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Search of human proteins with 4505257
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505257 moesin [Homo sapiens]
(577 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505257 moesin [Homo sapiens] 1134 0.0
gi|4506467 radixin [Homo sapiens] 948 0.0
gi|161702986 ezrin [Homo sapiens] 860 0.0
gi|21614499 ezrin [Homo sapiens] 860 0.0
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 503 e-142
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 496 e-140
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 496 e-140
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 496 e-140
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 432 e-121
gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens] 424 e-119
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens] 376 e-104
gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens] 376 e-104
gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens] 166 4e-41
gi|150010540 FERM domain containing 4B [Homo sapiens] 152 6e-37
gi|116063562 FERM domain containing 4A [Homo sapiens] 152 1e-36
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 146 4e-35
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 145 1e-34
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 142 1e-33
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 139 7e-33
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 139 9e-33
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 139 9e-33
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 139 9e-33
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 139 9e-33
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 138 2e-32
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 137 2e-32
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 135 8e-32
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 135 8e-32
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 135 1e-31
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 129 7e-30
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 127 2e-29
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 1134 bits (2933), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK
Sbjct: 1 MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
Query: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE
Sbjct: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
Query: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR
Sbjct: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
Query: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF
Sbjct: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK 360
EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK
Sbjct: 301 EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK 360
Query: 361 AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE 420
AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE
Sbjct: 361 AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE 420
Query: 421 MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQ 480
MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQ
Sbjct: 421 MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQ 480
Query: 481 DEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTA 540
DEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTA
Sbjct: 481 DEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTA 540
Query: 541 NDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 577
NDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM
Sbjct: 541 NDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 577
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 948 bits (2451), Expect = 0.0
Identities = 472/583 (80%), Positives = 523/583 (89%), Gaps = 6/583 (1%)
Query: 1 MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
MPK I+VRVTTMDAELEFAIQPNTTGKQLFDQVVKT+GLREVWFFGLQY D+KG+STWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
Query: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
LNKKVT QDV+KE+PL FKFRAKF+PEDVSEELIQ+ITQRLFFLQVKE ILND+IYCPPE
Sbjct: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
Query: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
TAVLLASYAVQ+KYGD+NKE+HK GYLA D+LLPQRVLEQHKL K+QWEERIQ WHEEHR
Sbjct: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
Query: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
GMLRED+++EYLKIAQDLEMYGVNYF IKNKKG+ELWLGVDALGLNIYE +D+LTPKIGF
Sbjct: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK 360
EVQQMKAQAREEKHQKQ+ERA LENEKKKRE+AEKEKE+IEREKEELMERLKQIEEQT K
Sbjct: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
Query: 361 AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE 420
AQ+ELEEQTR+ALEL+QERKRA+ EAE+L KER+ AEEAK A+ + + DQ K QEQLA E
Sbjct: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
Query: 421 MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMST------PHVAE 474
+AE TA+I+ LE A++KKE EA EWQ KA QEDLEKT+ ELKT MS P V
Sbjct: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
Query: 475 PAENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARD 534
P ENE DE DEN AEASA+L + + RSEEER TE +KNERV+K L+AL+SELA ARD
Sbjct: 481 PTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARD 540
Query: 535 ESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 577
E+KKT ND++HAEN++ GRDKYKTLRQIRQGNTKQRIDEFE+M
Sbjct: 541 ETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 860 bits (2222), Expect = 0.0
Identities = 428/586 (73%), Positives = 502/586 (85%), Gaps = 9/586 (1%)
Query: 1 MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
MPK I+VRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVW+FGL Y D KGF TWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
Query: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
L+KKV+AQ+VRKE+PL FKFRAKFYPEDV+EELIQDITQ+LFFLQVKEGIL+D+IYCPPE
Sbjct: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
Query: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
TAVLL SYAVQ+K+GD+NKEVHKSGYL+ ++L+PQRV++QHKL +DQWE+RIQVWH EHR
Sbjct: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
Query: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
GML+++A+LEYLKIAQDLEMYG+NYF IKNKKG++LWLGVDALGLNIYE++D+LTPKIGF
Sbjct: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRIL LCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK 360
