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Search of human proteins with 4504215
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
(619 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 1249 0.0
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 340 2e-93
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 294 2e-79
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 294 2e-79
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 294 2e-79
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 294 2e-79
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 293 4e-79
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 275 9e-74
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 173 5e-43
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 170 3e-42
gi|134152694 guanylate cyclase 2F [Homo sapiens] 160 2e-39
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 160 3e-39
gi|222080083 guanylate cyclase 2C [Homo sapiens] 150 3e-36
gi|31083193 adenylate cyclase 1 [Homo sapiens] 115 1e-25
gi|4557257 adenylate cyclase 8 [Homo sapiens] 110 4e-24
gi|50959205 adenylate cyclase 9 [Homo sapiens] 105 9e-23
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 105 2e-22
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 105 2e-22
gi|148536830 adenylate cyclase 3 [Homo sapiens] 103 6e-22
gi|34486092 adenylate cyclase 5 [Homo sapiens] 103 6e-22
gi|4557255 adenylate cyclase 7 [Homo sapiens] 102 1e-21
gi|115387102 adenylate cyclase 2 [Homo sapiens] 100 5e-21
gi|24497587 adenylate cyclase 4 [Homo sapiens] 99 9e-21
gi|194595480 guanylate cyclase 1, soluble, alpha 3 isoform C [Ho... 77 6e-14
gi|170650672 Leber congenital amaurosis 5 [Homo sapiens] 35 0.27
gi|170650670 Leber congenital amaurosis 5 [Homo sapiens] 35 0.27
gi|22749047 coiled-coil domain containing 24 [Homo sapiens] 32 2.3
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 31 3.9
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 31 3.9
gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo... 31 3.9
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 1249 bits (3231), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN 60
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
Sbjct: 1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN 60
Query: 61 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF 120
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
Sbjct: 61 LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF 120
Query: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
Sbjct: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
Query: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL 240
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
Sbjct: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL 240
Query: 241 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE 300
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
Sbjct: 241 PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE 300
Query: 301 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR 360
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
Sbjct: 301 ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR 360
Query: 361 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV 420
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
Sbjct: 361 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV 420
Query: 421 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM 480
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
Sbjct: 421 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM 480
Query: 481 TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY 540
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
Sbjct: 481 TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY 540
Query: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ 600
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
Sbjct: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ 600
Query: 601 VWFLSRKNTGTEETKQDDD 619
VWFLSRKNTGTEETKQDDD
Sbjct: 601 VWFLSRKNTGTEETKQDDD 619
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 340 bits (872), Expect = 2e-93
Identities = 205/543 (37%), Positives = 315/543 (58%), Gaps = 41/543 (7%)
Query: 51 LVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLAT 110
++ + +L L EI + FG+ FF C + +LR +G +++F DAL +H+ T
Sbjct: 154 ILQCTANILGLKFEEIQKRFGEEFFNICFHEN-ERVLRAVGGTLQDFFNGFDALLEHIRT 212
Query: 111 IY---PGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVI 167
+ + +PSF C + +G L+LHY+ + ++G+IK ++I+ +D++V
Sbjct: 213 SFGKQATLESPSFLCKELPEGT-LMLHYFHPHHIVGFAMLGMIKAAGKKIY--RLDVEVE 269
Query: 168 QQRNEE----------CDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAF 217
Q NE+ C FLI KE + + ++L + + RIS TFC+AF
Sbjct: 270 QVANEKLCSDVSNPGNCSCLTFLI--KECENTNIMKNLPQGTSQVPADLRISINTFCRAF 327
Query: 218 PFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFV 277
PFH++FD + V Q G + + L F +V P ++ +F +L ++T FV
Sbjct: 328 PFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFV 387
Query: 278 LRSKEGLLDVEKLECEDELTGTEIS--CLRLKGQMIYLPEADSILFLCSPSVMNLDDLTR 335
+R+K E +G+E + +KGQMI++PE++SILFL SP V LD+L
Sbjct: 388 IRTKP------------EASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMG 435
Query: 336 RGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLY 395
RGL+LSDIP+HDATRD++L+GEQ + + L + ++ L L+ T +ALE+EKKKT LLY
Sbjct: 436 RGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLY 495
Query: 396 SVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYT 455
S+ P VA +L + V A+++D+VT+LFS IVGF A C++ M+++++LN+LYT
Sbjct: 496 SIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCT----PMQVISMLNELYT 551
Query: 456 RFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQV-DG 514
