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Search of human proteins with 4502557
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
(473 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 938 0.0
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 278 1e-74
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 278 1e-74
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 276 4e-74
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 274 1e-73
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 274 1e-73
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 263 3e-70
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 250 2e-66
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 250 2e-66
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 249 4e-66
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 249 4e-66
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 249 4e-66
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 249 4e-66
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 243 2e-64
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 243 3e-64
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 242 6e-64
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 242 6e-64
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 241 8e-64
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 241 1e-63
gi|27901803 protein serine kinase H1 [Homo sapiens] 239 5e-63
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 238 7e-63
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 238 7e-63
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 238 9e-63
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 238 1e-62
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 236 3e-62
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 234 1e-61
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 234 2e-61
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 233 2e-61
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 233 2e-61
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 233 2e-61
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 938 bits (2424), Expect = 0.0
Identities = 473/473 (100%), Positives = 473/473 (100%)
Query: 1 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV 60
MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV
Sbjct: 1 MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV 60
Query: 61 YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL 120
YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL
Sbjct: 61 YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL 120
Query: 121 VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP 180
VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP
Sbjct: 121 VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP 180
Query: 181 LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP 240
LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP
Sbjct: 181 LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP 240
Query: 241 FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 300
FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV
Sbjct: 241 FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 300
Query: 301 TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS 360
TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS
Sbjct: 301 TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS 360
Query: 361 PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA 420
PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA
Sbjct: 361 PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA 420
Query: 421 VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY 473
VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
Sbjct: 421 VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY 473
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 278 bits (710), Expect = 1e-74
Identities = 149/332 (44%), Positives = 210/332 (63%), Gaps = 14/332 (4%)
Query: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRLSH 98
+S +E+ LG GA S V +++G+ ALK + K + +V EI VL R+SH
Sbjct: 28 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 87
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI+ L+++ E+P+ + L +ELVTGGELFDRI+E+G Y+E+DA+ V Q+L AV+YLH
Sbjct: 88 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 147
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218
GIVHRDLKPENLLYATP D+ + ++DFGLSKI +L T CGTPGY APE+L Y
Sbjct: 148 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNML-GTACGTPGYVAPELLEQKPY 206
