHHLFN--NYDPGSRPVREPEDTVTISL 53
           MAR   P+ +LL  GLL    GV G + E RL  HL +   Y+   RP     + VT+ L
Sbjct: 1   MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL 60

Query: 54  KVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLE 113
            V+L  LIS++E+E+ +TT+VW+  +W+DYRL +  ++F  ++ +R+PS+ +WLP++VL 
Sbjct: 61  MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY 120

Query: 114 NNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNA 173
           NN DG + V++ +N +V   GS+ WLPPAIY+S C +EV +FPFD QNC++ FRS TY+ 
Sbjct: 121 NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR 180

Query: 174 EEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYS 233
            E++     +     +  +D     +T +GEW I   PG  RR+     D     D+ Y 
Sbjct: 181 TEIDLVLKSE-----VASLD----DFTPSGEWDIVALPG--RRNEN--PDDSTYVDITYD 227

Query: 234 LIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQK 293
            IIRRKPLFY IN+I+PCVLI+ L +L ++LP+   G+K T+ I+VLLA TVFL LI++ 
Sbjct: 228 FIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC-GEKMTLCISVLLALTVFLLLISKI 286

Query: 294 IPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRL 353
           +P TSL VPL+G++L+F MV+ T  ++  V VLNV  R+PTTH M+P ++ V LE LP L
Sbjct: 287 VPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPAL 346

Query: 354 LGSPPP-----PEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAA 408
           L    P      +  R     R     G L   E        S   F  +   QG   A 
Sbjct: 347 LFMQQPRHHCARQRLRLRRRQREREGAGALFFRE---APGADSCTCFVNRASVQGLAGAF 403

Query: 409 FCQSLGAAAP---------EVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICF 459
             +    A P          +R  VD V F+A+  R ++       DW  +   +D +  
Sbjct: 404 GAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFL 463

Query: 460 WAALVLFSVGSSLIFLGAYF 479
           W  + +   G+  +FL   F
Sbjct: 464 WIFVFVCVFGTIGMFLQPLF 483


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  306 bits (784), Expect = 3e-83
 Identities = 185/512 (36%), Positives = 278/512 (54%), Gaps = 42/512 (8%)

Query: 1   MARAPLGVLL-LLGLLGRGVGK--NEELRLYHHLFNN--YDPGSRPVREPEDTVTISLKV 55
           M RAP  VL  L+ L GRG  +  N E +L   L N   Y+   RP       ++I L++
Sbjct: 1   MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 60

Query: 56  TLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENN 115
           +L  LIS+NE+E+ +TT+VW+  +W DYRL ++   + G+  LR+P++ +WLP+IVL NN
Sbjct: 61  SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 120

Query: 116 IDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEE 175
            DG + V+   N++V   GSV WLPPAIY+S C +EV YFPFD QNC+L FRS TY+  E
Sbjct: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180

Query: 176 VEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLI 235
           ++                   + +T +GEW I   PG   R      D P   DV Y  I
Sbjct: 181 IDMVLMTPT---------ASMDDFTPSGEWDIVALPG---RRTVNPQD-PSYVDVTYDFI 227

Query: 236 IRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIP 295
           I+RKPLFY IN+I+PCVL + L +L ++LP+  G +K T+ I+VLLA T FL LI++ +P
Sbjct: 228 IKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCG-EKMTLCISVLLALTFFLLLISKIVP 286

Query: 296 ETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL- 354
            TSL VPL+G++L+F MV+ T  ++  V VLNV  R+P+TH M+P ++   L  LP  L 
Sbjct: 287 PTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLF 346

Query: 355 -GSPPPPEAPRAASPPRRA----------SSVGLLLRAEELILKKPRSELVFEGQRHRQG 403
              P P  +P  A PP ++          S+         +    P S       +   G
Sbjct: 347 MKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASA----ASKSPAG 402

Query: 404 TWTAA-----FCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNIC 458
           +   A     + +S G    +V+  ++ V+F+A+  ++ +     V DW  +   +D + 
Sbjct: 403 STPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLF 462

Query: 459 FWAALVLFSVGSSLIFLGAYF--NRVPDLPYA 488
            W  + +  +G+  +FL   F  +   + PYA
Sbjct: 463 LWVFMFVCVLGTVGLFLPPLFQTHAASEGPYA 494


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  301 bits (771), Expect = 9e-82
 Identities = 177/489 (36%), Positives = 271/489 (55%), Gaps = 32/489 (6%)

Query: 8   VLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKE 67
           +LLLL LL        E RL+  LF +Y+   RPV    D V I  +V+++ L+ ++E  
Sbjct: 19  LLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVN 78

Query: 68  ETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDAN 127
           + + T++W+   W DY+L ++  D+GG E +RVP++ +W P+IVL NN  G F V     
Sbjct: 79  QIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTK 138

Query: 128 VLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGK 187
            L+   G VTW+PPAI++S C ++VTYFPFD+QNC++ F S +Y+  +++        G 
Sbjct: 139 ALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLI----GS 194

Query: 188 TINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINI 247
           ++N  D     Y E+GEWAI   PG          +     D+ YSL IRR PLFY IN+
Sbjct: 195 SMNLKD-----YWESGEWAIIKAPGYKHDIKYNCCE-EIYPDITYSLYIRRLPLFYTINL 248

Query: 248 IVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRF 307
           I+PC+LIS L +L ++LP+   G+K T+ I+VLL+ TVFL +I + IP TSL +PL+G +
Sbjct: 249 IIPCLLISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEY 307

Query: 308 LIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAAS 367
           L+F M+  TL ++  V VLNV  RTPTTH M   ++ V L LLPR++    P      A 
Sbjct: 308 LLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQ 367

