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Search of human proteins with 4506581
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506581 retinitis pigmentosa GTPase regulator isoform A
[Homo sapiens]
(815 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 1642 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 1289 0.0
gi|7657152 hect domain and RLD 3 [Homo sapiens] 162 2e-39
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 154 2e-37
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 154 2e-37
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 149 1e-35
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 140 4e-33
gi|61563742 hect domain and RLD 6 [Homo sapiens] 139 1e-32
gi|4557445 regulator of chromosome condensation and BTB domain c... 139 1e-32
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 136 9e-32
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 136 9e-32
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 136 9e-32
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 136 9e-32
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 136 9e-32
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 131 2e-30
gi|126032348 hect domain and RLD 2 [Homo sapiens] 129 1e-29
gi|110825982 hect domain and RLD 5 [Homo sapiens] 120 7e-27
gi|6912330 deafness locus associated putative guanine nucleotide... 119 1e-26
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 118 3e-26
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 113 6e-25
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 97 5e-20
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 97 5e-20
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 82 2e-15
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 77 5e-14
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 77 5e-14
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 74 4e-13
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 74 4e-13
gi|209364523 alsin isoform 2 [Homo sapiens] 74 7e-13
gi|40316935 alsin isoform 1 [Homo sapiens] 74 7e-13
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 68 4e-11
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 1642 bits (4252), Expect = 0.0
Identities = 815/815 (100%), Positives = 815/815 (100%)
Query: 1 MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG
Sbjct: 1 MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG
Sbjct: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV
Sbjct: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
Query: 181 CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE 240
CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE
Sbjct: 181 CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE 240
Query: 241 IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI
Sbjct: 241 IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
Query: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH
Sbjct: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Query: 361 MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD 420
MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD
Sbjct: 361 MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD 420
Query: 421 SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK 480
SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK
Sbjct: 421 SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK 480
Query: 481 EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE 540
EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE
Sbjct: 481 EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE 540
Query: 541 NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG 600
NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG
Sbjct: 541 NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG 600
Query: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVE 660
IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVE
Sbjct: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVE 660
Query: 661 SKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYML 720
SKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYML
Sbjct: 661 SKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYML 720
Query: 721 DDADSSSLEILENSETTPSKDMKKTKKIFLFKRVPSINQKIVKNNNEPLPEIKSIGDQII 780
DDADSSSLEILENSETTPSKDMKKTKKIFLFKRVPSINQKIVKNNNEPLPEIKSIGDQII
Sbjct: 721 DDADSSSLEILENSETTPSKDMKKTKKIFLFKRVPSINQKIVKNNNEPLPEIKSIGDQII 780
Query: 781 LKSDNKDADQNHMSQNHQNIPPTNTERRSKSCTIL 815
LKSDNKDADQNHMSQNHQNIPPTNTERRSKSCTIL
Sbjct: 781 LKSDNKDADQNHMSQNHQNIPPTNTERRSKSCTIL 815
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 1289 bits (3336), Expect = 0.0
Identities = 650/709 (91%), Positives = 657/709 (92%), Gaps = 27/709 (3%)
Query: 1 MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG
Sbjct: 1 MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG
Sbjct: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV
Sbjct: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
Query: 181 CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE 240
CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE
Sbjct: 181 CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE 240
Query: 241 IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI
Sbjct: 241 IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
Query: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH
Sbjct: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Query: 361 MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD 420
MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD
Sbjct: 361 MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD 420
Query: 421 SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK 480
SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK
Sbjct: 421 SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK 480
Query: 481 EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE 540
EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE
Sbjct: 481 EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE 540
Query: 541 NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG 600
NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG
Sbjct: 541 NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG 600
Query: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVE 660
IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAE E
Sbjct: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVS----------------------E 638
Query: 661 SKKKTVGDDESVPTGYHSKT-----EGAERTNDDSSAETIEKKEKANLE 704
K K+VG+ E P G T GAE D+ + + K + +E
Sbjct: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEME 687
Score = 45.8 bits (107), Expect = 2e-04
Identities = 60/249 (24%), Positives = 108/249 (43%), Gaps = 21/249 (8%)
Query: 469 EEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSL---NSNEKSLKLSPVQKQKK 525
E+ + L D++T +AE+ +S+GE D + +S + + +K +K
Sbjct: 621 EKTEILSDDLTDKAEVSEGKA-KSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEK 679
Query: 526 QQTIGELTQ----DTALTENDD----SDEYEEMSEMKEG--KACKQHVSQGIFMTQPATT 575
+ GE+ + + L E ++ E +E E ++G K Q + +G +
Sbjct: 680 DKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEG-GEEEHGEG 738
Query: 576 IEAFSDEEVEIPEEKEGAEDSKGNGIE-EQEVEANEENVKVHGGRKEKTEILSDDLTDKA 634
E D E E +E EG E+ +G +E E+E E E + G++EK E D +
Sbjct: 739 EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE 798
Query: 635 EDHEFSKTEELKLEDVD----EEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDS 690
E+ E E+ + +V+ EE E E +++ G++E G + EG E +
Sbjct: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEE-GEGEEEEGEGEEEEGEGK 857
Query: 691 SAETIEKKE 699
E E+ E
Sbjct: 858 GEEEGEEGE 866
Score = 44.3 bits (103), Expect = 5e-04
Identities = 57/234 (24%), Positives = 96/234 (41%), Gaps = 17/234 (7%)
Query: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD 581
+++ ++ GE ++ E ++ E E E EG+ ++ +G E +
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927
Query: 582 EEVEIPEEKEGA---EDSKGNGIEEQ-EVEANEENVKVHGGRKEKTEILSDDLTDKAEDH 637
E E EE+EG ED +G G EE+ E E EE + G + + E + + E+
Sbjct: 928 GEGE-GEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG 986
Query: 638 EFSKTEELKLEDVDEEINAENV---ESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAET 694
E EE E+ +EE E E +++ G+ E G + EG E ++ E
Sbjct: 987 EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE- 1045
Query: 695 IEKKEKANLEERAICEYNENPKGYMLDDADSSSLEILENSETTPSKDMKKTKKI 748
+KE E R E E +G + + E +E ++ KK KI
Sbjct: 1046 -REKEGEGEENRRNREEEEEEEGKYQETGE-------EENERQDGEEYKKVSKI 1091
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/184 (24%), Positives = 75/184 (40%), Gaps = 5/184 (2%)
Query: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS- 580
++++++ GE ++ E + E EE KE +A K+ + E
Sbjct: 745 REEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGR 804
Query: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFS 640
EE E E EG E +G G E+E E E + G +E+ E ++ K E+
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE---- 860
Query: 641 KTEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEK 700
+ EE + E+ EE E E + + G++E G + EG + E E + K
Sbjct: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920
Query: 701 ANLE 704
E
Sbjct: 921 GEEE 924
Score = 42.0 bits (97), Expect = 0.002
Identities = 48/197 (24%), Positives = 86/197 (43%), Gaps = 17/197 (8%)
Query: 508 LNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSD--EYEEMSEMKEGKACKQHVSQ 565
+ +NE+++K+ +K+K + +LT ++E E E+ E + C++ S
Sbjct: 606 VEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSG 665
Query: 566 GIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEI 625
E + DEE E E+ +G + + G E+E+ EE K G +E+ E
Sbjct: 666 A----------EHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKER 715
Query: 626 LSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVESKK---KTVGDDESVPTGYHSKTEG 682
++ ++ E EE E +EE + E E K+ K G+ E V G K EG
Sbjct: 716 EQGHQKERNQEMEEGGEEE-HGEGEEEEGDREEEEEKEGEGKEEGEGEEV-EGEREKEEG 773
Query: 683 AERTNDDSSAETIEKKE 699
+ + + E ++E
Sbjct: 774 ERKKEERAGKEEKGEEE 790
Score = 38.1 bits (87), Expect = 0.033
Identities = 38/136 (27%), Positives = 62/136 (45%), Gaps = 12/136 (8%)
Query: 583 EVEIPEEKEGAEDSKGNGIEEQ--EVEANEENVKVHG-GRKEKTEILSDDLTDKAE---- 635
E E EE EG E+ +G G EE+ EVE E + G G +E+ E ++ + E
Sbjct: 996 EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEEN 1055
Query: 636 --DHEFSKTEELKLEDVDEEIN-AENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSA 692
+ E + EE K ++ EE N ++ E KK SV G H + TN +
Sbjct: 1056 RRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNG 1115
Query: 693 ETIEKKEKANLEERAI 708
+ E++ K ++ + +
Sbjct: 1116 K--EQRSKMPVQSKRL 1129
Score = 33.5 bits (75), Expect = 0.81
Identities = 44/170 (25%), Positives = 70/170 (41%), Gaps = 22/170 (12%)
Query: 540 ENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEK---EGAEDS 596
E + E EE E EG+ ++ +G E + E E EE+ EG E+
Sbjct: 860 EEGEEGEGEEEGEEGEGEG-EEEEGEG----------EGEEEGEGEGEEEEGEGEGEEEG 908
Query: 597 KGNGIEEQ-EVEANEENVKVHG-GRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEI 654
+G G EE+ E + EE + G G +E+ E +D + E+ EE + E +EE
Sbjct: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEE------EEGEWEGEEEEG 962
Query: 655 NAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLE 704
E E + + E + EG E ++ E E +E+ E
Sbjct: 963 EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE 1012
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 162 bits (409), Expect = 2e-39
Identities = 112/361 (31%), Positives = 186/361 (51%), Gaps = 24/361 (6%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
++CG HS + + ++Y G N GQLG + +KP + AL + + ACG +H+
Sbjct: 39 VACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREG--NKPEQIGALADQHIIHVACGESHS 96
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159
L ++ G +++ G ++GQLGL TE+ + ++ I Q+S G+ AL DG
Sbjct: 97 LALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADG 156
Query: 160 RLFMWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216
+ F WG NS GQ+GL K + PQ+V G P++ ++ G HS ++ G ++ +G
Sbjct: 157 QFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGM 216
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQL 274
G+LGL ++ + +P V + +KV+ ++CG EHT VLT++ V+TFG G GQL
Sbjct: 217 NNAGQLGLSDEK--DRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQL 274
Query: 275 GLGTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGRHGKLGLG--- 330
G + E + +V+E + ++ I+CG HT A + GL+Y FG G G+LG G
Sbjct: 275 GHDSMNDEVNPRRVLE-LMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTC 333
Query: 331 -------LENFTNHFIPTLCSNFLRF---IVKLVACGGCHMVVFAAPHRGVAKEIEFDEI 380
++ + L + RF IVK + GG V + + + ++F +
Sbjct: 334 NVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTM 393
Query: 381 N 381
N
Sbjct: 394 N 394
Score = 150 bits (380), Expect = 4e-36
Identities = 102/313 (32%), Positives = 158/313 (50%), Gaps = 19/313 (6%)
Query: 64 WGQLGLGS-------KSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNE 116
WG LG + +++P + VK ACG NH++ E G VY G N +
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 117 GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176
GQLG E N I +H I ++ G + S AL++ G+LF WG S+GQ+GL
Sbjct: 64 GQLG--HEREGNKPEQIGALADQHII-HVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
Query: 177 VSN-VCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHR 233
+ V VP+ Q + + +SCG +H + DG+ + +G+ +G+LGL + +
Sbjct: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEF-PSQA 179
Query: 234 TPQLVSEIPE-KVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIEN 291
+PQ V + + QVA GG H+ L+ AV+ +G+ GQLGL + P ++
Sbjct: 180 SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEK-DRESPCHVKL 238
Query: 292 IRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIV 351
+R Q + YISCGE HTA++T G ++TFG G G+ LG ++ + P + V
Sbjct: 239 LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQ--LGHDSMNDEVNPRRVLELMGSEV 296
Query: 352 KLVACGGCHMVVF 364
+ACG H + F
Sbjct: 297 TQIACGRQHTLAF 309
Score = 126 bits (317), Expect = 7e-29
Identities = 78/246 (31%), Positives = 129/246 (52%), Gaps = 8/246 (3%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGL-GSKSAISKPTCVKALKPEKVKLAACGR 96
+H++CG+ HS ++ +L+ +G+ + GQLGL ++ +++ P ++ L + + +CG
Sbjct: 87 IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGN 146
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
H L G + G N+ GQLGLG + Q++AG S AL+
Sbjct: 147 WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALS 206
Query: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVF 214
G +F WG N+ GQ+GL + + P V + + V +ISCG H+A +T G ++ F
Sbjct: 207 LSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTF 266
Query: 215 GEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTV--VLTENAVYTFGLGQF 271
