Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 41327769
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41327769 Rho/Rac guanine nucleotide exchange factor 18
isoform a [Homo sapiens]
(1015 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 1994 0.0
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 1994 0.0
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 638 0.0
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 597 e-170
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 597 e-170
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 597 e-170
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 466 e-131
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 466 e-131
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 462 e-130
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 189 1e-47
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 189 1e-47
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 183 8e-46
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 177 3e-44
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 177 3e-44
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 177 3e-44
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 92 3e-18
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 92 3e-18
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 86 2e-16
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 86 2e-16
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 86 2e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 85 4e-16
gi|38373682 pleckstrin homology domain containing family G membe... 72 3e-12
gi|111154084 pleckstrin homology domain containing family G memb... 72 3e-12
gi|111154088 pleckstrin homology domain containing family G memb... 72 3e-12
gi|111154080 pleckstrin homology domain containing family G memb... 72 3e-12
gi|111154078 pleckstrin homology domain containing family G memb... 72 3e-12
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 70 1e-11
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 69 2e-11
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 69 2e-11
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 69 2e-11
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
[Homo sapiens]
Length = 1173
Score = 1994 bits (5167), Expect = 0.0
Identities = 1015/1015 (100%), Positives = 1015/1015 (100%)
Query: 1 MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE 60
MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE
Sbjct: 159 MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE 218
Query: 61 DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL
Sbjct: 219 DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 278
Query: 121 KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV 180
KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV
Sbjct: 279 KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV 338
Query: 181 IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI 240
IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI
Sbjct: 339 IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI 398
Query: 241 VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS 300
VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS
Sbjct: 399 VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS 458
Query: 301 ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI 360
ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI
Sbjct: 459 ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI 518
Query: 361 LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI 420
LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI
Sbjct: 519 LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI 578
Query: 421 YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL 480
YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL
Sbjct: 579 YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL 638
Query: 481 IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI 540
IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI
Sbjct: 639 IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI 698
Query: 541 CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP 600
CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP
Sbjct: 699 CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP 758
Query: 601 NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI 660
NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI
Sbjct: 759 NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI 818
Query: 661 AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE 720
AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE
Sbjct: 819 AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE 878
Query: 721 QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA 780
QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA
Sbjct: 879 QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA 938
Query: 781 QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG 840
QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG
Sbjct: 939 QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG 998
Query: 841 VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG 900
VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG
Sbjct: 999 VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG 1058
Query: 901 KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP 960
KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP
Sbjct: 1059 KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP 1118
Query: 961 GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF 1015
GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF
Sbjct: 1119 GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF 1173
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 1994 bits (5167), Expect = 0.0
Identities = 1015/1015 (100%), Positives = 1015/1015 (100%)
Query: 1 MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE 60
MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE
Sbjct: 1 MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE 60
Query: 61 DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL
Sbjct: 61 DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
Query: 121 KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV 180
KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV
Sbjct: 121 KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV 180
Query: 181 IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI 240
IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI
Sbjct: 181 IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI 240
Query: 241 VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS 300
VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS
Sbjct: 241 VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS 300
Query: 301 ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI 360
ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI
Sbjct: 301 ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI 360
Query: 361 LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI 420
LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI
Sbjct: 361 LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI 420
Query: 421 YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL 480
YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL
Sbjct: 421 YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL 480
Query: 481 IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI 540
IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI
Sbjct: 481 IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI 540
Query: 541 CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP 600
CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP
Sbjct: 541 CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP 600
Query: 601 NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI 660
NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI
Sbjct: 601 NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI 660
Query: 661 AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE 720
AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE
Sbjct: 661 AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE 720
Query: 721 QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA 780
QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA
Sbjct: 721 QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA 780
