BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|39753961 IQ motif containing GTPase activating protein 3 [Homo sapiens] (1631 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|39753961 IQ motif containing GTPase activating protein 3 [Hom... 3200 0.0 gi|4506787 IQ motif containing GTPase activating protein 1 [Homo... 1916 0.0 gi|116089337 IQ motif containing GTPase activating protein 2 [Ho... 1232 0.0 gi|4557793 neurofibromin isoform 2 [Homo sapiens] 68 8e-11 gi|109826564 neurofibromin isoform 1 [Homo sapiens] 59 3e-08 gi|126116596 asp (abnormal spindle)-like, microcephaly associate... 55 7e-07 gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo s... 51 8e-06 gi|153945715 myosin VC [Homo sapiens] 48 7e-05 gi|4759026 RAS protein activator like 1 [Homo sapiens] 46 3e-04 gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 45 8e-04 gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 45 8e-04 gi|222831628 IQ motif containing F5 [Homo sapiens] 42 0.005 gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 41 0.008 gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 40 0.024 gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 40 0.024 gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 39 0.032 gi|215982794 myosin VA isoform 2 [Homo sapiens] 39 0.041 gi|215982791 myosin VA isoform 1 [Homo sapiens] 39 0.041 gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 39 0.054 gi|4507357 transgelin 2 [Homo sapiens] 39 0.054 gi|122937512 myosin VIIB [Homo sapiens] 39 0.054 gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 38 0.070 gi|5454102 transforming, acidic coiled-coil containing protein 3... 38 0.070 gi|224451032 KIAA1683 isoform a [Homo sapiens] 38 0.092 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 38 0.092 gi|224451036 KIAA1683 isoform c [Homo sapiens] 38 0.092 gi|54606862 KIAA1683 isoform b [Homo sapiens] 38 0.092 gi|28269672 serologically defined colon cancer antigen 8 [Homo s... 38 0.092 gi|156119615 myosin IXA [Homo sapiens] 37 0.12 gi|189083802 myosin VIIA isoform 2 [Homo sapiens] 37 0.12 >gi|39753961 IQ motif containing GTPase activating protein 3 [Homo sapiens] Length = 1631 Score = 3200 bits (8298), Expect = 0.0 Identities = 1631/1631 (100%), Positives = 1631/1631 (100%) Query: 1 MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEE 60 MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEE Sbjct: 1 MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEE 60 Query: 61 SLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPS 120 SLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPS Sbjct: 61 SLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPS 120 Query: 121 TFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELA 180 TFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELA Sbjct: 121 TFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELA 180 Query: 181 KYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENL 240 KYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENL Sbjct: 181 KYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENL 240 Query: 241 REPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVV 300 REPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVV Sbjct: 241 REPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVV 300 Query: 301 DDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEV 360 DDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEV Sbjct: 301 DDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEV 360 Query: 361 QAGVAAANTKGDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQL 420 QAGVAAANTKGDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQL Sbjct: 361 QAGVAAANTKGDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQL 420 Query: 421 ELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGEN 480 ELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGEN Sbjct: 421 ELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGEN 480 Query: 481 AQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSP 540 AQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSP Sbjct: 481 AQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSP 540 Query: 541 EKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRAN 600 EKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRAN Sbjct: 541 EKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRAN 600 Query: 601 QDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAK 660 QDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAK Sbjct: 601 QDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAK 660 Query: 661 KQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAA 720 KQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAA Sbjct: 661 KQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAA 720 Query: 721 YDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY 780 YDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY Sbjct: 721 YDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY 780 Query: 781 LEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY 840 LEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY Sbjct: 781 LEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY 840 Query: 841 RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDI 900 RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDI Sbjct: 841 RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDI 900 Query: 901 KIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLF 960 KIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLF Sbjct: 901 KIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLF 960 Query: 961 YLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKS 1020 YLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKS Sbjct: 961 YLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKS 1020 Query: 1021 KVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYK 1080 KVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYK Sbjct: 1021 KVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYK 1080 Query: 1081 NWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQI 1140 NWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQI Sbjct: 1081 NWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQI 1140 Query: 1141 PYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGA 1200 PYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGA Sbjct: 1141 PYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGA 1200 Query: 1201 LAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPE 1260 LAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPE Sbjct: 1201 LAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPE 1260 Query: 1261 ERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPT 1320 ERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPT Sbjct: 1261 ERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPT 1320 Query: 1321 IPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFH 1380 IPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFH Sbjct: 1321 IPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFH 1380 Query: 1381 PGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRV 1440 PGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRV Sbjct: 1381 PGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRV 1440 Query: 1441 LRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTF 1500 LRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTF Sbjct: 1441 LRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTF 1500 Query: 1501 YEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFR 1560 YEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFR Sbjct: 1501 YEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFR 1560 Query: 1561 NVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLL 1620 NVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLL Sbjct: 1561 NVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLL 1620 Query: 1621 IFLLNKKFLRK 1631 IFLLNKKFLRK Sbjct: 1621 IFLLNKKFLRK 1631 >gi|4506787 IQ motif containing GTPase activating protein 1 [Homo sapiens] Length = 1657 Score = 1916 bits (4964), Expect = 0.0 Identities = 970/1635 (59%), Positives = 1250/1635 (76%), Gaps = 18/1635 (1%) Query: 14 ERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGH 73 ERLTAEEMDE+RRQNVAY+YLC LEEAKRWMEACL E+LP ELEE LRNGV LAKLG+ Sbjct: 24 ERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGN 83 Query: 74 CFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKK 133 F+P VV LKKIYD EQ RY+ATGLHFRHTDN+ WL+A+ IGLP F+PETTDIYD+K Sbjct: 84 FFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRK 143 Query: 134 NMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIG 193 NMPR +YCIHALSL+LF+LGLAPQI DLYGKV FT EE++NM +EL KYG+Q+PAFSKIG Sbjct: 144 NMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIG 203 Query: 194 GILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLA 253 GILANELSVDEAA+HAAV+AINEA++R + DT AAL+NP+A+L NL EPLA+ YQ++L Sbjct: 204 GILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILY 263 Query: 254 QAKMEKAANARNHDDRESQ--DIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPEA 311 QAK +K NA+N + + D+Y+ LTQAEIQGNIN VN AL +D ALE+ A Sbjct: 264 QAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALA 323 Query: 312 LLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTKG 371 L +ALQ PAL LRG+++ +DWYL+QL SD++QK Q G + L+KEE+Q+GV AAN+ Sbjct: 324 LFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS-GQTDPLQKEELQSGVDAANSAA 382 Query: 372 DQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQGE 431 Q Q L AV IN AI++GVA TV ELM PEAQLP VYP A+ +YQ ELA LQ+Q E Sbjct: 383 QQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPE 442 Query: 432 --LGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALL 489 L EL VAVEMLS+V LINRALE+ D + W L + TGL +E EN QRY D L+ Sbjct: 443 HNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELM 502 Query: 490 KLR-QERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALL 548 KL+ Q +F++WND+QA V VN QEE +R+LA+ LINEALD+G +KTL AL Sbjct: 503 KLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQ 562 Query: 549 LPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQR 608 +PAA L+ V VA Y L+ AKR+KAQ D AVLWL+EI+ G+ ++N+DT AQ+ Sbjct: 563 IPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQK 622 Query: 609 MALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAKKQRPADT- 667 ALG+ AIN+A++ G +T LR+P V L GV+P+C Y L A KK D Sbjct: 623 FALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNN 682 Query: 668 AFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLW 727 + WV+H +K G YY +L+T +G W++PP N+ L+REEIQS+++ VTAAY+R+QLW Sbjct: 683 SKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLW 742 Query: 728 KANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYF 787 AN G + +LQAR RG+LVRQ+F +FL+ +PA+ IQ+ WRGY+Q+K Y + L Y Sbjct: 743 LANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYL 802 Query: 788 KANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAP 847 +++ D ++KIQ+ ARM AR++Y RL YF+ ++N I+KIQAF RA KA+DDY+ L++A Sbjct: 803 RSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAE 862 Query: 848 HPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVK 907 PP+ VVR+F HLL+QS QDF E +L+K++EEV+ IRSNQQLE DLN+MDIKIGLLVK Sbjct: 863 DPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVK 922 Query: 908 NRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKG-LKSLSKEKRQKLEAYQHLFYLLQTQ 966 N+ITLQ+VVSH KKLTK+NKEQLSDMM+++KQKG LK+LSKEKR+KLEAYQHLFYLLQT Sbjct: 923 NKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTN 982 Query: 967 PIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQ 1026 P YLAKLIFQMPQNK+TKFM++VIF+LYNYAS++RE YLLL+LFKTALQEEIKSKV+Q Q Sbjct: 983 PTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQ 1042 Query: 1027 DVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQT 1086 ++VTGNPTV+++VV F R RGQ+AL++IL V++++++DK L++ TDPV +YK+W+NQ Sbjct: 1043 EIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQM 1102 Query: 1087 EAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRY 1146 E+QTG+ S LPYDVTPEQAL+H EV+ RLD ++RN+ A+TDKFL AI SSVD+IPYGMR+ Sbjct: 1103 ESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRF 1162 Query: 1147 VAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQR 1206 +AKVLK +L EKFPDA + E+ K++GNLLYYR++NPA+VAPDAFDI+ ++AGG L QR Sbjct: 1163 IAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQR 1222 Query: 1207 HALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVD 1266 LG++A++LQHAA+ K F G + HL ++N+YL +++ KFR+F AC VPE +++F VD Sbjct: 1223 RNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVD 1282 Query: 1267 EYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIG 1326 EYSD+V + KP++YI++GE++NTH LLL+HQD IAP+H DP+HELL+DLGE+PTI LIG Sbjct: 1283 EYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIG 1342 Query: 1327 ES---IAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGD 1383 ES + L+K EVSLTLTNKF+ + + + R++LL+TK+L+ D+I+F PG+ Sbjct: 1343 ESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGE 1402 Query: 1384 TLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRN 1443 TL EIL A+ EQEA H++ M RR A+TP+ +++ +S+ S L L EK+ ++ Sbjct: 1403 TLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTG 1462 Query: 1444 LRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEE 1503 L++L LG V +N YQ L++++A+DIRNQ R+R RRKAELVKLQ T L++K TFY E Sbjct: 1463 LKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGE 1522 Query: 1504 QGDYYSQYIRACLDHLAPDSKSS-------GKGKKQPSLHYTAAQLLEKGVLVEIEDLPA 1556 Q DYY YI+ CLD+LA K S GK K+ SL YTAA+L EKGVL+EIEDL Sbjct: 1523 QVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQV 1582 Query: 1557 SHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVN 1616 + F+NVIF+I+P +E G FEV AKF+GV ME F LHYQDLLQLQYEGVAVMKLF++AKVN Sbjct: 1583 NQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVN 1642 Query: 1617 VNLLIFLLNKKFLRK 1631 VNLLIFLLNKKF K Sbjct: 1643 VNLLIFLLNKKFYGK 1657 >gi|116089337 IQ motif containing GTPase activating protein 2 [Homo sapiens] Length = 1575 Score = 1232 bits (3187), Expect = 0.0 Identities = 656/1379 (47%), Positives = 925/1379 (67%), Gaps = 45/1379 (3%) Query: 287 NINHVNVHGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKA 346 +++ +H A+ +++A+E+ E + L++P L V + A Y ++L +++K Sbjct: 208 SVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKE 267 Query: 347 QELGLV-------------ELLEKEEVQAGVAAANTKGDQEQAMLHAVQRINKAIRRGVA 393 + L ELL + E+Q + N + AV IN I G Sbjct: 268 ENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQA--------AVDHINAVIPEGDP 319 Query: 394 ADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQ--GELGQEELFVAVEMLSAVVLIN 451 +T+ L PEAQLP VYP A++MYQ EL LQ+Q L EEL +AVEMLSAV L+N Sbjct: 320 ENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLN 379 Query: 452 RALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALLKLRQE-RGMGEDFLSWNDLQAT 510 +ALE+ D + L +PA GL ++ +RY + LL ++ E G+D LSWN++Q Sbjct: 380 QALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNC 439 Query: 511 VSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYHLLLV 570 + VNAQ QEE DRV+AV INEA+D+G+P +TL LLLP A + DV A Y +L Sbjct: 440 IDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLY 499 Query: 571 AAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQRMALGVAAINQAIKEGKAAQTER 630 AK QK + VLWL+EI+Q V AN D + A++ V +NQ ++ K++ Sbjct: 500 HAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVDVNQCLEGKKSSDILS 559 Query: 631 VLRNPAVALRGVVPDCANGYQRALESAMA-KKQRPADTAFWVQHDMKDGTAYYFHLQTFQ 689 VL++ ++P+CA+ Y AL A K +R + W++ ++ YY++ + + Sbjct: 560 VLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKE 619 Query: 690 GIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQK 749 W P C S LT +EI+ + +VT Y R+ +W A+ +++ QA G ++R++ Sbjct: 620 SSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREE 679 Query: 750 FAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQ 809 F FL V+KIQA W+GY+QRK Y+ Q F N D+I+KIQ+W RM AR+ Sbjct: 680 FEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKS 739 Query: 810 YLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFL 869 YL RL YF+ + N IVKIQ+ RA KA+DDY+ LV + +PPL+V+R+F +LL+QS DF Sbjct: 740 YLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQ 799 Query: 870 AEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQ 929 E E+ +L+EEVV KIR+NQQLE+DLN+MDIKIGLLVKNRITL++V+SH KKL K+ + Sbjct: 800 EELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGE 859 Query: 930 LSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEAV 989 + + D Q G+KSLSKE+R+ LE YQ LFYLLQT P+YLAKLIFQMPQNK+TKFM+ V Sbjct: 860 MEILNNTDNQ-GIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTV 918 Query: 990 IFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQ 1049 IF+LYNYAS++RE YLLL+LFKTAL+EEIKSKV+Q QD+VTGNPTV+++VV F R RGQ Sbjct: 919 IFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQ 978 Query: 1050 SALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHP 1109 + L+++L V++++++DK L ++T+PV +YK W+NQ E QTG+ S LPYDVT EQAL++P Sbjct: 979 NTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYP 1038 Query: 1110 EVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYK 1169 EV+ +L+ ++ NL +TDK L +I SS+D +PYG+RY+AKVLK ++ EKFPDAT+ E+ K Sbjct: 1039 EVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLK 1098 Query: 1170 VVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQS 1229 +VGNLLYYR++NPA+VAPD FDI+ M AGG + + QR LG+VA++LQHAA+ K F G++ Sbjct: 1099 IVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGEN 1158 Query: 1230 QHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVGELVNT 1289 +HL +N+YL ET+ +FRK+ AC VPEPEE+F +D+Y+D+V V+KP++YI++ E+++T Sbjct: 1159 EHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIIST 1218 Query: 1290 HRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIA-------ADGHTDLSKLEV 1342 H LLLEHQD IAP+ D L ELL LGE+PT+ +GE A+ + LSK E+ Sbjct: 1219 HSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEI 1278 Query: 1343 SLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGDTLKEILSLSASREQEAAHK 1402 SL LT+K++ + +A DS RSL++ TK+L+ D+I+ PG+TL EIL A+ +QE H Sbjct: 1279 SLVLTSKYDIEDGEAIDS--RSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHA 1336 Query: 1403 QLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRNLRRLEALGLVSARNGYQGL 1462 M R ++TPE ++ +S+ + LPL +K+R++ RNLR LE G VS+ N YQ + Sbjct: 1337 TDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDI 1396 Query: 1463 VDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPD 1522 ++E+AKDIRNQ +R RKAEL KLQ TL L+ K FYEEQ +YY YI+ CLD+L Sbjct: 1397 LNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRK 1456 Query: 1523 S-----KSSGKG-----KKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEA 1572 + K GKG K+ + YTAA+L EKGVL++I+DL + F+NV FDI ++ Sbjct: 1457 NTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDV 1516 Query: 1573 GKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLLIFLLNKKFLRK 1631 G F+V +KFLGV+ME+ QL+ QDLLQ+QYEGVAVMK+F+K KVNVNLLI+LLNKKF K Sbjct: 1517 GIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK 1575 Score = 433 bits (1113), Expect = e-121 Identities = 259/600 (43%), Positives = 351/600 (58%), Gaps = 41/600 (6%) Query: 14 ERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGH 73 ERL+AEEMDE+RRQN+AY+YLC LEEAKRWME CL EELP ELEE LRNGV LAKL Sbjct: 21 ERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAK 80 Query: 74 CFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKK 133 FAP +V KKIYDVEQ RY+ +GLHFRHTDN WL A+ IGLP F+PETTD+YD+K Sbjct: 81 FFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRK 140 Query: 134 NMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIG 193 N+PR++YCIHALSL+LF+LG+APQI DL GKV FT EE+SNM EL KYG+Q+P+FSKIG Sbjct: 141 NIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIG 200 Query: 194 GILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLA 253 GILANELSVDEAA+HAAV+AINEAVE+G+ E T+ L+NP+A+L + + LA YQ+ L Sbjct: 201 GILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELW 260 Query: 254 QAKMEKAANARNHD---DRESQDIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPE 310 AK +K NAR + E +D Y+ LTQAEIQGNIN VN A++ ++ + PE Sbjct: 261 DAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPE 320 Query: 311 ALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTK 370 L AL+ P L V A Y +L + ++Q + L EE+ V Sbjct: 321 NTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNT-----MNYLAHEELLIAV------ 369 Query: 371 GDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQL-----PPVYPVASSMYQLELAVL 425 ML AV +N+A+ +L P L V A+++ ++L VL Sbjct: 370 -----EMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVL 424 Query: 426 QQQQGELGQEELFVAVEMLS-----------AVVLINRALEARDASGFWSSLVNPATGLA 474 Q Q L E+ ++M++ AV IN A++ + +L+ P ++ Sbjct: 425 SQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANIS 484 Query: 475 EVEGENAQRYFDALLKLRQERGMGEDFLS---W-NDLQATVSQVNAQTQEETDRVLAVSL 530 +V+ +AQ Y D L + ++ + +S W +++Q V N V V Sbjct: 485 DVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVD 544 Query: 531 INEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLE 590 +N+ L+ LS L + +D+ A +Y+ LV AK K++ G+ WL+ Sbjct: 545 VNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGS--WLK 602 Score = 40.4 bits (93), Expect = 0.014 Identities = 26/71 (36%), Positives = 37/71 (52%) Query: 595 GVVRANQDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRAL 654 G + AN+ + + V AIN+A+++G A QT LRNP L V + A YQ+ L Sbjct: 200 GGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKEL 259 Query: 655 ESAMAKKQRPA 665 A KK+ A Sbjct: 260 WDAKKKKEENA 270 >gi|4557793 neurofibromin isoform 2 [Homo sapiens] Length = 2818 Score = 67.8 bits (164), Expect = 8e-11 Identities = 72/300 (24%), Positives = 131/300 (43%), Gaps = 56/300 (18%) Query: 1004 YLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDV 1063 +LL QL +E++ + Q + GN ++ ++ F G + LQ++L +++ V Sbjct: 1251 HLLYQLLWNMFSKEVEL-ADSMQTLFRGN-SLASKIMTFCFKVYGATYLQKLLDPLLRIV 1308 Query: 1064 LEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLL 1123 + +W H+ ++V P + E L+ RNLL Sbjct: 1309 ITSS-------------DW-----------QHVSFEVDPTRL----EPSESLEENQRNLL 1340 Query: 1124 AMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPA 1183 MT+KF AI SS + P +R V L ++++FP + VG+ ++ RF+NPA Sbjct: 1341 QMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS----IGAVGSAMFLRFINPA 1396 Query: 1184 VVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETH 1243 +V+P I+ + L ++++LQ A F+ + +H+R ND+++ Sbjct: 1397 IVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFT-KEEHMRPFNDFVKSNF 1451 Query: 1244 LKFRKFIHRACQVPEPEERFAVDEYSDMV---AVAKPMVYITVGELVNTHRLLLEHQDCI 1300 + RF +D SD AV + +I+ G ++ HRLL +Q+ I Sbjct: 1452 --------------DAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKI 1497 >gi|109826564 neurofibromin isoform 1 [Homo sapiens] Length = 2839 Score = 59.3 bits (142), Expect = 3e-08 Identities = 75/317 (23%), Positives = 131/317 (41%), Gaps = 69/317 (21%) Query: 1004 YLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDV 1063 +LL QL +E++ + Q + GN ++ ++ F G + LQ++L +++ V Sbjct: 1251 HLLYQLLWNMFSKEVEL-ADSMQTLFRGN-SLASKIMTFCFKVYGATYLQKLLDPLLRIV 1308 Query: 1064 LEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLL 1123 + +W H+ ++V P + E L+ RNLL Sbjct: 1309 ITSS-------------DW-----------QHVSFEVDPTRL----EPSESLEENQRNLL 1340 Query: 1124 AMTDKFLLAITSSVDQIPYGMRYVAKVL----------KATLAEKFPDATD-------SE 1166 MT+KF AI SS + P +R V L KAT+ EK + Sbjct: 1341 QMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQN 1400 Query: 1167 VYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFS 1226 VG+ ++ RF+NPA+V+P I+ + L ++++LQ A F+ Sbjct: 1401 SIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFT 1456 Query: 1227 GQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMV---AVAKPMVYITV 1283 + +H+R ND+++ + RF +D SD AV + +I+ Sbjct: 1457 -KEEHMRPFNDFVKSNF--------------DAARRFFLDIASDCPTSDAVNHSLSFISD 1501 Query: 1284 GELVNTHRLLLEHQDCI 1300 G ++ HRLL +Q+ I Sbjct: 1502 GNVLALHRLLWNNQEKI 1518 >gi|126116596 asp (abnormal spindle)-like, microcephaly associated [Homo sapiens] Length = 3477 Score = 54.7 bits (130), Expect = 7e-07 Identities = 34/102 (33%), Positives = 53/102 (51%), Gaps = 15/102 (14%) Query: 710 IQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQA 769 +Q+ +A ++Q++ VI +QAR +GF+ ++KF E + + IKIQA Sbjct: 2889 LQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKN-------STIKIQA 2941 Query: 770 HWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYL 811 WR YR +K + + A KIQAW R W A ++YL Sbjct: 2942 MWRRYRAKK--------YLCKVKAACKIQAWYRCWRAHKEYL 2975 Score = 49.3 bits (116), Expect = 3e-05 Identities = 42/137 (30%), Positives = 69/137 (50%), Gaps = 20/137 (14%) Query: 709 EIQSAVTKVTAAYDR---QQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVI 765 +++ A T + AAY +QL K +++Q+ RG+ R K+ ++ L ++I Sbjct: 1800 QVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKY-------QSVLQSII 1852 Query: 766 KIQAHWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIV 825 KIQ R YR K + +F A+I +Q+ R W R+Q +RR H + + Sbjct: 1853 KIQ---RWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQ-IRREH------QAAL 1902 Query: 826 KIQAFFRARKAQDDYRI 842 KIQ+ FR KAQ +R+ Sbjct: 1903 KIQSAFRMAKAQKQFRL 1919 Score = 43.1 bits (100), Expect = 0.002 Identities = 65/281 (23%), Positives = 109/281 (38%), Gaps = 81/281 (28%) Query: 753 HSHFLRTWLP-AVIKIQAHWRGYRQRKIYL---------------------EWLQYFKAN 790 H HFL A IQAH+RGY+ R+++L E ++Y + Sbjct: 3021 HEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKHERIKYIEFK 3080 Query: 791 LDAIIKIQAWARMWAARRQYL------RRLHY-------------------------FQK 819 +I +QA R W R+++L R LH+ K Sbjct: 3081 KSTVI-LQALVRGWLVRKRFLEQRAKIRLLHFTAAAYYHLNAVRIQRAYKLYLAVKNANK 3139 Query: 820 NVNSIVKIQAFFRARKAQDDY-------RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEA 872 VNS++ IQ +FRAR + + + + H LS R A ++ ++ + FL Sbjct: 3140 QVNSVICIQRWFRARLQEKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVRHFLLRK 3199 Query: 873 ELLKLQEEVVR-----KIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNK 927 + K +++ + S ++ I I++ L V NR +E KL KR Sbjct: 3200 KQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREE-----NKLYKRTA 3254 Query: 928 EQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPI 968 L ++ K L ++ LEA +HL + + P+ Sbjct: 3255 LALHYLLT---YKHLSAI-------LEALKHLEVVTRLSPL 3285 Score = 40.4 bits (93), Expect = 0.014 Identities = 38/143 (26%), Positives = 68/143 (47%), Gaps = 29/143 (20%) Query: 710 IQSAVTK-VTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFA-EHSHFLRTWLP----- 762 IQ A + VT + Q+ + F +Q+ R F+ +++ A H+ RTW Sbjct: 2821 IQKAFCRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFL 2880 Query: 763 ----AVIKIQAHWRGY----RQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRL 814 A + +Q H+R + QR++YL+ ++I IQA ++ + +R+ Sbjct: 2881 LYRKAAVVLQNHYRAFLSAKHQRQVYLQIRS-------SVIIIQARSKGFIQKRK----- 2928 Query: 815 HYFQKNVNSIVKIQAFFRARKAQ 837 FQ+ NS +KIQA +R +A+ Sbjct: 2929 --FQEIKNSTIKIQAMWRRYRAK 2949 Score = 39.7 bits (91), Expect = 0.024 Identities = 51/246 (20%), Positives = 106/246 (43%), Gaps = 48/246 (19%) Query: 708 EEIQSAVTKVTAAYDRQQLWKANVGF---VIQLQARLRGFLVRQKFAEHSHFLRTWLPAV 764 ++ +SAV + +AY Q K + VI++Q+ R ++ +++F + A Sbjct: 1630 QKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKN-------AT 1682 Query: 765 IKIQA------------HWRG--------YRQRKIYLEWLQYFKANLDAIIKIQAWARMW 804 IK+Q+ H R YR +KI + + + ++ IK+QA+ R + Sbjct: 1683 IKLQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGY 1742 Query: 805 AARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLN-- 862 R+Q + +++ +Q++FR RKA+ Y + A + V++ + H Sbjct: 1743 LVRKQ-------MRLQRKAVISLQSYFRMRKARQYYLKMYKA----IIVIQNYYHAYKAQ 1791 Query: 863 -QSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVK---NRITLQEVVSH 918 +++FL + + R + Q ++Q +I +KI + R+ Q V+ Sbjct: 1792 VNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQ-SIAALKIQSAFRGYNKRVKYQSVLQS 1850 Query: 919 CKKLTK 924 K+ + Sbjct: 1851 IIKIQR 1856 Score = 38.1 bits (87), Expect = 0.070 Identities = 45/165 (27%), Positives = 75/165 (45%), Gaps = 25/165 (15%) Query: 737 LQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIK 796 LQA RG VR+ LR A IQ+++R YRQ+ YF L I K Sbjct: 2173 LQASFRGVRVRRT-------LRKMQTAATLIQSNYRRYRQQT-------YFN-KLKKITK 2217 Query: 797 IQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRR 856 R WA + + ++ Y K +S++ IQA FR +KA+ +++ A + RR Sbjct: 2218 T-VQQRYWAMKERNIQFQRY-NKLRHSVIYIQAIFRGKKARRHLKMMHIA---ATLIQRR 2272 Query: 857 FAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIK 901 F L+ + + L + +L + RK R++ + L + ++ Sbjct: 2273 FRTLMMRRRFLSLKKTAIL-----IQRKYRAHLCTKHHLQFLQVQ 2312 Score = 37.7 bits (86), Expect = 0.092 Identities = 43/178 (24%), Positives = 84/178 (47%), Gaps = 40/178 (22%) Query: 764 VIKIQAHWRGYRQRKIY--------------------LEWLQYFKANLDAIIKIQAWARM 803 +IK QAH R ++QR+ Y ++ L ++ A+I +Q+ R Sbjct: 1586 IIKFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRG 1645 Query: 804 WAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQ 863 AR+ Y+ L S++KIQ+++RA ++ ++ L +A S V+ + Q Sbjct: 1646 MQARKMYIHIL-------TSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVK-----MKQ 1693 Query: 864 SQQDFL-AEAELLKLQEEVVRKIRSNQQLEQDLNIMD--IKI-----GLLVKNRITLQ 913 +++ +L A L +Q+ K + Q+ E+ + + + IK+ G LV+ ++ LQ Sbjct: 1694 TRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQ 1751 Score = 37.4 bits (85), Expect = 0.12 Identities = 67/287 (23%), Positives = 125/287 (43%), Gaps = 45/287 (15%) Query: 737 LQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIK 796 +Q R R ++R++F I IQ +R + K +L++LQ +A+IK Sbjct: 2269 IQRRFRTLMMRRRFLSLKK-------TAILIQRKYRAHLCTKHHLQFLQV----QNAVIK 2317 Query: 797 IQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRR 856 IQ+ R W R++ +R +H + IQ+ FR + Y+ L A SVV + Sbjct: 2318 IQSSYRRWMIRKR-MREMH------RAATFIQSTFRMHRLHMRYQALKQA-----SVVIQ 2365 Query: 857 FAHLLNQS----QQDFLAEAELLKLQEEVVRKIRSNQQLE---QDLNIMDIKI-GLLVKN 908 + N++ +Q +L + + + R +++ + L+ ++ + LLV+ Sbjct: 2366 QQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRR 2425 Query: 909 R-ITLQEV---VSHCKKLTKRNKEQLSDMMVLDK-----QKGLKSLSKEKRQKLEAYQHL 959 R I+L++ V + T K +L + L K Q + L +K KL+ Q Sbjct: 2426 RFISLKKATIFVQRKYRATICAKHKLYQFLHLRKAAITIQSSYRRLMVKK--KLQEMQRA 2483 Query: 960 FYLLQ-TQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYL 1005 L+Q T +Y + FQ ++ + + + Y A +RE Y+ Sbjct: 2484 AVLIQATFRMYRTYITFQTWKHASILIQQH--YRTYRAAKLQRENYI 2528 Score = 36.6 bits (83), Expect = 0.20 Identities = 37/157 (23%), Positives = 64/157 (40%), Gaps = 40/157 (25%) Query: 708 EEIQSAVTKVTAAY-----DRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLP 762 E++Q+ + Y RQ+ K +I LQ+R+R + + + +L Sbjct: 1344 EKVQNKAASLIQGYWRRYSTRQRFLKLKYYSII-LQSRIRMIIAVTSY-------KRYLW 1395 Query: 763 AVIKIQAHWRGYRQRK------------------IYLEWLQ-YFKANLDAIIKIQAWARM 803 A + IQ HWR Y +RK ++ +W Q ++ + A + +Q R Sbjct: 1396 ATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQRAFRE 1455 Query: 804 WAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY 840 W R+Q K NS + IQ+++R K Y Sbjct: 1456 WHLRKQ--------AKEENSAIIIQSWYRMHKELRKY 1484 Score = 33.9 bits (76), Expect = 1.3 Identities = 35/158 (22%), Positives = 73/158 (46%), Gaps = 28/158 (17%) Query: 763 AVIKIQAHWRGYRQRKIYL-----------EWLQYFKANLDAIIKIQAWARMWAARRQYL 811 A I IQ H + ++ RK YL + + A+I IQ++ R + R+ + Sbjct: 2627 AAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKD-I 2685 Query: 812 RRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHL---LNQSQQDF 868 + +H + IQ+F+R +A+ DY A + V++ + L + +++F Sbjct: 2686 QNMH------RAATLIQSFYRMHRAKVDYETKKTA----IVVIQNYYRLYVRVKTERKNF 2735 Query: 869 LAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLV 906 LA + ++ + R ++ Q+L+ N+ + K+ +V Sbjct: 2736 LAVQKSVRTIQAAFRGMKVRQKLK---NVSEEKMAAIV 2770 Score = 31.6 bits (70), Expect = 6.6 Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 15/106 (14%) Query: 710 IQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQA 769 IQS+ ++ Q++ +A + +QA R + F +TW A I IQ Sbjct: 2464 IQSSYRRLMVKKKLQEMQRA----AVLIQATFRMYRTYITF-------QTWKHASILIQQ 2512 Query: 770 HWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLH 815 H+R YR K+ E Y + A++ A+ M A RQ LR H Sbjct: 2513 HYRTYRAAKLQRE--NYIRQWHSAVVIQAAYKGMKA--RQLLREKH 2554 >gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo sapiens] Length = 1487 Score = 51.2 bits (121), Expect = 8e-06 Identities = 87/424 (20%), Positives = 174/424 (41%), Gaps = 49/424 (11%) Query: 885 IRSNQQLEQDLNIMDIKIG--------LLVKNRITLQEVVSHCKKLTK----RNKEQLSD 932 + S +QL Q LN +K + + RI L ++ + + ++ + L D Sbjct: 20 VNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILED 79 Query: 933 MMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAKLIF---QMPQNKTTKFMEAV 989 +D G K L ++ AY L+ P +A + ++ Q T + V Sbjct: 80 TQFVD---GYKQLGFQET----AYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTV 132 Query: 990 IFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNG--R 1047 SLY + + LLQ+ + ++ E+K + P+ ++ ++ + + G Sbjct: 133 FTSLYGNCIMQEDESYLLQVLRYLIEFELKES-DNPRRLLRRGTCAFSILFKLFSEGLFS 