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Search of human proteins with 4502167
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
sapiens]
(770 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 1567 0.0
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 1519 0.0
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 1414 0.0
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa... 1283 0.0
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s... 1130 0.0
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ... 746 0.0
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ... 744 0.0
gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ... 640 0.0
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ... 382 e-106
gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor... 257 2e-68
gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ... 254 3e-67
gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo sapi... 72 2e-12
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s... 67 5e-11
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s... 67 5e-11
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ... 67 5e-11
gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo sap... 67 8e-11
gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2 ... 66 1e-10
gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2 p... 66 1e-10
gi|73760409 tissue factor pathway inhibitor isoform b precursor ... 65 2e-10
gi|5454114 tissue factor pathway inhibitor isoform a precursor [... 65 2e-10
gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1 ... 63 9e-10
gi|154759255 collagen, type XXVIII precursor [Homo sapiens] 63 9e-10
gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP... 62 2e-09
gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP... 62 2e-09
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 61 3e-09
gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo sap... 61 3e-09
gi|5730091 tissue factor pathway inhibitor 2 [Homo sapiens] 59 2e-08
gi|28212222 WFIKKN2 protein [Homo sapiens] 59 2e-08
gi|145309328 papilin [Homo sapiens] 57 5e-08
gi|60498973 myelin transcription factor 1-like [Homo sapiens] 57 6e-08
>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
sapiens]
Length = 770
Score = 1567 bits (4058), Expect = 0.0
Identities = 770/770 (100%), Positives = 770/770 (100%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
Query: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD 360
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
Sbjct: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD 360
Query: 361 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 420
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Sbjct: 361 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 420
Query: 421 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 480
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Sbjct: 421 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 480
Query: 481 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 540
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Sbjct: 481 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 540
Query: 541 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 600
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Sbjct: 541 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 600
Query: 601 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 660
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Sbjct: 601 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 660
Query: 661 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 720
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Sbjct: 661 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 720
Query: 721 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 721 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770
>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
sapiens]
Length = 751
Score = 1519 bits (3933), Expect = 0.0
Identities = 750/770 (97%), Positives = 751/770 (97%), Gaps = 19/770 (2%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
Query: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD 360
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
Sbjct: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA---------------- 344
Query: 361 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 420
+PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Sbjct: 345 ---IPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 401
Query: 421 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 480
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Sbjct: 402 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 461
Query: 481 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 540
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Sbjct: 462 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 521
Query: 541 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 600
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Sbjct: 522 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 581
Query: 601 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 660
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Sbjct: 582 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 641
Query: 661 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 720
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Sbjct: 642 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 701
Query: 721 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 702 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 751
>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
sapiens]
Length = 714
Score = 1414 bits (3661), Expect = 0.0
Identities = 696/696 (100%), Positives = 696/696 (100%)
Query: 75 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
Query: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