Query: 368 PPR-----RASSVGLLLRAEELILKK--PRSELVFEGQRHRQ---GTWTAAFCQ------ 411
            PR       S++    RAE    K+  P  + +     HR+     ++A   +      
Sbjct: 368 KPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSES 427

Query: 412 -----SLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLF 466
                SL A +PE++  + +V ++AE+ + Q    E   DW  +   +D I  W   ++ 
Sbjct: 428 VDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVC 487

Query: 467 SVGSSLIFL 475
            +G++ +FL
Sbjct: 488 ILGTAGLFL 496


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  298 bits (764), Expect = 6e-81
 Identities = 174/491 (35%), Positives = 267/491 (54%), Gaps = 67/491 (13%)

Query: 24  ELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDY 83
           E RL+ HLF  Y+  +RPV    D V +   +++  LI ++EK + +TT+VW+  +W DY
Sbjct: 59  EDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDY 118

Query: 84  RLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAI 143
           +L ++  DFG I +LRVPSE++W+P+IVL NN DG+F V +     ++  G+V W+PPAI
Sbjct: 119 KLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAI 178

Query: 144 YRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENG 203
           Y+S C+++VT+FPFD QNC + F S TY+  +++                +D + Y E+G
Sbjct: 179 YKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQT---------VDLKDYWESG 229

Query: 204 EWAIDFCPGVI--RRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLA 261
           EWAI    G    +++   A   P   DV Y+ +IRR PLFY IN+I+PC+LIS L +L 
Sbjct: 230 EWAIVNATGTYNSKKYDCCAEIYP---DVTYAFVIRRLPLFYTINLIIPCLLISCLTVLV 286

Query: 262 YFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMN 321
           ++LP+  G +K T+ I+VLL+ TVFL LI + IP TSL +PL+G +L+F M+  TL ++ 
Sbjct: 287 FYLPSDCG-EKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVI 345

Query: 322 CVIVLNVSQRTPTTHAMSPRLRHVLLELLPR--LLGSPPPP------------------- 360
            V VLNV  R+P+TH M   +R  LL  +PR  L+  PPPP                   
Sbjct: 346 TVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLE 405

Query: 361 -------------EAPRAASPPRRASSVGLLLRAEELI--LKKPRSE-LVFEGQRHRQGT 404
                        E  R A     A SVG L     L      P++E L+ EG+      
Sbjct: 406 SNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGEL----- 460

Query: 405 WTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALV 464
                       +P ++  ++ V+++A+  R ++A      DW  +   +D I  W  ++
Sbjct: 461 ----------LLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFII 510

Query: 465 LFSVGSSLIFL 475
           +  +G+  +FL
Sbjct: 511 VCFLGTIGLFL 521


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  290 bits (743), Expect = 2e-78
 Identities = 167/471 (35%), Positives = 254/471 (53%), Gaps = 29/471 (6%)

Query: 19  VGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGI 78
           VG   E RL+H LF++Y+   RPV    D VT+  +V +T L +++E  + + T++W+  
Sbjct: 29  VGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRH 88

Query: 79  DWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTW 138
            W DY+L +   ++ GIETLRVP++ +W P+IVL NN  G F V      L+   G +TW
Sbjct: 89  IWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITW 148

Query: 139 LPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEA 198
            PPAI++S C +++T+FPFD QNCSL F S TY+  E++           I    +D   
Sbjct: 149 TPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL---------LIIGSKVDMND 199

Query: 199 YTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLV 258
           + EN EW I    G          +    TD+ YS  IRR P+FY IN+I+PC+ IS L 
Sbjct: 200 FWENSEWEIIDASGYKHDIKYNCCE-EIYTDITYSFYIRRLPMFYTINLIIPCLFISFLT 258

Query: 259 LLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLI 318
           +L ++LP+   G+K T+ I+VLL+ TVFL +I + IP TSL VPL+G +L+F M+  TL 
Sbjct: 259 VLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLS 317

Query: 319 VMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL------------GSPPPPEAPRAA 366
           ++  V VLN+  RTPTTH M   ++ V L+LLP++L            GS   P      
Sbjct: 318 IVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARR 377

Query: 367 SPPRRASSVGLLLRAEELILKKPRSELVFEGQR--HRQGTWTAAFCQSLGAAAPEVRCCV 424
               + +S G     +E       +EL    +R  H+   W     +     +PEV   +
Sbjct: 378 PAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEH----SPEVEDVI 433

Query: 425 DAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFL 475
           ++V F+AE+ +    T E   DW  +   +D +  W  +++   G++ +FL
Sbjct: 434 NSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFL 484


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  276 bits (707), Expect = 2e-74
 Identities = 146/356 (41%), Positives = 220/356 (61%), Gaps = 19/356 (5%)

Query: 5   PLGVLLLLGLLGRG----VGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNL 60
           PL +LL  GLL          + E RL   LF+ Y+  SRPV    D V +   +++  L
Sbjct: 14  PLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQL 73

Query: 61  ISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF 120
           I ++EK + +TT+VW+  +W DY+L +   D+  + ++R+PSEL+W P+IVL NN DG F
Sbjct: 74  IDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDF 133

Query: 121 GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF 180
            V +     ++  G V W PPAIY+S C+++VT+FPFD QNC++ F S TY+  +++   
Sbjct: 134 AVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLV- 192

Query: 181 AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGV--IRRHHGGATDGPGETDVIYSLIIRR 238
              N    ++++D     + E+GEW I    G    R++   A   P   D+ Y+ +IRR
Sbjct: 193 ---NMHSRVDQLD-----FWESGEWVIVDAVGTYNTRKYECCAEIYP---DITYAFVIRR 241