Query: 781 QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG 840
QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG
Sbjct: 781 QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG 840
Query: 841 VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG 900
VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG
Sbjct: 841 VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG 900
Query: 901 KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP 960
KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP
Sbjct: 901 KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP 960
Query: 961 GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF 1015
GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF
Sbjct: 961 GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF 1015
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 638 bits (1646), Expect = 0.0
Identities = 372/811 (45%), Positives = 511/811 (63%), Gaps = 44/811 (5%)
Query: 18 PGTQLGPI----TGEMDEADSAFLKFKQTADDSLSL--TSPNTESIFVEDPYTASLRSEI 71
PGT L T E+D + + +D+ L +SP+TES +ED +SL S++
Sbjct: 760 PGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDL 819
Query: 72 ESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRAL 131
SD EFEAESWSL VD ++ +Q+++V+KRQDV++ELMQTE+HH++TL IM +++ + +
Sbjct: 820 SSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGM 879
Query: 132 QEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQ 191
+EELQ + ++FPC D+LLE H HF +KERRQES GSDRN+VI +IGD+LVQQ
Sbjct: 880 KEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCA-GSDRNFVIDRIGDILVQQ 938
Query: 192 FSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECIL 251
FS EN +MK+ YG FC H EAV+ +K L QQNKKFQN IK + + RR G+ ECIL
Sbjct: 939 FSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQNKKFQNFIKLRNSNLLARRRGIPECIL 997
Query: 252 LVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREI 311
LVTQRITKYPVLVERI+Q T+ TE+++DL +AL LIKD+I+ VD KV+E EK Q+ EI
Sbjct: 998 LVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEI 1057
Query: 312 AGKMDLKSSSKLKNGLTFRKEDML--QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLL 369
K++ K+ +KLKNG FRK+ ++ +R L +G++ WKT +GR KDILA+LLTDVLL L
Sbjct: 1058 LNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFL 1117
Query: 370 QEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRN 429
QEKDQKY+FA+VD KP VISLQKLI REVANEE+ MFLISAS GPEMYEI+T+SKE+RN
Sbjct: 1118 QEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERN 1177
Query: 430 AWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQ 489
WM IQ+AVESCP+E+ G S +E+++ EAR +++ QE L+ +DQ I L EK
Sbjct: 1178 NWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKL 1237
Query: 490 QIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI-CRQLGSAN 548
IY E+ E+ G ED+ L DP E Q +L +A+ E E +Q + Q+G+ +
Sbjct: 1238 HIYAELGELSGFEDVHLEPHLLIKPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVS 1297
Query: 549 GQAEDGGSSTGPPRRAETFAGYDCTNSPTKN----GSFKKKVSSTDPRPRDWRGPPNSPD 604
ED S G A+T + +D SPT + G + S DP + D
Sbjct: 1298 QSCED---SCGDSVLADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQG-----VVTD 1349
Query: 605 LKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQD 664
L +SD+ E + PG+ +SE++Q IQ L++LL +LQA + QD
Sbjct: 1350 LAVSDAG------EKVECRNFPGSS---------QSEIIQAIQNLTRLLYSLQAALTIQD 1394
Query: 665 SYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRW 724
S++E R +Q++E S L+ ++ R+ ++Q EE A + +LQ QL+ EQ+RW
Sbjct: 1395 SHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANVHQLQHQLQQEQRRW 1454
Query: 725 ERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAV 784
R + Q + + LQERE E + E L + R EL+ Q Q YQH LERLRE QR V
Sbjct: 1455 LRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEYQHSLERLREGQRLV 1514
Query: 785 ERERERLELLRRL------KKQNTAPGALPP 809
ERE+ R+ + L +Q + P L P
Sbjct: 1515 EREQARMRAQQSLLGHWKHGRQRSLPAVLLP 1545
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 30 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 82
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 1920 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 1979
Query: 83 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 142
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 1980 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 2039
Query: 143 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 202
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 2040 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 2099
Query: 203 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 262
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 2100 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 2159
Query: 263 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 322
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 2160 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 2219
Query: 323 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 382
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 2220 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 2279
Query: 383 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 442
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 2280 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339
Query: 443 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 501
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 2340 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 2394
Query: 502 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 551
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 2395 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 2453
Query: 552 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 608
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 2454 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 2500
Query: 609 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 668
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 2501 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 2551
Query: 669 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 728
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 2552 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 2609
Query: 729 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 788
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 2610 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 2669
Query: 789 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 847
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 2670 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 2715
Query: 848 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 897
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 2716 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 2775
Query: 898 ----------KGGKDKGGKSRGSQRWESSAS 918
K K K K+ SQ + AS
Sbjct: 2776 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 2806
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 30 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 82
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 161 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 220
Query: 83 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 142
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 221 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 280
Query: 143 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 202
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 281 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 340
Query: 203 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 262
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 341 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 400
Query: 263 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 322
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 401 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 460
Query: 323 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 382
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 461 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 520
Query: 383 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 442
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 521 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580
Query: 443 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 501