EVQQMKAQAREEKHQKQ+ER LE EKK+RE E+EKE++ REKEELM RL+ EE+TKK
Sbjct: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
Query: 361 AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE 420
A++EL EQ +RAL+LE+ERKRAQ EAE+L +R A AKE L + + DQ K+QEQLA E
Sbjct: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
Query: 421 MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENE- 479
+AE TA+I+ LE AR++KE E EWQ +A+ Q+DL KT+ EL M+ P P E
Sbjct: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
Query: 480 -----QDEQDENGAEA---SADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELAN 531
Q+ + GAE SA+L ++ + DR+EE+R TEAEKNERVQ+ L L+SEL+
Sbjct: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
Query: 532 ARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 577
ARDE+K+T ND+IH ENMR GRDKYKTLRQIRQGNTKQRIDEFE++
Sbjct: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 860 bits (2222), Expect = 0.0
Identities = 428/586 (73%), Positives = 502/586 (85%), Gaps = 9/586 (1%)
Query: 1 MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
MPK I+VRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVW+FGL Y D KGF TWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
Query: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
L+KKV+AQ+VRKE+PL FKFRAKFYPEDV+EELIQDITQ+LFFLQVKEGIL+D+IYCPPE
Sbjct: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
Query: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
TAVLL SYAVQ+K+GD+NKEVHKSGYL+ ++L+PQRV++QHKL +DQWE+RIQVWH EHR
Sbjct: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
Query: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
GML+++A+LEYLKIAQDLEMYG+NYF IKNKKG++LWLGVDALGLNIYE++D+LTPKIGF
Sbjct: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRIL LCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK 360
EVQQMKAQAREEKHQKQ+ER LE EKK+RE E+EKE++ REKEELM RL+ EE+TKK
Sbjct: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
Query: 361 AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE 420
A++EL EQ +RAL+LE+ERKRAQ EAE+L +R A AKE L + + DQ K+QEQLA E
Sbjct: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
Query: 421 MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENE- 479
+AE TA+I+ LE AR++KE E EWQ +A+ Q+DL KT+ EL M+ P P E
Sbjct: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
Query: 480 -----QDEQDENGAEA---SADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELAN 531
Q+ + GAE SA+L ++ + DR+EE+R TEAEKNERVQ+ L L+SEL+
Sbjct: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
Query: 532 ARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 577
ARDE+K+T ND+IH ENMR GRDKYKTLRQIRQGNTKQRIDEFE++
Sbjct: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 503 bits (1296), Expect = e-142
Identities = 272/585 (46%), Positives = 386/585 (65%), Gaps = 17/585 (2%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
PKT +VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
+KKV DV KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL++ IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
+VLLASYAVQ+KYGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
R++A +EYLKIAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
VQQMKAQAREEK +KQMER L EK+ RE AE+ ++++ER RL Q++E+ A
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMA 370
Query: 362 QQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLA 418
+ L A L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ
Sbjct: 371 NEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKV 430
Query: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAE 477
LE L ++++ R K+ + + Q+A+ + ++ E+ T + P + PA
Sbjct: 431 LEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
Query: 478 NEQDEQDEN--GAEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANAR 533
D N G S D + M + E+E+ EK++ +Q+ L L +E+ +
Sbjct: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
Query: 534 DESKKTANDMIHAENM-RLGRDKYKTLRQIRQGNTKQRIDEFESM 577
+ ++TA D++H EN R G K+ T++++ + K R+ FE +
Sbjct: 551 LKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL 595
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 496 bits (1277), Expect = e-140
Identities = 268/569 (47%), Positives = 378/569 (66%), Gaps = 17/569 (2%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
PKT +VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
+KKV DV KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL++ IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
+VLLASYAVQ+KYGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
R++A +EYLKIAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
VQQMKAQAREEK +KQMER L EK+ RE AE+ ++++ER RL Q++E+ A
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMA 370
Query: 362 QQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLA 418
+ L A L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ
Sbjct: 371 NEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKV 430
Query: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAE 477
LE L ++++ R K+ + + Q+A+ + ++ E+ T + P + PA
Sbjct: 431 LEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
Query: 478 NEQDEQDEN--GAEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANAR 533
D N G S D + M + E+E+ EK++ +Q+ L L +E+ +
Sbjct: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
Query: 534 DESKKTANDMIHAENM-RLGRDKYKTLRQ 561
+ ++TA D++H EN R G K+ T+++
Sbjct: 551 LKERETALDILHNENSDRGGSSKHNTIKK 579
Score = 33.5 bits (75), Expect = 0.55
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 315 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 368
Query: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 369 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 422
Query: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
+ ++ AE + L + R KQ + E
Sbjct: 423 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 460
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 496 bits (1277), Expect = e-140
Identities = 268/569 (47%), Positives = 378/569 (66%), Gaps = 17/569 (2%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
PKT +VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
+KKV DV KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL++ IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
+VLLASYAVQ+KYGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
R++A +EYLKIAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