Query: 239 KPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETS 298
            PLFY IN+I+PC+LIS L +L ++LP++  G+K T+ I+VLL+ TVFL LI + IP TS
Sbjct: 242 LPLFYTINLIIPCLLISCLTVLVFYLPSEC-GEKITLCISVLLSLTVFLLLITEIIPSTS 300

Query: 299 LSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL 354
           L +PL+G +L+F M+  TL ++  V VLNV  R+P TH M   +R V L+++PRLL
Sbjct: 301 LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLL 356



 Score = 30.0 bits (66), Expect = 5.0
 Identities = 12/59 (20%), Positives = 29/59 (49%)

Query: 417 APEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFL 475
           +P +   V+ V ++A+  + ++       DW  +   +D I  W  +++  +G+  +FL
Sbjct: 561 SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  276 bits (707), Expect = 2e-74
 Identities = 156/477 (32%), Positives = 264/477 (55%), Gaps = 42/477 (8%)

Query: 8   VLLLLGLLG------RGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLI 61
           VL++LG+          + +NE+  L  HLF  Y    RPV    DT+ +   + ++ L+
Sbjct: 8   VLIVLGIPSSATTGFNSIAENEDA-LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLV 66

Query: 62  SLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFG 121
            ++EK + +TT+VW+  +W D++L ++ DD+GGI +++VPSE +WLP+IVL  N DG+F 
Sbjct: 67  DVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFE 126

Query: 122 VAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFA 181
            +    V+V   G+V W PPA Y+S C ++VT+FPFD QNCS+ F S TY+   V+    
Sbjct: 127 GSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILI 186

Query: 182 VDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPL 241
            +N         +D + + +NGEW I    G+      G    P    + YS ++RR PL
Sbjct: 187 NEN---------VDRKDFFDNGEWEILNAKGMKGNRRDGVYSYP---FITYSFVLRRLPL 234

Query: 242 FYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSV 301
           FY + +I+PC+ +S L +L ++LP+   G+K ++S +VL++ TVFL +I + IP +S  +
Sbjct: 235 FYTLFLIIPCLGLSFLTVLVFYLPSDE-GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVI 293

Query: 302 PLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTT-HAMSPRLRHVLLELLPRLLGSPPPP 360
           PL+G +L+F+M+  TL ++  V V+NV  R+ +T H M+P ++ + L+ LP+LL      
Sbjct: 294 PLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCM--KD 351

Query: 361 EAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV 420
              R +SP +  S   +    +  +L+K + + + +G++        AF +         
Sbjct: 352 HVDRYSSPEKEESQPVV----KGKVLEKKKQKQLSDGEK-----VLVAFLEK-------- 394

Query: 421 RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGA 477
               D++ +++   + +    + V DW  +   LD I  W  L++   GS LIF  A
Sbjct: 395 --AADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPA 449


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  258 bits (658), Expect = 1e-68
 Identities = 146/474 (30%), Positives = 246/474 (51%), Gaps = 30/474 (6%)

Query: 5   PLGVLLLLGLLGRGV--GKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLIS 62
           P  +LLL  L   G+  G   E RL   LF +Y    RPV +    V +++ + L  LI+
Sbjct: 3   PWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLIN 62

Query: 63  LNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGV 122
           ++E  + +TT+V +   W DY L ++ DD+GG++ + +PSE +W P++VL NN DG F +
Sbjct: 63  VDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAI 122

Query: 123 AYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAV 182
                VL+   G +TW PPAI++S C + VT+FPFD QNCS+   + TY+   V      
Sbjct: 123 VKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES 182

Query: 183 DNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLF 242
           D           D   + E+GEW I    G                D+ Y  +++R PL+
Sbjct: 183 DQP---------DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLY 233

Query: 243 YVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVP 302
           +++N+I+PC+L S L  L ++LP  + G+K T+SI+VLL+ TVFL +I + IP TS +VP
Sbjct: 234 FIVNVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVP 292

Query: 303 LLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEA 362
           L+G++++F MV     ++  VIV+N   R+P+TH M   +R V ++ +P ++        
Sbjct: 293 LIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIM-------- 344

Query: 363 PRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRC 422
               S  +R S        E+   K    ++       + G     F   L    PEV+ 
Sbjct: 345 --FFSTMKRPS-------REKQDKKIFTEDIDISDISGKPGPPPMGFHSPL-IKHPEVKS 394

Query: 423 CVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLG 476
            ++ + ++AE+ +  + +    ++W  +   +D+I     +++  +G+  +F G
Sbjct: 395 AIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG 448


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  251 bits (642), Expect = 8e-67
 Identities = 149/459 (32%), Positives = 240/459 (52%), Gaps = 55/459 (11%)

Query: 19  VGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGI 78
           + K+E+  L   LF +Y+   RPV    D + I   + ++ L+ ++EK + +TT+VW+  
Sbjct: 43  IAKHED-SLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQ 101

Query: 79  DWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTW 138
           +W D +L ++ DD+GGI+ +RVPS+ VW P+IVL +N DG+F       V+ Y  G+VTW
Sbjct: 102 EWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRY-NGTVTW 160

Query: 139 LPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEA 198
            PPA Y+S C ++VT+FPFD QNCS+ F S TY+  +V+           +   D+D   
Sbjct: 161 TPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDI---------ILEDQDVDKRD 211

Query: 199 YTENGEWAIDFCPGVIRRHHGGATDG-PGETDVIYSLIIRRKPLFYVINIIVPCVLISGL 257
           + +NGEW I    G      G  TD       V YS +I+R PLFY + +I+PC+ +S L
Sbjct: 212 FFDNGEWEIVSATG----SKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFL 267