191 Query: 1048 GQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWI-NQTEAQTGQRSHLPYDVTPEQAL 1106 + L L + I +L + + TDP L + + +Q E G++ + Sbjct: 192 AKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRF-------- 243 Query: 1107 SHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATD-S 1165 +VQ ++ L+A+ +KF+ + + P+ +R++ + TL+ D + Sbjct: 244 -RQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLS--CVDRLEVG 300 Query: 1166 EVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAF 1225 EV + +LL F+ PAVV P+ + I++ A +A R L V +LLQ A + Sbjct: 301 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVA---RFNLMQVGRLLQQLAMTGSE 357 Query: 1226 SGQSQHLRVLNDYLEETHLKFRKFI--HRACQVPEPEERFAVDEYSDMVAVAKPMVYITV 1283 G + L + + F + RA + P + + + +++ +VYIT Sbjct: 358 EGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETP------PLSSVNLLEGLSRTVVYITY 411 Query: 1284 GELV 1287 +L+ Sbjct: 412 SQLI 415 >gi|153945715 myosin VC [Homo sapiens] Length = 1742 Score = 48.1 bits (113), Expect = 7e-05 Identities = 57/247 (23%), Positives = 106/247 (42%), Gaps = 34/247 (13%) Query: 711 QSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAH 770 Q V K A ++ W A I +Q RG+LVR + +R A I +QA+ Sbjct: 793 QQTVRKAITAVALKEAWAA-----IIIQKHCRGYLVRSLY----QLIRM---ATITMQAY 840 Query: 771 WRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAF 830 RG+ R+ Y + L+ KA + +Q +AR W ARR++ + + F N+ ++Q Sbjct: 841 SRGFLARRRYRKMLEEHKA-----VILQKYARAWLARRRF-QSIRRFVLNIQLTYRVQ-- 892 Query: 831 FRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQ 890 R +K +D H +V + L D ++ KL+ E+ + + Sbjct: 893 -RLQKKLEDQNKENH------GLVEKLTSLAALRAGDV---EKIQKLEAELEKAATHRRN 942 Query: 891 LEQD----LNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLS 946 E+ + ++ K+ L K+ L+ + + E+L + M ++ + Sbjct: 943 YEEKGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQ 1002 Query: 947 KEKRQKL 953 KE+RQ++ Sbjct: 1003 KEERQRM 1009 >gi|4759026 RAS protein activator like 1 [Homo sapiens] Length = 804 Score = 46.2 bits (108), Expect = 3e-04 Identities = 40/146 (27%), Positives = 63/146 (43%), Gaps = 19/146 (13%) Query: 1048 GQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALS 1107 G L E+L VI V E+K + DP + G+ + + + ALS Sbjct: 359 GMPYLHEVLKPVISRVFEEKKY-MELDPCKM----------DLGRTRRISF----KGALS 403 Query: 1108 HPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEV 1167 +++ + +L L + AI SV + P MR K L + E+FP A +V Sbjct: 404 EEQMR---ETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDV 460 Query: 1168 -YKVVGNLLYYRFLNPAVVAPDAFDI 1192 Y + L+ RF PA++ P FD+ Sbjct: 461 KYLAISGFLFLRFFAPAILTPKLFDL 486 >gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] Length = 1047 Score = 44.7 bits (104), Expect = 8e-04 Identities = 46/221 (20%), Positives = 90/221 (40%), Gaps = 35/221 (15%) Query: 1099 DVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEK 1158 +++P + + +V L L L + +K +A + +P +RY+ L+ ++ K Sbjct: 829 ELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS----EILPPTLRYIYGCLQKSVQHK 884 Query: 1159 FPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQH 1218 +P T +VV ++ R + PA++ P F+I++ + A L VA+ +Q+ Sbjct: 885 WPTNTTMRT-RVVSGFVFLRLICPAILNPRMFNIISDSPSPIAA----RTLILVAKSVQN 939 Query: 1219 AAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPE---PEERFAVDEYSDMVAVA 1275 A F + ++ +N +++ + F+ VPE E D D+ A+ Sbjct: 940 LANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAAL- 998 Query: 1276 KPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLG 1316 H+ C+A H D L L + G Sbjct: 999 --------------------HEICVA--HSDELRTLSNERG 1017 >gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] Length = 870 Score = 44.7 bits (104), Expect = 8e-04 Identities = 46/221 (20%), Positives = 90/221 (40%), Gaps = 35/221 (15%) Query: 1099 DVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEK 1158 +++P + + +V L L L + +K +A + +P +RY+ L+ ++ K Sbjct: 652 ELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS----EILPPTLRYIYGCLQKSVQHK 707 Query: 1159 FPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQH 1218 +P T +VV ++ R + PA++ P F+I++ + A L VA+ +Q+ Sbjct: 708 WPTNTTMRT-RVVSGFVFLRLICPAILNPRMFNIISDSPSPIAA----RTLILVAKSVQN 762 Query: 1219 AAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPE---PEERFAVDEYSDMVAVA 1275 A F + ++ +N +++ + F+ VPE E D D+ A+ Sbjct: 763 LANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAAL- 821 Query: 1276 KPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLG 1316 H+ C+A H D L L + G Sbjct: 822 --------------------HEICVA--HSDELRTLSNERG 840 >gi|222831628 IQ motif containing F5 [Homo sapiens] Length = 148 Score = 42.0 bits (97), Expect = 0.005 Identities = 31/102 (30%), Positives = 51/102 (50%), Gaps = 23/102 (22%) Query: 737 LQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGY------RQRKIYLEWLQYFKAN 790 +QA RG LVR+ + LR W+ IQ WR ++R++ LE ++ Sbjct: 18 IQAWWRGMLVRRTLLHAA--LRAWI-----IQCWWRQVLEKLLAKRRRMVLE---FYVQQ 67 Query: 791 LDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFR 832 A +++Q+W RMW R++Y R L N++ IQ ++R Sbjct: 68 EWAAVRLQSWVRMWCVRQRYCRLL-------NAVRIIQVYWR 102 >gi|38201692 RAS p21 protein activator 3 [Homo sapiens] Length = 834 Score = 41.2 bits (95), Expect = 0.008 Identities = 26/100 (26%), Positives = 47/100 (47%), Gaps = 5/100 (5%) Query: 1093 RSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLK 1152 +SH P ++ P + ++ ++ NL D+ AIT S P M + L+ Sbjct: 405 QSHKPCEIDPVKLKDGENLENNME----NLRQYVDRVFHAITESGVSCPTVMCDIFFSLR 460 Query: 1153 ATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDI 1192 A++F D D Y V + ++ RF PA+++P+ F + Sbjct: 461 EAAAKRFQDDPDVR-YTAVSSFIFLRFFAPAILSPNLFQL 499 >gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo sapiens] Length = 1065 Score = 39.7 bits (91), Expect = 0.024 Identities = 44/198 (22%), Positives = 80/198 (40%), Gaps = 31/198 (15%) Query: 1169 KVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQ 1228 +++ L+ RFL PA+++P F+++ A L +A++ Q+ A F + Sbjct: 391 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTA----RTLTLIAKVTQNLANFAKFGSK 446 Query: 1229 SQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVG-ELV 1287 +++ +N +LE ++F+ ++ PE + YI +G EL Sbjct: 447 EEYMSFMNQFLEHEWTNMQRFL---LEISNPETLSNTAGFEG---------YIDLGRELS 494 Query: 1288 NTHRLLLEHQDCIAP---DHQDPLHELLEDL---------GELPTIPDLIGESIAADGHT 1335 + H LL E + PL +L D+ G+LP DL S G + Sbjct: 495 SLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDL--ASTPGSGSS 552 Query: 1336 DLSKLEVSLTLTNKFEGL 1353 +S + + N GL Sbjct: 553 SISAGLQKMVIENDLSGL 570 >gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo sapiens] Length = 1132 Score = 