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Search of human proteins with 4505001
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505001 LIM domain kinase 1 [Homo sapiens]
(647 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505001 LIM domain kinase 1 [Homo sapiens] 1362 0.0
gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens] 672 0.0
gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens] 654 0.0
gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens] 633 0.0
gi|110349799 testis-specific protein kinase 2 [Homo sapiens] 228 1e-59
gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 226 7e-59
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 139 6e-33
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 130 5e-30
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 129 8e-30
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 126 7e-29
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 126 7e-29
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 125 1e-28
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 125 1e-28
gi|4503787 fyn-related kinase [Homo sapiens] 125 1e-28
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 125 2e-28
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 125 2e-28
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 124 2e-28
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 124 3e-28
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 124 3e-28
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 124 3e-28
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 121 2e-27
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 121 2e-27
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 121 2e-27
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 120 4e-27
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 120 4e-27
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 119 7e-27
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 119 9e-27
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 119 9e-27
gi|32483399 p21-activated kinase 2 [Homo sapiens] 119 9e-27
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 119 9e-27
>gi|4505001 LIM domain kinase 1 [Homo sapiens]
Length = 647
Score = 1362 bits (3526), Expect = 0.0
Identities = 647/647 (100%), Positives = 647/647 (100%)
Query: 1 MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS 60
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
Sbjct: 1 MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS 60
Query: 61 HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD 120
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
Sbjct: 61 HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD 120
Query: 121 GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV 180
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
Sbjct: 121 GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV 180
Query: 181 SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID 240
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
Sbjct: 181 SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID 240
Query: 241 LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID 300
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
Sbjct: 241 LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID 300
Query: 301 RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE 360
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
Sbjct: 301 RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE 360
Query: 361 TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT 420
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
Sbjct: 361 TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT 420
Query: 421 LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG 480
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
Sbjct: 421 LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG 480
Query: 481 LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC 540
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
Sbjct: 481 LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC 540
Query: 541 EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL 600
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
Sbjct: 541 EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL 600
Query: 601 EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD 647
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
Sbjct: 601 EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD 647
>gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
Length = 638
Score = 672 bits (1733), Expect = 0.0
Identities = 342/626 (54%), Positives = 443/626 (70%), Gaps = 27/626 (4%)
Query: 19 GSELPVCASCGQRIYDGQ-YLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYW 77
G ++ C CG I Q + + +N WH CFRC +C SL++ YYEKDG+L+C KDYW
Sbjct: 6 GEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYW 65
Query: 78 ARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHC 137
++GE CHGCS +T G MVAGE KYHPECF C++C I DGD Y LV+H+ LYCG C
Sbjct: 66 GKFGEFCHGCSLLMT-GPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKC 124
Query: 138 YYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSH 197
+ + V+ P+ E++ +S LP++VTL+S+PA++ G+RG SVS++ C + ++
Sbjct: 125 HNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVES-----AC-SNYAT 178