VQQMKAQAREEK +KQMER L EK+ RE AE+ ++++ER RL Q++E+ A
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMA 370
Query: 362 QQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLA 418
+ L A L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ
Sbjct: 371 NEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKV 430
Query: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAE 477
LE L ++++ R K+ + + Q+A+ + ++ E+ T + P + PA
Sbjct: 431 LEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
Query: 478 NEQDEQDEN--GAEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANAR 533
D N G S D + M + E+E+ EK++ +Q+ L L +E+ +
Sbjct: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
Query: 534 DESKKTANDMIHAENM-RLGRDKYKTLRQ 561
+ ++TA D++H EN R G K+ T+++
Sbjct: 551 LKERETALDILHNENSDRGGSSKHNTIKK 579
Score = 33.5 bits (75), Expect = 0.55
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 315 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 368
Query: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 369 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 422
Query: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
+ ++ AE + L + R KQ + E
Sbjct: 423 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 460
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 496 bits (1277), Expect = e-140
Identities = 268/569 (47%), Positives = 378/569 (66%), Gaps = 17/569 (2%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
PKT +VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
+KKV DV KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL++ IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
+VLLASYAVQ+KYGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
R++A +EYLKIAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
VQQMKAQAREEK +KQMER L EK+ RE AE+ ++++ER RL Q++E+ A
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMA 370
Query: 362 QQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLA 418
+ L A L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ
Sbjct: 371 NEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKV 430
Query: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAE 477
LE L ++++ R K+ + + Q+A+ + ++ E+ T + P + PA
Sbjct: 431 LEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
Query: 478 NEQDEQDEN--GAEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANAR 533
D N G S D + M + E+E+ EK++ +Q+ L L +E+ +
Sbjct: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
Query: 534 DESKKTANDMIHAENM-RLGRDKYKTLRQ 561
+ ++TA D++H EN R G K+ T+++
Sbjct: 551 LKERETALDILHNENSDRGGSSKHNTIKK 579
Score = 33.5 bits (75), Expect = 0.55
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 315 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 368
Query: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 369 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 422
Query: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
+ ++ AE + L + R KQ + E
Sbjct: 423 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 460
>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
Length = 548
Score = 432 bits (1112), Expect = e-121
Identities = 245/569 (43%), Positives = 351/569 (61%), Gaps = 59/569 (10%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
PKT +VR+ TMDAE+EF
Sbjct: 19 PKTFTVRIVTMDAEMEF------------------------------------------- 35
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
N +V DV KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL++ IYCPPE
Sbjct: 36 NCEVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 95
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
+VLLASYAVQ+KYGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG
Sbjct: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
R++A +EYLKIAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FP
Sbjct: 156 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 215
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 216 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 275
Query: 302 VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
VQQMKAQAREEK +KQMER L EK+ RE AE+ ++++ER RL Q++E+ A
Sbjct: 276 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMA 328
Query: 362 QQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLA 418
+ L A L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ
Sbjct: 329 NEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKV 388
Query: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAE 477
LE L ++++ R K+ + + Q+A+ + ++ E+ T + P + PA
Sbjct: 389 LEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 448
Query: 478 NEQDEQDEN--GAEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANAR 533
D N G S D + M + E+E+ EK++ +Q+ L L +E+ +
Sbjct: 449 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 508
Query: 534 DESKKTANDMIHAENM-RLGRDKYKTLRQ 561
+ ++TA D++H EN R G K+ T+++
Sbjct: 509 LKERETALDILHNENSDRGGSSKHNTIKK 537
Score = 33.5 bits (75), Expect = 0.55
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 273 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 326
Query: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 327 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 380
Query: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
+ ++ AE + L + R KQ + E
Sbjct: 381 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 418
>gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]
Length = 549
Score = 424 bits (1091), Expect = e-119
Identities = 242/569 (42%), Positives = 348/569 (61%), Gaps = 58/569 (10%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
PKT +VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
+KKV K+ IL++ IYCPPE
Sbjct: 78 DKKV-----------------------------------------KKQILDEKIYCPPEA 96
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
+VLLASYAVQ+KYGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG
Sbjct: 97 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 156
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
R++A +EYLKIAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FP
Sbjct: 157 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 216
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 217 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 276
Query: 302 VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
VQQMKAQAREEK +KQMER L EK+ RE AE+ ++++ER RL Q++E+ A
