Search of human proteins with 40254938

Search of human proteins with 40254938

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40254938 aarF domain containing kinase 1 isoform a [Homo
sapiens]
         (523 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40254938 aarF domain containing kinase 1 isoform a [Homo sapi...  1051   0.0  
gi|217035081 aarF domain containing kinase 1 isoform b [Homo sap...   779   0.0  
gi|41393593 aarF domain containing kinase 5 [Homo sapiens]            301   1e-81
gi|34147522 chaperone, ABC1 activity of bc1 complex like precurs...    98   2e-20
gi|27363457 aarF domain containing kinase 4 isoform a [Homo sapi...    94   4e-19
gi|217416386 aarF domain containing kinase 4 isoform b [Homo sap...    79   1e-14
gi|32261307 aarF domain containing kinase 2 [Homo sapiens]             65   2e-10
gi|145312265 endoplasmic reticulum to nucleus signalling 2 [Homo...    36   0.098
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]       35   0.17 
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]        35   0.17 
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]       35   0.17 
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]        35   0.17 
gi|4758128 doublecortin-like kinase 1 [Homo sapiens]                   34   0.29 
gi|167466233 myosin light chain kinase family, member 4 [Homo sa...    33   0.83 
gi|48314820 5-oxoprolinase (ATP-hydrolysing) [Homo sapiens]            32   1.4  
gi|146219832 myosin light chain kinase 3 [Homo sapiens]                32   1.4  
gi|126090663 zinc finger homeodomain 4 [Homo sapiens]                  31   2.4  
gi|50727002 pseudouridylate synthase 7 homolog [Homo sapiens]          31   3.2  
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...    30   4.1  
gi|118498345 AT-binding transcription factor 1 [Homo sapiens]          30   4.1  
gi|20128768 serine/threonine kinase 35 [Homo sapiens]                  30   4.1  
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...    30   4.1  
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...    30   4.1  
gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo sap...    30   5.4  
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]       30   5.4  
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]       30   5.4  
gi|9966821 ectonucleoside triphosphate diphosphohydrolase 7 [Hom...    30   5.4  
gi|38683840 CD96 antigen isoform 1 precursor [Homo sapiens]            30   7.0  
gi|5032141 CD96 antigen isoform 2 precursor [Homo sapiens]             30   7.0  
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]      30   7.0  

>gi|40254938 aarF domain containing kinase 1 isoform a [Homo
           sapiens]
          Length = 523

 Score = 1051 bits (2717), Expect = 0.0
 Identities = 523/523 (100%), Positives = 523/523 (100%)

Query: 1   MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV 60
           MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV
Sbjct: 1   MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV 60

Query: 61  PYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS 120
           PYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS
Sbjct: 61  PYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS 120

Query: 121 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP 180
           QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP
Sbjct: 121 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP 180

Query: 181 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML 240
           KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML
Sbjct: 181 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML 240

Query: 241 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF 300
           RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF
Sbjct: 241 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF 300

Query: 301 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR 360
           VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR
Sbjct: 301 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR 360

Query: 361 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL 420
           VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL
Sbjct: 361 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL 420

Query: 421 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT 480
           LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT
Sbjct: 421 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT 480

Query: 481 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL 523
           QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL
Sbjct: 481 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL 523


>gi|217035081 aarF domain containing kinase 1 isoform b [Homo
           sapiens]
          Length = 455

 Score =  779 bits (2012), Expect = 0.0
 Identities = 412/523 (78%), Positives = 429/523 (82%), Gaps = 68/523 (13%)

Query: 1   MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV 60
           MARKALKLASWTSM                           A+A + +  Y         
Sbjct: 1   MARKALKLASWTSM---------------------------ALAASGIYFY--------- 24

Query: 61  PYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS 120
              S +YL                    N    ++VG+ + A   ++  +Y ++LK    
Sbjct: 25  ---SNKYLD------------------PNDFGAVRVGRAV-ATTAVISYDYLTSLK---- 58

