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Search of human proteins with 45439359
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
(3097 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 6191 0.0
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 3274 0.0
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 2611 0.0
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 562 e-159
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 461 e-129
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 461 e-129
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 238 7e-62
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 238 7e-62
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 227 1e-58
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 226 2e-58
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 224 8e-58
gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens] 221 9e-57
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 218 1e-55
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 218 1e-55
gi|148529025 pleckstrin homology domain containing, family G (wi... 204 1e-51
gi|14670383 death-associated kinase 2 [Homo sapiens] 200 2e-50
gi|193211603 pleckstrin homology domain containing, family G (wi... 194 1e-48
gi|193211598 pleckstrin homology domain containing, family G (wi... 194 1e-48
gi|193211596 pleckstrin homology domain containing, family G (wi... 194 1e-48
gi|193211594 pleckstrin homology domain containing, family G (wi... 194 1e-48
gi|55742734 pleckstrin homology domain containing, family G (wit... 194 1e-48
gi|157785645 SPEG complex locus [Homo sapiens] 188 8e-47
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 186 3e-46
gi|4758194 serine/threonine kinase 17B [Homo sapiens] 181 8e-45
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 181 8e-45
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 177 2e-43
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 177 2e-43
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 174 1e-42
gi|167466233 myosin light chain kinase family, member 4 [Homo sa... 174 2e-42
gi|146219832 myosin light chain kinase 3 [Homo sapiens] 166 3e-40
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 6191 bits (16061), Expect = 0.0
Identities = 3097/3097 (100%), Positives = 3097/3097 (100%)
Query: 1 MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM 60
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM
Sbjct: 1 MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM 60
Query: 61 KAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVC 120
KAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVC
Sbjct: 61 KAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVC 120
Query: 121 KRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE 180
KRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
Sbjct: 121 KRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE 180
Query: 181 TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDI 240
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDI
Sbjct: 181 TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDI 240
Query: 241 LAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSG 300
LAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSG
Sbjct: 241 LAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSG 300
Query: 301 NADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK 360
NADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
Sbjct: 301 NADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK 360
Query: 361 GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIR 420
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIR
Sbjct: 361 GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIR 420
Query: 421 QIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDL 480
QIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDL
Sbjct: 421 QIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDL 480
Query: 481 EDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV 540
EDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
Sbjct: 481 EDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV 540
Query: 541 IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL 600
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL
Sbjct: 541 IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL 600
Query: 601 HRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFV 660
HRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFV
Sbjct: 601 HRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFV 660
Query: 661 RRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT 720
RRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
Sbjct: 661 RRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT 720
Query: 721 LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKI 780
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKI
Sbjct: 721 LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKI 780
Query: 781 KLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNN 840
KLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNN
Sbjct: 781 KLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNN 840
Query: 841 LTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR 900
LTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
Sbjct: 841 LTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR 900
Query: 901 KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKT 960
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKT
Sbjct: 901 KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKT 960
Query: 961 HQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTS 1020
HQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTS
Sbjct: 961 HQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTS 1020
Query: 1021 EQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN 1080
EQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
Sbjct: 1021 EQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN 1080
Query: 1081 ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQY 1140
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQY
Sbjct: 1081 ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQY 1140
Query: 1141 VVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLI 1200
VVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLI
Sbjct: 1141 VVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLI 1200
Query: 1201 QLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ 1260
QLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
Sbjct: 1201 QLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ 1260
Query: 1261 LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLW 1320
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLW
Sbjct: 1261 LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLW 1320
Query: 1321 EMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKF 1380
EMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKF
Sbjct: 1321 EMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKF 1380
Query: 1381 QMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL 1440
QMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
Sbjct: 1381 QMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL 1440
Query: 1441 TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTL 1500
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTL
Sbjct: 1441 TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTL 1500
Query: 1501 IRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVG 1560
IRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVG
Sbjct: 1501 IRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVG 1560
Query: 1561 RTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR 1620
RTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
Sbjct: 1561 RTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR 1620
Query: 1621 DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRG 1680
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRG
Sbjct: 1621 DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRG 1680
Query: 1681 QTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVS 1740
QTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVS
Sbjct: 1681 QTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVS 1740
Query: 1741 SNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH 1800
SNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
Sbjct: 1741 SNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH 1800
Query: 1801 KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEG 1860
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEG
Sbjct: 1801 KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEG 1860
Query: 1861 EEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSK 1920
EEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSK
Sbjct: 1861 EEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSK 1920
Query: 1921 MALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET 1980
MALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
Sbjct: 1921 MALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET 1980
Query: 1981 ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLED 2040
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLED
Sbjct: 1981 ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLED 2040
Query: 2041 PEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKP 2100
PEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKP
Sbjct: 2041 PEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKP 2100
Query: 2101 VQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVA 2160
VQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVA
Sbjct: 2101 VQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVA 2160
Query: 2161 QGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV 2220
QGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV
Sbjct: 2161 QGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV 2220
Query: 2221 SCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNAL 2280
SCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNAL
Sbjct: 2221 SCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNAL 2280
Query: 2281 TSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSR 2340
TSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSR
Sbjct: 2281 TSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSR 2340
Query: 2341 IPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAE 2400
IPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAE
Sbjct: 2341 IPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAE 2400
Query: 2401 GSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSP 2460
GSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSP
Sbjct: 2401 GSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSP 2460
Query: 2461 LSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPG 2520
LSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPG
Sbjct: 2461 LSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPG 2520
Query: 2521 KDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQI 2580
KDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQI
Sbjct: 2521 KDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQI 2580
Query: 2581 LASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRK 2640
LASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRK
Sbjct: 2581 LASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRK 2640
Query: 2641 KSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGE 2700
KSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGE
Sbjct: 2641 KSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGE 2700
Query: 2701 TVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCI 2760
TVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCI
Sbjct: 2701 TVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCI 2760
Query: 2761 AVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKR 2820
AVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKR
Sbjct: 2761 AVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKR 2820
Query: 2821 AVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDC 2880
AVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDC
Sbjct: 2821 AVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDC 2880
Query: 2881 VVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDA 2940
VVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDA
Sbjct: 2881 VVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDA 2940
Query: 2941 VQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET 3000
VQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET
Sbjct: 2941 VQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET 3000
Query: 3001 CLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV 3060
CLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV
Sbjct: 3001 CLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV 3060
Query: 3061 LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV 3097
LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV
Sbjct: 3061 LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV 3097
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 3274 bits (8490), Expect = 0.0
Identities = 1625/2265 (71%), Positives = 1934/2265 (85%), Gaps = 70/2265 (3%)
Query: 51 RSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISY 110
R FR ND +KA DVLPILKEKVA++SGGRDKRGGPILTFPARSNHDRIRQEDLR+L++Y
Sbjct: 22 RGSFR-NDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTY 80
Query: 111 LACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRT 170
LA +PSE+VCKRGFTVI+DMRGSKWD IKPLLK LQE+FP IHVALIIKPDNFWQKQ+T
Sbjct: 81 LASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKT 140
Query: 171 NFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHM 230
NFGSSKF FET+MVS+EGLTK+VDPSQLT EFDG L+YNHEEWIE+R++ E++ ++A H+
Sbjct: 141 NFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHL 200
Query: 231 LSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSE 290
LSRLE+LQ++LA+KE P D+EG+R +I+EH+QLKKKV+KAP+E+LD EGQ+LLQ I+ S+
Sbjct: 201 LSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD 260
Query: 291 SFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 350
F +N G+AD Q+L+PK++++LD+LHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE
Sbjct: 261 GFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 320
Query: 351 KMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVE 410
KMFDWI+HNK LFL S+TEIG S+ +A++LQTQHNHFAMN MN YVNINRIMSVA+RL E
Sbjct: 321 KMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSE 380
Query: 411 SGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGE 470
+GHYASQQI+QI++QL+QEWK+FAAALDERST+L MS++FHQKAE+++S VD+WCK C E
Sbjct: 381 AGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSE 440
Query: 471 VDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANY 530
LPSE+QDLE AIHHHQ +YE +T AY+EVSQDGK+LLD LQRPL+PG+S+SLTA+ANY
Sbjct: 441 GGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANY 500
Query: 531 SKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL 590
SKAVH VLDV+HEVLHHQR+LE+IWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL
Sbjct: 501 SKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL 560
Query: 591 SKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAH 650
SKHTGVGKSLHRARALQKRH+DFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIY+AA
Sbjct: 561 SKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAAR 620
Query: 651 QLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLI 710
LE RIQDFVRRVEQRK+LLDMSVSFHTH KELWTW+E+LQKE+L+DV A+SV+AVQ+LI
Sbjct: 621 HLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELI 680
Query: 711 KRFGQQQQTTLQVTVNVIKEGEDLIQQL-------------RDSAISSNKTPHNSSINHI 757
K+F QQQ TL T+NVIKEGEDLIQQL RDSA+S+NKTPH+SSI+HI
Sbjct: 681 KQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHI 740
Query: 758 ETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFD 817
E+VLQQLD+AQ QMEELF ERKIKL++FLQLRIFE+ I++ ++L++WN++L +QMNDF+
Sbjct: 741 ESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFN 800
Query: 818 TEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATR 877
TEDLT+AEQRLQ H ++ L MNN+TF+VI QGQDL QY+ EVQASG+EL+C++D+D+A +
Sbjct: 801 TEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQ 860
Query: 878 VQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITA 937
VQ+LLEFLHEKQ EL+L AEQ K LEQC+QLRHLQAEVKQVLGWIRNGESMLNA L+ A
Sbjct: 861 VQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNA 920
Query: 938 SSLQEAEQLQREHEQFQHAIE---------KTHQSALQVQQKAEAMLQANHYDMDMIRDC 988
SSL EAEQLQREHEQFQ AIE KTHQSALQVQQKAE +LQA HYD D IR+C
Sbjct: 921 SSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIREC 980
Query: 989 AEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLG 1048
AEKVA HWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEY+R+EDWCGG DKLG
Sbjct: 981 AEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLG 1040
Query: 1049 PNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNMPGMVTHIKAPEQQ 1108
P +E DHV P+ISKHLEQKEAFLKACTLARRNA+VFLKY+HRN+V+MP + +H + PEQQ
Sbjct: 1041 PAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQ 1100
Query: 1109 VKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTST 1168
VK IL+EL QRENRVLH+WT++KRRLDQCQQYVVFERSAKQAL+WI + GEFYLSTHTST
Sbjct: 1101 VKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTST 1160
Query: 1169 GSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRY 1228
G + + TQELLKE+ EF++ AKQTKE+VKLLIQLAD F EKGH HA EI+K VT VDK Y
Sbjct: 1161 GETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHY 1220
Query: 1229 RDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRK 1288
RDFSLRM KYR SLEKALG++++ N K L+LDIIPAS+ EVKLRDA HE+NEEKRK
Sbjct: 1221 RDFSLRMGKYRYSLEKALGVNTEDN---KDLELDIIPASLSDREVKLRDANHEVNEEKRK 1277
Query: 1289 SARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIY 1348
SAR+KEFIMAEL+QTEKAYVRDL EC++TYLWEMTSGVEEIPPGI+NKE IIFGN+QEIY
Sbjct: 1278 SARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIY 1337
Query: 1349 EFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEI 1408
+FHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDS QLILEHAG++FDEI
Sbjct: 1338 DFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEI 1397
Query: 1409 QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAM 1468
QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE+KDGLEVMLSVPK+ANDAM
Sbjct: 1398 QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAM 1457
Query: 1469 HLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGR 1528
H+SMLEGFDEN++ QGELILQ++FQVWDPK+LIRKGRERHLFLFE+SLVFSKE+KDSSG
Sbjct: 1458 HVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGH 1517
Query: 1529 SKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIRE 1588
+KY+YK+KL TSELGVTEHVEGDPCKFALW GRTP+SDNK VLKAS+IE KQ+WIK+IRE
Sbjct: 1518 TKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIRE 1577
Query: 1589 VIQERTIHLKGALKEPIHIPKTAPATRQKGRRDG-EDLDSQGDGSSQPDTISIASRTSQN 1647
VIQER IHLKGALKEP+ +PKT R +RDG ED+DSQGDGSSQPDTISIASRTSQN
Sbjct: 1578 VIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTSQN 1637
Query: 1648 TLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAA 1707
T+DSDKLSGGCELTVV+ DF+A +S+ELTI+ GQTVE+LERP ++P WCLVRTT+RSP
Sbjct: 1638 TVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPL 1697
Query: 1708 EGLVPCGSLCIAHSRSSMEMEGIFN-HKDSLSVSSND-ASPPASVASL--QPHMIGAQSS 1763
EGLVP +LCI+HSRSS+EM+ F KD+ S SS++ SVA+L QP + SS
Sbjct: 1698 EGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIHSS 1757
Query: 1764 PGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKHKKSREVRKSADAGSQKDSDDSAA 1823
PGPKR NTL+KWLTSPVRRL+SGKADG++K K KK R+ RKS D GS K D++
Sbjct: 1758 PGPKRSTNTLKKWLTSPVRRLNSGKADGNIK----KQKKVRDGRKSFDLGSPKPGDET-- 1811
Query: 1824 TPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQP 1883
TPQ ++ +E+ + + GE+E +E + PLPPPM I +
Sbjct: 1812 TPQGDSADEKSK-----------------KGWGEDEPDEESH-TPLPPPMKIFDND---- 1849
Query: 1884 DSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFN 1943
+QD+ +SS L R S+E P+AA+LV+AIE+LVK+K++LE +G P+
Sbjct: 1850 PTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSY-----RGSLKDPA-G 1903
Query: 1944 PSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDG 2003
+ + + P + EE+K+ +L+ R +VL ELV+TE+DYV+DLG VVEG+M ++E G
Sbjct: 1904 CLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKG 1963
Query: 2004 VPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQ 2063
VP+DM+GKDKIVFGNIHQIYDWH+DFFL ELEKC+++ ++L LF+KHER+LH+Y+ YCQ
Sbjct: 1964 VPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQ 2023
Query: 2064 NKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASL 2123
NKP+SE+IV+EY D +FE++KQ + RL L+D LIKP+QRI KYQLLLKDFL+YS+KA L
Sbjct: 2024 NKPRSEYIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGL 2082
Query: 2124 DTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRC 2183
+ S++E+AVE+MC+VP+RCNDMMN+GRLQGF+G + AQGKLL QDTF V + DAG+ R
Sbjct: 2083 ECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRT 2142
Query: 2184 RERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTG 2243
+ERR+FLFEQIVIFSE L +KG PG++FK SIK++ L LEENV+NDPCKFAL +R