Sbjct: 277 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMA 329
Query: 362 QQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLA 418
+ L A L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ
Sbjct: 330 NEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKV 389
Query: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAE 477
LE L ++++ R K+ + + Q+A+ + ++ E+ T + P + PA
Sbjct: 390 LEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 449
Query: 478 NEQDEQDEN--GAEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANAR 533
D N G S D + M + E+E+ EK++ +Q+ L L +E+ +
Sbjct: 450 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 509
Query: 534 DESKKTANDMIHAENM-RLGRDKYKTLRQ 561
+ ++TA D++H EN R G K+ T+++
Sbjct: 510 LKERETALDILHNENSDRGGSSKHNTIKK 538
Score = 33.5 bits (75), Expect = 0.55
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 274 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 327
Query: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 328 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 381
Query: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
+ ++ AE + L + R KQ + E
Sbjct: 382 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 419
>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 376 bits (966), Expect = e-104
Identities = 210/497 (42%), Positives = 316/497 (63%), Gaps = 16/497 (3%)
Query: 74 SPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSK 133
S + F + P+ + ++ + F +VK+ IL++ IYCPPE +VLLASYAVQ+K
Sbjct: 7 SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAK 66
Query: 134 YGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLK 193
YGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG R++A +EYLK
Sbjct: 67 YGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLK 126
Query: 194 IAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDK 253
IAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FPW+EIRNIS++DK
Sbjct: 127 IAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDK 186
Query: 254 KFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEK 313
+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++EVQQMKAQAREEK
Sbjct: 187 EFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEK 246
Query: 314 HQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRAL 373
+KQMER L EK+ RE AE+ ++++ER RL Q++E+ A + L A
Sbjct: 247 ARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMANEALMRSEETAD 299
Query: 374 ELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLALEMAELTARISQ 430
L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ LE L ++++
Sbjct: 300 LLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAE 359
Query: 431 LEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAENEQDEQDEN--G 487
R K+ + + Q+A+ + ++ E+ T + P + PA D N G
Sbjct: 360 ESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIG 419
Query: 488 AEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIH 545
S D + M + E+E+ EK++ +Q+ L L +E+ + + ++TA D++H
Sbjct: 420 DSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILH 479
Query: 546 AENM-RLGRDKYKTLRQ 561
EN R G K+ T+++
Sbjct: 480 NENSDRGGSSKHNTIKK 496
Score = 33.5 bits (75), Expect = 0.55
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 232 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 285
Query: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 286 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 339
Query: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
+ ++ AE + L + R KQ + E
Sbjct: 340 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 377
Score = 32.3 bits (72), Expect = 1.2
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 3/33 (9%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
PKT +VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
>gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 376 bits (966), Expect = e-104
Identities = 210/497 (42%), Positives = 316/497 (63%), Gaps = 16/497 (3%)
Query: 74 SPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSK 133
S + F + P+ + ++ + F +VK+ IL++ IYCPPE +VLLASYAVQ+K
Sbjct: 7 SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAK 66
Query: 134 YGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLK 193
YGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG R++A +EYLK
Sbjct: 67 YGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLK 126
Query: 194 IAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDK 253
IAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FPW+EIRNIS++DK
Sbjct: 127 IAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDK 186
Query: 254 KFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEK 313
+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++EVQQMKAQAREEK
Sbjct: 187 EFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEK 246
Query: 314 HQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRAL 373
+KQMER L EK+ RE AE+ ++++ER RL Q++E+ A + L A
Sbjct: 247 ARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMANEALMRSEETAD 299
Query: 374 ELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLALEMAELTARISQ 430
L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ LE L ++++
Sbjct: 300 LLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAE 359
Query: 431 LEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAENEQDEQDEN--G 487
R K+ + + Q+A+ + ++ E+ T + P + PA D N G
Sbjct: 360 ESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIG 419
Query: 488 AEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIH 545
S D + M + E+E+ EK++ +Q+ L L +E+ + + ++TA D++H
Sbjct: 420 DSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILH 479
Query: 546 AENM-RLGRDKYKTLRQ 561
EN R G K+ T+++
Sbjct: 480 NENSDRGGSSKHNTIKK 496
Score = 33.5 bits (75), Expect = 0.55
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 232 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 285
Query: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 286 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 339
Query: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
+ ++ AE + L + R KQ + E
Sbjct: 340 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 377
Score = 32.3 bits (72), Expect = 1.2
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 3/33 (9%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
PKT +VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
>gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens]
Length = 165
Score = 166 bits (421), Expect = 4e-41
Identities = 82/132 (62%), Positives = 99/132 (75%), Gaps = 1/132 (0%)
Query: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
PKT +VR+ TMDAE+EF + GK LFD V +T+GLRE WFFGLQY K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
+KKV DV KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL++ IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLASYAVQSK 133
+VLLASYAVQ+K
Sbjct: 138 SVLLASYAVQAK 149
>gi|150010540 FERM domain containing 4B [Homo sapiens]
Length = 1034
Score = 152 bits (385), Expect = 6e-37
Identities = 144/606 (23%), Positives = 255/606 (42%), Gaps = 67/606 (11%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDV-R 71
D LE +QP ++L D V L+E +FG+ + D G WL+L+ +V D+ +
Sbjct: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPK 127
Query: 72 KESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQ 131
K P + F +FY E +S L T LFFL K + I ET LA++ +Q
Sbjct: 128 KPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQ 186
Query: 132 SKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEY 191
GD+ + + L P + L++H + E+R+ + + +G+ R AV++Y
Sbjct: 187 EAKGDYTSDENARKDLKTLPAFPTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQY 245
Query: 192 LKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFN 251
+KI + L YGV+Y+++K+K+G WLG+ G+ Y+ D++ P+ F W ++ N+ F
Sbjct: 246 MKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFR 305
Query: 252 DKKFVIKPIDKKAPDF-------------VFYAPRLRINKRILALCMGNHELYMRRRK-- 296
+KKF ++ D + +YA I K I + + H+ Y+ R++
Sbjct: 306 EKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLI-KSIWVMAISQHQFYLDRKQSK 364
Query: 297 ---PDTIEVQQMKAQAREEKHQKQMERAMLE-----------------------NEKKKR 330
P + ++ E Q+ + LE +E++KR
Sbjct: 365 AKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQKR 424
Query: 331 E--MAEKEKEKIEREKEELMERLKQIEEQTKKAQQELE-------EQTRRALELEQERKR 381
E + K+KEK+ +EK LK++EE K +E E E E + +R
Sbjct: 425 EKILELKKKEKLLQEK-----LLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRR 479
Query: 382 AQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESE 441
A KL +EE + LQ Q++L +L + ++K++ +
Sbjct: 480 RVGTAFKLDDNLLPSEE--DPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQD 537
Query: 442 AVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQDEQDENGAEASADLRADAMAK 501
+ +K Q ++ + + R S P + E + D +DA
Sbjct: 538 YTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFT- 596
Query: 502 DRSEEERTTEAEKNERVQKHLKALTSELANARDES--KKTANDMIHAENMRLGRDKYKTL 559
+R++ + R+ K+L E + R S ++ + E + YKTL
Sbjct: 597 --FPGQRSSSVPHSPRILPP-KSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTL 653
Query: 560 RQIRQG 565
+ QG
Sbjct: 654 ERRPQG 659
>gi|116063562 FERM domain containing 4A [Homo sapiens]
Length = 1039
Score = 152 bits (383), Expect = 1e-36
Identities = 124/473 (26%), Positives = 210/473 (44%), Gaps = 30/473 (6%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72
D +LE +QP K+L D V L+E +FG+ + D G WL+L+++V D K
Sbjct: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88
Query: 73 ES-PLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQ 131
+S P++ F +FY E +S L + T LFFL K I + I E LASY +Q
Sbjct: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147
Query: 132 SKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEY 191
GDF+ L LP + L++H + E+R+ +++ G R A++ Y
Sbjct: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHP-SLAYCEDRVIEHYKKLNGQTRGQAIVNY 206
Query: 192 LKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFN 251
+ I + L YGV+Y+++K+K+G WLG+ G+ Y+ +D++ P+ F W ++ N+ F
Sbjct: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266
Query: 252 DKKFVIKPIDKKAPD-------------FVFYAPRLRINKRILALCMGNHELYMRRR--K 296
+KKF ++ D + +YA I K I A+ + H+ Y+ R+ K
Sbjct: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALI-KSIWAMAISQHQFYLDRKQSK 325
Query: 297 PDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKI----EREKEELMERLK 352
+ + A + ++ + L N K ++ + +E + K
Sbjct: 326 SKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKK 385
Query: 353 QIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQE-----AEEAKEALLQAS 407
+ K Q+ LEE R+ LE+ +K EAE K E EE +
Sbjct: 386 DMLAALKSRQEALEETLRQ--RLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIG 443
Query: 408 RDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTR 460
K ++++ + E + E A Q + +EA V + L+K R
Sbjct: 444 TAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQR 496
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 146 bits (369), Expect = 4e-35
Identities = 139/536 (25%), Positives = 220/536 (41%), Gaps = 47/536 (8%)
Query: 3 KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
K+ RVT +DA E E ++ + G+ LFD V + + L E +FGL + D WL
Sbjct: 95 KSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDP 154
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
+K++ Q + SP F F KFYP D ++ L +DIT+ LQ++ I+ + C T
Sbjct: 155 SKEIKKQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVT 211
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
LL SYAVQ++ GD++ E H Y++ + P + E EERI H+ +RG
Sbjct: 212 HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRG 263
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
M +A + +L+ A+ L MYGV+ K+ +G ++ LGV A GL IY R+ F
Sbjct: 264 MTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFA 320
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNH---ELYMRR 294
W +I IS+ F IK + F F P R KR+ +C+ +H L
Sbjct: 321 WPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPE 380
Query: 295 RKPDTIEVQQMK--------AQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEE 346
P V K AQ R+ E KR + + E +
Sbjct: 381 PPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPA 440
Query: 347 LMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQA 406
+ K ++ E +R+ E E+ R ++ ++L E++ K+ L
Sbjct: 441 SVSENHDAGPDGDKRDEDGESGGQRS-EAEEGEVRTPTKIKELKPEQETTPRHKQEFLD- 498
Query: 407 SRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTA 466
K ++ L A + L+ K +W++ + R A
Sbjct: 499 -----KPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWER----------ERRLPSSPA 543
Query: 467 MSTPHVAEPAENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHL 522
+P NE+ E E R A D +E++ E + HL
Sbjct: 544 SPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHL 599
