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Search of human proteins with 4504503
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo
sapiens]
(387 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 790 0.0
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi... 241 8e-64
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 169 4e-42
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 169 4e-42
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 169 4e-42
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 169 4e-42
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 168 7e-42
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 168 7e-42
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 168 7e-42
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 163 2e-40
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 161 8e-40
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 161 1e-39
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 149 3e-36
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 83 4e-16
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 72 6e-13
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 67 2e-11
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 57 2e-08
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 56 6e-08
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 56 6e-08
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 54 2e-07
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 54 2e-07
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens] 53 4e-07
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 52 9e-07
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 52 9e-07
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 52 9e-07
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 50 3e-06
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens] 49 6e-06
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo... 49 6e-06
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 49 8e-06
gi|4502599 carbonyl reductase 1 [Homo sapiens] 48 1e-05
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 790 bits (2041), Expect = 0.0
Identities = 387/387 (100%), Positives = 387/387 (100%)
Query: 1 MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL 60
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
Sbjct: 1 MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL 60
Query: 61 FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG 120
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
Sbjct: 61 FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG 120
Query: 121 AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL 180
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
Sbjct: 121 AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL 180
Query: 181 LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT 240
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
Sbjct: 181 LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT 240
Query: 241 MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI 300
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
Sbjct: 241 MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI 300
Query: 301 LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD 360
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
Sbjct: 301 LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD 360
Query: 361 YFAKRHFGQDKPMPRALRMPNYKKKAT 387
YFAKRHFGQDKPMPRALRMPNYKKKAT
Sbjct: 361 YFAKRHFGQDKPMPRALRMPNYKKKAT 387
>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
Length = 405
Score = 241 bits (615), Expect = 8e-64
Identities = 147/373 (39%), Positives = 201/373 (53%), Gaps = 3/373 (0%)
Query: 6 SDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSC 65
S AW+ +A +L + + L + + LA L +C +L P L + + +
Sbjct: 8 SGGAWLLVAARALL--QLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAG 65
Query: 66 FLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELR 125
++ + L+ + LPV +AVL+TG D G G K LD +GFTV A VL N PGA ELR
Sbjct: 66 WIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELR 125
Query: 126 RTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDY 185
CSPRL +LQMD+TKP I A GLW ++NNAG D EL + +
Sbjct: 126 TCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATF 185