Query: 198 TVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHD 257
TV+V+ V+ +SP+ +N+IH GDRILEINGTP+R + ++E++ I +TS+ LQL +EHD
Sbjct: 179 TVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHD 238
Query: 258 PHDT------LGHGLGPETSPLSSP----AYTPSGEAGSSARQKPVLRSCSIDRSPGAGS 307
P L L P P + R++ + RS SI +SPG S
Sbjct: 239 PVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSS 298
Query: 308 LGSPASQRKDLGRSESLRVVCR-PHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMV 366
P +D+ RSESLR +IFRP DLIHGEVLGKG FGQAIKVTH+ TG+VMV
Sbjct: 299 PKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMV 358
Query: 367 MKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIK 426
MKELIR DEETQ+TFL EVKVMR L+HPNVLKFIGVLYKDK+LN +TEYI+GGTL+ ++
Sbjct: 359 MKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLR 418
Query: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMV 486
SMD +PW Q+V FAK IASGMAYLHSM IIHRDLNSHNCL++ +K VVVADFGL+RL+V
Sbjct: 419 SMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIV 477
Query: 487 DEKTQPE------GLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC 540
+E+ + R+L+K DRKKRYTVVGNPYWMAPEM+NG+SYDE VD+FSFGIVLC
Sbjct: 478 EERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLC 537
Query: 541 EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL 600
EIIG+V ADPD LPRT+DFGLNV+ F +++ P +CPP+FFP+ CC L+PE RP+F KL
Sbjct: 538 EIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 597
Query: 601 EHWLETLRMHLAG-HLPLGPQLEQLD 625
E E L ++L +PL +LE+LD
Sbjct: 598 EDSFEALSLYLGELGIPLPAELEELD 623
>gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]
Length = 617
Score = 654 bits (1687), Expect = 0.0
Identities = 336/609 (55%), Positives = 432/609 (70%), Gaps = 26/609 (4%)
Query: 35 GQYLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKG 94
G YL D FRC +C SL++ YYEKDG+L+C KDYW ++GE CHGCS +T G
Sbjct: 2 GSYLSVPAYFTSRDLFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMT-G 60
Query: 95 LVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDS 154
MVAGE KYHPECF C++C I DGD Y LV+H+ LYCG C+ + V+ P+ E++ +S
Sbjct: 61 PFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTES 120
Query: 155 PGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVK 214
LP++VTL+S+PA++ G+RG SVS++ C + ++ TV+V+ V+ +SP+ +
Sbjct: 121 VQEQLPYSVTLISMPATTEGRRGFSVSVES-----AC-SNYATTVQVKEVNRMHISPNNR 174
Query: 215 NSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDT------LGHGLGP 268
N+IH GDRILEINGTP+R + ++E++ I +TS+ LQL +EHDP L L P
Sbjct: 175 NAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAP 234
Query: 269 ETSPLSSP----AYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESL 324
P + R++ + RS SI +SPG S P +D+ RSESL
Sbjct: 235 HMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESL 294
Query: 325 RVVCR-PHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLK 383
R +IFRP DLIHGEVLGKG FGQAIKVTH+ TG+VMVMKELIR DEETQ+TFL
Sbjct: 295 RCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLT 354
Query: 384 EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKD 443
EVKVMR L+HPNVLKFIGVLYKDK+LN +TEYI+GGTL+ ++SMD +PW Q+V FAK
Sbjct: 355 EVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKG 413
Query: 444 IASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPE------GLRS 497
IASGMAYLHSM IIHRDLNSHNCL++ +K VVVADFGL+RL+V+E+ + R+
Sbjct: 414 IASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRT 473
Query: 498 LKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTM 557
L+K DRKKRYTVVGNPYWMAPEM+NG+SYDE VD+FSFGIVLCEIIG+V ADPD LPRT+
Sbjct: 474 LRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTL 533
Query: 558 DFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAG-HLP 616
DFGLNV+ F +++ P +CPP+FFP+ CC L+PE RP+F KLE E L ++L +P
Sbjct: 534 DFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIP 593
Query: 617 LGPQLEQLD 625
L +LE+LD
Sbjct: 594 LPAELEELD 602
>gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens]
Length = 686
Score = 633 bits (1632), Expect = 0.0
Identities = 322/577 (55%), Positives = 412/577 (71%), Gaps = 25/577 (4%)
Query: 35 GQYLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKG 94
G YL D FRC +C SL++ YYEKDG+L+C KDYW ++GE CHGCS +T G
Sbjct: 2 GSYLSVPAYFTSRDLFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMT-G 60
Query: 95 LVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDS 154
MVAGE KYHPECF C++C I DGD Y LV+H+ LYCG C+ + V+ P+ E++ +S
Sbjct: 61 PFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTES 120
Query: 155 PGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVK 214
LP++VTL+S+PA++ G+RG SVS++ C + ++ TV+V+ V+ +SP+ +
Sbjct: 121 VQEQLPYSVTLISMPATTEGRRGFSVSVES-----AC-SNYATTVQVKEVNRMHISPNNR 174
Query: 215 NSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDT------LGHGLGP 268
N+IH GDRILEINGTP+R + ++E++ I +TS+ LQL +EHDP L L P
Sbjct: 175 NAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAP 234
Query: 269 ETSPLSSP----AYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESL 324
P + R++ + RS SI +SPG S P +D+ RSESL
Sbjct: 235 HMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESL 294
Query: 325 RVVCR-PHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLK 383
R +IFRP DLIHGEVLGKG FGQAIKVTH+ TG+VMVMKELIR DEETQ+TFL
Sbjct: 295 RCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLT 354
Query: 384 EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKD 443