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 145 bits (365), Expect = 1e-34
Identities = 120/466 (25%), Positives = 216/466 (46%), Gaps = 33/466 (7%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72
D E ++ + G+ L +V + + L E +FGL D TWL K++ Q +
Sbjct: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQV--R 67
Query: 73 ESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQS 132
P F F KFYP D ++ L +DIT+ LQ+++ I+ + C T LL SY +QS
Sbjct: 68 GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
Query: 133 KYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYL 192
+ GD++ E+H Y++ KL P + E EE++ H+ +R M A LE+L
Sbjct: 127 ELGDYDPELHGVDYVSDFKLAPNQTKE--------LEEKVMELHKSYRSMTPAQADLEFL 178
Query: 193 KIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFND 252
+ A+ L MYGV+ K+ +G ++ LGV + GL +Y+ R+ FPW ++ IS+
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235
Query: 253 KKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308
F IK P +++ + F P R K++ +C+ H + R DTI + A
Sbjct: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
Query: 309 AREEKH------QKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQ 362
+ ++ Q + A+++ E ++ + ++ + T A
Sbjct: 295 GSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPT-SAP 353
Query: 363 QELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQ----EQLA 418
+ Q L+ K+ + K KE +AE KE + + T+ E+
Sbjct: 354 AITQGQVAEGGVLDASAKK--TVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTH 411
Query: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELK 464
+E+ T+ Q + R++ + E + + + + ++ EDL+K++ E+K
Sbjct: 412 IEVTVPTSNGDQTQKKRERLDGENI-YIRHSNLMLEDLDKSQEEIK 456
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 142 bits (357), Expect = 1e-33
Identities = 98/294 (33%), Positives = 149/294 (50%), Gaps = 19/294 (6%)
Query: 3 KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
K+ RVT +DA E E ++ + G+ LFD V + + L E +FGL + D WL
Sbjct: 33 KSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDP 92
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
+K++ Q + SP F F KFYP D ++ L +DIT+ LQ++ I+ + C T
Sbjct: 93 SKEIKKQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVT 149
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
LL SYAVQ++ GD++ E H Y++ + P + E EERI H+ +RG
Sbjct: 150 HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRG 201
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
M +A + +L+ A+ L MYGV+ K+ +G ++ LGV A GL IY R+ F
Sbjct: 202 MTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFA 258
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
W +I IS+ F IK + F F P R KR+ +C+ +H +
Sbjct: 259 WPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 139 bits (350), Expect = 7e-33
Identities = 115/456 (25%), Positives = 208/456 (45%), Gaps = 32/456 (7%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72
D E ++ + G+ L +V + + L E +FGL D TWL K++ Q +
Sbjct: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQV--R 67
Query: 73 ESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQS 132
P F F KFYP D ++ L +DIT+ LQ+++ I+ + C T LL SY +QS
Sbjct: 68 GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
Query: 133 KYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYL 192
+ GD++ E+H Y++ KL P + E EE++ H+ +R M A LE+L
Sbjct: 127 ELGDYDPELHGVDYVSDFKLAPNQTKE--------LEEKVMELHKSYRSMTPAQADLEFL 178
Query: 193 KIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFND 252
+ A+ L MYGV+ K+ +G ++ LGV + GL +Y+ R+ FPW ++ IS+
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235
Query: 253 KKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308
F IK P +++ + F P R K++ +C+ H + R DTI + A
Sbjct: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
Query: 309 AREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQ 368
+ ++ + + ++ + ++ ER + R A +
Sbjct: 295 GSKFRYSGRTQ----AQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPT 350
Query: 369 TRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARI 428
+ A+ Q + +A AK+ + KE + + + + EQ E E +
Sbjct: 351 SAPAITQGQVAEGGVLDAS--AKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKK- 407
Query: 429 SQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELK 464
R++ + E + + + + ++ EDL+K++ E+K
Sbjct: 408 -----KRERLDGENI-YIRHSNLMLEDLDKSQEEIK 437
Score = 29.6 bits (65), Expect = 7.9
Identities = 22/82 (26%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 303 QQMKAQA-REEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
+ +KA+ +E++ +Q E E KKKRE + E I R ++E L + +E+ KK
Sbjct: 381 ETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYI-RHSNLMLEDLDKSQEEIKKH 439
Query: 362 QQELEEQTRRALELEQERKRAQ 383
+ E + +E E + ++
Sbjct: 440 HASISELKKNFMESVPEPRPSE 461
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 139 bits (349), Expect = 9e-33
Identities = 99/378 (26%), Positives = 190/378 (50%), Gaps = 25/378 (6%)
Query: 3 KTISVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
K +S+++ +D E F + GK L D V + L E +FGL++ D K + WL L
Sbjct: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
K + Q +R+ ++ KF KF+P D ++ L +++T+ LF LQVK+ + + C +
Sbjct: 98 LKPIVKQ-IRRPKHVVVKFVVKFFPPDHTQ-LQEELTRYLFALQVKQDLAQGRLTCNDTS 155
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
A LL S+ VQS+ GDF++ + + +LA +K +PQ+ D E++I +H H G
Sbjct: 156 AALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQ---------DALEDKIVEFHHNHIG 205
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
++ + L+IA+ LEMYG+ K+++G+++ L V G+ +++ ++ F
Sbjct: 206 QTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKIN---AFN 262
Query: 242 WSEIRNISFNDKKFVIK--PIDKKA--PDFVFYAPRLRINKRILALCMGNHELYMRRRKP 297
W+++R +SF K+F+IK P A F K +C+ +H + +P
Sbjct: 263 WAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEP 322
Query: 298 DTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQ 357
+ ++ + + ++ +L+ K+ +K + ER K + ++ + Q
Sbjct: 323 KPKPKPVLFSRGSSFRFSGRTQKQVLDYVKE----GGHKKVQFER-KHSKIHSIRSLASQ 377
Query: 358 TKKAQQELEEQTRRALEL 375
+ E+ EQ++++ L
Sbjct: 378 PTELNSEVLEQSQQSTSL 395
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 139 bits (349), Expect = 9e-33
Identities = 95/294 (32%), Positives = 150/294 (51%), Gaps = 19/294 (6%)
Query: 3 KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
KT+ +VT +D E ++ + G+ LFD+V + + L E +FGL +Q++ WL
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
K++ Q + P LF F KFYP D S+ L +DIT+ LQ+++ I + + C T