RFD +YKVET+GD Y +GL + HA+ I +AL MME++ +V DG
Sbjct: 552 RFDHQCGFLD---IYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDG 608
Query: 515 ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMS 574
+Q+ IGIH+G V+ GV+G RMPRYCLFGN V L S+ E+ +INVS TY+ L
Sbjct: 609 RPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKR 668
Query: 575 PEN 577
E+
Sbjct: 669 EES 671
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 294 bits (752), Expect = 2e-79
Identities = 192/515 (37%), Positives = 281/515 (54%), Gaps = 28/515 (5%)
Query: 66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDAL-----HDHLATIYPGMRAPSF 120
I + G+ F C E + IL V+G +++FL + L H A + S
Sbjct: 132 IKESLGEEVFKICYEED-ENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASI 190
Query: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
C D E L ++Y+ + I+ GIIK A ++ TE+++ ++ D ++F+
Sbjct: 191 LCLDKEDDF-LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHN-DCSEFV 248
Query: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRV 239
+ + Q S + P + FCK FPFH +FD+D+ + Q GN I R+
Sbjct: 249 NQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRL 308
Query: 240 LPQLQ-PGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTG 298
+ + G + F ++ P I+ +F GI++ +N FV+R + V+K
Sbjct: 309 MNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSS------- 361
Query: 299 TEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQ 358
+ LKGQMIY+ E+ +ILFL SP V L+D T RGLYLSDIP+H+A RD+VL+GEQ
Sbjct: 362 ---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQ 418
Query: 359 FREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYD 418
R + L + L L L+ +ALE+EKKKT LL S+ P VA +L + V AK++
Sbjct: 419 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFS 478
Query: 419 NVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDK 478
NVT+LFS IVGF A CS+ + ++++ +LN LYTRFD VYKVET+GD
Sbjct: 479 NVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVETIGDA 531
Query: 479 YMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRM 537
Y GL + HA I +AL MME++ +V GE +++ IG+H+G V GV+G +M
Sbjct: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 538 PRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572
PRYCLFGN V L ++ E+ KINVS TYR L
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 294 bits (752), Expect = 2e-79
Identities = 192/515 (37%), Positives = 281/515 (54%), Gaps = 28/515 (5%)
Query: 66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDAL-----HDHLATIYPGMRAPSF 120
I + G+ F C E + IL V+G +++FL + L H A + S
Sbjct: 132 IKESLGEEVFKICYEED-ENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASI 190
Query: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
C D E L ++Y+ + I+ GIIK A ++ TE+++ ++ D ++F+
Sbjct: 191 LCLDKEDDF-LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHN-DCSEFV 248
Query: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRV 239
+ + Q S + P + FCK FPFH +FD+D+ + Q GN I R+
Sbjct: 249 NQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRL 308
Query: 240 LPQLQ-PGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTG 298
+ + G + F ++ P I+ +F GI++ +N FV+R + V+K
Sbjct: 309 MNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSS------- 361
Query: 299 TEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQ 358
+ LKGQMIY+ E+ +ILFL SP V L+D T RGLYLSDIP+H+A RD+VL+GEQ
Sbjct: 362 ---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQ 418
Query: 359 FREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYD 418
R + L + L L L+ +ALE+EKKKT LL S+ P VA +L + V AK++
Sbjct: 419 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFS 478
Query: 419 NVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDK 478
NVT+LFS IVGF A CS+ + ++++ +LN LYTRFD VYKVET+GD
Sbjct: 479 NVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVETIGDA 531
Query: 479 YMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRM 537
Y GL + HA I +AL MME++ +V GE +++ IG+H+G V GV+G +M
Sbjct: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 538 PRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572
PRYCLFGN V L ++ E+ KINVS TYR L
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 294 bits (752), Expect = 2e-79
Identities = 192/515 (37%), Positives = 281/515 (54%), Gaps = 28/515 (5%)
Query: 66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDAL-----HDHLATIYPGMRAPSF 120
I + G+ F C E + IL V+G +++FL + L H A + S
Sbjct: 132 IKESLGEEVFKICYEED-ENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASI 190
Query: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
C D E L ++Y+ + I+ GIIK A ++ TE+++ ++ D ++F+
Sbjct: 191 LCLDKEDDF-LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHN-DCSEFV 248
Query: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRV 239
+ + Q S + P + FCK FPFH +FD+D+ + Q GN I R+
Sbjct: 249 NQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRL 308
Query: 240 LPQLQ-PGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTG 298
+ + G + F ++ P I+ +F GI++ +N FV+R + V+K
Sbjct: 309 MNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSS------- 361
Query: 299 TEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQ 358
+ LKGQMIY+ E+ +ILFL SP V L+D T RGLYLSDIP+H+A RD+VL+GEQ
Sbjct: 362 ---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQ 418
Query: 359 FREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYD 418
R + L + L L L+ +ALE+EKKKT LL S+ P VA +L + V AK++
Sbjct: 419 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFS 478
Query: 419 NVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDK 478
NVT+LFS IVGF A CS+ + ++++ +LN LYTRFD VYKVET+GD
Sbjct: 479 NVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVETIGDA 531
Query: 479 YMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRM 537
Y GL + HA I +AL MME++ +V GE +++ IG+H+G V GV+G +M
