BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens] (3667 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 7744 0.0 gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 7700 0.0 gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 6411 0.0 gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 4598 0.0 gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 3696 0.0 gi|148886654 polydom [Homo sapiens] 521 e-147 gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 410 e-113 gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 399 e-110 gi|54792123 complement component (3d/Epstein Barr virus) recepto... 353 2e-96 gi|42544177 complement component (3d/Epstein Barr virus) recepto... 345 5e-94 gi|157419154 selectin P precursor [Homo sapiens] 258 6e-68 gi|32261332 seizure related 6 homolog (mouse)-like precursor [Ho... 233 2e-60 gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens] 233 3e-60 gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens] 233 3e-60 gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ... 224 2e-57 gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ... 224 2e-57 gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [H... 224 2e-57 gi|22547221 tolloid-like 1 [Homo sapiens] 218 9e-56 gi|6912724 tolloid-like 2 [Homo sapiens] 213 2e-54 gi|187960042 selectin E precursor [Homo sapiens] 206 3e-52 gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 202 4e-51 gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 199 5e-50 gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 ... 194 1e-48 gi|62739186 complement factor H isoform a precursor [Homo sapiens] 193 3e-48 gi|4502503 complement component 4 binding protein, alpha chain p... 176 3e-43 gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 146 3e-34 gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 145 6e-34 gi|62739188 complement factor H isoform b precursor [Homo sapiens] 134 2e-30 gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr... 128 9e-29 gi|13899255 membrane frizzled-related protein [Homo sapiens] 125 1e-27 >gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens] Length = 3667 Score = 7744 bits (20092), Expect = 0.0 Identities = 3667/3667 (100%), Positives = 3667/3667 (100%) Query: 1 MWSWFLCWKPVQLDRQTASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEER 60 MWSWFLCWKPVQLDRQTASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEER Sbjct: 1 MWSWFLCWKPVQLDRQTASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEER 60 Query: 61 NRIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFA 120 NRIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFA Sbjct: 61 NRIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFA 120 Query: 121 VSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIA 180 VSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIA Sbjct: 121 VSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIA 180 Query: 181 NSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTIS 240 NSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTIS Sbjct: 181 NSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTIS 240 Query: 241 LIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSA 300 LIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSA Sbjct: 241 LIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSA 300 Query: 301 PYQGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTS 360 PYQGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTS Sbjct: 301 PYQGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTS 360 Query: 361 LRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFK 420 LRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFK Sbjct: 361 LRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFK 420 Query: 421 LFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQG 480 LFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQG Sbjct: 421 LFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQG 480 Query: 481 AKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITA 540 AKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITA Sbjct: 481 AKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITA 540 Query: 541 VNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLH 600 VNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLH Sbjct: 541 VNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLH 600 Query: 601 LQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEK 660 LQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEK Sbjct: 601 LQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEK 660 Query: 661 SIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIH 720 SIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIH Sbjct: 661 SIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIH 720 Query: 721 LSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGR 780 LSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGR Sbjct: 721 LSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGR 780 Query: 781 GFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDG 840 GFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDG Sbjct: 781 GFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDG 840 Query: 841 KVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF 900 KVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF Sbjct: 841 KVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF 900 Query: 901 QTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 960 QTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY Sbjct: 901 QTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 960 Query: 961 ESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPL 1020 ESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPL Sbjct: 961 ESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPL 1020 Query: 1021 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1080 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY Sbjct: 1021 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1080 Query: 1081 LLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE 1140 LLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE Sbjct: 1081 LLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE 1140 Query: 1141 PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1200 PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE Sbjct: 1141 PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1200 Query: 1201 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1260 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK Sbjct: 1201 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1260 Query: 1261 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1320 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP Sbjct: 1261 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1320 Query: 1321 QFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKG 1380 QFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKG Sbjct: 1321 QFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKG 1380 Query: 1381 ESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDM 1440 ESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDM Sbjct: 1381 ESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDM 1440 Query: 1441 LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRN 1500 LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRN Sbjct: 1441 LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRN 1500 Query: 1501 GDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFIL 1560 GDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFIL Sbjct: 1501 GDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFIL 1560 Query: 1561 SPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQD 1620 SPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQD Sbjct: 1561 SPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQD 1620 Query: 1621 SKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLG 1680 SKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLG Sbjct: 1621 SKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLG 1680 Query: 1681 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPK 1740 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPK Sbjct: 1681 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPK 1740 Query: 1741 NYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESL 1800 NYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESL Sbjct: 1741 NYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESL 1800 Query: 1801 PLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSV 1860 PLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSV Sbjct: 1801 PLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSV 1860 Query: 1861 LFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYD 1920 LFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYD Sbjct: 1861 LFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYD 1920 Query: 1921 NNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNS 1980 NNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNS Sbjct: 1921 NNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNS 1980 Query: 1981 TSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQ 2040 TSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQ Sbjct: 1981 TSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQ 2040 Query: 2041 GYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWT 2100 GYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWT Sbjct: 2041 GYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWT 2100 Query: 2101 INLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLY 2160 INLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLY Sbjct: 2101 INLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLY 2160 Query: 2161 FHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNS 2220 FHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNS Sbjct: 2161 FHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNS 2220 Query: 2221 ALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNG 2280 ALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNG Sbjct: 2221 ALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNG 2280 Query: 2281 IYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS 2340 IYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS Sbjct: 2281 IYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS 2340 Query: 2341 GFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLG 2400 GFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLG Sbjct: 2341 GFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLG 2400 Query: 2401 ERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFV 2460 ERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFV Sbjct: 2401 ERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFV 2460 Query: 2461 EFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGF 2520 EFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGF Sbjct: 2461 EFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGF 2520 Query: 2521 RIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW 2580 RIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW Sbjct: 2521 RIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW 2580 Query: 2581 DAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2640 DAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW Sbjct: 2581 DAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2640 Query: 2641 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL 2700 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL Sbjct: 2641 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL 2700 Query: 2701 PNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECL 2760 PNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECL Sbjct: 2701 PNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECL 2760 Query: 2761 SSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD 2820 SSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD Sbjct: 2761 SSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD 2820 Query: 2821 HNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ 2880 HNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ Sbjct: 2821 HNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ 2880 Query: 2881 WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN 2940 WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN Sbjct: 2881 WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN 2940 Query: 2941 GQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH 3000 GQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH Sbjct: 2941 GQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH 3000 Query: 3001 WSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG 3060 WSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG Sbjct: 3001 WSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG 3060 Query: 3061 SWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 3120 SWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT Sbjct: 3061 SWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 3120 Query: 3121 WSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT 3180 WSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT Sbjct: 3121 WSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT 3180 Query: 3181 WSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3240 WSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS Sbjct: 3181 WSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3240 Query: 3241 GEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGS 3300 GEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGS Sbjct: 3241 GEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGS 3300 Query: 3301 SPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3360 SPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS Sbjct: 3301 SPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3360 Query: 3361 GIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWT 3420 GIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWT Sbjct: 3361 GIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWT 3420 Query: 3421 GKVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTS 3480 GKVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTS Sbjct: 3421 GKVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTS 3480 Query: 3481 FNASTGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGF 3540 FNASTGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGF Sbjct: 3481 FNASTGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGF 3540 Query: 3541 VSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFF 3600 VSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFF Sbjct: 3541 VSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFF 3600 Query: 3601 ALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNL 3660 ALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNL Sbjct: 3601 ALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNL 3660 Query: 3661 NTVCTMV 3667 NTVCTMV Sbjct: 3661 NTVCTMV 3667 >gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens] Length = 3707 Score = 7700 bits (19979), Expect = 0.0 Identities = 3653/3666 (99%), Positives = 3653/3666 (99%), Gaps = 1/3666 (0%) Query: 3 SWFLCWKPV-QLDRQTASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERN 61 S F W V L GFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERN Sbjct: 42 SGFTFWNLVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERN 101 Query: 62 RIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAV 121 RIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAV Sbjct: 102 RIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAV 161 Query: 122 SAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN 181 SAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN Sbjct: 162 SAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN 221 Query: 182 SVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 241 SVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL Sbjct: 222 SVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 281 Query: 242 IFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAP 301 IFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAP Sbjct: 282 IFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAP 341 Query: 302 YQGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSL 361 YQGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSL Sbjct: 342 YQGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSL 401 Query: 362 RNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKL 421 RNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKL Sbjct: 402 RNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKL 461 Query: 422 FPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGA 481 FPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGA Sbjct: 462 FPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGA 521 Query: 482 KSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAV 541 KSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAV Sbjct: 522 KSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAV 581 Query: 542 NTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHL 601 NTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHL Sbjct: 582 NTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHL 641 Query: 602 QTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKS 661 QTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKS Sbjct: 642 QTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKS 701 Query: 662 IVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHL 721 IVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHL Sbjct: 702 IVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHL 761 Query: 722 SFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRG 781 SFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRG Sbjct: 762 SFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRG 821 Query: 782 FNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGK 841 FNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGK Sbjct: 822 FNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGK 881 Query: 842 VMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQ 901 VMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQ Sbjct: 882 VMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQ 941 Query: 902 TELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYE 961 TELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYE Sbjct: 942 TELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYE 1001 Query: 962 SVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLP 1021 SVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLP Sbjct: 1002 SVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLP 1061 Query: 1022 TCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYL 1081 TCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYL Sbjct: 1062 TCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYL 1121 Query: 1082 LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEP 1141 LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEP Sbjct: 1122 LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEP 1181 Query: 1142 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1201 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC Sbjct: 1182 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1241 Query: 1202 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1261 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD Sbjct: 1242 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1301 Query: 1262 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQ 1321 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQ Sbjct: 1302 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQ 1361 Query: 1322 FGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGE 1381 FGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGE Sbjct: 1362 FGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGE 1421 Query: 1382 SSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDML 1441 SSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDML Sbjct: 1422 SSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDML 1481 Query: 1442 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG 1501 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG Sbjct: 1482 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG 1541 Query: 1502 DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILS 1561 DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILS Sbjct: 1542 DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILS 1601 Query: 1562 PNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDS 1621 PNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDS Sbjct: 1602 PNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDS 1661 Query: 1622 KLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGS 1681 KLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGS Sbjct: 1662 KLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGS 1721 Query: 1682 TVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKN 1741 TVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKN Sbjct: 1722 TVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKN 1781 Query: 1742 YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLP 1801 YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLP Sbjct: 1782 YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLP 1841 Query: 1802 LSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVL 1861 LSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVL Sbjct: 1842 LSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVL 1901 Query: 1862 FDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDN 1921 FDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDN Sbjct: 1902 FDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDN 1961 Query: 1922 NLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNST 1981 NLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNST Sbjct: 1962 NLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNST 2021 Query: 1982 SNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQG 2041 SNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQG Sbjct: 2022 SNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQG 2081 Query: 2042 YSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTI 2101 YSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTI Sbjct: 2082 YSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTI 2141 Query: 2102 NLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF 2161 NLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF Sbjct: 2142 NLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF 2201 Query: 2162 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSA 2221 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSA Sbjct: 2202 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSA 2261 Query: 2222 LTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI 2281 LTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI Sbjct: 2262 LTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI 2321 Query: 2282 YINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSG 2341 YINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSG Sbjct: 2322 YINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSG 2381 Query: 2342 FFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2401 FFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE Sbjct: 2382 FFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2441 Query: 2402 RLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVE 2461 RLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVE Sbjct: 2442 RLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVE 2501 Query: 2462 FFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR 2521 FFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR Sbjct: 2502 FFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR 2561 Query: 2522 IRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2581 IRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD Sbjct: 2562 IRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2621 Query: 2582 APVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2641 APVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS Sbjct: 2622 APVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2681 Query: 2642 NHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLP 2701 NHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLP Sbjct: 2682 NHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLP 2741 Query: 2702 NGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLS 2761 NGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLS Sbjct: 2742 NGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLS 2801 Query: 2762 SGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH 2821 SGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH Sbjct: 2802 SGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH 2861 Query: 2822 NWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQW 2881 NWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQW Sbjct: 2862 NWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQW 2921 Query: 2882 SHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG 2941 SHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG Sbjct: 2922 SHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG 2981 Query: 2942 QWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW 3001 QWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW Sbjct: 2982 QWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW 3041 Query: 3002 SGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 3061 SGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGS Sbjct: 3042 SGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 3101 Query: 3062 WTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTW 3121 WTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTW Sbjct: 3102 WTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTW 3161 Query: 3122 SGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTW 3181 SGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTW Sbjct: 3162 SGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTW 3221 Query: 3182 SGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSG 3241 SGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSG Sbjct: 3222 SGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSG 3281 Query: 3242 EVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSS 3301 EVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSS Sbjct: 3282 EVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSS 3341 Query: 3302 PHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSG 3361 PHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSG Sbjct: 3342 PHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSG 3401 Query: 3362 IQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTG 3421 IQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTG Sbjct: 3402 IQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTG 3461 Query: 3422 KVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTSF 3481 KVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTSF Sbjct: 3462 KVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTSF 3521 Query: 3482 NASTGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFV 3541 NASTGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFV Sbjct: 3522 NASTGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFV 3581 Query: 3542 SAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFA 3601 SAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFA Sbjct: 3582 SAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFA 3641 Query: 3602 LIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNLN 3661 LIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNLN Sbjct: 3642 LIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNLN 3701 Query: 3662 TVCTMV 3667 TVCTMV Sbjct: 3702 TVCTMV 3707 >gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sapiens] Length = 3538 Score = 6411 bits (16633), Expect = 0.0 Identities = 3074/3271 (93%), Positives = 3110/3271 (95%), Gaps = 83/3271 (2%) Query: 406 HRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLG 465 ++VKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLG Sbjct: 342 YQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLG 401 Query: 466 STVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFP 525 STVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFP Sbjct: 402 STVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFP 461 Query: 526 FQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSF 585 FQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSF Sbjct: 462 FQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSF 521 Query: 586 VPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDV 645 VPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDV Sbjct: 522 VPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDV 581 Query: 646 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 705 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL Sbjct: 582 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 641 Query: 706 NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSH 765 NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSH Sbjct: 642 NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSH 701 Query: 766 ILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFI 825 ILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFI Sbjct: 702 ILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFI 761 Query: 826 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 885 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVI Sbjct: 762 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 821 Query: 886 EAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLF 945 EAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLF Sbjct: 822 EAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLF 881 Query: 946 TTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHE 1005 TTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHE Sbjct: 882 TTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHE 941 Query: 1006 EPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1065 EPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV Sbjct: 942 EPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1001 Query: 1066 QFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSI 1125 QFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSI Sbjct: 1002 QFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSI 1061 Query: 1126 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG 1185 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG Sbjct: 1062 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG 1121 Query: 1186 GRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISART 1245 GRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISART Sbjct: 1122 GRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISART 1181 Query: 1246 FHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLV 1305 FHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLV Sbjct: 1182 FHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLV 1241 Query: 1306 YTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDY 1365 YTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDY Sbjct: 1242 YTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDY 1301 Query: 1366 PLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS 1425 PLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS Sbjct: 1302 PLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS 1361 Query: 1426 HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVA 1485 HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVA Sbjct: 1362 HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVA 1421 Query: 1486 TACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1545 TACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI Sbjct: 1422 TACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1481 Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY Sbjct: 1482 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1541 Query: 1606 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPG 1665 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPG Sbjct: 1542 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPG 1601 Query: 1666 NIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSR 1725 NIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSR Sbjct: 1602 NIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSR 1661 Query: 1726 STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQS 1785 STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQS Sbjct: 1662 STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQS 1721 Query: 1786 SLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPR 1845 SLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPR Sbjct: 1722 SLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPR 1781 Query: 1846 FGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTK 1905 FGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTK Sbjct: 1782 FGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTK 1841 Query: 1906 RKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPR 1965 RKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPR Sbjct: 1842 RKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPR 1901 Query: 1966 LGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIG 2025 LGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIG Sbjct: 1902 LGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIG 1961 Query: 2026 DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSP 2085 DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSP Sbjct: 1962 DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSP 2021 Query: 2086 GFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQ 2145 GFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQ Sbjct: 2022 GFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQ 2081 Query: 2146 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQT 2205 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQT Sbjct: 2082 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQT 2141 Query: 2206 ISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPN 2265 ISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPN Sbjct: 2142 ISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPN 2201 Query: 2266 FQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYST 2325 FQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYST Sbjct: 2202 FQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYST 2261 Query: 2326 SNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLP 2385 SNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLP Sbjct: 2262 SNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLP 2321 Query: 2386 GFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCA 2445 GFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCA Sbjct: 2322 GFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCA 2381 Query: 2446 WSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEV 2505 WSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSP V Sbjct: 2382 WSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSP---------------------V 2420 Query: 2506 FLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGK 2565 + S D+ + + I+ G ++ ++W+ D G G Sbjct: 2421 LISLSGDYSS----------------------AFNITSNGHEV--FLQWSADHGNNKKGF 2456 Query: 2566 SSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILT-TDYLVGTRVTYFCNDGYRL 2624 A C P++P +G I++ T + + V + C+ G+RL Sbjct: 2457 RIRYI------------------AFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRL 2498 Query: 2625 SSKELTTAVCQ--SDGTWSNHNKTPRCVVVTC----PSINSFILEHGRWRIVNGSHYEYK 2678 K ++AVC+ S G + P C ++C N IL + Y Sbjct: 2499 VGK--SSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILT---------TDYLVG 2547 Query: 2679 TKVVFSCDPGYHGLGP--ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTS 2736 T+V + C+ GY + C +GTWS N+ P C +ISCGELPTPPNGNKIGTQTS Sbjct: 2548 TRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGTQTS 2607 Query: 2737 YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYR 2796 YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYR Sbjct: 2608 YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYR 2667 Query: 2797 DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDV 2856 DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDV Sbjct: 2668 DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDV 2727 Query: 2857 VTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2916 VTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG Sbjct: 2728 VTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2787 Query: 2917 TVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGST 2976 TVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGST Sbjct: 2788 TVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGST 2847 Query: 2977 VHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKS 3036 VHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKS Sbjct: 2848 VHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKS 2907 Query: 3037 TVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSS 3096 TVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSS Sbjct: 2908 TVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSS 2967 Query: 3097 VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVS 3156 VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVS Sbjct: 2968 VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVS 3027 Query: 3157 YMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSIS 3216 YMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSIS Sbjct: 3028 YMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSIS 3087 Query: 3217 YICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFS 3276 YICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFS Sbjct: 3088 YICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFS 3147 Query: 3277 CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQ 3336 CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQ Sbjct: 3148 CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQ 3207 Query: 3337 FHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIY 3396 FHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIY Sbjct: 3208 FHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIY 3267 Query: 3397 TCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFA 3456 TCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFA Sbjct: 3268 TCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFA 3327 Query: 3457 QNYIWKGSYNFKGRKQPMTLTVTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLRI 3516 QNYIWKGSYNFKGRKQPMTLTVTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLRI Sbjct: 3328 QNYIWKGSYNFKGRKQPMTLTVTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLRI 3387 Query: 3517 YLIKVPAHASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEG 3576 YLIKVPAHASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEG Sbjct: 3388 YLIKVPAHASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEG 3447 Query: 3577 SNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAA 3636 SNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAA Sbjct: 3448 SNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAA 3507 Query: 3637 FENPMYDTNAKSVEGKAVRFDPNLNTVCTMV 3667 FENPMYDTNAKSVEGKAVRFDPNLNTVCTMV Sbjct: 3508 FENPMYDTNAKSVEGKAVRFDPNLNTVCTMV 3538 Score = 1280 bits (3312), Expect = 0.0 Identities = 783/2181 (35%), Positives = 1137/2181 (52%), Gaps = 124/2181 (5%) Query: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 + TCG L+G +GT SP FP+ Y + A C WVI A N+ IQI F+ F LE YD L+ Sbjct: 62 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNR-IQIVFQSFALEEEYDYLS 120 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 + DG P LTG +P + S S L L +D +V + GFKV Y+E++ SC Sbjct: 121 LYDGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSC 178 Query: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENN----QWSANIPICIF- 679 G+PG P G+ G F D +R+ C G+ L G + C N+ W +PIC Sbjct: 179 GNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE 238 Query: 680 -PCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVK 738 C G + SP +P Y NN +C WTI+++PG I L F DF +E ++D+L ++ Sbjct: 239 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIE 298 Query: 739 DGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY------------ 786 + P +G +P + SN + LRL F D + RGF+ Y Sbjct: 299 GSEPPTI----WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRG 354 Query: 787 ----------NTF----------GHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIK 826 N F N CPDPG P N +R G +F LGS++ C+E ++ Sbjct: 355 FKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYV- 413 Query: 827 TQGTETITC-ILMDGKVMWSGLIPKCGA-PCGGHFSAPSGVILSPGWPGYYKDSLNCEWV 884 QG ++ITC + + WS P C CG + PSG SP +P Y + C WV Sbjct: 414 LQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWV 473 Query: 885 IEA-EPGHSIKITFERFQTELNYDVLEVHDGPNLLSP--LLGSYNGTQVPQFLFSSSNFI 941 I A I+I FE F E+ YD L + DG + P +L G+ VP + S S+ + Sbjct: 474 ITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQM 533 Query: 942 YLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYR 1001 +L TD S + GFK++Y+ + SC DPG P++G R G FS + F C G+ Sbjct: 534 WLHLQTDESVGSVGFKVNYKE--IEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFE 591 Query: 1002 LSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTH 1061 L E+ ++C++N+ WS +P C C + P GT+LSP YPE Y N+LNC WT+ Sbjct: 592 LIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDP 651 Query: 1062 GKGVQFNFHTFHLEDHHDYLLITENGSFTQP-LARLTGSDLPPTINAGLYGNFRAQLRFI 1120 G + +F+ F LE D+L + + S P L TG+++P + + + +L F Sbjct: 652 GSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTS---NSHILRLEFQ 708 Query: 1121 SDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGY-RLEGTSE 1179 +D S+S GFNIT++ + C DPGIP R G NF +G +++ C G+ + +GT Sbjct: 709 ADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTET 768 Query: 1180 IIC-LGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKG 1238 I C L G+ +WS +P+C A CG + G++LSP +P Y+++ C + I+ + G Sbjct: 769 ITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 828 Query: 1239 INISARTFHLAQG-DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEG 1297 I I+ F DVL+++DG + + LLG++ G + L S+SN ++L F +D Sbjct: 829 IKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQF-LFSSSNFIYLLFTTDNSR 887 Query: 1298 TDEGFQLVYTSFELS--HCEDPGIPQFGYKISDQGH--FAGSTIIYGCNPGYTLHGSSLL 1353 ++ GF++ Y S ++ C DPGIP G + GH GST+ + C+ GY L L Sbjct: 888 SNNGFKIHYESVTVNTYSCLDPGIPVHGRR---YGHDFSIGSTVSFSCDSGYRLSHEEPL 944 Query: 1354 KCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIV 1413 C + W +PLP+C A CGG +G SG ILSPGYP Y N+L C W ++V G V Sbjct: 945 LC--EKNHWWSHPLPTCDALCGGDVRG-PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1001 Query: 1414 SLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLN---IVTIQFDTDFY 1470 F F E HD L + + L + ++GS +P I++ L ++F +DF Sbjct: 1002 QFNFHTFHLEDHHDYLLITENGSFTQPLAR-LTGSDLPPTINAGLYGNFRAQLRFISDFS 1060 Query: 1471 ISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQ 1530 IS GF I FS C DPG+P G+R G GDT+ F C GY L+G I C+ Sbjct: 1061 ISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLG 1120 Query: 1531 VENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAF 1590 R W P C+A CG + T + G +LSPN+P Y ++ +C ++I V A I+++ Sbjct: 1121 -GGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISA 1179 Query: 1591 ISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPE-RIESSSNTMHLAFRSDGSVSYTGF 1649 +F + D L IYDG D + L+G+F + + + S+SN + L F SD + GF Sbjct: 1180 RTFHLAQG-DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGF 1238 Query: 1650 HLEYKAKLRESCFDPGNIMNGTRLG-MDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGR 1708 L Y + C DPG G ++ + GST+ Y C+ GY L G S L C+ G+ R Sbjct: 1239 QLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGE--R 1296 Query: 1709 PGWNRALPSCHAPCGSRSTG-SEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFF 1767 W+ LPSC A CG R G S G +LSP YP Y C++ I V +V QF+ F Sbjct: 1297 RAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAF 1356 Query: 1768 QT-SLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFV 1826 T + HD++ V+DGP + LL +SGS E + S+ N +TI+F + I+ GF Sbjct: 1357 DTEASHDILRVWDGPPENDMLLKEISGSLIPEGIH-STLNIVTIQFDTDFYISKSGFAIQ 1415 Query: 1827 YQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLA 1886 + + + +T C P G R G+ G +V+F C+PGY L G I C V N Sbjct: 1416 FSS---SVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYF 1472 Query: 1887 QWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFAT 1946 W S P CI PCGG LT G ILSP +P PY ++ +C W ITV I + +SF+ Sbjct: 1473 -WQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSI 1531 Query: 1947 EHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA 2006 E N+D L YDG D+N+P +GS+ + +P + S+SN ++L F+SD SVS GFHLEY A Sbjct: 1532 EPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1591 Query: 2007 IGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRR--WNYPI 2064 +SC +P +G ++G Y +G V++ CD GY LQG+S +TC+ G R WN + Sbjct: 1592 KLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRAL 1651 Query: 2065 PICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDY 2124 P C A CG + G +LSP +P NY +C ++I +P F V QFV F T ++HD Sbjct: 1652 PSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQT-SLHDV 1710 Query: 2125 LEVRSGSSETSTVIGRLSGPQIPSSL-FSTTHETSLYFHSDYSQNKQGFHIVYQAY---- 2179 +EV G ++ S+++ LSG SL S+ ++ ++ F S +GFH VYQA Sbjct: 1711 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1770 Query: 2180 --QLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTC--LHGVSRNWNHP 2235 Q S P+PR R IGN+F VG ++ F+C PGY L G+ A+ C + WN Sbjct: 1771 STQCSSVPEPRFGRR---IGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDS 1827 Query: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYD 2295 LP C CGG +T GTI SPGYP+ Y N +C W + VP G GI + TE +D Sbjct: 1828 LPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWD 1887 Query: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGF-FVLSYHAYQLRV 2354 + +DG D N+P++G +SG T + STSN + + F SD + S F L Y A L Sbjct: 1888 SLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDS 1947 Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414 C P P P++ I D + +GD++ +QC G++L G++ +TC G + + P+C Sbjct: 1948 C-PEPQTPSSGIKI-GDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2005 Query: 2415 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2474 C D +GVILSPG+P +YP+ C W+I++ G+ + + F TE D L+V Sbjct: 2006 QC--GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2063 Query: 2475 YDGPNIQSPVLISLSGDY--SSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---C 2529 G + S V+ LSG SS F+ T HE L + +D+ NK+GF I Y A+ C Sbjct: 2064 RSGSSETSTVIGRLSGPQIPSSLFSTT---HETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2120 Query: 2530 STPESPPHGYIISQ--TGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587 P +G++I T GQ + + C G+ L+G S+ C W+ P+P C Sbjct: 2121 PDPRPFRNGFVIGNDFTVGQ---TISFECFPGYTLIGNSALTCLHGV--SRNWNHPLPRC 2175 Query: 2588 QAISCGIPKAPTNGGILTTDY 2608 +A+ CG NG I + Y Sbjct: 2176 EAL-CGGNITAMNGTIYSPGY 2195 Score = 1077 bits (2786), Expect = 0.0 Identities = 859/2907 (29%), Positives = 1253/2907 (43%), Gaps = 325/2907 (11%) Query: 22 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 I+ C GT+ SP +P GY N NC W II++ +RI + F F LE ++D+L++ Sbjct: 614 IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAV 673 Query: 82 YDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNP 141 DG + TG +P +TS + L +D ++S GF + Y + C +P Sbjct: 674 KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDP 733 Query: 142 GVPPKGVLYGTRFDVGDKIRYSCVTGYI-LDGHPQLTCIANSVNTASWDFPVPICRAEDA 200 G+P +G F +G I C G+I G +TCI W +P C A Sbjct: 734 GIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMD-GKVMWSGLIPKCGA--P 790 Query: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGS 260 CGG SG+I SP +P Y ++ +C W I AEPG +I + F FQ E YD LE+ Sbjct: 791 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDG 850 Query: 261 ----EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGE 316 P +G +P + S+ N++ L F TD++ GF Y+ + T++ Sbjct: 851 PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPG 910 Query: 317 LEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTSKDGLS 376 + H R ++ ST S + + +RLS E+ + + + P + D L Sbjct: 911 IPVHGRRYGHDFSIGST------VSFSCDSGYRLSHEEPL-LCEKNHWWSHPLPTCDALC 963 Query: 377 ----PHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSNKFS 432 P+ T + P VTH K + F F L ++ + + Sbjct: 964 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTH--GKGVQFNFHTFHL----EDHHDYL 1017 Query: 433 ILNEGGI-------KTASNLCPDPGEPENGK-----RIGSDFSL---------------- 464 ++ E G T S+L P G R SDFS+ Sbjct: 1018 LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEP 1077 Query: 465 ---------GSTVQF----------SCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 GS + F SC Y L+G I C + WS P C V Sbjct: 1078 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIIC--LGGGRRVWSAPLPRC-V 1134 Query: 506 KTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTI 565 CG++ G SPN+P Y++N +C++ I V K I I+ F L G D L I Sbjct: 1135 AECGASATNNEGILLSPNYPLNYENNHECIYSI-QVQAGKGINISARTFHLAQG-DVLKI 1192 Query: 566 GDGGEVGDPRTVLQVLTGSFVPDL-IVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 DG + +L TG+ + L + S S+Q+WL +D GF++ Y E C Sbjct: 1193 YDGKD--KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHC 1250 Query: 625 GDPGTPLYGIREGD-GFSNRDVLRFECQFGFELIGEKSIVCQ--ENNQWSANIPICIFPC 681 DPG P +G + D G + + C G+ L G + C E W +P CI C Sbjct: 1251 EDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAEC 1310 Query: 682 LSNFTA-PMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDG 740 F G +LSP YP Y NNL C+W I DPG+ + L F FD E+ D L V DG Sbjct: 1311 GGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDG 1370 Query: 741 DSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 800 +L +G+ +P + S +I+ ++F D +S GF I +++ C DPG+P Sbjct: 1371 PPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1430 Query: 801 INARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFS 860 +N R GD + G ++ C+ G+ + QG E ITCI ++ + W P C APCGG+ + Sbjct: 1431 MNGTRNGDGREPGDTVVFQCDPGY-ELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLT 1489 Query: 861 APSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSP 920 SG ILSP +P Y S +C+W I + I + F F E NYD L ++DGP+ SP Sbjct: 1490 GSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSP 1549 Query: 921 LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGR 980 L+GS+ +++P+ + SSSN ++L F +D S S GF + Y++ SC DPG ++G Sbjct: 1550 LIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKL--RESCFDPGNIMNGT 1607 Query: 981 RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC----EKNHWWSHPLPTCDALCGGDVRGPSG 1036 R G D+ +GSTV++ CD+GY L L C + W+ LP+C A CG G G Sbjct: 1608 RLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEG 1667 Query: 1037 TILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI----TENGSFTQP 1092 T+LSP YP+ Y NC +++ V + V F F HD + + T+ S Sbjct: 1668 TVLSPNYPKNYSVGHNCVYSIAVPK-EFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSS 1726 Query: 1093 LA-RLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFS---EYNLEPCEDPGIP 1148 L+ +G LP L + +RF S I+ +GF+ + + C P Sbjct: 1727 LSGSHSGESLP------LSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEP 1780 Query: 1149 QYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIIC--LGGGRRVWSAPLPRCVAECGASAT 1206 ++G RIG F +G ++ F C+ GY L G+ I C + W+ LP C+ CG T Sbjct: 1781 RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILT 1840 Query: 1207 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-DVLKIYDGKDKTTH 1265 +G +LSP YP Y+NN C++ I V G GI + +F D L YDG D Sbjct: 1841 KRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAP 1900 Query: 1266 LLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYK 1325 LG+++G ++ L L+STSN L+L F SD + GF L YT+ L C +P P G K Sbjct: 1901 RLGSYSGTTIPHL-LNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIK 1959 Query: 1326 ISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGR 1385 I D+ + G + + C+ GY+L G S + CM G R W+YP+P C+A+CGG + SG Sbjct: 1960 IGDR-YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM-SDFSGV 2017 Query: 1386 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEI 1445 ILSPG+P Y ++L C W I + G V LQF+ F TE HD L V G E ++ + Sbjct: 2018 ILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRL 2077 Query: 1446 SGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGRE 1505 SG IP + ST + ++ F +D+ +K GF I + + +C DP NG G+ Sbjct: 2078 SGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFT 2137 Query: 1506 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFP 1565 G T+ F+C PGY L G +TC+ +R W P C A CGGN+T +G I SP +P Sbjct: 2138 VGQTISFECFPGYTLIGNSALTCLHGVSRN-WNHPLPRCEALCGGNITAMNGTIYSPGYP 2196 Query: 1566 HPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPE 1625 YP+ +DC W + V I + F EP YDF+ ++DGPD NSP IG F + E Sbjct: 2197 DEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALE 2256 Query: 1626 RIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMD--YKLGSTV 1683 + S+SN + + F SD + S F L Y A C P + N L D +++G + Sbjct: 2257 SVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDII 2315 Query: 1684 TYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRS--TGSEGTVLSPNYPKN 1741 Y C G+ L G + LTC +G+ R + A P C C + S G +LSP YP + Sbjct: 2316 RYQCLPGFTLVGNAILTCRLGE--RLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDS 2373 Query: 1742 YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLH-DVVEVYDGPTQQSSLLSSLSGSHSGESL 1800 Y C +SI+V K + + FFQT DV++VYDGP QS +L SLSG +S Sbjct: 2374 YPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFN 2433 Query: 1801 PLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFA-VGSS 1859 S+G+++ +++++ KGF Y A CS+ P G I + S Sbjct: 2434 ITSNGHEVFLQWSADHGNNKKGFRIRYIAF------YCSTPESPPHGYIISQTGGQLNSV 2487 Query: 1860 VLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEP 1918 V + C+ G+ L G + C W+ +P C + CG G IL+ Y Sbjct: 2488 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYL-- 2545 Query: 1919 YDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLL 1978 + +V F N+ RL S TT Sbjct: 2546 ------------------VGTRVTYFC---------------NDGYRLSSKELTTAVCQS 2572 Query: 1979 NSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQC 2038 + T +N H + + SC E TP +G KIG + G F C Sbjct: 2573 DGTWSN----------------HNKTPRCVVISCGELPTPPNGNKIGTQTSYGSTAIFTC 2616 Query: 2039 DQGYSLQGHSHITCMPGPVRRWNYPIPICLA-QCGGAMSDFSGVILSPGFPGNYPSSLDC 2097 D G+ L G + C+ + W+ CLA CG +G ++ + C Sbjct: 2617 DLGFMLVGSAVRECLSSGL--WSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQC 2674 Query: 2098 TWTINLPIGFGVHL--QFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTH 2155 L IG V + Q N+S + + + V G S + GR SG + T Sbjct: 2675 NPGFRL-IGSSVRICQQDHNWSGQ-LPSCVPVSCG-HPGSPIYGRTSGNGFNFNDVVTFS 2731 Query: 2156 ETSLYF-----HSDYSQNKQGFHIVYQAYQLQSCPDP----RPFRNGFVIGNDFTVGQTI 2206 Y + N+Q H ++ +C DP R + +FT G + Sbjct: 2732 CNIGYLMQGPTKAQCQANRQWSHPPPMC-KVVNCSDPGIPANSKRESKIEHGNFTYGTVV 2790 Query: 2207 SFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPDEYPN 2265 ++C PGY L G+S L C + W+ PLP C + CG PG P PN Sbjct: 2791 FYDCNPGYFLFGSSVLIC--QPNGQWDKPLPECIMIDCG-----------HPGVP---PN 2834 Query: 2266 FQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYST 2325 VL E TV +GQ S L +S Sbjct: 2835 --------------------AVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSG 2874 Query: 2326 SNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLP 2385 S H +G C P + ++ F +RY C Sbjct: 2875 SQP-----HCSGDATG------------TCGDPGTPGHGS--RQESNFRTKSTVRYACDT 2915 Query: 2386 GFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANE--------LRLD----STGVILS-- 2431 G+ L G+ TC G P C+ + N R+D S+ VI S Sbjct: 2916 GYILHGSEERTCLANG--SWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCM 2973 Query: 2432 PGYPDSYPNLQMC----AWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLIS 2487 GY S P+++ C WS ++ N T+ + + L+ D + V Sbjct: 2974 EGYILSGPSVRQCTANGTWSGTLP---NCTI-ISCGDPGIPANGLRYGDDYVVGQNVSYM 3029 Query: 2488 LSGDYSSAFN------ITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYII 2541 Y+ N T NG WS G A C TP +G + Sbjct: 3030 CQPGYTMELNGSRIRTCTING-----TWS--------GVMPTCRAVTCPTPPQISNGR-L 3075 Query: 2542 SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNG 2601 T + + C G+ L + C G W VP C CG P P G Sbjct: 3076 EGTNFDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKFCGDPGIPAQG 3131 Query: 2602 GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSI-NSF 2660 ++ + V++ CN + L +T +CQ+DGTWS +P C+ T S N Sbjct: 3132 KREGKSFIYQSEVSFSCNFPFILVGS--STRICQADGTWS--GSSPHCIEPTQTSCENPG 3187 Query: 2661 ILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCG 2720 + HG N ++ + V F C G+ G + CLP+ TWS +P C SC Sbjct: 3188 VPRHGSQN--NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS--GIQPECIPHSCK 3243 Query: 2721 ELPTPPNGNKIGTQ-TSYGSTAIFTCDLGFMLVGSAV-RECLSSGLWSESETRCLAGH-- 2776 + TP + N +G S+G T I+TC GF L G R C S W+ C AG Sbjct: 3244 QPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKI 3303 Query: 2777 ----------CGIPELIVNGQVIGENY 2793 P+L V V +NY Sbjct: 3304 LVKDPRPALGTPSPKLSVPDDVFAQNY 3330 Score = 841 bits (2172), Expect = 0.0 Identities = 702/2408 (29%), Positives = 1008/2408 (41%), Gaps = 366/2408 (15%) Query: 1201 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-DVLKIYDG 1259 CG + G + SP +P Y N C + I + I I ++F L + D L +YDG Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 124 Query: 1260 KDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGI 1319 T+ TG + ++ST + L SD + GF++ Y + S C +PG+ Sbjct: 125 HPHPTNFRTRLTGFHLPP-PVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGV 183 Query: 1320 PQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTG--ERRAWDYPLPSCIAE--CG 1375 P G + G I Y C GY L G L C+ +WD+P+P C AE CG Sbjct: 184 PPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACG 242 Query: 1376 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1435 G +G SSG I SP +P Y NN C W I +PG+ +SL F F E +D L + Sbjct: 243 GTMRG-SSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSE 301 Query: 1436 PENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGF--------AIQFSS----- 1482 P L SG IP I S N + + F TD GF AI F S Sbjct: 302 PPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKL 357 Query: 1483 -------------------SVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGE 1523 + + C DPG P NG R G G TV F CD Y LQG Sbjct: 358 FPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGA 417 Query: 1524 ERITCIQVENRY-FWQPSPPVC-IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTIT-V 1580 + ITC ++ + W PVC + CG NL G SG SPNFP Y + C W IT V Sbjct: 418 KSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAV 477 Query: 1581 NADYVISLAFISFSIEPNYDFLYIYDGPDSNSP------LIGSFQDSKLPERIESSSNTM 1634 N + VI + F F +E YD L I DG + P L GSF +P+ I S S+ M Sbjct: 478 NTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSF----VPDLIVSMSSQM 533 Query: 1635 HLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQ 1694 L ++D SV GF + YK +ESC DPG + G R G + + + C G+ L Sbjct: 534 WLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELI 593 Query: 1695 GYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYS-IA 1753 G ++ C + W+ +P C PC S T GTVLSP+YP+ Y NC+++ I+ Sbjct: 594 GEKSIVCQENNQ----WSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIIS 649 Query: 1754 VPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFT 1813 P + F S D + V DG + +S +L + +G+ L S+ + + + F Sbjct: 650 DPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHL-TSNSHILRLEFQ 708 Query: 1814 SVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYI-LHG 1872 + ++ +GF+ Y +C P RR G+ F +GSS+ C G+I G Sbjct: 709 ADHSMSGRGFNITYNTF---GHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQG 765 Query: 1873 SIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVP 1932 + I C + + W+ +P C PCGG + G ILSPG+P Y ++LNC W I Sbjct: 766 TETITC-ILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAE 824 Query: 1933 EGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSD 1992 G I++ F TE N+D L+ +DG + +P LGSY+GT +P L S+SN +YL F +D Sbjct: 825 PGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTD 884 Query: 1993 ISVSAAGFHLEYTAIGLD--SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHI 2050 S S GF + Y ++ ++ SC +P P G + G + +G VSF CD GY L + Sbjct: 885 NSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPL 944 Query: 2051 TCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVH 2110 C W++P+P C A CGG + SG ILSPG+P YP+SL+CTWT+++ G GV Sbjct: 945 LCEKN--HWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQ 1002 Query: 2111 LQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTH---ETSLYFHSDYSQ 2167 F F E HDYL + S T + RL+G +P ++ + + L F SD+S Sbjct: 1003 FNFHTFHLEDHHDYLLITENGSFTQP-LARLTGSDLPPTINAGLYGNFRAQLRFISDFSI 1061 Query: 2168 NKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHG 2227 + +GF+I + Y L+ C DP + G IG +F +G T++F C GY L G S + CL G Sbjct: 1062 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG 1121 Query: 2228 VSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTV 2287 R W+ PLPRC A CG + T G + SP YP Y N +C + ++V G GI I+ Sbjct: 1122 GRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISART 1181 Query: 2288 LQTEPIYDFITVWDGPDQNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFT-TSGFFVL 2345 D + ++DG D+ + +G F+G + ++ STSNQ+ ++F+SD T F L Sbjct: 1182 FHLAQ-GDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQL 1240 Query: 2346 SYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQM 2405 Y +++L C+ P +P D G I Y C PG+TL G+++L C GER Sbjct: 1241 VYTSFELSHCE-DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAW 1299 Query: 2406 DGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQT 2465 D P C C + +S+G ILSPGYP Y N C W I V+ G +++ F T Sbjct: 1300 DYPLPSCIAEC-GGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDT 1358 Query: 2466 EKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY- 2524 E D+L+V+DGP +L +SG I S + V +Q+ D +K GF I++ Sbjct: 1359 EASHDILRVWDGPPENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFS 1417 Query: 2525 --IAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDA 2582 +A C P P +G + G + V + CD G+ L G+ C + Y W Sbjct: 1418 SSVATACRDPGVPMNG-TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYF-WQP 1475 Query: 2583 PVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFC------NDGYRLSSKELTTAVCQS 2636 P C A CG ++G IL+ ++ + C N Y +S ++ ++ + Sbjct: 1476 SPPVCIA-PCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN 1534 Query: 2637 -------DGTWSN--------HNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKV 2681 DG SN +K P + + +++ G G H EYK K+ Sbjct: 1535 YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVS-YTGFHLEYKAKL 1593 Query: 2682 VFSC-DPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGST 2740 SC DPG NG ++G GST Sbjct: 1594 RESCFDPG-----------------------------------NIMNGTRLGMDYKLGST 1618 Query: 2741 AIFTCDLGFMLVGSAVRECLSSG----LWSESETRCLAGHCGIPELIVNGQVIGENYGYR 2796 + CD G++L G + C+ W+ + C A CG G V+ NY Sbjct: 1619 VTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKN 1677 Query: 2797 DTVVYQCNPG------------FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG 2844 +V + C F +S+ + ++ Q S + G Sbjct: 1678 YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLP 1737 Query: 2845 RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKR 2904 +SGN I + GP A + P CS P +R Sbjct: 1738 LSSGN----------QITIRFTSVGPITA--KGFHFVYQAVPRTSSTQCSSVPEPRFGRR 1785 Query: 2905 ESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQ--PN--GQWDKPLPECIMIDCG---- 2956 F G+ V +DCNPGY L GS + C+ PN QW+ LP CI + CG Sbjct: 1786 IG----NEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI-VPCGGILT 1840 Query: 2957 -------HPG----------------VPPNAVLSGEKYTFGSTVH--------------- 2978 PG VP A + + +F +T H Sbjct: 1841 KRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSF-ATEHNWDSLDFYDGGDNNA 1899 Query: 2979 -----YSCTGKRSLLGQSSRTCQLNGH----WSGSQPHCSGDATG--TCGDPGTPGHGSR 3027 YS T LL +S LN S + H A G +C +P TP G + Sbjct: 1900 PRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIK 1959 Query: 3028 QESNFRTKSTVRYACDTGYILHGSEERTCLAN--GSWTGRQPECKAVQCG---------- 3075 + V + CD GY L G TC+ W P C A QCG Sbjct: 1960 IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA-QCGGAMSDFSGVI 2018 Query: 3076 -NPGTTAN---------------GKVFRIDGTTFSSSVIYSCMEGYI-----------LS 3108 +PG N G + FS+ I+ +E LS Sbjct: 2019 LSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLS 2078 Query: 3109 GPSVRQCTANGTWSGTL-----------------PNCTIISCGDPGIPANGLRYGDDYVV 3151 GP + + T +L + SC DP NG G+D+ V Sbjct: 2079 GPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTV 2138 Query: 3152 GQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF 3209 GQ +S+ C PGYT L G+ TC ++ W+ +P C A + G + N Sbjct: 2139 GQTISFECFPGYT--LIGNSALTCLHGVSRNWNHPLPRCEA--------LCGGNITAMN- 2187 Query: 3210 DWGFSISYICSPGYELSFPAVLTCV-------GNG------------------TWSG--- 3241 I SPGY +P C GNG W G Sbjct: 2188 ------GTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQ 2241 Query: 3242 EVPQCLPKFCGDPGIPAQGKREGKSFI-YQSEVSFSCNFPFILVGSSTRICQADGTWSGS 3300 PQ + +F G+ + + + I + S+ + S F R+CQ Sbjct: 2242 NSPQ-IGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPP------ 2294 Query: 3301 SPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL--PDLT 3358 P VP F++G ++++ C G L G+ TC L Sbjct: 2295 --------------PPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQ 2340 Query: 3359 WSGIQPEC 3366 G P C Sbjct: 2341 MDGAPPVC 2348 Score = 608 bits (1567), Expect = e-173 Identities = 289/302 (95%), Positives = 289/302 (95%), Gaps = 1/302 (0%) Query: 3 SWFLCWKPV-QLDRQTASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERN 61 S F W V L GFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERN Sbjct: 42 SGFTFWNLVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERN 101 Query: 62 RIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAV 121 RIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAV Sbjct: 102 RIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAV 161 Query: 122 SAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN 181 SAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN Sbjct: 162 SAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN 221 Query: 182 SVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 241 SVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL Sbjct: 222 SVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 281 Query: 242 IFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAP 301 IFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAP Sbjct: 282 IFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAP 341 Query: 302 YQ 303 YQ Sbjct: 342 YQ 343 Score = 189 bits (480), Expect = 4e-47 Identities = 105/288 (36%), Positives = 149/288 (51%), Gaps = 13/288 (4%) Query: 22 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNR-IQIVFQSFALEEEYDYLS 80 + TCG L+G +GT SP FP+ Y + A C WVI A N+ IQI F+ F LE YD L+ Sbjct: 441 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 500 Query: 81 LYDGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSC 138 + DG P LTG +P + S S L L +D +V + GFKV Y+E++ SC Sbjct: 501 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 560 Query: 139 GNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE 198 G+PG P G+ G F D +R+ C G+ L G + C N+ W +PIC Sbjct: 561 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENN----QWSANIPICIF- 615 Query: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIE 258 C G + SP +P Y NN +C WTI+++PG I L F DF +E ++D+L ++ Sbjct: 616 -PCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVK 674 Query: 259 GSEPPTI----WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 + P +G +P + SN + LRL F D + RGF+ Y Sbjct: 675 DGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY 722 Score = 174 bits (442), Expect = 1e-42 Identities = 103/318 (32%), Positives = 155/318 (48%), Gaps = 44/318 (13%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGGT++G +G I SP FP Y N A+CTW I+AE + I ++F F +EE+YDYL + Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGS 300 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYE------------- 131 P PT + L+G ++PPP+ S K+ L +D GF Y+ Sbjct: 301 EP-PTIW---LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFK 356 Query: 132 -------------------ELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDG 172 + S+ C +PG P G G+ F +G +++SC Y+L G Sbjct: 357 LFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQG 416 Query: 173 HPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIV 232 +TC + A+W P+C+ + CG ++G SG +SP+FP +Y +NA C W I Sbjct: 417 AKSITCQRIAEVFAAWSDHRPVCKVK-TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVIT 475 Query: 233 A-EPGDTISLIFTDFQMEEKYDYLEI----EGSEPPTIW--LSGMNIPPPIISNKNWLRL 285 A I + F +F +E YD L I E +P T+ L+G +P I+S + + L Sbjct: 476 AVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWL 535 Query: 286 HFVTDSNHRYRGFSAPYQ 303 H TD + GF Y+ Sbjct: 536 HLQTDESVGSVGFKVNYK 553 >gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] Length = 3565 Score = 4598 bits (11927), Expect = 0.0 Identities = 2075/3301 (62%), Positives = 2592/3301 (78%), Gaps = 23/3301 (0%) Query: 370 TSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSN 429 +SK+ L H + RR+ +A+ +VKKAI+ KSRG K+ P KD S+ Sbjct: 285 SSKNWLRLHFTSDSNHRRKGFNAQ------------FQVKKAIELKSRGVKMLPSKDGSH 332 Query: 430 KFSILNEGGIKTASNLCPDPGEPENGKRIGSDFS-LGSTVQFSCDEDYVLQGAKSITCQR 488 K S+L++GG+ S++CPDPG PENG+R GSDFS +G+ VQFSC+++YVLQG+KSITCQR Sbjct: 333 KNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQR 392 Query: 489 IAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQ 548 + E AAWSDHRP+C+ +TCGSNL+GPSG TSPN+P QY+ NA CVWVIT + +KVI+ Sbjct: 393 VTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIK 452 Query: 549 INFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVG 608 + FEEF+LE GYDTLT+GD G+VGD R+VL VLTGS VPDLIVSMS+QMWLHLQ+D+S+G Sbjct: 453 LAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIG 512 Query: 609 SVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENN 668 S GFK Y+EIEK CGDPG P YG R G F + D L FEC FEL+GE+ I CQ+NN Sbjct: 513 SPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNN 572 Query: 669 QWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDL 728 QWS N P C+F C NFTA G +LSP+YPE YGNN+NC+W IIS+PGSRIHL FNDFD+ Sbjct: 573 QWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDV 632 Query: 729 ESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 788 E QFDFLAVKD + +LGTF+G EVPS L S+ HI+RLEFQ+DHS +GRGFNITY T Sbjct: 633 EPQFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTT 692 Query: 789 FGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 848 FG NEC DPGIPIN RRFGD F LGSS+S C++GF+KTQG+E+ITCIL DG V+WS + Sbjct: 693 FGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTV 752 Query: 849 PKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDV 908 P+C APCGGH +A SGVIL PGWPGYYKDSL+CEW+IEA+PGHSIKITF+RFQTE+NYD Sbjct: 753 PRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDT 812 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 968 LEV DGP SPL+G Y+GTQ PQFL S+ NF+YLLFTTDNSRS+ GF IHYESVT+ + Sbjct: 813 LEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESD 872 Query: 969 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 1028 SCLDPGIPV+G R+G DF I STV+FSCD GY LS +EPL+CE+NH W+H LP+CDALCG Sbjct: 873 SCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCG 932 Query: 1029 GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGS 1088 G ++G SGT+LSPG+P+FYPNSLNCTWT++V+HGKGVQ FHTFHLE HDYLLITE+GS Sbjct: 933 GYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGS 992 Query: 1089 FTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIP 1148 F++P+ARLTGS LP TI AGL+GNF AQLRFISDFSISYEGFNITFSEY+LEPC+DPG+P Sbjct: 993 FSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPGVP 1052 Query: 1149 QYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNN 1208 + RIGF+FG+GD+LTFSC GYRLEG +++ CLGGGRRVWSAPLPRCVAECGAS N Sbjct: 1053 AFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVKGN 1112 Query: 1209 EGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLG 1268 EG LLSPN+P NY+NNHECIY I+ +AGKGI++ R+F L +GD LK+YDGKD ++ LG Sbjct: 1113 EGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLKVYDGKDSSSRPLG 1172 Query: 1269 AFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISD 1328 FT + GL L+STSN LWLEFN++ TD+GFQL YTSF+L CEDPGIP +GY+I D Sbjct: 1173 TFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDPGIPNYGYRIRD 1232 Query: 1329 QGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILS 1388 +GHF + ++Y CNPGY +HGS+ L C++G+RR WD PLPSCIAECGG+ +SGRILS Sbjct: 1233 EGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQIHAATSGRILS 1292 Query: 1389 PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGS 1448 PGYP PYDNNL C W+IE DPG +SL F+ FDTE +HDIL+VWDGP ++D+LLKE SGS Sbjct: 1293 PGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGS 1352 Query: 1449 LIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGD 1508 +PE IHST N +T+QFD+DF+ISKSGF+IQFS+S+A C DPG+P NGTR GD RE GD Sbjct: 1353 ALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMPQNGTRYGDSREAGD 1412 Query: 1509 TVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPY 1568 TV FQCDPGY+LQG+ +ITC+Q+ NR+FWQP PP CIA CGGNLTG +G ILSPN+P PY Sbjct: 1413 TVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPY 1472 Query: 1569 PHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIE 1628 P ++CDW + VN D+VI+L F SF++EP+YDFL+IY+G DSNSPLIGS+Q S+ PERIE Sbjct: 1473 PPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIE 1532 Query: 1629 SSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCD 1688 SS N++ LAFRSD SV +GF +E+K K RE+CFDPGNIMNGTR+G D+KLGST+TY CD Sbjct: 1533 SSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNGTRVGTDFKLGSTITYQCD 1592 Query: 1689 AGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNC 1748 +GY + S++TC++G DG+P W++ LPSC+APCG + TGSEG VLSPNYP NY+ G C Sbjct: 1593 SGYKILDPSSITCVIGADGKPSWDQVLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQIC 1652 Query: 1749 VYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI 1808 +YSI VPKEFVVFGQF +FQT+L+D+ E++DG Q+ LLSSLSGSHSGE+LPL++ NQI Sbjct: 1653 LYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQI 1712 Query: 1809 TIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGY 1868 +RF++ +A+GFHFVYQAVPRTS TQCSSVPEPR+GRRIG+EF+ GS V F+CNPGY Sbjct: 1713 LLRFSAKSGASARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGY 1772 Query: 1869 ILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWK 1928 +L GS A+ C++VPN+LAQWND++P+C+VPC G T+R+GTILSPGYPEPY NNLNC+WK Sbjct: 1773 LLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWK 1832 Query: 1929 ITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLN 1988 I V EG+GIQ+QV+SFATE NWDSL+ +DGGD APRLGS+SGTT+P LLNSTSN LYL+ Sbjct: 1833 IIVTEGSGIQIQVISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLH 1892 Query: 1989 FQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS 2048 FQSDISV+AAGFHLEY +GL +C EP PS+ IKIGDRYMV DV+SFQC+ GY+LQG S Sbjct: 1893 FQSDISVAAAGFHLEYKTVGLAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRS 1952 Query: 2049 HITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFG 2108 HI+CMPG VRRWNYP P+C+A CGG +S GVILSPGFPG+YP++LDCTW I+LPIG+G Sbjct: 1953 HISCMPGTVRRWNYPSPLCIATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYG 2012 Query: 2109 VHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQN 2168 H+QF+NFSTE HD+LE+++G TS +IG+ SG +P++L STTHET ++F+SD+SQN Sbjct: 2013 AHIQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQN 2072 Query: 2169 KQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGV 2228 +QGF + YQAY+LQ+CPDP PF+NG++I +D++VGQ++SFEC+PGY LIG+ LTC HG+ Sbjct: 2073 RQGFKLAYQAYELQNCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGI 2132 Query: 2229 SRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVL 2288 +RNWN+P PRC+A CG N+T+ NGTIYSPG+PDEYP +DC WL+ VPPG+G+YINFT+L Sbjct: 2133 NRNWNYPFPRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLL 2192 Query: 2289 QTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYH 2348 QTE + D+I VWDGPDQNSPQ+G FSGNTALE+ YS++NQ+L+KFHSDF+ GFFVL++H Sbjct: 2193 QTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFH 2252 Query: 2349 AYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGA 2408 A+QL+ CQPPP VP AE+LTEDD+FEIGD ++YQC PG+TLVG ILTC+L +LQ +G+ Sbjct: 2253 AFQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGS 2312 Query: 2409 PPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE 2468 P C+ CPANE+R S+GVILSPGYP +Y N Q C+WSI VE YNIT+FV+ FQ+EK+ Sbjct: 2313 LPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQ 2372 Query: 2469 FDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY 2528 FD L+V+DG + QSP+L+ LSG+++ N TS ++++L+WS DH +KKGF+IRY A Y Sbjct: 2373 FDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPY 2432 Query: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 CS +G I+++T G + S V + C G+R+VG S+A CR++ G + WD+ P CQ Sbjct: 2433 CSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQ 2492 Query: 2589 AISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPR 2648 A+SCGIP++P NG ++ + ++V Y C++G++L S + TAVCQ DG WSN K P Sbjct: 2493 AVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPT 2552 Query: 2649 CVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWR 2708 C V CPSI + + EH WR+V+GS EY +V+ SC PGY+ G + C NGTW+ Sbjct: 2553 CKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIG 2612 Query: 2709 NERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2768 +ERP C++ISCG L PPNGNKIGT T YG+TAIFTC+ G+ LVGS VRECL++GLWS S Sbjct: 2613 DERPSCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGS 2672 Query: 2769 ETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLP 2828 ETRCLAGHCG P+ IVNG + G+ + YRDTVVYQCNPGFRL+G+SVRIC QDH WSGQ P Sbjct: 2673 ETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTP 2732 Query: 2829 SCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC 2888 CVP++CGHPG+P +G T+G+ FN NDVV F+CN GYL+QG ++AQC++N QWS P P C Sbjct: 2733 VCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTC 2792 Query: 2889 KVVNCSDPGIPANSKRESKIEH-GNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPL 2947 +VVNCSDPG N+ R + +F YG + Y C G++L GSS L C NG WD+ L Sbjct: 2793 RVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSL 2852 Query: 2948 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPH 3007 P+C+ I CGHPGVP NAVL+GE +T+G+ VHYSC G SL+G +R CQ + HWSG+ PH Sbjct: 2853 PKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPH 2912 Query: 3008 CSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQP 3067 C+G+ G CGDPGTP HGSR +F+TKS +R++C+ G+ L GS ERTCL NGSW+G QP Sbjct: 2913 CTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQP 2972 Query: 3068 ECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPN 3127 C+AV CGNPGT NG + DG FSSSVIY+C EGY SG R CTANGTW+GT P+ Sbjct: 2973 VCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPD 3032 Query: 3128 CTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT 3187 CTIISCGDPG ANG+++G D+ + VSY C PGY ME S CT +G W+ P Sbjct: 3033 CTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPV 3092 Query: 3188 CRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3247 C+AV CP PP + NG +EG++F WG SISY C GY+LS A+L+C G G W GE+PQCL Sbjct: 3093 CKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCL 3152 Query: 3248 PKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEP 3307 P FCGDPGIPA+G+ GKSF Y+SEV F C PFILVGSS R+CQADGTWSG P CI+P Sbjct: 3153 PVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDP 3212 Query: 3308 TQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECI 3367 +C +PG P G QN++ G++VGS V F C+KG+ +QGSTTRTCL +LTWSGIQ ECI Sbjct: 3213 AHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECI 3272 Query: 3368 PHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3427 PH+C+QPETPAHA+V +DLP+ GYTL+YTC PGFFLAGG+EHR C++D WTGK P+C+ Sbjct: 3273 PHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCK 3332 Query: 3428 AGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTSFNASTGR 3487 + K R T + K VP DVF N +WKG Y + G++QP TLTV FNA++ + Sbjct: 3333 S------KGVREVNETVT-KTPVPSDVFFVNSLWKGYYEYLGKRQPATLTVDWFNATSSK 3385 Query: 3488 VNATLSN-SNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFVSAEPD 3546 VNAT S S +EL L+G+YK +EA L+L+ + IK A V K + +NW +DG+VS+ + Sbjct: 3386 VNATFSEASPVELKLTGIYKKEEAHLLLKAFQIKGQADIFVSKFENDNWGLDGYVSSGLE 3445 Query: 3547 GATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAG 3606 + FQG I GKD+G+F L+R ++ +SS+ HGT+S SVA AILVPFFALI +G Sbjct: 3446 RGGFTFQGDIHGKDFGKFKLERQD-PLNPDQDSSSHYHGTSSGSVAAAILVPFFALILSG 3504 Query: 3607 FGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNLNTVCTM 3666 F FYLYK RT PK QY G + HEN+NGQA+FENPMYDTN K E KAVRFD LNTVCT+ Sbjct: 3505 FAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAVRFDTTLNTVCTV 3564 Query: 3667 V 3667 V Sbjct: 3565 V 3565 Score = 1716 bits (4443), Expect = 0.0 Identities = 1058/3156 (33%), Positives = 1548/3156 (49%), Gaps = 228/3156 (7%) Query: 443 SNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502 S+ C +PGE G G+ F++G +++SC Y+L+G +TC A+W P Sbjct: 142 SHTCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPF 201 Query: 503 CKVK-TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561 C+ + CG L+G S + +SP+FP +Y++NA C W I A I + F +F LE GYD Sbjct: 202 CRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILA-EPGDTIALVFTDFQLEEGYD 260 Query: 562 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY---KE 618 L E+ LTG +P ++S + + LH +D + GF + K Sbjct: 261 FL------EISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKA 314 Query: 619 IEKES-----------------------------CGDPGTPLYGIREGDGFSNRDV-LRF 648 IE +S C DPG P G R G FS ++F Sbjct: 315 IELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQF 374 Query: 649 ECQFGFELIGEKSIVCQENNQ----WSANIPIC-IFPCLSNFTAPMGTVLSPDYPEGYGN 703 C+ + L G KSI CQ + WS + PIC C SN P G + SP+YP Y + Sbjct: 375 SCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYED 434 Query: 704 NLNCIWTI-ISDPGSRIHLSFNDFDLESQFDFLAVKD----GDSPESPILGTFTGAEVPS 758 N +C+W I +DP I L+F +F+LE +D L V D GD+ +L TG+ VP Sbjct: 435 NAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDT--RSVLYVLTGSSVPD 492 Query: 759 HLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISV 818 + S S+ + L Q+D S+ GF Y C DPGIP +R G +F G +++ Sbjct: 493 LIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTF 552 Query: 819 ICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDS 878 C F + G ITC WSG P C C +F+A SG+ILSP +P Y ++ Sbjct: 553 ECPAAF-ELVGERVITC---QQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNN 608 Query: 879 LNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSS 938 +NC W+I +EPG I + F F E +D L V D +LG+++G +VP L SS Sbjct: 609 MNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLASSG 668 Query: 939 NFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDS 998 + + L F +D+S + GF I Y T C DPGIP++GRR+G F +GS+VSF CD Sbjct: 669 HIVRLEFQSDHSTTGRGFNITY--TTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDD 726 Query: 999 GY-RLSHEEPLLC---EKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCT 1054 G+ + E + C + N WS +P C+A CGG + SG IL PG+P +Y +SL+C Sbjct: 727 GFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCE 786 Query: 1055 WTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNF 1113 W ++ G ++ F F E ++D L + + + + PL G+ P + + GNF Sbjct: 787 WIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLIS--TGNF 844 Query: 1114 RAQLRFISDFSISYEGFNITFSEYNLE--PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSG 1171 L F +D S S GF I + LE C DPGIP G R G +FGI T+TFSC G Sbjct: 845 -MYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPG 903 Query: 1172 YRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSI 1231 Y L ++C W+ LP C A CG G +LSP +P Y N+ C ++I Sbjct: 904 YTLSDDEPLVC--ERNHQWNHALPSCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTI 961 Query: 1232 QVQAGKGINISARTFHL-AQGDVLKIYDG---KDKTTHLLGAFTGASMRGLTLSSTSNQL 1287 +V GKG+ + TFHL + D L I + + L G+ +++ + + Q Sbjct: 962 EVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQ- 1020 Query: 1288 WLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHF-AGSTIIYGCNPGYT 1346 L F SD + EGF + ++ ++L C+DPG+P F +I HF G ++ + C GY Sbjct: 1021 -LRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIG--FHFGVGDSLTFSCFLGYR 1077 Query: 1347 LHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIE 1406 L G++ L C+ G RR W PLP C+AECG KG + G +LSP +P YDNN C++ IE Sbjct: 1078 LEGATKLTCLGGGRRVWSAPLPRCVAECGASVKG-NEGTLLSPNFPSNYDNNHECIYKIE 1136 Query: 1407 VDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEIS-GSLIPEGIHSTLNIVTIQF 1465 + G + L+ +F D L+V+DG + L + L+ ++ST N + ++F Sbjct: 1137 TEAGKGIHLRTRSFQL-FEGDTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEF 1195 Query: 1466 DTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVV-FQCDPGYELQGEE 1524 +T+ + GF + ++S C DPG+P G R D DTVV + C+PGY + G Sbjct: 1196 NTNGSDTDQGFQLTYTSFDLVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSN 1255 Query: 1525 RITCIQVENRYFWQPSPPVCIAPCGGNL-TGSSGFILSPNFPHPYPHSRDCDWTITVNAD 1583 +TC+ + R W P CIA CGG + +SG ILSP +P PY ++ C W I + Sbjct: 1256 TLTCLSGDRR-VWDKPLPSCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPG 1314 Query: 1584 YVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS 1643 ISL FI F E +D L ++DGP + L+ + S LPE I S+ N++ L F SD Sbjct: 1315 KTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFF 1374 Query: 1644 VSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIM 1703 +S +GF +++ + +C DPG NGTR G + G TVT+ CD GY LQG + +TC+ Sbjct: 1375 ISKSGFSIQFSTSIAATCNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQ 1434 Query: 1704 GDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQ 1763 ++ R W P+C A CG TG G +LSPNYP+ Y G C + + V +FV+ Sbjct: 1435 LNN-RFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALI 1493 Query: 1764 FVFFQTS-LHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKG 1822 F F +D + +Y+G S L+ S GS + E + SSGN + + F S + G Sbjct: 1494 FKSFNMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIE-SSGNSLFLAFRSDASVGLSG 1552 Query: 1823 FHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVP 1882 F ++ PR + C G R+G +F +GS++ + C+ GY + +I C Sbjct: 1553 FAIEFKEKPREA---CFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGA 1609 Query: 1883 NSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV 1942 + W+ LP+C PCGG T +G +LSP YP Y C++ ITVP+ + Q Sbjct: 1610 DGKPSWDQVLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFA 1669 Query: 1943 SFATEHNWDSLDFYDGGDNNAPRL----GSYSGTTIPHLLNSTSNNLYLNFQSDISVSAA 1998 F T N D + +DG A L GS+SG T+P +TSN + L F + SA Sbjct: 1670 YFQTALN-DLAELFDGTHAQARLLSSLSGSHSGETLP---LATSNQILLRFSAKSGASAR 1725 Query: 1999 GFHLEYTAIGLDS---CPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITC--M 2053 GFH Y A+ S C P G +IG + G +V F+C+ GY LQG + + C + Sbjct: 1726 GFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSV 1785 Query: 2054 PGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQF 2113 P + +WN IP C+ C G + G ILSPG+P Y ++L+C W I + G G+ +Q Sbjct: 1786 PNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQV 1845 Query: 2114 VNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFH 2173 ++F+TE D LE+ G T+ +G SG +P+ L ST+++ L+F SD S GFH Sbjct: 1846 ISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFH 1905 Query: 2174 IVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWN 2233 + Y+ L +C +P N IG+ + V +SF+C PGYTL G S ++C+ G R WN Sbjct: 1906 LEYKTVGLAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWN 1965 Query: 2234 HPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI 2293 +P P C A CGG ++ + G I SPG+P YPN DC W + +P G G +I F TE Sbjct: 1966 YPSPLCIATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN 2025 Query: 2294 YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQL 2352 +DF+ + +GP SP IGQFSG ++ ST+++ LI F+SD + + F L+Y AY+L Sbjct: 2026 HDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYEL 2085 Query: 2353 RVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVC 2412 + C PPP N ++ D + +G + ++C PG+ L+G+ +LTC+ G + P C Sbjct: 2086 QNCPDPPPFQNGYMINSD--YSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRC 2143 Query: 2413 QVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVL 2472 C N G I SPG+PD YP L+ C W I+V G+ + + QTE D + Sbjct: 2144 DAPCGYNV--TSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYI 2201 Query: 2473 QVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---C 2529 V+DGP+ SP L SG+ ++ S+ ++V L++ +D N F + + AF C Sbjct: 2202 AVWDGPDQNSPQLGVFSGN-TALETAYSSTNQVLLKFHSDFSNG-GFFVLNFHAFQLKKC 2259 Query: 2530 STPESPPHGYIISQTGG-QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 P + P ++++ ++ V++ C G+ LVG C+ SS ++ +P C+ Sbjct: 2260 QPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSS--QLQFEGSLPTCE 2317 Query: 2589 AISCGIPKAPT--NGGILTTDY----------------LVGTRVTYFCN----------- 2619 A C + T +G IL+ Y +T F + Sbjct: 2318 A-QCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDAL 2376 Query: 2620 ----------------DGYRLSSKELTTAVCQSDGTWSNHNKT-----------PRCVVV 2652 G T+ Q WS + T P C + Sbjct: 2377 EVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYC-SL 2435 Query: 2653 TCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL--PNGTWSWRNE 2710 T P N IL + + HY C PGY +G ++ C P G + W + Sbjct: 2436 THPLKNGGILNRTAGAVGSKVHY--------FCKPGYRMVGHSNATCRRNPLGMYQWDSL 2487 Query: 2711 RPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGS--AVRECLSSGLWSE- 2767 P CQ +SCG +P NG+ G + + S ++ C GF L S A C GLWS Sbjct: 2488 TPLCQAVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNK 2547 Query: 2768 ------SETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH 2821 C + + E ++ V G Y V+ C+PG+ L G + CQ + Sbjct: 2548 GKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANG 2607 Query: 2822 NWS--GQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR 2879 W+ + PSC +SCG P G G + F+CN GY + G +C AN Sbjct: 2608 TWNIGDERPSCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANG 2667 Query: 2880 QWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQP 2939 WS C +C P N I F+Y V Y CNPG+ L G+SV IC Sbjct: 2668 LWSGSETRCLAGHCGSPDPIVN----GHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQ 2723 Query: 2940 NGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG 2999 + +W P C+ I CGHPG P + +G ++ V+++C L G S C+ NG Sbjct: 2724 DHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNG 2783 Query: 3000 HWSGSQPHCSGDATGTCGDPG----TPGHGSRQ-ESNFRTKSTVRYACDTGYILHGSEER 3054 WS P C C DPG HG + +F ++ Y C G+ L GS Sbjct: 2784 QWSSPLPTC---RVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSAL 2840 Query: 3055 TCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQ 3114 TC+ANG W P+C A+ CG+PG AN V + T+ + V YSC L G R Sbjct: 2841 TCMANGLWDRSLPKCLAISCGHPGVPANA-VLTGELFTYGAVVHYSCRGSESLIGNDTRV 2899 Query: 3115 CTANGTWSGTLPNCTIIS---CGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSR 3171 C + WSG LP+CT + CGDPG PA+G R GDD+ + + C+ G+ +L GS Sbjct: 2900 CQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGH--QLRGSP 2957 Query: 3172 IRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN-FDWGFSISYICSPGYELSFPAV 3230 RTC +NG+WSG+ P C AV+C P +NG + ++ + S+ Y C GY+ S Sbjct: 2958 ERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMT 3017 Query: 3231 LTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFIL--VGSST 3288 C NGTW+G P C CGDPG A G + G F + VS+ CN +++ V S+T Sbjct: 3018 RHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSAT 3077 Query: 3289 RICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGS 3348 C DG W+ S P C C P ++G+ + F+ GS + + C G+ L S Sbjct: 3078 IRCTKDGRWNPSKPVC---KAVLCPQPPPVQNGTVEGS-DFRWGSSISYSCMDGYQLSHS 3133 Query: 3349 TTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGT 3408 +C W G P+C+P C P PA + G ++ + + C+ F L G+ Sbjct: 3134 AILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSF-TYKSEVFFQCKSPFILV-GS 3191 Query: 3409 EHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTP 3444 RVC++D TW+G P C + DP GTP Sbjct: 3192 SRRVCQADGTWSGIQPTCIDPAHNTCPDP----GTP 3223 Score = 1487 bits (3849), Expect = 0.0 Identities = 998/3079 (32%), Positives = 1480/3079 (48%), Gaps = 216/3079 (7%) Query: 504 KVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTL 563 K + CG +QGP+GT SP FP Y + A C W+I N+ IQ++F F LE +D L Sbjct: 28 KGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNR-IQLSFHTFALEEDFDIL 86 Query: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623 ++ DG V L+G +P IVS S + L TD +V + GFK Y+ + + Sbjct: 87 SVYDGQPQQGNLKVR--LSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHT 144 Query: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVC----QENNQWSANIPICIF 679 CG+PG L G+ G F+ D +R+ C G+ L G + C W P C Sbjct: 145 CGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRA 204 Query: 680 P--CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAV 737 C ++ SP +P Y NN +C WTI+++PG I L F DF LE +DFL + Sbjct: 205 EGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEI 264 Query: 738 KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYN---------- 787 ++P TG +PS + S+ + LRL F +D + +GFN + Sbjct: 265 SGTEAPSI----WLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSR 320 Query: 788 ----------------------TFGHNECPDPGIPINARRFGDNF-QLGSSISVICEEGF 824 + CPDPGIP N RR G +F ++G+++ CE+ + Sbjct: 321 GVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNY 380 Query: 825 IKTQGTETITC-ILMDGKVMWSGLIPKCGA-PCGGHFSAPSGVILSPGWPGYYKDSLNCE 882 + QG+++ITC + + WS P C A CG + PSGVI SP +P Y+D+ +C Sbjct: 381 V-LQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCV 439 Query: 883 WVI-EAEPGHSIKITFERFQTELNYDVLEVHDGPNL--LSPLLGSYNGTQVPQFLFSSSN 939 WVI +P IK+ FE F+ E YD L V D + +L G+ VP + S SN Sbjct: 440 WVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSN 499 Query: 940 FIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSG 999 ++L +D+S + GFK Y+ + C DPGIP +G+R G F G T++F C + Sbjct: 500 QMWLHLQSDDSIGSPGFKAVYQEIEKG--GCGDPGIPAYGKRTGSSFLHGDTLTFECPAA 557 Query: 1000 YRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDV 1059 + L E + C++N+ WS P+C C + SG ILSP YPE Y N++NC W + Sbjct: 558 FELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIIS 617 Query: 1060 THGKGVQFNFHTFHLEDHHDYLLITENG-SFTQPLARLTGSDLPPTINAGLYGNFRAQLR 1118 G + F+ F +E D+L + ++G S L +G+++P + + +L Sbjct: 618 EPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLAS---SGHIVRLE 674 Query: 1119 FISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGY-RLEGT 1177 F SD S + GFNIT++ + C DPGIP G R G F +G +++F C G+ + +G+ Sbjct: 675 FQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGS 734 Query: 1178 SEIIC-LGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAG 1236 I C L G VWS+ +PRC A CG T + G++L P +P Y+++ C + I+ + G Sbjct: 735 ESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPG 794 Query: 1237 KGINISARTFHL-AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDT 1295 I I+ F D L++ DG ++ L+G + G L ST N ++L F +D Sbjct: 795 HSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQF-LISTGNFMYLLFTTDN 853 Query: 1296 EGTDEGFQLVYTS--FELSHCEDPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSL 1352 + GF + Y S E C DPGIP G++ G F ST+ + C+PGYTL Sbjct: 854 SRSSIGFLIHYESVTLESDSCLDPGIPVNGHR--HGGDFGIRSTVTFSCDPGYTLSDDEP 911 Query: 1353 LKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNI 1412 L C + W++ LPSC A CGG +G+ SG +LSPG+P Y N+L C W IEV G Sbjct: 912 LVCERNHQ--WNHALPSCDALCGGYIQGK-SGTVLSPGFPDFYPNSLNCTWTIEVSHGKG 968 Query: 1413 VSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTL---NIVTIQFDTDF 1469 V + F F E+SHD L + + ++ + + ++GS++P I + L ++F +DF Sbjct: 969 VQMIFHTFHLESSHDYLLITEDGSFSEPVAR-LTGSVLPHTIKAGLFGNFTAQLRFISDF 1027 Query: 1470 YISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCI 1529 IS GF I FS C DPGVP R G GD++ F C GY L+G ++TC+ Sbjct: 1028 SISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCL 1087 Query: 1530 QVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLA 1589 R W P C+A CG ++ G+ G +LSPNFP Y ++ +C + I A I L Sbjct: 1088 G-GGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLR 1146 Query: 1590 FISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERI-ESSSNTMHLAFRSDGSVSYTG 1648 SF + D L +YDG DS+S +G+F ++L I S+SN + L F ++GS + G Sbjct: 1147 TRSFQLFEG-DTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQG 1205 Query: 1649 FHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYY-CDAGYVLQGYSTLTCIMGDDG 1707 F L Y + C DPG G R+ + TV Y C+ GY + G +TLTC+ GD Sbjct: 1206 FQLTYTSFDLVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGD-- 1263 Query: 1708 RPGWNRALPSCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVF 1766 R W++ LPSC A CG + + G +LSP YP Y +C + I + F+ Sbjct: 1264 RRVWDKPLPSCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIV 1323 Query: 1767 FQTSL-HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHF 1825 F T + HD+++V+DGP LL SGS E + S+ N +T++F S I+ GF Sbjct: 1324 FDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIH-STFNSLTLQFDSDFFISKSGFSI 1382 Query: 1826 VYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1885 + + + C+ P+ G R G+ G +V F C+PGY L G I C + N Sbjct: 1383 QFST---SIAATCNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRF 1439 Query: 1886 AQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFA 1945 W PTCI CGG LT G ILSP YP+PY C W++ V I + SF Sbjct: 1440 F-WQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFN 1498 Query: 1946 TEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYT 2005 E ++D L Y+G D+N+P +GSY G+ P + S+ N+L+L F+SD SV +GF +E+ Sbjct: 1499 MEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFK 1558 Query: 2006 AIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRR--WNYP 2063 ++C +P +G ++G + +G +++QCD GY + S ITC+ G + W+ Sbjct: 1559 EKPREACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQV 1618 Query: 2064 IPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHD 2123 +P C A CGG + GV+LSP +P NY + C ++I +P F V QF F T ++D Sbjct: 1619 LPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQT-ALND 1677 Query: 2124 YLEVRSGSSETSTVIGRLSGPQIPSSL-FSTTHETSLYFHSDYSQNKQGFHIVYQAY--- 2179 E+ G+ + ++ LSG +L +T+++ L F + + +GFH VYQA Sbjct: 1678 LAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRT 1737 Query: 2180 ---QLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTC--LHGVSRNWNH 2234 Q S P+PR R IG++F+ G + FEC PGY L G++AL C + WN Sbjct: 1738 SDTQCSSVPEPRYGRR---IGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWND 1794 Query: 2235 PLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY 2294 +P C C GN T GTI SPGYP+ Y N +C W + V G+GI I TE + Sbjct: 1795 TIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNW 1854 Query: 2295 DFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGF-FVLSYHAYQLR 2353 D + + DG D +P++G FSG T + STSNQ+ + F SD + + F L Y L Sbjct: 1855 DSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLA 1914 Query: 2354 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413 CQ P N+ + D + + D++ +QC PG+TL G + ++C G + + P+C Sbjct: 1915 ACQEPALPSNS--IKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCI 1972 Query: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQ 2473 C L GVILSPG+P SYPN C W IS+ GY + F TE D L+ Sbjct: 1973 ATCGGTLSTLG--GVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLE 2030 Query: 2474 VYDGPNIQSPVLISLSG-DYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYC-ST 2531 + +GP SP++ SG D +A + S HE + + +DH N++GF++ Y A+ + Sbjct: 2031 IQNGPYHTSPMIGQFSGTDLPAA--LLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNC 2088 Query: 2532 PESPP--HGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHA-WDAPVPACQ 2588 P+ PP +GY+I+ + + V + C G+ L+G C+ +G + W+ P P C Sbjct: 2089 PDPPPFQNGYMIN-SDYSVGQSVSFECYPGYILIGHPVLTCQ---HGINRNWNYPFPRCD 2144 Query: 2589 AISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPR 2648 A CG NG I + + D Y + K+ + G H Sbjct: 2145 A-PCGYNVTSQNGTIYSPGF----------PDEYPI-LKDCIWLITVPPG----HGVYIN 2188 Query: 2649 CVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL-------P 2701 ++ ++N +I + +G VFS + ++ + L Sbjct: 2189 FTLLQTEAVNDYI------AVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFS 2242 Query: 2702 NGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVREC 2759 NG + N + Q+ C P P + + G + C G+ LVG+ + C Sbjct: 2243 NGGFFVLNFHAF-QLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTC 2301 Query: 2760 -LSSGLWSESETRCLAGHCGIPELIV--NGQVIGENYGYRDTVVYQCNPGFRLIGSSVRI 2816 LSS L E C E+ +G ++ Y C+ ++ + Sbjct: 2302 KLSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNIT 2361 Query: 2817 CQQDHNWSGQLPSCVPVSCGHPG-SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC 2875 D S + + V G G SP+ SGN ++ + S N YL A Sbjct: 2362 IFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRS-NQLYLRWSTDHATS 2420 Query: 2876 QANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVL 2935 + + + P C + + G N + G+ V Y C PGY + G S Sbjct: 2421 KKGFKIRYAAPYCSLTHPLKNGGILNRTAGA--------VGSKVHYFCKPGYRMVGHSNA 2472 Query: 2936 ICQPNG----QWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTG--KRSLLG 2989 C+ N QWD P C + CG P P N +G ++T S V Y C K Sbjct: 2473 TCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQ 2532 Query: 2990 QSSRTCQLNGHWS--GSQPHCSGDATGTCGDPGTPGH-------GSRQESNFRTKSTVRY 3040 Q++ CQ +G WS G P C A + + H GS E + V Sbjct: 2533 QATAVCQEDGLWSNKGKPPTCKPVACPSI-EAQLSEHVIWRLVSGSLNEYG----AQVLL 2587 Query: 3041 ACDTGYILHGSEERTCLANGSWT--GRQPECKAVQCGNPGTTANG-KVFRIDGTTFSSSV 3097 +C GY L G C ANG+W +P C+ + CG+ NG K+ + T + ++ Sbjct: 2588 SCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTL--TVYGATA 2645 Query: 3098 IYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSY 3157 I++C GY L G VR+C ANG WSG+ C CG P NG GD + V Y Sbjct: 2646 IFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVY 2705 Query: 3158 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISY 3217 C PG+ L G+ +R C + WSG P C +TC P ++G G+ F+ +++ Sbjct: 2706 QCNPGF--RLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNF 2763 Query: 3218 ICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREG-----KSFIYQSE 3272 C+ GY L + C NG WS +P C C DPG R G +SF Y Sbjct: 2764 TCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMS 2823 Query: 3273 VSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVG 3332 + + C F L+GSS C A+G W S P C+ SC +PGVP + F G Sbjct: 2824 ILYHCKKGFYLLGSSALTCMANGLWDRSLPKCL---AISCGHPGVPANAVLTGEL-FTYG 2879 Query: 3333 SVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECI---PHSCKQPETPAHANVVGMDLPS 3389 +VV + C+ L G+ TR C D WSG P C P C P TPAH + +G D + Sbjct: 2880 AVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKT 2939 Query: 3390 HGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLS 3449 L ++C+ G L G E R C + +W+G P+CEA + +P GTP+ + Sbjct: 2940 KS-LLRFSCEMGHQLRGSPE-RTCLLNGSWSGLQPVCEA---VSCGNP----GTPTNGMI 2990 Query: 3450 VPDD--VFAQNYI---WKG 3463 V D +F+ + I W+G Sbjct: 2991 VSSDGILFSSSVIYACWEG 3009 Score = 414 bits (1065), Expect = e-115 Identities = 187/279 (67%), Positives = 227/279 (81%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGG ++G NGTIESPGFP+GYPN ANCTW+II ERNRIQ+ F +FALEE++D LS+YDG Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVYDG 91 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVP 144 P N + RL+GF LP + ST S+ +L T+DFAVSA GFK YE L S +CGNPG Sbjct: 92 QPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGNPGEI 151 Query: 145 PKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGT 204 KGVL+GTRF++GDKIRYSC+ GYIL+GH LTCI + N ASWDFP P CRAE ACGGT Sbjct: 152 LKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGT 211 Query: 205 MRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPT 264 +RG+S ISSP FP+EY NNADCTWTI+AEPGDTI+L+FTDFQ+EE YD+LEI G+E P+ Sbjct: 212 LRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEISGTEAPS 271 Query: 265 IWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 IWL+GMN+P P+IS+KNWLRLHF +DSNHR +GF+A +Q Sbjct: 272 IWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQ 310 Score = 184 bits (467), Expect = 1e-45 Identities = 112/319 (35%), Positives = 159/319 (49%), Gaps = 45/319 (14%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGGTL+G + +I SP FP Y N A+CTW I+AE + I +VF F LEE YD+L + G Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEI-SG 266 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYE------------- 131 P+ + LTG +LP PV S+K+ L TSD GF ++ Sbjct: 267 TEAPSIW---LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVK 323 Query: 132 -------------------ELQSSSCGNPGVPPKGVLYGTRFD-VGDKIRYSCVTGYILD 171 L S C +PG+P G G+ F VG +++SC Y+L Sbjct: 324 MLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQ 383 Query: 172 GHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTI 231 G +TC + A+W PICRA CG +RG SG+I+SP++P +Y +NA C W I Sbjct: 384 GSKSITCQRVTETLAAWSDHRPICRAR-TCGSNLRGPSGVITSPNYPVQYEDNAHCVWVI 442 Query: 232 -VAEPGDTISLIFTDFQMEEKYDYLEI-----EGSEPPTIW-LSGMNIPPPIISNKNWLR 284 +P I L F +F++E YD L + G ++ L+G ++P I+S N + Sbjct: 443 TTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMW 502 Query: 285 LHFVTDSNHRYRGFSAPYQ 303 LH +D + GF A YQ Sbjct: 503 LHLQSDDSIGSPGFKAVYQ 521 Score = 182 bits (461), Expect = 7e-45 Identities = 98/291 (33%), Positives = 145/291 (49%), Gaps = 8/291 (2%) Query: 17 TASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEY 76 T + C G GTI SPG+P Y N NC W II E + IQI SFA E+ + Sbjct: 1795 TIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNW 1854 Query: 77 DYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSS 136 D L ++DG +G +P + ST + L SD +V+A GF + Y+ + + Sbjct: 1855 DSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLA 1914 Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 +C P +P + G R+ V D + + C GY L G ++C+ +V W++P P+C Sbjct: 1915 ACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVR--RWNYPSPLCI 1972 Query: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE 256 A CGGT+ G+I SP FP Y NN DCTW I G + F +F E +D+LE Sbjct: 1973 A--TCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLE 2030 Query: 257 IEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 I+ + P SG ++P ++S + +HF +D + +GF YQ Sbjct: 2031 IQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQ 2081 Score = 177 bits (448), Expect = 2e-43 Identities = 100/286 (34%), Positives = 152/286 (53%), Gaps = 13/286 (4%) Query: 24 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNR-IQIVFQSFALEEEYDYLSLY 82 TCG L+G +G I SP +P Y + A+C WVI + ++ I++ F+ F LE YD L++ Sbjct: 411 TCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVG 470 Query: 83 DGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 D + LTG +P + S + L L SD ++ + GFK Y+E++ CG+ Sbjct: 471 DAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGD 530 Query: 141 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 200 PG+P G G+ F GD + + C + L G +TC N+ W P C + Sbjct: 531 PGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNN----QWSGNKPSC--VFS 584 Query: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI--E 258 C SSGII SP++P EY NN +C W I++EPG I LIF DF +E ++D+L + + Sbjct: 585 CFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDD 644 Query: 259 GSEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 G T+ SG +P + S+ + +RL F +D + RGF+ Y Sbjct: 645 GISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITY 690 Score = 169 bits (428), Expect = 5e-41 Identities = 98/287 (34%), Positives = 144/287 (50%), Gaps = 8/287 (2%) Query: 22 IYTCGGTLKGL-NGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLS 80 I CGG + +G I SPG+P Y N +CTW+I A+ I + F F E +D L Sbjct: 1275 IAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILK 1334 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 ++DG +G LP + ST + +L+ SDF +S GF + + +++C + Sbjct: 1335 VWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCND 1394 Query: 141 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 200 PG+P G YG + GD + + C GY L G ++TC+ + N W P C A A Sbjct: 1395 PGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLN-NRFFWQPDPPTCIA--A 1451 Query: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI--- 257 CGG + G +G+I SP++P Y +C W + P I+LIF F ME YD+L I Sbjct: 1452 CGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEG 1511 Query: 258 EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 E S P I G P I S+ N L L F +D++ GF+ ++ Sbjct: 1512 EDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFK 1558 Score = 167 bits (424), Expect = 1e-40 Identities = 91/287 (31%), Positives = 140/287 (48%), Gaps = 8/287 (2%) Query: 22 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 +++C +G I SP +P Y N NC W+II+E +RI ++F F +E ++D+L++ Sbjct: 582 VFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAV 641 Query: 82 YDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNP 141 D +G +P + S+ + L SD + + GF + Y + C +P Sbjct: 642 KDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDP 701 Query: 142 GVPPKGVLYGTRFDVGDKIRYSCVTGYI-LDGHPQLTCIANSVNTASWDFPVPICRAEDA 200 G+P G +G RF +G + + C G++ G +TCI N W VP C A Sbjct: 702 GIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVV-WSSTVPRCEA--P 758 Query: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIE-- 258 CGG + SSG+I P +P Y ++ C W I A+PG +I + F FQ E YD LE+ Sbjct: 759 CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDG 818 Query: 259 --GSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 S P G P +IS N++ L F TD++ GF Y+ Sbjct: 819 PASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYE 865 Score = 166 bits (421), Expect = 3e-40 Identities = 101/288 (35%), Positives = 143/288 (49%), Gaps = 18/288 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYD- 83 CGG ++G +GT+ SPGFP YPN NCTW I +Q++F +F LE +DYL + + Sbjct: 931 CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITED 990 Query: 84 -GHPHPTNFRTRLTGFHLPPPVTS---TKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 P RLTG LP + + LR SDF++S GF + + E C Sbjct: 991 GSFSEPV---ARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCD 1047 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 +PGVP G F VGD + +SC GY L+G +LTC+ W P+P C AE Sbjct: 1048 DPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRV--WSAPLPRCVAE- 1104 Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI-- 257 CG +++G+ G + SP+FP+ Y NN +C + I E G I L FQ+ E D L++ Sbjct: 1105 -CGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEG-DTLKVYD 1162 Query: 258 ---EGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 S P + + + S N L L F T+ + +GF Y Sbjct: 1163 GKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTY 1210 Score = 159 bits (403), Expect = 4e-38 Identities = 97/286 (33%), Positives = 143/286 (50%), Gaps = 14/286 (4%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGG L +G I PG+P Y + +C W+I A+ + I+I F F E YD L + DG Sbjct: 759 CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDG 818 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEE--LQSSSCGNPG 142 + G P + ST + L T+D + S+ GF ++YE L+S SC +PG Sbjct: 819 PASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPG 878 Query: 143 VPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACG 202 +P G +G F + + +SC GY L L C N W+ +P C A CG Sbjct: 879 IPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNH----QWNHALPSCDA--LCG 932 Query: 203 GTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI--EGS 260 G ++G SG + SP FP+ Y N+ +CTWTI G + +IF F +E +DYL I +GS Sbjct: 933 GYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGS 992 Query: 261 -EPPTIWLSGMNIPPPI---ISNKNWLRLHFVTDSNHRYRGFSAPY 302 P L+G +P I + +L F++D + Y GF+ + Sbjct: 993 FSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITF 1038 Score = 159 bits (403), Expect = 4e-38 Identities = 93/273 (34%), Positives = 134/273 (49%), Gaps = 8/273 (2%) Query: 22 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 I TCGGTL L G I SPGFP YPN +CTW I I F +F+ E +D+L + Sbjct: 1972 IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEI 2031 Query: 82 YDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNP 141 +G H + + +G LP + ST + SD + + GFK+ Y+ + +C +P Sbjct: 2032 QNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDP 2091 Query: 142 GVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDAC 201 G + + + VG + + C GYIL GHP LTC + +N +W++P P C A C Sbjct: 2092 PPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTC-QHGIN-RNWNYPFPRCDA--PC 2147 Query: 202 GGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI---- 257 G + +G I SP FP+EY DC W I PG + + FT Q E DY+ + Sbjct: 2148 GYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWDGP 2207 Query: 258 EGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTD 290 + + P SG S+ N + L F +D Sbjct: 2208 DQNSPQLGVFSGNTALETAYSSTNQVLLKFHSD 2240 Score = 138 bits (348), Expect = 9e-32 Identities = 105/296 (35%), Positives = 138/296 (46%), Gaps = 20/296 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CG ++KG GT+ SP FP Y N C + I E I + +SF L E D L +YDG Sbjct: 1105 CGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEG-DTLKVYDG 1163 Query: 85 -----HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 P T + L G L ST + L ++ + + GF++ Y C Sbjct: 1164 KDSSSRPLGTFTKNELLGLIL----NSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCE 1219 Query: 140 NPGVPPKGVLYGTRFDVGDKI-RYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE 198 +PG+P G D + YSC GY + G LTC+ S + WD P+P C AE Sbjct: 1220 DPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCL--SGDRRVWDKPLPSCIAE 1277 Query: 199 DACGGTMR-GSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI 257 CGG + +SG I SP +P Y NN CTW I A+PG TISL F F E +D L++ Sbjct: 1278 --CGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKV 1335 Query: 258 -EGSEPPTIWL---SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309 +G I L SG +P I S N L L F +D GFS + S T Sbjct: 1336 WDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAAT 1391 Score = 137 bits (345), Expect = 2e-31 Identities = 86/289 (29%), Positives = 129/289 (44%), Gaps = 12/289 (4%) Query: 22 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 I CGG L G G I SP +P YP G C W + I ++F+SF +E YD+L + Sbjct: 1449 IAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHI 1508 Query: 82 YDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNP 141 Y+G + G P + S+ + L SD +V GF + ++E +C +P Sbjct: 1509 YEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDP 1568 Query: 142 GVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDAC 201 G G GT F +G I Y C +GY + +TC+ + SWD +P C A C Sbjct: 1569 GNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNA--PC 1626 Query: 202 GGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQ-----MEEKYDYLE 256 GG GS G++ SP++P+ Y C ++I + F FQ + E +D Sbjct: 1627 GGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTH 1686 Query: 257 IEGSEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 + ++ SG +P ++ N + L F S RGF YQ Sbjct: 1687 AQARLLSSLSGSHSGETLP---LATSNQILLRFSAKSGASARGFHFVYQ 1732 Score = 132 bits (333), Expect = 5e-30 Identities = 98/318 (30%), Positives = 143/318 (44%), Gaps = 25/318 (7%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CG + NGTI SPGFP YP +C W+I + + I F E DY++++DG Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWDG 2206 Query: 85 HPHPTNFRTRLTGFH----LPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 P +L F L +ST V L+ SDF+ F + + Q C Sbjct: 2207 ---PDQNSPQLGVFSGNTALETAYSSTNQVL-LKFHSDFSNGGF-FVLNFHAFQLKKCQP 2261 Query: 141 PGVPPKGVLY--GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE 198 P P+ + F++GD ++Y C GY L G LTC +S ++ +P C A+ Sbjct: 2262 PPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSS--QLQFEGSLPTCEAQ 2319 Query: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 257 GSSG+I SP +P Y N+ C+W+I EP I++ FQ E+++D LE+ Sbjct: 2320 CPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVF 2379 Query: 258 ---EGSEPPTIWLSGMNIPPP-IISNKNWLRLHFVTDSNHRYRGF----SAPYQGSSTLT 309 G P + LSG + S N L L + TD +GF +APY +LT Sbjct: 2380 DGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPY---CSLT 2436 Query: 310 HTTSTGELEEHNRTTTGA 327 H G + G+ Sbjct: 2437 HPLKNGGILNRTAGAVGS 2454 Score = 125 bits (314), Expect = 8e-28 Identities = 85/289 (29%), Positives = 124/289 (42%), Gaps = 15/289 (5%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEY--DYLSLY 82 CGG G G + SP +P+ Y G C + I + +VF FA + D L+ Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEF---VVFGQFAYFQTALNDLAELF 1682 Query: 83 DGHPHPTNFRTRLTGFHLPPPVT-STKSVFSLRLTSDFAVSAHGFKVYYEELQSSS---C 138 DG + L+G H + +T + LR ++ SA GF Y+ + +S C Sbjct: 1683 DGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQC 1742 Query: 139 GNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE 198 + P G G+ F G +R+ C GY+L G L C + A W+ +P C Sbjct: 1743 SSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVV- 1801 Query: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 257 C G G I SP +P Y NN +C W I+ G I + F E+ +D LEI Sbjct: 1802 -PCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIH 1860 Query: 258 ---EGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 + + P SG +P + S N L LHF +D + GF Y+ Sbjct: 1861 DGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYK 1909 Score = 93.6 bits (231), Expect = 3e-18 Identities = 59/173 (34%), Positives = 83/173 (47%), Gaps = 4/173 (2%) Query: 31 GLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDGHPHPTN 90 G +G I SPG+P Y N C+W I E I I +F E+++D L ++DG + Sbjct: 2328 GSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSP 2387 Query: 91 FRTRLTGFHLPPP-VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVL 149 L+G H TS + LR ++D A S GFK+ Y S +P + G+L Sbjct: 2388 LLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA-PYCSLTHP-LKNGGIL 2445 Query: 150 YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACG 202 T VG K+ Y C GY + GH TC N + WD P+C+A +CG Sbjct: 2446 NRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAV-SCG 2497 Score = 53.1 bits (126), Expect = 5e-06 Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 4/60 (6%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 +CG+PG P G G+ F++ D + ++C TGY+L G + C +N W P+P CR Sbjct: 2738 TCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSN----GQWSSPLPTCR 2793 Score = 52.4 bits (124), Expect = 8e-06 Identities = 28/77 (36%), Positives = 39/77 (50%), Gaps = 5/77 (6%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 CG+PG P G G F +R+SC G+ L G P+ TC+ N SW P+C A Sbjct: 2921 CGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLN----GSWSGLQPVCEA 2976 Query: 198 EDACGGTMRGSSGIISS 214 +CG ++G+I S Sbjct: 2977 V-SCGNPGTPTNGMIVS 2992 Score = 42.0 bits (97), Expect = 0.011 Identities = 18/61 (29%), Positives = 28/61 (45%), Gaps = 2/61 (3%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 SCG+PG G+ +GT F + Y C GY+++ T W+ P+C+ Sbjct: 3037 SCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSAT--IRCTKDGRWNPSKPVCK 3094 Query: 197 A 197 A Sbjct: 3095 A 3095 Score = 40.4 bits (93), Expect = 0.033 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 10/71 (14%) Query: 137 SCGNPGVPPKGVLYGTR-----FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFP 191 +C +PG + +G + F+ G I Y C G+ L G LTC+AN + WD Sbjct: 2796 NCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGL----WDRS 2851 Query: 192 VPICRAEDACG 202 +P C A +CG Sbjct: 2852 LPKCLA-ISCG 2861 Score = 40.0 bits (92), Expect = 0.043 Identities = 24/68 (35%), Positives = 30/68 (44%), Gaps = 6/68 (8%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 SCG+PGVP VL G F G + YSC L G+ C +S W +P C Sbjct: 2859 SCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDS----HWSGALPHCT 2914 Query: 197 AEDA--CG 202 + CG Sbjct: 2915 GNNPGFCG 2922 Score = 37.7 bits (86), Expect = 0.21 Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 4/58 (6%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 CG+PG+P +G L G F ++ + C + +IL G + C A+ +W P C Sbjct: 3156 CGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQAD----GTWSGIQPTC 3209 Score = 37.0 bits (84), Expect = 0.36 Identities = 16/47 (34%), Positives = 27/47 (57%), Gaps = 1/47 (2%) Query: 136 SSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIAN 181 ++C +PG P G+ +R ++VG + + C GY + G TC+AN Sbjct: 3215 NTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLAN 3261 Score = 36.2 bits (82), Expect = 0.61 Identities = 27/81 (33%), Positives = 33/81 (40%), Gaps = 5/81 (6%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 SCG+ PP G GT G ++C TGY L G C+AN + W C Sbjct: 2622 SCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGL----WSGSETRCL 2677 Query: 197 AEDACGGTMRGSSGIISSPSF 217 A CG +G IS F Sbjct: 2678 A-GHCGSPDPIVNGHISGDGF 2697 Score = 35.8 bits (81), Expect = 0.80 Identities = 25/80 (31%), Positives = 32/80 (40%), Gaps = 5/80 (6%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 C P G + G+ F G I YSC+ GY L L+C V W +P C Sbjct: 3098 CPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGV----WKGEIPQC-L 3152 Query: 198 EDACGGTMRGSSGIISSPSF 217 CG + G +S SF Sbjct: 3153 PVFCGDPGIPAEGRLSGKSF 3172 Score = 34.3 bits (77), Expect = 2.3 Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 6/79 (7%) Query: 134 QSSSCGNPGVPPKGVLYGT-RFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPV 192 ++ SCGNPG P G++ + + Y+C GY G C AN +W Sbjct: 2975 EAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTAN----GTWTGTA 3030 Query: 193 PICRAEDACGGTMRGSSGI 211 P C +CG ++GI Sbjct: 3031 PDCTI-ISCGDPGTLANGI 3048 >gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] Length = 3487 Score = 3696 bits (9584), Expect = 0.0 Identities = 1702/2976 (57%), Positives = 2168/2976 (72%), Gaps = 82/2976 (2%) Query: 406 HRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLG 465 ++VKK I+ KSRG KL P KDNS K S+L + G+ N+CPDPG PE GKR+GSDF LG Sbjct: 303 YQVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLG 362 Query: 466 STVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFP 525 S+VQF+C+E Y LQG+K ITC +++++FAAWSDHRPVC+ + C ++L+GPSG TSPNFP Sbjct: 363 SSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFP 422 Query: 526 FQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSF 585 QYD+NA CVW+ITA+N +KVI++ FEEFDLE GYDTLT+GDGG+ GD +TVL +LTG+ Sbjct: 423 IQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTS 482 Query: 586 VPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDV 645 VPDLIVS + QMWL QTD S S+GFK +Y+EIE+ SCGDPG P YG REG F + D Sbjct: 483 VPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDT 542 Query: 646 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 705 L+FECQ FEL+G+K+I CQ+NNQWSA P C+F C NFT+P G VLSP+YPE YGN+L Sbjct: 543 LKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHL 602 Query: 706 NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSH 765 +C+W I++ P SRIHL+FND D+E QFDFL +KDG + E+P+LGTF+G ++PS +TS+ H Sbjct: 603 HCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGH 662 Query: 766 ILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFI 825 + RLEFQ DHS RGFNIT+ TF HNECPDPG+P+N +RFGD+ QLGSSIS +C+EGF+ Sbjct: 663 VARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFL 722 Query: 826 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 885 TQG+ETITC+L +G V+W+ + +C APCGGH ++PSG ILSPGWPG+YKD+L+C WVI Sbjct: 723 GTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVI 782 Query: 886 EAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLF 945 EA+PG+ IKITF+RF+TE+NYD LEV DG +PL+G Y+GTQVPQFL S+SN++YLLF Sbjct: 783 EAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLF 842 Query: 946 TTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHE 1005 +TD S S+ GF++ YE++T+ + CLDPGIPV+G+R+G+DF +G+ V+FSCDSGY LS Sbjct: 843 STDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDG 902 Query: 1006 EPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1065 EPL CE N WS LP+C+ALCGG ++G SGTILSPG+P+FYPN+LNCTW ++ +HGKGV Sbjct: 903 EPLECEPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGV 962 Query: 1066 QFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSI 1125 F FHTFHLE HDYLLITENGSFTQPL +LTGS LP I+AGLYGNF AQ+RFISDFS+ Sbjct: 963 FFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSM 1022 Query: 1126 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG 1185 SYEGFNITFSEY+LEPCE+P +P Y R G FG+GDTLTFSC GYRLEGT+ I CLGG Sbjct: 1023 SYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGG 1082 Query: 1186 GRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISART 1245 RR+WS+PLPRCVAECG S T +G LLSPN+P+NY NNHECIYSIQ Q GKGI + AR Sbjct: 1083 RRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARA 1142 Query: 1246 FHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLV 1305 F L++GDVLK+YDG + + LLG F+ + M G+TL+STS+ LWL+F +D E T +GF+L Sbjct: 1143 FELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELH 1202 Query: 1306 YTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDY 1365 ++SFEL CEDPG P+FGYK+ D+GHFAGS++ + C+PGY+L GS L C++GERR WD Sbjct: 1203 FSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDR 1262 Query: 1366 PLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS 1425 PLP+C+AECGG +GE SG++LSPGYP PY++NL C+W IE + G + L FL FDTE Sbjct: 1263 PLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEV 1322 Query: 1426 HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVA 1485 HD+LR+WDGP E+ +LLKE+SG +P+ +HST N V +QF TDF+ SK GFAIQFS S A Sbjct: 1323 HDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTA 1382 Query: 1486 TACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1545 T+C DPG+P NG+R+GD E GD+ VFQCDPGY LQG I+C+++ENR+FWQPSPP CI Sbjct: 1383 TSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCI 1442 Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605 APCGG+LTG SG ILSPN+P PYP ++CDW +TV+ DYVI+L F F++EP YDFL+IY Sbjct: 1443 APCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIY 1502 Query: 1606 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPG 1665 DG DS SPLIGSF S+LP RIESSSN++ LAFRSD SVS GF ++Y RESCFDPG Sbjct: 1503 DGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPG 1562 Query: 1666 NIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSR 1725 +I NGTR+G D KLGS+VTYYC GY ++G STL+CI+G DG+P WN P C APCG + Sbjct: 1563 SIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQ 1622 Query: 1726 STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQS 1785 GS+G VLSPNYP+NY+ G C+Y + VPK++VVFGQF FF T+L+DVVEV+DG +Q S Sbjct: 1623 YVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHS 1682 Query: 1786 SLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPR 1845 LLSSLSGSH+GESLPL++ NQ+ I+F++ G A+GFHFVYQAVPRTS+TQCSSVPEPR Sbjct: 1683 RLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPR 1742 Query: 1846 FGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTK 1905 +G+R+G++F+VG+ V F+CN GY L GS I C VP +LAQWN S PTC+VPCGG LT+ Sbjct: 1743 YGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTE 1802 Query: 1906 RKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPR 1965 R+GTILSPG+PEPY N+LNCVWKI VPEGAGIQ+QVVSF TE NWDSL+ +DG DN Sbjct: 1803 RRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTM 1862 Query: 1966 LGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIG 2025 LGS+SGTT+P LLNSTSN LYL+F SDISVSAAGFHLEY +GL SCPEP PS+G+K G Sbjct: 1863 LGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTG 1922 Query: 2026 DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSP 2085 +RY+V DVVSFQC+ GY+LQGH+HI+CMPG VRRWNYP P+C+AQCGG + + GVILSP Sbjct: 1923 ERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSP 1982 Query: 2086 GFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQ 2145 GFPGNYPS++DC+W I LP+GFG H+QF+NFSTE HDY+E+R+G ETS ++GR SG + Sbjct: 1983 GFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSE 2042 Query: 2146 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQ---------------------------- 2177 +PSSL ST+HET++YFHSD+SQN+ GF + YQ Sbjct: 2043 LPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSFLRGFDLSELERTNSTPP 2102 Query: 2178 --------------AYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALT 2223 AY+LQ CPDP PF NG V G + VGQ+++FEC PGY L G+ LT Sbjct: 2103 VAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLT 2162 Query: 2224 CLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYI 2283 C HG +RNW+HPLP+CE CGGNIT+ NGT+YSPG+P Y + QDC WL+ VP G+G+ + Sbjct: 2163 CQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRL 2222 Query: 2284 NFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFF 2343 N ++LQTEP DFIT+WDGP Q +P++G F+ + A ++V S+SNQ+L+KFH D T G F Sbjct: 2223 NLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIF 2282 Query: 2344 VLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERL 2403 +++ AY L C PP +PNAE++TE++EF IGDI+RY+CLPGFTLVGN ILTC+LG L Sbjct: 2283 AIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYL 2342 Query: 2404 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2463 Q +G PP+C+V CP NEL DSTGVILS YP SYP Q C+W + VE YNI++ VE+F Sbjct: 2343 QFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYF 2402 Query: 2464 QTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIR 2523 +EK++D +++DGP+ QSP+L +LSG+YS+ +TS+ + V+L+WS+DH N+KGF+IR Sbjct: 2403 LSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIR 2462 Query: 2524 YIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAP 2583 Y A YCS P +P HG+I+ QT Q + + C+ G+RLVG S A+C + GYH W Sbjct: 2463 YSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEA 2522 Query: 2584 VPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2643 +P CQA+SCG+P+AP NG + +Y VGT+ Y C++GY L + TA C G WSN Sbjct: 2523 IPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNR 2582 Query: 2644 NKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNG 2703 N P+CV VTCP ++S +EHGRWR++ + Y+++ +++ CDPGY+ G I C NG Sbjct: 2583 NVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANG 2642 Query: 2704 TWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG 2763 WS + P C+IISCGELP PPNG++IGT + YG+TAIF+C+ G+ LVGS VREC+++G Sbjct: 2643 KWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANG 2702 Query: 2764 LWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNW 2823 LWS SE RCLAGHCG PE IVNG + GENY YR +VVYQCN GFRLIG SVRICQQDH+W Sbjct: 2703 LWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHW 2762 Query: 2824 SGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSH 2883 SG+ P CV VSCGHPGSP + + SG+ + VV +SC + G + C + W+ Sbjct: 2763 SGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTG 2822 Query: 2884 PPPMC---KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN 2940 P C V C DPGIPA+ R +F GTV+ + C G+ L GSS CQ N Sbjct: 2823 SLPHCSGTSVGVCGDPGIPAHGIRLG----DSFDPGTVMRFSCEAGHVLRGSSERTCQAN 2878 Query: 2941 GQWDKPLPECIMIDCGHPGVPPNA-VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG 2999 G W PEC +I CG+PG P NA V+ + F S++ Y C G SR C +NG Sbjct: 2879 GSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNG 2938 Query: 3000 HWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYIL--HGSEERTCL 3057 W+GS P C CGDPG P +G R ++FR TV Y C GY++ H +C Sbjct: 2939 TWTGSDPEC---LVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCT 2995 Query: 3058 ANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTA 3117 + +W G +P CKA+ C P NGKV D + SSV Y+C+EGY LS P+V C Sbjct: 2996 KDRTWNGTKPVCKALMCKPPPLIPNGKVVGSD-FMWGSSVTYACLEGYQLSLPAVFTCEG 3054 Query: 3118 NGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTI 3177 NG+W+G LP C + CGDPG+P+ G R + +VS+ C P + L GS R C Sbjct: 3055 NGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHP--PLVLVGSPRRFCQS 3112 Query: 3178 NGTWSGVMPTC---RAVTCPTP--PQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLT 3232 +GTWSG P+C TC P PQ + + G ++ + C GY L T Sbjct: 3113 DGTWSGTQPSCIDPTLTTCADPGVPQFGI-QNNSQGYQVGSTVLFRCQKGYLLQGSTTRT 3171 Query: 3233 CVGNGTWSGEVPQCLPKFCGDPGIPAQGK-------REGKSFIYQSEVSFSCNFPFILVG 3285 C+ N TWSG P C+P C P P G + IY + FS + G Sbjct: 3172 CLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFS-----LKGG 3226 Query: 3286 SSTRICQADGTWSGSSPHCIE------PTQTSCENP 3315 S R C+ADG+W+G P C+E P T+ E P Sbjct: 3227 SEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPP 3262 Score = 2254 bits (5841), Expect = 0.0 Identities = 1256/3413 (36%), Positives = 1815/3413 (53%), Gaps = 249/3413 (7%) Query: 443 SNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502 S+ C +PG NG + GS F+LG V++SC+ + L+G +TC +E A W P Sbjct: 136 SHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPS 195 Query: 503 CKVK-TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561 C+ CG L+G SG +SP+FP +Y +NA C W I A I + F +F LE GYD Sbjct: 196 CRADDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILA-ELGDTIALVFIDFQLEDGYD 254 Query: 562 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY---KE 618 L + G + L TG+ +P ++S + + LH +D + GF Y K+ Sbjct: 255 FLEV-----TGTEGSSLW-FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQ 308 Query: 619 IEKES-----------------------------CGDPGTPLYGIREGDGFSNRDVLRFE 649 IE +S C DPG P G R G F ++F Sbjct: 309 IELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFT 368 Query: 650 CQFGFELIGEKSIVCQENNQ----WSANIPIC-IFPCLSNFTAPMGTVLSPDYPEGYGNN 704 C G++L G K I C + + WS + P+C C ++ P G + SP++P Y NN Sbjct: 369 CNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNN 428 Query: 705 LNCIWTIIS-DPGSRIHLSFNDFDLESQFDFLAVKDG--DSPESPILGTFTGAEVPSHLT 761 +C+W I + +P I L+F +FDLE +D L V DG D + +L TG VP + Sbjct: 429 AHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIV 488 Query: 762 SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICE 821 S +H + L FQ D S S GF +Y C DPGIP RR G F G ++ C+ Sbjct: 489 STNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQ 548 Query: 822 EGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNC 881 F + G + ITC WS P C C +F++PSGV+LSP +P Y + L+C Sbjct: 549 PAF-ELVGQKAITC---QKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHC 604 Query: 882 EWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFI 941 W+I A P I + F E +D L + DG +P+LG+++G Q+P + SS + Sbjct: 605 VWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVA 664 Query: 942 YLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYR 1001 L F TD+S GF I + + N C DPG+PV+G+R+G +GS++SF CD G+ Sbjct: 665 RLEFQTDHSTGKRGFNITFTTFRHN--ECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFL 722 Query: 1002 LSH-EEPLLC---EKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTV 1057 + E + C E + W+ + C+A CGG + PSGTILSPG+P FY ++L+C W + Sbjct: 723 GTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVI 782 Query: 1058 DVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLT-GSDLPP-TINAGLYGNFRA 1115 + G ++ F F E ++D L + + +++ PL + G+ +P I+ Y Sbjct: 783 EAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNY----L 838 Query: 1116 QLRFISDFSISYEGFNITFSEYNLEP--CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYR 1173 L F +D S S GF + + L+ C DPGIP G R G +F +G +TFSC SGY Sbjct: 839 YLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYT 898 Query: 1174 LEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQV 1233 L + C + WS LP C A CG + G +LSP +P Y NN C + I+ Sbjct: 899 LSDGEPLECEPNFQ--WSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIET 956 Query: 1234 QAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASM-----RGLTLSSTSNQLW 1288 GKG+ + TFHL G + T L TG+ + GL + T+ Sbjct: 957 SHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQ--- 1013 Query: 1289 LEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLH 1348 + F SD + EGF + ++ ++L CE+P +P + + Q G T+ + C PGY L Sbjct: 1014 VRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQ-FGVGDTLTFSCFPGYRLE 1072 Query: 1349 GSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVD 1408 G++ + C+ G RR W PLP C+AECG G + G +LSP +P Y+NN C++ I+ Sbjct: 1073 GTARITCLGGRRRLWSSPLPRCVAECGNSVTG-TQGTLLSPNFPVNYNNNHECIYSIQTQ 1131 Query: 1409 PGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGS-LIPEGIHSTLNIVTIQFDT 1467 PG + L+ AF+ D+L+V+DG + LL S S ++ ++ST + + + F T Sbjct: 1132 PGKGIQLKARAFELSEG-DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFIT 1190 Query: 1468 DFYISKSGFAIQFSSSVATACRDPGVPMNGTR-NGDGREPGDTVVFQCDPGYELQGEERI 1526 D + GF + FSS C DPG P G + + +G G +V F CDPGY L+G E + Sbjct: 1191 DAENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEEL 1250 Query: 1527 TCIQVENRYFWQPSPPVCIAPCGGNLTGS-SGFILSPNFPHPYPHSRDCDWTITVNADYV 1585 C+ E R W P C+A CGG + G SG +LSP +P PY H+ +C WTI A Sbjct: 1251 LCLSGERRT-WDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCT 1309 Query: 1586 ISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVS 1645 I L F+ F E +D L I+DGP + L+ LP+ + S+ N++ L F +D S Sbjct: 1310 IGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTS 1369 Query: 1646 YTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGD 1705 GF +++ SC DPG NG+R G ++ G + + CD GY LQG + ++C+ + Sbjct: 1370 KQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIE 1429 Query: 1706 DGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV 1765 + R W + P+C APCG TG G +LSPNYP+ Y G C + + V ++V+ F Sbjct: 1430 N-RFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFN 1488 Query: 1766 FFQTSL-HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFH 1824 F +D + +YDG S L+ S GS + SS N + + F S ++ GF Sbjct: 1489 IFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIE-SSSNSLFLAFRSDASVSNAGFV 1547 Query: 1825 FVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1884 Y PR S S+ G R+G++ +GSSV + C+ GY + G+ + C P+ Sbjct: 1548 IDYTENPRESCFDPGSIKN---GTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDG 1604 Query: 1885 LAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSF 1944 WN+ P C PCGG G +LSP YP+ Y + C++ +TVP+ + Q F Sbjct: 1605 KPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFF 1664 Query: 1945 ATEHNWDSLDFYDGGDNNAPRLGSYSGT-TIPHLLNSTSNNLYLNFQSDISVSAAGFHLE 2003 T N D ++ +DG ++ L S SG+ T L +TSN + + F + A GFH Sbjct: 1665 HTALN-DVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFV 1723 Query: 2004 YTAIGLDS---CPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMP--GPVR 2058 Y A+ S C P G ++G + VG +V F+C+ GY+LQG I C+P G + Sbjct: 1724 YQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALA 1783 Query: 2059 RWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFST 2118 +WN P C+ CGG +++ G ILSPGFP Y +SL+C W I +P G G+ +Q V+F T Sbjct: 1784 QWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVT 1843 Query: 2119 ETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 E D LEV G+ T T++G SG +P+ L ST+++ L+F+SD S + GFH+ Y+ Sbjct: 1844 EQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKT 1903 Query: 2179 YQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238 L SCP+P NG G + V +SF+C PGY L G++ ++C+ G R WN+P P Sbjct: 1904 VGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPL 1963 Query: 2239 CEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFIT 2298 C A CGG + M G I SPG+P YP+ DC W + +P G G +I F TEP +D+I Sbjct: 1964 CIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIE 2023 Query: 2299 VWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFV----LSY----- 2347 + +GP + S +G+FSG+ S+ STS++ + FHSD + + GF + L+Y Sbjct: 2024 IRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQIS 2083 Query: 2348 --------------------------------HAYQLRVCQPPPPVPNAEILTEDDEFEI 2375 AY+L+ C P P N + + + Sbjct: 2084 SFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANG--IVRGAGYNV 2141 Query: 2376 GDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYP 2435 G + ++CLPG+ L G+ +LTC+ G D P C+V C N S G + SPG+P Sbjct: 2142 GQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNIT--SSNGTVYSPGFP 2199 Query: 2436 DSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSA 2495 Y + Q C W I+V G+ + + + QTE D + ++DGP +P L + + Sbjct: 2200 SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK 2259 Query: 2496 FNITSNGHEVFLQWSADHGNNKKGFRIRYIAF---YCSTPESPPHGYIISQTGG-QLNSV 2551 + S+ ++V L++ D F I + A+ C P P+ ++++ + + Sbjct: 2260 -TVQSSSNQVLLKFHRDAATGGI-FAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDI 2317 Query: 2552 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNG-GILTT---- 2606 VR+ C GF LVG C+ +Y ++ P P C+ + C + T+ G++ + Sbjct: 2318 VRYRCLPGFTLVGNEILTCKLGTY--LQFEGPPPICE-VHCPTNELLTDSTGVILSQSYP 2374 Query: 2607 -----------------DYLVGTRVTYFCNDGY------------------RLSSKELTT 2631 DY + V YF ++ LS Sbjct: 2375 GSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAP 2434 Query: 2632 AVCQSDGT-----WSNHN-----------KTPRCVVVTCPSINSFILEHGRWRIVNGSHY 2675 + S WS+ + P C + P ++ FIL + H Sbjct: 2435 LIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAP-LHGFILGQTSTQPGGSIH- 2492 Query: 2676 EYKTKVVFSCDPGYHGLGPASIECL--PNGTWSWRNERPYCQIISCGELPTPPNGNKIGT 2733 F C+ GY +G + C P G W P CQ +SCG P NG G Sbjct: 2493 -------FGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGK 2545 Query: 2734 QTSYGSTAIFTCDLGFMLVGSA--VRECLSSGLWSESET--RCLAGHCGIPEL----IVN 2785 + + G+ A+++C G+ L A ECL +GLWS +C+ C P++ + + Sbjct: 2546 EYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTC--PDVSSISVEH 2603 Query: 2786 GQ---VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWS--GQLPSCVPVSCGHPGS 2840 G+ + Y ++ ++ C+PG+ G V CQ + WS P+C +SCG Sbjct: 2604 GRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPI 2663 Query: 2841 PIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPA 2900 P G G + FSCN GY + G +C AN WS C +C P Sbjct: 2664 PPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIV 2723 Query: 2901 NSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGV 2960 N I N++Y V Y CN G+ L G SV ICQ + W P C+++ CGHPG Sbjct: 2724 NGH----INGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGS 2779 Query: 2961 PPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPG 3020 PP++ +SG+ YT G+ V YSC GKR+L+G S+R C L+GHW+GS PHCSG + G CGDPG Sbjct: 2780 PPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPG 2839 Query: 3021 TPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTT 3080 P HG R +F + +R++C+ G++L GS ERTC ANGSW+G QPEC + CGNPGT Sbjct: 2840 IPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTP 2899 Query: 3081 ANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPA 3140 +N +V DG FSSS++Y C EGY +G R C+ NGTW+G+ P C +I+CGDPGIPA Sbjct: 2900 SNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPA 2959 Query: 3141 NGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQIS 3200 NGLR G+D+ + V+Y C PGY ME + + +CT + TW+G P C+A+ C PP I Sbjct: 2960 NGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIP 3019 Query: 3201 NGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG 3260 NG++ G++F WG S++Y C GY+LS PAV TC GNG+W+GE+PQC P FCGDPG+P++G Sbjct: 3020 NGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRG 3079 Query: 3261 KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRH 3320 +RE + F Y+S VSFSC+ P +LVGS R CQ+DGTWSG+ P CI+PT T+C +PGVP+ Sbjct: 3080 RREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQF 3139 Query: 3321 GSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHA 3380 G QNN+ G+QVGS V F C+KG+LLQGSTTRTCLP+LTWSG P+C+PH C+QPETP HA Sbjct: 3140 GIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHA 3199 Query: 3381 NVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC----EAGSKILVKD 3436 NV +DLPS GYTLIY+CQ GF L GG+EHR C++D +WTGK PIC +G I Sbjct: 3200 NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPI---- 3255 Query: 3437 PRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTSFNASTGRVNAT-LSNS 3495 A P + +P DVFA+N +WKG+Y ++G+KQP L VT F + +VNAT + +S Sbjct: 3256 -NTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVANSKVNATMIDHS 3314 Query: 3496 NMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFVSAEPDGATYVFQGF 3555 +EL L+G YK ++ L+L++Y I P + K K+++WA+DG VS+E GAT+++QG Sbjct: 3315 GVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGS 3374 Query: 3556 IQGKDYGQFGLQRLGLNMSEGSNSSNQPH-GTNSSSVAIAILVPFFALIFAGFGFYLYKQ 3614 ++G+ +GQFG QRL L + E S H +NSSSVA AILVPF ALI AGF YLYK Sbjct: 3375 VKGQGFGQFGFQRLDLRLLESDPESIGRHFASNSSSVAAAILVPFIALIIAGFVLYLYKH 3434 Query: 3615 RTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNLNTVCTMV 3667 R PK + G + HEN N +A FENPMYD N + + A + ++TVCT V Sbjct: 3435 RRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASEAEFTVSTVCTAV 3487 Score = 1551 bits (4017), Expect = 0.0 Identities = 1023/3139 (32%), Positives = 1507/3139 (48%), Gaps = 289/3139 (9%) Query: 499 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI 558 H P + C L GP+GT SP FP+ Y + A C W ITA ++ IQ+ F+ F LE Sbjct: 17 HHPRSAGQNCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHR-IQLVFQSFALEE 75 Query: 559 GYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKE 618 +D L++ DG P + LTG +P IVS ++ + L L +D +V + GF Y+ Sbjct: 76 DFDVLSVFDGPP--QPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEV 133 Query: 619 IEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ----WSANI 674 + +CG+PG GI++G F+ D +R+ C GF L G + C ++ W + Sbjct: 134 LPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPL 193 Query: 675 PICIFP--CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQF 732 P C C G + SP +P Y NN +C WTI+++ G I L F DF LE + Sbjct: 194 PSCRADDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGY 253 Query: 733 DFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYN----- 787 DFL V + FTGA +P+ + S+ + LRL F +D + RGF+ Y Sbjct: 254 DFLEVTGTEGSSL----WFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQI 309 Query: 788 ---------------------------TFGHNECPDPGIPINARRFGDNFQLGSSISVIC 820 + GHN CPDPGIP +R G +F+LGSS+ C Sbjct: 310 ELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTC 369 Query: 821 EEGFIKTQGTETITCI-LMDGKVMWSGLIPKCGAP-CGGHFSAPSGVILSPGWPGYYKDS 878 EG+ QG++ ITC+ + D WS P C A C H PSG+I SP +P Y ++ Sbjct: 370 NEGY-DLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNN 428 Query: 879 LNCEWVIEA-EPGHSIKITFERFQTELNYDVLEVHDG--PNLLSPLLGSYNGTQVPQFLF 935 +C W+I A P IK+ FE F E YD L V DG +L GT VP + Sbjct: 429 AHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIV 488 Query: 936 SSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFS 995 S+++ ++LLF TD S S+ GFK YE + SC DPGIP +GRR G F G T+ F Sbjct: 489 STNHQMWLLFQTDGSGSSLGFKASYEEIEQG--SCGDPGIPAYGRREGSRFHHGDTLKFE 546 Query: 996 CDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTW 1055 C + L ++ + C+KN+ WS P C C + PSG +LSP YPE Y N L+C W Sbjct: 547 CQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVW 606 Query: 1056 TVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP-LARLTGSDLPPTINAGLYGNFR 1114 + + F+ +E D+L+I + + P L +G+ LP +I + Sbjct: 607 LILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSS---GHV 663 Query: 1115 AQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYR- 1173 A+L F +D S GFNITF+ + C DPG+P G R G + +G +++F C G+ Sbjct: 664 ARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLG 723 Query: 1174 LEGTSEIIC-LGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQ 1232 +G+ I C L G VW++ + RC A CG T+ G +LSP +P Y++ C + I+ Sbjct: 724 TQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIE 783 Query: 1233 VQAGKGINISARTFHLAQG-DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEF 1291 Q G I I+ F D L++ DG+ + L+G + G + L STSN L+L F Sbjct: 784 AQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQF-LISTSNYLYLLF 842 Query: 1292 NSDTEGTDEGFQLVYTSFELS--HCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHG 1349 ++D +D GFQL Y + L HC DPGIP G + + + G+ + + C+ GYTL Sbjct: 843 STDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQRHGND-FYVGALVTFSCDSGYTLSD 901 Query: 1350 SSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDP 1409 L+C + W LPSC A CGG +G SSG ILSPG+P Y NNL C W+IE Sbjct: 902 GEPLECEPNFQ--WSRALPSCEALCGGFIQG-SSGTILSPGFPDFYPNNLNCTWIIETSH 958 Query: 1410 GNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLN---IVTIQFD 1466 G V F F E+ HD L + + L ++++GS +P I + L ++F Sbjct: 959 GKGVFFTFHTFHLESGHDYLLITENGSFTQPL-RQLTGSRLPAPISAGLYGNFTAQVRFI 1017 Query: 1467 TDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERI 1526 +DF +S GF I FS C +P VP R G GDT+ F C PGY L+G RI Sbjct: 1018 SDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARI 1077 Query: 1527 TCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVI 1586 TC+ R W P C+A CG ++TG+ G +LSPNFP Y ++ +C ++I I Sbjct: 1078 TCLGGRRR-LWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGI 1136 Query: 1587 SLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPE-RIESSSNTMHLAFRSDGSVS 1645 L +F + D L +YDG ++++ L+G F S++ + S+S+++ L F +D + Sbjct: 1137 QLKARAFELSEG-DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENT 1195 Query: 1646 YTGFHLEYKAKLRESCFDPGNIMNGTRLGMD-YKLGSTVTYYCDAGYVLQGYSTLTCIMG 1704 GF L + + C DPG G ++ + + GS+V++ CD GY L+G L C+ G Sbjct: 1196 SKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSG 1255 Query: 1705 DDGRPGWNRALPSCHAPCGSRSTGS-EGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQ 1763 + R W+R LP+C A CG G G VLSP YP Y NC+++I + Sbjct: 1256 E--RRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLH 1313 Query: 1764 FVFFQTS-LHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKG 1822 F+ F T +HDV+ ++DGP + LL LSG + L S+ N + ++F++ + +G Sbjct: 1314 FLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLH-STFNSVVLQFSTDFFTSKQG 1372 Query: 1823 FHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVP 1882 F + +++T C+ P+ G R G+ + G S +F C+PGY L GS I C + Sbjct: 1373 FAIQFSV---STATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIE 1429 Query: 1883 NSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV 1942 N W S PTCI PCGG LT G ILSP YPEPY C WK+TV I + Sbjct: 1430 NRFF-WQPSPPTCIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFN 1488 Query: 1943 SFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHL 2002 F E +D L YDG D+ +P +GS+ G+ +P + S+SN+L+L F+SD SVS AGF + Sbjct: 1489 IFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVI 1548 Query: 2003 EYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRR--W 2060 +YT +SC +P + +G ++G +G V++ C GY ++G S ++C+ GP + W Sbjct: 1549 DYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVW 1608 Query: 2061 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2120 N P P+C A CGG GV+LSP +P NY S C + + +P + V QF F T Sbjct: 1609 NNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHT-A 1667 Query: 2121 IHDYLEVRSGSSETSTVIGRLSGPQIPSSL-FSTTHETSLYFHSDYSQNKQGFHIVYQAY 2179 ++D +EV G S+ S ++ LSG SL +T+++ + F + +GFH VYQA Sbjct: 1668 LNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAV 1727 Query: 2180 ------QLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLH--GVSRN 2231 Q S P+PR G +G+DF+VG + FEC GY L G+ + CL G Sbjct: 1728 PRTSATQCSSVPEPR---YGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQ 1784 Query: 2232 WNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTE 2291 WN P C CGGN+T GTI SPG+P+ Y N +C W + VP G GI I TE Sbjct: 1785 WNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTE 1844 Query: 2292 PIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGF-FVLSYHAY 2350 +D + V+DG D +G FSG T + STSNQ+ + F+SD + S F L Y Sbjct: 1845 QNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904 Query: 2351 QLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2410 L C P P VP+ + T + + + D++ +QC PG+ L G+A ++C G + + PP Sbjct: 1905 GLSSC-PEPAVPSNGVKT-GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPP 1962 Query: 2411 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2470 +C C ++ GVILSPG+P +YP+ C+W I++ G+ + F TE D Sbjct: 1963 LCIAQCGGTVEEME--GVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHD 2020 Query: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530 +++ +GP S ++ SG + ++ S HE + + +DH N+ GF++ Y S Sbjct: 2021 YIEIRNGPYETSRMMGRFSGSELPS-SLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYS 2079 Query: 2531 TPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2590 Q++S + RGF L + WD P C+A Sbjct: 2080 ---------------HQISSFL-----RGFDLSELERTNSTPPVAASYVWDLD-PGCEAY 2118 Query: 2591 ---SCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTP 2647 C P+ NG + Y VG VT+ C GY+L+ + T ++ W + P Sbjct: 2119 ELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWD--HPLP 2176 Query: 2648 RCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSW 2707 +C V +I S NG+ Y PG+ +S +C+ W Sbjct: 2177 KCEVPCGGNITS----------SNGTVY----------SPGFPSPYSSSQDCV----WLI 2212 Query: 2708 RNERPYCQIISCGELPTPPNGNKI----GTQTSYGSTAIFTCDLGFMLVGSAV------- 2756 + ++ L T P+G+ I G Q + +FT + V S+ Sbjct: 2213 TVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKF 2272 Query: 2757 -RECLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN--YGYRDTVVYQCNPGFRLIGSS 2813 R+ + G+++ + + C P ++ N +V+ EN + D V Y+C PGF L+G+ Sbjct: 2273 HRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNE 2332 Query: 2814 VRICQQDH--NWSGQLPSC---------------VPVSCGHPGS---------------- 2840 + C+ + G P C V +S +PGS Sbjct: 2333 ILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPD 2392 Query: 2841 -----------------------------PIYGRTSGNGFNFNDVVTFSCNIGYLMQGPT 2871 P+ SGN ++ +VT S N YL Sbjct: 2393 YNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGN-YSAPLIVTSSSNSVYLRWSSD 2451 Query: 2872 KAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFG 2931 A + + + P C + G G + + CN GY L G Sbjct: 2452 HAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQP--------GGSIHFGCNAGYRLVG 2503 Query: 2932 SSVLICQPNGQ----WDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL 2987 S+ IC + Q W + +P C + CG P P N ++ G++YT G+ YSC+ L Sbjct: 2504 HSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHL 2563 Query: 2988 LGQSSRT--CQLNGHWSGSQ--PHCSGDATGTCGDPGTPG--HGSRQ---ESNFRTKSTV 3038 + T C G WS P C TC D + HG + E+ ++ ++ + Sbjct: 2564 QAGAEATAECLDTGLWSNRNVPPQC---VPVTCPDVSSISVEHGRWRLIFETQYQFQAQL 2620 Query: 3039 RYACDTGYILHGSEERTCLANGSWT--GRQPECKAVQCGNPGTTANGKVFRIDG-TTFSS 3095 CD GY G C ANG W+ P C+ + CG NG RI + + + Sbjct: 2621 MLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNG--HRIGTLSVYGA 2678 Query: 3096 SVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNV 3155 + I+SC GY L G VR+C ANG WSG+ C CG P NG G++Y +V Sbjct: 2679 TAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSV 2738 Query: 3156 SYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSI 3215 Y C G+ L G +R C + WSG P C V+C P + ++ G ++ G + Sbjct: 2739 VYQCNAGF--RLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVV 2796 Query: 3216 SYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPK---FCGDPGIPAQGKREGKSFIYQSE 3272 Y C L + C +G W+G +P C CGDPGIPA G R G SF + Sbjct: 2797 RYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTV 2856 Query: 3273 VSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVG 3332 + FSC +L GSS R CQA+G+WSGS P C SC NPG P + + G Sbjct: 2857 MRFSCEAGHVLRGSSERTCQANGSWSGSQPEC---GVISCGNPGTPSNARVVFSDGLVFS 2913 Query: 3333 SVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGY 3392 S + + C++G+ G +R C + TW+G PEC+ +C P PA+ +G D + Sbjct: 2914 SSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDF-RYNK 2972 Query: 3393 TLIYTCQPGFFLAGGTEHRV----CRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKL 3448 T+ Y C PG+ + HRV C D TW G P+C+A L+ P P + P+ K Sbjct: 2973 TVTYQCVPGYMM---ESHRVSVLSCTKDRTWNGTKPVCKA----LMCKPPPLI--PNGK- 3022 Query: 3449 SVPDDVFAQNYIWKGSYNF 3467 V +++W S + Sbjct: 3023 -----VVGSDFMWGSSVTY 3036 Score = 954 bits (2465), Expect = 0.0 Identities = 764/2709 (28%), Positives = 1161/2709 (42%), Gaps = 370/2709 (13%) Query: 1017 SHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED 1076 SH + C + GP+GT+ SPG+P YPN NCTWT+ +Q F +F LE+ Sbjct: 16 SHHPRSAGQNCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEE 75 Query: 1077 HHDYLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFS 1135 D L + + + L RLTG LP TI + LR ISD+++S +GF+ T+ Sbjct: 76 DFDVLSVFDGPPQPENLRTRLTGFQLPATI---VSAATTLSLRLISDYAVSAQGFHATYE 132 Query: 1136 EYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRR--VWSAP 1193 C +PG G + G F +GD + +SC+ G+ LEG + + C G W P Sbjct: 133 VLPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFP 192 Query: 1194 LPRCVAE--CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG 1251 LP C A+ CG + GI+ SP++P Y NN +C ++I + G I + F L G Sbjct: 193 LPSCRADDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG 252 Query: 1252 -DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY---T 1307 D L++ + + FTGAS+ +SS N L L F SD GF Y Sbjct: 253 YDFLEVTGTEGSSLW----FTGASLPAPVISS-KNWLRLHFTSDGNHRQRGFSAQYQVKK 307 Query: 1308 SFEL-----------------------------SHCEDPGIPQFGYKISDQGHFAGSTII 1338 EL + C DPGIP+ G ++ GS++ Sbjct: 308 QIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRL-GSSVQ 366 Query: 1339 YGCNPGYTLHGSSLLKCM--TGERRAWDYPLPSCIAE-CGGRFKGESSGRILSPGYPFPY 1395 + CN GY L GS + CM + AW P C A C +G SG I SP +P Y Sbjct: 367 FTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRG-PSGIITSPNFPIQY 425 Query: 1396 DNNLRCMWMI-EVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDM--LLKEISGSLIPE 1452 DNN C+W+I ++P ++ L F FD E +D L V DG + D +L ++G+ +P+ Sbjct: 426 DNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPD 485 Query: 1453 GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVF 1512 I ST + + + F TD S GF + +C DPG+P G R G GDT+ F Sbjct: 486 LIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKF 545 Query: 1513 QCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSR 1572 +C P +EL G++ ITC Q N+ W P C+ C N T SG +LSPN+P Y + Sbjct: 546 ECQPAFELVGQKAITC-QKNNQ--WSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHL 602 Query: 1573 DCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSN 1632 C W I + I LAF +EP +DFL I DG + +P++G+F ++LP I SS + Sbjct: 603 HCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGH 662 Query: 1633 TMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYV 1692 L F++D S GF++ + C DPG +NG R G +LGS++++ CD G++ Sbjct: 663 VARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFL 722 Query: 1693 -LQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYS 1751 QG T+TC++ +G WN A+ C APCG T GT+LSP +P Y +C + Sbjct: 723 GTQGSETITCVL-KEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWV 781 Query: 1752 IAVPKEFVVFGQFVFFQTSL-HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITI 1810 I + + F F+T + +D +EV DG T + L+ G+ + L +S+ N + + Sbjct: 782 IEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFL-ISTSNYLYL 840 Query: 1811 RFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYIL 1870 F++ + GF Y+ + S C P G+R GN+F VG+ V F C+ GY L Sbjct: 841 LFSTDKSHSDIGFQLRYETI-TLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTL 899 Query: 1871 HGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKIT 1930 + CE PN QW+ +LP+C CGG + GTILSPG+P+ Y NNLNC W I Sbjct: 900 SDGEPLECE--PN--FQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIE 955 Query: 1931 VPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQ 1990 G G+ +F E D L + G P L +G+ +P + S LY NF Sbjct: 956 TSHGKGVFFTFHTFHLESGHDYLLITENGSFTQP-LRQLTGSRLPAPI---SAGLYGNFT 1011 Query: 1991 ------SDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSL 2044 SD S+S GF++ ++ L+ C EP+ P+ I+ G ++ VGD ++F C GY L Sbjct: 1012 AQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRL 1071 Query: 2045 QGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLP 2104 +G + ITC+ G R W+ P+P C+A+CG +++ G +LSP FP NY ++ +C ++I Sbjct: 1072 EGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQ 1131 Query: 2105 IGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHS 2163 G G+ L+ F D L+V G++ ++ ++G S ++ +L ST+ L F + Sbjct: 1132 PGKGIQLKARAFELSE-GDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFIT 1190 Query: 2164 DYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGND-FTVGQTISFECFPGYTLIGNSAL 2222 D +GF + + +++L C DP + G+ + ++ G ++SF C PGY+L G+ L Sbjct: 1191 DAENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEEL 1250 Query: 2223 TCLHGVSRNWNHPLPRCEALCGGNITA-MNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI 2281 CL G R W+ PLP C A CGG + ++G + SPGYP Y + +C W + G I Sbjct: 1251 LCLSGERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTI 1310 Query: 2282 YINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS- 2340 ++F V TE ++D + +WDGP ++ + + SG + ++ST N ++++F +DF TS Sbjct: 1311 GLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSK 1370 Query: 2341 GFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTC-RL 2399 F + + C P N D +E GD +QC PG+ L G+A ++C ++ Sbjct: 1371 QGFAIQFSVSTATSCNDPGIPQNGS--RSGDSWEAGDSTVFQCDPGYALQGSAEISCVKI 1428 Query: 2400 GERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMF 2459 R +PP C + P +GVILSP YP+ YP + C W ++V Y I + Sbjct: 1429 ENRFFWQPSPPTC--IAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALV 1486 Query: 2460 VEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKG 2519 F E +D L +YDG + SP++ S G I S+ + +FL + +D + G Sbjct: 1487 FNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPG-RIESSSNSLFLAFRSDASVSNAG 1545 Query: 2520 FRIRYI---AFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYG 2576 F I Y C P S +G + + +L S V + C G+ + G S+ C G Sbjct: 1546 FVIDYTENPRESCFDPGSIKNGTRVG-SDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDG 1604 Query: 2577 YHAWDAPVPACQA-------------ISCGIPKAPTNGGI------LTTDYLVGTRVTYF 2617 W+ P P C A +S P+ T+G I + DY+V + +F Sbjct: 1605 KPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFF 1664 Query: 2618 ---------CNDGYRLSSKELTT-------------------------AVCQSDGTWSNH 2643 +DG+ S+ L++ + + G + Sbjct: 1665 HTALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVY 1724 Query: 2644 NKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL--P 2701 PR C S+ R+ GS + V F C+ GY G IECL P Sbjct: 1725 QAVPRTSATQCSSV-----PEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVP 1779 Query: 2702 NGTWSWRNERPYCQIISCG-------------ELPTP-------------PNGNKIG--- 2732 W P C ++ CG P P P G I Sbjct: 1780 GALAQWNVSAPTC-VVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQV 1838 Query: 2733 ----TQTSYGSTAIF-----TCDLGFMLVGSAVRECLSS------------------GLW 2765 T+ ++ S +F T + G+ V L+S G Sbjct: 1839 VSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFH 1898 Query: 2766 SESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD--HNW 2823 E +T L+ C P + NG GE Y D V +QC PG+ L G + C W Sbjct: 1899 LEYKTVGLSS-CPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRW 1957 Query: 2824 SGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCN------IGY------------ 2865 + P C+ CG + G GF N C+ +G+ Sbjct: 1958 NYPPPLCI-AQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTE 2016 Query: 2866 -------LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRES-----KIEHGNF 2913 + GP + R P + + + +S K+E+ + Sbjct: 2017 PNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDL 2076 Query: 2914 TYGTVVFYDCNPGYFLFGSSVLICQPNGQ---------WDKPLPEC---IMIDCGHPGVP 2961 TY + FL G + + WD P C + +C P Sbjct: 2077 TYSHQI------SSFLRGFDLSELERTNSTPPVAASYVWDLD-PGCEAYELQECPDPEPF 2129 Query: 2962 PNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQ--LNGHWSGSQPH----CSGDATGT 3015 N ++ G Y G +V + C L G TCQ N +W P C G+ T + Sbjct: 2130 ANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSS 2189 Query: 3016 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCG 3075 G +PG S S+ + T I HG L +G + + G Sbjct: 2190 NGTVYSPGFPSPYSSSQDCVWLI-----TVPIGHGVRLNLSLLQTEPSG---DFITIWDG 2241 Query: 3076 NPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGD 3135 T VF + + + S +L R G ++ + C Sbjct: 2242 PQQTAPRLGVFT---RSMAKKTVQSSSNQVLLK--FHRDAATGGIFAIAFSAYPLTKCPP 2296 Query: 3136 PGIPANG--LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTW---SGVMPTCRA 3190 P I N + +++ +G V Y C PG+T L G+ I TC + GT+ G P C Sbjct: 2297 PTILPNAEVVTENEEFNIGDIVRYRCLPGFT--LVGNEILTCKL-GTYLQFEGPPPICE- 2352 Query: 3191 VTCPTPPQI--SNGRLEGTNFDWGFSISYICS------PGYELSF--------------- 3227 V CPT + S G + ++ + CS P Y +S Sbjct: 2353 VHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFE 2412 Query: 3228 ---------------------PAVLTCVGNGT---WSGE---------VPQCLPKFCGDP 3254 P ++T N WS + + P +C P Sbjct: 2413 IFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAP-YCSLP 2471 Query: 3255 GIPAQGKREGKSFIYQ-SEVSFSCNFPFILVGSSTRIC----QADGTWSGSSPHCIEPTQ 3309 P G G++ + F CN + LVG S IC Q WS + P C Sbjct: 2472 RAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLC---QA 2528 Query: 3310 TSCENPGVPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQ--GSTTRTCLPDLTWS--GIQ 3363 SC P P++G FG + VG+ + C +G+ LQ T CL WS + Sbjct: 2529 LSCGLPEAPKNGM---VFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVP 2585 Query: 3364 PECIPHSCKQPET----PAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTW 3419 P+C+P +C + ++ L+ C PG++ G R C+++ W Sbjct: 2586 PQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIR-CQANGKW 2644 Query: 3420 T--GKVPIC 3426 + P C Sbjct: 2645 SLGDSTPTC 2653 Score = 937 bits (2423), Expect = 0.0 Identities = 762/2585 (29%), Positives = 1118/2585 (43%), Gaps = 348/2585 (13%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGG L +GTI SPG+P Y + +C WVI A+ I+I F F E YD L + DG Sbjct: 752 CGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDG 811 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYE--ELQSSSCGNPG 142 + G +P + ST + L ++D + S GF++ YE LQS C +PG Sbjct: 812 RTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPG 871 Query: 143 VPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACG 202 +P G +G F VG + +SC +GY L L C N W +P C A CG Sbjct: 872 IPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPN----FQWSRALPSCEA--LCG 925 Query: 203 GTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI--EGS 260 G ++GSSG I SP FP+ Y NN +CTW I G + F F +E +DYL I GS Sbjct: 926 GFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGS 985 Query: 261 -EPPTIWLSGMNIPPPI---ISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGE 316 P L+G +P PI + ++ F++D + Y GF+ T S + Sbjct: 986 FTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNI----------TFSEYD 1035 Query: 317 LEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLR------NSGLDPNT 370 LE A ++ ++T E ++T L +S L Sbjct: 1036 LEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCV 1095 Query: 371 SKDGLSPHPADTQSTRRRPRHAEQIERTKE-LAVVTHRVKKAIDFKSRGF--------KL 421 ++ G S TQ T P E + + + K I K+R F K+ Sbjct: 1096 AECGNS--VTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKV 1153 Query: 422 FPGKDNSNK----FSILNEGGI---KTASNL--------------------------CPD 448 + G +NS + FS G+ T+S+L C D Sbjct: 1154 YDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCED 1213 Query: 449 PGEPENGKRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKT 507 PG P+ G ++ + GS+V FSCD Y L+G++ + C ++ W P C V Sbjct: 1214 PGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLC--LSGERRTWDRPLPTC-VAE 1270 Query: 508 CGSNLQGP-SGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 566 CG ++G SG SP +P Y+ N C+W I A I ++F FD E +D L I Sbjct: 1271 CGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEA-EAGCTIGLHFLVFDTEEVHDVLRIW 1329 Query: 567 DGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGD 626 DG + +L+ L+G +P + S + + L TD GF + + SC D Sbjct: 1330 DGPV--ESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCND 1387 Query: 627 PGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVC---QENNQWSANIPICIFPCLS 683 PG P G R GD + D F+C G+ L G I C + W + P CI PC Sbjct: 1388 PGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGG 1447 Query: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSP 743 + T P G +LSP+YPE Y C W + P I L FN F+LE +DFL + DG Sbjct: 1448 DLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDS 1507 Query: 744 ESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINA 803 SP++G+F G+++P + S+S+ L L F++D S+S GF I Y C DPG N Sbjct: 1508 LSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNG 1567 Query: 804 RRFGDNFQLGSSISVICEEGFIKTQGTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAP 862 R G + +LGSS++ C G+ + +GT T++CIL DGK +W+ P C APCGG + Sbjct: 1568 TRVGSDLKLGSSVTYYCHGGY-EVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGS 1626 Query: 863 SGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDG----PNLL 918 GV+LSP +P Y C + + + + F F T LN DV+EVHDG LL Sbjct: 1627 DGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN-DVVEVHDGHSQHSRLL 1685 Query: 919 SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV-TVNTYSCLDPGIPV 977 S L GS+ G +P ++SN + + F+ GF Y++V + C P Sbjct: 1686 SSLSGSHTGESLP---LATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPR 1742 Query: 978 HGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLC----EKNHWWSHPLPTCDALCGGDVRG 1033 +G+R G DFS+G+ V F C+SGY L + C W+ PTC CGG++ Sbjct: 1743 YGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTE 1802 Query: 1034 PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFT-QP 1092 GTILSPG+PE Y NSLNC W + V G G+Q +F E + D L + + T Sbjct: 1803 RRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTM 1862 Query: 1093 LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGS 1152 L +G+ +P +N+ + + L F SD S+S GF++ + L C +P +P G Sbjct: 1863 LGSFSGTTVPALLNS---TSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGV 1919 Query: 1153 RIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGIL 1212 + G + + D ++F C GY L+G + I C+ G R W+ P P C+A+CG + EG++ Sbjct: 1920 KTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVI 1979 Query: 1213 LSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-DVLKIYDGKDKTTHLLGAFT 1271 LSP +P NY +N +C + I + G G +I F D ++I +G +T+ ++G F+ Sbjct: 1980 LSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFS 2039 Query: 1272 GASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY------------------------- 1306 G+ + +L STS++ + F+SD GF+L Y Sbjct: 2040 GSELPS-SLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSFLRGFDLSELERTN 2098 Query: 1307 -----------------TSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHG 1349 ++EL C DP P + G+ G ++ + C PGY L G Sbjct: 2099 STPPVAASYVWDLDPGCEAYELQECPDPE-PFANGIVRGAGYNVGQSVTFECLPGYQLTG 2157 Query: 1350 SSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDP 1409 +L C G R WD+PLP C CGG S+G + SPG+P PY ++ C+W+I V Sbjct: 2158 HPVLTCQHGTNRNWDHPLPKCEVPCGGNIT-SSNGTVYSPGFPSPYSSSQDCVWLITVPI 2216 Query: 1410 GNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDF 1469 G+ V L TE S D + +WDGP + L + S+ + + S+ N V ++F D Sbjct: 2217 GHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRD- 2275 Query: 1470 YISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERIT 1527 + FAI FS+ T C P + N + E GD V ++C PG+ L G E +T Sbjct: 2276 AATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILT 2335 Query: 1528 CIQVENRYFWQPSPPVCIAPCGGN--LTGSSGFILSPNFPHPYPHSRDCDWTITVNADYV 1585 C ++ ++ PP+C C N LT S+G ILS ++P YP + C W + V DY Sbjct: 2336 C-KLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYN 2394 Query: 1586 ISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDS-KLPERIESSSNTMHLAFRSDGSV 1644 ISL F E YD I+DGP SPL+ + + P + SSSN+++L + SD + Sbjct: 2395 ISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAY 2454 Query: 1645 SYTGFHLEYKAKLRESCFDPGNIMNGTRLGM-DYKLGSTVTYYCDAGYVLQGYSTLTCIM 1703 + GF + Y A C P ++G LG + G ++ + C+AGY L G+S C Sbjct: 2455 NRKGFKIRYSAPY---CSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTR 2511 Query: 1704 GDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFG 1762 G W+ A+P C A CG G V + K Y+VG +YS + Sbjct: 2512 HPQGYHLWSEAIPLCQALSCGLPEAPKNGMV----FGKEYTVGTKAMYSCS--------- 2558 Query: 1763 QFVFFQTSLHDVVEVYDG--------PTQQSSL----LSSLSGSHSGESLPLSSGNQITI 1810 + Q E D P Q + +SS+S H L + Q Sbjct: 2559 EGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQA 2618 Query: 1811 RFTSVGPITAKGFHFVYQAVPRTSST---------------QCSSVPEPRFGRRIGNEFA 1855 + I G+++ Q V R + C +P P G RIG Sbjct: 2619 QLML---ICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSV 2675 Query: 1856 VGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGY 1915 G++ +F CN GY L GS C + N L W+ S C+ G Sbjct: 2676 YGATAIFSCNSGYTLVGSRVREC--MANGL--WSGSEVRCLAG-------------HCGT 2718 Query: 1916 PEPYDN------NLNCVWKITVPEGAG---IQVQVVSFATEHNWDSLD----FYDGGDNN 1962 PEP N N + + AG I + V +H+W G Sbjct: 2719 PEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPG 2778 Query: 1963 APRLGSYSG---TTIPHLLNSTSNNLYLNFQSDISVSAAGF------HLEYTAIGLDSCP 2013 +P SG T + S L S G H T++G+ C Sbjct: 2779 SPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGV--CG 2836 Query: 2014 EPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGG 2073 +P P+ GI++GD + G V+ F C+ G+ L+G S TC W+ P +CG Sbjct: 2837 DPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQAN--GSWSGSQP----ECG- 2889 Query: 2074 AMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSE 2133 ++S G PG PS+ ++ L FS+ ++ E R G Sbjct: 2890 --------VISCGNPGT-PSNARVVFSDGLV-----------FSSSIVY---ECREGYYA 2926 Query: 2134 TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNG 2193 T G LS + ++ + L +C DP NG Sbjct: 2927 T----GLLSRHCSVNGTWTGSDPECLVI---------------------NCGDPGIPANG 2961 Query: 2194 FVIGNDFTVGQTISFECFPGYTLIGN--SALTCLHGVSRNWNHPLPRCEAL-CGGNITAM 2250 +GNDF +T++++C PGY + + S L+C R WN P C+AL C Sbjct: 2962 LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTK--DRTWNGTKPVCKALMCKPPPLIP 3019 Query: 2251 NGTIYS--------------PGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDF 2296 NG + GY P C GNG + T + Sbjct: 3020 NGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTC-------EGNGSW-------TGELPQC 3065 Query: 2297 ITVWDGPDQNSPQIG--QFSGNTALESVYSTSNQILIKF-------HSDFTTSGFFVLSY 2347 V+ G D P G + G + SV + + L+ SD T SG S Sbjct: 3066 FPVFCG-DPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSG-TQPSC 3123 Query: 2348 HAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDG 2407 L C P VP I +++G + ++C G+ L G+ TC L G Sbjct: 3124 IDPTLTTC-ADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCL--PNLTWSG 3180 Query: 2408 APPVC 2412 PP C Sbjct: 3181 TPPDC 3185 Score = 398 bits (1022), Expect = e-110 Identities = 179/279 (64%), Positives = 220/279 (78%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 C L G NGT+ESPGFPYGYPN ANCTW I AEE++RIQ+VFQSFALEE++D LS++DG Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDG 85 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVP 144 P P N RTRLTGF LP + S + SLRL SD+AVSA GF YE L S +CGNPG Sbjct: 86 PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRL 145 Query: 145 PKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGT 204 P G+ G+ F++GDK+RYSC G+ L+GH LTC A S N+A+WDFP+P CRA+DACGGT Sbjct: 146 PNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGT 205 Query: 205 MRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPT 264 +RG SGIISSP FP+EYHNNADCTWTI+AE GDTI+L+F DFQ+E+ YD+LE+ G+E + Sbjct: 206 LRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVTGTEGSS 265 Query: 265 IWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 +W +G ++P P+IS+KNWLRLHF +D NHR RGFSA YQ Sbjct: 266 LWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQ 304 Score = 193 bits (490), Expect = 3e-48 Identities = 110/313 (35%), Positives = 155/313 (49%), Gaps = 16/313 (5%) Query: 22 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 + CGG L GTI SPGFP Y N NC W I+ E IQI SF E+ +D L + Sbjct: 1793 VVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEV 1852 Query: 82 YDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNP 141 +DG + +G +P + ST + L SD +VSA GF + Y+ + SSC P Sbjct: 1853 FDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEP 1912 Query: 142 GVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDAC 201 VP GV G R+ V D + + C GY L GH ++C+ +V W++P P+C A+ C Sbjct: 1913 AVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVR--RWNYPPPLCIAQ--C 1968 Query: 202 GGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSE 261 GGT+ G+I SP FP Y +N DC+W I G + F +F E +DY+EI Sbjct: 1969 GGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGP 2028 Query: 262 PPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTST--- 314 T + SG +P ++S + ++F +D + GF YQ T +H S+ Sbjct: 2029 YETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ-DLTYSHQISSFLR 2087 Query: 315 ----GELEEHNRT 323 ELE N T Sbjct: 2088 GFDLSELERTNST 2100 Score = 184 bits (466), Expect = 2e-45 Identities = 113/318 (35%), Positives = 160/318 (50%), Gaps = 44/318 (13%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGGTL+G +G I SP FP Y N A+CTW I+AE + I +VF F LE+ YD+L + Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVTGT 261 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYE-----ELQS---- 135 F TG LP PV S+K+ L TSD GF Y+ EL+S Sbjct: 262 EGSSLWF----TGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSRGVK 317 Query: 136 -----------------------SSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDG 172 + C +PG+P +G G+ F +G ++++C GY L G Sbjct: 318 LMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQG 377 Query: 173 HPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIV 232 ++TC+ S A+W P+CRA C +RG SGII+SP+FP +Y NNA C W I Sbjct: 378 SKRITCMKVSDMFAAWSDHRPVCRAR-MCDAHLRGPSGIITSPNFPIQYDNNAHCVWIIT 436 Query: 233 A-EPGDTISLIFTDFQMEEKYDYLEI-----EGSEPPTIW-LSGMNIPPPIISNKNWLRL 285 A P I L F +F +E YD L + +G + ++ L+G ++P I+S + + L Sbjct: 437 ALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWL 496 Query: 286 HFVTDSNHRYRGFSAPYQ 303 F TD + GF A Y+ Sbjct: 497 LFQTDGSGSSLGFKASYE 514 Score = 165 bits (418), Expect = 7e-40 Identities = 98/285 (34%), Positives = 146/285 (51%), Gaps = 13/285 (4%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNR-IQIVFQSFALEEEYDYLSLYD 83 C L+G +G I SP FP Y N A+C W+I A ++ I++ F+ F LE YD L++ D Sbjct: 405 CDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGD 464 Query: 84 GHPHPTNFRTR--LTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNP 141 G LTG +P + ST L +D + S+ GFK YEE++ SCG+P Sbjct: 465 GGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDP 524 Query: 142 GVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDAC 201 G+P G G+RF GD +++ C + L G +TC N+ W P C +C Sbjct: 525 GIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNN----QWSAKKPGC--VFSC 578 Query: 202 GGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG-- 259 SG++ SP++P +Y N+ C W I+A P I L F D +E ++D+L I+ Sbjct: 579 FFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGA 638 Query: 260 -SEPPTI-WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 +E P + SG +P I S+ + RL F TD + RGF+ + Sbjct: 639 TAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF 683 Score = 157 bits (398), Expect = 1e-37 Identities = 88/289 (30%), Positives = 135/289 (46%), Gaps = 8/289 (2%) Query: 20 GFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYL 79 G +++C +G + SP +P Y N +C W+I+A +RI + F +E ++D+L Sbjct: 573 GCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFL 632 Query: 80 SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 + DG +G LP +TS+ V L +D + GF + + + + C Sbjct: 633 VIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECP 692 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYI-LDGHPQLTCIANSVNTASWDFPVPICRAE 198 +PGVP G +G +G I + C G++ G +TC+ + W+ V R E Sbjct: 693 DPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKE-GSVVWNSAV--LRCE 749 Query: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIE 258 CGG + SG I SP +P Y + C W I A+PG I + F F+ E YD LE+ Sbjct: 750 APCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVR 809 Query: 259 G----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 S P G +P +IS N+L L F TD +H GF Y+ Sbjct: 810 DGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYE 858 Score = 133 bits (335), Expect = 3e-30 Identities = 75/218 (34%), Positives = 103/218 (47%), Gaps = 3/218 (1%) Query: 22 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 I CGG L G +G I SP +P YP G C W + I +VF F LE YD+L + Sbjct: 1442 IAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHI 1501 Query: 82 YDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNP 141 YDG + G LP + S+ + L SD +VS GF + Y E SC +P Sbjct: 1502 YDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDP 1561 Query: 142 GVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDAC 201 G G G+ +G + Y C GY ++G L+CI W+ P P+C A C Sbjct: 1562 GSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTA--PC 1619 Query: 202 GGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTI 239 GG GS G++ SP++P Y + C + V P D + Sbjct: 1620 GGQYVGSDGVVLSPNYPQNYTSGQICLY-FVTVPKDYV 1656 >gi|148886654 polydom [Homo sapiens] Length = 3571 Score = 521 bits (1341), Expect = e-147 Identities = 391/1329 (29%), Positives = 559/1329 (42%), Gaps = 142/1329 (10%) Query: 2184 CPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL- 2242 C P NG G +TVG ++F C GY L+G + +TCL S WNH +P C+A+ Sbjct: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLE--SGEWNHLIPYCKAVS 1846 Query: 2243 CGGNITAMNGTIYSPGYPDEYPNFQDC--FWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300 CG NG I + C + + + N + + P+ + + Sbjct: 1847 CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC- 1905 Query: 2301 DGPDQNSPQIGQFSGNTALESV-YSTSNQILIKFHS--DFTTSGFFVLSYHAYQLRVCQP 2357 P+ + SG T L + YS ++ S + T SG + + A L C Sbjct: 1906 SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGE 1965 Query: 2358 PPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMD--------GA 2408 PP + +A I + F + + Y C G+TL G + C G+ + D Sbjct: 1966 PPAIKDAVI--TGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDE 2023 Query: 2409 PPVCQVLCPANELRL--DSTGVILSPGYPDSYPNLQMC----AWSISVEKGYNITMFVEF 2462 PP+ P RL D S GY + + +C W +G ++ + Sbjct: 2024 PPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKW--VPPEGQDMPRCIAH 2081 Query: 2463 FQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITS-NGHEVFL-------------Q 2508 F EK P++ +L S+S +A ++ S E F+ Q Sbjct: 2082 F-CEKP---------PSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQ 2131 Query: 2509 WSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSA 2568 W N I+ I C P S +GY S + ++V ++C++GF + G+ + Sbjct: 2132 W------NPSPMSIQCIPVRCGEPPSIMNGY-ASGSNYSFGAMVAYSCNKGFYIKGEKKS 2184 Query: 2569 VCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSK 2627 C + W +P+P C +SCG P NG + TT + + V Y CN GY+ S Sbjct: 2185 TCEATG----QWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYK--SV 2238 Query: 2628 ELTTAVCQSDGTWSNHNKTP-RCVVVTC----PSINSFILEHGRWRIVNGSHYEYKTKVV 2682 VCQ++ W H+++P CV + C P N F + G ++E +KV Sbjct: 2239 GSPVFVCQANRHW--HSESPLMCVPLDCGKPPPIQNGF---------MKGENFEVGSKVQ 2287 Query: 2683 FSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAI 2742 F C+ GY +G +S C +G W+ + P C C E P N + T+ Sbjct: 2288 FFCNEGYELVGDSSWTCQKSGKWN-KKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVT 2346 Query: 2743 FTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN-YGYRDTVVY 2801 F+C G +L G +V +CL S W++S C C P LI G I + + TV Y Sbjct: 2347 FSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKY 2406 Query: 2802 QCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSC 2861 C GF L G+S +CQ D WS LP CVPV C P G G + ++C Sbjct: 2407 SCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTC 2466 Query: 2862 NIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFY 2921 G+ + G T C N W P CK + C P N K + + YG V Y Sbjct: 2467 KPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILN----GKFSYTDLHYGQTVTY 2522 Query: 2922 DCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSC 2981 CN G+ L G S L C G WD P C I C P N + G Y++G+ + YSC Sbjct: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSC 2582 Query: 2982 TGKRSLLGQSSRTCQLNGHWSGSQPHCS------------GDATGTCGDPG--------- 3020 + G + +TC+ +G WS S P C GD T D G Sbjct: 2583 FPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMM 2641 Query: 3021 ----------------------TPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3058 T + SNF + V Y C+ GY L G+ C Sbjct: 2642 EVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQE 2701 Query: 3059 NGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTAN 3118 +G+W G P C +++C P NG R T+ S+V YSC G+IL+G +R C N Sbjct: 2702 DGTWNGSAPSCISIECDLPTAPENG-FLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760 Query: 3119 GTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN 3178 WSG P C ISC P NG G +Y + Y C PGY LNG+ RTC + Sbjct: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYV--LNGTERRTCQDD 2818 Query: 3179 GTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT 3238 W P C V C +PP +NG++ G + + I Y C+ G+ L C+ NG+ Sbjct: 2819 KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGS 2878 Query: 3239 WSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWS 3298 WSG P C+P C P A G EG + + EV+F C+ +IL G+ CQ+DG W Sbjct: 2879 WSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD 2938 Query: 3299 GSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLT 3358 P C +C P HG N F F G +Q+ C G+ L G+++R CL + + Sbjct: 2939 AEIPLC---KPVNCGPPEDLAHGFPNG-FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGS 2994 Query: 3359 WSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT 3418 WSG P C+P C P + V G D G C GF L G +E C +D Sbjct: 2995 WSGSSPSCLPCRCSTP-VIEYGTVNGTDFDC-GKAARIQCFKGFKLLGLSE-ITCEADGQ 3051 Query: 3419 WTGKVPICE 3427 W+ P CE Sbjct: 3052 WSSGFPHCE 3060 Score = 494 bits (1271), Expect = e-139 Identities = 335/1075 (31%), Positives = 480/1075 (44%), Gaps = 119/1075 (11%) Query: 2355 CQPPPPVPNAEILTEDDEFEIGDI----IRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2410 C PP V N + E G I +RYQC PG+ VG+ + C+ + +P Sbjct: 2204 CGEPPKVENGFL-----EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSE-SPL 2257 Query: 2411 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2470 +C V L G P N M + + + V+FF E Sbjct: 2258 MC---------------VPLDCGKPPPIQNGFMKG------ENFEVGSKVQFFCNEG--- 2293 Query: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530 L GD S++ +G +W NKK + + C Sbjct: 2294 ---------------YELVGD--SSWTCQKSG-----KW------NKKS-NPKCMPAKCP 2324 Query: 2531 TPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2590 P + ++ + ++ VV ++C G L G S C S W+ P C+ + Sbjct: 2325 EPPLLENQLVLKELTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVCKIV 2379 Query: 2591 SCGIPKAPTNGGILTTDYL-VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRC 2649 C P + G + + L G+ V Y C G+ L +T +CQ DGTWS+ P C Sbjct: 2380 LCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGN--STTLCQPDGTWSS--PLPEC 2435 Query: 2650 VVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRN 2709 V V CP + +G I++ Y + +++C PG+ +G + C NG W Sbjct: 2436 VPVECPQPEE--IPNG---IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENG--HWLG 2488 Query: 2710 ERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESE 2769 +P C+ I C + NG T YG T ++C+ GF L G + CL +G W Sbjct: 2489 GKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDA 2548 Query: 2770 TRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2829 C A HC P+ I NG V G +Y Y ++Y C PGF++ G +++ C++ WS +P+ Sbjct: 2549 PSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEES-GWSSSIPT 2607 Query: 2830 CVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2889 C+P+ CG P +F D + GY Q + HPP Sbjct: 2608 CMPIDCGLPPH----------IDFGDCTKLKDDQGYFEQEDD--MMEVPYVTPHPPYHLG 2655 Query: 2890 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPE 2949 V + N+K NF YGT+V Y CNPGY L G+ VLICQ +G W+ P Sbjct: 2656 AVAKTWE----NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPS 2711 Query: 2950 CIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCS 3009 CI I+C P P N L + + GS V YSC L G R C N WSG+ P C Sbjct: 2712 CISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCE 2771 Query: 3010 GDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC 3069 +C P +GS + SN+ ST+ Y CD GY+L+G+E RTC + +W +P C Sbjct: 2772 AI---SCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPIC 2828 Query: 3070 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129 V C +P +ANG+V R D TF + Y+C EG++L G R C ANG+WSG P+C Sbjct: 2829 IPVDCSSPPVSANGQV-RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCV 2887 Query: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3189 + C P ANG+ G DY + V++ C GY L+G+ TC +G W +P C+ Sbjct: 2888 PVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYI--LHGAPKLTCQSDGNWDAEIPLCK 2945 Query: 3190 AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPK 3249 V C P +++G G +F G I Y C PGY+L + C+ NG+WSG P CLP Sbjct: 2946 PVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPC 3005 Query: 3250 FCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQ 3309 C P I G G F C F L+G S C+ADG WS PHC Sbjct: 3006 RCSTPVI-EYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHC---EH 3061 Query: 3310 TSCEN-PGVPRHGSQNNTFGFQVGS----VVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP 3364 TSC + P +P N F + S V+ + C+ G+++QGS+ C WS P Sbjct: 3062 TSCGSLPMIP------NAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYP 3115 Query: 3365 ECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTW 3419 C P SC P + A+A G + ++ + C G+ + T+ C+ D W Sbjct: 3116 VCEPLSCGSPPSVANAVATG-EAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW 3169 Score = 458 bits (1178), Expect = e-128 Identities = 327/1164 (28%), Positives = 486/1164 (41%), Gaps = 146/1164 (12%) Query: 2346 SYHAYQLRVCQPPP------PVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL 2399 S+ ++ +C PPP P+P++ + G ++Y C+ GF L GN+ C Sbjct: 2372 SFPVCKIVLCTPPPLISFGVPIPSSAL-------HFGSTVKYSCVGGFFLRGNSTTLC-- 2422 Query: 2400 GERLQMDGA-----PPVCQVLCPANE------------LRLDSTGVILSPGYPDSYPNLQ 2442 Q DG P V CP E L + PG+ Sbjct: 2423 ----QPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTT 2478 Query: 2443 MCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQSPVLISLSGDYSSAFNI 2498 +C + G +E + ++ +F ++ G + + SA Sbjct: 2479 LCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTC 2538 Query: 2499 TSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDR 2558 G W D + A +C +P+ +G++ +++ ++C Sbjct: 2539 LETG-----DWDVDAPSCN--------AIHCDSPQPIENGFV-EGADYSYGAIIIYSCFP 2584 Query: 2559 GFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK---------------------- 2596 GF++ G + C +S W + +P C I CG+P Sbjct: 2585 GFQVAGHAMQTCEESG-----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDD 2639 Query: 2597 ----------APTNGGIL--------------TTDYLVGTRVTYFCNDGYRLSSKELTTA 2632 P + G + ++++L GT V+Y CN GY L + Sbjct: 2640 MMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVL-- 2697 Query: 2633 VCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2692 +CQ DGTW+ P C+ + C + E+G R S + V +SC PG+ Sbjct: 2698 ICQEDGTWNG--SAPSCISIECDLPTA--PENGFLRFTETS---MGSAVQYSCKPGHILA 2750 Query: 2693 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLV 2752 G CL N WS + P C+ ISC + NG+ G+ +Y ST + CD G++L Sbjct: 2751 GSDLRLCLENRKWSGAS--PRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLN 2808 Query: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGS 2812 G+ R C W E E C+ C P + NGQV G+ Y ++ + Y CN GF L G+ Sbjct: 2809 GTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGA 2868 Query: 2813 SVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2872 R+C + +WSG P CVPV C P G T G + F VTF C+ GY++ G K Sbjct: 2869 RSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPK 2928 Query: 2873 AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHG-----NFTYGTVVFYDCNPGY 2927 CQ++ W P+CK VNC P + HG +F +G + Y C PGY Sbjct: 2929 LTCQSDGNWDAEIPLCKPVNCGPP---------EDLAHGFPNGFSFIHGGHIQYQCFPGY 2979 Query: 2928 FLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL 2987 L G+S C NG W P C+ C P + V +G + G C L Sbjct: 2980 KLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTV-NGTDFDCGKAARIQCFKGFKL 3038 Query: 2988 LGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYI 3047 LG S TC+ +G WS PHC + G+ P P + S+++ ++ + Y+C +GY+ Sbjct: 3039 LGLSEITCEADGQWSSGFPHCEHTSCGSL--PMIPNAFISETSSWK-ENVITYSCRSGYV 3095 Query: 3048 LHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYIL 3107 + GS + C G W+ P C+ + CG+P + AN V + T+ S V C+EGY + Sbjct: 3096 IQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANA-VATGEAHTYESEVKLRCLEGYTM 3154 Query: 3108 -SGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTME 3166 + C +G W +C+ C P + L +GDD+ V + VS C GYT E Sbjct: 3155 DTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFE 3214 Query: 3167 LNGSRIRTCTINGTWSGVMP--TCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYE 3224 G I C ++GTW +C V+C P +G + G+ + + +I Y C PGYE Sbjct: 3215 --GVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYE 3272 Query: 3225 LSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILV 3284 L C N WSG V C C P GK + ++ V +SCN + L Sbjct: 3273 LEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLE 3332 Query: 3285 GSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHL 3344 G S C +GTWS P C C P V + + F V V C++G L Sbjct: 3333 GPSEAHCTENGTWSHPVPLC---KPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFL 3389 Query: 3345 LQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFL 3404 LQG TC PD TW+ +C SC P +A G+ +G + Y+C G+ L Sbjct: 3390 LQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHY-QYGDMITYSCYSGYML 3448 Query: 3405 AGGTEHRVCRSDNTWTGKVPICEA 3428 G VC + TWT PIC A Sbjct: 3449 EGFL-RSVCLENGTWTSP-PICRA 3470 Score = 437 bits (1123), Expect = e-121 Identities = 285/926 (30%), Positives = 402/926 (43%), Gaps = 71/926 (7%) Query: 2550 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYL 2609 S V CD GF+LVG C W P+P C+ ISCG+P NG D+ Sbjct: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQ----WTQPLPHCERISCGVPPPLENGFHSADDFY 1707 Query: 2610 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRI 2669 G+ VTY CN+GY L + C +G+W+ +P C+ V ++ S EH Sbjct: 1708 AGSTVTYQCNNGYYLLGD--SRMFCTDNGSWNG--VSPSCLDVDECAVGSDCSEHASCLN 1763 Query: 2670 VNGSH------------------------------------YEYKTKVVFSCDPGYHGLG 2693 V+GS+ Y +V FSC GY +G Sbjct: 1764 VDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMG 1823 Query: 2694 PASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVG 2753 I CL +G W+ + PYC+ +SCG+ P NG ++GS + C+ G+ L G Sbjct: 1824 VTKITCLESGEWN--HLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAG 1881 Query: 2754 SAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSS 2813 CL++ WS S C C PE I NG+ I Y T Y C+ G+ L G S Sbjct: 1882 DKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPS 1941 Query: 2814 VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKA 2873 + C W P+C V CG P + +GN F F + VT++C GY + G Sbjct: 1942 IIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTI 2001 Query: 2874 QCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS 2933 +C A+ +WS C V+C +P I ++ E+ + +G + FY C+ GY L +S Sbjct: 2002 ECLADGKWSRSDQQCLAVSCDEPPIVDHASPET----AHRLFGDIAFYYCSDGYSLADNS 2057 Query: 2934 VLICQPNGQWDKP----LPECIMIDCGHPGVPPNAVL---SGEKYTFGSTVHYSCTGKRS 2986 L+C G+W P +P CI C P ++L S K+ GS V + C Sbjct: 2058 QLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFV 2117 Query: 2987 LLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGY 3046 L + C G W+ S P CG+P + +G SN+ + V Y+C+ G+ Sbjct: 2118 LNTSAKIECMRGGQWNPS-PMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGF 2176 Query: 3047 ILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYI 3106 + G ++ TC A G W+ P C V CG P NG + G F S V Y C GY Sbjct: 2177 YIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYK 2236 Query: 3107 LSGPSVRQCTANGTWSGTLP-NCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTM 3165 G V C AN W P C + CG P NG G+++ VG V + C GY Sbjct: 2237 SVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGY-- 2294 Query: 3166 ELNGSRIRTCTINGTWSGVM-PTCRAVTCPTPPQISNGR-LEGTNFDWGFSISYICSPGY 3223 EL G TC +G W+ P C CP PP + N L+ + G +++ C G+ Sbjct: 2295 ELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGV-VTFSCKEGH 2353 Query: 3224 ELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFI-YQSEVSFSCNFPFI 3282 L P+VL C+ + W+ P C C P + + G S + + S V +SC F Sbjct: 2354 VLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFF 2413 Query: 3283 LVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKG 3342 L G+ST +CQ DGTWS P C+ C P +G + G S + CK G Sbjct: 2414 LRGNSTTLCQPDGTWSSPLPECV---PVECPQPEEIPNGI-IDVQGLAYLSTALYTCKPG 2469 Query: 3343 HLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGF 3402 L G+TT C + W G +P C C +P+ + DL +G T+ Y+C GF Sbjct: 2470 FELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDL-HYGQTVTYSCNRGF 2528 Query: 3403 FLAGGTEHRVCRSDNTWTGKVPICEA 3428 L G + C W P C A Sbjct: 2529 RLEGPSA-LTCLETGDWDVDAPSCNA 2553 Score = 379 bits (974), Expect = e-104 Identities = 333/1226 (27%), Positives = 494/1226 (40%), Gaps = 154/1226 (12%) Query: 2203 GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPD 2261 G T+ + C G+ L GNS C W+ PLP C + C NG I G Sbjct: 2401 GSTVKYSCVGGFFLRGNSTTLCQP--DGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAY 2458 Query: 2262 EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI----------G 2311 C PG + N T L E + W G I G Sbjct: 2459 LSTALYTC------KPGFELVGNTTTLCGENGH-----WLGGKPTCKAIECLKPKEILNG 2507 Query: 2312 QFS------GNTALESVYSTSNQILIKFHSDFTT--SGFFVLSYHAYQLRVCQPPPPVPN 2363 +FS G T YS + ++ S T +G + + + C P P+ N Sbjct: 2508 KFSYTDLHYGQTV---TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIEN 2564 Query: 2364 AEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL---CPANE 2420 + E ++ G II Y C PGF + G+A+ TC E + P C + P + Sbjct: 2565 GFV--EGADYSYGAIIIYSCFPGFQVAGHAMQTC---EESGWSSSIPTCMPIDCGLPPHI 2619 Query: 2421 LRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----------FD 2470 D T + GY + ++ + ++ Y++ + ++ KE + Sbjct: 2620 DFGDCTKLKDDQGYFEQEDDMMEVPY-VTPHPPYHLGAVAKTWENTKESPATHSSNFLYG 2678 Query: 2471 VLQVY------------------DGP-NIQSPVLISLSGDYSSA-------FNITSNGHE 2504 + Y DG N +P IS+ D +A F TS G Sbjct: 2679 TMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSA 2738 Query: 2505 VFLQWSADHGN------------NKK--GFRIRYIAFYCSTPESPPHGYIISQTGGQLNS 2550 V Q+S G+ N+K G R A C P +G I L S Sbjct: 2739 V--QYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYL-S 2795 Query: 2551 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLV 2610 + + CD G+ L G C+ WD P C + C P NG + +Y Sbjct: 2796 TLYYECDPGYVLNGTERRTCQDDKN----WDEDEPICIPVDCSSPPVSANGQVRGDEYTF 2851 Query: 2611 GTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIV 2670 + Y CN+G+ L + VC ++G+WS TP CV V C + L +G + Sbjct: 2852 QKEIEYTCNEGFLLEGAR--SRVCLANGSWSG--ATPDCVPVRCATPPQ--LANG---VT 2902 Query: 2671 NGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNK 2730 G Y + +V F C GY G + C +G W E P C+ ++CG +G Sbjct: 2903 EGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD--AEIPLCKPVNCGPPEDLAHGFP 2960 Query: 2731 IGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIG 2790 G +G + C G+ L G++ R CLS+G WS S CL C P +I G V G Sbjct: 2961 NGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTP-VIEYGTVNG 3019 Query: 2791 ENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGH-PGSPIYGRTSGN 2849 ++ QC GF+L+G S C+ D WS P C SCG P P + + Sbjct: 3020 TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETS 3079 Query: 2850 GFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIE 2909 + N V+T+SC GY++QG + C WS P P+C+ ++C P AN+ + Sbjct: 3080 SWKEN-VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAH 3138 Query: 2910 HGNFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSG 2968 TY + V C GY + + CQ +G+W C C P + ++ G Sbjct: 3139 ----TYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHG 3194 Query: 2969 EKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATG--TCGDPGTPGHGS 3026 + ++ V SC + G + CQL+G W +P S ++ +CG P +P HG Sbjct: 3195 DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW---EPPFSDESCSPVSCGKPESPEHGF 3251 Query: 3027 RQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVF 3086 S + +ST+ Y C+ GY L G+ ER C N W+G CK +C P NGK Sbjct: 3252 VVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKA- 3310 Query: 3087 RIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPG-IPANGLRY 3145 I+ T +V+YSC GY L GPS CT NGTWS +P C C P IP N L Sbjct: 3311 DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLS 3370 Query: 3146 GDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLE 3205 ++ V QNVS C+ G+ ++ +G I TC + TW+ C ++C P + N Sbjct: 3371 EKEFYVDQNVSIKCREGFLLQGHG--IITCNPDETWTQTSAKCEKISCGPPAHVENAIAR 3428 Query: 3206 GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTW-SGEVPQCLPKF-CGDPGIPAQGKRE 3263 G ++ +G I+Y C GY L C+ NGTW S + + + +F C + GI +R Sbjct: 3429 GVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGI---CQRP 3485 Query: 3264 GKSFIYQSEVSFSCNFPFILVGS-------STRICQADGTWSGSSPH------------- 3303 + + C P ++ + C W+GS H Sbjct: 3486 NACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGK 3545 Query: 3304 CIEPTQTSCENPGVPRHGSQNNTFGF 3329 C+ P + C + + S+ GF Sbjct: 3546 CVRPNRCHCLSSWTGHNCSRKRRTGF 3571 Score = 360 bits (925), Expect = 1e-98 Identities = 240/766 (31%), Positives = 330/766 (43%), Gaps = 79/766 (10%) Query: 2738 GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRD 2797 GS CD GF LVG+ V+ CL+ G W++ C CG+P + NG +++ Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGS 1710 Query: 2798 TVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCV-------------------------- 2831 TV YQCN G+ L+G S C + +W+G PSC+ Sbjct: 1711 TVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYIC 1770 Query: 2832 ---------------PVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQ 2876 P+ C PG+P G +SG + VTFSC GY + G TK C Sbjct: 1771 SCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL 1830 Query: 2877 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2936 + +W+H P CK V+C P IP N IE FT+G+ V Y CN GY L G Sbjct: 1831 ESGEWNHLIPYCKAVSCGKPAIPEN----GCIEELAFTFGSKVTYRCNKGYTLAGDKESS 1886 Query: 2937 CQPNGQWDKPLPECIMIDCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRT 2994 C N W P C + C P N +LSG T+ ST YSC SL G S Sbjct: 1887 CLANSSWSHSPPVCEPVKCSSPENINNGKYILSG--LTYLSTASYSCDTGYSLQGPSIIE 1944 Query: 2995 CQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEER 3054 C +G W + P C CG+P +NF ++TV Y C GY L G + Sbjct: 1945 CTASGIWDRAPPACH---LVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTI 2001 Query: 3055 TCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQ 3114 CLA+G W+ +C AV C P + F Y C +GY L+ S Sbjct: 2002 ECLADGKWSRSDQQCLAVSCDEPPIVDHASP-ETAHRLFGDIAFYYCSDGYSLADNSQLL 2060 Query: 3115 CTANGTW----SGTLPNCTIISCGDPGIPANGLRYG---DDYVVGQNVSYMCQPGYTMEL 3167 C A G W +P C C P + + + G VS+ C G+ L Sbjct: 2061 CNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFV--L 2118 Query: 3168 NGSRIRTCTINGTW--SGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYEL 3225 N S C G W S + C V C PP I NG G+N+ +G ++Y C+ G+ + Sbjct: 2119 NTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYI 2178 Query: 3226 SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKS-FIYQSEVSFSCNFPFILV 3284 TC G WS +P C P CG+P G E + I++SEV + CN + V Sbjct: 2179 KGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSV 2238 Query: 3285 GSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHL 3344 GS +CQA+ W SP P C P ++G F+VGS VQF C +G+ Sbjct: 2239 GSPVFVCQANRHWHSESPLMCVP--LDCGKPPPIQNGFMKGE-NFEVGSKVQFFCNEGYE 2295 Query: 3345 LQGSTTRTCLPDLTWS-GIQPECIPHSCKQPETPAHAN-VVGMDLPSHGYTLIYTCQPGF 3402 L G ++ TC W+ P+C+P C PE P N +V +L + + ++C+ G Sbjct: 2296 LVGDSSWTCQKSGKWNKKSNPKCMPAKC--PEPPLLENQLVLKELTTEVGVVTFSCKEGH 2353 Query: 3403 FLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRP--ALGTPSP 3446 L G + + C W P+C KI++ P P + G P P Sbjct: 2354 VLQGPSVLK-CLPSQQWNDSFPVC----KIVLCTPPPLISFGVPIP 2394 Score = 301 bits (772), Expect = 6e-81 Identities = 193/638 (30%), Positives = 279/638 (43%), Gaps = 67/638 (10%) Query: 2839 GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2898 GS + RT+ V C+ G+ + G C QW+ P P C+ ++C P Sbjct: 1636 GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPP 1695 Query: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMID---- 2954 N + +F G+ V Y CN GY+L G S + C NG W+ P C+ +D Sbjct: 1696 LENGFHSA----DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAV 1751 Query: 2955 -------------------------------------CGHPGVPPNAVLSGEKYTFGSTV 2977 C PG P N SGE YT G+ V Sbjct: 1752 GSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEV 1811 Query: 2978 HYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKST 3037 +SC L+G + TC +G W+ P+C +CG P P +G +E F S Sbjct: 1812 TFSCQEGYQLMGVTKITCLESGEWNHLIPYCK---AVSCGKPAIPENGCIEELAFTFGSK 1868 Query: 3038 VRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3097 V Y C+ GY L G +E +CLAN SW+ P C+ V+C +P NGK + + G T+ S+ Sbjct: 1869 VTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK-YILSGLTYLSTA 1927 Query: 3098 IYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSY 3157 YSC GY L GPS+ +CTA+G W P C ++ CG+P + + G+++ V+Y Sbjct: 1928 SYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTY 1987 Query: 3158 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISY 3217 C+ GYT L G C +G WS C AV+C PP + + E + +G Y Sbjct: 1988 TCKEGYT--LAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFY 2045 Query: 3218 ICSPGYELSFPAVLTCVGNGTW----SGEVPQCLPKFCGDPGIPAQGKREGKS---FIYQ 3270 CS GY L+ + L C G W ++P+C+ FC P + E S F Sbjct: 2046 YCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAG 2105 Query: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQ 3330 S VSF C F+L S+ C G W+ SP I+ C P +G + + + Sbjct: 2106 SVVSFKCMEGFVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGEPPSIMNGYASGS-NYS 2163 Query: 3331 VGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQP---ETPAHANVVGMDL 3387 G++V + C KG ++G TC WS P C P SC +P E + G Sbjct: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIF 2223 Query: 3388 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPI 3425 S + Y C PG+ G VC+++ W + P+ Sbjct: 2224 ESE---VRYQCNPGYKSVGSPVF-VCQANRHWHSESPL 2257 Score = 270 bits (690), Expect = 2e-71 Identities = 446/2055 (21%), Positives = 711/2055 (34%), Gaps = 362/2055 (17%) Query: 1161 GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPL 1219 G + C G++L G CL G+ W+ PLP C CG G + ++ Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQ--WTQPLPHCERISCGVPPPLENGFHSADDFYA 1708 Query: 1220 NYENNHECIYSIQVQAGKGINISARTFHLAQG----------DVLKIYDGKDKTTHLLGA 1269 ++C G + +R F G DV + G D + H Sbjct: 1709 GSTVTYQC------NNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHA--- 1759 Query: 1270 FTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQ 1329 + ++ G + S + D + E + C+ PG P+ G+ S + Sbjct: 1760 -SCLNVDGSYICSCVPP----YTGDGKNCAEPIK----------CKAPGNPENGHS-SGE 1803 Query: 1330 GHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSP 1389 + G+ + + C GY L G + + C+ E W++ +P C A G+ +G I Sbjct: 1804 IYTVGAEVTFSCQEGYQLMGVTKITCL--ESGEWNHLIPYCKAVSCGKPAIPENGCIEEL 1861 Query: 1390 GYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSL 1449 + F RC + G LA D E+S W P +K S Sbjct: 1862 AFTFGSKVTYRC------NKGYT-----LAGDKESSCLANSSWSHSPPVCEPVKCSS--- 1907 Query: 1450 IPEGIHSTLNIVT--IQFDTDFYISKSGFAIQFSSSVATA----------------CRDP 1491 PE I++ I++ T Y +G+++Q S + C +P Sbjct: 1908 -PENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEP 1966 Query: 1492 GVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGN 1551 + G+ +TV + C GY L G + I C+ W S C+A Sbjct: 1967 PAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK---WSRSDQQCLAVSCDE 2023 Query: 1552 LTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDG---- 1607 P H P + + D +S+ N L G Sbjct: 2024 ---------PPIVDHASPETAH-----RLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVP 2069 Query: 1608 -PDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSV----SYTGFHLEYKAKLR---- 1658 + P + K P S ++ A + GSV GF L AK+ Sbjct: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129 Query: 1659 --------------ESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMG 1704 C +P +IMNG G +Y G+ V Y C+ G+ ++G TC Sbjct: 2130 GQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTC--- 2186 Query: 1705 DDGRPGWNRALPSCH-APCGSRSTGSEGTVLSPN---YPKNYSVGHNCVYSIAVPKEFVV 1760 + W+ +P+CH CG G + + N Y FV Sbjct: 2187 -EATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC 2245 Query: 1761 FGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIR--FTSVGPI 1818 H + P +G GE+ + S Q + VG Sbjct: 2246 QA-----NRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDS 2300 Query: 1819 T---AKGFHFVYQAVPRTSSTQCSSVPEPRF--GRRIGNEFAVGSSVL-FDCNPGYILHG 1872 + K + ++ P+ +C PEP + + E V+ F C G++L G Sbjct: 2301 SWTCQKSGKWNKKSNPKCMPAKC---PEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQG 2357 Query: 1873 SIAIRCETVPNSLAQWNDSLPTC-IVPC----------------------------GGIL 1903 ++C +P+ QWNDS P C IV C GG Sbjct: 2358 PSVLKC--LPSQ--QWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFF 2413 Query: 1904 TKRKGTILSP-----GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYD- 1957 + T L P P + C +P G I VQ +++ + + ++ Sbjct: 2414 LRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGI-IDVQGLAYLSTALYTCKPGFEL 2472 Query: 1958 -------GGDN-----NAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSA-AGFHLEY 2004 G+N P + +LN + L++ ++ S GF LE Sbjct: 2473 VGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEG 2532 Query: 2005 TA-----------IGLDSC-----PEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS 2048 + + SC PQ +G G Y G ++ + C G+ + GH+ Sbjct: 2533 PSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHA 2592 Query: 2049 HITCMPGPVRRWNYPIPICL-AQCG-GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIG 2106 TC W+ IP C+ CG DF G + D + Sbjct: 2593 MQTCEES---GWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPH 2649 Query: 2107 FGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYS 2166 HL V + E + S + T++ P + L D + Sbjct: 2650 PPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPG-----YELLGNPVLICQEDGT 2704 Query: 2167 QNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLH 2226 N + L + P+ NGF+ + ++G + + C PG+ L G+ CL Sbjct: 2705 WNGSAPSCISIECDLPTAPE-----NGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLE 2759 Query: 2227 GVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINF 2285 +R W+ PRCEA+ C MNG+I Y + +C G +N Sbjct: 2760 --NRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYEC--------DPGYVLNG 2809 Query: 2286 TVLQT----------EPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILI---K 2332 T +T EPI + P + Q+ E Y+ + L+ + Sbjct: 2810 TERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGAR 2869 Query: 2333 FHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGN 2392 + + +R C PP + N +TE ++ + + C G+ L G Sbjct: 2870 SRVCLANGSWSGATPDCVPVR-CATPPQLANG--VTEGLDYGFMKEVTFHCHEGYILHGA 2926 Query: 2393 AILTCRLGERLQMDGAPPVCQ-VLC---------------------------PANELRLD 2424 LTC+ D P+C+ V C P +L + Sbjct: 2927 PKLTCQSDG--NWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGN 2984 Query: 2425 STGVILSPG-YPDSYPNLQMCAWSISVEKGYNITMFVEF-------FQTEKEFDVLQVYD 2476 S+ LS G + S P+ C S V + Y +F Q K F +L + Sbjct: 2985 SSRRCLSNGSWSGSSPSCLPCRCSTPVIE-YGTVNGTDFDCGKAARIQCFKGFKLLGL-- 3041 Query: 2477 GPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPP 2536 S + G +SS F +H + C + P Sbjct: 3042 -----SEITCEADGQWSSGFP------------HCEHTS-------------CGSLPMIP 3071 Query: 2537 HGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK 2596 + + IS+T +V+ ++C G+ + G S +C + W P P C+ +SCG P Sbjct: 3072 NAF-ISETSSWKENVITYSCRSGYVIQGSSDLICTEKG----VWSQPYPVCEPLSCGSPP 3126 Query: 2597 APTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPS 2656 + N + + V C +GY + + + T CQ DG W + C CP Sbjct: 3127 SVANAVATGEAHTYESEVKLRCLEGYTMDT-DTDTFTCQKDGRWFPERIS--CSPKKCP- 3182 Query: 2657 INSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQI 2716 + E+ +V+G + +V SC GY G C +GTW C Sbjct: 3183 ----LPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSP 3238 Query: 2717 ISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGH 2776 +SCG+ +P +G +G++ ++ ST I+ C+ G+ L G+ R C + WS C Sbjct: 3239 VSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETR 3298 Query: 2777 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG 2836 C P +NG+ EN VVY CN G+ L G S C ++ WS +P C P C Sbjct: 3299 CETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCP 3358 Query: 2837 HP-GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSD 2895 P P S F + V+ C G+L+QG C + W+ C+ ++C Sbjct: 3359 VPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGP 3418 Query: 2896 PGIPANSKRESKIEHG-NFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMI- 2953 P + E+ I G ++ YG ++ Y C GY L G +C NG W P P C + Sbjct: 3419 P-----AHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSP-PICRAVC 3472 Query: 2954 --DCGHPGV--PPNAVLSGEKYTFGSTVHYSC-----TGKRSLLGQSSRTCQLNGHWSGS 3004 C + G+ PNA E + C G R + + C W+GS Sbjct: 3473 RFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCV---APYQCDCPPGWTGS 3529 Query: 3005 QPHCSGDATGTCGDP 3019 + H T C P Sbjct: 3530 RCH-----TAVCQSP 3539 Score = 124 bits (311), Expect = 2e-27 Identities = 323/1571 (20%), Positives = 522/1571 (33%), Gaps = 340/1571 (21%) Query: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPT---CDALCGGDVRGPSGTILSPG 1042 F+ GS VSF C G+ L+ + C + W+ P P C + G+ P Sbjct: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGE---------PPS 2151 Query: 1043 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLP 1102 Y + N ++ V + F + + T S P P Sbjct: 2152 IMNGYASGSNYSFGAMVAYSCNKGF----YIKGEKKSTCEATGQWSSPIPTCHPVSCGEP 2207 Query: 1103 PTINAGLYGN-----FRAQLRFISDFSISYEGFNITFSEYNLE------------PCEDP 1145 P + G + F +++R+ + G + + N C P Sbjct: 2208 PKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKP 2267 Query: 1146 GIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPL-PRCV-AECGA 1203 Q G G NF +G + F C+ GY L G S C G+ W+ P+C+ A+C Sbjct: 2268 PPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK--WNKKSNPKCMPAKC-- 2323 Query: 1204 SATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKT 1263 P PL N + + + G + S + H+ QG + Sbjct: 2324 -----------PEPPLL--ENQLVLKELTTEVGV-VTFSCKEGHVLQGPSV--------- 2360 Query: 1264 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFG 1323 L +Q W ++ F + ++ C P + FG Sbjct: 2361 ----------------LKCLPSQQW----------NDSFPVC----KIVLCTPPPLISFG 2390 Query: 1324 YKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESS 1383 I GST+ Y C G+ L G+S C W PLP C+ + + + Sbjct: 2391 VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG--TWSSPLPECVPVECPQPEEIPN 2448 Query: 1384 GRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLK 1443 G I G + C E+ GN +L E H W G ++ Sbjct: 2449 GIIDVQGLAYLSTALYTCKPGFEL-VGNTTTLC-----GENGH-----WLGGKPTCKAIE 2497 Query: 1444 EISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV----------------ATA 1487 + I G S ++ Q T Y GF ++ S++ A Sbjct: 2498 CLKPKEILNGKFSYTDLHYGQTVT--YSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIH 2555 Query: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA- 1546 C P NG G G +++ C PG+++ G TC + W S P C+ Sbjct: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG----WSSSIPTCMPI 2611 Query: 1547 PCG----------GNLTGSSGFILSPN--------FPHPYPHSRDC--DWTITVNADYVI 1586 CG L G+ + PHP H W T + Sbjct: 2612 DCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATH 2671 Query: 1587 SLAF-----ISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSD 1641 S F +S++ P Y+ L +P+ L + D Sbjct: 2672 SSNFLYGTMVSYTCNPGYELL--------GNPV---------------------LICQED 2702 Query: 1642 GSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTC 1701 G+ + + + + C P NG + +GS V Y C G++L G C Sbjct: 2703 GTWNGSA-----PSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLC 2757 Query: 1702 IMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVV 1760 + W+ A P C A C + G++ NY ++ + C +V+ Sbjct: 2758 LENRK----WSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYEC------DPGYVL 2807 Query: 1761 FG--QFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPI 1818 G + D E P SS S +G G+ Q I +T Sbjct: 2808 NGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTF----QKEIEYTCNEGF 2863 Query: 1819 TAKGFHFVY--------QAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYIL 1870 +G A P +C++ P+ G G ++ V F C+ GYIL Sbjct: 2864 LLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYIL 2923 Query: 1871 HGSIAIRCETVPNSLAQWNDSLPTC-IVPCG-----------GILTKRKGTI---LSPGY 1915 HG+ + C++ N W+ +P C V CG G G I PGY Sbjct: 2924 HGAPKLTCQSDGN----WDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGY 2979 Query: 1916 PEPYDNNLNCV----WKITVPE--GAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSY 1969 +++ C+ W + P V+ + T + D +D G A R+ + Sbjct: 2980 KLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTD----FDCG--KAARIQCF 3033 Query: 1970 SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYM 2029 G + L T ++D S+ H E+T+ G P P++ I + Sbjct: 3034 KGFKLLGLSEITC-------EADGQWSSGFPHCEHTSCG----SLPMIPNAFISETSSWK 3082 Query: 2030 VGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMSDFSGVILSPGFP 2088 +V+++ C GY +QG S + C V W+ P P+C CG S + V + G Sbjct: 3083 -ENVITYSCRSGYVIQGSSDLICTEKGV--WSQPYPVCEPLSCGSPPSVANAV--ATGEA 3137 Query: 2089 GNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVR-SGSSETSTVIGRLSGPQIP 2147 Y S + + G+ + F+ + + R S S + + ++ + Sbjct: 3138 HTYESEV----KLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVH 3193 Query: 2148 SSLFSTTHETSLYFHSDYSQNKQGFHIVY-----------QAYQLQSCPDPRPFRNGFVI 2196 FS + S+ Y+ + ++ SC P +GFV+ Sbjct: 3194 GDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVV 3253 Query: 2197 GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC-EALCGGNITAMNG--- 2252 G+ +T TI ++C PGY L GN C +R W+ + C E C + +NG Sbjct: 3254 GSKYTFESTIIYQCEPGYELEGNRERVCQE--NRQWSGGVAICKETRCETPLEFLNGKAD 3311 Query: 2253 ---------TIYS--PGYPDEYPNFQDC----FWLVRVP--PGNGIYINFTVLQTEPIYD 2295 +YS GY E P+ C W VP N + F + Sbjct: 3312 IENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVI-------- 3363 Query: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRV- 2354 P+ S E + + IK F G +++ + + Sbjct: 3364 ------------PENALLS-----EKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQ 3406 Query: 2355 ---------CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQM 2405 C PP V NA + ++ GD+I Y C G+ L G C Sbjct: 3407 TSAKCEKISCGPPAHVENA--IARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWT- 3463 Query: 2406 DGAPPVCQVLC 2416 +PP+C+ +C Sbjct: 3464 --SPPICRAVC 3472 Score = 107 bits (268), Expect = 2e-22 Identities = 296/1393 (21%), Positives = 465/1393 (33%), Gaps = 236/1393 (16%) Query: 957 KIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWW 1016 KI +S+ + L +P H R D GS V+ CD G++L C W Sbjct: 1620 KIDSKSIFCSDCPRLGGSVP-HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQW 1678 Query: 1017 SHPLPTCDAL-CGGDVRGPSGTILSPGY---PEFYPNSLNCTWTVDVTHGKGVQFNFHTF 