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 581 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 635
Query: 502 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 551
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 636 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 694
Query: 552 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 608
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 695 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 741
Query: 609 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 668
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 742 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 792
Query: 669 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 728
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 793 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 850
Query: 729 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 788
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 851 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 910
Query: 789 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 847
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 911 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 956
Query: 848 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 897
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 957 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 1016
Query: 898 ----------KGGKDKGGKSRGSQRWESSAS 918
K K K K+ SQ + AS
Sbjct: 1017 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 1047
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 30 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 82
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 1916 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 1975
Query: 83 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 142
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 1976 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 2035
Query: 143 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 202
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 2036 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 2095
Query: 203 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 262
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 2096 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 2155
Query: 263 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 322
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 2156 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 2215
Query: 323 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 382
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 2216 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 2275
Query: 383 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 442
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 2276 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335
Query: 443 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 501
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 2336 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 2390
Query: 502 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 551
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 2391 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 2449
Query: 552 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 608
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 2450 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 2496
Query: 609 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 668
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 2497 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 2547
Query: 669 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 728
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 2548 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 2605
Query: 729 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 788
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 2606 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 2665
Query: 789 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 847
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 2666 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 2711
Query: 848 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 897
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 2712 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 2771
Query: 898 ----------KGGKDKGGKSRGSQRWESSAS 918
K K K K+ SQ + AS
Sbjct: 2772 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 2802
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 466 bits (1200), Expect = e-131
Identities = 291/758 (38%), Positives = 435/758 (57%), Gaps = 75/758 (9%)
Query: 30 DEADSAFLKFKQTADDSLSLTSP--NTESIFVEDPYTASLRSEIESDGHEFEAESWSLAV 87
DE+ + + DSL++ + + ES+ E+ + L S+ E D +F A+SWSLAV
Sbjct: 161 DESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADSWSLAV 220
Query: 88 DAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFP 147
D+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL + LFP
Sbjct: 221 DSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFP 280
Query: 148 CADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVF 207
C D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M + Y F
Sbjct: 281 CVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEF 340
Query: 208 CSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERI 267
CS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+L+ RI
Sbjct: 341 CSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRI 400
Query: 268 IQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL 327
+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ + +
Sbjct: 401 LQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKG 460
Query: 328 TFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPV 387
F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D KP V
Sbjct: 461 PFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSV 519
Query: 388 ISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEE 447
+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +CP E+
Sbjct: 520 VSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTCPSRED 577
Query: 448 GPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLED---- 503
P E+E LR + L KD+ + + L EK ++ EM ED
Sbjct: 578 FPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSG 629
Query: 504 --LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSANGQAE 552
LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 630 MALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEP 688
Query: 553 DGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDI 612
D G +T P A + T NGS + + +D RD
Sbjct: 689 DSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN--------------- 726
Query: 613 PGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQ-R 671
G+ SPQ E +QR+ L LL LQA +A QD+ +E +
Sbjct: 727 -GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFP 767
Query: 672 AAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQ 731
+ REK R S G EKQ E A L++ + L+ E +R R + +
Sbjct: 768 EGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEER 827
Query: 732 HQELERAGARLQEREGEARQLRERLEQERAELERQRQA 769
E ARL+E E Q R LE+E E RQ A
Sbjct: 828 ATEAGSLEARLRESE----QARALLEREAEEARRQLAA 861
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 466 bits (1200), Expect = e-131
Identities = 291/758 (38%), Positives = 435/758 (57%), Gaps = 75/758 (9%)
Query: 30 DEADSAFLKFKQTADDSLSLTSP--NTESIFVEDPYTASLRSEIESDGHEFEAESWSLAV 87
DE+ + + DSL++ + + ES+ E+ + L S+ E D +F A+SWSLAV
Sbjct: 134 DESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADSWSLAV 193
Query: 88 DAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFP 147
D+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL + LFP
Sbjct: 194 DSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFP 253
Query: 148 CADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVF 207
C D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M + Y F
Sbjct: 254 CVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEF 313
Query: 208 CSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERI 267
CS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+L+ RI
Sbjct: 314 CSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRI 373
Query: 268 IQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL 327
+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ + +
Sbjct: 374 LQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKG 433
Query: 328 TFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPV 387
F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D KP V
Sbjct: 434 PFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSV 492
Query: 388 ISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEE 447
+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +CP E+
Sbjct: 493 VSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTCPSRED 550
Query: 448 GPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLED---- 503
P E+E LR + L KD+ + + L EK ++ EM ED
Sbjct: 551 FPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSG 602
Query: 504 --LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSANGQAE 552
LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 603 MALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEP 661
Query: 553 DGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDI 612
D G +T P A + T NGS + + +D RD
Sbjct: 662 DSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN--------------- 699
Query: 613 PGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQ-R 671
G+ SPQ E +QR+ L LL LQA +A QD+ +E +
Sbjct: 700 -GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFP 740
Query: 672 AAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQ 731
+ REK R S G EKQ E A L++ + L+ E +R R + +
Sbjct: 741 EGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEER 800
Query: 732 HQELERAGARLQEREGEARQLRERLEQERAELERQRQA 769
E ARL+E E Q R LE+E E RQ A
Sbjct: 801 ATEAGSLEARLRESE----QARALLEREAEEARRQLAA 834
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 462 bits (1188), Expect = e-130
Identities = 291/759 (38%), Positives = 435/759 (57%), Gaps = 76/759 (10%)
Query: 30 DEADSAFLKFKQTADDSLSLTSP--NTESIFVE-DPYTASLRSEIESDGHEFEAESWSLA 86
DE+ + + DSL++ + + ES+ E + + L S+ E D +F A+SWSLA
Sbjct: 161 DESPLGLRRILSQSTDSLNMRNRTLSVESLIDEAEVIYSELMSDFEMDEKDFAADSWSLA 220
Query: 87 VDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLF 146
VD+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL + LF
Sbjct: 221 VDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLF 280
Query: 147 PCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGV 206
PC D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M + Y
Sbjct: 281 PCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSE 340
Query: 207 FCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVER 266
FCS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+L+ R
Sbjct: 341 FCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISR 400
Query: 267 IIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNG 326
I+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ + +
Sbjct: 401 ILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGK 460
Query: 327 LTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPP 386
F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D KP
Sbjct: 461 GPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPS 519
Query: 387 VISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEE 446
V+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +CP E
Sbjct: 520 VVSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTCPSRE 577
Query: 447 EGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLED--- 503
+ P E+E LR + L KD+ + + L EK ++ EM ED
Sbjct: 578 DFPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGS 629
Query: 504 ---LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSANGQA 551
LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 630 GMALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE 688
Query: 552 EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSD 611
D G +T P A + T NGS + + +D RD
Sbjct: 689 PDSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN-------------- 727
Query: 612 IPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQ- 670
G+ SPQ E +QR+ L LL LQA +A QD+ +E +
Sbjct: 728 --GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLMEARF 767
Query: 671 RAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQW 730
+ REK R S G EKQ E A L++ + L+ E +R R +
Sbjct: 768 PEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEE 827
Query: 731 QHQELERAGARLQEREGEARQLRERLEQERAELERQRQA 769
+ E ARL+E E Q R LE+E E RQ A
Sbjct: 828 RATEAGSLEARLRESE----QARALLEREAEEARRQLAA 862
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 189 bits (480), Expect = 1e-47
Identities = 111/379 (29%), Positives = 208/379 (54%), Gaps = 22/379 (5%)
Query: 77 EFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQ 136
E +A++W V + + RQ+V+ EL TE H+RTL+++ ++ + +++E
Sbjct: 750 EPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENL 809
Query: 137 FSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGEN 196
+ + RLFP +L+E H+ + +K+ R+E +I++I DL++ +F G
Sbjct: 810 MPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKEISDLMLARFDGPA 861
Query: 197 GERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQR 256
E +++ FCS + A+ K ++ +FQ +++ + RRL +++ I+ QR
Sbjct: 862 REELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQR 921
Query: 257 ITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMD 316
+TKYP+L+E II++TE GT ++E L +A + ++I+ V+ V + E RL ++D
Sbjct: 922 LTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLD 981
Query: 317 LKSSSKLKNGLT--FRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQ 374
+ + N L F+ D+ R++ EG L W+ + + D+ +LL D+L+LLQ++D+
Sbjct: 982 ATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDE 1041
Query: 375 KYVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISASLQG-PEMYEIYT 422
K + S DSK PV+ L +++R VA +++A F+I S G P++YE+
Sbjct: 1042 KLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVA 1101
Query: 423 SSKEDRNAWMAHIQRAVES 441
+ D+N WM ++ AV +
Sbjct: 1102 LTSSDKNTWMELLEEAVRN 1120
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 189 bits (480), Expect = 1e-47
Identities = 111/379 (29%), Positives = 208/379 (54%), Gaps = 22/379 (5%)
Query: 77 EFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQ 136
E +A++W V + + RQ+V+ EL TE H+RTL+++ ++ + +++E
Sbjct: 710 EPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENL 769
Query: 137 FSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGEN 196
+ + RLFP +L+E H+ + +K+ R+E +I++I DL++ +F G
Sbjct: 770 MPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKEISDLMLARFDGPA 821
Query: 197 GERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQR 256
E +++ FCS + A+ K ++ +FQ +++ + RRL +++ I+ QR
Sbjct: 822 REELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQR 881
Query: 257 ITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMD 316
+TKYP+L+E II++TE GT ++E L +A + ++I+ V+ V + E RL ++D
Sbjct: 882 LTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLD 941
Query: 317 LKSSSKLKNGLT--FRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQ 374
+ + N L F+ D+ R++ EG L W+ + + D+ +LL D+L+LLQ++D+
Sbjct: 942 ATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDE 1001
Query: 375 KYVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISASLQG-PEMYEIYT 422
K + S DSK PV+ L +++R VA +++A F+I S G P++YE+
Sbjct: 1002 KLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVA 1061
Query: 423 SSKEDRNAWMAHIQRAVES 441
+ D+N WM ++ AV +
Sbjct: 1062 LTSSDKNTWMELLEEAVRN 1080
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 183 bits (464), Expect = 8e-46
Identities = 127/429 (29%), Positives = 219/429 (51%), Gaps = 29/429 (6%)
Query: 70 EIESDGHEFEAE------SWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIM 123
E +S+ +FE + +W V K +KRQ+V+ EL TE HVRTLK++
Sbjct: 750 ESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVL 809
Query: 124 LKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQK 183
+V+ + + E S + ++F +D+L+ H ++K R+ + VI +
Sbjct: 810 DQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRN------ETSVIDQ 863
Query: 184 IGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRR 243
IG+ L+ FSG E++K FCS A+ K +++ +FQ ++ + + RR
Sbjct: 864 IGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRR 923
Query: 244 LGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECE 303
L +++ I QR+TKYP+L++ I + TE TE E + +A + + I++ V+ V E E
Sbjct: 924 LQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTE-REKVKKAADHCRQILNYVNQAVKEAE 982
Query: 304 KGQRLREIAGKMDLKS--SSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAIL 361
QRL + ++D S S+ N R D+ +R++ EG L WK + D+ +L