Query: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245
+ CM VNFFG +E+TK LPLLR S+GR+V V S G P L +YG+SKAAV +
Sbjct: 186 RSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDT 245
Query: 246 MRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRN 305
EL WG+KV+ IQPG F T +WEK ++ +L +LP E+ + YG+DYI
Sbjct: 246 FSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHG 305
Query: 306 FLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKR 365
L LA D +PV+ I A+LA P Y PG+G L + +YLP G+ F +
Sbjct: 306 QFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQA 365
Query: 366 HFGQDKPMPRALR 378
F +PRAL+
Sbjct: 366 FF-ISHCLPRALQ 377
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 169 bits (428), Expect = 4e-42
Identities = 107/312 (34%), Positives = 169/312 (54%), Gaps = 15/312 (4%)
Query: 55 FWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL 114
FW L L + C ++T ++ + K + +TG D G G+ + D+ GF V A L
Sbjct: 3 FWVLGLL-ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACL 61
Query: 115 NENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFP 174
E+G A L+ S RL + +D+T P +K V + ++GLW +INNAGV G
Sbjct: 62 TESGSTA--LKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVL 119
Query: 175 TDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLA---- 230
+ L + DY++ + VN FG + VT LPL++K++GR++NVSS+GG RLA
Sbjct: 120 APTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGG-----RLAIVGG 174
Query: 231 SYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAE 290
Y SK AV F+ +R ++ +G+ V+ I+PG F TN+A EK + I + L +
Sbjct: 175 GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEK-KLAIWEQLSPD 233
Query: 291 VQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYL-WIC 349
+++ YG+ YI + L S + D SPV+ + HA+ + P +Y GK A + WI
Sbjct: 234 IKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP 293
Query: 350 LAHYLPIGIYDY 361
L+H +P + D+
Sbjct: 294 LSH-MPAALQDF 304
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 169 bits (428), Expect = 4e-42
Identities = 107/312 (34%), Positives = 169/312 (54%), Gaps = 15/312 (4%)
Query: 55 FWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL 114
FW L L + C ++T ++ + K + +TG D G G+ + D+ GF V A L
Sbjct: 3 FWVLGLL-ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACL 61
Query: 115 NENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFP 174
E+G A L+ S RL + +D+T P +K V + ++GLW +INNAGV G
Sbjct: 62 TESGSTA--LKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVL 119
Query: 175 TDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLA---- 230
+ L + DY++ + VN FG + VT LPL++K++GR++NVSS+GG RLA
Sbjct: 120 APTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGG-----RLAIVGG 174
Query: 231 SYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAE 290
Y SK AV F+ +R ++ +G+ V+ I+PG F TN+A EK + I + L +
Sbjct: 175 GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEK-KLAIWEQLSPD 233
Query: 291 VQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYL-WIC 349
+++ YG+ YI + L S + D SPV+ + HA+ + P +Y GK A + WI
Sbjct: 234 IKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP 293
Query: 350 LAHYLPIGIYDY 361
L+H +P + D+
Sbjct: 294 LSH-MPAALQDF 304
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 169 bits (428), Expect = 4e-42
Identities = 107/312 (34%), Positives = 169/312 (54%), Gaps = 15/312 (4%)
Query: 55 FWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL 114
FW L L + C ++T ++ + K + +TG D G G+ + D+ GF V A L
Sbjct: 3 FWVLGLL-ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACL 61
Query: 115 NENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFP 174
E+G A L+ S RL + +D+T P +K V + ++GLW +INNAGV G
Sbjct: 62 TESGSTA--LKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVL 119
Query: 175 TDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLA---- 230
+ L + DY++ + VN FG + VT LPL++K++GR++NVSS+GG RLA
Sbjct: 120 APTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGG-----RLAIVGG 174
Query: 231 SYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAE 290
Y SK AV F+ +R ++ +G+ V+ I+PG F TN+A EK + I + L +
Sbjct: 175 GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEK-KLAIWEQLSPD 233
Query: 291 VQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYL-WIC 349
+++ YG+ YI + L S + D SPV+ + HA+ + P +Y GK A + WI