1072 + PLP C+ + CG V P L G+ +FY S VT+ Q N + Sbjct: 1679 TQPLPHCERISCG--VPPP----LENGFHSADDFYAGS-------TVTY----QCNNGYY 1721 Query: 1073 HLEDHHDYLLITENGSFTQPLAR-------LTGSDLPPTINAGLYGNFRAQLRFISDFSI 1125 L D + T+NGS+ GSD + +I Sbjct: 1722 LLGDSR--MFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASC-----LNVDGSYICSCVP 1774 Query: 1126 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG 1185 Y G +E C+ PG P+ G G + +G +TFSC GY+L G ++I CL Sbjct: 1775 PYTGDGKNCAE--PIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES 1832 Query: 1186 GRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISAR 1244 G W+ +P C A CG A G + + + + C + K + A Sbjct: 1833 GE--WNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLAN 1890 Query: 1245 TFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQ-----LWLEFNSDTEGTD 1299 + V + G + + GLT ST++ L+ S E T Sbjct: 1891 SSWSHSPPVCEPVKCSSPENINNGKYI---LSGLTYLSTASYSCDTGYSLQGPSIIECTA 1947 Query: 1300 EG-FQLVYTSFELSHCEDPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMT 1357 G + + L C +P P + +F +T+ Y C GYTL G ++C+ Sbjct: 1948 SGIWDRAPPACHLVFCGEP--PAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLA 2005 Query: 1358 GERRAWDYPLPSCIA--------------ECGGRFKGESSGRILSPGYPFPYDNNLRCMW 1403 + W C+A E R G+ + S GY ++ L C Sbjct: 2006 DGK--WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNA 2063 Query: 1404 MIEVDPGNIVSL-----QFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIP----EGI 1454 + P + F S+ IL E+ K +GS++ EG Sbjct: 2064 QGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL-------ESVSKAKFAAGSVVSFKCMEGF 2116 Query: 1455 HSTLNI-VTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQ 1513 LN I+ + S +IQ + C +P MNG +G G V + Sbjct: 2117 --VLNTSAKIECMRGGQWNPSPMSIQ---CIPVRCGEPPSIMNGYASGSNYSFGAMVAYS 2171 Query: 1514 CDPGYELQGEERITCIQVENRYFWQPSPPVC-IAPCGGNLTGSSGFILSPNFPHPYPHSR 1572 C+ G+ ++GE++ TC E W P C CG +GF+ H Sbjct: 2172 CNKGFYIKGEKKSTC---EATGQWSSPIPTCHPVSCGEPPKVENGFL-----EHTTGRIF 2223 Query: 1573 DCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLP-------- 1624 + + N Y S+ F + N + S SPL+ D P Sbjct: 2224 ESEVRYQCNPGYK-SVGSPVFVCQANRHW-------HSESPLMCVPLDCGKPPPIQNGFM 2275 Query: 1625 --ERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK---------LRESCFDPGNIMNGTRL 1673 E E S V + + + K + C +P + N L Sbjct: 2276 KGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVL 2335 Query: 1674 GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTV 1733 VT+ C G+VLQG S L C+ WN + P C + Sbjct: 2336 KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVC-------------KI 2378 Query: 1734 LSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV-------FFQTSLHDVVEVYDGPTQQSS 1786 + P S G + +P + FG V FF + DG T S Sbjct: 2379 VLCTPPPLISFG------VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG-TWSSP 2431 Query: 1787 LLSSLS-GSHSGESLPLSSGNQITIRFTSVGPITAK-GFHFVYQAV-------------P 1831 L + E +P + + + S T K GF V P Sbjct: 2432 LPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP 2491 Query: 1832 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRC-ETVPNSLAQWND 1890 + +C E G+ + G +V + CN G+ L G A+ C ET W+ Sbjct: 2492 TCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLET-----GDWDV 2546 Query: 1891 SLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN 1949 P+C + C + G+ E D + + + G + + E Sbjct: 2547 DAPSCNAIHCD------SPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG 2600 Query: 1950 WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNL-----YLNFQSDIS-----VSAAG 1999 W S + P PH+ L Y + D+ Sbjct: 2601 WSS---------SIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPP 2651 Query: 2000 FHLEYTAIGLDSCPE-PQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVR 2058 +HL A ++ E P T SS ++ G +VS+ C+ GY L G+ + C Sbjct: 2652 YHLGAVAKTWENTKESPATHSS------NFLYGTMVSYTCNPGYELLGNPVLICQEDGT- 2704 Query: 2059 RWNYPIPICLA-QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS 2117 WN P C++ +C + +G + C ++ G + L N Sbjct: 2705 -WNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCK-PGHILAGSDLRLCLENRK 2762 Query: 2118 TETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD-----------YS 2166 E S + G + G + T+ ++LY+ D Sbjct: 2763 WSGASPRCEAISCKKPNPVMNGSIKGS-------NYTYLSTLYYECDPGYVLNGTERRTC 2815 Query: 2167 QNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLH 2226 Q+ + + C P NG V G+++T + I + C G+ L G + CL Sbjct: 2816 QDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCL- 2874 Query: 2227 GVSRNWNHPLPRC 2239 + +W+ P C Sbjct: 2875 -ANGSWSGATPDC 2886 Score = 105 bits (261), Expect = 1e-21 Identities = 253/1208 (20%), Positives = 414/1208 (34%), Gaps = 286/1208 (23%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWS-DHRPVCK 504 C P +NG G +F +GS VQF C+E Y L G S TCQ+ + W+ P C Sbjct: 2264 CGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK----WNKKSNPKCM 2319 Query: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 C P P + Q+ +E E+G T + Sbjct: 2320 PAKC-------------PEPPLLEN------------------QLVLKELTTEVGVVTFS 2348 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 +G VL G P ++ + SQ W ++ + C Sbjct: 2349 CKEG----------HVLQG---PSVLKCLPSQQW--------------NDSFPVCKIVLC 2381 Query: 625 GDPGTPLYGIR-EGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICI-FPCL 682 P +G+ +++ C GF L G + +CQ + WS+ +P C+ C Sbjct: 2382 TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECP 2441 Query: 683 SNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD- 741 P G + +G ++T PG F+L L ++G Sbjct: 2442 QPEEIPNGII----DVQGLAYLSTALYT--CKPG---------FELVGNTTTLCGENGHW 2486 Query: 742 -------------SPESPILGTFTGAEVPSHLT---SNSHILRLEFQADHSMSGRG-FNI 784 P+ + G F+ ++ T S + RLE + + G +++ Sbjct: 2487 LGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDV 2546 Query: 785 TYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMW 844 + C P N G ++ G+ I C GF + G TC + W Sbjct: 2547 DAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGF-QVAGHAMQTC----EESGW 2601 Query: 845 SGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTEL 904 S IP C ++C + G K+ ++ E Sbjct: 2602 SSSIPTC-------------------------MPIDCGLPPHIDFGDCTKLKDDQGYFEQ 2636 Query: 905 NYDVLEV----HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 960 D++EV P L + ++ T+ S SNF+Y T + N G+++ Sbjct: 2637 EDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHS-SNFLY--GTMVSYTCNPGYELLG 2693 Query: 961 ESVTV---------NTYSCLD-----PGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEE 1006 V + + SC+ P P +G + S+GS V +SC G+ L+ + Sbjct: 2694 NPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSD 2753 Query: 1007 PLLCEKNHWWSHPLPTCDAL--------CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVD 1058 LC +N WS P C+A+ G ++G + T LS Y E P + ++ Sbjct: 2754 LRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPG-----YVLN 2808 Query: 1059 VTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPP-TINAGLYGN---FR 1114 T + Q + +N +P+ PP + N + G+ F+ Sbjct: 2809 GTERRTCQDD----------------KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQ 2852 Query: 1115 AQLRFISDFSISYEGFNITFSEYNLE-----------PCEDPGIPQYGSRIGFNFGIGDT 1163 ++ + + EG N C P G G ++G Sbjct: 2853 KEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKE 2912 Query: 1164 LTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYE 1222 +TF C GY L G ++ C G W A +P C CG L+ +P + Sbjct: 2913 VTFHCHEGYILHGAPKLTCQSDGN--WDAEIPLCKPVNCGPPED------LAHGFPNGFS 2964 Query: 1223 NNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSS 1282 H IQ Q G K++ + G+++G+S L Sbjct: 2965 FIHG--GHIQYQCFPG---------------YKLHGNSSRRCLSNGSWSGSSPSCLPCRC 3007 Query: 1283 TSNQLWLEFNSDTEGTD------------EGFQLV-----------YTSFELSHCED--- 1316 ++ +E+ + GTD +GF+L+ S HCE Sbjct: 3008 STPV--IEYGT-VNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSC 3064 Query: 1317 ---PGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1373 P IP IS+ + + I Y C GY + GSS L C E+ W P P C Sbjct: 3065 GSLPMIP--NAFISETSSWKENVITYSCRSGYVIQGSSDLICT--EKGVWSQPYPVCEPL 3120 Query: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCM--WMIEVDPGNIVSLQFLAFDTEASHDILRV 1431 G ++ + + + LRC+ + ++ D + + E R+ Sbjct: 3121 SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPE------RI 3174 Query: 1432 WDGP-----PENDMLL----------KEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGF 1476 P PEN + +++S S +NI Q D + + F Sbjct: 3175 SCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW---EPPF 3231 Query: 1477 AIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYF 1536 + + S V +C P P +G G T+++QC+PGYEL+G C ENR Sbjct: 3232 SDESCSPV--SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC--QENRQ- 3286 Query: 1537 WQPSPPVC 1544 W +C Sbjct: 3287 WSGGVAIC 3294 Score = 89.7 bits (221), Expect = 5e-17 Identities = 73/289 (25%), Positives = 117/289 (40%), Gaps = 41/289 (14%) Query: 2685 CDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFT 2744 C+ GY+G G EC + +++ E I SC +P P + + GST+ Sbjct: 307 CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSC--IPCPDENHT----SPPGSTS--- 356 Query: 2745 CDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGE--NYGYRDTVVYQ 2802 +C+ + S C HC + NG I N + + Sbjct: 357 -----------PEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR 405 Query: 2803 CNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGR--TSGNGFNFNDVVTFS 2860 C+PGF L+GSS+ +C + WSG C +C H P +G S + + Sbjct: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465 Query: 2861 CNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPAN--------SKRESKIEHGN 2912 C+ GY ++G K CQ N QW P P C +CS +P + K+ +K Sbjct: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK----- 520 Query: 2913 FTYGTVVFYDCNPGYFLFG-SSVLICQPNGQWDKPLPECIMIDCGHPGV 2960 +GT+ + C G+ L G +L C +G+W+ + + D P + Sbjct: 521 --FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQI 567 Score = 85.5 bits (210), Expect = 9e-16 Identities = 234/1067 (21%), Positives = 373/1067 (34%), Gaps = 201/1067 (18%) Query: 396 ERTKELAVVTHRVKKAIDFKSRG-FKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPEN 454 E T E+ VVT K+ + K P + ++ F + LC P Sbjct: 2337 ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK-------IVLCTPPPLISF 2389 Query: 455 GKRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQ 513 G I S GSTV++SC + L+G + CQ WS P C C + Sbjct: 2390 GVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQ----PDGTWSSPLPECVPVECPQPEE 2445 Query: 514 GPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGE-VG 572 P+G ++ TA+ T K F+L +G T G+ G +G Sbjct: 2446 IPNGIIDVQGL----------AYLSTALYTCK------PGFEL-VGNTTTLCGENGHWLG 2488 Query: 573 DPRTV--------LQVLTGSF-VPDL----IVSMSSQMWLHLQTDESVGSV---GFKVNY 616 T ++L G F DL V+ S L+ ++ + + V+ Sbjct: 2489 GKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDA 2548 Query: 617 KEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPI 676 C P G EG +S ++ + C GF++ G C+E+ WS++IP Sbjct: 2549 PSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPT 2607 Query: 677 CIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLA 736 C+ P+ L P G L + + + +A Sbjct: 2608 CM---------PIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVA 2658 Query: 737 VKDGDSPESPIL--GTFTGAEVPSHLTSNSHILR----LEFQADHSMSGRGFNITYNTFG 790 ++ ESP F + S+ + + L L Q D + +G + Sbjct: 2659 KTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCI----- 2713 Query: 791 HNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPK 850 EC P P N +GS++ C+ G I G++ C+ WSG P+ Sbjct: 2714 SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHI-LAGSDLRLCL---ENRKWSGASPR 2769 Query: 851 CGA-PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFER-FQTELNYDV 908 C A C +G I + Y +L E +PG+ + T R Q + N+D Sbjct: 2770 CEAISCKKPNPVMNGSIKGSNYT--YLSTL----YYECDPGYVLNGTERRTCQDDKNWDE 2823 Query: 909 LEVHDGP-NLLSPLLGSYNGTQVPQFLFSSSNFIYLL---FTTDNSRSN----NGFKIHY 960 E P + SP + + + ++ F Y F + +RS NG + Sbjct: 2824 DEPICIPVDCSSPPVSANGQVRGDEYTF-QKEIEYTCNEGFLLEGARSRVCLANG---SW 2879 Query: 961 ESVTVN--TYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSH 1018 T + C P +G G D+ V+F C GY L L C+ + W Sbjct: 2880 SGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDA 2939 Query: 1019 PLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFN-FHTFHLEDH 1077 +P C + G L+ G+P + HG +Q+ F + L + Sbjct: 2940 EIPLCKPVNCGPPED-----LAHGFPNGF----------SFIHGGHIQYQCFPGYKLHGN 2984 Query: 1078 HDYLLITENGSFTQPLARLTGSDLP-----PTINAGLYGNFRAQLRFISDFSIS------ 1126 ++ NGS++ + S LP P I G +DF Sbjct: 2985 SSRRCLS-NGSWSGS----SPSCLPCRCSTPVIEYGTVNG--------TDFDCGKAARIQ 3031 Query: 1127 -YEGFNIT-FSEYNLEP----------CED------PGIPQYGSRIGFNFGIGDT----- 1163 ++GF + SE E CE P IP N I +T Sbjct: 3032 CFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIP--------NAFISETSSWKE 3083 Query: 1164 --LTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLN 1220 +T+SC SGY ++G+S++IC G VWS P P C CG+ + + + Sbjct: 3084 NVITYSCRSGYVIQGSSDLICTEKG--VWSQPYPVCEPLSCGSPPSVANAVATGEAHTYE 3141 Query: 1221 YENNHECI--YSIQVQAG------------KGINISARTFHLAQGDVLKIYDGKDKTTH- 1265 E C+ Y++ + I+ S + L + + G D + + Sbjct: 3142 SEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNR 3201 Query: 1266 --LLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFG 1323 + G + G+ +S L+ + +DE V C P P+ G Sbjct: 3202 QVSVSCAEGYTFEGVNISVCQ----LDGTWEPPFSDESCSPV-------SCGKPESPEHG 3250 Query: 1324 YKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1370 + + + F STIIY C PGY L G+ C E R W + C Sbjct: 3251 FVVGSKYTFE-STIIYQCEPGYELEGNRERVCQ--ENRQWSGGVAIC 3294 Score = 78.6 bits (192), Expect = 1e-13 Identities = 139/641 (21%), Positives = 224/641 (34%), Gaps = 119/641 (18%) Query: 802 NARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC--------GA 853 N D+F GS+++ C G+ G + C W+G+ P C G+ Sbjct: 1698 NGFHSADDFYAGSTVTYQCNNGYYLL-GDSRMFCT---DNGSWNGVSPSCLDVDECAVGS 1753 Query: 854 PCGGHFSAPS--GVILSPGWPGYYKDSLNCEWVIEAE-PGHSIKITFERFQTELNYDVLE 910 C H S + G + P Y D NC I+ + PG+ E + E Sbjct: 1754 DCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNP----------ENGHSSGE 1803 Query: 911 VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 970 ++ T + FS L+ T + +G H SC Sbjct: 1804 IY---------------TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC-KAVSC 1847 Query: 971 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL-CGG 1029 P IP +G F+ GS V++ C+ GY L+ ++ C N WSH P C+ + C Sbjct: 1848 GKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS 1907 Query: 1030 DVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1089 +G + G +T+ ++ T + + T +G + Sbjct: 1908 PENINNGKYILSG----------------LTYLSTASYSCDTGYSLQGPSIIECTASGIW 1951 Query: 1090 TQ--PLARLTGSDLPPTI-NAGLYGN---FRAQLRFISDFSISYEGFNI----------- 1132 + P L PP I +A + GN FR + + + G + Sbjct: 1952 DRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSR 2011 Query: 1133 TFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSA 1192 + + C++P I + S + GD + CS GY L S+++C G+ W Sbjct: 2012 SDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGK--WVP 2069 Query: 1193 P----LPRCVAE-CGASATNNEGILLS-----------------PNYPLNYENNHECIYS 1230 P +PRC+A C + + IL S + LN EC+ Sbjct: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129 Query: 1231 IQVQAGKGINISARTFHLAQGDVLKIYDG-KDKTTHLLGAFTGASM-RGLTLSSTSNQLW 1288 Q +S + + G+ I +G + + GA S +G + Sbjct: 2130 GQWNPSP---MSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKG------ 2180 Query: 1289 LEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLH 1348 E S E T + + T +S C +P + G+ G S + Y CNPGY Sbjct: 2181 -EKKSTCEATGQWSSPIPTCHPVS-CGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSV 2238 Query: 1349 GSSLLKCMTGERRAWDYPLPSCIAECG-------GRFKGES 1382 GS + C + PL +CG G KGE+ Sbjct: 2239 GSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN 2279 Score = 78.2 bits (191), Expect = 1e-13 Identities = 251/1237 (20%), Positives = 406/1237 (32%), Gaps = 316/1237 (25%) Query: 623 SCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 681 SCG+P G E G +R++C G++ +G VCQ N W + P+ Sbjct: 2203 SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPL----- 2257 Query: 682 LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVKDG 740 P+ P G+ N + GS++ N+ ++L + K G Sbjct: 2258 ---MCVPLDCGKPPPIQNGFMKGEN------FEVGSKVQFFCNEGYELVGDSSWTCQKSG 2308 Query: 741 -------------DSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSG-------- 779 PE P+L V LT+ ++ + H + G Sbjct: 2309 KWNKKSNPKCMPAKCPEPPLL---ENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLP 2365 Query: 780 -RGFNITYNTFGHNECPDP-----GIPINARRFGDNFQLGSSISVICEEGFIKTQGTETI 833 + +N ++ C P G+PI + GS++ C GF +G T Sbjct: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPIPS----SALHFGSTVKYSCVGGFF-LRGNSTT 2420 Query: 834 TCILMDGKVMWSGLIPKC-GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 892 C DG WS +P+C C P+G+I G Y +L +PG Sbjct: 2421 LC-QPDG--TWSSPLPECVPVECPQPEEIPNGIIDVQGL-AYLSTAL-----YTCKPG-- 2469 Query: 893 IKITFERFQTELNYDVLEVHDGPNL-LSPLLGSYNGTQVPQFLFSSSNFIYLLF-TTDNS 950 F+ N L +G L P + + + L ++ L + T Sbjct: 2470 -------FELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTY 2522 Query: 951 RSNNGFKIH--------------YESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSC 996 N GF++ ++ + N C P +G G D+S G+ + +SC Sbjct: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSC 2582 Query: 997 DSGYRLSHEEPLLCEKNHWWSHPLPTCDAL-CG-------GD---VRGPSG--------- 1036 G++++ CE++ WS +PTC + CG GD ++ G Sbjct: 2583 FPGFQVAGHAMQTCEES-GWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMM 2641 Query: 1037 --TILSPGYPEFYPNSLNCTW----------TVDVTHGKGVQFNFHTFHLEDHHDYLLIT 1084 ++P +P ++ ++ TW + + +G V + + + + L+ Sbjct: 2642 EVPYVTP-HPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700 Query: 1085 ENGSF--TQPLARLTGSDLPPTINAGL-------------YGNFRAQLRFISDFSISYEG 1129 E+G++ + P DLP G Y + SD + E Sbjct: 2701 EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760 Query: 1130 FNITFSEYNLE--PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGR 1187 + + E C+ P GS G N+ TL + C GY L GT C Sbjct: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDD-- 2818 Query: 1188 RVWSAPLPRCV-AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTF 1246 + W P C+ +C + + G + Y E + C Sbjct: 2819 KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTC------------------- 2859 Query: 1247 HLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTL-SSTSNQLWLEFNSDTEGTDEGFQLV 1305 +G +L+ + + G+++GA+ + + +T QL N TEG D GF Sbjct: 2860 --NEGFLLE--GARSRVCLANGSWSGATPDCVPVRCATPPQL---ANGVTEGLDYGFMKE 2912 Query: 1306 YTSFELSHCEDPGIPQFGYKISDQ-------------------------------GHFAG 1334 T HC + I K++ Q G Sbjct: 2913 VT----FHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHG 2968 Query: 1335 STIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFP 1394 I Y C PGY LHG+S +C++ +W PSC+ C R +P + Sbjct: 2969 GHIQYQCFPGYKLHGNSSRRCLS--NGSWSGSSPSCL-PC----------RCSTPVIEYG 3015 Query: 1395 YDNNLRCMWMIEVDPGNIVSLQ-FLAFDTEASHDILRVWDGPPENDM---------LLKE 1444 N + D G +Q F F +I DG + L Sbjct: 3016 TVNG------TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPM 3069 Query: 1445 ISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV----------------ATAC 1488 I + I E N++T Y +SG+ IQ SS + +C Sbjct: 3070 IPNAFISETSSWKENVIT-------YSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSC 3122 Query: 1489 RDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQP---SPPVCI 1545 P N G+ V +C GY + + Q + R+F + SP C Sbjct: 3123 GSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCP 3182 Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605 P N H H D +VN +S A Y + Sbjct: 3183 LP--------------ENITHILVHGDD----FSVNRQVSVSCA-----------EGYTF 3213 Query: 1606 DGPD-SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1664 +G + S L G+++ P ES S SC P Sbjct: 3214 EGVNISVCQLDGTWEP---PFSDESCSPV--------------------------SCGKP 3244 Query: 1665 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTC 1701 + +G +G Y ST+ Y C+ GY L+G C Sbjct: 3245 ESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC 3281 Score = 74.7 bits (182), Expect = 2e-12 Identities = 107/435 (24%), Positives = 159/435 (36%), Gaps = 83/435 (19%) Query: 1844 PRFG------RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIV 1897 PR G R + GS V C+PG+ L G+ C + QW LP C Sbjct: 1632 PRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCL----NQGQWTQPLPHC-- 1685 Query: 1898 PCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYD 1957 +S G P P +N + G+ + Q + +Y Sbjct: 1686 -----------ERISCGVPPPLENGFHSADDFYA--GSTVTYQCNN----------GYYL 1722 Query: 1958 GGDNN--APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLE----------YT 2005 GD+ GS++G + P L+ + SD S A+ +++ YT Sbjct: 1723 LGDSRMFCTDNGSWNGVS-PSCLDVDECAV----GSDCSEHASCLNVDGSYICSCVPPYT 1777 Query: 2006 AIGLD-----SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060 G + C P P +G G+ Y VG V+F C +GY L G + ITC+ W Sbjct: 1778 GDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES--GEW 1835 Query: 2061 NYPIPICLA-QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE 2119 N+ IP C A CG +G I F + C L G N S Sbjct: 1836 NHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTL-AGDKESSCLANSSWS 1894 Query: 2120 TIHDYLE-VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVY-- 2176 E V+ S E +G I S L T+ ++ + D + QG I+ Sbjct: 1895 HSPPVCEPVKCSSPENIN-----NGKYILSGL---TYLSTASYSCDTGYSLQGPSIIECT 1946 Query: 2177 ---------QAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHG 2227 A L C +P ++ + GN+FT T+++ C GYTL G + CL Sbjct: 1947 ASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECL-- 2004 Query: 2228 VSRNWNHPLPRCEAL 2242 W+ +C A+ Sbjct: 2005 ADGKWSRSDQQCLAV 2019 Score = 74.3 bits (181), Expect = 2e-12 Identities = 66/251 (26%), Positives = 95/251 (37%), Gaps = 30/251 (11%) Query: 3064 GRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGP---SVRQCTANGT 3120 G Q EC A G ++ +G+ S C + S P S C Sbjct: 315 GLQYECTACPSGT---------YKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREG 365 Query: 3121 WSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVS--YMCQPGYTMELNGSRIRTCTIN 3178 + + C ++ C P NG + N + C PG+ +L GS I C N Sbjct: 366 YRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF--DLVGSSIILCLPN 423 Query: 3179 GTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYI--CSPGYELSFPAVLTCVGN 3236 G WSG CR TCP Q +G + + + + + + C GY L LTC GN Sbjct: 424 GLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGN 483 Query: 3237 GTWSGEVPQCLPKFCGDPGIPAQ--------GKREGKSFIYQSEVSFSCNFPFILVGSST 3288 W G P+C+ + C +P GK+ K + + SC FIL G Sbjct: 484 SQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK---FGTICYVSCRQGFILSGVKE 540 Query: 3289 RI-CQADGTWS 3298 + C G W+ Sbjct: 541 MLRCTTSGKWN 551 Score = 74.3 bits (181), Expect = 2e-12 Identities = 49/157 (31%), Positives = 65/157 (41%), Gaps = 10/157 (6%) Query: 2973 FGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG--SRQES 3030 F + C L+G S C NG WSGS+ +C TC P HG S Sbjct: 398 FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCR---VRTCPHLRQPKHGHISCSTR 454 Query: 3031 NFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN----PGTTANGKVF 3086 K+T ACD GY L GS++ TC N W G +P C C + Sbjct: 455 EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNC 514 Query: 3087 RIDGTTFSSSVIYSCMEGYILSG-PSVRQCTANGTWS 3122 F + SC +G+ILSG + +CT +G W+ Sbjct: 515 GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551 Score = 73.6 bits (179), Expect = 3e-12 Identities = 68/245 (27%), Positives = 97/245 (39%), Gaps = 36/245 (14%) Query: 2825 GQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP 2884 G + SC+P + SP G TS D V C GY G T Sbjct: 335 GGISSCIPCPDENHTSPP-GSTSPE-----DCV---CREGYRASGQT------------- 372 Query: 2885 PPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWD 2944 C++V+C P N + +F V C+PG+ L GSS+++C PNG W Sbjct: 373 ---CELVHCPALKPPENGYFIQNTCNNHFNAACGV--RCHPGFDLVGSSIILCLPNGLWS 427 Query: 2945 KPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWS 3002 C + C H P + +S + + +T +C L G TCQ N W Sbjct: 428 GSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWD 487 Query: 3003 GSQPHCSGDATGTCGDPG----TPGHGSRQESNFRTKSTVRYACDTGYILHGSEER-TCL 3057 G +P C T P +P + +Q + F T V +C G+IL G +E C Sbjct: 488 GPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYV--SCRQGFILSGVKEMLRCT 545 Query: 3058 ANGSW 3062 +G W Sbjct: 546 TSGKW 550 Score = 73.6 bits (179), Expect = 3e-12 Identities = 101/450 (22%), Positives = 169/450 (37%), Gaps = 67/450 (14%) Query: 620 EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 679 E C PG P G G+ ++ + F CQ G++L+G I C E+ +W+ IP C Sbjct: 1785 EPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844 Query: 680 PCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVK 738 P PE CI + GS++ N + L + + Sbjct: 1845 VSCGK----------PAIPEN-----GCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889 Query: 739 DGDSPESPILGTFTGAEVPSHLTSNSHILR-------LEFQADHSMSGRGFNITYNTFGH 791 + SP + P ++ + +IL + D S +G +I T Sbjct: 1890 NSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG 1949 Query: 792 NE-----------CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDG 840 C +P +A G+NF ++++ C+EG+ G +TI C L DG Sbjct: 1950 IWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLA-GLDTIEC-LADG 2007 Query: 841 KVMWSGLIPKCGA------PCGGHFSAPSGVILSPGWPGYY---------KDSLNC---- 881 K WS +C A P H S + L YY L C Sbjct: 2008 K--WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQG 2065 Query: 882 EWVI-EAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNF 940 +WV E + F ++Y +LE + + S+ + F+ ++S Sbjct: 2066 KWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCME--GFVLNTSAK 2123 Query: 941 IYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGY 1000 I + N + + + V C +P ++G G ++S G+ V++SC+ G+ Sbjct: 2124 IECM----RGGQWNPSPMSIQCIPVR---CGEPPSIMNGYASGSNYSFGAMVAYSCNKGF 2176 Query: 1001 RLSHEEPLLCEKNHWWSHPLPTCDALCGGD 1030 + E+ CE WS P+PTC + G+ Sbjct: 2177 YIKGEKKSTCEATGQWSSPIPTCHPVSCGE 2206 Score = 71.2 bits (173), Expect = 2e-11 Identities = 54/195 (27%), Positives = 77/195 (39%), Gaps = 12/195 (6%) Query: 2816 ICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN--FNDVVTFSCNIGYLMQGPTKA 2873 +C++ + SGQ +C V C P G N N FN C+ G+ + G + Sbjct: 361 VCREGYRASGQ--TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418 Query: 2874 QCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS 2933 C N WS C+V C P + Y T C+ GY L GS Sbjct: 419 LCLPNGLWSGSESYCRVRTC--PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSD 476 Query: 2934 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS-----GEKYTFGSTVHYSCTGKRSLL 2988 L CQ N QWD P P C+ C +P + ++S + FG+ + SC L Sbjct: 477 KLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILS 536 Query: 2989 G-QSSRTCQLNGHWS 3002 G + C +G W+ Sbjct: 537 GVKEMLRCTTSGKWN 551 Score = 70.1 bits (170), Expect = 4e-11 Identities = 51/200 (25%), Positives = 82/200 (41%), Gaps = 15/200 (7%) Query: 3187 TCRAVTCPTPPQISNGR-LEGT-NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVP 3244 TC V CP NG ++ T N + + C PG++L +++ C+ NG WSG Sbjct: 372 TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSES 431 Query: 3245 QCLPKFCGDPGIPAQG--KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3302 C + C P G + +Y++ +C+ + L GS CQ + W G P Sbjct: 432 YCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP 491 Query: 3303 HCIEPTQTSCENPG---VPRHGSQNNTFGFQVGSVVQFHCKKGHLLQG-STTRTCLPDLT 3358 C+E ++ + P + H F G++ C++G +L G C Sbjct: 492 RCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLRCTTSGK 549 Query: 3359 WS-GIQPECIPHSCKQPETP 3377 W+ G+Q CK E P Sbjct: 550 WNVGVQAAV----CKDVEAP 565 Score = 70.1 bits (170), Expect = 4e-11 Identities = 52/195 (26%), Positives = 81/195 (41%), Gaps = 20/195 (10%) Query: 3277 CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVV 3335 C+ F LVGSS +C +G WSGS +C T C + P+HG + +T + Sbjct: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRT---CPHLRQPKHGHISCSTREMLYKTTC 462 Query: 3336 QFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV----VGMDLPSHG 3391 C +G+ L+GS TC + W G +P C+ C + P + G G Sbjct: 463 LVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG 522 Query: 3392 YTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLSVP 3451 +C+ GF L+G E C + W V + KD +P+++ P Sbjct: 523 TICYVSCRQGFILSGVKEMLRCTTSGKWNVGV------QAAVCKD------VEAPQINCP 570 Query: 3452 DDVFAQNYIWKGSYN 3466 D+ A+ + S N Sbjct: 571 KDIEAKTLEQQDSAN 585 Score = 65.5 bits (158), Expect = 9e-10 Identities = 68/272 (25%), Positives = 106/272 (38%), Gaps = 49/272 (18%) Query: 969 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALC 1027 SC P P HG G ++ ST+ + C+ GY L +C++N WS + C + C Sbjct: 3240 SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRC 3299 Query: 1028 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENG 1087 + EF + + T G V ++ + + + TENG Sbjct: 3300 ETPL-------------EFLNGKADIE---NRTTGPNVVYSCNRGYSLEGPSEAHCTENG 3343 Query: 1088 SFTQPLARLTGSDLPPTI----NAGLYGNFRAQLRFISDFSISY---EGFNI-------- 1132 +++ P+ + P NA L ++ F D ++S EGF + Sbjct: 3344 TWSHPVPLCKPNPCPVPFVIPENALL-----SEKEFYVDQNVSIKCREGFLLQGHGIITC 3398 Query: 1133 --------TFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLG 1184 T ++ C P + G ++ GD +T+SC SGY LEG +CL Sbjct: 3399 NPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE 3458 Query: 1185 GGRRVWSAPLPRCVAECGASATNNEGILLSPN 1216 G W++P P C A C N GI PN Sbjct: 3459 NG--TWTSP-PICRAVCRFPCQNG-GICQRPN 3486 Score = 58.5 bits (140), Expect = 1e-07 Identities = 75/307 (24%), Positives = 110/307 (35%), Gaps = 43/307 (14%) Query: 2995 CQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGS-EE 3053 C+ + G Q C+ +GT G+PG S S + + GS Sbjct: 307 CEKGYYGKGLQYECTACPSGTYKPEGSPGGIS---------SCIPCPDENHTSPPGSTSP 357 Query: 3054 RTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT---FSSSVIYSCMEGYILSGP 3110 C+ + C+ V C NG + I T F+++ C G+ L G Sbjct: 358 EDCVCREGYRASGQTCELVHCPALKPPENG--YFIQNTCNNHFNAACGVRCHPGFDLVGS 415 Query: 3111 SVRQCTANGTWSGTLPNCTIISCGDPGIPANG--------LRYGDDYVVGQNVSYMCQPG 3162 S+ C NG WSG+ C + +C P +G + Y +V C G Sbjct: 416 SIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA------CDEG 469 Query: 3163 YTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT---PPQI----SNGRLEGTNFDWGFSI 3215 Y +E GS TC N W G P C C T P + N + F +I Sbjct: 470 YRLE--GSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG---TI 524 Query: 3216 SYI-CSPGYELS-FPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEV 3273 Y+ C G+ LS +L C +G W+ V + K P I E K+ Q Sbjct: 525 CYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSA 584 Query: 3274 SFSCNFP 3280 + + P Sbjct: 585 NVTWQIP 591 Score = 58.2 bits (139), Expect = 2e-07 Identities = 31/89 (34%), Positives = 39/89 (43%), Gaps = 4/89 (4%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C PG PENG G +++G+ V FSC E Y L G ITC E W+ P CK Sbjct: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE----WNHLIPYCKA 1844 Query: 506 KTCGSNLQGPSGTFTSPNFPFQYDSNAQC 534 +CG +G F F +C Sbjct: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRC 1873 Score = 57.4 bits (137), Expect = 3e-07 Identities = 56/208 (26%), Positives = 82/208 (39%), Gaps = 27/208 (12%) Query: 2569 VCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGIL--TTDYLVGTRVTYFCNDGYRLSS 2626 VCR+ GY A C+ + C K P NG + T + C+ G+ L Sbjct: 361 VCRE---GYRASGQ---TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVG 414 Query: 2627 KELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYE--YKTKVVFS 2684 + +C +G WS C V TCP + +HG ++ S E YKT + + Sbjct: 415 SSII--LCLPNGLWSGSESY--CRVRTCPHLRQ--PKHGH---ISCSTREMLYKTTCLVA 465 Query: 2685 CDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPP----NGNKIGTQ-TSYGS 2739 CD GY G + C G W P C C P + + G Q +G+ Sbjct: 466 CDEGYRLEGSDKLTC--QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGT 523 Query: 2740 TAIFTCDLGFMLVG-SAVRECLSSGLWS 2766 +C GF+L G + C +SG W+ Sbjct: 524 ICYVSCRQGFILSGVKEMLRCTTSGKWN 551 Score = 57.0 bits (136), Expect = 3e-07 Identities = 94/421 (22%), Positives = 147/421 (34%), Gaps = 52/421 (12%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C P NGK I S + ST +SCD Y LQG I C W P C + Sbjct: 1905 CSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHL 1960 Query: 506 KTCGSNLQGPSGTFTSPNFPFQYDSNAQCV--WVITAVNTNKVIQ----INFEEFDLEIG 559 CG T NF F+ C + + ++T + + ++ L + Sbjct: 1961 VFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVS 2020 Query: 560 YDTLTIGDGGEVGDPRTVLQVLTGSFVPD-LIVSMSSQMWLHLQTDESVGSVGFKVNYKE 618 D I D + + + D ++ +SQ+ + Q + V G + Sbjct: 2021 CDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQ-GKWVPPEG--QDMPR 2077 Query: 619 IEKESCGDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP 675 C P + Y I E F+ V+ F+C GF L I C QW+ + P Sbjct: 2078 CIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS-P 2136 Query: 676 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDF 734 + I C+ P+ P GY + N + G+ + S N F ++ + Sbjct: 2137 MSI-QCI-----PVRCGEPPSIMNGYASGSNYSF------GAMVAYSCNKGFYIKGEKKS 2184 Query: 735 LAVKDGD-SPESPILGTFTGAEVP-------SHLTSNSHILRLEFQADHSMSGRG---FN 783 G S P + E P H T + +Q + G F Sbjct: 2185 TCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFV 2244 Query: 784 ITYNTFGHNECPDPGIPI---------NARRFGDNFQLGSSISVICEEGFIKTQGTETIT 834 N H+E P +P+ N G+NF++GS + C EG+ + G + T Sbjct: 2245 CQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGY-ELVGDSSWT 2303 Query: 835 C 835 C Sbjct: 2304 C 2304 Score = 57.0 bits (136), Expect = 3e-07 Identities = 58/255 (22%), Positives = 94/255 (36%), Gaps = 38/255 (14%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C P PE+G +GS ++ ST+ + C+ Y L+G + CQ + WS +CK Sbjct: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ----WSGGVAICKE 3296 Query: 506 KTCGSNLQGPSG------TFTSPN--------FPFQYDSNAQCVWVITAVNTNKVIQINF 551 C + L+ +G T PN + + S A C T + + + N Sbjct: 3297 TRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNP 3356 Query: 552 EEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVP--DLIVSMSSQMWLHLQTDESVGS 609 I + L + + D ++ G + +I + W Sbjct: 3357 CPVPFVIPENAL-LSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSA------ 3409 Query: 610 VGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ 669 + EK SCG P I G + D++ + C G+ L G VC EN Sbjct: 3410 --------KCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT 3461 Query: 670 WSAN---IPICIFPC 681 W++ +C FPC Sbjct: 3462 WTSPPICRAVCRFPC 3476 Score = 52.0 bits (123), Expect = 1e-05 Identities = 23/59 (38%), Positives = 30/59 (50%), Gaps = 4/59 (6%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 SCG P +P G + F G K+ Y C GY L G + +C+ANS SW P+C Sbjct: 1846 SCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANS----SWSHSPPVC 1900 Score = 51.2 bits (121), Expect = 2e-05 Identities = 43/139 (30%), Positives = 55/139 (39%), Gaps = 17/139 (12%) Query: 2529 CSTPESPPHGYIISQTGGQL-NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587 C P HG+I T L + ACD G+RL G C+ G WD P P C Sbjct: 438 CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQ----GNSQWDGPEPRC 493 Query: 2588 QAISCG---IPK----APTNGGILTTDYLVGTRVTYFCNDGYRLSS-KELTTAVCQSDGT 2639 C +PK +P N G + GT C G+ LS KE+ C + G Sbjct: 494 VERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLR--CTTSGK 549 Query: 2640 WSNHNKTPRCVVVTCPSIN 2658 W+ + C V P IN Sbjct: 550 WNVGVQAAVCKDVEAPQIN 568 Score = 48.9 bits (115), Expect = 9e-05 Identities = 24/61 (39%), Positives = 32/61 (52%), Gaps = 5/61 (8%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 SCG P + G + GD I YSC +GY+L+G + C+ N +W P PICR Sbjct: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLEN----GTWTSP-PICR 3469 Query: 197 A 197 A Sbjct: 3470 A 3470 Score = 47.4 bits (111), Expect = 3e-04 Identities = 54/251 (21%), Positives = 82/251 (32%), Gaps = 59/251 (23%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC-K 504 C P ENG DF GSTV + C+ Y L G + C +W+ P C Sbjct: 1690 CGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTD----NGSWNGVSPSCLD 1745 Query: 505 VKTCG--------SNLQGPSGTFTSPNFPFQYDSNAQCVWVI---------TAVNTNKVI 547 V C ++ G++ P C I ++ ++ Sbjct: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIY 1805 Query: 548 QINFE-EFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDES 606 + E F + GY + + I + S W HL Sbjct: 1806 TVGAEVTFSCQEGYQLMGV----------------------TKITCLESGEWNHL----- 1838 Query: 607 VGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQE 666 + Y + SCG P P G E F+ + + C G+ L G+K C Sbjct: 1839 -------IPY--CKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889 Query: 667 NNQWSANIPIC 677 N+ WS + P+C Sbjct: 1890 NSSWSHSPPVC 1900 Score = 45.8 bits (107), Expect = 8e-04 Identities = 27/103 (26%), Positives = 42/103 (40%), Gaps = 2/103 (1%) Query: 3325 NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV-V 3383 NT + C G L GS+ CLP+ WSG + C +C P H ++ Sbjct: 392 NTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISC 451 Query: 3384 GMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3426 + T + C G+ L G++ C+ ++ W G P C Sbjct: 452 STREMLYKTTCLVACDEGYRLE-GSDKLTCQGNSQWDGPEPRC 493 Score = 45.1 bits (105), Expect = 0.001 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 5/80 (6%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 C PG P G G + VG ++ +SC GY L G ++TC+ + W+ +P C+A Sbjct: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL----ESGEWNHLIPYCKA 1844 Query: 198 EDACGGTMRGSSGIISSPSF 217 +CG +G I +F Sbjct: 1845 V-SCGKPAIPENGCIEELAF 1863 Score = 45.1 bits (105), Expect = 0.001 Identities = 97/424 (22%), Positives = 157/424 (37%), Gaps = 50/424 (11%) Query: 453 ENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNL 512 E G G+DF G + C + + L G ITC E WS P C+ +CGS Sbjct: 3013 EYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITC----EADGQWSSGFPHCEHTSCGSLP 3068 Query: 513 QGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGY--DTLTIGDGGE 570 P+ + + + N + + + VIQ + + E G + + Sbjct: 3069 MIPNAFISETS---SWKENV----ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLS 3121 Query: 571 VGDPRTVLQ-VLTG-SFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPG 628 G P +V V TG + + V + + TD + + E+ SC Sbjct: 3122 CGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFP-ERISCSPKK 3180 Query: 629 TPL-----YGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683 PL + + GD FS + C G+ G VCQ + W P Sbjct: 3181 CPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEP-------PFSD 3233 Query: 684 NFTAPM--GTVLSPDYPEGYGNNLNCIWTII--SDPGSRIHLSFNDFDLESQ--FDFLAV 737 +P+ G SP++ G+ TII +PG + + E++ +A+ Sbjct: 3234 ESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAI 3293 Query: 738 KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRG-FNITYN-TFGH---- 791 E+P+ A++ + T + + +S+ G + T N T+ H Sbjct: 3294 CKETRCETPLEFLNGKADIENRTTGPNVVYSCN--RGYSLEGPSEAHCTENGTWSHPVPL 3351 Query: 792 ---NECPDPG-IPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 847 N CP P IP NA F + ++S+ C EGF+ QG ITC + W+ Sbjct: 3352 CKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFL-LQGHGIITC---NPDETWTQT 3407 Query: 848 IPKC 851 KC Sbjct: 3408 SAKC 3411 Score = 43.9 bits (102), Expect = 0.003 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 5/90 (5%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 C P GV G + ++ + C GYIL G P+LTC ++ +WD +P+C+ Sbjct: 2891 CATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSD----GNWDAEIPLCKP 2946 Query: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADC 227 + CG + G + SF + H C Sbjct: 2947 VN-CGPPEDLAHGFPNGFSFIHGGHIQYQC 2975 Score = 43.5 bits (101), Expect = 0.004 Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 CG P G G+ + G + YSC G+ + G + TC A T W P+P C Sbjct: 2146 CGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEA----TGQWSSPIPTCHP 2201 Query: 198 EDACGGTMRGSSGII 212 +CG + +G + Sbjct: 2202 V-SCGEPPKVENGFL 2215 Score = 42.7 bits (99), Expect = 0.007 Identities = 23/65 (35%), Positives = 31/65 (47%), Gaps = 4/65 (6%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C P PENG F+ GS V + C++ Y L G K +C ++WS PVC+ Sbjct: 1847 CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL----ANSSWSHSPPVCEP 1902 Query: 506 KTCGS 510 C S Sbjct: 1903 VKCSS 1907 Score = 42.0 bits (97), Expect = 0.011 Identities = 17/59 (28%), Positives = 28/59 (47%) Query: 620 EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICI 678 E+ SCG P G D F + ++C G+ L+G+ + C +N W+ P C+ Sbjct: 1686 ERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCL 1744 Score = 41.6 bits (96), Expect = 0.015 Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 2/54 (3%) Query: 1163 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPN 1216 T +C GYRLEG+ ++ C G + W P PRCV ++ + +++SP+ Sbjct: 461 TCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCVERHCSTFQMPKDVIISPH 512 Score = 40.8 bits (94), Expect = 0.025 Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 4/66 (6%) Query: 131 EELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 E SCG P P G + G+++ I Y C GY L+G+ + C N W Sbjct: 3234 ESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQEN----RQWSG 3289 Query: 191 PVPICR 196 V IC+ Sbjct: 3290 GVAICK 3295 Score = 39.3 bits (90), Expect = 0.073 Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 3/47 (6%) Query: 2199 DFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CG 2244 D G ++ C PG+ L+GN CL+ W PLP CE + CG Sbjct: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLN--QGQWTQPLPHCERISCG 1691 Score = 38.9 bits (89), Expect = 0.095 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 4/99 (4%) Query: 2011 SCPEPQTPSSG-IKIGDRYMVGDVVSF-QCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2068 +CP + P G I R M+ CD+GY L+G +TC +W+ P P C+ Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGN--SQWDGPEPRCV 494 Query: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF 2107 + VI+SP G P+ ++ GF Sbjct: 495 ERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGF 533 Score = 38.9 bits (89), Expect = 0.095 Identities = 18/52 (34%), Positives = 24/52 (46%) Query: 990 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 1041 +T +CD GYRL + L C+ N W P P C + P I+SP Sbjct: 460 TTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511 Score = 38.9 bits (89), Expect = 0.095 Identities = 16/46 (34%), Positives = 22/46 (47%) Query: 650 CQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSP 695 C G+ L G + CQ N+QW P C+ S F P ++SP Sbjct: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511 Score = 38.9 bits (89), Expect = 0.095 Identities = 24/81 (29%), Positives = 33/81 (40%), Gaps = 10/81 (12%) Query: 135 SSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 S C P P G L T +G ++YSC G+IL G C+ N W P Sbjct: 2714 SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN----RKWSGASPR 2769 Query: 195 CRA------EDACGGTMRGSS 209 C A G+++GS+ Sbjct: 2770 CEAISCKKPNPVMNGSIKGSN 2790 Score = 38.9 bits (89), Expect = 0.095 Identities = 24/86 (27%), Positives = 37/86 (43%), Gaps = 5/86 (5%) Query: 111 FSLRLTSDFAVSAHG-FKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYI 169 F L S+ A G + + + +SCG+ + P + T + I YSC +GY+ Sbjct: 3036 FKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYV 3095 Query: 170 LDGHPQLTCIANSVNTASWDFPVPIC 195 + G L C V W P P+C Sbjct: 3096 IQGSSDLICTEKGV----WSQPYPVC 3117 Score = 38.5 bits (88), Expect = 0.12 Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 4/58 (6%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 C +P V G + G + +I Y+C G++L+G C+AN SW P C Sbjct: 2833 CSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLAN----GSWSGATPDC 2886 Score = 38.1 bits (87), Expect = 0.16 Identities = 21/57 (36%), Positives = 26/57 (45%), Gaps = 8/57 (14%) Query: 145 PKGVLYG----TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 PK +L G T G + YSC G+ L+G LTC+ T WD P C A Sbjct: 2501 PKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL----ETGDWDVDAPSCNA 2553 Score = 37.4 bits (85), Expect = 0.28 Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 2/59 (3%) Query: 2169 KQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFT--VGQTISFECFPGYTLIGNSALTCL 2225 ++G+ Q +L CP +P NG+ I N C PG+ L+G+S + CL Sbjct: 363 REGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCL 421 Score = 37.4 bits (85), Expect = 0.28 Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 7/80 (8%) Query: 446 CPDPGEPENGKRIGS--DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 CP +P++G S + +T +CDE Y L+G+ +TCQ ++ W P C Sbjct: 438 CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ----WDGPEPRC 493 Query: 504 KVKTCGSNLQGPSGTFTSPN 523 + C S Q P SP+ Sbjct: 494 VERHC-STFQMPKDVIISPH 512 Score = 37.0 bits (84), Expect = 0.36 Identities = 16/41 (39%), Positives = 21/41 (51%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTC 178 CG P G + G F+VG K+++ C GY L G TC Sbjct: 2264 CGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTC 2304 Score = 37.0 bits (84), Expect = 0.36 Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 10/80 (12%) Query: 134 QSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVP 193 ++ SC P G + G+ + + Y C GY+L+G + TC + +WD P Sbjct: 2771 EAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTC----QDDKNWDEDEP 2826 Query: 194 ICRAED------ACGGTMRG 207 IC D + G +RG Sbjct: 2827 ICIPVDCSSPPVSANGQVRG 2846 Score = 36.2 bits (82), Expect = 0.61 Identities = 20/65 (30%), Positives = 27/65 (41%), Gaps = 6/65 (9%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 C +P G + G + G I YSC G+ + GH TC + W +P C Sbjct: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTC-----EESGWSSSIPTCMP 2610 Query: 198 EDACG 202 D CG Sbjct: 2611 ID-CG 2614 Score = 35.4 bits (80), Expect = 1.0 Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 4/52 (7%) Query: 818 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSP 869 V C+EG+ + +G++ +TC G W G P+C F P VI+SP Sbjct: 464 VACDEGY-RLEGSDKLTC---QGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511 Score = 35.4 bits (80), Expect = 1.0 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 4/65 (6%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 SCG P G F G + Y C GY L G ++ C N SW+ P C Sbjct: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDN----GSWNGVSPSCL 1744 Query: 197 AEDAC 201 D C Sbjct: 1745 DVDEC 1749 Score = 35.4 bits (80), Expect = 1.0 Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 4/40 (10%) Query: 157 GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 G + YSC GY L+G + C N +W PVP+C+ Sbjct: 3318 GPNVVYSCNRGYSLEGPSEAHCTEN----GTWSHPVPLCK 3353 Score = 35.0 bits (79), Expect = 1.4 Identities = 20/59 (33%), Positives = 25/59 (42%), Gaps = 4/59 (6%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 +CG P G G F G I+Y C GY L G+ C++N SW P C Sbjct: 2948 NCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSN----GSWSGSSPSC 3002 Score = 35.0 bits (79), Expect = 1.4 Identities = 25/79 (31%), Positives = 32/79 (40%), Gaps = 6/79 (7%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 C P V G + GT FD G R C G+ L G ++TC A+ W P C Sbjct: 3007 CSTP-VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEAD----GQWSSGFPHCE- 3060 Query: 198 EDACGGTMRGSSGIISSPS 216 +CG + IS S Sbjct: 3061 HTSCGSLPMIPNAFISETS 3079 Score = 34.7 bits (78), Expect = 1.8 Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%) Query: 1300 EGFQLVYTSFELSHCEDPGIPQFGYKISD--QGHFAGSTIIYGCNPGYTLHGSSLLKCM 1356 EG++ + EL HC P+ GY I + HF + + C+PG+ L GSS++ C+ Sbjct: 364 EGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR-CHPGFDLVGSSIILCL 421 Score = 33.9 bits (76), Expect = 3.0 Identities = 32/105 (30%), Positives = 41/105 (39%), Gaps = 15/105 (14%) Query: 137 SCGNPGVPPKGVLYGTRFDVGD-KIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 SCG P G L T + + ++RY C GY G P C AN W P+ Sbjct: 2203 SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQAN----RHWHSESPLM 2258 Query: 196 RAEDACG-------GTMRGSSGIISS--PSFPNE-YHNNADCTWT 230 CG G M+G + + S F NE Y D +WT Sbjct: 2259 CVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWT 2303 Score = 33.5 bits (75), Expect = 4.0 Identities = 14/44 (31%), Positives = 21/44 (47%) Query: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN 181 CG P V+ G F + + Y+C GY L G + C+A+ Sbjct: 1963 CGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLAD 2006 Score = 33.1 bits (74), Expect = 5.2 Identities = 21/67 (31%), Positives = 28/67 (41%), Gaps = 5/67 (7%) Query: 444 NLCPDPGE-PENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502 N CP P PEN +F + V C E ++LQG ITC W+ Sbjct: 3355 NPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC----NPDETWTQTSAK 3410 Query: 503 CKVKTCG 509 C+ +CG Sbjct: 3411 CEKISCG 3417 Score = 32.7 bits (73), Expect = 6.8 Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 2/37 (5%) Query: 1335 STIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCI 1371 +T + C+ GY L GS L C + WD P P C+ Sbjct: 460 TTCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494 Score = 32.3 bits (72), Expect = 8.9 Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 6/53 (11%) Query: 163 SCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSP 215 +C GY L+G +LTC NS WD P P C E C T + +I SP Sbjct: 465 ACDEGYRLEGSDKLTCQGNS----QWDGPEPRC-VERHC-STFQMPKDVIISP 511 Score = 32.3 bits (72), Expect = 8.9 Identities = 26/104 (25%), Positives = 35/104 (33%), Gaps = 5/104 (4%) Query: 162 YSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEY 221 YSC TGY L G + C A+ + WD P C CG +I+ +F Sbjct: 1929 YSCDTGYSLQGPSIIECTASGI----WDRAPPACHLV-FCGEPPAIKDAVITGNNFTFRN 1983 Query: 222 HNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTI 265 C DTI + L + EPP + Sbjct: 1984 TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV 2027 >gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens] Length = 2489 Score = 410 bits (1053), Expect = e-113 Identities = 485/1932 (25%), Positives = 724/1932 (37%), Gaps = 356/1932 (18%) Query: 1658 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 R+SC +P + +NG + + GS + Y C GY L G S+ TCI+ D W+ P Sbjct: 101 RKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGD-TVIWDNETP 159 Query: 1717 SC-HAPCGSRSTGSEGTVLSPNYPKNYSVG----HNCVYSIAVPKEFVVFGQFVFFQTSL 1771 C PCG T + G +S N +N+ G + C K F + G+ + TS Sbjct: 160 ICDRIPCGLPPTITNGDFISTNR-ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218 Query: 1772 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKGFHFV 1826 D V ++ GP Q + + + + + +S + + F KG V Sbjct: 219 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 278 Query: 1827 Y-QAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAI 1876 QA+ + CS V +P +R + F+ G V + C PGY L G+ ++ Sbjct: 279 KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 338 Query: 1877 RCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGA 1935 RC W+ + PTC + C + G +L+ P + L EG Sbjct: 339 RC----TPQGDWSPAAPTCEVKSCDDFM----GQLLNGRVLFPVNLQLGAKVDFVCDEGF 390 Query: 1936 GIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISV 1995 ++ S+ +SL + S + V Sbjct: 391 QLKGSSASYCVLAGMESL-----------------------------------WNSSVPV 415 Query: 1996 SAAGFHLEYTAIGLDSCPEPQTPSSGIKIG---DRYMVGDVVSFQCD------QGYSLQG 2046 F CP P +G G + + G V++ CD + L G Sbjct: 416 CEQIF-----------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIG 464 Query: 2047 HSHITCMPGPVRR--WNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLP 2104 S I C P W+ P P C G++ P Sbjct: 465 ESTIRCTSDPQGNGVWSSPAPRC------------GILGHCQAPD--------------- 497 Query: 2105 IGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD 2164 H F T+T + T + P+ FS T +L + S Sbjct: 498 -----HFLFAKLKTQT-------NASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSP 545 Query: 2165 YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALT 2223 K+ +SC P NG V + D VG I++ C G+ LIG+S+ Sbjct: 546 KDVCKR-----------KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594 Query: 2224 C-LHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI 2281 C L G + +W+ P C+ + CG T NG S + + + R PG+G Sbjct: 595 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTY---RCNPGSGG 651 Query: 2282 YINFTVLQTEPIY-----DFITVWDGPDQ--------NSPQIGQFSGNTALESVYSTSNQ 2328 F ++ IY D + +W GP P + + S++S + Sbjct: 652 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV 711 Query: 2329 ILIKFHSDFTTSGFFVLSYHAYQ---------LRVCQPPPPVPNAEILTED-DEFEIGDI 2378 + + F G + A RVCQPPP V +AE D D F G Sbjct: 712 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 771 Query: 2379 IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSY 2438 + Y C PG+ L G A + C + A P C+V + + G +L P Sbjct: 772 VFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP------ 823 Query: 2439 PNLQMCA-WSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFN 2497 NLQ+ A ++G+ + G + VL + ++S+ Sbjct: 824 VNLQLGAKVDFVCDEGFQL-------------------KGSSASYCVLAGMESLWNSSVP 864 Query: 2498 ITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQL-----NSVV 2552 + +C +P P+G TG L V Sbjct: 865 VCEQ-------------------------IFCPSPPVIPNG---RHTGKPLEVFPFGKTV 896 Query: 2553 RWAC----DRG--FRLVGKSSAVCRKSSYGYHAWDAPVPACQAIS-CGIP--------KA 2597 + C DRG F L+G+S+ C G W +P P C + C P K Sbjct: 897 NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKT 956 Query: 2598 PTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSI 2657 TN +D+ +GT + Y C Y +T C + WS+ C +C + Sbjct: 957 QTN----ASDFPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKDV--CKRKSCKTP 1007 Query: 2658 NSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS-WRNERPYCQI 2716 + +G ++ + + +++ +SC G+ +G +S EC+ +G + W + P CQ Sbjct: 1008 PDPV--NGMVHVI--TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQR 1063 Query: 2717 ISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLG------FMLVGSAVRECLSS----G 2763 I CG PT NG+ I T YGS + C+ G F LVG C S+ G Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 1123 Query: 2764 LWSESETRCLAGHCGIPELIVNGQVIGEN---YGYRDTVVYQCNPGFRLIGSSVRICQQD 2820 +WS +C+ + P + NG ++ +N + + V ++C PGF + G CQ Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 1183 Query: 2821 HNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLMQGPTKAQCQA 2877 + W +LPSC V C P ++ RT + NF+ V +SC GY ++G +C Sbjct: 1184 NKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 1242 Query: 2878 NRQWSHPPPMCKVVNCSD-PGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2936 WS P C+V +C D G N + + N G V + C+ G+ L GSS Sbjct: 1243 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPV---NLQLGAKVDFVCDEGFQLKGSSASY 1299 Query: 2937 CQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG---EKYTFGSTVHYSCT------GK 2984 C G W+ +P C I C P V PN +G E + FG V+Y+C Sbjct: 1300 CVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTS 1359 Query: 2985 RSLLGQSSRTC----QLNGHWSGSQPHCSGDATGTCGDPGTPGH-------GSRQESNFR 3033 L+G+S+ C Q NG WS P C G G P H S+F Sbjct: 1360 FDLIGESTIRCTSDPQGNGVWSSPAPRC-----GILGHCQAPDHFLFAKLKTQTNASDFP 1414 Query: 3034 TKSTVRYACDTGYILHGSE-ERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT 3092 ++++Y C Y +G TCL N W+ + CK C P NG V I Sbjct: 1415 IGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQ 1472 Query: 3093 FSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDPGIPANG---LRYG 3146 S + YSC G+ L G S +C +G WS P C I CG P ANG Sbjct: 1473 VGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNR 1532 Query: 3147 DDYVVGQNVSYMCQPG----YTMELNGSRIRTCTIN----GTWSGVMPTCRAVTCPTPPQ 3198 +++ G V+Y C G EL G CT N G WSG P C TPP Sbjct: 1533 ENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 1592 Query: 3199 ISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3255 + NG L N F + + C PG+ + P + C W E+P C + C P Sbjct: 1593 VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-SRVCQPPP 1651 Query: 3256 IPAQGKR---EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSC 3312 G+ +F EV +SC + L G+++ C G WS +P C SC Sbjct: 1652 EILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC---AVKSC 1708 Query: 3313 EN-PGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PDLTWSGIQPECIP 3368 ++ G HG Q+G+ V F C +G L+GS+ C+ W+ P C Sbjct: 1709 DDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEH 1768 Query: 3369 HSCKQPE---TPAHANVVGMDLPSHGYTLIYTCQP------GFFLAGGTEHRVCRSD--- 3416 C P H D+P +G + YTC P F L G + R C SD Sbjct: 1769 IFCPNPPAILNGRHTGTPSGDIP-YGKEISYTCDPHPDRGMTFNLIGESTIR-CTSDPHG 1826 Query: 3417 -NTWTGKVPICE 3427 W+ P CE Sbjct: 1827 NGVWSSPAPRCE 1838 Score = 338 bits (866), Expect = 8e-92 Identities = 289/974 (29%), Positives = 406/974 (41%), Gaps = 103/974 (10%) Query: 2537 HGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK 2596 +G ++ QL + V + CD GF+L G S++ C + W++ VP C+ I C P Sbjct: 1267 NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME-SLWNSSVPVCEQIFCPSPP 1325 Query: 2597 APTNG---GILTTDYLVGTRVTYFCNDGY-RLSSKEL---TTAVCQSD----GTWSNHNK 2645 NG G + G V Y C+ R +S +L +T C SD G WS+ Sbjct: 1326 VIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS--P 1383 Query: 2646 TPRCVVVT-CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2704 PRC ++ C + + F+ + + N S + T + + C P Y+G P SI CL N Sbjct: 1384 APRCGILGHCQAPDHFLFAKLKTQ-TNASDFPIGTSLKYECRPEYYGR-PFSITCLDNLV 1441 Query: 2705 WSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG 2763 WS + + C+ SC P P NG + T GS ++C G L+G + EC+ SG Sbjct: 1442 WS--SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSG 1499 Query: 2764 L---WSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG------FRLIG 2811 WS C CG+P I NG I EN+ Y V Y+CN G F L+G Sbjct: 1500 NTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVG 1559 Query: 2812 SSVRICQQDHN----WSGQLPSCV-PVSCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIG 2864 C + + WSG P C+ P C P + I + + F+ N+VV F C G Sbjct: 1560 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1619 Query: 2865 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2924 ++M+GP + +CQA +W P C V P I S NF+ G VFY C Sbjct: 1620 FVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPS--HQDNFSPGQEVFYSCE 1677 Query: 2925 PGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCT 2982 PGY L G++ L C P G W P C + C +P VL G+ V + C Sbjct: 1678 PGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCD 1737 Query: 2983 GKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPG---TPGHGSRQESNFRTKS 3036 L G S C L G W+ S P C C +P H + Sbjct: 1738 EGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHI---FCPNPPAILNGRHTGTPSGDIPYGK 1794 Query: 3037 TVRYACD------TGYILHGSEERTCLA----NGSWTGRQPECK-AVQCGNPGTTAN--- 3082 + Y CD + L G C + NG W+ P C+ +V+ G+ T Sbjct: 1795 EISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPF 1854 Query: 3083 -GKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIP 3139 I+ F +S+ Y C GY S+ C N WS NC SCG P P Sbjct: 1855 ASPTIPINDFEFPVGTSLNYECRPGYFGKMFSI-SCLENLVWSSVEDNCRRKSCGPPPEP 1913 Query: 3140 ANGL-RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTING---TWSGVMPTCRAVTCPT 3195 NG+ D G V+Y C G+ L GS TC ++G TW P C ++C Sbjct: 1914 FNGMVHINTDTQFGSTVNYSCNEGF--RLIGSPSTTCLVSGNNVTWDKKAPICEIISCEP 1971 Query: 3196 PPQISNGRL---EGTNFDWGFSISYICSPG------YELSFPAVLTCVGN----GTWSGE 3242 PP ISNG T+F G ++Y C G +EL + C G WS Sbjct: 1972 PPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSP 2031 Query: 3243 VPQCL-PKFCGDPGIPAQGKREG-KSFIYQSE-VSFSCNFPFILVGSSTRICQADGTWSG 3299 P+C+ C P + + G +SF +E + F C F++VGS T CQ +G W Sbjct: 2032 PPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 2091 Query: 3300 SSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL 3357 PHC C+ P HG ++ F G V + C+ + L+G+ + C P Sbjct: 2092 KLPHC----SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQG 2147 Query: 3358 TWSGIQPECIPHSCKQ--PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAG-GTEHRVCR 3414 WS P C SC + P ++ ++L G + + C GF L G H V Sbjct: 2148 DWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNL-QLGAKVSFVCDEGFRLKGRSASHCVLA 2206 Query: 3415 SDNT-WTGKVPICE 3427 W VP+CE Sbjct: 2207 GMKALWNSSVPVCE 2220 Score = 334 bits (856), Expect = 1e-90 Identities = 296/1001 (29%), Positives = 414/1001 (41%), Gaps = 122/1001 (12%) Query: 2537 HGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK 2596 +G ++ QL + V + CD GF+L G S++ C + W++ VP C+ I C P Sbjct: 817 NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME-SLWNSSVPVCEQIFCPSPP 875 Query: 2597 APTNG---GILTTDYLVGTRVTYFCNDGY-RLSSKEL---TTAVCQSD----GTWSNHNK 2645 NG G + G V Y C+ R +S +L +T C SD G WS+ Sbjct: 876 VIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS--P 933 Query: 2646 TPRCVVVT-CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2704 PRC ++ C + + F+ + + N S + T + + C P Y+G P SI CL N Sbjct: 934 APRCGILGHCQAPDHFLFAKLKTQ-TNASDFPIGTSLKYECRPEYYGR-PFSITCLDNLV 991 Query: 2705 WSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG 2763 WS + + C+ SC P P NG + T GS ++C G L+G + EC+ SG Sbjct: 992 WS--SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSG 1049 Query: 2764 L---WSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG------FRLIG 2811 WS C CG+P I NG I EN+ Y V Y+CNPG F L+G Sbjct: 1050 NAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 1109 Query: 2812 SSVRICQQDHN----WSGQLPSCV-PVSCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIG 2864 C + + WSG P C+ P C P + I + + F+ N+VV F C G Sbjct: 1110 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1169 Query: 2865 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2924 ++M+GP + +CQA +W P C V C P +++R + + NF+ G VFY C Sbjct: 1170 FVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQR-DKDNFSPGQEVFYSCE 1227 Query: 2925 PGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCT 2982 PGY L G++ + C P G W P C + C + VL G+ V + C Sbjct: 1228 PGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCD 1287 Query: 2983 GKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG--HGSRQESNFRTKST 3037 L G S+ C L G W+ S P C + P P H + F Sbjct: 1288 EGFQLKGSSASYCVLAGMESLWNSSVPVC--EQIFCPSPPVIPNGRHTGKPLEVFPFGKA 1345 Query: 3038 VRYACD------TGYILHGSEERTCLA----NGSWTGRQPECKAV-QCGNPG-------- 3078 V Y CD T + L G C + NG W+ P C + C P Sbjct: 1346 VNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLK 1405 Query: 3079 TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGI 3138 T N F I +S+ Y C Y P C N WS C SC P Sbjct: 1406 TQTNASDFPI-----GTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPD 1459 Query: 3139 PANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCP 3194 P NG+ + D VG ++Y C G+ L G C ++G WS P C+ + C Sbjct: 1460 PVNGMVHVITDIQVGSRINYSCTTGH--RLIGHSSAECILSGNTAHWSTKPPICQRIPCG 1517 Query: 3195 TPPQISNGRLEGT---NFDWGFSISYICSPG------YELSFPAVLTCVGN----GTWSG 3241 PP I+NG T NF +G ++Y C+ G +EL + C N G WSG Sbjct: 1518 LPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSG 1577 Query: 3242 EVPQC-LPKFCGDP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT 3296 PQC +P C P GI R F V F C F++ G CQA Sbjct: 1578 PAPQCIIPNKCTPPNVENGILVSDNR--SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1635 Query: 3297 WSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL 3354 W P C C+ P HG + ++ F G V + C+ G+ L+G+ + C Sbjct: 1636 WEPELPSC----SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT 1691 Query: 3355 PDLTWSGIQPECIPHSCKQ--PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR- 3411 P WS P C SC + P H V+ G + + C GF L G + Sbjct: 1692 PQGDWSPEAPRCAVKSCDDFLGQLP-HGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC 1750 Query: 3412 -VCRSDNTWTGKVPICEAGSKILVKDPRPAL------GTPS 3445 + + W VP+CE I +P PA+ GTPS Sbjct: 1751 VLVGMRSLWNNSVPVCE---HIFCPNP-PAILNGRHTGTPS 1787 Score = 321 bits (823), Expect = 7e-87 Identities = 274/992 (27%), Positives = 410/992 (41%), Gaps = 124/992 (12%) Query: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 C TP P +G + T Q+ S + ++C G RL+G SSA C S H W P CQ Sbjct: 1454 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAH-WSTKPPICQ 1512 Query: 2589 AISCGIPKAPTNGGILTT---DYLVGTRVTYFCNDGYR-LSSKELT---TAVCQSD---- 2637 I CG+P NG ++T ++ G+ VTY CN G R EL + C S+ Sbjct: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572 Query: 2638 GTWSNHNKTPRCVV---VTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGP 2694 G WS P+C++ T P++ + IL N S + V F C PG+ GP Sbjct: 1573 GIWS--GPAPQCIIPNKCTPPNVENGILVSD-----NRSLFSLNEVVEFRCQPGFVMKGP 1625 Query: 2695 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT-------SYGSTAIFTCDL 2747 ++C W E P SC + PP G T S G ++C+ Sbjct: 1626 RRVKC--QALNKWEPELP-----SCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEP 1678 Query: 2748 GFMLVGSAVRECLSSGLWSESETRCLAGHCG--IPELIVNGQVIGENYGYRDTVVYQCNP 2805 G+ L G+A C G WS RC C + +L + N V + C+ Sbjct: 1679 GYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1738 Query: 2806 GFRLIGSSVRIC---QQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG---NGFNFNDVVTF 2859 GFRL GSSV C W+ +P C + C +P + + GR +G + +++ Sbjct: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1798 Query: 2860 SCN------IGYLMQGPTKAQC----QANRQWSHPPPMCKVV----NCSDPGIPANSKRE 2905 +C+ + + + G + +C N WS P P C++ +C P + Sbjct: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT 1858 Query: 2906 SKIEHGNFTYGTVVFYDCNPGYF--LFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPN 2963 I F GT + Y+C PGYF +F S C N W C CG P P N Sbjct: 1859 IPINDFEFPVGTSLNYECRPGYFGKMFSIS---CLENLVWSSVEDNCRRKSCGPPPEPFN 1915 Query: 2964 AVLSGEKYT-FGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDP 3019 ++ T FGSTV+YSC L+G S TC ++G+ W P C +C P Sbjct: 1916 GMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE---IISCEPP 1972 Query: 3020 GTPGHG---SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQ 3066 T +G S ++F + V Y C TG + L G C + G W+ Sbjct: 1973 PTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPP 2032 Query: 3067 PECKAV-QCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTANGTW 3121 P C + +C P R+ G T + + + C G+++ G QC NG W Sbjct: 2033 PRCISTNKCTAPEVE---NAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRW 2089 Query: 3122 SGTLPNCTIISCGDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTING 3179 LP+C+ + P I + L + D++ GQ V Y C+P Y +L G+ CT G Sbjct: 2090 GPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY--DLRGAASLHCTPQG 2147 Query: 3180 TWSGVMPTCRAVTCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG 3237 WS P C +C Q+ +GR L N G +S++C G+ L + CV G Sbjct: 2148 DWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAG 2207 Query: 3238 ---TWSGEVPQCLPKFCGDPGIPAQGKREGKSF---IYQSEVSFSCN------FPFILVG 3285 W+ VP C FC +P G+ G F Y E+S++C+ F L+G Sbjct: 2208 MKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIG 2267 Query: 3286 SSTRIC----QADGTWSGSSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGSVVQFHC 3339 S+ C Q +G WS +P C +C +P ++G + + G + + C Sbjct: 2268 ESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYIC 2327 Query: 3340 KKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLP-----SHGYTL 3394 G+LL G C WS + C +C P N + +L +G + Sbjct: 2328 DPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC---SFPLFMNGISKELEMKKVYHYGDYV 2384 Query: 3395 IYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3426 C+ G+ L G + C++D+ W + C Sbjct: 2385 TLKCEDGYTLEGSPWSQ-CQADDRWDPPLAKC 2415 Score = 299 bits (766), Expect = 3e-80 Identities = 244/822 (29%), Positives = 336/822 (40%), Gaps = 94/822 (11%) Query: 2679 TKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSY 2737 T + + C PGY G P SI CL N W+ +R C+ SC P P NG + + Sbjct: 67 TYLNYECRPGYSGR-PFSIICLKNSVWTGAKDR--CRRKSCRNPPDPVNGMVHVIKGIQF 123 Query: 2738 GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQVIG---E 2791 GS ++C G+ L+GS+ C+ SG +W C CG+P I NG I E Sbjct: 124 GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRE 183 Query: 2792 NYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PVSCGHPG- 2839 N+ Y V Y+CNPG F L+G C + + WSG P C+ P C P Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 243 Query: 2840 -SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2898 + I + + F+ N+VV F C G++M+GP + +CQA +W P C V C P Sbjct: 244 ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPD 302 Query: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH- 2957 +++R + + NF+ G VFY C PGY L G++ + C P G W P C + C Sbjct: 303 VLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361 Query: 2958 -PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDAT 3013 + VL G+ V + C L G S+ C L G W+ S P C + Sbjct: 362 MGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC--EQI 419 Query: 3014 GTCGDPGTPG--HGSRQESNFRTKSTVRYACD------TGYILHGSEERTCLA----NGS 3061 P P H + F TV Y CD T + L G C + NG Sbjct: 420 FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 479 Query: 3062 WTGRQPECKAV-QCGNPG--------TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSV 3112 W+ P C + C P T N F I +S+ Y C Y P Sbjct: 480 WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI-----GTSLKYECRPEY-YGRPFS 533 Query: 3113 RQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSR 3171 C N WS C SC P P NG+ + D VG ++Y C G+ L G Sbjct: 534 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGH--RLIGHS 591 Query: 3172 IRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGT---NFDWGFSISYICSPG--- 3222 C ++G WS P C+ + C PP I+NG T NF +G ++Y C+PG Sbjct: 592 SAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGG 651 Query: 3223 ---YELSFPAVLTCVGN----GTWSGEVPQC-LPKFCGDP----GIPAQGKREGKSFIYQ 3270 +EL + C N G WSG PQC +P C P GI R F Sbjct: 652 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNR--SLFSLN 709 Query: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFG 3328 V F C F++ G CQA W P C C+ P H +Q + Sbjct: 710 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC----SRVCQPPPDVLHAERTQRDKDN 765 Query: 3329 FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ-PETPAHANVVGMDL 3387 F G V + C+ G+ L+G+ + C P WS P C SC + V+ Sbjct: 766 FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN 825 Query: 3388 PSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICE 3427 G + + C GF L G + + ++ W VP+CE Sbjct: 826 LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 867 Score = 272 bits (695), Expect = 5e-72 Identities = 266/1003 (26%), Positives = 398/1003 (39%), Gaps = 129/1003 (12%) Query: 2529 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2584 C+ PE P + T + + + + C G+ G+ S +C K+S W Sbjct: 43 CNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTGAK 96 Query: 2585 PACQAISCGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT-WSN 2642 C+ SC P P NG + + G+++ Y C GYRL T + D W Sbjct: 97 DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWD- 155 Query: 2643 HNKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHG------LG 2693 N+TP C + C P+I +G + N ++ Y + V + C+PG G +G Sbjct: 156 -NETPICDRIPCGLPPTIT-----NGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 209 Query: 2694 PASIECLPNG--TWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGS---TAIFTCDLG 2748 SI C N W P C I + P NG + S S F C G Sbjct: 210 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 269 Query: 2749 FMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG---QVIGENYGYRDTVVYQCNP 2805 F++ G +C + W E E + C P +++ Q +N+ V Y C P Sbjct: 270 FVMKGPRRVKCQALNKW-EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEP 328 Query: 2806 GFRLIGSSVRICQQDHNWSGQLPSCVPVSC-GHPGSPIYGRT-SGNGFNFNDVVTFSCNI 2863 G+ L G++ C +WS P+C SC G + GR V F C+ Sbjct: 329 GYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDE 388 Query: 2864 GYLMQGPTKAQC---QANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVF 2920 G+ ++G + + C W+ P+C+ + C P + N + K F +G V Sbjct: 389 GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGK-PLEVFPFGKTVN 447 Query: 2921 YDCNP------GYFLFGSSVLIC----QPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK 2970 Y C+P + L G S + C Q NG W P P C ++ GH P + + + K Sbjct: 448 YTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAPDHFLFAKLK 505 Query: 2971 -------YTFGSTVHYSCTGKRSLLGQS-SRTCQLNGHWSGSQPHCSGDATGTCGDPGTP 3022 + G+++ Y C + G+ S TC N WS + C +C P P Sbjct: 506 TQTNASDFPIGTSLKYEC--RPEYYGRPFSITCLDNLVWSSPKDVCK---RKSCKTPPDP 560 Query: 3023 GHGS-RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS---WTGRQPECKAVQCGNPG 3078 +G ++ + S + Y+C TG+ L G C+ +G+ W+ + P C+ + CG P Sbjct: 561 VNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPP 620 Query: 3079 TTANGKVFRIDGTTF--SSSVIYSCMEG------YILSGPSVRQCTAN----GTWSGTLP 3126 T ANG + F S V Y C G + L G CT+N G WSG P Sbjct: 621 TIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAP 680 Query: 3127 NCTIISCGDPGIPANGLRYGDD---YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSG 3183 C I + P NG+ D+ + + + V + CQPG+ M+ G R C W Sbjct: 681 QCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMK--GPRRVKCQALNKWEP 738 Query: 3184 VMPTCRAVTCPTPPQISNG---RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3240 +P+C V C PP + + + + NF G + Y C PGY+L A + C G WS Sbjct: 739 ELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797 Query: 3241 GEVPQCLPKFCGDPGIPAQGKREGKSFIYQ------SEVSFSCNFPFILVGSSTRICQAD 3294 P C K C D G+ ++ ++V F C+ F L GSS C Sbjct: 798 PAAPTCEVKSCDD----FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 853 Query: 3295 G---TWSGSSPHCIEPTQTSCENPGVPRHGSQNN------TFGFQVGSVVQFHCKKGHL- 3344 G W+ S P C Q C +P V +G FG V H +G Sbjct: 854 GMESLWNSSVPVC---EQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSF 910 Query: 3345 -LQGSTTRTCLPDL----TWSGIQPEC-IPHSCKQPETPAHANVV----GMDLPSHGYTL 