Query: 258 VLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATL 317
            +L ++LP+   G+K  +  +VL++ TVFL +I + IP +S  +PL+G +L+F M+  TL
Sbjct: 268 TVLVFYLPSNE-GEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTL 326

Query: 318 IVMNCVIVLNVSQRTPTTH-AMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVG 376
            +M  V  +N+  R+ +TH AM+P +R + L  LP+LL                      
Sbjct: 327 SIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLL---------------------C 365

Query: 377 LLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRD 436
           +    +    +K  +E    G +  + T  AA               +D++ ++      
Sbjct: 366 MRSHVDRYFTQKEETE-SGSGPKSSRNTLEAA---------------LDSIRYITRHIMK 409

Query: 437 QEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFL 475
           +    E V DW  +   LD +  W  L +  VGS  +F+
Sbjct: 410 ENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFV 448


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  245 bits (626), Expect = 6e-65
 Identities = 147/499 (29%), Positives = 248/499 (49%), Gaps = 55/499 (11%)

Query: 5   PLGVLLLLGLLGRGV--GKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLIS 62
           P  +LLL  L   G+  G   E RL   LF +Y    RPV +    V +++ + L  LI+
Sbjct: 3   PWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLIN 62

Query: 63  LNEKEETLTTSV----------------WIGI---------DWQDYRLNYSKDDFGGIET 97
           ++E  + +TT+V                 +G+          W DY L ++ DD+GG++ 
Sbjct: 63  VDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKK 122

Query: 98  LRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPF 157
           + +PSE +W P++VL NN DG F +     VL+   G +TW PPAI++S C + VT+FPF
Sbjct: 123 IHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPF 182

Query: 158 DWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRH 217
           D QNCS+   + TY+   V      D           D   + E+GEW I    G     
Sbjct: 183 DEQNCSMKLGTWTYDGSVVAINPESDQP---------DLSNFMESGEWVIKESRGWKHSV 233

Query: 218 HGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSI 277
                      D+ Y  +++R PL++++N+I+PC+L S L  L ++LP  + G+K T+SI
Sbjct: 234 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSI 292

Query: 278 NVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHA 337
           +VLL+ TVFL +I + IP TS +VPL+G++++F MV     ++  VIV+N   R+P+TH 
Sbjct: 293 SVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHV 352

Query: 338 MSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEG 397
           M   +R V ++ +P ++            S  +R S        E+   K    ++    
Sbjct: 353 MPNWVRKVFIDTIPNIM----------FFSTMKRPS-------REKQDKKIFTEDIDISD 395

Query: 398 QRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNI 457
              + G     F   L    PEV+  ++ + ++AE+ +  + +    ++W  +   +D+I
Sbjct: 396 ISGKPGPPPMGFHSPL-IKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHI 454

Query: 458 CFWAALVLFSVGSSLIFLG 476
                +++  +G+  +F G
Sbjct: 455 LLGVFMLVCIIGTLAVFAG 473


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  230 bits (587), Expect = 2e-60
 Identities = 136/458 (29%), Positives = 239/458 (52%), Gaps = 18/458 (3%)

Query: 26  RLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRL 85
           +L++ LF +Y    RPV + +  + ++L++TL+ +  ++E+ + LT  +WI   W D  L
Sbjct: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92

Query: 86  NYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYR 145
            + +D + G++++R+PS+LVW P+IVL N  D +     + NV++   G +TW  PAI +
Sbjct: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152

Query: 146 SVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEW 205
           S C V+VTYFPFD Q C+L F S TYN  +V+   A+D+          D   + E+ EW
Sbjct: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSG---------DLSDFIEDVEW 203

Query: 206 AIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLP 265
            +   P V      G    P   DV ++L+++R+  FY++N+++PCVLIS L  L+++LP
Sbjct: 204 EVHGMPAVKNVISYGCCSEP-YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLP 262

Query: 266 AQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIV 325
           A A G+K ++ + +LLA TVF  ++A+ +P  S +VPL+G++ I  M + T      ++V
Sbjct: 263 A-ASGEKVSLGVTILLAMTVFQLMVAEIMP-ASENVPLIGKYYIATMALITASTALTIMV 320

Query: 326 LNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPR-RASSVGLLLRAEEL 384
           +N+         +    R V+L+ + R+L      E+  +    R R     +  +  E 
Sbjct: 321 MNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPES 380

Query: 385 ILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCC-----VDAVNFVAESTRDQEA 439
            LK  R++ +   +   +       CQ       E  C         + ++A+  +D +A
Sbjct: 381 NLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKA 440

Query: 440 TGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGA 477
           T  + S+W ++   +D    W   ++  V + LI   A
Sbjct: 441 TNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARA 478


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  221 bits (563), Expect = 1e-57
 Identities = 148/505 (29%), Positives = 243/505 (48%), Gaps = 49/505 (9%)

Query: 1   MARAPLGVLLLLG--LLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLT 58
           M  +P GV L L   LL   +    + +LY  L  NY+P  RPV      +T+   ++L 
Sbjct: 1   MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL 60

Query: 59  NLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDG 118
            ++ ++EK + LTT++W+ + W D+ L ++  ++ G++T+R P   +W P+I+L N+ D 
Sbjct: 61  QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 120

Query: 119 QFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEF 178
           +F   +  NVLV   G   +LPP I++S C ++V +FPFD Q+C L F S +Y    ++ 
Sbjct: 121 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLD- 179

Query: 179 TFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRR 238
                     +   + D   Y  NGEW +   PG            P   DV +++ +RR
Sbjct: 180 ----------LQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTMRR 228