EVKVMR L+HPNVLKFIGVLYKDK+LN +TEYI+GGTL+ ++SMD +PW Q+V FAK
Sbjct: 355 EVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKG 413
Query: 444 IASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPE------GLRS 497
IASGMAYLHSM IIHRDLNSHNCL++ +K VVVADFGL+RL+V+E+ + R+
Sbjct: 414 IASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRT 473
Query: 498 LKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTM 557
L+K DRKKRYTVVGNPYWMAPEM+NG+SYDE VD+FSFGIVLCEIIG+V ADPD LPRT+
Sbjct: 474 LRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTL 533
Query: 558 DFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKR 594
DFGLNV+ F +++ P +CPP+FFP+ CC L+PE R
Sbjct: 534 DFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESR 570
>gi|110349799 testis-specific protein kinase 2 [Homo sapiens]
Length = 571
Score = 228 bits (582), Expect = 1e-59
Identities = 120/272 (44%), Positives = 166/272 (61%), Gaps = 20/272 (7%)
Query: 343 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 402
E +G G F + KV HR +G+VM +K + + LKEV++M L HPN+L+F+GV
Sbjct: 62 EKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMGV 119
Query: 403 LYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLN 462
+L+ +TEYI G L ++ S + PW+ RV A DIA G++YLH I HRDL
Sbjct: 120 CVHQGQLHALTEYINSGNLEQLLDS-NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT 178
Query: 463 SHNCLVRENKN---VVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 519
S NCL++ ++N VVADFGLA + D E L VVG+P+WMAPE
Sbjct: 179 SKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKL------------AVVGSPFWMAPE 226
Query: 520 MINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSF 579
++ Y+EK DVFS+GI+LCEII R+ ADPDYLPRT +FGL+ F ++ +CPP F
Sbjct: 227 VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGDCPPDF 284
Query: 580 FPITVRCCDLDPEKRPSFVKLEHWLETLRMHL 611
+T CC++DP+ RPSFV++ LE + L
Sbjct: 285 LQLTFNCCNMDPKLRPSFVEIGKTLEEILSRL 316
>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
Length = 626
Score = 226 bits (575), Expect = 7e-59
Identities = 133/319 (41%), Positives = 178/319 (55%), Gaps = 22/319 (6%)
Query: 303 PGAGSLGSPASQRKDLGRSESLRVV-CRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRET 361
PG G G + GR S R + + R D E +G G F + KV HR++
Sbjct: 24 PGPGGTGGGPGR----GRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQS 79
Query: 362 GEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTL 421
G+VMV+K + + T L+EV++M L HPN+L+F+GV +L+ +TEY+ GGTL
Sbjct: 80 GQVMVLK-MNKLPSNRGNT-LREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTL 137
Query: 422 RGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKN---VVVAD 478
++ S + W R+ A DIA G+ YLHS + HRDL S NCLVR VV D
Sbjct: 138 EQLLSSPEP-LSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGD 196
Query: 479 FGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIV 538
FGLA E + ++ RK+ VVG+PYWMAPE++ G YDEK DVF+FGIV
Sbjct: 197 FGLA----------EKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIV 246
Query: 539 LCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFV 598
LCE+I RV ADPDYLPRT DFGL+V F +CP F + + CC+L+P R F
Sbjct: 247 LCELIARVPADPDYLPRTEDFGLDVPAF-RTLVGDDCPLPFLLLAIHCCNLEPSTRAPFT 305
Query: 599 KLEHWLETLRMHLAGHLPL 617
++ LE + L PL
Sbjct: 306 EITQHLEWILEQLPEPAPL 324
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 139 bits (351), Expect = 6e-33
Identities = 89/279 (31%), Positives = 133/279 (47%), Gaps = 14/279 (5%)
Query: 333 IFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLE 392
I D+I GE+LGKG FG+ K T ++ V V +E + FL+E K+++ +
Sbjct: 557 ILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYD 616
Query: 393 HPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLH 452
HPN++K IGV + + + I E + GG ++ + Q V F+ D A+GM YL
Sbjct: 617 HPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLE 676
Query: 453 SMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGN 512
S N IHRDL + NCLV EN + ++DFG++R GL+ +
Sbjct: 677 SKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIK----------- 725
Query: 513 PYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCP 572
W APE +N Y + DV+SFGI+L E + RG+ P
Sbjct: 726 --WTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGY-RMSAP 782
Query: 573 PNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHL 611
+CP I ++C D PE RP F +L+ L ++ L
Sbjct: 783 QHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKL 821
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 130 bits (326), Expect = 5e-30
Identities = 87/301 (28%), Positives = 140/301 (46%), Gaps = 29/301 (9%)
Query: 324 LRVVCRPHRIFRPSDLIH-------------GEVLGKGCFGQA----IKVTHRETGEVMV 366
LR PH P+ +H +V+G G FG+ +K+ ++ V +
Sbjct: 593 LRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAI 652
Query: 367 MKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIK 426
+ + E+ +R FL E +M +HPN+++ GV+ K K + +TEY++ G+L ++
Sbjct: 653 KTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR 712
Query: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMV 486
D+Q+ Q V + IASGM YL M +HRDL + N L+ N V+DFGL+R++
Sbjct: 713 KHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLE 772
Query: 487 DEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRV 546
D+ R K P R W +PE I R + DV+S+GIVL E++
Sbjct: 773 DDPEAAYTTRGGKIPIR-----------WTSPEAIAYRKFTSASDVWSYGIVLWEVMS-Y 820
Query: 547 NADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLET 606