G G+LG + + + P+ V E+ +V Q+ACG +HT+ V + +Y FG G
Sbjct: 267 GAGSCGQLG--HDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGAR 324
Query: 272 GQLGLG 277
GQLG G
Sbjct: 325 GQLGTG 330
Score = 102 bits (253), Expect = 2e-21
Identities = 65/205 (31%), Positives = 103/205 (50%), Gaps = 9/205 (4%)
Query: 161 LFMWGDNSEGQIGLK-NVSNVCVPQQVT---IGKPVSWISCGYYHSAFVTTDGELYVFGE 216
+ WG S GQ G+ N+ + QV + V ++CG HS F+ DGE+Y G
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQLG 275
G+LG + ++ Q+ + + +I VACG H++ L++ ++++G G GQLG
Sbjct: 61 NTKGQLGHERE---GNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117
Query: 276 LGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFT 335
L T + P++I+ + QTI +SCG H + G +T+G HG+LGLG E F
Sbjct: 118 LMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-FP 176
Query: 336 NHFIPTLCSNFLRFIVKLVACGGCH 360
+ P + + VA GG H
Sbjct: 177 SQASPQRVRSLEGIPLAQVAAGGAH 201
Score = 81.3 bits (199), Expect = 3e-15
Identities = 56/188 (29%), Positives = 88/188 (46%), Gaps = 15/188 (7%)
Query: 12 GAVFTFGKSKFAENNPGKFWFKNDVP-----------VHLSCGDEHSAVVTGNNKLYMFG 60
G FT+GK+ + GK + P ++ G HS ++ + ++ +G
Sbjct: 156 GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 215
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
NN GQLGL + P VK L+ +KV +CG HT V T+ G V+ G + GQLG
Sbjct: 216 MNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG 275
Query: 121 LGD-TEERNTFHVISFFTSEHKIKQLSAG-SNTSAALTEDGRLFMWGDNSEGQIGLKNVS 178
+E N V+ SE + Q++ G +T A + G ++ +G + GQ+G +
Sbjct: 276 HDSMNDEVNPRRVLELMGSE--VTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTC 333
Query: 179 NVCVPQQV 186
NV P V
Sbjct: 334 NVKCPSPV 341
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 154 bits (390), Expect = 2e-37
Identities = 102/299 (34%), Positives = 161/299 (53%), Gaps = 15/299 (5%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
+ CG H+ V + +Y G N+ GQ LG + + KP V AL + + +CG HT
Sbjct: 39 VGCGLRHTVFVLDDGTVYTCGCNDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHT 96
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEE--RNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
L + G VYA G +++GQLGL +EE R ++ S S+ +I Q++ G S AL++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSK 154
Query: 158 DGRLFMWGDNSEGQIGL-KNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVF 214
+F WG N GQ+GL + PQ + +G P ++ G HS +T G ++ +
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 215 GEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272
G + G+LGL ++ + P L+ + +K++ + CG +HT LT E V+TFG G +G
Sbjct: 215 GRNKFGQLGLNDE--NDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272
Query: 273 QLGLGTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGRHGKLGLG 330
QLG + E + KV E + ++ I+CG HT A + G +Y+FG G +G+LG G
Sbjct: 273 QLGHNSTSHEINPRKVFE-LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
Score = 151 bits (382), Expect = 2e-36
Identities = 102/313 (32%), Positives = 164/313 (52%), Gaps = 14/313 (4%)
Query: 59 FGSNNWGQLGLGS--KSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNE 116
+G+ ++GQLGLG + + +P ++V+ CG HT+ + G VY G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 117 GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176
GQLG + + V++ I +S G + AL + G+++ WG +S+GQ+GL
Sbjct: 64 GQLG-HEKSRKKPEQVVAL--DAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 177 VSN-VCVPQQVTIGKPVS--WISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHR 233
+ VP+ + + ++CGYYHS ++ E++ +G+ + G+LGL
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 234 TPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENI 292
L S + +QVA GG H+ VLT A++ +G +FGQLGL + P +++++
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN-DRYVPNLLKSL 239
Query: 293 RDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFI-PTLCSNFLRFIV 351
R Q I YI CGE+HTA +T G ++TFG G +G+LG N T+H I P + IV
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG---HNSTSHEINPRKVFELMGSIV 296
Query: 352 KLVACGGCHMVVF 364
+ACG H F
Sbjct: 297 TEIACGRQHTSAF 309
Score = 130 bits (327), Expect = 5e-30
Identities = 89/283 (31%), Positives = 143/283 (50%), Gaps = 16/283 (5%)
Query: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVHL--------SCGDEHSAVVTGNNKLYMFGS 61
D G V+T G + + K K + V L SCG+ H+ + ++Y +G
Sbjct: 51 DDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
Query: 62 NNWGQLGL-GSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
++ GQLGL GS+ I P +K+L ++ ACG H+L ++ V+ G N GQLG
Sbjct: 111 DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
LG ++ T + Q++AG S LT G +F WG N GQ+GL + ++
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 181 CVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV 238
VP + + + +I CG H+A +T +G ++ FG G+LG + + P+ V
Sbjct: 231 YVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG--HNSTSHEINPRKV 288
Query: 239 SEIPEKVI-QVACGGEHT--VVLTENAVYTFGLGQFGQLGLGT 278
E+ ++ ++ACG +HT V + +Y+FGLG GQLG G+
Sbjct: 289 FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331
Score = 92.4 bits (228), Expect = 1e-18
Identities = 62/208 (29%), Positives = 98/208 (47%), Gaps = 9/208 (4%)
Query: 161 LFMWGDNSEGQIGLKNVSNVCV----PQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGE 216
+ WG+ S GQ+GL + V I K V + CG H+ FV DG +Y G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQLG 275
+ G+LG + Q+V+ + ++ V+CG HT+ L + VY +GL GQLG
Sbjct: 61 NDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Query: 276 LGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFT 335
L P+ I+++ D I ++CG H+ ++ ++ +G ++G+LGLG +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD-CK 176
Query: 336 NHFIPTLCSNFLRFIVKLVACGGCHMVV 363
P L + L VA GG H V
Sbjct: 177 KQTSPQLLKSLLGIPFMQVAAGGAHSFV 204
Score = 79.3 bits (194), Expect = 1e-14
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 21/182 (11%)
Query: 14 VFTFGKSKFAENNPGKFWFKNDVP-----------VHLSCGDEHSAVVTGNNKLYMFGSN 62
VF +G++K+ + G K P + ++ G HS V+T + ++ +G N
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 217
Query: 63 NWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLG 122
+GQLGL ++ P +K+L+ +K+ CG +HT T+ G V+ G GQLG
Sbjct: 218 KFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 123 DTEE----RNTFHVISFFTSEHKIKQLSAG-SNTSAALTEDGRLFMWGDNSEGQIGLKNV 177
T R F ++ +E ++ G +TSA + GR++ +G GQ+G +
Sbjct: 278 STSHEINPRKVFELMGSIVTE-----IACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332
Query: 178 SN 179
SN
Sbjct: 333 SN 334
Score = 69.3 bits (168), Expect = 1e-11
Identities = 43/130 (33%), Positives = 64/130 (49%), Gaps = 11/130 (8%)
Query: 11 SGAVFTFGKSKFAE---NNPGKFWFKNDVP-------VHLSCGDEHSAVVTGNNKLYMFG 60
SGA+F +G++KF + N+ + N + V++ CG++H+A +T ++ FG
Sbjct: 208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFG 267
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVST-EGGNVYATGGNNEGQL 119
+ +GQLG S S P V L V ACGR HT G +Y+ G GQL
Sbjct: 268 AGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQL 327
Query: 120 GLGDTEERNT 129
G G T R +
Sbjct: 328 GTGSTSNRKS 337
Score = 44.7 bits (104), Expect = 4e-04
Identities = 30/82 (36%), Positives = 38/82 (46%), Gaps = 11/82 (13%)
Query: 12 GAVFTFGKSKFA---------ENNPGK-FWFKNDVPVHLSCGDEH-SAVVTGNNKLYMFG 60
G VFTFG + E NP K F + ++CG +H SA V + ++Y FG
Sbjct: 261 GGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320
Query: 61 SNNWGQLGLGSKSAISKPTCVK 82
GQLG GS S P VK
Sbjct: 321 LGGNGQLGTGSTSNRKSPFTVK 342
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 154 bits (390), Expect = 2e-37
Identities = 102/299 (34%), Positives = 161/299 (53%), Gaps = 15/299 (5%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
+ CG H+ V + +Y G N+ GQ LG + + KP V AL + + +CG HT
Sbjct: 39 VGCGLRHTVFVLDDGTVYTCGCNDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHT 96
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEE--RNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
L + G VYA G +++GQLGL +EE R ++ S S+ +I Q++ G S AL++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSK 154
Query: 158 DGRLFMWGDNSEGQIGL-KNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVF 214
+F WG N GQ+GL + PQ + +G P ++ G HS +T G ++ +
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 215 GEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272
G + G+LGL ++ + P L+ + +K++ + CG +HT LT E V+TFG G +G
Sbjct: 215 GRNKFGQLGLNDE--NDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272
Query: 273 QLGLGTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGRHGKLGLG 330
QLG + E + KV E + ++ I+CG HT A + G +Y+FG G +G+LG G
Sbjct: 273 QLGHNSTSHEINPRKVFE-LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
Score = 151 bits (382), Expect = 2e-36
Identities = 102/313 (32%), Positives = 164/313 (52%), Gaps = 14/313 (4%)
Query: 59 FGSNNWGQLGLGS--KSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNE 116
+G+ ++GQLGLG + + +P ++V+ CG HT+ + G VY G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 117 GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176
GQLG + + V++ I +S G + AL + G+++ WG +S+GQ+GL
Sbjct: 64 GQLG-HEKSRKKPEQVVAL--DAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 177 VSN-VCVPQQVTIGKPVS--WISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHR 233
+ VP+ + + ++CGYYHS ++ E++ +G+ + G+LGL
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 234 TPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENI 292
L S + +QVA GG H+ VLT A++ +G +FGQLGL + P +++++
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN-DRYVPNLLKSL 239
Query: 293 RDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFI-PTLCSNFLRFIV 351
R Q I YI CGE+HTA +T G ++TFG G +G+LG N T+H I P + IV
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG---HNSTSHEINPRKVFELMGSIV 296
Query: 352 KLVACGGCHMVVF 364
+ACG H F
Sbjct: 297 TEIACGRQHTSAF 309
Score = 130 bits (327), Expect = 5e-30
Identities = 89/283 (31%), Positives = 143/283 (50%), Gaps = 16/283 (5%)
Query: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVHL--------SCGDEHSAVVTGNNKLYMFGS 61
D G V+T G + + K K + V L SCG+ H+ + ++Y +G
Sbjct: 51 DDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
Query: 62 NNWGQLGL-GSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
++ GQLGL GS+ I P +K+L ++ ACG H+L ++ V+ G N GQLG
Sbjct: 111 DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
LG ++ T + Q++AG S LT G +F WG N GQ+GL + ++
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 181 CVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV 238
VP + + + +I CG H+A +T +G ++ FG G+LG + + P+ V
Sbjct: 231 YVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG--HNSTSHEINPRKV 288
Query: 239 SEIPEKVI-QVACGGEHT--VVLTENAVYTFGLGQFGQLGLGT 278
E+ ++ ++ACG +HT V + +Y+FGLG GQLG G+
Sbjct: 289 FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331
Score = 92.4 bits (228), Expect = 1e-18
Identities = 62/208 (29%), Positives = 98/208 (47%), Gaps = 9/208 (4%)
Query: 161 LFMWGDNSEGQIGLKNVSNVCV----PQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGE 216
+ WG+ S GQ+GL + V I K V + CG H+ FV DG +Y G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQLG 275
+ G+LG + Q+V+ + ++ V+CG HT+ L + VY +GL GQLG
Sbjct: 61 NDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Query: 276 LGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFT 335
L P+ I+++ D I ++CG H+ ++ ++ +G ++G+LGLG +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD-CK 176
Query: 336 NHFIPTLCSNFLRFIVKLVACGGCHMVV 363
P L + L VA GG H V
Sbjct: 177 KQTSPQLLKSLLGIPFMQVAAGGAHSFV 204
Score = 79.3 bits (194), Expect = 1e-14
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 21/182 (11%)
Query: 14 VFTFGKSKFAENNPGKFWFKNDVP-----------VHLSCGDEHSAVVTGNNKLYMFGSN 62
VF +G++K+ + G K P + ++ G HS V+T + ++ +G N
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 217
Query: 63 NWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLG 122
+GQLGL ++ P +K+L+ +K+ CG +HT T+ G V+ G GQLG
Sbjct: 218 KFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 123 DTEE----RNTFHVISFFTSEHKIKQLSAG-SNTSAALTEDGRLFMWGDNSEGQIGLKNV 177
T R F ++ +E ++ G +TSA + GR++ +G GQ+G +
Sbjct: 278 STSHEINPRKVFELMGSIVTE-----IACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332
Query: 178 SN 179
SN
Sbjct: 333 SN 334
Score = 69.3 bits (168), Expect = 1e-11
Identities = 43/130 (33%), Positives = 64/130 (49%), Gaps = 11/130 (8%)
Query: 11 SGAVFTFGKSKFAE---NNPGKFWFKNDVP-------VHLSCGDEHSAVVTGNNKLYMFG 60
SGA+F +G++KF + N+ + N + V++ CG++H+A +T ++ FG
Sbjct: 208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFG 267
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVST-EGGNVYATGGNNEGQL 119
+ +GQLG S S P V L V ACGR HT G +Y+ G GQL
Sbjct: 268 AGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQL 327
Query: 120 GLGDTEERNT 129
G G T R +
Sbjct: 328 GTGSTSNRKS 337
Score = 44.7 bits (104), Expect = 4e-04
Identities = 30/82 (36%), Positives = 38/82 (46%), Gaps = 11/82 (13%)
Query: 12 GAVFTFGKSKFA---------ENNPGK-FWFKNDVPVHLSCGDEH-SAVVTGNNKLYMFG 60
G VFTFG + E NP K F + ++CG +H SA V + ++Y FG
Sbjct: 261 GGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320
Query: 61 SNNWGQLGLGSKSAISKPTCVK 82
GQLG GS S P VK
Sbjct: 321 LGGNGQLGTGSTSNRKSPFTVK 342
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 149 bits (375), Expect = 1e-35
Identities = 105/335 (31%), Positives = 173/335 (51%), Gaps = 16/335 (4%)
Query: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVK--LAACGRN-H 98
CG + V+ N + G ++G+LG G+ + T + AL+ V + +CG + H
Sbjct: 4034 CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 4093
Query: 99 TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
++ TE G V++ G + G+LG G+++ + I E ++ Q+S G SA +T D
Sbjct: 4094 SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGE-EVVQMSCGFKHSAVVTSD 4152
Query: 159 GRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGEL-YVFG 215
G+LF +G+ G++GL N SN +P++VT G + ++CG H+ V+ DG + + FG
Sbjct: 4153 GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
Query: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQ 273
+ + GKLGL N + +PQ + + I+ VACG + +V LT++ VYTFG +
Sbjct: 4213 DGDYGKLGLGNSTAKS--SPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 4270
Query: 274 LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333
L G + P+ I + I ++ G HT + G +Y +G G+LGLG
Sbjct: 4271 LPEGRAR-NHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLG--- 4326
Query: 334 FTNHF-IPTLCSNFLRFIVKLVACGGCHMVVFAAP 367
TNH PTL + V+ ++ G CH + AP
Sbjct: 4327 HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAP 4361
Score = 146 bits (369), Expect = 7e-35
Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 17/323 (5%)
Query: 52 GNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYAT 111
G +Y++G+ GQL ++ + + ++V CG+N T V G V A