Query: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 254
NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
Query: 255 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 314
EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG
Sbjct: 199 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 258
Query: 315 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 374
KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA
Sbjct: 259 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 318
Query: 375 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 434
VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH
Sbjct: 319 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 378
Query: 435 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 494
FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML
Sbjct: 379 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 438
Query: 495 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 554
KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV
Sbjct: 439 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 498
Query: 555 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 614
AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS
Sbjct: 499 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 558
Query: 615 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 674
LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE
Sbjct: 559 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 618
Query: 675 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 734
FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG
Sbjct: 619 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 678
Query: 735 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770
VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 679 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714
>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
sapiens]
Length = 695
Score = 1283 bits (3321), Expect = 0.0
Identities = 657/770 (85%), Positives = 665/770 (86%), Gaps = 75/770 (9%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA----- 235
Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC 300
EVEEE + E+ + + VEE E E E
Sbjct: 236 ------------EVEEEEADDDEDDEDG------------DEVEEEAEEPYEEATER--- 268
Query: 301 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD 360
S + TT +
Sbjct: 269 -------------------------------------------TTSIATTTTTTTESVEE 285
Query: 361 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 420
V++PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Sbjct: 286 VVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA 345
Query: 421 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 480
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Sbjct: 346 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL 405
Query: 481 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 540
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Sbjct: 406 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER 465
Query: 541 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 600
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Sbjct: 466 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET 525
Query: 601 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 660
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Sbjct: 526 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN 585
Query: 661 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 720
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Sbjct: 586 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 645
Query: 721 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 646 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 695
>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
sapiens]
Length = 639
Score = 1130 bits (2924), Expect = 0.0
Identities = 583/696 (83%), Positives = 591/696 (84%), Gaps = 75/696 (10%)
Query: 75 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
Query: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
Query: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 254
NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA EV
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA-----------------EV 181
Query: 255 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 314
EEE + E+ + + VEE E E E
Sbjct: 182 EEEEADDDEDDEDG------------DEVEEEAEEPYEEATER----------------- 212
Query: 315 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 374
S + TT + V++PTTAASTPDA
Sbjct: 213 -----------------------------TTSIATTTTTTTESVEEVVRVPTTAASTPDA 243
Query: 375 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 434
VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH
Sbjct: 244 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 303
Query: 435 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 494
FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML
Sbjct: 304 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 363
Query: 495 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 554
KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV
Sbjct: 364 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 423
Query: 555 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 614
AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS
Sbjct: 424 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 483
Query: 615 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 674
LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE
Sbjct: 484 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 543
Query: 675 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 734
FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG
Sbjct: 544 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 603
Query: 735 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770
VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 604 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 639