P + D V P +CP + + + + C D RP F ++ L+
Sbjct: 821 GERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDK 880
Query: 607 L 607
L
Sbjct: 881 L 881
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 129 bits (324), Expect = 8e-30
Identities = 86/272 (31%), Positives = 137/272 (50%), Gaps = 20/272 (7%)
Query: 343 EVLGKGCFGQAIKVTHRETG--EVMVMKELIR--FDEETQRTFLKEVKVMRCLEHPNVLK 398
EV+G G FG+ K + G E+ V + ++ + E+ +R FL E +M +HPN+++
Sbjct: 623 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIR 682
Query: 399 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 458
GV+ K + + ITE+++ G L ++ D Q+ Q V + IA+GM YL MN +H
Sbjct: 683 LEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVH 742
Query: 459 RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSL--KKPDRKKRYTVVGNPYWM 516
RDL + N LV N V+DFGL+R + D+ + P SL K P R W
Sbjct: 743 RDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVR-----------WT 791
Query: 517 APEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPP-NC 575
APE I R + DV+S+GIV+ E++ + Y + +N R PP +C
Sbjct: 792 APEAIAYRKFTSASDVWSYGIVMWEVMS--FGERPYWDMSNQDVINAIEQDYRLPPPMDC 849
Query: 576 PPSFFPITVRCCDLDPEKRPSFVKLEHWLETL 607
P + + + C D RP F ++ + L+ +
Sbjct: 850 PAALHQLMLDCWQKDRNSRPRFAEIVNTLDKM 881
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 126 bits (316), Expect = 7e-29
Identities = 84/301 (27%), Positives = 137/301 (45%), Gaps = 29/301 (9%)
Query: 324 LRVVCRPHRIFRPSDLIHG-------------EVLGKGCFGQA----IKVTHRETGEVMV 366
+R PH P+ +H V+G G FG+ +K+ + V +
Sbjct: 625 VRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAI 684
Query: 367 MKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIK 426
+ + E+ +R FL E +M +HPN++ GV+ K K + +TEY++ G+L +K
Sbjct: 685 KTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLK 744
Query: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMV 486
D Q+ Q V + I++GM YL M +HRDL + N L+ N V+DFGL+R++
Sbjct: 745 KNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLE 804
Query: 487 DEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRV 546
D+ R K P R W APE I R + DV+S+GIV+ E++
Sbjct: 805 DDPEAAYTTRGGKIPIR-----------WTAPEAIAFRKFTSASDVWSYGIVMWEVVS-Y 852
Query: 547 NADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLET 606
P + D V P +CP + + + + C + RP F ++ + L+
Sbjct: 853 GERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDK 912
Query: 607 L 607
L
Sbjct: 913 L 913
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 126 bits (316), Expect = 7e-29
Identities = 84/301 (27%), Positives = 137/301 (45%), Gaps = 29/301 (9%)
Query: 324 LRVVCRPHRIFRPSDLIHG-------------EVLGKGCFGQA----IKVTHRETGEVMV 366
+R PH P+ +H V+G G FG+ +K+ + V +
Sbjct: 647 VRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAI 706
Query: 367 MKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIK 426
+ + E+ +R FL E +M +HPN++ GV+ K K + +TEY++ G+L +K
Sbjct: 707 KTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLK 766
Query: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMV 486
D Q+ Q V + I++GM YL M +HRDL + N L+ N V+DFGL+R++
Sbjct: 767 KNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLE 826
Query: 487 DEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRV 546
D+ R K P R W APE I R + DV+S+GIV+ E++
Sbjct: 827 DDPEAAYTTRGGKIPIR-----------WTAPEAIAFRKFTSASDVWSYGIVMWEVVS-Y 874
Query: 547 NADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLET 606
P + D V P +CP + + + + C + RP F ++ + L+
Sbjct: 875 GERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDK 934
Query: 607 L 607
L
Sbjct: 935 L 935
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 125 bits (314), Expect = 1e-28
Identities = 95/275 (34%), Positives = 137/275 (49%), Gaps = 25/275 (9%)
Query: 336 PSDLIHGEV-LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHP 394
P + + EV LG+GCFG+ T T V + + ++ + FL+E +VM+ L H
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAI--KTLKPGTMSPEAFLQEAQVMKKLRHE 323
Query: 395 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQY-PWSQRVSFAKDIASGMAYLHS 453
+++ V+ ++ + +TEY+ G+L +K +Y Q V A IASGMAY+
Sbjct: 324 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382
Query: 454 MNIIHRDLNSHNCLVRENKNVVVADFGLARLMVD-EKTQPEGLRSLKKPDRKKRYTVVGN 512
MN +HRDL + N LV EN VADFGLARL+ D E T +G + K
Sbjct: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK------------ 430
Query: 513 PYWMAPEMINGRSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRTMDFGLNVRGFLDRY 570
W APE + K DV+SFGI+L E+ GRV +D V
Sbjct: 431 --WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD---QVERGYRMP 485
Query: 571 CPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLE 605
CPP CP S + +C +PE+RP+F L+ +LE
Sbjct: 486 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 125 bits (314), Expect = 1e-28
Identities = 95/275 (34%), Positives = 137/275 (49%), Gaps = 25/275 (9%)
Query: 336 PSDLIHGEV-LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHP 394
P + + EV LG+GCFG+ T T V + + ++ + FL+E +VM+ L H
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAI--KTLKPGTMSPEAFLQEAQVMKKLRHE 323
Query: 395 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQY-PWSQRVSFAKDIASGMAYLHS 453
+++ V+ ++ + +TEY+ G+L +K +Y Q V A IASGMAY+
Sbjct: 324 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382
Query: 454 MNIIHRDLNSHNCLVRENKNVVVADFGLARLMVD-EKTQPEGLRSLKKPDRKKRYTVVGN 512