Sbjct: 3995 GKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQV---ICGQNCTFVIQANGTVLAC 4051
Query: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQL--SAGSN-TSAALTEDGRLFMWGDNS 168
G + G+LG G++++ + VIS + QL S GS+ S ALTE G +F WGD
Sbjct: 4052 GEGSYGRLGQGNSDDLHVLTVISALQG-FVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 4110
Query: 169 EGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226
G++G N P+Q+ G+ V +SCG+ HSA VT+DG+L+ FG + G+LGL N
Sbjct: 4111 YGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 4170
Query: 227 QLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENA--VYTFGLGQFGQLGLGTFLFET 283
N + P+ V+ + ++ QVACG HT+ ++ + V+ FG G +G+LGLG ++
Sbjct: 4171 --TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 4228
Query: 284 SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLC 343
S P+ I+ + I ++CG + +T G +YTFG R +GL NH P
Sbjct: 4229 S-PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR--LIGLPEGRARNHNRPQQI 4285
Query: 344 SNFLRFIVKLVACGGCHMVVFAA 366
I++ VA G H + A+
Sbjct: 4286 PVLAGVIIEDVAVGAEHTLALAS 4308
Score = 143 bits (360), Expect = 7e-34
Identities = 88/277 (31%), Positives = 150/277 (54%), Gaps = 10/277 (3%)
Query: 41 SCG-DEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
SCG D HS +T + +++ +G ++G+LG G+ +P ++AL+ E+V +CG H+
Sbjct: 4087 SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 4146
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159
V T G ++ G + G+LGLG+T + ++ ++I Q++ G N + A++ DG
Sbjct: 4147 AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-YQIGQVACGLNHTLAVSADG 4205
Query: 160 RL-FMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216
+ + +GD G++GL N + PQ++ + G + ++CG S +T DG +Y FG
Sbjct: 4206 SMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG- 4264
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQL 274
++ +GLP NH PQ + + +I+ VA G EHT+ L N VY +G GQL
Sbjct: 4265 -QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQL 4323
Query: 275 GLGTFLFETSEPKVIENIRDQTISYISCGENHTALIT 311
GLG EP ++ ++ + + IS G H+A T
Sbjct: 4324 GLG-HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4359
Score = 122 bits (306), Expect = 1e-27
Identities = 85/267 (31%), Positives = 143/267 (53%), Gaps = 19/267 (7%)
Query: 8 MPDSGAVFTFGKSKFAENNPGKF----------WFKNDVPVHLSCGDEHSAVVTGNNKLY 57
+ +SG VF++G + + G + + V +SCG +HSAVVT + KL+
Sbjct: 4097 LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 4156
Query: 58 MFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTL-VSTEGGNVYATGGNNE 116
FG+ ++G+LGLG+ S P V AL+ ++ ACG NHTL VS +G V+A G +
Sbjct: 4157 TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDY 4216
Query: 117 GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176
G+LGLG++ +++ I IK+++ G+ S ALT+DG ++ +G + +
Sbjct: 4217 GKLGLGNSTAKSSPQKIDVLCG-IGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGR 4275
Query: 177 VSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNH-R 233
N PQQ+ + G + ++ G H+ + ++G++Y +G G+LGL + NH R
Sbjct: 4276 ARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHT---NHVR 4332
Query: 234 TPQLVSEIPEK-VIQVACGGEHTVVLT 259
P LV+ + K V Q++ G H+ T
Sbjct: 4333 EPTLVTGLQGKNVRQISAGRCHSAAWT 4359
Score = 111 bits (278), Expect = 2e-24
Identities = 89/334 (26%), Positives = 157/334 (47%), Gaps = 13/334 (3%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG---SKSAISKPTCVKALKPEKVKLAACGR 96
+ G + V++ + + G ++G+LGLG ++S + K T +KV +
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSD 467
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
HTL T G V++ G + G+LG G++ + +I + +SAG SAA+T
Sbjct: 468 GHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
Query: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGE-LYVFG 215
EDG L+ WG+ G++G + ++ +P V V +SCG H+ ++ DG ++ FG
Sbjct: 528 EDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFG 587
Query: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVAC-GGEHTVVLTENA-VYTFGLGQFGQ 273
+NGKLG + P+++ + I+ C G + ++ LT VY +G G
Sbjct: 588 GGDNGKLGHGD--TNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG--AC 643
Query: 274 LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333
LG G+ PK+IE + I +S G++H ++ +Y +G+ G+ G G N
Sbjct: 644 LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQG--N 701
Query: 334 FTNHFI-PTLCSNFLRFIVKLVACGGCHMVVFAA 366
T P S ++ ++ G H + + A
Sbjct: 702 STGPITKPKKVSGLDGIAIQQISAGTSHSLAWTA 735
Score = 90.9 bits (224), Expect = 4e-18
Identities = 70/228 (30%), Positives = 117/228 (51%), Gaps = 9/228 (3%)
Query: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
V V +S G HSA VT + +LY +G ++G+LG G ++ + PT VK + V +CG
Sbjct: 512 VVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCG 569
Query: 96 RNHTL-VSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
+HT+ +S +G V++ GG + G+LG GDT VI I+++ AGS +S A
Sbjct: 570 SSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMF-IRKVCAGSQSSLA 628
Query: 155 LTEDGRLFMWGDNSEGQIGLKNVSNV--CVPQQVTIGKPVSWISCGYYHSAFVTTDGELY 212
LT G+++ WG + G + + + +++ + V +S G H ++ D E+Y
Sbjct: 629 LTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVD-VSIGDSHCLALSHDNEVY 687
Query: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT 259
+G G+ G N G P+ VS + I Q++ G H++ T
Sbjct: 688 AWGNNSMGQCGQGNS-TGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
Score = 87.4 bits (215), Expect = 5e-17
Identities = 63/223 (28%), Positives = 109/223 (48%), Gaps = 13/223 (5%)
Query: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVF 214
++E +++WG NS Q+ + P+ I G Y + ++TDG +
Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRAC 427
Query: 215 GEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGE----HTVVLT-ENAVYTFGLG 269
G+ G+LGL + N T + ++ P + I+ + HT+ T E V+++G G
Sbjct: 428 GKGSYGRLGLGDS--NNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
Query: 270 QFGQLGLGTFLFETSEPKVIEN-IRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
+G+LG G + PK+I+ ++ + + +S G H+A +T+ G +YT+G+G G+LG
Sbjct: 486 DYGKLGHGNSSTQ-KYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
Query: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGV 371
G N N IPTL + V V+CG H + + R V
Sbjct: 545 HGDSNSRN--IPTLVKDISN--VGEVSCGSSHTIALSKDGRTV 583
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 140 bits (354), Expect = 4e-33
Identities = 115/344 (33%), Positives = 166/344 (48%), Gaps = 29/344 (8%)
Query: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
VP SC H + T + G + GQLGLG K + ++ PE V A G
Sbjct: 34 VPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAG 92
Query: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
HT+ ++ G VY+ G N+EG LG DT + V + K+ Q+SAG + +AAL
Sbjct: 93 GMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAAL 151
Query: 156 TEDGRLFMWGD--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELY 212
T+DGR+F+WG ++ G IGL + + VP QV + PV ++ G H +T DG+LY
Sbjct: 152 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLY 211
Query: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVV 257
G E G+LG +L N Q + +P+ V+ CG T
Sbjct: 212 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 271
Query: 258 LT-ENAVYTFGLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDI 313
++ E VY FGL + QLG GT P+ + + ++ T S++ S G++HT +
Sbjct: 272 ISHEGHVYGFGLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE 329
Query: 314 GLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
G Y+ G +G+LGLG E IPTL S V VACG
Sbjct: 330 GKAYSLGRAEYGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 370
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 68 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 126
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 127 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQ-- 184
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+G + + + VP+
Sbjct: 185 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 244
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 245 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT--ESCFIPQN 302
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 303 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 361
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 362 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 421 VSSGGQHTVL 430
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 151 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 208
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 209 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 267
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 268 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 325
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 326 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 385
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 386 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 434
Score = 61.2 bits (147), Expect = 4e-09
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC--GRNHT 99
CG + ++ +Y FG +N+ QLG + P + + K G++HT
Sbjct: 264 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 323
Query: 100 LVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
+ G Y+ G G+LGLG+ EE++ +IS + + ++ G++ A+T+D
Sbjct: 324 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA---VSSVACGASVGYAVTKD 380
Query: 159 GRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP-----VSWISCGYYHSAFVTTDGE 210
GR+F WG + Q+G + P ++ +GK V +S G H+ + D E
Sbjct: 381 GRVFAWGMGTNYQLGTGQDEDAWSPVEM-MGKQLENRVVLSVSSGGQHTVLLVKDKE 436
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 139 bits (349), Expect = 1e-32
Identities = 96/287 (33%), Positives = 151/287 (52%), Gaps = 9/287 (3%)
Query: 43 GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102
G+ HS ++ N+++ G N+ GQLG P ++AL+ V L +CG+ H+L
Sbjct: 31 GERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90
Query: 103 TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLF 162
G V+A G +EGQLG+G+ +E + ++ KI Q+S G S AL++D ++F
Sbjct: 91 CHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVF 150
Query: 163 MWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPEN 219
WG NS GQ+GL K + PQ+V G P++ ++ G HS ++ G + +G
Sbjct: 151 SWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210
Query: 220 GKLGLPNQLLG-NHRTPQLVSEIPE-KVIQVACGGEHTVVLTENA-VYTFGLGQFGQLGL 276
G+L L + + P V + V+ ++CG HT VLT++ V+TFG + GQLG
Sbjct: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270
Query: 277 GTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDG 322
E P+++E I D +S I CG HT A + G + +FG G
Sbjct: 271 SP-TPEKRGPQLVERI-DGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
Score = 119 bits (297), Expect = 1e-26
Identities = 83/238 (34%), Positives = 119/238 (50%), Gaps = 10/238 (4%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAIS-KPTCVKALKPEKVKLAACGRNH 98
+SCG EHS V +++ +G+ + GQLG+G IS P + L K+ +CG H
Sbjct: 80 VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
Query: 99 TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
+L ++ V++ G N+ GQLGLG + Q++AG S AL+
Sbjct: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
Query: 159 GRLFMWGDNSEGQIGL--KNV---SNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
G F WG NS GQ+ L +NV SN + V +ISCG H+A +T DG+++
Sbjct: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFT 259
Query: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV--VLTENAVYTFGLG 269
FG+ +G+LG R PQLV I V Q+ CG HT+ V T V +FG G
Sbjct: 260 FGDNRSGQLGY--SPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
Score = 115 bits (289), Expect = 1e-25
Identities = 75/244 (30%), Positives = 126/244 (51%), Gaps = 9/244 (3%)
Query: 92 AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNT 151
AA G H+L+ V + G N+ GQLG + I + + +S G
Sbjct: 28 AASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLI-VDLVSCGKEH 86
Query: 152 SAALTEDGRLFMWGDNSEGQIGLKNVSNVC-VPQQVTIGKPVSWI--SCGYYHSAFVTTD 208
S A+ GR+F WG SEGQ+G+ + P+++ + I SCG+YHS ++ D
Sbjct: 87 SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146
Query: 209 GELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLTE-NAVYTF 266
+++ +G+ +G+LGL + + +PQ V + + QVA GG H+ L+ + +
Sbjct: 147 SQVFSWGKNSHGQLGLGKEF-PSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGW 205
Query: 267 GLGQFGQLGLG--TFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324
G GQL L ++++P + +++ + YISCG+ HTA++T G ++TFGD R
Sbjct: 206 GSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRS 265
Query: 325 GKLG 328
G+LG
Sbjct: 266 GQLG 269
Score = 91.3 bits (225), Expect = 3e-18
Identities = 74/233 (31%), Positives = 112/233 (48%), Gaps = 14/233 (6%)
Query: 18 GKSKFAENNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSK-SAI 75
G+ K P K ND+ + +SCG HS ++ +++++ +G N+ GQLGLG + +
Sbjct: 110 GEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQ 169
Query: 76 SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISF 135
+ P V++L+ + A G H+ + G + G N+ GQL L RN +
Sbjct: 170 ASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSG---RNVPVQSNK 226
Query: 136 FTSEHKIKQL-----SAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-TIG 189
S +K L S G +A LT+DG++F +GDN GQ+G PQ V I
Sbjct: 227 PLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERID 286
Query: 190 KPVSWISCGYYHS-AFVTTDGELYVFGE--PENGKLGLPNQLLGNHRTPQLVS 239
VS I CG YH+ A+V T G++ FG + K P L N L+S
Sbjct: 287 GLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLIS 339
Score = 87.4 bits (215), Expect = 5e-17
Identities = 59/228 (25%), Positives = 112/228 (49%), Gaps = 6/228 (2%)
Query: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCG 198
++ Q ++G S L + R+ GDNS GQ+G + +P+ + + V +SCG
Sbjct: 24 ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCG 83
Query: 199 YYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVV 257
HS V G ++ +G G+LG+ + TP+ + + + K+IQV+CG H++
Sbjct: 84 KEHSLAVCHKGRVFAWGAGSEGQLGI-GEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
Query: 258 LTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316
L++++ V+++G GQLGLG + P+ + ++ ++ ++ G H+ ++ G
Sbjct: 143 LSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS 202
Query: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI-VKLVACGGCHMVV 363
+ +G G+L L N L L+ + V ++CG H V
Sbjct: 203 FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 139 bits (349), Expect = 1e-32
Identities = 99/280 (35%), Positives = 145/280 (51%), Gaps = 10/280 (3%)
Query: 51 TGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-HTLVSTEGGNVY 109
T N+++++ G+N G LGLG + +P + +L +K+ + G H +++T G V+
Sbjct: 62 TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121
Query: 110 ATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSE 169
G N QLG G T IS S ++ +++ GS S LT DG +F WG N+
Sbjct: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181