Query: 121 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP 180
             P  S + ++      L  +IHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP
Sbjct: 59  SVPYGSEEYLQ------LRSKIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP 112

Query: 181 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML 240
           KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML
Sbjct: 113 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML 172

Query: 241 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF 300
           RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF
Sbjct: 173 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF 232

Query: 301 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR 360
           VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR
Sbjct: 233 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR 292

Query: 361 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL 420
           VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL
Sbjct: 293 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL 352

Query: 421 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT 480
           LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT
Sbjct: 353 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT 412

Query: 481 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL 523
           QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL
Sbjct: 413 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL 455


>gi|41393593 aarF domain containing kinase 5 [Homo sapiens]
          Length = 580

 Score =  301 bits (771), Expect = 1e-81
 Identities = 192/496 (38%), Positives = 279/496 (56%), Gaps = 35/496 (7%)

Query: 35  GAVRVGRAVATTAVISYDYLTSLKSVPYGSEE----YLQLRSKVHLRSARRLCELCCANR 90
           G  R GR++     IS DY      V  G EE    YL++ S  H R+A  L     +N 
Sbjct: 83  GMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNG 142

Query: 91  GTFIKVGQHLGALDYLLPEEYTSTLKVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFD 150
           G ++K+GQ L + ++LLP EYT TL+VL  +A +   QE+ ++  ED     H+LFQ FD
Sbjct: 143 GLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFD 202

Query: 151 DTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFM 210
             P+  ASLAQVH+A LHDG +VAVKVQ+  +R +   DI  +E+L+  V+ + P F F 
Sbjct: 203 YQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFS 262

Query: 211 WLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQ 270
           W++ + K  L  ELDF NEGRNAE+ ++ L HF ++ VPR+HWD S++RVL  +F  G +
Sbjct: 263 WVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCK 322

Query: 271 VNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLL 330
           VND + +    + V++I+  L K ++E IF  GF+H DPHPGNVLVRK P  GKAE+VLL
Sbjct: 323 VNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGP-DGKAELVLL 381

Query: 331 DHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARS----- 385
           DHGLYQ L E+ R   C LW+++I  D   ++ ++  LG  D Y LFA ML  R      
Sbjct: 382 DHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQD-YLLFAEMLMQRPVRLGQ 440

Query: 386 -WDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAA 444
            W S    +S+       D+     A      +  +L  +PR MLL+L+  + +R I  A
Sbjct: 441 LWGS--HLLSREEAAYMVDM-----ARERFEAVMAVLRELPRPMLLVLRNINTVRAINVA 493

Query: 445 LGTRASASSFLNMSRCCIR-----ALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELI 499
           LG  A    +  M++  +R     A A ++     S  R  ++       +W++   E+ 
Sbjct: 494 LG--APVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKV-------VWEMLKFEVA 544

Query: 500 LRVKGLKLADRVLALI 515
           LR++   LA R+ AL+
Sbjct: 545 LRLE--TLAMRLTALL 558


>gi|34147522 chaperone, ABC1 activity of bc1 complex like precursor
           [Homo sapiens]
          Length = 647

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 88/336 (26%), Positives = 150/336 (44%), Gaps = 21/336 (6%)

Query: 33  DFGAVRVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKVHLRSARRLCELCCANRGT 92
           +FG + VG      A ++   L S    P G +  L     +   +A R+    C  RG 
Sbjct: 216 NFGGLAVGLGFGALAEVAKKSLRS--EDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGA 273

Query: 93  FIKVGQHLGALDYLLPEEYTSTL-KVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDD 151
            +K+GQ L   D      + + + + +   A    ++++ + +  DLG    D  + F++
Sbjct: 274 ALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEE 333

Query: 152 TPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDI-LLMEVLVLA---VKQLFPEF 207
            P   AS+ QVH A +  GR VA+K+Q+P V    + D+  LM VL ++    + LFPE 
Sbjct: 334 RPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEH 393