Sbjct: 983 NKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLL 1042
Query: 362 LTDVLLLLQEKDQKYVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISA 410
L D+L+LLQ++D + V ++ DSK PVI L ++VR+VA + KA+F+IS
Sbjct: 1043 LEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISM 1102
Query: 411 SLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEE---ERKVVEARATRL 467
S G ++YE+ + ++ W I R S ++ P LP+ E E ++L
Sbjct: 1103 SDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKL 1162
Query: 468 RDFQERLSM 476
++ Q +S+
Sbjct: 1163 KEEQHGISV 1171
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 177 bits (450), Expect = 3e-44
Identities = 155/545 (28%), Positives = 250/545 (45%), Gaps = 56/545 (10%)
Query: 45 DSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKREVVK 101
+SL+ E E P E G E E E W V + VK
Sbjct: 373 ESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVK 431
Query: 102 RQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLA 161
RQ+V+ EL+ TE HVR L+++ ++ + + E L F + + +FP D+L+E HS FL
Sbjct: 432 RQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLD 491
Query: 162 RLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLL 221
RL +RRQES Y+I++IGD+L+ +F G G ++ FCS + A+ K
Sbjct: 492 RLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAK 544
Query: 222 LQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDL 281
+++ +F +++ + RRL +++ I QR+TKYP+L++ I QNTE TE E +
Sbjct: 545 QRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-REKV 603
Query: 282 TQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQRQL 339
A ++I+ V+ V + E RL++ ++DL + + + F+ D+ +++L
Sbjct: 604 ELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKL 663
Query: 340 HLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP---PVI 388
EG L W+ T + ++ +LL D+LLLLQ +D++ + S D K PV+
Sbjct: 664 VHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVL 723
Query: 389 SLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR--------AVE 440
L + REVA + KA +++ Q ++YE+ + +R W A I A
Sbjct: 724 RLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPA 783
Query: 441 SCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIAQSL 485
S P P S E E +AR R L D R + QL A +L
Sbjct: 784 SRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATAL 843
Query: 486 ---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIEGIQ 537
L +Q+ E G G+ GG S E + L L+ M ++E ++
Sbjct: 844 RKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELE 903
Query: 538 SLICR 542
CR
Sbjct: 904 EEFCR 908
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 177 bits (450), Expect = 3e-44
Identities = 155/545 (28%), Positives = 250/545 (45%), Gaps = 56/545 (10%)
Query: 45 DSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKREVVK 101
+SL+ E E P E G E E E W V + VK
Sbjct: 325 ESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVK 383
Query: 102 RQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLA 161
RQ+V+ EL+ TE HVR L+++ ++ + + E L F + + +FP D+L+E HS FL
Sbjct: 384 RQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLD 443
Query: 162 RLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLL 221
RL +RRQES Y+I++IGD+L+ +F G G ++ FCS + A+ K
Sbjct: 444 RLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAK 496
Query: 222 LQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDL 281
+++ +F +++ + RRL +++ I QR+TKYP+L++ I QNTE TE E +
Sbjct: 497 QRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-REKV 555
Query: 282 TQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQRQL 339
A ++I+ V+ V + E RL++ ++DL + + + F+ D+ +++L
Sbjct: 556 ELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKL 615
Query: 340 HLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP---PVI 388
EG L W+ T + ++ +LL D+LLLLQ +D++ + S D K PV+
Sbjct: 616 VHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVL 675
Query: 389 SLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR--------AVE 440
L + REVA + KA +++ Q ++YE+ + +R W A I A
Sbjct: 676 RLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPA 735
Query: 441 SCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIAQSL 485
S P P S E E +AR R L D R + QL A +L
Sbjct: 736 SRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATAL 795
Query: 486 ---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIEGIQ 537
L +Q+ E G G+ GG S E + L L+ M ++E ++
Sbjct: 796 RKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELE 855
Query: 538 SLICR 542
CR
Sbjct: 856 EEFCR 860
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 177 bits (450), Expect = 3e-44
Identities = 155/545 (28%), Positives = 250/545 (45%), Gaps = 56/545 (10%)
Query: 45 DSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKREVVK 101
+SL+ E E P E G E E E W V + VK
Sbjct: 358 ESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVK 416
Query: 102 RQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLA 161
RQ+V+ EL+ TE HVR L+++ ++ + + E L F + + +FP D+L+E HS FL
Sbjct: 417 RQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLD 476
Query: 162 RLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLL 221
RL +RRQES Y+I++IGD+L+ +F G G ++ FCS + A+ K
Sbjct: 477 RLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAK 529
Query: 222 LQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDL 281
+++ +F +++ + RRL +++ I QR+TKYP+L++ I QNTE TE E +
Sbjct: 530 QRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-REKV 588
Query: 282 TQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQRQL 339
A ++I+ V+ V + E RL++ ++DL + + + F+ D+ +++L
Sbjct: 589 ELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKL 648
Query: 340 HLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP---PVI 388
EG L W+ T + ++ +LL D+LLLLQ +D++ + S D K PV+
Sbjct: 649 VHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVL 708
Query: 389 SLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR--------AVE 440
L + REVA + KA +++ Q ++YE+ + +R W A I A
Sbjct: 709 RLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPA 768
Query: 441 SCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIAQSL 485
S P P S E E +AR R L D R + QL A +L
Sbjct: 769 SRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATAL 828
Query: 486 ---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIEGIQ 537
L +Q+ E G G+ GG S E + L L+ M ++E ++
Sbjct: 829 RKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELE 888
Query: 538 SLICR 542
CR
Sbjct: 889 EEFCR 893
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 91.7 bits (226), Expect = 3e-18
Identities = 92/382 (24%), Positives = 177/382 (46%), Gaps = 42/382 (10%)
Query: 101 KRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFL 160
KRQ ++EL+QTE ++ L+++++V+ + + E + + +F +L+ +++ L
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1241
Query: 161 ARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKL 220
L+ R++ E+ +Q IGD+L + S + Y FCS + +
Sbjct: 1242 KALRVRKKTGGEK-----MPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQ 1290
Query: 221 LLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYED 280
++ F+ +KK+ + + + + +L QRIT+YP+L+ I++NT D+
Sbjct: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
Query: 281 LTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK--LKNGLTFRKEDMLQRQ 338
L AL +++ SQV+ V E E RL I + + ++ + N LT + R+
Sbjct: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT---NCLGPRK 1407
Query: 339 LHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQ-------KYVFASVDS------KP 385
L G L +KT S K++ L D LLL Q + +F+S + K
Sbjct: 1408 LLHSGKL-YKTKSN--KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKT 1464
Query: 386 PVISLQKLI-VREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPD 444
P+ + L+ + + ++ +F IS +Y + T + +R AW+ I+ A E D
Sbjct: 1465 PIFLNEVLVKLPTDPSSDEPVFHIS---HIDRVYTLRTDNINERTAWVQKIKAASEQYID 1521
Query: 445 EEEGPFSLPEEERKVVEARATR 466
E+ ++ K +AR+ +
Sbjct: 1522 TEK------KKREKAYQARSQK 1537
Score = 61.2 bits (147), Expect = 5e-09
Identities = 51/130 (39%), Positives = 79/130 (60%), Gaps = 14/130 (10%)
Query: 674 IQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRW-ERERQWQH 732
+QE E Q +L T E +R+ N+E+ E LEK + L +QQR ER+ Q +
Sbjct: 350 MQEEEPQKKLPVT-----FEDKRKANYERGNME---LEKRRQALMEQQQREAERKAQKEK 401
Query: 733 QELERAGARLQEREGEAR-QLRERLEQERAELERQRQAYQH-DLERLREAQRAVERERER 790
+E ER LQE+E + + +L +RLE++R ELERQR+ + D+ER A++ +ER+R R