Query: 170 GQIGLKNVSNVCVPQQVT---IGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226
GQ+G + N +P++VT K V I+CG V GE+YV+G NG+LGL N
Sbjct: 182 GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN 241
Query: 227 QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETS 284
GN TP V+ + +V +VACG HT+VLT E VY +G +GQLG G S
Sbjct: 242 S--GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN-KSNQS 298
Query: 285 EPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGR 323
P + +D+ I +C HT A T G +Y +G R
Sbjct: 299 YPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCR 338
Score = 111 bits (278), Expect = 2e-24
Identities = 95/332 (28%), Positives = 153/332 (46%), Gaps = 29/332 (8%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAIS--KPTCVKALKPEKVKLAACGRN 97
L GD V + L M W L S+ + + CV + G N
Sbjct: 7 LFSGDSGKPVQATLSSLKMLDVGKWPIFSLCSEEELQLIRQACV---------FGSAG-N 56
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL-T 156
L +T ++ G N G LGLGD + + + KI LS GS L T
Sbjct: 57 EVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGK-KIACLSYGSGPHIVLAT 115
Query: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG---KPVSWISCGYYHSAFVTTDGELYV 213
+G +F WG N+ Q+G ++ VP ++ K V ++CG YHS +T+DGE++
Sbjct: 116 TEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFA 175
Query: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEK--VIQVACGGEHTVVLTENA-VYTFGLGQ 270
+G +G++G + + N P+ V+ + V+ +ACG + + + VY +G
Sbjct: 176 WGYNNSGQVGSGSTV--NQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNG 233
Query: 271 FGQLGLGTFLFETSEPKV--IENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
GQLGLG + + +V ++ IR Q ++ CG HT ++TD G +Y +G +G+LG
Sbjct: 234 NGQLGLGNSGNQPTPCRVAALQGIRVQRVA---CGYAHTLVLTDEGQVYAWGANSYGQLG 290
Query: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
G N +N PT + I+++ AC H
Sbjct: 291 TG--NKSNQSYPTPVTVEKDRIIEIAACHSTH 320
Score = 99.8 bits (247), Expect = 9e-21
Identities = 72/236 (30%), Positives = 116/236 (49%), Gaps = 18/236 (7%)
Query: 7 LMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLS------------CGDEHSAVVTGNN 54
L G VFT+G + +++ G VP H+S CG HS V+T +
Sbjct: 113 LATTEGEVFTWGHNAYSQLGNGTT-NHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 171
Query: 55 KLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLA-ACGRNHTLVSTEGGNVYATGG 113
+++ +G NN GQ+G GS P V KV + ACG+ + + G VY G
Sbjct: 172 EVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGY 231
Query: 114 NNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIG 173
N GQLGLG++ + T ++ ++++++ G + LT++G+++ WG NS GQ+G
Sbjct: 232 NGNGQLGLGNSGNQPTPCRVAALQG-IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Query: 174 LKNVSNVCVPQQVTIGKP--VSWISCGYYH-SAFVTTDGELYVFGEPENGKLGLPN 226
N SN P VT+ K + +C H SA T G +Y++G+ + LP+
Sbjct: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPH 346
Score = 86.3 bits (212), Expect = 1e-16
Identities = 66/224 (29%), Positives = 113/224 (50%), Gaps = 11/224 (4%)
Query: 146 SAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYY-HS 202
SAG+ D +F+ G N G +GL +V + P+++ GK ++ +S G H
Sbjct: 53 SAGNEVLYTTVND-EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHI 111
Query: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE--IPEKVIQVACGGEHTVVLTE 260
TT+GE++ +G +LG N + P +S ++VI+VACG H++VLT
Sbjct: 112 VLATTEGEVFTWGHNAYSQLG--NGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
Query: 261 NA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTF 319
+ V+ +G GQ+G G+ + + +V ++++ + I+CG+ + D G +Y +
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVW 229
Query: 320 GDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
G +G+LGLG N N P + V+ VACG H +V
Sbjct: 230 GYNGNGQLGLG--NSGNQPTPCRVAALQGIRVQRVACGYAHTLV 271
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 136 bits (342), Expect = 9e-32
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 116
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 117 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 175
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 176 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 235
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 236 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 295
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 296 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 353
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 354 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 384
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 82 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 140
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 141 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 198
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 199 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 258
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 259 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 316
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 317 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 375
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 376 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 434
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 435 VSSGGQHTVL 444
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 165 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 222
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 223 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 281
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 282 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 339
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 340 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 399
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 400 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 448
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 136 bits (342), Expect = 9e-32
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 51 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 109
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 110 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 167
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 168 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 285
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 286 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 344
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 345 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 404 VSSGGQHTVL 413
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 136 bits (342), Expect = 9e-32
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 51 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 109
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 110 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 167
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 168 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 285
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 286 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 344
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 345 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 404 VSSGGQHTVL 413
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 136 bits (342), Expect = 9e-32
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 51 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 109
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 110 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 167
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 168 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 285
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 286 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 344
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 345 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 404 VSSGGQHTVL 413
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 136 bits (342), Expect = 9e-32
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 51 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 109
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 110 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 167
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 168 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 285
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 286 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 344
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 345 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 404 VSSGGQHTVL 413
Score = 75.9 bits (185), Expect = 1e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 131 bits (330), Expect = 2e-30
Identities = 96/281 (34%), Positives = 143/281 (50%), Gaps = 10/281 (3%)
Query: 50 VTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-HTLVSTEGGNV 108
VT N+++++FG N LG G + P ++ L +K+K + G H L+STE G V
Sbjct: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
Query: 109 YATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNS 168
YA G N QLG G T + + ++ +++ GS+ S AL DG +F WG N+
Sbjct: 97 YAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNN 156
Query: 169 EGQIGLKNVSNVCVPQQVTIG---KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
GQ+G + +N P++VT K V I+CG S V +GE+Y +G NG+LGL
Sbjct: 157 CGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLG 216
Query: 226 NQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFET 283
N GN TP V+ + + Q+ CG HT+ LT E +Y +G +GQLG G
Sbjct: 217 NN--GNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGN-KNNL 273
Query: 284 SEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGR 323
P I +++ + +C HT A T G +Y +G R
Sbjct: 274 LSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
Score = 110 bits (274), Expect = 7e-24
Identities = 82/271 (30%), Positives = 128/271 (47%), Gaps = 13/271 (4%)
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL- 155
+ L T+ V+ G N LG GD + + + KIK LS GS L
Sbjct: 32 SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGK-KIKSLSYGSGPHVLLS 90
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG---KPVSWISCGYYHSAFVTTDGELY 212
TEDG ++ WG N Q+G + P QV K V ++CG +HS + DGE++
Sbjct: 91 TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVF 150
Query: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSEIP--EKVIQVACGGEHTVVLTENA-VYTFGLG 269
+G G++G + N TP+ V+ ++V+ +ACG ++ + +N VY +G
Sbjct: 151 AWGYNNCGQVGSGST--ANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
Query: 270 QFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGL 329
GQLGLG + + P + + ++ I CG HT +TD GL+Y +G +G+LG
Sbjct: 209 GNGQLGLGNNGNQLT-PVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267
Query: 330 GLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
G +N N P +V++ AC H
Sbjct: 268 GNKN--NLLSPAHIMVEKERVVEIAACHSAH 296
Score = 106 bits (264), Expect = 1e-22
Identities = 69/230 (30%), Positives = 114/230 (49%), Gaps = 8/230 (3%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPT--CVKALKPEKVKLAACGRNHTLVST 103
H + T + +Y +G N + QLG G+ + P C L + V++A CG +H++
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVA-CGSHHSMALA 144
Query: 104 EGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFM 163
G V+A G NN GQ+G G T + T ++ ++ ++ G +S A+ ++G ++
Sbjct: 145 ADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204
Query: 164 WGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGK 221
WG N GQ+GL N N P +V V+ I CGY H+ +T +G LY +G G+
Sbjct: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQ 264
Query: 222 LGLPNQLLGNHRTPQLVSEIPEKVIQV-ACGGEHTVVLTENAVYTFGLGQ 270
LG N+ N +P + E+V+++ AC HT + + GQ
Sbjct: 265 LGTGNK--NNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312
Score = 95.9 bits (237), Expect = 1e-19
Identities = 61/193 (31%), Positives = 100/193 (51%), Gaps = 5/193 (2%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV-KALKPEKVKLAACGR 96
V ++CG HS + + +++ +G NN GQ+G GS + P V L ++V ACG+
Sbjct: 131 VEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQ 190
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
++ + G VY G N GQLGLG+ + T ++ S + Q+ G + ALT
Sbjct: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV-CVNQIVCGYAHTLALT 249
Query: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCGYYH-SAFVTTDGELYV 213
++G L+ WG N+ GQ+G N +N+ P + + K V +C H SA T G +Y+
Sbjct: 250 DEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYM 309
Query: 214 FGEPENGKLGLPN 226
+G+ + LP+
Sbjct: 310 WGQCRGQSVILPH 322
Score = 85.1 bits (209), Expect = 2e-16
Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 8/191 (4%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
V ++CG S V N ++Y +G N GQLGLG+ P V AL V CG
Sbjct: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYA 243
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSA--GSNTSAAL 155
HTL T+ G +YA G N GQLG G+ + N + ++ +++A ++TSAA
Sbjct: 244 HTLALTDEGLLYAWGANTYGQLGTGN--KNNLLSPAHIMVEKERVVEIAACHSAHTSAAK 301
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKP-VSWISCGYYHSAFVTTDGEL- 211
T+ G ++MWG + L ++++ V P VSW H F+T L
Sbjct: 302 TQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESLK 361
Query: 212 YVFGEPENGKL 222
F PE L
Sbjct: 362 KEFDSPETADL 372
Score = 79.0 bits (193), Expect = 2e-14
Identities = 58/219 (26%), Positives = 104/219 (47%), Gaps = 8/219 (3%)
Query: 148 GSNTSAAL--TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYY-HS 202
G++ S AL T++ +F++G N +G + + VP+++ GK + +S G H
Sbjct: 28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHV 87
Query: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-EN 261
T DG +Y +G +LG G + + ++V++VACG H++ L +
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADG 147
Query: 262 AVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGD 321
V+ +G GQ+G G+ + + KV + + + I+CG+ + + D G +Y +G
Sbjct: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
Query: 322 GRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
+G+LGLG N N P + V + CG H
Sbjct: 208 NGNGQLGLG--NNGNQLTPVRVAALHSVCVNQIVCGYAH 244
Score = 51.6 bits (122), Expect = 3e-06
Identities = 41/135 (30%), Positives = 61/135 (45%), Gaps = 5/135 (3%)
Query: 234 TPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
+PQ ++ I + + E V + V+ FGL LG G T PK +E +
Sbjct: 14 SPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ-STLVPKKLEGLC 72
Query: 294 DQTISYISCGEN-HTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPT-LCSNFLRFIV 351
+ I +S G H L T+ G++Y +G + +LG G N P +C+N L V
Sbjct: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN--QGIAPVQVCTNLLIKQV 130
Query: 352 KLVACGGCHMVVFAA 366
VACG H + AA
Sbjct: 131 VEVACGSHHSMALAA 145