Sbjct: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
LL SY +Q++ GD++ E H S L+ + P + E EE++ H+ HRG
Sbjct: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHKTHRG 384
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
+ A ++L+ A+ L MYGV+ K+ +G ++ LGV A GL IY+ R+ F
Sbjct: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
W +I IS+ F IK + F F P R KR+ +C+ +H Y
Sbjct: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
Score = 38.5 bits (88), Expect = 0.017
Identities = 28/143 (19%), Positives = 69/143 (48%), Gaps = 8/143 (5%)
Query: 291 YMRRRKPDTIEV------QQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREK 344
+++++K T+ V ++ QA E+ E + E +++ + AE+ +K + K
Sbjct: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
Query: 345 EELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKL--AKERQEAEEAKEA 402
E+ E + ++ K + ++E Q + E+E K +++ +KL ++E +E +
Sbjct: 141 VEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTN 200
Query: 403 LLQASRDQKKTQEQLALEMAELT 425
L+A + +K ++ ++T
Sbjct: 201 ELKAEKASQKVTKKTKTVQCKVT 223
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 139 bits (349), Expect = 9e-33
Identities = 95/294 (32%), Positives = 150/294 (51%), Gaps = 19/294 (6%)
Query: 3 KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
KT+ +VT +D E ++ + G+ LFD+V + + L E +FGL +Q++ WL
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
K++ Q + P LF F KFYP D S+ L +DIT+ LQ+++ I + + C T
Sbjct: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
LL SY +Q++ GD++ E H S L+ + P + E EE++ H+ HRG
Sbjct: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHKTHRG 384
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
+ A ++L+ A+ L MYGV+ K+ +G ++ LGV A GL IY+ R+ F
Sbjct: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
W +I IS+ F IK + F F P R KR+ +C+ +H Y
Sbjct: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
Score = 38.5 bits (88), Expect = 0.017
Identities = 28/143 (19%), Positives = 69/143 (48%), Gaps = 8/143 (5%)
Query: 291 YMRRRKPDTIEV------QQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREK 344
+++++K T+ V ++ QA E+ E + E +++ + AE+ +K + K
Sbjct: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
Query: 345 EELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKL--AKERQEAEEAKEA 402
E+ E + ++ K + ++E Q + E+E K +++ +KL ++E +E +
Sbjct: 141 VEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTN 200
Query: 403 LLQASRDQKKTQEQLALEMAELT 425
L+A + +K ++ ++T
Sbjct: 201 ELKAEKASQKVTKKTKTVQCKVT 223
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 139 bits (349), Expect = 9e-33
Identities = 95/294 (32%), Positives = 150/294 (51%), Gaps = 19/294 (6%)
Query: 3 KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
KT+ +VT +D E ++ + G+ LFD+V + + L E +FGL +Q++ WL
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
K++ Q + P LF F KFYP D S+ L +DIT+ LQ+++ I + + C T
Sbjct: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
LL SY +Q++ GD++ E H S L+ + P + E EE++ H+ HRG
Sbjct: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHKTHRG 384
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
+ A ++L+ A+ L MYGV+ K+ +G ++ LGV A GL IY+ R+ F
Sbjct: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
W +I IS+ F IK + F F P R KR+ +C+ +H Y
Sbjct: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
Score = 38.5 bits (88), Expect = 0.017
Identities = 28/143 (19%), Positives = 69/143 (48%), Gaps = 8/143 (5%)
Query: 291 YMRRRKPDTIEV------QQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREK 344
+++++K T+ V ++ QA E+ E + E +++ + AE+ +K + K
Sbjct: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
Query: 345 EELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKL--AKERQEAEEAKEA 402
E+ E + ++ K + ++E Q + E+E K +++ +KL ++E +E +
Sbjct: 141 VEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTN 200
Query: 403 LLQASRDQKKTQEQLALEMAELT 425
L+A + +K ++ ++T
Sbjct: 201 ELKAEKASQKVTKKTKTVQCKVT 223
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 138 bits (347), Expect = 2e-32
Identities = 110/418 (26%), Positives = 188/418 (44%), Gaps = 44/418 (10%)
Query: 2 PKTISVRVTTMD-AELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
PK++ +V +D +E ++ + G+ LFD+V + + L E +FGL Y+D + WL
Sbjct: 107 PKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLD 166
Query: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
K++ Q + F F KFYP D ++ L +DIT+ LQ+++ I++ + C
Sbjct: 167 PAKEIKKQV--RSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQLRDDIVSGRLPCSFV 223
Query: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
T LL SY VQS+ GD++ + S Y++ + P E E+++ H+ HR
Sbjct: 224 TLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL--------EDKVIELHKSHR 275
Query: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
GM +A + +L+ A+ L MYGV+ K+ +G E+ LGV A GL IY R+ F
Sbjct: 276 GMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRIN---RF 332
Query: 241 PWSEIRNISFNDKKFVIK----PIDKKAPDFVFYAPRLRINKRILALCMGNHELY----- 291
W ++ IS+ F IK ++ F P R KR+ +C+ +H +
Sbjct: 333 AWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP 392
Query: 292 -----------MRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREM-AEKEKEK 339
+ R + Q +A A ++ ER+ + R + E +
Sbjct: 393 EAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQ 452
Query: 340 IEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAE 397
K L KKA++E +E E++++R E ++ R E +
Sbjct: 453 YATTKGISQTNLITTVTPEKKAEEERDE--------EEDKRRKGEEVTPISAIRHEGK 502
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 137 bits (346), Expect = 2e-32
Identities = 83/242 (34%), Positives = 134/242 (55%), Gaps = 14/242 (5%)
Query: 18 FAIQPNTTGKQLFDQVVKTIGLREVWFFGLQY-QDTKGFSTWLKLNKKVTAQDVRKESPL 76
F + + G+ L D V K + L E +FGLQ D+ WL NK + Q +++ SP
Sbjct: 43 FKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQ-LKRGSPY 101
Query: 77 LFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGD 136
FR KF+ D ++ L ++ T+ +FLQ+K+ IL + CP TA LLAS+AVQS+ GD
Sbjct: 102 SLNFRVKFFVSDPNK-LQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGD 160
Query: 137 FNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQ 196
+++ + SGYL+ +P + +E+ I H++H G+ +A YL A+
Sbjct: 161 YDQSENLSGYLSDYSFIPNQ--------PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTAR 212
Query: 197 DLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFV 256
LE+YGV + +++ +E+ +GV + G+ IY+ R+ FPW +I ISF K+F