3394 L G +T C D WS P C I C+ P+ A + D P G +L Sbjct: 911 DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI-GTSL 969 Query: 3395 IYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3437 Y C+P ++ G C + W+ +C+ S DP Sbjct: 970 KYECRPEYY--GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDP 1010 Score = 209 bits (533), Expect = 3e-53 Identities = 241/937 (25%), Positives = 355/937 (37%), Gaps = 198/937 (21%) Query: 2355 CQPPPPVPNAEIL-TEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413 C PP + N + + T + F G ++ Y+C G R + ++ G P Sbjct: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLG----------SRGRKVFELVGEP---S 1562 Query: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK--EFDV 2471 + C +N+ D G+ P PN C +VE G ++ F + EF Sbjct: 1563 IYCTSND---DQVGIWSGPAPQCIIPN--KCT-PPNVENGILVSDNRSLFSLNEVVEFRC 1616 Query: 2472 LQ--VYDGP--------NIQSPVLISLS-----------GDYSSAFNIT-SNGHEVFLQW 2509 V GP N P L S S G+++ + S G EVF + Sbjct: 1617 QPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVF--Y 1674 Query: 2510 SADHGNNKKGFRIRYIAFYCS-----TPESP--------------PHGYIISQTGGQLNS 2550 S + G + +G + +C+ +PE+P PHG ++ QL + Sbjct: 1675 SCEPGYDLRGAA----SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGA 1730 Query: 2551 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNG---GILTTD 2607 V + CD GFRL G S + C W+ VP C+ I C P A NG G + D Sbjct: 1731 KVSFVCDEGFRLKGSSVSHCVLVGMR-SLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGD 1789 Query: 2608 YLVGTRVTYFCND----GYRLSSKELTTAVCQSD----GTWSN------------HNKTP 2647 G ++Y C+ G + +T C SD G WS+ H KTP Sbjct: 1790 IPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTP 1849 Query: 2648 RCVVVTCPSI--NSF------------------------ILEHGRWRIV----------- 2670 P+I N F LE+ W V Sbjct: 1850 EQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGP 1909 Query: 2671 -----NGSHY-----EYKTKVVFSCDPGYHGLGPASIECLPNGT-WSWRNERPYCQIISC 2719 NG + ++ + V +SC+ G+ +G S CL +G +W + P C+IISC Sbjct: 1910 PPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISC 1969 Query: 2720 GELPTPPNGNKIGT-QTSY--GSTAIFTCDLG------FMLVGSAVRECLSS----GLWS 2766 PT NG+ +TS+ G+ + C G F LVG C S G+WS Sbjct: 1970 EPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWS 2029 Query: 2767 ESETRCLAGH-CGIPELIVNGQVIGEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHNW 2823 RC++ + C PE+ +V G + + + ++C PGF ++GS CQ + W Sbjct: 2030 SPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRW 2089 Query: 2824 SGQLPSCVPVSCGHPGSPIYGR---TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ 2880 +LP C V C P ++G + + F+ V +SC Y ++G C Sbjct: 2090 GPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD 2148 Query: 2881 WSHPPPMCKVVNCSDPGIPANSKRESKIEHG------NFTYGTVVFYDCNPGYFLFGSSV 2934 WS P C V +C D ++ HG N G V + C+ G+ L G S Sbjct: 2149 WSPEAPRCTVKSCDD--------FLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSA 2200 Query: 2935 LICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSGEKY---TFGSTVHYSCTGKR--- 2985 C G W+ +P C I C +P N +G + +G + Y+C Sbjct: 2201 SHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRG 2260 Query: 2986 ---SLLGQSSRTC----QLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SRQESNFRTK 3035 +L+G+SS C Q NG WS P C C P +G S + Sbjct: 2261 MTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPG 2320 Query: 3036 STVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT--- 3092 T+ Y CD GY+L G C G W+ CK V C P NG ++ Sbjct: 2321 MTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFP-LFMNGISKELEMKKVYH 2379 Query: 3093 FSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129 + V C +GY L G QC A+ W L CT Sbjct: 2380 YGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCT 2416 Score = 132 bits (332), Expect = 6e-30 Identities = 305/1388 (21%), Positives = 470/1388 (33%), Gaps = 279/1388 (20%) Query: 1484 VATACRDPGVPMNGTRNGDGREP---GDTVVFQCDPGYELQGEERITCIQVENRYFWQPS 1540 + C P V NG D R + V F+C PG+ ++G R+ C Q N+ W+P Sbjct: 1134 IPNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNK--WEPE 1189 Query: 1541 PP----VCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIE 1596 P VC P P+ H RD D + + + +S E Sbjct: 1190 LPSCSRVCQPP--------------PDVLHAERTQRDKD-NFSPGQE-------VFYSCE 1227 Query: 1597 PNYDFL------------YIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSD--- 1641 P YD + P F L R+ N + L + D Sbjct: 1228 PGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN-LQLGAKVDFVC 1286 Query: 1642 --------GSVSY---TGFHLEYKAKL----RESCFDPGNIMNGTRLGMD---YKLGSTV 1683 S SY G + + + + C P I NG G + G V Sbjct: 1287 DEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAV 1346 Query: 1684 TYYCD------AGYVLQGYSTLTCIMGDDGRPGWNRALPSC------HAPCGSRSTGSEG 1731 Y CD + L G ST+ C G W+ P C AP + Sbjct: 1347 NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKT 1406 Query: 1732 TVLSPNYPKNYSVGHNCVYSI-AVPKEFVVFGQFVFFQTSLHDVVE---VYDGPTQQSSL 1787 + ++P S+ + C P V+ +S DV + P + + Sbjct: 1407 QTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVW--SSPKDVCKRKSCKTPPDPVNGM 1464 Query: 1788 LSSLSGSHSGESLPLS--SGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPR 1845 + ++ G + S +G+++ ++ ++ H+ + P C P Sbjct: 1465 VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKP-PICQRIPCGLPPTIA 1523 Query: 1846 FGRRIGNE---FAVGSSVLFDCNPG------YILHGSIAIRCETVPNSLAQWNDSLPTCI 1896 G I F GS V + CN G + L G +I C + + + W+ P CI Sbjct: 1524 NGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1583 Query: 1897 VP--C------GGILTKRKGTILS----------PGYPEPYDNNLNCV----WKITVPEG 1934 +P C GIL ++ S PG+ + C W+ +P Sbjct: 1584 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1643 Query: 1935 AGI-QVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDI 1993 + + Q EH D + G YS L + S L+ Q D Sbjct: 1644 SRVCQPPPEILHGEHTPSHQDNFSPGQEVF-----YSCEPGYDLRGAAS--LHCTPQGDW 1696 Query: 1994 SVSAAGFHLEYTAIGLDSCPE--PQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHIT 2051 S A + SC + Q P + +G VSF CD+G+ L+G S Sbjct: 1697 SPEAP-------RCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSH 1749 Query: 2052 CMPGPVRR-WNYPIPICL-AQCGGAMSDFSGVILSPGFP-GNYPSSLDCTWTINLPIGFG 2108 C+ +R WN +P+C C + +G G P G+ P + ++T + G Sbjct: 1750 CVLVGMRSLWNNSVPVCEHIFCPNPPAILNG--RHTGTPSGDIPYGKEISYTCDPHPDRG 1807 Query: 2109 VHLQFVNFSTETIHD---------------YLEVRSGSSETSTVIGRLSGPQIPSSLFST 2153 + + ST L VR+G +T + P IP + F Sbjct: 1808 MTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFP-FASPTIPINDFEF 1866 Query: 2154 THETSLYFHSDYSQNKQGFHI----------VYQAYQLQSC-PDPRPFRNGFVIGNDFTV 2202 TSL + + F I V + +SC P P PF I D Sbjct: 1867 PVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQF 1926 Query: 2203 GQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYP 2260 G T+++ C G+ LIG+ + TCL G + W+ P CE + C T NG YS Sbjct: 1927 GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRT 1986 Query: 2261 DEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY-----DFITVWDGPDQNSPQIGQFSG 2315 + + P G + F ++ IY D + VW P + + Sbjct: 1987 SFHNGTVVTYQCHTGPDGEQL---FELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTA 2043 Query: 2316 NTALESVYSTSNQI------LIKFHSDFTTSGFFVLSYHAYQL--------------RVC 2355 ++ N+ +I+F GF ++ H Q RVC Sbjct: 2044 PEVENAIRVPGNRSFFTLTEIIRFRCQ---PGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100 Query: 2356 QPPPPVPNAE-ILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAP--PVC 2412 QPPP + + E L+ D F G + Y C P + L G A L C Q D +P P C Sbjct: 2101 QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC----TPQGDWSPEAPRC 2156 Query: 2413 QVLCPANELRLDSTGVILSPGYPDSYPNLQMCA-WSISVEKGYNITMFVEFFQTEKEFDV 2471 V + L G +L P NLQ+ A S ++G+ + Sbjct: 2157 TVKSCDDFLGQLPHGRVLLP------LNLQLGAKVSFVCDEGFRL--------------- 2195 Query: 2472 LQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCST 2531 G + VL + ++S+ + +C Sbjct: 2196 ----KGRSASHCVLAGMKALWNSSVPVCEQ-------------------------IFCPN 2226 Query: 2532 PESPPHGYIISQTGGQL--NSVVRWAC----DRG--FRLVGKSSAVCRKSSYGYHAWDAP 2583 P + +G G + + +AC DRG F L+G+SS C G W +P Sbjct: 2227 PPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSP 2286 Query: 2584 VPACQ---AISCGIPKAPTNG---GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSD 2637 P C+ +C P NG G + YL G ++Y C+ GY L K C Sbjct: 2287 APRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGF--IFCTDQ 2344 Query: 2638 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI 2697 G WS + + V + P + I + + V Y Y V C+ GY G Sbjct: 2345 GIWSQLDHYCKEVNCSFPLFMNGISKELEMKKV----YHYGDYVTLKCEDGYTLEGSPWS 2400 Query: 2698 ECLPNGTW 2705 +C + W Sbjct: 2401 QCQADDRW 2408 Score = 80.1 bits (196), Expect = 4e-14 Identities = 93/409 (22%), Positives = 153/409 (37%), Gaps = 99/409 (24%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C P EP NG I +D GSTV +SC+E + L G+ S TC ++ W P+C+ Sbjct: 1907 CGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCL-VSGNNVTWDKKAPICE 1965 Query: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 + +C P T ++ +F Y +N T+ + V+ Y T Sbjct: 1966 IISCE-----PPPTISNGDF---YSNNR------TSFHNGTVVT-----------YQCHT 2000 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 DG ++ + + S D + SS + T+ K E+E + Sbjct: 2001 GPDGEQLFELVGERSIYCTS-KDDQVGVWSSPPPRCISTN--------KCTAPEVEN-AI 2050 Query: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSN 684 PG + F+ +++RF CQ GF ++G ++ CQ N +W +P C S Sbjct: 2051 RVPGNRSF-------FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC-----SR 2098 Query: 685 FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-S 742 P +L ++ + +N + PG + S +DL GD S Sbjct: 2099 VCQPPPEILHGEHTLSHQDNFS--------PGQEVFYSCEPSYDLRGAASLHCTPQGDWS 2150 Query: 743 PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPIN 802 PE+P + + L +L L Sbjct: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLPL--------------------------------- 2177 Query: 803 ARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851 N QLG+ +S +C+EGF + +G C+L K +W+ +P C Sbjct: 2178 ------NLQLGAKVSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVC 2219 Score = 72.4 bits (176), Expect = 8e-12 Identities = 225/1043 (21%), Positives = 355/1043 (34%), Gaps = 219/1043 (20%) Query: 808 DNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPKCGAP--CGGHF 859 +NF GS ++ C G + G +I C D +V +WSG P+C P C Sbjct: 183 ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP- 241 Query: 860 SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQTELNYDVLEVH 912 + +G+++S + SLN +PG +K +++ EL Sbjct: 242 NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298 Query: 913 DGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 970 P++L + Q +F S Y L + R + T SC Sbjct: 299 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 358 Query: 971 LD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 1025 D G ++GR + + +G+ V F CD G++L C W+ +P C+ Sbjct: 359 DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ 418 Query: 1026 L-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1083 + C P+G G P E +P +T D +G F+ LI Sbjct: 419 IFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD-------------LI 463 Query: 1084 TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SDF----SISYE- 1128 E+ + G P G+ G+ +A F+ SDF S+ YE Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523 Query: 1129 -------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNFGIGDTLTFSCS 1169 F+IT + NL + C+ P P G + + +G + +SC+ Sbjct: 524 RPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCT 582 Query: 1170 SGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHE- 1226 +G+RL G S C L G WS P C CG T G +S N EN H Sbjct: 583 TGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNR----ENFHYG 638 Query: 1227 CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHLLGAFTGASMRG 1277 + + + G G + F L + D + I+ G + T ++ Sbjct: 639 SVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 695 Query: 1278 LTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE-----DPGIPQ 1321 L S + L+ +EF +G + V EL C P + Sbjct: 696 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 755 Query: 1322 FGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKG 1380 D+ +F+ G + Y C PGY L G++ ++C + W P+C + F G Sbjct: 756 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMG 813 Query: 1381 E-SSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDIL----RVWDGP 1435 + +GR+L FP + L D G F + AS+ +L +W+ Sbjct: 814 QLLNGRVL-----FPVNLQLGAKVDFVCDEG------FQLKGSSASYCVLAGMESLWNSS 862 Query: 1436 PENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495 + S +IP G H+ + F Sbjct: 863 VPVCEQIFCPSPPVIPNGRHTGKPLEVFPF------------------------------ 892 Query: 1496 NGTRNGDGREPGDTVVFQCDP------GYELQGEERITCI-QVENRYFWQPSPPVCIAPC 1548 G TV + CDP ++L GE I C + W P C Sbjct: 893 -----------GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC---- 937 Query: 1549 GGNLTGSSGFILSPN---FPHPYPHSRDCDWTITVNADYVISLAFIS--FSIEPNYDFLY 1603 G G +P+ F + D+ I + Y + FSI + ++ Sbjct: 938 -----GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVW 992 Query: 1604 -----------IYDGPDSNSPLIGSFQDSKLPERIESSSNTMH-LAFRSDGSVSYTGFHL 1651 PD + ++ D ++ RI S T H L S +G Sbjct: 993 SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAA 1052 Query: 1652 EYKAK----LRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYST 1698 + K R C P I NG + ++ GS VTY C+ G + L G + Sbjct: 1053 HWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 1112 Query: 1699 LTCIMGDDGRPGWNRALPSCHAP 1721 + C DD W+ P C P Sbjct: 1113 IYCTSNDDQVGIWSGPAPQCIIP 1135 Score = 70.9 bits (172), Expect = 2e-11 Identities = 196/861 (22%), Positives = 310/861 (36%), Gaps = 172/861 (19%) Query: 654 FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 693 F+LIGE +I C Q N WS+ P C +F L T P+GT L Sbjct: 460 FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 519 Query: 694 SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 749 + PE YG ++ C+ ++ S D K +P P+ G Sbjct: 520 KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 564 Query: 750 --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 800 T +V S + + H L A+ +SG + + P G+P Sbjct: 565 VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPC-GLPPTIA 623 Query: 801 ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 850 I+ R +NF GS ++ C G + G +I C D +V +WSG P+ Sbjct: 624 NGDFISTNR--ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681 Query: 851 CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQ 901 C P C + +G+++S + SLN +PG +K +++ Sbjct: 682 CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 737 Query: 902 TELNYDVLEVHDGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 959 EL P++L + Q +F S Y L + R Sbjct: 738 PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797 Query: 960 YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNH 1014 + T SC D G ++GR + + +G+ V F CD G++L C Sbjct: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES 857 Query: 1015 WWSHPLPTCDAL-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTF 1072 W+ +P C+ + C P+G G P E +P +T D +G F+ Sbjct: 858 LWNSSVPVCEQIFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD---- 911 Query: 1073 HLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SD 1122 LI E+ + G P G+ G+ +A F+ SD Sbjct: 912 ---------LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD 962 Query: 1123 F----SISYE--------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNF 1158 F S+ YE F+IT + NL + C+ P P G + + Sbjct: 963 FPIGTSLKYECRPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDI 1021 Query: 1159 GIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPN 1216 +G + +SC++G+RL G S C L G WS P C CG T G +S N Sbjct: 1022 QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN 1081 Query: 1217 YPLNYENNHE-CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHL 1266 EN H + + + G G + F L + D + I+ G + Sbjct: 1082 R----ENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 1134 Query: 1267 LGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE 1315 T ++ L S + L+ +EF +G + V EL C Sbjct: 1135 PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS 1194 Query: 1316 -----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPS 1369 P + D+ +F+ G + Y C PGY L G++ ++C + W P+ Sbjct: 1195 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPT 1252 Query: 1370 CIAECGGRFKGE-SSGRILSP 1389 C + F G+ +GR+L P Sbjct: 1253 CEVKSCDDFMGQLLNGRVLFP 1273 Score = 69.7 bits (169), Expect = 5e-11 Identities = 134/603 (22%), Positives = 207/603 (34%), Gaps = 149/603 (24%) Query: 640 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 699 FS +V+ F CQ GF + G + + CQ N+W +P C S P +L ++ Sbjct: 1606 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPEILHGEHTP 1660 Query: 700 GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 757 + +N + PG + S +DL GD SPE+P Sbjct: 1661 SHQDNFS--------PGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAP----------- 1701 Query: 758 SHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSIS 817 R ++ G+ +P F N QLG+ +S Sbjct: 1702 ----------RCAVKSCDDFLGQ------------------LPHGRVLFPLNLQLGAKVS 1733 Query: 818 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC------GAPC---GGHFSAPSGVILS 868 +C+EGF + +G+ C+L+ + +W+ +P C P G H PSG I Sbjct: 1734 FVCDEGF-RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI-- 1790 Query: 869 PGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSP-----LLG 923 P + S C +P +TF + H SP L Sbjct: 1791 ---PYGKEISYTC------DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSV 1841 Query: 924 SYNGTQVP-QFLFSS-----SNFIYLLFTTDNSRSNNGF-----------KIHYESVTVN 966 + P QF F+S ++F + + T+ N G+ + + SV N Sbjct: 1842 RAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDN 1901 Query: 967 --TYSCLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPL 1020 SC P P +G D GSTV++SC+ G+RL C N W Sbjct: 1902 CRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1961 Query: 1021 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1080 P C+ + P TI + +FY N+ +G V + HT + + Sbjct: 1962 PICEIIS----CEPPPTISN---GDFYSNN-----RTSFHNGTVVTYQCHT-GPDGEQLF 2008 Query: 1081 LLITENGSFTQPLARLTG--SDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138 L+ E + G S PP R IS + Sbjct: 2009 ELVGERSIYCTSKDDQVGVWSSPPP--------------RCISTNKCT------------ 2042 Query: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 P + I G+R F + + + F C G+ + G+ + C GR W LP C Sbjct: 2043 -APEVENAIRVPGNRSFFT--LTEIIRFRCQPGFVMVGSHTVQCQTNGR--WGPKLPHCS 2097 Query: 1199 AEC 1201 C Sbjct: 2098 RVC 2100 Score = 65.9 bits (159), Expect = 7e-10 Identities = 203/866 (23%), Positives = 304/866 (35%), Gaps = 179/866 (20%) Query: 654 FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 693 F+LIGE +I C Q N WS+ P C +F L T P+GT L Sbjct: 1360 FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 1419 Query: 694 SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 749 + PE YG ++ C+ ++ S D K +P P+ G Sbjct: 1420 KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 1464 Query: 750 --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 800 T +V S + + H L A+ +SG + + P G+P Sbjct: 1465 VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPC-GLPPTIA 1523 Query: 801 ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 850 I+ R +NF GS ++ C G + G +I C D +V +WSG P+ Sbjct: 1524 NGDFISTNR--ENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1581 Query: 851 CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDV 908 C P C + +G+++S + SLN +PG +K LN Sbjct: 1582 CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 1637 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGF-KIHY------- 960 E+ + P +G P + S + ++ + G +H Sbjct: 1638 PELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWS 1697 Query: 961 -ESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 1014 E+ SC D G HGR + + +G+ VSF CD G+RL S +L Sbjct: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS 1757 Query: 1015 WWSHPLPTCD--------ALCGGDVRG-PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1065 W++ +P C+ A+ G G PSG I P ++T D +G+ Sbjct: 1758 LWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI---------PYGKEISYTCDPHPDRGM 1808 Query: 1066 QFNF---HTFHL-EDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFIS 1121 FN T D H NG ++ P R S F + I+ Sbjct: 1809 TFNLIGESTIRCTSDPHG------NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPIN 1862 Query: 1122 DF------SISYEG----FNITFSEYNLE--------------PCEDPGIPQYGS-RIGF 1156 DF S++YE F FS LE C P P G I Sbjct: 1863 DFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINT 1922 Query: 1157 NFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-VAECGASATNNEGILLS 1214 + G T+ +SC+ G+RL G+ CL G V W P C + C T + G S Sbjct: 1923 DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYS 1982 Query: 1215 PNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGAS 1274 N ++ N Y Q G + F L G+ KD +G ++ Sbjct: 1983 -NNRTSFHNGTVVTY--QCHTGPD---GEQLFELV-GERSIYCTSKDDQ---VGVWSSPP 2032 Query: 1275 MRGL-----TLSSTSNQLWLEFNSDTEGTDE--------GFQLVYTSF-----------E 1310 R + T N + + N E GF +V + + Sbjct: 2033 PRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPK 2092 Query: 1311 LSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWD 1364 L HC P I + +S Q +F+ G + Y C P Y L G++ L C + W Sbjct: 2093 LPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCT--PQGDWS 2150 Query: 1365 YPLPSCIAECGGRFKGE-SSGRILSP 1389 P C + F G+ GR+L P Sbjct: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLP 2176 Score = 65.9 bits (159), Expect = 7e-10 Identities = 198/976 (20%), Positives = 330/976 (33%), Gaps = 193/976 (19%) Query: 1334 GSTIIYGCNPGYTLHGSSLLKC-MTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYP 1392 GS I Y C G+ L G S +C ++G W P C G ++G +S Sbjct: 1474 GSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 1533 Query: 1393 -FPYDN--NLRCMWMIEVDPGNIVSLQFLAFDT--------EASHDILRVWDGPPENDML 1441 F Y + RC N+ S F+ ++ D + +W GP ++ Sbjct: 1534 NFHYGSVVTYRC---------NLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 1584 Query: 1442 LKEISGSLIPEGIHSTLN--IVTIQFDTDF-----YISKSGFAIQFSS---------SVA 1485 + + + GI + N + ++ +F ++ K ++ + S + Sbjct: 1585 PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS 1644 Query: 1486 TACRDPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPP 1542 C+ P ++G + D PG V + C+PGY+L+G + C + W P P Sbjct: 1645 RVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAP 1701 Query: 1543 VCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFL 1602 C + G PH R +N ++F+ Sbjct: 1702 RCAVKSCDDFLGQ------------LPHGR---VLFPLNLQLGAKVSFVC---------- 1736 Query: 1603 YIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCF 1662 D L GS S S+ + + RS + S + E F Sbjct: 1737 ------DEGFRLKGS-----------SVSHCVLVGMRSLWNNS---------VPVCEHIF 1770 Query: 1663 DPG--NIMNGTRLGM---DYKLGSTVTYYCD------AGYVLQGYSTLTCIMGDDGRPGW 1711 P I+NG G D G ++Y CD + L G ST+ C G W Sbjct: 1771 CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVW 1830 Query: 1712 NRALPSCH--APCGSRSTGSEGTVLSPNYPKN---YSVGHNCVYSIAVPKEFVVFGQFVF 1766 + P C G T + SP P N + VG + Y FG+ +F Sbjct: 1831 SSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPG----YFGK-MF 1885 Query: 1767 FQTSLHDVV--EVYDG---------PTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSV 1815 + L ++V V D P + ++ + + G ++ S + + Sbjct: 1886 SISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS 1945 Query: 1816 GPITAKGFHFVY-QAVPRTSSTQCSSVPEPRFGRRIGN---EFAVGSSVLFDCNPG---- 1867 G + + + P C P G N F G+ V + C+ G Sbjct: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 2005 Query: 1868 --YILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNC 1925 + L G +I C + + + W+ P CI + + I PG + L Sbjct: 2006 QLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFF--TLTE 2063 Query: 1926 VWKITVPEG-AGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLN-STSN 1983 + + G + V T W + P + T+ H N S Sbjct: 2064 IIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQ 2123 Query: 1984 NLYLNFQSDISV-SAAGFHL--------EYTAIGLDSCPE--PQTPSSGIKIGDRYMVGD 2032 ++ + + + AA H E + SC + Q P + + +G Sbjct: 2124 EVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGA 2183 Query: 2033 VVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNY 2091 VSF CD+G+ L+G S C + G WN +P+C F N Sbjct: 2184 KVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVC----------------EQIFCPNP 2227 Query: 2092 PSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLF 2151 P+ L+ T P G + + ++++ +T D T +IG SS+ Sbjct: 2228 PAILNGRHT-GTPFGDIPYGKEISYACDTHPD-------RGMTFNLIGE-------SSIR 2272 Query: 2152 STTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTV---GQTISF 2208 T+ + +S + A +CP P +NG IG ++ G TIS+ Sbjct: 2273 CTSDPQG---NGVWSSPAPRCELSVPA----ACPHPPKIQNGHYIGGHVSLYLPGMTISY 2325 Query: 2209 ECFPGYTLIGNSALTC 2224 C PGY L+G + C Sbjct: 2326 ICDPGYLLVGKGFIFC 2341 Score = 63.9 bits (154), Expect = 3e-09 Identities = 107/455 (23%), Positives = 163/455 (35%), Gaps = 100/455 (21%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C +P +P NG + GS +++SC + Y L G+ S TC I+ W + P+C Sbjct: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCI-ISGDTVIWDNETPICD 162 Query: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 C G T T+ +F ++TN+ NF + + Y Sbjct: 163 RIPC-----GLPPTITNGDF----------------ISTNRE---NFH-YGSVVTY-RCN 196 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 G GG R V + L G P + + + D+ VG + + I C Sbjct: 197 PGSGG-----RKVFE-LVGE--PSIYCTSN---------DDQVG-IWSGPAPQCIIPNKC 238 Query: 625 GDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 681 P GI D FS +V+ F CQ GF + G + + CQ N+W +P C Sbjct: 239 TPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---- 293 Query: 682 LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDG 740 S P VL + + +N + PG + S +DL G Sbjct: 294 -SRVCQPPPDVLHAERTQRDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQG 344 Query: 741 D-SPESPILGTFTGAEVPSHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFG 790 D SP +P + + L N +L +++F D +G + +Y Sbjct: 345 DWSPAAPTCEVKSCDDFMGQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 403 Query: 791 HNE--------------CPDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQ 828 E CP P + N R G + F G +++ C+ Sbjct: 404 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463 Query: 829 GTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAP 862 G TI C G +WS P+CG GH AP Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAP 496 Score = 62.8 bits (151), Expect = 6e-09 Identities = 137/619 (22%), Positives = 201/619 (32%), Gaps = 134/619 (21%) Query: 648 FECQFGFELIGEKSIVCQ---ENNQWSANIPIC--IFPCLSNFTAPMGTVLSPD---YPE 699 F C GF+L G + C + W++++P+C IF C S P G +P Sbjct: 384 FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF-CPSPPVIPNGRHTGKPLEVFPF 442 Query: 700 GYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD---SPESPILGTFTGAEV 756 G N C DP SF D ES + G+ S +P G + Sbjct: 443 GKTVNYTC------DPHPDRGTSF-DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495 Query: 757 PSHL--------TSNSHI---LRLEFQADHSMSGRGFNITY----------NTFGHNECP 795 P H T+ S L+++ GR F+IT + C Sbjct: 496 PDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCK 555 Query: 796 DPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA- 853 P P+N + Q+GS I+ C G + G + CIL WS P C Sbjct: 556 TPPDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNAAHWSTKPPICQRI 614 Query: 854 PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDV 908 PCG + +G +S ++ S+ PG + FE N D Sbjct: 615 PCGLPPTIANGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESV 963 + + GP + V L S + ++ L R GF + + Sbjct: 672 VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731 Query: 964 TVNTYS---------CLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCE 1011 +N + C P +H R D FS G V +SC+ GY L + C Sbjct: 732 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 791 Query: 1012 KNHWWSHPLPTCDALCGGDVRGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF 1069 WS PTC+ D G +G +L +P +L VD +G Q Sbjct: 792 PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ--- 841 Query: 1070 HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG 1129 L GS + AG+ + + + Sbjct: 842 --------------------------LKGSSASYCVLAGMESLWNSSVPVCEQIF----- 870 Query: 1130 FNITFSEYNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEI 1180 C P + G G F G T+ ++C + + L G S I Sbjct: 871 ------------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918 Query: 1181 ICLGG--GRRVWSAPLPRC 1197 C G VWS+P PRC Sbjct: 919 RCTSDPQGNGVWSSPAPRC 937 Score = 60.8 bits (146), Expect = 2e-08 Identities = 143/626 (22%), Positives = 213/626 (34%), Gaps = 125/626 (19%) Query: 137 SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 SC P P G+++ T VG +I YSC TG+ L GH CI S N A W PIC Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNAAHWSTKPPIC 611 Query: 196 RAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIF-----TDFQMEE 250 + CG ++G S + N +H + T+ PG +F Sbjct: 612 Q-RIPCGLPPTIANGDFISTNREN-FHYGSVVTYR--CNPGSGGRKVFELVGEPSIYCTS 667 Query: 251 KYDYLEIEGSEPPTIWLSGMNIPPP------IISNKNWLRLHFVTDSNHRYRGFSAPYQG 304 D + I P + PP + N++ L+ V + F Sbjct: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE-------FRCQPGF 720 Query: 305 SSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVT----- 359 L + V P DV + T S Q V + Sbjct: 721 VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 780 Query: 360 SLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFK-SRG 418 LR + T + SP A T + Q+ + L V ++ +DF G Sbjct: 781 DLRGAASMRCTPQGDWSP-AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEG 839 Query: 419 FKLFPGKDNSNKFSILNEGGIKTASN---------LCPDPGEPENGKRIGSD---FSLGS 466 F+L K +S + +L G+++ N CP P NG+ G F G Sbjct: 840 FQL---KGSSASYCVL--AGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGK 894 Query: 467 TVQFSCD------EDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFT 520 TV ++CD + L G +I C + WS P C + + Q P Sbjct: 895 TVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL---GHCQAPDHFLF 951 Query: 521 SPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQV 580 + + +NA + T++ + F ++T D P+ V + Sbjct: 952 A---KLKTQTNASDFPIGTSLKYECRPEYYGRPF-------SITCLDNLVWSSPKDVCKR 1001 Query: 581 LTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK----------------------- 617 + PD + M +H+ TD VGS ++NY Sbjct: 1002 KSCKTPPDPVNGM-----VHVITDIQVGS---RINYSCTTGHRLIGHSSAECILSGNAAH 1053 Query: 618 ------EIEKESCGDPGTPLYGIREGDGFS-NRD------VLRFECQFG------FELIG 658 ++ CG P T I GD S NR+ V+ + C G FEL+G Sbjct: 1054 WSTKPPICQRIPCGLPPT----IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 1109 Query: 659 EKSIVCQENNQ----WSANIPICIFP 680 E SI C N+ WS P CI P Sbjct: 1110 EPSIYCTSNDDQVGIWSGPAPQCIIP 1135 Score = 60.8 bits (146), Expect = 2e-08 Identities = 136/619 (21%), Positives = 200/619 (32%), Gaps = 134/619 (21%) Query: 648 FECQFGFELIGEKSIVCQ---ENNQWSANIPIC--IFPCLSNFTAPMGTVLSPD---YPE 699 F C GF+L G + C + W++++P+C IF C S P G +P Sbjct: 834 FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF-CPSPPVIPNGRHTGKPLEVFPF 892 Query: 700 GYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD---SPESPILGTFTGAEV 756 G N C DP SF D ES + G+ S +P G + Sbjct: 893 GKTVNYTC------DPHPDRGTSF-DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 945 Query: 757 PSHL--------TSNSHI---LRLEFQADHSMSGRGFNITY----------NTFGHNECP 795 P H T+ S L+++ GR F+IT + C Sbjct: 946 PDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCK 1005 Query: 796 DPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA- 853 P P+N + Q+GS I+ C G + G + CIL WS P C Sbjct: 1006 TPPDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNAAHWSTKPPICQRI 1064 Query: 854 PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDV 908 PCG + +G +S ++ S+ PG + FE N D Sbjct: 1065 PCGLPPTIANGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 1121 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESV 963 + + GP + V L S + ++ L R GF + + Sbjct: 1122 VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 1181 Query: 964 TVNTYS---------CLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCE 1011 +N + C P +H R D FS G V +SC+ GY L + C Sbjct: 1182 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 1241 Query: 1012 KNHWWSHPLPTCDALCGGDVRGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF 1069 WS PTC+ D G +G +L +P +L VD +G Q Sbjct: 1242 PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ--- 1291 Query: 1070 HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG 1129 L GS + AG+ + + + Sbjct: 1292 --------------------------LKGSSASYCVLAGMESLWNSSVPVCEQIF----- 1320 Query: 1130 FNITFSEYNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEI 1180 C P + G G F G + ++C + + L G S I Sbjct: 1321 ------------CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTI 1368 Query: 1181 ICLGG--GRRVWSAPLPRC 1197 C G VWS+P PRC Sbjct: 1369 RCTSDPQGNGVWSSPAPRC 1387 Score = 60.5 bits (145), Expect = 3e-08 Identities = 132/647 (20%), Positives = 223/647 (34%), Gaps = 127/647 (19%) Query: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIA 1372 C +P P G +G GS I Y C GY L GSS C+ +G+ WD P C Sbjct: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163 Query: 1373 ECGGRFKGESSGRILSPGYP-FPYDN--NLRCMWMIEVDPGNIVSLQFL-----AFDTEA 1424 G ++G +S F Y + RC +PG+ F + + Sbjct: 164 IPCGLPPTITNGDFISTNRENFHYGSVVTYRC------NPGSGGRKVFELVGEPSIYCTS 217 Query: 1425 SHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLN--IVTIQFDTDF-----YISKSGFA 1477 + D + +W GP ++ + + + GI + N + ++ +F ++ K Sbjct: 218 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277 Query: 1478 IQFSS---------SVATACRDPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEER 1525 ++ + S + C+ P ++ R + D PG V + C+PGY+L+G Sbjct: 278 VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS 337 Query: 1526 ITCIQVENRYFWQPSPPVCIAPCGGNLTGS--SGFILSPNFPHPYPHSRDCDWTITVNAD 1583 + C + W P+ P C + G +G +L P Sbjct: 338 MRCTPQGD---WSPAAPTCEVKSCDDFMGQLLNGRVLFP--------------------- 373 Query: 1584 YVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS 1643 ++ + DF+ D L GS + +ES N+ Sbjct: 374 -------VNLQLGAKVDFVC-----DEGFQLKGSSASYCVLAGMESLWNS---------- 411 Query: 1644 VSYTGFHLEYKAKLRESCFDPGN--IMNGTRLGMD---YKLGSTVTYYCD------AGYV 1692 + E F P I NG G + G TV Y CD + Sbjct: 412 ----------SVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 461 Query: 1693 LQGYSTLTCIMGDDGRPGWNRALP------SCHAPCGSRSTGSEGTVLSPNYPKNYSVGH 1746 L G ST+ C G W+ P C AP + + ++P S+ + Sbjct: 462 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521 Query: 1747 NC-VYSIAVPKEFVVFGQFVFFQTSLHDVVE---VYDGPTQQSSLLSSLSGSHSGESLPL 1802 C P V+ +S DV + P + ++ ++ G + Sbjct: 522 ECRPEYYGRPFSITCLDNLVW--SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 579 Query: 1803 S--SGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVG 1857 S +G+++ ++ ++ H+ + P C P G I F G Sbjct: 580 SCTTGHRLIGHSSAECILSGNAAHWSTKP-PICQRIPCGLPPTIANGDFISTNRENFHYG 638 Query: 1858 SSVLFDCNPG------YILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1898 S V + CNPG + L G +I C + + + W+ P CI+P Sbjct: 639 SVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685 Score = 60.1 bits (144), Expect = 4e-08 Identities = 104/479 (21%), Positives = 156/479 (32%), Gaps = 110/479 (22%) Query: 769 LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINAR-RFGDNFQLGSSIS 817 L ++ SGR F+I + C +P P+N Q GS I Sbjct: 69 LNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIK 128 Query: 818 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG-APCGGHFSAPSGVILSPGWPGYYK 876 C +G+ + G+ + TCI+ V+W P C PCG + +G +S ++ Sbjct: 129 YSCTKGY-RLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHY 187 Query: 877 DSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVP 931 S+ PG + FE N D + + GP +P N P Sbjct: 188 GSV---VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP---APQCIIPNKCTPP 241 Query: 932 Q----FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 974 L S + ++ L R GF + + +N + C P Sbjct: 242 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301 Query: 975 IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 1031 +H R D FS G V +SC+ GY L + C WS PTC+ D Sbjct: 302 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361 Query: 1032 RGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1089 G +G +L +P +L VD +G Q Sbjct: 362 MGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ----------------------- 391 Query: 1090 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1149 L GS + AG+ + + + C P + Sbjct: 392 ------LKGSSASYCVLAGMESLWNSSVPVCEQIF-----------------CPSPPVIP 428 Query: 1150 YGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEIICLGG--GRRVWSAPLPRC 1197 G G F G T+ ++C + + L G S I C G VWS+P PRC Sbjct: 429 NGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487 Score = 59.7 bits (143), Expect = 5e-08 Identities = 139/652 (21%), Positives = 216/652 (33%), Gaps = 142/652 (21%) Query: 1142 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC-V 1198 C +P P G + G + +SC+ GYRL G+S C + G +W P C Sbjct: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163 Query: 1199 AECGASATNNEGILLSPNYPLNYENNH-ECIYSIQVQAGKGINISARTFHL--------- 1248 CG T G +S N EN H + + + G G + F L Sbjct: 164 IPCGLPPTITNGDFIS----TNRENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCT 216 Query: 1249 AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQ 1303 + D + I+ G + T ++ L S + L+ +EF +G + Sbjct: 217 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 276 Query: 1304 LVYTSF------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSS 1351 V EL C P + D+ +F+ G + Y C PGY L G++ Sbjct: 277 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 336 Query: 1352 LLKCMTGERRAWDYPLPSCIAECGGRFKGE-SSGRILSPGYPFPYDNNLRCMWMIEVDPG 1410 ++C + W P+C + F G+ +GR+L FP + L D G Sbjct: 337 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-----FPVNLQLGAKVDFVCDEG 389 Query: 1411 NIVSLQFLAFDTEASHDIL----RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFD 1466 F + AS+ +L +W+ + S +IP G H+ + F Sbjct: 390 ------FQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF- 442 Query: 1467 TDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDP------GYEL 1520 G TV + CDP ++L Sbjct: 443 ----------------------------------------GKTVNYTCDPHPDRGTSFDL 462 Query: 1521 QGEERITCI-QVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPN---FPHPYPHSRDCDW 1576 GE I C + W P C G G +P+ F + D+ Sbjct: 463 IGESTIRCTSDPQGNGVWSSPAPRC---------GILGHCQAPDHFLFAKLKTQTNASDF 513 Query: 1577 TITVNADYVISLAFIS--FSIEPNYDFLY-----------IYDGPDSNSPLIGSFQDSKL 1623 I + Y + FSI + ++ PD + ++ D ++ Sbjct: 514 PIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 573 Query: 1624 PERIESSSNTMH-LAFRSDGSVSYTGFHLEYKAK----LRESCFDPGNIMNGTRLGM--- 1675 RI S T H L S +G + K R C P I NG + Sbjct: 574 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633 Query: 1676 DYKLGSTVTYYCDAG------YVLQGYSTLTCIMGDDGRPGWNRALPSCHAP 1721 ++ GS VTY C+ G + L G ++ C DD W+ P C P Sbjct: 634 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685 Score = 54.7 bits (130), Expect = 2e-06 Identities = 61/257 (23%), Positives = 92/257 (35%), Gaps = 50/257 (19%) Query: 640 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 699 FS +V+ F CQ GF + G + + CQ N+W +P C S P VL + + Sbjct: 706 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPDVLHAERTQ 760 Query: 700 GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 757 +N + PG + S +DL GD SP +P + + Sbjct: 761 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 812 Query: 758 SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 794 L N +L +++F D +G + +Y E C Sbjct: 813 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 871 Query: 795 PDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQGTETITCIL-MDGKVMWS 845 P P + N R G + F G +++ C+ G TI C G +WS Sbjct: 872 PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931 Query: 846 GLIPKCGAPCGGHFSAP 862 P+CG GH AP Sbjct: 932 SPAPRCGIL--GHCQAP 946 Score = 54.7 bits (130), Expect = 2e-06 Identities = 61/257 (23%), Positives = 92/257 (35%), Gaps = 50/257 (19%) Query: 640 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 699 FS +V+ F CQ GF + G + + CQ N+W +P C S P VL + + Sbjct: 1156 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPDVLHAERTQ 1210 Query: 700 GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 757 +N + PG + S +DL GD SP +P + + Sbjct: 1211 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 1262 Query: 758 SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 794 L N +L +++F D +G + +Y E C Sbjct: 1263 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 1321 Query: 795 PDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQGTETITCIL-MDGKVMWS 845 P P + N R G + F G +++ C+ G TI C G +WS Sbjct: 1322 PSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381 Query: 846 GLIPKCGAPCGGHFSAP 862 P+CG GH AP Sbjct: 1382 SPAPRCGIL--GHCQAP 1396 Score = 51.2 bits (121), Expect = 2e-05 Identities = 124/627 (19%), Positives = 214/627 (34%), Gaps = 127/627 (20%) Query: 1334 GSTIIYGCNPGYTLHGSSLLKC-MTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYP 1392 GS I Y C G+ L G S +C ++G W P C G ++G +S Sbjct: 574 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633 Query: 1393 -FPYDN--NLRCMWMIEVDPGNIVSLQFL-----AFDTEASHDILRVWDGPPENDMLLKE 1444 F Y + RC +PG+ F + ++ D + +W GP ++ + Sbjct: 634 NFHYGSVVTYRC------NPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687 Query: 1445 ISGSLIPEGIHSTLN--IVTIQFDTDF-----YISKSGFAIQFSS---------SVATAC 1488 + + GI + N + ++ +F ++ K ++ + S + C Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747 Query: 1489 RDPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1545 + P ++ R + D PG V + C+PGY+L+G + C + W P+ P C Sbjct: 748 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD---WSPAAPTCE 804 Query: 1546 APCGGNLTGS--SGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLY 1603 + G +G +L P ++ + DF+ Sbjct: 805 VKSCDDFMGQLLNGRVLFP----------------------------VNLQLGAKVDFVC 836 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1663 D L GS + +ES N+ + E F Sbjct: 837 -----DEGFQLKGSSASYCVLAGMESLWNS--------------------SVPVCEQIFC 871 Query: 1664 PGN--IMNGTRLGMD---YKLGSTVTYYCD------AGYVLQGYSTLTCIMGDDGRPGWN 1712 P I NG G + G TV Y CD + L G ST+ C G W+ Sbjct: 872 PSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931 Query: 1713 RALP------SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNC-VYSIAVPKEFVVFGQFV 1765 P C AP + + ++P S+ + C P V Sbjct: 932 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLV 991 Query: 1766 FFQTSLHDVVE---VYDGPTQQSSLLSSLSGSHSGESLPLS--SGNQITIRFTSVGPITA 1820 + +S DV + P + ++ ++ G + S +G+++ ++ ++ Sbjct: 992 W--SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSG 1049 Query: 1821 KGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVGSSVLFDCNPG------YILH 1871 H+ + P C P G I F GS V + CNPG + L Sbjct: 1050 NAAHWSTKP-PICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELV 1108 Query: 1872 GSIAIRCETVPNSLAQWNDSLPTCIVP 1898 G +I C + + + W+ P CI+P Sbjct: 1109 GEPSIYCTSNDDQVGIWSGPAPQCIIP 1135 Score = 51.2 bits (121), Expect = 2e-05 Identities = 184/870 (21%), Positives = 288/870 (33%), Gaps = 206/870 (23%) Query: 461 DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFT 520 + LG+ V F CDE + L+G+ + C +A + + W+ PVC+ C S P+G T Sbjct: 1275 NLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHT 1333 Query: 521 SPN---FPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGD----GGEVGD 573 FPF N C FDL IG T+ G Sbjct: 1334 GKPLEVFPFGKAVNYTC----------DPHPDRGTSFDL-IGESTIRCTSDPQGNGVWSS 1382 Query: 574 PRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY----------------- 616 P +L PD + L QT+ S +G + Y Sbjct: 1383 PAPRCGILGHCQAPDHFLFAK----LKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 1438 Query: 617 -------KEI-EKESCGDPGTPLYG-IREGDGFSNRDVLRFECQFGFELIGEKSIVC--- 664 K++ +++SC P P+ G + + + C G LIG S C Sbjct: 1439 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS 1498 Query: 665 QENNQWSANIPIC-IFPCLSNFTAPMGTVLSPD-----------YPEGYGNNLNCIWTII 712 WS PIC PC T G +S + Y G+ ++ ++ Sbjct: 1499 GNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELV 1558 Query: 713 SDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQ 772 +P I+ + ND D + + G +P+ I Sbjct: 1559 GEPS--IYCTSND-------DQVGIWSGPAPQCII------------------------- 1584 Query: 773 ADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQG 829 N+C P + N DN F L + C+ GF+ +G Sbjct: 1585 ------------------PNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFV-MKG 1624 Query: 830 TETITCILMDGKVMWSGLIPKCGAPC--------GGH-------FSAPSGVILS--PGWP 872 + C ++ W +P C C G H FS V S PG+ Sbjct: 1625 PRRVKCQALN---KWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1681 Query: 873 GYYKDSLNC----EWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPL---LGSY 925 SL+C +W EA P ++K + + F +L + +L PL LG+ Sbjct: 1682 LRGAASLHCTPQGDWSPEA-PRCAVK-SCDDFLGQLPHG--------RVLFPLNLQLGAK 1731 Query: 926 NGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYG- 983 + F S+ + + S NN + C +P ++GR G Sbjct: 1732 VSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPV------CEHIFCPNPPAILNGRHTGT 1785 Query: 984 --HDFSIGSTVSFSCD------SGYRLSHEEPLLCEK----NHWWSHPLPTCD-ALCGGD 1030 D G +S++CD + L E + C N WS P P C+ ++ G Sbjct: 1786 PSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGH 1845 Query: 1031 VRGPSG-TILSPGYP--EF-YPNSLNCTWTVDVTH-GKGVQFN-FHTFHLEDHHDYLLIT 1084 + P SP P +F +P + + + GK + D Sbjct: 1846 CKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRK 1905 Query: 1085 ENGSFTQPLARL----TGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---- 1136 G +P + T + T+N FR L + G N+T+ + Sbjct: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFR--LIGSPSTTCLVSGNNVTWDKKAPI 1963 Query: 1137 YNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSCSSG------YRLEGTSEIICLGGGR 1187 + CE P G N F G +T+ C +G + L G I C Sbjct: 1964 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDD 2023 Query: 1188 R--VWSAPLPRCVAECGASATNNEGILLSP 1215 + VWS+P PRC++ +A E + P Sbjct: 2024 QVGVWSSPPPRCISTNKCTAPEVENAIRVP 2053 Score = 49.3 bits (116), Expect = 7e-05 Identities = 27/61 (44%), Positives = 33/61 (54%), Gaps = 2/61 (3%) Query: 137 SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 SC P P G+++ T VG +I YSC TG+ L GH CI S NTA W PIC Sbjct: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSTKPPIC 1511 Query: 196 R 196 + Sbjct: 1512 Q 1512 Score = 49.3 bits (116), Expect = 7e-05 Identities = 70/277 (25%), Positives = 100/277 (36%), Gaps = 34/277 (12%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C P +P NG + +D +GS + +SC + L G S C ++ A WS P+C+ Sbjct: 1454 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAEC-ILSGNTAHWSTKPPICQ 1512 Query: 505 VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 562 CG +G F S N F Y S V+T N + FE Y T Sbjct: 1513 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNLGSRGRKVFELVGEPSIYCT 1566 Query: 563 LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 612 G P + P+ ++VS + ++ + E GF Sbjct: 1567 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1626 Query: 613 -----KVNYKEIEKESCGDPGTPLYGIREG-------DGFSNRDVLRFECQFGFELIGEK 660 +N E E SC P I G D FS + + C+ G++L G Sbjct: 1627 RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1686 Query: 661 SIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSP 695 S+ C WS P C +F P G VL P Sbjct: 1687 SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723 Score = 48.1 bits (113), Expect = 2e-04 Identities = 140/645 (21%), Positives = 212/645 (32%), Gaps = 136/645 (21%) Query: 654 FELIGEKSIVCQE----NNQWSANIPICI-------------FPCLS------NFTAPMG 690 F LIGE +I C N WS+ P C FP S +F P+G Sbjct: 1810 FNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVG 1869 Query: 691 TVLSPDYPEGYGNNL-------NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSP 743 T L+ + GY + N +W+ + D R K P Sbjct: 1870 TSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRR-------------------KSCGPP 1910 Query: 744 ESPILGTF---TGAEVPSHLT-SNSHILRLEFQADHSMSGRGFNITYNTFGHN----ECP 795 P G T + S + S + RL + G N+T++ C Sbjct: 1911 PEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE 1970 Query: 796 DPGIPINARRFGDN---FQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSG 846 P N + +N F G+ ++ C G + G +I C D +V +WS Sbjct: 1971 PPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSS 2030 Query: 847 LIPKCGAPCGGHFSAPSGVILSPGWPGYYKDS----LNCEWVIEAEPGHSIKI-TFERFQ 901 P+C + I PG ++ + C+ H+++ T R+ Sbjct: 2031 PPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWG 2090 Query: 902 TELNYDVLEVHDGPNLL--SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 959 +L + P +L L + Q +F S Y L + Sbjct: 2091 PKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWS 2150 Query: 960 YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 1014 E+ SC D G HGR + +G+ VSF CD G+RL S +L Sbjct: 2151 PEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKA 2210 Query: 1015 WWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHL 1074 W+ +P C+ I P P T D+ +GK + + T H Sbjct: 2211 LWNSSVPVCE------------QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDT-HP 2257 Query: 1075 EDHHDYLLITE-----------NGSFTQPLARL-----TGSDLPPTINAGLYGNFRAQLR 1118 + + LI E NG ++ P R PP I G Y L Sbjct: 2258 DRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL- 2316 Query: 1119 FISDFSISY---EGFNITFSEYNLEPCEDPGI----PQYGSRIGFNFGI----------- 1160 ++ +ISY G+ + + C D GI Y + +F + Sbjct: 2317 YLPGMTISYICDPGYLLVGKGFIF--CTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEM 2374 Query: 1161 ------GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1199 GD +T C GY LEG+ C R W PL +C + Sbjct: 2375 KKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDR--WDPPLAKCTS 2417 Score = 47.0 bits (110), Expect = 3e-04 Identities = 68/277 (24%), Positives = 99/277 (35%), Gaps = 34/277 (12%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C P +P NG + +D +GS + +SC + L G S C A WS P+C+ Sbjct: 554 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA-AHWSTKPPICQ 612 Query: 505 VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 562 CG +G F S N F Y S V+T N + FE Y T Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 666 Query: 563 LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 612 G P + P+ ++VS + ++ + E GF Sbjct: 667 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 726 Query: 613 -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 660 +N E E SC P + R+ D FS + + C+ G++L G Sbjct: 727 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 786 Query: 661 SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 695 S+ C WS P C +F + G VL P Sbjct: 787 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 823 Score = 47.0 bits (110), Expect = 3e-04 Identities = 68/277 (24%), Positives = 99/277 (35%), Gaps = 34/277 (12%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C P +P NG + +D +GS + +SC + L G S C A WS P+C+ Sbjct: 1004 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA-AHWSTKPPICQ 1062 Query: 505 VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 562 CG +G F S N F Y S V+T N + FE Y T Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 1116 Query: 563 LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 612 G P + P+ ++VS + ++ + E GF Sbjct: 1117 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1176 Query: 613 -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 660 +N E E SC P + R+ D FS + + C+ G++L G Sbjct: 1177 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 1236 Query: 661 SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 695 S+ C WS P C +F + G VL P Sbjct: 1237 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 1273 Score = 46.6 bits (109), Expect = 5e-04 Identities = 25/66 (37%), Positives = 34/66 (51%), Gaps = 2/66 (3%) Query: 131 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 189 + + SC NP P G+++ + G +I+YSC GY L G TCI S +T WD Sbjct: 97 DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWD 155 Query: 190 FPVPIC 195 PIC Sbjct: 156 NETPIC 161 Score = 46.6 bits (109), Expect = 5e-04 Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%) Query: 131 EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 189 + + SCG P P G+++ T G + YSC G+ L G P TC+ S N +WD Sbjct: 1900 DNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV-SGNNVTWD 1958 Query: 190 FPVPIC 195 PIC Sbjct: 1959 KKAPIC 1964 Score = 45.1 bits (105), Expect = 0.001 Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 2/79 (2%) Query: 1487 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC- 1544 +CR+P P+NG + G + G + + C GY L G TCI + W P+C Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162 Query: 1545 IAPCGGNLTGSSGFILSPN 1563 PCG T ++G +S N Sbjct: 163 RIPCGLPPTITNGDFISTN 181 Score = 44.3 bits (103), Expect = 0.002 Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Query: 436 EGGIKTASNLCPDPGEPENGKRIGS---DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 492 E + + S +C P E +G+ S +FS G V +SC+ Y L+GA S+ C + Sbjct: 1637 EPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD- 1695 Query: 493 FAAWSDHRPVCKVKTCGSNL-QGPSGTFTSP 522 WS P C VK+C L Q P G P Sbjct: 1696 ---WSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723 Score = 44.3 bits (103), Expect = 0.002 Identities = 83/385 (21%), Positives = 138/385 (35%), Gaps = 90/385 (23%) Query: 154 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGII- 212 F VG + Y C GY ++C+ N V W CR + +CG +G++ Sbjct: 1866 FPVGTSLNYECRPGYFGKMF-SISCLENLV----WSSVEDNCRRK-SCGPPPEPFNGMVH 1919 Query: 213 --SSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGM 270 + F + + + + + ++ P T + + ++K EI EPP Sbjct: 1920 INTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPP------- 1972 Query: 271 NIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGELEEHNRTTTGAIAV 330 P ISN ++ SN+R + + +T+ TG E G ++ Sbjct: 1973 ----PTISNGDFY-------SNNR-----TSFHNGTVVTYQCHTGPDGEQLFELVGERSI 2016 Query: 331 ASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTSKDGLSPHP---ADTQSTRR 387 T S++ +V V S SP P + + T Sbjct: 2017 YCT-----------------SKDDQVGVWS---------------SPPPRCISTNKCTAP 2044 Query: 388 RPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPG--KDNSNKFSILNEGG----IKT 441 +A ++ + +T ++ F+ PG S+ G + Sbjct: 2045 EVENAIRVPGNRSFFTLTEIIR---------FRCQPGFVMVGSHTVQCQTNGRWGPKLPH 2095 Query: 442 ASNLCPDPGEPENGKRIGS---DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSD 498 S +C P E +G+ S +FS G V +SC+ Y L+GA S+ C + WS Sbjct: 2096 CSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD----WSP 2151 Query: 499 HRPVCKVKTCGSNL-QGPSGTFTSP 522 P C VK+C L Q P G P Sbjct: 2152 EAPRCTVKSCDDFLGQLPHGRVLLP 2176 Score = 43.9 bits (102), Expect = 0.003 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 7/76 (9%) Query: 436 EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 492 E + + S +C PD E +R +FS G V +SC+ Y L+GA S+ C + Sbjct: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD- 345 Query: 493 FAAWSDHRPVCKVKTC 508 WS P C+VK+C Sbjct: 346 ---WSPAAPTCEVKSC 358 Score = 43.9 bits (102), Expect = 0.003 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 7/76 (9%) Query: 436 EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 492 E + + S +C PD E +R +FS G V +SC+ Y L+GA S+ C + Sbjct: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD- 1245 Query: 493 FAAWSDHRPVCKVKTC 508 WS P C+VK+C Sbjct: 1246 ---WSPAAPTCEVKSC 1258 Score = 37.0 bits (84), Expect = 0.36 Identities = 23/66 (34%), Positives = 28/66 (42%), Gaps = 7/66 (10%) Query: 446 CPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502 CP P + +NG IG SL G T+ + CD Y+L G I C WS Sbjct: 2298 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTD----QGIWSQLDHY 2353 Query: 503 CKVKTC 508 CK C Sbjct: 2354 CKEVNC 2359 Score = 36.6 bits (83), Expect = 0.47 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 19/113 (16%) Query: 402 AVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPD--------PGEPE 453 +VVT+R + SRG K+F + + N+ + S P P E Sbjct: 1539 SVVTYRC----NLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 1594 Query: 454 NGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 NG + + FSL V+F C +V++G + + CQ + + W P C Sbjct: 1595 NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 1643 Score = 35.0 bits (79), Expect = 1.4 Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 24/105 (22%) Query: 419 FKLFPGKDNSNKFSILNEGGIKTASN--------------LCPD---PGEPENGKRIGSD 461 ++ PG F ++ E I SN + P+ P ENG + + Sbjct: 193 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252 Query: 462 ---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 FSL V+F C +V++G + + CQ + + W P C Sbjct: 253 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 293 Score = 35.0 bits (79), Expect = 1.4 Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 24/105 (22%) Query: 419 FKLFPGKDNSNKFSILNEGGIKTASN--------------LCPD---PGEPENGKRIGSD 461 ++ PG F ++ E I SN + P+ P ENG + + Sbjct: 1093 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 1152 Query: 462 ---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 FSL V+F C +V++G + + CQ + + W P C Sbjct: 1153 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 1193 Score = 33.9 bits (76), Expect = 3.0 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%) Query: 461 DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 508 + LG+ V F CDE + L+G + C +A + A W+ PVC+ C Sbjct: 2178 NLQLGAKVSFVCDEGFRLKGRSASHCV-LAGMKALWNSSVPVCEQIFC 2224 Score = 33.5 bits (75), Expect = 4.0 Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 2/48 (4%) Query: 2028 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM 2075 Y GD V+ +C+ GY+L+G C RW+ P+ C ++ A+ Sbjct: 2378 YHYGDYVTLKCEDGYTLEGSPWSQCQADD--RWDPPLAKCTSRTHDAL 2423 Score = 33.1 bits (74), Expect = 5.2 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%) Query: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184 E + SC PP VL+ R F G ++ YSC GY L G + C Sbjct: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 343 Query: 185 TASWDFPVPICR---AEDACGGTMRG 207 W P C +D G + G Sbjct: 344 -GDWSPAAPTCEVKSCDDFMGQLLNG 368 Score = 33.1 bits (74), Expect = 5.2 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%) Query: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184 E + SC PP VL+ R F G ++ YSC GY L G + C Sbjct: 737 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 793 Query: 185 TASWDFPVPICR---AEDACGGTMRG 207 W P C +D G + G Sbjct: 794 -GDWSPAAPTCEVKSCDDFMGQLLNG 818 Score = 33.1 bits (74), Expect = 5.2 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%) Query: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184 E + SC PP VL+ R F G ++ YSC GY L G + C Sbjct: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 1243 Query: 185 TASWDFPVPICR---AEDACGGTMRG 207 W P C +D G + G Sbjct: 1244 -GDWSPAAPTCEVKSCDDFMGQLLNG 1268 Score = 32.7 bits (73), Expect = 6.8 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%) Query: 134 QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 184 Q CG P G T F G + Y C G + L G P + C +N Sbjct: 612 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671 Query: 185 TASWDFPVPICRAEDAC 201 W P P C + C Sbjct: 672 VGIWSGPAPQCIIPNKC 688 Score = 32.7 bits (73), Expect = 6.8 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%) Query: 134 QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 184 Q CG P G T F G + Y C G + L G P + C +N Sbjct: 1062 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 1121 Query: 185 TASWDFPVPICRAEDAC 201 W P P C + C Sbjct: 1122 VGIWSGPAPQCIIPNKC 1138 Score = 32.7 bits (73), Expect = 6.8 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%) Query: 134 QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 184 Q CG P G T F G + Y C G + L G P + C +N Sbjct: 1512 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1571 Query: 185 TASWDFPVPICRAEDAC 201 W P P C + C Sbjct: 1572 VGIWSGPAPQCIIPNKC 1588 Score = 32.3 bits (72), Expect = 8.9 Identities = 20/73 (27%), Positives = 25/73 (34%), Gaps = 9/73 (12%) Query: 138 CGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVNTASW 188 CG P G T F G + Y C G + L G P + C +N W Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225 Query: 189 DFPVPICRAEDAC 201 P P C + C Sbjct: 226 SGPAPQCIIPNKC 238 >gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens] Length = 2039 Score = 399 bits (1025), Expect = e-110 Identities = 476/1934 (24%), Positives = 720/1934 (37%), Gaps = 357/1934 (18%) Query: 1658 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 R+SC +P + +NG + + GS + Y C GY L G S+ TCI+ D W+ P Sbjct: 101 RKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGD-TVIWDNETP 159 Query: 1717 SC-HAPCGSRSTGSEGTVLSPNYPKNYSVG----HNCVYSIAVPKEFVVFGQFVFFQTSL 1771 C PCG T + G +S N +N+ G + C K F + G+ + TS Sbjct: 160 ICDRIPCGLPPTITNGDFISTNR-ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218 Query: 1772 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKGFHFV 1826 D V ++ GP Q + + + + + +S + + F KG V Sbjct: 219 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 278 Query: 1827 Y-QAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAI 1876 QA+ + CS V +P +R + F+ G V + C PGY L G+ ++ Sbjct: 279 KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 338 Query: 1877 RCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGA 1935 RC W+ + PTC + C + G +L+ P + L EG Sbjct: 339 RC----TPQGDWSPAAPTCEVKSCDDFM----GQLLNGRVLFPVNLQLGAKVDFVCDEGF 390 Query: 1936 GIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISV 1995 ++ S+ +SL + S + V Sbjct: 391 QLKGSSASYCVLAGMESL-----------------------------------WNSSVPV 415 Query: 1996 SAAGFHLEYTAIGLDSCPEPQTPSSGIKIG---DRYMVGDVVSFQCD------QGYSLQG 2046 F CP P +G G + + G V++ CD + L G Sbjct: 416 CEQIF-----------CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIG 464 Query: 2047 HSHITCMPGPVRR--WNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLP 2104 S I C P W+ P P C G++ P Sbjct: 465 ESTIRCTSDPQGNGVWSSPAPRC------------GILGHCQAPD--------------- 497 Query: 2105 IGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD 2164 H F T+T + T + P+ FS T +L + S Sbjct: 498 -----HFLFAKLKTQT-------NASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSP 545 Query: 2165 YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALT 2223 K+ +SC P NG V + D VG I++ C G+ LIG+S+ Sbjct: 546 KDVCKR-----------KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE 594 Query: 2224 C-LHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGI 2281 C L G + +W+ P C+ + CG T NG S + + + R PG+G Sbjct: 595 CILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTY---RCNPGSGG 651 Query: 2282 YINFTVLQTEPIY-----DFITVWDGPDQ--------NSPQIGQFSGNTALESVYSTSNQ 2328 F ++ IY D + +W GP P + + S++S + Sbjct: 652 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV 711 Query: 2329 ILIKFHSDFTTSGFFVLSYHAYQ---------LRVCQPPPPVPNAEILTED-DEFEIGDI 2378 + + F G + A RVCQPPP V +AE D D F G Sbjct: 712 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 771 Query: 2379 IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSY 2438 + Y C PG+ L G A + C + A P C+V + + G +L P Sbjct: 772 VFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP------ 823 Query: 2439 PNLQMCA-WSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFN 2497 NLQ+ A ++G+ + G + VL + ++S+ Sbjct: 824 VNLQLGAKVDFVCDEGFQL-------------------KGSSASYCVLAGMESLWNSSVP 864 Query: 2498 ITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQL-----NSVV 2552 + +C +P P+G TG L V Sbjct: 865 VCEQ-------------------------IFCPSPPVIPNG---RHTGKPLEVFPFGKAV 896 Query: 2553 RWAC----DRG--FRLVGKSSAVCRKSSYGYHAWDAPVPACQAIS-CGIP--------KA 2597 + C DRG F L+G+S+ C G W +P P C + C P K Sbjct: 897 NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKT 956 Query: 2598 PTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSI 2657 TN +D+ +GT + Y C Y +T C + WS+ C +C + Sbjct: 957 QTN----ASDFPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKDV--CKRKSCKTP 1007 Query: 2658 NSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNG-TWSWRNERPYCQI 2716 + +G ++ + + +++ +SC G+ +G +S EC+ +G T W + P CQ Sbjct: 1008 PDPV--NGMVHVI--TDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQR 1063 Query: 2717 ISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLG------FMLVGSAVRECLSS----G 2763 I CG PT NG+ I T YGS + C+LG F LVG C S+ G Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1123 Query: 2764 LWSESETRCLAGHCGIPELIVNGQVIGEN---YGYRDTVVYQCNPGFRLIGSSVRICQQD 2820 +WS +C+ + P + NG ++ +N + + V ++C PGF + G CQ Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 1183 Query: 2821 HNWSGQLPSCVPVSCGHPGSPIYGR---TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQA 2877 + W +LPSC V C P ++G + + F+ V +SC GY ++G C Sbjct: 1184 NKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTP 1242 Query: 2878 NRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHG------NFTYGTVVFYDCNPGYFLFG 2931 WS P C V +C D ++ HG N G V + C+ G+ L G Sbjct: 1243 QGDWSPEAPRCAVKSCDD--------FLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKG 1294 Query: 2932 SSVLICQPNGQ---WDKPLPECIMIDCGHP---------GVPPNAVLSGEKYTFGSTVHY 2979 SSV C G W+ +P C I C +P G P + G++ ++ H Sbjct: 1295 SSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHP 1354 Query: 2980 SCTGKRSLLGQSSRTCQL----NGHWSGSQPHCS-GDATGTCGDPGTPGHGSR----QES 3030 +L+G+S+ C NG WS P C G C P S + Sbjct: 1355 DRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF 1414 Query: 3031 NFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDG 3090 F +++ Y C GY +CL N W+ + C+ CG P NG V Sbjct: 1415 EFPVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTD 1473 Query: 3091 TTFSSSVIYSCMEGYILSGPSVRQCTANG---TWSGTLPNCTIISCGDPGIPANGLRYGD 3147 T F S+V YSC EG+ L G C +G TW P C IISC P +NG Y + Sbjct: 1474 TQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSN 1533 Query: 3148 D---YVVGQNVSYMCQPG----YTMELNGSRIRTCTIN----GTWSGVMPTCRAVTCPTP 3196 + + G V+Y C G EL G R CT G WS P C + T Sbjct: 1534 NRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTA 1593 Query: 3197 PQISNG-RLEGTN--FDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGD 3253 P++ N R+ G F I + C PG+ + + C NG W ++P C + C Sbjct: 1594 PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC-SRVCQP 1652 Query: 3254 PGIPAQGKR---EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT 3310 P G+ +F EV +SC + L G+++ C G WS +P C T Sbjct: 1653 PPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC---TVK 1709 Query: 3311 SCEN-PGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL---PDLTWSGIQPEC 3366 SC++ G HG Q+G+ V F C +G L+G + C+ W+ P C Sbjct: 1710 SCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVC 1769 Query: 3367 IPHSCKQPETPAHANVVGM---DLPSHGYTLIYTCQP------GFFLAGGTEHRVCRSD- 3416 C P + G D+P +G + Y C F L G + R C SD Sbjct: 1770 EQIFCPNPPAILNGRHTGTPFGDIP-YGKEISYACDTHPDRGMTFNLIGESSIR-CTSDP 1827 Query: 3417 ---NTWTGKVPICE 3427 W+ P CE Sbjct: 1828 QGNGVWSSPAPRCE 1841 Score = 321 bits (823), Expect = 7e-87 Identities = 274/992 (27%), Positives = 411/992 (41%), Gaps = 124/992 (12%) Query: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 C TP P +G + T Q+ S + ++C G RL+G SSA C S H W P CQ Sbjct: 1004 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAH-WSTKPPICQ 1062 Query: 2589 AISCGIPKAPTNGGILTTD---YLVGTRVTYFCNDGYRLSSK-ELT---TAVCQSD---- 2637 I CG+P NG ++T+ + G+ VTY CN G R EL + C S+ Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1122 Query: 2638 GTWSNHNKTPRCVV---VTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGP 2694 G WS P+C++ T P++ + IL N S + V F C PG+ GP Sbjct: 1123 GIWSG--PAPQCIIPNKCTPPNVENGILVSD-----NRSLFSLNEVVEFRCQPGFVMKGP 1175 Query: 2695 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT-------SYGSTAIFTCDL 2747 ++C W E P SC + PP G T S G ++C+ Sbjct: 1176 RRVKC--QALNKWEPELP-----SCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEP 1228 Query: 2748 GFMLVGSAVRECLSSGLWSESETRCLAGHCG--IPELIVNGQVIGENYGYRDTVVYQCNP 2805 G+ L G+A C G WS RC C + +L + N V + C+ Sbjct: 1229 GYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1288 Query: 2806 GFRLIGSSVRICQ---QDHNWSGQLPSCVPVSCGHPGSPIYGRTSGN---GFNFNDVVTF 2859 GFRL GSSV C W+ +P C + C +P + + GR +G + +++ Sbjct: 1289 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1348 Query: 2860 SCN------IGYLMQGPTKAQCQA----NRQWSHPPPMCKVV----NCSDPGIPANSKRE 2905 +C+ + + + G + +C + N WS P P C++ +C P + Sbjct: 1349 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT 1408 Query: 2906 SKIEHGNFTYGTVVFYDCNPGYF--LFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPN 2963 I F GT + Y+C PGYF +F S C N W C CG P P N Sbjct: 1409 IPINDFEFPVGTSLNYECRPGYFGKMFSIS---CLENLVWSSVEDNCRRKSCGPPPEPFN 1465 Query: 2964 AVLSGEKYT-FGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDP 3019 ++ T FGSTV+YSC L+G S TC ++G+ W P C +C P Sbjct: 1466 GMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE---IISCEPP 1522 Query: 3020 GTPGHG---SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQ 3066 T +G S ++F + V Y C TG + L G C + G W+ Sbjct: 1523 PTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPP 1582 Query: 3067 PECKAV-QCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTANGTW 3121 P C + +C P R+ G T + + + C G+++ G QC NG W Sbjct: 1583 PRCISTNKCTAPEVE---NAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRW 1639 Query: 3122 SGTLPNCTIISCGDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTING 3179 LP+C+ + P I + L + D++ GQ V Y C+P Y +L G+ CT G Sbjct: 1640 GPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSY--DLRGAASLHCTPQG 1697 Query: 3180 TWSGVMPTCRAVTCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG 3237 WS P C +C Q+ +GR L N G +S++C G+ L + CV G Sbjct: 1698 DWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAG 1757 Query: 3238 T---WSGEVPQCLPKFCGDPGIPAQGKREGKSF---IYQSEVSFSCN------FPFILVG 3285 W+ VP C FC +P G+ G F Y E+S++C+ F L+G Sbjct: 1758 MKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIG 1817 Query: 3286 SSTRICQAD----GTWSGSSPHCIEPTQTSCENPGVPRHGSQ--NNTFGFQVGSVVQFHC 3339 S+ C +D G WS +P C +C +P ++G + + G + + C Sbjct: 1818 ESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYIC 1877 Query: 3340 KKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLP-----SHGYTL 3394 G+LL G C WS + C +C P N + +L +G + Sbjct: 1878 DPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC---SFPLFMNGISKELEMKKVYHYGDYV 1934 Query: 3395 IYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3426 C+ G+ L G + C++D+ W + C Sbjct: 1935 TLKCEDGYTLEGSPWSQ-CQADDRWDPPLAKC 1965 Score = 299 bits (766), Expect = 3e-80 Identities = 244/822 (29%), Positives = 336/822 (40%), Gaps = 94/822 (11%) Query: 2679 TKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSY 2737 T + + C PGY G P SI CL N W+ +R C+ SC P P NG + + Sbjct: 67 TYLNYECRPGYSGR-PFSIICLKNSVWTGAKDR--CRRKSCRNPPDPVNGMVHVIKGIQF 123 Query: 2738 GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQVIG---E 2791 GS ++C G+ L+GS+ C+ SG +W C CG+P I NG I E Sbjct: 124 GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRE 183 Query: 2792 NYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PVSCGHPG- 2839 N+ Y V Y+CNPG F L+G C + + WSG P C+ P C P Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 243 Query: 2840 -SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2898 + I + + F+ N+VV F C G++M+GP + +CQA +W P C V C P Sbjct: 244 ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPD 302 Query: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH- 2957 +++R + + NF+ G VFY C PGY L G++ + C P G W P C + C Sbjct: 303 VLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361 Query: 2958 -PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDAT 3013 + VL G+ V + C L G S+ C L G W+ S P C + Sbjct: 362 MGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC--EQI 419 Query: 3014 GTCGDPGTPG--HGSRQESNFRTKSTVRYACD------TGYILHGSEERTCLA----NGS 3061 P P H + F TV Y CD T + L G C + NG Sbjct: 420 FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 479 Query: 3062 WTGRQPECKAV-QCGNPG--------TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSV 3112 W+ P C + C P T N F I +S+ Y C Y P Sbjct: 480 WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI-----GTSLKYECRPEY-YGRPFS 533 Query: 3113 RQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSR 3171 C N WS C SC P P NG+ + D VG ++Y C G+ L G Sbjct: 534 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGH--RLIGHS 591 Query: 3172 IRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGT---NFDWGFSISYICSPG--- 3222 C ++G WS P C+ + C PP I+NG T NF +G ++Y C+PG Sbjct: 592 SAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGG 651 Query: 3223 ---YELSFPAVLTCVGN----GTWSGEVPQC-LPKFCGDP----GIPAQGKREGKSFIYQ 3270 +EL + C N G WSG PQC +P C P GI R F Sbjct: 652 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNR--SLFSLN 709 Query: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFG 3328 V F C F++ G CQA W P C C+ P H +Q + Sbjct: 710 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC----SRVCQPPPDVLHAERTQRDKDN 765 Query: 3329 FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ-PETPAHANVVGMDL 3387 F G V + C+ G+ L+G+ + C P WS P C SC + V+ Sbjct: 766 FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN 825 Query: 3388 PSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICE 3427 G + + C GF L G + + ++ W VP+CE Sbjct: 826 LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 867 Score = 272 bits (695), Expect = 5e-72 Identities = 266/1003 (26%), Positives = 398/1003 (39%), Gaps = 129/1003 (12%) Query: 2529 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2584 C+ PE P + T + + + + C G+ G+ S +C K+S W Sbjct: 43 CNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTGAK 96 Query: 2585 PACQAISCGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT-WSN 2642 C+ SC P P NG + + G+++ Y C GYRL T + D W Sbjct: 97 DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWD- 155 Query: 2643 HNKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHG------LG 2693 N+TP C + C P+I +G + N ++ Y + V + C+PG G +G Sbjct: 156 -NETPICDRIPCGLPPTIT-----NGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVG 209 Query: 2694 PASIECLPNG--TWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGS---TAIFTCDLG 2748 SI C N W P C I + P NG + S S F C G Sbjct: 210 EPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG 269 Query: 2749 FMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG---QVIGENYGYRDTVVYQCNP 2805 F++ G +C + W E E + C P +++ Q +N+ V Y C P Sbjct: 270 FVMKGPRRVKCQALNKW-EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEP 328 Query: 2806 GFRLIGSSVRICQQDHNWSGQLPSCVPVSC-GHPGSPIYGRT-SGNGFNFNDVVTFSCNI 2863 G+ L G++ C +WS P+C SC G + GR V F C+ Sbjct: 329 GYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDE 388 Query: 2864 GYLMQGPTKAQC---QANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVF 2920 G+ ++G + + C W+ P+C+ + C P + N + K F +G V Sbjct: 389 GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGK-PLEVFPFGKTVN 447 Query: 2921 YDCNP------GYFLFGSSVLIC----QPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK 2970 Y C+P + L G S + C Q NG W P P C ++ GH P + + + K Sbjct: 448 YTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAPDHFLFAKLK 505 Query: 2971 -------YTFGSTVHYSCTGKRSLLGQS-SRTCQLNGHWSGSQPHCSGDATGTCGDPGTP 3022 + G+++ Y C + G+ S TC N WS + C +C P P Sbjct: 506 TQTNASDFPIGTSLKYEC--RPEYYGRPFSITCLDNLVWSSPKDVCK---RKSCKTPPDP 560 Query: 3023 GHGS-RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS---WTGRQPECKAVQCGNPG 3078 +G ++ + S + Y+C TG+ L G C+ +G+ W+ + P C+ + CG P Sbjct: 561 VNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPP 620 Query: 3079 TTANGKVFRIDGTTF--SSSVIYSCMEG------YILSGPSVRQCTAN----GTWSGTLP 3126 T ANG + F S V Y C G + L G CT+N G WSG P Sbjct: 621 TIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAP 680 Query: 3127 NCTIISCGDPGIPANGLRYGDD---YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSG 3183 C I + P NG+ D+ + + + V + CQPG+ M+ G R C W Sbjct: 681 QCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMK--GPRRVKCQALNKWEP 738 Query: 3184 VMPTCRAVTCPTPPQISNG---RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3240 +P+C V C PP + + + + NF G + Y C PGY+L A + C G WS Sbjct: 739 ELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797 Query: 3241 GEVPQCLPKFCGDPGIPAQGKREGKSFIYQ------SEVSFSCNFPFILVGSSTRICQAD 3294 P C K C D G+ ++ ++V F C+ F L GSS C Sbjct: 798 PAAPTCEVKSCDD----FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 853 Query: 3295 G---TWSGSSPHCIEPTQTSCENPGVPRHGSQNN------TFGFQVGSVVQFHCKKGHL- 3344 G W+ S P C Q C +P V +G FG V H +G Sbjct: 854 GMESLWNSSVPVC---EQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSF 910 Query: 3345 -LQGSTTRTCLPDL----TWSGIQPEC-IPHSCKQPETPAHANVV----GMDLPSHGYTL 3394 L G +T C D WS P C I C+ P+ A + D P G +L Sbjct: 911 DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI-GTSL 969 Query: 3395 IYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3437 Y C+P ++ G C + W+ +C+ S DP Sbjct: 970 KYECRPEYY--GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDP 1010 Score = 209 bits (533), Expect = 3e-53 Identities = 241/937 (25%), Positives = 355/937 (37%), Gaps = 198/937 (21%) Query: 2355 CQPPPPVPNAEIL-TEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413 C PP + N + + T + F G ++ Y+C G R + ++ G P Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLG----------SRGRKVFELVGEP---S 1112 Query: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK--EFDV 2471 + C +N+ D G+ P PN C +VE G ++ F + EF Sbjct: 1113 IYCTSND---DQVGIWSGPAPQCIIPN--KCT-PPNVENGILVSDNRSLFSLNEVVEFRC 1166 Query: 2472 LQ--VYDGP--------NIQSPVLISLS-----------GDYSSAFNIT-SNGHEVFLQW 2509 V GP N P L S S G+++ + S G EVF + Sbjct: 1167 QPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVF--Y 1224 Query: 2510 SADHGNNKKGFRIRYIAFYCS-----TPESP--------------PHGYIISQTGGQLNS 2550 S + G + +G + +C+ +PE+P PHG ++ QL + Sbjct: 1225 SCEPGYDLRGAA----SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGA 1280 Query: 2551 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNG---GILTTD 2607 V + CD GFRL G S + C W+ VP C+ I C P A NG G + D Sbjct: 1281 KVSFVCDEGFRLKGSSVSHCVLVGMR-SLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGD 1339 Query: 2608 YLVGTRVTYFCND----GYRLSSKELTTAVCQSD----GTWSN------------HNKTP 2647 G ++Y C+ G + +T C SD G WS+ H KTP Sbjct: 1340 IPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTP 1399 Query: 2648 RCVVVTCPSI--NSF------------------------ILEHGRWRIV----------- 2670 P+I N F LE+ W V Sbjct: 1400 EQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGP 1459 Query: 2671 -----NGSHY-----EYKTKVVFSCDPGYHGLGPASIECLPNGT-WSWRNERPYCQIISC 2719 NG + ++ + V +SC+ G+ +G S CL +G +W + P C+IISC Sbjct: 1460 PPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISC 1519 Query: 2720 GELPTPPNGNKIGT-QTSY--GSTAIFTCDLG------FMLVGSAVRECLSS----GLWS 2766 PT NG+ +TS+ G+ + C G F LVG C S G+WS Sbjct: 1520 EPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWS 1579 Query: 2767 ESETRCLAGH-CGIPELIVNGQVIGEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHNW 2823 RC++ + C PE+ +V G + + + ++C PGF ++GS CQ + W Sbjct: 1580 SPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRW 1639 Query: 2824 SGQLPSCVPVSCGHPGSPIYGR---TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ 2880 +LP C V C P ++G + + F+ V +SC Y ++G C Sbjct: 1640 GPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD 1698 Query: 2881 WSHPPPMCKVVNCSDPGIPANSKRESKIEHG------NFTYGTVVFYDCNPGYFLFGSSV 2934 WS P C V +C D ++ HG N G V + C+ G+ L G S Sbjct: 1699 WSPEAPRCTVKSCDD--------FLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSA 1750 Query: 2935 LICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSGEKY---TFGSTVHYSCTGKR--- 2985 C G W+ +P C I C +P N +G + +G + Y+C Sbjct: 1751 SHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRG 1810 Query: 2986 ---SLLGQSSRTC----QLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SRQESNFRTK 3035 +L+G+SS C Q NG WS P C C P +G S + Sbjct: 1811 MTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPG 1870 Query: 3036 STVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT--- 3092 T+ Y CD GY+L G C G W+ CK V C P NG ++ Sbjct: 1871 MTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFP-LFMNGISKELEMKKVYH 1929 Query: 3093 FSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129 + V C +GY L G QC A+ W L CT Sbjct: 1930 YGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCT 1966 Score = 140 bits (353), Expect = 2e-32 Identities = 326/1533 (21%), Positives = 523/1533 (34%), Gaps = 309/1533 (20%) Query: 1334 GSTIIYGCNPGYTLHGSSLLKC-MTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYP 1392 GS I Y C G+ L G S +C ++G W P C G ++G +S Sbjct: 574 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633 Query: 1393 -FPYDN--NLRCMWMIEVDPGNIVSLQFL-----AFDTEASHDILRVWDGPPENDMLLKE 1444 F Y + RC +PG+ F + ++ D + +W GP ++ + Sbjct: 634 NFHYGSVVTYRC------NPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687 Query: 1445 ISGSLIPEGIHSTLN--IVTIQFDTDF-----YISKSGFAIQFSS---------SVATAC 1488 + + GI + N + ++ +F ++ K ++ + S + C Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747 Query: 1489 RDPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1545 + P ++ R + D PG V + C+PGY+L+G + C + W P+ P C Sbjct: 748 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD---WSPAAPTCE 804 Query: 1546 APCGGNLTGS--SGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLY 1603 + G +G +L P ++ + DF+ Sbjct: 805 VKSCDDFMGQLLNGRVLFP----------------------------VNLQLGAKVDFVC 836 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1663 D L GS + +ES N+ + E F Sbjct: 837 -----DEGFQLKGSSASYCVLAGMESLWNS--------------------SVPVCEQIFC 871 Query: 1664 PGN--IMNGTRLGMD---YKLGSTVTYYCD------AGYVLQGYSTLTCIMGDDGRPGWN 1712 P I NG G + G V Y CD + L G ST+ C G W+ Sbjct: 872 PSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931 Query: 1713 RALP------SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNC-VYSIAVPKEFVVFGQFV 1765 P C AP + + ++P S+ + C P V Sbjct: 932 SPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLV 991 Query: 1766 FFQTSLHDVVE---VYDGPTQQSSLLSSLSGSHSGESLPLS--SGNQITIRFTSVGPITA 1820 + +S DV + P + ++ ++ G + S +G+++ ++ ++ Sbjct: 992 W--SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSG 1049 Query: 1821 KGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVGSSVLFDCNPG------YILH 1871 H+ + P C P G I F GS V + CN G + L Sbjct: 1050 NTAHWSTKP-PICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELV 1108 Query: 1872 GSIAIRCETVPNSLAQWNDSLPTCIVP--C------GGILTKRKGTILS----------P 1913 G +I C + + + W+ P CI+P C GIL ++ S P Sbjct: 1109 GEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQP 1168 Query: 1914 GYPEPYDNNLNC----VWKITVPEGAGI-QVQVVSFATEHNWDSLDFYDGGDNNAPRLGS 1968 G+ + C W+ +P + + Q EH D + G Sbjct: 1169 GFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQE-----VF 1223 Query: 1969 YSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE--PQTPSSGIKIGD 2026 YS L + S L+ Q D S A + SC + Q P + Sbjct: 1224 YSCEPGYDLRGAAS--LHCTPQGDWSPEA-------PRCAVKSCDDFLGQLPHGRVLFPL 1274 Query: 2027 RYMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPIC-LAQCGGAMSDFSGVILS 2084 +G VSF CD+G+ L+G S C + G WN +P+C C + +G Sbjct: 1275 NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNG--RH 1332 Query: 2085 PGFP-GNYPSSLDCTWTINLPIGFGVHLQFVN---------------FSTETIHDYLEVR 2128 G P G+ P + ++T + G+ + +S+ L VR Sbjct: 1333 TGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVR 1392 Query: 2129 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHI----------VYQA 2178 +G +T + P IP + F TSL + + F I V Sbjct: 1393 AGHCKTPEQF-PFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDN 1451 Query: 2179 YQLQSC-PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPL 2236 + +SC P P PF I D G T+++ C G+ LIG+ + TCL G + W+ Sbjct: 1452 CRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1511 Query: 2237 PRCEAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY- 2294 P CE + C T NG YS + + P G + F ++ IY Sbjct: 1512 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQL---FELVGERSIYC 1568 Query: 2295 ----DFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQI------LIKFHSDFTTSGFFV 2344 D + VW P + + ++ N+ +I+F GF + Sbjct: 1569 TSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQ---PGFVM 1625 Query: 2345 LSYHAYQL--------------RVCQPPPPVPNAE-ILTEDDEFEIGDIIRYQCLPGFTL 2389 + H Q RVCQPPP + + E L+ D F G + Y C P + L Sbjct: 1626 VGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDL 1685 Query: 2390 VGNAILTCRLGERLQMDGAP--PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCA-W 2446 G A L C Q D +P P C V + L G +L P NLQ+ A Sbjct: 1686 RGAASLHC----TPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLP------LNLQLGAKV 1735 Query: 2447 SISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVF 2506 S ++G+ + G + VL + ++S+ + Sbjct: 1736 SFVCDEGFRL-------------------KGRSASHCVLAGMKALWNSSVPVCEQ----- 1771 Query: 2507 LQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQL--NSVVRWAC----DRG- 2559 +C P + +G G + + +AC DRG Sbjct: 1772 --------------------IFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGM 1811 Query: 2560 -FRLVGKSSAVCRKSSYGYHAWDAPVPACQ---AISCGIPKAPTNG---GILTTDYLVGT 2612 F L+G+SS C G W +P P C+ +C P NG G + YL G Sbjct: 1812 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGM 1871 Query: 2613 RVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNG 2672 ++Y C+ GY L K C G WS + + V + P + I + + V Sbjct: 1872 TISYICDPGYLLVGKGF--IFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKV-- 1927 Query: 2673 SHYEYKTKVVFSCDPGYHGLGPASIECLPNGTW 2705 Y Y V C+ GY G +C + W Sbjct: 1928 --YHYGDYVTLKCEDGYTLEGSPWSQCQADDRW 1958 Score = 80.1 bits (196), Expect = 4e-14 Identities = 93/409 (22%), Positives = 153/409 (37%), Gaps = 99/409 (24%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C P EP NG I +D GSTV +SC+E + L G+ S TC ++ W P+C+ Sbjct: 1457 CGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCL-VSGNNVTWDKKAPICE 1515 Query: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 + +C P T ++ +F Y +N T+ + V+ Y T Sbjct: 1516 IISCE-----PPPTISNGDF---YSNNR------TSFHNGTVVT-----------YQCHT 1550 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 DG ++ + + S D + SS + T+ K E+E + Sbjct: 1551 GPDGEQLFELVGERSIYCTS-KDDQVGVWSSPPPRCISTN--------KCTAPEVEN-AI 1600 Query: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSN 684 PG + F+ +++RF CQ GF ++G ++ CQ N +W +P C S Sbjct: 1601 RVPGNRSF-------FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC-----SR 1648 Query: 685 FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-S 742 P +L ++ + +N + PG + S +DL GD S Sbjct: 1649 VCQPPPEILHGEHTLSHQDNFS--------PGQEVFYSCEPSYDLRGAASLHCTPQGDWS 1700 Query: 743 PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPIN 802 PE+P + + L +L L Sbjct: 1701 PEAPRCTVKSCDDFLGQLPHGRVLLPL--------------------------------- 1727 Query: 803 ARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851 N QLG+ +S +C+EGF + +G C+L K +W+ +P C Sbjct: 1728 ------NLQLGAKVSFVCDEGF-RLKGRSASHCVLAGMKALWNSSVPVC 1769 Score = 69.7 bits (169), Expect = 5e-11 Identities = 134/603 (22%), Positives = 207/603 (34%), Gaps = 149/603 (24%) Query: 640 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 699 FS +V+ F CQ GF + G + + CQ N+W +P C S P +L ++ Sbjct: 1156 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-----SRVCQPPPEILHGEHTP 1210 Query: 700 GYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 757 + +N + PG + S +DL GD SPE+P Sbjct: 1211 SHQDNFS--------PGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAP----------- 1251 Query: 758 SHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSIS 817 R ++ G+ +P F N QLG+ +S Sbjct: 1252 ----------RCAVKSCDDFLGQ------------------LPHGRVLFPLNLQLGAKVS 1283 Query: 818 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC------GAPC---GGHFSAPSGVILS 868 +C+EGF + +G+ C+L+ + +W+ +P C P G H PSG I Sbjct: 1284 FVCDEGF-RLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI-- 1340 Query: 869 PGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSP-----LLG 923 P + S C +P +TF + H SP L Sbjct: 1341 ---PYGKEISYTC------DPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSV 1391 Query: 924 SYNGTQVP-QFLFSS-----SNFIYLLFTTDNSRSNNGF-----------KIHYESVTVN 966 + P QF F+S ++F + + T+ N G+ + + SV N Sbjct: 1392 RAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDN 1451 Query: 967 --TYSCLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPL 1020 SC P P +G D GSTV++SC+ G+RL C N W Sbjct: 1452 CRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1511 Query: 1021 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1080 P C+ + P TI + +FY N+ +G V + HT + + Sbjct: 1512 PICEIIS----CEPPPTISN---GDFYSNN-----RTSFHNGTVVTYQCHT-GPDGEQLF 1558 Query: 1081 LLITENGSFTQPLARLTG--SDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138 L+ E + G S PP R IS + Sbjct: 1559 ELVGERSIYCTSKDDQVGVWSSPPP--------------RCISTNKCT------------ 1592 Query: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 P + I G+R F + + + F C G+ + G+ + C GR W LP C Sbjct: 1593 -APEVENAIRVPGNRSFFT--LTEIIRFRCQPGFVMVGSHTVQCQTNGR--WGPKLPHCS 1647 Query: 1199 AEC 1201 C Sbjct: 1648 RVC 1650 Score = 69.3 bits (168), Expect = 7e-11 Identities = 134/623 (21%), Positives = 213/623 (34%), Gaps = 134/623 (21%) Query: 640 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPE 699 FS +V+ F CQ GF + G + + CQ N+W +P C C P VL + + Sbjct: 706 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC-----QPPPDVLHAERTQ 760 Query: 700 GYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVKDGD-SPESPILGTFTGAEVP 757 +N + PG + S +DL GD SP +P + + Sbjct: 761 RDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 812 Query: 758 SHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFGHNE--------------C 794 L N +L +++F D +G + +Y E C Sbjct: 813 GQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFC 871 Query: 795 PDPGIPINARRFG---DNFQLGSSISVICEEG-----FIKTQGTETITCIL-MDGKVMWS 845 P P + N R G + F G +++ C+ G TI C G +WS Sbjct: 872 PSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931 Query: 846 GLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN 905 P+CG GH A P H + F + +T+ N Sbjct: 932 SPAPRCGIL--GHCQA---------------------------PDHFL---FAKLKTQTN 959 Query: 906 YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTV 965 + G +L Y G FS + L++++ Sbjct: 960 ASDFPI--GTSLKYECRPEYYGRP-----FSITCLDNLVWSSPKD-------------VC 999 Query: 966 NTYSCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNHWWSHPLP 1021 SC P PV+G + D +GS +++SC +G+RL S E +L WS P Sbjct: 1000 KRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPP 1059 Query: 1022 TCDAL-CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDV-THGKGV--QFNFHTFHLEDH 1077 C + CG +G +S F+ S+ T+ ++ + G+ V + + + Sbjct: 1060 ICQRIPCGLPPTIANGDFISTNRENFHYGSV-VTYRCNLGSRGRKVFELVGEPSIYCTSN 1118 Query: 1078 HDYLLITENGSFTQPLARLTGSDLPPTINAGLYGN-------------FRAQLRFI--SD 1122 D + I S P + PP + G+ + FR Q F+ Sbjct: 1119 DDQVGI---WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP 1175 Query: 1123 FSISYEGFNITFSEYN--LEPCEDPGIPQYGSRIGF---NFGIGDTLTFSCSSGYRLEGT 1177 + + N E C+ P +G NF G + +SC GY L G Sbjct: 1176 RRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGA 1235 Query: 1178 SEIICLGGGRRVWSAPLPRCVAE 1200 + + C G WS PRC + Sbjct: 1236 ASLHCTPQGD--WSPEAPRCAVK 1256 Score = 65.9 bits (159), Expect = 7e-10 Identities = 203/866 (23%), Positives = 304/866 (35%), Gaps = 179/866 (20%) Query: 654 FELIGEKSIVC----QENNQWSANIPIC------------IFPCLSNFTA----PMGTVL 693 F+LIGE +I C Q N WS+ P C +F L T P+GT L Sbjct: 910 FDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSL 969 Query: 694 SPDY-PEGYGN--NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILG- 749 + PE YG ++ C+ ++ S D K +P P+ G Sbjct: 970 KYECRPEYYGRPFSITCLDNLV---------------WSSPKDVCKRKSCKTPPDPVNGM 1014 Query: 750 --TFTGAEVPSHLT---SNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP---- 800 T +V S + + H L A+ +SG + + P G+P Sbjct: 1015 VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPC-GLPPTIA 1073 Query: 801 ----INARRFGDNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPK 850 I+ R +NF GS ++ C G + G +I C D +V +WSG P+ Sbjct: 1074 NGDFISTNR--ENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1131 Query: 851 CGAP--CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDV 908 C P C + +G+++S + SLN +PG +K LN Sbjct: 1132 CIIPNKCTPP-NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 1187 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGF-KIHY------- 960 E+ + P +G P + S + ++ + G +H Sbjct: 1188 PELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWS 1247 Query: 961 -ESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 1014 E+ SC D G HGR + + +G+ VSF CD G+RL S +L Sbjct: 1248 PEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS 1307 Query: 1015 WWSHPLPTCD--------ALCGGDVRG-PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1065 W++ +P C+ A+ G G PSG I P ++T D +G+ Sbjct: 1308 LWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDI---------PYGKEISYTCDPHPDRGM 1358 Query: 1066 QFNF---HTFHL-EDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFIS 1121 FN T D H NG ++ P R S F + I+ Sbjct: 1359 TFNLIGESTIRCTSDPHG------NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPIN 1412 Query: 1122 DF------SISYEG----FNITFSEYNLE--------------PCEDPGIPQYGS-RIGF 1156 DF S++YE F FS LE C P P G I Sbjct: 1413 DFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINT 1472 Query: 1157 NFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-VAECGASATNNEGILLS 1214 + G T+ +SC+ G+RL G+ CL G V W P C + C T + G S Sbjct: 1473 DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYS 1532 Query: 1215 PNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGAS 1274 N ++ N Y Q G + F L G+ KD +G ++ Sbjct: 1533 -NNRTSFHNGTVVTY--QCHTGPD---GEQLFELV-GERSIYCTSKDDQ---VGVWSSPP 1582 Query: 1275 MRGL-----TLSSTSNQLWLEFNSDTEGTDE--------GFQLVYTSF-----------E 1310 R + T N + + N E GF +V + + Sbjct: 1583 PRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPK 1642 Query: 1311 LSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWD 1364 L HC P I + +S Q +F+ G + Y C P Y L G++ L C + W Sbjct: 1643 LPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCT--PQGDWS 1700 Query: 1365 YPLPSCIAECGGRFKGE-SSGRILSP 1389 P C + F G+ GR+L P Sbjct: 1701 PEAPRCTVKSCDDFLGQLPHGRVLLP 1726 Score = 65.1 bits (157), Expect = 1e-09 Identities = 152/670 (22%), Positives = 244/670 (36%), Gaps = 117/670 (17%) Query: 808 DNFQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSGLIPKCGAP--CGGHF 859 +NF GS ++ C G + G +I C D +V +WSG P+C P C Sbjct: 183 ENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP- 241 Query: 860 SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIK-------ITFERFQTELNYDVLEVH 912 + +G+++S + SLN +PG +K +++ EL Sbjct: 242 NVENGILVSDNRSLF---SLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298 Query: 913 DGPNLLSP--LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 970 P++L + Q +F S Y L + R + T SC Sbjct: 299 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 358 Query: 971 LD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 1025 D G ++GR + + +G+ V F CD G++L C W+ +P C+ Sbjct: 359 DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ 418 Query: 1026 L-CGGDVRGPSGTILSPGYP-EFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1083 + C P+G G P E +P +T D +G F+ LI Sbjct: 419 IFCPSPPVIPNGR--HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD-------------LI 463 Query: 1084 TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFI----------SDF----SISYE- 1128 E+ + G P G+ G+ +A F+ SDF S+ YE Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523 Query: 1129 -------GFNITFSEYNL-----------EPCEDPGIPQYGS-RIGFNFGIGDTLTFSCS 1169 F+IT + NL + C+ P P G + + +G + +SC+ Sbjct: 524 RPEYYGRPFSITCLD-NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCT 582 Query: 1170 SGYRLEGTSEIIC-LGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHE- 1226 +G+RL G S C L G WS P C CG T G +S N EN H Sbjct: 583 TGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNR----ENFHYG 638 Query: 1227 CIYSIQVQAGKGINISARTFHL---------AQGDVLKIYDGKDKTTHLLGAFTGASMRG 1277 + + + G G + F L + D + I+ G + T ++ Sbjct: 639 SVVTYRCNPGSG---GRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVEN 695 Query: 1278 LTLSSTSNQLW-----LEFNSDTEGTDEGFQLVYTSF------ELSHCE-----DPGIPQ 1321 L S + L+ +EF +G + V EL C P + Sbjct: 696 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 755 Query: 1322 FGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKG 1380 D+ +F+ G + Y C PGY L G++ ++C + W P+C + F G Sbjct: 756 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMG 813 Query: 1381 E-SSGRILSP 1389 + +GR+L P Sbjct: 814 QLLNGRVLFP 823 Score = 63.9 bits (154), Expect = 3e-09 Identities = 107/455 (23%), Positives = 163/455 (35%), Gaps = 100/455 (21%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C +P +P NG + GS +++SC + Y L G+ S TC I+ W + P+C Sbjct: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCI-ISGDTVIWDNETPICD 162 Query: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 C G T T+ +F ++TN+ NF + + Y Sbjct: 163 RIPC-----GLPPTITNGDF----------------ISTNRE---NFH-YGSVVTY-RCN 196 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 G GG R V + L G P + + + D+ VG + + I C Sbjct: 197 PGSGG-----RKVFE-LVGE--PSIYCTSN---------DDQVG-IWSGPAPQCIIPNKC 238 Query: 625 GDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 681 P GI D FS +V+ F CQ GF + G + + CQ N+W +P C Sbjct: 239 TPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---- 293 Query: 682 LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDG 740 S P VL + + +N + PG + S +DL G Sbjct: 294 -SRVCQPPPDVLHAERTQRDKDNFS--------PGQEVFYSCEPGYDLRGAASMRCTPQG 344 Query: 741 D-SPESPILGTFTGAEVPSHLTSNSHIL---------RLEFQADHSMSGRGFNITYNTFG 790 D SP +P + + L N +L +++F D +G + +Y Sbjct: 345 DWSPAAPTCEVKSCDDFMGQLL-NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 403 Query: 791 HNE--------------CPDPGIPINARRFG---DNFQLGSSISVICEE-----GFIKTQ 828 E CP P + N R G + F G +++ C+ Sbjct: 404 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463 Query: 829 GTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAP 862 G TI C G +WS P+CG GH AP Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGIL--GHCQAP 496 Score = 60.8 bits (146), Expect = 2e-08 Identities = 136/619 (21%), Positives = 200/619 (32%), Gaps = 134/619 (21%) Query: 648 FECQFGFELIGEKSIVCQ---ENNQWSANIPIC--IFPCLSNFTAPMGTVLSPD---YPE 699 F C GF+L G + C + W++++P+C IF C S P G +P Sbjct: 384 FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF-CPSPPVIPNGRHTGKPLEVFPF 442 Query: 700 GYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD---SPESPILGTFTGAEV 756 G N C DP SF D ES + G+ S +P G + Sbjct: 443 GKTVNYTC------DPHPDRGTSF-DLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495 Query: 757 PSHL--------TSNSHI---LRLEFQADHSMSGRGFNITY----------NTFGHNECP 795 P H T+ S L+++ GR F+IT + C Sbjct: 496 PDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCK 555 Query: 796 DPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA- 853 P P+N + Q+GS I+ C G + G + CIL WS P C Sbjct: 556 TPPDPVNGMVHVITDIQVGSRINYSCTTGH-RLIGHSSAECILSGNAAHWSTKPPICQRI 614 Query: 854 PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDV 908 PCG + +G +S ++ S+ PG + FE N D Sbjct: 615 PCGLPPTIANGDFISTNRENFHYGSVV---TYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQ-FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESV 963 + + GP + V L S + ++ L R GF + + Sbjct: 672 VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731 Query: 964 TVNTYS---------CLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCE 1011 +N + C P +H R D FS G V +SC+ GY L + C Sbjct: 732 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCT 791 Query: 1012 KNHWWSHPLPTCDALCGGDVRGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF 1069 WS PTC+ D G +G +L +P +L VD +G Q Sbjct: 792 PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ--- 841 Query: 1070 HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG 1129 L GS + AG+ + + + Sbjct: 842 --------------------------LKGSSASYCVLAGMESLWNSSVPVCEQIF----- 870 Query: 1130 FNITFSEYNLEPCEDPGIPQYGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEI 1180 C P + G G F G + ++C + + L G S I Sbjct: 871 ------------CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTI 918 Query: 1181 ICLGG--GRRVWSAPLPRC 1197 C G VWS+P PRC Sbjct: 919 RCTSDPQGNGVWSSPAPRC 937 Score = 60.5 bits (145), Expect = 3e-08 Identities = 132/647 (20%), Positives = 223/647 (34%), Gaps = 127/647 (19%) Query: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIA 1372 C +P P G +G GS I Y C GY L GSS C+ +G+ WD P C Sbjct: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163 Query: 1373 ECGGRFKGESSGRILSPGYP-FPYDN--NLRCMWMIEVDPGNIVSLQFL-----AFDTEA 1424 G ++G +S F Y + RC +PG+ F + + Sbjct: 164 IPCGLPPTITNGDFISTNRENFHYGSVVTYRC------NPGSGGRKVFELVGEPSIYCTS 217 Query: 1425 SHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLN--IVTIQFDTDF-----YISKSGFA 1477 + D + +W GP ++ + + + GI + N + ++ +F ++ K Sbjct: 218 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277 Query: 1478 IQFSS---------SVATACRDPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEER 1525 ++ + S + C+ P ++ R + D PG V + C+PGY+L+G Sbjct: 278 VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS 337 Query: 1526 ITCIQVENRYFWQPSPPVCIAPCGGNLTGS--SGFILSPNFPHPYPHSRDCDWTITVNAD 1583 + C + W P+ P C + G +G +L P Sbjct: 338 MRCTPQGD---WSPAAPTCEVKSCDDFMGQLLNGRVLFP--------------------- 373 Query: 1584 YVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS 1643 ++ + DF+ D L GS + +ES N+ Sbjct: 374 -------VNLQLGAKVDFVC-----DEGFQLKGSSASYCVLAGMESLWNS---------- 411 Query: 1644 VSYTGFHLEYKAKLRESCFDPGN--IMNGTRLGMD---YKLGSTVTYYCD------AGYV 1692 + E F P I NG G + G TV Y CD + Sbjct: 412 ----------SVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 461 Query: 1693 LQGYSTLTCIMGDDGRPGWNRALP------SCHAPCGSRSTGSEGTVLSPNYPKNYSVGH 1746 L G ST+ C G W+ P C AP + + ++P S+ + Sbjct: 462 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY 521 Query: 1747 NC-VYSIAVPKEFVVFGQFVFFQTSLHDVVE---VYDGPTQQSSLLSSLSGSHSGESLPL 1802 C P V+ +S DV + P + ++ ++ G + Sbjct: 522 ECRPEYYGRPFSITCLDNLVW--SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 579 Query: 1803 S--SGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVG 1857 S +G+++ ++ ++ H+ + P C P G I F G Sbjct: 580 SCTTGHRLIGHSSAECILSGNAAHWSTKP-PICQRIPCGLPPTIANGDFISTNRENFHYG 638 Query: 1858 SSVLFDCNPG------YILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1898 S V + CNPG + L G +I C + + + W+ P CI+P Sbjct: 639 SVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685 Score = 60.5 bits (145), Expect = 3e-08 Identities = 142/626 (22%), Positives = 212/626 (33%), Gaps = 125/626 (19%) Query: 137 SCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 SC P P G+++ T VG +I YSC TG+ L GH CI S N A W PIC Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECIL-SGNAAHWSTKPPIC 611 Query: 196 RAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIF-----TDFQMEE 250 + CG ++G S + N +H + T+ PG +F Sbjct: 612 Q-RIPCGLPPTIANGDFISTNREN-FHYGSVVTYR--CNPGSGGRKVFELVGEPSIYCTS 667 Query: 251 KYDYLEIEGSEPPTIWLSGMNIPPP------IISNKNWLRLHFVTDSNHRYRGFSAPYQG 304 D + I P + PP + N++ L+ V + F Sbjct: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE-------FRCQPGF 720 Query: 305 SSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVT----- 359 L + V P DV + T S Q V + Sbjct: 721 VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 780 Query: 360 SLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFK-SRG 418 LR + T + SP A T + Q+ + L V ++ +DF G Sbjct: 781 DLRGAASMRCTPQGDWSP-AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEG 839 Query: 419 FKLFPGKDNSNKFSILNEGGIKTASN---------LCPDPGEPENGKRIGSD---FSLGS 466 F+L K +S + +L G+++ N CP P NG+ G F G Sbjct: 840 FQL---KGSSASYCVL--AGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGK 894 Query: 467 TVQFSCD------EDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFT 520 V ++CD + L G +I C + WS P C + + Q P Sbjct: 895 AVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGIL---GHCQAPDHFLF 951 Query: 521 SPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQV 580 + + +NA + T++ + F ++T D P+ V + Sbjct: 952 A---KLKTQTNASDFPIGTSLKYECRPEYYGRPF-------SITCLDNLVWSSPKDVCKR 1001 Query: 581 LTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK----------------------- 617 + PD + M +H+ TD VGS ++NY Sbjct: 1002 KSCKTPPDPVNGM-----VHVITDIQVGS---RINYSCTTGHRLIGHSSAECILSGNTAH 1053 Query: 618 ------EIEKESCGDPGTPLYGIREGDGFS-NRD------VLRFECQFG------FELIG 658 ++ CG P T I GD S NR+ V+ + C G FEL+G Sbjct: 1054 WSTKPPICQRIPCGLPPT----IANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVG 1109 Query: 659 EKSIVCQENNQ----WSANIPICIFP 680 E SI C N+ WS P CI P Sbjct: 1110 EPSIYCTSNDDQVGIWSGPAPQCIIP 1135 Score = 60.1 bits (144), Expect = 4e-08 Identities = 104/479 (21%), Positives = 156/479 (32%), Gaps = 110/479 (22%) Query: 769 LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINAR-RFGDNFQLGSSIS 817 L ++ SGR F+I + C +P P+N Q GS I Sbjct: 69 LNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIK 128 Query: 818 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG-APCGGHFSAPSGVILSPGWPGYYK 876 C +G+ + G+ + TCI+ V+W P C PCG + +G +S ++ Sbjct: 129 YSCTKGY-RLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHY 187 Query: 877 DSLNCEWVIEAEPGHSIKITFE-----RFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVP 931 S+ PG + FE N D + + GP +P N P Sbjct: 188 GSV---VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP---APQCIIPNKCTPP 241 Query: 932 Q----FLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 974 L S + ++ L R GF + + +N + C P Sbjct: 242 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 301 Query: 975 IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 1031 +H R D FS G V +SC+ GY L + C WS PTC+ D Sbjct: 302 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDF 361 Query: 1032 RGP--SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1089 G +G +L +P +L VD +G Q Sbjct: 362 MGQLLNGRVL-------FPVNLQLGAKVDFVCDEGFQ----------------------- 391 Query: 1090 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1149 L GS + AG+ + + + C P + Sbjct: 392 ------LKGSSASYCVLAGMESLWNSSVPVCEQIF-----------------CPSPPVIP 428 Query: 1150 YGSRIGFN---FGIGDTLTFSC------SSGYRLEGTSEIICLGG--GRRVWSAPLPRC 1197 G G F G T+ ++C + + L G S I C G VWS+P PRC Sbjct: 429 NGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 487 Score = 59.7 bits (143), Expect = 5e-08 Identities = 139/652 (21%), Positives = 216/652 (33%), Gaps = 142/652 (21%) Query: 1142 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC-V 1198 C +P P G + G + +SC+ GYRL G+S C + G +W P C Sbjct: 104 CRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDR 163 Query: 1199 AECGASATNNEGILLSPNYPLNYENNH-ECIYSIQVQAGKGINISARTFHL--------- 1248 CG T G +S N EN H + + + G G + F L Sbjct: 164 IPCGLPPTITNGDFIS----TNRENFHYGSVVTYRCNPGSG---GRKVFELVGEPSIYCT 216 Query: 1249 AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLW-----LEFNSDTEGTDEGFQ 1303 + D + I+ G + T ++ L S + L+ +EF +G + Sbjct: 217 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 276 Query: 1304 LVYTSF------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSS 1351 V EL C P + D+ +F+ G + Y C PGY L G++ Sbjct: 277 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 336 Query: 1352 LLKCMTGERRAWDYPLPSCIAECGGRFKGE-SSGRILSPGYPFPYDNNLRCMWMIEVDPG 1410 ++C + W P+C + F G+ +GR+L FP + L D G Sbjct: 337 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-----FPVNLQLGAKVDFVCDEG 389 Query: 1411 NIVSLQFLAFDTEASHDIL----RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFD 1466 F + AS+ +L +W+ + S +IP G H+ + F Sbjct: 390 ------FQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF- 442 Query: 1467 TDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDP------GYEL 1520 G TV + CDP ++L Sbjct: 443 ----------------------------------------GKTVNYTCDPHPDRGTSFDL 462 Query: 1521 QGEERITCI-QVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPN---FPHPYPHSRDCDW 1576 GE I C + W P C G G +P+ F + D+ Sbjct: 463 IGESTIRCTSDPQGNGVWSSPAPRC---------GILGHCQAPDHFLFAKLKTQTNASDF 513 Query: 1577 TITVNADYVISLAFIS--FSIEPNYDFLY-----------IYDGPDSNSPLIGSFQDSKL 1623 I + Y + FSI + ++ PD + ++ D ++ Sbjct: 514 PIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 573 Query: 1624 PERIESSSNTMH-LAFRSDGSVSYTGFHLEYKAK----LRESCFDPGNIMNGTRLGM--- 1675 RI S T H L S +G + K R C P I NG + Sbjct: 574 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633 Query: 1676 DYKLGSTVTYYCDAG------YVLQGYSTLTCIMGDDGRPGWNRALPSCHAP 1721 ++ GS VTY C+ G + L G ++ C DD W+ P C P Sbjct: 634 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 685 Score = 49.3 bits (116), Expect = 7e-05 Identities = 70/277 (25%), Positives = 98/277 (35%), Gaps = 34/277 (12%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C P +P NG + +D +GS + +SC + L G S C A WS P+C+ Sbjct: 1004 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNT-AHWSTKPPICQ 1062 Query: 505 VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 562 CG +G F S N F Y S V+T N + FE Y T Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNLGSRGRKVFELVGEPSIYCT 1116 Query: 563 LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 612 G P + P+ ++VS + ++ + E GF Sbjct: 1117 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1176 Query: 613 -----KVNYKEIEKESCGDPGTPLYGIREG-------DGFSNRDVLRFECQFGFELIGEK 660 +N E E SC P I G D FS + + C+ G++L G Sbjct: 1177 RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1236 Query: 661 SIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSP 695 S+ C WS P C +F P G VL P Sbjct: 1237 SLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFP 1273 Score = 48.1 bits (113), Expect = 2e-04 Identities = 140/645 (21%), Positives = 212/645 (32%), Gaps = 136/645 (21%) Query: 654 FELIGEKSIVCQE----NNQWSANIPICI-------------FPCLS------NFTAPMG 690 F LIGE +I C N WS+ P C FP S +F P+G Sbjct: 1360 FNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVG 1419 Query: 691 TVLSPDYPEGYGNNL-------NCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSP 743 T L+ + GY + N +W+ + D R K P Sbjct: 1420 TSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRR-------------------KSCGPP 1460 Query: 744 ESPILGTF---TGAEVPSHLT-SNSHILRLEFQADHSMSGRGFNITYNTFGHN----ECP 795 P G T + S + S + RL + G N+T++ C Sbjct: 1461 PEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE 1520 Query: 796 DPGIPINARRFGDN---FQLGSSISVICEEG-----FIKTQGTETITCILMDGKV-MWSG 846 P N + +N F G+ ++ C G + G +I C D +V +WS Sbjct: 1521 PPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSS 1580 Query: 847 LIPKCGAPCGGHFSAPSGVILSPGWPGYYKDS----LNCEWVIEAEPGHSIKI-TFERFQ 901 P+C + I PG ++ + C+ H+++ T R+ Sbjct: 1581 PPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWG 1640 Query: 902 TELNYDVLEVHDGPNLL--SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIH 959 +L + P +L L + Q +F S Y L + Sbjct: 1641 PKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWS 1700 Query: 960 YESVTVNTYSCLD-PGIPVHGR-RYGHDFSIGSTVSFSCDSGYRL---SHEEPLLCEKNH 1014 E+ SC D G HGR + +G+ VSF CD G+RL S +L Sbjct: 1701 PEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKA 1760 Query: 1015 WWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHL 1074 W+ +P C+ I P P T D+ +GK + + T H Sbjct: 1761 LWNSSVPVCE------------QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDT-HP 1807 Query: 1075 EDHHDYLLITE-----------NGSFTQPLARL-----TGSDLPPTINAGLYGNFRAQLR 1118 + + LI E NG ++ P R PP I G Y L Sbjct: 1808 DRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL- 1866 Query: 1119 FISDFSISY---EGFNITFSEYNLEPCEDPGI----PQYGSRIGFNFGI----------- 1160 ++ +ISY G+ + + C D GI Y + +F + Sbjct: 1867 YLPGMTISYICDPGYLLVGKGFIF--CTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEM 1924 Query: 1161 ------GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1199 GD +T C GY LEG+ C R W PL +C + Sbjct: 1925 KKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDR--WDPPLAKCTS 1967 Score = 47.0 bits (110), Expect = 3e-04 Identities = 68/277 (24%), Positives = 99/277 (35%), Gaps = 34/277 (12%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C P +P NG + +D +GS + +SC + L G S C A WS P+C+ Sbjct: 554 CKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNA-AHWSTKPPICQ 612 Query: 505 VKTCGSNLQGPSGTFTSPNFP-FQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDT 562 CG +G F S N F Y S V+T N + FE Y T Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGS------VVTYRCNPGSGGRKVFELVGEPSIYCT 666 Query: 563 LTIGDGGEVGDPRTVLQVLTGSFVPD----LIVSMSSQMWLHLQTDESVGSVGF------ 612 G P + P+ ++VS + ++ + E GF Sbjct: 667 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 726 Query: 613 -----KVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFECQFGFELIGEK 660 +N E E SC P + R+ D FS + + C+ G++L G Sbjct: 727 RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 786 Query: 661 SIVCQENNQWSANIPICIFPCLSNFTAPM--GTVLSP 695 S+ C WS P C +F + G VL P Sbjct: 787 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 823 Score = 46.6 bits (109), Expect = 5e-04 Identities = 25/66 (37%), Positives = 34/66 (51%), Gaps = 2/66 (3%) Query: 131 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 189 + + SC NP P G+++ + G +I+YSC GY L G TCI S +T WD Sbjct: 97 DRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCII-SGDTVIWD 155 Query: 190 FPVPIC 195 PIC Sbjct: 156 NETPIC 161 Score = 46.6 bits (109), Expect = 5e-04 Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%) Query: 131 EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 189 + + SCG P P G+++ T G + YSC G+ L G P TC+ S N +WD Sbjct: 1450 DNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV-SGNNVTWD 1508 Query: 190 FPVPIC 195 PIC Sbjct: 1509 KKAPIC 1514 Score = 45.1 bits (105), Expect = 0.001 Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 2/79 (2%) Query: 1487 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC- 1544 +CR+P P+NG + G + G + + C GY L G TCI + W P+C Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162 Query: 1545 IAPCGGNLTGSSGFILSPN 1563 PCG T ++G +S N Sbjct: 163 RIPCGLPPTITNGDFISTN 181 Score = 44.3 bits (103), Expect = 0.002 Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Query: 436 EGGIKTASNLCPDPGEPENGKRIGS---DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 492 E + + S +C P E +G+ S +FS G V +SC+ Y L+GA S+ C + Sbjct: 1187 EPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD- 1245 Query: 493 FAAWSDHRPVCKVKTCGSNL-QGPSGTFTSP 522 WS P C VK+C L Q P G P Sbjct: 1246 ---WSPEAPRCAVKSCDDFLGQLPHGRVLFP 1273 Score = 44.3 bits (103), Expect = 0.002 Identities = 83/385 (21%), Positives = 138/385 (35%), Gaps = 90/385 (23%) Query: 154 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGII- 212 F VG + Y C GY ++C+ N V W CR + +CG +G++ Sbjct: 1416 FPVGTSLNYECRPGYFGKMF-SISCLENLV----WSSVEDNCRRK-SCGPPPEPFNGMVH 1469 Query: 213 --SSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGM 270 + F + + + + + ++ P T + + ++K EI EPP Sbjct: 1470 INTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPP------- 1522 Query: 271 NIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGELEEHNRTTTGAIAV 330 P ISN ++ SN+R + + +T+ TG E G ++ Sbjct: 1523 ----PTISNGDFY-------SNNR-----TSFHNGTVVTYQCHTGPDGEQLFELVGERSI 1566 Query: 331 ASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTSKDGLSPHP---ADTQSTRR 387 T S++ +V V S SP P + + T Sbjct: 1567 YCT-----------------SKDDQVGVWS---------------SPPPRCISTNKCTAP 1594 Query: 388 RPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPG--KDNSNKFSILNEGG----IKT 441 +A ++ + +T ++ F+ PG S+ G + Sbjct: 1595 EVENAIRVPGNRSFFTLTEIIR---------FRCQPGFVMVGSHTVQCQTNGRWGPKLPH 1645 Query: 442 ASNLCPDPGEPENGKRIGS---DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSD 498 S +C P E +G+ S +FS G V +SC+ Y L+GA S+ C + WS Sbjct: 1646 CSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGD----WSP 1701 Query: 499 HRPVCKVKTCGSNL-QGPSGTFTSP 522 P C VK+C L Q P G P Sbjct: 1702 EAPRCTVKSCDDFLGQLPHGRVLLP 1726 Score = 43.9 bits (102), Expect = 0.003 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 7/76 (9%) Query: 436 EGGIKTASNLC---PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEV 492 E + + S +C PD E +R +FS G V +SC+ Y L+GA S+ C + Sbjct: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD- 345 Query: 493 FAAWSDHRPVCKVKTC 508 WS P C+VK+C Sbjct: 346 ---WSPAAPTCEVKSC 358 Score = 37.0 bits (84), Expect = 0.36 Identities = 23/66 (34%), Positives = 28/66 (42%), Gaps = 7/66 (10%) Query: 446 CPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502 CP P + +NG IG SL G T+ + CD Y+L G I C WS Sbjct: 1848 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTD----QGIWSQLDHY 1903 Query: 503 CKVKTC 508 CK C Sbjct: 1904 CKEVNC 1909 Score = 36.6 bits (83), Expect = 0.47 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 19/113 (16%) Query: 402 AVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPD--------PGEPE 453 +VVT+R + SRG K+F + + N+ + S P P E Sbjct: 1089 SVVTYRC----NLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 1144 Query: 454 NGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 NG + + FSL V+F C +V++G + + CQ + + W P C Sbjct: 1145 NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 1193 Score = 35.0 bits (79), Expect = 1.4 Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 24/105 (22%) Query: 419 FKLFPGKDNSNKFSILNEGGIKTASN--------------LCPD---PGEPENGKRIGSD 461 ++ PG F ++ E I SN + P+ P ENG + + Sbjct: 193 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252 Query: 462 ---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 FSL V+F C +V++G + + CQ + + W P C Sbjct: 253 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK----WEPELPSC 293 Score = 33.9 bits (76), Expect = 3.0 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%) Query: 461 DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 508 + LG+ V F CDE + L+G + C +A + A W+ PVC+ C Sbjct: 1728 NLQLGAKVSFVCDEGFRLKGRSASHCV-LAGMKALWNSSVPVCEQIFC 1774 Score = 33.5 bits (75), Expect = 4.0 Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 2/48 (4%) Query: 2028 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM 2075 Y GD V+ +C+ GY+L+G C RW+ P+ C ++ A+ Sbjct: 1928 YHYGDYVTLKCEDGYTLEGSPWSQCQADD--RWDPPLAKCTSRTHDAL 1973 Score = 33.1 bits (74), Expect = 5.2 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%) Query: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184 E + SC PP VL+ R F G ++ YSC GY L G + C Sbjct: 287 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 343 Query: 185 TASWDFPVPICR---AEDACGGTMRG 207 W P C +D G + G Sbjct: 344 -GDWSPAAPTCEVKSCDDFMGQLLNG 368 Score = 33.1 bits (74), Expect = 5.2 Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 14/86 (16%) Query: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184 E + SC PP VL+ R F G ++ YSC GY L G + C Sbjct: 737 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQ--- 793 Query: 185 TASWDFPVPICR---AEDACGGTMRG 207 W P C +D G + G Sbjct: 794 -GDWSPAAPTCEVKSCDDFMGQLLNG 818 Score = 32.7 bits (73), Expect = 6.8 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%) Query: 134 QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 184 Q CG P G T F G + Y C G + L G P + C +N Sbjct: 612 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671 Query: 185 TASWDFPVPICRAEDAC 201 W P P C + C Sbjct: 672 VGIWSGPAPQCIIPNKC 688 Score = 32.7 bits (73), Expect = 6.8 Identities = 21/77 (27%), Positives = 26/77 (33%), Gaps = 9/77 (11%) Query: 134 QSSSCGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVN 184 Q CG P G T F G + Y C G + L G P + C +N Sbjct: 1062 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1121 Query: 185 TASWDFPVPICRAEDAC 201 W P P C + C Sbjct: 1122 VGIWSGPAPQCIIPNKC 1138 Score = 32.3 bits (72), Expect = 8.9 Identities = 20/73 (27%), Positives = 25/73 (34%), Gaps = 9/73 (12%) Query: 138 CGNPGVPPKGVLYGTR---FDVGDKIRYSCVTG------YILDGHPQLTCIANSVNTASW 188 CG P G T F G + Y C G + L G P + C +N W Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225 Query: 189 DFPVPICRAEDAC 201 P P C + C Sbjct: 226 SGPAPQCIIPNKC 238 >gi|54792123 complement component (3d/Epstein Barr virus) receptor 2 isoform 1 [Homo sapiens] Length = 1092 Score = 353 bits (905), Expect = 2e-96 Identities = 288/975 (29%), Positives = 421/975 (43%), Gaps = 106/975 (10%) Query: 2529 CSTPESPPHGYI-ISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587 C +P +G I T + +V+R++C FRL+G+ S +C WD P P C Sbjct: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82 Query: 2588 QAI----SCGIPKAPTNGGIL-TTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSN 2642 + SC P P I +T Y G VT+ C + ++ + + CQ++ W Sbjct: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNK--SVWCQANNMW-G 139 Query: 2643 HNKTPRCVVV---TCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIEC 2699 + P CV V CP++ ++ +G N V +SC+ GY +G I C Sbjct: 140 PTRLPTCVSVFPLECPALP--MIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINC 197 Query: 2700 LPNGTWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRE 2758 L +G WS P C+ C L PNG K G TA F CD G+ L G Sbjct: 198 LSSGKWS--AVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255 Query: 2759 CLSSG---LWSESETRCLAGHCGIPELIVNGQVIGE---NYGYRDTVVYQCNP------G 2806 C+ +G W++ C C P I+NG+ IG N Y V Y C+P Sbjct: 256 CVIAGQGVAWTKMPV-CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314 Query: 2807 FRLIGSSVRIC----QQDHNWSGQLPSC----VPVSCGHP----GSPIYGRTSGNGFNFN 2854 F LIG S C Q+ WSG P C V C HP G + G+ + + +N Sbjct: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQK--DRYTYN 372 Query: 2855 DVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFT 2914 D V F+C G+ ++G + +C A W P+C+ C P N ++E + F Sbjct: 373 DTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDR-HMVRFD 430 Query: 2915 YGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTF- 2973 GT + Y CNPGY L G + C G W P+P+C + C G +L+ ++ F Sbjct: 431 PGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG---RQLLTKPQHQFV 487 Query: 2974 GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQES--- 3030 V+ SC L G + CQ W C TC P +G+ S Sbjct: 488 RPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCK---EITCPPPPVIYNGAHTGSSLE 544 Query: 3031 NFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECK----AVQCGN 3076 +F +TV Y C+ G + L G C +N G+W+G P CK AVQC + Sbjct: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604 Query: 3077 PGTTANGKVFRIDGTT----FSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS 3132 ANG ++I G ++ +V + C G+ L G S +C A+ TW +P C Sbjct: 605 V-HIANG--YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGC 661 Query: 3133 CGDPGIPANGLRYGDD---YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3189 PG+ +G G + +V G V Y C PGY L G++ C +G WS P C Sbjct: 662 QSPPGL-HHGRHTGGNTVFFVSGMTVDYTCDPGYL--LVGNKSIHCMPSGNWSPSAPRCE 718 Query: 3190 AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTC--VGNGTWSGEVPQCL 3247 TC Q G+ + ++ C GY+L+ A C NG W ++P C Sbjct: 719 E-TCQHVRQSLQELPAGSRVE---LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCK 774 Query: 3248 PKFCGDPGIPAQGKREG---KSFIYQSEVSFSCNFPFILVGSSTRICQAD----GTWSGS 3300 C P + GK G ++F+Y +EVS+ C+ F L+G C++D G+WSG Sbjct: 775 VIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGP 834 Query: 3301 SPHCI-EPTQTSCENPGVPRHGSQNNT--FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL 3357 SP C+ P T C NP V +HG + N + +V C G ++ GS C D Sbjct: 835 SPQCLRSPPVTRCPNPEV-KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDN 893 Query: 3358 TWSGIQPECIPHS---CKQPETPAHANVVGMDLP--SHGYTLIYTCQPGFFLAGGTEHRV 3412 TW P CI + C P + N G ++ S G +++Y+C G+ L G + Sbjct: 894 TWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLV-GEALLL 952 Query: 3413 CRSDNTWTGKVPICE 3427 C + TW+ P C+ Sbjct: 953 CTHEGTWSQPAPHCK 967 Score = 335 bits (860), Expect = 4e-91 Identities = 286/1071 (26%), Positives = 439/1071 (40%), Gaps = 137/1071 (12%) Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQ--MDGAPPVC 2412 C PPP+ N I +G +IRY C F L+G L C +++ D P C Sbjct: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82 Query: 2413 QVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVL 2472 + Y + Y + C I V GY I Sbjct: 83 E--------------------YFNKYSS---CPEPI-VPGGYKIRG-------------- 104 Query: 2473 QVYDGPNIQSPVLISLSGDYSSAFNITSNGHE-VFLQWSADHGNNKKGFRIRYIAFYCST 2531 +P S ++ N + NG++ V+ Q + G + + C Sbjct: 105 --------STPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPA 156 Query: 2532 PESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2589 +G+ S+ G + V ++C+ G+ LVG+ C S W A P C+ Sbjct: 157 LPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSG----KWSAVPPTCEE 212 Query: 2590 ISCGIPKAPTNGGILTTDYL-VGTRVTYFCNDGYRLSSKELTTAVCQSDGT-WSNHNKTP 2647 C NG + L VG +FC++GYRL + V G W+ K P Sbjct: 213 ARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT---KMP 269 Query: 2648 RCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDP------GYHGLGPASIECLP 2701 C + CPS + +GR + ++ Y + V ++CDP + +G +++ C Sbjct: 270 VCEEIFCPSPPPIL--NGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTV 327 Query: 2702 NG--TWSWRNERPYCQI-ISCGELPTPP--NGNKIGTQT---SYGSTAIFTCDLGFMLVG 2753 + T +W P C++ S + P P G + Q +Y T IF C GF L G Sbjct: 328 DSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKG 387 Query: 2754 SAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRD---TVVYQCNPGFRLI 2810 S C + G W S C C P I+NGQ + D ++ Y CNPG+ L+ Sbjct: 388 SKQIRCNAQGTWEPSAPVC-EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLV 446 Query: 2811 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGP 2870 G C + W+ +P C +C G + + + F DV + SC GY + G Sbjct: 447 GEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQ-HQFVRPDVNS-SCGEGYKLSGS 504 Query: 2871 TKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRE-SKIEHGNFTYGTVVFYDCNPG--- 2926 +CQ W +CK + C P + N S +E +F YGT V Y CNPG Sbjct: 505 VYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLE--DFPYGTTVTYTCNPGPER 562 Query: 2927 ---YFLFGSSVLICQPN----GQWDKPLPEC----IMIDCGHPGVPPNAVLSGEK--YTF 2973 + L G S + C N G W P P C + + C H + +SG++ Y + Sbjct: 563 GVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFY 622 Query: 2974 GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESN-- 3031 TV + C +L G S C+ + W P C C P HG N Sbjct: 623 NDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKG----CQSPPGLHHGRHTGGNTV 678 Query: 3032 -FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDG 3090 F + TV Y CD GY+L G++ C+ +G+W+ P C+ C + + + Sbjct: 679 FFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEET-CQH----VRQSLQELPA 733 Query: 3091 TTFSSSVIYSCMEGYILSGPSVRQC--TANGTWSGTLPNCTIISCGDPGIPANGLRYG-- 3146 + V SC +GY L+G + + C NG W +P C +I C P + NG G Sbjct: 734 GSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMM 793 Query: 3147 -DDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN----GTWSGVMPTCR----AVTCPTPP 3197 ++++ G VSY C G+ L G + C + G+WSG P C CP P Sbjct: 794 AENFLYGNEVSYECDQGFY--LLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE 851 Query: 3198 QISNGRLEGTNFDWGFS-ISYI-CSPGYELSFPAVLTCVGNGTWSGEVPQCLPK-FCGDP 3254 +L T+ + + I Y+ C+PG+ ++ V+ C + TW VP C+ K F G P Sbjct: 852 VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCP 911 Query: 3255 GIPA--QGKREGKSFIYQS---EVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQ 3309 P G G + S + +SC+ ++LVG + +C +GTWS +PHC E Sbjct: 912 PPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNC 971 Query: 3310 TSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3360 +S + + G + +Q G+VV C+ G++L+GS C D W+ Sbjct: 972 SSPADMDGIQKGLEPRKM-YQYGAVVTLECEDGYMLEGSPQSQCQSDHQWN 1021 Score = 281 bits (718), Expect = 1e-74 Identities = 235/798 (29%), Positives = 342/798 (42%), Gaps = 107/798 (13%) Query: 2717 ISCGELPTPPNG--NKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS----GLWSESET 2770 ISCG P NG + T + G+ ++C F L+G C++ G W + Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80 Query: 2771 RC--LAGHCGIPELIVNG--QVIGEN-YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSG 2825 +C + PE IV G ++ G Y + D+V + C F + G+ CQ ++ W Sbjct: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140 Query: 2826 -QLPSCV---PVSCGHPGSPIYGRTSGNGFNFNDV-----VTFSCNIGYLMQGPTKAQCQ 2876 +LP+CV P+ C P P+ N + VT+SC GYL+ G C Sbjct: 141 TRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCL 198 Query: 2877 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2936 ++ +WS PP C+ C G N K + E G + C+ GY L G Sbjct: 199 SSGKWSAVPPTCEEARCKSLGRFPNGKVK---EPPILRVGVTANFFCDEGYRLQGPPSSR 255 Query: 2937 CQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSGE-------KYTFGSTVHYSCTGKRS 2986 C GQ W K +P C I C P PP +L+G ++GS V Y+C Sbjct: 256 CVIAGQGVAWTK-MPVCEEIFC--PSPPP--ILNGRHIGNSLANVSYGSIVTYTCDPDPE 310 Query: 2987 ------LLGQSSRTC----QLNGHWSGSQPHCSGDATGT-CGDPG--TPGHGSRQESNFR 3033 L+G+S+ C Q G WSG P C + C P S Q+ + Sbjct: 311 EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYT 370 Query: 3034 TKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGK-----VFRI 3088 TV +AC G+ L GS++ C A G+W P C+ +C P NG+ + R Sbjct: 371 YNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRF 429 Query: 3089 DGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDD 3148 D T S+ YSC GY+L G QCT+ G W+ +P C + +C G L Sbjct: 430 DPGT---SIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG--RQLLTKPQH 484 Query: 3149 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGT- 3207 V +V+ C GY +L+GS + C W + C+ +TCP PP I NG G+ Sbjct: 485 QFVRPDVNSSCGEGY--KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSS 542 Query: 3208 --NFDWGFSISYICSPG------YELSFPAVLTCVGN----GTWSGEVPQC----LPKFC 3251 +F +G +++Y C+PG + L + + C N GTWSG P C L C Sbjct: 543 LEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC 602 Query: 3252 GDPGIPAQGKREGKS--FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQ 3309 I K GK + Y V+F C F L GSS C+AD TW P C + Sbjct: 603 SHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVC----E 658 Query: 3310 TSCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECI 3367 C++P HG + NT F G V + C G+LL G+ + C+P WS P C Sbjct: 659 KGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRC- 717 Query: 3368 PHSCKQPETPAHANVVGMDLPSHGYTLIY--TCQPGFFLAGGTEHRVCR--SDNTWTGKV 3423 ET H +LP+ + +CQ G+ L G +++C+ + W K+ Sbjct: 718 ------EETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHA-YQMCQDAENGIWFKKI 770 Query: 3424 PICEAGSKILVKDPRPAL 3441 P+C K++ P P + Sbjct: 771 PLC----KVIHCHPPPVI 784 Score = 253 bits (646), Expect = 2e-66 Identities = 209/693 (30%), Positives = 291/693 (41%), Gaps = 86/693 (12%) Query: 2549 NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDY 2608 N V +AC GF L G C W+ P C+ C P NG Sbjct: 372 NDTVIFACMFGFTLKGSKQIRCNAQG----TWEPSAPVCEK-ECQAPPNILNGQKEDRHM 426 Query: 2609 L---VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHG 2665 + GT + Y CN GY L +E + C S+G W+ P+C V C + G Sbjct: 427 VRFDPGTSIKYSCNPGYVLVGEE--SIQCTSEGVWTP--PVPQCKVAACEAT-------G 475 Query: 2666 RWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTP 2725 R + H + V SC GY G EC GT W E C+ I+C P Sbjct: 476 RQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC--QGTIPWFMEIRLCKEITCPPPPVI 533 Query: 2726 PNGNKIGTQTS---YGSTAIFTCDLG------FMLVGSAVRECLSS----GLWSESETRC 2772 NG G+ YG+T +TC+ G F L+G + C S+ G WS C Sbjct: 534 YNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLC 593 Query: 2773 ----LAGHCGIPELIVNGQVIGEN--YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQ 2826 LA C + ++ G+ Y Y DTV ++C GF L GSS C+ D+ W + Sbjct: 594 KLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPE 653 Query: 2827 LPSCVPVSCGHPGSPIYGRTSGNGFNF---NDVVTFSCNIGYLMQGPTKAQCQANRQWSH 2883 +P C C P +GR +G F V ++C+ GYL+ G C + WS Sbjct: 654 IPVCEK-GCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSP 712 Query: 2884 PPPMCKV----VNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQP 2939 P C+ V S +PA S+ E +V C GY L G + +CQ Sbjct: 713 SAPRCEETCQHVRQSLQELPAGSRVE------------LVNTSCQDGYQLTGHAYQMCQD 760 Query: 2940 --NGQWDKPLPECIMIDCGHPGVPPNAVLSG---EKYTFGSTVHYSCTGKRSLLGQSSRT 2994 NG W K +P C +I C P V N +G E + +G+ V Y C LLG+ Sbjct: 761 AENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQ 820 Query: 2995 CQLN----GHWSGSQPHCSGDATGT-CGDPGTPGHG---SRQESNFRTKSTVRYACDTGY 3046 C+ + G WSG P C T C +P HG ++ S + V C+ G+ Sbjct: 821 CRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVK-HGYKLNKTHSAYSHNDIVYVDCNPGF 879 Query: 3047 ILHGSEERTCLANGSWTGRQPEC--KA-VQCGNPGTTANGKVFRIDGTTFSS--SVIYSC 3101 I++GS C + +W P C KA + C P T NG + FS S++YSC Sbjct: 880 IMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSC 939 Query: 3102 MEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDP----GIPANGLRYGDDYVVGQNVSY 3157 +GY+L G ++ CT GTWS P+C ++C P GI GL Y G V+ Sbjct: 940 DQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGI-QKGLEPRKMYQYGAVVTL 998 Query: 3158 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRA 3190 C+ GY +E GS C + W+ + CR+ Sbjct: 999 ECEDGYMLE--GSPQSQCQSDHQWNPPLAVCRS 1029 Score = 225 bits (573), Expect = 7e-58 Identities = 188/661 (28%), Positives = 270/661 (40%), Gaps = 75/661 (11%) Query: 2828 PSCVPVSCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQC----QANRQW 2881 P + +SCG P + GR S V+ +SC+ + + G C + + W Sbjct: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75 Query: 2882 SHPPPMCKVVN----CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLIC 2937 P P C+ N C +P +P K + +G V + C + + G+ + C Sbjct: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTP---YRHGDSVTFACKTNFSMNGNKSVWC 132 Query: 2938 QPNGQWDKP-LPECIMI---DCGHPGVPPNAVLSGE---KYTFGSTVHYSCTGKRSLLGQ 2990 Q N W LP C+ + +C + N + E G +V YSC L+G+ Sbjct: 133 QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192 Query: 2991 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESN-FRTKSTVRYACDTGYILH 3049 C +G WS P C C G +G +E R T + CD GY L Sbjct: 193 KIINCLSSGKWSAVPPTCE---EARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQ 249 Query: 3050 GSEERTCLANG---SWTGRQPECKAVQCGNPGTTANGKVF--RIDGTTFSSSVIYSC--- 3101 G C+ G +WT + P C+ + C +P NG+ + ++ S V Y+C Sbjct: 250 GPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPD 308 Query: 3102 -MEG--YILSGPSVRQCTAN----GTWSGTLPNCTI----ISCGDPGIPANGLRYG--DD 3148 EG +IL G S +CT + GTWSG P C + + C P I + G D Sbjct: 309 PEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDR 368 Query: 3149 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG-- 3206 Y V + C G+T L GS+ C GTW P C C PP I NG+ E Sbjct: 369 YTYNDTVIFACMFGFT--LKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRH 425 Query: 3207 -TNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGK 3265 FD G SI Y C+PGY L + C G W+ VPQC C G K + + Sbjct: 426 MVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQ 485 Query: 3266 SFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNN 3325 + +V+ SC + L GS + CQ W C E T C P V +G+ Sbjct: 486 --FVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEIT---CPPPPVIYNGAHTG 540 Query: 3326 TF--GFQVGSVVQFHCKKG-------HLLQGSTTRTCLPDL---TWSGIQPEC----IPH 3369 + F G+ V + C G L+ ST R D TWSG P C + Sbjct: 541 SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAV 600 Query: 3370 SCKQPETPAHANVVGMDLP-SHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEA 3428 C + G + P + T+ + C GF L G ++ R C++DNTW ++P+CE Sbjct: 601 QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIR-CKADNTWDPEIPVCEK 659 Query: 3429 G 3429 G Sbjct: 660 G 660 Score = 206 bits (525), Expect = 3e-52 Identities = 158/570 (27%), Positives = 242/570 (42%), Gaps = 68/570 (11%) Query: 2552 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNG---GILTTDY 2608 V +C G++L G C+ G W + C+ I+C P NG G D+ Sbjct: 491 VNSSCGEGYKLSGSVYQECQ----GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDF 546 Query: 2609 LVGTRVTYFCNDG----YRLSSKELTTAVCQSD----GTWSNHNKTPRC----VVVTCPS 2656 GT VTY CN G S +T C S+ GTWS P C + V C Sbjct: 547 PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSG--PAPLCKLSLLAVQCSH 604 Query: 2657 INSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQI 2716 ++ + +G + Y Y V F C G+ G + I C + TW E P C+ Sbjct: 605 VH---IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWD--PEIPVCEK 659 Query: 2717 ISCGELPTPPNGNKIGTQTSY---GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC- 2772 C P +G G T + G T +TCD G++LVG+ C+ SG WS S RC Sbjct: 660 -GCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCE 718 Query: 2773 -LAGHC--GIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHN--WSGQL 2827 H + EL +V + V C G++L G + ++CQ N W ++ Sbjct: 719 ETCQHVRQSLQELPAGSRV--------ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKI 770 Query: 2828 PSCVPVSCGHPGSPIYGRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ---- 2880 P C + C P + G+ +G F + + V++ C+ G+ + G K QC+++ + Sbjct: 771 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS 830 Query: 2881 WSHPPPMC----KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2936 WS P P C V C +P + K H +++ +V+ DCNPG+ + GS V+ Sbjct: 831 WSGPSPQCLRSPPVTRCPNPEVKHGYKLNKT--HSAYSHNDIVYVDCNPGFIMNGSRVIR 888 Query: 2937 CQPNGQWDKPLPECI---MIDCGHPGVPPNAVLSG---EKYTFGSTVHYSCTGKRSLLGQ 2990 C + W +P CI I C P PN +G +++ G ++ YSC L+G+ Sbjct: 889 CHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGE 948 Query: 2991 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHG 3050 + C G WS PHC + D G ++ + V C+ GY+L G Sbjct: 949 ALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEG 1008 Query: 3051 SEERTCLANGSWTGRQPECKA-----VQCG 3075 S + C ++ W C++ V CG Sbjct: 1009 SPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 1038 Score = 157 bits (397), Expect = 2e-37 Identities = 271/1162 (23%), Positives = 401/1162 (34%), Gaps = 283/1162 (24%) Query: 1825 FVYQAVPRTSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVP 1882 F+ P C S P GR AVG+ + + C+ + L G ++ C T Sbjct: 10 FLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKD 69 Query: 1883 NSLAQWNDSLPTC------------IVPCG----GILTKRKGTILSPGYPEPYDNNLN-C 1925 W+ P C IVP G G R G ++ + N N Sbjct: 70 KVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS 129 Query: 1926 VWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYS-GTTIPHLLNSTSNN 1984 VW ++ +L G + + +GS + G ++ + S + Sbjct: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTY---SCESG 186 Query: 1985 LYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG------IKIGDRYMVGDVVSFQC 2038 L + I+ ++G +++A+ +C E + S G +K VG +F C Sbjct: 187 YLLVGEKIINCLSSG---KWSAVP-PTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFC 242 Query: 2039 DQGYSLQGHSHITCM-PGPVRRWNYPIPICLAQ-CGGAMSDFSGVILSPGFPGNYPSSLD 2096 D+GY LQG C+ G W +P+C C +G + S+ Sbjct: 243 DEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI- 300 Query: 2097 CTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHE 2156 T+T + GV+ + ST L S +T T SGP P ST+ Sbjct: 301 VTYTCDPDPEEGVNFILIGEST------LRCTVDSQKTGT----WSGPA-PRCELSTS-- 347 Query: 2157 TSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGND--FTVGQTISFECFPGY 2214 CP P+ R V G +T T+ F C G+ Sbjct: 348 ------------------------AVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGF 383 Query: 2215 TLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNG-------TIYSPGYPDEY---P 2264 TL G+ + C W P CE C +NG + PG +Y P Sbjct: 384 TLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441 Query: 2265 NF-----------QDCFWLVRVPPGNGIYINFTVLQ--TEPIYDFITVWDGPDQNSPQIG 2311 + + W VP T Q T+P + F+ PD NS G Sbjct: 442 GYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR----PDVNS-SCG 496 Query: 2312 QFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQ----PPPPV--PNAE 2365 + G SVY + F ++R+C+ PPPPV A Sbjct: 497 E--GYKLSGSVYQECQGTIPWF----------------MEIRLCKEITCPPPPVIYNGAH 538 Query: 2366 ILTEDDEFEIGDIIRYQCLPG------FTLVGNAILTCRLG--ERLQMDGAPPVCQVLCP 2417 + ++F G + Y C PG F+L+G + + C ER G P+C++ Sbjct: 539 TGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL--- 595 Query: 2418 ANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDG 2477 + L + + V ++ GY S YN T+ + Y G Sbjct: 596 -SLLAVQCSHVHIANGYKIS---------GKEAPYFYNDTV------------TFKCYSG 633 Query: 2478 PNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPH 2537 ++ I D + W + +KG C +P H Sbjct: 634 FTLKGSSQIRCKADNT---------------WDPEIPVCEKG---------CQSPPGLHH 669 Query: 2538 GYIISQTGGQL-----NSVVRWACDRGFRLVGKSSAVCRKSSY----------------- 2575 G TGG V + CD G+ LVG S C S Sbjct: 670 G---RHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETCQHVRQ 726 Query: 2576 --------------------GY----HA-----------WDAPVPACQAISCGIPKAPTN 2600 GY HA W +P C+ I C P N Sbjct: 727 SLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVN 786 Query: 2601 G---GILTTDYLVGTRVTYFCNDG-YRLSSKELTTAVCQSD----GTWSNHNKTPRCV-- 2650 G G++ ++L G V+Y C+ G Y L K+L C+SD G+WS +P+C+ Sbjct: 787 GKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQ---CRSDSKGHGSWS--GPSPQCLRS 841 Query: 2651 --VVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWR 2708 V CP+ ++HG S Y + V C+PG+ G I C + TW Sbjct: 842 PPVTRCPNPE---VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWV-- 896 Query: 2709 NERPYC---QIISCGELPTPPNGNKIG---TQTSYGSTAIFTCDLGFMLVGSAVRECLSS 2762 P C I C P PNGN G + S G + +++CD G++LVG A+ C Sbjct: 897 PGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHE 956 Query: 2763 GLWSESETRCLAGHCGIP---ELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQ 2819 G WS+ C +C P + I G + Y Y V +C G+ L GS CQ Sbjct: 957 GTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQS 1016 Query: 2820 DHNWSGQLPSC-----VPVSCG 2836 DH W+ L C PV CG Sbjct: 1017 DHQWNPPLAVCRSRSLAPVLCG 1038 Score = 99.0 bits (245), Expect = 8e-20 Identities = 78/276 (28%), Positives = 114/276 (41%), Gaps = 24/276 (8%) Query: 3184 VMPTCRAVTCPTPPQISNGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVG----NG 3237 V P ++C +PP I NGR+ T G I Y CS + L L C+ +G Sbjct: 14 VAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDG 73 Query: 3238 TWSGEVPQC--LPKF--CGDPGIPAQGKREGKS-FIYQSEVSFSCNFPFILVGSSTRICQ 3292 TW P+C K+ C +P +P K G + + + V+F+C F + G+ + CQ Sbjct: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133 Query: 3293 ADGTWSGSS-PHCIEPTQTSCENPGVPR----HGSQNNTFGFQVGSVVQFHCKKGHLLQG 3347 A+ W + P C+ C P +P H + N G V + C+ G+LL G Sbjct: 134 ANNMWGPTRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191 Query: 3348 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGG 3407 CL WS + P C CK + V + G T + C G+ L G Sbjct: 192 EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251 Query: 3408 TEHR--VCRSDNTWTGKVPICEAGSKILVKDPRPAL 3441 R + WT K+P+CE +I P P L Sbjct: 252 PSSRCVIAGQGVAWT-KMPVCE---EIFCPSPPPIL 283 Score = 85.1 bits (209), Expect = 1e-15 Identities = 182/861 (21%), Positives = 272/861 (31%), Gaps = 226/861 (26%) Query: 1680 GSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH-APCGSRSTGSEGTVLSP-- 1736 G +VTY C++GY+L G + C+ W+ P+C A C S G V P Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGK----WSAVPPTCEEARCKSLGRFPNGKVKEPPI 231 Query: 1737 ---NYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSG 1793 N+ V+ GQ V + T + E++ S L+G Sbjct: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFC-----PSPPPILNG 285 Query: 1794 SHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR--------------------- 1832 H G SL S I P F + ++ R Sbjct: 286 RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELS 345 Query: 1833 TSSTQCSSVPEPRF--GRRIGNE---FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQ 1887 TS+ QC P P+ GR + + + +V+F C G+ L GS IRC N+ Sbjct: 346 TSAVQC---PHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC----NAQGT 398 Query: 1888 WNDSLPTCIVPCGG---ILTKRK----------GTIL----SPGYPEPYDNNLNC----V 1926 W S P C C IL +K GT + +PGY + ++ C V Sbjct: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458 Query: 1927 WKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLY 1986 W VP Q A E L P + S G S ++Y Sbjct: 459 WTPPVP-------QCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGY-----KLSGSVY 506 Query: 1987 LNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIG---DRYMVGDVVSFQCDQG-- 2041 Q I + +E +CP P +G G + + G V++ C+ G Sbjct: 507 QECQGTIP-----WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPE 561 Query: 2042 ----YSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDC 2097 +SL G S I C R + P L + S V ++ G+ S + Sbjct: 562 RGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYK---ISGKEA 618 Query: 2098 TWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHET 2157 + N + F + F GSS+ P+IP Sbjct: 619 PYFYNDTVTFKCYSGFT-------------LKGSSQIRCKADNTWDPEIPVCE------- 658 Query: 2158 SLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGND---FTVGQTISFECFPGY 2214 + C P +G G + F G T+ + C PGY Sbjct: 659 ------------------------KGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGY 694 Query: 2215 TLIGNSALTCLHGVSRNWNHPLPRCEALC-----------GGNITAMNGTIYSPGYPDEY 2263 L+GN ++ C+ S NW+ PRCE C G+ + T GY Sbjct: 695 LLVGNKSIHCM--PSGNWSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTG 752 Query: 2264 PNFQDC------FWLVRVP----------------------PGNGIYINFTVLQTEPIYD 2295 +Q C W ++P N +Y N + + + Sbjct: 753 HAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFY 812 Query: 2296 FI--------------TVWDGPDQN-----------SPQIGQFSGNTALESVYSTSNQIL 2330 + W GP +P++ S YS ++ + Sbjct: 813 LLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVY 872 Query: 2331 IKFHSDFTTSGFFVLSYHAYQLRV-------------CQPPPPVPNAEILTED-DEFEIG 2376 + + F +G V+ H V C PPP PN + F G Sbjct: 873 VDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPG 932 Query: 2377 DIIRYQCLPGFTLVGNAILTC 2397 I Y C G+ LVG A+L C Sbjct: 933 MSILYSCDQGYLLVGEALLLC 953 Score = 80.5 bits (197), Expect = 3e-14 Identities = 156/664 (23%), Positives = 237/664 (35%), Gaps = 164/664 (24%) Query: 1158 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPN 1216 F G ++ +SC+ GY L G I C G VW+ P+P+C VA C A+ +L P Sbjct: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSEG--VWTPPVPQCKVAACEATGRQ---LLTKPQ 483 Query: 1217 YP-LNYENNHECIYSIQVQAGKGINISARTFHLAQGDV---LKIYDGKDKTTH-----LL 1267 + + + N C G+G +S + QG + ++I K+ T Sbjct: 484 HQFVRPDVNSSC--------GEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYN 535 Query: 1268 GAFTGASMR----GLTLSSTSN---QLWLEF------------NSDTEGTDEG-FQLVYT 1307 GA TG+S+ G T++ T N + +EF N GT G L Sbjct: 536 GAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL 595 Query: 