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 129 bits (324), Expect = 1e-29
Identities = 98/336 (29%), Positives = 165/336 (49%), Gaps = 15/336 (4%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-SKSAISKPTCVKALKPEKVKLAAC-- 94
V ++ G + VT K+Y G G+LGLG S + P + AL VK A
Sbjct: 2995 VQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHS 3054
Query: 95 GRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
G H T G V++ G ++G+LG + +I ++ +I+ ++ GS+ SAA
Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAA 3113
Query: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYY--HSAFVTTDGE 210
LT G L+ WG G++G + + P+ V + G V ++CG + +T +G
Sbjct: 3114 LTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGL 3173
Query: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAV-YTFGL 268
++ +G+ + GKLG N PQ + + + V Q+ CG + ++ LT++ V +T+G
Sbjct: 3174 VFSWGDGDFGKLGRGGSEGCN--IPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
Query: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
G + +LG G+ + +P+V+E +R + I +++ G H +TD G +Y +GD HG+ G
Sbjct: 3232 GDYFRLGHGSDV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 3290
Query: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVF 364
G PTL + VACG H V +
Sbjct: 3291 NGTTTVNRK--PTLVQGLEGQKITRVACGSSHSVAW 3324
Score = 129 bits (324), Expect = 1e-29
Identities = 80/282 (28%), Positives = 147/282 (52%), Gaps = 10/282 (3%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
V + G H+ +T + K++ +G + G+LG S+ KP ++ALK ++++ ACG +
Sbjct: 3050 VAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSS 3109
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN--TSAAL 155
H+ T G +Y G G+LG GD + ++ H++ Q++ GS + AL
Sbjct: 3110 HSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLG-HRVIQVACGSRDAQTLAL 3168
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKPVSWISCGYYHSAFVTTDGELYV 213
T++G +F WGD G++G +PQ + G+ V I CG S +T G ++
Sbjct: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT 3228
Query: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLTENA-VYTFGLGQF 271
+G+ + +LG + + + R PQ+V + +K++ VA G H + +T++ VY +G
Sbjct: 3229 WGKGDYFRLGHGSDV--HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDH 3286
Query: 272 GQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDI 313
GQ G GT +P +++ + Q I+ ++CG +H+ T +
Sbjct: 3287 GQQGNGTTTV-NRKPTLVQGLEGQKITRVACGSSHSVAWTTV 3327
Score = 129 bits (323), Expect = 1e-29
Identities = 97/337 (28%), Positives = 164/337 (48%), Gaps = 14/337 (4%)
Query: 37 PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAA--C 94
PV L G++ VT + KLY G G+LG+G ++S PT +++++ +K A
Sbjct: 3987 PVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNS 4046
Query: 95 GRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
G H L + G VY+ G +G+LG G+ + VI ++ ++AG SA
Sbjct: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRG-IEVVDVAAGGAHSAC 4105
Query: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGY--YHSAFVTTDGE 210
+T G L+ WG G++G + + P+ V G V I+CG + +T D
Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165
Query: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLTEN-AVYTFGL 268
++ +G+ + GKLG + P + + V++V CG + +V LT++ AVYT+G
Sbjct: 4166 VWSWGDGDYGKLGRGGS--DGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGK 4223
Query: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
G + +LG G+ P+ ++ ++ + + I+ G H T+ G +YT+GD G+LG
Sbjct: 4224 GDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
Query: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
G N P L + V VACG H + ++
Sbjct: 4283 DGTTNAIQR--PRLVAALQGKKVNRVACGSAHTLAWS 4317
Score = 125 bits (313), Expect = 2e-28
Identities = 93/291 (31%), Positives = 147/291 (50%), Gaps = 11/291 (3%)
Query: 48 AVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGN 107
+ T K++++G N+ QLG S I P+ + L V A G T G
Sbjct: 2953 SAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
Query: 108 VYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLS--AGSNTSAALTEDGRLFMWG 165
VYA G G+LGLG + S + +K+++ +G + ALT DG++F WG
Sbjct: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
Query: 166 DNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223
+ +G++G + N P+ + K + I+CG HSA +T+ GELY +G E G+LG
Sbjct: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
Query: 224 LPNQLLGNHRTPQLVSE-IPEKVIQVACGGE--HTVVLT-ENAVYTFGLGQFGQLGLGTF 279
+ P++V + +VIQVACG T+ LT E V+++G G FG+LG G
Sbjct: 3133 HGDNT--TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG- 3189
Query: 280 LFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG 330
+ P+ IE + Q + I CG + +T G+++T+G G + +LG G
Sbjct: 3190 SEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3240
Score = 111 bits (277), Expect = 3e-24
Identities = 75/231 (32%), Positives = 118/231 (51%), Gaps = 8/231 (3%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-- 97
++CG HSA +T + +LY +G +G+LG G + KP VK L +V ACG
Sbjct: 3104 IACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDA 3163
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
TL T+ G V++ G + G+LG G +E N I + + Q+ G+ S ALT+
Sbjct: 3164 QTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-VCQIECGAQFSLALTK 3222
Query: 158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFG 215
G ++ WG ++G + +V PQ V GK + ++ G H VT G++Y +G
Sbjct: 3223 SGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWG 3282
Query: 216 EPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAVYT 265
+ ++G+ G N +R P LV + +K+ +VACG H+V T V T
Sbjct: 3283 DNDHGQQG--NGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVAT 3331
Score = 102 bits (253), Expect = 2e-21
Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 30/310 (9%)
Query: 64 WGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEG---QLG 120
WG +G + + P + L V AC L+ + G VY N++ QL
Sbjct: 428 WGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV 487
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
G RN + + H + AL G ++ WG G++G + +
Sbjct: 488 QG-LASRNIVKIAAHSDGHHYL-----------ALAATGEVYSWGCGDGGRLGHGDTVPL 535
Query: 181 CVPQQVTI------GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT 234
P+ ++ GK V I+CG +SA +T +GELY +G G+LG + +
Sbjct: 536 EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS--EDEAI 593
Query: 235 PQLVSEIPE-KVIQVACGG--EHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIE 290
P LV+ + KVI VACG T+ +TEN V+++G G +G+LG G PK+IE
Sbjct: 594 PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIE 652
Query: 291 NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI 350
++D + + CG + +T G +Y++G G + +LG G E + P L
Sbjct: 653 KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRY--PKLLEGLQGKK 710
Query: 351 VKLVACGGCH 360
V VA G H
Sbjct: 711 VIDVAAGSTH 720
Score = 98.6 bits (244), Expect = 2e-20
Identities = 70/236 (29%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
VH++CG +SA +T +LY +G N+G+LG GS + P V LK KV ACG
Sbjct: 554 VHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG 613
Query: 98 --HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
TL TE G V++ G + G+LG G ++ T +I +K + GS S AL
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVK-VRCGSQFSIAL 672
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYV 213
T+DG+++ WG ++G +V P+ + GK V ++ G H +T D E++
Sbjct: 673 TKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHS 732
Query: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEK-VIQVACGGEHTVVLTENAVYTFGL 268
+G N + + L P + + K ++ +ACG + + + ++ GL
Sbjct: 733 WG--SNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSEWSIGL 786
Score = 92.8 bits (229), Expect = 1e-18
Identities = 70/236 (29%), Positives = 119/236 (50%), Gaps = 12/236 (5%)
Query: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGY 199
I++ +AG ++A + ++F+WG N + Q+G S + VP + V ++ G
Sbjct: 2944 IRKKAAGLESAATIRT--KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGS 3001
Query: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTV 256
VT +G++Y GE NG+LGL G P+ ++ + V++ V GG H
Sbjct: 3002 KSLFAVTVEGKVYACGEATNGRLGLGISS-GTVPIPRQITALSSYVVKKVAVHSGGRHAT 3060
Query: 257 VLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGL 315
LT + V+++G G G+LG + + +P++IE ++ + I I+CG +H+A +T G
Sbjct: 3061 ALTVDGKVFSWGEGDDGKLGHFSRM-NCDKPRLIEALKTKRIRDIACGSSHSAALTSSGE 3119
Query: 316 MYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGV 371
+YT+G G +G+LG G + T P + L V VACG A G+
Sbjct: 3120 LYTWGLGEYGRLGHG--DNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGL 3173
Score = 70.9 bits (172), Expect = 5e-12
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
+ V GD + VT N +++ +G ++G+LG G P ++ L+ V CG
Sbjct: 606 IDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCG 665
Query: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
++ T+ G VY+ G + +LG G TEE + + K+ ++AGS AL
Sbjct: 666 SQFSIALTKDGQVYSWGKGDNQRLGHG-TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLAL 724
Query: 156 TEDGRLFMWGDNSEGQ 171
TED + WG N + Q
Sbjct: 725 TEDSEVHSWGSNDQCQ 740
Score = 67.0 bits (162), Expect = 7e-11
Identities = 47/159 (29%), Positives = 75/159 (47%), Gaps = 11/159 (6%)
Query: 8 MPDSGAVFTFGKSKFAE---------NNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLY 57
+ D G VF++G F + N P N V + CG + S +T + ++
Sbjct: 3168 LTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVW 3227
Query: 58 MFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
+G ++ +LG GS + KP V+ L+ +K+ A G H L T+ G VYA G N+ G
Sbjct: 3228 TWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHG 3287
Query: 118 QLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Q G G T ++ + KI +++ GS+ S A T
Sbjct: 3288 QQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWT 3325
Score = 55.8 bits (133), Expect = 2e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 11 SGAVFTFGKSKFAENNPGKF----------WFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
SGAV+T+GK + G + + ++ G H T + ++Y +G
Sbjct: 4215 SGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTL 100
N+ GQLG G+ +AI +P V AL+ +KV ACG HTL
Sbjct: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4314
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 120 bits (300), Expect = 7e-27
Identities = 87/271 (32%), Positives = 137/271 (50%), Gaps = 22/271 (8%)
Query: 66 QLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTE 125
QL GS A + P C+K K K+ G H L+ + G + + L
Sbjct: 77 QLLAGSGGART-PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFES-- 133
Query: 126 ERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQ 184
E KI Q++ G S AL++ G LF WG N GQ+G+ + + PQ
Sbjct: 134 ----------ILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQ 183
Query: 185 QV--TIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP 242
V G P++ IS G HS ++ G +Y +G+ E G+LGL + + P L+ +
Sbjct: 184 IVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGH--TESKDDPSLIEGLD 241
Query: 243 -EKVIQVACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
+KV VACGG H+ +LT++ ++TFG G+ GQLG + E P ++ + ++ I
Sbjct: 242 NQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNEL-RPCLVAELVGYRVTQI 300
Query: 301 SCGENHT-ALITDIGLMYTFGDGRHGKLGLG 330
+CG HT A ++D+G +++FG G+ G+LG G
Sbjct: 301 ACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331
Score = 114 bits (285), Expect = 4e-25
Identities = 73/235 (31%), Positives = 128/235 (54%), Gaps = 16/235 (6%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSK-SAISKPTCVKALKPEKVKLAACGR 96
+ ++CGD HS ++ +L+ +G N GQLG+G K + + P V+ L + + G
Sbjct: 141 IQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGE 200
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
H++ + GN+Y+ G N GQLGLG TE ++ +I ++ K++ ++ G + SA LT
Sbjct: 201 AHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQ-KVEFVACGGSHSALLT 259
Query: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHS-AFVTTDGELYV 213
+DG LF +G GQ+G + N P V +G V+ I+CG +H+ A+V+ G+++
Sbjct: 260 QDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFS 319
Query: 214 FGEPENGKLG----------LPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL 258
FG ++G+LG LP ++ + +L S EK + + GG +++L
Sbjct: 320 FGSGKDGQLGNGGTRDQLMPLPVKVSSSEEL-KLESHTSEKELIMIAGGNQSILL 373
Score = 113 bits (282), Expect = 8e-25
Identities = 70/229 (30%), Positives = 127/229 (55%), Gaps = 17/229 (7%)
Query: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYY 200
KI + G+ L+ DG+ F + + S +K++ + Q+ K + I+CG Y
Sbjct: 98 KIHSVDQGAEHMLILSSDGKPFEYDNYS-----MKHLRFESILQE----KKIIQITCGDY 148
Query: 201 HSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLT 259
HS ++ GEL+ +G+ +G+LG+ + TPQ+V + + Q++ G H++ L+
Sbjct: 149 HSLALSKGGELFAWGQNLHGQLGVGRKFPST-TTPQIVEHLAGVPLAQISAGEAHSMALS 207
Query: 260 ENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYT 318
+ +Y++G + GQLGLG +P +IE + +Q + +++CG +H+AL+T GL++T
Sbjct: 208 MSGNIYSWGKNECGQLGLG-HTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFT 266
Query: 319 FGDGRHGKLGLGLENFT-NHFIPTLCSNFLRFIVKLVACGGCHMVVFAA 366
FG G+HG+LG N T N P L + + + V +ACG H + + +
Sbjct: 267 FGAGKHGQLG---HNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
Score = 80.9 bits (198), Expect = 4e-15
Identities = 46/189 (24%), Positives = 93/189 (49%), Gaps = 13/189 (6%)
Query: 12 GAVFTFGKSKFAENNPGKFWFKNDVP-----------VHLSCGDEHSAVVTGNNKLYMFG 60
G +F +G++ + G+ + P +S G+ HS ++ + +Y +G
Sbjct: 157 GELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWG 216
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
N GQLGLG + P+ ++ L +KV+ ACG +H+ + T+ G ++ G GQLG
Sbjct: 217 KNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLG 276
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGS-NTSAALTEDGRLFMWGDNSEGQIGLKNVSN 179
T+ +++ +++ Q++ G +T A +++ G++F +G +GQ+G +
Sbjct: 277 HNSTQNELRPCLVAELVG-YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRD 335
Query: 180 VCVPQQVTI 188
+P V +
Sbjct: 336 QLMPLPVKV 344
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 119 bits (298), Expect = 1e-26
Identities = 89/294 (30%), Positives = 144/294 (48%), Gaps = 21/294 (7%)
Query: 56 LYMFGSNNWGQLGLGSKSAISKPTCVKAL-KPEKVKLAACGRNHTLVSTEGGNVYATGGN 114
L+ +G+N++GQLGLG K + P + KP V+ G H+ V T+GG+++ G N
Sbjct: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
Query: 115 NEGQLGLGDTEERNTFHVISFFTSEHK-----IKQLSAGSNTSAALTEDGRLFMWGDNSE 169
+GQLGLG TE+ I +FT I+Q++ G + + LTE+G++ G NS
Sbjct: 77 KDGQLGLGHTED------IPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSF 130
Query: 170 GQIGLKNVSNVCV-PQQVTIGKP-VSWISCGYYHSAFVTTDGELYVFGE--PENGKLGLP 225
GQ+G+ + CV PQ + + K V I+ G H+ T G ++ +G G+ P
Sbjct: 131 GQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCP 190
Query: 226 NQLLGNHRTPQLVSEIP----EKVIQVACGGEHTVVLTE-NAVYTFGLGQFGQLGLGTFL 280
Q L T + S + K + V G +H+ LT+ VY +G + GQL
Sbjct: 191 GQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAF 250