Query: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278
G VD+W++G+I+YILLCG+ PFYDE D +F +IL Y F SP+WD++S +AKD +R
Sbjct: 207 GKAVDVWALGVISYILLCGYPPFYDE-SDPELFSQILRASYEFDSPFWDDISESAKDFIR 265
Query: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAAVKAVVASS 337
L+ DP+KR T QAL+H W++G A + + + +++++ AR K A A
Sbjct: 266 HLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLR 325
Query: 338 RL--------GSASSSHGSIQESHKASRDPSP 361
+ G +S G + SH R P
Sbjct: 326 HIRKLGQIPEGEGASEQGMARHSHSGLRAGQP 357
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 278 bits (710), Expect = 1e-74
Identities = 149/332 (44%), Positives = 210/332 (63%), Gaps = 14/332 (4%)
Query: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRLSH 98
+S +E+ LG GA S V +++G+ ALK + K + +V EI VL R+SH
Sbjct: 94 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 153
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI+ L+++ E+P+ + L +ELVTGGELFDRI+E+G Y+E+DA+ V Q+L AV+YLH
Sbjct: 154 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 213
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218
GIVHRDLKPENLLYATP D+ + ++DFGLSKI +L T CGTPGY APE+L Y
Sbjct: 214 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNML-GTACGTPGYVAPELLEQKPY 272
Query: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278
G VD+W++G+I+YILLCG+ PFYDE D +F +IL Y F SP+WD++S +AKD +R
Sbjct: 273 GKAVDVWALGVISYILLCGYPPFYDE-SDPELFSQILRASYEFDSPFWDDISESAKDFIR 331
Query: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAAVKAVVASS 337
L+ DP+KR T QAL+H W++G A + + + +++++ AR K A A
Sbjct: 332 HLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLR 391
Query: 338 RL--------GSASSSHGSIQESHKASRDPSP 361
+ G +S G + SH R P
Sbjct: 392 HIRKLGQIPEGEGASEQGMARHSHSGLRAGQP 423
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 276 bits (705), Expect = 4e-74
Identities = 147/323 (45%), Positives = 208/323 (64%), Gaps = 16/323 (4%)
Query: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALK-VLKKTVDKK--IVRTEIGVLLRLSH 98
+ D ++ LG GA S V + K TQK A+K + K+ ++ K + EI VL ++ H
Sbjct: 16 IRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKH 75
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI+ L +I+E+ + L+++LV+GGELFDRIVEKG+Y+ERDA+ + Q+L+AV YLH+
Sbjct: 76 PNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDL 135
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218
GIVHRDLKPENLLY + D+ + I+DFGLSK+ + ++ T CGTPGY APE+L Y
Sbjct: 136 GIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
Query: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278
VD WS+G+I YILLCG+ PFYDE D +F +IL EY F SP+WD++S +AKD +R
Sbjct: 196 SKAVDCWSIGVIAYILLCGYPPFYDE-NDAKLFEQILKAEYEFDSPYWDDISDSAKDFIR 254
Query: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA--NFVHMDTAQ---------KKLQEFNARRKLK 327
L+ DP+KR T QALQHPW+ G A +H ++ K Q FNA ++
Sbjct: 255 HLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVR 314
Query: 328 AAVKAVVASSRLGSA-SSSHGSI 349
K + +S+ G ++SHG +
Sbjct: 315 HMRKLQLGTSQEGQGQTASHGEL 337
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 274 bits (700), Expect = 1e-73
Identities = 148/321 (46%), Positives = 207/321 (64%), Gaps = 11/321 (3%)
Query: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDK---KIVRTEIGVLLRLSH 98
+ FE + LG GA S V ++K T K +A+K + K K + EI VL ++ H
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKH 78
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI+ L++I+E+P + LV++LV+GGELFDRIVEKG+Y+E+DA+ ++Q+L+AV YLH
Sbjct: 79 ENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRM 138
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218
GIVHRDLKPENLLY + ++ + I+DFGLSK+ +M T CGTPGY APE+L Y
Sbjct: 139 GIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY 198
Query: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278
VD WS+G+I YILLCG+ PFYDE D +F +IL EY F SP+WD++S +AKD +R
Sbjct: 199 SKAVDCWSIGVIAYILLCGYPPFYDE-NDSKLFEQILKAEYEFDSPYWDDISDSAKDFIR 257
Query: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAA--VKAVVA 335
L+ DP KR T QA +HPW+ G A N ++ ++++ A+ K + A AVV
Sbjct: 258 NLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVR 317
Query: 336 SSR---LGSA-SSSHGSIQES 352
R LGS+ SS+ S+ S
Sbjct: 318 HMRKLHLGSSLDSSNASVSSS 338
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 274 bits (700), Expect = 1e-73
Identities = 148/321 (46%), Positives = 207/321 (64%), Gaps = 11/321 (3%)
Query: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDK---KIVRTEIGVLLRLSH 98
+ FE + LG GA S V ++K T K +A+K + K K + EI VL ++ H
Sbjct: 19 IKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKH 78