39.7 bits (91), Expect = 0.024 Identities = 44/198 (22%), Positives = 80/198 (40%), Gaps = 31/198 (15%) Query: 1169 KVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQ 1228 +++ L+ RFL PA+++P F+++ A L +A++ Q+ A F + Sbjct: 487 RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTA----RTLTLIAKVTQNLANFAKFGSK 542 Query: 1229 SQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVG-ELV 1287 +++ +N +LE ++F+ ++ PE + YI +G EL Sbjct: 543 EEYMSFMNQFLEHEWTNMQRFL---LEISNPETLSNTAGFEG---------YIDLGRELS 590 Query: 1288 NTHRLLLEHQDCIAP---DHQDPLHELLEDL---------GELPTIPDLIGESIAADGHT 1335 + H LL E + PL +L D+ G+LP DL S G + Sbjct: 591 SLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDL--ASTPGSGSS 648 Query: 1336 DLSKLEVSLTLTNKFEGL 1353 +S + + N GL Sbjct: 649 SISAGLQKMVIENDLSGL 666 >gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] Length = 1139 Score = 39.3 bits (90), Expect = 0.032 Identities = 42/200 (21%), Positives = 87/200 (43%), Gaps = 12/200 (6%) Query: 1169 KVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQ 1228 +++ L+ RFL PA+++P F+++ + L +A+++Q+ A F + Sbjct: 471 RLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTS----RTLTLIAKVIQNLANFAKFGNK 526 Query: 1229 SQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDM---VAVAKPMVYITVGE 1285 +++ +ND+LE ++F+ D Y D+ ++V +++ V + Sbjct: 527 EEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQ 586 Query: 1286 LVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIAADGHTDLSKLEVSLT 1345 L L Q +A PL +L D+ + T P I + + + S VS + Sbjct: 587 LDKGENSFL--QATVA--KLGPLPRVLADITKSLTNPTPIQQQLRRFTEHN-SSPNVSGS 641 Query: 1346 LTNKFEGLEADADDSNTRSL 1365 L++ + + D DS+ L Sbjct: 642 LSSGLQKIFEDPTDSDLHKL 661 >gi|215982794 myosin VA isoform 2 [Homo sapiens] Length = 1828 Score = 38.9 bits (89), Expect = 0.041 Identities = 54/226 (23%), Positives = 110/226 (48%), Gaps = 27/226 (11%) Query: 735 IQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAI 794 I++Q +RG+L+R+K+ A I +Q + RGY Q + Y ++L+ KA A Sbjct: 771 IRIQKTIRGWLLRKKYLR-------MRKAAITMQRYVRGY-QARCYAKFLRRTKA---AT 819 Query: 795 IKIQAWARMWAARRQY-LRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSV 853 I IQ + RM+ RR+Y +RR + + +Q++ R A++ YR ++ H + + Sbjct: 820 I-IQKYWRMYVVRRRYKIRRA--------ATIVLQSYLRGFLARNRYRKILR-EHKAVII 869 Query: 854 VRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQ 913 +R L ++ + + + R++ + ++L++ L I + K I ++ Sbjct: 870 QKRVRGWL--ARTHYKRSMHAIIYLQCCFRRMMAKRELKK-LKIEARSVERYKKLHIGME 926 Query: 914 -EVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEK-RQKLEAYQ 957 +++ +K+ ++NK+ + L +G+ + EK R LE Q Sbjct: 927 NKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQ 972 >gi|215982791 myosin VA isoform 1 [Homo sapiens] Length = 1855 Score = 38.9 bits (89), Expect = 0.041 Identities = 54/226 (23%), Positives = 110/226 (48%), Gaps = 27/226 (11%) Query: 735 IQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAI 794 I++Q +RG+L+R+K+ A I +Q + RGY Q + Y ++L+ KA A Sbjct: 771 IRIQKTIRGWLLRKKYLR-------MRKAAITMQRYVRGY-QARCYAKFLRRTKA---AT 819 Query: 795 IKIQAWARMWAARRQY-LRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSV 853 I IQ + RM+ RR+Y +RR + + +Q++ R A++ YR ++ H + + Sbjct: 820 I-IQKYWRMYVVRRRYKIRRA--------ATIVLQSYLRGFLARNRYRKILR-EHKAVII 869 Query: 854 VRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQ 913 +R L ++ + + + R++ + ++L++ L I + K I ++ Sbjct: 870 QKRVRGWL--ARTHYKRSMHAIIYLQCCFRRMMAKRELKK-LKIEARSVERYKKLHIGME 926 Query: 914 -EVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEK-RQKLEAYQ 957 +++ +K+ ++NK+ + L +G+ + EK R LE Q Sbjct: 927 NKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQ 972 >gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] Length = 845 Score = 38.5 bits (88), Expect = 0.054 Identities = 29/91 (31%), Positives = 48/91 (52%), Gaps = 7/91 (7%) Query: 57 ELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAH- 115 EL ++LR+GVLL +L + P + L+++ LR Q + F NI +LS Sbjct: 32 ELAQALRDGVLLCQLLNNLLPHAINLREV----NLRPQMS--QFLCLKNIRTFLSTCCEK 85 Query: 116 IGLPSTFFPETTDIYDKKNMPRVVYCIHALS 146 GL + E D++D ++ +V+Y + ALS Sbjct: 86 FGLKRSELFEAFDLFDVQDFGKVIYTLSALS 116 >gi|4507357 transgelin 2 [Homo sapiens] Length = 199 Score = 38.5 bits (88), Expect = 0.054 Identities = 30/121 (24%), Positives = 59/121 (48%), Gaps = 14/121 (11%) Query: 21 MDEQRRQNVAYQYLCRLEEAK-RWMEACLKEELPSPVELEESLRN----GVLLAKLGHCF 75 + + +Q + QY LE+ +W+ ++++ P E+ +N G +L +L + Sbjct: 10 LSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINAL 69 Query: 76 APS-VVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKKN 134 P P+KKI QA+ + F+ + I+ +L A G+ +T +T D+++ KN Sbjct: 70 YPEGQAPVKKI--------QASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKN 121 Query: 135 M 135 M Sbjct: 122 M 122 >gi|122937512 myosin VIIB [Homo sapiens] Length = 2116 Score = 38.5 bits (88), Expect = 0.054 Identities = 35/118 (29%), Positives = 53/118 (44%), Gaps = 20/118 (16%) Query: 735 IQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAI 794 + +Q LRG+ R++F A + +QA WRGY R+ + L F+ L AI Sbjct: 768 LSIQKVLRGYRYRKEFLRQRR-------AAVTLQAWWRGYCNRRNFKLILVGFE-RLQAI 819 Query: 795 IKIQAWARMWAARRQ-----------YLRRLHYFQKNVNSIVKIQAFFRARKAQDDYR 841 + Q AR + A RQ YL R Q ++V IQA R A+ +++ Sbjct: 820 ARSQPLARQYQAMRQRTVQLQALCRGYLVR-QQVQAKRRAVVVIQAHARGMAARRNFQ 876 Score = 35.4 bits (80), Expect = 0.46 Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 11/99 (11%) Query: 735 IQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAI 794 +QLQA RG+LVRQ+ ++ AV+ IQAH RG R+ + Q KAN + Sbjct: 837 VQLQALCRGYLVRQQ-------VQAKRRAVVVIQAHARGMAARRNF----QQRKANAPLV 885 Query: 795 IKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRA 833 I + A + R ++ + + K+ F A Sbjct: 886 IPAEGQKSQGALPAKKRRSIYDTVTDTEMVEKVFGFLPA 924 >gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] Length = 1280 Score = 38.1 bits (87), Expect = 0.070 Identities = 44/201 (21%), Positives = 86/201 (42%), Gaps = 21/201 (10%) Query: 1169 KVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQ 1228 +++ L+ RFL PA+++P F+++ + L +A+++Q+ A F + Sbjct: 619 RLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTS----RTLTLIAKVIQNLANFAKFGNK 674 Query: 1229 SQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVG-ELV 1287 +++ +ND+LE ++F+ ++ P+ + YI +G EL Sbjct: 675 EEYMAFMNDFLEHEWGGMKRFL---LEISNPDTISNTPGFDG---------YIDLGRELS 722 Query: 1288 NTHRLLLE---HQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIAADGHTDLSKLEVSL 1344 H LL E D PL +L D+ + T P I + + + S VS Sbjct: 723 VLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHN-SSPNVSG 781 Query: 1345 TLTNKFEGLEADADDSNTRSL 1365 +L++ + + D