MN +HRDL + N LV EN VADFGLARL+ D E T +G + K
Sbjct: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK------------ 430
Query: 513 PYWMAPEMINGRSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRTMDFGLNVRGFLDRY 570
W APE + K DV+SFGI+L E+ GRV +D V
Sbjct: 431 --WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD---QVERGYRMP 485
Query: 571 CPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLE 605
CPP CP S + +C +PE+RP+F L+ +LE
Sbjct: 486 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 125 bits (314), Expect = 1e-28
Identities = 92/272 (33%), Positives = 137/272 (50%), Gaps = 28/272 (10%)
Query: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404
LG G FG+ + T V V + ++ FL+E ++M+ L HP +++ V
Sbjct: 240 LGSGQFGEVWEGLWNNTTPVAV--KTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCT 297
Query: 405 KDKRLNFITEYIKGGTLRGIIKS-MDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNS 463
+ + ITE ++ G+L+ +++ S+ +Q+V A +ASGMAYL S N IHRDL +
Sbjct: 298 LEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAA 357
Query: 464 HNCLVRENKNVVVADFGLARLM-VDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN 522
N LV E+ VADFGLAR+ VD + E +K P + W APE I
Sbjct: 358 RNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK-----------WTAPEAIR 406
Query: 523 GRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYC----PPNCPPS 578
+ K DV+SFGI+L EII +P + G V L + P NCP
Sbjct: 407 SNKFSIKSDVWSFGILLYEII-----TYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
Query: 579 FFPITVRCCDLDPEKRPSFV----KLEHWLET 606
F+ I + C + +P++RP+F KLE + ET
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYFET 493
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 125 bits (313), Expect = 2e-28
Identities = 85/272 (31%), Positives = 135/272 (49%), Gaps = 20/272 (7%)
Query: 343 EVLGKGCFGQAIKVTHRETG--EVMVMKELIR--FDEETQRTFLKEVKVMRCLEHPNVLK 398
+V+G G FG+ + G E+ V + ++ + E+ +R FL E +M +HPNV+
Sbjct: 625 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 684
Query: 399 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 458
GV+ K + ITE+++ G+L ++ D Q+ Q V + IA+GM YL MN +H
Sbjct: 685 LEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVH 744
Query: 459 RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSL--KKPDRKKRYTVVGNPYWM 516
RDL + N LV N V+DFGL+R + D+ + P +L K P R W
Sbjct: 745 RDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIR-----------WT 793
Query: 517 APEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPP-NC 575
APE I R + DV+S+GIV+ E++ + Y T +N R PP +C
Sbjct: 794 APEAIQYRKFTSASDVWSYGIVMWEVMS--YGERPYWDMTNQDVINAIEQDYRLPPPMDC 851
Query: 576 PPSFFPITVRCCDLDPEKRPSFVKLEHWLETL 607
P + + + C D RP F ++ + L+ +
Sbjct: 852 PSALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 883
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
sapiens]
Length = 987
Score = 125 bits (313), Expect = 2e-28
Identities = 85/272 (31%), Positives = 135/272 (49%), Gaps = 20/272 (7%)
Query: 343 EVLGKGCFGQAIKVTHRETG--EVMVMKELIR--FDEETQRTFLKEVKVMRCLEHPNVLK 398
+V+G G FG+ + G E+ V + ++ + E+ +R FL E +M +HPNV+
Sbjct: 626 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 685
Query: 399 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 458
GV+ K + ITE+++ G+L ++ D Q+ Q V + IA+GM YL MN +H
Sbjct: 686 LEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVH 745
Query: 459 RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSL--KKPDRKKRYTVVGNPYWM 516
RDL + N LV N V+DFGL+R + D+ + P +L K P R W
Sbjct: 746 RDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIR-----------WT 794
Query: 517 APEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPP-NC 575
APE I R + DV+S+GIV+ E++ + Y T +N R PP +C
Sbjct: 795 APEAIQYRKFTSASDVWSYGIVMWEVMS--YGERPYWDMTNQDVINAIEQDYRLPPPMDC 852
Query: 576 PPSFFPITVRCCDLDPEKRPSFVKLEHWLETL 607
P + + + C D RP F ++ + L+ +
Sbjct: 853 PSALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 884
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 124 bits (312), Expect = 2e-28
Identities = 85/272 (31%), Positives = 136/272 (50%), Gaps = 20/272 (7%)
Query: 343 EVLGKGCFGQAIKVTHRETG--EVMVMKELIR--FDEETQRTFLKEVKVMRCLEHPNVLK 398
EV+G G FG+ + ++ G EV V + ++ + E +R FL E +M +HPN+++
Sbjct: 637 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIR 696
Query: 399 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 458
GV+ K + + +TE+++ L ++ D Q+ Q V + IA+GM YL MN +H
Sbjct: 697 LEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVH 756
Query: 459 RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSL--KKPDRKKRYTVVGNPYWM 516
RDL + N LV N V+DFGL+R + D+ + P SL K P R W
Sbjct: 757 RDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIR-----------WT 805
Query: 517 APEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPP-NC 575
APE I R + DV+S+GIV+ E++ + Y + +N R PP +C
Sbjct: 806 APEAIAYRKFTSASDVWSYGIVMWEVMS--YGERPYWDMSNQDVINAVEQDYRLPPPMDC 863
Query: 576 PPSFFPITVRCCDLDPEKRPSFVKLEHWLETL 607
P + + + C D RP F ++ + L+ L
Sbjct: 864 PTALHQLMLDCWVRDRNLRPKFSQIVNTLDKL 895
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 124 bits (311), Expect = 3e-28
Identities = 90/271 (33%), Positives = 135/271 (49%), Gaps = 36/271 (13%)
Query: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404
LG GCFG T G V + ++ + + FL+E +VM+ L H +++ V+
Sbjct: 269 LGTGCFGDVWLGTWN--GSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV- 325