Query: 208 EFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVD 267
               L+D  ++ L LE D+  E   A K   +L+   F  VP I  +L +  VL  E V 
Sbjct: 394 ----LIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVS 449

Query: 268 GGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEI 327
           G  ++  + + +     NEI  ++  +    +F   F+  DP+  N          + ++
Sbjct: 450 GFPLDQAEGLSQE--IRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQ----QHKV 503

Query: 328 VLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKE 363
            LLD G     T E+  ++  L+  +I     R +E
Sbjct: 504 ALLDFG----ATREYDRSFTDLYIQIIRAAADRDRE 535


>gi|27363457 aarF domain containing kinase 4 isoform a [Homo
           sapiens]
          Length = 544

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 97/347 (27%), Positives = 154/347 (44%), Gaps = 28/347 (8%)

Query: 33  DFGAVRVGRAVATTAVISYDYLTSLKSVPYG---SEEYLQLRSKVHLR--SARRLCELCC 87
           +FG + VG  +   A ++       KS+P G   SE    L S   L   +A R+ +  C
Sbjct: 94  NFGGLAVGLGLGVLAEMAK------KSMPGGRLQSEGGSGLDSSPFLSEANAERIVQTLC 147

Query: 88  ANRGTFIKVGQHLGALD--YLLPEEYTSTLKVLHSQAPQSSMQEIRQVIREDLGKEIHDL 145
             RG  +KVGQ L   D  ++ P+      +V  S       Q +R V+ E+LG++    
Sbjct: 148 TVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMPRWQMLR-VLEEELGRDWQAK 206

Query: 146 FQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDIL-LMEVLVLAV---K 201
             S ++ P   AS+ QVH+ +L DG  VAVK+Q+P +      D+  L+ VL ++     
Sbjct: 207 VASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPA 266

Query: 202 QLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVL 261
            LF E     L  E    L  E D+  E   A+   Q+L +  F +VP +  +L T RVL
Sbjct: 267 GLFAEQSLQALQQE----LAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVL 322

Query: 262 LMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPG 321
            ME   G  ++    + ++    N+I   L  +    +F   F+  DP+  N L      
Sbjct: 323 GMELAGGVPLDQCQGLSQDL--RNQICFQLLTLCLRELFEFRFMQTDPNWANFLY----D 376

Query: 322 TGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRL 368
               ++ LLD G  +    EF  +Y  + ++    D   V + S+ L
Sbjct: 377 ASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDL 423


>gi|217416386 aarF domain containing kinase 4 isoform b [Homo
           sapiens]
          Length = 503

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 67/244 (27%), Positives = 112/244 (45%), Gaps = 14/244 (5%)

Query: 129 EIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSK 188
           ++ +V+ E+LG++      S ++ P   AS+ QVH+ +L DG  VAVK+Q+P +      
Sbjct: 149 QMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQS 208

Query: 189 DIL-LMEVLVLAV---KQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFD 244
           D+  L+ VL ++      LF E     L  E    L  E D+  E   A+   Q+L +  
Sbjct: 209 DVQNLLAVLKMSAALPAGLFAEQSLQALQQE----LAWECDYRREAACAQNFRQLLANDP 264

Query: 245 FLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGF 304
           F +VP +  +L T RVL ME   G  ++    + ++    N+I   L  +    +F   F
Sbjct: 265 FFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDL--RNQICFQLLTLCLRELFEFRF 322

Query: 305 VHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEY 364
           +  DP+  N L          ++ LLD G  +    EF  +Y  + ++    D   V + 
Sbjct: 323 MQTDPNWANFLY----DASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQK 378

Query: 365 SQRL 368
           S+ L
Sbjct: 379 SRDL 382


>gi|32261307 aarF domain containing kinase 2 [Homo sapiens]
          Length = 626

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 6/159 (3%)