Score = 397 bits (1019), Expect = e-110
Identities = 213/288 (73%), Positives = 215/288 (74%), Gaps = 56/288 (19%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
MLPGLALLLLAAWTARALEV E QI N + +QN W G K
Sbjct: 1 MLPGLALLLLAAWTARALEV--------YPELQITNVV-EANQPVTIQN--WCK--RGRK 47
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
C KTHPHFVIPYRCLVG
Sbjct: 48 QC-------------------------------------------KTHPHFVIPYRCLVG 64
Query: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 65 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 124
Query: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 125 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 184
Query: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR 288
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR
Sbjct: 185 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR 232
>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
[Homo sapiens]
Length = 751
Score = 746 bits (1925), Expect = 0.0
Identities = 398/784 (50%), Positives = 522/784 (66%), Gaps = 67/784 (8%)
Query: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
Query: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
Query: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236
D+F G E+VCCP + +V + EED+ + + DY D + + A+ E+ E
Sbjct: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251
Query: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREV 290
+E DDED+E+G+EV E+ + Y+ E T + T + + + V+ V
Sbjct: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 350
CS++A TGPCRA++ RWYFD+++GKC F YGGCGGNRNNF++E+YCMAVC + +
Sbjct: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP---- 365
Query: 351 KTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVM 410
P LPT + VD Y ET D+NEHA FQKAKE+LE +HR RM +V
Sbjct: 366 ----------PTPLPT------NDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVK 409
Query: 411 REWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRR 470
+EWEEAE QAKNLPKA+++ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR
Sbjct: 410 KEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRR 469
Query: 471 LALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQV 530
+ALENY+ ALQ+ PPRP + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQV
Sbjct: 470 MALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQV 529
Query: 531 MTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGN 590
MTHL VI ER NQSLSLLY VP VA+EIQ+E+DELLQ+++ A+M
Sbjct: 530 MTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM---------- 572
Query: 591 DALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AA 646
D S++ET V V+ E S +++ P+H F PA ENE V + A
Sbjct: 573 DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGA 626
Query: 647 DRGLTTRPGSGLTNIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGL 705
+ + N+ +E +VK M G E + + ED + A+IGL
Sbjct: 627 EEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGL 686
Query: 706 MVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFF 765
+V V IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+
Sbjct: 687 LVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYL 746
Query: 766 EQMQ 769
EQMQ
Sbjct: 747 EQMQ 750
>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
[Homo sapiens]
Length = 763
Score = 744 bits (1920), Expect = 0.0
Identities = 402/798 (50%), Positives = 528/798 (66%), Gaps = 83/798 (10%)
Query: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
Query: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
Query: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236
D+F G E+VCCP + +V + EED+ + + DY D + + A+ E+ E
Sbjct: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251
Query: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREV 290
+E DDED+E+G+EV E+ + Y+ E T + T + + + V+ V
Sbjct: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 350
CS++A TGPCRA++ RWYFD+++GKC F YGGCGGNRNNF++E+YCMAVC + +
Sbjct: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP---- 365
Query: 351 KTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVM 410
P LPT + VD Y ET D+NEHA FQKAKE+LE +HR RM +V
Sbjct: 366 ----------PTPLPT------NDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVK 409
Query: 411 REWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRR 470
+EWEEAE QAKNLPKA+++ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR
Sbjct: 410 KEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRR 469
Query: 471 LALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQV 530
+ALENY+ ALQ+ PPRP + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQV
Sbjct: 470 MALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQV 529
Query: 531 MTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGN 590
MTHL VI ER NQSLSLLY VP VA+EIQ+E+DELLQ+++ A+M
Sbjct: 530 MTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM---------- 572
Query: 591 DALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE-VEPVDARPAADRG 649
D S++ET V V+ E S +++ P+H F PA ENE +P P
Sbjct: 573 DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENEDTQPELYHPMKKGS 626
Query: 650 LTTRPGSGLTNIKTEEI-SEVKMDAEFRHDSGYEVHHQKLVFFAEDVGS----------- 697
GL + + I S+ K+D D +V ++++F AE VG
Sbjct: 627 GVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDV--KEMIFNAERVGGLEEERESVGPL 684
Query: 698 ------NKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSK 751
+ A+IGL+V V IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+K
Sbjct: 685 REDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNK 744
Query: 752 MQQNGYENPTYKFFEQMQ 769
MQ +GYENPTYK+ EQMQ
Sbjct: 745 MQNHGYENPTYKYLEQMQ 762
>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
[Homo sapiens]
Length = 695
Score = 640 bits (1652), Expect = 0.0
Identities = 370/779 (47%), Positives = 478/779 (61%), Gaps = 113/779 (14%)
Query: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
Query: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