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI+ L++I+E+P + LV++LV+GGELFDRIVEKG+Y+E+DA+ ++Q+L+AV YLH
Sbjct: 79 ENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRM 138
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218
GIVHRDLKPENLLY + ++ + I+DFGLSK+ +M T CGTPGY APE+L Y
Sbjct: 139 GIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY 198
Query: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278
VD WS+G+I YILLCG+ PFYDE D +F +IL EY F SP+WD++S +AKD +R
Sbjct: 199 SKAVDCWSIGVIAYILLCGYPPFYDE-NDSKLFEQILKAEYEFDSPYWDDISDSAKDFIR 257
Query: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAA--VKAVVA 335
L+ DP KR T QA +HPW+ G A N ++ ++++ A+ K + A AVV
Sbjct: 258 NLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVR 317
Query: 336 SSR---LGSA-SSSHGSIQES 352
R LGS+ SS+ S+ S
Sbjct: 318 HMRKLHLGSSLDSSNASVSSS 338
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 263 bits (672), Expect = 3e-70
Identities = 141/293 (48%), Positives = 194/293 (66%), Gaps = 12/293 (4%)
Query: 45 FFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT--VDKKIVRTEIGVLLRLSHPNII 102
F EV LG GA S V+ KQ+ T K +ALK +KK+ + EI VL ++ H NI+
Sbjct: 25 FMEV---LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIV 81
Query: 103 KLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVH 162
L++I+E+ T LV++LV+GGELFDRI+E+G Y+E+DA+ ++Q+L AV YLHENGIVH
Sbjct: 82 TLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVH 141
Query: 163 RDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEV 222
RDLKPENLLY TP ++ + I DFGLSK +E +M T CGTPGY APE+L Y V
Sbjct: 142 RDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPYSKAV 200
Query: 223 DMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIV 282
D WS+G+ITYILLCG+ PFY+E + +F +I Y F SP+WD++S +AKD + L+
Sbjct: 201 DCWSIGVITYILLCGYPPFYEET-ESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLE 259
Query: 283 LDPKKRLTTFQALQHPWVTGKAANFVHMD---TAQKKLQEFNARRKLKAAVKA 332
DP +R T +AL HPW+ G A +H D + ++Q+ A+ K + A A
Sbjct: 260 KDPNERYTCEKALSHPWIDGNTA--LHRDIYPSVSLQIQKNFAKSKWRQAFNA 310
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 250 bits (638), Expect = 2e-66
Identities = 150/380 (39%), Positives = 221/380 (58%), Gaps = 23/380 (6%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC + T + YA K++ D + + E + L H
Sbjct: 11 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILE+V + H N
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
GIVHRDLKPENLL A+ + A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VDMW+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AKDL
Sbjct: 191 YGKPVDMWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ K++ ++P KR+T +AL+HPW+ ++ A+ +H L++FNARRKLK A+ +
Sbjct: 249 INKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSASSSHGSIQESHKASRDPSPIQ--DGNEDMKAIPEGEKIQGDGAQAAVKGAQA 392
++R SA+ S + K + S +Q + E E E VK +
Sbjct: 309 LATRNFSAAKSLLKKPDGVKKRKSSSSVQMMESTESSNTTIEDED---------VKARKQ 359
Query: 393 ELMKV--QALEKVKGADINA 410
E++KV Q +E + D A
Sbjct: 360 EIIKVTEQLIEAINNGDFEA 379
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 250 bits (638), Expect = 2e-66
Identities = 148/383 (38%), Positives = 223/383 (58%), Gaps = 26/383 (6%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC + T + YA K++ D + + E + L H
Sbjct: 11 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILE+V + H N
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
GIVHRDLKPENLL A+ + A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VDMW+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AKDL
Sbjct: 191 YGKPVDMWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ K++ ++P KR+T +AL+HPW+ ++ A+ +H L++FNARRKLK A+ +
Sbjct: 249 INKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAA-----VKG 389
++R SA+ S + P +++ + P+G K + + VK
Sbjct: 309 LATRNFSAAKS---------LLKKPDGVKEPQTTVIHNPDGNKESTESSNTTIEDEDVKA 359
Query: 390 AQAELMKV--QALEKVKGADINA 410
+ E++KV Q +E + D A
Sbjct: 360 RKQEIIKVTEQLIEAINNGDFEA 382
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 249 bits (636), Expect = 4e-66
Identities = 142/337 (42%), Positives = 208/337 (61%), Gaps = 10/337 (2%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC + T + YA K++ D + + E + L H
Sbjct: 11 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILE+V + H N
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
GIVHRDLKPENLL A+ + A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VDMW+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AKDL
Sbjct: 191 YGKPVDMWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ K++ ++P KR+T +AL+HPW+ ++ A+ +H L++FNARRKLK A+ +