Query: 172 TVAVKVQHPKVRAQSSKDILLMEV--LVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNE 229
           +VAVKV HP + AQ   D+LLM++   VL V           +V+E +K +  ++D   E
Sbjct: 307 SVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYE 366

Query: 230 GRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERN-KIDVNEIS 288
            +N E      R+   +K P       T  VL+  + +   V+   Y +    +D+    
Sbjct: 367 AQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVSS--YQQAGIPVDLKRKI 424

Query: 289 RHLG-KMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAE 326
             LG  M  +MIFV+ FVH D HPGN+LV+   G   ++
Sbjct: 425 ARLGINMLLKMIFVDNFVHADLHPGNILVQGANGLSSSQ 463



 Score = 32.7 bits (73), Expect = 0.83
 Identities = 18/74 (24%), Positives = 33/74 (44%)

Query: 92  TFIKVGQHLGALDYLLPEEYTSTLKVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDD 151
           T+IK+GQ       L  E + +    LH +          + +R+  G +   +    + 
Sbjct: 144 TYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENR 203

Query: 152 TPLGTASLAQVHKA 165
            P+G+  +AQV+KA
Sbjct: 204 EPVGSGCVAQVYKA 217


>gi|145312265 endoplasmic reticulum to nucleus signalling 2 [Homo
           sapiens]
          Length = 974

 Score = 35.8 bits (81), Expect = 0.098
 Identities = 30/109 (27%), Positives = 53/109 (48%), Gaps = 8/109 (7%)

Query: 231 RNAEKVSQMLRHFDFLKVPRIHW-DLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISR 289
           + +++   +LR+F   + P+ H+  L   R  L E+V+   + DR  +E   + + ++  
Sbjct: 614 QESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDL-DRGGLEPEVV-LQQLMS 671

Query: 290 HLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQML 338
            L  ++S  I     VH D  PGN+L+      G   +VL D GL + L
Sbjct: 672 GLAHLHSLHI-----VHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKL 715


>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
          Length = 1863

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 5/81 (6%)

Query: 260  VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYS--EMIFVNGFVHCDPHPGNVLVR 317
            V+++E V GG++ +R   E  ++   E  +++ ++    E I   G VH D  P N++  
Sbjct: 1535 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1594

Query: 318  KHPGTGKAEIVLLDHGLYQML 338
               GT    I L+D GL + L
Sbjct: 1595 NKTGT---RIKLIDFGLARRL 1612


>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
          Length = 1914

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 5/81 (6%)

Query: 260  VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYS--EMIFVNGFVHCDPHPGNVLVR 317
            V+++E V GG++ +R   E  ++   E  +++ ++    E I   G VH D  P N++  
Sbjct: 1535 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1594

Query: 318  KHPGTGKAEIVLLDHGLYQML 338
               GT    I L+D GL + L
Sbjct: 1595 NKTGT---RIKLIDFGLARRL 1612


>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
          Length = 1794

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 5/81 (6%)

Query: 260  VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYS--EMIFVNGFVHCDPHPGNVLVR 317
            V+++E V GG++ +R   E  ++   E  +++ ++    E I   G VH D  P N++  
Sbjct: 1466 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1525

Query: 318  KHPGTGKAEIVLLDHGLYQML 338
               GT    I L+D GL + L
Sbjct: 1526 NKTGT---RIKLIDFGLARRL 1543


>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
          Length = 1845

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 5/81 (6%)

Query: 260  VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYS--EMIFVNGFVHCDPHPGNVLVR 317
            V+++E V GG++ +R   E  ++   E  +++ ++    E I   G VH D  P N++  
Sbjct: 1466 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1525

Query: 318  KHPGTGKAEIVLLDHGLYQML 338
               GT    I L+D GL + L
Sbjct: 1526 NKTGT---RIKLIDFGLARRL 1543


>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
          Length = 729

 Score = 34.3 bits (77), Expect = 0.29
 Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 4/83 (4%)