Query: 239 KPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETS 298
           + L+Y +N+++PCVLIS L LL + LPA + G+K ++ I VLL+ TVF+ L+A+ +P TS
Sbjct: 229 RTLYYGLNLLIPCVLISALALLVFLLPADS-GEKISLGITVLLSLTVFMLLVAEIMPATS 287

Query: 299 LSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPP 358
            SVPL+ ++    M++  L V+  VIVL      P    M    R +LL      L    
Sbjct: 288 DSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKR 347

Query: 359 PPE---APRAASPPRRASSVGLLLRAEELILKKPRS--ELVFEGQRHRQGTW------TA 407
           P E    P      RR S   + + A   +   P S   L++ G R   G        + 
Sbjct: 348 PGEDKVRPACQHKQRRCSLASVEMSA---VAPPPASNGNLLYIGFRGLDGVHCVPTPDSG 404

Query: 408 AFCQSLGAAA----------------PEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMG 451
             C  +  +                 P++   ++ V ++A   R Q+ +    S+W    
Sbjct: 405 VVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAA 464

Query: 452 NALDNICFWAALVLFSVGSSLIFLG 476
             +D +C    L+ FSV + +  +G
Sbjct: 465 CVVDRLC----LMAFSVFTIICTIG 485


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  211 bits (536), Expect = 2e-54
 Identities = 133/375 (35%), Positives = 203/375 (54%), Gaps = 24/375 (6%)

Query: 6   LGVLLLLGLLGRGVGKNEEL--RLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISL 63
           LG+LLL  L    +G    L  +L+  LF NY    RPV + + T+ ++L+VTL+ +I +
Sbjct: 10  LGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDM 69

Query: 64  NEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVA 123
           +E+ + LT  +WI  +W D  L +  + +GG++ +R+PS LVW P+IVL N  D Q   +
Sbjct: 70  DERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGS 129

Query: 124 YDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVD 183
              NV++   G+V W  PAI RS C V+V  FPFD Q+C L F S T+   +++    V 
Sbjct: 130 ASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLD----VR 185

Query: 184 NDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFY 243
             G   +  D     + EN EW +   P   R    G    P   DV ++L++RR+   Y
Sbjct: 186 PRGAAASLAD-----FVENVEWRVLGMPARRRVLTYGCCSEP-YPDVTFTLLLRRRAAAY 239

Query: 244 VINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPL 303
           V N+++PCVLIS L  LA+ LPA +G +K ++ + VLLA TVF  L+A+ +P    SVPL
Sbjct: 240 VCNLLLPCVLISLLAPLAFHLPADSG-EKVSLGVTVLLALTVFQLLLAESMPPAE-SVPL 297

Query: 304 LGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL-----GSP- 357
           +G++ +  M + T      ++++N+    P+   +    R +LL  L R L     G P 
Sbjct: 298 IGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPC 357

Query: 358 ----PPPEAPRAASP 368
               PP  +P   SP
Sbjct: 358 GQSRPPELSPSPQSP 372


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  166 bits (419), Expect = 6e-41
 Identities = 112/470 (23%), Positives = 216/470 (45%), Gaps = 46/470 (9%)

Query: 9   LLLLGLLGRGVGKNEE-------LRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLI 61
           LLL  LL +G  +          LRL  +L  NY  G RPVR+     T+S+ V +  ++
Sbjct: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77

Query: 62  SLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFG 121
           +++EK + LTT +W    W D  L ++ +DF  I  L +P++ +W+P+I++   +D    
Sbjct: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD---- 133

Query: 122 VAYDAN---VLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEF 178
           V    N   V +   G V    P    + C++++  FPFD QNCSL F S  +  +++  
Sbjct: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 179 TFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPG-ETDVIYSLIIR 237
           +       +   K+  D   +   GEW +    GV+      + +      ++ + ++IR
Sbjct: 194 SL-----WRLPEKVKSDRSVFMNQGEWEL---LGVLPYFREFSMESSNYYAEMKFYVVIR 245

Query: 238 RKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPET 297
           R+PLFYV+++++P + +  + ++ ++LP  + G++ +  I +LL  +VFL +++  +P T
Sbjct: 246 RRPLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPAT 304

Query: 298 SLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL--- 354
           ++  PL+G + +  M +  + +   + ++ +  +      +   LRH++LE +  LL   
Sbjct: 305 AIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLR 364

Query: 355 --GSPPPPEAPRAASPPRRASSVG---LLLRAEELILKKPRSELVFEGQRHRQGTWTAAF 409
              +   P A   A+     S++G     +   +   K PR                   
Sbjct: 365 EQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGL 424

Query: 410 CQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICF 459
            Q L +              + +    ++   E   DW+R+G+ LD + F
Sbjct: 425 LQELSS--------------IRQFLEKRDEIREVARDWLRVGSVLDKLLF 460


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  164 bits (415), Expect = 2e-40
 Identities = 106/447 (23%), Positives = 208/447 (46%), Gaps = 39/447 (8%)

Query: 25  LRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYR 84
           LRL  +L  NY  G RPVR+     T+S+ V +  +++++EK + LTT +W    W D  
Sbjct: 20  LRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEF 79

Query: 85  LNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDAN---VLVYEGGSVTWLPP 141
           L ++ +DF  I  L +P++ +W+P+I++   +D    V    N   V +   G V    P
Sbjct: 80  LQWNPEDFDNITKLSIPTDSIWVPDILINEFVD----VGKSPNIPYVYIRHQGEVQNYKP 135

Query: 142 AIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTE 201
               + C++++  FPFD QNCSL F S  +  +++  +       +   K+  D   +  
Sbjct: 136 LQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL-----WRLPEKVKSDRSVFMN 190