Sbjct: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 538 PRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572
PRYCLFGN V L ++ E+ KINVS TYR L
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 294 bits (752), Expect = 2e-79
Identities = 192/515 (37%), Positives = 281/515 (54%), Gaps = 28/515 (5%)
Query: 66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDAL-----HDHLATIYPGMRAPSF 120
I + G+ F C E + IL V+G +++FL + L H A + S
Sbjct: 132 IKESLGEEVFKICYEED-ENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASI 190
Query: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
C D E L ++Y+ + I+ GIIK A ++ TE+++ ++ D ++F+
Sbjct: 191 LCLDKEDDF-LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHN-DCSEFV 248
Query: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRV 239
+ + Q S + P + FCK FPFH +FD+D+ + Q GN I R+
Sbjct: 249 NQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRL 308
Query: 240 LPQLQ-PGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTG 298
+ + G + F ++ P I+ +F GI++ +N FV+R + V+K
Sbjct: 309 MNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSS------- 361
Query: 299 TEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQ 358
+ LKGQMIY+ E+ +ILFL SP V L+D T RGLYLSDIP+H+A RD+VL+GEQ
Sbjct: 362 ---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQ 418
Query: 359 FREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYD 418
R + L + L L L+ +ALE+EKKKT LL S+ P VA +L + V AK++
Sbjct: 419 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFS 478
Query: 419 NVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDK 478
NVT+LFS IVGF A CS+ + ++++ +LN LYTRFD VYKVET+GD
Sbjct: 479 NVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVETIGDA 531
Query: 479 YMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRM 537
Y GL + HA I +AL MME++ +V GE +++ IG+H+G V GV+G +M
Sbjct: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 538 PRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572
PRYCLFGN V L ++ E+ KINVS TYR L
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 293 bits (749), Expect = 4e-79
Identities = 191/513 (37%), Positives = 280/513 (54%), Gaps = 28/513 (5%)
Query: 66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDAL-----HDHLATIYPGMRAPSF 120
I + G+ F C E + IL V+G +++FL + L H A + S
Sbjct: 132 IKESLGEEVFKICYEED-ENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASI 190
Query: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
C D E L ++Y+ + I+ GIIK A ++ TE+++ ++ D ++F+
Sbjct: 191 LCLDKEDDF-LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHN-DCSEFV 248
Query: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRV 239
+ + Q S + P + FCK FPFH +FD+D+ + Q GN I R+
Sbjct: 249 NQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRL 308
Query: 240 LPQLQ-PGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTG 298
+ + G + F ++ P I+ +F GI++ +N FV+R + V+K
Sbjct: 309 MNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSS------- 361
Query: 299 TEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQ 358
+ LKGQMIY+ E+ +ILFL SP V L+D T RGLYLSDIP+H+A RD+VL+GEQ
Sbjct: 362 ---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQ 418
Query: 359 FREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYD 418
R + L + L L L+ +ALE+EKKKT LL S+ P VA +L + V AK++
Sbjct: 419 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFS 478
Query: 419 NVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDK 478
NVT+LFS IVGF A CS+ + ++++ +LN LYTRFD VYKVET+GD
Sbjct: 479 NVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVETIGDA 531
Query: 479 YMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRM 537
Y GL + HA I +AL MME++ +V GE +++ IG+H+G V GV+G +M
Sbjct: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 538 PRYCLFGNTVNLTSRTETTGEKGKINVSEYTYR 570
PRYCLFGN V L ++ E+ KINVS TYR
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYR 624
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 275 bits (703), Expect = 9e-74
Identities = 162/372 (43%), Positives = 225/372 (60%), Gaps = 20/372 (5%)
Query: 204 QESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQ-PGNCSLLSVFSLVRPHI 261
Q S + P + FCK FPFH +FD+D+ + Q GN I R++ + G + F ++ P I
Sbjct: 37 QSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKI 96
Query: 262 DISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILF 321
+ +F GI++ +N FV+R + V+K + LKGQMIY+ E+ +ILF
Sbjct: 97 NQTFSGIMTMLNMQFVVRVRRWDNSVKKSS----------RVMDLKGQMIYIVESSAILF 146
Query: 322 LCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLR 381
L SP V L+D T RGLYLSDIP+H+A RD+VL+GEQ R + L + L L L+ +
Sbjct: 147 LGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQ 206
Query: 382 ALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGE 441
ALE+EKKKT LL S+ P VA +L + V AK++ NVT+LFS IVGF A CS+ +
Sbjct: 207 ALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCS--- 263
Query: 442 GAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLAL 501
++++ +LN LYTRFD VYKVET+GD Y GL + HA I +AL
Sbjct: 264 -PLQVITMLNALYTRFDQQCGELD---VYKVETIGDAYCVAGGLHKESDTHAVQIALMAL 319
Query: 502 DMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKG 560
MME++ +V GE +++ IG+H+G V GV+G +MPRYCLFGN V L ++ E+
Sbjct: 320 KMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPR 379
Query: 561 KINVSEYTYRCL 572
KINVS TYR L
Sbjct: 380 KINVSPTTYRLL 391
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 173 bits (438), Expect = 5e-43
Identities = 109/255 (42%), Positives = 147/255 (57%), Gaps = 20/255 (7%)
Query: 361 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV 420
E+Y E E++ +R Q L +EK+K + LLY +LP SVA +L+ V A+ +D+V
Sbjct: 821 EQYANNLE-ELVEERTQAYL----EEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSV 875