Sbjct: 2143 KERRVFLFEQIVIFSELL--RKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNR-- 2198
Query: 2244 DVVETFILHSSSPSVRQTWIHEINQILENQRNFLNALTSPIEYQR 2288
+ E +L +++ ++Q W+ +INQ+LE QR+FLNAL SPIEYQR
Sbjct: 2199 ETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQR 2243
Score = 388 bits (997), Expect = e-107
Identities = 181/313 (57%), Positives = 244/313 (77%), Gaps = 1/313 (0%)
Query: 2782 DGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHEL 2841
DG ++WK+NFDS Y+E+ E+GRGRFS+VKKC K T++ VA KFV+KK+ K++Q HE
Sbjct: 2670 DGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEA 2729
Query: 2842 GILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLE 2901
+LQ LQHP + L DT+E+PTSYIL+LE+ D GRLLD ++ L E K+ ++ +++E
Sbjct: 2730 ALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIME 2789
Query: 2902 AVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAP 2961
A++YLHNCR+AHLD+KPEN+L+D + P +KL D DAVQ++ ++IH LLGNPEFAAP
Sbjct: 2790 ALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAP 2849
Query: 2962 EIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQ 3021
E+I G PVSL +D WS+GVLTYV+LSGVSPFLD+S EETC+N+CR+DFSFP +YF GVS
Sbjct: 2850 EVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSN 2909
Query: 3022 KAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV-LDTSRLTSFIERRKHQNDVR 3080
A++F+ +LQED +RP+AA LQ WLQ NG + + LDTSRL FIERRKHQNDVR
Sbjct: 2910 AARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVR 2969
Query: 3081 PIRSIKNFLQSRL 3093
PI ++K+++ +R+
Sbjct: 2970 PIPNVKSYIVNRV 2982
Score = 235 bits (600), Expect = 4e-61
Identities = 144/341 (42%), Positives = 200/341 (58%), Gaps = 44/341 (12%)
Query: 2462 SSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPGK 2521
S+AV P +SP +SS+PA P ++ L+ T + +PG
Sbjct: 2247 STAVMRSQPARLPQASPRP-----YSSVPAGSEKPPKGSSYNPPLPPLKISTS-NGSPGF 2300
Query: 2522 DTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQIL 2581
+ + AS+Q+ + + S+M V DY A+KE+EI V QGEVVQ+L
Sbjct: 2301 EYHQPGDKFEASKQN---------DLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVL 2351
Query: 2582 ASNQQNMFLVFRAATDQCPAAEGWIPGFVLGH-TSAVIVENPDGTLKKSTSWHTALRLRK 2640
A NQQNM LV++ A+D PAAEGW+PG +L T A E+ DG++KKS SWHT LR+RK
Sbjct: 2352 AVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHT-LRMRK 2410
Query: 2641 KSEKKDKDGKREGKLENGYRKSREGLSNKVSVK--------------------LLNPNYI 2680
++E ++ GK E G RK ++ L NKVSVK +LNPN+I
Sbjct: 2411 RAEVENT-GKNEA---TGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFI 2466
Query: 2681 YDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGH---YSISYS 2737
+V PEF++PL +VTC G+TV+L+C+VCGRPK +ITWKGP+ N L+ D Y++S
Sbjct: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Query: 2738 DLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
D GE TLKI + +D GIYTCIA ND G+ S+SA+++V G
Sbjct: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 2567
Score = 235 bits (599), Expect = 6e-61
Identities = 167/527 (31%), Positives = 280/527 (53%), Gaps = 52/527 (9%)
Query: 1284 EEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGN 1343
E+K K+ R + F++ EL+QTEK YV+DL ++ ++ + + +P + K+ I+FGN
Sbjct: 1921 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEE--KGVPEDMRGKDKIVFGN 1978
Query: 1344 MQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGS 1403
+ +IY++H + FL ELEK Q + + F+ K +YV YC+NKP S ++ E+ +
Sbjct: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037
Query: 1404 YFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKD---GLEVMLSV 1460
YF+E++Q ++S +LIKP+QRITKYQLLLK+ L E+ E D +E+M V
Sbjct: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097
Query: 1461 PKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIR-KGRERHLFLFEMSLVFS 1519
PKR ND M+L L+GF+ + +QG+L+ Q++F V + ++ + +ER +FLFE ++FS
Sbjct: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFS 2157
Query: 1520 KEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENK 1579
+ ++ S Y++K + + L + E+V+ DPCKFAL T ++VL+A++ + +
Sbjct: 2158 ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRET---SERVVLQAANADIQ 2214
Query: 1580 QDWIKHIREVIQERTIHLKGALKEPIHIPK----TAPATRQKGRRD------------GE 1623
Q W++ I +V++ + L AL+ PI + TA Q R G
Sbjct: 2215 QAWVQDINQVLETQRDFLN-ALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGS 2273
Query: 1624 DLDSQGDGSSQP-DTISIASRTSQNTLD----SDKLS-------GGCELT---VVIHDFT 1668
+ +G + P + I++ + DK GGC T VI D+
Sbjct: 2274 EKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYY 2333
Query: 1669 ACNSNELTIRRGQTVEVLERPHDKPDWCLVR--TTDRSPAAEGLVPCGSLCIAHSRSSME 1726
A NE+ + +G+ V+VL ++ + CLV +D SPAAEG VP GS+ ++++
Sbjct: 2334 ALKENEICVSQGEVVQVLAV--NQQNMCLVYQPASDHSPAAEGWVP-GSILAPLTKATAA 2390
Query: 1727 MEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTL 1773
+ K S S + A V + G + GP++P + L
Sbjct: 2391 ESSDGSIKKSCSWHTLRMRKRAEVEN-----TGKNEATGPRKPKDIL 2432
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 2611 bits (6767), Expect = 0.0
Identities = 1273/1626 (78%), Positives = 1464/1626 (90%), Gaps = 27/1626 (1%)
Query: 51 RSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISY 110
R FR ND +KA DVLPILKEKVA++SGGRDKRGGPILTFPARSNHDRIRQEDLR+L++Y
Sbjct: 22 RGSFR-NDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTY 80
Query: 111 LACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRT 170
LA +PSE+VCKRGFTVI+DMRGSKWD IKPLLK LQE+FP IHVALIIKPDNFWQKQ+T
Sbjct: 81 LASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKT 140
Query: 171 NFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHM 230
NFGSSKF FET+MVS+EGLTK+VDPSQLT EFDG L+YNHEEWIE+R++ E++ ++A H+
Sbjct: 141 NFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHL 200
Query: 231 LSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSE 290
LSRLE+LQ++LA+KE P D+EG+R +I+EH+QLKKKV+KAP+E+LD EGQ+LLQ I+ S+
Sbjct: 201 LSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD 260
Query: 291 SFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 350
F +N G+AD Q+L+PK++++LD+LHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE
Sbjct: 261 GFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 320
Query: 351 KMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVE 410
KMFDWI+HNK LFL S+TEIG S+ +A++LQTQHNHFAMN MN YVNINRIMSVA+RL E
Sbjct: 321 KMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSE 380
Query: 411 SGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGE 470
+GHYASQQI+QI++QL+QEWK+FAAALDERST+L MS++FHQKAE+++S VD+WCK C E
Sbjct: 381 AGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSE 440
Query: 471 VDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANY 530
LPSE+QDLE AIHHHQ +YE +T AY+EVSQDGK+LLD LQRPL+PG+S+SLTA+ANY
Sbjct: 441 GGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANY 500
Query: 531 SKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL 590
SKAVH VLDV+HEVLHHQR+LE+IWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL
Sbjct: 501 SKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL 560
Query: 591 SKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAH 650
SKHTGVGKSLHRARALQKRH+DFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIY+AA
Sbjct: 561 SKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAAR 620
Query: 651 QLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLI 710
LE RIQDFVRRVEQRK+LLDMSVSFHTH KELWTW+E+LQKE+L+DV A+SV+AVQ+LI
Sbjct: 621 HLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELI 680
Query: 711 KRFGQQQQTTLQVTVNVIKEGEDLIQQL-------------RDSAISSNKTPHNSSINHI 757
K+F QQQ TL T+NVIKEGEDLIQQL RDSA+S+NKTPH+SSI+HI
Sbjct: 681 KQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHI 740
Query: 758 ETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFD 817
E+VLQQLD+AQ QMEELF ERKIKL++FLQLRIFE+ I++ ++L++WN++L +QMNDF+
Sbjct: 741 ESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFN 800
Query: 818 TEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATR 877
TEDLT+AEQRLQ H ++ L MNN+TF+VI QGQDL QY+ EVQASG+EL+C++D+D+A +
Sbjct: 801 TEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQ 860
Query: 878 VQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITA 937
VQ+LLEFLHEKQ EL+L AEQ K LEQC+QLRHLQAEVKQVLGWIRNGESMLNA L+ A
Sbjct: 861 VQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNA 920
Query: 938 SSLQEAEQLQREHEQFQHAIE---------KTHQSALQVQQKAEAMLQANHYDMDMIRDC 988
SSL EAEQLQREHEQFQ AIE KTHQSALQVQQKAE +LQA HYD D IR+C
Sbjct: 921 SSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIREC 980
Query: 989 AEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLG 1048
AEKVA HWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEY+R+EDWCGG DKLG
Sbjct: 981 AEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLG 1040
Query: 1049 PNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNMPGMVTHIKAPEQQ 1108
P +E DHV P+ISKHLEQKEAFLKACTLARRNA+VFLKY+HRN+V+MP + +H + PEQQ
Sbjct: 1041 PAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQ 1100
Query: 1109 VKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTST 1168
VK IL+EL QRENRVLH+WT++KRRLDQCQQYVVFERSAKQAL+WI + GEFYLSTHTST
Sbjct: 1101 VKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTST 1160
Query: 1169 GSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRY 1228
G + + TQELLKE+ EF++ AKQTKE+VKLLIQLAD F EKGH HA EI+K VT VDK Y
Sbjct: 1161 GETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHY 1220
Query: 1229 RDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRK 1288
RDFSLRM KYR SLEKALG++++ N K L+LDIIPAS+ EVKLRDA HE+NEEKRK
Sbjct: 1221 RDFSLRMGKYRYSLEKALGVNTEDN---KDLELDIIPASLSDREVKLRDANHEVNEEKRK 1277
Query: 1289 SARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIY 1348
SAR+KEFIMAEL+QTEKAYVRDL EC++TYLWEMTSGVEEIPPGI+NKE IIFGN+QEIY
Sbjct: 1278 SARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIY 1337
Query: 1349 EFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEI 1408
+FHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDS QLILEHAG++FDEI
Sbjct: 1338 DFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEI 1397
Query: 1409 QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAM 1468
QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE+KDGLEVMLSVPK+ANDAM
Sbjct: 1398 QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAM 1457
Query: 1469 HLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGR 1528
H+SMLEGFDEN++ QGELILQ++FQVWDPK+LIRKGRERHLFLFE+SLVFSKE+KDSSG
Sbjct: 1458 HVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGH 1517
Query: 1529 SKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIRE 1588
+KY+YK+KL TSELGVTEHVEGDPCKFALW GRTP+SDNK VLKAS+IE KQ+WIK+IRE
Sbjct: 1518 TKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIRE 1577
Query: 1589 VIQERTIHLKGALKEPIHIPKTAPATRQKGRRDG-EDLDSQGDGSSQPDTISIASRTSQN 1647
VIQER IHLKGALKEP+ +PKT R +RDG ED+DSQGDGSSQPDTISIASRTSQN
Sbjct: 1578 VIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTSQN 1637
Query: 1648 TLDSDK 1653
T+DSDK
Sbjct: 1638 TVDSDK 1643
Score = 238 bits (606), Expect = 9e-62
Identities = 138/358 (38%), Positives = 211/358 (58%), Gaps = 16/358 (4%)
Query: 1958 EMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKE--DGVPDDMKGKDKIV 2015
E+ E K S +++ +++ EL++TE+ YVRDL +E Y+ M + +P + K+ I+
Sbjct: 1270 EVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHII 1329
Query: 2016 FGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEY 2075
FGNI +IYD+H + FL ELEK + PE +G FV + MY+ YC+NKP S ++ E+
Sbjct: 1330 FGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEH 1389
Query: 2076 IDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVM 2135
TFF++++QR G ++ LIKPVQRI KYQLLLK+ L ++ EL+ +EVM
Sbjct: 1390 AGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGK---GELKDGLEVM 1446
Query: 2136 CIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIV 2195
VP++ ND M+V L+GFD + QG+L+LQD F V D + L+ + RER +FLFE +
Sbjct: 1447 LSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS-LIRKGRERHLFLFEISL 1505
Query: 2196 IFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTS-RTGDVVETFILHSS 2254
+FS+ + G + +++KN + S L + E+VE DPCKFAL S RT +L +S
Sbjct: 1506 VFSKEIKDSSGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563
Query: 2255 SPSVRQTWIHEINQILENQRNFL-NALTSPIEY------QRNHSGGGGGGGSGGSGGG 2305
+ +Q WI I ++++ + L AL P++ QRN+S G G G
Sbjct: 1564 NIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDG 1621
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 562 bits (1449), Expect = e-159
Identities = 295/551 (53%), Positives = 398/551 (72%), Gaps = 41/551 (7%)
Query: 1740 SSNDASPPASVASLQ--PHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLA 1797
SS + SVA+LQ P + SSPGPKR NTL+KWLTSPVRRL+SGKADG++KK
Sbjct: 35 SSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKK-- 92
Query: 1798 HKHKKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGE 1857
KK R+ RKS D GS K D++ TPQ ++ +E+ + + GE
Sbjct: 93 --QKKVRDGRKSFDLGSPKPGDET--TPQGDSADEKSK-----------------KGWGE 131
Query: 1858 EEGEEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELV 1917
+E +E + PLPPPM I + +QD+ +SS L R S+E P+AA+LV+AIE+LV
Sbjct: 132 DEPDEESHT-PLPPPMKIFDND----PTQDEMSSSLLAARQASTEVPTAADLVNAIEKLV 186
Query: 1918 KSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQEL 1977
K+K++LE +G P+ + + + P + EE+K+ +L+ R +VL EL
Sbjct: 187 KNKLSLEGSSY-----RGSLKDPA-GCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNEL 240
Query: 1978 VETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKC 2037
V+TE+DYV+DLG VVEG+M ++E GVP+DM+GKDKIVFGNIHQIYDWH+DFFL ELEKC
Sbjct: 241 VQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKC 300
Query: 2038 LEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLL 2097
+++ ++L LF+KHER+LH+Y+ YCQNKP+SE+IV+EY D +FE++KQ + RL L+D L
Sbjct: 301 IQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DAYFEEVKQEINQRLTLSDFL 359
Query: 2098 IKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGK 2157
IKP+QRI KYQLLLKDFL+YS+KA L+ S++E+AVE+MC+VP+RCNDMMN+GRLQGF+G
Sbjct: 360 IKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGT 419
Query: 2158 IVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNS 2217
+ AQGKLL QDTF V + DAG+ R +ERR+FLFEQIVIFSE L +KG PG++FK S
Sbjct: 420 LTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELL--RKGSLTPGYMFKRS 477
Query: 2218 IKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFL 2277
IK++ L LEENV+NDPCKFAL +R + E +L +++ ++Q W+ +INQ+LE QR+FL
Sbjct: 478 IKMNYLVLEENVDNDPCKFALMNR--ETSERVVLQAANADIQQAWVQDINQVLETQRDFL 535
Query: 2278 NALTSPIEYQR 2288
NAL SPIEYQR
Sbjct: 536 NALQSPIEYQR 546
Score = 388 bits (997), Expect = e-107
Identities = 181/313 (57%), Positives = 244/313 (77%), Gaps = 1/313 (0%)
Query: 2782 DGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHEL 2841
DG ++WK+NFDS Y+E+ E+GRGRFS+VKKC K T++ VA KFV+KK+ K++Q HE
Sbjct: 973 DGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEA 1032
Query: 2842 GILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLE 2901
+LQ LQHP + L DT+E+PTSYIL+LE+ D GRLLD ++ L E K+ ++ +++E
Sbjct: 1033 ALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIME 1092
Query: 2902 AVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAP 2961
A++YLHNCR+AHLD+KPEN+L+D + P +KL D DAVQ++ ++IH LLGNPEFAAP
Sbjct: 1093 ALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAP 1152
Query: 2962 EIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQ 3021
E+I G PVSL +D WS+GVLTYV+LSGVSPFLD+S EETC+N+CR+DFSFP +YF GVS
Sbjct: 1153 EVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSN 1212
Query: 3022 KAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV-LDTSRLTSFIERRKHQNDVR 3080
A++F+ +LQED +RP+AA LQ WLQ NG + + LDTSRL FIERRKHQNDVR
Sbjct: 1213 AARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVR 1272
Query: 3081 PIRSIKNFLQSRL 3093
PI ++K+++ +R+
Sbjct: 1273 PIPNVKSYIVNRV 1285
Score = 235 bits (600), Expect = 4e-61
Identities = 144/341 (42%), Positives = 200/341 (58%), Gaps = 44/341 (12%)
Query: 2462 SSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPGK 2521
S+AV P +SP +SS+PA P ++ L+ T + +PG
Sbjct: 550 STAVMRSQPARLPQASPRP-----YSSVPAGSEKPPKGSSYNPPLPPLKISTS-NGSPGF 603
Query: 2522 DTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQIL 2581
+ + AS+Q+ + + S+M V DY A+KE+EI V QGEVVQ+L
Sbjct: 604 EYHQPGDKFEASKQN---------DLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVL 654
Query: 2582 ASNQQNMFLVFRAATDQCPAAEGWIPGFVLGH-TSAVIVENPDGTLKKSTSWHTALRLRK 2640
A NQQNM LV++ A+D PAAEGW+PG +L T A E+ DG++KKS SWHT LR+RK
Sbjct: 655 AVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHT-LRMRK 713
Query: 2641 KSEKKDKDGKREGKLENGYRKSREGLSNKVSVK--------------------LLNPNYI 2680
++E ++ GK E G RK ++ L NKVSVK +LNPN+I
Sbjct: 714 RAEVENT-GKNEA---TGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFI 769
Query: 2681 YDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGH---YSISYS 2737
+V PEF++PL +VTC G+TV+L+C+VCGRPK +ITWKGP+ N L+ D Y++S
Sbjct: 770 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 829
Query: 2738 DLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
D GE TLKI + +D GIYTCIA ND G+ S+SA+++V G
Sbjct: 830 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 870
Score = 235 bits (599), Expect = 6e-61
Identities = 167/527 (31%), Positives = 280/527 (53%), Gaps = 52/527 (9%)
Query: 1284 EEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGN 1343
E+K K+ R + F++ EL+QTEK YV+DL ++ ++ + + +P + K+ I+FGN
Sbjct: 224 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEE--KGVPEDMRGKDKIVFGN 281
Query: 1344 MQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGS 1403
+ +IY++H + FL ELEK Q + + F+ K +YV YC+NKP S ++ E+ +
Sbjct: 282 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 340
Query: 1404 YFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKD---GLEVMLSV 1460
YF+E++Q ++S +LIKP+QRITKYQLLLK+ L E+ E D +E+M V
Sbjct: 341 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400
Query: 1461 PKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIR-KGRERHLFLFEMSLVFS 1519
PKR ND M+L L+GF+ + +QG+L+ Q++F V + ++ + +ER +FLFE ++FS
Sbjct: 401 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFS 460
Query: 1520 KEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENK 1579
+ ++ S Y++K + + L + E+V+ DPCKFAL T ++VL+A++ + +
Sbjct: 461 ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRET---SERVVLQAANADIQ 517
Query: 1580 QDWIKHIREVIQERTIHLKGALKEPIHIPK----TAPATRQKGRRD------------GE 1623
Q W++ I +V++ + L AL+ PI + TA Q R G
Sbjct: 518 QAWVQDINQVLETQRDFLN-ALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGS 576
Query: 1624 DLDSQGDGSSQP-DTISIASRTSQNTLD----SDKLS-------GGCELT---VVIHDFT 1668
+ +G + P + I++ + DK GGC T VI D+
Sbjct: 577 EKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYY 636
Query: 1669 ACNSNELTIRRGQTVEVLERPHDKPDWCLVR--TTDRSPAAEGLVPCGSLCIAHSRSSME 1726
A NE+ + +G+ V+VL ++ + CLV +D SPAAEG VP GS+ ++++
Sbjct: 637 ALKENEICVSQGEVVQVLAV--NQQNMCLVYQPASDHSPAAEGWVP-GSILAPLTKATAA 693
Query: 1727 MEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTL 1773
+ K S S + A V + G + GP++P + L
Sbjct: 694 ESSDGSIKKSCSWHTLRMRKRAEVEN-----TGKNEATGPRKPKDIL 735
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens]
Length = 619
Score = 461 bits (1186), Expect = e-129
Identities = 273/581 (46%), Positives = 364/581 (62%), Gaps = 34/581 (5%)
Query: 1807 RKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQS-CGEEEGEEGAD 1865
R D ++ + A Q E+ G S G++S S++SG+ + G G
Sbjct: 51 RTEGDHRRDREHEVLAGALQPESYSIAG-----SEGSISASAASGLAAPSGPSSGLSSGP 105
Query: 1866 AVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVS-AIEELVKSKMALE 1924
P PP L S L T +++ A + +E + + L
Sbjct: 106 CSPGPPGPVSGLRRWLDH-------SKHCLSVETEADSGQAGPYENWMLEPALATGEELP 158
Query: 1925 DRP--SSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETER 1982
+ ++LL GD + P P + +L S +P E EE+K +L+R YVL ELVETE+
Sbjct: 159 ELTLLTTLLEGPGDKTQP---PEEETL--SQAPESE-EEQKKKALERSMYVLSELVETEK 212
Query: 1983 DYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE 2042
YV DLG +VEGYMA M GVP+ ++G+D+IVFGNI QIY+WHRD+FL EL++CL+DP+
Sbjct: 213 MYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPD 272
Query: 2043 KLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQ 2102
L LF+KHERRLHMY+ YCQNKPKSEH+VSE+ D++FE+L+Q+LGHRLQL DLLIKPVQ
Sbjct: 273 WLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQ 332
Query: 2103 RIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQG 2162
RIMKYQLLLKDFLKY +A +DT++LE+AVEVMC VP+RCNDMM +GRL+GF+GK+ AQG
Sbjct: 333 RIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQG 392
Query: 2163 KLLLQDTFLVTDQDAG--LLPRCRERRIFLFEQIVIFSEPL-DKKKGFSMPGFLFKNSIK 2219
KLL QDTF VT+ +AG L R RERR+FLFEQI+IFSE L +G + PG+++KNSIK
Sbjct: 393 KLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIK 452
Query: 2220 VSCLCLEENVENDPCKFALTSRTGD-VVETFILHSSSPSVRQTWIHEINQILENQRNFLN 2278
VSCL LE N++ DPC+FALTSR + ++ ++L ++ P++ Q WI + QILE+QR+FLN
Sbjct: 453 VSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLN 512
Query: 2279 ALTSPIEYQRNHSGGGGGGGSGGSG-GGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSR 2337
AL SPIEYQR S G G G G G G + GS H+ P + G PS S
Sbjct: 513 ALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHT--PIN-GSLPSLLLSP 569
Query: 2338 PSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPP 2378
+ + + L A +A S +P P PP
Sbjct: 570 KGEVARALL----PLDKQALGDIPQAPHDSPPVSPTPKTPP 606
Score = 236 bits (601), Expect = 3e-61