Query: 202 NGEWAIDFCPGVIRRHHGGATDGPG-ETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLL 260
            GEW +    GV+      + +      ++ + ++IRR+PLFYV+++++P + +  + ++
Sbjct: 191 QGEWEL---LGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIV 247

Query: 261 AYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVM 320
            ++LP  + G++ +  I +LL  +VFL +++  +P T++  PL+G + +  M +  + + 
Sbjct: 248 GFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLA 306

Query: 321 NCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL-----GSPPPPEAPRAASPPRRASSV 375
             + ++ +  +      +   LRH++LE +  LL      +   P A   A+     S++
Sbjct: 307 ETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM 366

Query: 376 G---LLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAE 432
           G     +   +   K PR                    Q L +              + +
Sbjct: 367 GNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSS--------------IRQ 412

Query: 433 STRDQEATGEEVSDWVRMGNALDNICF 459
               ++   E   DW+R+G+ LD + F
Sbjct: 413 FLEKRDEIREVARDWLRVGSVLDKLLF 439


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  151 bits (382), Expect = 1e-36
 Identities = 115/502 (22%), Positives = 220/502 (43%), Gaps = 78/502 (15%)

Query: 9   LLLLGLLGRGVGKNEE-------LRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLI 61
           LLL  LL +G  +          LRL  +L  NY  G RPVR+     T+S+ V +  ++
Sbjct: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77

Query: 62  SLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFG 121
           +++EK + LTT +W    W D  L ++ +DF  I  L +P++ +W+P+I++   +D    
Sbjct: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD---- 133

Query: 122 VAYDAN---VLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEF 178
           V    N   V +   G V    P    + C++++  FPFD QNCSL F S  +  +++  
Sbjct: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 179 TFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPG-ETDVIYSLIIR 237
           +       +   K+  D   +   GEW +    GV+      + +      ++ + ++IR
Sbjct: 194 SL-----WRLPEKVKSDRSVFMNQGEWEL---LGVLPYFREFSMESSNYYAEMKFYVVIR 245

Query: 238 RKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPET 297
           R+PLFYV+++++P + +  + ++ ++LP  + G++ +  I +LL  +VFL +++  +P T
Sbjct: 246 RRPLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPAT 304

Query: 298 SLSVPLLGRF------------------------------LIFVMVVATLIV--MNCVIV 325
           ++  PL+G+                               + FV+ +A L++     + +
Sbjct: 305 AIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFI 364

Query: 326 LNVSQRTPTTHAMSPRLRHVLLELLPRLL-----GSPPPPEAPRAASPPRRASSVG---L 377
           + +  +      +   LRH++LE +  LL      +   P A   A+     S++G    
Sbjct: 365 VRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCS 424

Query: 378 LLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQ 437
            +   +   K PR                    Q L +              + +    +
Sbjct: 425 HMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSS--------------IRQFLEKR 470

Query: 438 EATGEEVSDWVRMGNALDNICF 459
           +   E   DW+R+G+ LD + F
Sbjct: 471 DEIREVARDWLRVGSVLDKLLF 492


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  148 bits (374), Expect = 1e-35
 Identities = 111/387 (28%), Positives = 175/387 (45%), Gaps = 47/387 (12%)

Query: 117 DGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEV 176
           D +F   +  NVLV   G   +LPP I++S C ++V +FPFD Q+C L F S +Y    +
Sbjct: 29  DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 88

Query: 177 EFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLII 236
           +               + D   Y  NGEW +   PG            P   DV +++ +
Sbjct: 89  DLQMQ-----------EADISGYIPNGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTM 136

Query: 237 RRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPE 296
           RR+ L+Y +N+++PCVLIS L LL + LPA +G +K ++ I VLL+ TVF+ L+A+ +P 
Sbjct: 137 RRRTLYYGLNLLIPCVLISALALLVFLLPADSG-EKISLGITVLLSLTVFMLLVAEIMPA 195

Query: 297 TSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGS 356
           TS SVPL+ ++    M++  L V+  VIVL      P    M    R +LL      L  
Sbjct: 196 TSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRM 255

Query: 357 PPPPE---APRAASPPRRASSVGLLLRAEELILKKPRS--ELVFEGQRHRQGTW------ 405
             P E    P      RR S   + + A   +   P S   L++ G R   G        
Sbjct: 256 KRPGEDKVRPACQHKQRRCSLASVEMSA---VAPPPASNGNLLYIGFRGLDGVHCVPTPD 312

Query: 406 TAAFCQSLGAAA----------------PEVRCCVDAVNFVAESTRDQEATGEEVSDWVR 449
           +   C  +  +                 P++   ++ V ++A   R Q+ +    S+W  
Sbjct: 313 SGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKF 372

Query: 450 MGNALDNICFWAALVLFSVGSSLIFLG 476
               +D +C    L+ FSV + +  +G
Sbjct: 373 AACVVDRLC----LMAFSVFTIICTIG 395


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  125 bits (313), Expect = 1e-28
 Identities = 80/327 (24%), Positives = 155/327 (47%), Gaps = 23/327 (7%)

Query: 8   VLLLLGLLGRGVGKNEELRLYH---HLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLN 64
           +L+  G+L       ++  LYH    L   Y    RPV       T+ L + +  ++ ++
Sbjct: 13  ILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVD 72

Query: 65  EKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF--GV 122
            + + L TSVW    W D  L+++   F  I  + +P   +W P+I++   +D +    +
Sbjct: 73  AENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDL 132

Query: 123 AYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAV 182
            Y   V V   G++    P    S C++E   FPFD QNCSL F+S  +  E+V+  F  
Sbjct: 133 PY---VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFL- 188