Query: 421 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM 480
TI FS IVGF A ++ M++V LLNDLYT FD + D N VYKVET+GD YM
Sbjct: 876 TIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVID---NFDVYKVETIGDAYM 928
Query: 481 TVSGLP-EPCIHHARSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQR 536
VSGLP HA + +AL +++ ++ E +++ IGIHTG V GV+G +
Sbjct: 929 VVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLK 988
Query: 537 MPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKK 596
MPRYCLFG+TVN SR E+ GE KI++S T L F LE RG V MKGK
Sbjct: 989 MPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL----EEFGGFELELRGDVEMKGKG 1044
Query: 597 EPMQVWFLSRKNTGT 611
+ W L + + T
Sbjct: 1045 KVRTYWLLGERGSST 1059
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 170 bits (431), Expect = 3e-42
Identities = 101/231 (43%), Positives = 137/231 (59%), Gaps = 15/231 (6%)
Query: 381 RALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASG 440
+A +EK+K + LLY +LP SVA +L+ V A+ +D+VTI FS IVGF A ++
Sbjct: 821 QAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTP- 879
Query: 441 EGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP-EPCIHHARSICHL 499
M++V LLNDLYT FD + D N VYKVET+GD YM VSGLP HA I +
Sbjct: 880 ---MQVVTLLNDLYTCFDAIID---NFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARM 933
Query: 500 ALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETT 556
AL +++ ++ + +++ IG+HTG V GV+G +MPRYCLFG+TVN SR E+
Sbjct: 934 ALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESN 993
Query: 557 GEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRK 607
G+ KI+VS T L + F LE RG V MKGK + W L +
Sbjct: 994 GQALKIHVSSTTKDAL----DELGCFQLELRGDVEMKGKGKMRTYWLLGER 1040
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 160 bits (406), Expect = 2e-39
Identities = 101/247 (40%), Positives = 139/247 (56%), Gaps = 14/247 (5%)
Query: 365 LTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILF 424
L Q L D ++ LE EK+KT+ LL +LPPSVA L+ V + +D VT+ F
Sbjct: 828 LEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYF 887
Query: 425 SGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSG 484
S IVGF + +++V+LLNDLYT FD + S VYKVET+GD YM SG
Sbjct: 888 SDIVGFTTISAMSEP----IEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASG 940
Query: 485 LPEPC-IHHARSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRY 540
LP+ HA I +++LD++ G ++ V+I IG+H+G VV GV+G MPRY
Sbjct: 941 LPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRY 1000
Query: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ 600
CLFG+TVN SR E+TG +I+VS T L +N + +E RG +KGK
Sbjct: 1001 CLFGDTVNTASRMESTGLPYRIHVSLSTVTIL---QNLSEGYEVELRGRTELKGKGTEET 1057
Query: 601 VWFLSRK 607
W + +K
Sbjct: 1058 FWLIGKK 1064
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 160 bits (405), Expect = 3e-39
Identities = 102/258 (39%), Positives = 141/258 (54%), Gaps = 14/258 (5%)
Query: 365 LTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILF 424
L Q L D ++ LE EK+KTD LL +LPPSVA L+ PV + ++ VT+ F
Sbjct: 824 LEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYF 883
Query: 425 SGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSG 484
S IVGF + +++V+LLNDLYT FD + S VYKVET+GD YM SG
Sbjct: 884 SDIVGFTTISAMSEP----IEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASG 936
Query: 485 LPEPC-IHHARSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRY 540
LP+ HA I +++LD++ G ++ V+I IG+H+G V GV+G MPRY
Sbjct: 937 LPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRY 996
Query: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ 600
CLFG+TVN SR E+TG +I+V+ T L + D + +E RG +KGK
Sbjct: 997 CLFGDTVNTASRMESTGLPYRIHVNLSTVGILRA---LDSGYQVELRGRTELKGKGAEDT 1053
Query: 601 VWFLSRKNTGTEETKQDD 618
W + R+ K D
Sbjct: 1054 FWLVGRRGFNKPIPKPPD 1071
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 150 bits (380), Expect = 3e-36
Identities = 101/270 (37%), Positives = 145/270 (53%), Gaps = 30/270 (11%)
Query: 354 LLGEQFREEYKLTQELEILTDRLQLTLRALED-----------EKKKTDTLLYSVLPPSV 402
L +Q E Y ++ L RLQL R LE E+ + D L + +LP V
Sbjct: 751 LFHDQKNESY-----MDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLV 805
Query: 403 ANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTD 462
L+ K V + Y+ VTI FS IVGF C K+++ M++V++LND+Y FD + D
Sbjct: 806 VKSLKEKGFVEPELYEEVTIYFSDIVGFTTIC-KYST---PMEVVDMLNDIYKSFDHIVD 861
Query: 463 SRKNPFVYKVETVGDKYMTVSGLPEPCIH-HARSICHLALDMMEIAGQVQVD---GESVQ 518
VYKVET+GD YM SGLP+ + HA I +AL+++ G +++ G +
Sbjct: 862 HHD---VYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIW 918
Query: 519 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS 578
I IG+H+G GV+G +MPRYCLFG+TVN SR E+TG +I+VS T L + +
Sbjct: 919 IRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL---KRT 975
Query: 579 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKN 608
+ QF E RG +KG+ W K+
Sbjct: 976 ECQFLYEVRGETYLKGRGNETTYWLTGMKD 1005
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 115 bits (288), Expect = 1e-25
Identities = 77/229 (33%), Positives = 123/229 (53%), Gaps = 28/229 (12%)
Query: 367 QELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRH---KRP------VPAKRY 417
Q + DRL+L EDE +K + LL S+LP +VA E++ K P + +R+
Sbjct: 245 QARSCIEDRLRL-----EDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRH 299
Query: 418 DNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGD 477
DNV+ILF+ IVGF S+ A ++V LLN+L+ +FD L +++ +GD
Sbjct: 300 DNVSILFADIVGFTGLASQCT----AQELVKLLNELFGKFDELATENH---CRRIKILGD 352
Query: 478 KYMTVSGLPEPCIHHARSICHLALDMME----IAGQVQVDGESVQITIGIHTGEVVTGVI 533
Y VSGL +P HA + LDM++ +A +VD + + +G+HTG V+ GV+
Sbjct: 353 CYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVD---LNMRVGLHTGRVLCGVL 409
Query: 534 GQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQF 582