Query: 254 DLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVN--GFVHCDPHP 311
           D+ TE  L+ME V GG + D      NK    + S  L  + S + +++    VH D  P
Sbjct: 456 DVPTELYLVMELVKGGDLFDA-ITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 514

Query: 312 GNVLVRKHPGTGKAEIVLLDHGL 334
            N+LV +H   G   + L D GL
Sbjct: 515 ENLLVYEHQ-DGSKSLKLGDFGL 536


>gi|167466233 myosin light chain kinase family, member 4 [Homo
           sapiens]
          Length = 388

 Score = 32.7 bits (73), Expect = 0.83
 Identities = 32/130 (24%), Positives = 58/130 (44%), Gaps = 24/130 (18%)

Query: 229 EGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKI------ 282
           E +N   V   L H + +++    ++   + VL+ME+VDGG++ DR   E   +      
Sbjct: 147 EVKNEISVMNQLDHANLIQLYDA-FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTI 205

Query: 283 ----DVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQML 338
                + E  RH+ +MY         +H D  P N+L          +I ++D GL +  
Sbjct: 206 LFMKQICEGIRHMHQMY--------ILHLDLKPENILCVNRDA---KQIKIIDFGLARRY 254

Query: 339 --TEEFRLNY 346
              E+ ++N+
Sbjct: 255 KPREKLKVNF 264


>gi|48314820 5-oxoprolinase (ATP-hydrolysing) [Homo sapiens]
          Length = 1288

 Score = 32.0 bits (71), Expect = 1.4
 Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 10/61 (16%)

Query: 267 DGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAE 326
           DGG V++  +          I  HLG M   + F    +  D HPG+VL+  HP  G + 
Sbjct: 779 DGGLVSNAPH----------IPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSH 828

Query: 327 I 327
           +
Sbjct: 829 L 829


>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
          Length = 819

 Score = 32.0 bits (71), Expect = 1.4
 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 13/93 (13%)

Query: 261 LLMEFVDGGQVNDRDYMER---NKIDVNEISRHL--GKMYSEMIFVNGFVHCDPHPGNVL 315
           L+ME+VDGG++ DR   E+    ++DV   +R +  G  Y    ++   +H D  P N+L
Sbjct: 587 LVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI---LHLDLKPENIL 643

Query: 316 VRKHPGTGKAEIVLLDHGLYQML--TEEFRLNY 346
                G    +I ++D GL +     E+ ++N+
Sbjct: 644 CVNQTG---HQIKIIDFGLARRYKPREKLKVNF 673


>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
          Length = 3571

 Score = 31.2 bits (69), Expect = 2.4
 Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 51   YDYLTSLKSVPYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEE 110
            Y Y  +  S+ + + + LQ+ S+ H   A  +C LC  +  TF  + +HL A     PE 
Sbjct: 1350 YKYRCNHCSLAFKTMQKLQIHSQYHAIRAATMCNLCQRSFRTFQALKKHLEAGH---PEL 1406

Query: 111  YTSTLKVLHSQAP 123
              + L+ L++  P
Sbjct: 1407 SEAELQQLYASLP 1419


>gi|50727002 pseudouridylate synthase 7 homolog [Homo sapiens]
          Length = 661

 Score = 30.8 bits (68), Expect = 3.2
 Identities = 14/33 (42%), Positives = 21/33 (63%), Gaps = 2/33 (6%)

Query: 343 RLNYCHLWQSLIWTDM--KRVKEYSQRLGAGDL 373
           RL Y H +QS +W +M  KR+++Y  +   GDL
Sbjct: 472 RLMYIHSYQSYVWNNMVSKRIEDYGLKPVPGDL 504


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score = 30.4 bits (67), Expect = 4.1
 Identities = 30/127 (23%), Positives = 60/127 (47%), Gaps = 10/127 (7%)