Query: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
Query: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVV-EVAEEEEVA 235
D+F G E+VCCP + K++ V++EEE
Sbjct: 193 DQFHGTEYVCCP---------------------------------QTKIIGSVSKEEEEE 219
Query: 236 EVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQA 295
+ EEEE +D+E+D D + E E E+ TE E EEVV +
Sbjct: 220 DEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVD---EDDEDEEEGEEVVED------ 270
Query: 296 ETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQE 355
+Y+D +G D E GS + S + T +
Sbjct: 271 ---------RDYYYDTFKGD----------------DYNEENPTEPGSDGTMSDKEITHD 305
Query: 356 PLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEE 415
VK+P T T D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEE
Sbjct: 306 ------VKVPPTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEE 358
Query: 416 AERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALEN 475
AE QAKNLPKA+++ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALEN
Sbjct: 359 AELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALEN 418
Query: 476 YITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLR 535
Y+ ALQ+ PPRP + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL
Sbjct: 419 YLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLH 478
Query: 536 VIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMP 595
VI ER NQSLSLLY VP VA+EIQ+E+DELLQ+++ A+M D
Sbjct: 479 VIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTA 521
Query: 596 SLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLT 651
S++ET V V+ E S +++ P+H F PA ENE V + A+ +
Sbjct: 522 SISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVI 575
Query: 652 TRPGSGLTNIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGV 710
N+ +E +VK M G E + + ED + A+IGL+V V
Sbjct: 576 NSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAV 635
Query: 711 VIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 769
IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 636 AIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694
>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
[Homo sapiens]
Length = 522
Score = 382 bits (981), Expect = e-106
Identities = 215/411 (52%), Positives = 278/411 (67%), Gaps = 29/411 (7%)
Query: 364 LPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNL 423
+P T T D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNL
Sbjct: 135 VPPTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNL 193
Query: 424 PKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAV 483
PKA+++ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+
Sbjct: 194 PKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSD 253
Query: 484 PPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQ 543
PPRP + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQ
Sbjct: 254 PPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQ 313
Query: 544 SLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTT 603
SLSLLY VP VA+EIQ+E+DELLQ+++ A+M D S++ET
Sbjct: 314 SLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVD 356
Query: 604 VELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLT 659
V V+ E S +++ P+H F PA ENE V + A+ +
Sbjct: 357 VR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDE 410
Query: 660 NIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVI 718
N+ +E +VK M G E + + ED + A+IGL+V V IATVIVI
Sbjct: 411 NMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVI 470
Query: 719 TLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 769
+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 471 SLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 521
Score = 152 bits (385), Expect = 9e-37
Identities = 75/123 (60%), Positives = 93/123 (75%), Gaps = 10/123 (8%)
Query: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
Query: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKS--RFVTPFK 132
Query: 117 CLV 119
CLV
Sbjct: 133 CLV 135
>gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor
[Homo sapiens]
Length = 651
Score = 257 bits (657), Expect = 2e-68
Identities = 157/401 (39%), Positives = 234/401 (58%), Gaps = 49/401 (12%)
Query: 373 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 432
D VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+
Sbjct: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351
Query: 433 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 492
+HFQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V
Sbjct: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411
Query: 493 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 552
L++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P
Sbjct: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471
Query: 553 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 612
+A+E++ ++ ELL E L PS E P G
Sbjct: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502
Query: 613 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 670
S D LQP S AD+ + E A P ++ + E E K
Sbjct: 503 SSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERK 550
Query: 671 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 726
++A G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK
Sbjct: 551 VNASV--PRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 608
Query: 727 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 767
Y +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 609 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649
Score = 210 bits (535), Expect = 4e-54
Identities = 157/488 (32%), Positives = 232/488 (47%), Gaps = 53/488 (10%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
+LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++
Sbjct: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL
Sbjct: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
Query: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F
Sbjct: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
