BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] (912 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 1863 0.0 gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 1411 0.0 gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 1392 0.0 gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 1316 0.0 gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 1305 0.0 gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 1248 0.0 gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 731 0.0 gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 726 0.0 gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 656 0.0 gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 656 0.0 gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 655 0.0 gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 655 0.0 gi|37577159 calcium-sensing receptor [Homo sapiens] 409 e-114 gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 245 2e-64 gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 241 2e-63 gi|112807234 G protein-coupled receptor, family C, group 6, memb... 239 9e-63 gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 211 3e-54 gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ... 210 6e-54 gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 135 1e-31 gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 122 2e-27 gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 65 3e-10 gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 65 3e-10 gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 65 3e-10 gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 64 6e-10 gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] 57 6e-08 gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 48 5e-05 gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 48 5e-05 gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 48 5e-05 gi|7706451 G protein-coupled receptor, family C, group 5, member... 47 1e-04 gi|93204867 G protein-coupled receptor 158 [Homo sapiens] 45 4e-04 >gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] Length = 912 Score = 1863 bits (4826), Expect = 0.0 Identities = 912/912 (100%), Positives = 912/912 (100%) Query: 1 MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR 60 MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR Sbjct: 1 MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR 60 Query: 61 GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL 120 GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL Sbjct: 61 GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL 120 Query: 121 TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA 180 TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA Sbjct: 121 TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA 180 Query: 181 STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ 240 STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ Sbjct: 181 STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ 240 Query: 241 KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA 300 KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA Sbjct: 241 KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA 300 Query: 301 NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI 360 NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI Sbjct: 301 NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI 360 Query: 361 WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL 420 WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL Sbjct: 361 WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL 420 Query: 421 HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY 480 HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY Sbjct: 421 HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY 480 Query: 481 QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW 540 QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW Sbjct: 481 QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW 540 Query: 541 HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA 600 HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA Sbjct: 541 HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA 600 Query: 601 ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG 660 ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG Sbjct: 601 ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG 660 Query: 661 LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV 720 LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV Sbjct: 661 LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV 720 Query: 721 DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET 780 DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET Sbjct: 721 DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET 780 Query: 781 FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP 840 FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP Sbjct: 781 FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP 840 Query: 841 KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT 900 KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT Sbjct: 841 KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT 900 Query: 901 KQTYVTYTNHAI 912 KQTYVTYTNHAI Sbjct: 901 KQTYVTYTNHAI 912 >gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor [Homo sapiens] Length = 908 Score = 1411 bits (3653), Expect = 0.0 Identities = 679/901 (75%), Positives = 774/901 (85%), Gaps = 1/901 (0%) Query: 12 ARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELK 71 A P LL+ W+ + + + + +SIR+DGDI LGGLFPVH +G G PCGELK Sbjct: 9 ASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK 68 Query: 72 KEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDG 131 KEKGIHRLEAML+A+D+IN DPDLL NITLG RILDTCSRDT+ALEQSLTFVQALIEKD Sbjct: 69 KEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDA 128 Query: 132 TEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSR 191 ++V+C +G PPI TKP+++ GVIGA+ SSVSIMVANILRLFKIPQISYASTAP+LSDN+R Sbjct: 129 SDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 Query: 192 YDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIA 251 YDFFSRVVP D+YQAQAMVDIV AL WNYVST+ASEG+YGESGVEAF Q SRE GGVCIA Sbjct: 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIA 248 Query: 252 QSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGS 311 QS KIPREP+ GEF+KII+RLLET NARAVI+FANEDDIRR+LEAA++ NQ+GHF W+GS Sbjct: 249 QSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 Query: 312 DSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFH 371 DSWGSKIAPV EE+AEGAVTILPKR S+ GFDRYF SRTL NNRRN+WFAEFWE+NF Sbjct: 309 DSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFG 368 Query: 372 CKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGR 431 CKL H K+ SH+KKCT ERI +DS+YEQEGKVQFVIDAVY+M +ALH MH+DLCPG Sbjct: 369 CKLGSHG-KRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY 427 Query: 432 VGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKV 491 +GLCPRM +DG +LL YIR VNF+G AG PVTFNENGDAPGRYDI+QYQ+ N S EYKV Sbjct: 428 IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKV 487 Query: 492 IGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQ 551 IG WT+ LHL++E M W P S+CSLPC+PGERKKTVKG+PCCWHCE C GY YQ Sbjct: 488 IGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQ 547 Query: 552 VDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVR 611 VD +C+ CP D RP NRTGC+ IPIIKLEW SPWAV+P+F+A++GI AT FV++TFVR Sbjct: 548 VDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVR 607 Query: 612 YNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALL 671 YNDTPIV+ASGRELSYVLL GIFLCY+ TFLMIA PD CS RR+FLGLGM SYAALL Sbjct: 608 YNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALL 667 Query: 672 TKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQD 731 TKTNRI+RIFEQGK+SV+AP+FISPASQL ITFSLIS+QLLG+ VWFVVDP H ++D+ + Sbjct: 668 TKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGE 727 Query: 732 QRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTM 791 QRTLDP ARGVLKCDISDLSLIC LGYS+LLMVTCTVYAIKTRGVPETFNEAKPIGFTM Sbjct: 728 QRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTM 787 Query: 792 YTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQ 851 YTTCI+WLAFIPIFFGT+QSA+K+YIQTTTLTVS+SLSASVSLGMLYMPKVYII+FHPEQ Sbjct: 788 YTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQ 847 Query: 852 NVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHA 911 NV KRKRS KAVVTAATM +K QKGN RPNGE KSELCE+LE +TK TY++Y+NH+ Sbjct: 848 NVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHS 907 Query: 912 I 912 I Sbjct: 908 I 908 >gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor [Homo sapiens] Length = 908 Score = 1392 bits (3604), Expect = 0.0 Identities = 671/883 (75%), Positives = 761/883 (86%), Gaps = 1/883 (0%) Query: 12 ARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELK 71 A P LL+ W+ + + + + +SIR+DGDI LGGLFPVH +G G PCGELK Sbjct: 9 ASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK 68 Query: 72 KEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDG 131 KEKGIHRLEAML+A+D+IN DPDLL NITLG RILDTCSRDT+ALEQSLTFVQALIEKD Sbjct: 69 KEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDA 128 Query: 132 TEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSR 191 ++V+C +G PPI TKP+++ GVIGA+ SSVSIMVANILRLFKIPQISYASTAP+LSDN+R Sbjct: 