DS+ L Sbjct: 782 SLSSGLQKIFEDPTDSDLHKL 802 >gi|5454102 transforming, acidic coiled-coil containing protein 3 [Homo sapiens] Length = 838 Score = 38.1 bits (87), Expect = 0.070 Identities = 38/150 (25%), Positives = 71/150 (47%), Gaps = 22/150 (14%) Query: 814 LHYFQKNVNSIVKIQAFFRARKAQDDYRIL------VHAPHPPLS-VVRRFAHLLNQSQQ 866 L Y QK+++++VK Q++ R L +H + L ++ RF ++ Q+ + Sbjct: 637 LQYSQKDLDAVVKA--------TQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAME 688 Query: 867 DFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRN 926 + + EL K E+ + ++ QL DLN M+ L K +EV+ +K + Sbjct: 689 EVQKQKELSKA--EIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESL 746 Query: 927 KEQLSDMMVLDKQKG-----LKSLSKEKRQ 951 K+ + D + Q+G LK+ ++EK Q Sbjct: 747 KKCVEDYLARITQEGQRYQALKAHAEEKLQ 776 >gi|224451032 KIAA1683 isoform a [Homo sapiens] Length = 1367 Score = 37.7 bits (86), Expect = 0.092 Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 7/45 (15%) Query: 734 VIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRK 778 VI +QA +RG+L R++ +R W + IQA WRGYR R+ Sbjct: 1117 VITIQAGVRGYLARRR-------IRLWHRGAMVIQATWRGYRVRR 1154 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 37.7 bits (86), Expect = 0.092 Identities = 66/308 (21%), Positives = 124/308 (40%), Gaps = 44/308 (14%) Query: 871 EAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQL 930 +AE +LQ++ K + QL+ ++N + K L++ L E K+ + + E+L Sbjct: 392 KAEFKQLQQQREEKEQHGLQLQSEINQLHSK---LLETERQLGEAHGRLKEQRQLSSEKL 448 Query: 931 SD--MMVLDKQKGLKSLSKEKRQKLEAYQHLFYLL-QTQPIYLAKLIFQMPQNKTTKFME 987 D V D Q L L ++ ++K+ L + L +T+ + + Q Q+ T K E Sbjct: 449 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ--QSTTAKLRE 506 Query: 988 A------VIFSLYNYASSRREAYLLLQLFKTAL------QEEIKSKVEQPQDVV------ 1029 A V+ + + + LLQ K + +E++ +K++ + Sbjct: 507 AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566 Query: 1030 -----TGNPTVVRLVVRFYRNGRGQSALQEILGKVIQD------VLEDKVLSVHTDPVHL 1078 T V +L + QE L +Q+ +D+VLS+ T L Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626 Query: 1079 ------YKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLA 1132 K ++Q + Q ++ L + ++Q LD A +N L + L Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA-QNALQDKQQELNK 685 Query: 1133 ITSSVDQI 1140 IT+ +DQ+ Sbjct: 686 ITTQLDQV 693 >gi|224451036 KIAA1683 isoform c [Homo sapiens] Length = 1134 Score = 37.7 bits (86), Expect = 0.092 Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 7/45 (15%) Query: 734 VIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRK 778 VI +QA +RG+L R++ +R W + IQA WRGYR R+ Sbjct: 884 VITIQAGVRGYLARRR-------IRLWHRGAMVIQATWRGYRVRR 921 >gi|54606862 KIAA1683 isoform b [Homo sapiens] Length = 1180 Score = 37.7 bits (86), Expect = 0.092 Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 7/45 (15%) Query: 734 VIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRK 778 VI +QA +RG+L R++ +R W + IQA WRGYR R+ Sbjct: 930 VITIQAGVRGYLARRR-------IRLWHRGAMVIQATWRGYRVRR 967 >gi|28269672 serologically defined colon cancer antigen 8 [Homo sapiens] Length = 713 Score = 37.7 bits (86), Expect = 0.092 Identities = 85/387 (21%), Positives = 147/387 (37%), Gaps = 42/387 (10%) Query: 130 YDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASE-----LAKYGL 184 +++ NMP + +H ++ + IH L +VKF EELS M ++ L GL Sbjct: 107 HEETNMPTMHDLVHTIN------DQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGL 160 Query: 185 QLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDT------------LAALQN 232 Q S+ E ++ +A+ + I + GV E + AA Sbjct: 161 QQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAG 220 Query: 233 PSALLENLR---EPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNIN 289 LE L+ E + + L + + A R +D + Q + +L A + Sbjct: 221 EQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280 Query: 290 HVNV-----HGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQ 344 + + L + Q+ E L+K D AL VR AD + S EQ Sbjct: 281 GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREA-SAYEQ 339 Query: 345 KAQELGLVELLEKEEVQAGVAAANTKGDQE-QAMLHAVQRINKAIRRGVAADTVKELMCP 403 Q L + E E+ +A + + + E QA + ++ +R + D +K+ + Sbjct: 340 VKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITK 399 Query: 404 EAQLPPVYPVASSMYQLELAVLQ-QQQGELGQEELFVAVEMLSAV--VLINRALEARDAS 460 E + + S M L + Q + Q E +E A+ L + L +R ++ Sbjct: 400 EREY-----MGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVC 454 Query: 461 GFWSSLVNPATGLAEVEGENAQRYFDA 487 G +N T + + E E R F A Sbjct: 455 GEMRYQLN-KTNMEKDEAEKEHREFRA 480 >gi|156119615 myosin IXA [Homo sapiens] Length = 2548 Score = 37.4 bits (85), Expect = 0.12 Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 10/100 (10%) Query: 711 QSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAH 770 + A +AA Q W+A++ L+ R +++QK+ + + R A I IQA Sbjct: 1069 KDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRD---YYRRRHMAAICIQAR 1125 Query: 771 WRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQY 810 W+ YR+ K Y E II +Q+ R + AR+++ Sbjct: 1126 WKAYRESKRYQE-------QRKKIILLQSTCRGFRARQRF 1158 >gi|189083802 myosin VIIA isoform 2 [Homo sapiens] Length = 2175 Score = 37.4 bits (85), Expect = 0.12 Identities = 46/184 (25%), Positives = 77/184 (41%), Gaps = 50/184 (27%) Query: 728 KANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY----LEW 783 KA VI LQ +RGF R F + + A IQ HWRG+ RK Y L + Sbjct: 742 KAITDRVILLQKVIRGFKDRSNFLKLKN-------AATLIQRHWRGHNCRKNYGLMRLGF 794 Query: 784 L------------QYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFF 831 L Q ++ II+ QA R + R+ + RL +++ +QA+ Sbjct: 795 LRLQALHRSRKLHQQYRLARQRIIQFQARCRAYLVRKAFRHRLW-------AVLTVQAYA 847 Query: 832 RARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKL-QEEVVRKIRSNQQ 890 R ++ R H +++ + EAE ++L +EE +RK S ++ Sbjct: 848 R-------------------GMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAKK 888 Query: 891 LEQD 894 +++ Sbjct: 889 AKEE 892 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.133 0.381 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 57,034,125 Number of Sequences: 37866 Number of extensions: 2449047 Number of successful extensions: 8181 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 20 Number of HSP's successfully gapped in prelim test: 104 Number of HSP's that attempted gapping in prelim test: 7785 Number of HSP's gapped (non-prelim): 402 length of query: 1631 length of database: 18,247,518 effective HSP length: 116 effective length of query: 1515 effective length of database: 13,855,062 effective search space: 20990418930 effective search space used: 20990418930 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.