Query: 405 KDKRLNFITEYIKGGTLRGIIKSMDSQ-YPWSQRVSFAKDIASGMAYLHSMNIIHRDLNS 463
++ + +TE++ G+L +K+ + Q Q V A +A GMAY+ MN IHRDL +
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385
Query: 464 HNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMING 523
N LV E +ADFGLARL+ D++ P + K P + W APE
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNP--CQGSKFPIK-----------WTAPEAALF 432
Query: 524 RSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRTMDFGLNVRGFLDRY-------CPPN 574
+ K DV+SFGI+L E+I GR+ G+N R L++ CPP
Sbjct: 433 GRFTIKSDVWSFGILLTELITKGRIPYP----------GMNKREVLEQVEQGYHMPCPPG 482
Query: 575 CPPSFFPITVRCCDLDPEKRPSFVKLEHWLE 605
CP S + + LDPE+RP+F L+ +LE
Sbjct: 483 CPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 124 bits (311), Expect = 3e-28
Identities = 90/271 (33%), Positives = 135/271 (49%), Gaps = 36/271 (13%)
Query: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404
LG GCFG T G V + ++ + + FL+E +VM+ L H +++ V+
Sbjct: 269 LGTGCFGDVWLGTWN--GSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV- 325
Query: 405 KDKRLNFITEYIKGGTLRGIIKSMDSQ-YPWSQRVSFAKDIASGMAYLHSMNIIHRDLNS 463
++ + +TE++ G+L +K+ + Q Q V A +A GMAY+ MN IHRDL +
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385
Query: 464 HNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMING 523
N LV E +ADFGLARL+ D++ P + K P + W APE
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNP--CQGSKFPIK-----------WTAPEAALF 432
Query: 524 RSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRTMDFGLNVRGFLDRY-------CPPN 574
+ K DV+SFGI+L E+I GR+ G+N R L++ CPP
Sbjct: 433 GRFTIKSDVWSFGILLTELITKGRIPYP----------GMNKREVLEQVEQGYHMPCPPG 482
Query: 575 CPPSFFPITVRCCDLDPEKRPSFVKLEHWLE 605
CP S + + LDPE+RP+F L+ +LE
Sbjct: 483 CPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 124 bits (311), Expect = 3e-28
Identities = 90/271 (33%), Positives = 135/271 (49%), Gaps = 36/271 (13%)
Query: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404
LG GCFG T G V + ++ + + FL+E +VM+ L H +++ V+
Sbjct: 269 LGTGCFGDVWLGTWN--GSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV- 325
Query: 405 KDKRLNFITEYIKGGTLRGIIKSMDSQ-YPWSQRVSFAKDIASGMAYLHSMNIIHRDLNS 463
++ + +TE++ G+L +K+ + Q Q V A +A GMAY+ MN IHRDL +
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385
Query: 464 HNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMING 523
N LV E +ADFGLARL+ D++ P + K P + W APE
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNP--CQGSKFPIK-----------WTAPEAALF 432
Query: 524 RSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRTMDFGLNVRGFLDRY-------CPPN 574
+ K DV+SFGI+L E+I GR+ G+N R L++ CPP
Sbjct: 433 GRFTIKSDVWSFGILLTELITKGRIPYP----------GMNKREVLEQVEQGYHMPCPPG 482
Query: 575 CPPSFFPITVRCCDLDPEKRPSFVKLEHWLE 605
CP S + + LDPE+RP+F L+ +LE
Sbjct: 483 CPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 121 bits (304), Expect = 2e-27
Identities = 90/269 (33%), Positives = 141/269 (52%), Gaps = 32/269 (11%)
Query: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404
LG G FG+ T+ + +V V + ++ + FL E VM+ L+H ++K V+
Sbjct: 268 LGAGQFGEVWMATYNKHTKVAV--KTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVT 325
Query: 405 KDKRLNFITEYIKGGTLRGIIKSMD-SQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNS 463
K+ + ITE++ G+L +KS + S+ P + + F+ IA GMA++ N IHRDL +
Sbjct: 326 KEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRA 384
Query: 464 HNCLVRENKNVVVADFGLARLMVD-EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN 522
N LV + +ADFGLAR++ D E T EG + K W APE IN
Sbjct: 385 ANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIK--------------WTAPEAIN 430
Query: 523 GRSYDEKVDVFSFGIVLCEII--GRV----NADPDYLPRTMDFGLNVRGFLDRYCPPNCP 576
S+ K DV+SFGI+L EI+ GR+ ++P+ + R ++ G + P NCP
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVI-RALERGYRMPR------PENCP 483
Query: 577 PSFFPITVRCCDLDPEKRPSFVKLEHWLE 605
+ I +RC PE+RP+F ++ L+
Sbjct: 484 EELYNIMMRCWKNRPEERPTFEYIQSVLD 512
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 121 bits (303), Expect = 2e-27
Identities = 104/394 (26%), Positives = 172/394 (43%), Gaps = 50/394 (12%)
Query: 243 IQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAY-TPSGEAGSSARQKPVL------- 294
+Q LLQ LEH LG G P L + T S E + P L
Sbjct: 319 LQAQQELLQTKLEH-----LGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHI 373
Query: 295 ------RSCSIDRSPGAGSLGSPA------SQRKDLGRSESL---RVVCRPHRIFRPSDL 339
+ ++ R G G P S ++ L + + R V + + DL
Sbjct: 374 SGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDL 433
Query: 340 IHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQRTFLKEVKVMRCLEHPNVLK 398
+ GE +G+G FG+ R ++ +K + + FL+E ++++ HPN+++
Sbjct: 434 VLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVR 493
Query: 399 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 458
IGV + + + + E ++GG +++ ++ + D A+GM YL S IH
Sbjct: 494 LIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIH 553
Query: 459 RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 518
RDL + NCLV E + ++DFG++R D G L++ K W AP
Sbjct: 554 RDLAARNCLVTEKNVLKISDFGMSREEADGVYAASG--GLRQVPVK----------WTAP 601
Query: 519 EMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDR----YCPPN 574
E +N Y + DV+SFGI+L E + A P P + R F+++ CP
Sbjct: 602 EALNYGRYSSESDVWSFGILLWETFS-LGASP--YPNLSN--QQTREFVEKGGRLPCPEL 656