129 SDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 Query: 192 YDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIA 251 YDFFSRVVP D+YQAQAMVDIV AL WNYVST+ASEG+YGESGVEAF Q SRE GGVCIA Sbjct: 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIA 248 Query: 252 QSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGS 311 QS KIPREP+ GEF+KII+RLLET NARAVI+FANEDDIRR+LEAA++ NQ+GHF W+GS Sbjct: 249 QSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 Query: 312 DSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFH 371 DSWGSKIAPV EE+AEGAVTILPKR S+ GFDRYF SRTL NNRRN+WFAEFWE+NF Sbjct: 309 DSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFG 368 Query: 372 CKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGR 431 CKL H K+ SH+KKCT ERI +DS+YEQEGKVQFVIDAVY+M +ALH MH+DLCPG Sbjct: 369 CKLGSHG-KRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY 427 Query: 432 VGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKV 491 +GLCPRM +DG +LL YIR VNF+G AG PVTFNENGDAPGRYDI+QYQ+ N S EYKV Sbjct: 428 IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKV 487 Query: 492 IGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQ 551 IG WT+ LHL++E M W P S+CSLPC+PGERKKTVKG+PCCWHCE C GY YQ Sbjct: 488 IGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQ 547 Query: 552 VDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVR 611 VD +C+ CP D RP NRTGC+ IPIIKLEW SPWAV+P+F+A++GI AT FV++TFVR Sbjct: 548 VDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVR 607 Query: 612 YNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALL 671 YNDTPIV+ASGRELSYVLL GIFLCY+ TFLMIA PD CS RR+FLGLGM SYAALL Sbjct: 608 YNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALL 667 Query: 672 TKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQD 731 TKTNRI+RIFEQGK+SV+AP+FISPASQL ITFSLIS+QLLG+ VWFVVDP H ++D+ + Sbjct: 668 TKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGE 727 Query: 732 QRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTM 791 QRTLDP ARGVLKCDISDLSLIC LGYS+LLMVTCTVYAIKTRGVPETFNEAKPIGFTM Sbjct: 728 QRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTM 787 Query: 792 YTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQ 851 YTTCI+WLAFIPIFFGT+QSA+K+YIQTTTLTVS+SLSASVSLGMLYMPKVYII+FHPEQ Sbjct: 788 YTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQ 847 Query: 852 NVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLE 894 NV KRKRS KAVVTAATM +K QKGN RPNGE KSELCE+LE Sbjct: 848 NVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLE 890 >gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor [Homo sapiens] Length = 915 Score = 1316 bits (3406), Expect = 0.0 Identities = 633/903 (70%), Positives = 761/903 (84%), Gaps = 5/903 (0%) Query: 13 RLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKK 72 + P C+L L ++ G+ PH SIRI+GD+TLGGLFPVH +G G PCG++K+ Sbjct: 15 KFPCCVLEVLLCALAAAARGQEMYAPH--SIRIEGDVTLGGLFPVHAKGPSGVPCGDIKR 72 Query: 73 EKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGT 132 E GIHRLEAML+ALD+IN+DP+LLPN+TLGARILDTCSRDT+ALEQSLTFVQALI+KD + Sbjct: 73 ENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTS 132 Query: 133 EVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRY 192 +VRC +G PP+ KPE+VVGVIGASGSSVSIMVANILRLF+IPQISYASTAP+LSD+ RY Sbjct: 133 DVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRY 192 Query: 193 DFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQ 252 DFFSRVVP D++QAQAMVDIV+AL WNYVST+ASEGSYGE GVE+F Q S+E GG+CIAQ Sbjct: 193 DFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQ 252 Query: 253 SVKIPREPKAG--EFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMG 310 SV+IP+E K +FD+II++LL+T N+RAV+IFAN++DI+++L AA+RA+Q GHF W+G Sbjct: 253 SVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVG 312 Query: 311 SDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNF 370 SDSWGSKI P+ E++AEGA+TI PKR +V GFD YF+SRTL+NNRRN+WFAE+WE+NF Sbjct: 313 SDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENF 372 Query: 371 HCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPG 430 +CKL+ KK +KCT +ERIG+DS YEQEGKVQFVIDAVYAM HALH M++DLC Sbjct: 373 NCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCAD 432 Query: 431 RVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAE-Y 489 G+CP M+ G +LLKYIRNVNF+G AG PV FN+NGDAPGRYDI+QYQ N S Y Sbjct: 433 YRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGY 492 Query: 490 KVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQ 549 ++IG WTD L L IE M W +++P S+C+LPC+PG+RKKT KG PCCW CEPC GYQ Sbjct: 493 RLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQ 552 Query: 550 YQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITF 609 YQ D TC+ CPYD RP ENRTGC+ IPIIKLEW SPWAV+P+FLA++GI AT+FV+ TF Sbjct: 553 YQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATF 612 Query: 610 VRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAA 669 +RYNDTPIV+ASGRELSYVLL GIFLCY TFLMIA+PD+ CS RR+FLGLGM ISYAA Sbjct: 613 IRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAA 672 Query: 670 LLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDF 729 LLTKTNRIYRIFEQGK+SV+APR ISP SQLAIT SLIS+QLLG+ +WF VDP + ++D+ Sbjct: 673 LLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDY 732 Query: 730 QDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGF 789 + +T++P ARGVLKCDI+DL +IC LGYS+LLMVTCTVYAIKTRGVPE FNEAKPIGF Sbjct: 733 DEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGF 792 Query: 790 TMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHP 849 TMYTTCIVWLAFIPIFFGT+QSA+KLYIQTTTLT+S++LSASV+LGMLYMPKVYII+FHP Sbjct: 793 TMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHP 852 Query: 850 EQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTN 909 E NV KRKRS KAVVTAATMS++ + K + RPNGEAK+ELCEN++ + A K+ YV+Y N Sbjct: 853 ELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNN 912 Query: 910 HAI 912 I Sbjct: 913 LVI 915 >gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor [Homo sapiens] Length = 922 Score = 1305 bits (3376), Expect = 0.0 Identities = 626/885 (70%), Positives = 751/885 (84%), Gaps = 5/885 (0%) Query: 13 RLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKK 72 + P C+L L ++ G+ PH SIRI+GD+TLGGLFPVH +G G PCG++K+ Sbjct: 15 KFPCCVLEVLLCALAAAARGQEMYAPH--SIRIEGDVTLGGLFPVHAKGPSGVPCGDIKR 72 Query: 73 EKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGT 132 E GIHRLEAML+ALD+IN+DP+LLPN+TLGARILDTCSRDT+ALEQSLTFVQALI+KD + Sbjct: 73 ENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTS 132 Query: 133 EVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRY 192 +VRC +G PP+ KPE+VVGVIGASGSSVSIMVANILRLF+IPQISYASTAP+LSD+ RY Sbjct: 133 DVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRY 192 Query: 193 DFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQ 252 DFFSRVVP D++QAQAMVDIV+AL WNYVST+ASEGSYGE GVE+F Q S+E GG+CIAQ Sbjct: 193 DFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQ 252 Query: 253 SVKIPREPKAG--EFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMG 310 SV+IP+E K +FD+II++LL+T N+RAV+IFAN++DI+++L AA+RA+Q GHF W+G Sbjct: 253 SVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVG 312 Query: 311 SDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNF 370 SDSWGSKI P+ E++AEGA+TI PKR +V GFD YF+SRTL+NNRRN+WFAE+WE+NF Sbjct: 313 SDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENF 372 Query: 371 HCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPG 430 +CKL+ KK +KCT +ERIG+DS YEQEGKVQFVIDAVYAM HALH M++DLC Sbjct: 373 NCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCAD 432 Query: 431 RVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAE-Y 489 G+CP M+ G +LLKYIRNVNF+G AG PV FN+NGDAPGRYDI+QYQ N S Y Sbjct: 433 YRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGY 492 Query: 490 KVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQ 549 ++IG WTD L L IE M W +++P S+C+LPC+PG+RKKT KG PCCW CEPC GYQ Sbjct: 493 RLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQ 552 Query: 550 YQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITF 609 YQ D TC+ CPYD RP ENRTGC+ IPIIKLEW SPWAV+P+FLA++GI AT+FV+ TF Sbjct: 553 YQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATF 612 Query: 610 VRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAA 669 +RYNDTPIV+ASGRELSYVLL GIFLCY TFLMIA+PD+ CS RR+FLGLGM ISYAA Sbjct: 613 IRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAA 672 Query: 670 LLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDF 729 LLTKTNRIYRIFEQGK+SV+APR ISP SQLAIT SLIS+QLLG+ +WF VDP + ++D+ Sbjct: 673 LLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDY 732 Query: 730 QDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGF 789 + +T++P ARGVLKCDI+DL +IC LGYS+LLMVTCTVYAIKTRGVPE FNEAKPIGF Sbjct: 733 DEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGF 792 Query: 790 TMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHP 849 TMYTTCIVWLAFIPIFFGT+QSA+KLYIQTTTLT+S++LSASV+LGMLYMPKVYII+FHP Sbjct: 793 TMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHP 852 Query: 850 EQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLE 894 E NV KRKRS KAVVTAATMS++ + K + RPNGEAK+ELCEN++ Sbjct: 853 ELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVD 897 >gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo sapiens] Length = 877 Score = 1248 bits (3229), Expect = 0.0 Identities = 606/864 (70%), Positives = 708/864 (81%), Gaps = 13/864 (1%) Query: 12 ARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELK 71 AR PL + L + L + G S+R+ G +TLGGLFPVH RG+ G+ CG+LK Sbjct: 7 AREPLLVALLPLAWLAQAGLARAAG-----SVRLAGGLTLGGLFPVHARGAAGRACGQLK 61 Query: 72 KEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEK-- 129 KE+G+HRLEAML+ALDR+N DP+LLP + LGAR+LDTCSRDT+ALEQ+L+FVQALI Sbjct: 62 KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRG 121 Query: 130 DGTEV--RCGSGGPPII-TKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDL 186 DG EV RC G PP+ PERVV V+GAS SSVSIMVAN+LRLF IPQISYASTAP+L Sbjct: 122 DGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPEL 181 Query: 187 SDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDG 246 SD++RYDFFSRVVP D+YQAQAMVDIVRAL WNYVST+ASEG+YGESGVEAF+Q SRE G Sbjct: 182 SDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAG 241 Query: 247 GVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHF 306 GVCIAQS+KIPREPK GEF K+IRRL+ET NAR +IIFANEDDIRRVLEAAR+AN TGHF Sbjct: 242 GVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHF 301 Query: 307 FWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFW 366 W+GSDSWG+K +P+L LE+VA GA+TILPKR S+ GFD+YF +R+L+NNRRNIWFAEFW Sbjct: 302 LWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFW 361 Query: 367 EDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRD 426 E+NF+CKL+ + +KCT ERIG+DS YEQEGKVQFVIDAVYA+ HALH+MH+ Sbjct: 362 EENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQA 421 Query: 427 LCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDS 486 LCPG GLCP M+P DG LL+YIR V F+G AG PV FNENGDAPGRYDI+QYQ N S Sbjct: 422 LCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGS 481 Query: 487 AE---YKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCE 543 A Y+ +G W + L L +E + W G ++P S+CSLPC PGERKK VKG+PCCWHCE Sbjct: 482 ASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCE 541 Query: 544 PCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATL 603 C GY++QVD +TC+ CP DMRPT N TGCRP P+++L W SPWA PL LAV+GI AT Sbjct: 542 ACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATT 601 Query: 604 FVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGM 663 VV TFVRYN+TPIV+ASGRELSYVLL GIFL YA TFLM+AEP C+ RR+FLGLG Sbjct: 602 TVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGT 661 Query: 664 SISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPS 723 ++SY+ALLTKTNRIYRIFEQGKRSV+ P FISP SQL ITFSL SLQ++G+ W P Sbjct: 662 TLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPP 721 Query: 724 HSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNE 783 HSV+D+++QRT+DP ARGVLKCD+SDLSLI LGYS+LLMVTCTVYAIK RGVPETFNE Sbjct: 722 HSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNE 781 Query: 784 AKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVY 843 AKPIGFTMYTTCI+WLAF+PIFFGT+QSA+K+YIQTTTLTVS+SLSASVSLGMLY+PK Y Sbjct: 782 AKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTY 841 Query: 844 IILFHPEQNVPKRKRSLKAVVTAA 867 +ILFHPEQNV KRKRSLKA T A Sbjct: 842 VILFHPEQNVQKRKRSLKATSTVA 865 >gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo sapiens] Length = 879 Score = 731 bits (1888), Expect = 0.0 Identities = 398/861 (46%), Positives = 527/861 (61%), Gaps = 31/861 (3%) Query: 18 LLLSLYGPWMPSSLGKPKGHPHMN-SIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGI 76 L L+L+ SLG H + I+I+GD+ LGGLFP++ +G+ + CG + +++GI Sbjct: 10 LTLALFSKGFLLSLGD---HNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGI 66 Query: 77 HRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEK-DGTEVR 135 RLEAMLFA+D IN D LLP + LG ILDTCSRDT+ALEQSL FV+A + K D E Sbjct: 67 QRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYM 126 Query: 136 CGSGGPPIITK-PERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDF 194 C G I P + GVIG S SSVSI VAN+LRLF+IPQISYAST+ LSD SRYD+ Sbjct: 127 CPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 186 Query: 195 FSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSV 254 F+R VP D YQA+AM +I+R W YVSTVASEG YGE+G+EAF Q++R +CIA + Sbjct: 187 FARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRN-ICIATAE 245 Query: 255 KIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSW 314 K+ R +D +IR LL+ NAR V++F DD R ++ AA RAN + F W+ SD W Sbjct: 246 KVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANAS--FTWVASDGW 303 Query: 315 GSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKL 374 G++ + + E VA GA+T+ VR FDRYF S NN RN WF +FWE F C L Sbjct: 304 GAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL 363 Query: 375 SRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGL 434 K +H + C I S YEQE K+ FV++AVYAM HALH M R LCP L Sbjct: 364 QN----KRNHRRVCDKHLAI-DSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKL 418 Query: 435 CPRMDPVDGTQLLK-YIRNVNFSGI------AGNPVTFNENGDAPGRYDIYQYQLRNDSA 487 C M +DG +L K Y+ +NF+ A + V F+ GD GRY+++ +Q Sbjct: 419 CDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKY 478 Query: 488 EYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTG 547 Y +G W + L L + +HW S +P S CS PC P E K G CCW C PC Sbjct: 479 SYLKVGHWAETLSLDVNSIHW--SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEP 536 Query: 548 YQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVI 607 Y+Y D +TC C PT + TGC +P + W WA+ P+ +A +G T VV Sbjct: 537 YEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVT 596 Query: 608 TFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISY 667 F+++N+TP+VKASGREL Y+LL G+ L Y TF IA+P C+LRR+ LG +I Y Sbjct: 597 VFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICY 656 Query: 668 AALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVV 727 +ALLTKTN I RIF+ K P+FISP+SQ+ I LI +Q++ + VW +++ + Sbjct: 657 SALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGT-- 714 Query: 728 DFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPI 787 + TL + +LKC++ D S++ L Y ++L++ CTVYA KTR PE FNEAK I Sbjct: 715 ---RRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFI 771 Query: 788 GFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILF 847 GFTMYTTCI+WLAF+PIF+ TS +QTTT+ +SVSLS V LG L+ PKV+IILF Sbjct: 772 GFTMYTTCIIWLAFLPIFYVTSSD---YRVQTTTMCISVSLSGFVVLGCLFAPKVHIILF 828 Query: 848 HPEQNVPKRKRSLKAVVTAAT 868 P++NV + L + T Sbjct: 829 QPQKNVVTHRLHLNRFSVSGT 849 >gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor [Homo sapiens] Length = 872 Score = 726 bits (1874), Expect = 0.0 Identities = 397/853 (46%), Positives = 518/853 (60%), Gaps = 35/853 (4%) Query: 38 PHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLP 97 P + ++GD+ LGGLFPVH +G + CG + + +GI RLEAMLFALDRIN DP LLP Sbjct: 21 PAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLP 80 Query: 98 NITLGARILDTCSRDTHALEQSLTFVQALIEK--DGTEVRCGSGGPPII-TKPERVVGVI 154 + LGA ILD+CS+DTHALEQ+L FV+A + + DG+ C G P + GVI Sbjct: 81 GVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVI 140 Query: 155 GASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVR 214 G S S VSI VAN+LRLF+IPQISYAST+ LSD SRYD+F+R VP D +QA+AM +I+R Sbjct: 141 GGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILR 200 Query: 215 ALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE 274 W YVSTVASEG YGE+G+EAF ++R +C+A S K+ R F+ ++R LL+ Sbjct: 201 FFNWTYVSTVASEGDYGETGIEAFELEARARN-ICVATSEKVGRAMSRAAFEGVVRALLQ 259 Query: 275 TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTI 334 +AR ++F +D R +L A++R N + F W+ SD WG+ + V E AEGA+TI Sbjct: 260 KPSARVAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGAAEGAITI 317 Query: 335 LPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERI 394 + F YF S NN RN WF EFWE F C + +H + Sbjct: 318 ELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDC--AAHSLRAV----- 370 Query: 395 GQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLK-YIRNV 453 +EQE K+ FV++AVYAM HALH MHR LCP LC M PV+G +L K ++ NV Sbjct: 371 ----PFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNV 426 Query: 454 NFSGI-----AGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKV--IGSWTDHLHLRIERM 506 F N V F+ GD GRY+I+ Y LR S Y+ +G W + L L + Sbjct: 427 KFDAPFRPADTHNEVRFDRFGDGIGRYNIFTY-LRAGSGRYRYQKVGYWAEGLTLDTSLI 485 Query: 507 HWPG-SGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMR 565 W S LP S CS PC E K G CCW C PC Y+Y++D +TC C Sbjct: 486 PWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYW 545 Query: 566 PTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGREL 625 P + TGC +P + WG WAV P+ +A +G ATLFV+ FVR+N TP+VKASGREL Sbjct: 546 PNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGREL 605 Query: 626 SYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGK 685 Y+LL G+FLCY TF+ IA+P C+LRR+ LG S+ Y+ALLTKTNRI RIF + Sbjct: 606 CYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAR 665 Query: 686 RSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLK 745 PRFISPASQ+AI +LIS QLL + W VV+ + + T R L+ Sbjct: 666 EGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGT-----GKETAPERREVVTLR 720 Query: 746 CDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIF 805 C+ D S++ L Y++LL+ CT+YA KTR PE FNEAK IGFTMYTTCI+WLAF+PIF Sbjct: 721 CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF 780 Query: 806 FGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVT 865 + TS +QTTT+ VSVSLS SV LG L+ PK++IILF P++NV + + Sbjct: 781 YVTSSD---YRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGS 837 Query: 866 