Sbjct: 249 INKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKA 371
++R SA+ S + K S + S +ED+KA
Sbjct: 309 LATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKA 345
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 249 bits (636), Expect = 4e-66
Identities = 142/337 (42%), Positives = 208/337 (61%), Gaps = 10/337 (2%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC + T + YA K++ D + + E + L H
Sbjct: 11 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILE+V + H N
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
GIVHRDLKPENLL A+ + A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VDMW+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AKDL
Sbjct: 191 YGKPVDMWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ K++ ++P KR+T +AL+HPW+ ++ A+ +H L++FNARRKLK A+ +
Sbjct: 249 INKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKA 371
++R SA+ S + K S + S +ED+KA
Sbjct: 309 LATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKA 345
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 249 bits (636), Expect = 4e-66
Identities = 142/337 (42%), Positives = 208/337 (61%), Gaps = 10/337 (2%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC + T + YA K++ D + + E + L H
Sbjct: 11 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILE+V + H N
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
GIVHRDLKPENLL A+ + A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VDMW+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AKDL
Sbjct: 191 YGKPVDMWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ K++ ++P KR+T +AL+HPW+ ++ A+ +H L++FNARRKLK A+ +
Sbjct: 249 INKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKA 371
++R SA+ S + K S + S +ED+KA
Sbjct: 309 LATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKA 345
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 249 bits (636), Expect = 4e-66
Identities = 142/337 (42%), Positives = 208/337 (61%), Gaps = 10/337 (2%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC + T + YA K++ D + + E + L H
Sbjct: 11 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILE+V + H N
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
GIVHRDLKPENLL A+ + A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VDMW+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AKDL
Sbjct: 191 YGKPVDMWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ K++ ++P KR+T +AL+HPW+ ++ A+ +H L++FNARRKLK A+ +
Sbjct: 249 INKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKA 371
++R SA+ S + K S + S +ED+KA
Sbjct: 309 LATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKA 345
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 243 bits (621), Expect = 2e-64
Identities = 145/386 (37%), Positives = 224/386 (58%), Gaps = 20/386 (5%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC +K + + YA K++ D + + E + L H
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ + QILE+V ++H++
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
IVHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T QAL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSAS------SSHGSI--QESHKASRDP--SPIQDGNEDMKAIPEGEKIQGDGAQ 384
SR SA+ S G + Q ++K S +P + + + + +K E +
Sbjct: 309 LVSRNFSAAKSLLNKKSDGGVKPQSNNKNSLEPQTTVVHNATDGIKGSTESCNTTTEDED 368
Query: 385 AAVKGAQAELMKVQALEKVKGADINA 410
V+ + + Q +E + D A
Sbjct: 369 LKVRKQEIIKITEQLIEAINNGDFEA 394
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 243 bits (620), Expect = 3e-64
Identities = 155/427 (36%), Positives = 238/427 (55%), Gaps = 34/427 (7%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC +K + + YA K++ D + + E + L H
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ + QILE+V ++H++
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
IVHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T QAL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSAS------SSHGSI--QESHKAS-----RDPSPIQDGNEDMKAIPEGEKIQGD 381
SR SA+ S G + Q ++K S ++P+P+Q E +
Sbjct: 309 LVSRNFSAAKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVH------- 361
Query: 382 GAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDGIKVADLELEEGLAEEKL 441
A +KG+ E +K + +E K+ + +E I D E + + L
Sbjct: 362 NATDGIKGSTESCNTTTEDEDLK---VRKQEIIKITEQLIE-AINNGDFEAYTKICDPGL 417
Query: 442 KTVEEAA 448
+ E A
Sbjct: 418 TSFEPEA 424
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 242 bits (617), Expect = 6e-64
Identities = 144/378 (38%), Positives = 216/378 (57%), Gaps = 24/378 (6%)
Query: 46 FEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSHPNI 101