Sbjct: 234 IKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP 293
Query: 350 LAHYLPIGIYDY 361
L+H +P + D+
Sbjct: 294 LSH-MPAALQDF 304
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 169 bits (428), Expect = 4e-42
Identities = 107/312 (34%), Positives = 169/312 (54%), Gaps = 15/312 (4%)
Query: 55 FWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL 114
FW L L + C ++T ++ + K + +TG D G G+ + D+ GF V A L
Sbjct: 3 FWVLGLL-ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACL 61
Query: 115 NENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFP 174
E+G A L+ S RL + +D+T P +K V + ++GLW +INNAGV G
Sbjct: 62 TESGSTA--LKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVL 119
Query: 175 TDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLA---- 230
+ L + DY++ + VN FG + VT LPL++K++GR++NVSS+GG RLA
Sbjct: 120 APTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGG-----RLAIVGG 174
Query: 231 SYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAE 290
Y SK AV F+ +R ++ +G+ V+ I+PG F TN+A EK + I + L +
Sbjct: 175 GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEK-KLAIWEQLSPD 233
Query: 291 VQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYL-WIC 349
+++ YG+ YI + L S + D SPV+ + HA+ + P +Y GK A + WI
Sbjct: 234 IKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP 293
Query: 350 LAHYLPIGIYDY 361
L+H +P + D+
Sbjct: 294 LSH-MPAALQDF 304
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 168 bits (426), Expect = 7e-42
Identities = 107/287 (37%), Positives = 160/287 (55%), Gaps = 15/287 (5%)
Query: 70 TYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL--NENGPGAEELRRT 127
TY S E PV KAVLVTG D G G +L K+L GF VFAG L ++ G +EL
Sbjct: 45 TYASAAE--PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSL 102
Query: 128 CSPRLSVLQMDITKPVQIKDAYSKVAAMLQD--RGLWAVINNAGVLGFPTDGELLLMTDY 185
S RL +Q+++ +++ V + L+D +G+W ++NNAG+ F + E + Y
Sbjct: 103 NSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFG-EVEFTSLETY 161
Query: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245
KQ VN +GTV +TK+FLPL+R++KGR+VN+SSM G + Y +K V FS
Sbjct: 162 KQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC 221
Query: 246 MRLELSKWGIKVASIQPGGFLTNIAGTS----DKWEKLEKDILDHLPAEVQEDYGQDYIL 301
+R E+ G+KV+ ++PG F IA TS + + + K + + LP V++DYG+ Y
Sbjct: 222 LRYEMYPLGVKVSVVEPGNF---IAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFD 278
Query: 302 AQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWI 348
+ + S S D SPV+ + HA+ A +P+ Y P Y W+
Sbjct: 279 EKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP-MDYYWWL 324
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 168 bits (426), Expect = 7e-42
Identities = 107/287 (37%), Positives = 160/287 (55%), Gaps = 15/287 (5%)
Query: 70 TYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL--NENGPGAEELRRT 127
TY S E PV KAVLVTG D G G +L K+L GF VFAG L ++ G +EL
Sbjct: 45 TYASAAE--PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSL 102
Query: 128 CSPRLSVLQMDITKPVQIKDAYSKVAAMLQD--RGLWAVINNAGVLGFPTDGELLLMTDY 185
S RL +Q+++ +++ V + L+D +G+W ++NNAG+ F + E + Y
Sbjct: 103 NSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFG-EVEFTSLETY 161
Query: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245
KQ VN +GTV +TK+FLPL+R++KGR+VN+SSM G + Y +K V FS
Sbjct: 162 KQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC 221
Query: 246 MRLELSKWGIKVASIQPGGFLTNIAGTS----DKWEKLEKDILDHLPAEVQEDYGQDYIL 301
+R E+ G+KV+ ++PG F IA TS + + + K + + LP V++DYG+ Y
Sbjct: 222 LRYEMYPLGVKVSVVEPGNF---IAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFD 278
Query: 302 AQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWI 348
+ + S S D SPV+ + HA+ A +P+ Y P Y W+
Sbjct: 279 EKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP-MDYYWWL 324
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 168 bits (426), Expect = 7e-42
Identities = 107/287 (37%), Positives = 160/287 (55%), Gaps = 15/287 (5%)
Query: 70 TYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL--NENGPGAEELRRT 127
TY S E PV KAVLVTG D G G +L K+L GF VFAG L ++ G +EL
Sbjct: 45 TYASAAE--PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSL 102
Query: 128 CSPRLSVLQMDITKPVQIKDAYSKVAAMLQD--RGLWAVINNAGVLGFPTDGELLLMTDY 185