Query: 224 LDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKID 283
           LD + + +   +  ++ RH   +K+ ++     T+  ++ME+V GG++ D    +  +++
Sbjct: 55  LDVVGKIKREIQNLKLFRHPHIIKLYQVI-STPTDFFMVMEYVSGGELFDY-ICKHGRVE 112

Query: 284 VNEISRHLGKMYSEMIFVNG--FVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTE- 340
             E  R   ++ S + + +    VH D  P NVL+  H         + D GL  M+++ 
Sbjct: 113 EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH-----MNAKIADFGLSNMMSDG 167

Query: 341 EFRLNYC 347
           EF    C
Sbjct: 168 EFLRTSC 174


>gi|118498345 AT-binding transcription factor 1 [Homo sapiens]
          Length = 3703

 Score = 30.4 bits (67), Expect = 4.1
 Identities = 17/50 (34%), Positives = 27/50 (54%)

Query: 51   YDYLTSLKSVPYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHL 100
            Y Y  +  S+ + + E LQL S+ H+  A  +C LC  +  TF  + +HL
Sbjct: 1399 YKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHL 1448


>gi|20128768 serine/threonine kinase 35 [Homo sapiens]
          Length = 401

 Score = 30.4 bits (67), Expect = 4.1
 Identities = 44/186 (23%), Positives = 75/186 (40%), Gaps = 36/186 (19%)

Query: 154 LGTASLAQVHKAVL-HDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWL 212
           +G  S   V++AV    G  VAVK    K+R  + +++ L             EF   W 
Sbjct: 75  IGRGSYGVVYEAVAGRSGARVAVK----KIRCDAPENVELA----------LAEF---WA 117

Query: 213 VDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDF---LKVPRIHWDLSTERVL-------- 261
           +   K+     + F         ++Q + H +    L +  +   L  ER+L        
Sbjct: 118 LTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCY 177

Query: 262 ---LMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFV--NGFVHCDPHPGNVLV 316
              +MEF +GG +N   Y+   + D       + ++ S + F+  N  VH D  P N+L+
Sbjct: 178 LWFVMEFCEGGDLNQ--YVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILI 235

Query: 317 RKHPGT 322
            +  GT
Sbjct: 236 TERSGT 241


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score = 30.4 bits (67), Expect = 4.1
 Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 12/84 (14%)

Query: 261 LLMEFVDGGQVNDRD-----YMERNKIDVN-EISRHLGKMYSEMIFVNGFVHCDPHPGNV 314
           L+ME + GG++ DR      + ER   DV   I++ +  ++S+     G VH D  P N+
Sbjct: 492 LVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-----GVVHRDLKPSNI 546

Query: 315 LVRKHPGTGKAEIVLLDHGLYQML 338
           L R   G+ ++ I + D G  + L
Sbjct: 547 LYRDESGSPES-IRVCDFGFAKQL 569


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score = 30.4 bits (67), Expect = 4.1
 Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 12/84 (14%)

Query: 261 LLMEFVDGGQVNDRD-----YMERNKIDVN-EISRHLGKMYSEMIFVNGFVHCDPHPGNV 314
           L+ME + GG++ DR      + ER   DV   I++ +  ++S+     G VH D  P N+
Sbjct: 484 LVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-----GVVHRDLKPSNI 538

Query: 315 LVRKHPGTGKAEIVLLDHGLYQML 338
           L R   G+ ++ I + D G  + L
Sbjct: 539 LYRDESGSPES-IRVCDFGFAKQL 561


>gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo
           sapiens]
          Length = 618

 Score = 30.0 bits (66), Expect = 5.4
 Identities = 16/61 (26%), Positives = 26/61 (42%)

Query: 335 YQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGIS 394
           Y M TEE R    H+W     +  +  +     +G GD    FAC     +W+  +  +S
Sbjct: 179 YAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMS 238

Query: 395 Q 395
           +
Sbjct: 239 E 239


>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
          Length = 765

 Score = 30.0 bits (66), Expect = 5.4
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 4/83 (4%)