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQR-ELERQREEERRKDIERREAAKQELERQR-R 459
Query: 791 LELLRRLKKQ 800
LE R+++Q
Sbjct: 460 LE-WERIRRQ 468
Score = 43.1 bits (100), Expect = 0.001
Identities = 52/187 (27%), Positives = 81/187 (43%), Gaps = 21/187 (11%)
Query: 617 EESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQE 676
EE PQ + P T D R + ++ Q L+ Q A + + E + ++
Sbjct: 352 EEEPQK-KLPVTFEDKRKANYERGNM--ELEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
Query: 677 REKQFRLQSTRGNLLLEQERQRNFEKQREER---------AALEKLQSQLRHEQQRWERE 727
RE Q + + L E+QR E+QREE AA ++L+ Q R E WER
Sbjct: 409 RELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE---WERI 465
Query: 728 RQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERE 787
R+ QEL R QE E +L + + ELE +Q RL++ + + +
Sbjct: 466 RR---QELLNQKNREQE---EIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQ 519
Query: 788 RERLELL 794
+ LE+L
Sbjct: 520 KTELEVL 526
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/126 (23%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
Query: 667 VETQRAAIQEREKQFRLQSTRGNLLLEQ-ERQRNFEKQREERAALEKLQSQLRHEQQRWE 725
+E QR ++RE++ R R ++ ERQR E +R R L +++ + E R
Sbjct: 426 LEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLN 485
Query: 726 RERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVE 785
+++ H ELE + Q+ G + +R + + ++ ELE + ++ +++ Q+ ++
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQ 545
Query: 786 RERERL 791
+ +L
Sbjct: 546 EYQNKL 551
Score = 32.3 bits (72), Expect = 2.3
Identities = 40/169 (23%), Positives = 74/169 (43%), Gaps = 30/169 (17%)
Query: 637 VLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQST--RGNLLLEQ 694
VL+ + I + QL LQ ++ Y+ ++ + ER K + +T G LL +
Sbjct: 525 VLDKQCDLEIMEIKQLQQELQEY-QNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHK 583
Query: 695 ERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRE 754
++ EK E+L +L+ + E+E ++L E + QL+E
Sbjct: 584 ---KSLEK--------EELCQRLKEQLDALEKE----------TASKLSEMDSFNNQLKE 622
Query: 755 RLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTA 803
E + Q Y+ ++L+E ER+RLEL+++ K ++ A
Sbjct: 623 LRETYNTQQLALEQLYKIKRDKLKEI------ERKRLELMQKKKLEDEA 665
Score = 31.6 bits (70), Expect = 4.0
Identities = 34/158 (21%), Positives = 75/158 (47%), Gaps = 15/158 (9%)
Query: 639 ESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLL--LEQER 696
+ EL QR L + L L+ A + S +++ ++E + + Q L +++++
Sbjct: 588 KEELCQR---LKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDK 644
Query: 697 QRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERL 756
+ E++R E +KL+ + + ++ +E W+ + L + Q+R E + +
Sbjct: 645 LKEIERKRLELMQKKKLEDEAARKAKQG-KENLWK-ENLRKEEEEKQKRLQEEKTQEKIQ 702
Query: 757 EQERAELERQRQAYQHDLERLREAQRAVERERERLELL 794
E+ER E+QR+ ++ +A E++RE +L
Sbjct: 703 EEERKAEEKQRKD--------KDTLKAEEKKRETASVL 732
Score = 30.8 bits (68), Expect = 6.8
Identities = 24/87 (27%), Positives = 32/87 (36%), Gaps = 10/87 (11%)
Query: 919 FDLKQQLLLNKLMGKD-----ESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSP 973
F + +L+ KL G+ + SP++ R P+ P P PP A P
Sbjct: 79 FSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA--P 136
Query: 974 SEGFSLKAGGTALLPGPPAPSPLPATP 1000
S GT L PP P P P
Sbjct: 137 ITSLSSATSGTNL---PPLMMPTPLVP 160
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 91.7 bits (226), Expect = 3e-18
Identities = 92/382 (24%), Positives = 177/382 (46%), Gaps = 42/382 (10%)
Query: 101 KRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFL 160
KRQ ++EL+QTE ++ L+++++V+ + + E + + +F +L+ +++ L
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1268
Query: 161 ARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKL 220
L+ R++ E+ +Q IGD+L + S + Y FCS + +
Sbjct: 1269 KALRVRKKTGGEK-----MPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQ 1317
Query: 221 LLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYED 280
++ F+ +KK+ + + + + +L QRIT+YP+L+ I++NT D+
Sbjct: 1318 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1377
Query: 281 LTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK--LKNGLTFRKEDMLQRQ 338
L AL +++ SQV+ V E E RL I + + ++ + N LT + R+
Sbjct: 1378 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT---NCLGPRK 1434
Query: 339 LHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQ-------KYVFASVDS------KP 385
L G L +KT S K++ L D LLL Q + +F+S + K
Sbjct: 1435 LLHSGKL-YKTKSN--KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKT 1491
Query: 386 PVISLQKLI-VREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPD 444
P+ + L+ + + ++ +F IS +Y + T + +R AW+ I+ A E D
Sbjct: 1492 PIFLNEVLVKLPTDPSSDEPVFHIS---HIDRVYTLRTDNINERTAWVQKIKAASEQYID 1548
Query: 445 EEEGPFSLPEEERKVVEARATR 466
E+ ++ K +AR+ +
Sbjct: 1549 TEK------KKREKAYQARSQK 1564
Score = 61.2 bits (147), Expect = 5e-09
Identities = 51/130 (39%), Positives = 79/130 (60%), Gaps = 14/130 (10%)
Query: 674 IQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRW-ERERQWQH 732
+QE E Q +L T E +R+ N+E+ E LEK + L +QQR ER+ Q +
Sbjct: 350 MQEEEPQKKLPVT-----FEDKRKANYERGNME---LEKRRQALMEQQQREAERKAQKEK 401
Query: 733 QELERAGARLQEREGEAR-QLRERLEQERAELERQRQAYQH-DLERLREAQRAVERERER 790
+E ER LQE+E + + +L +RLE++R ELERQR+ + D+ER A++ +ER+R R
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQR-ELERQREEERRKDIERREAAKQELERQR-R 459
Query: 791 LELLRRLKKQ 800
LE R+++Q
Sbjct: 460 LE-WERIRRQ 468
Score = 43.1 bits (100), Expect = 0.001
Identities = 52/187 (27%), Positives = 81/187 (43%), Gaps = 21/187 (11%)
Query: 617 EESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQE 676
EE PQ + P T D R + ++ Q L+ Q A + + E + ++
Sbjct: 352 EEEPQK-KLPVTFEDKRKANYERGNM--ELEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
Query: 677 REKQFRLQSTRGNLLLEQERQRNFEKQREE---------RAALEKLQSQLRHEQQRWERE 727
RE Q + + L E+QR E+QREE AA ++L+ Q R E WER
Sbjct: 409 RELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE---WERI 465
Query: 728 RQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERE 787
R+ QEL R QE E +L + + ELE +Q RL++ + + +
Sbjct: 466 RR---QELLNQKNREQE---EIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQ 519
Query: 788 RERLELL 794
+ LE+L
Sbjct: 520 KTELEVL 526
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/126 (23%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
Query: 667 VETQRAAIQEREKQFRLQSTRGNLLLEQ-ERQRNFEKQREERAALEKLQSQLRHEQQRWE 725
+E QR ++RE++ R R ++ ERQR E +R R L +++ + E R
Sbjct: 426 LEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLN 485
Query: 726 RERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVE 785
+++ H ELE + Q+ G + +R + + ++ ELE + ++ +++ Q+ ++
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQ 545
Query: 786 RERERL 791
+ +L
Sbjct: 546 EYQNKL 551
Score = 33.5 bits (75), Expect = 1.0
Identities = 31/157 (19%), Positives = 73/157 (46%), Gaps = 22/157 (14%)
Query: 638 LESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQ 697
++ ++Q + +L L NL ++ TQ+ A+++ K +++++
Sbjct: 625 MDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYK------------IKRDKL 672
Query: 698 RNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLE 757
+ E++R E +KL+ + + ++ +E W+ + L + Q+R E + + E
Sbjct: 673 KEIERKRLELMQKKKLEDEAARKAKQG-KENLWK-ENLRKEEEEKQKRLQEEKTQEKIQE 730
Query: 758 QERAELERQRQAYQHDLERLREAQRAVERERERLELL 794
+ER E+QR+ ++ +A E++RE +L
Sbjct: 731 EERKAEEKQRKD--------KDTLKAEEKKRETASVL 759
Score = 30.8 bits (68), Expect = 6.8
Identities = 24/87 (27%), Positives = 32/87 (36%), Gaps = 10/87 (11%)
Query: 919 FDLKQQLLLNKLMGKD-----ESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSP 973
F + +L+ KL G+ + SP++ R P+ P P PP A P
Sbjct: 79 FSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA--P 136
Query: 974 SEGFSLKAGGTALLPGPPAPSPLPATP 1000
S GT L PP P P P
Sbjct: 137 ITSLSSATSGTNL---PPLMMPTPLVP 160
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)
Query: 38 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 97
+F QT S+S S + I P++ R+ S +++ WS D +
Sbjct: 68 RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 124
Query: 98 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 157
+ +KRQ+ ++EL Q E + LK+ K Y + + + + + ++F D L+ H
Sbjct: 125 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 184
Query: 158 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 217
L++L++ R+ +GS + +G +LV Y +CS A
Sbjct: 185 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 227
Query: 218 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 274