S RL +Q+++ +++ V + L+D +G+W ++NNAG+ F + E + Y
Sbjct: 103 NSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFG-EVEFTSLETY 161
Query: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245
KQ VN +GTV +TK+FLPL+R++KGR+VN+SSM G + Y +K V FS
Sbjct: 162 KQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC 221
Query: 246 MRLELSKWGIKVASIQPGGFLTNIAGTS----DKWEKLEKDILDHLPAEVQEDYGQDYIL 301
+R E+ G+KV+ ++PG F IA TS + + + K + + LP V++DYG+ Y
Sbjct: 222 LRYEMYPLGVKVSVVEPGNF---IAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFD 278
Query: 302 AQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWI 348
+ + S S D SPV+ + HA+ A +P+ Y P Y W+
Sbjct: 279 EKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP-MDYYWWL 324
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 163 bits (413), Expect = 2e-40
Identities = 104/303 (34%), Positives = 159/303 (52%), Gaps = 4/303 (1%)
Query: 58 LILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNEN 117
L +F +L++ Y Q L + K V +TG D G G L + LD G V A L E
Sbjct: 5 LAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK 64
Query: 118 GPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDG 177
G AE+LR S RL + +D+TK + A V ++D+GLW ++NNAG+
Sbjct: 65 G--AEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPN 122
Query: 178 ELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKA 237
ELL D+ + VN G ++VT + LPL+R+++GR+VNVSS+ G + Y SK
Sbjct: 123 ELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFG-GGYCISKY 181
Query: 238 AVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQ 297
V FS +R ELS +G+KVA I+PG F T + + +++ K +I D EV+E YG+
Sbjct: 182 GVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVT-SKERFLKSFLEIWDRSSPEVKEAYGE 240
Query: 298 DYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIG 357
++ + + ++D S V ++HA++A P Y+ G A L Y+P
Sbjct: 241 KFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTF 300
Query: 358 IYD 360
+ D
Sbjct: 301 LVD 303
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 161 bits (408), Expect = 8e-40
Identities = 108/318 (33%), Positives = 162/318 (50%), Gaps = 14/318 (4%)
Query: 50 LILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTV 109
L L+ F GL +L++ Y Q + + K V +TG D G G+ L + LD G V
Sbjct: 3 LYLAAFVGLY------YLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRV 56
Query: 110 FAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAG 169
A L E G AE+LR S RL + +D+TK I A V + DRGLW ++NNAG
Sbjct: 57 LAACLTEKG--AEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAG 114
Query: 170 VLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERL 229
+L T E L D + VN G ++VT + LPL+R+++GR+VNVSS+ G +
Sbjct: 115 ILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAF-FV 173
Query: 230 ASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPA 289
Y SK V FS ++R E+ +G+K++ ++PG F T + + E++ K P
Sbjct: 174 GGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERM-KQSWKEAPK 232
Query: 290 EVQEDYGQDYILAQRNFLL--LINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLW 347
++E YGQ Y A N + L+N S + + V ++HA+ + P Y+ G A +
Sbjct: 233 HIKETYGQQYFDALYNIMKEGLLN--CSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFF 290
Query: 348 ICLAHYLPIGIYDYFAKR 365
YLP + DY R
Sbjct: 291 FIPLSYLPTSLADYILTR 308
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 161 bits (407), Expect = 1e-39
Identities = 104/301 (34%), Positives = 160/301 (53%), Gaps = 7/301 (2%)
Query: 68 MYTYLSGQELLP-VDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRR 126
MY + L+ + +K V +TG D G G+ L K L + G V A E G +++L+R
Sbjct: 10 MYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEG--SQKLQR 67
Query: 127 TCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTD-GELLLMTDY 185
S RL +D+TK IK A V + ++GLWA++NNAGV G P+ E L D+
Sbjct: 68 DTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGV-GLPSGPNEWLTKDDF 126
Query: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245
+ + VN G +EVT LP++++++GR+VN+SS GG + Y SK V FS
Sbjct: 127 VKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDS 185
Query: 246 MRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRN 305
+R EL +G+KV I+PG + T I G + ++ K + + LP E ++ YG+DY +
Sbjct: 186 IRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRK-LWERLPQETRDSYGEDYFRIYTD 244
Query: 306 FLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKR 365