Query: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
RGVE+VCCP D S A D S W GS VE AE+EE E
Sbjct: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
Query: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299
+ DD + E EEE P T T T T+ V+ G
Sbjct: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGF 310
Query: 300 CRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---Q 347
RA + D+ E + + N E+ MA S A++ Q
Sbjct: 311 LRAKM-----DLEERRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQ 355
Query: 348 SLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMS 407
S+L+T +E ++ + +L T A+ A+ E A Q + ER+
Sbjct: 356 SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVL 410
Query: 408 QVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLND 467
+R + AE++ +++ ++H+Q V +++ E A + + V TH+ +E +N
Sbjct: 411 LALRRYLRAEQK-------EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQ 462
Query: 468 RRRLALEN 475
L +N
Sbjct: 463 SLGLLDQN 470
>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
[Homo sapiens]
Length = 650
Score = 254 bits (648), Expect = 3e-67
Identities = 153/401 (38%), Positives = 229/401 (57%), Gaps = 50/401 (12%)
Query: 373 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 432
D VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+
Sbjct: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351
Query: 433 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 492
+HFQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V
Sbjct: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411
Query: 493 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 552
L++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P
Sbjct: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471
Query: 553 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 612
+A+E++ ++ ELL E L PS E P G
Sbjct: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502
Query: 613 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 670
S D LQP S D P +G T + + K + + +
Sbjct: 503 SSEDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYE 547
Query: 671 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 726
G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK
Sbjct: 548 RKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 607
Query: 727 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 767
Y +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 608 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
Score = 210 bits (535), Expect = 4e-54
Identities = 157/488 (32%), Positives = 232/488 (47%), Gaps = 53/488 (10%)
Query: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
+LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++
Sbjct: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
Query: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL
Sbjct: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
Query: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F
Sbjct: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
Query: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
RGVE+VCCP D S A D S W GS VE AE+EE E
Sbjct: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
Query: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299
+ DD + E EEE P T T T T+ V+ G
Sbjct: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGF 310
Query: 300 CRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---Q 347
RA + D+ E + + N E+ MA S A++ Q
Sbjct: 311 LRAKM-----DLEERRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQ 355
Query: 348 SLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMS 407
S+L+T +E ++ + +L T A+ A+ E A Q + ER+
Sbjct: 356 SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVL 410
Query: 408 QVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLND 467
+R + AE++ +++ ++H+Q V +++ E A + + V TH+ +E +N
Sbjct: 411 LALRRYLRAEQK-------EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQ 462
Query: 468 RRRLALEN 475
L +N
Sbjct: 463 SLGLLDQN 470
>gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo
sapiens]
Length = 252
Score = 72.0 bits (175), Expect = 2e-12
Identities = 39/103 (37%), Positives = 48/103 (46%), Gaps = 16/103 (15%)
Query: 255 EEEAEEPYEEATERTTS-IATTTTTTTESVEEVVR---------------EVCSEQAETG 298
+EE + TE T +AT+ SV R E C+ A TG
Sbjct: 81 KEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTG 140
Query: 299 PCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
PCRA RWYFDV C F YGGC GN+N++ +EE CM C
Sbjct: 141 PCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRC 183
Score = 64.3 bits (155), Expect = 4e-10
Identities = 25/60 (41%), Positives = 36/60 (60%)
Query: 284 EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS 343
E + + C G CRA + RW+++VT+G C F YGGC GN NN+ T+E C+ C +
Sbjct: 31 ERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCAT 90
>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
sapiens]
Length = 2971
Score = 67.4 bits (163), Expect = 5e-11
Identities = 27/92 (29%), Positives = 47/92 (51%)
Query: 256 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 315
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 2871 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2930
Query: 316 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQ 347
CA F+YGGCGGN N F +++ C VC +++
Sbjct: 2931 CARFWYGGCGGNENKFGSQKECEKVCAPVLAK 2962
>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
sapiens]
Length = 3177
Score = 67.4 bits (163), Expect = 5e-11
Identities = 27/92 (29%), Positives = 47/92 (51%)
Query: 256 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 315
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 3077 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 3136
Query: 316 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQ 347
CA F+YGGCGGN N F +++ C VC +++
Sbjct: 3137 CARFWYGGCGGNENKFGSQKECEKVCAPVLAK 3168
>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
sapiens]
Length = 2570
Score = 67.4 bits (163), Expect = 5e-11