Query: 183 DNDGKTINKIDIDTEAYTENGEW---AIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRK 239
               ++   I  D +A+  + EW   ++     +++   GG         + +++++RR 
Sbjct: 189 ----RSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGF------AQIQFNVVMRRH 238

Query: 240 PLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSL 299
           PL YV+++++P + +  + L +++LP      +     +VL+  TVF   ++ ++P +  
Sbjct: 239 PLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA-RIVFKTSVLVGYTVFRVNMSNQVPRSVG 297

Query: 300 SVPLLGRFLIFVMVVATLIVMNCVIVL 326
           S PL+G F    M    L +   ++++
Sbjct: 298 STPLIGHFFTICMAFLVLSLAKSIVLV 324


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  110 bits (274), Expect = 4e-24
 Identities = 69/308 (22%), Positives = 146/308 (47%), Gaps = 11/308 (3%)

Query: 40  RPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLR 99
           RPV        +++   ++ ++ +NE+   L++ +W+ + W +  ++++ ++  GI  + 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 100 VPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDW 159
           + ++ +WLP+I +   +D            V   G + +  P    S+C +++ YFPFD 
Sbjct: 130 MAAKNLWLPDIFIIELMDVD-KTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188

Query: 160 QNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHG 219
           QNC+L F S  Y  +    +  +D + +     D        +GEW +    G+ +    
Sbjct: 189 QNCTLTFSSFLYTVD----SMLLDMEKEVWEITDASRNILQTHGEWEL---LGLSKATAK 241

Query: 220 GATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINV 279
            +  G     +++ + IRR+P  YVIN++VP   +  +  L+++LP ++ G +    I +
Sbjct: 242 LSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKS-GNRVPFKITL 300

Query: 280 LLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMS 339
           LL   VFL +++  +P +    PL+G +    + +    ++  + + ++     T     
Sbjct: 301 LLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPL 358

Query: 340 PRLRHVLL 347
           PR  H LL
Sbjct: 359 PRWLHSLL 366


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  107 bits (267), Expect = 2e-23
 Identities = 87/311 (27%), Positives = 139/311 (44%), Gaps = 36/311 (11%)

Query: 193 DIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCV 252
           + D   Y  NGEW +   PG            P   DV +++ +RR+ L+Y +N+++PCV
Sbjct: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTMRRRTLYYGLNLLIPCV 61

Query: 253 LISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVM 312
           LIS L LL + LPA +G +K ++ I VLL+ TVF+ L+A+ +P TS SVPL+ ++    M
Sbjct: 62  LISALALLVFLLPADSG-EKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120

Query: 313 VVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPE---APRAASPP 369
           ++  L V+  VIVL      P    M    R +LL      L    P E    P      
Sbjct: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180

Query: 370 RRASSVGLLLRAEELILKKPRS--ELVFEGQRHRQGTW------TAAFCQSLGAAA---- 417
           RR S   + + A   +   P S   L++ G R   G        +   C  +  +     
Sbjct: 181 RRCSLASVEMSA---VAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDE 237

Query: 418 ------------PEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVL 465
                       P++   ++ V ++A   R Q+ +    S+W      +D +C    L+ 
Sbjct: 238 HLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLC----LMA 293

Query: 466 FSVGSSLIFLG 476
           FSV + +  +G
Sbjct: 294 FSVFTIICTIG 304


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  106 bits (265), Expect = 4e-23
 Identities = 69/308 (22%), Positives = 141/308 (45%), Gaps = 11/308 (3%)

Query: 40  RPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLR 99
           RP         +++  TL+ ++ ++ + + LT+ +W+ + W +  +N++  +  GI  L 
Sbjct: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114

Query: 100 VPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDW 159
           V +E +WLP+I +  ++D            +   G + +  P    S+C +++ YFPFD 
Sbjct: 115 VLAENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173

Query: 160 QNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHG 219
           QNC+  F S  Y  +    +  +  D +     D   +     GEW +    G+ +    
Sbjct: 174 QNCTFTFSSFLYTVD----SMLLGMDKEVWEITDTSRKVIQTQGEWEL---LGINKATPK 226

Query: 220 GATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINV 279
            +        +++ + IRR+P  Y+IN++VP   +  +  L+++LPA++   +    I +
Sbjct: 227 MSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAES-ENRAPFKITL 285

Query: 280 LLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMS 339
           LL   VFL ++   +P +    PL+  +    + +  + ++  V +  +     T     
Sbjct: 286 LLGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPM 343

Query: 340 PRLRHVLL 347
           PR  H LL
Sbjct: 344 PRWLHSLL 351


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 58/298 (19%), Positives = 125/298 (41%), Gaps = 25/298 (8%)

Query: 19  VGKNEELRL--YHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWI 76
           VG++++L L  + +L   Y+   RP    E  V I+L + + ++ S++E     T ++++
Sbjct: 30  VGRSDKLSLPGFENLTAGYNKFLRPNFGGEP-VQIALTLDIASISSISESNMDYTATIYL 88

Query: 77  GIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLV--YEGG 134
              W D RL +  +    ++   V  E +W+P+  +  +           N L+  +  G
Sbjct: 89  RQRWMDQRLVFEGNKSFTLDARLV--EFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNG 146

Query: 135 SVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDI 194
           +V +         C ++++ +P D Q C L   S  Y+  +VEFT+   ND         
Sbjct: 147 TVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGND--------- 197

Query: 195 DTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETD----VIYSLIIRRKPLFYVINIIVP 250
                +  G   +      I R+    T    ET     ++    +RR  L++++   VP
Sbjct: 198 -----SVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVP 252

Query: 251 CVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFL 308
              +  L  +++++   +   +  + +  +L+ T  +      +P T+  +  +  +L
Sbjct: 253 STFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYL 310