Identities = 131/370 (35%), Positives = 212/370 (57%), Gaps = 12/370 (3%)
Query: 1269 PGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE 1328
P E L A E+K+K+ R ++++EL++TEK YV DL + ++ Y+ T +
Sbjct: 176 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQG 233
Query: 1329 IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCK 1388
+P + ++ I+FGN+Q+IYE+H + FL+EL++ + P+ + F+ + MYV YC+
Sbjct: 234 VPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQ 293
Query: 1389 NKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG-- 1446
NKP S ++ E SYF+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 294 NKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGM 353
Query: 1447 -KGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKT---LIR 1502
+++ +EVM VPKR ND M L L GF+ + +QG+L+ Q++F V +P+ L
Sbjct: 354 DTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSS 413
Query: 1503 KGRERHLFLFEMSLVFSKEVKD---SSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWV 1559
+GRER +FLFE ++FS+ + + Y+YK+ + S LG+ +++GDPC+FAL
Sbjct: 414 RGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS 473
Query: 1560 GRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGR 1619
+ VL+A+ Q WIKH+ ++++ + L AL+ PI + T GR
Sbjct: 474 RGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEYQRRESQTNSLGR 532
Query: 1620 RDGEDLDSQG 1629
G + S G
Sbjct: 533 PRGPGVGSPG 542
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens]
Length = 580
Score = 461 bits (1185), Expect = e-129
Identities = 249/456 (54%), Positives = 322/456 (70%), Gaps = 18/456 (3%)
Query: 1928 SSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRD 1987
++LL GD + P P + +L S +P E EE+K +L+R YVL ELVETE+ YV D
Sbjct: 125 TTLLEGPGDKTQP---PEEETL--SQAPESE-EEQKKKALERSMYVLSELVETEKMYVDD 178
Query: 1988 LGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSL 2047
LG +VEGYMA M GVP+ ++G+D+IVFGNI QIY+WHRD+FL EL++CL+DP+ L L
Sbjct: 179 LGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL 238
Query: 2048 FVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKY 2107
F+KHERRLHMY+ YCQNKPKSEH+VSE+ D++FE+L+Q+LGHRLQL DLLIKPVQRIMKY
Sbjct: 239 FIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKY 298
Query: 2108 QLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQ 2167
QLLLKDFLKY +A +DT++LE+AVEVMC VP+RCNDMM +GRL+GF+GK+ AQGKLL Q
Sbjct: 299 QLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQ 358
Query: 2168 DTFLVTDQDAG--LLPRCRERRIFLFEQIVIFSEPL-DKKKGFSMPGFLFKNSIKVSCLC 2224
DTF VT+ +AG L R RERR+FLFEQI+IFSE L +G + PG+++KNSIKVSCL
Sbjct: 359 DTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLG 418
Query: 2225 LEENVENDPCKFALTSRTGD-VVETFILHSSSPSVRQTWIHEINQILENQRNFLNALTSP 2283
LE N++ DPC+FALTSR + ++ ++L ++ P++ Q WI + QILE+QR+FLNAL SP
Sbjct: 419 LEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSP 478
Query: 2284 IEYQRNHSGGGGGGGSGGSG-GGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIP 2342
IEYQR S G G G G G G + GS H+ P + G PS S +
Sbjct: 479 IEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHT--PIN-GSLPSLLLSPKGEVA 535
Query: 2343 QPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPP 2378
+ + L A +A S +P P PP
Sbjct: 536 RALL----PLDKQALGDIPQAPHDSPPVSPTPKTPP 567
Score = 236 bits (601), Expect = 3e-61
Identities = 131/370 (35%), Positives = 212/370 (57%), Gaps = 12/370 (3%)
Query: 1269 PGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE 1328
P E L A E+K+K+ R ++++EL++TEK YV DL + ++ Y+ T +
Sbjct: 137 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQG 194
Query: 1329 IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCK 1388
+P + ++ I+FGN+Q+IYE+H + FL+EL++ + P+ + F+ + MYV YC+
Sbjct: 195 VPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQ 254
Query: 1389 NKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG-- 1446
NKP S ++ E SYF+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 255 NKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGM 314
Query: 1447 -KGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKT---LIR 1502
+++ +EVM VPKR ND M L L GF+ + +QG+L+ Q++F V +P+ L
Sbjct: 315 DTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSS 374
Query: 1503 KGRERHLFLFEMSLVFSKEVKD---SSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWV 1559
+GRER +FLFE ++FS+ + + Y+YK+ + S LG+ +++GDPC+FAL
Sbjct: 375 RGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS 434
Query: 1560 GRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGR 1619
+ VL+A+ Q WIKH+ ++++ + L AL+ PI + T GR
Sbjct: 435 RGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEYQRRESQTNSLGR 493
Query: 1620 RDGEDLDSQG 1629
G + S G
Sbjct: 494 PRGPGVGSPG 503
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 238 bits (607), Expect = 7e-62
Identities = 210/691 (30%), Positives = 326/691 (47%), Gaps = 94/691 (13%)
Query: 1127 WTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQ 1186
+ + + +D+CQ + A+ AL+ I E +L T + IQ + KE+E
Sbjct: 503 YLLASQPVDKCQS----QDGAEAALQEI----EKFLETGAE--NKIQELNAIYKEYES-- 550
Query: 1187 ITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKAL 1246
I + E V+ + Q E H A +KK + + + R E S +
Sbjct: 551 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 610
Query: 1247 GISSDS-NKSSKSLQLDIIPASIPGSEV-KLRDAAHELNEEKRKSARRKEFIMAELIQTE 1304
GI S N SS+ L P SE+ + R EE+ A + +M+EL+ TE
Sbjct: 611 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 670
Query: 1305 KAYVRDLRECMDTYLWEMTSGVEE--IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKY 1362
+AYV +L ++ Y EM + + + G+ NK+ ++FGNM+EIY FHN IFL+ELE Y
Sbjct: 671 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 730
Query: 1363 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-SYFDEIQQRHGLANSISSY 1421
PE VG CF+ + FQ+Y YC+NKP S L + + +F E Q++ S+ SY
Sbjct: 731 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 790
Query: 1422 LIKPVQRITKYQLLLKELLTCCE--EGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDEN 1479
L+KPVQRITKYQLLLKE+L EG ++++ L +L + K ND+MHL + G+D N
Sbjct: 791 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 850
Query: 1480 IESQGELILQESFQVWDP--------KTLIR-KGRERHLFLFEMSLVFSKEVKDS-SGRS 1529
+ G+L++Q SF VW K L R K +RHLFL E +++F K+ +++ G
Sbjct: 851 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 910
Query: 1530 K---YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHI 1586
K Y YK L + +G+TE+V+GD KF +W + +++A + E K W+ I
Sbjct: 911 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 967
Query: 1587 REVIQE-----RTIHLKGALKEPIHIPKTAPATRQKGR-----------RDGEDLDSQGD 1630
R+V+ R AL++ +P AP + R R + L +G
Sbjct: 968 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGY 1027
Query: 1631 GSSQPDTISIA-----SRTSQ------------------NTLDSDKLSGGCELTVVIHDF 1667
SS P T S+TS N+ D+++ G +V +
Sbjct: 1028 VSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKY 1087
Query: 1668 TACNSNE------LTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHS 1721
T +E L +R G VE+++ + D L D + EG VP SL +
Sbjct: 1088 TVVADHEKGGPDALRVRSGDVVELVQ----EGDEGLWYVRDPTTGKEGWVPASSLSVRLG 1143
Query: 1722 RSSMEMEGIFNHKDSLSVSSNDASPPASVAS 1752
S + +SS+++SP ++V S
Sbjct: 1144 PSG----------SAQCLSSSESSPGSAVLS 1164
Score = 188 bits (478), Expect = 6e-47
Identities = 115/329 (34%), Positives = 191/329 (58%), Gaps = 19/329 (5%)
Query: 1960 EERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPD----DMKGKDKIV 2015
EE +S ++ RRH V+ EL++TER YV +L V+EGY A M + + K ++
Sbjct: 650 EEEESLAILRRH-VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVL 708
Query: 2016 FGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEY 2075
FGN+ +IY +H FL ELE + PE +G F++ +Y YCQNKP+SE + +
Sbjct: 709 FGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQC 768
Query: 2076 ID-TFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEV 2134
D FF++ +++L H+L L L+KPVQRI KYQLLLK+ LKYS+ +L+ A+
Sbjct: 769 SDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCE-GAEDLQEALSS 827
Query: 2135 MCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAG-----LLPRCR--ER 2186
+ + + ND M++ + G+DG + GKLL+Q +F V TD G L R + +R
Sbjct: 828 ILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQR 887
Query: 2187 RIFLFEQIVIFSEPLDKK-KGF-SMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGD 2244
+FL E+ V+F + ++ +G+ P + +K S+ ++ + + ENV+ D KF + +
Sbjct: 888 HLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNARE 947
Query: 2245 VVETFILHSSSPSVRQTWIHEINQILENQ 2273
E +I+ + +P ++ W++EI ++L +Q
Sbjct: 948 --EVYIVQAPTPEIKAAWVNEIRKVLTSQ 974
Score = 180 bits (456), Expect = 2e-44
Identities = 155/591 (26%), Positives = 258/591 (43%), Gaps = 72/591 (12%)
Query: 6 GGAAAPAASSGPAAAAS-----AAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM 60
GGA AS GP S G G GG G A + +F+ DE+
Sbjct: 29 GGAGPSPASHGPTHGPSDPRTCLPGRGAGGMRPHG--RGALGCCGLCSFYTCHGAAGDEI 86
Query: 61 KAMDVLPI--------LKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLA 112
D++P+ LK++ AYLSGGR + G P++TFP I ++ + +++YL
Sbjct: 87 MHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLT 146
Query: 113 CIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTN- 171
IPS + GF +++D R KW S+K + + SFP + + L+++P F+Q+ ++
Sbjct: 147 SIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDI 206
Query: 172 ---FGSSKFEFETNMVSLEGLTKV---VDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYIS 225
F F+ + ++ L + + +D SQLT + G L+Y H W+ R A E +
Sbjct: 207 AFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFAL 266
Query: 226 NATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDL---EGQKL 282
L+ LA+ ELP D++ +++ H++ K K EDL L EG +
Sbjct: 267 MVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKA----KEDLRLALKEGHSV 322
Query: 283 LQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQL 342
L+ ++ ++ + + S N D + V +L +L+ T + W + KL+QC QL
Sbjct: 323 LESLRELQA--EGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQL 380
Query: 343 RLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIM 402
R FEQ ++ I + ++T+IG S H L F V V R +
Sbjct: 381 RHFEQGFREV-KAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEK-SGVAVERARAL 438
Query: 403 SV-ANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNV 461
S+ +L+ + HYA IR +L F+A + R LL S H++ E M
Sbjct: 439 SLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM--- 495
Query: 462 DSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEV----SQDG-KSLLDKLQRPL 516
WC +GIY LA V SQDG ++ L ++++ L
Sbjct: 496 -KWC---------------------DEGIY---LLASQPVDKCQSQDGAEAALQEIEKFL 530
Query: 517 TPGSSDSLTASANYSKAVHHVL-----DVIHEVLHHQRQLENIWQHRKVRL 562
G+ + + K +L + + +V Q +E ++ R+ L
Sbjct: 531 ETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASL 581
Score = 64.7 bits (156), Expect = 1e-09
Identities = 73/338 (21%), Positives = 132/338 (39%), Gaps = 29/338 (8%)
Query: 808 ELSQQMNDFDTE--------DLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEV 859
+ +Q + F TE D+ L H +K + +G +L+ + E+
Sbjct: 270 QTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLREL 329
Query: 860 QASGVELLCDRD-VDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQ 918
QA G E ++D +D VQ LL L+E + D +H++ LEQC+QLRH + ++
Sbjct: 330 QAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE 389
Query: 919 VLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQAN 978
V + + +SL E L R+ F+ + A + E ++
Sbjct: 390 VKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNK 449
Query: 979 HYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYK 1035
HY +D IR +++ Q ++ R L++ S+ ++ TS + C E +
Sbjct: 450 HYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLAS 507
Query: 1036 REEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNM 1095
+ D C D G + + + E K L A Y S+
Sbjct: 508 QPVDKCQSQD--GAEAALQEIEKFLETGAENKIQELNAI------------YKEYESILN 553
Query: 1096 PGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRR 1133
++ H++ Q+ + + E+F R L R+ R
Sbjct: 554 QDLMEHVRKVFQKQAS-MEEVFHRRQASLKKLAARQTR 590
Score = 62.0 bits (149), Expect = 9e-09
Identities = 68/321 (21%), Positives = 129/321 (40%), Gaps = 29/321 (9%)
Query: 470 EVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASAN 529
E +LP+++Q + H + ++G S+L+ L+ GS S+
Sbjct: 284 ETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQL 343
Query: 530 YSKA-VHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEA 588
++A V +L ++E + + W + +L Q LQL F+Q ++V ++ +
Sbjct: 344 DNQATVQRLLAQLNET---EAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQK 400
Query: 589 FLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQA 648
++ T +G SL L + FEE + A L EQL + I
Sbjct: 401 -IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPK 459
Query: 649 AHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEE----LQKELLDDVYAE--S 702
+L F + +R+ LL S+ H ++ W +E L + +D ++ +
Sbjct: 460 CQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGA 519
Query: 703 VEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQ 762
A+Q++ K + +Q + KE E ++ Q + H+ V Q
Sbjct: 520 EAALQEIEKFLETGAENKIQELNAIYKEYESILNQ--------------DLMEHVRKVFQ 565
Query: 763 QLDEAQSQMEELFQERKIKLE 783
+ Q+ MEE+F R+ L+
Sbjct: 566 K----QASMEEVFHRRQASLK 582
Score = 48.1 bits (113), Expect = 1e-04
Identities = 50/241 (20%), Positives = 99/241 (41%), Gaps = 4/241 (1%)
Query: 1051 SETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSV--NMPGMVTHIKAPEQQ 1108
++ + ++ H E+K+ + LA + L+ L + P + +
Sbjct: 289 NDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQAT 348
Query: 1109 VKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTST 1168
V+ +L +L + E +W +++L+QC Q FE+ ++ ++ I D ++T T
Sbjct: 349 VQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDI 407
Query: 1169 GSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRY 1228
G+S+ H + LL++ F+ + ER + L + H I+ +
Sbjct: 408 GNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLC 467
Query: 1229 RDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLDI-IPASIPGSEVKLRDAAHELNEEKR 1287
FS + + R L K+L + S K I + AS P + + +D A +E
Sbjct: 468 DQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIE 527
Query: 1288 K 1288
K
Sbjct: 528 K 528
Score = 43.5 bits (101), Expect = 0.003
Identities = 32/140 (22%), Positives = 70/140 (50%), Gaps = 4/140 (2%)
Query: 675 SFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDL 734
SF VK+ L+ EL + V++ ++ +++ + +KEG +
Sbjct: 263 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 322
Query: 735 IQQLRD-SAISSNKTPHNSSINHIETV---LQQLDEAQSQMEELFQERKIKLELFLQLRI 790
++ LR+ A S + + +++ TV L QL+E ++ +E + + + KLE LQLR
Sbjct: 323 LESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRH 382
Query: 791 FERDAIDIISDLESWNDELS 810
FE+ ++ + L++ + +++
Sbjct: 383 FEQGFREVKAILDAASQKIA 402
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 238 bits (607), Expect = 7e-62
Identities = 210/691 (30%), Positives = 326/691 (47%), Gaps = 94/691 (13%)
Query: 1127 WTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQ 1186
+ + + +D+CQ + A+ AL+ I E +L T + IQ + KE+E
Sbjct: 450 YLLASQPVDKCQS----QDGAEAALQEI----EKFLETGAE--NKIQELNAIYKEYES-- 497
Query: 1187 ITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKAL 1246
I + E V+ + Q E H A +KK + + + R E S +
Sbjct: 498 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 557
Query: 1247 GISSDS-NKSSKSLQLDIIPASIPGSEV-KLRDAAHELNEEKRKSARRKEFIMAELIQTE 1304
GI S N SS+ L P SE+ + R EE+ A + +M+EL+ TE
Sbjct: 558 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 617
Query: 1305 KAYVRDLRECMDTYLWEMTSGVEE--IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKY 1362
+AYV +L ++ Y EM + + + G+ NK+ ++FGNM+EIY FHN IFL+ELE Y
Sbjct: 618 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 677
Query: 1363 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-SYFDEIQQRHGLANSISSY 1421
PE VG CF+ + FQ+Y YC+NKP S L + + +F E Q++ S+ SY
Sbjct: 678 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 737
Query: 1422 LIKPVQRITKYQLLLKELLTCCE--EGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDEN 1479
L+KPVQRITKYQLLLKE+L EG ++++ L +L + K ND+MHL + G+D N
Sbjct: 738 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 797
Query: 1480 IESQGELILQESFQVWDP--------KTLIR-KGRERHLFLFEMSLVFSKEVKDS-SGRS 1529
+ G+L++Q SF VW K L R K +RHLFL E +++F K+ +++ G
Sbjct: 798 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 857
Query: 1530 K---YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHI 1586
K Y YK L + +G+TE+V+GD KF +W + +++A + E K W+ I
Sbjct: 858 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 914
Query: 1587 REVIQE-----RTIHLKGALKEPIHIPKTAPATRQKGR-----------RDGEDLDSQGD 1630
R+V+ R AL++ +P AP + R R + L +G
Sbjct: 915 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGY 974
Query: 1631 GSSQPDTISIA-----SRTSQ------------------NTLDSDKLSGGCELTVVIHDF 1667
SS P T S+TS N+ D+++ G +V +
Sbjct: 975 VSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKY 1034
Query: 1668 TACNSNE------LTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHS 1721
T +E L +R G VE+++ + D L D + EG VP SL +
Sbjct: 1035 TVVADHEKGGPDALRVRSGDVVELVQ----EGDEGLWYVRDPTTGKEGWVPASSLSVRLG 1090
Query: 1722 RSSMEMEGIFNHKDSLSVSSNDASPPASVAS 1752
S + +SS+++SP ++V S
Sbjct: 1091 PSG----------SAQCLSSSESSPGSAVLS 1111
Score = 188 bits (478), Expect = 6e-47
Identities = 115/329 (34%), Positives = 191/329 (58%), Gaps = 19/329 (5%)
Query: 1960 EERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPD----DMKGKDKIV 2015
EE +S ++ RRH V+ EL++TER YV +L V+EGY A M + + K ++
Sbjct: 597 EEEESLAILRRH-VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVL 655
Query: 2016 FGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEY 2075
FGN+ +IY +H FL ELE + PE +G F++ +Y YCQNKP+SE + +
Sbjct: 656 FGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQC 715
Query: 2076 ID-TFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEV 2134
D FF++ +++L H+L L L+KPVQRI KYQLLLK+ LKYS+ +L+ A+
Sbjct: 716 SDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCE-GAEDLQEALSS 774
Query: 2135 MCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAG-----LLPRCR--ER 2186
+ + + ND M++ + G+DG + GKLL+Q +F V TD G L R + +R
Sbjct: 775 ILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQR 834
Query: 2187 RIFLFEQIVIFSEPLDKK-KGF-SMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGD 2244
+FL E+ V+F + ++ +G+ P + +K S+ ++ + + ENV+ D KF + +
Sbjct: 835 HLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNARE 894
Query: 2245 VVETFILHSSSPSVRQTWIHEINQILENQ 2273
E +I+ + +P ++ W++EI ++L +Q
Sbjct: 895 --EVYIVQAPTPEIKAAWVNEIRKVLTSQ 921
Score = 170 bits (431), Expect = 2e-41
Identities = 141/540 (26%), Positives = 243/540 (45%), Gaps = 65/540 (12%)
Query: 52 SGFRKNDEMKAMDVLPI--------LKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQED 103
+G + DE+ D++P+ LK++ AYLSGGR + G P++TFP I ++
Sbjct: 25 AGRSRPDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKE 84
Query: 104 LRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDN 163
+ +++YL IPS + GF +++D R KW S+K + + SFP + + L+++P
Sbjct: 85 FQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTG 144
Query: 164 FWQKQRTN----FGSSKFEFETNMVSLEGLTKV---VDPSQLTPEFDGCLEYNHEEWIEI 216
F+Q+ ++ F F+ + ++ L + + +D SQLT + G L+Y H W+
Sbjct: 145 FFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQ 204
Query: 217 RVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLD 276
R A E + L+ LA+ ELP D++ +++ H++ K K EDL
Sbjct: 205 RTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKA----KEDLR 260
Query: 277 L---EGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRK 333
L EG +L+ ++ ++ + + S N D + V +L +L+ T + W +
Sbjct: 261 LALKEGHSVLESLRELQA--EGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQ 318
Query: 334 LKLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMN 393
KL+QC QLR FEQ ++ I + ++T+IG S H L F
Sbjct: 319 QKLEQCLQLRHFEQGFREV-KAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEK-SG 376
Query: 394 VYVNINRIMSV-ANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQ 452
V V R +S+ +L+ + HYA IR +L F+A + R LL S H+
Sbjct: 377 VAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHR 436
Query: 453 KAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEV----SQDG-KS 507
+ E M WC +GIY LA V SQDG ++
Sbjct: 437 RLETSM----KWC---------------------DEGIY---LLASQPVDKCQSQDGAEA 468
Query: 508 LLDKLQRPLTPGSSDSLTASANYSKAVHHVL-----DVIHEVLHHQRQLENIWQHRKVRL 562
L ++++ L G+ + + K +L + + +V Q +E ++ R+ L
Sbjct: 469 ALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASL 528
Score = 64.7 bits (156), Expect = 1e-09
Identities = 73/338 (21%), Positives = 132/338 (39%), Gaps = 29/338 (8%)
Query: 808 ELSQQMNDFDTE--------DLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEV 859
+ +Q + F TE D+ L H +K + +G +L+ + E+
Sbjct: 217 QTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLREL 276
Query: 860 QASGVELLCDRD-VDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQ 918
QA G E ++D +D VQ LL L+E + D +H++ LEQC+QLRH + ++
Sbjct: 277 QAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE 336
Query: 919 VLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQAN 978
V + + +SL E L R+ F+ + A + E ++
Sbjct: 337 VKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNK 396
Query: 979 HYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYK 1035
HY +D IR +++ Q ++ R L++ S+ ++ TS + C E +
Sbjct: 397 HYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLAS 454