K LL +Q+ + Q+ +++ R+L + + + R+ KYP+L+ I+++T
Sbjct: 228 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 286
Query: 275 TEDYEDLTQALNLIKDIISQVDAKVSECE 303
D + L +A+N+I+ I+++++ K E E
Sbjct: 287 NPDQQHLEEAINIIQGIVAEINTKTGESE 315
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
[Homo sapiens]
Length = 558
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)
Query: 38 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 97
+F QT S+S S + I P++ R+ S +++ WS D +
Sbjct: 94 RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 150
Query: 98 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 157
+ +KRQ+ ++EL Q E + LK+ K Y + + + + + ++F D L+ H
Sbjct: 151 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 210
Query: 158 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 217
L++L++ R+ +GS + +G +LV Y +CS A
Sbjct: 211 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 253
Query: 218 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 274
K LL +Q+ + Q+ +++ R+L + + + R+ KYP+L+ I+++T
Sbjct: 254 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 312
Query: 275 TEDYEDLTQALNLIKDIISQVDAKVSECE 303
D + L +A+N+I+ I+++++ K E E
Sbjct: 313 NPDQQHLEEAINIIQGIVAEINTKTGESE 341
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)
Query: 38 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 97
+F QT S+S S + I P++ R+ S +++ WS D +
Sbjct: 62 RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 118
Query: 98 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 157
+ +KRQ+ ++EL Q E + LK+ K Y + + + + + ++F D L+ H
Sbjct: 119 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 178
Query: 158 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 217
L++L++ R+ +GS + +G +LV Y +CS A
Sbjct: 179 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 221
Query: 218 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 274
K LL +Q+ + Q+ +++ R+L + + + R+ KYP+L+ I+++T
Sbjct: 222 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 280
Query: 275 TEDYEDLTQALNLIKDIISQVDAKVSECE 303
D + L +A+N+I+ I+++++ K E E
Sbjct: 281 NPDQQHLEEAINIIQGIVAEINTKTGESE 309
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/351 (22%), Positives = 148/351 (42%), Gaps = 27/351 (7%)
Query: 101 KRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFL 160
KRQ ++EL+ TE ++V L+++ +++ + L E + K + +F +L+ + L
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296
Query: 161 ARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKL 220
L+ R++ S E+ ++ IGD+L Q + Y FCS + +
Sbjct: 1297 KALRVRKKMSGEK-----MPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQQ 1345
Query: 221 LLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYED 280
+ F+ +K++ + + + IL QR+T+YP++++ I++NT D+
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 281 LTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRK-EDMLQRQL 339
L AL +++ SQV+ V E E RL I + + L L F + L +
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEG---LSEQLVFNSVTNCLGPRK 1462
Query: 340 HLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVA 399
L +K S K++ L D LLL Q + P +LQ + +
Sbjct: 1463 FLHSGKLYKAKSN--KELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPI 1520
Query: 400 NEEKAMFLISASLQGPE----------MYEIYTSSKEDRNAWMAHIQRAVE 440
+ + + G E +Y + S +R AW+ I+ A E
Sbjct: 1521 FLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASE 1571
Score = 64.3 bits (155), Expect = 6e-10
Identities = 47/127 (37%), Positives = 73/127 (57%), Gaps = 6/127 (4%)
Query: 678 EKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQ--SQLRHEQQRWERERQWQ---H 732
E + R RGNL LE+ RQ E+QR+E+ L +L+ Q R E++R E+ER+ Q
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE 410
Query: 733 QELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLE 792
++LE+ ++RE E R+ ER E + ELERQRQ + + R +E +E+E +
Sbjct: 411 KQLEKQRELERQREEERRKEIERREAAKRELERQRQ-LEWERNRRQELLNQRNKEQEDIV 469
Query: 793 LLRRLKK 799
+L+ KK
Sbjct: 470 VLKAKKK 476
Score = 49.3 bits (116), Expect = 2e-05
Identities = 51/222 (22%), Positives = 98/222 (44%), Gaps = 40/222 (18%)
Query: 607 LSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQR-------IQTLSQLLLNLQAV 659
+S + + E P V+E + + +LP E + + ++ Q LL Q
Sbjct: 320 ISSTSVDQRLPEEP-VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQR- 377
Query: 660 IAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQ--ERQRNFEKQREE--RAALEKLQS 715
Q+ + +RA + +E++ + Q + L LE+ E+QR E+QREE R +E+ ++
Sbjct: 378 -KEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREA 436
Query: 716 QLRH-EQQR---WERERQWQ----------------------HQELERAGARLQEREGEA 749
R E+QR WER R+ + ELE + + EG+
Sbjct: 437 AKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKL 496
Query: 750 RQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERL 791
+ +R RL +R E+E ++ + + + Q+ ++ ++ L
Sbjct: 497 QDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQML 538
Score = 42.0 bits (97), Expect = 0.003
Identities = 42/162 (25%), Positives = 72/162 (44%), Gaps = 16/162 (9%)
Query: 642 LVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFE 701
L+ Q L+ L +Q H+DS V +RA K+ Q R L E
Sbjct: 541 LIPEKQILNDQLKQVQQNSLHRDSLVTLKRAL---EAKELARQHLRDQL---------DE 588
Query: 702 KQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERA 761
++E R+ L+++ Q E Q+L++ + ER + Q R+ +E E+
Sbjct: 589 VEKETRSKLQEIDI---FNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQ 645
Query: 762 ELERQRQAYQHDLERLREAQRAVERERER-LELLRRLKKQNT 802
+ E QR+A + D + L Q+ E +R R L +LK++ +
Sbjct: 646 KEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREES 687
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 66 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 355
Query: 121 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 171
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 172 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 231
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 416 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 462
Query: 232 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 291
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 463 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 521
Query: 292 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 335
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 522 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 581
Query: 336 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 395
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 582 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 638
Query: 396 REV 398
RE+
Sbjct: 639 REL 641
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 66 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 375 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 432
Query: 121 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 171
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 433 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 492
Query: 172 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 231
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 493 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 539
Query: 232 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 291
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 540 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 598
Query: 292 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 335
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 599 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 658
Query: 336 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 395
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 659 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 715
Query: 396 REV 398
RE+
Sbjct: 716 REL 718
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 66 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 355
Query: 121 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 171
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 172 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 231
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 416 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 462
Query: 232 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 291
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 463 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 521
Query: 292 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 335