Identities = 27/92 (29%), Positives = 47/92 (51%)
Query: 256 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 315
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 2470 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2529
Query: 316 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQ 347
CA F+YGGCGGN N F +++ C VC +++
Sbjct: 2530 CARFWYGGCGGNENKFGSQKECEKVCAPVLAK 2561
>gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo
sapiens]
Length = 89
Score = 66.6 bits (161), Expect = 8e-11
Identities = 25/61 (40%), Positives = 40/61 (65%)
Query: 281 ESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAV 340
+++++++ VC+ E GPC+ ++RW+F+ G+C F YGGCGGN NNF +E C
Sbjct: 26 DTIKDLLPNVCAFPMEKGPCQTYMTRWFFNFETGECELFAYGGCGGNSNNFLRKEKCEKF 85
Query: 341 C 341
C
Sbjct: 86 C 86
>gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2
precursor [Homo sapiens]
Length = 513
Score = 66.2 bits (160), Expect = 1e-10
Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 6/117 (5%)
Query: 270 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 329
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 330 NFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDEN 386
N+ EE C+ C S+ + + P+ + S +D +LE N
Sbjct: 289 NYLREEECILACRGVQGPSMER--RHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPN 343
Score = 60.5 bits (145), Expect = 6e-09
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 6/79 (7%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 350
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C + +
Sbjct: 375 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVF 434
Query: 351 KTTQEPLARDPVKLPTTAA 369
+E + +P+T +
Sbjct: 435 GLRRE------IPIPSTGS 447
>gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2
precursor [Homo sapiens]
Length = 513
Score = 66.2 bits (160), Expect = 1e-10
Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 6/117 (5%)
Query: 270 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 329
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 330 NFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDEN 386
N+ EE C+ C S+ + + P+ + S +D +LE N
Sbjct: 289 NYLREEECILACRGVQGPSMER--RHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPN 343
Score = 60.5 bits (145), Expect = 6e-09
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 6/79 (7%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 350
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C + +
Sbjct: 375 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVF 434
Query: 351 KTTQEPLARDPVKLPTTAA 369
+E + +P+T +
Sbjct: 435 GLRRE------IPIPSTGS 447
>gi|73760409 tissue factor pathway inhibitor isoform b precursor
[Homo sapiens]
Length = 251
Score = 65.5 bits (158), Expect = 2e-10
Identities = 27/80 (33%), Positives = 48/80 (60%)
Query: 274 TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT 333
T T T +++ C+ +A+ GPC+A++ R++F++ +C F YGGC GN+N F++
Sbjct: 37 TIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFES 96
Query: 334 EEYCMAVCGSAMSQSLLKTT 353
E C +C + ++KTT
Sbjct: 97 LEECKKMCTRDNANRIIKTT 116
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 251 GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFD 310
G E + E EE + T T ++++ + C + + G CR I+R++++
Sbjct: 86 GCEGNQNRFESLEECKKMCTRDNANRIIKT-TLQQEKPDFCFLEEDPGICRGYITRYFYN 144
Query: 311 VTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
+C F YGGC GN NNF+T E C +C
Sbjct: 145 NQTKQCERFKYGGCLGNMNNFETLEECKNIC 175
>gi|5454114 tissue factor pathway inhibitor isoform a precursor
[Homo sapiens]
Length = 304
Score = 65.5 bits (158), Expect = 2e-10
Identities = 27/80 (33%), Positives = 48/80 (60%)
Query: 274 TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT 333
T T T +++ C+ +A+ GPC+A++ R++F++ +C F YGGC GN+N F++
Sbjct: 37 TIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFES 96
Query: 334 EEYCMAVCGSAMSQSLLKTT 353
E C +C + ++KTT
Sbjct: 97 LEECKKMCTRDNANRIIKTT 116
Score = 62.8 bits (151), Expect = 1e-09
Identities = 26/61 (42%), Positives = 36/61 (59%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 350
C A+ G CRA +R+Y++ GKC PF Y GCGGN NNF +++ C+ C Q +
Sbjct: 217 CLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRIS 276
Query: 351 K 351
K
Sbjct: 277 K 277
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 251 GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFD 310
G E + E EE + T T ++++ + C + + G CR I+R++++
Sbjct: 86 GCEGNQNRFESLEECKKMCTRDNANRIIKT-TLQQEKPDFCFLEEDPGICRGYITRYFYN 144
Query: 311 VTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
+C F YGGC GN NNF+T E C +C
Sbjct: 145 NQTKQCERFKYGGCLGNMNNFETLEECKNIC 175
>gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1
precursor [Homo sapiens]
Length = 529
Score = 63.2 bits (152), Expect = 9e-10
Identities = 29/72 (40%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 270 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 329
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 330 NFDTEEYCMAVC 341
N+ EE C+ C
Sbjct: 289 NYLREEECILAC 300
Score = 60.5 bits (145), Expect = 6e-09
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 6/79 (7%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 350
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C + +
Sbjct: 391 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVF 450
Query: 351 KTTQEPLARDPVKLPTTAA 369
+E + +P+T +
Sbjct: 451 GLRRE------IPIPSTGS 463
>gi|154759255 collagen, type XXVIII precursor [Homo sapiens]
Length = 1125
Score = 63.2 bits (152), Expect = 9e-10
Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 4/111 (3%)
Query: 231 EEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREV 290
++E++E D DEDD+ + + + P ++E TT+ +T + E+
Sbjct: 1016 QKEISESLSVTRDQDEDDKAPEPTWAD-DLPATTSSEATTTPRPLLSTPVDGAED---PR 1071
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
C E + G C + RWY+D CA F++ GC G+ N F++E+ C C
Sbjct: 1072 CLEALKPGNCGEYVVRWYYDKQVNSCARFWFSGCNGSGNRFNSEKECQETC 1122
>gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP
domains 1 isoform 2 [Homo sapiens]
Length = 117
Score = 62.4 bits (150), Expect = 2e-09
Identities = 23/57 (40%), Positives = 34/57 (59%)
Query: 285 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
++ ++VC ETGPC A W++D + C+ F YGGC GN NNF ++ C+ C
Sbjct: 55 DLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTC 111
>gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP
domains 1 isoform 1 precursor [Homo sapiens]
Length = 133
Score = 62.4 bits (150), Expect = 2e-09
Identities = 23/57 (40%), Positives = 34/57 (59%)
Query: 285 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
++ ++VC ETGPC A W++D + C+ F YGGC GN NNF ++ C+ C
Sbjct: 71 DLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTC 127
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 61.2 bits (147), Expect = 3e-09
Identities = 41/118 (34%), Positives = 48/118 (40%), Gaps = 20/118 (16%)
Query: 234 VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSE 293
V+ EEEE EDDE + E EE Y++ S + CS
Sbjct: 2836 VSHAEEEERVPPEDDEYSEYSEYSVEE-YQDPEAPWDS----------------DDPCSL 2878
Query: 294 QAETGPCRAMISRWYFDVTEGK---CAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQS 348
+ G C A RWY G C PF YGGCGGN N F T E C C + QS
Sbjct: 2879 PLDEGSCTAYTLRWYHRAVTGSTEACHPFVYGGCGGNANRFGTREACERRCPPRVVQS 2936
>gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo
sapiens]
Length = 352
Score = 61.2 bits (147), Expect = 3e-09
Identities = 26/52 (50%), Positives = 30/52 (57%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCG 342
C+ GPCRA I W FD +GKC F YGGC GN N F +E+ C CG
Sbjct: 287 CNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYCG 338
Score = 57.8 bits (138), Expect = 4e-08
Identities = 33/103 (32%), Positives = 46/103 (44%), Gaps = 14/103 (13%)
Query: 261 PYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFF 320
P EE + T T +S C GPC M SR++++ T C F
Sbjct: 209 PQEEEGSGGGQLVTEVTKKEDS--------CQLGYSAGPCMGMTSRYFYNGTSMACETFQ 260
Query: 321 YGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVK 363
YGGC GN NNF TE+ C+ C + + +L P+ R P +
Sbjct: 261 YGGCMGNGNNFVTEKECLQTCRTVAACNL------PIVRGPCR 297
>gi|5730091 tissue factor pathway inhibitor 2 [Homo sapiens]
Length = 235
Score = 58.9 bits (141), Expect = 2e-08
Identities = 25/53 (47%), Positives = 31/53 (58%)
Query: 289 EVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
E+C + GPCRA++ R+Y+D C F YGGC GN NNF T E C C
Sbjct: 34 EICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDAC 86
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/57 (38%), Positives = 30/57 (52%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQ 347
C + G C A ++R+YF+ C F Y GCGGN NNF + E C C A+ +
Sbjct: 158 CYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKK 214
Score = 39.7 bits (91), Expect = 0.011
Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 3/60 (5%)
Query: 285 EVVREVCSEQAETGP-CRAMISRWYFDVTEGKCAPFFYGGCGGNR--NNFDTEEYCMAVC 341
E V +VC Q C +++F+++ C FF GGC NR N F E CM C
Sbjct: 90 EKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFC 149
>gi|28212222 WFIKKN2 protein [Homo sapiens]
Length = 576
Score = 58.5 bits (140), Expect = 2e-08
Identities = 24/51 (47%), Positives = 30/51 (58%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341
CS A GPC+A RW ++ G+C F YGGC GN NNF++ E C C
Sbjct: 386 CSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESC 436
Score = 45.8 bits (107), Expect = 1e-04
Identities = 19/53 (35%), Positives = 27/53 (50%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS 343
C + ++ C +RW+FD C F +G C N N+F+T E CM C S
Sbjct: 328 CLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLACMS 380
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 57.4 bits (137), Expect = 5e-08
Identities = 23/55 (41%), Positives = 33/55 (60%)
Query: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAM 345
C + G C +RWYF + G+C F+YGGC GN NNF +E+ CM+ C ++
Sbjct: 727 CLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQGSL 781
>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
Length = 1184
Score = 57.0 bits (136), Expect = 6e-08
Identities = 32/77 (41%), Positives = 44/77 (57%), Gaps = 2/77 (2%)
Query: 191 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 250
++SD + D +E+D + D D G ED+ E + EE E+EEE+ DDDED ED
Sbjct: 91 DDSDGTEDMDEKEEDEGEEYS-EDND-EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGED 148
Query: 251 GDEVEEEAEEPYEEATE 267
++ EEE EE EE E
Sbjct: 149 VEDEEEEEEEEEEEEEE 165
Score = 41.2 bits (95), Expect = 0.004
Identities = 50/213 (23%), Positives = 79/213 (37%), Gaps = 36/213 (16%)
Query: 187 CPLAEESDNVDSADAEE-----------DDSDVWWGGADTDYADGSEDKVVEVAEEEEVA 235
CPLA++ D E D S V + D +DG+ED ++ EE+E
Sbjct: 55 CPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSV----DECDDSDGTED--MDEKEEDEGE 108
Query: 236 EVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQA 295
E E+ + ++DE+ +E + E EE EE E E EE E E+
Sbjct: 109 EYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEEN 168
Query: 296 ETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQE 355
E +R D + + NN + + Y +++SLL +
Sbjct: 169 EDHQMNCHNTRIMQDTEK------------DDNNNDEYDNY-----DELVAKSLLNLGK- 210
Query: 356 PLARDPVKLPTTAASTPDAVDKYLETPGDENEH 388
+A D T + LE D+NE+
Sbjct: 211 -IAEDAAYRARTESEMNSNTSNSLEDDSDKNEN 242
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,800,168
Number of Sequences: 37866
Number of extensions: 1408643
Number of successful extensions: 20719
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 470
Number of HSP's successfully gapped in prelim test: 400
Number of HSP's that attempted gapping in prelim test: 9621
Number of HSP's gapped (non-prelim): 5723
length of query: 770
length of database: 18,247,518
effective HSP length: 110
effective length of query: 660
effective length of database: 14,082,258
effective search space: 9294290280
effective search space used: 9294290280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.