+++ ELG+GA S+V RC + + YA K++ D + + E + L HPNI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 102 IKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIV 161
++L + L+ +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+ G+V
Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132
Query: 162 HRDLKPENLLYATPAPDAPLKIADFGLSKIVE-HQVLMKTVCGTPGYCAPEILRGCAYGP 220
HRDLKPENLL A+ A +K+ADFGL+ VE Q GTPGY +PE+LR YG
Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK 192
Query: 221 EVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDLVRK 279
VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AKDL+ K
Sbjct: 193 PVDLWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 250
Query: 280 LIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVVASS 337
++ ++P KR+T +AL+HPW++ ++ A+ +H L++FNARRKLK A+ + ++
Sbjct: 251 MLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLAT 310
Query: 338 RLGSASSSHGSIQESHKASRDPS---PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAEL 394
R S S G+ + R S + + +E E E K + E+
Sbjct: 311 RNFSGGKSGGNKKSDGVKKRKSSSSVQLMESSESTNTTIEDED---------TKVRKQEI 361
Query: 395 MKV--QALEKVKGADINA 410
+KV Q +E + D +
Sbjct: 362 IKVTEQLIEAISNGDFES 379
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 242 bits (617), Expect = 6e-64
Identities = 141/351 (40%), Positives = 213/351 (60%), Gaps = 23/351 (6%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC +K + + YA K++ D + + E + L H
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ + QILE+V ++H++
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
IVHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T QAL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSAS------SSHGSI--QESHKAS-----RDPSPIQDGNEDMKAI 372
SR SA+ S G + Q ++K S ++P+P+Q E +
Sbjct: 309 LVSRNFSAAKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTV 359
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 241 bits (616), Expect = 8e-64
Identities = 142/378 (37%), Positives = 222/378 (58%), Gaps = 13/378 (3%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC +K + + YA K++ D + + E + L H
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ + QILE+V ++H++
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
IVHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T QAL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSASSSHGSIQESHKASRDP--SPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQA 392
SR SA+ S + ++S ++P + + + + +K E + V+ +
Sbjct: 309 LVSRNFSAAKSLLN-KKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEI 367
Query: 393 ELMKVQALEKVKGADINA 410
+ Q +E + D A
Sbjct: 368 IKITEQLIEAINNGDFEA 385
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 241 bits (615), Expect = 1e-63
Identities = 137/334 (41%), Positives = 204/334 (61%), Gaps = 11/334 (3%)
Query: 46 FEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSHPNI 101
+++ ELG+GA S+V RC + + YA K++ D + + E + L HPNI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 102 IKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIV 161
++L + L+ +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+ G+V
Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132
Query: 162 HRDLKPENLLYATPAPDAPLKIADFGLSKIVE-HQVLMKTVCGTPGYCAPEILRGCAYGP 220
HRDLKPENLL A+ A +K+ADFGL+ VE Q GTPGY +PE+LR YG
Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK 192
Query: 221 EVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDLVRK 279
VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AKDL+ K
Sbjct: 193 PVDLWACGVILYILLVGYPPFWDE--DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 250
Query: 280 LIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVVASS 337
++ ++P KR+T +AL+HPW++ ++ A+ +H L++FNARRKLK A+ + ++
Sbjct: 251 MLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLAT 310
Query: 338 RLGSASSSHGSIQ-ESHKASRDPSPIQDGNEDMK 370
R S S G+ + + K S + + +ED K
Sbjct: 311 RNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTK 344
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 239 bits (609), Expect = 5e-63
Identities = 131/316 (41%), Positives = 194/316 (61%), Gaps = 12/316 (3%)
Query: 46 FEVESELGRGATSIVYRCKQKGTQKPYALKVL--KKTVDKKIVRTEIGVLLRLSHPNIIK 103
+++++ +GRG+ S V R + + T++PYA+K++ K +++ +E+ VL R+ H NII+
Sbjct: 98 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQ 157
Query: 104 LKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHR 163
L E+FET + +V+EL TGGELFDRI+ KG ++ERDA ++ +L+ V YLH GI HR
Sbjct: 158 LVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHR 217
Query: 164 DLKPENLLYATPAPDAPLKIADFGLSKIVE--HQVLMKTVCGTPGYCAPEILRGCAYGPE 221