L I +A V+ ++HAI+++SP Y PG A L LP + D+ R
Sbjct: 245 KLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFILSR 304
Query: 366 H 366
+
Sbjct: 305 Y 305
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 149 bits (377), Expect = 3e-36
Identities = 100/314 (31%), Positives = 160/314 (50%), Gaps = 21/314 (6%)
Query: 56 WGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLN 115
W +L + + L ++ LP V +TG D G G L LD+ GF V A L
Sbjct: 2 WLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLT 61
Query: 116 ENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPT 175
+G AE+L+R S RL +DIT P ++ A V +++ GL+ ++NNAGV G
Sbjct: 62 PSG--AEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIG 119
Query: 176 DGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGS- 234
L D+++ + VN G + VT LPLL++++GR++N++S+ G RLA+ G
Sbjct: 120 PTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLG-----RLAANGGG 174
Query: 235 ---SKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEV 291
SK + FS +R +++ +GI+V+ ++PG F T + + EK + LP
Sbjct: 175 YCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNL-ESLEKTLQACWARLPPAT 233
Query: 292 QEDYGQDYI-----LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYL 346
Q YG ++ + QR ++N + D + V R ++HA+ A+ P Y+PG A L
Sbjct: 234 QAHYGGAFLTKYLKMQQR----IMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKL 289
Query: 347 WICLAHYLPIGIYD 360
A YLP + D
Sbjct: 290 LWLPASYLPASLVD 303
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 83.2 bits (204), Expect = 4e-16
Identities = 60/197 (30%), Positives = 93/197 (47%), Gaps = 11/197 (5%)
Query: 83 KAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKP 142
K V+VTGG G+G + + G V +E+G A E P + D+T+
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL---PGAVFILCDVTQE 66
Query: 143 VQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKT 202
+K S+ L V+NNAG P E ++Q + +N GT +TK
Sbjct: 67 DDVKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKL 124
Query: 203 FLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQP 262
LP LRKS+G ++N+SS+ G + Y ++K AVT + + L+ S +G++V I P
Sbjct: 125 ALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISP 184
Query: 263 GGFLTNIAGTSDKWEKL 279
G T + WE+L
Sbjct: 185 GNIWTPL------WEEL 195
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 72.4 bits (176), Expect = 6e-13
Identities = 85/336 (25%), Positives = 150/336 (44%), Gaps = 51/336 (15%)
Query: 35 WSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGL 94
W ++ L LCA+ LL++ L L + + + V VTG G+
Sbjct: 3 WELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGI 62
Query: 95 GHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDI-TKPVQIKDAYSKVA 153
G L L +LG ++ + E ++R C ++ + DI P+ + D S A
Sbjct: 63 GEELAYQLSKLGVSLVLSARRVHE--LERVKRRCLENGNLKEKDILVLPLDLTDTGSHEA 120
Query: 154 A---MLQDRG-LWAVINNAGVLGFPTDGELLLMTD---YKQCMAVNFFGTVEVTKTFLP- 205
A +LQ+ G + ++NN G+ + L + T Y++ + +N+ GTV +TK LP
Sbjct: 121 ATKAVLQEFGRIDILVNNGGM----SQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPH 176
Query: 206 LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKW-GIKVASIQPGG 264
++ + +G++V V+S+ G + Y +SK A+ F + +R EL+ + GI V++I PG
Sbjct: 177 MIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGP 236
Query: 265 FLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQD-----YILAQRNFLLLINSLASKDFS 319
+NI S L EV + G + + R L++ S+A+
Sbjct: 237 VQSNIVENS-------------LAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMAN---- 279
Query: 320 PVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLP 355
D++ +++ PF T YLW Y+P
Sbjct: 280 ----DLKEVWISEQPFLLVT-----YLW----QYMP 302
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 67.4 bits (163), Expect = 2e-11
Identities = 63/225 (28%), Positives = 107/225 (47%), Gaps = 19/225 (8%)
Query: 85 VLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPV- 143
V++TG GLG K G + + NG EEL R + + ++ KP
Sbjct: 55 VVITGATSGLGKECAKVFYAAGAKLV--LCGRNGGALEELIRELTASHAT-KVQTHKPYL 111
Query: 144 ---QIKDAYSKVAA---MLQDRGLWAV-INNAGVLGFPTDGELLLMTDYKQCMAVNFFGT 196
+ D+ + VAA +LQ G + +NNAG+ T + + D K+ M N+FG
Sbjct: 112 VTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVD-KRVMETNYFGP 170
Query: 197 VEVTKTFLP-LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGI 255