Query: 1036 REEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNM 1095
+ D C D G + + + E K L A Y S+
Sbjct: 455 QPVDKCQSQD--GAEAALQEIEKFLETGAENKIQELNAI------------YKEYESILN 500
Query: 1096 PGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRR 1133
++ H++ Q+ + + E+F R L R+ R
Sbjct: 501 QDLMEHVRKVFQKQAS-MEEVFHRRQASLKKLAARQTR 537
Score = 62.0 bits (149), Expect = 9e-09
Identities = 68/321 (21%), Positives = 129/321 (40%), Gaps = 29/321 (9%)
Query: 470 EVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASAN 529
E +LP+++Q + H + ++G S+L+ L+ GS S+
Sbjct: 231 ETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQL 290
Query: 530 YSKA-VHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEA 588
++A V +L ++E + + W + +L Q LQL F+Q ++V ++ +
Sbjct: 291 DNQATVQRLLAQLNET---EAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQK 347
Query: 589 FLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQA 648
++ T +G SL L + FEE + A L EQL + I
Sbjct: 348 -IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPK 406
Query: 649 AHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEE----LQKELLDDVYAE--S 702
+L F + +R+ LL S+ H ++ W +E L + +D ++ +
Sbjct: 407 CQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGA 466
Query: 703 VEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQ 762
A+Q++ K + +Q + KE E ++ Q + H+ V Q
Sbjct: 467 EAALQEIEKFLETGAENKIQELNAIYKEYESILNQ--------------DLMEHVRKVFQ 512
Query: 763 QLDEAQSQMEELFQERKIKLE 783
+ Q+ MEE+F R+ L+
Sbjct: 513 K----QASMEEVFHRRQASLK 529
Score = 48.1 bits (113), Expect = 1e-04
Identities = 50/241 (20%), Positives = 99/241 (41%), Gaps = 4/241 (1%)
Query: 1051 SETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSV--NMPGMVTHIKAPEQQ 1108
++ + ++ H E+K+ + LA + L+ L + P + +
Sbjct: 236 NDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQAT 295
Query: 1109 VKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTST 1168
V+ +L +L + E +W +++L+QC Q FE+ ++ ++ I D ++T T
Sbjct: 296 VQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDI 354
Query: 1169 GSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRY 1228
G+S+ H + LL++ F+ + ER + L + H I+ +
Sbjct: 355 GNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLC 414
Query: 1229 RDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLDI-IPASIPGSEVKLRDAAHELNEEKR 1287
FS + + R L K+L + S K I + AS P + + +D A +E
Sbjct: 415 DQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIE 474
Query: 1288 K 1288
K
Sbjct: 475 K 475
Score = 43.5 bits (101), Expect = 0.003
Identities = 32/140 (22%), Positives = 70/140 (50%), Gaps = 4/140 (2%)
Query: 675 SFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDL 734
SF VK+ L+ EL + V++ ++ +++ + +KEG +
Sbjct: 210 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 269
Query: 735 IQQLRD-SAISSNKTPHNSSINHIETV---LQQLDEAQSQMEELFQERKIKLELFLQLRI 790
++ LR+ A S + + +++ TV L QL+E ++ +E + + + KLE LQLR
Sbjct: 270 LESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRH 329
Query: 791 FERDAIDIISDLESWNDELS 810
FE+ ++ + L++ + +++
Sbjct: 330 FEQGFREVKAILDAASQKIA 349
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 227 bits (579), Expect = 1e-58
Identities = 143/418 (34%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 2684 PPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEA- 2742
PP + + +V +TG T + G P+ S+TW +++ +S G
Sbjct: 6356 PPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDST---RLSQQQEGTTY 6412
Query: 2743 TLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGPGM--DGIMVTWKDNFDSFYSEVA 2800
+L + V ++D G+YTC+A N G A L VLG D + + SFY
Sbjct: 6413 SLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLGGDNEPDSEKQSHRRKLHSFYEVKE 6472
Query: 2801 ELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFE 2860
E+GRG F VK+ KG K A KF+ + R Q E IL +L HPL+ GLLD FE
Sbjct: 6473 EIGRGVFGFVKRVQHKGNKILCAAKFIPLRSRTRAQAYRERDILAALSHPLVTGLLDQFE 6532
Query: 2861 TPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPEN 2920
T + IL+LE+ LLD + R G +TE +++ ++ +++E + YLH+ + HLD+KP N
Sbjct: 6533 TRKTLILILELCSSEELLDRLYRKGVVTEAEVKVYIQQLVEGLHYLHSHGVLHLDIKPSN 6592
Query: 2921 ILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGV 2980
IL+ A+ IK+ DFG A + G+PEF +PEII NPVS SD W++GV
Sbjct: 6593 ILMVHP-AREDIKICDFGFAQNITPAELQFSQYGSPEFVSPEIIQQNPVSEASDIWAMGV 6651
Query: 2981 LTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPS 3040
++Y+ L+ SPF +S T LN+ S+ +S+ AK+F+ LQ P RPS
Sbjct: 6652 ISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAAHLSEDAKDFIKATLQRAPQARPS 6711
Query: 3041 AALALQEQW-LQAGNGRSTGVLDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV 3097
AA L W L++ ++T +L + R + Q R + S K+ L R +P +
Sbjct: 6712 AAQCLSHPWFLKSMPAEEAHFINTKQLKFLLARSRWQ---RSLMSYKSILVMRSIPEL 6766
Score = 125 bits (314), Expect = 6e-28
Identities = 87/321 (27%), Positives = 168/321 (52%), Gaps = 22/321 (6%)
Query: 1282 LNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIF 1341
++E++ K+ R ++ EL+ +E+A+V +L+ +L + +P + ++ +IF
Sbjct: 5685 VSEDEYKA--RLSSVIQELLSSEQAFVEELQFLQSHHLQHLER-CPHVPIAVAGQKAVIF 5741
Query: 1342 GNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHA 1401
N+++I FH++ FL+EL++ + +DV CF+ F+ Y+ + + + +++ A
Sbjct: 5742 RNVRDIGRFHSS-FLQELQQCDT-DDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTA 5799
Query: 1402 -GSYFDEIQQRHGLANSISS--------YLIKPVQRITKYQLLLKELLTCCEEGKGE--- 1449
++ + + LA S YL +PV+R+ +YQ LLKEL+ +
Sbjct: 5800 IQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNRQNCAL 5859
Query: 1450 IKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIR---KGRE 1506
++ V+ ++P+RA + +H+S++E + +++ GE I Q F VW+ R KG
Sbjct: 5860 LEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMPWKGHN 5919
Query: 1507 RHLFLFEMSLVFSKEVKDS-SGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTS 1565
RH+FLF LV K +DS + Y++++ + S + + + VEGD F +W R S
Sbjct: 5920 RHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQER-EDS 5978
Query: 1566 DNKIVLKASSIENKQDWIKHI 1586
K +L+A + K W+K I
Sbjct: 5979 VRKYLLQARTAIIKSSWVKEI 5999
Score = 120 bits (300), Expect = 3e-26
Identities = 82/280 (29%), Positives = 137/280 (48%), Gaps = 10/280 (3%)
Query: 2801 ELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFE 2860
++ RGRFSVV++C +K + RA+A K + + V E L+ L+HP L L +
Sbjct: 7677 QIQRGRFSVVRQCWEKASGRALAAKIIPYHPKDKTAVLREYEALKGLRHPHLAQLHAAYL 7736
Query: 2861 TPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPEN 2920
+P +L+LE+ LL C+ S +E +++ +L ++L A +YLHN I HLDL+ EN
Sbjct: 7737 SPRHLVLILELCSGPELLPCLAERASYSESEVKDYLWQMLSATQYLHNQHILHLDLRSEN 7796
Query: 2921 ILVDESLAKPTIKLADFGDAVQLNTTYYI--HQLLGNPEFAAPEIILGNPVSLTSDTWSV 2978
+++ E +K+ D G+A L+ + + E APE++ G +D W++
Sbjct: 7797 MIITE---YNLLKVVDLGNAQSLSQEKVLPSDKFKDYLETMAPELLEGQGAVPQTDIWAI 7853
Query: 2979 GVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKR 3038
GV +++LS P + + + R + G+S A F+ L P R
Sbjct: 7854 GVTAFIMLSAEYPVSSEGARDLQRGL-RKGLVRLSRCYAGLSGGAVAFLRSTLCAQPWGR 7912
Query: 3039 PSAALALQEQWL----QAGNGRSTGVLDTSRLTSFIERRK 3074
P A+ LQ WL A + + T+RL F+ R+
Sbjct: 7913 PCASSCLQCPWLTEEGPACSRPAPVTFPTARLRVFVRNRE 7952
Score = 118 bits (295), Expect = 1e-25
Identities = 119/475 (25%), Positives = 220/475 (46%), Gaps = 62/475 (13%)
Query: 1817 DSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGE------EGADAVPLP 1870
DSD+ + TP R R S ++ +SSS G+ GE AD +PL
Sbjct: 5562 DSDEDSKTPSASPRHGRSR----PSSSIQESSSESED--GDARGEIFDIYVVTADYLPL- 5614
Query: 1871 PPMAIQQHSLLQPDSQ-----DDKASSRLLVR--PTSSETPSAAELVSAIEELVKSKMAL 1923
+Q ++ + Q D R LVR PT S +PS VS A
Sbjct: 5615 ---GAEQDAITLREGQYVEVLDAAHPLRWLVRTKPTKS-SPSRQGWVSP---------AY 5661
Query: 1924 EDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERD 1983
DR L + G + +P F + DE + R SS V+QEL+ +E+
Sbjct: 5662 LDRRLKLSPEWGAAEAPEFP-------GEAVSEDEYKARLSS-------VIQELLSSEQA 5707
Query: 1984 YVRDLGYVVEGYMALMKE-DGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE 2042
+V +L ++ ++ ++ VP + G+ ++F N+ I +H F L EL++C D +
Sbjct: 5708 FVEELQFLQSHHLQHLERCPHVPIAVAGQKAVIFRNVRDIGRFHSSF-LQELQQCDTDDD 5766
Query: 2043 KLGSLFVKHERRLHMYIAYCQNKPKSEHIV-SEYIDTFFEDLKQRL---GHRLQ-----L 2093
+ F+K++ Y+ + + ++E +V S I F++ + G Q L
Sbjct: 5767 -VAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTAIQEFYKKYAEEALLAGDPSQPPPPPL 5825
Query: 2094 TDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQG 2153
L +PV+R+ +YQ LLK+ ++ + + + LE+A V+ +P+R + ++V ++
Sbjct: 5826 QHYLEQPVERVQRYQALLKELIRNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMEN 5885
Query: 2154 FDGKIVAQGKLLLQDTFLVTDQDAGL-LP-RCRERRIFLFEQIVIFSEPLDKKKGFSMPG 2211
+ G + A G+ + Q F+V + G +P + R +FLF ++ +P + ++
Sbjct: 5886 YPGTLQALGEPIRQGHFIVWEGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRTDTV-S 5944
Query: 2212 FLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEI 2266
++F+N +K+S + L + VE D F + D V ++L + + ++ +W+ EI
Sbjct: 5945 YVFRNMMKLSSIDLNDQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEI 5999
Score = 59.7 bits (143), Expect = 4e-08
Identities = 39/127 (30%), Positives = 56/127 (44%), Gaps = 6/127 (4%)
Query: 2655 LENGYRKSREGLSNKVSVKLLNPNYI-----YDVPPEFVIPLSEVTCETGETVVLRCRVC 2709
+E G R+ +S + ++ P + D P F+ L + G V C V
Sbjct: 5091 VEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVT 5150
Query: 2710 GRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSAS 2769
G+P S+ W + L D HY I+ G L I V D G+Y C+A N MG +S
Sbjct: 5151 GQPMPSVRWF-KDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSS 5209
Query: 2770 SSASLRV 2776
+ A LRV
Sbjct: 5210 TKAELRV 5216
Score = 57.4 bits (137), Expect = 2e-07
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 1/96 (1%)
Query: 2684 PPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEAT 2743
PP+F L++ T E GETV L CRV G PK I+W + + D H+ + G
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWY-KDGKAVQVDPHHILIEDPDGSCA 6071
Query: 2744 LKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779
L + +T D G Y C A + G+ S+ + V P
Sbjct: 6072 LILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVP 6107
Score = 55.1 bits (131), Expect = 1e-06
Identities = 42/153 (27%), Positives = 70/153 (45%), Gaps = 17/153 (11%)
Query: 2649 GKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVLRCRV 2708
G+ EG + G + + GL++ L + +D P F+ LS+ T G++V L C+V
Sbjct: 7431 GRPEGLEKEGPPRKKPGLASFRLSGLKS----WDRAPTFLRELSDETVVLGQSVTLACQV 7486
Query: 2709 CGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSA 2768
+P A TW + L + IS + L I+ V ED G+YTC N +G+
Sbjct: 7487 SAQPAAQATW-SKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTV 7545
Query: 2769 SSSASLR------------VLGPGMDGIMVTWK 2789
+++ LR + DG+++ WK
Sbjct: 7546 TTTGVLRKAERPSSSPCPDIGEVYADGVLLVWK 7578
Score = 49.3 bits (116), Expect = 6e-05
Identities = 31/100 (31%), Positives = 42/100 (42%)
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDL 2739
+ VPP FV + GE C + G P I W + ++S
Sbjct: 6103 LVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRS 6162
Query: 2740 GEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779
G L I + ED G+Y C VN +GSA +SA LR+ P
Sbjct: 6163 GLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSP 6202
Score = 48.9 bits (115), Expect = 8e-05
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEAT- 2743
P F++ + + G RCRV G P+ +++W DG + +LGEA+
Sbjct: 110 PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGP-RVRVEELGEASA 168
Query: 2744 LKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
L+I D G Y A N +G+AS++A+L V
Sbjct: 169 LRIRAARPRDGGTYEVRAENPLGAASAAAALVV 201
Score = 44.7 bits (104), Expect = 0.001
Identities = 30/88 (34%), Positives = 39/88 (44%), Gaps = 3/88 (3%)
Query: 2695 TCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEA-TLKIVGVTTED 2753
T G+ L C V G PK WK + L +G + Y D E LKI+ D
Sbjct: 248 TVTEGKHARLSCYVTGEPKPETVWK--KDGQLVTEGRRHVVYEDAQENFVLKILFCKQSD 305
Query: 2754 DGIYTCIAVNDMGSASSSASLRVLGPGM 2781
G+YTC A N +G SS + V P +
Sbjct: 306 RGLYTCTASNLVGQTYSSVLVVVREPAV 333
Score = 44.7 bits (104), Expect = 0.001
Identities = 61/217 (28%), Positives = 84/217 (38%), Gaps = 47/217 (21%)
Query: 2311 GGAPSGGSGHSGGPS---SCGGAPSTSRSRPSRIPQPVRHHPPVLVSSAASSQAEADKMS 2367
GGAP GH G S GG P T+ QP R P S
Sbjct: 6991 GGAPIRDMGHPQGSKQLPSTGGHPGTA--------QPERPSPD----------------S 7026
Query: 2368 GTSTPGPSL-PPPGAAPEAGPS---APSRRPPGADAEGSEREAEPIPKMKVLESPRKGAA 2423
P P P G+AP+ G S A + PPG+ GS +EA +P L P+ A
Sbjct: 7027 PWGQPAPFCHPKQGSAPQEGCSPHPAVAPCPPGSFPPGSCKEAPLVPSSPFLGQPQAPPA 7086
Query: 2424 NASGSSPDAPAKDARASLGTLPL-GKPRAGAASPLNSPLSSAVPSLGKEPFPPSSPLQKG 2482
A S P D++ G + L G+P+ G P +SP S++ S + S L+ G
Sbjct: 7087 PAKAS----PPLDSKMGPGDISLPGRPKPG---PCSSPGSASQASSSQ-----VSSLRVG 7134
Query: 2483 GSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAP 2519
S + P G + +++ L TP P
Sbjct: 7135 SSQVGTEPGPSLDAEG---WTQEAEDLSDSTPTLQRP 7168
Score = 42.4 bits (98), Expect = 0.007
Identities = 35/129 (27%), Positives = 56/129 (43%), Gaps = 24/129 (18%)
Query: 2519 PGKDTDRMSTCSSASEQSVQSTQSNGSESSSSSN---------ISTMLVTHDY--TAVKE 2567
PG D+D S SAS + +S S+ + SSS + +VT DY ++
Sbjct: 5559 PGGDSDEDSKTPSASPRHGRSRPSSSIQESSSESEDGDARGEIFDIYVVTADYLPLGAEQ 5618
Query: 2568 DEINVYQGEVVQILASNQQNMFLVFRAATDQCPAAEGWI-PGFVLGHTSAVIVENPDGTL 2626
D I + +G+ V++L + +LV T P+ +GW+ P ++ D L
Sbjct: 5619 DAITLREGQYVEVLDAAHPLRWLVRTKPTKSSPSRQGWVSPAYL------------DRRL 5666
Query: 2627 KKSTSWHTA 2635
K S W A
Sbjct: 5667 KLSPEWGAA 5675
Score = 41.6 bits (96), Expect = 0.012
Identities = 29/100 (29%), Positives = 43/100 (43%), Gaps = 4/100 (4%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNT----LNNDGHYSISYSD 2738
VPP + + + G ++ +V GRP ++ W E + D S
Sbjct: 5369 VPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASS 5428
Query: 2739 LGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
+ +L ++ V + G YTCIA N G A SASL V G
Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSG 5468
Score = 38.9 bits (89), Expect = 0.080
Identities = 25/94 (26%), Positives = 37/94 (39%), Gaps = 1/94 (1%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATL 2744
P F + + G+ + L C V + W + L + H+ I G +L
Sbjct: 4898 PMFSHTFGDTEAQVGDALRLECVVASKADVRARWL-KDGVELTDGRHHHIDQLGDGTCSL 4956
Query: 2745 KIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
I G+ D G YTC N G + SA + V G
Sbjct: 4957 LITGLDRADAGCYTCQVSNKFGQVTHSACVVVSG 4990
Score = 38.5 bits (88), Expect = 0.10
Identities = 20/37 (54%), Positives = 23/37 (62%)
Query: 2743 TLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779
TL+I+ VT ED G Y N MG+A SSA L V GP
Sbjct: 5317 TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGP 5353
Score = 37.7 bits (86), Expect = 0.18
Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 10/98 (10%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITW-KGPEHNTLNNDGHYSISYSDLGE 2741
+P F+ + G T VL+C + A + W KG E TL YS+ D
Sbjct: 3800 LPARFIEDVKNQEAREGATAVLQCELS--KAAPVEWRKGSE--TLRGGDRYSLR-QDGTR 3854
Query: 2742 ATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779
L+I G++ D G Y+C+ G +SA+L V P
Sbjct: 3855 CELQIHGLSVADTGEYSCVC----GQERTSATLTVRAP 3888
Score = 37.4 bits (85), Expect = 0.23
Identities = 68/239 (28%), Positives = 92/239 (38%), Gaps = 39/239 (16%)
Query: 2315 SGGSGHSGGPSSCGGAP-STSRSRPSRIPQPVRH----HPPVLVSSAAS--SQAEADKMS 2367
+GGS S S AP + ++S P P PV H HP + +AS +AEA + S
Sbjct: 6786 TGGSSSSSSSSDNELAPFARAKSLP---PSPVTHSPLLHPRGFLRPSASLPEEAEASERS 6842
Query: 2368 GTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAEGSEREAEPIPKMKVLESPRKGAANASG 2427
T P P P GA P A R + + ESP GA
Sbjct: 6843 -TEAPAPPASPEGAGPPAAQGCVPR----------HSVIRSLFYHQAGESPEHGAL---- 6887
Query: 2428 SSPDAPAKDARASLGTLPLGKPRAGAASPLNSPL-SSAVPSLGKEPFPPSSPLQKGGSFW 2486
+P + AR L G AGA L PL V ++ L K SF
Sbjct: 6888 -APGSRRHPARRR--HLLKGGYIAGALPGLREPLMEHRVLEEEAAREEQATLLAKAPSFE 6944
Query: 2487 SSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPGKDTDRMSTCSSASEQSVQSTQSNGS 2545
+++ PAS G+ PG S SL+ +P T R S+ + Q + S S G+
Sbjct: 6945 TAL-RLPAS--GTHLAPGHSHSLEHDSP-------STPRPSSEACGEAQRLPSAPSGGA 6993
Score = 37.0 bits (84), Expect = 0.30
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEA 2742
+P +F L G T VLRC + WKG H TL + +S+ D
Sbjct: 3624 LPIKFTEGLRNEEATEGATAVLRCELSKMAPVE-WWKG--HETLRDGDRHSLR-QDGARC 3679
Query: 2743 TLKIVGVTTEDDGIYTCIAVNDMGSA 2768
L+I G+ ED G Y C+ + SA
Sbjct: 3680 ELQIRGLVAEDAGEYLCMCGKERTSA 3705
Score = 36.6 bits (83), Expect = 0.40
Identities = 31/103 (30%), Positives = 44/103 (42%), Gaps = 19/103 (18%)
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRV--CGRP----KASITWKGPEHNTLNNDGHYS 2733
+ + P F L++ T GE + L C C P K T +G L+++GH
Sbjct: 3091 VTEKPSVFSRELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSHEGH-- 3148
Query: 2734 ISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
A L I G T +D G Y C + G A SS+ +RV
Sbjct: 3149 -------RAQLLITGATLQDSGRYKC----EAGGACSSSIVRV 3180
Score = 35.8 bits (81), Expect = 0.68
Identities = 22/92 (23%), Positives = 36/92 (39%), Gaps = 2/92 (2%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATL 2744
P F+ G+ L C++ G P ++W+ + DL T
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLT- 68
Query: 2745 KIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
I+ + D G Y C A N +G A ++ L+V
Sbjct: 69 -ILDLALGDSGQYVCRARNAIGEAFAAVGLQV 99
Score = 35.8 bits (81), Expect = 0.68
Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 7/93 (7%)
Query: 2684 PPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEAT 2743
P F+ L +++ E T+ L+C V P+A + W+ + L Y ++ G
Sbjct: 2646 PVVFLKALDDLSAEERGTLALQCEVSD-PEAHVVWR-KDGVQLGPSDKYDFLHT-AGTRG 2702
Query: 2744 LKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
L + V+ ED G+YTC +GS + A +RV
Sbjct: 2703 LVVHDVSPEDAGLYTC----HVGSEETRARVRV 2731
Score = 35.4 bits (80), Expect = 0.88
Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 6/87 (6%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITW-KGPEHNTLNNDGHYSISYSDLGE 2741
+P F+ + G T VL+C + A + W KG E TL + YS+ D +
Sbjct: 3536 LPARFIEDVKNQEAREGATAVLQCEL--NSAAPVEWRKGSE--TLRDGDRYSLR-QDGTK 3590
Query: 2742 ATLKIVGVTTEDDGIYTCIAVNDMGSA 2768
L+I G+ D G Y+C+ + SA
Sbjct: 3591 CELQIRGLAMADTGEYSCVCGQERTSA 3617
Score = 34.3 bits (77), Expect = 2.0
Identities = 26/94 (27%), Positives = 42/94 (44%), Gaps = 8/94 (8%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEA 2742
+P +F+ L G+T L C + A + W+ H TL + +S+ D
Sbjct: 3712 MPSKFIEGLRNEEATEGDTATLWCELS--KAAPVEWR-KGHETLRDGDRHSLR-QDGSRC 3767
Query: 2743 TLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
L+I G+ D G Y+C+ G +SA+L V
Sbjct: 3768 ELQIRGLAVVDAGEYSCVC----GQERTSATLTV 3797
Score = 34.3 bits (77), Expect = 2.0
Identities = 29/93 (31%), Positives = 40/93 (43%), Gaps = 9/93 (9%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITW-KGPEHNTLNNDGHYSISYSDLGEAT 2743
P F PL + E G T L+C + P A++ W KG N + A
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGC---TAE 3945
Query: 2744 LKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
L + + ED G YTC GS ++SA+L V
Sbjct: 3946 LVLQDLQREDTGEYTCTC----GSQATSATLTV 3974
Score = 33.5 bits (75), Expect = 3.4
Identities = 36/114 (31%), Positives = 52/114 (45%), Gaps = 16/114 (14%)
Query: 1610 TAPATRQKGRRDGEDLD--------SQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELT 1661
+A T+ K + G D D S G S+P S +S + D D ++
Sbjct: 5548 SAKITQAKLQVPGGDSDEDSKTPSASPRHGRSRPS--SSIQESSSESEDGDARGEIFDIY 5605
Query: 1662 VVIHDFTACNSNE--LTIRRGQTVEVLERPHDKPDWCLVRT--TDRSPAAEGLV 1711
VV D+ + + +T+R GQ VEVL+ H P LVRT T SP+ +G V
Sbjct: 5606 VVTADYLPLGAEQDAITLREGQYVEVLDAAH--PLRWLVRTKPTKSSPSRQGWV 5657
Score = 33.1 bits (74), Expect = 4.4
Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 13/115 (11%)
Query: 2662 SREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGP 2721
S GL++K S+ + + P + PL + GE V LRC + R + W
Sbjct: 2810 SVRGLTSKASL------IVRERPAAIIKPLEDQWVAPGEDVELRCEL-SRAGTPVHWL-K 2861
Query: 2722 EHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
+ + Y + + A L I G + +D G YTC ++ ++ S+ASL V
Sbjct: 2862 DRKAIRKSQKYDV-VCEGTMAMLVIRGASLKDAGEYTC----EVEASKSTASLHV 2911
Score = 32.7 bits (73), Expect = 5.7
Identities = 27/99 (27%), Positives = 39/99 (39%), Gaps = 7/99 (7%)
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDL 2739
+ ++P F PL +V E V L C + RP + W + G +
Sbjct: 2161 VTELPVSFSRPLQDVVTTEKEKVTLECEL-SRPNVDVRWL--KDGVELRAGKTMAIAAQG 2217
Query: 2740 GEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
+L I D G+Y C D A SSAS++V G
Sbjct: 2218 ACRSLTIYRCEFADQGVYVC----DAHDAQSSASVKVQG 2252
Score = 32.3 bits (72), Expect = 7.5
Identities = 29/108 (26%), Positives = 47/108 (43%), Gaps = 3/108 (2%)
Query: 2677 PNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISY 2736
P + +V +F L V E G TV L C + A + W+ NT G
Sbjct: 1801 PVQVEEVAAKFCRLLEPVCGELGGTVTLACEL-SPACAEVVWRCG--NTQLRVGKRFQMV 1857
Query: 2737 SDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGPGMDGI 2784
++ +L ++G+ ED G Y C + +D SA + S+ + M G+
Sbjct: 1858 AEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGL 1905
Score = 32.0 bits (71), Expect = 9.8
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDL 2739
+ D+P PL T ++VVL C PKA +K + L+ + +S
Sbjct: 2464 VSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQWYK--DDTPLSPSEKFKMSLEG- 2520
Query: 2740 GEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
A L+I+ + D G+Y C A GSA SS + V
Sbjct: 2521 QMAELRILRLMPADAGVYRCQA----GSAHSSTEVTV 2553