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 522 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 581
Query: 336 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 395
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 582 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 638
Query: 396 REV 398
RE+
Sbjct: 639 REL 641
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 66 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 355
Query: 121 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 171
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 172 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 231
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 416 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 462
Query: 232 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 291
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 463 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 521
Query: 292 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 335
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 522 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 581
Query: 336 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 395
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 582 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 638
Query: 396 REV 398
RE+
Sbjct: 639 REL 641
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 66 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 354 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 411
Query: 121 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 171
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 412 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 471
Query: 172 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 231
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 472 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 518
Query: 232 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 291
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 519 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 577
Query: 292 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 335
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 578 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 637
Query: 336 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 395
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 638 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 694
Query: 396 REV 398
RE+
Sbjct: 695 REL 697
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 70.1 bits (170), Expect = 1e-11
Identities = 96/392 (24%), Positives = 159/392 (40%), Gaps = 67/392 (17%)
Query: 592 RPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQ 651
R R RG + + + S GS EE +V P E +P + E TL +
Sbjct: 308 RTRKKRGEKDETEYEYS-----GSEEEEEEV---PEQEGEPSSIVNVPGE-----STLRR 354
Query: 652 LLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALE 711
L LQ + + Q+ +E+Q R Q LL ERQ+ E+Q+E+R LE
Sbjct: 355 DFLRLQQENKERSEALRRQQLL---QEQQLREQEEYKRQLLA-ERQKRIEQQKEQRRRLE 410
Query: 712 KLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQ 771
EQQR ERE + Q + +R + ++R E + R + E+ER E +++ +
Sbjct: 411 --------EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 772 HDLERLREAQRAVERERERLELLRRLKKQNTA-------------PGALPPDTLAEAQPP 818
+ E +R R +E E+ LE+L++ Q A PP ++P
Sbjct: 463 REQEYIR---RQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPS 519
Query: 819 SHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTEN----RLAKSDVPIQLLS 874
H P P+ P+ E +R S ++ R+ + VP + S
Sbjct: 520 FHAPE--------PKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSES 571
Query: 875 ATN--------QFQRQAAVQQQIPTKLAASTKGGKD---KGGKSRGSQRWESSASFDLKQ 923
+N QR A Q + T + +D +G + SQ + +++ ++
Sbjct: 572 FSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEP 631
Query: 924 QLL---LNKLMGKDESTSRNRRSLSPILPGRH 952
+LL + KL+ + S S + S S PG H
Sbjct: 632 RLLWERVEKLVPRPGSGSSSGSSNSGSQPGSH 663
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 69.3 bits (168), Expect = 2e-11
Identities = 74/356 (20%), Positives = 155/356 (43%), Gaps = 24/356 (6%)
Query: 661 AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE 720
A + ++ Q+ A+Q++++Q + Q + L +Q++Q+ ++ + +++A+++ + +
Sbjct: 147 ATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQ 206
Query: 721 QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA 780
QQ+ ++++Q Q ++ Q+ + + +QL+ + + + ++Q+Q Q ++ +A
Sbjct: 207 QQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQA 266
Query: 781 QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSH--PPSFNGEGLEGPRVSMLP 838
Q +++ +++ P P L + H PP + + P P
Sbjct: 267 QPPIQQP--------PMQQPQPPPSQALPQQLQQMHHTQHHQPPP---QPQQPPVAQNQP 315
Query: 839 SGVGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQR---QAAVQQQIPTKLAA 895
S + P+ +P V++ + P ++ + P++ + A Q+ Q VQQQ A
Sbjct: 316 SQLPPQSQTQPLVSQAQALP--GQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTA 373
Query: 896 STKGGKDKGGK-SRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSP 954
G + S+ S SS S + Q + S + S P P
Sbjct: 374 QAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGP 433
Query: 955 APPPDPGFPAPSPPPADSP-----SEGFSLKAGGTALLPGPPAPSPLPATPLSAKE 1005
AP P P+PSP P+ SP + FS+ + G P P+ PA A+E
Sbjct: 434 APSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEE 489
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 68.9 bits (167), Expect = 2e-11
Identities = 77/368 (20%), Positives = 160/368 (43%), Gaps = 39/368 (10%)
Query: 87 VDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQ---FSSKAIG 143
+D + K+ E K + EL+ TE +V L ++ +V+ L EE F ++ +
Sbjct: 193 LDQHHEMKETNEQ-KLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVN 251
Query: 144 RLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEK 203
++F + HS FL E+R + E ++QK+ L +
Sbjct: 252 KIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFL-------------KM 298
Query: 204 YGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVL 263
YG + G + A+ K + ++ +F++++++I I L +Q +L QRI +Y +L
Sbjct: 299 YGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEML 358
Query: 264 VERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKL 323
++ ++ + D+ D ++L +I S ++ + + E ++L EI + +
Sbjct: 359 LKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVN 418
Query: 324 KNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDS 383
+ ++ +L+ L + TS + + + L ++LL K F+ V S
Sbjct: 419 PSNELIKEGQILK--------LAARNTSAQERYL--FLFNNMLLYCVPK-----FSLVGS 463
Query: 384 KPPV---ISLQKLIVREVANEEKAMFLISASLQGPE-MYEIYTSSKEDRNAWMAHIQRAV 439
K V + + + + E NEE + + + G E E+ SS +D+ W+ +Q +
Sbjct: 464 KFTVRTRVGIDGMKIVETQNEE---YPHTFQVSGKERTLELQASSAQDKEEWIKALQETI 520
Query: 440 ESCPDEEE 447
++ E
Sbjct: 521 DAFHQRHE 528
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 68.9 bits (167), Expect = 2e-11
Identities = 54/241 (22%), Positives = 105/241 (43%), Gaps = 21/241 (8%)
Query: 66 SLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLK 125
S RS + + + WS +D + ++RQ+ +YE+ + E + LK+ K
Sbjct: 139 SSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARK 198
Query: 126 VYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIG 185
Y + + S + + +F D + H L R+ E + + +++IG
Sbjct: 199 AYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKP--------DGTVEQIG 250
Query: 186 DLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNK---KFQNLIKKIGNFSIVR 242
+LV N Y +CS A K LL Q K + Q+ +++ R
Sbjct: 251 HILVSWLPRLNA------YRGYCSNQLAA----KALLDQKKQDPRVQDFLQRCLESPFSR 300
Query: 243 RLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSEC 302
+L + + + R+ KYP+L++ I+++T D + L A+ +I+ ++S ++ K E
Sbjct: 301 KLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGES 360
Query: 303 E 303
E
Sbjct: 361 E 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,424,127
Number of Sequences: 37866
Number of extensions: 2357794
Number of successful extensions: 38481
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 671
Number of HSP's successfully gapped in prelim test: 1467
Number of HSP's that attempted gapping in prelim test: 16457
Number of HSP's gapped (non-prelim): 13318
length of query: 1015
length of database: 18,247,518
effective HSP length: 112
effective length of query: 903
effective length of database: 14,006,526
effective search space: 12647892978
effective search space used: 12647892978
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.