V +TK LP ++++ +G +V +SS+ G + ++Y +SK A F +R E+ ++ I
Sbjct: 171 VALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEI 230
Query: 256 KVASIQPGGFLTNIAGTSDKWEKLEKDILD------HLPAEVQED 294
+V I PG TN++ + + ++D P EV +D
Sbjct: 231 EVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQD 275
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/205 (23%), Positives = 90/205 (43%), Gaps = 15/205 (7%)
Query: 86 LVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQI 145
+VTG G+G + + L + G V +++ + +++ + V I
Sbjct: 54 VVTGSTDGIGKSYAEELAKHGMKVV--LISRSKDKLDQVSSEIKEKFKVETRTIAVDFAS 111
Query: 146 KDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDY----KQCMAVNFFGTVEVTK 201
+D Y K+ L + ++NN G + + L + D K+ + +N ++T+
Sbjct: 112 EDIYDKIKTGLAGLEIGILVNNVG-MSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQ 170
Query: 202 TFLP-LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASI 260
LP ++ +SKG ++N+SS G P+ L Y ++K V FS + E G+ V S+
Sbjct: 171 LVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSV 230
Query: 261 QPGGFLTNIAGTSDKWEKLEKDILD 285
P T +A K+ K LD
Sbjct: 231 LPYFVATKLA-------KIRKPTLD 248
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 55.8 bits (133), Expect = 6e-08
Identities = 54/181 (29%), Positives = 79/181 (43%), Gaps = 15/181 (8%)
Query: 85 VLVTGGDCGLGHALCKYLDELG----FTVFAGVLNENGPGAEELRRTCSPRLSVLQMDIT 140
VL+TG + G+G L + LG T L + G R+ +P++ + D+
Sbjct: 32 VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVG--NCRKLGAPKVFYIAADMA 89
Query: 141 KPVQIKDAYSKVAAMLQDR--GL-WAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTV 197
P +A V D+ GL + V+N+ G G P + M VNF V
Sbjct: 90 SP----EAPESVVQFALDKLGGLDYLVLNHIG--GAPAGTRARSPQATRWLMQVNFVSYV 143
Query: 198 EVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKV 257
++T LP L SKG LV VSS+ G P Y ++K A+ F +R EL + V
Sbjct: 144 QLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203
Query: 258 A 258
A
Sbjct: 204 A 204
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 55.8 bits (133), Expect = 6e-08
Identities = 54/181 (29%), Positives = 79/181 (43%), Gaps = 15/181 (8%)
Query: 85 VLVTGGDCGLGHALCKYLDELG----FTVFAGVLNENGPGAEELRRTCSPRLSVLQMDIT 140
VL+TG + G+G L + LG T L + G R+ +P++ + D+
Sbjct: 32 VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVG--NCRKLGAPKVFYIAADMA 89
Query: 141 KPVQIKDAYSKVAAMLQDR--GL-WAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTV 197
P +A V D+ GL + V+N+ G G P + M VNF V
Sbjct: 90 SP----EAPESVVQFALDKLGGLDYLVLNHIG--GAPAGTRARSPQATRWLMQVNFVSYV 143
Query: 198 EVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKV 257
++T LP L SKG LV VSS+ G P Y ++K A+ F +R EL + V
Sbjct: 144 QLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203
Query: 258 A 258
A
Sbjct: 204 A 204
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 54.3 bits (129), Expect = 2e-07
Identities = 54/197 (27%), Positives = 87/197 (44%), Gaps = 13/197 (6%)
Query: 69 YTYLSGQELLP--VDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGV-----LNENGPGA 121
Y Y + +E P + K V+VTG G+G + +L ++G V L +
Sbjct: 19 YYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHC 78
Query: 122 EELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLL 181
EL + ++ D+T Q K+ L D + I N + F D
Sbjct: 79 LELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGL-DMLILNHITNTSLNLFHDD----- 132
Query: 182 MTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTM 241
+ ++ M VNF V +T LP+L++S G +V VSS+ G +A+Y +SK A+
Sbjct: 133 IHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDG 192
Query: 242 FSSVMRLELSKWGIKVA 258
F S +R E S + V+
Sbjct: 193 FFSSIRKEYSVSRVNVS 209
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 54.3 bits (129), Expect = 2e-07
Identities = 54/197 (27%), Positives = 87/197 (44%), Gaps = 13/197 (6%)
Query: 69 YTYLSGQELLP--VDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGV-----LNENGPGA 121
Y Y + +E P + K V+VTG G+G + +L ++G V L +
Sbjct: 19 YYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHC 78
Query: 122 EELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLL 181
EL + ++ D+T Q K+ L D + I N + F D
Sbjct: 79 LELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGL-DMLILNHITNTSLNLFHDD----- 132
Query: 182 MTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTM 241
+ ++ M VNF V +T LP+L++S G +V VSS+ G +A+Y +SK A+