G R +Y ++ N V L + E G GK+++++ T CL +P +
Sbjct: 410 GLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGY 458
Score = 110 bits (274), Expect = 5e-24
Identities = 73/240 (30%), Positives = 119/240 (49%), Gaps = 21/240 (8%)
Query: 386 EKKKTDT--LLYSVLPPSVANELRHKRP----VPAKRYDNVTILFSGIVGFNAFCSKHAS 439
EK K D +L+++LP VA P + + Y V ++F+ I FN F +
Sbjct: 827 EKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDG 886
Query: 440 GEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP--------EPCIH 491
++ + LLN++ FD L + + K++T+G YM GL +
Sbjct: 887 NNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISS 946
Query: 492 HARSICHLALDMMEIAGQVQVDG-ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLT 550
H ++ A++M ++ ++ + +GI+ G VV GVIG R P+Y ++GNTVN+
Sbjct: 947 HLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVA 1006
Query: 551 SRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTG 610
SR ++TG +G+I V+E +R L +H RG VS+KGK E M +FL + G
Sbjct: 1007 SRMDSTGVQGRIQVTEEVHRLLRR-----CPYHFVCRGKVSVKGKGE-MLTYFLEGRTDG 1060
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 110 bits (275), Expect = 4e-24
Identities = 70/229 (30%), Positives = 117/229 (51%), Gaps = 16/229 (6%)
Query: 380 LRALEDEKKKTDTLLYSVLPPSVANEL----RHKRPVPAKRYDNVTILFSGIVGFNAFCS 435
+ +++ ++ + +L ++LP VA R + ++ YD V ++F+ I GF F S
Sbjct: 937 INEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYS 996
Query: 436 KHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP---EPCIHH 492
+ ++ + LLN++ FD L + + K++T+G YM VSGL + C
Sbjct: 997 QTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDK 1056
Query: 493 ARSICHLALDMMEIAGQVQVDGE----SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVN 548
+C LA + + +Q + + ++ IGI G VV GVIG + P+Y ++G TVN
Sbjct: 1057 WGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVN 1116
Query: 549 LTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKE 597
L SR ++TG G+I V E TY L D F ++RG + +KG E
Sbjct: 1117 LASRMDSTGVSGRIQVPEETYLIL-----KDQGFAFDYRGEIYVKGISE 1160
Score = 96.7 bits (239), Expect = 6e-20
Identities = 75/251 (29%), Positives = 124/251 (49%), Gaps = 35/251 (13%)
Query: 383 LEDEKKKTDTLLYSVLPPSVANE------------LRHK-RPVPAKRYDNVTILFSGIVG 429
LE E ++ + L+ SVLP V E L+H+ + RY+NV+ILF+ + G
Sbjct: 363 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422
Query: 430 FNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPC 489
F + + A ++V +LN+L+ RFD L +++ +GD Y VSGLPEP
Sbjct: 423 FTNLSTTLS----AQELVRMLNELFARFDRLAHEHH---CLRIKILGDCYYCVSGLPEPR 475
Query: 490 IHHARSICHLALDMMEIAGQVQVDGE-SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVN 548
HA + L M++ V+ + V + IGIH+G V+ GV+G R ++ ++ V+
Sbjct: 476 QDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVD 535
Query: 549 LTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKN 608
+ ++ E+ G G+I++S+ T CL N + + H + R FL + N
Sbjct: 536 IANKLESGGIPGRIHISKATLDCLNGDYNVE-EGHGKERNE-------------FLRKHN 581
Query: 609 TGTEETKQDDD 619
T KQ +D
Sbjct: 582 IETYLIKQPED 592
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 105 bits (263), Expect = 9e-23
Identities = 72/224 (32%), Positives = 113/224 (50%), Gaps = 41/224 (18%)
Query: 383 LEDEKKKTDTLLYSVLPPSVANEL-------------RHK-------------------- 409
LE EK + +++SV+P +A++L RH
Sbjct: 323 LEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAF 382
Query: 410 RPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFV 469
RP ++ + V+ILF+ IVGF +K ++ + A +V LLNDL+ RFD L + K
Sbjct: 383 RPFKMQQIEEVSILFADIVGF----TKMSANKSAHALVGLLNDLFGRFDRLCEETK---C 435
Query: 470 YKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEV 528
K+ T+GD Y V+G PEP HA + L M++ Q Q E V + +G+HTG V
Sbjct: 436 EKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTV 495
Query: 529 VTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572
+ G++G R ++ ++ N VNL + E G GK+++SE T + L
Sbjct: 496 LCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539
Score = 100 bits (248), Expect = 5e-21
Identities = 70/250 (28%), Positives = 126/250 (50%), Gaps = 20/250 (8%)
Query: 355 LGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPA 414
L +F Y+L ++ D + ++++ D+ D LL +++P VA +L+ + +
Sbjct: 996 LNREFEVSYRLHYHGDVEADLHRTKIQSMRDQ---ADWLLRNIIPYHVAEQLKVSQTY-S 1051
Query: 415 KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVET 474
K +D+ ++F+ IV F+ F ++ EG + +LN+L FD L + K++T
Sbjct: 1052 KNHDSGGVIFASIVNFSEFYEENY--EGGKECYRVLNELIGDFDELLSKPDYSSIEKIKT 1109
Query: 475 VGDKYMTVSGLPEPCIH-------HARSICHLALDMMEIAGQVQVD--GESVQITIGIHT 525
+G YM SGL H + + A +MM + + + ++ +G +
Sbjct: 1110 IGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNH 1169
Query: 526 GEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLE 585
G + GVIG Y ++G+TVN+ SR +TTG + +I VSE +YR L S + +
Sbjct: 1170 GPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVL-----SKMGYDFD 1224
Query: 586 HRGPVSMKGK 595
+RG V++KGK
Sbjct: 1225 YRGTVNVKGK 1234
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 105 bits (261), Expect = 2e-22
Identities = 67/209 (32%), Positives = 109/209 (52%), Gaps = 18/209 (8%)
Query: 383 LEDEKKKTDTLLYSVLPPSVANELRHK----------RPVPAKRYDNVTILFSGIVGFNA 432
L+ E ++ + LL SVLP VA E++ + +++DNV+ILF+ I GF +
Sbjct: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
Query: 433 FCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHH 492
S+ A ++V LN+L+ RFD L +++ +GD Y VSGLPE H
Sbjct: 391 LASQCT----AQELVMTLNELFARFDKLAAENH---CLRIKILGDCYYCVSGLPEARADH 443
Query: 493 ARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTS 551
A + +DM+E V +V G +V + +GIH+G V GV+G R ++ ++ N V L +
Sbjct: 444 AHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLAN 503
Query: 552 RTETTGEKGKINVSEYTYRCLMSPENSDP 580
E G G+I+++ T + L +P
Sbjct: 504 HMEAGGRAGRIHITRATLQYLNGDYEVEP 532