Query: 575 CPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLR 608
CP + F + +C +P +RPSF + L+++R
Sbjct: 657 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 690
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 121 bits (303), Expect = 2e-27
Identities = 104/394 (26%), Positives = 172/394 (43%), Gaps = 50/394 (12%)
Query: 243 IQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAY-TPSGEAGSSARQKPVL------- 294
+Q LLQ LEH LG G P L + T S E + P L
Sbjct: 377 LQAQQELLQTKLEH-----LGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHI 431
Query: 295 ------RSCSIDRSPGAGSLGSPA------SQRKDLGRSESL---RVVCRPHRIFRPSDL 339
+ ++ R G G P S ++ L + + R V + + DL
Sbjct: 432 SGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDL 491
Query: 340 IHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQRTFLKEVKVMRCLEHPNVLK 398
+ GE +G+G FG+ R ++ +K + + FL+E ++++ HPN+++
Sbjct: 492 VLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVR 551
Query: 399 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 458
IGV + + + + E ++GG +++ ++ + D A+GM YL S IH
Sbjct: 552 LIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIH 611
Query: 459 RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 518
RDL + NCLV E + ++DFG++R D G L++ K W AP
Sbjct: 612 RDLAARNCLVTEKNVLKISDFGMSREEADGVYAASG--GLRQVPVK----------WTAP 659
Query: 519 EMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDR----YCPPN 574
E +N Y + DV+SFGI+L E + A P P + R F+++ CP
Sbjct: 660 EALNYGRYSSESDVWSFGILLWETFS-LGASP--YPNLSN--QQTREFVEKGGRLPCPEL 714
Query: 575 CPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLR 608
CP + F + +C +P +RPSF + L+++R
Sbjct: 715 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 748
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 120 bits (301), Expect = 4e-27
Identities = 81/289 (28%), Positives = 139/289 (48%), Gaps = 22/289 (7%)
Query: 325 RVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQRTFLK 383
R V + + DL+ GE +G+G FG+ R ++ +K + + FL+
Sbjct: 489 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 548
Query: 384 EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKD 443
E ++++ HPN+++ IGV + + + + E ++GG +++ ++ + D
Sbjct: 549 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 608
Query: 444 IASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDR 503
A+GM YL S IHRDL + NCLV E + ++DFG++R D G L++
Sbjct: 609 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASG--GLRQVPV 666
Query: 504 KKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNV 563
K W APE +N Y + DV+SFGI+L E + A P P +
Sbjct: 667 K----------WTAPEALNYGRYSSESDVWSFGILLWETFS-LGASP--YPNLSN--QQT 711
Query: 564 RGFLDR----YCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLR 608
R F+++ CP CP + F + +C +P +RPSF + L+++R
Sbjct: 712 REFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 760
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 120 bits (301), Expect = 4e-27
Identities = 81/289 (28%), Positives = 139/289 (48%), Gaps = 22/289 (7%)
Query: 325 RVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQRTFLK 383
R V + + DL+ GE +G+G FG+ R ++ +K + + FL+
Sbjct: 547 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 606
Query: 384 EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKD 443
E ++++ HPN+++ IGV + + + + E ++GG +++ ++ + D
Sbjct: 607 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 666
Query: 444 IASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDR 503
A+GM YL S IHRDL + NCLV E + ++DFG++R D G L++
Sbjct: 667 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASG--GLRQVPV 724
Query: 504 KKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNV 563
K W APE +N Y + DV+SFGI+L E + A P P +
Sbjct: 725 K----------WTAPEALNYGRYSSESDVWSFGILLWETFS-LGASP--YPNLSN--QQT 769
Query: 564 RGFLDR----YCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLR 608
R F+++ CP CP + F + +C +P +RPSF + L+++R
Sbjct: 770 REFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 818
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 119 bits (299), Expect = 7e-27
Identities = 83/280 (29%), Positives = 134/280 (47%), Gaps = 23/280 (8%)
Query: 336 PSDLIHGEVLGKGCFGQAIK---VTHRETGEVMVMKELIR--FDEETQRTFLKEVKVMRC 390
PS + +V+G G FG+ K T EV V + ++ + E+ + FL E +M
Sbjct: 610 PSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQ 669
Query: 391 LEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAY 450
H N+++ GV+ K K + ITEY++ G L ++ D ++ Q V + IA+GM Y
Sbjct: 670 FSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKY 729
Query: 451 LHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV 510
L +MN +HRDL + N LV N V+DFGL+R++ D D + YT
Sbjct: 730 LANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLED--------------DPEATYTTS 775
Query: 511 GNPY---WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFL 567
G W APE I+ R + DV+SFGIV+ E++ P + + +
Sbjct: 776 GGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVM-TYGERPYWELSNHEVMKAINDGF 834
Query: 568 DRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETL 607
P +CP + + + ++C + +RP F + L+ L
Sbjct: 835 RLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKL 874
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 119 bits (298), Expect = 9e-27
Identities = 99/360 (27%), Positives = 161/360 (44%), Gaps = 51/360 (14%)
Query: 288 ARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGK 347
A+ PV S S R P S+ + S ++ +++ P F +L+ G+ LG+