Score = 32.0 bits (71), Expect = 9.8
Identities = 26/97 (26%), Positives = 39/97 (40%), Gaps = 8/97 (8%)
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDL 2739
I +P F+ L G T LRC + A + W+ + + D H D
Sbjct: 3357 IRPMPAHFIGRLRHQESIEGATATLRCELS--KAAPVEWRKGRESLRDGDRHSL--RQDG 3412
Query: 2740 GEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
L+I G+ D G Y+C+ G +SA+L V
Sbjct: 3413 AVCELQICGLAVADAGEYSCVC----GEERTSATLTV 3445
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 226 bits (577), Expect = 2e-58
Identities = 123/318 (38%), Positives = 182/318 (57%), Gaps = 13/318 (4%)
Query: 2789 KDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-------RDQVTHEL 2841
++N D +Y ELG G+F+VVKKC +K T A KF+ K+ K R+ + E+
Sbjct: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65
Query: 2842 GILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLE 2901
IL+ +QHP ++ L + +E T IL+LE+ G L D + SLTE + L ++L
Sbjct: 66 SILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILN 125
Query: 2902 AVRYLHNCRIAHLDLKPENI-LVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAA 2960
V YLH+ +IAH DLKPENI L+D ++ KP IK+ DFG A +++ + G PEF A
Sbjct: 126 GVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVA 185
Query: 2961 PEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVS 3020
PEI+ P+ L +D WS+GV+TY+LLSG SPFL D+ +ET N+ +++ F D+YF S
Sbjct: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTS 245
Query: 3021 QKAKEFVCFLLQEDPAKRPSAALALQEQWL-----QAGNGRSTGVLDTSRLTSFIERRKH 3075
AK+F+ LL +DP KR + +LQ W+ Q R ++ + F R+K
Sbjct: 246 ALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKW 305
Query: 3076 QNDVRPIRSIKNFLQSRL 3093
+ VR I + +S L
Sbjct: 306 KQSVRLISLCQRLSRSFL 323
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 224 bits (572), Expect = 8e-58
Identities = 113/285 (39%), Positives = 176/285 (61%), Gaps = 8/285 (2%)
Query: 2789 KDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-------RDQVTHEL 2841
+++ + Y ELG G+F++V+KC QKGT + A KF+ K+ + R+++ E+
Sbjct: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65
Query: 2842 GILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLE 2901
IL+ ++HP ++ L D FE T +L+LE+ G L D + SLTE + L ++L+
Sbjct: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILD 125
Query: 2902 AVRYLHNCRIAHLDLKPENI-LVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAA 2960
V YLH+ RIAH DLKPENI L+D+++ P IKL DFG A ++ + G PEF A
Sbjct: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185
Query: 2961 PEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVS 3020
PEI+ P+ L +D WS+GV+TY+LLSG SPFL ++ +ET NI +++ F ++YF S
Sbjct: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245
Query: 3021 QKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGVLDTSR 3065
+ AK+F+ LL +DP +R + A +L+ W++A R+ D+ R
Sbjct: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGR 290
>gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]
Length = 696
Score = 221 bits (563), Expect = 9e-57
Identities = 167/659 (25%), Positives = 308/659 (46%), Gaps = 34/659 (5%)
Query: 60 MKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEV 119
M+A +LPILK+K+A+LSGG+D+R G ILT P ++ ++L + YL IPSE+
Sbjct: 1 MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCL--EQTNMDELSVTLDYLLSIPSEKC 58
Query: 120 CKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNF----GSS 175
RGFTVIVD R S+W+ +K ++ +LQ P + + ++KPD FW K+ T+F
Sbjct: 59 KARGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKD 118
Query: 176 KFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLE 235
+ FE +VS LT+ ++P QLT +F G L Y+H +W+ R+ FE + +T +L L
Sbjct: 119 RLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELA 178
Query: 236 ELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLE-GQKLLQRIQSSESFPK 294
+ + K N E+ + + + + L+ G +LL +Q F
Sbjct: 179 LINNGSDKG----------NQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRR-FNG 227
Query: 295 KNSGSGNADLQNLL---PKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEK 351
+ G + + + L P+V +LD L ++ R + QL +Q +
Sbjct: 228 SDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVMQ 283
Query: 352 MFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMN---VYVNINRIMSVANRL 408
+ +W+ L + IG S + LQ +H VYV +N+ +A L
Sbjct: 284 VVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQ--QIAALL 341
Query: 409 VESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWC-KA 467
+++ + QL A+ L+ R LL + FH A+ +D
Sbjct: 342 NAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGML 401
Query: 468 CGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTAS 527
C +V P++ ++ + + + + + + + G+ LLD++ + +T
Sbjct: 402 CVDV-APADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIE 460
Query: 528 ANYSKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGE 587
+ V H+ V+ ++ +++ E++ R++++ Q +QL ++D Q ++W+ +
Sbjct: 461 NKEN--VDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLD 518
Query: 588 AFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQ 647
A L H +G + L ++H F +VAQ+TY +LL+A L Q+ C
Sbjct: 519 ALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGD 578
Query: 648 AAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAV 706
+L + F E+R L+M+++FH++ +++ E + + D+ + +EAV
Sbjct: 579 TLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAV 637
Score = 90.5 bits (223), Expect = 2e-17
Identities = 99/425 (23%), Positives = 187/425 (44%), Gaps = 31/425 (7%)
Query: 501 VSQDGKSLLDKLQRPLTPGSSDSLTASANYSK--AVHHVLDVIHEVLHHQRQLENIWQHR 558
V Q G LL +LQ+ GS ++ S + A V+ ++ + + + + + R
Sbjct: 209 VLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQR 268
Query: 559 KVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQ 618
+R QL QQ V QV++W+E G L G+G S+ ++ALQ++HE+ E
Sbjct: 269 S----KRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHS 324
Query: 619 NTYTNADKLLEAAEQLAQTG-ECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFH 677
+ +L + L G E D E+ QL D ++E R+ LL ++ FH
Sbjct: 325 EWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFH 384
Query: 678 THVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQ 737
++L L+ L L DV ++Q +K ++ ++ + ++G+ L+ Q
Sbjct: 385 GVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQ 444
Query: 738 LRDSA---ISSNKTPHNS-SINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFER 793
+ + A + T N +++HI+ V++ + + + E++ R++K+ +QL E
Sbjct: 445 ISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEE 504
Query: 794 DAIDIISDLESWNDELSQ---QMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQ 850
DA + L D L + ++ D D ++ + ++ + D A + T+D G+
Sbjct: 505 DAAQAVEWLSELLDALLKTHIRLGD-DAQETKVLLEKHRKFVDVAQS----TYD---YGR 556
Query: 851 DLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLR 910
LLQ +LC + D L L+ ++ +A+E+ LE +
Sbjct: 557 QLLQ--------ATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAF- 607
Query: 911 HLQAE 915
H AE
Sbjct: 608 HSNAE 612
Score = 84.3 bits (207), Expect = 2e-15
Identities = 84/420 (20%), Positives = 181/420 (43%), Gaps = 25/420 (5%)
Query: 845 VIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLE 904
V+ G +LL + + + +G D V + +LL + + LD EQ+ ++ E
Sbjct: 209 VLQTGHELLSELQQRRFNG----SDGGVSWSPMDDELLA-QPQVMKLLDSLREQYTRYQE 263
Query: 905 QC------VQLRHLQAEVKQVLGWIRN-GESMLNAGLITASSLQEAEQLQREHEQFQHAI 957
C QL +Q +V QV+ W+ G L A S++ ++ LQ++HE+ +
Sbjct: 264 VCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQH 323
Query: 958 EKTHQSALQVQQKAEAMLQA-NHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAF 1016
+ +++ Q+ A+L A + D+ ++ ++++ + ++E R L+ A++ F
Sbjct: 324 SEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEF 383
Query: 1017 YKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTL 1076
+ ++ + L+ L + GA ++ + L+ + L+
Sbjct: 384 HGVAQDLSQQLDGLLGMLCVDVAPADGAS-------IQQTLKLLEEKLKSVDVGLQGL-- 434
Query: 1077 ARRNADVFLKYLHRNSVNMPGMVTHIKAPEQ--QVKNILNELFQRENRVLHYWTMRKRRL 1134
R L + + G I+ E ++ ++ ++ R+ R +R+ ++
Sbjct: 435 -REKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKM 493
Query: 1135 DQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKE 1194
Q Q E A QA+EW+ + + L TH G Q T+ LL++H +F A+ T +
Sbjct: 494 LQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYD 553
Query: 1195 RVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNK 1254
+ L+Q C+ + + +++ ++ F++ E+ LE A+ S++ K
Sbjct: 554 YGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEK 613
Score = 73.2 bits (178), Expect = 4e-12
Identities = 73/334 (21%), Positives = 139/334 (41%), Gaps = 39/334 (11%)
Query: 227 ATHMLSRLEELQDILAKKELPQD---LEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLL 283
A + +L+ L +L P D ++ ++EE K K + ++ L +GQ LL
Sbjct: 387 AQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEE----KLKSVDVGLQGLREKGQGLL 442
Query: 284 QRI--QSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQ 341
+I Q+S ++ K + ++ + + +++ + +Q M VR+LK+ Q Q
Sbjct: 443 DQISNQASWAYGKDVTIENKENVDH----IQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQ 498
Query: 342 LRLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRI 401
L E+DA + +W++ L ++ +G L +H F + Y ++
Sbjct: 499 LFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQL 558
Query: 402 MSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNV 461
+ L +S S+ +L + WK F A +ER L+M+ FH AEK +
Sbjct: 559 LQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQ-- 616
Query: 462 DSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLT--PG 519
D P E + + D + E+ GKSLLD+L P+ G
Sbjct: 617 ----------DCPEEPEAINDEEQ------------FDEIEAVGKSLLDRLTVPVVYPDG 654
Query: 520 SSDSLTASANYSKAVHHVLDVIHEVLHHQRQLEN 553
+ + ++ + ++ D + V ++QL +
Sbjct: 655 TEQYFGSPSDMASTAENIRDRMKLVNLKRQQLRH 688
Score = 53.5 bits (127), Expect = 3e-06
Identities = 53/278 (19%), Positives = 119/278 (42%), Gaps = 21/278 (7%)
Query: 758 ETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMN--- 814
E L +L Q Q+ ++ + +LE F ++ + + +LSQQ++
Sbjct: 346 EEDLVELKSLQQQLSDVCYRQASQLE-------FRQNLLQAALEFHGVAQDLSQQLDGLL 398
Query: 815 -----DFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQAS---GVEL 866
D D +Q L+ +K +++ + +GQ LL ++ QAS G ++
Sbjct: 399 GMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISN-QASWAYGKDV 457
Query: 867 LCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNG 926
+ ++ +Q ++E + ++Q + + R + Q VQL + + Q + W+
Sbjct: 458 TIENKENV-DHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSEL 516
Query: 927 -ESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMI 985
+++L + QE + L +H +F + T+ Q+ Q + Q+
Sbjct: 517 LDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSS 576
Query: 986 RDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQV 1023
D ++ W+Q + E+R+ + ++AF+ +E++
Sbjct: 577 GDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKI 614
Score = 35.0 bits (79), Expect = 1.2
Identities = 50/195 (25%), Positives = 84/195 (43%), Gaps = 23/195 (11%)
Query: 1106 EQQVKNILNELFQRENRVLHYWTMRKRR--LDQCQQYVVFERSAKQALEWIHDNGEFYLS 1163
+ QV +L+ L ++ R R +R L++ QQ V+ Q + W+ G L
Sbjct: 244 QPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVM------QVVNWLEGPGSEQLR 297
Query: 1164 THTSTGSSIQHTQELLKEHEEFQIT-AKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVT 1222
G SI+ +Q L ++HEE + ++ V+L Q+A E+K
Sbjct: 298 AQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQ 357
Query: 1223 AV-DKRYRDFSLRMEKYRTSLEKAL---GISSDSNKSSKSLQ----LDIIPASIPGSEVK 1274
+ D YR S ++E + L+ AL G++ D ++ L +D+ PA +
Sbjct: 358 QLSDVCYRQAS-QLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQT 416
Query: 1275 LRDAAHELNEEKRKS 1289
L+ L EEK KS
Sbjct: 417 LK-----LLEEKLKS 426
>gi|153791628 MCF.2 cell line derived transforming sequence isoform a
[Homo sapiens]
Length = 985
Score = 218 bits (554), Expect = 1e-55
Identities = 129/316 (40%), Positives = 185/316 (58%), Gaps = 21/316 (6%)
Query: 1293 KEFIMAELIQTEKAYVRDLRECMDTYLWEMTSG--VEEIPPGIVNKELIIFGNMQEIYEF 1350
K ++ ELIQTE+ YVR+L + Y EM + + +PP + NK+ I+FGNM EIYEF
Sbjct: 556 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 615
Query: 1351 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-SYFDEIQ 1409
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ ++F E Q
Sbjct: 616 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 675
Query: 1410 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGEIKDGLEVMLSVPKRANDA 1467
++ + SYL+KPVQRITKYQLLLKELL + EG +K L+ ML + K ND+
Sbjct: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 735
Query: 1468 MHLSMLEGFDENIESQGELILQESFQVW--------DPKTLIR-KGRERHLFLFEMSLVF 1518
MH + G+ N+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 736 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 795
Query: 1519 SKEVKDSSGRS----KYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKAS 1574
K +S S Y +K E+G+TE+V+GD KF +W G + +++AS
Sbjct: 796 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGE---KEEVYIVQAS 852
Query: 1575 SIENKQDWIKHIREVI 1590
+++ K W+K IR ++
Sbjct: 853 NVDVKMTWLKEIRNIL 868
Score = 194 bits (494), Expect = 9e-49
Identities = 121/341 (35%), Positives = 193/341 (56%), Gaps = 19/341 (5%)
Query: 1952 SSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKE----DGVPDD 2007
SS P ++ S + + H VL EL++TER YVR+L V+ GY A M D +P
Sbjct: 539 SSGPSSSLDNGNSLDVLKNH-VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPL 597
Query: 2008 MKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPK 2067
++ K I+FGN+ +IY++H D FL LE C PE++G F++ + MY YCQNKP+
Sbjct: 598 LRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPR 657
Query: 2068 SEHIVSEYID-TFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTS 2126
SE I +Y + FF++ +++L HRL+L L+KPVQRI KYQLLLK+ LKYSK ++
Sbjct: 658 SETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCE-GSA 716
Query: 2127 ELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLV--------TDQDAG 2178
L++A++ M + + ND M+ + G+ G + GK+++Q F V T
Sbjct: 717 LLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDL 776
Query: 2179 LLPRCRERRIFLFEQIVIF-SEPLDKKKGFS-MPGFLFKNSIKVSCLCLEENVENDPCKF 2236
+ +R +FL+E+ ++F ++ +G P + FK+ K+ + + E V+ D KF
Sbjct: 777 ARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKF 836
Query: 2237 ALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFL 2277
+ G+ E +I+ +S+ V+ TW+ EI IL Q+ L
Sbjct: 837 EIW--YGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELL 875
Score = 134 bits (337), Expect = 1e-30
Identities = 116/464 (25%), Positives = 206/464 (44%), Gaps = 27/464 (5%)
Query: 71 EKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDM 130
+ +A+LSGGR K I+TFP N I +E + ++++YL I + FT+I+D
Sbjct: 2 QDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDR 61
Query: 131 RGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTN----FGSSKFEFETNMV-- 184
R W S+K L+ + SFP +H+ L+++P +F Q+ T+ F F + +V
Sbjct: 62 RLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVML 121
Query: 185 -SLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAK 243
S+ L +D QLTPE G L+Y H EWI R A E++ M L+ LA+
Sbjct: 122 SSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAE 181
Query: 244 KELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSG-SGNA 302
ELP D+ ++ ++ + ++K I + EG+ LL ++ ++ +S +
Sbjct: 182 TELPDDIPSIEEILAIRAE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR 240
Query: 303 DLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGL 362
+ ++ +L ++H W +LK++Q QL FEQD F +
Sbjct: 241 QISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQD----FQQLVTEVEF 296
Query: 363 FLNSYTEI----GTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQ 418
LN E+ GT +++ N N + ++ ++L + HYA
Sbjct: 297 LLNQQAELADVTGTIAQVKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHYALDL 355
Query: 419 IRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSE-- 476
I Q ++L + + + ++ + +S F K K + C GE L ++
Sbjct: 356 ICQRCNEL--RYLSDILVNEIKAKRIQLSRTF--KMHKLLQQARQCCDE-GECLLANQEI 410
Query: 477 --LQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTP 518
Q EDA Q I + +A ++ + ++L + L+P
Sbjct: 411 DKFQSKEDAQKALQDIENFLEMALPFINYEPETLQYEFDVILSP 454
Score = 58.5 bits (140), Expect = 1e-07
Identities = 66/326 (20%), Positives = 140/326 (42%), Gaps = 34/326 (10%)
Query: 429 EWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQ 488
EW F A++ F ++ + S+ E +LP ++ +E+ +
Sbjct: 150 EWIIFRNAIEN----------FALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRA 199
Query: 489 GIYEHITLAYSEVSQDGKSLLDKLQRPLTPGS-SDSLTASANYS---KAVHHVLDVIHEV 544
Y + + V+++GK LL L+ P T G+ S L S + ++ +L +H++
Sbjct: 200 ERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM 259
Query: 545 LHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHR 602
+ + W+ ++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ +
Sbjct: 260 ---ETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQ 313
Query: 603 ARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFVRR 662
+ K+ E+ +E +Q + A ++ +LA + I Q ++L V
Sbjct: 314 VKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNE 373
Query: 663 VEQRKILLDMSVSFHTHVKELWTWLEE----LQKELLDDVYA--------ESVEAVQDLI 710
++ ++I L + H +++ +E L + +D + + +E ++
Sbjct: 374 IKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMA 433
Query: 711 KRFGQQQQTTLQVTVNVIKEGEDLIQ 736
F + TLQ +VI E +Q
Sbjct: 434 LPFINYEPETLQYEFDVILSPELKVQ 459
Score = 50.8 bits (120), Expect = 2e-05
Identities = 46/244 (18%), Positives = 116/244 (47%), Gaps = 18/244 (7%)
Query: 675 SFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDL 734
+F VKE+ L+ EL + + + ++++++ ++ V KEG+ L
Sbjct: 160 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 219
Query: 735 IQQLR----DSAISSNKTPHNSSINHIETV---LQQLDEAQSQMEELFQERKIKLELFLQ 787
+ L + A+SS H +T+ L Q+ + ++ + +++ ++K+E +LQ
Sbjct: 220 LTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQ 279
Query: 788 LRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIH 847
L FE+D +++++E L+QQ + D+T +++ K ++ + +++
Sbjct: 280 LWKFEQDFQQLVTEVEFL---LNQQA---ELADVTGTIAQVKQKIKKLENLDENSQELLS 333
Query: 848 QGQDLLQYVNEVQAS---GVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR--KH 902
+ Q ++ + +++ A+ ++L+C R ++ L+ + K+ +L + H+ +
Sbjct: 334 KAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQ 393
Query: 903 LEQC 906
QC
Sbjct: 394 ARQC 397
Score = 37.4 bits (85), Expect = 0.23
Identities = 42/194 (21%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 808 ELSQQMNDFDTE--------DLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEV 859
E++Q + F TE D+ E+ L A++ + N V +G+ LL +
Sbjct: 167 EMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVP 226
Query: 860 QASGV---ELLCDRDV--DMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQA 914
G L C R + D T + LL +H+ + D E+H+ +EQ +QL +
Sbjct: 227 DTEGAVSSRLECHRQISGDWQT-INKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQ 285
Query: 915 EVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQ---QKA 971
+ +Q+ + E +LN A Q++++ ++ ++ E + + + Q
Sbjct: 286 DFQQL---VTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHG 342
Query: 972 EAMLQANHYDMDMI 985
+ +HY +D+I
Sbjct: 343 HKLAANHHYALDLI 356
>gi|153791325 MCF.2 cell line derived transforming sequence isoform b
[Homo sapiens]
Length = 925
Score = 218 bits (554), Expect = 1e-55
Identities = 129/316 (40%), Positives = 185/316 (58%), Gaps = 21/316 (6%)
Query: 1293 KEFIMAELIQTEKAYVRDLRECMDTYLWEMTSG--VEEIPPGIVNKELIIFGNMQEIYEF 1350
K ++ ELIQTE+ YVR+L + Y EM + + +PP + NK+ I+FGNM EIYEF
Sbjct: 496 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 555
Query: 1351 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-SYFDEIQ 1409
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ ++F E Q
Sbjct: 556 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 615
Query: 1410 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGEIKDGLEVMLSVPKRANDA 1467
++ + SYL+KPVQRITKYQLLLKELL + EG +K L+ ML + K ND+
Sbjct: 616 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 675
Query: 1468 MHLSMLEGFDENIESQGELILQESFQVW--------DPKTLIR-KGRERHLFLFEMSLVF 1518
MH + G+ N+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 676 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 735
Query: 1519 SKEVKDSSGRS----KYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKAS 1574
K +S S Y +K E+G+TE+V+GD KF +W G + +++AS
Sbjct: 736 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGE---KEEVYIVQAS 792
Query: 1575 SIENKQDWIKHIREVI 1590
+++ K W+K IR ++
Sbjct: 793 NVDVKMTWLKEIRNIL 808
Score = 194 bits (494), Expect = 9e-49
Identities = 121/341 (35%), Positives = 193/341 (56%), Gaps = 19/341 (5%)
Query: 1952 SSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKE----DGVPDD 2007
SS P ++ S + + H VL EL++TER YVR+L V+ GY A M D +P
Sbjct: 479 SSGPSSSLDNGNSLDVLKNH-VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPL 537
Query: 2008 MKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPK 2067
++ K I+FGN+ +IY++H D FL LE C PE++G F++ + MY YCQNKP+
Sbjct: 538 LRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPR 597
Query: 2068 SEHIVSEYID-TFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTS 2126
SE I +Y + FF++ +++L HRL+L L+KPVQRI KYQLLLK+ LKYSK ++
Sbjct: 598 SETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCE-GSA 656
Query: 2127 ELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLV--------TDQDAG 2178
L++A++ M + + ND M+ + G+ G + GK+++Q F V T
Sbjct: 657 LLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDL 716