Score = 100 bits (248), Expect = 5e-21
Identities = 74/257 (28%), Positives = 129/257 (50%), Gaps = 19/257 (7%)
Query: 361 EEYKLTQELEILTDRLQLT--LRALEDEKKKTDTLLYSVLPPSVANEL----RHKRPVPA 414
++ + T L+ L +LQ T +E+ + LL+++LP VA R +
Sbjct: 914 QQVESTARLDFLW-KLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 972
Query: 415 KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVET 474
+ + V ++F+ I F+ F + + ++ + LLN++ FD + + + K++T
Sbjct: 973 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 1032
Query: 475 VGDKYMTVSGLPEPCIH-----HARSICHLALDMMEIAGQVQVDG-ESVQITIGIHTGEV 528
+G YM SGL H ++ A+ +ME + + Q+ IG++ G V
Sbjct: 1033 IGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPV 1092
Query: 529 VTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRG 588
V GVIG R P+Y ++GNTVN++SR ++TG +I V+ Y+ L + + LE RG
Sbjct: 1093 VAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAA-----KGYQLECRG 1147
Query: 589 PVSMKGKKEPMQVWFLS 605
V +KGK E M +FL+
Sbjct: 1148 VVKVKGKGE-MTTYFLN 1163
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 105 bits (261), Expect = 2e-22
Identities = 67/209 (32%), Positives = 109/209 (52%), Gaps = 18/209 (8%)
Query: 383 LEDEKKKTDTLLYSVLPPSVANELRHK----------RPVPAKRYDNVTILFSGIVGFNA 432
L+ E ++ + LL SVLP VA E++ + +++DNV+ILF+ I GF +
Sbjct: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
Query: 433 FCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHH 492
S+ A ++V LN+L+ RFD L +++ +GD Y VSGLPE H
Sbjct: 391 LASQCT----AQELVMTLNELFARFDKLAAENH---CLRIKILGDCYYCVSGLPEARADH 443
Query: 493 ARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTS 551
A + +DM+E V +V G +V + +GIH+G V GV+G R ++ ++ N V L +
Sbjct: 444 AHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLAN 503
Query: 552 RTETTGEKGKINVSEYTYRCLMSPENSDP 580
E G G+I+++ T + L +P
Sbjct: 504 HMEAGGRAGRIHITRATLQYLNGDYEVEP 532
Score = 100 bits (248), Expect = 5e-21
Identities = 74/257 (28%), Positives = 129/257 (50%), Gaps = 19/257 (7%)
Query: 361 EEYKLTQELEILTDRLQLT--LRALEDEKKKTDTLLYSVLPPSVANEL----RHKRPVPA 414
++ + T L+ L +LQ T +E+ + LL+++LP VA R +
Sbjct: 861 QQVESTARLDFLW-KLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 919
Query: 415 KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVET 474
+ + V ++F+ I F+ F + + ++ + LLN++ FD + + + K++T
Sbjct: 920 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 979
Query: 475 VGDKYMTVSGLPEPCIH-----HARSICHLALDMMEIAGQVQVDG-ESVQITIGIHTGEV 528
+G YM SGL H ++ A+ +ME + + Q+ IG++ G V
Sbjct: 980 IGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPV 1039
Query: 529 VTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRG 588
V GVIG R P+Y ++GNTVN++SR ++TG +I V+ Y+ L + + LE RG
Sbjct: 1040 VAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAA-----KGYQLECRG 1094
Query: 589 PVSMKGKKEPMQVWFLS 605
V +KGK E M +FL+
Sbjct: 1095 VVKVKGKGE-MTTYFLN 1110
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 103 bits (256), Expect = 6e-22
Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 37/280 (13%)
Query: 363 YKLTQELEILTDRLQLTLRALEDEKKKT-------DTLLYSVLPPSVANEL----RHKRP 411
Y ++ +E L L L + D+K++ + L+ ++LP VA +
Sbjct: 854 YYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEE 913
Query: 412 VPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYK 471
+ ++ YD + ++F+ + F F ++ + G ++ + LN++ + FD+L D+ K + K
Sbjct: 914 LYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITK 973
Query: 472 VETVGDKYMTVSGLPEPCIH-------------------HARSICHLALDMMEIAGQVQV 512
++T+G YM SG+ P ++ H + AL M + +
Sbjct: 974 IKTIGSTYMAASGVT-PDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINN 1032
Query: 513 DG-ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRC 571
+ + IG++ G V+ GVIG R P Y ++GNTVN+ SR E+TG G I V E T
Sbjct: 1033 QSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVI 1092
Query: 572 LMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGT 611
L + F RGP+ +KGK E + + R T
Sbjct: 1093 L-----REYGFRFVRRGPIFVKGKGELLTFFLKGRDKLAT 1127
Score = 97.8 bits (242), Expect = 3e-20
Identities = 64/212 (30%), Positives = 113/212 (53%), Gaps = 21/212 (9%)
Query: 383 LEDEKKKTDTLLYSVLPPSVANELRH--KRPVPAK-----------RYDNVTILFSGIVG 429
LE++ ++ + L+ S+LP VA+E+ K+ K R++NV+ILF+ IVG
Sbjct: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
Query: 430 FNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPC 489
F +S A ++V LLN+L+ RFD L +++ +GD Y + GLP+
Sbjct: 328 FTQL----SSACSAQELVKLLNELFARFDKLAAKYHQ---LRIKILGDCYYCICGLPDYR 380
Query: 490 IHHARSICHLALDMMEIAGQVQVDGES-VQITIGIHTGEVVTGVIGQRMPRYCLFGNTVN 548
HA + L M+E V+ ++ V + +G+HTG V+ GV+GQ+ +Y ++ V
Sbjct: 381 EDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVT 440
Query: 549 LTSRTETTGEKGKINVSEYTYRCLMSPENSDP 580
+ ++ E G G++++S+ T CL + +P
Sbjct: 441 VANKMEAGGIPGRVHISQSTMDCLKGEFDVEP 472
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 103 bits (256), Expect = 6e-22
Identities = 68/208 (32%), Positives = 110/208 (52%), Gaps = 22/208 (10%)
Query: 386 EKKKTDTLLYSVLPPSVANELR------------HKRPVPAKRYDNVTILFSGIVGFNAF 433
E ++ + LL SVLP VA E++ HK + +++DNV+ILF+ I GF +
Sbjct: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHK--IYIQKHDNVSILFADIEGFTSL 481
Query: 434 CSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHA 493
S+ A ++V LN+L+ RFD L +++ +GD Y VSGLPE HA
Sbjct: 482 ASQCT----AQELVMTLNELFARFDKLAAENH---CLRIKILGDCYYCVSGLPEARADHA 534
Query: 494 RSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSR 552
+ +DM+E V +V G +V + +GIH+G V GV+G R ++ ++ N V L +
Sbjct: 535 HCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH 594
Query: 553 TETTGEKGKINVSEYTYRCLMSPENSDP 580
E G+ G+I++++ T L +P
Sbjct: 595 MEAGGKAGRIHITKATLNYLNGDYEVEP 622
Score = 100 bits (250), Expect = 3e-21
Identities = 73/257 (28%), Positives = 130/257 (50%), Gaps = 19/257 (7%)