Query: 281 FETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENF 334
+ +++ ++ I G H T+ G M+T+G +G+LG LE +
Sbjct: 251 LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETY 304
Score = 108 bits (271), Expect = 2e-23
Identities = 112/403 (27%), Positives = 163/403 (40%), Gaps = 54/403 (13%)
Query: 2 REPE--ELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPV--------------HLSCGDE 45
REP E P + A+F +G + + + G K DV + ++ G
Sbjct: 3 REPSASEAAPAAAALFAWGANSYGQLGLGH---KEDVLLPQQLNDFCKPRSVRRITGGGG 59
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
HSAVVT L++ G N GQLGLG I T K+L ++ ACG + T++ TE
Sbjct: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G V + G N+ GQLG+ R + + K+ ++AG + A T G +F WG
Sbjct: 120 GQVLSCGSNSFGQLGVPHGPRRCVVPQ-AIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178
Query: 166 DNSEGQIGLKNVSNVCVPQQVTIGKP----------VSWISCGYYHSAFVTTDGELYVFG 215
G + +P T +P + G HSA +T GE+YV+G
Sbjct: 179 -TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWG 237
Query: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQL 274
++G+L L + + EKV + G H V TE ++T+G +GQL
Sbjct: 238 SNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQL 297
Query: 275 GLGTFLFE-----------------TSEPKVIENIRDQTISYISCGENHTALITDIGLMY 317
G +E S P + T +SCG H I G+ Y
Sbjct: 298 GRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGAT--EVSCGSEHNLAIIG-GVCY 354
Query: 318 TFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
++G HG G G E N + P L LV CG H
Sbjct: 355 SWGWNEHGMCGDGTE--ANVWAPKPVQALLSSSGLLVGCGAGH 395
Score = 89.4 bits (220), Expect = 1e-17
Identities = 78/309 (25%), Positives = 138/309 (44%), Gaps = 47/309 (15%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGL--GSKSAISKPTCVKALKPEKVKLAACGRN 97
++CG + + ++T N ++ GSN++GQLG+ G + + P ++ L EKV A G
Sbjct: 106 VACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVV-PQAIE-LHKEKVVCIAAGLR 163
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEER----NTFHVISFFTSEH----------KIK 143
H + +T G V+ G GL R T + FFT++ K
Sbjct: 164 HAVAATASGIVFQWG------TGLASCGRRLCPGQTLPL--FFTAKEPSRVTGLENSKAM 215
Query: 144 QLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI----GKPVSWISCGY 199
+ AGS+ SA+LT+ G +++WG N GQ+ + + VPQ++ + V+ I G+
Sbjct: 216 CVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHCFQNEKVTAIWSGW 274
Query: 200 YHSAFVTTDGELYVFGEPENGKLGLP------------NQLLGNHRTPQLVSEIPEKVI- 246
H T G+++ +G + G+LG + L R P + P +
Sbjct: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
Query: 247 --QVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGE 304
+V+CG EH + + Y++G + G G GT PK ++ + + + CG
Sbjct: 335 ATEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEA-NVWAPKPVQALLSSSGLLVGCGA 393
Query: 305 NHTALITDI 313
H+ + +
Sbjct: 394 GHSLALCQL 402
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 118 bits (295), Expect = 3e-26
Identities = 84/310 (27%), Positives = 148/310 (47%), Gaps = 25/310 (8%)
Query: 43 GDEHSAVVTGNNKLYMF-----GSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
G+ H AVVT +LY + G+ GQLG G K++ +P V+ L+ + ++ +CG +
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDD 436
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFH--VISFFTSEHKIKQLSAGSNTSAAL 155
T+ T+ G +YA G + G +G+ ++FF S + ++Q+S G N L
Sbjct: 437 FTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLS-NPVEQVSCGDNHVVVL 495
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCGYYHSAFVTTDGELYV 213
T + ++ WG G++GL + + PQ+V + K + + CG + +T G++
Sbjct: 496 TRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLA 555
Query: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIP-------------EKVIQVACGGEHTVVLTE 260
G E KLGL NQ + + E+P K+ +A G HT + E
Sbjct: 556 CGLNEFNKLGL-NQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDE 614
Query: 261 NA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTF 319
+ TFG + GQLG+G + + + + + +SCG+ T TD ++ +
Sbjct: 615 RGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAW 674
Query: 320 GDGRHGKLGL 329
G+G +G+L +
Sbjct: 675 GNGGNGRLAM 684
Score = 98.2 bits (243), Expect = 3e-20
Identities = 79/289 (27%), Positives = 127/289 (43%), Gaps = 45/289 (15%)
Query: 30 FWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKV 89
F+ N V +SCGD H V+T N ++Y +G +G+LGL S+ P V K +
Sbjct: 476 FFLSNPVE-QVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALII 534
Query: 90 KLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTE----ERNTFHVISFFT-------- 137
CG + T + T+ G V A G N +LGL +H + + T
Sbjct: 535 VAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQL 594
Query: 138 SEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVS---NVCVPQQVTIGKPVSW 194
S +KI+ ++ G +AA+ E GRL +G N GQ+G+ N + + GK V
Sbjct: 595 SFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIR 654
Query: 195 ISCGYYHSAFVTTDGELYVFGEPENGKLGL---------------PNQLLGN-HRTPQLV 238
+SCG + T D ++ +G NG+L + P + G+ H P L
Sbjct: 655 VSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDL- 713
Query: 239 SEIPEKVIQVACGGEHTVVLTENAVYTFGL-GQFGQLGLGTFLFETSEP 286
+C G HT+++ E + + + L +GT +F++S P
Sbjct: 714 ----------SCRGWHTILIVEKVLNSKTIRSNSSGLSIGT-VFQSSSP 751
Score = 96.7 bits (239), Expect = 8e-20
Identities = 92/309 (29%), Positives = 149/309 (48%), Gaps = 42/309 (13%)
Query: 48 AVVTGN-NKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGG 106
AVVT +++Y++G G KS K +K+ + G H V T
Sbjct: 340 AVVTSRTSEVYVWG---------GGKSTPQKLDVIKS--GCSARQVCAGNTHFAVVTVEK 388
Query: 107 NVYA----TGGNN-EGQLGLGDTEE-RNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGR 160
+Y GG GQLG GD R HV I+Q+S G + + +T++G+
Sbjct: 389 ELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKL--QGKAIRQVSCGDDFTVCVTDEGQ 446
Query: 161 LFMWGDNSEGQIGLKNVSN--VCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFGE 216
L+ +G + G +G+ V+ V P Q+ + PV +SCG H +T + E+Y +G
Sbjct: 447 LYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGC 506
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVA--CGGEHTVVLTENA-VYTFGLGQFGQ 273
E G+LGL ++ ++ TPQ V ++P+ +I VA CG + T +LT++ V GL +F +
Sbjct: 507 GEYGRLGLDSE--EDYYTPQKV-DVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNK 563
Query: 274 LGLGTFLFE------------TSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGD 321
LGL + T+ + + + I I+ G+ HTA I + G + TFG
Sbjct: 564 LGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGC 623
Query: 322 GRHGKLGLG 330
+ G+LG+G
Sbjct: 624 NKCGQLGVG 632
Score = 86.7 bits (213), Expect = 8e-17
Identities = 68/260 (26%), Positives = 123/260 (47%), Gaps = 29/260 (11%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSA--ISKPTCVKALKPEKVKLAACGRN 97
+SCGD+ + VT +LY FGS+ +G +G+ + + +P + V+ +CG N
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDN 490
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
H +V T VY+ G G+LGL E+ T + I + G + + LT+
Sbjct: 491 HVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVD-VPKALIIVAVQCGCDGTFLLTQ 549
Query: 158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQV----------TIGKPVSW-----ISCGYYHS 202
G++ G N ++GL + + + T+ K +S+ I+ G H+
Sbjct: 550 SGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHT 609
Query: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI-----PEKVIQVACGGEHTVV 257
A + G L FG + G+LG +GN++ ++ + ++VI+V+CG E T+
Sbjct: 610 AAIDERGRLLTFGCNKCGQLG-----VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIA 664
Query: 258 LT-ENAVYTFGLGQFGQLGL 276
T +N ++ +G G G+L +
Sbjct: 665 ATDDNHIFAWGNGGNGRLAM 684
Score = 77.4 bits (189), Expect = 5e-14
Identities = 58/205 (28%), Positives = 97/205 (47%), Gaps = 21/205 (10%)
Query: 161 LFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVF-----G 215
+++WG L + + C +QV G H A VT + ELY + G
Sbjct: 349 VYVWGGGKSTPQKLDVIKSGCSARQVCAGNT---------HFAVVTVEKELYTWVNMQGG 399
Query: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT-ENAVYTFGLGQFGQ 273
+G+LG ++ ++R P+ V ++ K I QV+CG + TV +T E +Y FG +G
Sbjct: 400 TKLHGQLGHGDK--ASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGC 457
Query: 274 LGLGTFLF-ETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLE 332
+G+ E EP + + +SCG+NH ++T +Y++G G +G+LGL E
Sbjct: 458 MGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSE 517
Query: 333 NFTNHFIPTLCSNFLRFIVKLVACG 357
+++ P I+ V CG
Sbjct: 518 E--DYYTPQKVDVPKALIIVAVQCG 540
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/142 (32%), Positives = 67/142 (47%), Gaps = 9/142 (6%)
Query: 230 GNHRTPQLVSEIPE--KVIQVACGGEHTVVLT-ENAVYTF-----GLGQFGQLGLGTFLF 281
G TPQ + I QV G H V+T E +YT+ G GQLG G
Sbjct: 354 GGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKA- 412
Query: 282 ETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPT 341
+PK +E ++ + I +SCG++ T +TD G +Y FG +G +G+ P
Sbjct: 413 SYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPM 472
Query: 342 LCSNFLRFIVKLVACGGCHMVV 363
+ FL V+ V+CG H+VV
Sbjct: 473 QLNFFLSNPVEQVSCGDNHVVV 494
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 113 bits (283), Expect = 6e-25
Identities = 86/288 (29%), Positives = 139/288 (48%), Gaps = 19/288 (6%)
Query: 39 HLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNH 98
H++CGD +A +T + FGS + G LG GS + IS+PT V+AL ++ ACG +H
Sbjct: 395 HVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASH 454
Query: 99 TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
L + ++A G + G+LGLG E + + + + +++ G ++S LT
Sbjct: 455 VLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQ-EAQRVVCGIDSSMILTVP 513
Query: 159 GRLFMWGDNSEGQIGLKNVS--NVCVPQQ--------VTIG------KPVSWISCGYYHS 202
G+ G N ++GL ++S VP Q +G +P+ I G HS
Sbjct: 514 GQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHS 573
Query: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TEN 261
A VT G+ Y FG ++G+LG N G+ ++ K+ VACG TV + E+
Sbjct: 574 AAVTASGDCYTFGSNQHGQLG-TNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAES 632
Query: 262 AVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTAL 309
VY++G G G+LG P ++ T++ +SC +T L
Sbjct: 633 EVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLL 680
Score = 95.9 bits (237), Expect = 1e-19
Identities = 82/323 (25%), Positives = 136/323 (42%), Gaps = 35/323 (10%)
Query: 34 NDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPE------ 87
N V ++ G A VT + +L + W LG+ P V+ +P+
Sbjct: 331 NTEVVQVAAGRTQKAGVTRSGRLIL-----WEAPPLGAGGGSLLPGAVEQPQPQFISRFL 385
Query: 88 ------KVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHK 141
+K ACG T T+ G + G + G LG G + + ++ ++
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLG-YE 444
Query: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGY 199
+ Q++ G++ AL+ + LF WG G++GL + PQQV + G+ + CG
Sbjct: 445 MVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGI 504
Query: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQ----------LVSEIP---EKVI 246
S +T G+ G KLGL + LG P L+ P E ++
Sbjct: 505 DSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLL 564
Query: 247 QVACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGEN 305
+ G H+ +T + YTFG Q GQLG T + KV + + ++ ++CG+
Sbjct: 565 SIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKV-QGLEGIKMAMVACGDA 623
Query: 306 HTALITDIGLMYTFGDGRHGKLG 328
T I +Y++G G G+LG
Sbjct: 624 FTVAIGAESEVYSWGKGARGRLG 646
Score = 84.0 bits (206), Expect = 5e-16
Identities = 85/327 (25%), Positives = 139/327 (42%), Gaps = 37/327 (11%)
Query: 64 WGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATG----GNNEGQL 119
WG GLG+ P + L E V++AA GR T G + G G L
Sbjct: 317 WGG-GLGT------PLRLPMLNTEVVQVAA-GRTQKAGVTRSGRLILWEAPPLGAGGGSL 368
Query: 120 GLGDTEERNTFHVISFFTSEH--KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNV 177
G E+ + F + IK ++ G +A LT+ G + +G S G +G ++
Sbjct: 369 LPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSL 428
Query: 178 SNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTP 235
+++ P + +G + ++CG H ++T+ EL+ +G ++G+LGL + +H P
Sbjct: 429 TDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTR--ESHSCP 486
Query: 236 QLVSEIPEKVIQ-VACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
Q V P + Q V CG + +++LT G +F +LGL L EP + +
Sbjct: 487 QQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLD-HLSLGEEPVPHQQVE 545
Query: 294 D--------------QTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFI 339
+ + + I G H+A +T G YTFG +HG+LG +
Sbjct: 546 EALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSR--A 603
Query: 340 PTLCSNFLRFIVKLVACGGCHMVVFAA 366
P + +VACG V A
Sbjct: 604 PCKVQGLEGIKMAMVACGDAFTVAIGA 630
Score = 82.8 bits (203), Expect = 1e-15
Identities = 59/235 (25%), Positives = 108/235 (45%), Gaps = 15/235 (6%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
V ++CG H ++ +L+ +G + G+LGLG++ + S P V ++ + CG +
Sbjct: 446 VQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGID 505
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLG------------DTEERNTFHVI-SFFTSEHKIKQ 144
+++ T G A G N +LGL EE +F ++ S + +
Sbjct: 506 SSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLS 565
Query: 145 LSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKPVSWISCGYYHS 202
+ G+ SAA+T G + +G N GQ+G P +V G ++ ++CG +
Sbjct: 566 IDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFT 625
Query: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVV 257
+ + E+Y +G+ G+LG ++ G R QL P V V+C +T++
Sbjct: 626 VAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLL 680
Score = 60.1 bits (144), Expect = 8e-09
Identities = 51/187 (27%), Positives = 82/187 (43%), Gaps = 14/187 (7%)
Query: 195 ISCGYYHSAFVTTDGELYVFGEPENGKLG---LPNQLLGNHRTPQLVSEIPE-----KVI 246
++ G A VT G L ++ P G G LP + PQ +S E +
Sbjct: 337 VAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAV--EQPQPQFISRFLEGQSGVTIK 394
Query: 247 QVACGGEHTVVLTENAVY-TFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGEN 305
VACG T LT+ + TFG G G LG G+ L + S+P ++E + + ++CG +
Sbjct: 395 HVACGDFFTACLTDRGIIMTFGSGSNGCLGHGS-LTDISQPTIVEALLGYEMVQVACGAS 453
Query: 306 HTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
H ++ ++ +G G G+LGLG +H P + V CG ++
Sbjct: 454 HVLALSTERELFAWGRGDSGRLGLGTRE--SHSCPQQVPMPPGQEAQRVVCGIDSSMILT 511
Query: 366 APHRGVA 372
P + +A
Sbjct: 512 VPGQALA 518
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 97.4 bits (241), Expect = 5e-20
Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 40/323 (12%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
HS ++T KL+ +G N GQLG G + P ++ L E + AACGRNHTL TE
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G+V+A G N GQLGLG+ + + + I +++ G+ S + G L+ +G
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIMDCKGNLYSFG 279
Query: 166 DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
GQ+G + GK ++ Y V +++ + L +P
Sbjct: 280 CPEYGQLG-----------HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVP 328