Query: 2179 LLPRCRERRIFLFEQIVIF-SEPLDKKKGFS-MPGFLFKNSIKVSCLCLEENVENDPCKF 2236
+ +R +FL+E+ ++F ++ +G P + FK+ K+ + + E V+ D KF
Sbjct: 717 ARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKF 776
Query: 2237 ALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFL 2277
+ G+ E +I+ +S+ V+ TW+ EI IL Q+ L
Sbjct: 777 EIW--YGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELL 815
Score = 88.6 bits (218), Expect = 9e-17
Identities = 89/387 (22%), Positives = 165/387 (42%), Gaps = 27/387 (6%)
Query: 148 SFPCCIHVALIIKPDNFWQKQRTNFG----SSKFEFETNMVSLEGLTKV---VDPSQLTP 200
SFP +H+ L+++P +F Q+ T+ G F + +V L ++ + +D QLTP
Sbjct: 19 SFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTP 78
Query: 201 EFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEH 260
E G L+Y H EWI R A E++ M L+ LA+ ELP D+ ++
Sbjct: 79 ELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIR 138
Query: 261 SQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSG-SGNADLQNLLPKVSTMLDRLH 319
++ + ++K I + EG+ LL ++ ++ +S + + ++ +L ++H
Sbjct: 139 AE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVH 197
Query: 320 STRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEI----GTSHP 375
W +LK++Q QL FEQD F + LN E+ GT
Sbjct: 198 DMETAFDGFWEKHQLKMEQYLQLWKFEQD----FQQLVTEVEFLLNQQAELADVTGTIAQ 253
Query: 376 HAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAA 435
+++ N N + ++ ++L + HYA I Q ++L + +
Sbjct: 254 VKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNEL--RYLSDIL 310
Query: 436 ALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSE----LQDLEDAIHHHQGIY 491
+ ++ + +S F K K + C GE L ++ Q EDA Q I
Sbjct: 311 VNEIKAKRIQLSRTF--KMHKLLQQARQCCDE-GECLLANQEIDKFQSKEDAQKALQDIE 367
Query: 492 EHITLAYSEVSQDGKSLLDKLQRPLTP 518
+ +A ++ + ++L + L+P
Sbjct: 368 NFLEMALPFINYEPETLQYEFDVILSP 394
Score = 58.5 bits (140), Expect = 1e-07
Identities = 66/326 (20%), Positives = 140/326 (42%), Gaps = 34/326 (10%)
Query: 429 EWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQ 488
EW F A++ F ++ + S+ E +LP ++ +E+ +
Sbjct: 90 EWIIFRNAIEN----------FALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRA 139
Query: 489 GIYEHITLAYSEVSQDGKSLLDKLQRPLTPGS-SDSLTASANYS---KAVHHVLDVIHEV 544
Y + + V+++GK LL L+ P T G+ S L S + ++ +L +H++
Sbjct: 140 ERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM 199
Query: 545 LHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHR 602
+ + W+ ++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ +
Sbjct: 200 ---ETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQ 253
Query: 603 ARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFVRR 662
+ K+ E+ +E +Q + A ++ +LA + I Q ++L V
Sbjct: 254 VKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNE 313
Query: 663 VEQRKILLDMSVSFHTHVKELWTWLEE----LQKELLDDVYA--------ESVEAVQDLI 710
++ ++I L + H +++ +E L + +D + + +E ++
Sbjct: 314 IKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMA 373
Query: 711 KRFGQQQQTTLQVTVNVIKEGEDLIQ 736
F + TLQ +VI E +Q
Sbjct: 374 LPFINYEPETLQYEFDVILSPELKVQ 399
Score = 50.8 bits (120), Expect = 2e-05
Identities = 46/244 (18%), Positives = 116/244 (47%), Gaps = 18/244 (7%)
Query: 675 SFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDL 734
+F VKE+ L+ EL + + + ++++++ ++ V KEG+ L
Sbjct: 100 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 159
Query: 735 IQQLR----DSAISSNKTPHNSSINHIETV---LQQLDEAQSQMEELFQERKIKLELFLQ 787
+ L + A+SS H +T+ L Q+ + ++ + +++ ++K+E +LQ
Sbjct: 160 LTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQ 219
Query: 788 LRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIH 847
L FE+D +++++E L+QQ + D+T +++ K ++ + +++
Sbjct: 220 LWKFEQDFQQLVTEVEFL---LNQQA---ELADVTGTIAQVKQKIKKLENLDENSQELLS 273
Query: 848 QGQDLLQYVNEVQAS---GVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR--KH 902
+ Q ++ + +++ A+ ++L+C R ++ L+ + K+ +L + H+ +
Sbjct: 274 KAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQ 333
Query: 903 LEQC 906
QC
Sbjct: 334 ARQC 337
Score = 37.4 bits (85), Expect = 0.23
Identities = 42/194 (21%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 808 ELSQQMNDFDTE--------DLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEV 859
E++Q + F TE D+ E+ L A++ + N V +G+ LL +
Sbjct: 107 EMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVP 166
Query: 860 QASGV---ELLCDRDV--DMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQA 914
G L C R + D T + LL +H+ + D E+H+ +EQ +QL +
Sbjct: 167 DTEGAVSSRLECHRQISGDWQT-INKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQ 225
Query: 915 EVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQ---QKA 971
+ +Q+ + E +LN A Q++++ ++ ++ E + + + Q
Sbjct: 226 DFQQL---VTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHG 282
Query: 972 EAMLQANHYDMDMI 985
+ +HY +D+I
Sbjct: 283 HKLAANHHYALDLI 296
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 204 bits (518), Expect = 1e-51
Identities = 167/574 (29%), Positives = 270/574 (47%), Gaps = 53/574 (9%)
Query: 1733 HKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRL------SS 1786
H+++ SV++ +A P A VA L+PH +G K + WL P RL S
Sbjct: 553 HQEATSVAA-EAFPGAGVAVLKPHALG-------KPWASQQDLWLQYPQTRLRLEEALSE 604
Query: 1787 GKADGHVKKLAH---KHKKSREVRKSADAGSQKDSDDS---AATPQDETVEERGR----- 1835
D + LA KH++++E + S DS A P GR
Sbjct: 605 AAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRALLCG 664
Query: 1836 --NEGLSSGTLSK----SSSSGMQSCGEEEGE-EGADAVPLPPPMAIQQHSLLQPDSQDD 1888
E L G + S G+ G E + A P + P +
Sbjct: 665 QDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQKKMI 724
Query: 1889 KASSRLLVR-----PTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFN 1943
K + + P S P + S E V S +A E + L + Q S P
Sbjct: 725 KKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLE-VTSTVATEKK---LPLWQHARSPPVTQ 780
Query: 1944 PSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDG 2003
S S P +E ++ S + RH ++ E++ TER+Y+R LGYV++ Y M+
Sbjct: 781 SRSLSSPSGLHPAEEDGRQQVGSSRLRH-IMAEMIATEREYIRCLGYVIDNYFPEMERMD 839
Query: 2004 VPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQ 2063
+P ++GK ++FGN+ +++D+H+ FL ELE+C P +G F++HE + MY+ Y +
Sbjct: 840 LPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSK 899
Query: 2064 NKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSK---K 2120
NKP+S+ ++S + + FF+D ++ LG ++ L L++PVQR+ KY LLL+D LK +
Sbjct: 900 NKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLA 959
Query: 2121 ASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLL 2180
+ EL A V+C R ND++ + ++G D + QG+L +D F+V L
Sbjct: 960 QGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYL 1019
Query: 2181 PRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFAL-T 2239
R +FLFE +++FS+ +K S +L+K S K + + + ENV + +F +
Sbjct: 1020 -----RHVFLFEDLILFSK--TQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWF 1072
Query: 2240 SRTGDVVETFILHSSSPSVRQTWIHEINQILENQ 2273
R +T+IL +SS V+ W I +IL Q
Sbjct: 1073 RRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQ 1106
Score = 192 bits (488), Expect = 4e-48
Identities = 113/324 (34%), Positives = 176/324 (54%), Gaps = 14/324 (4%)
Query: 1280 HELNEEKRKS--ARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKE 1337
H E+ R+ + R IMAE+I TE+ Y+R L +D Y EM ++P G+ K
Sbjct: 791 HPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMER--MDLPQGLRGKH 848
Query: 1338 LIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLI 1397
+IFGN++++++FH FL+ELE+ + P VG F+ ++F MYV Y KNKP S L+
Sbjct: 849 HVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALL 908
Query: 1398 LEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG------KGEIK 1451
H ++F + Q+ G ++SYL++PVQR+ KY LLL++LL G GE++
Sbjct: 909 SSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELR 968
Query: 1452 DGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFL 1511
V+ + ND + + + G D N++ QG+L ++ F V RK RH+FL
Sbjct: 969 AAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV----CCGRKKYLRHVFL 1024
Query: 1512 FEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVL 1571
FE ++FSK K YLYK T+E+G+TE+V +F +W R S + +L
Sbjct: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
Query: 1572 KASSIENKQDWIKHIREVIQERTI 1595
+ASS E K W I ++ + +
Sbjct: 1085 QASSAEVKSAWTDVIGRILWRQAL 1108
Score = 83.2 bits (204), Expect = 4e-15
Identities = 71/281 (25%), Positives = 126/281 (44%), Gaps = 27/281 (9%)
Query: 68 ILKEKVAYLSGGRDKRGGPILTFPARS---NHDRIRQEDLRRLISYLACIPSEEVCKRGF 124
+L+ V L G RD+ G ++ RS + +L RL+ Y IP +EV G
Sbjct: 197 LLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGL 256
Query: 125 TVIVDMRGSKW-DSIKPLLKILQESFPCCIH-VALIIKPDNFWQKQRTNFGSSKFEFETN 182
V+VD R S ++ L LQ + IH + L++ ++ ++ + +
Sbjct: 257 VVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEV----- 311
Query: 183 MVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILA 242
+ SL+ + K VD QLT + DG Y+H +WI R E + +N + L+ L
Sbjct: 312 VSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLN 371
Query: 243 KKELPQDLEGARNMIEEHSQLKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGN 301
P+ + +I++H + K V++ P + L LEG +L R++ E G
Sbjct: 372 THRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE--------LGT 423
Query: 302 ADLQNLLPKVSTMLDRLH--------STRQHLHQMWHVRKL 334
D ++ L +++ DR+ ++ L Q+ H+R+L
Sbjct: 424 EDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLREL 464
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 200 bits (509), Expect = 2e-50
Identities = 103/266 (38%), Positives = 161/266 (60%), Gaps = 8/266 (3%)
Query: 2793 DSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-------RDQVTHELGILQ 2845
+ FY ELG G+F++VKKC +K T A KF+ K+ + R+++ E+ IL+
Sbjct: 20 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 79
Query: 2846 SLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLEAVRY 2905
+ H ++ L D +E T +L+LE+ G L D + + SL+E + + + ++L+ V Y
Sbjct: 80 QVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNY 139
Query: 2906 LHNCRIAHLDLKPENI-LVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEII 2964
LH +IAH DLKPENI L+D+++ P IKL DFG A ++ + G PEF APEI+
Sbjct: 140 LHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV 199
Query: 2965 LGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAK 3024
P+ L +D WS+GV+TY+LLSG SPFL D+ +ET NI + + F +++F S+ AK
Sbjct: 200 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAK 259
Query: 3025 EFVCFLLQEDPAKRPSAALALQEQWL 3050
+F+ LL ++ KR + AL+ W+
Sbjct: 260 DFIRKLLVKETRKRLTIQEALRHPWI 285
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 194 bits (493), Expect = 1e-48
Identities = 111/309 (35%), Positives = 175/309 (56%), Gaps = 9/309 (2%)
Query: 1966 SLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDW 2025
SL R VL E+V TER+YVR L Y +E Y + VP ++G+ +FGN+ ++ D+
Sbjct: 648 SLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDF 707
Query: 2026 HRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQ 2085
H FFL ELE C P ++ F++H + MY Y +NKP+S+ ++S Y TFF+D +Q
Sbjct: 708 HCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQ 767
Query: 2086 RLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDM 2145
LG L L L+KP+QR+ KY LLL++ + + + S L A ++ R ND+
Sbjct: 768 ALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL 827
Query: 2146 MNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAGLLPRCRERRIFLFEQIVIFSEPLDKK 2204
+ + +QG D + QG+L+ QD F+V T + + RRIFLFE++++FS+P
Sbjct: 828 LAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV------RRIFLFEELLLFSKPRHGP 881
Query: 2205 KGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIH 2264
G + F +K S K++ L L E N +F + R +TF+L +SS +++Q W
Sbjct: 882 TG--VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 939
Query: 2265 EINQILENQ 2273
+I+ +L Q
Sbjct: 940 DISHLLWRQ 948
Score = 174 bits (442), Expect = 9e-43
Identities = 104/317 (32%), Positives = 168/317 (52%), Gaps = 16/317 (5%)
Query: 1288 KSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347
+S R + ++AE++ TE+ YVR L M+ Y E+ ++P G+ + +FGN++++
Sbjct: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 704
Query: 1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDE 1407
+FH + FL+ELE + P V + F+ +F MY Y KNKP S L+ + ++F +
Sbjct: 705 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 764
Query: 1408 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVP---KRA 1464
QQ G ++SYL+KP+QR+ KY LLL+EL C E+ E V +
Sbjct: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 824
Query: 1465 NDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRE---RHLFLFEMSLVFSKE 1521
ND + + ++G D N++ QG+L+ Q+ F ++R GR R +FLFE L+FSK
Sbjct: 825 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 877
Query: 1522 VKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQD 1581
+G + YK ++LG+TE +F +W R D VL+ASS+ KQ
Sbjct: 878 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 936
Query: 1582 WIKHIREVIQERTIHLK 1598
W I ++ + +H K
Sbjct: 937 WTADISHLLWRQAVHNK 953
Score = 50.4 bits (119), Expect = 3e-05
Identities = 64/287 (22%), Positives = 119/287 (41%), Gaps = 30/287 (10%)
Query: 69 LKEKVAYLSGGRDKRGGPILTFPARSN---HDRIRQEDLRRLISYLACIPSEEVCKRGFT 125
+ ++ G RD +G +L A S ++L RL+ YL IP EV G T
Sbjct: 109 MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 168
Query: 126 VIVDMR-GSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMV 184
V+VD R + S+ L LQE+ P ++ L++ T + +
Sbjct: 169 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLV--------GSTLLKEVPSGLQLEQL 220
Query: 185 SLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKK 244
+ L + + L G L Y H+ W++ R E + N + L+ I + K
Sbjct: 221 PSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGA--IESVK 278
Query: 245 ELPQDLEGAR--NMIEEHSQLKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGN 301
+PQ +E ++++ L ++V+ +P + L +G + L ++ + P+ +
Sbjct: 279 AVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLK--QEVPEVTL---S 333
Query: 302 ADLQNLLPKVSTMLDRLHSTRQHLHQM-----WHVRKLKLDQCFQLR 343
D + + K + DR+ LHQ+ ++ L+L Q + R
Sbjct: 334 PDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 377
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 194 bits (493), Expect = 1e-48
Identities = 111/309 (35%), Positives = 175/309 (56%), Gaps = 9/309 (2%)
Query: 1966 SLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDW 2025
SL R VL E+V TER+YVR L Y +E Y + VP ++G+ +FGN+ ++ D+
Sbjct: 729 SLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDF 788
Query: 2026 HRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQ 2085
H FFL ELE C P ++ F++H + MY Y +NKP+S+ ++S Y TFF+D +Q
Sbjct: 789 HCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQ 848
Query: 2086 RLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDM 2145
LG L L L+KP+QR+ KY LLL++ + + + S L A ++ R ND+
Sbjct: 849 ALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL 908
Query: 2146 MNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAGLLPRCRERRIFLFEQIVIFSEPLDKK 2204
+ + +QG D + QG+L+ QD F+V T + + RRIFLFE++++FS+P
Sbjct: 909 LAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV------RRIFLFEELLLFSKPRHGP 962
Query: 2205 KGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIH 2264
G + F +K S K++ L L E N +F + R +TF+L +SS +++Q W
Sbjct: 963 TG--VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 2265 EINQILENQ 2273
+I+ +L Q
Sbjct: 1021 DISHLLWRQ 1029
Score = 174 bits (442), Expect = 9e-43
Identities = 104/317 (32%), Positives = 168/317 (52%), Gaps = 16/317 (5%)
Query: 1288 KSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347
+S R + ++AE++ TE+ YVR L M+ Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDE 1407
+FH + FL+ELE + P V + F+ +F MY Y KNKP S L+ + ++F +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1408 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVP---KRA 1464
QQ G ++SYL+KP+QR+ KY LLL+EL C E+ E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1465 NDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRE---RHLFLFEMSLVFSKE 1521
ND + + ++G D N++ QG+L+ Q+ F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1522 VKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQD 1581
+G + YK ++LG+TE +F +W R D VL+ASS+ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1582 WIKHIREVIQERTIHLK 1598
W I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 55.1 bits (131), Expect = 1e-06
Identities = 80/327 (24%), Positives = 138/327 (42%), Gaps = 34/327 (10%)
Query: 31 GAGEGAEEAAKDLADIAAFFRSGFRKN-DEMKAMDVL-PILKEKVAYLSGGRDKRGGPIL 88
G G+ E +K L AA SG K D + A D+ +L +A L G RD +G +L
Sbjct: 152 GLGDPLSEISKLLE--AAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVL 209
Query: 89 TFPARSN---HDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMR-GSKWDSIKPLLKI 144
A S ++L RL+ YL IP EV G TV+VD R + S+ L
Sbjct: 210 LLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQ 269
Query: 145 LQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDG 204
LQE+ P ++ L++ T + + + L + + L G
Sbjct: 270 LQEAAPGAVYQVLLV--------GSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGG 321
Query: 205 CLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGAR--NMIEEHSQ 262
L Y H+ W++ R E + N + L+ I + K +PQ +E ++++
Sbjct: 322 GLPYCHQAWLDFRRRLEALLQNCQAACALLQGA--IESVKAVPQPMEPGEVGQLLQQTEV 379
Query: 263 LKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHST 321
L ++V+ +P + L +G + L ++ + P+ + D + + K + DR+
Sbjct: 380 LMQQVLDSPWLAWLQCQGGRELTWLK--QEVPEVTL---SPDYRTAMDKADELYDRVDGL 434
Query: 322 RQHLHQM-----WHVRKLKLDQCFQLR 343
LHQ+ ++ L+L Q + R
Sbjct: 435 ---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 194 bits (493), Expect = 1e-48
Identities = 111/309 (35%), Positives = 175/309 (56%), Gaps = 9/309 (2%)
Query: 1966 SLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDW 2025
SL R VL E+V TER+YVR L Y +E Y + VP ++G+ +FGN+ ++ D+
Sbjct: 729 SLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDF 788
Query: 2026 HRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQ 2085
H FFL ELE C P ++ F++H + MY Y +NKP+S+ ++S Y TFF+D +Q
Sbjct: 789 HCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQ 848
Query: 2086 RLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDM 2145
LG L L L+KP+QR+ KY LLL++ + + + S L A ++ R ND+
Sbjct: 849 ALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL 908
Query: 2146 MNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAGLLPRCRERRIFLFEQIVIFSEPLDKK 2204
+ + +QG D + QG+L+ QD F+V T + + RRIFLFE++++FS+P
Sbjct: 909 LAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV------RRIFLFEELLLFSKPRHGP 962
Query: 2205 KGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIH 2264
G + F +K S K++ L L E N +F + R +TF+L +SS +++Q W
Sbjct: 963 TG--VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 2265 EINQILENQ 2273
+I+ +L Q
Sbjct: 1021 DISHLLWRQ 1029
Score = 174 bits (442), Expect = 9e-43
Identities = 104/317 (32%), Positives = 168/317 (52%), Gaps = 16/317 (5%)
Query: 1288 KSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347
+S R + ++AE++ TE+ YVR L M+ Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDE 1407
+FH + FL+ELE + P V + F+ +F MY Y KNKP S L+ + ++F +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1408 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVP---KRA 1464
QQ G ++SYL+KP+QR+ KY LLL+EL C E+ E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1465 NDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRE---RHLFLFEMSLVFSKE 1521
ND + + ++G D N++ QG+L+ Q+ F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1522 VKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQD 1581
+G + YK ++LG+TE +F +W R D VL+ASS+ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1582 WIKHIREVIQERTIHLK 1598
W I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 55.1 bits (131), Expect = 1e-06
Identities = 80/327 (24%), Positives = 138/327 (42%), Gaps = 34/327 (10%)
Query: 31 GAGEGAEEAAKDLADIAAFFRSGFRKN-DEMKAMDVL-PILKEKVAYLSGGRDKRGGPIL 88
G G+ E +K L AA SG K D + A D+ +L +A L G RD +G +L
Sbjct: 152 GLGDPLSEISKLLE--AAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVL 209
Query: 89 TFPARSN---HDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMR-GSKWDSIKPLLKI 144
A S ++L RL+ YL IP EV G TV+VD R + S+ L
Sbjct: 210 LLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQ 269
Query: 145 LQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDG 204
LQE+ P ++ L++ T + + + L + + L G
Sbjct: 270 LQEAAPGAVYQVLLV--------GSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGG 321
Query: 205 CLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGAR--NMIEEHSQ 262
L Y H+ W++ R E + N + L+ I + K +PQ +E ++++
Sbjct: 322 GLPYCHQAWLDFRRRLEALLQNCQAACALLQGA--IESVKAVPQPMEPGEVGQLLQQTEV 379
Query: 263 LKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHST 321
L ++V+ +P + L +G + L ++ + P+ + D + + K + DR+
Sbjct: 380 LMQQVLDSPWLAWLQCQGGRELTWLK--QEVPEVTL---SPDYRTAMDKADELYDRVDGL 434
Query: 322 RQHLHQM-----WHVRKLKLDQCFQLR 343
LHQ+ ++ L+L Q + R
Sbjct: 435 ---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 194 bits (493), Expect = 1e-48
Identities = 111/309 (35%), Positives = 175/309 (56%), Gaps = 9/309 (2%)
Query: 1966 SLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDW 2025
SL R VL E+V TER+YVR L Y +E Y + VP ++G+ +FGN+ ++ D+
Sbjct: 729 SLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDF 788
Query: 2026 HRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQ 2085
H FFL ELE C P ++ F++H + MY Y +NKP+S+ ++S Y TFF+D +Q