AATMSNKFTQKGN 878 AA ++ +G+ Sbjct: 838 AAARASSSLGQGS 850 >gi|166999223 glutamate receptor, metabotropic 1 isoform beta precursor [Homo sapiens] Length = 906 Score = 656 bits (1693), Expect = 0.0 Identities = 359/827 (43%), Positives = 505/827 (61%), Gaps = 37/827 (4%) Query: 44 RIDGDITLGGLFPVHGRGSEGK----PCGELKKEKGIHRLEAMLFALDRINNDPDLLPNI 99 R+DGD+ +G LF VH + K CGE++++ GI R+EAM LD+IN DP LLPNI Sbjct: 40 RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNI 99 Query: 100 TLGARILDTCSRDTHALEQSLTFVQALI-----EKDGTEVRC---GSGGPPIITKPERVV 151 TLG+ I D+C + ALEQS+ F++ + EKDG RC G PP TK + + Sbjct: 100 TLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGIN-RCLPDGQSLPPGRTK-KPIA 157 Query: 152 GVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVD 211 GVIG SSV+I V N+L+LF IPQI+Y++T+ DLSD + Y +F RVVPSDT QA+AM+D Sbjct: 158 GVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLD 217 Query: 212 IVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRR 271 IV+ W YVS V +EG+YGESG++AF + + ++G +CIA S KI FD+++R+ Sbjct: 218 IVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEG-LCIAHSDKIYSNAGEKSFDRLLRK 276 Query: 272 LLET-SNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEG 330 L E AR V+ F +R +L A RR G F +GSD W + + E A G Sbjct: 277 LRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANG 336 Query: 331 AVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTN 390 +TI + VR FD YF LD N RN WF EFW+ F C+L H L+ + + CT Sbjct: 337 GITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTG 396 Query: 391 RERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYI 450 E + ++ Y Q+ K+ FVI+A+YAM H L MH LCPG VGLC M P+DG++LL ++ Sbjct: 397 NESLEEN--YVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFL 454 Query: 451 RNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSA-EYKVIGSWTDHLHLRIERMHWP 509 +F G++G V F+E GDAPGRYDI Q + +Y +G+W + + L I+ Sbjct: 455 IKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQ 513 Query: 510 GSGQQLPRSICSLPCQPGERKKTVKG-MPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTE 568 + + RS+CS PC G+ K KG + CCW C C +Y D +TCK C P Sbjct: 514 MNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNA 573 Query: 569 NRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYV 628 + TGC PIP+ LEW + +++ + + +GI TLFV + FV Y DTP+VK+S REL Y+ Sbjct: 574 DLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYI 633 Query: 629 LLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSV 688 +LAGIFL Y F +IA+P +C L+R+ +GL ++ Y+AL+TKTNRI RI K+ + Sbjct: 634 ILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKI 693 Query: 689 SA--PRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKC 746 PRF+S +Q+ I LIS+QL + +++P ++ + P L C Sbjct: 694 CTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSY-------PSIKEVYLIC 746 Query: 747 DISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFF 806 + S+L ++ LGY+ LL+++CT YA KTR VP FNEAK I FTMYTTCI+WLAF+PI+F Sbjct: 747 NTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF 806 Query: 807 GTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNV 853 G++ + T +VSLS +V+LG ++ PK+YII+ PE+NV Sbjct: 807 GSN-------YKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846 >gi|166999098 glutamate receptor, metabotropic 1 isoform alpha precursor [Homo sapiens] Length = 1194 Score = 656 bits (1693), Expect = 0.0 Identities = 359/827 (43%), Positives = 505/827 (61%), Gaps = 37/827 (4%) Query: 44 RIDGDITLGGLFPVHGRGSEGK----PCGELKKEKGIHRLEAMLFALDRINNDPDLLPNI 99 R+DGD+ +G LF VH + K CGE++++ GI R+EAM LD+IN DP LLPNI Sbjct: 40 RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNI 99 Query: 100 TLGARILDTCSRDTHALEQSLTFVQALI-----EKDGTEVRC---GSGGPPIITKPERVV 151 TLG+ I D+C + ALEQS+ F++ + EKDG RC G PP TK + + Sbjct: 100 TLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGIN-RCLPDGQSLPPGRTK-KPIA 157 Query: 152 GVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVD 211 GVIG SSV+I V N+L+LF IPQI+Y++T+ DLSD + Y +F RVVPSDT QA+AM+D Sbjct: 158 GVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLD 217 Query: 212 IVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRR 271 IV+ W YVS V +EG+YGESG++AF + + ++G +CIA S KI FD+++R+ Sbjct: 218 IVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEG-LCIAHSDKIYSNAGEKSFDRLLRK 276 Query: 272 LLET-SNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEG 330 L E AR V+ F +R +L A RR G F +GSD W + + E A G Sbjct: 277 LRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANG 336 Query: 331 AVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTN 390 +TI + VR FD YF LD N RN WF EFW+ F C+L H L+ + + CT Sbjct: 337 GITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTG 396 Query: 391 RERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYI 450 E + ++ Y Q+ K+ FVI+A+YAM H L MH LCPG VGLC M P+DG++LL ++ Sbjct: 397 NESLEEN--YVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFL 454 Query: 451 RNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSA-EYKVIGSWTDHLHLRIERMHWP 509 +F G++G V F+E GDAPGRYDI Q + +Y +G+W + + L I+ Sbjct: 455 IKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQ 513 Query: 510 GSGQQLPRSICSLPCQPGERKKTVKG-MPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTE 568 + + RS+CS PC G+ K KG + CCW C C +Y D +TCK C P Sbjct: 514 MNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNA 573 Query: 569 NRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYV 628 + TGC PIP+ LEW + +++ + + +GI TLFV + FV Y DTP+VK+S REL Y+ Sbjct: 574 DLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYI 633 Query: 629 LLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSV 688 +LAGIFL Y F +IA+P +C L+R+ +GL ++ Y+AL+TKTNRI RI K+ + Sbjct: 634 ILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKI 693 Query: 689 SA--PRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKC 746 PRF+S +Q+ I LIS+QL + +++P ++ + P L C Sbjct: 694 CTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSY-------PSIKEVYLIC 746 Query: 747 DISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFF 806 + S+L ++ LGY+ LL+++CT YA KTR VP FNEAK I FTMYTTCI+WLAF+PI+F Sbjct: 747 NTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF 806 Query: 807 GTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNV 853 G++ + T +VSLS +V+LG ++ PK+YII+ PE+NV Sbjct: 807 GSN-------YKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846 >gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor [Homo sapiens] Length = 1212 Score = 655 bits (1691), Expect = 0.0 Identities = 355/819 (43%), Positives = 499/819 (60%), Gaps = 30/819 (3%) Query: 47 GDITLGGLFPVHGRGSEGK----PCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLG 102 GDI +G LF VH + + K CG ++++ GI R+EAML L+RIN+DP LLPNITLG Sbjct: 33 GDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLG 92 Query: 103 ARILDTCSRDTHALEQSLTFVQ-ALIEKDGTE--VRCGSGGPPIITKPERVVGVIGASGS 159 I D+C ALEQS+ F++ +LI + E VRC G + +VGVIG S Sbjct: 93 CEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSS 152 Query: 160 SVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWN 219 SV+I V N+L+LF IPQI+Y++T+ DLSD + + +F RVVPSD QA+AMVDIV+ W Sbjct: 153 SVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWT 212 Query: 220 YVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE-TSNA 278 YVS V +EG+YGESG+EAF S ++G +CIA S KI FDK++++L A Sbjct: 213 YVSAVHTEGNYGESGMEAFKDMSAKEG-ICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKA 271 Query: 279 RAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKR 338 R V F +R +L A RR G F +GSD W + + A G +TI + Sbjct: 272 RVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQS 331 Query: 339 MSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDS 398 V+ FD Y+ + N RN WF EFW+ F C+L + + K C + + + Sbjct: 332 PDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTL--KT 389 Query: 399 AYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGI 458 + Q+ K+ FVI+A+Y+M + LH M LCPG GLC M P+DG +LL+ + NF+G+ Sbjct: 390 HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGV 449 Query: 459 AGNPVTFNENGDAPGRYDIYQY-QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPR 517 +G+ + F+ENGD+PGRY+I + ++ D +Y +GSW D+ L+++ + R Sbjct: 450 SGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSW-DNGELKMDDDEVWSKKSNIIR 508 Query: 518 SICSLPCQPGERKKTVKG-MPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPI 576 S+CS PC+ G+ K KG + CCW C PC +Y D YTCK C PT++ TGC I Sbjct: 509 SVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLI 568 Query: 577 PIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLC 636 P+ L WG P + + A +G+ ATLFV + F+ Y DTP+VK+S REL Y++LAGI L Sbjct: 569 PVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLG 628 Query: 637 YATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSV--SAPRFI 694 Y TF +IA+P C L+RI +GL ++SY+AL+TKTNRI RI K+ + PRF+ Sbjct: 629 YLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFM 688 Query: 695 SPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLI 754 S +QL I F LI +QL I F+++P + D+ P L C+ ++L ++ Sbjct: 689 SACAQLVIAFILICIQLGIIVALFIMEPPDIMHDY-------PSIREVYLICNTTNLGVV 741 Query: 755 CLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK 814 LGY+ LL+++CT YA KTR VP FNEAK I FTMYTTCI+WLAF+PI+FG++ Sbjct: 742 TPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN----- 796 Query: 815 LYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNV 853 + T+ SVSLSA+V+LG +++PKVYIIL PE+NV