Query: 226 NQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETS 284
N + V VACG HT+VL ++ V+++G G +G+LG E
Sbjct: 329 NVV----------------VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE-M 371
Query: 285 EPKVIE--NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
P++++ + + S I G + ++++G ++ +G + + P
Sbjct: 372 VPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKA 423
Query: 343 CSNFLRFIVKLVACGGCHMVVFA 365
+ + ++ +ACG ++V A
Sbjct: 424 VQDLCGWRIRSLACGKSSIIVAA 446
Score = 77.8 bits (190), Expect = 4e-14
Identities = 72/311 (23%), Positives = 136/311 (43%), Gaps = 46/311 (14%)
Query: 34 NDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKS-AISKPTCVKALKPEKVKLA 92
++V V +CG H+ +T ++ FG N GQLGLG+++ A+ P + + +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
Query: 93 ACGRNHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEH 140
ACG +++ GN+Y+ G GQLG +R + ++ F +
Sbjct: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
Query: 141 K-----------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI- 188
K ++ ++ G+N + L R+F WG G++G + VP+ V +
Sbjct: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
Query: 189 ---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI-PEK 244
G+ S I GY S V+ G L+ +G + + P+ V ++ +
Sbjct: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKAVQDLCGWR 431
Query: 245 VIQVACGGEHTVVLTENAVYTFGLG-QFGQLGLGTFLFETS----EPKVIENIRDQTISY 299
+ +ACG +V + + ++G FG+LG G ++S E K ++ I +
Sbjct: 432 IRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSE---Q 488
Query: 300 ISCGENHTALI 310
++ G +H+ +I
Sbjct: 489 VAMGYSHSLVI 499
Score = 72.4 bits (176), Expect = 2e-12
Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 58/299 (19%)
Query: 8 MPDSGAVFTFGKSKFAE----------NNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLY 57
+ ++G+VF FG++K + +P + + ++CG E S ++ LY
Sbjct: 217 LTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLY 276
Query: 58 MFGSNNWGQLGLGSKSA-ISKPTCVK---ALKPEKVKL--------------------AA 93
FG +GQLG S I++ ++ L P +V + A
Sbjct: 277 SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA 336
Query: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHK-IKQLSAGSNTS 152
CG NHTLV V++ G G+LG + ++ ++ F + Q+ AG S
Sbjct: 337 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 396
Query: 153 AALTEDGRLFMWG---DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDG 209
A++E G LF WG + E + K V ++C G + ++CG S V D
Sbjct: 397 FAVSEVGGLFFWGATNTSRESTMYPKAVQDLC-------GWRIRSLACG-KSSIIVAADE 448
Query: 210 ELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPEKVI------QVACGGEHTVVLTEN 261
+G P G+LG G+H+ + K + QVA G H++V+ +
Sbjct: 449 STISWGPSPTFGELG-----YGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 97.4 bits (241), Expect = 5e-20
Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 40/323 (12%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
HS ++T KL+ +G N GQLG G + P ++ L E + AACGRNHTL TE
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G+V+A G N GQLGLG+ + + + I +++ G+ S + G L+ +G
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIMDCKGNLYSFG 279
Query: 166 DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
GQ+G + GK ++ Y V +++ + L +P
Sbjct: 280 CPEYGQLG-----------HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVP 328
Query: 226 NQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETS 284
N + V VACG HT+VL ++ V+++G G +G+LG E
Sbjct: 329 NVV----------------VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE-M 371
Query: 285 EPKVIE--NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
P++++ + + S I G + ++++G ++ +G + + P
Sbjct: 372 VPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKA 423
Query: 343 CSNFLRFIVKLVACGGCHMVVFA 365
+ + ++ +ACG ++V A
Sbjct: 424 VQDLCGWRIRSLACGKSSIIVAA 446
Score = 77.8 bits (190), Expect = 4e-14
Identities = 72/311 (23%), Positives = 136/311 (43%), Gaps = 46/311 (14%)
Query: 34 NDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKS-AISKPTCVKALKPEKVKLA 92
++V V +CG H+ +T ++ FG N GQLGLG+++ A+ P + + +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
Query: 93 ACGRNHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEH 140
ACG +++ GN+Y+ G GQLG +R + ++ F +
Sbjct: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
Query: 141 K-----------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI- 188
K ++ ++ G+N + L R+F WG G++G + VP+ V +
Sbjct: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
Query: 189 ---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI-PEK 244
G+ S I GY S V+ G L+ +G + + P+ V ++ +
Sbjct: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKAVQDLCGWR 431
Query: 245 VIQVACGGEHTVVLTENAVYTFGLG-QFGQLGLGTFLFETS----EPKVIENIRDQTISY 299
+ +ACG +V + + ++G FG+LG G ++S E K ++ I +
Sbjct: 432 IRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSE---Q 488
Query: 300 ISCGENHTALI 310
++ G +H+ +I
Sbjct: 489 VAMGYSHSLVI 499
Score = 72.4 bits (176), Expect = 2e-12
Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 58/299 (19%)
Query: 8 MPDSGAVFTFGKSKFAE----------NNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLY 57
+ ++G+VF FG++K + +P + + ++CG E S ++ LY
Sbjct: 217 LTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLY 276
Query: 58 MFGSNNWGQLGLGSKSA-ISKPTCVK---ALKPEKVKL--------------------AA 93
FG +GQLG S I++ ++ L P +V + A
Sbjct: 277 SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA 336
Query: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHK-IKQLSAGSNTS 152
CG NHTLV V++ G G+LG + ++ ++ F + Q+ AG S
Sbjct: 337 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 396
Query: 153 AALTEDGRLFMWG---DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDG 209
A++E G LF WG + E + K V ++C G + ++CG S V D
Sbjct: 397 FAVSEVGGLFFWGATNTSRESTMYPKAVQDLC-------GWRIRSLACG-KSSIIVAADE 448
Query: 210 ELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPEKVI------QVACGGEHTVVLTEN 261
+G P G+LG G+H+ + K + QVA G H++V+ +
Sbjct: 449 STISWGPSPTFGELG-----YGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 82.4 bits (202), Expect = 2e-15
Identities = 86/308 (27%), Positives = 142/308 (46%), Gaps = 30/308 (9%)
Query: 78 PTCVKALKPEKVKL--AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTE-----ERNTF 130
P + +P++ ++ +CGR H+LV T+ V++ G N+ GQ G E E +
Sbjct: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222
Query: 131 HVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV---T 187
H + F + ++ Q++ G + S LT+ G ++ G ++GQ GL + + P ++
Sbjct: 223 HRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDL 280
Query: 188 IGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ 247
G V ++ V+ DG L+ +G E +L + L KV Q
Sbjct: 281 AGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQ 340
Query: 248 VACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVI--------ENIRDQTIS 298
ACGG VL E V+ +G +G LG G L E++ P++I E + +S
Sbjct: 341 AACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVS 397
Query: 299 YISCGENHTALITDIGLMYTFGDGRHGKLGLG-LENFTNHFIPTLCSNFLRFIVKLVACG 357
I CG +H A +T+ G ++ +G G LG+G LE+ + T+ + VACG
Sbjct: 398 RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVD-----VACG 452
Query: 358 GCHMVVFA 365
HMV A
Sbjct: 453 VDHMVTLA 460
Score = 80.9 bits (198), Expect = 4e-15
Identities = 76/293 (25%), Positives = 122/293 (41%), Gaps = 72/293 (24%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAA 93
+ +SCG HS V+T ++ G+N++GQ G + S+ V ++ +V A
Sbjct: 177 LQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVA 236
Query: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGL-------------GDTEERNTFHVISF----- 135
CG++H+L T+ G VY+ G +GQ GL GD N V ++
Sbjct: 237 CGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCL 296
Query: 136 -----------------------------------FTSEHKIKQLSAGSNTSAALTEDGR 160
F+ K++Q + G A L +G
Sbjct: 297 AVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGH 356
Query: 161 LFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSAFVTTDGE 210
+F+WG G+ N+ VP+ + T P VS I CG H A +T GE
Sbjct: 357 VFVWGYGILGK--GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGE 414
Query: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
L+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ +
Sbjct: 415 LFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 464
Score = 63.2 bits (152), Expect = 1e-09
Identities = 59/243 (24%), Positives = 109/243 (44%), Gaps = 39/243 (16%)
Query: 160 RLFMWGDNSEGQIGLKNVSNVC-----------------VPQQVTIGKPVSWISCGYYHS 202
R+F+WG + G +G+ + VP ++ + + +S +CGY +
Sbjct: 60 RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119
Query: 203 AFVTTDGEL---YVFGEPENGKLGLPNQLLGNHRTPQLVSE-----IP------EKVIQV 248
+ ++ + G ++ +LG R + V E +P +V+QV
Sbjct: 120 LLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQV 179
Query: 249 ACGGEHTVVLTEN-AVYTFGLGQFGQLGLGTFLFET-SEPKVIENIRD--QTISYISCGE 304
+CG H++VLT+ V++ G +GQ G E SE + ++D + ++CG+
Sbjct: 180 SCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
Query: 305 NHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLR--FIVKLVACGGCHMV 362
+H+ +TD G +Y+ G G G+ GLG N T+ PT L ++++ G C +
Sbjct: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS--PTKLGGDLAGVNVIQVATYGDCCLA 297
Query: 363 VFA 365
V A
Sbjct: 298 VSA 300
>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 77.4 bits (189), Expect = 5e-14
Identities = 69/240 (28%), Positives = 108/240 (45%), Gaps = 22/240 (9%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV--KALKPEKVKLAACG 95
V ++CG +HS +T ++Y G GQ GLG + S PT + +++A G
Sbjct: 36 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 95
Query: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153
VS +GG G N L L + +V F+ K++Q + G A
Sbjct: 96 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
Query: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203
L +G +F+WG G+ N+ VP+ + T P VS I CG A
Sbjct: 153 VLNGEGHVFVWGYGILGK--GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
Query: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
+T GEL+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ +
Sbjct: 211 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 267
Score = 61.2 bits (147), Expect = 4e-09
Identities = 75/272 (27%), Positives = 119/272 (43%), Gaps = 28/272 (10%)
Query: 112 GGNNEGQLGLGDTE-----ERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGD 166
G N+ GQ G E E + H + F + + Q++ G + S LT+ G ++ G
Sbjct: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ--VVQVACGQDHSLFLTDKGEVYSCGW 59
Query: 167 NSEGQIGLKNVSNVCVPQQV---TIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223
++GQ GL + + P ++ G V ++ V+ DG L+ +G E +L
Sbjct: 60 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
Query: 224 LPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFE 282
+ L KV Q ACGG VL E V+ +G +G LG G L E
Sbjct: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 176
Query: 283 TSEPKVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG-LEN 333
++ P++I E + +S I CG + A +T+ G ++ +G G LG+G LE+
Sbjct: 177 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLED 236
Query: 334 FTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
+ T+ + VACG HMV A
Sbjct: 237 QYFPWRVTMPGEPVD-----VACGVDHMVTLA 263
>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 77.4 bits (189), Expect = 5e-14
Identities = 69/240 (28%), Positives = 108/240 (45%), Gaps = 22/240 (9%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV--KALKPEKVKLAACG 95
V ++CG +HS +T ++Y G GQ GLG + S PT + +++A G
Sbjct: 36 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 95
Query: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153
VS +GG G N L L + +V F+ K++Q + G A
Sbjct: 96 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
Query: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203
L +G +F+WG G+ N+ VP+ + T P VS I CG A
Sbjct: 153 VLNGEGHVFVWGYGILGK--GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
Query: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
+T GEL+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ +
Sbjct: 211 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 267
Score = 61.2 bits (147), Expect = 4e-09
Identities = 75/272 (27%), Positives = 119/272 (43%), Gaps = 28/272 (10%)
Query: 112 GGNNEGQLGLGDTE-----ERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGD 166
G N+ GQ G E E + H + F + + Q++ G + S LT+ G ++ G
Sbjct: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ--VVQVACGQDHSLFLTDKGEVYSCGW 59
Query: 167 NSEGQIGLKNVSNVCVPQQV---TIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223
++GQ GL + + P ++ G V ++ V+ DG L+ +G E +L
Sbjct: 60 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
Query: 224 LPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFE 282
+ L KV Q ACGG VL E V+ +G +G LG G L E
Sbjct: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 176
Query: 283 TSEPKVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG-LEN 333
++ P++I E + +S I CG + A +T+ G ++ +G G LG+G LE+
Sbjct: 177 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLED 236
Query: 334 FTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
+ T+ + VACG HMV A
Sbjct: 237 QYFPWRVTMPGEPVD-----VACGVDHMVTLA 263
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 74.3 bits (181), Expect = 4e-13
Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 21/231 (9%)
Query: 139 EHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWIS 196
E + +QL G+ + L G++F WG GQ+G + P+ + G ++ ++
Sbjct: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
Query: 197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV 256
G +HS V+ G++Y++G E+G+L LP + L +E E V + A
Sbjct: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRNL---------AEDGETVAREA------T 261
Query: 257 VLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316
L E+ G F+ P +++ SCG HTA++T G +
Sbjct: 262 ELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGEL 321
Query: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFL--RFIVKLVACGGCHMVVFA 365
YT+G G++G+ LG E+ T+ P F+ + VK V CG + V+A
Sbjct: 322 YTWGWGKYGQ--LGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYA 370
Score = 63.5 bits (153), Expect = 7e-10
Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 22/223 (9%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
L G EH+ ++ +++ +G GQLG G+ A +P ++AL+ + A G H+
Sbjct: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159
+ +E G++Y G N GQL L + + + + + L EDG
Sbjct: 223 VCVSETGDIYIWGWNESGQLAL---------------PTRNLAEDGETVAREATELNEDG 267
Query: 160 RLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEP 217
+E ++ P + +G SCG H+A VT GELY +G
Sbjct: 268 SQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWG 327
Query: 218 ENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTVV 257