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 67/289 (23%), Positives = 128/289 (44%), Gaps = 24/289 (8%)

Query: 19  VGKNEELRLYHHLFNNYDPGSRPVRE--PEDTVTISLKVTLTNLISLNEKEETLTTSVWI 76
           V  N    + + L  +YDP  RP  +  P D V   + + + +  S+ E       ++++
Sbjct: 51  VPANSTSNILNRLLVSYDPRIRPNFKGIPVDVV---VNIFINSFGSIQETTMDYRVNIFL 107

Query: 77  GIDWQDYRLNYSKDDFGGIETLRVPSEL---VWLPEIVLENNIDGQFGVAYDANVLVY-- 131
              W D RL    D F G + L V   +   +W P++   N     F      N+L++  
Sbjct: 108 RQKWNDPRLKLPSD-FRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIF 166

Query: 132 -EGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTIN 190
            +G  +  +  +I  S C +++T FP D Q C +   S  Y  +++ F +    D   + 
Sbjct: 167 RDGDVLVSMRLSITLS-CPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQ-SGDPVQLE 224

Query: 191 KIDI-DTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIV 249
           KI +   +   E+ E+      G   +++ G T      +VI++L  RR+  FY++ +  
Sbjct: 225 KIALPQFDIKKEDIEY------GNCTKYYKG-TGYYTCVEVIFTL--RRQVGFYMMGVYA 275

Query: 250 PCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETS 298
           P +LI  L  L++++   A   +  + I  +L+       +A ++P+ S
Sbjct: 276 PTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVS 324


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 56/296 (18%), Positives = 129/296 (43%), Gaps = 31/296 (10%)

Query: 49  VTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLP 108
           V + + + + ++  ++E     T +++    W+D RL+Y+          RV  +L W+P
Sbjct: 60  VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQL-WVP 118

Query: 109 EIVLENNIDG-QFGVAYDANVL-VYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIF 166
           +    N+      GV     ++ ++  G+V +       + C +++  +P D QNC+L  
Sbjct: 119 DTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEI 178

Query: 167 RSQTYNAEEVEFTFAVDNDGKT-INKID------IDTEAYTENGEWAIDFCPGVIRRHHG 219
            S  Y  +++EF +  D++  T + KI+      +D +  T+     + F  G   R   
Sbjct: 179 ESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKK----VVFSTGSYPR--- 231

Query: 220 GATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINV 279
                     +  S  ++R   ++++   +P +LI+ L  +++++   A   +  + I  
Sbjct: 232 ----------LSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITT 281

Query: 280 LLAQTVFLFLIAQKIPE----TSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQR 331
           +L  T     + + +P+     ++ + L+G F+   M +    ++N +      QR
Sbjct: 282 VLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQR 337


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 56/296 (18%), Positives = 129/296 (43%), Gaps = 31/296 (10%)

Query: 49  VTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLP 108
           V + + + + ++  ++E     T +++    W+D RL+Y+          RV  +L W+P
Sbjct: 60  VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQL-WVP 118

Query: 109 EIVLENNIDG-QFGVAYDANVL-VYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIF 166
           +    N+      GV     ++ ++  G+V +       + C +++  +P D QNC+L  
Sbjct: 119 DTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEI 178

Query: 167 RSQTYNAEEVEFTFAVDNDGKT-INKID------IDTEAYTENGEWAIDFCPGVIRRHHG 219
            S  Y  +++EF +  D++  T + KI+      +D +  T+     + F  G   R   
Sbjct: 179 ESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKK----VVFSTGSYPR--- 231

Query: 220 GATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINV 279
                     +  S  ++R   ++++   +P +LI+ L  +++++   A   +  + I  
Sbjct: 232 ----------LSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITT 281

Query: 280 LLAQTVFLFLIAQKIPE----TSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQR 331
           +L  T     + + +P+     ++ + L+G F+   M +    ++N +      QR
Sbjct: 282 VLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQR 337


>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
           precursor [Homo sapiens]
          Length = 456

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 66/324 (20%), Positives = 131/324 (40%), Gaps = 53/324 (16%)

Query: 8   VLLLLGLLGRGVGK---NEEL--------RLYHHLFNNYDPGSRPVREPEDTVTISLKVT 56
           +LLL  L GR  G+    +EL        R+   L + YD   RP    E    +   + 
Sbjct: 15  ILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLG-ERVTEVKTDIF 73

Query: 57  LTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSEL---VWLPEIVLE 113
           +T+   +++ +   T  V+    W+D RL +     G +  LR+ + +   +W P+    
Sbjct: 74  VTSFGPVSDHDMEYTIDVFFRQSWKDERLKFK----GPMTVLRLNNLMASKIWTPDTFFH 129

Query: 114 NNIDGQFGVAYDANV-----LVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRS 168
           N   G+  VA++  +      + E G++ +      R+ C + +  FP D   C L F S
Sbjct: 130 N---GKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGS 186

Query: 169 QTYNAEEVEF--------TFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGG 220
             Y   EV +        +  V  DG  +N+ D+  +              G+++     
Sbjct: 187 YAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDS----------GIVQ----- 231

Query: 221 ATDGPGETDVIYS-LIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINV 279
                GE  V+ +   ++RK  ++VI   +PC++   L  ++++L  ++   +    +  
Sbjct: 232 --SSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTT 289

Query: 280 LLAQTVFLFLIAQKIPETSLSVPL 303
           +L  T         +P+ + +  +
Sbjct: 290 VLTMTTLSISARNSLPKVAYATAM 313


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.140    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,167,767
Number of Sequences: 37866
Number of extensions: 940570
Number of successful extensions: 5101
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 4917
Number of HSP's gapped (non-prelim): 117
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.