DLKPENLLY P D+ + I DFGL+ + LMKT CGTP Y APE+L Y
Sbjct: 218 DLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNS 277
Query: 222 VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLI 281
VDMW++G+I YILL G PF D+ + ++R+IL +Y + W VS AKD + +L+
Sbjct: 278 VDMWALGVIAYILLSGTMPFEDDNRTR-LYRQILRGKYSYSGEPWPSVSNLAKDFIDRLL 336
Query: 282 VLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGS 341
+DP R+T QAL+HPWV AA+ ++ K L ++ LK A ++ S
Sbjct: 337 TVDPGARMTALQALRHPWVVSMAAS-----SSMKNLHRSISQNLLKRASSRCQSTKSAQS 391
Query: 342 ASSSHGSIQESHKASR 357
SS + S+K+ R
Sbjct: 392 TRSSRST--RSNKSRR 405
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 238 bits (608), Expect = 7e-63
Identities = 134/317 (42%), Positives = 199/317 (62%), Gaps = 13/317 (4%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ELG+GA S+V RC +K + + YA K++ D + + E + L H
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
PNI++L + LV +LVTGGELF+ IV + YYSE DA+ + QILE+V ++H++
Sbjct: 71 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
IVHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR
Sbjct: 131 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T QAL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 335 ASSR---LGSASSSHGS 348
SR +G SS+ S
Sbjct: 309 LVSRNFSVGRQSSAPAS 325
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 238 bits (608), Expect = 7e-63
Identities = 145/399 (36%), Positives = 224/399 (56%), Gaps = 33/399 (8%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ++G+GA S+V RC + T YA K++ D + + E + L H
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+
Sbjct: 71 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
G+VHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR A
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T +AL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSA----------------SSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKI 378
++R SA S+ + + S K + P+ ++ + +G K
Sbjct: 309 LATRNFSAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKE 368
Query: 379 QGDGAQAAV-----KGAQAELMKV--QALEKVKGADINA 410
D A + K + E++K Q +E V D A
Sbjct: 369 SSDSANTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEA 407
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 238 bits (607), Expect = 9e-63
Identities = 145/400 (36%), Positives = 224/400 (56%), Gaps = 34/400 (8%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ++G+GA S+V RC + T YA K++ D + + E + L H
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+
Sbjct: 71 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
G+VHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR A
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T +AL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSA-----------------SSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEK 377
++R SA S+ + + S K + P+ ++ + +G K
Sbjct: 309 LATRNFSAAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIK 368
Query: 378 IQGDGAQAAV-----KGAQAELMKV--QALEKVKGADINA 410
D A + K + E++K Q +E V D A
Sbjct: 369 ESSDSANTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEA 408
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 238 bits (606), Expect = 1e-62
Identities = 136/338 (40%), Positives = 205/338 (60%), Gaps = 11/338 (3%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ++G+GA S+V RC + T YA K++ D + + E + L H
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+
Sbjct: 71 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
G+VHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR A
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAV-KAV 333
+ +++ ++P KR+T +AL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 334 VASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKA 371
+A+ +A S + K S D + +ED KA
Sbjct: 309 LATRNFSAAKSLLNKKADGVKESSDSANTTIEDEDAKA 346
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 236 bits (602), Expect = 3e-62
Identities = 130/311 (41%), Positives = 196/311 (63%), Gaps = 10/311 (3%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ++G+GA S+V RC + T YA K++ D + + E + L H
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+
Sbjct: 71 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
G+VHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR A
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T +AL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSASSS 345
++R SA+ S
Sbjct: 309 LATRNFSAAKS 319
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 234 bits (597), Expect = 1e-61
Identities = 129/308 (41%), Positives = 194/308 (62%), Gaps = 10/308 (3%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ++G+GA S+V RC + T YA K++ D + + E + L H