Sbjct: 133 IHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDG 192
Query: 242 FSSVMRLELSKWGIKVA 258
F S +R E S + V+
Sbjct: 193 FFSSIRKEYSVSRVNVS 209
>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
Length = 310
Score = 53.1 bits (126), Expect = 4e-07
Identities = 59/235 (25%), Positives = 96/235 (40%), Gaps = 12/235 (5%)
Query: 32 GQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGD 91
G + L GL VCL L+ + FS L Y + + L + ++TG
Sbjct: 2 GDVLEQFFILTGLL-VCLACLAK---CVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAG 57
Query: 92 CGLGHALCKYLDELGFTV--FAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAY 149
G+G A L + G V + L + A E+ RT + ++Q D TK D Y
Sbjct: 58 DGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKD----DIY 113
Query: 150 SKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMA-VNFFGTVEVTKTFLPLLR 208
+ L + ++NN G+L L D Q + N V++T+ L +
Sbjct: 114 EHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHME 173
Query: 209 -KSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQP 262
+ KG ++N+SS P + Y +SKA V FS ++ E + + + P
Sbjct: 174 SRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTP 228
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 52.0 bits (123), Expect = 9e-07
Identities = 58/199 (29%), Positives = 88/199 (44%), Gaps = 26/199 (13%)
Query: 86 LVTGGDCGLGHALCKYLDELGFTVFAGVLNE----------NGPGAEELRRTCSPR--LS 133
LVTG G+G A+ L G TV A L+ GPG++E PR +
Sbjct: 15 LVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKE----GPPRGNHA 70
Query: 134 VLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMT---DYKQCMA 190
Q D+++ + +V A R V++ AG+ T E LL D+ + +A
Sbjct: 71 AFQADVSEARAARCLLEQVQACFS-RPPSVVVSCAGI----TQDEFLLHMSEDDWDKVIA 125
Query: 191 VNFFGTVEVTKTFLPLLRKS--KGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRL 248
VN GT VT+ L + +G ++N+SS+ G +Y +SKA V +
Sbjct: 126 VNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAR 185
Query: 249 ELSKWGIKVASIQPGGFLT 267
EL + GI+ S+ PG T
Sbjct: 186 ELGRHGIRCNSVLPGFIAT 204
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 52.0 bits (123), Expect = 9e-07
Identities = 47/194 (24%), Positives = 88/194 (45%), Gaps = 9/194 (4%)
Query: 86 LVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG--AEELRRTCSPRLSVLQMDITKPV 143
+V+G G+G A + L G + NE A+++ T ++ D +
Sbjct: 71 VVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSGR 130
Query: 144 QIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYK--QCMAVNFFGTVEVTK 201
+I Y + L+D+ + ++NN GV +P +++ K + VN +
Sbjct: 131 EI---YLPIREALKDKDVGILVNNVGVF-YPYPQYFTQLSEDKLWDIINVNIAAASLMVH 186
Query: 202 TFLP-LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASI 260
LP ++ + KG +V +SS P +LA++ +SKA + FS ++ E + GI V S+
Sbjct: 187 VVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSL 246
Query: 261 QPGGFLTNIAGTSD 274
P T++ S+
Sbjct: 247 IPFYVATSMTAPSN 260
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 52.0 bits (123), Expect = 9e-07
Identities = 48/196 (24%), Positives = 87/196 (44%), Gaps = 14/196 (7%)
Query: 83 KAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPR-----LSVLQM 137
+ VL++G G+G L L + V G +E + L+V Q+
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQL 65
Query: 138 DITKPVQIKDAYSKVAAMLQDRGLWAVINNAGV-LGFPTDGELLLMTDYKQCMAVNFFGT 196
D+ + S + + ++NNAG+ L P +G L + + NFFG
Sbjct: 66 DVCSDESVAQCLSCIQGEVD-----VLVNNAGMGLVGPLEG--LSLAAMQNVFDTNFFGA 118
Query: 197 VEVTKTFLP-LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGI 255
V + K LP + R+ +G +V +SS+ G + Y +SK A+ F + ++L ++ I
Sbjct: 119 VRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNI 178
Query: 256 KVASIQPGGFLTNIAG 271
++ ++PG +T G
Sbjct: 179 FISLVEPGPVVTEFEG 194
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 50.4 bits (119), Expect = 3e-06
Identities = 64/237 (27%), Positives = 110/237 (46%), Gaps = 34/237 (14%)
Query: 49 LLILSPFWGLILFSVSCFLMYTYLSG--QELLPVDQKAVLVTGGDCGLGHALCKYLDELG 106
LL+L PF +L+ + + SG + + K V+VTG + G+G K L + G
Sbjct: 9 LLLLLPF---LLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRG 65
Query: 107 FTVFAGVLN-ENGP-GAEELRRTC-SPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWA 163
V+ + E G A+E++ T + ++ V ++D++ I+ A++K + +++ L
Sbjct: 66 ARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIR-AFAK-GFLAEEKHLHV 123