Query: 361 EEYKLTQELEILTDRLQLT--LRALEDEKKKTDTLLYSVLPPSVANEL----RHKRPVPA 414
++ + T L+ L +LQ T +E+ + LL+++LP VA R +
Sbjct: 1006 QQVESTARLDFLW-KLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 1064
Query: 415 KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVET 474
+ + V ++F+ I F+ F + + ++ + LLN++ FD + + + K++T
Sbjct: 1065 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKT 1124
Query: 475 VGDKYMTVSGLPEPCIH-----HARSICHLALDMMEIAGQVQVDG-ESVQITIGIHTGEV 528
+G YM SGL + H +++ A+ +M+ + + Q+ IG++ G V
Sbjct: 1125 IGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPV 1184
Query: 529 VTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRG 588
V GVIG R P+Y ++GNTVN+ SR ++TG +I V+ Y+ L + + LE RG
Sbjct: 1185 VAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAA-----NTYQLECRG 1239
Query: 589 PVSMKGKKEPMQVWFLS 605
V +KGK E M +FL+
Sbjct: 1240 VVKVKGKGE-MMTYFLN 1255
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 102 bits (254), Expect = 1e-21
Identities = 67/212 (31%), Positives = 114/212 (53%), Gaps = 27/212 (12%)
Query: 381 RALEDEKKKTDTLLYSVLPPSVANELR-----------HKRPVP--------AKRYDNVT 421
R L EK++ + LL SVLP ++ ++ +R +P KR+ NV+
Sbjct: 220 RKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVS 279
Query: 422 ILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMT 481
IL++ IVGF S + E +V +LN+L+ +FD + + + +++ +GD Y
Sbjct: 280 ILYADIVGFTQLASDCSPKE----LVVVLNELFGKFDQIAKANE---CMRIKILGDCYYC 332
Query: 482 VSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRY 540
VSGLP HAR+ + LDM + QV + G + + +GIH+G V+ GVIG R +Y
Sbjct: 333 VSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQY 392
Query: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572
++ + V+L +R E G G+++++E T + L
Sbjct: 393 DVWSHDVSLANRMEAAGVPGRVHITEATLKHL 424
Score = 100 bits (248), Expect = 5e-21
Identities = 71/219 (32%), Positives = 112/219 (51%), Gaps = 19/219 (8%)
Query: 393 LLYSVLPPSVANEL---RHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNL 449
LL +VLP VA + + YD V ++F+ + F F ++ + ++ + L
Sbjct: 848 LLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRL 907
Query: 450 LNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSI----CHLALDM-M 504
LN++ FD L K V K++T+G YM +GL H + + H+ + +
Sbjct: 908 LNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEF 967
Query: 505 EIAGQVQVDG------ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGE 558
IA ++DG S ++ +GI+ G V+ GVIG R P+Y ++GNTVN+ SR E+TGE
Sbjct: 968 SIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGE 1027
Query: 559 KGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKE 597
GKI V+E T L + E RG +++KGK E
Sbjct: 1028 LGKIQVTEETCTILQG-----LGYSCECRGLINVKGKGE 1061
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 100 bits (248), Expect = 5e-21
Identities = 62/206 (30%), Positives = 110/206 (53%), Gaps = 27/206 (13%)
Query: 383 LEDEKKKTDTLLYSVLPPSVANELRHK-------------------RPVPAKRYDNVTIL 423
LE EK++ + LL S+LP +A E++ + + KR+ NV+IL
Sbjct: 233 LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSIL 292
Query: 424 FSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVS 483
++ IVGF S + GE +V++LN+L+ +FD + + +++ +GD Y VS
Sbjct: 293 YADIVGFTRLASDCSPGE----LVHMLNELFGKFDQIAKENE---CMRIKILGDCYYCVS 345
Query: 484 GLPEPCIHHARSICHLALDMMEIAGQVQ-VDGESVQITIGIHTGEVVTGVIGQRMPRYCL 542
GLP +HA++ + LDM E +V+ G + + +G+H+G V+ GVIG + +Y +
Sbjct: 346 GLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDV 405
Query: 543 FGNTVNLTSRTETTGEKGKINVSEYT 568
+ + V L + E G G++++S T
Sbjct: 406 WSHDVTLANHMEAGGVPGRVHISSVT 431
Score = 89.0 bits (219), Expect = 1e-17
Identities = 75/271 (27%), Positives = 133/271 (49%), Gaps = 27/271 (9%)
Query: 352 LVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHK-- 409
L++LG Q EY + + ++ + +E + LL +VLP VA +
Sbjct: 817 LLVLGRQ--NEYYCRLDF-LWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSL 873
Query: 410 --RPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNP 467
+ + YD V ++F+ I F F ++ + ++ + LLN++ FD L K
Sbjct: 874 KNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFS 933
Query: 468 FVYKVETVGDKYMTVSGLPE-PCIHHA----RSICHLALDMMEIA----GQVQVDGE--- 515
V K++T+G YM +GL P H+ R H+ M+E A G++ +
Sbjct: 934 GVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGT-MVEFAFALVGKLDAINKHSF 992
Query: 516 -SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMS 574
++ +GI+ G V+ GVIG + P+Y ++GNTVN+ SR ++TG KI V+E T L +
Sbjct: 993 NDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQT 1052
Query: 575 PENSDPQFHLEHRGPVSMKGKKEPMQVWFLS 605
+ RG +++KGK + ++ +F++
Sbjct: 1053 -----LGYTCTCRGIINVKGKGD-LKTYFVN 1077
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 99.4 bits (246), Expect = 9e-21
Identities = 80/255 (31%), Positives = 127/255 (49%), Gaps = 31/255 (12%)
Query: 381 RALEDEKKKTDT-------LLYSVLPPSVANEL----RHKRPVPAKRYDNVTILFSGIVG 429
+ L E+++T+T LL +VLP VA + R + + Y+ V +LF+ +
Sbjct: 822 KKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPD 881
Query: 430 FNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPC 489
F F S+ ++ + LLN++ FD L K V K++T+G YM +GL
Sbjct: 882 FKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATS 941
Query: 490 IHHA-----RSICHLALDMMEIA----GQVQVDGE----SVQITIGIHTGEVVTGVIGQR 536
A RS HL M+E A ++ V + + ++ +G++ G VV GVIG +
Sbjct: 942 GQDAQQDAERSCSHLGT-MVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
Query: 537 MPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKK 596
P+Y ++GNTVN+ SR E+TG GKI V+E T L S + RG + +KGK
Sbjct: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQS-----LGYTCYSRGVIKVKGKG 1055
Query: 597 EPMQVWFLSRKNTGT 611
+ + +FL+ T T
Sbjct: 1056 Q-LCTYFLNTDLTRT 1069
Score = 92.0 bits (227), Expect = 1e-18
Identities = 64/229 (27%), Positives = 116/229 (50%), Gaps = 28/229 (12%)