Sbjct: 789 HCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQ 848
Query: 2086 RLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDM 2145
LG L L L+KP+QR+ KY LLL++ + + + S L A ++ R ND+
Sbjct: 849 ALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL 908
Query: 2146 MNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAGLLPRCRERRIFLFEQIVIFSEPLDKK 2204
+ + +QG D + QG+L+ QD F+V T + + RRIFLFE++++FS+P
Sbjct: 909 LAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV------RRIFLFEELLLFSKPRHGP 962
Query: 2205 KGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIH 2264
G + F +K S K++ L L E N +F + R +TF+L +SS +++Q W
Sbjct: 963 TG--VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 2265 EINQILENQ 2273
+I+ +L Q
Sbjct: 1021 DISHLLWRQ 1029
Score = 174 bits (442), Expect = 9e-43
Identities = 104/317 (32%), Positives = 168/317 (52%), Gaps = 16/317 (5%)
Query: 1288 KSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347
+S R + ++AE++ TE+ YVR L M+ Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDE 1407
+FH + FL+ELE + P V + F+ +F MY Y KNKP S L+ + ++F +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1408 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVP---KRA 1464
QQ G ++SYL+KP+QR+ KY LLL+EL C E+ E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1465 NDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRE---RHLFLFEMSLVFSKE 1521
ND + + ++G D N++ QG+L+ Q+ F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1522 VKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQD 1581
+G + YK ++LG+TE +F +W R D VL+ASS+ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1582 WIKHIREVIQERTIHLK 1598
W I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 55.1 bits (131), Expect = 1e-06
Identities = 80/327 (24%), Positives = 138/327 (42%), Gaps = 34/327 (10%)
Query: 31 GAGEGAEEAAKDLADIAAFFRSGFRKN-DEMKAMDVL-PILKEKVAYLSGGRDKRGGPIL 88
G G+ E +K L AA SG K D + A D+ +L +A L G RD +G +L
Sbjct: 152 GLGDPLSEISKLLE--AAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVL 209
Query: 89 TFPARSN---HDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMR-GSKWDSIKPLLKI 144
A S ++L RL+ YL IP EV G TV+VD R + S+ L
Sbjct: 210 LLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQ 269
Query: 145 LQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDG 204
LQE+ P ++ L++ T + + + L + + L G
Sbjct: 270 LQEAAPGAVYQVLLV--------GSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGG 321
Query: 205 CLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGAR--NMIEEHSQ 262
L Y H+ W++ R E + N + L+ I + K +PQ +E ++++
Sbjct: 322 GLPYCHQAWLDFRRRLEALLQNCQAACALLQGA--IESVKAVPQPMEPGEVGQLLQQTEV 379
Query: 263 LKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHST 321
L ++V+ +P + L +G + L ++ + P+ + D + + K + DR+
Sbjct: 380 LMQQVLDSPWLAWLQCQGGRELTWLK--QEVPEVTL---SPDYRTAMDKADELYDRVDGL 434
Query: 322 RQHLHQM-----WHVRKLKLDQCFQLR 343
LHQ+ ++ L+L Q + R
Sbjct: 435 ---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 194 bits (493), Expect = 1e-48
Identities = 111/309 (35%), Positives = 175/309 (56%), Gaps = 9/309 (2%)
Query: 1966 SLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDW 2025
SL R VL E+V TER+YVR L Y +E Y + VP ++G+ +FGN+ ++ D+
Sbjct: 729 SLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDF 788
Query: 2026 HRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQ 2085
H FFL ELE C P ++ F++H + MY Y +NKP+S+ ++S Y TFF+D +Q
Sbjct: 789 HCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQ 848
Query: 2086 RLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDM 2145
LG L L L+KP+QR+ KY LLL++ + + + S L A ++ R ND+
Sbjct: 849 ALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL 908
Query: 2146 MNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAGLLPRCRERRIFLFEQIVIFSEPLDKK 2204
+ + +QG D + QG+L+ QD F+V T + + RRIFLFE++++FS+P
Sbjct: 909 LAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV------RRIFLFEELLLFSKPRHGP 962
Query: 2205 KGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIH 2264
G + F +K S K++ L L E N +F + R +TF+L +SS +++Q W
Sbjct: 963 TG--VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 2265 EINQILENQ 2273
+I+ +L Q
Sbjct: 1021 DISHLLWRQ 1029
Score = 174 bits (442), Expect = 9e-43
Identities = 104/317 (32%), Positives = 168/317 (52%), Gaps = 16/317 (5%)
Query: 1288 KSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347
+S R + ++AE++ TE+ YVR L M+ Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDE 1407
+FH + FL+ELE + P V + F+ +F MY Y KNKP S L+ + ++F +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1408 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVP---KRA 1464
QQ G ++SYL+KP+QR+ KY LLL+EL C E+ E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1465 NDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRE---RHLFLFEMSLVFSKE 1521
ND + + ++G D N++ QG+L+ Q+ F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1522 VKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQD 1581
+G + YK ++LG+TE +F +W R D VL+ASS+ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1582 WIKHIREVIQERTIHLK 1598
W I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 55.1 bits (131), Expect = 1e-06
Identities = 80/327 (24%), Positives = 138/327 (42%), Gaps = 34/327 (10%)
Query: 31 GAGEGAEEAAKDLADIAAFFRSGFRKN-DEMKAMDVL-PILKEKVAYLSGGRDKRGGPIL 88
G G+ E +K L AA SG K D + A D+ +L +A L G RD +G +L
Sbjct: 152 GLGDPLSEISKLLE--AAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVL 209
Query: 89 TFPARSN---HDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMR-GSKWDSIKPLLKI 144
A S ++L RL+ YL IP EV G TV+VD R + S+ L
Sbjct: 210 LLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQ 269
Query: 145 LQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDG 204
LQE+ P ++ L++ T + + + L + + L G
Sbjct: 270 LQEAAPGAVYQVLLV--------GSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGG 321
Query: 205 CLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGAR--NMIEEHSQ 262
L Y H+ W++ R E + N + L+ I + K +PQ +E ++++
Sbjct: 322 GLPYCHQAWLDFRRRLEALLQNCQAACALLQGA--IESVKAVPQPMEPGEVGQLLQQTEV 379
Query: 263 LKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHST 321
L ++V+ +P + L +G + L ++ + P+ + D + + K + DR+
Sbjct: 380 LMQQVLDSPWLAWLQCQGGRELTWLK--QEVPEVTL---SPDYRTAMDKADELYDRVDGL 434
Query: 322 RQHLHQM-----WHVRKLKLDQCFQLR 343
LHQ+ ++ L+L Q + R
Sbjct: 435 ---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 188 bits (477), Expect = 8e-47
Identities = 125/407 (30%), Positives = 204/407 (50%), Gaps = 28/407 (6%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATL 2744
P F + +V GET V G+P I W E L H S Y + E +L
Sbjct: 1485 PRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEV-LLTESSHVSFVYEE-NECSL 1542
Query: 2745 KIVGVTTEDDGIYTCIAVNDMGSASSSASL---------RVLGPGMDGIMVTWKDN---- 2791
++ +D G+YTC A N G S A L V G G D +D+
Sbjct: 1543 VVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVHSAQTAMEVEGVGED------EDHRGRR 1596
Query: 2792 FDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQSLQHPL 2851
FY E+GRG FS +++ ++ + A KF+ + + E +L LQH
Sbjct: 1597 LSDFYDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDC 1656
Query: 2852 LVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRI 2911
++ + FE ++V E+ + LL+ + R ++ E +IRA++ +VLE + YLH +
Sbjct: 1657 VLYFHEAFERRRGLVIVTELCTE-ELLERIARKPTVCESEIRAYMRQVLEGIHYLHQSHV 1715
Query: 2912 AHLDLKPENILV-DESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVS 2970
HLD+KPEN+LV D + + +++ DFG+A +L + G PEF APEI+ +PVS
Sbjct: 1716 LHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVS 1775
Query: 2971 LTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFL 3030
+D W VGV+ ++ L+G+SPF+ ++ T +NI + +F + F +S++A+ F+ +
Sbjct: 1776 GVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKV 1835
Query: 3031 LQEDPAKRPSAALALQEQWLQAGNGRSTGV-LDTSRLTSFIERRKHQ 3076
L +D RP+A L+ W + ++ G + T L F+ RR+ Q
Sbjct: 1836 LVQD-RLRPTAEETLEHPWFKT---QAKGAEVSTDHLKLFLSRRRWQ 1878
Score = 134 bits (337), Expect = 1e-30
Identities = 88/287 (30%), Positives = 136/287 (47%), Gaps = 10/287 (3%)
Query: 2796 YSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGL 2855
Y+ + E RGRF VV+ C + T R K V + +V E +L++L H ++ L
Sbjct: 2966 YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSL 3025
Query: 2856 LDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLD 2915
+ + TP +L+ E LL + +E + ++ ++L+ + YLH + HLD
Sbjct: 3026 HEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHLD 3085
Query: 2916 LKPENILVDESLAKPTIKLADFGDAVQLNTTYY--IHQLLGNPEFAAPEIILGNPVSLTS 2973
+KP+N+L+ A +K+ DFG A N + G EF APE++ G P+ +
Sbjct: 3086 IKPDNLLLAPDNA---LKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSAT 3142
Query: 2974 DTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQE 3033
D W GVLTY++LSG SPF + +ET I F + SQ A F+ +L
Sbjct: 3143 DIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFD-AFQLYPNTSQSATLFLRKVLSV 3201
Query: 3034 DPAKRPSAALALQEQWLQAGN----GRSTGVLDTSRLTSFIERRKHQ 3076
P RPS L WLQ R T T+RL F+ ++ +
Sbjct: 3202 HPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRR 3248
Score = 49.7 bits (117), Expect = 5e-05
Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 2684 PPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEAT 2743
PP F + L + + G+ V++ RV G PK ++W + D ++ G
Sbjct: 868 PPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWL-RNRQPVRPDQRRFAEEAEGGLCR 926
Query: 2744 LKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
L+I+ D G YTC AVN+ G+ A L V
Sbjct: 927 LRILAAERGDAGFYTCKAVNEYGARQCEARLEV 959
Score = 45.8 bits (107), Expect = 7e-04
Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 2/92 (2%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATL 2744
P+F+ PL ++ + +L C+V G P +I+W H ++D Y D+
Sbjct: 1188 PDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVF 1247
Query: 2745 KIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
VG + G+Y + N +G A+ A L V
Sbjct: 1248 PAVG--PQHAGVYKSVIANKLGKAACYAHLYV 1277
Score = 45.1 bits (105), Expect = 0.001
Identities = 40/158 (25%), Positives = 70/158 (44%), Gaps = 8/158 (5%)
Query: 2625 TLKKSTSWHTA-LRLRKKSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIY-- 2681
TL+K+ + A RLR+ E+ G + + K R ++ + +Y+
Sbjct: 656 TLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGARSQGKGRRARPTSPELESSDDSYVSAG 715
Query: 2682 DVP---PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSD 2738
+ P P F IPL V G V+L+C + P ++W + + L ++G + ++
Sbjct: 716 EEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWH-KDGSALRSEGRLLLR-AE 773
Query: 2739 LGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
TL + D G Y A N++G A+ +ASL V
Sbjct: 774 GERHTLLLREARAADAGSYMATATNELGQATCAASLTV 811
Score = 42.7 bits (99), Expect = 0.006
Identities = 28/95 (29%), Positives = 39/95 (41%), Gaps = 1/95 (1%)
Query: 2682 DVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGE 2741
D PP F I L + GE L C P I+W + + + +S D G
Sbjct: 2581 DFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKD-GR 2639
Query: 2742 ATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
L I G+Y C A N +GS +SS ++ V
Sbjct: 2640 QLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAV 2674
Score = 42.0 bits (97), Expect = 0.009
Identities = 32/102 (31%), Positives = 42/102 (41%), Gaps = 16/102 (15%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITW-------KGPEHNTLNNDGHYSISYS 2737
P F L +V G C++ G P +TW + E+ L DG
Sbjct: 1064 PLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDG------- 1116
Query: 2738 DLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779
G +L I V +ED+G+Y AVN G A SA L V P
Sbjct: 1117 --GLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEP 1156
Score = 41.6 bits (96), Expect = 0.012
Identities = 47/164 (28%), Positives = 67/164 (40%), Gaps = 38/164 (23%)
Query: 2381 AAPEAGPSAPSRRPP-----GADAEGSEREAEPIPKMKVLESPRKGAANASGSS---PDA 2432
A PE RRPP + ++ E E E +P + PR SGS D
Sbjct: 1899 APPERVWVTMPRRPPPSGGLSSSSDSEEEELEELPSV-----PRPLQPEFSGSRVSLTDI 1953
Query: 2433 PAKDARASLGTLPLGKPRAGAASPLN-------------SPLSSAVPSLGKEPFPPSSP- 2478
P +D LG P GAA+P++ +P A+PS G+EP +SP
Sbjct: 1954 PTEDEA-------LGTPETGAATPMDWQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPR 2006
Query: 2479 ---LQKGGSFWSSIPASPASRPGSFTFPGDSDSL-QRQTPRHAA 2518
L++G S S++P + G S L QR++P A
Sbjct: 2007 RGELRRGSSAESALPRAGPRELGRGLHKAASVELPQRRSPSPGA 2050
Score = 38.5 bits (88), Expect = 0.10
Identities = 30/96 (31%), Positives = 42/96 (43%), Gaps = 9/96 (9%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATL 2744
P F+ PL G V LR V G P+ S+ W DG + + + L
Sbjct: 43 PVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWF--------RDGQLLPAPAP-EPSCL 93
Query: 2745 KIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGPG 2780
+ +D G+Y+C+A N+ G AS A L VL G
Sbjct: 94 WLRRCGAQDAGVYSCMAQNERGRASCEAVLTVLEVG 129
Score = 35.4 bits (80), Expect = 0.88
Identities = 34/128 (26%), Positives = 46/128 (35%), Gaps = 8/128 (6%)
Query: 2329 GAPSTSRSRPSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPS 2388
G P + R R Q R P L S+ + + T TP P+ P G P + S
Sbjct: 2839 GPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPASTPQGVKPVSS-S 2897
Query: 2389 APS-------RRPPGADAEGSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASL 2441
P PP + E EP SP K ++ GSSP + + +L
Sbjct: 2898 TPVYVVTSFVSAPPAPEPPAPEPPPEPTKVTVQSLSPAKEVVSSPGSSPRSSPRPEGTTL 2957
Query: 2442 GTLPLGKP 2449
P KP
Sbjct: 2958 RQGPPQKP 2965
Score = 34.7 bits (78), Expect = 1.5
Identities = 38/162 (23%), Positives = 55/162 (33%), Gaps = 29/162 (17%)
Query: 2354 SSAASSQAEADKMSGTSTPGPSLP----PPGAAPEAGPSAPSRRPPGADAEGSEREAEPI 2409
S +A S+A+ + S P PS P P P P P+ +P A + E EP+
Sbjct: 2166 SLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQP--AQDKAPEPRPEPV 2223
Query: 2410 PKMKVLESPR---------------------KGAANASGSSPDAPAKDARASLGTLP-LG 2447
K P+ G A P AP + + +
Sbjct: 2224 RASKPAPPPQALQTLALPLTPYAQIIQSLQLSGHAQGPSQGPAAPPSEPKPHAAVFARVA 2283
Query: 2448 KPRAGAASPLNSPLSSAVPSLGKEPFPPSSPLQKGGSFWSSI 2489
P GA P + P L ++ P+ P + G S SSI
Sbjct: 2284 SPPPGAPEK-RVPSAGGPPVLAEKARVPTVPPRPGSSLSSSI 2324
Score = 33.5 bits (75), Expect = 3.4
Identities = 55/210 (26%), Positives = 72/210 (34%), Gaps = 26/210 (12%)
Query: 2323 GPSSCGGAPSTSRSRPSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLP--PPG 2380
G PS + +P R PP +S A A A + T PS P PP
Sbjct: 2770 GTQDSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPLAPAAPTPPSVTVSPSSPPTPPS 2829
Query: 2381 AAPEA------GPSAPSRRPPGADAEGSEREAEP-IPKMKVLESPRKGAANASGSSPDAP 2433
A + P P RR G A R AEP +P V S K +G+ A
Sbjct: 2830 QALSSLKAVGPPPQTPPRRHRGLQA---ARPAEPTLPSTHVTPSEPKPFVLDTGTPIPA- 2885
Query: 2434 AKDARASLGTLPLGKPRAGAASPLNSPLS-SAVPSLGKEPFPPSSPLQKGGSFWSSIPAS 2492
+ P G +++P+ S + P + P P P + S PA
Sbjct: 2886 ---------STPQGVKPVSSSTPVYVVTSFVSAPPAPEPPAPEPPPEPTKVTVQSLSPAK 2936
Query: 2493 P-ASRPGSFTFPGDSDSLQRQTPRHAAPGK 2521
S PGS P S + T R P K
Sbjct: 2937 EVVSSPGS--SPRSSPRPEGTTLRQGPPQK 2964
Score = 32.3 bits (72), Expect = 7.5
Identities = 62/240 (25%), Positives = 85/240 (35%), Gaps = 36/240 (15%)
Query: 2341 IPQP-VRHHPPVLVSSAASSQAEADKMSGTSTPGPS--LPPPGAAPEAG---PSAPSRRP 2394
+PQ +R P L AS EA + P S LPPP +P G P P +P
Sbjct: 274 VPQSGLRREEPDLQPQLAS---EAPRRPAQPPPSKSALLPPP--SPRVGKRSPPGPPAQP 328
Query: 2395 PGADAEGSEREAEPI-PKMKVLESPRKGAANASG--------SSPDAPAKDARASLGTLP 2445
R EP+ P+ E R + +SG S P P +A L L
Sbjct: 329 AATPTSPHRRTQEPVLPEDTTTEEKRGKKSKSSGPSLAGTAESRPQTPLSEASGRLSALG 388
Query: 2446 LGKPRAGAASPLNSPL---SSAVPSLGKEPFPPSS-----PLQKGGSFW--SSIPASPAS 2495
A S + L SL + PP+ PL+K S S +P
Sbjct: 389 RSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSERGAPWG 448
Query: 2496 RPGS----FTFPGDSDSLQRQTPRHAAPGKDTDRMSTCSSASEQSVQSTQSNGSESSSSS 2551
PG+ PG +R + AA + R S AS+ ++ Q G S+S
Sbjct: 449 TPGASQEELRAPGSVAERRRLFQQKAASLDERTRQR--SPASDLELRFAQELGRIRRSTS 506
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 186 bits (472), Expect = 3e-46
Identities = 98/256 (38%), Positives = 161/256 (62%), Gaps = 6/256 (2%)
Query: 2801 ELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRD---QVTHELGILQSLQ-HPLLVGLL 2856
ELGRG+F+VV+KC +K + + A KF+ K+ +D ++ HE+ +L+ Q +P ++ L
Sbjct: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
Query: 2857 DTFETPTSYILVLEMADQGRLLD-CVV-RWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHL 2914
+ +ET + ILVLE A G + D CV R + E ++ + ++LE V +LH + HL
Sbjct: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
Query: 2915 DLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSD 2974
DLKP+NIL+ IK+ DFG + L + + +++G PE+ APEI+ +P+S+ +D
Sbjct: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
Query: 2975 TWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQED 3034
WS+GVLTYV+L+G+SPFL + +ET LNI +++ S+ ++ F +S+ A +F+ LL +
Sbjct: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
Query: 3035 PAKRPSAALALQEQWL 3050
P R +A L+ WL
Sbjct: 306 PEDRATAEECLKHPWL 321
>gi|4758194 serine/threonine kinase 17B [Homo sapiens]
Length = 372
Score = 181 bits (460), Expect = 8e-45
Identities = 94/269 (34%), Positives = 163/269 (60%), Gaps = 7/269 (2%)
Query: 2790 DNFDSFYSEVA-ELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRD---QVTHELGILQ 2845
+NF++FY + ELGRG+F+VV++C K T + A KF+ K+ +D ++ HE+ +L+
Sbjct: 26 ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLE 85
Query: 2846 SLQH-PLLVGLLDTFETPTSYILVLEMADQGRLLD-CVVRWGSL-TEGKIRAHLGEVLEA 2902
+ P ++ L + +E + IL+LE A G + C+ + +E + + ++LE
Sbjct: 86 LAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEG 145
Query: 2903 VRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPE 2962
V YLH I HLDLKP+NIL+ IK+ DFG + ++ + +++G PE+ APE
Sbjct: 146 VYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE 205
Query: 2963 IILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQK 3022
I+ +P++ +D W++G++ Y+LL+ SPF+ + +ET LNI +++ + ++ F VSQ
Sbjct: 206 ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQL 265
Query: 3023 AKEFVCFLLQEDPAKRPSAALALQEQWLQ 3051
A +F+ LL ++P KRP+A + L WLQ
Sbjct: 266 ATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 181 bits (460), Expect = 8e-45
Identities = 179/682 (26%), Positives = 292/682 (42%), Gaps = 97/682 (14%)
Query: 60 MKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEV 119
+ A++++ L + A LSGGR + G PI+TFP S I ED +++YL IPS E
Sbjct: 36 LMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEA 95
Query: 120 CKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKF-- 177
GF V++D R KW S+K L + +FP + + I++P F Q+ T+ G +
Sbjct: 96 ASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRN 155
Query: 178 EFETNMV-----SLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLS 232
EF+T + S+ L +D SQLT E G LEY H +W+ R A E++
Sbjct: 156 EFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQ 215
Query: 233 RLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESF 292
L+ LA ELP+ + +++ H++ + K ++ ++ L +G LL IQ
Sbjct: 216 MLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDK-LQDELKLLGKQGTTLLSCIQE---- 270
Query: 293 PKKNSGSGNADLQNLLPKVSTM---LDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQD- 348
P + +L N L V+TM L +L T + W LKL+QC QL+ FE D
Sbjct: 271 PATKCPNSKLNL-NQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDF 329
Query: 349 --AEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVAN 406
A+ D + + +T IG S H ++ +H + V +
Sbjct: 330 CKAKLALDNLLEEQA----EFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGD 385
Query: 407 RLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCK 466
+L++S HYA+ IR +L F ++ +L S FH++ +K V WC+
Sbjct: 386 QLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDK----VSQWCE 441
Query: 467 ACGEVDLPSELQD-----------LEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRP 515
A G L S+ D L D + E+ L+ E + + LL
Sbjct: 442 A-GIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLL------ 494
Query: 516 LTPGSSDSLTASANYSKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQ-QD 574
+L A A K + LD + E+ H R+V L ++L Q +
Sbjct: 495 -------TLDAKAKAQKVLQR-LDDVQEIFH----------KRQVSL---MKLAAKQTRP 533
Query: 575 VQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQL 634
VQ V E+ + SK + S+ AR L+ E + E N+ D +
Sbjct: 534 VQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKF---- 589
Query: 635 AQTGECDPEEIYQAAH-------QLEDRIQDFVRRVEQRKILLDMSVSFHTHVKEL---- 683
E EEI+++ H + + R+ D R R+I+ D+ + ++KE+
Sbjct: 590 ----EVKSEEIFESHHERGNPELEQQARLGDLSPR---RRIIRDLLETEEIYIKEIKSII 642
Query: 684 --------WTWLEELQKELLDD 697
+ WL+ L ++L +
Sbjct: 643 DGYITPMDFIWLKHLIPDVLQN 664
Score = 151 bits (381), Expect = 1e-35
Identities = 108/377 (28%), Positives = 188/377 (49%), Gaps = 43/377 (11%)
Query: 1960 EERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMK----EDGVPDDMKGKDKIV 2015
++ + L R ++++L+ETE Y++++ +++GY+ M + +PD ++ +
Sbjct: 610 QQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFL 669
Query: 2016 FGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEY 2075
FGNI ++Y++H FL ELEKC E+PE L F+K + L +Y Y +N P++ I E
Sbjct: 670 FGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQEC 729
Query: 2076 ID-TFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSK--------------- 2119
D +F +++L H L L L P QR++KYQ+LLK L +
Sbjct: 730 QDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSA 789