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+
Sbjct: 71 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
G+VHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR A
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T +AL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 335 ASSRLGSA 342
++R SA
Sbjct: 309 LATRNFSA 316
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 234 bits (596), Expect = 2e-61
Identities = 131/294 (44%), Positives = 178/294 (60%), Gaps = 8/294 (2%)
Query: 46 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDK---KIVRTEIGVLLRLSHPNII 102
+E +G G ++V C+ + T++ YA+K++ K+ K +V +EI ++ LSHPNI+
Sbjct: 356 YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIV 415
Query: 103 KLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVH 162
KL E++ET EI L+LE V GG+LFD I+E + E DAA + + +A+ ++H+ IVH
Sbjct: 416 KLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVH 475
Query: 163 RDLKPENLL-YATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPE 221
RDLKPENLL LK+ADFGL+K V + TVCGTP Y APEIL YG E
Sbjct: 476 RDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIF--TVCGTPTYVAPEILSEKGYGLE 533
Query: 222 VDMWSVGIITYILLCGFEPFYD-ERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKL 280
VDMW+ G+I YILLCGF PF ER +F I + F+ P+WD +S AKDLV +L
Sbjct: 534 VDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRL 593
Query: 281 IVLDPKKRLTTFQALQHPWV-TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAV 333
+V+DPKKR T Q LQHPW+ T N V E + R + K V+ V
Sbjct: 594 LVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQV 647
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 233 bits (595), Expect = 2e-61
Identities = 127/304 (41%), Positives = 192/304 (63%), Gaps = 10/304 (3%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ++G+GA S+V RC + T YA K++ D + + E + L H
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+
Sbjct: 71 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
G+VHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR A
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T +AL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 335 ASSR 338
++R
Sbjct: 309 LATR 312
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 233 bits (595), Expect = 2e-61
Identities = 127/304 (41%), Positives = 192/304 (63%), Gaps = 10/304 (3%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ++G+GA S+V RC + T YA K++ D + + E + L H
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+
Sbjct: 71 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
G+VHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR A
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T +AL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 335 ASSR 338
++R
Sbjct: 309 LATR 312
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 233 bits (595), Expect = 2e-61
Identities = 127/304 (41%), Positives = 192/304 (63%), Gaps = 10/304 (3%)
Query: 43 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSH 98
+D +++ ++G+GA S+V RC + T YA K++ D + + E + L H
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 70
Query: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
NI++L + LV +LVTGGELF+ IV + YYSE DA+ ++QILEAV + H+
Sbjct: 71 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 217
G+VHRDLKPENLL A+ A +K+ADFGL+ ++ Q GTPGY +PE+LR A
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 218 YGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDL 276
YG VD+W+ G+I YILL G+ PF+DE DQ ++++I Y F SP WD V+ AK+L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDE--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 277 VRKLIVLDPKKRLTTFQALQHPWVTGKA--ANFVHMDTAQKKLQEFNARRKLKAAVKAVV 334
+ +++ ++P KR+T +AL+HPWV ++ A+ +H + L++FNARRKLK A+ +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 335 ASSR 338
++R
Sbjct: 309 LATR 312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,624,822
Number of Sequences: 37866
Number of extensions: 771866
Number of successful extensions: 5206
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 603
Number of HSP's successfully gapped in prelim test: 232
Number of HSP's that attempted gapping in prelim test: 2675
Number of HSP's gapped (non-prelim): 1101
length of query: 473
length of database: 18,247,518
effective HSP length: 106
effective length of query: 367
effective length of database: 14,233,722
effective search space: 5223775974
effective search space used: 5223775974
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.