1308 SFELSHCEDPGIPQFGYKIS--DQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDY 1365 S C I GYKIS + +F T+ + C G+TL GSS ++C WD Sbjct: 596 SLLAVQCSHVHIAN-GYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKAD--NTWDP 652 Query: 1366 PLPSCIAEC-------GGRFKGESSGRILS---------PGYPFPYDNNLRCMWMIEVDP 1409 +P C C GR G ++ +S PGY + ++ CM Sbjct: 653 EIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCM-----PS 707 Query: 1410 GNIVSLQFLAFDTEASHDILRVWD-GPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTD 1468 GN W P + + + SL S + +V Sbjct: 708 GN--------------------WSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQDG 747 Query: 1469 FYISKSGFAIQFSSSVATA-------------CRDPGVPMNGTRNGDGREP---GDTVVF 1512 + + +G A Q C P V +NG G E G+ V + Sbjct: 748 YQL--TGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSY 805 Query: 1513 QCDPGYELQGEERITC-IQVENRYFWQ-------PSPPVCIAPCGGNLTGSSGFILSPNF 1564 +CD G+ L GE+++ C + W SPPV P N G+ L+ Sbjct: 806 ECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP---NPEVKHGYKLNKTH 862 Query: 1565 PHPYPHSR----DCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS-NSPLIGSFQ 1619 Y H+ DC+ +N VI + D ++ P IG Sbjct: 863 -SAYSHNDIVYVDCNPGFIMNGSRVIRC---------HTDNTWVPGVPTCIKKAFIGCPP 912 Query: 1620 DSKLPERIESSSNTMHLAFRSDGSVSYT---GFHLEYKAKL----------------RES 1660 K P + N F S+ Y+ G+ L +A L + Sbjct: 913 PPKTPNGNHTGGNIAR--FSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 970 Query: 1661 CFDPGNIMNGTRLGMD----YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 C P + M+G + G++ Y+ G+ VT C+ GY+L+G C WN L Sbjct: 971 CSSPAD-MDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC----QSDHQWNPPLA 1025 Query: 1717 SCHA 1720 C + Sbjct: 1026 VCRS 1029 Score = 72.4 bits (176), Expect = 8e-12 Identities = 138/646 (21%), Positives = 228/646 (35%), Gaps = 124/646 (19%) Query: 1678 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLSP 1736 ++G T ++CD GY LQG + C++ G W + +P C C S G + Sbjct: 233 RVGVTANFFCDEGYRLQGPPSSRCVIAGQG-VAWTK-MPVCEEIFCPSPPPILNGRHIG- 289 Query: 1737 NYPKNYSVGHNCVYSIAVPKE----FVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLS 1792 N N S G Y+ E F++ G+ T + GP + L +S Sbjct: 290 NSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349 Query: 1793 GSHSGESLP--LSSGNQI------TIRFTSVGPITAKGFHFV-------YQAVPRTSSTQ 1837 + L + SG + T+ F + T KG + ++ + Sbjct: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKE 409 Query: 1838 CSSVPEPRFGRRIGNE---FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894 C + P G++ F G+S+ + CNPGY+L G +I+C S W +P Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC----TSEGVWTPPVPQ 465 Query: 1895 C-IVPCGG----ILTKRKGTILSPG---------------YPE-----PYDNNLNCVWKI 1929 C + C +LTK + + P Y E P+ + +I Sbjct: 466 CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI 525 Query: 1930 TVPEGAGIQVQVVSFATEHNWDSLDFYDGGD------NNAPRLGSYSGTTIPHLLNSTSN 1983 T P V + H SL+ + G N P G + TSN Sbjct: 526 TCPP------PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579 Query: 1984 NLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDR---YMVGDVVSFQCDQ 2040 + + S A L A+ C ++G KI + Y D V+F+C Sbjct: 580 D---QERGTWSGPAPLCKLSLLAV---QCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYS 632 Query: 2041 GYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGF-PGNYPSSLDCTW 2099 G++L+G S I C W+ IP+C C PG G + + Sbjct: 633 GFTLKGSSQIRCKAD--NTWDPEIPVCEKGCQS----------PPGLHHGRHTGGNTVFF 680 Query: 2100 TINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSL 2159 + + + ++ ++IH + SG+ S + + SL + + Sbjct: 681 VSGMTVDYTCDPGYLLVGNKSIHC---MPSGNWSPSAPRCEETCQHVRQSLQELPAGSRV 737 Query: 2160 YFHSDYSQNKQGFHIVYQAYQLQS------------------CPDPRPFRNG---FVIGN 2198 + Q+ G+ + AYQ+ C P NG ++ Sbjct: 738 ELVNTSCQD--GYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAE 795 Query: 2199 DFTVGQTISFECFPGYTLIGNSALTCL-----HGVSRNWNHPLPRC 2239 +F G +S+EC G+ L+G L C HG +W+ P P+C Sbjct: 796 NFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHG---SWSGPSPQC 838 Score = 62.4 bits (150), Expect = 8e-09 Identities = 145/624 (23%), Positives = 214/624 (34%), Gaps = 142/624 (22%) Query: 989 GSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALCGGDVRGPSGTILSP------ 1041 G +V++SC+SGY L E+ + C + WS PTC +A C R P+G + P Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235 Query: 1042 ---------GYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP 1092 GY P S C V G+GV + + + E P Sbjct: 236 VTANFFCDEGYRLQGPPSSRC-----VIAGQGVAWT-----------KMPVCEEIFCPSP 279 Query: 1093 LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGS 1152 PP +N GN A ++SY G +T Y +P + G+ Sbjct: 280 ---------PPILNGRHIGNSLA--------NVSY-GSIVT---YTCDPDPEEGV----- 313 Query: 1153 RIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGIL 1212 NF + T C+ + GT WS P PRC A + IL Sbjct: 314 ----NFILIGESTLRCTVDSQKTGT------------WSGPAPRCELSTSAVQCPHPQIL 357 Query: 1213 -------LSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--------IY 1257 Y N C++ ++ K I +A+ V + I Sbjct: 358 RGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNIL 417 Query: 1258 DGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDP 1317 +G+ + H++ G S++ S + L + T EG V+T + C+ Sbjct: 418 NGQKEDRHMVRFDPGTSIK----YSCNPGYVLVGEESIQCTSEG---VWTP-PVPQCKVA 469 Query: 1318 GIPQFGYKI--SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC-IAEC 1374 G ++ Q F + C GY L GS +C W + C C Sbjct: 470 ACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ--GTIPWFMEIRLCKEITC 527 Query: 1375 GGR---FKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1427 + G +G L FPY + +PG ++F S+D Sbjct: 528 PPPPVIYNGAHTGSSLE---DFPYGTTV----TYTCNPGPERGVEFSLIGESTIRCTSND 580 Query: 1428 ILR-VWDGPP---ENDMLLKEISGSLIPEGIH-STLNIVTIQFDTDFYISKSGFAIQFSS 1482 R W GP + +L + S I G S DT + SGF ++ SS Sbjct: 581 QERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSS 640 Query: 1483 SV---ATACRDPGVPM------------NGTRNGDGR---EPGDTVVFQCDPGYELQGEE 1524 + A DP +P+ +G G G TV + CDPGY L G + Sbjct: 641 QIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNK 700 Query: 1525 RITCIQVENRYFWQPSPPVCIAPC 1548 I C+ N W PS P C C Sbjct: 701 SIHCMPSGN---WSPSAPRCEETC 721 Score = 58.9 bits (141), Expect = 9e-08 Identities = 134/619 (21%), Positives = 214/619 (34%), Gaps = 128/619 (20%) Query: 1160 IGDTLTFSCSSGYRLEGTSEIICLGGGR--RVWSAPLPRCVAECGASATNNEGILLSPNY 1217 +G + +SCS +RL G ++C+ + W P P+C Sbjct: 43 VGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC-------------------- 82 Query: 1218 PLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRG 1277 Y N + V G I S H GD + T SM G Sbjct: 83 --EYFNKYSSCPEPIVPGGYKIRGSTPYRH---GDSV-----------TFACKTNFSMNG 126 Query: 1278 LTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GYKISDQ-GHFA- 1333 + +W + N+ G + T + E P +P G+ S+ G A Sbjct: 127 ------NKSVWCQANNMW-----GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP 175 Query: 1334 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC-IAECG--GRFK----------- 1379 G ++ Y C GY L G ++ C++ + W P+C A C GRF Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCEEARCKSLGRFPNGKVKEPPILR 233 Query: 1380 -GESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP-- 1436 G ++ GY + RC +++ Q +A+ + + PP Sbjct: 234 VGVTANFFCDEGYRLQGPPSSRC----------VIAGQGVAWTKMPVCEEIFCPSPPPIL 283 Query: 1437 ----ENDMLLKEISGSLI--------PEGIHSTL---NIVTIQFDTDFYISKSGFAIQFS 1481 + L GS++ EG++ L + + D+ + SG A + Sbjct: 284 NGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCE 343 Query: 1482 -SSVATACRDPGVPMNGTRNG--DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQ 1538 S+ A C P + +G D DTV+F C G+ L+G ++I C + W+ Sbjct: 344 LSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC---NAQGTWE 400 Query: 1539 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVI----SLAFISFS 1594 PS PVC C +G H + N YV+ S+ S Sbjct: 401 PSAPVCEKECQAPPNILNG---QKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEG 457 Query: 1595 I-EPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSV-----SYTG 1648 + P + + L+ Q + + SS ++ GSV Sbjct: 458 VWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE---GYKLSGSVYQECQGTIP 514 Query: 1649 FHLEYKAKLRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYSTL 1699 + +E + +C P I NG G D+ G+TVTY C+ G + L G ST+ Sbjct: 515 WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574 Query: 1700 TCIMGDDGRPGWNRALPSC 1718 C D R W+ P C Sbjct: 575 RCTSNDQERGTWSGPAPLC 593 Score = 57.8 bits (138), Expect = 2e-07 Identities = 110/479 (22%), Positives = 162/479 (33%), Gaps = 111/479 (23%) Query: 1141 PCEDPGIPQY--GSRIGFNFGI---GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLP 1195 P E P +P G N G G ++T+SC SGY L G I CL G+ WSA P Sbjct: 151 PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPP 208 Query: 1196 RC-VAECGASATNNEGILLSP---------------NYPLNYENNHECIYSIQVQAG--- 1236 C A C + G + P Y L + C+ + Q A Sbjct: 209 TCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKM 268 Query: 1237 ---------------KGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLS 1281 G +I +++ G ++ D + G S T+ Sbjct: 269 PVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVD 328 Query: 1282 STSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQ--GHFAGSTIIY 1339 S W G +L S C P I + G +S Q + T+I+ Sbjct: 329 SQKTGTW-------SGPAPRCEL---STSAVQCPHPQILR-GRMVSGQKDRYTYNDTVIF 377 Query: 1340 GCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGG---------------RF-KGESS 1383 C G+TL GS ++C + W+ P C EC RF G S Sbjct: 378 ACMFGFTLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSI 435 Query: 1384 GRILSPGYPFPYDNNLRC----MWMIEVDPGNIVSLQFLAFD--TEASHDILRVWDGPPE 1437 +PGY + +++C +W V + + + T+ H +R P Sbjct: 436 KYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR----PDV 491 Query: 1438 NDMLLK--EISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495 N + ++SGS+ E TI + + + K C P V Sbjct: 492 NSSCGEGYKLSGSVYQECQG------TIPWFMEIRLCKE-----------ITCPPPPVIY 534 Query: 1496 NGTRNGDGREP---GDTVVFQCDPG------YELQGEERITCI-QVENRYFWQPSPPVC 1544 NG G E G TV + C+PG + L GE I C + R W P+C Sbjct: 535 NGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLC 593 Score = 54.3 bits (129), Expect = 2e-06 Identities = 64/286 (22%), Positives = 113/286 (39%), Gaps = 48/286 (16%) Query: 1646 YTGFHLEYKAKLR---------------ESCFDPGNIMNGTRLGMD---YKLGSTVTYYC 1687 Y+GF L+ +++R + C P + +G G + + G TV Y C Sbjct: 631 YSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTC 690 Query: 1688 DAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPC-------GSRSTGSEGTVLSPNYPK 1740 D GY+L G ++ C+ + W+ + P C C GS +++ + Sbjct: 691 DPGYLLVGNKSIHCMPSGN----WSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQD 746 Query: 1741 NYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLH------DVVEVYDGPTQQSSLLSSLSG 1793 Y + GH Y + E ++ + + +H V + G ++ L + Sbjct: 747 GYQLTGH--AYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVS 804 Query: 1794 SHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG-- 1851 + L ++ R S G + G Q + T+C + PE + G ++ Sbjct: 805 YECDQGFYLLGEKKLQCRSDSKGHGSWSGPS--PQCLRSPPVTRCPN-PEVKHGYKLNKT 861 Query: 1852 -NEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1896 + ++ V DCNPG+I++GS IRC T W +PTCI Sbjct: 862 HSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT----WVPGVPTCI 903 Score = 51.2 bits (121), Expect = 2e-05 Identities = 64/252 (25%), Positives = 92/252 (36%), Gaps = 59/252 (23%) Query: 970 CLDPGIPVHGRRYG---HDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHW-WSHPLPT 1022 C P + V+G+ G +F G+ VS+ CD G+ L E+ L C K H WS P P Sbjct: 778 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 837 Query: 1023 CDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLL 1082 C +R P T PN +V HG + T H+D + Sbjct: 838 C-------LRSPPVTRC--------PNP-------EVKHGYKLN---KTHSAYSHNDIVY 872 Query: 1083 ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1142 + N F +R+ T G+ + FI C Sbjct: 873 VDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKA--FIG--------------------C 910 Query: 1143 EDPGIPQYGSRIGFN---FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1199 P G+ G N F G ++ +SC GY L G + ++C G WS P P C Sbjct: 911 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEG--TWSQPAPHCKE 968 Query: 1200 ECGASATNNEGI 1211 +S + +GI Sbjct: 969 VNCSSPADMDGI 980 Score = 49.3 bits (116), Expect = 7e-05 Identities = 91/414 (21%), Positives = 146/414 (35%), Gaps = 88/414 (21%) Query: 635 REGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLS 694 +E F N D + F+C GF L G I C+ +N W IP+ C +P G Sbjct: 616 KEAPYFYN-DTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPV----CEKGCQSPPGL--- 667 Query: 695 PDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVKDGD-SPESPILGTFT 752 + G N T+ G + + + + L + G+ SP +P T Sbjct: 668 -HHGRHTGGN-----TVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEE-T 720 Query: 753 GAEVPSHLT-----SNSHILRLEFQADHSMSGRGFNITYNTFGHN-----------ECPD 796 V L S ++ Q + ++G + + + C Sbjct: 721 CQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHP 780 Query: 797 PGIPINARRFG---DNFQLGSSISVICEEGFIKTQGTETITCIL-MDGKVMWSGLIPKCG 852 P + +N + G +NF G+ +S C++GF G + + C G WSG P+C Sbjct: 781 PPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLL-GEKKLQCRSDSKGHGSWSGPSPQCL 839 Query: 853 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVH 912 S P +P E + G+ + T + + D++ V Sbjct: 840 R------SPPVTRCPNP----------------EVKHGYKLNKTHSAYS---HNDIVYVD 874 Query: 913 DGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLD 972 P + NG++V + TDN+ G + + C Sbjct: 875 CNPGFIM------NGSRV------------IRCHTDNTWVP-GVPTCIKKAFIG---CPP 912 Query: 973 PGIPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023 P +G G + FS G ++ +SCD GY L E LLC WS P P C Sbjct: 913 PPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHC 966 Score = 45.8 bits (107), Expect = 8e-04 Identities = 90/440 (20%), Positives = 155/440 (35%), Gaps = 81/440 (18%) Query: 638 DGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDY 697 D ++ D + F C FGF L G K I C W + P+C C AP P+ Sbjct: 367 DRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKEC----QAP------PNI 416 Query: 698 PEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDG----DSPESPILG-TF 751 G + + + DPG+ I S N + L + +G P+ + Sbjct: 417 LNGQKEDRH---MVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEA 473 Query: 752 TGAEVPSHLTSNSH-ILRLEFQADHSMSGRGFNITYNTFGHNE----------------C 794 TG ++ LT H +R + +S G G+ ++ + + + C Sbjct: 474 TGRQL---LTKPQHQFVRPDV---NSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITC 527 Query: 795 PDPGIPINARRFG---DNFQLGSSISVICEEG-----FIKTQGTETITCILMD-GKVMWS 845 P P + N G ++F G++++ C G G TI C D + WS Sbjct: 528 PPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWS 587 Query: 846 GLIPKC-----GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE-R 899 G P C C A I P +Y D++ + G ++K + + R Sbjct: 588 GPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTV----TFKCYSGFTLKGSSQIR 643 Query: 900 FQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLL--FTTDNSRSNNGFK 957 + + +D P + G + + + N ++ + T D + Sbjct: 644 CKADNTWD-------PEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLL 696 Query: 958 IHYESVTVNTYSCLDPGIP------VHGRRYGHDFSIGSTVSF---SCDSGYRLSHEEPL 1008 + +S+ P P H R+ + GS V SC GY+L+ Sbjct: 697 VGNKSIHCMPSGNWSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQ 756 Query: 1009 LCE--KNHWWSHPLPTCDAL 1026 +C+ +N W +P C + Sbjct: 757 MCQDAENGIWFKKIPLCKVI 776 Score = 45.1 bits (105), Expect = 0.001 Identities = 56/247 (22%), Positives = 85/247 (34%), Gaps = 78/247 (31%) Query: 972 DPGIPV------------HGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWW 1016 DP IPV HGR G + F G TV ++CD GY L + + C + W Sbjct: 651 DPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNW 710 Query: 1017 SHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHL-E 1075 S P C+ C VR + + E V+ + G Q H + + + Sbjct: 711 SPSAPRCEETC-QHVRQSLQELPAGSRVEL----------VNTSCQDGYQLTGHAYQMCQ 759 Query: 1076 DHHDYLLITENGSFTQ--PLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNIT 1133 D ENG + + PL ++ PP I G + A+ Sbjct: 760 D-------AENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAE----------------- 795 Query: 1134 FSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG--GRRVWS 1191 NF G+ +++ C G+ L G ++ C G WS Sbjct: 796 -----------------------NFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 832 Query: 1192 APLPRCV 1198 P P+C+ Sbjct: 833 GPSPQCL 839 Score = 45.1 bits (105), Expect = 0.001 Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 7/75 (9%) Query: 439 IKTASNLCPDPGEPENGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAA 495 IK A CP P + NG G + FS G ++ +SCD+ Y+L G + C Sbjct: 903 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTH----EGT 958 Query: 496 WSDHRPVCKVKTCGS 510 WS P CK C S Sbjct: 959 WSQPAPHCKEVNCSS 973 Score = 44.7 bits (104), Expect = 0.002 Identities = 187/872 (21%), Positives = 282/872 (32%), Gaps = 178/872 (20%) Query: 793 ECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 849 ECP + N +N G S++ CE G++ G + I C L GK WS + P Sbjct: 153 ECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV-GEKIINC-LSSGK--WSAVPP 208 Query: 850 KCG-APCGGHFSAPSGVILSP---------------GWPGYYKDSLNCEWVIEAEPGHSI 893 C A C P+G + P G+ S C + + Sbjct: 209 TCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKM 268 Query: 894 KITFERFQTELNYDVLEVHDGPNLLSPLLGS---YNGTQVPQFLFSSSNFIY-----LLF 945 + E F + H G +L + GS Y P+ NFI L Sbjct: 269 PVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE---EGVNFILIGESTLRC 325 Query: 946 TTDNSRSN--NGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGY 1000 T D+ ++ +G E ++ + C P I + GR ++ TV F+C G+ Sbjct: 326 TVDSQKTGTWSGPAPRCE-LSTSAVQCPHPQI-LRGRMVSGQKDRYTYNDTVIFACMFGF 383 Query: 1001 RLSHEEPLLCEKNHWWSHPLPTCDALCGGD-------------VRGPSGTIL----SPGY 1043 L + + C W P C+ C VR GT + +PGY Sbjct: 384 TLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGY 443 Query: 1044 PEFYPNSLNCT----WTVDVTHGK--GVQFNFHTFHLEDHHDYLLITENGSFTQPLARLT 1097 S+ CT WT V K + + H ++ N S + +L+ Sbjct: 444 VLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGY-KLS 502 Query: 1098 GSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGF- 1156 GS +Y + + + + + E IT C P + G+ G Sbjct: 503 GS---------VYQECQGTIPWFMEIRLCKE---IT--------CPPPPVIYNGAHTGSS 542 Query: 1157 --NFGIGDTLTFSCSSG------YRLEGTSEIICLGGG--RRVWSAPLPRC-----VAEC 1201 +F G T+T++C+ G + L G S I C R WS P P C +C Sbjct: 543 LEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC 602 Query: 1202 GASATNNEGILLSPNYPLNYEN--NHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDG 1259 N + P Y + +C ++ I A + V + Sbjct: 603 SHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQ 662 Query: 1260 KDKTTHLLGAFTGAS----MRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1315 H G TG + + G+T+ T D G+ LV + HC Sbjct: 663 SPPGLH-HGRHTGGNTVFFVSGMTVDYT--------------CDPGYLLV--GNKSIHCM 705 Query: 1316 -----DPGIPQF-----GYKISDQGHFAGSTIIY---GCNPGYTLHGSSLLKCMTGERRA 1362 P P+ + S Q AGS + C GY L G + C E Sbjct: 706 PSGNWSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGI 765 Query: 1363 WDYPLPSC-IAECGGR---FKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFL 1418 W +P C + C G+ +G + F Y N + E D G L Sbjct: 766 WFKKIPLCKVIHCHPPPVIVNGKHTGMMAE---NFLYGNEV----SYECDQG-FYLLGEK 817 Query: 1419 AFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGIHS-TLNIVTIQFDTD--FYISKSG 1475 + W GP + ++ PE H LN + + Y+ + Sbjct: 818 KLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNP 877 Query: 1476 FAIQFSSSVATACRD----PGVPM----------------NGTRNGDG---REPGDTVVF 1512 I S V D PGVP NG G PG ++++ Sbjct: 878 GFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILY 937 Query: 1513 QCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544 CD GY L GE + C + W P C Sbjct: 938 SCDQGYLLVGEALLLC---THEGTWSQPAPHC 966 Score = 43.1 bits (100), Expect = 0.005 Identities = 23/54 (42%), Positives = 28/54 (51%), Gaps = 5/54 (9%) Query: 153 RFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMR 206 RFD G I+YSC GY+L G + C + V W PVP C+ AC T R Sbjct: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGV----WTPPVPQCKVA-ACEATGR 476 Score = 42.4 bits (98), Expect = 0.009 Identities = 24/61 (39%), Positives = 28/61 (45%), Gaps = 2/61 (3%) Query: 137 SCGNPGVPPKGVL--YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 SCG+P G + Y T VG IRYSC + L G L CI +WD P P Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81 Query: 195 C 195 C Sbjct: 82 C 82 Score = 42.4 bits (98), Expect = 0.009 Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 2/58 (3%) Query: 623 SCGDPGTPL-YGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWS-ANIPICI 678 SC +P P Y IR + + D + F C+ F + G KS+ CQ NN W +P C+ Sbjct: 90 SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCV 147 Score = 42.4 bits (98), Expect = 0.009 Identities = 54/262 (20%), Positives = 91/262 (34%), Gaps = 42/262 (16%) Query: 446 CPDPGEPENGKRIG---SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502 C P NGK G +F G+ V + CD+ + L G K + C+ ++ +WS P Sbjct: 778 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 837 Query: 503 CKVKTCGSNLQGPSGT-FTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561 C L+ P T +P Y N +A + N ++ ++ + G Sbjct: 838 C--------LRSPPVTRCPNPEVKHGYKLNK----THSAYSHNDIVYVDCNPGFIMNGSR 885 Query: 562 TLTIGDGGE--VGDPRTVLQVLTGSFVPDL----------IVSMSSQMWLHLQTDESVGS 609 + G P + + G P I S M + D+ Sbjct: 886 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL 945 Query: 610 VGFKV--------------NYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFE 655 VG + + KE+ S D G+ + V+ EC+ G+ Sbjct: 946 VGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM 1005 Query: 656 LIGEKSIVCQENNQWSANIPIC 677 L G CQ ++QW+ + +C Sbjct: 1006 LEGSPQSQCQSDHQWNPPLAVC 1027 Score = 41.2 bits (95), Expect = 0.019 Identities = 60/256 (23%), Positives = 100/256 (39%), Gaps = 33/256 (12%) Query: 446 CPDPGEPENGKRIGS---DFSLGSTVQFSCDE------DYVLQGAKSITCQRIAEVFAAW 496 CP P NG GS DF G+TV ++C+ ++ L G +I C + W Sbjct: 527 CPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586 Query: 497 SDHRPVCKVKTCG---SNLQGPSG-TFTSPNFPFQYDSNA--QCVWVITAVNTNKVIQIN 550 S P+CK+ S++ +G + P+ Y+ +C T ++++ Sbjct: 587 SGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKA 646 Query: 551 FEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGS----FVPDLIVSMSSQMWLHLQTDES 606 +D EI + + G P TG FV + V + L ++S Sbjct: 647 DNTWDPEI-----PVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKS 701 Query: 607 V---GSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIV 663 + S + + E E+C L + G S +++ CQ G++L G + Sbjct: 702 IHCMPSGNWSPSAPRCE-ETCQHVRQSLQELPAG---SRVELVNTSCQDGYQLTGHAYQM 757 Query: 664 CQ--ENNQWSANIPIC 677 CQ EN W IP+C Sbjct: 758 CQDAENGIWFKKIPLC 773 Score = 40.4 bits (93), Expect = 0.033 Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 9/71 (12%) Query: 446 CPDPGEPENGKRIGSDF---SLGSTVQFSCDED------YVLQGAKSITCQRIAEVFAAW 496 CP P NG+ IG+ S GS V ++CD D ++L G ++ C ++ W Sbjct: 276 CPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTW 335 Query: 497 SDHRPVCKVKT 507 S P C++ T Sbjct: 336 SGPAPRCELST 346 Score = 38.9 bits (89), Expect = 0.095 Identities = 60/261 (22%), Positives = 98/261 (37%), Gaps = 36/261 (13%) Query: 1660 SCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717 SC P I+NG + +G+ + Y C + L G +L CI D W++ P Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81 Query: 1718 CH------------APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQF- 1764 C P G + G S Y SV C + ++ V+ Q Sbjct: 82 CEYFNKYSSCPEPIVPGGYKIRG------STPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135 Query: 1765 -VFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF 1823 ++ T L V V+ P + +L +G H+ E++ S +++ ++ G Sbjct: 136 NMWGPTRLPTCVSVF--PLECPALPMIHNGHHTSENVG-SIAPGLSVTYSCESGYLLVGE 192 Query: 1824 HFV-------YQAVPRT-SSTQCSSVPE-PRFGRRIGNEFAVGSSVLFDCNPGYILHGSI 1874 + + AVP T +C S+ P + VG + F C+ GY L G Sbjct: 193 KIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPP 252 Query: 1875 AIRCETVPNSLAQWNDSLPTC 1895 + RC +A W +P C Sbjct: 253 SSRCVIAGQGVA-WT-KMPVC 271 Score = 37.7 bits (86), Expect = 0.21 Identities = 74/300 (24%), Positives = 108/300 (36%), Gaps = 61/300 (20%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C G NGK + +G T F CDE Y LQG S C IA AW+ PVC+ Sbjct: 215 CKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCV-IAGQGVAWT-KMPVCE 272 Query: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDTL 563 C S +G + +N ++T + + +NF + IG TL Sbjct: 273 EIFCPSPPPILNGRHIGNSL-----ANVSYGSIVTYTCDPDPEEGVNF----ILIGESTL 323 Query: 564 TIG-DGGEVGD-----PRTVL----------QVLTGSFVPDLIVSMSSQMWLHLQTDESV 607 D + G PR L Q+L G V S Q + D + Sbjct: 324 RCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV-------SGQKDRYTYNDTVI 376 Query: 608 GSVGFKVNYKEIEKESCGDPGT--PLYGIREGD----------GFSNRDVLRFE------ 649 + F K ++ C GT P + E + +R ++RF+ Sbjct: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIK 436 Query: 650 --CQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSN----FTAPMGTVLSPDYPEGYG 702 C G+ L+GE+SI C W+ +P C + C + T P + PD G Sbjct: 437 YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCG 496 Score = 35.8 bits (81), Expect = 0.80 Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 6/62 (9%) Query: 969 SCLDPGIPVHGR--RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC----EKNHWWSHPLPT 1022 SC P ++GR Y ++G+ + +SC +RL E+ LLC + + W P P Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81 Query: 1023 CD 1024 C+ Sbjct: 82 CE 83 Score = 35.8 bits (81), Expect = 0.80 Identities = 56/279 (20%), Positives = 105/279 (37%), Gaps = 63/279 (22%) Query: 1134 FSEYNLEPCEDPGIPQ-YGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWS- 1191 F++Y+ C +P +P Y R + GD++TF+C + + + G + C +W Sbjct: 85 FNKYS--SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC--QANNMWGP 140 Query: 1192 APLPRCVA----ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFH 1247 LP CV+ EC P P+ + +H + G + S + + Sbjct: 141 TRLPTCVSVFPLEC-------------PALPMIHNGHHTSENVGSIAPGLSVTYSCESGY 187 Query: 1248 LAQGD--VLKIYDGK---------DKTTHLLGAFTGASMR-------GLTLSSTSNQLW- 1288 L G+ + + GK + LG F ++ G+T + ++ + Sbjct: 188 LLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYR 247 Query: 1289 LEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP---------QFGYKISDQGHFAGSTIIY 1339 L+ + G + +T + CE+ P G +++ + GS + Y Sbjct: 248 LQGPPSSRCVIAGQGVAWTKMPV--CEEIFCPSPPPILNGRHIGNSLANVSY--GSIVTY 303 Query: 1340 GCNP------GYTLHGSSLLKCMTGERR--AWDYPLPSC 1370 C+P + L G S L+C ++ W P P C Sbjct: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRC 342 Score = 35.8 bits (81), Expect = 0.80 Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 7/62 (11%) Query: 138 CGNPGVPPKGVLYG---TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 C P P G G RF G I YSC GY+L G L C + +W P P Sbjct: 910 CPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC----THEGTWSQPAPH 965 Query: 195 CR 196 C+ Sbjct: 966 CK 967 Score = 35.8 bits (81), Expect = 0.80 Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 6/49 (12%) Query: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC------DALCG 1028 + G+ V+ C+ GY L C+ +H W+ PL C LCG Sbjct: 990 YQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 1038 Score = 35.0 bits (79), Expect = 1.4 Identities = 25/81 (30%), Positives = 36/81 (44%), Gaps = 9/81 (11%) Query: 446 CPDPGEPENG----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501 CP NG + +GS + G +V +SC+ Y+L G K I C + WS P Sbjct: 154 CPALPMIHNGHHTSENVGS-IAPGLSVTYSCESGYLLVGEKIINCLSSGK----WSAVPP 208 Query: 502 VCKVKTCGSNLQGPSGTFTSP 522 C+ C S + P+G P Sbjct: 209 TCEEARCKSLGRFPNGKVKEP 229 Score = 35.0 bits (79), Expect = 1.4 Identities = 19/49 (38%), Positives = 25/49 (51%), Gaps = 1/49 (2%) Query: 648 FECQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSNFTAPMGTVLSP 695 + C+ G+ L+GEK I C + +WSA P C C S P G V P Sbjct: 181 YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEP 229 Score = 34.7 bits (78), Expect = 1.8 Identities = 15/42 (35%), Positives = 22/42 (52%) Query: 154 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 F G+++ Y C G+ L G +L C ++S SW P P C Sbjct: 797 FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQC 838 Score = 33.5 bits (75), Expect = 4.0 Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 13/88 (14%) Query: 624 CGDPGTPLYGIREG---DGFSNRDVLRFECQFGFELIGEKSIVCQENNQ----WSANIPI 676 C P + G G + F + + +EC GF L+GEK + C+ +++ WS P Sbjct: 778 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 837 Query: 677 CIFPCLSNFTAPMGTVLSPDYPEGYGNN 704 C+ + P+ +P+ GY N Sbjct: 838 CL------RSPPVTRCPNPEVKHGYKLN 859 Score = 33.1 bits (74), Expect = 5.2 Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 4/67 (5%) Query: 131 EELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 +E+ SS + KG+ + G + C GY+L+G PQ C ++ W+ Sbjct: 967 KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH----QWNP 1022 Query: 191 PVPICRA 197 P+ +CR+ Sbjct: 1023 PLAVCRS 1029 Score = 32.3 bits (72), Expect = 8.9 Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 1/49 (2%) Query: 136 SSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSV 183 SSC P VP + G T + GD + ++C T + ++G+ + C AN++ Sbjct: 89 SSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137 Score = 32.3 bits (72), Expect = 8.9 Identities = 16/43 (37%), Positives = 24/43 (55%), Gaps = 1/43 (2%) Query: 446 CPDPGEPENGKRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQ 487 CP+P P K GS + G +V F+C ++ + G KS+ CQ Sbjct: 91 CPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133 >gi|42544177 complement component (3d/Epstein Barr virus) receptor 2 isoform 2 [Homo sapiens] Length = 1033 Score = 345 bits (885), Expect = 5e-94 Identities = 284/979 (29%), Positives = 415/979 (42%), Gaps = 106/979 (10%) Query: 2529 CSTPESPPHGYI-ISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587 C +P +G I T + +V+R++C FRL+G+ S +C WD P P C Sbjct: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82 Query: 2588 QAI----SCGIPKAPTNGGIL-TTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSN 2642 + SC P P I +T Y G VT+ C + ++ + + CQ++ W Sbjct: 83 EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNK--SVWCQANNMW-G 139 Query: 2643 HNKTPRCVVV---TCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIEC 2699 + P CV V CP++ ++ +G N V +SC+ GY +G I C Sbjct: 140 PTRLPTCVSVFPLECPALP--MIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINC 197 Query: 2700 LPNGTWSWRNERPYCQIISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRE 2758 L +G WS P C+ C L PNG K G TA F CD G+ L G Sbjct: 198 LSSGKWS--AVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255 Query: 2759 CLSSG---LWSESETRCLAGHCGIPELIVNGQVIGE---NYGYRDTVVYQCNP------G 2806 C+ +G W++ C C P I+NG+ IG N Y V Y C+P Sbjct: 256 CVIAGQGVAWTKMPV-CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314 Query: 2807 FRLIGSSVRIC----QQDHNWSGQLPSC----VPVSCGHP----GSPIYGRTSGNGFNFN 2854 F LIG S C Q+ WSG P C V C HP G + G+ + + +N Sbjct: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQK--DRYTYN 372 Query: 2855 DVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFT 2914 D V F+C G+ ++G + +C A W P+C+ C P N ++E + F Sbjct: 373 DTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDR-HMVRFD 430 Query: 2915 YGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTF- 2973 GT + Y CNPGY L G + C G W P+P+C + C G +L+ ++ F Sbjct: 431 PGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATG---RQLLTKPQHQFV 487 Query: 2974 GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQES--- 3030 V+ SC L G + CQ W C TC P +G+ S Sbjct: 488 RPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCK---EITCPPPPVIYNGAHTGSSLE 544 Query: 3031 NFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECK----AVQCGN 3076 +F +TV Y C+ G + L G C +N G+W+G P CK AVQC + Sbjct: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604 Query: 3077 PGTTANGKVFRIDGTT----FSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIIS 3132 ANG ++I G ++ +V + C G+ L G S +C A+ TW +P C + Sbjct: 605 V-HIANG--YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKET 661 Query: 3133 CGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTC--TINGTWSGVMPTCRA 3190 C L G + V+ CQ GY +L G + C NG W +P C+ Sbjct: 662 CQHVRQSLQELPAGSRV---ELVNTSCQDGY--QLTGHAYQMCQDAENGIWFKKIPLCKV 716 Query: 3191 VTCPTPPQISNGRLEG---TNFDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEV 3243 + C PP I NG+ G NF +G +SY C G+ L L C G+G+WSG Sbjct: 717 IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 776 Query: 3244 PQCLPK----FCGDPGIPAQGK--REGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTW 3297 PQCL C +P + K + ++ + V CN FI+ GS C D TW Sbjct: 777 PQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTW 836 Query: 3298 SGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKGHLLQGSTTRTC 3353 P CI+ C P P+ + N+T G F G + + C +G+LL G C Sbjct: 837 VPGVPTCIKKAFIGCPPP--PKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC 894 Query: 3354 LPDLTWSGIQPECIPHSCKQPE--TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR 3411 + TWS P C +C P + + +G + C+ G+ L G + + Sbjct: 895 THEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQ 954 Query: 3412 VCRSDNTWTGKVPICEAGS 3430 C+SD+ W + +C + S Sbjct: 955 -CQSDHQWNPPLAVCRSRS 972 Score = 312 bits (800), Expect = 3e-84 Identities = 258/925 (27%), Positives = 389/925 (42%), Gaps = 114/925 (12%) Query: 2585 PACQAISCGIPKAPTNGGI--LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQS--DGTW 2640 P ISCG P NG I +T VGT + Y C+ +RL ++ + + DGTW Sbjct: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75 Query: 2641 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECL 2700 P+C S + G ++I + Y + V F+C + G S+ C Sbjct: 76 DK--PAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133 Query: 2701 PNGTWSWRNERPYCQII---SCGELPTPPNGNKIGTQTSYGSTA-----IFTCDLGFMLV 2752 N W P C + C LP NG+ T + GS A ++C+ G++LV Sbjct: 134 ANNMWG-PTRLPTCVSVFPLECPALPMIHNGHH--TSENVGSIAPGLSVTYSCESGYLLV 190 Query: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV-------IGENYGYRDTVVYQCNP 2805 G + CLSSG WS C C NG+V +G T + C+ Sbjct: 191 GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV------TANFFCDE 244 Query: 2806 GFRLIG---SSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGF---NFNDVVTF 2859 G+RL G S I Q W+ ++P C + C P + GR GN ++ +VT+ Sbjct: 245 GYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTY 303 Query: 2860 SCN------IGYLMQGPTKAQCQANRQ----WSHPPPMCKV----VNCSDPGIPANSKRE 2905 +C+ + +++ G + +C + Q WS P P C++ V C P I R Sbjct: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRG--RM 361 Query: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAV 2965 + +TY V + C G+ L GS + C G W+ P C +C PPN + Sbjct: 362 VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-EC---QAPPN-I 416 Query: 2966 LSGEK-------YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGD 3018 L+G+K + G+++ YSC L+G+ S C G W+ P C A G Sbjct: 417 LNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGR 476 Query: 3019 PGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPG 3078 ++ + F + V +C GY L GS + C W CK + C P Sbjct: 477 QLL----TKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPP 531 Query: 3079 TTANG--KVFRIDGTTFSSSVIYSCMEG------YILSGPSVRQCTAN----GTWSGTLP 3126 NG ++ + ++V Y+C G + L G S +CT+N GTWSG P Sbjct: 532 VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAP 591 Query: 3127 NCTI----ISCGDPGIPANGLRYGD---DYVVGQNVSYMCQPGYTMELNGSRIRTCTING 3179 C + + C I ANG + Y V++ C G+T L GS C + Sbjct: 592 LCKLSLLAVQCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYSGFT--LKGSSQIRCKADN 648 Query: 3180 TWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTC--VGNG 3237 TW +P C TC Q G+ + ++ C GY+L+ A C NG Sbjct: 649 TWDPEIPVCEKETCQHVRQSLQELPAGSRVE---LVNTSCQDGYQLTGHAYQMCQDAENG 705 Query: 3238 TWSGEVPQCLPKFCGDPGIPAQGKREG---KSFIYQSEVSFSCNFPFILVGSSTRICQAD 3294 W ++P C C P + GK G ++F+Y +EVS+ C+ F L+G C++D Sbjct: 706 IWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSD 765 Query: 3295 ----GTWSGSSPHCI-EPTQTSCENPGVPRHGSQNNT--FGFQVGSVVQFHCKKGHLLQG 3347 G+WSG SP C+ P T C NP V +HG + N + +V C G ++ G Sbjct: 766 SKGHGSWSGPSPQCLRSPPVTRCPNPEV-KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNG 824 Query: 3348 STTRTCLPDLTWSGIQPECIPHS---CKQPETPAHANVVGMDLP--SHGYTLIYTCQPGF 3402 S C D TW P CI + C P + N G ++ S G +++Y+C G+ Sbjct: 825 SRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGY 884 Query: 3403 FLAGGTEHRVCRSDNTWTGKVPICE 3427 L G +C + TW+ P C+ Sbjct: 885 LLV-GEALLLCTHEGTWSQPAPHCK 908 Score = 249 bits (635), Expect = 5e-65 Identities = 245/905 (27%), Positives = 368/905 (40%), Gaps = 157/905 (17%) Query: 2355 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413 C P + N +E+ G + Y C G+ LVG I+ C + PP C+ Sbjct: 154 CPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCE 211 Query: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQ 2473 E R S G +PN ++ KE +L+ Sbjct: 212 ------EARCKSLG---------RFPNGKV-----------------------KEPPILR 233 Query: 2474 VYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPE 2533 V N L G SS I G + W+ + +C +P Sbjct: 234 VGVTANFFCDEGYRLQGPPSSRCVIAGQG----VAWTKMPVCEE---------IFCPSPP 280 Query: 2534 SPPHGYIISQTGGQLN--SVVRWACDR------GFRLVGKSSAVCRKSSYGYHAWDAPVP 2585 +G I + ++ S+V + CD F L+G+S+ C S W P P Sbjct: 281 PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAP 340 Query: 2586 ACQ----AISCGIPKAPTNGGILTTD---YLVGTRVTYFCNDGYRLS-SKELTTAVCQSD 2637 C+ A+ C P+ G +++ Y V + C G+ L SK++ C + Sbjct: 341 RCELSTSAVQCPHPQI-LRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIR---CNAQ 396 Query: 2638 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI 2697 GTW P C C + + + +G+ + ++ T + +SC+PGY +G SI Sbjct: 397 GTWEP--SAPVCEK-ECQAPPNIL--NGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESI 451 Query: 2698 ECLPNGTWSWRNERPYCQIISCG----ELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVG 2753 +C G W+ P C++ +C +L T P + + +C G+ L G Sbjct: 452 QCTSEGVWT--PPVPQCKVAACEATGRQLLTKPQHQFVRPDVNS------SCGEGYKLSG 503 Query: 2754 SAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIG---ENYGYRDTVVYQCNPG---- 2806 S +EC + W C C P +I NG G E++ Y TV Y CNPG Sbjct: 504 SVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERG 563 Query: 2807 --FRLIGSSVRIC----QQDHNWSGQLPSC----VPVSCGHP----GSPIYGRTSGNGFN 2852 F LIG S C Q+ WSG P C + V C H G I G+ + + Sbjct: 564 VEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP--YF 621 Query: 2853 FNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNC-----SDPGIPANSKRESK 2907 +ND VTF C G+ ++G ++ +C+A+ W P+C+ C S +PA S+ E Sbjct: 622 YNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVE-- 679 Query: 2908 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQP--NGQWDKPLPECIMIDCGHPGVPPNAV 2965 +V C GY L G + +CQ NG W K +P C +I C P V N Sbjct: 680 ----------LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGK 729 Query: 2966 LSG---EKYTFGSTVHYSCTGKRSLLGQSSRTCQLN----GHWSGSQPHCSGDATGT-CG 3017 +G E + +G+ V Y C LLG+ C+ + G WSG P C T C Sbjct: 730 HTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP 789 Query: 3018 DPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KA- 3071 +P HG ++ S + V C+ G+I++GS C + +W P C KA Sbjct: 790 NPEVK-HGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAF 848 Query: 3072 VQCGNPGTTANGKVFRIDGTTFSS--SVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129 + C P T NG + FS S++YSC +GY+L G ++ CT GTWS P+C Sbjct: 849 IGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCK 908 Query: 3130 IISCGDP----GIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM 3185 ++C P GI GL Y G V+ C+ GY +E GS C + W+ + Sbjct: 909 EVNCSSPADMDGI-QKGLEPRKMYQYGAVVTLECEDGYMLE--GSPQSQCQSDHQWNPPL 965 Query: 3186 PTCRA 3190 CR+ Sbjct: 966 AVCRS 970 Score = 196 bits (499), Expect = 3e-49 Identities = 152/579 (26%), Positives = 240/579 (41%), Gaps = 89/579 (15%) Query: 2552 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDY--L 2609 ++++C+ G+ LVG+ S C W PVP C+ +C T +LT Sbjct: 435 IKYSCNPGYVLVGEESIQCTSEG----VWTPPVPQCKVAAC----EATGRQLLTKPQHQF 486 Query: 2610 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRI 2669 V V C +GY+LS CQ W + C +TCP I Sbjct: 487 VRPDVNSSCGEGYKLSGSVYQE--CQGTIPWFMEIRL--CKEITCPPPPV---------I 533 Query: 2670 VNGSH-------YEYKTKVVFSCDPG------YHGLGPASIECLPN----GTWSWRNERP 2712 NG+H + Y T V ++C+PG + +G ++I C N GTWS P Sbjct: 534 YNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWS--GPAP 591 Query: 2713 YCQI----ISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLGFMLVGSAVRECLSSGLW 2765 C++ + C + NG KI + + Y T F C GF L GS+ C + W Sbjct: 592 LCKLSLLAVQCSHVHIA-NGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTW 650 Query: 2766 SESETRCLAGHC-----GIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD 2820 C C + EL +V + V C G++L G + ++CQ Sbjct: 651 DPEIPVCEKETCQHVRQSLQELPAGSRV--------ELVNTSCQDGYQLTGHAYQMCQDA 702 Query: 2821 HN--WSGQLPSCVPVSCGHPGSPIYGRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQC 2875 N W ++P C + C P + G+ +G F + + V++ C+ G+ + G K QC Sbjct: 703 ENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC 762 Query: 2876 QANRQ----WSHPPPMC----KVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGY 2927 +++ + WS P P C V C +P + K H +++ +V+ DCNPG+ Sbjct: 763 RSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKT--HSAYSHNDIVYVDCNPGF 820 Query: 2928 FLFGSSVLICQPNGQWDKPLPECI---MIDCGHPGVPPNAVLSG---EKYTFGSTVHYSC 2981 + GS V+ C + W +P CI I C P PN +G +++ G ++ YSC Sbjct: 821 IMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSC 880 Query: 2982 TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYA 3041 L+G++ C G WS PHC + D G ++ + V Sbjct: 881 DQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLE 940 Query: 3042 CDTGYILHGSEERTCLANGSWTGRQPECKA-----VQCG 3075 C+ GY+L GS + C ++ W C++ V CG Sbjct: 941 CEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979 Score = 117 bits (294), Expect = 2e-25 Identities = 228/1044 (21%), Positives = 366/1044 (35%), Gaps = 181/1044 (17%) Query: 1825 FVYQAVPRTSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVP 1882 F+ P C S P GR AVG+ + + C+ + L G ++ C T Sbjct: 10 FLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKD 69 Query: 1883 NSLAQWNDSLPTC------------IVPCG----GILTKRKGTILSPGYPEPYDNNLN-C 1925 W+ P C IVP G G R G ++ + N N Sbjct: 70 KVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS 129 Query: 1926 VWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYS-GTTIPHLLNSTSNN 1984 VW ++ +L G + + +GS + G ++ + S + Sbjct: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTY---SCESG 186 Query: 1985 LYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSG------IKIGDRYMVGDVVSFQC 2038 L + I+ ++G +++A+ +C E + S G +K VG +F C Sbjct: 187 YLLVGEKIINCLSSG---KWSAVP-PTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFC 242 Query: 2039 DQGYSLQGHSHITCM-PGPVRRWNYPIPICLAQ-CGGAMSDFSGVILSPGFPGNYPSSLD 2096 D+GY LQG C+ G W +P+C C +G + S+ Sbjct: 243 DEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI- 300 Query: 2097 CTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHE 2156 T+T + GV+ + ST L S +T T SGP P ST+ Sbjct: 301 VTYTCDPDPEEGVNFILIGEST------LRCTVDSQKTGT----WSGPA-PRCELSTS-- 347 Query: 2157 TSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGND--FTVGQTISFECFPGY 2214 CP P+ R V G +T T+ F C G+ Sbjct: 348 ------------------------AVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGF 383 Query: 2215 TLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNG-------TIYSPGYPDEY---P 2264 TL G+ + C W P CE C +NG + PG +Y P Sbjct: 384 TLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441 Query: 2265 NF-----------QDCFWLVRVPPGNGIYINFT--VLQTEPIYDFITVWDGPDQNSPQIG 2311 + + W VP T L T+P + F+ PD NS G Sbjct: 442 GYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR----PDVNS-SCG 496 Query: 2312 QFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQ----PPPPV--PNAE 2365 + G SVY + F ++R+C+ PPPPV A Sbjct: 497 E--GYKLSGSVYQECQGTIPWF----------------MEIRLCKEITCPPPPVIYNGAH 538 Query: 2366 ILTEDDEFEIGDIIRYQCLPG------FTLVGNAILTCRLG--ERLQMDGAPPVCQVLCP 2417 + ++F G + Y C PG F+L+G + + C ER G P+C++ Sbjct: 539 TGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL--- 595 Query: 2418 ANELRLDSTGVILSPGYPDS--------YPNLQMCAWSISVEKGYNITMFVEFFQTEKEF 2469 + L + + V ++ GY S + +S KG + + E Sbjct: 596 -SLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEI 654 Query: 2470 DVLQVYDGPNIQSPVLISLSGDYSSAFNITS------NGHEVFLQWSADHGNNKKGFRIR 2523 V + +++ + +G N + GH + A++G K + Sbjct: 655 PVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 714 Query: 2524 YIAFYCSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2581 + +C P +G + V + CD+GF L+G+ CR S G+ +W Sbjct: 715 KV-IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773 Query: 2582 APVPAC----QAISCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQ 2635 P P C C P+ + T Y V CN G+ ++ + C Sbjct: 774 GPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIR--CH 831 Query: 2636 SDGTWSNHNKTPRCV---VVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2692 +D TW P C+ + CP +G N + + +++SCD GY + Sbjct: 832 TDNTWV--PGVPTCIKKAFIGCPPPPK--TPNGNHTGGNIARFSPGMSILYSCDQGYLLV 887 Query: 2693 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT----SYGSTAIFTCDLG 2748 G A + C GTWS P+C+ ++C P +G + G + YG+ C+ G Sbjct: 888 GEALLLCTHEGTWS--QPAPHCKEVNCSS-PADMDGIQKGLEPRKMYQYGAVVTLECEDG 944 Query: 2749 FMLVGSAVRECLSSGLWSESETRC 2772 +ML GS +C S W+ C Sbjct: 945 YMLEGSPQSQCQSDHQWNPPLAVC 968 Score = 99.0 bits (245), Expect = 8e-20 Identities = 78/276 (28%), Positives = 114/276 (41%), Gaps = 24/276 (8%) Query: 3184 VMPTCRAVTCPTPPQISNGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVG----NG 3237 V P ++C +PP I NGR+ T G I Y CS + L L C+ +G Sbjct: 14 VAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDG 73 Query: 3238 TWSGEVPQC--LPKF--CGDPGIPAQGKREGKS-FIYQSEVSFSCNFPFILVGSSTRICQ 3292 TW P+C K+ C +P +P K G + + + V+F+C F + G+ + CQ Sbjct: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133 Query: 3293 ADGTWSGSS-PHCIEPTQTSCENPGVPR----HGSQNNTFGFQVGSVVQFHCKKGHLLQG 3347 A+ W + P C+ C P +P H + N G V + C+ G+LL G Sbjct: 134 ANNMWGPTRLPTCVSVFPLEC--PALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVG 191 Query: 3348 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGG 3407 CL WS + P C CK + V + G T + C G+ L G Sbjct: 192 EKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251 Query: 3408 TEHR--VCRSDNTWTGKVPICEAGSKILVKDPRPAL 3441 R + WT K+P+CE +I P P L Sbjct: 252 PSSRCVIAGQGVAWT-KMPVCE---EIFCPSPPPIL 283 Score = 81.6 bits (200), Expect = 1e-14 Identities = 193/878 (21%), Positives = 300/878 (34%), Gaps = 183/878 (20%) Query: 1141 PCEDPGIPQY--GSRIGFNFGI---GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLP 1195 P E P +P G N G G ++T+SC SGY L G I CL G+ WSA P Sbjct: 151 PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPP 208 Query: 1196 RCV-AECGASATNNEGILLSP---------------NYPLNYENNHECIYSIQVQAGKGI 1239 C A C + G + P Y L + C+ + Q A + Sbjct: 209 TCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKM 268 Query: 1240 NISARTF------------------HLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLS 1281 + F +++ G ++ D + G S T+ Sbjct: 269 PVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVD 328 Query: 1282 STSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GYKISDQG--HFAGSTI 1337 S W G +L ++ + H PQ G +S Q + T+ Sbjct: 329 SQKTGTW-------SGPAPRCELSTSAVQCPH------PQILRGRMVSGQKDRYTYNDTV 375 Query: 1338 IYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGG---------------RFK-GE 1381 I+ C G+TL GS ++C + W+ P C EC RF G Sbjct: 376 IFACMFGFTLKGSKQIRC--NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGT 433 Query: 1382 SSGRILSPGYPFPYDNNLRC----MWMIEVDPGNIVSLQFLAFD--TEASHDILRVWDGP 1435 S +PGY + +++C +W V + + + T+ H +R P Sbjct: 434 SIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR----P 489 Query: 1436 PENDMLLK--EISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGV 1493 N + ++SGS+ E TI + + + K C P V Sbjct: 490 DVNSSCGEGYKLSGSVYQECQG------TIPWFMEIRLCKE-----------ITCPPPPV 532 Query: 1494 PMNGTRNGDGREP---GDTVVFQCDPG------YELQGEERITCIQVEN-RYFWQPSPPV 1543 NG G E G TV + C+PG + L GE I C + R W P+ Sbjct: 533 IYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPL 592 Query: 1544 C----IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1599 C +A ++ ++G+ +S PY ++ D V + F+++ + Sbjct: 593 CKLSLLAVQCSHVHIANGYKISGK-EAPYFYN-----------DTVTFKCYSGFTLKGSS 640 Query: 1600 DFLYIYDGP-DSNSPLIG---------SFQDSKLPERIESSSNTMHLAFRSDGSVSYTGF 1649 D D P+ S Q+ R+E + + ++ G Sbjct: 641 QIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQ 700 Query: 1650 HLEYKAKLRE-------SCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAGYVLQGYSTL 1699 E ++ C P I+NG GM ++ G+ V+Y CD G+ L G L Sbjct: 701 DAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKL 760 Query: 1700 TCIMGDDGRPGWNRALPSC-HAPCGSRSTGSEGTVLSPNYPKN---YSVGHNCVYSIAVP 1755 C G W+ P C +P +R E + Y N + HN + + Sbjct: 761 QCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE---VKHGYKLNKTHSAYSHNDIVYVDCN 817 Query: 1756 KEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLL-------SSLSGSHSGESLP-LSSGNQ 1807 F++ G V D V PT + +G+H+G ++ S G Sbjct: 818 PGFIMNGSRVI--RCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMS 875 Query: 1808 ITIR----FTSVGPITAKGFH--FVYQAVPRTSSTQCSSVPEPRFGRRIGNE----FAVG 1857 I + VG H Q P CSS P G + G E + G Sbjct: 876 ILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS-PADMDGIQKGLEPRKMYQYG 934 Query: 1858 SSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1895 + V +C GY+L GS +C+ S QWN L C Sbjct: 935 AVVTLECEDGYMLEGSPQSQCQ----SDHQWNPPLAVC 968 Score = 68.6 bits (166), Expect = 1e-10 Identities = 170/817 (20%), Positives = 277/817 (33%), Gaps = 159/817 (19%) Query: 1160 IGDTLTFSCSSGYRLEGTSEIICLGGGR--RVWSAPLPRCVAECGASATNNEGILLSPNY 1217 +G + +SCS +RL G ++C+ + W P P+C Sbjct: 43 VGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC-------------------- 82 Query: 1218 PLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRG 1277 Y N + V G I S H GD + T SM G Sbjct: 83 --EYFNKYSSCPEPIVPGGYKIRGSTPYRH---GDSV-----------TFACKTNFSMNG 126 Query: 1278 LTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQF--GYKISDQ-GHFA- 1333 + +W + N+ G + T + E P +P G+ S+ G A Sbjct: 127 ------NKSVWCQANNMW-----GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP 175 Query: 1334 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC-IAECG--GRFK----------- 1379 G ++ Y C GY L G ++ C++ + W P+C A C GRF Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCEEARCKSLGRFPNGKVKEPPILR 233 Query: 1380 -GESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP-- 1436 G ++ GY + RC +++ Q +A+ + + PP Sbjct: 234 VGVTANFFCDEGYRLQGPPSSRC----------VIAGQGVAWTKMPVCEEIFCPSPPPIL 283 Query: 1437 ----ENDMLLKEISGSLI--------PEGIHSTL---NIVTIQFDTDFYISKSGFAIQFS 1481 + L GS++ EG++ L + + D+ + SG A + Sbjct: 284 NGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCE 343 Query: 1482 -SSVATACRDPGVPMNGTRNG--DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQ 1538 S+ A C P + +G D DTV+F C G+ L+G ++I C + W+ Sbjct: 344 LSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC---NAQGTWE 400 Query: 1539 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVI----SLAFISFS 1594 PS PVC C +G H + N YV+ S+ S Sbjct: 401 PSAPVCEKECQAPPNILNG---QKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEG 457 Query: 1595 I-EPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSV-----SYTG 1648 + P + + L+ Q + + SS ++ GSV Sbjct: 458 VWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE---GYKLSGSVYQECQGTIP 514 Query: 1649 FHLEYKAKLRESCFDPGNIMNGTRLGM---DYKLGSTVTYYCDAG------YVLQGYSTL 1699 + +E + +C P I NG G D+ G+TVTY C+ G + L G ST+ Sbjct: 515 WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574 Query: 1700 TCIMGDDGRPGWNRALPSC------------HAPCGSRSTGSEGTVLSPNYPKNYSVGHN 1747 C D R W+ P C H G + +G E Y N +V Sbjct: 575 RCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP-----YFYNDTVTFK 629 Query: 1748 CVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPL----- 1802 C + + + + + V + T Q + SL +G + L Sbjct: 630 CYSGFTLKGSSQIRCK---ADNTWDPEIPVCEKETCQ-HVRQSLQELPAGSRVELVNTSC 685 Query: 1803 SSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG---NEFAVGSS 1859 G Q+T + G F + +P C P G+ G F G+ Sbjct: 686 QDGYQLTGHAYQMCQDAENGIWF--KKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNE 743 Query: 1860 VLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1896 V ++C+ G+ L G ++C + W+ P C+ Sbjct: 744 VSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780 Score = 62.8 bits (151), Expect = 6e-09 Identities = 102/447 (22%), Positives = 162/447 (36%), Gaps = 79/447 (17%) Query: 1678 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLSP 1736 ++G T ++CD GY LQG + C++ G W + +P C C S G + Sbjct: 233 RVGVTANFFCDEGYRLQGPPSSRCVIAGQG-VAWTK-MPVCEEIFCPSPPPILNGRHIG- 289 Query: 1737 NYPKNYSVGHNCVYSIAVPKE----FVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLS 1792 N N S G Y+ E F++ G+ T + GP + L +S Sbjct: 290 NSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349 Query: 1793 GSHSGESLP--LSSGNQI------TIRFTSVGPITAKGFHFV-------YQAVPRTSSTQ 1837 + L + SG + T+ F + T KG + ++ + Sbjct: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKE 409 Query: 1838 CSSVPEPRFGRRIGNE---FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894 C + P G++ F G+S+ + CNPGY+L G +I+C S W +P Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC----TSEGVWTPPVPQ 465 Query: 1895 C-IVPCGG----ILTKRKGTILSPG---------------YPE-----PYDNNLNCVWKI 1929 C + C +LTK + + P Y E P+ + +I Sbjct: 466 CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI 525 Query: 1930 TVPEGAGIQVQVVSFATEHNWDSLDFYDGGD------NNAPRLGSYSGTTIPHLLNSTSN 1983 T P V + H SL+ + G N P G + TSN Sbjct: 526 TCPP------PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579 Query: 1984 NLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDR---YMVGDVVSFQCDQ 2040 + + S A L A+ C ++G KI + Y D V+F+C Sbjct: 580 D---QERGTWSGPAPLCKLSLLAV---QCSHVHI-ANGYKISGKEAPYFYNDTVTFKCYS 632 Query: 2041 GYSLQGHSHITCMPGPVRRWNYPIPIC 2067 G++L+G S I C W+ IP+C Sbjct: 633 GFTLKGSSQIRCKAD--NTWDPEIPVC 657 Score = 59.7 bits (143), Expect = 5e-08 Identities = 142/694 (20%), Positives = 232/694 (33%), Gaps = 178/694 (25%) Query: 446 CPDPGEPENGKRIGSDF---SLGSTVQFSCDED------YVLQGAKSITCQRIAEVFAAW 496 CP P NG+ IG+ S GS V ++CD D ++L G ++ C ++ W Sbjct: 276 CPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTW 335 Query: 497 SDHRPVCKVKTC-----------GSNLQGPSGTFTSPN-------FPF------QYDSNA 532 S P C++ T G + G +T + F F Q NA Sbjct: 336 SGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNA 395 Query: 533 QCVWVITAVNTNKVIQ-----INFEEFD--------------------LEIGYDTLTIGD 567 Q W +A K Q +N ++ D + +G +++ Sbjct: 396 QGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTS 455 Query: 568 GGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN---YKEIE---- 620 G P +V +++ ++ + S G G+K++ Y+E + Sbjct: 456 EGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGE-GYKLSGSVYQECQGTIP 514 Query: 621 --------KE-SCGDPGTPLYGIREG---DGFSNRDVLRFECQFG------FELIGEKSI 662 KE +C P G G + F + + C G F LIGE +I Sbjct: 515 WFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTI 574 Query: 663 VCQENNQ----WSANIPIC-----IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIIS 713 C N+Q WS P+C C A + + P Y + + Sbjct: 575 RCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVT------- 627 Query: 714 DPGSRIHLSFNDFDLESQFDFLAVKDGD-SPESPILGTFTGAEVPSHLT-----SNSHIL 767 ++ F L+ D PE P+ T V L S ++ Sbjct: 628 ------FKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELV 681 Query: 768 RLEFQADHSMSGRGFNITYNTFGH-----------NECPDPGIPINARRFG---DNFQLG 813 Q + ++G + + + C P + +N + G +NF G Sbjct: 682 NTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYG 741 Query: 814 SSISVICEEGFIKTQGTETITCIL-MDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWP 872 + +S C++GF G + + C G WSG P+C S P +P Sbjct: 742 NEVSYECDQGFY-LLGEKKLQCRSDSKGHGSWSGPSPQCLR------SPPVTRCPNP--- 791 Query: 873 GYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQ 932 E + G+ + T + + D++ V P + NG++V Sbjct: 792 -------------EVKHGYKLNKTHSAYS---HNDIVYVDCNPGFI------MNGSRV-- 827 Query: 933 FLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD---FSIG 989 + TDN+ G + + C P +G G + FS G Sbjct: 828 ----------IRCHTDNTWV-PGVPTCIKKAFI---GCPPPPKTPNGNHTGGNIARFSPG 873 Query: 990 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023 ++ +SCD GY L E LLC WS P P C Sbjct: 874 MSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHC 907 Score = 59.3 bits (142), Expect = 7e-08 Identities = 188/892 (21%), Positives = 295/892 (33%), Gaps = 257/892 (28%) Query: 989 GSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALCGGDVRGPSGTILSP------ 1041 G +V++SC+SGY L E+ + C + WS PTC +A C R P+G + P Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235 Query: 1042 ---------GYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP 1092 GY P S C V G+GV + + + E P Sbjct: 236 VTANFFCDEGYRLQGPPSSRC-----VIAGQGVAWT-----------KMPVCEEIFCPSP 279 Query: 1093 LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGS 1152 PP +N GN A ++SY G +T Y +P + G+ Sbjct: 280 ---------PPILNGRHIGNSLA--------NVSY-GSIVT---YTCDPDPEEGV----- 313 Query: 1153 RIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGIL 1212 NF + T C+ + GT WS P PRC A + IL Sbjct: 314 ----NFILIGESTLRCTVDSQKTGT------------WSGPAPRCELSTSAVQCPHPQIL 357 Query: 1213 -------LSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--------IY 1257 Y N C++ ++ K I +A+ V + I Sbjct: 358 RGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNIL 417 Query: 1258 DGKDKTTHLLGAFTGASMR-----------GLTLSSTSNQLWL----------------- 1289 +G+ + H++ G S++ ++ TS +W Sbjct: 418 NGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQ 477 Query: 1290 ------------EFNS--------------DTEGTDEGFQLVYTSFELSHCEDPGIPQFG 1323 + NS + +GT F + E++ P I Sbjct: 478 LLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGA 537 Query: 1324 YKISDQGHFA-GSTIIYGCNPG------YTLHGSSLLKCMTG--ERRAWDYPLPSC---- 1370 + S F G+T+ Y CNPG ++L G S ++C + ER W P P C Sbjct: 538 HTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSL 597 Query: 1371 IAECGGRFKGESSGRILSPGYPFPYDNNL--RCMWMIEVDPGNIVSLQFLAFDTEASHDI 1428 +A + +I P+ Y++ + +C + F + S I Sbjct: 598 LAVQCSHVHIANGYKISGKEAPYFYNDTVTFKC---------------YSGFTLKGSSQI 642 Query: 1429 L----RVWDGPPENDMLLKE----ISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1480 WD PE + KE + SL S + +V + + +G A Q Sbjct: 643 RCKADNTWD--PEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQL--TGHAYQM 698 Query: 1481 SSSVATA-------------CRDPGVPMNGTRNGDGREP---GDTVVFQCDPGYELQGEE 1524 C P V +NG G E G+ V ++CD G+ L GE+ Sbjct: 699 CQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEK 758 Query: 1525 RITC-IQVENRYFWQ-------PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSR---- 1572 ++ C + W SPPV P N G+ L+ Y H+ Sbjct: 759 KLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP---NPEVKHGYKLNKTH-SAYSHNDIVYV 814 Query: 1573 DCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS-NSPLIGSFQDSKLPERIESSS 1631 DC+ +N VI + D ++ P IG K P + Sbjct: 815 DCNPGFIMNGSRVIRC---------HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGG 865 Query: 1632 NTMHLAFRSDGSVSYT---GFHLEYKAKL----------------RESCFDPGNIMNGTR 1672 N F S+ Y+ G+ L +A L +C P + M+G + Sbjct: 866 NIAR--FSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPAD-MDGIQ 922 Query: 1673 LGMD----YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1720 G++ Y+ G+ VT C+ GY+L+G C WN L C + Sbjct: 923 KGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC----QSDHQWNPPLAVCRS 970 Score = 48.1 bits (113), Expect = 2e-04 Identities = 137/667 (20%), Positives = 225/667 (33%), Gaps = 127/667 (19%) Query: 793 ECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 849 ECP + N +N G S++ CE G++ G + I C L GK WS + P Sbjct: 153 ECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV-GEKIINC-LSSGK--WSAVPP 208 Query: 850 KCG-APCGGHFSAPSGVILSP---------------GWPGYYKDSLNCEWVIEAEPGHSI 893 C A C P+G + P G+ S C + + Sbjct: 209 TCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKM 268 Query: 894 KITFERFQTELNYDVLEVHDGPNLLSPLLGS---YNGTQVPQFLFSSSNFIY-----LLF 945 + E F + H G +L + GS Y P+ NFI L Sbjct: 269 PVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE---EGVNFILIGESTLRC 325 Query: 946 TTDNSRSN--NGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD---FSIGSTVSFSCDSGY 1000 T D+ ++ +G E ++ + C P I + GR ++ TV F+C G+ Sbjct: 326 TVDSQKTGTWSGPAPRCE-LSTSAVQCPHPQI-LRGRMVSGQKDRYTYNDTVIFACMFGF 383 Query: 1001 RLSHEEPLLCEKNHWWSHPLPTCDALCGGD-------------VRGPSGTIL----SPGY 1043 L + + C W P C+ C VR GT + +PGY Sbjct: 384 TLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGY 443 Query: 1044 PEFYPNSLNCT----WTVDVTHGK--GVQFNFHTFHLEDHHDYLLITENGSFTQPLARLT 1097 S+ CT WT V K + + H ++ N S + +L+ Sbjct: 444 VLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGY-KLS 502 Query: 1098 GSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGF- 1156 GS +Y + + + + + E IT C P + G+ G Sbjct: 503 GS---------VYQECQGTIPWFMEIRLCKE---IT--------CPPPPVIYNGAHTGSS 542 Query: 1157 --NFGIGDTLTFSCSSG------YRLEGTSEIICLGGG--RRVWSAPLPRC-----VAEC 1201 +F G T+T++C+ G + L G S I C R WS P P C +C Sbjct: 543 LEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC 602 Query: 1202 GASATNNEGILLSPNYPLNYEN--NHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDG 1259 N + P Y + +C ++ I A + V + Sbjct: 603 SHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCE---- 658 Query: 1260 KDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS----------- 1308 K+ H+ S++ L S + + T +Q+ + Sbjct: 659 KETCQHV-----RQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPL 713 Query: 1309 FELSHCEDPGIPQFGYK--ISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGER--RAWD 1364 ++ HC P + G + + G+ + Y C+ G+ L G L+C + + +W Sbjct: 714 CKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773 Query: 1365 YPLPSCI 1371 P P C+ Sbjct: 774 GPSPQCL 780 Score = 45.1 bits (105), Expect = 0.001 Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 7/75 (9%) Query: 439 IKTASNLCPDPGEPENGKRIGSD---FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAA 495 IK A CP P + NG G + FS G ++ +SCD+ Y+L G + C Sbjct: 844 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTH----EGT 899 Query: 496 WSDHRPVCKVKTCGS 510 WS P CK C S Sbjct: 900 WSQPAPHCKEVNCSS 914 Score = 43.9 bits (102), Expect = 0.003 Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 34/252 (13%) Query: 1666 NIMNGTRLG---MDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPC 1722 +I NG ++ Y TVT+ C +G+ L+G S + C + W+ +P C Sbjct: 606 HIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNT----WDPEIPVCEKET 661 Query: 1723 GSR--------STGSEGTVLSPNYPKNYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLHD 1773 GS +++ + Y + GH Y + E ++ + + +H Sbjct: 662 CQHVRQSLQELPAGSRVELVNTSCQDGYQLTGH--AYQMCQDAENGIWFKKIPLCKVIHC 719 Query: 1774 ------VVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827 V + G ++ L + + L ++ R S G + G Sbjct: 720 HPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS--P 777 Query: 1828 QAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSS---VLFDCNPGYILHGSIAIRCETVPNS 1884 Q + T+C + PE + G ++ + S V DCNPG+I++GS IRC T Sbjct: 778 QCLRSPPVTRCPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT- 835 Query: 1885 LAQWNDSLPTCI 1896 W +PTCI Sbjct: 836 ---WVPGVPTCI 844 Score = 43.1 bits (100), Expect = 0.005 Identities = 23/54 (42%), Positives = 28/54 (51%), Gaps = 5/54 (9%) Query: 153 RFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMR 206 RFD G I+YSC GY+L G + C + V W PVP C+ AC T R Sbjct: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGV----WTPPVPQCKVA-ACEATGR 476 Score = 42.4 bits (98), Expect = 0.009 Identities = 24/61 (39%), Positives = 28/61 (45%), Gaps = 2/61 (3%) Query: 137 SCGNPGVPPKGVL--YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 SCG+P G + Y T VG IRYSC + L G L CI +WD P P Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81 Query: 195 C 195 C Sbjct: 82 C 82 Score = 42.4 bits (98), Expect = 0.009 Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 2/58 (3%) Query: 623 SCGDPGTPL-YGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWS-ANIPICI 678 SC +P P Y IR + + D + F C+ F + G KS+ CQ NN W +P C+ Sbjct: 90 SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCV 147 Score = 42.4 bits (98), Expect = 0.009 Identities = 54/262 (20%), Positives = 91/262 (34%), Gaps = 42/262 (16%) Query: 446 CPDPGEPENGKRIG---SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502 C P NGK G +F G+ V + CD+ + L G K + C+ ++ +WS P Sbjct: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778 Query: 503 CKVKTCGSNLQGPSGT-FTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561 C L+ P T +P Y N +A + N ++ ++ + G Sbjct: 779 C--------LRSPPVTRCPNPEVKHGYKLNK----THSAYSHNDIVYVDCNPGFIMNGSR 826 Query: 562 TLTIGDGGE--VGDPRTVLQVLTGSFVPDL----------IVSMSSQMWLHLQTDESVGS 609 + G P + + G P I S M + D+ Sbjct: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL 886 Query: 610 VGFKV--------------NYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFE 655 VG + + KE+ S D G+ + V+ EC+ G+ Sbjct: 887 VGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM 946 Query: 656 LIGEKSIVCQENNQWSANIPIC 677 L G CQ ++QW+ + +C Sbjct: 947 LEGSPQSQCQSDHQWNPPLAVC 968 Score = 38.9 bits (89), Expect = 0.095 Identities = 60/261 (22%), Positives = 98/261 (37%), Gaps = 36/261 (13%) Query: 1660 SCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717 SC P I+NG + +G+ + Y C + L G +L CI D W++ P Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81 Query: 1718 CH------------APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQF- 1764 C P G + G S Y SV C + ++ V+ Q Sbjct: 82 CEYFNKYSSCPEPIVPGGYKIRG------STPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135 Query: 1765 -VFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF 1823 ++ T L V V+ P + +L +G H+ E++ S +++ ++ G Sbjct: 136 NMWGPTRLPTCVSVF--PLECPALPMIHNGHHTSENVG-SIAPGLSVTYSCESGYLLVGE 192 Query: 1824 HFV-------YQAVPRT-SSTQCSSVPE-PRFGRRIGNEFAVGSSVLFDCNPGYILHGSI 1874 + + AVP T +C S+ P + VG + F C+ GY L G Sbjct: 193 KIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPP 252 Query: 1875 AIRCETVPNSLAQWNDSLPTC 1895 + RC +A W +P C Sbjct: 253 SSRCVIAGQGVA-WT-KMPVC 271 Score = 37.7 bits (86), Expect = 0.21 Identities = 74/300 (24%), Positives = 108/300 (36%), Gaps = 61/300 (20%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C G NGK + +G T F CDE Y LQG S C IA AW+ PVC+ Sbjct: 215 CKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCV-IAGQGVAWT-KMPVCE 272 Query: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVIT-AVNTNKVIQINFEEFDLEIGYDTL 563 C S +G + +N ++T + + +NF + IG TL Sbjct: 273 EIFCPSPPPILNGRHIGNSL-----ANVSYGSIVTYTCDPDPEEGVNF----ILIGESTL 323 Query: 564 TIG-DGGEVGD-----PRTVL----------QVLTGSFVPDLIVSMSSQMWLHLQTDESV 607 D + G PR L Q+L G V S Q + D + Sbjct: 324 RCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV-------SGQKDRYTYNDTVI 376 Query: 608 GSVGFKVNYKEIEKESCGDPGT--PLYGIREGD----------GFSNRDVLRFE------ 649 + F K ++ C GT P + E + +R ++RF+ Sbjct: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIK 436 Query: 650 --CQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSN----FTAPMGTVLSPDYPEGYG 702 C G+ L+GE+SI C W+ +P C + C + T P + PD G Sbjct: 437 YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCG 496 Score = 35.8 bits (81), Expect = 0.80 Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 6/62 (9%) Query: 969 SCLDPGIPVHGR--RYGHDFSIGSTVSFSCDSGYRLSHEEPLLC----EKNHWWSHPLPT 1022 SC P ++GR Y ++G+ + +SC +RL E+ LLC + + W P P Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81 Query: 1023 CD 1024 C+ Sbjct: 82 CE 83 Score = 35.8 bits (81), Expect = 0.80 Identities = 56/279 (20%), Positives = 105/279 (37%), Gaps = 63/279 (22%) Query: 1134 FSEYNLEPCEDPGIPQ-YGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWS- 1191 F++Y+ C +P +P Y R + GD++TF+C + + + G + C +W Sbjct: 85 FNKYS--SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC--QANNMWGP 140 Query: 1192 APLPRCVA----ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFH 1247 LP CV+ EC P P+ + +H + G + S + + Sbjct: 141 TRLPTCVSVFPLEC-------------PALPMIHNGHHTSENVGSIAPGLSVTYSCESGY 187 Query: 1248 LAQGD--VLKIYDGK---------DKTTHLLGAFTGASMR-------GLTLSSTSNQLW- 1288 L G+ + + GK + LG F ++ G+T + ++ + Sbjct: 188 LLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYR 247 Query: 1289 LEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP---------QFGYKISDQGHFAGSTIIY 1339 L+ + G + +T + CE+ P G +++ + GS + Y Sbjct: 248 LQGPPSSRCVIAGQGVAWTKMPV--CEEIFCPSPPPILNGRHIGNSLANVSY--GSIVTY 303 Query: 1340 GCNP------GYTLHGSSLLKCMTGERR--AWDYPLPSC 1370 C+P + L G S L+C ++ W P P C Sbjct: 304 TCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRC 342 Score = 35.8 bits (81), Expect = 0.80 Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 7/62 (11%) Query: 138 CGNPGVPPKGVLYG---TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 C P P G G RF G I YSC GY+L G L C + +W P P Sbjct: 851 CPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLC----THEGTWSQPAPH 906 Query: 195 CR 196 C+ Sbjct: 907 CK 908 Score = 35.8 bits (81), Expect = 0.80 Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 6/49 (12%) Query: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC------DALCG 1028 + G+ V+ C+ GY L C+ +H W+ PL C LCG Sbjct: 931 YQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCG 979 Score = 35.0 bits (79), Expect = 1.4 Identities = 25/81 (30%), Positives = 36/81 (44%), Gaps = 9/81 (11%) Query: 446 CPDPGEPENG----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501 CP NG + +GS + G +V +SC+ Y+L G K I C + WS P Sbjct: 154 CPALPMIHNGHHTSENVGS-IAPGLSVTYSCESGYLLVGEKIINCLSSGK----WSAVPP 208 Query: 502 VCKVKTCGSNLQGPSGTFTSP 522 C+ C S + P+G P Sbjct: 209 TCEEARCKSLGRFPNGKVKEP 229 Score = 35.0 bits (79), Expect = 1.4 Identities = 19/49 (38%), Positives = 25/49 (51%), Gaps = 1/49 (2%) Query: 648 FECQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSNFTAPMGTVLSP 695 + C+ G+ L+GEK I C + +WSA P C C S P G V P Sbjct: 181 YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEP 229 Score = 34.7 bits (78), Expect = 1.8 Identities = 15/42 (35%), Positives = 22/42 (52%) Query: 154 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195 F G+++ Y C G+ L G +L C ++S SW P P C Sbjct: 738 FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQC 779 Score = 33.1 bits (74), Expect = 5.2 Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 4/67 (5%) Query: 131 EELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 +E+ SS + KG+ + G + C GY+L+G PQ C ++ W+ Sbjct: 908 KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH----QWNP 963 Query: 191 PVPICRA 197 P+ +CR+ Sbjct: 964 PLAVCRS 970 Score = 32.3 bits (72), Expect = 8.9 Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 1/49 (2%) Query: 136 SSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSV 183 SSC P VP + G T + GD + ++C T + ++G+ + C AN++ Sbjct: 89 SSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137 Score = 32.3 bits (72), Expect = 8.9 Identities = 16/43 (37%), Positives = 24/43 (55%), Gaps = 1/43 (2%) Query: 446 CPDPGEPENGKRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQ 487 CP+P P K GS + G +V F+C ++ + G KS+ CQ Sbjct: 91 CPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133 >gi|157419154 selectin P precursor [Homo sapiens] Length = 830 Score = 258 bits (660), Expect = 6e-68 Identities = 163/561 (29%), Positives = 248/561 (44%), Gaps = 46/561 (8%) Query: 2669 IVNGSH----YEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPT 2724 ++N SH + + ++ F C GY GP+ +ECL +G W+ N+ P C C L Sbjct: 210 LMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT--NKPPQCLAAQCPPLKI 267 Query: 2725 PPNGNKIGTQTS----YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIP 2780 P GN ++ + S+ F+C+ GF LVG V +C +SG+W+ C A C Sbjct: 268 PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHL 327 Query: 2781 ELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG 2836 E G + + + Y + ++C PG+R+ G + C +WS LP+C +SC Sbjct: 328 EAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCE 387 Query: 2837 HPGSPIYG----RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVN 2892 SP++G S F ++ +F C G++++G +C QW+ P P+C+ + Sbjct: 388 PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQ 447 Query: 2893 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIM 2952 C D +P ++ G F Y +V + CN G L G+SVL C G W+ PEC Sbjct: 448 CQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQA 507 Query: 2953 IDCGHPGVPPNAVLSGEK----YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3008 I C P N ++ + ++ ST + C SL G C +G W+ S P C Sbjct: 508 IPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMC 567 Query: 3009 SGDATGTCGDPGTPGHGSRQESN----FRTKSTVRYACDTGYILHGSEERTCLANGSWTG 3064 C + P GS S+ F ST ++CD G+ L G C +G W+ Sbjct: 568 EAI---KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSA 624 Query: 3065 RQPECK--------AVQCGNPGTTANGKVF--RIDGT-TFSSSVIYSCMEGYILSGPSVR 