Query: 2120 -------KASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLV 2172
K S ++EL++A+ V+ + + C +++ + I GKLLL F V
Sbjct: 790 KDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSV 849
Query: 2173 --TDQDAGLLP-----RCRERRIFLFEQIVIF----SEPLDKKKGFSMPGFLFKNSIKVS 2221
+D + + +R+I+LFE+ ++F EP D +G S P + FK ++K+
Sbjct: 850 WTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGD--QGLS-PHYSFKKTMKLM 906
Query: 2222 CLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNALT 2281
L + + KF + SR G +E +IL ++S +R W EI+++L Q+N +
Sbjct: 907 TLSIRQLGRGSHRKFEIASRNG--LEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQG 964
Query: 2282 SPIEYQRNHSGGGGGGG 2298
+P G G G G
Sbjct: 965 NPQFEMSTSKGSGAGSG 981
Score = 127 bits (319), Expect = 2e-28
Identities = 117/419 (27%), Positives = 189/419 (45%), Gaps = 64/419 (15%)
Query: 1281 ELNEEKRK---SARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE--IPPGIVN 1335
EL ++ R S RR+ I+ +L++TE+ Y+++++ +D Y+ M + IP + N
Sbjct: 607 ELEQQARLGDLSPRRR--IIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQN 664
Query: 1336 KELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQ 1395
+ +FGN++E+YEFHN FLKELEK + PE + HCF+ + Q+Y Y KN P +
Sbjct: 665 NKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARA 724
Query: 1396 LILE-HAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTC-------CEEGK 1447
+ E +YF Q++ + YL P QR+ KYQ+LLK LL + G+
Sbjct: 725 IWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGE 784
Query: 1448 --GEIKDG----------------LEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQ 1489
G KDG L V+ + K A+ L+ + ++I G+L+L
Sbjct: 785 LGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLH 844
Query: 1490 ESFQVW-------DPKTLIR-KGRERHLFLFEMSLVFSK---EVKDSSGRSKYLYKSKLF 1538
F VW K LIR K +R ++LFE +VF K E D Y +K +
Sbjct: 845 GPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMK 904
Query: 1539 TSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLK 1598
L + + G KF + + K +L+A+S E + W I +++ E+ ++K
Sbjct: 905 LMTLSIRQLGRGSHRKFEI---ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIK 961
Query: 1599 GALKEPIHIPKTAPATRQKGRRDGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGG 1657
+G E S+G G+ I R + + D +GG
Sbjct: 962 -----------------DQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGG 1003
Score = 58.2 bits (139), Expect = 1e-07
Identities = 40/170 (23%), Positives = 77/170 (45%), Gaps = 12/170 (7%)
Query: 1059 MISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNMPGMVTHIKAPEQ--QVKNILNEL 1116
++ H Q++ L + L + + P ++ E ++ +L +L
Sbjct: 239 LLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQL 298
Query: 1117 FQRENRVLHYWTMRKRRLDQCQQYVVFERS---AKQALE-WIHDNGEFYLSTHTSTGSSI 1172
+ E H+W+ +L+QC Q FE AK AL+ + + EF T G S+
Sbjct: 299 DETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEF-----TGIGDSV 353
Query: 1173 QHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIK-KCV 1221
H +++LKEH++ + +++ E+ +LL + D + H A I+ +CV
Sbjct: 354 MHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCV 403
Score = 43.5 bits (101), Expect = 0.003
Identities = 44/226 (19%), Positives = 93/226 (41%), Gaps = 15/226 (6%)
Query: 808 ELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELL 867
EL + M TEDL ++ R + L + QG LL + E
Sbjct: 228 ELPRSM--LSTEDLLMSHTRQRDKLQDELKLLG------KQGTTLLSCIQEPATKCPNSK 279
Query: 868 CD-RDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQ---AEVKQVLGWI 923
+ ++ T ++ LL L E ++ +H L QC+QL+H + + K L +
Sbjct: 280 LNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNL 339
Query: 924 RNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMD 983
++ S+ EQ+ +EH++ + ++ + A + + ++Q++HY D
Sbjct: 340 LEEQAEFTG---IGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAAD 396
Query: 984 MIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLES 1029
IR ++ + + + ++ S+ F++ ++V E+
Sbjct: 397 AIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEA 442
Score = 37.7 bits (86), Expect = 0.18
Identities = 46/210 (21%), Positives = 91/210 (43%), Gaps = 17/210 (8%)
Query: 702 SVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQLRDSAISSNKTPHN----SSINHI 757
S+ + +DL+ +Q+ + K+G L+ +++ A + N ++ +
Sbjct: 232 SMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTM 291
Query: 758 ETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFD 817
E +L QLDE + + E +KL LQL+ FE D L++ +E ++ D
Sbjct: 292 ERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGD 351
Query: 818 T----EDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQ----YVNEVQASGVEL--L 867
+ E + ++L+ + + L L V G L+Q + ++ VEL L
Sbjct: 352 SVMHVEQILKEHKKLEEKSQEPLEKAQLLALV---GDQLIQSHHYAADAIRPRCVELRHL 408
Query: 868 CDRDVDMATRVQDLLEFLHEKQQELDLAAE 897
CD ++ + D+L E ++LD ++
Sbjct: 409 CDDFINGNKKKWDILGKSLEFHRQLDKVSQ 438
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 177 bits (448), Expect = 2e-43
Identities = 102/305 (33%), Positives = 155/305 (50%), Gaps = 4/305 (1%)
Query: 2784 IMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-RDQVTHELG 2842
+ + + FY LG G+F V + +K T++ A KF K ++ + E+
Sbjct: 1452 VTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEIS 1511
Query: 2843 ILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWG-SLTEGKIRAHLGEVLE 2901
I+ L HP LV +D FE + ++VLE+ G L + ++ LTE + ++ ++ E
Sbjct: 1512 IMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISE 1571
Query: 2902 AVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAP 2961
V Y+H I HLDLKPENI+ IKL DFG A +L + L G PEF AP
Sbjct: 1572 GVEYIHKQGIVHLDLKPENIMCVNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEFVAP 1630
Query: 2962 EIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQ 3021
E+I P+ +D WS+GV+ Y+L+SG+SPF+ D+ ET N+ + F D+ F +S
Sbjct: 1631 EVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISD 1690
Query: 3022 KAKEFVCFLLQEDPAKRPSAALALQEQWLQAG-NGRSTGVLDTSRLTSFIERRKHQNDVR 3080
AK+F+ LL++D R LQ WL L R+ ++ RRK Q
Sbjct: 1691 DAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGN 1750
Query: 3081 PIRSI 3085
+R+I
Sbjct: 1751 AVRAI 1755
Score = 63.9 bits (154), Expect = 2e-09
Identities = 37/103 (35%), Positives = 54/103 (52%), Gaps = 4/103 (3%)
Query: 2677 PNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITW-KGPEHNTLNNDGHYSIS 2735
P+ + PP+F L V + G+ C++ GRP+ +TW KG + L S+S
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKG--NVPLQPSARVSVS 210
Query: 2736 YSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
+ G L+I GV +D G+YTC+ VN G AS SA L + G
Sbjct: 211 EKN-GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG 252
Score = 52.4 bits (124), Expect = 7e-06
Identities = 35/98 (35%), Positives = 45/98 (45%), Gaps = 7/98 (7%)
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDG-HYSISYSD 2738
+ +V P F L + G+ VL+C V G P ITW LN Y+ S +
Sbjct: 509 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITW------LLNGQPIQYARSTCE 562
Query: 2739 LGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
G A L I ED G YTC+A N +G S SA + V
Sbjct: 563 AGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV 600
Score = 51.6 bits (122), Expect = 1e-05
Identities = 28/94 (29%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEA 2742
V P F + ++ G C++ G P + W + ++ H+ I Y + G
Sbjct: 1807 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF-KDDQSIRESRHFQIDYDEDGNC 1865
Query: 2743 TLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
+L I V +DD YTC AVN +G A+ +A L V
Sbjct: 1866 SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1899
Score = 48.5 bits (114), Expect = 1e-04
Identities = 41/161 (25%), Positives = 66/161 (40%), Gaps = 7/161 (4%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATL 2744
P+F + +TV RC V G PK + W +G + Y D G L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEV-YEDAGSHYL 472
Query: 2745 KIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGR 2804
++ T D G Y+C A N G S S +L+V + + +F S + A +
Sbjct: 473 CLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEV----APSFSSVLKDCAVIEG 528
Query: 2805 GRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQ 2845
F V +C +GT T +N + ++ + T E G+ +
Sbjct: 529 QDF--VLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAE 567
Score = 46.6 bits (109), Expect = 4e-04
Identities = 43/161 (26%), Positives = 64/161 (39%), Gaps = 34/161 (21%)
Query: 2622 PDGTLKKSTSWHTALRLRKKSEKKDKDGKR--EGKLENGYRKSREGLSNKVSVKLLNPNY 2679
PD LK ++ KK K D + KR G +N R +G +
Sbjct: 1055 PDENLKSASKEEL-----KKDVKNDVNCKRGHAGTTDNEKRSESQGTA------------ 1097
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDL 2739
P F L +V G+ ++L+C+V P A+I W TLN + + L
Sbjct: 1098 -----PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIW------TLNGKTLKTTKFIIL 1146
Query: 2740 GE----ATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
+ ++ I ED G+Y C+A ND G A S + V
Sbjct: 1147 SQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTV 1187
Score = 46.2 bits (108), Expect = 5e-04
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 5/108 (4%)
Query: 2675 LNPNYIYDVP----PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDG 2730
++P+ + +P P F++P + + G T RV G P+ +TW + + G
Sbjct: 19 VDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWH-RNGQPITSGG 77
Query: 2731 HYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
+ + G +L I V ED G YTC A N G+ + L V G
Sbjct: 78 RFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG 125
Score = 38.5 bits (88), Expect = 0.10
Identities = 29/96 (30%), Positives = 39/96 (40%), Gaps = 4/96 (4%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLG-EAT 2743
P F+ LS++ G V + +V G P + W HN + G + +
Sbjct: 623 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWL---HNGNEIQESEDFHFEQRGTQHS 679
Query: 2744 LKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779
L I V ED G YTC A N G + A L V P
Sbjct: 680 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP 715
Score = 35.8 bits (81), Expect = 0.68
Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 1/90 (1%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATL 2744
P F+ VT G++V++ C + G P ++ W + GH+ + ++ TL
Sbjct: 721 PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNE-DVFTL 779
Query: 2745 KIVGVTTEDDGIYTCIAVNDMGSASSSASL 2774
+ V G Y + N +G S SL
Sbjct: 780 VLKKVQPWHAGQYEILLKNRVGECSCQVSL 809
Score = 35.0 bits (79), Expect = 1.2
Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 2/95 (2%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEA 2742
+PP+ + + GE+V L +V G + TW + H + S+ G +
Sbjct: 1236 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWM-KFRKQIQESEHMKVENSENG-S 1293
Query: 2743 TLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVL 2777
L I+ E G YT + N +GS + +L V+
Sbjct: 1294 KLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVV 1328
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 177 bits (448), Expect = 2e-43
Identities = 102/305 (33%), Positives = 155/305 (50%), Gaps = 4/305 (1%)
Query: 2784 IMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-RDQVTHELG 2842
+ + + FY LG G+F V + +K T++ A KF K ++ + E+
Sbjct: 1383 VTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEIS 1442
Query: 2843 ILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWG-SLTEGKIRAHLGEVLE 2901
I+ L HP LV +D FE + ++VLE+ G L + ++ LTE + ++ ++ E
Sbjct: 1443 IMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISE 1502
Query: 2902 AVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAP 2961
V Y+H I HLDLKPENI+ IKL DFG A +L + L G PEF AP
Sbjct: 1503 GVEYIHKQGIVHLDLKPENIMCVNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEFVAP 1561
Query: 2962 EIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQ 3021
E+I P+ +D WS+GV+ Y+L+SG+SPF+ D+ ET N+ + F D+ F +S
Sbjct: 1562 EVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISD 1621
Query: 3022 KAKEFVCFLLQEDPAKRPSAALALQEQWLQAG-NGRSTGVLDTSRLTSFIERRKHQNDVR 3080
AK+F+ LL++D R LQ WL L R+ ++ RRK Q
Sbjct: 1622 DAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGN 1681
Query: 3081 PIRSI 3085
+R+I
Sbjct: 1682 AVRAI 1686
Score = 63.9 bits (154), Expect = 2e-09
Identities = 37/103 (35%), Positives = 54/103 (52%), Gaps = 4/103 (3%)
Query: 2677 PNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITW-KGPEHNTLNNDGHYSIS 2735
P+ + PP+F L V + G+ C++ GRP+ +TW KG + L S+S
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKG--NVPLQPSARVSVS 210
Query: 2736 YSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
+ G L+I GV +D G+YTC+ VN G AS SA L + G
Sbjct: 211 EKN-GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG 252
Score = 52.4 bits (124), Expect = 7e-06
Identities = 35/98 (35%), Positives = 45/98 (45%), Gaps = 7/98 (7%)
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDG-HYSISYSD 2738
+ +V P F L + G+ VL+C V G P ITW LN Y+ S +
Sbjct: 440 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITW------LLNGQPIQYARSTCE 493
Query: 2739 LGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
G A L I ED G YTC+A N +G S SA + V
Sbjct: 494 AGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV 531
Score = 51.6 bits (122), Expect = 1e-05
Identities = 28/94 (29%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEA 2742
V P F + ++ G C++ G P + W + ++ H+ I Y + G
Sbjct: 1738 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF-KDDQSIRESRHFQIDYDEDGNC 1796
Query: 2743 TLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
+L I V +DD YTC AVN +G A+ +A L V
Sbjct: 1797 SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1830
Score = 46.6 bits (109), Expect = 4e-04
Identities = 43/161 (26%), Positives = 64/161 (39%), Gaps = 34/161 (21%)
Query: 2622 PDGTLKKSTSWHTALRLRKKSEKKDKDGKR--EGKLENGYRKSREGLSNKVSVKLLNPNY 2679
PD LK ++ KK K D + KR G +N R +G +
Sbjct: 986 PDENLKSASKEEL-----KKDVKNDVNCKRGHAGTTDNEKRSESQGTA------------ 1028
Query: 2680 IYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDL 2739
P F L +V G+ ++L+C+V P A+I W TLN + + L
Sbjct: 1029 -----PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIW------TLNGKTLKTTKFIIL 1077
Query: 2740 GE----ATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRV 2776
+ ++ I ED G+Y C+A ND G A S + V
Sbjct: 1078 SQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTV 1118
Score = 46.2 bits (108), Expect = 5e-04
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 5/108 (4%)
Query: 2675 LNPNYIYDVP----PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDG 2730
++P+ + +P P F++P + + G T RV G P+ +TW + + G
Sbjct: 19 VDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWH-RNGQPITSGG 77
Query: 2731 HYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
+ + G +L I V ED G YTC A N G+ + L V G
Sbjct: 78 RFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG 125
Score = 38.5 bits (88), Expect = 0.10
Identities = 29/96 (30%), Positives = 39/96 (40%), Gaps = 4/96 (4%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLG-EAT 2743
P F+ LS++ G V + +V G P + W HN + G + +
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWL---HNGNEIQESEDFHFEQRGTQHS 610
Query: 2744 LKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779
L I V ED G YTC A N G + A L V P
Sbjct: 611 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP 646
Score = 35.8 bits (81), Expect = 0.68
Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 1/90 (1%)
Query: 2685 PEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATL 2744
P F+ VT G++V++ C + G P ++ W + GH+ + ++ TL
Sbjct: 652 PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNE-DVFTL 710
Query: 2745 KIVGVTTEDDGIYTCIAVNDMGSASSSASL 2774
+ V G Y + N +G S SL
Sbjct: 711 VLKKVQPWHAGQYEILLKNRVGECSCQVSL 740
Score = 35.0 bits (79), Expect = 1.2
Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 2/95 (2%)
Query: 2683 VPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEA 2742
+PP+ + + GE+V L +V G + TW + H + S+ G +
Sbjct: 1167 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWM-KFRKQIQESEHMKVENSENG-S 1224
Query: 2743 TLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVL 2777
L I+ E G YT + N +GS + +L V+
Sbjct: 1225 KLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVV 1259
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 174 bits (441), Expect = 1e-42
Identities = 115/326 (35%), Positives = 170/326 (52%), Gaps = 12/326 (3%)
Query: 2767 SASSSASLRV-LGPGMDGIMVTW------KDNFDSFYSEVAELGRGRFSVVKKCDQKGTK 2819
SASS +S+ PG ++ + +D F+ +ELGRG S+V +C QKGT+
Sbjct: 10 SASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQ 69
Query: 2820 RAVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLD 2879
+ A K V KK + + V E+G+L L HP ++ L + FETPT LVLE+ G L D
Sbjct: 70 KPYALK-VLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFD 128
Query: 2880 CVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGD 2939
+V G +E + ++LEAV YLH I H DLKPEN+L +K+ADFG
Sbjct: 129 RIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGL 188
Query: 2940 AVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEE 2999
+ + + + G P + APEI+ G D WSVG++TY+LL G PF D+ ++
Sbjct: 189 SKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQ 248
Query: 3000 TCL-NICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRST 3058
I ++ F ++ VS AK+ V L+ DP KR + ALQ W+ G +
Sbjct: 249 FMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV-TGKAANF 307
Query: 3059 GVLDTS--RLTSFIERRKHQNDVRPI 3082
+DT+ +L F RRK + V+ +
Sbjct: 308 VHMDTAQKKLQEFNARRKLKAAVKAV 333
>gi|167466233 myosin light chain kinase family, member 4 [Homo
sapiens]
Length = 388
Score = 174 bits (440), Expect = 2e-42
Identities = 103/262 (39%), Positives = 153/262 (58%), Gaps = 5/262 (1%)
Query: 2793 DSFY--SEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-RDQVTHELGILQSLQH 2849
+SFY S+ LG GRF V KC++ T +A K + + MK +++V +E+ ++ L H
Sbjct: 101 NSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDH 160
Query: 2850 PLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWG-SLTEGKIRAHLGEVLEAVRYLHN 2908
L+ L D FE+ +LV+E D G L D ++ +LTE + ++ E +R++H
Sbjct: 161 ANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQ 220
Query: 2909 CRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNP 2968
I HLDLKPENIL AK IK+ DFG A + + G PEF APE++ +
Sbjct: 221 MYILHLDLKPENILCVNRDAKQ-IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDF 279
Query: 2969 VSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVC 3028
VS +D WSVGV+ Y+LLSG+SPFL D+ ET NI + D+ F+ +S++AKEF+
Sbjct: 280 VSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFIS 339
Query: 3029 FLLQEDPAKRPSAALALQEQWL 3050
LL ++ + R SA+ AL+ WL
Sbjct: 340 KLLIKEKSWRISASEALKHPWL 361
>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
Length = 819
Score = 166 bits (420), Expect = 3e-40
Identities = 102/251 (40%), Positives = 139/251 (55%), Gaps = 3/251 (1%)
Query: 2802 LGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-RDQVTHELGILQSLQHPLLVGLLDTFE 2860
LG GRF V +C +K T +A K + K K R+ V +E+ I+ L H L+ L D FE
Sbjct: 521 LGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFE 580
Query: 2861 TPTSYILVLEMADQGRLLDCVV-RWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPE 2919
+ S LV+E D G L D + LTE + ++ E V YLH I HLDLKPE
Sbjct: 581 SKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPE 640
Query: 2920 NILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVG 2979
NIL IK+ DFG A + + G PEF APE++ VS +D WSVG
Sbjct: 641 NILCVNQTGHQ-IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVG 699
Query: 2980 VLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRP 3039
V+TY+LLSG+SPFL ++ ET I + F D F+G+S++AK+FV LL ++ + R
Sbjct: 700 VITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRM 759
Query: 3040 SAALALQEQWL 3050
SA L+ +WL
Sbjct: 760 SATQCLKHEWL 770
Score = 32.0 bits (71), Expect = 9.8
Identities = 60/270 (22%), Positives = 87/270 (32%), Gaps = 32/270 (11%)
Query: 2311 GGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIPQPVRHHPPVLVSSAASSQAEA--DKMSG 2368
GG P SG S P + + PP+ S + A+A G
Sbjct: 168 GGKPKHVLSTSGVQSDAR-EPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQG 226
Query: 2369 TSTPGPSLPPPGAAPEAGPSAPSRRPPGADAEG--SEREAEPIPKMKVLESPRKGAANAS 2426
PGP+ PG P P+ + P +E + E P P + SP A +
Sbjct: 227 DGVPGPAQAFPGHLPL--PTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGA 284
Query: 2427 GSSPDAPAKDAR-ASLGTLPLGKPRAGAASPLNSPLSSAVPSLGKEPFP----------- 2474
G + D GT P P P + G E P
Sbjct: 285 GQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDT 344
Query: 2475 PSSPLQKG-GSFWSSI--PASPASRPGSFTFPGDSDSLQ-------RQTPRHAAPGKDTD 2524
P L G GS ++ A A++PG PG LQ QTP A ++
Sbjct: 345 PGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGA---RELS 401
Query: 2525 RMSTCSSASEQSVQSTQSNGSESSSSSNIS 2554
+ SS + Q G+E + +++
Sbjct: 402 PLQESSSPGGVKAEEEQRAGAEPGTRPSLA 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 122,303,947
Number of Sequences: 37866
Number of extensions: 6142103
Number of successful extensions: 82727
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1154
Number of HSP's successfully gapped in prelim test: 2323
Number of HSP's that attempted gapping in prelim test: 37896
Number of HSP's gapped (non-prelim): 27736
length of query: 3097
length of database: 18,247,518
effective HSP length: 121
effective length of query: 2976
effective length of database: 13,665,732
effective search space: 40669218432
effective search space used: 40669218432
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.