Query: 164 VINNAGVLGFP----TDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKS-KGRLVNVS 218
+INNAGV+ P DG ++ + VN G +T L L++S R+VNVS
Sbjct: 124 LINNAGVMMCPYSKTADG-------FEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVS 176
Query: 219 SMG---GGAPMERL---------ASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPG 263
S+ G L +Y SK A +F+ + L G+ S+ PG
Sbjct: 177 SLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPG 233
>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
Length = 292
Score = 49.3 bits (116), Expect = 6e-06
Identities = 53/206 (25%), Positives = 82/206 (39%), Gaps = 16/206 (7%)
Query: 65 CFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELG-FTVFAG-----VLNENG 118
C Y +L +LL K +TGG G+G + + G TV A VL
Sbjct: 13 CLPAYRHLFCPDLLR--DKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAAR 70
Query: 119 PGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGE 178
A R C P L MD+ P + A + L++ G ++ N F
Sbjct: 71 KLAGATGRRCLP----LSMDVRAPPAVMAAVDQA---LKEFGRIDILINCAAGNFLCPAG 123
Query: 179 LLLMTDYKQCMAVNFFGTVEVTKT-FLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKA 237
L +K M ++ GT V++ + R G +VN+++ G GS+KA
Sbjct: 124 ALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKA 183
Query: 238 AVTMFSSVMRLELSKWGIKVASIQPG 263
AV + + +E I+V S+ PG
Sbjct: 184 AVDAMTRHLAVEWGPQNIRVNSLAPG 209
>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
sapiens]
Length = 330
Score = 49.3 bits (116), Expect = 6e-06
Identities = 51/215 (23%), Positives = 92/215 (42%), Gaps = 31/215 (14%)
Query: 79 PVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEEL-----RRTCSPRLS 133
P + +VTGG G+G++ K+L LG V + N A+++ T + ++
Sbjct: 40 PRPDRVAIVTGGTDGIGYSTAKHLARLGMHVI--IAGNNDSKAKQVVSKIKEETLNDKVE 97
Query: 134 VLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNF 193
L D+ I+ K ++ L +INNAGV+ P + +++ +N+
Sbjct: 98 FLYCDLASMTSIRQFVQKF--KMKKIPLHVLINNAGVMMVP---QRKTRDGFEEHFGLNY 152
Query: 194 FGTVEVTKTFLPLLRKS-----KGRLVNVSS------------MGGGAPMERLASYGSSK 236
G +T L L++S R+V VSS + A A+Y SK
Sbjct: 153 LGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSK 212
Query: 237 AAVTMFSSVMRLELSKWGIKVAS--IQPGGFLTNI 269
A+ +F+ ++ L+ G V + + PG T++
Sbjct: 213 LALVLFTYHLQRLLAAEGSHVTANVVDPGVVNTDV 247
>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
Length = 335
Score = 48.9 bits (115), Expect = 8e-06
Identities = 50/211 (23%), Positives = 90/211 (42%), Gaps = 8/211 (3%)
Query: 83 KAVLVTGGDCGLGHALCKYLDELGF--TVFAGVLNENGPGAEELRRTCSPRLSVLQMDIT 140
K +TGG GLG + L LG + + ++ AE++ ++ +Q D+
Sbjct: 60 KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
Query: 141 KPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVT 200
P +++ S++ + + VINNA F + E L +K + GT VT
Sbjct: 120 DPDMVQNTVSELIKVAGHPNI--VINNAAG-NFISPTERLSPNAWKTITDIVLNGTAFVT 176
Query: 201 KTF-LPLLRKSKGR-LVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVA 258
L++ KG ++++++ + S+KA V S + E K+G++
Sbjct: 177 LEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFN 236
Query: 259 SIQPGGFLTNIA-GTSDKWEKLEKDILDHLP 288
IQPG T A D EK+++ +P
Sbjct: 237 VIQPGPIKTKGAFSRLDPTGTFEKEMIGRIP 267
>gi|4502599 carbonyl reductase 1 [Homo sapiens]
Length = 277
Score = 48.1 bits (113), Expect = 1e-05
Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 86 LVTGGDCGLGHALCKYLDEL--GFTVFAGVLNENGPGAEELRRT--CSPRLSVLQMDITK 141
LVTGG+ G+G A+ + L L G V G A + + SPR L +D +
Sbjct: 9 LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQ 68
Query: 142 PVQ-IKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVT 200
++ ++D K + GL ++NNAG+ F + M NFFGT +V
Sbjct: 69 SIRALRDFLRK-----EYGGLDVLVNNAGI-AFKVADPTPFHIQAEVTMKTNFFGTRDVC 122
Query: 201 KTFLPLLRKSKGRLVNVSSM 220
LPL+ K +GR+VNVSS+
Sbjct: 123 TELLPLI-KPQGRVVNVSSI 141
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,348,805
Number of Sequences: 37866
Number of extensions: 675295
Number of successful extensions: 1427
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 1324
Number of HSP's gapped (non-prelim): 72
length of query: 387
length of database: 18,247,518
effective HSP length: 104
effective length of query: 283
effective length of database: 14,309,454
effective search space: 4049575482
effective search space used: 4049575482
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.