Sbjct: 797 --YKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNV 833 >gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor [Homo sapiens] Length = 1180 Score = 655 bits (1691), Expect = 0.0 Identities = 355/819 (43%), Positives = 499/819 (60%), Gaps = 30/819 (3%) Query: 47 GDITLGGLFPVHGRGSEGK----PCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLG 102 GDI +G LF VH + + K CG ++++ GI R+EAML L+RIN+DP LLPNITLG Sbjct: 33 GDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLG 92 Query: 103 ARILDTCSRDTHALEQSLTFVQ-ALIEKDGTE--VRCGSGGPPIITKPERVVGVIGASGS 159 I D+C ALEQS+ F++ +LI + E VRC G + +VGVIG S Sbjct: 93 CEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSS 152 Query: 160 SVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWN 219 SV+I V N+L+LF IPQI+Y++T+ DLSD + + +F RVVPSD QA+AMVDIV+ W Sbjct: 153 SVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWT 212 Query: 220 YVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE-TSNA 278 YVS V +EG+YGESG+EAF S ++G +CIA S KI FDK++++L A Sbjct: 213 YVSAVHTEGNYGESGMEAFKDMSAKEG-ICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKA 271 Query: 279 RAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKR 338 R V F +R +L A RR G F +GSD W + + A G +TI + Sbjct: 272 RVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQS 331 Query: 339 MSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDS 398 V+ FD Y+ + N RN WF EFW+ F C+L + + K C + + + Sbjct: 332 PDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTL--KT 389 Query: 399 AYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGI 458 + Q+ K+ FVI+A+Y+M + LH M LCPG GLC M P+DG +LL+ + NF+G+ Sbjct: 390 HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGV 449 Query: 459 AGNPVTFNENGDAPGRYDIYQY-QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPR 517 +G+ + F+ENGD+PGRY+I + ++ D +Y +GSW D+ L+++ + R Sbjct: 450 SGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSW-DNGELKMDDDEVWSKKSNIIR 508 Query: 518 SICSLPCQPGERKKTVKG-MPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPI 576 S+CS PC+ G+ K KG + CCW C PC +Y D YTCK C PT++ TGC I Sbjct: 509 SVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLI 568 Query: 577 PIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLC 636 P+ L WG P + + A +G+ ATLFV + F+ Y DTP+VK+S REL Y++LAGI L Sbjct: 569 PVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLG 628 Query: 637 YATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSV--SAPRFI 694 Y TF +IA+P C L+RI +GL ++SY+AL+TKTNRI RI K+ + PRF+ Sbjct: 629 YLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFM 688 Query: 695 SPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLI 754 S +QL I F LI +QL I F+++P + D+ P L C+ ++L ++ Sbjct: 689 SACAQLVIAFILICIQLGIIVALFIMEPPDIMHDY-------PSIREVYLICNTTNLGVV 741 Query: 755 CLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK 814 LGY+ LL+++CT YA KTR VP FNEAK I FTMYTTCI+WLAF+PI+FG++ Sbjct: 742 TPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN----- 796 Query: 815 LYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNV 853 + T+ SVSLSA+V+LG +++PKVYIIL PE+NV Sbjct: 797 --YKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNV 833 >gi|37577159 calcium-sensing receptor [Homo sapiens] Length = 1078 Score = 409 bits (1050), Expect = e-114 Identities = 276/865 (31%), Positives = 437/865 (50%), Gaps = 74/865 (8%) Query: 47 GDITLGGLFPVH-GRGSEGKPCGELKKE--------KGIHRLEAMLFALDRINNDPDLLP 97 GDI LGGLFP+H G ++ + + +G L+AM+FA++ IN+ P LLP Sbjct: 30 GDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLP 89 Query: 98 NITLGARILDTCSRDTHALEQSLTFV-QALIEKDGTEVRCGSGGPPIITKPERVVGVIGA 156 N+TLG RI DTC+ + ALE +L+FV Q I+ + C T + V+GA Sbjct: 90 NLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPST-----IAVVGA 144 Query: 157 SGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRAL 216 +GS VS VAN+L LF IPQ+SYAS++ LS+ +++ F R +P+D +QA AM DI+ Sbjct: 145 TGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYF 204 Query: 217 KWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETS 276 +WN+V T+A++ YG G+E F +++ E+ +CI S I + E ++ +++ S Sbjct: 205 RWNWVGTIAADDDYGRPGIEKFREEA-EERDICIDFSELISQYSDEEEIQHVVE-VIQNS 262 Query: 277 NARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSK-IAPVLHLEEVAEGAVTIL 335 A+ +++F++ D+ +++ R N TG W+ S++W S + + V G + Sbjct: 263 TAKVIVVFSSGPDLEPLIKEIVRRNITGKI-WLASEAWASSSLIAMPQYFHVVGGTIGFA 321 Query: 336 PKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHAL-------------KKG 382 K + GF + + N + EFWE+ F+C L A + G Sbjct: 322 LKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESG 381 Query: 383 SHVKK--------CTNRERIGQ-DSAYEQEGKVQF---VIDAVYAMGHALHAMHRDLCPG 430 CT E I ++ Y ++ V AVY++ HAL ++ L PG Sbjct: 382 DRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCL-PG 440 Query: 431 RV----GLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQL--RN 484 R G C + V+ Q+LK++R++NF+ G VTF+E GD G Y I + L + Sbjct: 441 RGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPED 500 Query: 485 DSAEYKVIGSWT------DHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMP- 537 S +K +G + + L + E++ W G +++P S CS C G RK ++G P Sbjct: 501 GSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPT 560 Query: 538 CCWHCEPCTGYQY--QVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLA 595 CC+ C C +Y + D C CP D EN T C I L W P+ + A Sbjct: 561 CCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFA 620 Query: 596 VVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLR 655 V+GI T FV+ F+++ +TPIVKA+ RELSY+LL + C++++ I EP TC LR Sbjct: 621 VLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLR 680 Query: 656 RIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGIC 715 + G+ + + +L KTNR+ +FE + ++ Q + F +Q++ Sbjct: 681 QPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICV 740 Query: 716 VWFVVDPSHSVVDFQDQRTLDPRFARGVLKC-DISDLSLICLLGYSMLLMVTCTVYAIKT 774 +W P S +++Q D + C + S ++L L+GY+ LL C +A K+ Sbjct: 741 IWLYTAPPSS---YRNQELEDEII---FITCHEGSLMALGFLIGYTCLLAAICFFFAFKS 794 Query: 775 RGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVS- 833 R +PE FNEAK I F+M IVW++FIP + T + + V L+AS Sbjct: 795 RKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKF------VSAVEVIAILAASFGL 848 Query: 834 LGMLYMPKVYIILFHPEQNVPKRKR 858 L ++ K+YIILF P +N + R Sbjct: 849 LACIFFNKIYIILFKPSRNTIEEVR 873 >gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] Length = 841 Score = 245 bits (625), Expect = 2e-64 Identities = 228/845 (26%), Positives = 368/845 (43%), Gaps = 93/845 (11%) Query: 45 IDGDITLGGLFPVHGRGSEGKPCGELK--------KEKGIHRLEAMLFALDRINNDPDLL 96 + GD L GLFP+H + + E+ E G H +AM ++ INN LL Sbjct: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALL 93 Query: 97 PNITLGARILDTCS--RDTHALEQSLTFV-QALIEKDGTEVRCGSGGPPIITKPERVVGV 153 PNITLG ++ D CS + +A + L+ Q IE G ++ V+ V Sbjct: 94 PNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGD----------LLHYSPTVLAV 143 Query: 154 IGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIV 213 IG ++ + A +L F +P ISYA+++ LS +Y F R +P+D YQ + MV ++ Sbjct: 144 IGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLL 203 Query: 214 RALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAG-EFDKIIRRL 272 + W ++S V S YG+ GV+A ++ G+CIA +P + G E + + R Sbjct: 204 QKFGWTWISLVGSSDDYGQLGVQA-LENQATGQGICIAFKDIMPFSAQVGDERMQCLMRH 262 Query: 273 LETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSK--IAPVLHLEEVAEG 330 L + A V++F++ R E+ N TG W+ S++W I V ++ + Sbjct: 263 LAQAGATVVVVFSSRQLARVFFESVVLTNLTGKV-WVASEAWALSRHITGVPGIQRIGMV 321 Query: 331 AVTILPKRM--SVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCK----LSRHALKKGSH 384 + KR ++ F+ ++ R R + N C+ H + K Sbjct: 322 LGVAIQKRAVPGLKAFEEAYA-RADKKAPRPCHKGSWCSSNQLCRECQAFMAHTMPK--- 377 Query: 385 VKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGT 444 + SAY AVYA+ H LH L G C R V Sbjct: 378 ------LKAFSMSSAYN-------AYRAVYAVAHGLH----QLLGCASGACSR-GRVYPW 419 Query: 445 QLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGS--WTD-HLHL 501 QLL+ I V+F + + V FN+N D Y+I + + V+GS W+ L++ Sbjct: 420 QLLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNI 478 Query: 502 RIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTG--YQYQVDRYTCKT 559 ++ W G Q+P+S+CS C G ++ CC+ C PC + + D Y C+ Sbjct: 479 NETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQP 538 Query: 560 CPYDMRPTENRTGC--RPIPIIKLEWGSPWAVLP----LFLAVVGIAATLFVVITFVRYN 613 C + E C R + + L + W +L L L ++G A F + Sbjct: 539 CGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAG------LFAWHL 592 Query: 614 DTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTK 673 DTP+V+++G L +++L + + + EP C LR+ LG +I + L + Sbjct: 593 DTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVR 652 Query: 674 TNRIYRIFEQGKRSVSAPRFISPASQL--AITFSLIS--LQLLGICVWFVVDPSHSVVDF 729 + ++ IF K S P F Q A F +IS QLL W VV ++ Sbjct: 653 SFQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREY 709 Query: 730 QDQRTLDPRFARGV-LKC-DISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPI 787 Q RF V L+C + + L I Y+ LL ++ + + +PE +NEAK + Sbjct: 710 Q-------RFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCV 762 Query: 788 GFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILF 847 F++ + W+A FF T+ D Y+ + +S S S G ++PK Y+IL Sbjct: 763 TFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLPKCYVILC 817 Query: 848 HPEQN 852 P+ N Sbjct: 818 RPDLN 822 >gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] Length = 839 Score = 241 bits (616), Expect = 2e-63 Identities = 223/851 (26%), Positives = 381/851 (44%), Gaps = 96/851 (11%) Query: 45 IDGDITLGGLFPVHGRGS--------EGKPCGELK-KEKGIHRLEAMLFALDRINNDPDL 95 + GD LGGLF +H + C E + K G + ++AM FA++ INND L Sbjct: 29 LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSL 88 Query: 96 LPNITLGARILDTC--SRDTHALEQSLTFVQAL--IEKDGTEVRCGSGGPPIITKPERVV 151 LP + LG I+D C S + + L L I++D + RVV Sbjct: 89 LPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYI------------SRVV 136 Query: 152 GVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVD 211 VIG S + VAN L LF +PQI+Y++ + +L D R+ R PS + +AMV Sbjct: 137 AVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQ 196 Query: 212 IVRALKWNYVSTVASEGSYGESGVEAFIQK-SREDGGVCIAQSVKIPR-EPKAGEFDKII 269 ++ +WN++ + S +YG + ++ +R D +CIA +P +P + Sbjct: 197 LMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRD--ICIAFQETLPTLQPNQNMTSEER 254 Query: 270 RRL------LETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLH 323 +RL L+ S AR V++F+ + + R N TG W+ S+SW I PVLH Sbjct: 255 QRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAV-WIASESWA--IDPVLH 311 Query: 324 -LEEVAEGA--VTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALK 380 L E+ + I + + + GF + ++ + N C +A Sbjct: 312 NLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATL 371 Query: 381 KGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAM---HRDLCPGRVGLCPR 437 + + + + ER+ V V AVYA+ HALH++ + C RV Sbjct: 372 SFNTILRLSG-ERV-----------VYSVYSAVYAVAHALHSLLGCDKSTCTKRV----- 414 Query: 438 MDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSW-- 495 V QLL+ I VNF+ + + + F+ GD +I Q+Q ++ + S+ Sbjct: 415 ---VYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYP 470 Query: 496 TDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPC---TGYQYQV 552 I+ + W +P S+CS CQ G++KK V CC+ C C T + Sbjct: 471 LQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTE 530 Query: 553 DRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRY 612 D Y C+ CP + ++ T C ++ LEW + LA +G +TL +++ F R+ Sbjct: 531 DEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRH 590 Query: 613 NDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLT 672 TPIV+++G + +++L + + Y + + P + TC R+ L +I + + Sbjct: 591 FQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAV 650 Query: 673 KTNRIYRIFEQGKRSVSA----PRFISPASQLA-ITFSLISLQLLGICVWFVVDPSHSVV 727 ++ +I F+ R A R+ P +A IT + + ++G+ + + + Sbjct: 651 RSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDP 710 Query: 728 DFQDQRTLDPRFARGVLKCDIS-DLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKP 786 D DP+ ++ C+ + SL+ +LL V +A + +P +NEAK Sbjct: 711 D-------DPKIT--IVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKF 761 Query: 787 IGFTM---YTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVY 843 I +M +T+ + F+ + G + + L V+V ++SLG + PK Y Sbjct: 762 ITLSMTFYFTSSVSLCTFMSAYSG-------VLVTIVDLLVTVLNLLAISLG-YFGPKCY 813 Query: 844 IILFHPEQNVP 854 +ILF+PE+N P Sbjct: 814 MILFYPERNTP 824 >gi|112807234 G protein-coupled receptor, family C, group 6, member A [Homo sapiens] Length = 926 Score = 239 bits (610), Expect = 9e-63 Identities = 222/846 (26%), Positives = 374/846 (44%), Gaps = 75/846 (8%) Query: 47 GDITLGGLFPVHGR--GSEGKP-------CGELKKEKGIHRLEAMLFALDRINNDPDLLP 97 G I +GGLF +H + SE P C + + L AM+ +++ INN LLP Sbjct: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTL-AMIHSIEMINNST-LLP 91 Query: 98 NITLGARILDTCSRDTHALEQSLTFVQAL-IEKDGTEVRCGSGGPPIITKPERVVGVIGA 156 + LG I DTC+ T A+ +L F+ ++ E +C + RV VIG+ Sbjct: 92 GVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYS-----SYMPRVKAVIGS 146 Query: 157 SGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRAL 216 S +++ V+ +L L +PQ+ Y STA LSD R+ F R VPSD +Q +AM +++ Sbjct: 147 GYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKS 206 Query: 217 KWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLET- 275 WN++ + ++ YG + FI ++ E VCIA +P + I R L+ Sbjct: 207 GWNWIGIITTDDDYGRLALNTFIIQA-EANNVCIAFKEVLPAFLSDNTIEVRINRTLKKI 265 Query: 276 ---SNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGS--KIAPVLHLEEVAEG 330 + +++F + + + A N W+ SD+W + KI + +++++ + Sbjct: 266 ILEAQVNVIVVFLRQFHVFDLFNKAIEMNINK--MWIASDNWSTATKITTIPNVKKIGK- 322 Query: 331 AVTILPKRMSVRGFDRYF---------SSRTLDNNRRNIWFAEFWEDN--FHCKLSRHAL 379 V +R ++ F + S + L ++ + +D C + Sbjct: 323 VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQR 382 Query: 380 KKGSHVKKCTNRERIGQDSA---YEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCP 436 K R + ++ Y + G + + AV+A+G+A+ RDLC R C Sbjct: 383 TLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAI----RDLCQARD--CQ 436 Query: 437 RMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSW- 495 + +LL ++NV F+ N F+ +GD YD+ ++ N + + Sbjct: 437 NPNAFQPWELLGVLKNVTFTD-GWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYD 495 Query: 496 --TDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMP-CCWHCEPCTGYQY-- 550 D + + + +S CS C PG+ KKT + CC+ C+ C Y Sbjct: 496 LQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTN 555 Query: 551 QVDRYTCKTCPYDMRPTENR-TGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITF 609 Q D C C R T C + L W A+L L L+++GI L V I F Sbjct: 556 QTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIF 615 Query: 610 VRYNDTPIVKASGR-ELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYA 668 R +TP+VK+SG + YV+L FL +A+T I EP TC R+ G+ ++ + Sbjct: 616 TRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCIS 675 Query: 669 ALLTKTNRIYRIFEQGKRSVSAPRFISPASQ-LAITFSLISLQLLGICVWFVVDPSHSVV 727 +LTK+ +I F + +F+ + + I F+ +Q++ +W + V Sbjct: 676 CILTKSLKILLAFSFDPK---LQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEV 732 Query: 728 DFQDQRTLDPRFARGVLKCDI-SDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKP 786 + R + +L+C+ S L+ +LGY +L C ++A K G E +NEAK Sbjct: 733 NVSLPRVI-------ILECEEGSILAFGTMLGYIAILAFICFIFAFK--GKYENYNEAKF 783 Query: 787 IGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIIL 846 I F M I W+ FIPI+ T Y+ + V + +S L ++PK Y+I+ Sbjct: 784 ITFGMLIYFIAWITFIPIYATTFGK----YVPAVEIIV-ILISNYGILYCTFIPKCYVII 838 Query: 847 FHPEQN 852 E N Sbjct: 839 CKQEIN 844 >gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] Length = 852 Score = 211 bits (536), Expect = 3e-54 Identities = 201/844 (23%), Positives = 352/844 (41%), Gaps = 76/844 (9%) Query: 43 IRIDGDITLGGLFPV--------HGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPD 94 +R+ GD LGGLFP+ R P G+ AM A++ INN D Sbjct: 29 LRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSD 88 Query: 95 LLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVI 154 LLP + LG + DTCS A++ SL F+ +D + P RV+ VI Sbjct: 89 LLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQP------RVLAVI 142 Query: 155 GASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVR 214 G S ++++ F +PQ+SY ++ LS + F R VPSD Q A ++++ Sbjct: 143 GPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQ 202 Query: 215 ALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQS--VKIPR--EPKAGEFDKIIR 270 WN+V+ + S+ YG G+ F + G +CIA V +PR + + G+ ++ Sbjct: 203 EFGWNWVAALGSDDEYGRQGLSIFSALAAARG-ICIAHEGLVPLPRADDSRLGKVQDVLH 261 Query: 271 RLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEG 330 ++ ++S + V++FA+ + + +++ W+ S++W + V+ L +A+ Sbjct: 262 QVNQSS-VQVVLLFASVHAAHALFNYSI-SSRLSPKVWVASEAWLTSDL-VMGLPGMAQM 318 Query: 331 AVTI--LPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRH--ALKKGSHVK 386 + L + + F +Y + A + F L L++ + Sbjct: 319 GTVLGFLQRGAQLHEFPQYVKTH----------LALATDPAFCSALGEREQGLEEDVVGQ 368 Query: 387 KCTNRERIGQD--SAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGT 444 +C + I SA + V AVY++ ALH + G CP DPV Sbjct: 369 RCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASG----CPAQDPVKPW 424 Query: 445 QLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIE 504 QLL+ + N+ F + G P+ F+ +G+ YD+ + + +G + L Sbjct: 425 QLLENMYNLTFH-VGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERL 483 Query: 505 RMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCT--GYQYQVDRYTCKTCPY 562 ++ W S Q P S CS CQ G+ ++ CC+ C C Y+ D C C Sbjct: 484 KIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQ 543 Query: 563 DMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASG 622 D E T C L WG P +L L L + + L + FV + D+P+V+ASG Sbjct: 544 DEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASG 603 Query: 623 RELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFE 682 L+ L + L + L +P C ++ L ++ L T + IF Sbjct: 604 GPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLT---GCLSTLFLQAAEIFV 660 Query: 683 QGKRSVSAPRFISPASQLAITFSLISLQLL---GICVWFVVD-PSHSVVDFQDQRTLDPR 738 + + +S +S + + ++ L +L +C W++V P V D+ T Sbjct: 661 ESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALV 720 Query: 739 FAR-------GVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTM 791 R G+ + L+ +C LG ++ R P +N A+ + F M Sbjct: 721 HCRTRSWVSFGLAHATNATLAFLCFLGTFLV------------RSQPGRYNRARGLTFAM 768 Query: 792 YTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQ 851 I W++F+P+ ++ ++ ++ L L ++P+ Y+++ P Sbjct: 769 LAYFITWVSFVPLLANV-----QVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGL 823 Query: 852 NVPK 855 N P+ Sbjct: 824 NTPE 827 >gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo sapiens] Length = 254 Score = 210 bits (534), Expect = 6e-54 Identities = 115/239 (48%), Positives = 152/239 (63%), Gaps = 8/239 (3%) Query: 640 TFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQ 699 TF+ IA+P C+LRR+ LG S+ Y+ALLTKTNRI RIF + PRFISPASQ Sbjct: 2 TFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQ 61 Query: 700 LAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGY 759 +AI +LIS QLL + W VV+ + + T R L+C+ D S++ L Y Sbjct: 62 VAICLALISGQLLIVVAWLVVEAPGT-----GKETAPERREVVTLRCNHRDASMLGSLAY 116 Query: 760 SMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQT 819 ++LL+ CT+YA KTR PE FNEAK IGFTMYTTCI+WLAF+PIF+ TS +QT Sbjct: 117 NVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSD---YRVQT 173 Query: 820 TTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGN 878 TT+ VSVSLS SV LG L+ PK++IILF P++NV + +AA ++ +G+ Sbjct: 174 TTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGS 232 >gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] Length = 587 Score = 135 bits (341), Expect = 1e-31 Identities = 115/424 (27%), Positives = 189/424 (44%), Gaps = 39/424 (9%) Query: 446 LLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGS--WTD-HLHLR 502 LL+ I V+F + + V FN+N D Y+I + + V+GS W+ L++ Sbjct: 167 LLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNIN 225 Query: 503 IERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTG--YQYQVDRYTCKTC 560 ++ W G Q+P+S+CS C G ++ CC+ C PC + + D Y C+ C Sbjct: 226 ETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPC 285 Query: 561 PYDMRPTENRTGC--RPIPIIKLEWGSPWAVLP----LFLAVVGIAATLFVVITFVRYND 614 + E C R + + L + W +L L L ++G A F + D Sbjct: 286 GKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAG------LFAWHLD 339 Query: 615 TPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKT 674 TP+V+++G L +++L + + + EP C LR+ LG +I + L ++ Sbjct: 340 TPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRS 399 Query: 675 NRIYRIFEQGKRSVSAPRFISPASQL--AITFSLIS--LQLLGICVWFVVDPSHSVVDFQ 730 ++ IF K S P F Q A F +IS QLL W VV ++Q Sbjct: 400 FQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQ 456 Query: 731 DQRTLDPRFARGV-LKC-DISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIG 788 RF V L+C + + L I Y+ LL ++ + + +PE +NEAK + Sbjct: 457 -------RFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVT 509 Query: 789 FTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFH 848 F++ + W+A FF T+ D Y+ + +S S S G ++PK Y+IL Sbjct: 510 FSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLPKCYVILCR 564 Query: 849 PEQN 852 P+ N Sbjct: 565 PDLN 568 Score = 51.6 bits (122), Expect = 3e-06 Identities = 42/144 (29%), Positives = 65/144 (45%), Gaps = 21/144 (14%) Query: 45 IDGDITLGGLFPVHGRGSEGKPCGELK--------KEKGIHRLEAMLFALDRINNDPDLL 96 + GD L GLFP+H + + E+ E G H +AM ++ INN LL Sbjct: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALL 93 Query: 97 PNITLGARILDTC--SRDTHALEQSLTFV-QALIEKDGTEVRCGSGGPPIITKPERVVGV 153 PNITLG ++ D C S + +A + L+ Q IE G ++ V+ V Sbjct: 94 PNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG----------DLLHYSPTVLAV 143 Query: 154 IGASGSSVSIMVANILRLFKIPQI 177 IG ++ + A +L F +P + Sbjct: 144 IGPDSTNRAATTAALLSPFLVPML 167 >gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] Length = 480 Score = 122 bits (306), Expect = 2e-27 Identities = 86/282 (30%), Positives = 138/282 (48%), Gaps = 24/282 (8%) Query: 45 IDGDITLGGLFPVHGRGSEGKPCGELK--------KEKGIHRLEAMLFALDRINNDPDLL 96 + GD L GLFP+H + + E+ E G H +AM ++ INN LL Sbjct: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALL 93 Query: 97 PNITLGARILDTCS--RDTHALEQSLTFV-QALIEKDGTEVRCGSGGPPIITKPERVVGV 153 PNITLG ++ D CS + +A + L+ Q IE G ++ V+ V Sbjct: 94 PNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGD----------LLHYSPTVLAV 143 Query: 154 IGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIV 213 IG ++ + A +L F +P ISYA+++ LS +Y F R +P+D YQ + MV ++ Sbjct: 144 IGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLL 203 Query: 214 RALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAG-EFDKIIRRL 272 + W ++S V S YG+ GV+A ++ G+CIA +P + G E + + R Sbjct: 204 QKFGWTWISLVGSSDDYGQLGVQA-LENQATGQGICIAFKDIMPFSAQVGDERMQCLMRH 262 Query: 273 LETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSW 314 L + A V++F++ R E+ N TG W+ S++W Sbjct: 263 LAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAW 303 >gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c precursor [Homo sapiens] Length = 899 Score = 65.1 bits (157), Expect = 3e-10 Identities = 43/198 (21%), Positives = 90/198 (45%), Gaps = 10/198 (5%) Query: 652 CSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQL 711 C R LGLG S+ Y ++ TK ++ +F + + + + P A L+ + + Sbjct: 601 CQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDV 660 Query: 712 LGICVWFVVDPSHSVVDF----QDQRTLDPRFARGVLKCDISDLS--LICLLGYSMLLMV 765 L + +W +VDP H ++ + + +D + C ++ L GY LL++ Sbjct: 661 LTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLL 720 Query: 766 TCTVYAIKTRGV-PETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTV 824 A +T+ V E N+ + +G +Y ++ L P+ S D + ++ Sbjct: 721 LGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF---AFASL 777 Query: 825 SVSLSASVSLGMLYMPKV 842 ++ S+ ++L +L++PK+ Sbjct: 778 AIVFSSYITLVVLFVPKM 795 Score = 52.0 bits (123), Expect = 3e-06 Identities = 63/295 (21%), Positives = 122/295 (41%), Gaps = 50/295 (16%) Query: 49 ITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDT 108 + +G LFP+ G G+ C A+ AL+ +N+ D+LP+ L +++ Sbjct: 108 VYIGALFPMSGGWPGGQACQP-----------AVEMALEDVNSRRDILPDYEL--KLIHH 154 Query: 109 CSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANI 168 S+ Q+ ++ L+ D P +++ + G S SVS +VA Sbjct: 155 DSKCDPG--QATKYLYELLYND----------------PIKIILMPGCS--SVSTLVAEA 194 Query: 169 LRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEG 228 R++ + +SY S++P LS+ R+ F R PS T V + W ++T+ Sbjct: 195 ARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTT 254 Query: 229 SYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANED 288 S ++ ++ +E G ++I + + L+ +AR ++ E Sbjct: 255 EVFTSTLDDLEERVKEAG-------IEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYET 307 Query: 289 DIRRVLEAARRANQTGH---FFWMG--SDSWGSKIAPVLH-----LEEVAEGAVT 333 + R+V + G +F +G +D+W P ++ + E EG +T Sbjct: 308 EARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHIT 362 >gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b precursor [Homo sapiens] Length = 844 Score = 65.1 bits (157), Expect = 3e-10 Identities = 43/198 (21%), Positives = 90/198 (45%), Gaps = 10/198 (5%) Query: 652 CSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQL 711 C R LGLG S+ Y ++ TK ++ +F + + + + P A L+ + + Sbjct: 546 CQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDV 605 Query: 712 LGICVWFVVDPSHSVVDF----QDQRTLDPRFARGVLKCDISDLS--LICLLGYSMLLMV 765 L + +W +VDP H ++ + + +D + C ++ L GY LL++ Sbjct: 606 LTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLL 665 Query: 766 TCTVYAIKTRGV-PETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTV 824 A +T+ V E N+ + +G +Y ++ L P+ S D + ++ Sbjct: 666 LGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF---AFASL 722 Query: 825 SVSLSASVSLGMLYMPKV 842 ++ S+ ++L +L++PK+ Sbjct: 723 AIVFSSYITLVVLFVPKM 740 Score = 56.2 bits (134), Expect = 1e-07 Identities = 76/343 (22%), Positives = 143/343 (41%), Gaps = 61/343 (17%) Query: 7 LGWWWARLPLCLLLS--LYGPWMPSSLGKPKGH----PHMNSIRIDGDITLGGLFPVHGR 60 +GW LPL ++++ + W S P+ H PH +S R + +G LFP+ G Sbjct: 10 VGW---PLPLLVVMAAGVAPVWASHSPHLPRPHSRVPPHPSSER--RAVYIGALFPMSGG 64 Query: 61 GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL 120 G+ C A+ AL+ +N+ D+LP+ L +++ S+ Q+ Sbjct: 65 WPGGQACQP-----------AVEMALEDVNSRRDILPDYEL--KLIHHDSKCDPG--QAT 109 Query: 121 TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA 180 ++ L+ D P +++ + G S SVS +VA R++ + +SY Sbjct: 110 KYLYELLYND----------------PIKIILMPGCS--SVSTLVAEAARMWNLIVLSYG 151 Query: 181 STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ 240 S++P LS+ R+ F R PS T V + W ++T+ S ++ + Sbjct: 152 SSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEE 211 Query: 241 KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA 300 + +E G ++I + + L+ +AR ++ E + R+V + Sbjct: 212 RVKEAG-------IEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKE 264 Query: 301 NQTGH---FFWMG--SDSWGSKIAPVLH-----LEEVAEGAVT 333 G +F +G +D+W P ++ + E EG +T Sbjct: 265 RLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHIT 307 >gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a precursor [Homo sapiens] Length = 961 Score = 65.1 bits (157), Expect = 3e-10 Identities = 43/198 (21%), Positives = 90/198 (45%), Gaps = 10/198 (5%) Query: 652 CSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQL 711 C R LGLG S+ Y ++ TK ++ +F + + + + P A L+ + + Sbjct: 663 CQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDV 722 Query: 712 LGICVWFVVDPSHSVVDF----QDQRTLDPRFARGVLKCDISDLS--LICLLGYSMLLMV 765 L + +W +VDP H ++ + + +D + C ++ L GY LL++ Sbjct: 723 LTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLL 782 Query: 766 TCTVYAIKTRGV-PETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTV 824 A +T+ V E N+ + +G +Y ++ L P+ S D + ++ Sbjct: 783 LGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF---AFASL 839 Query: 825 SVSLSASVSLGMLYMPKV 842 ++ S+ ++L +L++PK+ Sbjct: 840 AIVFSSYITLVVLFVPKM 857 Score = 52.0 bits (123), Expect = 3e-06 Identities = 63/295 (21%), Positives = 122/295 (41%), Gaps = 50/295 (16%) Query: 49 ITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDT 108 + +G LFP+ G G+ C A+ AL+ +N+ D+LP+ L +++ Sbjct: 170 VYIGALFPMSGGWPGGQACQP-----------AVEMALEDVNSRRDILPDYEL--KLIHH 216 Query: 109 CSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANI 168 S+ Q+ ++ L+ D P +++ + G S SVS +VA Sbjct: 217 DSKCDPG--QATKYLYELLYND----------------PIKIILMPGCS--SVSTLVAEA 256 Query: 169 LRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEG 228 R++ + +SY S++P LS+ R+ F R PS T V + W ++T+ Sbjct: 257 ARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTT 316 Query: 229 SYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANED 288 S ++ ++ +E G ++I + + L+ +AR ++ E Sbjct: 317 EVFTSTLDDLEERVKEAG-------IEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYET 369 Query: 289 DIRRVLEAARRANQTGH---FFWMG--SDSWGSKIAPVLH-----LEEVAEGAVT 333 + R+V + G +F +G +D+W P ++ + E EG +T Sbjct: 370 EARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHIT 424 >gi|40255245 G protein-coupled receptor 51 [Homo sapiens] Length = 941 Score = 63.9 bits (154), Expect = 6e-10 Identities = 64/290 (22%), Positives = 136/290 (46%), Gaps = 31/290 (10%) Query: 590 LPLF-----LAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLM- 643 LPL+ L ++G+ + ++ + ++K S ++ +++ G L YA+ FL Sbjct: 479 LPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFG 538 Query: 644 -----IAEPDLGT-CSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPA 697 ++E T C++R L +G + ++ A+ KT R++ IF+ K + I Sbjct: 539 LDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQ 595 Query: 698 SQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFA------RGVLK-CDISD 750 L I ++ + L + W VDP V ++ +++P A R +L+ C+ + Sbjct: 596 KLLVIVGGMLLIDLCILICWQAVDPLRRTV---EKYSMEPDPAGRDISIRPLLEHCENTH 652 Query: 751 LS--LICLLGYSMLLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIVWLAFIPIFFG 807 ++ L + Y LLM+ A +TR V N++K IG ++Y I+ + + F Sbjct: 653 MTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFL 712 Query: 808 TSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRK 857 T D+ +Q + + + ++++L ++++PK+ + +P+ R+ Sbjct: 713 T---RDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRR 759 Score = 59.7 bits (143), Expect = 1e-08 Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 39/245 (15%) Query: 12 ARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELK 71 ARL L LLL L P P + G +G P +++ GL P+ ++G Sbjct: 21 ARLLLLLLLPLLLPLAPGAWGWARGAPRPPP--SSPPLSIMGLMPLTKEVAKG------- 71 Query: 72 KEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDG 131 G L A+ A+++I N+ L P L R+ DT + L+ F A+ Sbjct: 72 -SIGRGVLPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLK---AFYDAI----- 121 Query: 132 TEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSR 191 GP + V G SV+ ++A L+ + + Q+S+A+T P L+D + Sbjct: 122 ------KYGPNHLM-------VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKK 168 Query: 192 YDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIA 251 Y +F R VPSD A++ +++ +W V T+ + V+ F + + GV Sbjct: 169 YPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQD-------VQRFSEVRNDLTGVLYG 221 Query: 252 QSVKI 256 + ++I Sbjct: 222 EDIEI 226 >gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] Length = 324 Score = 57.4 bits (137), Expect = 6e-08 Identities = 31/103 (30%), Positives = 51/103 (49%), Gaps = 4/103 (3%) Query: 446 LLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGS--WTD-HLHLR 502 LL+ I V+F + + V FN+N D Y+I + + V+GS W+ L++ Sbjct: 167 LLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNIN 225 Query: 503 IERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPC 545 ++ W G Q+P+S+CS C G ++ CC+ C PC Sbjct: 226 ETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPC 268 Score = 51.6 bits (122), Expect = 3e-06 Identities = 42/144 (29%), Positives = 65/144 (45%), Gaps = 21/144 (14%) Query: 45 IDGDITLGGLFPVHGRGSEGKPCGELK--------KEKGIHRLEAMLFALDRINNDPDLL 96 + GD L GLFP+H + + E+ E G H +AM ++ INN LL Sbjct: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALL 93 Query: 97 PNITLGARILDTC--SRDTHALEQSLTFV-QALIEKDGTEVRCGSGGPPIITKPERVVGV 153 PNITLG ++ D C S + +A + L+ Q IE G ++ V+ V Sbjct: 94 PNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG----------DLLHYSPTVLAV 143 Query: 154 IGASGSSVSIMVANILRLFKIPQI 177 IG ++ + A +L F +P + Sbjct: 144 IGPDSTNRAATTAALLSPFLVPML 167 >gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] Length = 885 Score = 47.8 bits (112), Expect = 5e-05 Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 11/142 (7%) Query: 172 FKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVAS---EG 228 ++IP + + SD S + F R VP ++Q+ +++R WN++ + S EG Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173 Query: 229 SYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANED 288 + +E +++ RE + Q +P ++ E AR +I+ A+ED Sbjct: 174 RAAQKRLETLLEE-RESKAEKVLQF-----DPGTKNVTALLMEAKEL-EARVIILSASED 226 Query: 289 DIRRVLEAARRANQTGH-FFWM 309 D V AA N TG + W+ Sbjct: 227 DAATVYRAAAMLNMTGSGYVWL 248 >gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] Length = 938 Score = 47.8 bits (112), Expect = 5e-05 Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 11/142 (7%) Query: 172 FKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVAS---EG 228 ++IP + + SD S + F R VP ++Q+ +++R WN++ + S EG Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173 Query: 229 SYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANED 288 + +E +++ RE + Q +P ++ E AR +I+ A+ED Sbjct: 174 RAAQKRLETLLEE-RESKAEKVLQF-----DPGTKNVTALLMEAKEL-EARVIILSASED 226 Query: 289 DIRRVLEAARRANQTGH-FFWM 309 D V AA N TG + W+ Sbjct: 227 DAATVYRAAAMLNMTGSGYVWL 248 >gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] Length = 901 Score = 47.8 bits (112), Expect = 5e-05 Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 11/142 (7%) Query: 172 FKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVAS---EG 228 ++IP + + SD S + F R VP ++Q+ +++R WN++ + S EG Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173 Query: 229 SYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANED 288 + +E +++ RE + Q +P ++ E AR +I+ A+ED Sbjct: 174 RAAQKRLETLLEE-RESKAEKVLQF-----DPGTKNVTALLMEAKEL-EARVIILSASED 226 Query: 289 DIRRVLEAARRANQTGH-FFWM 309 D V AA N TG + W+ Sbjct: 227 DAATVYRAAAMLNMTGSGYVWL 248 >gi|7706451 G protein-coupled receptor, family C, group 5, member B precursor [Homo sapiens] Length = 403 Score = 46.6 bits (109), Expect = 1e-04 Identities = 55/272 (20%), Positives = 112/272 (41%), Gaps = 39/272 (14%) Query: 595 AVVGIAATLFVVITFVRYNDTPIVKASGRE----LSYVLLAGIFLCYATTFLMIAEPDLG 650 AV G A + +++ + P +K ++ L ++ L G + TF I + D Sbjct: 61 AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET 120 Query: 651 TCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPA--SQLAITFSLIS 708 CS+RR G+ ++ ++ LL++ R+ R+ G PA + + L+ Sbjct: 121 ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHG---------TGPAGWQLVGLALCLML 171 Query: 709 LQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCT 768 +Q++ W V + +D R C + + L Y M+L+V Sbjct: 172 VQVIIAVEWLV------LTVLRDTRP----------ACAYEPMDFVMALIYDMVLLVVTL 215 Query: 769 VYAIKTRGVPETFNEAKPIG----FTMYTTCIVWLAFIPIF-FGTSQSADKLYIQTTTLT 823 A+ T + F K G T + + ++W+A++ ++ FG + TL Sbjct: 216 GLALFT--LCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLA 273 Query: 824 VSVSLSASVSLGMLYMPKVYIILFHP-EQNVP 854 ++++ S V + +P+++ L ++N P Sbjct: 274 ITLAASGWVFVIFHAIPEIHCTLLPALQENTP 305 >gi|93204867 G protein-coupled receptor 158 [Homo sapiens] Length = 1215 Score = 44.7 bits (104), Expect = 4e-04 Identities = 63/268 (23%), Positives = 108/268 (40%), Gaps = 35/268 (13%) Query: 592 LFLAVVGIAATLFVVITFV------RYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIA 645 L LA++ A L +++ FV + ++ASG L +L G L Y ++ Sbjct: 416 LRLAIISFQA-LCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYF 474 Query: 646 EPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFS 705 EP C L R LG + Y + K +R+ ++F S +A R P Sbjct: 475 EPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVF----LSRTAQRI--PYMTGGRVMR 528 Query: 706 LISLQLLGICVWFVVDPSHSV-------VDFQDQRTLDPRFARGVLKCDISDLSLICLLG 758 ++++ LL + WF++ + SV + Q + D D + + Sbjct: 529 MLAVILL-VVFWFLIGWTSSVCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDY-MTAVAE 586 Query: 759 YSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK---- 814 + LL YA++T VP F+E + + ++ I+ F I F + Sbjct: 587 FLFLLWGVYLCYAVRT--VPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWML 644 Query: 815 -LYIQTTTLTVSVSLSASVSLGMLYMPK 841 LY T LTV +V++G+L +PK Sbjct: 645 MLYFAHTHLTV------TVTIGLLLIPK 666 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.323 0.138 0.430 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,888,153 Number of Sequences: 37866 Number of extensions: 1594277 Number of successful extensions: 3434 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 31 Number of HSP's successfully gapped in prelim test: 22 Number of HSP's that attempted gapping in prelim test: 3263 Number of HSP's gapped (non-prelim): 82 length of query: 912 length of database: 18,247,518 effective HSP length: 111 effective length of query: 801 effective length of database: 14,044,392 effective search space: 11249557992 effective search space used: 11249557992 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.