Query: 381 RALEDEKKKTDTLLYSVLPPSVANELRHK-----------RP--------VPAKRYDNVT 421
R L+ EKK + LL S+LP +A E++ + RP + KR+ V+
Sbjct: 214 RRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVS 273
Query: 422 ILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMT 481
+L++ IVGF S+ + E +V +LN+L+ +FD + + +++ +GD Y
Sbjct: 274 VLYADIVGFTRLASECSPKE----LVLMLNELFGKFDQIAKEHE---CMRIKILGDCYYC 326
Query: 482 VSGLPEPCIHHARSICHLALDMMEIAGQVQV-DGESVQITIGIHTGEVVTGVIGQRMPRY 540
VSGLP HA + + LDM +++ G + + +G+H+G V+ GVIG + +Y
Sbjct: 327 VSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQY 386
Query: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGP 589
++ + V L + E G G+++++ T L++ + +EHR P
Sbjct: 387 DVWSHDVTLANHMEAGGVPGRVHITGATL-ALLAGAYAVEDAGMEHRDP 434
>gi|194595480 guanylate cyclase 1, soluble, alpha 3 isoform C [Homo
sapiens]
Length = 366
Score = 76.6 bits (187), Expect = 6e-14
Identities = 61/231 (26%), Positives = 107/231 (46%), Gaps = 10/231 (4%)
Query: 66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDAL-----HDHLATIYPGMRAPSF 120
I + G+ F C E + IL V+G +++FL + L H A + S
Sbjct: 132 IKESLGEEVFKICYEED-ENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASI 190
Query: 121 RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL 180
C D E L ++Y+ + I+ GIIK A ++ TE+++ ++ D ++F+
Sbjct: 191 LCLDKEDDF-LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHN-DCSEFV 248
Query: 181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRV 239
+ + Q S + P + FCK FPFH +FD+D+ + Q GN I R+
Sbjct: 249 NQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRL 308
Query: 240 LPQLQ-PGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEK 289
+ + G + F ++ P I+ +F GI++ +N FV+R + V+K
Sbjct: 309 MNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKK 359
>gi|170650672 Leber congenital amaurosis 5 [Homo sapiens]
Length = 697
Score = 34.7 bits (78), Expect = 0.27
Identities = 38/150 (25%), Positives = 67/150 (44%), Gaps = 13/150 (8%)
Query: 268 ILSHINTVFVLRS-------KEGLLDVEKLECEDELTGTEISCLRLK--GQMIYLPEADS 318
I H N + L+ KE + + E EL T+ S +LK + +LPE D
Sbjct: 161 IFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDD 220
Query: 319 ILFLCSPSVMNLDDLTRRGLYLS-DIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQ 377
+ + + LDD RR LS ++ L + LL E+ + Y+ E ++L +Q
Sbjct: 221 LAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAER-KRAYEAHDENKVLQKEVQ 279
Query: 378 LTLRALEDEKKKTD--TLLYSVLPPSVANE 405
L++++++ D + + LP S N+
Sbjct: 280 RLYHKLKEKERELDIKNIYSNRLPKSSPNK 309
>gi|170650670 Leber congenital amaurosis 5 [Homo sapiens]
Length = 697
Score = 34.7 bits (78), Expect = 0.27
Identities = 38/150 (25%), Positives = 67/150 (44%), Gaps = 13/150 (8%)
Query: 268 ILSHINTVFVLRS-------KEGLLDVEKLECEDELTGTEISCLRLK--GQMIYLPEADS 318
I H N + L+ KE + + E EL T+ S +LK + +LPE D
Sbjct: 161 IFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDD 220
Query: 319 ILFLCSPSVMNLDDLTRRGLYLS-DIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQ 377
+ + + LDD RR LS ++ L + LL E+ + Y+ E ++L +Q
Sbjct: 221 LAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAER-KRAYEAHDENKVLQKEVQ 279
Query: 378 LTLRALEDEKKKTD--TLLYSVLPPSVANE 405
L++++++ D + + LP S N+
Sbjct: 280 RLYHKLKEKERELDIKNIYSNRLPKSSPNK 309
>gi|22749047 coiled-coil domain containing 24 [Homo sapiens]
Length = 307
Score = 31.6 bits (70), Expect = 2.3
Identities = 22/87 (25%), Positives = 41/87 (47%), Gaps = 2/87 (2%)
Query: 326 SVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALED 385
+V N+D + R L + H R++++L EEY + L+ TL L++
Sbjct: 154 NVSNIDQVARHLRGLLEEECHTLEREILILQRCLEEEY--LRPCHPSEAALEPTLAELKE 211
Query: 386 EKKKTDTLLYSVLPPSVANELRHKRPV 412
+KK + L + + PS + +RP+
Sbjct: 212 QKKAMEQELQASVGPSCVSPNHRQRPL 238
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 30.8 bits (68), Expect = 3.9
Identities = 29/106 (27%), Positives = 46/106 (43%), Gaps = 9/106 (8%)
Query: 131 LILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKE----- 185
LI +E L DI++ IK Q+ T K++QQ + CD + L+ +E
Sbjct: 355 LICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQ 414
Query: 186 SKE--EDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVV 229
SKE + +D++ F E P T + F +I +L V
Sbjct: 415 SKEDAQKALQDIENFLEMALPFINYEPETL--QYEFDVILSPELKV 458
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 30.8 bits (68), Expect = 3.9
Identities = 29/106 (27%), Positives = 46/106 (43%), Gaps = 9/106 (8%)
Query: 131 LILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKE----- 185
LI +E L DI++ IK Q+ T K++QQ + CD + L+ +E
Sbjct: 295 LICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQ 354
Query: 186 SKE--EDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVV 229
SKE + +D++ F E P T + F +I +L V
Sbjct: 355 SKEDAQKALQDIENFLEMALPFINYEPETL--QYEFDVILSPELKV 398
>gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo
sapiens]
Length = 492
Score = 30.8 bits (68), Expect = 3.9
Identities = 32/129 (24%), Positives = 56/129 (43%), Gaps = 8/129 (6%)
Query: 273 NTVFVLRSKEGLLDVEKLECEDELTGTEISCLRL-KGQMIYLPEADSILFLCSPSVMNLD 331
NT+F LR + +L C +E E+ CL L K +Y ++IL + D
Sbjct: 299 NTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERD 358
Query: 332 D--LTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALED--EK 387
TR L+ ++ L +Q RE + EL++ + + L A+E +
Sbjct: 359 QAIATREELHAQHA---RGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRR 415
Query: 388 KKTDTLLYS 396
++ +TL+ S
Sbjct: 416 QQLETLVLS 424
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,392,862
Number of Sequences: 37866
Number of extensions: 1052043
Number of successful extensions: 3199
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3052
Number of HSP's gapped (non-prelim): 53
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.