Sbjct: 680 AQAFPVSYSSSGARRPSLDSMENQVSV-------DAFKILEDPKWEFPRKNLVLGKTLGE 732
Query: 348 GCFGQAIKVT----HRETGEVMVMKELIRFDEETQ--RTFLKEVKVMRCLEHPNVLKFIG 401
G FG+ +K T G V ++++ + R L E V++ + HP+V+K G
Sbjct: 733 GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG 792
Query: 402 VLYKDKRLNFITEYIKGGTLRGIIKSMDSQYP-----------------------WSQRV 438
+D L I EY K G+LRG ++ P +
Sbjct: 793 ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLI 852
Query: 439 SFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSL 498
SFA I+ GM YL M ++HRDL + N LV E + + ++DFGL+R + +E + + RS
Sbjct: 853 SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVK--RSQ 910
Query: 499 KKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMD 558
+ K WMA E + Y + DV+SFG++L EI+ +P
Sbjct: 911 GRIPVK----------WMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960
Query: 559 FGLNVRGF-LDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPL 617
F L G ++R P NC + + ++C +P+KRP F + LE + + +L L
Sbjct: 961 FNLLKTGHRMER--PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDL 1018
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 119 bits (298), Expect = 9e-27
Identities = 99/360 (27%), Positives = 161/360 (44%), Gaps = 51/360 (14%)
Query: 288 ARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGK 347
A+ PV S S R P S+ + S ++ +++ P F +L+ G+ LG+
Sbjct: 680 AQAFPVSYSSSGARRPSLDSMENQVSV-------DAFKILEDPKWEFPRKNLVLGKTLGE 732
Query: 348 GCFGQAIKVT----HRETGEVMVMKELIRFDEETQ--RTFLKEVKVMRCLEHPNVLKFIG 401
G FG+ +K T G V ++++ + R L E V++ + HP+V+K G
Sbjct: 733 GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG 792
Query: 402 VLYKDKRLNFITEYIKGGTLRGIIKSMDSQYP-----------------------WSQRV 438
+D L I EY K G+LRG ++ P +
Sbjct: 793 ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLI 852
Query: 439 SFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSL 498
SFA I+ GM YL M ++HRDL + N LV E + + ++DFGL+R + +E + + RS
Sbjct: 853 SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVK--RSQ 910
Query: 499 KKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMD 558
+ K WMA E + Y + DV+SFG++L EI+ +P
Sbjct: 911 GRIPVK----------WMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960
Query: 559 FGLNVRGF-LDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPL 617
F L G ++R P NC + + ++C +P+KRP F + LE + + +L L
Sbjct: 961 FNLLKTGHRMER--PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDL 1018
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 119 bits (298), Expect = 9e-27
Identities = 79/281 (28%), Positives = 134/281 (47%), Gaps = 27/281 (9%)
Query: 343 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 402
E +G+G G T G+ + +K++ + + + E+ VM+ L++PN++ F+
Sbjct: 253 EKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDS 312
Query: 403 LYKDKRLNFITEYIKGGTLRGIIKS--MDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRD 460
L + EY+ GG+L ++ MD +Q + ++ + +LH+ +IHRD
Sbjct: 313 YLVGDELFVVMEYLAGGSLTDVVTETCMDE----AQIAAVCRECLQALEFLHANQVIHRD 368
Query: 461 LNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEM 520
+ S N L+ +V + DFG + P++ KR T+VG PYWMAPE+
Sbjct: 369 IKSDNVLLGMEGSVKLTDFGFCAQIT--------------PEQSKRSTMVGTPYWMAPEV 414
Query: 521 INGRSYDEKVDVFSFGIVLCEIIGRVNADPDYL---PRTMDFGLNVRGFLDRYCPPNCPP 577
+ ++Y KVD++S GI+ E+ V +P YL P + + G + P P
Sbjct: 415 VTRKAYGPKVDIWSLGIMAIEM---VEGEPPYLNENPLRALYLIATNGTPELQNPEKLSP 471
Query: 578 SFFPITVRCCDLDPEKRPSFVK-LEHWLETLRMHLAGHLPL 617
F RC ++D EKR S + L+H L L+ PL
Sbjct: 472 IFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPL 512
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 119 bits (298), Expect = 9e-27
Identities = 82/271 (30%), Positives = 128/271 (47%), Gaps = 18/271 (6%)
Query: 343 EVLGKGCFGQAIKVTHRETG--EVMVMKELIR--FDEETQRTFLKEVKVMRCLEHPNVLK 398
EV+G G FG+ + + G E V + ++ + E +R FL E +M EHPN+++
Sbjct: 619 EVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIR 678
Query: 399 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 458
GV+ + +TE+++ G L ++ D Q+ Q V + IASGM YL M+ +H
Sbjct: 679 LEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVH 738
Query: 459 RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSL--KKPDRKKRYTVVGNPYWM 516
RDL + N LV N V+DFGL+R + + + P SL K P R W
Sbjct: 739 RDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIR-----------WT 787
Query: 517 APEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCP 576
APE I R + D +S+GIV+ E++ P + D + PP+CP
Sbjct: 788 APEAIAFRKFTSASDAWSYGIVMWEVMS-FGERPYWDMSNQDVINAIEQDYRLPPPPDCP 846
Query: 577 PSFFPITVRCCDLDPEKRPSFVKLEHWLETL 607
S + + C D RP F ++ L+ +
Sbjct: 847 TSLHQLMLDCWQKDRNARPRFPQVVSALDKM 877
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.445
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,218,665
Number of Sequences: 37866
Number of extensions: 1529505
Number of successful extensions: 7582
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 821
Number of HSP's successfully gapped in prelim test: 178
Number of HSP's that attempted gapping in prelim test: 4411
Number of HSP's gapped (non-prelim): 1452
length of query: 647
length of database: 18,247,518
effective HSP length: 109
effective length of query: 538
effective length of database: 14,120,124
effective search space: 7596626712
effective search space used: 7596626712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.