+ G+LG ++ + P+ V +K +Q V CG +T V
Sbjct: 328 KYGQLG--HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYV 368
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 5/130 (3%)
Query: 208 DGELYVFGEPENGKLGLPN--QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVL-TENAV 263
+GE GE + G+L L + + R P PE + Q+ G EH ++L V
Sbjct: 120 EGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQV 179
Query: 264 YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGR 323
+++G G+ GQLG GT E EP+++E ++ ++ ++ G H+ +++ G +Y +G
Sbjct: 180 FSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
Query: 324 HGKLGLGLEN 333
G+L L N
Sbjct: 239 SGQLALPTRN 248
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/66 (37%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKAL--KPEKVKLAACG 95
V SCG H+AVVT +LY +G +GQLG +++ +P V+ K +VK CG
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
Query: 96 RNHTLV 101
+T V
Sbjct: 363 PWNTYV 368
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 50/204 (24%)
Query: 7 LMPDSGAVFTFGKSKFAENNPGKFWFKND----------VPVHLSCGDEHSAVVTGNNKL 56
L+ +G VF++G + + G + + V ++ G HS V+ +
Sbjct: 172 LLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDI 231
Query: 57 YMFGSNNWGQLGLGSKSAISK----------------------------PTCVKALKPEK 88
Y++G N GQL L +++ P A++P
Sbjct: 232 YIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFP 291
Query: 89 VKL----------AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTS 138
L A+CG HT V T G +Y G GQLG DT + + +F
Sbjct: 292 ALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD 351
Query: 139 EH-KIKQLSAGS-NTSAALTEDGR 160
+ ++K ++ G NT E G+
Sbjct: 352 KQLQVKAVTCGPWNTYVYAVEKGK 375
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 74.3 bits (181), Expect = 4e-13
Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 21/231 (9%)
Query: 139 EHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWIS 196
E + +QL G+ + L G++F WG GQ+G + P+ + G ++ ++
Sbjct: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
Query: 197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV 256
G +HS V+ G++Y++G E+G+L LP + L +E E V + A
Sbjct: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRNL---------AEDGETVAREA------T 261
Query: 257 VLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316
L E+ G F+ P +++ SCG HTA++T G +
Sbjct: 262 ELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGEL 321
Query: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFL--RFIVKLVACGGCHMVVFA 365
YT+G G++G+ LG E+ T+ P F+ + VK V CG + V+A
Sbjct: 322 YTWGWGKYGQ--LGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYA 370
Score = 63.5 bits (153), Expect = 7e-10
Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 22/223 (9%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
L G EH+ ++ +++ +G GQLG G+ A +P ++AL+ + A G H+
Sbjct: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159
+ +E G++Y G N GQL L + + + + + L EDG
Sbjct: 223 VCVSETGDIYIWGWNESGQLAL---------------PTRNLAEDGETVAREATELNEDG 267
Query: 160 RLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEP 217
+E ++ P + +G SCG H+A VT GELY +G
Sbjct: 268 SQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWG 327
Query: 218 ENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTVV 257
+ G+LG ++ + P+ V +K +Q V CG +T V
Sbjct: 328 KYGQLG--HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYV 368
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 5/130 (3%)
Query: 208 DGELYVFGEPENGKLGLPN--QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVL-TENAV 263
+GE GE + G+L L + + R P PE + Q+ G EH ++L V
Sbjct: 120 EGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQV 179
Query: 264 YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGR 323
+++G G+ GQLG GT E EP+++E ++ ++ ++ G H+ +++ G +Y +G
Sbjct: 180 FSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
Query: 324 HGKLGLGLEN 333
G+L L N
Sbjct: 239 SGQLALPTRN 248
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/66 (37%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKAL--KPEKVKLAACG 95
V SCG H+AVVT +LY +G +GQLG +++ +P V+ K +VK CG
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
Query: 96 RNHTLV 101
+T V
Sbjct: 363 PWNTYV 368
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 50/204 (24%)
Query: 7 LMPDSGAVFTFGKSKFAENNPGKFWFKND----------VPVHLSCGDEHSAVVTGNNKL 56
L+ +G VF++G + + G + + V ++ G HS V+ +
Sbjct: 172 LLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDI 231
Query: 57 YMFGSNNWGQLGLGSKSAISK----------------------------PTCVKALKPEK 88
Y++G N GQL L +++ P A++P
Sbjct: 232 YIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFP 291
Query: 89 VKL----------AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTS 138
L A+CG HT V T G +Y G GQLG DT + + +F
Sbjct: 292 ALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD 351
Query: 139 EH-KIKQLSAGS-NTSAALTEDGR 160
+ ++K ++ G NT E G+
Sbjct: 352 KQLQVKAVTCGPWNTYVYAVEKGK 375
>gi|209364523 alsin isoform 2 [Homo sapiens]
Length = 396
Score = 73.6 bits (179), Expect = 7e-13
Identities = 44/173 (25%), Positives = 88/173 (50%), Gaps = 9/173 (5%)
Query: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYH 201
+ Q + G LTEDG ++ +G ++ + + + +G+ V ++ G +H
Sbjct: 43 VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFH 102
Query: 202 SAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE------IPEKVIQVACGGEHT 255
S VT +G Y++GE G+ + NQ P +++ + +++Q+ACG EHT
Sbjct: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162
Query: 256 VVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
+ L+ ++ +G G QLGL T F ++P+ +E++ + + ++CG H+
Sbjct: 163 LALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
Score = 58.2 bits (139), Expect = 3e-08
Identities = 49/179 (27%), Positives = 82/179 (45%), Gaps = 16/179 (8%)
Query: 92 AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNT 151
AA G H ++ TE G VY+ G G E + ++ + ++ GS
Sbjct: 46 AALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSFH 102
Query: 152 SAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP---------VSWISCGYYHS 202
S A+T++G +MWG+NS GQ + N V P V+I + ++CG H+
Sbjct: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162
Query: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLTE 260
++ E++ +G +LGL + PQ V + +V+ QVACG H++ L +
Sbjct: 163 LALSISREIWAWG--TGCQLGLITTAFPVTK-PQKVEHLAGRVVLQVACGAFHSLALVQ 218
Score = 45.4 bits (106), Expect = 2e-04
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 25/170 (14%)
Query: 7 LMPDSGAVFTFG----KSKFAENNPGKFWFKNDVP----VHLSCGDEHSAVVTGNNKLYM 58
L+ + G V++FG +S E P +N + + ++ G HS VT N YM
Sbjct: 55 LLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYM 114
Query: 59 FGSNNWGQLGLGSKSAISKPTCVKALKPE-------KVKLAACGRNHTLVSTEGGNVYAT 111
+G N+ GQ + ++ + +P V E ++ ACG HTL + ++A
Sbjct: 115 WGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAW 174
Query: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEH----KIKQLSAGSNTSAALTE 157
G QLGL T F V EH + Q++ G+ S AL +
Sbjct: 175 G--TGCQLGLITT----AFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 73.6 bits (179), Expect = 7e-13
Identities = 44/173 (25%), Positives = 88/173 (50%), Gaps = 9/173 (5%)
Query: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYH 201
+ Q + G LTEDG ++ +G ++ + + + +G+ V ++ G +H
Sbjct: 43 VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFH 102
Query: 202 SAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE------IPEKVIQVACGGEHT 255
S VT +G Y++GE G+ + NQ P +++ + +++Q+ACG EHT
Sbjct: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162
Query: 256 VVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
+ L+ ++ +G G QLGL T F ++P+ +E++ + + ++CG H+
Sbjct: 163 LALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
Score = 58.2 bits (139), Expect = 3e-08
Identities = 49/179 (27%), Positives = 82/179 (45%), Gaps = 16/179 (8%)
Query: 92 AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNT 151
AA G H ++ TE G VY+ G G E + ++ + ++ GS
Sbjct: 46 AALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSFH 102
Query: 152 SAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP---------VSWISCGYYHS 202
S A+T++G +MWG+NS GQ + N V P V+I + ++CG H+
Sbjct: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162
Query: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLTE 260
++ E++ +G +LGL + PQ V + +V+ QVACG H++ L +
Sbjct: 163 LALSISREIWAWG--TGCQLGLITTAFPVTK-PQKVEHLAGRVVLQVACGAFHSLALVQ 218
Score = 49.7 bits (117), Expect = 1e-05
Identities = 69/284 (24%), Positives = 119/284 (41%), Gaps = 26/284 (9%)
Query: 43 GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102
G+ + + + +++ +G GQLG G +P CVK L ++V G H+L
Sbjct: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLAL 574
Query: 103 TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL--TEDGR 160
T VY+ G N GQLG D T ++ +SE+ + ++AG + S L TED +
Sbjct: 575 TAKSQVYSWGSNTFGQLGHSDFP--TTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
Query: 161 --LFMWG--DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGE 216
L+ G D +EG +N S P ++ K GY D L + +
Sbjct: 633 PGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSK------LGYISRVTAGKDSYLALVDK 686
Query: 217 PENGKLGLPNQLLGNHRT-PQLVSEIPEKVIQVACGGEH-----TVVLTENAVYTFG--- 267
G + ++L R +S+I ++++ E+ TV L + F
Sbjct: 687 NIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFSKLC 746
Query: 268 --LGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTAL 309
+GQ G L +FL E + + ++ ++ S E T++
Sbjct: 747 YLIGQHG-ASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSI 789
Score = 45.4 bits (106), Expect = 2e-04
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 25/170 (14%)
Query: 7 LMPDSGAVFTFG----KSKFAENNPGKFWFKNDVP----VHLSCGDEHSAVVTGNNKLYM 58
L+ + G V++FG +S E P +N + + ++ G HS VT N YM
Sbjct: 55 LLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYM 114
Query: 59 FGSNNWGQLGLGSKSAISKPTCVKALKPE-------KVKLAACGRNHTLVSTEGGNVYAT 111
+G N+ GQ + ++ + +P V E ++ ACG HTL + ++A
Sbjct: 115 WGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAW 174
Query: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEH----KIKQLSAGSNTSAALTE 157
G QLGL T F V EH + Q++ G+ S AL +
Sbjct: 175 G--TGCQLGLITT----AFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
Score = 40.4 bits (93), Expect = 0.007
Identities = 25/69 (36%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
+HL G HS +T +++Y +GSN +GQLG S + P K V A GR+
Sbjct: 562 IHLEAGGYHSLALTAKSQVYSWGSNTFGQLG-HSDFPTTVPRLAKISSENGVWSIAAGRD 620
Query: 98 HT--LVSTE 104
++ LV TE
Sbjct: 621 YSLFLVDTE 629
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 67.8 bits (164), Expect = 4e-11
Identities = 48/170 (28%), Positives = 84/170 (49%), Gaps = 10/170 (5%)
Query: 149 SNTSAALTE---DGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKPVSWISCGYYHSA 203
S+ A LT+ G +F WGD G++G +PQ + G+ V I CG
Sbjct: 662 SDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLL 721
Query: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTV-VLTEN 261
+T G ++ +G+ + +LG + + + R PQ+V + +K++ VA G +H + V+
Sbjct: 722 ALTKSGVVWTWGKGDYFRLGHRSDV--HVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSG 779
Query: 262 AVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALIT 311
VY +G GQ G GT +P +++ + Q I ++CG +H+ T
Sbjct: 780 QVYAWGDNDHGQQGNGTTTV-NRKPMLVQGLEGQKIMCVACGSSHSVAWT 828
Score = 67.4 bits (163), Expect = 5e-11
Identities = 49/164 (29%), Positives = 82/164 (50%), Gaps = 6/164 (3%)
Query: 105 GGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMW 164
GG V++ G + G+LG G +E N I + + Q+ G+ ALT+ G ++ W
Sbjct: 674 GGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-VCQIECGAQFLLALTKSGVVWTW 732
Query: 165 GDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
G ++G ++ +V PQ V GK + ++ G H V G++Y +G+ ++G+
Sbjct: 733 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 223 GLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAVYT 265
G N +R P LV + +K++ VACG H+V T V T
Sbjct: 793 G--NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVAT 834
Score = 66.2 bits (160), Expect = 1e-10
Identities = 45/158 (28%), Positives = 78/158 (49%), Gaps = 7/158 (4%)
Query: 209 GELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAV-YTF 266
G ++ +G+ + GKLG N PQ + + + V Q+ CG + + LT++ V +T+
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCN--IPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 732
Query: 267 GLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGK 326
G G + +LG + + +P+V+E +R + I +++ G H + D G +Y +GD HG+
Sbjct: 733 GKGDYFRLGHRSDV-HVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 791
Query: 327 LGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVF 364
G G P L + VACG H V +
Sbjct: 792 QGNGTTTVNRK--PMLVQGLEGQKIMCVACGSSHSVAW 827
Score = 57.8 bits (138), Expect = 4e-08
Identities = 42/158 (26%), Positives = 71/158 (44%), Gaps = 11/158 (6%)
Query: 56 LYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNN 115
++ +G ++G+LG G + P ++ L + V CG L T+ G V+ G +
Sbjct: 677 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 736
Query: 116 EGQLGLGDTEERNTFHVISFFTSE----HKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQ 171
+LG R+ HV E KI ++ G+ A+ + G+++ WGDN GQ
Sbjct: 737 YFRLG-----HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 791
Query: 172 --IGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTT 207
G V+ + Q G+ + ++CG HS TT
Sbjct: 792 QGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 829
Score = 56.2 bits (134), Expect = 1e-07
Identities = 43/155 (27%), Positives = 69/155 (44%), Gaps = 11/155 (7%)
Query: 12 GAVFTFGKSKFAE---------NNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLYMFGS 61
G VF++G F + N P N V + CG + +T + ++ +G
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734
Query: 62 NNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGL 121
++ +LG S + KP V+ L+ +K+ A G H L + G VYA G N+ GQ G
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 794
Query: 122 GDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
G T ++ + KI ++ GS+ S A T
Sbjct: 795 GTTTVNRKPMLVQGLEGQ-KIMCVACGSSHSVAWT 828
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,144,761
Number of Sequences: 37866
Number of extensions: 1536230
Number of successful extensions: 7879
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 106
Number of HSP's successfully gapped in prelim test: 503
Number of HSP's that attempted gapping in prelim test: 5108
Number of HSP's gapped (non-prelim): 1717
length of query: 815
length of database: 18,247,518
effective HSP length: 111
effective length of query: 704
effective length of database: 14,044,392
effective search space: 9887251968
effective search space used: 9887251968
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.