Sbjct: 213 TLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT---FPWLKIVKISFKCKQFF 269
Query: 257 IK 258
I+
Sbjct: 270 IQ 271
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 135 bits (341), Expect = 8e-32
Identities = 86/283 (30%), Positives = 142/283 (50%), Gaps = 18/283 (6%)
Query: 18 FAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFST-WLKLNKKVTAQDVRKESPL 76
F + TG+ L D V +G+ E +FGLQ+ D S WL+ +K + Q ++ P
Sbjct: 43 FKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQ-LKGGFPC 101
Query: 77 LFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGD 136
FR +F+ D + L Q+ T+ L+FLQ+K I + CP +AV+LASYAVQS +GD
Sbjct: 102 TLHFRVRFFIPDPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
Query: 137 FNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQ 196
+N +H GYL+ +P + + + +++ HE+H G+ + +A Y+ IA+
Sbjct: 161 YNSSIHHPGYLSDSHFIPDQ--------NEDFLTKVESLHEQHSGLKQSEAESCYINIAR 212
Query: 197 DLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFV 256
L+ YGV S ++ +L +G+ + G+ +Y + +PW I ISF KKF
Sbjct: 213 TLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR---KYICTSFYPWVNILKISFKRKKFF 269
Query: 257 IKPIDKKAPD----FVFYAPRLRINKRILALCMGNHELYMRRR 295
I K+A F R K + C+ +H + ++
Sbjct: 270 IHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 135 bits (341), Expect = 8e-32
Identities = 86/283 (30%), Positives = 142/283 (50%), Gaps = 18/283 (6%)
Query: 18 FAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFST-WLKLNKKVTAQDVRKESPL 76
F + TG+ L D V +G+ E +FGLQ+ D S WL+ +K + Q ++ P
Sbjct: 43 FKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQ-LKGGFPC 101
Query: 77 LFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGD 136
FR +F+ D + L Q+ T+ L+FLQ+K I + CP +AV+LASYAVQS +GD
Sbjct: 102 TLHFRVRFFIPDPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
Query: 137 FNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQ 196
+N +H GYL+ +P + + + +++ HE+H G+ + +A Y+ IA+
Sbjct: 161 YNSSIHHPGYLSDSHFIPDQ--------NEDFLTKVESLHEQHSGLKQSEAESCYINIAR 212
Query: 197 DLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFV 256
L+ YGV S ++ +L +G+ + G+ +Y + +PW I ISF KKF
Sbjct: 213 TLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR---KYICTSFYPWVNILKISFKRKKFF 269
Query: 257 IKPIDKKAPD----FVFYAPRLRINKRILALCMGNHELYMRRR 295
I K+A F R K + C+ +H + ++
Sbjct: 270 IHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 135 bits (340), Expect = 1e-31
Identities = 79/257 (30%), Positives = 150/257 (58%), Gaps = 16/257 (6%)
Query: 3 KTISVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
K + +RV +D +E F I+P G+ L QV K + L E +FG+++Q+T+ + WL+
Sbjct: 42 KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
Query: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
K + Q +R+ ++ + KF+P D + L ++ T+ LF LQ+K +L + + C T
Sbjct: 102 MKPIIRQ-IRRPKNVVLRLAVKFFPPDPGQ-LQEEYTRYLFALQLKRDLLEERLTCADTT 159
Query: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
A LL S+ +QS+ GD+++ + + +L ++ LP +QH L E+I +H++H G
Sbjct: 160 AALLTSHLLQSEIGDYDETLDRE-HLKVNEYLPG---QQHCL------EKILEFHQKHVG 209
Query: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
++ + L+IA+ LEMYG+ + +++G+++ L V +G+ +++ ++ F
Sbjct: 210 QTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINT---FN 266
Query: 242 WSEIRNISFNDKKFVIK 258
WS++R +SF K+F+IK
Sbjct: 267 WSKVRKLSFKRKRFLIK 283
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 129 bits (324), Expect = 7e-30
Identities = 81/277 (29%), Positives = 140/277 (50%), Gaps = 15/277 (5%)
Query: 20 IQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQD--VRKESPLL 77
I+ +T G + D V + L E+ +FGL+Y D + WL K + + P
Sbjct: 32 IKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKELINTGPPYT 91
Query: 78 FKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDF 137
F KFY ED + L ++IT+ FFLQVK+ +L + CP TA L +YA+QS+ GD+
Sbjct: 92 LYFGIKFYAEDPCK-LKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDY 150
Query: 138 NKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQD 197
+ H +GY++ + +P + K++ EE I+ H+ G + +A L YL+ A+
Sbjct: 151 DPYKHTAGYVSEYRFVPDQ--------KEELEEAIERIHKTLMGQIPSEAELNYLRTAKS 202
Query: 198 LEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVI 257
LEMYGV+ + + SE +LG+ +G+ +Y+ ++ + W I + F + +F +
Sbjct: 203 LEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGK---YFWPRITKVHFKETQFEL 259
Query: 258 KPIDKKAPD-FVFYAPRLRINKRILALCMGNHELYMR 293
+ + K + F+ R + + L C H + R
Sbjct: 260 RVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFR 296
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 127 bits (320), Expect = 2e-29
Identities = 98/295 (33%), Positives = 150/295 (50%), Gaps = 21/295 (7%)
Query: 16 LEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQ-YQDTKGFSTWLKLNKKVTAQDVRKES 74
LE T K +FD VV IGL E F L +D + F L A + KE
Sbjct: 584 LELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEE 643
Query: 75 P----------LLFKFRAKFYPEDVSEELIQD-ITQRLFFLQVKEGILNDDIYCPPETAV 123
P LF FR KF+ +DVS LIQ +T ++LQ+++ IL + ++C ET++
Sbjct: 644 PKKKTKATVNFTLF-FRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDETSL 700
Query: 124 LLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGML 183
LLAS A+Q++YGD+ EVH Y + LP RV+E KL+ +E + H + G
Sbjct: 701 LLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVME--KLDLSYIKEELPKLHNTYVGAS 758
Query: 184 REDAVLEYLKIAQDLEMYGVNYFSIKNKKGSE--LWLGVDALGLNIYE-QNDRLTPKIGF 240
++ LE+LK+ Q L YGV++ + +K S+ + LGV + G+ ++E N T + F
Sbjct: 759 EKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRF 818
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295
PW E + ISF+ KK ++ F +I + +L LC H+ ++ R
Sbjct: 819 PWRETKKISFSKKKITLQN-TSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMR 872
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,606,017
Number of Sequences: 37866
Number of extensions: 911000
Number of successful extensions: 42360
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1352
Number of HSP's successfully gapped in prelim test: 1223
Number of HSP's that attempted gapping in prelim test: 7258
Number of HSP's gapped (non-prelim): 13174
length of query: 577
length of database: 18,247,518
effective HSP length: 108
effective length of query: 469
effective length of database: 14,157,990
effective search space: 6640097310
effective search space used: 6640097310
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.