Query: 254 DLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNG--FVHCDPHP 311
           + +TE  L+ME V GG + D       K    + S  +  + + + +++G   VH D  P
Sbjct: 459 ETATELFLVMELVKGGDLFDA-ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKP 517

Query: 312 GNVLVRKHPGTGKAEIVLLDHGL 334
            N+LV ++P  G   + L D GL
Sbjct: 518 ENLLVCEYP-DGTKSLKLGDFGL 539


>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
          Length = 766

 Score = 30.0 bits (66), Expect = 5.4
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 4/83 (4%)

Query: 254 DLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNG--FVHCDPHP 311
           + +TE  L+ME V GG + D       K    + S  +  + + + +++G   VH D  P
Sbjct: 460 ETATELFLVMELVKGGDLFDA-ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKP 518

Query: 312 GNVLVRKHPGTGKAEIVLLDHGL 334
            N+LV ++P  G   + L D GL
Sbjct: 519 ENLLVCEYP-DGTKSLKLGDFGL 540


>gi|9966821 ectonucleoside triphosphate diphosphohydrolase 7 [Homo
           sapiens]
          Length = 604

 Score = 30.0 bits (66), Expect = 5.4
 Identities = 16/43 (37%), Positives = 25/43 (58%)

Query: 195 VLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVS 237
           +L  A  +L PE + + ++ +  K+LPLE DFL     AE +S
Sbjct: 171 ILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVIS 213


>gi|38683840 CD96 antigen isoform 1 precursor [Homo sapiens]
          Length = 585

 Score = 29.6 bits (65), Expect = 7.0
 Identities = 18/70 (25%), Positives = 30/70 (42%), Gaps = 2/70 (2%)

Query: 147 QSFDDTPLGTASLAQVHKAVLHDGRTVAV--KVQHPKVRAQSSKDILLMEVLVLAVKQLF 204
           Q FDD    +  +      +L    TV V  K + P +   +S D+L+       +K +F
Sbjct: 237 QIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVF 296

Query: 205 PEFEFMWLVD 214
           P+    W +D
Sbjct: 297 PKANITWFID 306


>gi|5032141 CD96 antigen isoform 2 precursor [Homo sapiens]
          Length = 569

 Score = 29.6 bits (65), Expect = 7.0
 Identities = 18/70 (25%), Positives = 30/70 (42%), Gaps = 2/70 (2%)

Query: 147 QSFDDTPLGTASLAQVHKAVLHDGRTVAV--KVQHPKVRAQSSKDILLMEVLVLAVKQLF 204
           Q FDD    +  +      +L    TV V  K + P +   +S D+L+       +K +F
Sbjct: 221 QIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVF 280

Query: 205 PEFEFMWLVD 214
           P+    W +D
Sbjct: 281 PKANITWFID 290


>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
          Length = 1007

 Score = 29.6 bits (65), Expect = 7.0
 Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 12/85 (14%)

Query: 328 VLLDHGLYQMLTEEFRLNY----------CHLWQSLIWT-DMKRVKEYSQRLGAGDLYPL 376
           V L  GLY+  +E+  L +             W+S   + D+      S RLGA    PL
Sbjct: 497 VHLGPGLYRYTSEDAILKHRMDHSDSQWLADTWRSTSGSRDLSSSSSLSSRLGADARDPL 556

Query: 377 FACMLTARSWDSVNRGISQAPVTAT 401
             C  +  SWDS + G+   P T+T
Sbjct: 557 -DCRRSLLSWDSRSPGVPLLPDTST 580


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.136    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,186,701
Number of Sequences: 37866
Number of extensions: 750822
Number of successful extensions: 1781
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 1757
Number of HSP's gapped (non-prelim): 38
length of query: 523
length of database: 18,247,518
effective HSP length: 107
effective length of query: 416
effective length of database: 14,195,856
effective search space: 5905476096
effective search space used: 5905476096
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.