3113 P CK VQC T G ++ GT F+++ + C G+ L G S Sbjct: 625 TPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTL 684 Query: 3114 QCTANGTWSGTLPNCTIISCGD----PGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG 3169 C +G W+ P C + C + I N ++ G S+ C G LNG Sbjct: 685 SCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQL--LNG 742 Query: 3170 SRIRTCTINGTWSGVMPTCRA 3190 S C NG WS +PTC+A Sbjct: 743 SAQTACQENGHWSTTVPTCQA 763 Score = 242 bits (617), Expect = 6e-63 Identities = 164/579 (28%), Positives = 241/579 (41%), Gaps = 59/579 (10%) Query: 2826 QLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP 2885 +LP V ++C HP GN F+FN +F C GY + GP+K +C A+ W++ P Sbjct: 204 ELPQHVLMNCSHP--------LGN-FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKP 254 Query: 2886 PMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDK 2945 P C C IP F + + + C G+ L G V+ C +G W Sbjct: 255 PQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTA 314 Query: 2946 PLPECIMIDCGHPGVPPNAVLSG----EKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW 3001 P P C + C H P + + +GS+ + C + G C +GHW Sbjct: 315 PAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHW 374 Query: 3002 SGSQPHCSGDATGTCGDPGTPGHGSRQESN----FRTKSTVRYACDTGYILHGSEERTCL 3057 S P C + C +P HGS S F+ + + C G++L G++ C Sbjct: 375 SAPLPTCEAIS---CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCD 431 Query: 3058 ANGSWTGRQPECKAVQCGNPGTTANGKV---FRIDGTTFSSSVIYSCMEGYILSGPSVRQ 3114 G WT P C+A+QC + +V + S ++C EG +L G SV Q Sbjct: 432 NLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ 491 Query: 3115 CTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQPGYTMELNGS 3170 C A G W+ P C I C P NG ++ ++C GY+ L+G Sbjct: 492 CLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYS--LSGP 549 Query: 3171 RIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN----FDWGFSISYICSPGYELS 3226 CT +G W+ P C A+ CP G L+ ++ F+ G + + C G++L Sbjct: 550 ERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE 609 Query: 3227 FPAVLTCVGNGTWSGEVPQC-----LPKFCGDPGI-------PAQG----KREGKSFIYQ 3270 P + C +G WS P C LP PG+ P QG + +F + Sbjct: 610 GPNNVECTTSGRWSATPPTCKGIASLPT----PGVQCPALTTPGQGTMYCRHHPGTFGFN 665 Query: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN--NTFG 3328 + F CN F L+G ST C+ G W+ +P C C V + + N N +G Sbjct: 666 TTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC---RAVKCSELHVNKPIAMNCSNLWG 722 Query: 3329 -FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC 3366 F GS+ FHC +G LL GS C + WS P C Sbjct: 723 NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761 Score = 239 bits (609), Expect = 5e-62 Identities = 170/612 (27%), Positives = 251/612 (41%), Gaps = 83/612 (13%) Query: 2684 SCDPGYHGLGPASIECLPNGTWSWRNERPYCQII-SCGELPTPPN-----GNKIGTQTSY 2737 SC PG++G P C+ + CGEL P + + +G S+ Sbjct: 184 SCYPGFYG--------------------PECEYVRECGELELPQHVLMNCSHPLGN-FSF 222 Query: 2738 GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVI----GENY 2793 S F C G+ + G + ECL+SG+W+ +CLA C ++ G + + + Sbjct: 223 NSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAF 282 Query: 2794 GYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG----N 2849 ++ + + C GF L+G V C W+ P C V C H +P G Sbjct: 283 QHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLT 342 Query: 2850 GFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIE 2909 F + F C GY ++G +C + WS P P C+ ++C P + + Sbjct: 343 AFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPS 402 Query: 2910 HGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGE 2969 F Y T + C G+ L G+ ++ C GQW P P C + C VP A ++ Sbjct: 403 LRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCS 462 Query: 2970 ----KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSG----------DATGT 3015 + + S ++C L+G S C G+W+ P C + T T Sbjct: 463 HPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMT 522 Query: 3016 CGDP-GTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQC 3074 C P G+ + KST ++ CD GY L G E C +G WT P C+A++C Sbjct: 523 CVQPLGSSSY----------KSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKC 572 Query: 3075 GNPGTTANGKVFRIDGT---TFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT-I 3130 G + D S+ +SC G+ L GP+ +CT +G WS T P C I Sbjct: 573 PELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGI 632 Query: 3131 ISCGDPGI-------PANGLRYGDDY--VVGQNVS--YMCQPGYTMELNGSRIRTCTING 3179 S PG+ P G Y + G N + + C G+T L G +C +G Sbjct: 633 ASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFT--LIGDSTLSCRPSG 690 Query: 3180 TWSGVMPTCRAVTCP-----TPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCV 3234 W+ V P CRAV C P ++ L G NF +G S+ C G L+ A C Sbjct: 691 QWTAVTPACRAVKCSELHVNKPIAMNCSNLWG-NFSYGSICSFHCLEGQLLNGSAQTACQ 749 Query: 3235 GNGTWSGEVPQC 3246 NG WS VP C Sbjct: 750 ENGHWSTTVPTC 761 Score = 226 bits (575), Expect = 4e-58 Identities = 153/549 (27%), Positives = 231/549 (42%), Gaps = 42/549 (7%) Query: 2792 NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRT----S 2847 N+ + + C G+++ G S C W+ + P C+ C P G S Sbjct: 219 NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278 Query: 2848 GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESK 2907 F +FSC G+ + GP QC A+ W+ P P+CK V C P+ + Sbjct: 279 AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCV 338 Query: 2908 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL- 2966 F YG+ ++C PGY + G +L C +G W PLP C I C P + + Sbjct: 339 HPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMD 398 Query: 2967 ---SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPG 3023 S + + + + C L G C G W+ P C C D P Sbjct: 399 CSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQ---ALQCQDLPVPN 455 Query: 3024 HG----SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGT 3079 S FR +S + C+ G +L G+ CLA G+W PEC+A+ C + Sbjct: 456 EARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLS 515 Query: 3080 TANGK---VFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDP 3136 NG V + +++ S+ + C EGY LSGP CT +G W+ + P C I C + Sbjct: 516 PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL 575 Query: 3137 GIPANG-LRYGD---DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV- 3191 P G L D ++ VG + C G+ +E G CT +G WS PTC+ + Sbjct: 576 FAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE--GPNNVECTTSGRWSATPPTCKGIA 633 Query: 3192 TCPTP----PQISNGRLEGTNF------DWGFSIS--YICSPGYELSFPAVLTCVGNGTW 3239 + PTP P ++ +GT + +GF+ + + C+ G+ L + L+C +G W Sbjct: 634 SLPTPGVQCPALTTPG-QGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQW 692 Query: 3240 SGEVPQCLPKFCGD----PGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADG 3295 + P C C + I +F Y S SF C +L GS+ CQ +G Sbjct: 693 TAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENG 752 Query: 3296 TWSGSSPHC 3304 WS + P C Sbjct: 753 HWSTTVPTC 761 Score = 216 bits (550), Expect = 3e-55 Identities = 144/519 (27%), Positives = 220/519 (42%), Gaps = 50/519 (9%) Query: 2525 IAFYCSTPESPPHGYII---SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2581 +A C + P G + S Q S ++C+ GF LVG C S W Sbjct: 258 LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG----VWT 313 Query: 2582 APVPACQAISCGIPKAPTNGGI----LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSD 2637 AP P C+A+ C +AP+ G + T + G+ + C GYR+ ++ C Sbjct: 314 APAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLR--CIDS 371 Query: 2638 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH-YEYKTKVVFSCDPGYHGLGPAS 2696 G WS P C ++C + S + HG ++Y T F C G+ G Sbjct: 372 GHWS--APLPTCEAISCEPLESPV--HGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADI 427 Query: 2697 IECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYG-----STAIFTCDLGFML 2751 + C + W P CQ + C +LP PN ++ +G S FTC+ G +L Sbjct: 428 VRC--DNLGQWTAPAPVCQALQCQDLPV-PNEARVNCSHPFGAFRYQSVCSFTCNEGLLL 484 Query: 2752 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG-----QVIGENYGYRDTVVYQCNPG 2806 VG++V +CL++G W+ C A C NG Q +G + Y+ T + C+ G Sbjct: 485 VGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS-SYKSTCQFICDEG 543 Query: 2807 FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGR-----TSGNGFNFNDVVTFSC 2861 + L G C + W+ P C + C +P G T G FN FSC Sbjct: 544 YSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGE-FNVGSTCHFSC 602 Query: 2862 NIGYLMQGPTKAQCQANRQWSHPPPMCK-VVNCSDPGI-------PANSKRESKIEHGNF 2913 + G+ ++GP +C + +WS PP CK + + PG+ P + G F Sbjct: 603 DNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTF 662 Query: 2914 TYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCG----HPGVPPNAVLSGE 2969 + T ++ CN G+ L G S L C+P+GQW P C + C + + N Sbjct: 663 GFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWG 722 Query: 2970 KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3008 +++GS + C + L G + CQ NGHWS + P C Sbjct: 723 NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761 Score = 202 bits (515), Expect = 4e-51 Identities = 167/643 (25%), Positives = 257/643 (39%), Gaps = 82/643 (12%) Query: 2829 SCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP-PM 2887 SC +SC G + T GN T SC G+ GP +C+ R+ P Sbjct: 162 SCQDMSCSKQGECL--ETIGN-------YTCSCYPGFY--GP---ECEYVRECGELELPQ 207 Query: 2888 CKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPL 2947 ++NCS P GNF++ + + C GY + G S L C +G W Sbjct: 208 HVLMNCSHP-------------LGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKP 254 Query: 2948 PECIMIDCGHPGVPPNAVL----SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSG 3003 P+C+ C +P + S + + S+ +SC +L+G C +G W+ Sbjct: 255 PQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTA 314 Query: 3004 SQPHCSGDATGTCGDPGTPGHGSRQ----ESNFRTKSTVRYACDTGYILHGSEERTCLAN 3059 P C C P G+ + F S+ ++ C GY + G + C+ + Sbjct: 315 PAPVCKAVQ---CQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDS 371 Query: 3060 GSWTGRQPECKAVQCGNPGTTANGKVF---RIDGTTFSSSVIYSCMEGYILSGPSVRQCT 3116 G W+ P C+A+ C + +G + + + ++ + C EG++L G + +C Sbjct: 372 GHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCD 431 Query: 3117 ANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVG----QNV-SYMCQPGYTMELNGSR 3171 G W+ P C + C D +P N R + G Q+V S+ C G + L G+ Sbjct: 432 NLGQWTAPAPVCQALQCQDLPVP-NEARVNCSHPFGAFRYQSVCSFTCNEG--LLLVGAS 488 Query: 3172 IRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGT----NFDWGFSISYICSPGYELSF 3227 + C G W+ V P C+A+ C NG + + + + +IC GY LS Sbjct: 489 VLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSG 548 Query: 3228 PAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKS----FIYQSEVSFSCNFPFIL 3283 P L C +G W+ P C C + P QG + F S FSC+ F L Sbjct: 549 PERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKL 608 Query: 3284 VGSSTRICQADGTWSGSSPHCIEPTQTSCENPGV-------PRHGSQN-----NTFGFQV 3331 G + C G WS + P C S PGV P G+ TFGF Sbjct: 609 EGPNNVECTTSGRWSATPPTC--KGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFN- 665 Query: 3332 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ-----PETPAHANVVGMD 3386 + F C G L G +T +C P W+ + P C C + P +N+ G Sbjct: 666 -TTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNF 724 Query: 3387 LPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAG 3429 S+G + C G L G+ C+ + W+ VP C+AG Sbjct: 725 --SYGSICSFHCLEGQLL-NGSAQTACQENGHWSTTVPTCQAG 764 Score = 196 bits (497), Expect = 5e-49 Identities = 145/553 (26%), Positives = 228/553 (41%), Gaps = 42/553 (7%) Query: 2549 NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD- 2607 NS + C G+++ G S C S W P C A C K P G + Sbjct: 223 NSQCSFHCTDGYQVNGPSKLECLASGI----WTNKPPQCLAAQCPPLKIPERGNMTCLHS 278 Query: 2608 ---YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEH 2664 + + ++ C +G+ L E+ C + G W+ P C V C + + Sbjct: 279 AKAFQHQSSCSFSCEEGFALVGPEVVQ--CTASGVWTA--PAPVCKAVQCQHLEA--PSE 332 Query: 2665 GRWRIVNG-SHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2723 G V+ + + Y + F C PGY G + C+ +G WS P C+ ISC L Sbjct: 333 GTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWS--APLPTCEAISCEPLE 390 Query: 2724 TPPNGNKIGTQT----SYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCG- 2778 +P +G+ + + Y + F C GFML G+ + C + G W+ C A C Sbjct: 391 SPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450 Query: 2779 --IP-ELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSC 2835 +P E VN + Y+ + CN G L+G+SV C NW+ P C + C Sbjct: 451 LPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPC 510 Query: 2836 GHPGSPIYGRTSG----NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVV 2891 SP G + ++ F C+ GY + GP + C + +W+ PPMC+ + Sbjct: 511 TPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAI 570 Query: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951 C + P + G F G+ + C+ G+ L G + + C +G+W P C Sbjct: 571 KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCK 630 Query: 2952 MI-DCGHPGVPPNAVLS---GEKY------TFG--STVHYSCTGKRSLLGQSSRTCQLNG 2999 I PGV A+ + G Y TFG +T ++ C +L+G S+ +C+ +G Sbjct: 631 GIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSG 690 Query: 3000 HWSGSQPHCSGDATGTCG-DPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3058 W+ P C + + S NF S + C G +L+GS + C Sbjct: 691 QWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQE 750 Query: 3059 NGSWTGRQPECKA 3071 NG W+ P C+A Sbjct: 751 NGHWSTTVPTCQA 763 Score = 151 bits (381), Expect = 1e-35 Identities = 116/394 (29%), Positives = 161/394 (40%), Gaps = 44/394 (11%) Query: 2526 AFYCSTPESPPHGYII---SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDA 2582 A C ESP HG + S Q ++ + C GF L G C W A Sbjct: 383 AISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ----WTA 438 Query: 2583 PVPACQAISCGIPKAPTNGGILTTDYLVGTRV----TYFCNDGYRLSSKELTTAVCQSDG 2638 P P CQA+ C P + + R ++ CN+G L + C + G Sbjct: 439 PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ--CLATG 496 Query: 2639 TWSNHNKTPRCVVVTCPSINSFILEHGRWRIVN--GSHYEYKTKVVFSCDPGYHGLGPAS 2696 W++ P C + C + S ++G V GS YK+ F CD GY GP Sbjct: 497 NWNS--VPPECQAIPCTPLLS--PQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPER 551 Query: 2697 IECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT----SYGSTAIFTCDLGFMLV 2752 ++C +G W+ + P C+ I C EL P G+ + T + GST F+CD GF L Sbjct: 552 LDCTRSGRWT--DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE 609 Query: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPE-------LIVNGQVI------GENYGYRDTV 2799 G EC +SG WS + C G +P L GQ +G+ T Sbjct: 610 GPNNVECTTSGRWSATPPTC-KGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTC 668 Query: 2800 VYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG--HPGSPIYGRTSG--NGFNFND 2855 + CN GF LIG S C+ W+ P+C V C H PI S F++ Sbjct: 669 YFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGS 728 Query: 2856 VVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2889 + +F C G L+ G + CQ N WS P C+ Sbjct: 729 ICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762 Score = 97.4 bits (241), Expect = 2e-19 Identities = 75/278 (26%), Positives = 119/278 (42%), Gaps = 32/278 (11%) Query: 2526 AFYCSTPESPPHGYI--ISQTGGQ-LNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDA 2582 A C+ SP +G + + G S ++ CD G+ L G C +S W Sbjct: 507 AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSG----RWTD 562 Query: 2583 PVPACQAISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDG 2638 P C+AI C AP G + +D + VG+ + C++G++L C + G Sbjct: 563 SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPN--NVECTTSG 620 Query: 2639 TWSNHNKTPRCVV------VTCPSINSFILEHGRWRIVNGSH---YEYKTKVVFSCDPGY 2689 WS T + + V CP++ + G+ + H + + T F C+ G+ Sbjct: 621 RWSATPPTCKGIASLPTPGVQCPALTT----PGQGTMYCRHHPGTFGFNTTCYFGCNAGF 676 Query: 2690 HGLGPASIECLPNGTWSWRNERPYCQIISCGEL----PTPPNGNKIGTQTSYGSTAIFTC 2745 +G +++ C P+G W+ P C+ + C EL P N + + SYGS F C Sbjct: 677 TLIGDSTLSCRPSGQWT--AVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734 Query: 2746 DLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELI 2783 G +L GSA C +G WS + C AG I E + Sbjct: 735 LEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEAL 772 Score = 70.5 bits (171), Expect = 3e-11 Identities = 50/189 (26%), Positives = 77/189 (40%), Gaps = 10/189 (5%) Query: 3266 SFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQ-- 3323 +F + S+ SF C + + G S C A G W+ P C+ C +P G+ Sbjct: 219 NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLA---AQCPPLKIPERGNMTC 275 Query: 3324 -NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHAN- 3381 ++ FQ S F C++G L G C W+ P C C+ E P+ Sbjct: 276 LHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM 335 Query: 3382 --VVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRP 3439 V + ++G + + CQPG+ + G R C W+ +P CEA S ++ P Sbjct: 336 DCVHPLTAFAYGSSCKFECQPGYRVRGLDMLR-CIDSGHWSAPLPTCEAISCEPLESPVH 394 Query: 3440 ALGTPSPKL 3448 SP L Sbjct: 395 GSMDCSPSL 403 Score = 64.3 bits (155), Expect = 2e-09 Identities = 111/485 (22%), Positives = 171/485 (35%), Gaps = 123/485 (25%) Query: 793 ECPDPGIP----INARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 848 +CP IP + FQ SS S CEEGF G E + C +W+ Sbjct: 261 QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALV-GPEVVQCTASG---VWTAPA 316 Query: 849 PKCGAPCGGHFSAPSGVILSPGWP-GYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYD 907 P C A H APS + P + +C++ E +PG+ ++ D Sbjct: 317 PVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKF--ECQPGYRVR----------GLD 364 Query: 908 VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 967 +L D + +PL T Sbjct: 365 MLRCIDSGHWSAPL-----------------------------------------PTCEA 383 Query: 968 YSCLDPGIPVHGRRYGHD----FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023 SC PVHG F + SF C G+ L + + C+ W+ P P C Sbjct: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443 Query: 1024 DALCGGDVRGPSGTILSPGYP--EFYPNSLNCTWTVD---VTHGKGV-----QFNFHTFH 1073 AL D+ P+ ++ +P F S+ C++T + + G V N+++ Sbjct: 444 QALQCQDLPVPNEARVNCSHPFGAFRYQSV-CSFTCNEGLLLVGASVLQCLATGNWNSVP 502 Query: 1074 LEDHH---DYLLITENGSFT--QPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE 1128 E LL +NG+ T QPL ++++ +FI D S Sbjct: 503 PECQAIPCTPLLSPQNGTMTCVQPLGS---------------SSYKSTCQFICDEGYSLS 547 Query: 1129 G---FNITFS-EYNLEP-------CEDPGIPQYGSR----IGFNFGIGDTLTFSCSSGYR 1173 G + T S + P C + P+ GS F +G T FSC +G++ Sbjct: 548 GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607 Query: 1174 LEGTSEIICLGGGRRVWSAPLPRCV---------AECGASATNNEGILLSPNYPLNYENN 1224 LEG + + C GR WSA P C +C A T +G + ++P + N Sbjct: 608 LEGPNNVECTTSGR--WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFN 665 Query: 1225 HECIY 1229 C + Sbjct: 666 TTCYF 670 Score = 59.3 bits (142), Expect = 7e-08 Identities = 106/456 (23%), Positives = 169/456 (37%), Gaps = 87/456 (19%) Query: 1117 LRFISDFSIS-YEGFNITFSEYNLEPCEDPGIPQY-----GSRIGFNFGIGDTLTFSCSS 1170 L I +++ S Y GF EY E C + +PQ+ +G NF +F C+ Sbjct: 175 LETIGNYTCSCYPGFYGPECEYVRE-CGELELPQHVLMNCSHPLG-NFSFNSQCSFHCTD 232 Query: 1171 GYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIY 1229 GY++ G S++ CL G +W+ P+C+A +C P + N C++ Sbjct: 233 GYQVNGPSKLECLASG--IWTNKPPQCLAAQC-------------PPLKIPERGNMTCLH 277 Query: 1230 SIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWL 1289 S + + S+ +F +G L + T G +T + + Sbjct: 278 SAKAFQHQ----SSCSFSCEEGFALVGPEVVQCTAS--GVWTAPAPVCKAVQCQ------ 325 Query: 1290 EFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHG 1349 + +EGT + C P + F Y GS+ + C PGY + G Sbjct: 326 HLEAPSEGTMD-------------CVHP-LTAFAY---------GSSCKFECQPGYRVRG 362 Query: 1350 SSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRI-LSPGY-PFPYDNN--LRCMWMI 1405 +L+C+ + W PLP+C A + G + SP F YD N RC Sbjct: 363 LDMLRCI--DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF 420 Query: 1406 EVDPGNIVSLQFLAFDTEASH--DILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTI 1463 + +IV L T + L+ D P N+ + P G ++ + Sbjct: 421 MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV----NCSHPFGAFRYQSVCSF 476 Query: 1464 QFDTDFYISKSG----FAIQFSSSVATACRD-PGVPMNGTRNG--------DGREPGDTV 1510 + + + A +SV C+ P P+ +NG T Sbjct: 477 TCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTC 536 Query: 1511 VFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546 F CD GY L G ER+ C + W SPP+C A Sbjct: 537 QFICDEGYSLSGPERLDCTRSGR---WTDSPPMCEA 569 Score = 56.6 bits (135), Expect = 4e-07 Identities = 109/514 (21%), Positives = 172/514 (33%), Gaps = 83/514 (16%) Query: 1646 YTGFH---LEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCI 1702 Y GF+ EY + E +MN + ++ S +++C GY + G S L C+ Sbjct: 186 YPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL 245 Query: 1703 MGDDGRPGWNRALPSC-HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVF 1761 W P C A C G + + K + +C +S + F + Sbjct: 246 ASGI----WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCE--EGFALV 299 Query: 1762 GQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGES---LPLSS-GNQITIRFTSVGP 1817 G V T+ V P ++ L G PL++ + +F Sbjct: 300 GPEVVQCTA--SGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPG 357 Query: 1818 ITAKGFHFVY--------QAVPRTSSTQCSSVPEPRFGRRIGNE----FAVGSSVLFDCN 1865 +G + +P + C + P G + F ++ F C Sbjct: 358 YRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCA 417 Query: 1866 PGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNC 1925 G++L G+ +RC+ +L QW P C + P P + +NC Sbjct: 418 EGFMLRGADIVRCD----NLGQWTAPAPVC------------QALQCQDLPVPNEARVNC 461 Query: 1926 -----------VWKITVPEGAG-IQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGT- 1972 V T EG + V+ NW+S+ P L +GT Sbjct: 462 SHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTM 521 Query: 1973 TIPHLLNSTSNNLYLNFQSDISVSAAG-FHLEYTAIG--LDS--------CPEPQTPSSG 2021 T L S+S F D S +G L+ T G DS CPE P G Sbjct: 522 TCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQG 581 Query: 2022 -IKIGD---RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL--------- 2068 + D + VG F CD G+ L+G +++ C RW+ P C Sbjct: 582 SLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS--GRWSATPPTCKGIASLPTPG 639 Query: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTIN 2102 QC + G + PG + + C + N Sbjct: 640 VQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCN 673 Score = 53.5 bits (127), Expect = 4e-06 Identities = 121/600 (20%), Positives = 189/600 (31%), Gaps = 168/600 (28%) Query: 1512 FQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPH 1570 F C GY++ G ++ C+ W PP C+A C G + + + H Sbjct: 228 FHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQH 284 Query: 1571 SRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESS 1630 C SFS E + + GP+ + P + + Sbjct: 285 QSSC-----------------SFSCEEGFALV----GPEVVQCTASGVWTAPAP--VCKA 321 Query: 1631 SNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAG 1690 HL S+G++ C P + GS+ + C G Sbjct: 322 VQCQHLEAPSEGTMD---------------CVHPLTA---------FAYGSSCKFECQPG 357 Query: 1691 YVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCV 1749 Y ++G L CI D G W+ LP+C A C + G++ + + NC Sbjct: 358 YRVRGLDMLRCI--DSGH--WSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCS 413 Query: 1750 YSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQIT 1809 + A + F++ G + Sbjct: 414 FRCA--EGFMLRGADI-------------------------------------------- 427 Query: 1810 IRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGR----RIGNEFAVGSSVLFDCN 1865 +R ++G TA P + QC +P P R F S F CN Sbjct: 428 VRCDNLGQWTAPA--------PVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN 479 Query: 1866 PGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGT--------------- 1909 G +L G+ ++C N WN P C +PC +L+ + GT Sbjct: 480 EGLLLVGASVLQCLATGN----WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKST 535 Query: 1910 ---ILSPGYPEPYDNNLNCV----WKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 1962 I GY L+C W + P I+ + FA E SLD D Sbjct: 536 CQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL-FAPEQG--SLDCSD----- 587 Query: 1963 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG--FHLEYTAIGLDSCPEP----- 2015 G ++ + H S N L +++ + +G T G+ S P P Sbjct: 588 --TRGEFNVGSTCHF--SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643 Query: 2016 --QTPSSGIKI----GDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2069 TP G + F C+ G++L G S ++C P +W P C A Sbjct: 644 ALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRA 701 Score = 52.8 bits (125), Expect = 6e-06 Identities = 91/450 (20%), Positives = 161/450 (35%), Gaps = 80/450 (17%) Query: 634 IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVL 693 + F ++ F C+ GF L+G + + C + W+A P+C + AP + Sbjct: 276 LHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM 335 Query: 694 SPDYP-EGYGNNLNCIWTIISDPGSRIH-----LSFNDFDLESQFDFLAVKDGDSPESPI 747 +P + +C + PG R+ + + + ESP+ Sbjct: 336 DCVHPLTAFAYGSSCKFEC--QPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPV 393 Query: 748 LGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY-NTFGH----------NECPD 796 G+ + L + + F+ RG +I + G +C D Sbjct: 394 HGSM---DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450 Query: 797 PGIPINAR-----RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851 +P AR FG F+ S S C EG + G + C+ W+ + P+C Sbjct: 451 LPVPNEARVNCSHPFGA-FRYQSVCSFTCNEGLLLV-GASVLQCLATGN---WNSVPPEC 505 Query: 852 GA-PCGGHFSAPSGVI--LSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNY-- 906 A PC S +G + + P YK + C+++ + G+S+ ER + Sbjct: 506 QAIPCTPLLSPQNGTMTCVQPLGSSSYKST--CQFI--CDEGYSLSGP-ERLDCTRSGRW 560 Query: 907 ----DVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI---- 958 + E P L +P GS + S + + + +T + +NGFK+ Sbjct: 561 TDSPPMCEAIKCPELFAPEQGSLD--------CSDTRGEFNVGSTCHFSCDNGFKLEGPN 612 Query: 959 HYESVTVNTYSCLDP------GIPVHG----------------RRYGHDFSIGSTVSFSC 996 + E T +S P +P G R + F +T F C Sbjct: 613 NVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGC 672 Query: 997 DSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1026 ++G+ L + L C + W+ P C A+ Sbjct: 673 NAGFTLIGDSTLSCRPSGQWTAVTPACRAV 702 Score = 46.6 bits (109), Expect = 5e-04 Identities = 51/217 (23%), Positives = 80/217 (36%), Gaps = 46/217 (21%) Query: 985 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILS-PGY 1043 +F++GST FSCD+G++L + C + WS PTC + G L+ PG Sbjct: 591 EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQ 650 Query: 1044 PEFYPNSLNCTWTVDVTHGKGVQFNFHTF-HLEDHHDYLLITENGSFTQPLARLTGSDLP 1102 Y H G F F+T + + + LI ++ +P + T + Sbjct: 651 GTMY-----------CRHHPGT-FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA--VT 696 Query: 1103 PTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGD 1162 P A + SE ++ + I S + NF G Sbjct: 697 PACRA------------------------VKCSELHV----NKPIAMNCSNLWGNFSYGS 728 Query: 1163 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1199 +F C G L G+++ C G WS +P C A Sbjct: 729 ICSFHCLEGQLLNGSAQTACQENGH--WSTTVPTCQA 763 Score = 45.8 bits (107), Expect = 8e-04 Identities = 64/261 (24%), Positives = 98/261 (37%), Gaps = 47/261 (18%) Query: 987 SIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEF 1046 S ST F CD GY LS E L C ++ W+ P C+A+ ++ P Sbjct: 531 SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPE----------- 579 Query: 1047 YPNSLNCTWTVDVTHGKGVQFNF-HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTI 1105 SL+C+ T +G +FN T H + + L N R + + PPT Sbjct: 580 -QGSLDCSDT------RG-EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSAT--PPTC 629 Query: 1106 NAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLT 1165 G + +++ G + ++ PG FG T Sbjct: 630 K----GIASLPTPGVQCPALTTPGQGTMYCRHH------PG----------TFGFNTTCY 669 Query: 1166 FSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENN 1224 F C++G+ L G S + C G+ W+A P C A +C N + N N+ Sbjct: 670 FGCNAGFTLIGDSTLSCRPSGQ--WTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYG 727 Query: 1225 HECIYSIQVQAGKGINISART 1245 C S G+ +N SA+T Sbjct: 728 SIC--SFHCLEGQLLNGSAQT 746 Score = 42.4 bits (98), Expect = 0.009 Identities = 53/240 (22%), Positives = 74/240 (30%), Gaps = 66/240 (27%) Query: 446 CPDPGEPENGKRI----GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501 CP PE G F S+ FSC+E + L G + + C W+ P Sbjct: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC----TASGVWTAPAP 317 Query: 502 VCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561 VCK C +L+ PS + CV +TA + + G D Sbjct: 318 VCKAVQC-QHLEAPS------------EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364 Query: 562 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 621 L D G P L T E++ Sbjct: 365 MLRCIDSGHWSAP--------------------------LPTCEAI-------------- 384 Query: 622 ESCGDPGTPLYGIREGD----GFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677 SC +P++G + F F C GF L G + C QW+A P+C Sbjct: 385 -SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443 Score = 42.0 bits (97), Expect = 0.011 Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 2/43 (4%) Query: 2200 FTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2242 F G + FEC PGY + G L C+ S +W+ PLP CEA+ Sbjct: 344 FAYGSSCKFECQPGYRVRGLDMLRCID--SGHWSAPLPTCEAI 384 Score = 42.0 bits (97), Expect = 0.011 Identities = 64/265 (24%), Positives = 95/265 (35%), Gaps = 28/265 (10%) Query: 2175 VYQAYQLQSCPDPRPFR-NGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWN 2233 V QA Q Q P P R N F SF C G L+G S L CL + NWN Sbjct: 442 VCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCL--ATGNWN 499 Query: 2234 HPLPRCEAL-CGGNITAMNGT------IYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFT 2286 P C+A+ C ++ NGT + S Y D + + P + Sbjct: 500 SVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR 559 Query: 2287 VLQTEPIYDFITVWD--GPDQNSPQIGQFSG--NTALESVYSTSNQILIK--FHSDFTTS 2340 + P+ + I + P+Q S G N +S N ++ + + TTS Sbjct: 560 WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS 619 Query: 2341 GFFVLSYHAYQLRVCQPPPPVPNAEILT----------EDDEFEIGDIIRYQCLPGFTLV 2390 G + + + P P V + T F + C GFTL+ Sbjct: 620 GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLI 679 Query: 2391 GNAILTCRLGERLQMDGAPPVCQVL 2415 G++ L+CR Q P C+ + Sbjct: 680 GDSTLSCRPSG--QWTAVTPACRAV 702 Score = 42.0 bits (97), Expect = 0.011 Identities = 23/63 (36%), Positives = 30/63 (47%), Gaps = 8/63 (12%) Query: 446 CPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501 CP+ PE G SD F++GST FSCD + L+G ++ C WS P Sbjct: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVEC----TTSGRWSATPP 627 Query: 502 VCK 504 CK Sbjct: 628 TCK 630 Score = 40.0 bits (92), Expect = 0.043 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 10/88 (11%) Query: 452 PENG-----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVK 506 P+NG + +GS S ST QF CDE Y L G + + C R W+D P+C+ Sbjct: 516 PQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLDCTRSGR----WTDSPPMCEAI 570 Query: 507 TCGSNLQGPSGTFTSPNFPFQYDSNAQC 534 C G+ + +++ + C Sbjct: 571 KCPELFAPEQGSLDCSDTRGEFNVGSTC 598 Score = 36.2 bits (82), Expect = 0.61 Identities = 46/241 (19%), Positives = 75/241 (31%), Gaps = 73/241 (30%) Query: 462 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTS 521 F + F C E ++L+GA + C + + W+ PVC+ C Sbjct: 406 FQYDTNCSFRCAEGFMLRGADIVRCDNLGQ----WTAPAPVCQALQC------------- 448 Query: 522 PNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVL 581 + P ++ C A V E L +G +VLQ L Sbjct: 449 QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG---------------ASVLQCL 493 Query: 582 -TGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREG--- 637 TG N+ + E P TPL + G Sbjct: 494 ATG-------------------------------NWNSVPPECQAIPCTPLLSPQNGTMT 522 Query: 638 -----DGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSNFTAPMGT 691 S + +F C G+ L G + + C + +W+ + P+C C F G+ Sbjct: 523 CVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGS 582 Query: 692 V 692 + Sbjct: 583 L 583 Score = 35.4 bits (80), Expect = 1.0 Identities = 15/38 (39%), Positives = 17/38 (44%) Query: 640 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677 FS + F C G L G CQEN WS +P C Sbjct: 724 FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761 Score = 35.0 bits (79), Expect = 1.4 Identities = 46/223 (20%), Positives = 73/223 (32%), Gaps = 63/223 (28%) Query: 1507 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI---------APCGGNLTGSSG 1557 G T F CD G++L+G + C W +PP C C T G Sbjct: 595 GSTCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQG 651 Query: 1558 FILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGS 1617 + + P + + C Y G ++ LIG Sbjct: 652 TMYCRHHPGTFGFNTTC------------------------------YFGCNAGFTLIG- 680 Query: 1618 FQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDY 1677 DS L R + A R+ K E + MN + L ++ Sbjct: 681 --DSTLSCRPSGQWTAVTPACRA--------------VKCSELHVNKPIAMNCSNLWGNF 724 Query: 1678 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1720 GS +++C G +L G + C ++G W+ +P+C A Sbjct: 725 SYGSICSFHCLEGQLLNGSAQTAC--QENGH--WSTTVPTCQA 763 Score = 34.7 bits (78), Expect = 1.8 Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 18/87 (20%) Query: 152 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGI 211 T F G ++ C GY + G L CI ++ W P+P C A Sbjct: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCI----DSGHWSAPLPTCEA-------------- 383 Query: 212 ISSPSFPNEYHNNADCTWTIVAEPGDT 238 IS + H + DC+ ++ A DT Sbjct: 384 ISCEPLESPVHGSMDCSPSLRAFQYDT 410 Score = 32.7 bits (73), Expect = 6.8 Identities = 22/77 (28%), Positives = 32/77 (41%), Gaps = 9/77 (11%) Query: 1677 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPG--WNRALPSCHA-PCGSRSTGSEGTV 1733 + +T + C+AG+ L G STL+C RP W P+C A C + Sbjct: 662 FGFNTTCYFGCNAGFTLIGDSTLSC------RPSGQWTAVTPACRAVKCSELHVNKPIAM 715 Query: 1734 LSPNYPKNYSVGHNCVY 1750 N N+S G C + Sbjct: 716 NCSNLWGNFSYGSICSF 732 >gi|32261332 seizure related 6 homolog (mouse)-like precursor [Homo sapiens] Length = 1024 Score = 233 bits (595), Expect = 2e-60 Identities = 167/515 (32%), Positives = 247/515 (47%), Gaps = 18/515 (3%) Query: 1199 AECGASATNNEGILLSPNYPLNYENNH-ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1257 A C S +N EG + S +YPL NN EC Y++ V G G+ + ++ +L+ G++L I Sbjct: 279 ALCSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSDGELLSIR 338 Query: 1258 DGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDP 1317 G D T + A + G + S +N + + F + + FQL Y +F LS C P Sbjct: 339 -GVDGPTLTVLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQAFMLS-CNFP 396 Query: 1318 GIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGR 1377 P G ++ +G + C+ GY L G+ +L C+ + W P C A CGG Sbjct: 397 RRPDSG-DVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPICSAPCGGA 455 Query: 1378 FKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1437 + GR+LSP YP + + C+W IE G + L F D + V G Sbjct: 456 VHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLH-DKDRMTVHSGQTN 514 Query: 1438 NDMLLKE-ISGSLIP-EGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495 LL + + +P EG+ S N + I+F +D + S F I+F + C +P + Sbjct: 515 KSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHCYEPYIQN 574 Query: 1496 -NGTRNGDGREPGDTVVFQCDPGYEL-QGEERITCIQVENRYFWQPSPPVCIAPCGGNLT 1553 N T + G V F CDPG+ L QG I CI V + Y W + P+C A CGG L+ Sbjct: 575 GNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPY-WNDTEPLCRAMCGGELS 633 Query: 1554 GSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSP 1613 +G +LSPN+P PY DC W I V + I L I F N D L IYDG + Sbjct: 634 AVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLD-IQFLNLSNSDILTIYDGDEVMPH 692 Query: 1614 LIGSFQDSKLPERIESSSNTMHLAFRSDGS----VSYTGFHLEY-KAKLRESCFDPGNIM 1668 ++G + + P+++ SS+ + + F SD + GF + Y + +SC D I Sbjct: 693 ILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSCSDLPEIQ 752 Query: 1669 NGTRLGMDYKL--GSTVTYYCDAGYVLQGYSTLTC 1701 NG + +L G+ +TY CD GY + G TLTC Sbjct: 753 NGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTC 787 Score = 228 bits (580), Expect = 1e-58 Identities = 191/714 (26%), Positives = 306/714 (42%), Gaps = 87/714 (12%) Query: 1899 CGGILTKRKGTILSPGYPE-PYDNNLNCVWKITVPEGAGIQVQVVSF-ATEHNWDSLDFY 1956 C + +G I S YP P +N L C + +TV G G+++QV S ++ S+ Sbjct: 281 CSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSDGELLSIRGV 340 Query: 1957 DGGDNNAPRLGSYSGTTI---PHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCP 2013 DG P L + T+ ++ S +N + + F++ F L Y A L SC Sbjct: 341 DG-----PTLTVLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQAFML-SCN 394 Query: 2014 EPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2072 P+ P SG + + D + G V F C GY LQG +TC+ W+ PIC A CG Sbjct: 395 FPRRPDSGDVTVMDLHS-GGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPICSAPCG 453 Query: 2073 GAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGS 2131 GA+ + + G +LSP +P N S C WTI P G +HL F D + V SG Sbjct: 454 GAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHD-KDRMTVHSGQ 512 Query: 2132 SETSTVI-GRLSGPQIP-SSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRP 2189 + S ++ L +P L S + + F SD ++ F+I ++A++ C +P Sbjct: 513 TNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHCYEPY- 571 Query: 2190 FRNGFVIGND--FTVGQTISFECFPGYTLI-GNSALTCLHGVSRNWNHPLPRCEALCGGN 2246 +NG +D + +G + F C PG++L G + + C++ WN P C A+CGG Sbjct: 572 IQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPYWNDTEPLCRAMCGGE 631 Query: 2247 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQN 2306 ++A+ G + SP +P+ Y +DC W + V I+++ L D +T++DG + Sbjct: 632 LSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSN-SDILTIYDGDEVM 690 Query: 2307 SPQIGQFSGNTALESVYSTSNQILIKFHSD-----FTTSGFFVLSY-HAYQLRVCQPPPP 2360 +GQ+ GN+ + +YS++ + I+FHSD F F+++Y + C P Sbjct: 691 PHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSCSDLPE 750 Query: 2361 VPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANE 2420 + N T E G I YQC PG+ +VG+ LTC+ L PP C+ + + Sbjct: 751 IQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWD--LSWSSDPPFCEKIMYCTD 808 Query: 2421 LRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNI 2480 PG D L I Sbjct: 809 -----------PGEVDHSTRL--------------------------------------I 819 Query: 2481 QSPV-LISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI----AFYCSTPESP 2535 PV L+ + Y+ G + +S + G R+ + + C P P Sbjct: 820 SDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPHCVSEESLACDNPGLP 879 Query: 2536 PHGYIISQTGGQL-NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 +GY I L + + C GF L+G+ + C + W+ P+P C+ Sbjct: 880 ENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPSH--WNGPLPVCK 931 Score = 216 bits (549), Expect = 4e-55 Identities = 182/671 (27%), Positives = 290/671 (43%), Gaps = 40/671 (5%) Query: 2069 AQCGGAMSDFSGVILSPGFP----GNYPSSLDCTWTINLPIGFGVHLQF--VNFSTETIH 2122 A C + S+ G I S +P N+ L+CT+ + + G+GV LQ VN S + Sbjct: 279 ALCSVSFSNPEGYIDSSDYPLLPLNNF---LECTYNVTVYTGYGVELQVKSVNLSDGEL- 334 Query: 2123 DYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQ 2182 L +R T TV+ + + S T+ S+YF + F + YQA+ L Sbjct: 335 --LSIRGVDGPTLTVLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQAFML- 391 Query: 2183 SCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2242 SC PR +G V D G F C GY L G LTC++ +W+ P C A Sbjct: 392 SCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPICSAP 451 Query: 2243 CGGNI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWD 2301 CGG + A G + SP YP+ Q C W + P G ++++F L D +TV Sbjct: 452 CGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHD-KDRMTVHS 510 Query: 2302 GPDQNSPQIGQF--SGNTALESVYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVCQPP 2358 G S + + + E + S N I I+F SD + F + + A++ C P Sbjct: 511 GQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHCYEP 570 Query: 2359 PPVPNAEILTEDDEFEIGDIIRYQCLPGFTLV-GNAILTCRLGERLQMDGAPPVCQVLCP 2417 + N T D + IG I+ + C PG +L G AI+ C + P+C+ +C Sbjct: 571 Y-IQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPYWNDTEPLCRAMC- 628 Query: 2418 ANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDG 2477 EL + GV+LSP +P+ Y + C W I V + I + ++F D+L +YDG Sbjct: 629 GGELSAVA-GVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNS-DILTIYDG 686 Query: 2478 PNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGN----NKKGFRIRYIAFY----C 2529 + +L G+ S + S+ ++ +Q+ +D +GF + YI C Sbjct: 687 DEVMPHILGQYLGN-SGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSC 745 Query: 2530 STPESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 S +G+ S T + + + CD G+ +VG + C+ +W + P C+ Sbjct: 746 SDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWDL----SWSSDPPFCE 801 Query: 2589 AIS-CGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK 2645 I C P + L +D LVGT + Y CN G+ L L T + GT ++ Sbjct: 802 KIMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSR 861 Query: 2646 TPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTW 2705 P CV + ++ L ++I+ Y + F C G+ +G +I C+ Sbjct: 862 LPHCVSEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPS 921 Query: 2706 SWRNERPYCQI 2716 W P C++ Sbjct: 922 HWNGPLPVCKV 932 Score = 210 bits (535), Expect = 2e-53 Identities = 204/718 (28%), Positives = 307/718 (42%), Gaps = 88/718 (12%) Query: 1546 APCGGNLTGSSGFILSPNFPH-PYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604 A C + + G+I S ++P P + +C + +TV Y + L S ++ + L I Sbjct: 279 ALCSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSDG-ELLSI 337 Query: 1605 --YDGPD----SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLR 1658 DGP +N L+ Q I S +NT+ + FR+ F L Y+A + Sbjct: 338 RGVDGPTLTVLANQTLLVEGQV------IRSPTNTISVYFRTFQDDGLGTFQLHYQAFML 391 Query: 1659 ESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 SC P +G MD G ++C GY LQG LTCI + +P W+ P C Sbjct: 392 -SCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCI--NASKPHWSSQEPIC 448 Query: 1719 HAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEV 1777 APCG + G VLSP+YP+N + C+++I P+ + F D + V Sbjct: 449 SAPCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHDKDRMTV 508 Query: 1778 YDGPTQQSSLLSSLSGSHSGESLP----LSSGNQITIRFTSVGPITAKGFHFVYQAVPRT 1833 + G T +S+LL S ES+P LS GN I I FTS A F+ ++A + Sbjct: 509 HSGQTNKSALLYD---SLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKG 565 Query: 1834 SSTQCSSVPEPRFGRRIGNE--FAVGSSVLFDCNPGYILH-GSIAIRCETVPNSLAQWND 1890 + P + G ++ + +G+ V F C+PG+ L G I C V + WND Sbjct: 566 HCYE----PYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPY--WND 619 Query: 1891 SLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNW 1950 + P C CGG L+ G +LSP +PEPY +C+WKI V E I + + F N Sbjct: 620 TEPLCRAMCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLD-IQFLNLSNS 678 Query: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSD----ISVSAAGFHLEYTA 2006 D L YDG + LG Y G + P L S++ +L + F SD I GF + Y Sbjct: 679 DILTIYDGDEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIE 738 Query: 2007 IGL-DSCPEPQTPSSGIKIGD--RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYP 2063 + DSC + +G K + G +++QCD GY + G +TC W+ Sbjct: 739 VSRNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWD--LSWSSD 796 Query: 2064 IPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF-GVHLQFVNFSTETIH 2122 P C I+ PG S T I+ P+ G +Q+ + Sbjct: 797 PPFC------------EKIMYCTDPGEVDHS---TRLISDPVLLVGTTIQYTCNPGFVLE 841 Query: 2123 DYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQ 2182 + S ET T P S L E SL + + G+ I+Y+ L Sbjct: 842 GSSLLTCYSRETGT-------PIWTSRLPHCVSEESLACDNP-GLPENGYQILYKRLYLP 893 Query: 2183 SCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2240 G++++F C+ G+ L+G + C+ G +WN PLP C+ Sbjct: 894 --------------------GESLTFMCYEGFELMGEVTIRCILGQPSHWNGPLPVCK 931 Score = 203 bits (517), Expect = 2e-51 Identities = 158/526 (30%), Positives = 246/526 (46%), Gaps = 29/526 (5%) Query: 1384 GRILSPGYPF-PYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDI-LRVWDGPPENDML 1441 G I S YP P +N L C + + V G V LQ + + + +R DGP L Sbjct: 290 GYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSDGELLSIRGVDGPT----L 345 Query: 1442 LKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTR 1499 + +L+ EG I S N +++ F T F + + + + + C P P +G Sbjct: 346 TVLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQAFMLS-CNFPRRPDSGDV 404 Query: 1500 NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSS-GF 1558 G F C GYELQG + +TCI + W P+C APCGG + ++ G Sbjct: 405 TVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPH-WSSQEPICSAPCGGAVHNATIGR 463 Query: 1559 ILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLI-GS 1617 +LSP++P S+ C WTI + L F + D + ++ G + S L+ S Sbjct: 464 VLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHDK-DRMTVHSGQTNKSALLYDS 522 Query: 1618 FQDSKLP-ERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMD 1676 Q +P E + S NT+ + F SD + + + F++ ++A + C++P I NG D Sbjct: 523 LQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHCYEP-YIQNGNFTTSD 581 Query: 1677 --YKLGSTVTYYCDAGYVL-QGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTV 1733 Y +G+ V + CD G+ L QG + + CI D P WN P C A CG + G V Sbjct: 582 PTYNIGTIVEFTCDPGHSLEQGPAIIECINVRD--PYWNDTEPLCRAMCGGELSAVAGVV 639 Query: 1734 LSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSG 1793 LSPN+P+ Y G +C++ I V +E +F F S D++ +YDG +L G Sbjct: 640 LSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNSDILTIYDGDEVMPHILGQYLG 699 Query: 1794 SHSGESLPLSSGNQITIRFTS--VGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIG 1851 +SG SS +TI+F S G I KG F+ + + + CS +PE + G + Sbjct: 700 -NSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSCSDLPEIQNGWKTT 758 Query: 1852 N--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1895 + E G+ + + C+PGY + GS + C+ W+ P C Sbjct: 759 SHTELVRGARITYQCDPGYDIVGSDTLTCQWD----LSWSSDPPFC 800 Score = 201 bits (511), Expect = 1e-50 Identities = 203/744 (27%), Positives = 310/744 (41%), Gaps = 87/744 (11%) Query: 823 GFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGY-YKDSLNC 881 G + ET T ++ V+ + P A C FS P G I S +P + L C Sbjct: 252 GSASEESQETTTSTIITTTVITTEQAP---ALCSVSFSNPEGYIDSSDYPLLPLNNFLEC 308 Query: 882 EWVIEAEPGHSIKITFERFQTELNYDVLEVH--DGPNLLSPLLGSYNGTQVPQFLFSSSN 939 + + G+ +++ + + ++L + DGP L +L + Q + S +N Sbjct: 309 TYNVTVYTGYGVELQVKSVNLS-DGELLSIRGVDGPTLT--VLANQTLLVEGQVIRSPTN 365 Query: 940 FIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSG 999 I + F T F++HY++ + SC P P G D G F C G Sbjct: 366 TISVYFRTFQDDGLGTFQLHYQAFML---SCNFPRRPDSGDVTVMDLHSGGVAHFHCHLG 422 Query: 1000 YRLSHEEPLLC---EKNHWWSHPLPTCDALCGGDVRGPS-GTILSPGYPEFYPNSLNCTW 1055 Y L + L C K HW S P C A CGG V + G +LSP YPE S C W Sbjct: 423 YELQGAKMLTCINASKPHWSSQE-PICSAPCGGAVHNATIGRVLSPSYPENTNGSQFCIW 481 Query: 1056 TVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTIN-AGLYGNFR 1114 T++ G+ + +F L HD +T + T A L S ++ GL Sbjct: 482 TIEAPEGQKLHLHFERLLL---HDKDRMTVHSGQTNKSALLYDSLQTESVPFEGLLSEGN 538 Query: 1115 A-QLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFN--FGIGDTLTFSCSSG 1171 ++ F SD + + FNI F + C +P I Q G+ + + IG + F+C G Sbjct: 539 TIRIEFTSDQARAASTFNIRFEAFEKGHCYEPYI-QNGNFTTSDPTYNIGTIVEFTCDPG 597 Query: 1172 YRLE-GTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYS 1230 + LE G + I C+ W+ P C A CG + G++LSPN+P Y +CI+ Sbjct: 598 HSLEQGPAIIECINVRDPYWNDTEPLCRAMCGGELSAVAGVVLSPNWPEPYVEGEDCIWK 657 Query: 1231 IQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLE 1290 I V K I + + +L+ D+L IYDG + H+LG + G S SST + L ++ Sbjct: 658 IHVGEEKRIFLDIQFLNLSNSDILTIYDGDEVMPHILGQYLGNSGPQKLYSSTPD-LTIQ 716 Query: 1291 FNSDTE----GTDEGFQLVYTSFELS-HCEDPGIPQFGYKISDQGHFA-GSTIIYGCNPG 1344 F+SD G +GF + Y + C D Q G+K + G+ I Y C+PG Sbjct: 717 FHSDPAGLIFGKGQGFIMNYIEVSRNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDPG 776 Query: 1345 YTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWM 1404 Y + GS L C + D P I C + + S R++S Sbjct: 777 YDIVGSDTLTCQWDLSWSSDPPFCEKIMYCTDPGEVDHSTRLIS---------------- 820 Query: 1405 IEVDPGNIV--SLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVT 1462 DP +V ++Q+ + + EG S L + Sbjct: 821 ---DPVLLVGTTIQYTC--------------------------NPGFVLEG-SSLLTCYS 850 Query: 1463 IQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGR--EPGDTVVFQCDPGYEL 1520 + T + S+ + S + AC +PG+P NG + R PG+++ F C G+EL Sbjct: 851 RETGTPIWTSRLPHCV---SEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFEL 907 Query: 1521 QGEERITCIQVENRYFWQPSPPVC 1544 GE I CI + + W PVC Sbjct: 908 MGEVTIRCILGQPSH-WNGPLPVC 930 Score = 170 bits (431), Expect = 2e-41 Identities = 183/719 (25%), Positives = 297/719 (41%), Gaps = 98/719 (13%) Query: 681 CLSNFTAPMGTVLSPDYPEGYGNN-LNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKD 739 C +F+ P G + S DYP NN L C + + G + L +L S + L+++ Sbjct: 281 CSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNL-SDGELLSIRG 339 Query: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGI 799 D P +L T + S ++ + + F+ F + Y F C P Sbjct: 340 VDGPTLTVLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQAF-MLSCNFPRR 398 Query: 800 PINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH- 858 P + + G C G+ + QG + +TCI K WS P C APCGG Sbjct: 399 PDSGDVTVMDLHSGGVAHFHCHLGY-ELQGAKMLTCI-NASKPHWSSQEPICSAPCGGAV 456 Query: 859 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 918 +A G +LSP +P S C W IEA G + + FER + D + VH G Sbjct: 457 HNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLH-DKDRMTVHSGQTNK 515 Query: 919 SPLL-GSYNGTQVP-QFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIP 976 S LL S VP + L S N I + FT+D +R+ + F I +E+ C +P I Sbjct: 516 SALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKG--HCYEPYIQ 573 Query: 977 VHGRRYGHD--FSIGSTVSFSCDSGYRLSHEEPLLCE----KNHWWSHPLPTCDALCGGD 1030 +G D ++IG+ V F+CD G+ L + P + E ++ +W+ P C A+CGG+ Sbjct: 574 -NGNFTTSDPTYNIGTIVEFTCDPGHSL-EQGPAIIECINVRDPYWNDTEPLCRAMCGGE 631 Query: 1031 VRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFT 1090 + +G +LSP +PE Y +C W + V K + + +L + D L I + Sbjct: 632 LSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNL-SNSDILTIYD----- 685 Query: 1091 QPLARLTGSDLPPTINAGLYGNFRAQLRFIS--DFSISY------------EGFNITFSE 1136 G ++ P I GN Q + S D +I + +GF + + E Sbjct: 686 -------GDEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIE 738 Query: 1137 YNL-EPCEDPGIPQYGSRIGFNFGI--GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAP 1193 + + C D Q G + + + G +T+ C GY + G+ + C WS+ Sbjct: 739 VSRNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWD--LSWSSD 796 Query: 1194 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDV 1253 P C E I+ + P +++ I + G I + G V Sbjct: 797 PPFC-----------EKIMYCTD-PGEVDHSTRLISDPVLLVGTTIQYTCN-----PGFV 839 Query: 1254 LKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY-TSFELS 1312 L+ G+S+ T +W +L + S E Sbjct: 840 LE----------------GSSLLTCYSRETGTPIWTS------------RLPHCVSEESL 871 Query: 1313 HCEDPGIPQFGYKI-SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1370 C++PG+P+ GY+I + + G ++ + C G+ L G ++C+ G+ W+ PLP C Sbjct: 872 ACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPSHWNGPLPVC 930 Score = 134 bits (336), Expect = 2e-30 Identities = 113/418 (27%), Positives = 178/418 (42%), Gaps = 22/418 (5%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C P P++G D G F C Y LQGAK +TC ++ WS P+C Sbjct: 393 CNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPH--WSSQEPICSA 450 Query: 506 KTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTI 565 G+ G SP++P + + C+W I A K + ++FE L D +T+ Sbjct: 451 PCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQK-LHLHFERLLLH-DKDRMTV 508 Query: 566 GDGGEVGDPRTVLQVLTGSFVP-DLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 G+ + L VP + ++S + + + +D++ + F + ++ EK C Sbjct: 509 -HSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHC 567 Query: 625 GDPGTPLYGIREGDGFSN-RDVLRFECQFGFELI-GEKSIVC--QENNQWSANIPICIFP 680 +P D N ++ F C G L G I C + W+ P+C Sbjct: 568 YEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPYWNDTEPLCRAM 627 Query: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDG 740 C +A G VLSP++PE Y +CIW I RI L +L S D L + DG Sbjct: 628 CGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNL-SNSDILTIYDG 686 Query: 741 DSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHS----MSGRGFNITYNTFGHNE-CP 795 D ILG + G P L S++ L ++F +D + G+GF + Y N+ C Sbjct: 687 DEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSCS 746 Query: 796 DPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851 D N + + +L G+ I+ C+ G+ G++T+TC + WS P C Sbjct: 747 DLPEIQNGWKTTSHTELVRGARITYQCDPGY-DIVGSDTLTC---QWDLSWSSDPPFC 800 Score = 132 bits (332), Expect = 6e-30 Identities = 175/717 (24%), Positives = 286/717 (39%), Gaps = 84/717 (11%) Query: 2241 ALCGGNITAMNGTIYSPGYPD-EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITV 2299 ALC + + G I S YP NF +C + V V G G+ + + + +++ Sbjct: 279 ALCSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSD-GELLSI 337 Query: 2300 WDGPDQNSPQIGQFSGNTAL---ESVYSTSNQILIKFHSDFTTSGF--FVLSYHAYQLRV 2354 G D P + + T L + + S +N I + F + F G F L Y A+ L Sbjct: 338 -RGVD--GPTLTVLANQTLLVEGQVIRSPTNTISVYFRT-FQDDGLGTFQLHYQAFMLS- 392 Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414 C P + ++ D G + + C G+ L G +LTC + P+C Sbjct: 393 CNFPRRPDSGDVTVMD--LHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPICSA 450 Query: 2415 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2474 C + + G +LSP YP++ Q C W+I +G + + E + D + V Sbjct: 451 PC-GGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHDK-DRMTV 508 Query: 2475 YDGPNIQSPVLISLSGDYSSAFN-ITSNGHEVFLQWSADHGNNKKGFRIRYIAF---YCS 2530 + G +S +L S F + S G+ + +++++D F IR+ AF +C Sbjct: 509 HSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHCY 568 Query: 2531 TPESPPHGYIISQTGGQLNSVVRWACDRGFRLV-GKSSAVCRKSSYGYHAWDAPVPACQA 2589 P + S + ++V + CD G L G + C Y W+ P C+A Sbjct: 569 EPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPY--WNDTEPLCRA 626 Query: 2590 ISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK 2645 + CG + G +L+ + Y+ G + + G K + D + N + Sbjct: 627 M-CGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVG---EEKRIFL-----DIQFLNLSN 677 Query: 2646 TPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTK----VVFSCDPG--YHGLGPASIEC 2699 + + + IL G++ +G Y + + F DP G G I Sbjct: 678 SDILTIYDGDEVMPHIL--GQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIM- 734 Query: 2700 LPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVR 2757 N RN+ SC +LP NG K + T G+ + CD G+ +VGS Sbjct: 735 --NYIEVSRND-------SCSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTL 785 Query: 2758 ECLSSGLWSESETRC-LAGHCGIP-ELIVNGQVIGENYGYRDTVV-YQCNPGFRLIGSSV 2814 C WS C +C P E+ + ++I + T + Y CNPGF L GSS+ Sbjct: 786 TCQWDLSWSSDPPFCEKIMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSL 845 Query: 2815 RICQQDHN----WSGQLPSCV---PVSCGHPGSPIYGRTSGNGFNF--------NDVVTF 2859 C W+ +LP CV ++C +PG P NG+ + +TF Sbjct: 846 LTCYSRETGTPIWTSRLPHCVSEESLACDNPGLP------ENGYQILYKRLYLPGESLTF 899 Query: 2860 SCNIGYLMQGPTKAQCQANR--QWSHPPPMCKVVNCSDPGI--PANSKRESKIEHGN 2912 C G+ + G +C + W+ P P+CKV S A + E+ +E GN Sbjct: 900 MCYEGFELMGEVTIRCILGQPSHWNGPLPVCKVNQDSFEHALEVAEAAAETSLEGGN 956 Score = 93.6 bits (231), Expect = 3e-18 Identities = 133/594 (22%), Positives = 216/594 (36%), Gaps = 72/594 (12%) Query: 2833 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMCKV 2890 +SC P P G + + V F C++GY +QG C + WS P+C Sbjct: 391 LSCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPICSA 450 Query: 2891 -----VNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVL-----ICQPN 2940 V+ + G + F T+ + + F +L + + Sbjct: 451 PCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHDKDRMTVHS 510 Query: 2941 GQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH 3000 GQ +K ++ D P L E G+T+ T Q+ N Sbjct: 511 GQTNK---SALLYDSLQTESVPFEGLLSE----GNTIRIEFTSD-----QARAASTFNIR 558 Query: 3001 WSGSQPHCSGDATGTCGDPGTP-GHGSRQESNFRTKSTVRYACDTGYILH-GSEERTCL- 3057 + + G C +P G+ + + + + V + CD G+ L G C+ Sbjct: 559 FEAFEK-------GHCYEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECIN 611 Query: 3058 -ANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGY-----ILSGPS 3111 + W +P C+A+ CG G++ + G S + +EG I G Sbjct: 612 VRDPYWNDTEPLCRAM-CG-------GELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEE 663 Query: 3112 VRQCTANGTWSGTLPNCTIISCGDPGIP-ANGLRYGDDYVVGQNVSYMCQPGYTMELNGS 3170 R + + + I GD +P G G+ G Y P T++ + Sbjct: 664 KRIFLDIQFLNLSNSDILTIYDGDEVMPHILGQYLGNS---GPQKLYSSTPDLTIQFHSD 720 Query: 3171 RIRTCTINGTW--SGVMPTCRAVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYELS 3226 G + R +C P+I NG T G I+Y C PGY++ Sbjct: 721 PAGLIFGKGQGFIMNYIEVSRNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIV 780 Query: 3227 FPAVLTCVGNGTWSGEVPQCLP-KFCGDPGIPAQGKR--EGKSFIYQSEVSFSCNFPFIL 3283 LTC + +WS + P C +C DPG R + + + ++CN F+L Sbjct: 781 GSDTLTCQWDLSWSSDPPFCEKIMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVL 840 Query: 3284 VGSSTRICQADGT----WSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFH 3338 GSS C + T W+ PHC+ +C+NPG+P +G Q + G + F Sbjct: 841 EGSSLLTCYSRETGTPIWTSRLPHCVSEESLACDNPGLPENGYQILYKRLYLPGESLTFM 900 Query: 3339 CKKGHLLQGSTTRTCL--PDLTWSGIQPEC------IPHSCKQPETPAHANVVG 3384 C +G L G T C+ W+G P C H+ + E A ++ G Sbjct: 901 CYEGFELMGEVTIRCILGQPSHWNGPLPVCKVNQDSFEHALEVAEAAAETSLEG 954 Score = 81.3 bits (199), Expect = 2e-14 Identities = 66/262 (25%), Positives = 115/262 (43%), Gaps = 28/262 (10%) Query: 25 CGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYD 83 CGG + G + SP +P C W I A E ++ + F+ L ++ D ++++ Sbjct: 452 CGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHDK-DRMTVHS 510 Query: 84 GHPHPT-----NFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSC 138 G + + + +T F + S + + TSD A +A F + +E + C Sbjct: 511 GQTNKSALLYDSLQTESVPFE---GLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHC 567 Query: 139 GNPGVPPKGVLYGT-RFDVGDKIRYSCVTGYILDGHPQLT-CIANSVNTASWDFPVPICR 196 P + +++G + ++C G+ L+ P + CI +V W+ P+CR Sbjct: 568 YEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECI--NVRDPYWNDTEPLCR 625 Query: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTI-VAEPGDTISLIFTDFQMEEKYDYL 255 A CGG + +G++ SP++P Y DC W I V E IF D Q +L Sbjct: 626 A--MCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEE----KRIFLDIQ------FL 673 Query: 256 EIEGSEPPTIWLSGMNIPPPII 277 + S+ TI+ G + P I+ Sbjct: 674 NLSNSDILTIY-DGDEVMPHIL 694 Score = 76.3 bits (186), Expect = 5e-13 Identities = 114/533 (21%), Positives = 191/533 (35%), Gaps = 87/533 (16%) Query: 2949 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 3005 + M+ C P P + ++ G H+ C L G TC +N HWS + Sbjct: 387 QAFMLSCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTC-INASKPHWSSQE 445 Query: 3006 PHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGR 3065 P CS G + +T+ Y + + + C+ WT Sbjct: 446 PICSAPCGGAVHN-----------------ATIGRVLSPSYPENTNGSQFCI----WTIE 484 Query: 3066 QPECKAVQCGNPGTTANGK--VFRIDGTTFSSSVIYSCM-------EGYILSGPSVR--- 3113 PE + + + K + G T S+++Y + EG + G ++R Sbjct: 485 APEGQKLHLHFERLLLHDKDRMTVHSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEF 544 Query: 3114 ---QCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDD-YVVGQNVSYMCQPGYTMELNG 3169 Q A T++ C +P I D Y +G V + C PG+++E Sbjct: 545 TSDQARAASTFNIRFEAFEKGHCYEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGP 604 Query: 3170 SRIRTCTINGT-WSGVMPTCRAVT---------CPTPPQISNGRLEGTNFDWGFSIS--- 3216 + I + W+ P CRA+ P +EG + W + Sbjct: 605 AIIECINVRDPYWNDTEPLCRAMCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEK 664 Query: 3217 --YICSPGYELSFPAVLTCVGNGTWSGE--VPQCLPKFCGDPGIPAQGKREGKSFIYQSE 3272 ++ LS +LT + G+ +P L ++ G+ G +Y S Sbjct: 665 RIFLDIQFLNLSNSDILTI-----YDGDEVMPHILGQYLGN---------SGPQKLYSST 710 Query: 3273 VSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT-SCENPGVPRHGSQNNTFGFQV 3331 + F G G G + IE ++ SC + ++G + + V Sbjct: 711 PDLTIQFHSDPAGLIF------GKGQGFIMNYIEVSRNDSCSDLPEIQNGWKTTSHTELV 764 Query: 3332 -GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC--IPHSCKQPETPAHANVVGMDLP 3388 G+ + + C G+ + GS T TC DL+WS P C I + E ++ + Sbjct: 765 RGARITYQCDPGYDIVGSDTLTCQWDLSWSSDPPFCEKIMYCTDPGEVDHSTRLISDPVL 824 Query: 3389 SHGYTLIYTCQPGFFLAGGTEHRVCRSDNT----WTGKVPICEAGSKILVKDP 3437 G T+ YTC PGF L G+ C S T WT ++P C + + +P Sbjct: 825 LVGTTIQYTCNPGFVLE-GSSLLTCYSRETGTPIWTSRLPHCVSEESLACDNP 876 Score = 70.1 bits (170), Expect = 4e-11 Identities = 109/455 (23%), Positives = 162/455 (35%), Gaps = 102/455 (22%) Query: 126 FKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNT 185 F+++Y+ S C P P G + G + C GY L G LTCI + + Sbjct: 382 FQLHYQAFMLS-CNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCI--NASK 438 Query: 186 ASWDFPVPICRAEDACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFT 244 W PIC A CGG + ++ G + SPS+P + + C WTI A G + L F Sbjct: 439 PHWSSQEPICSA--PCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFE 496 Query: 245 DFQMEEK----------------YDYLEIEG-------SEPPTIWL----------SGMN 271 + +K YD L+ E SE TI + S N Sbjct: 497 RLLLHDKDRMTVHSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFN 556 Query: 272 IP----------PPIISNKNWLR----------LHFVTDSNHRYRGFSA---------PY 302 I P I N N+ + F D H A PY Sbjct: 557 IRFEAFEKGHCYEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPY 616 Query: 303 -QGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQR----VQ 357 + L GEL G + + P IH + EE+R +Q Sbjct: 617 WNDTEPLCRAMCGGELS----AVAGVVLSPNWPEPYVEGEDCIWKIH-VGEEKRIFLDIQ 671 Query: 358 VTSLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDF-KS 416 +L NS + D + PH P+ + T +L + H + F K Sbjct: 672 FLNLSNSDILTIYDGDEVMPHILGQYLGNSGPQ--KLYSSTPDLTIQFHSDPAGLIFGKG 729 Query: 417 RGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSL--GSTVQFSCDE 474 +GF I+N + + ++ C D E +NG + S L G+ + + CD Sbjct: 730 QGF-------------IMNYIEV-SRNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDP 775 Query: 475 DYVLQGAKSITCQRIAEVFAAWSDHRPVC-KVKTC 508 Y + G+ ++TCQ +WS P C K+ C Sbjct: 776 GYDIVGSDTLTCQ----WDLSWSSDPPFCEKIMYC 806 Score = 70.1 bits (170), Expect = 4e-11 Identities = 44/165 (26%), Positives = 75/165 (45%), Gaps = 16/165 (9%) Query: 2799 VVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS-CGHPGSPIYGR--TSGNGFNFND 2855 + YQC+PG+ ++GS CQ D +WS P C + C PG + S Sbjct: 769 ITYQCDPGYDIVGSDTLTCQWDLSWSSDPPFCEKIMYCTDPGEVDHSTRLISDPVLLVGT 828 Query: 2856 VVTFSCNIGYLMQGPTKAQCQANRQ----WSHPPPMC---KVVNCSDPGIPANSKRESKI 2908 + ++CN G++++G + C + W+ P C + + C +PG+P N + + Sbjct: 829 TIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPHCVSEESLACDNPGLPENGYQ--IL 886 Query: 2909 EHGNFTYGTVVFYDCNPGYFLFGSSVLIC---QPNGQWDKPLPEC 2950 + G + + C G+ L G + C QP+ W+ PLP C Sbjct: 887 YKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPS-HWNGPLPVC 930 Score = 62.4 bits (150), Expect = 8e-09 Identities = 57/200 (28%), Positives = 82/200 (41%), Gaps = 14/200 (7%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGG L + G + SP +P Y G +C W I E RI + Q L D L++YDG Sbjct: 628 CGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNS-DILTIYDG 686 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFA----VSAHGFKVYYEEL-QSSSCG 139 + + G P + S+ +++ SD A GF + Y E+ ++ SC Sbjct: 687 DEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSCS 746 Query: 140 NPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 + G T G +I Y C GY + G LTC + SW P C Sbjct: 747 DLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWD----LSWSSDPPFCEK 802 Query: 198 EDAC--GGTMRGSSGIISSP 215 C G + S+ +IS P Sbjct: 803 IMYCTDPGEVDHSTRLISDP 822 Score = 45.4 bits (106), Expect = 0.001 Identities = 20/60 (33%), Positives = 34/60 (56%), Gaps = 2/60 (3%) Query: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C DPGE ++ R+ SD +G+T+Q++C+ +VL+G+ +TC W+ P C Sbjct: 806 CTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPHC 865 Score = 44.3 bits (103), Expect = 0.002 Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 4/65 (6%) Query: 134 QSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFP 191 +S +C NPG+P G +LY + G+ + + C G+ L G + CI + W+ P Sbjct: 869 ESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILG--QPSHWNGP 926 Query: 192 VPICR 196 +P+C+ Sbjct: 927 LPVCK 931 Score = 40.0 bits (92), Expect = 0.043 Identities = 16/45 (35%), Positives = 26/45 (57%) Query: 156 VGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 200 VG I+Y+C G++L+G LTC + T W +P C +E++ Sbjct: 826 VGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPHCVSEES 870 Score = 37.4 bits (85), Expect = 0.28 Identities = 24/69 (34%), Positives = 34/69 (49%), Gaps = 4/69 (5%) Query: 439 IKTASNLCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAW 496 + S C +PG PENG +I + G ++ F C E + L G +I C I + W Sbjct: 866 VSEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRC--ILGQPSHW 923 Query: 497 SDHRPVCKV 505 + PVCKV Sbjct: 924 NGPLPVCKV 932 Score = 35.4 bits (80), Expect = 1.0 Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 4/62 (6%) Query: 620 EKESCGDPGTPL--YGIREGDGFSNRDVLRFECQFGFELIGEKSIVC--QENNQWSANIP 675 E +C +PG P Y I + + L F C GFEL+GE +I C + + W+ +P Sbjct: 869 ESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPSHWNGPLP 928 Query: 676 IC 677 +C Sbjct: 929 VC 930 Score = 33.5 bits (75), Expect = 4.0 Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 2/41 (4%) Query: 1857 GSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIV 1897 G S+ F C G+ L G + IRC + + WN LP C V Sbjct: 894 GESLTFMCYEGFELMGEVTIRC--ILGQPSHWNGPLPVCKV 932 >gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens] Length = 993 Score = 233 bits (594), Expect = 3e-60 Identities = 157/514 (30%), Positives = 240/514 (46%), Gaps = 16/514 (3%) Query: 1898 PCGGILTKRKGTILSP-GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFY 1956 PC + +G++ SP P D L+C + I+V G G++++V + + Sbjct: 243 PCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEG 302 Query: 1957 DGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG-FHLEYTAIGLDSCPEP 2015 GG + P L + S ++ S ++ L FQS + G FH Y A L SC P Sbjct: 303 LGGPDPLP-LANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLL-SCHFP 360 Query: 2016 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM 2075 + P+ G G F C GY L+G H+TC+ W+ P+C+A CGG + Sbjct: 361 RRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVI 420 Query: 2076 SDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSS-E 2133 + + G I+SPGFPGNY ++L C W + P G +HL F S D L +R+G + E Sbjct: 421 RNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVE 480 Query: 2134 TSTVIGRLSGPQIP-SSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRN 2192 V +P L S+ + +D S G + Y+A+Q C +P Sbjct: 481 APPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYG 540 Query: 2193 GFVIGND-FTVGQTISFECFPGYTLI-GNSALTCLHGVSRNWNHPLPRCEALCGGNITAM 2250 F + VG T+ F C PGYTL G+ + C+ WN P C A+C G IT Sbjct: 541 NFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDS 600 Query: 2251 NGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI 2310 G + SP +P+ Y QDC W V V I ++ VL+ P D +T +DG D + + Sbjct: 601 AGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGP-GDVLTFYDGDDLTARVL 659 Query: 2311 GQFSGNTALESVYSTSNQILIKFHSDFTTS------GFFVLSYHAYQLRVCQPPPPVPNA 2364 GQ+SG + ++++ + I+F SD TS GF + + + C P +PN Sbjct: 660 GQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNG 719 Query: 2365 EILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCR 2398 E G ++ YQC PG+ +VG+++L C+ Sbjct: 720 WKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQ 753 Score = 224 bits (570), Expect = 2e-57 Identities = 180/614 (29%), Positives = 265/614 (43%), Gaps = 37/614 (6%) Query: 1155 GFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLS 1214 G GI T+T S +SG E T+ + P P C + + EG L S Sbjct: 203 GAGIGIQGTITSSTASGDDEETTTTTTIITTTITTVQTPGP-----CSWNFSGPEGSLDS 257 Query: 1215 P-NYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGA 1273 P + + +C + I V G G+ I + L +G+ + + +G L A Sbjct: 258 PTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTV-EGLGGPDPLPLANQSF 316 Query: 1274 SMRGLTLSSTSNQLWLEFNSDTEGTDEG-FQLVYTSFELSHCEDPGIPQFGYKISDQGHF 1332 +RG + S ++Q L F S G F Y ++ LS C P P +G H Sbjct: 317 LLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLS-CHFPRRPAYGDVTVTSLHP 375 Query: 1333 AGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYP 1392 GS + C GY L G+ L C+ + WD P CIA CGG + ++GRI+SPG+P Sbjct: 376 GGSARFH-CATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFP 434 Query: 1393 FPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDG-----PPENDMLLKEISG 1447 Y NNL C W++E G + L F D L + +G PP D E Sbjct: 435 GNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEY-- 492 Query: 1448 SLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREP- 1506 L EG+ S+ ++ TD + +G A+++ + C +P V + P Sbjct: 493 -LPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPV 551 Query: 1507 GDTVVFQCDPGYEL-QGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFP 1565 G TV F CDPGY L QG I C+ + W + P C A C G +T S+G +LSPN+P Sbjct: 552 GTTVEFSCDPGYTLEQGSIIIECVDPHDPQ-WNETEPACRAVCSGEITDSAGVVLSPNWP 610 Query: 1566 HPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPE 1625 PY +DC W + V D I L I P D L YDG D + ++G + + Sbjct: 611 EPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYDGDDLTARVLGQYSGPRSHF 669 Query: 1626 RIESSSNTMHLAFRSDGSVSYTGFHLE-----YKAKLRESCFDPGNIMNGTRLGMDYKL- 1679 ++ +S + + F+SD S G+ ++ ++C + I NG + +L Sbjct: 670 KLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELV 729 Query: 1680 -GSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTG----SEGTVL 1734 G+ VTY C GY + G S L C W+ LPSC G S + Sbjct: 730 HGTVVTYQCYPGYQVVGSSVLMC----QWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLIS 785 Query: 1735 SPNYPKNYSVGHNC 1748 SP +P +V + C Sbjct: 786 SPKFPVGATVQYIC 799 Score = 219 bits (559), Expect = 3e-56 Identities = 182/653 (27%), Positives = 289/653 (44%), Gaps = 51/653 (7%) Query: 2095 LDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQ-IPSS---- 2149 LDC + I++ G+GV ++ N S +R G ET TV G L GP +P + Sbjct: 269 LDCFFYISVYPGYGVEIKVQNIS---------LREG--ETVTVEG-LGGPDPLPLANQSF 316 Query: 2150 ------LFSTTHETSLYFHSDYSQNKQG-FHIVYQAYQLQSCPDPRPFRNGFVIGNDFTV 2202 + S TH+ +L F S G FH YQAY L SC PR G V Sbjct: 317 LLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLL-SCHFPRRPAYGDVTVTSLHP 375 Query: 2203 GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNI-TAMNGTIYSPGYPD 2261 G + F C GY L G LTCL+ W+ P C A CGG I A G I SPG+P Sbjct: 376 GGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPG 435 Query: 2262 EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI--GQFSGNTAL 2319 Y N C WL+ P G ++++F + D + + +G + +P + + Sbjct: 436 NYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPI 495 Query: 2320 ESVYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDI 2378 E + S+ ++ +D + + L Y A+Q C P V + + +G Sbjct: 496 EGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPF-VKYGNFSSSTPTYPVGTT 554 Query: 2379 IRYQCLPGFTLV-GNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDS 2437 + + C PG+TL G+ I+ C Q + P C+ +C + E+ DS GV+LSP +P+ Sbjct: 555 VEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVC-SGEIT-DSAGVVLSPNWPEP 612 Query: 2438 YPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFN 2497 Y Q C W + VE+ I + + + DVL YDG ++ + VL SG S F Sbjct: 613 YGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYDGDDLTARVLGQYSGP-RSHFK 670 Query: 2498 ITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESP--------PHGY-IISQTGGQL 2548 + ++ +V +Q+ +D G + G++ ++ + P + P+G+ SQ Sbjct: 671 LFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVH 730 Query: 2549 NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI-SCGIPKAPTNGG--ILT 2605 +VV + C G+++VG S +C+ W +P+CQ + SC P + I + Sbjct: 731 GTVVTYQCYPGYQVVGSSVLMCQWDL----TWSEDLPSCQRVTSCHDPGDVEHSRRLISS 786 Query: 2606 TDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHG 2665 + VG V Y C+ G+ L + T + G+ ++ P+C++ + Sbjct: 787 PKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPEN 846 Query: 2666 RWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIIS 2718 R + + FSC PGY G ASI+C+P W + P C+ S Sbjct: 847 GARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAAS 899 Score = 206 bits (525), Expect = 3e-52 Identities = 191/713 (26%), Positives = 293/713 (41%), Gaps = 78/713 (10%) Query: 854 PCGGHFSAPSGVILSPGWPGYYKD-SLNCEWVIEAEPGHSIKITFERFQTELNYDV-LEV 911 PC +FS P G + SP D L+C + I PG+ ++I + V +E Sbjct: 243 PCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEG 302 Query: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNG-FKIHYESVTVNTYSC 970 GP+ L L + + Q + S ++ L F + + G F HY++ + SC Sbjct: 303 LGGPDPLP--LANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLL---SC 357 Query: 971 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLC--EKNHWWSHPLPTCDALCG 1028 P P +G G + F C +GY+L L C +W P C A CG Sbjct: 358 HFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACG 417 Query: 1029 GDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENG 1087 G +R + G I+SPG+P Y N+L C W ++ G+ + +F L + D L+I Sbjct: 418 GVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGD 477 Query: 1088 SFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGI 1147 + P + I L + +D S + G + + + C +P + Sbjct: 478 NVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFV 537 Query: 1148 PQYG--SRIGFNFGIGDTLTFSCSSGYRLEGTSEII-CLGGGRRVWSAPLPRCVAECGAS 1204 +YG S + +G T+ FSC GY LE S II C+ W+ P C A C Sbjct: 538 -KYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGE 596 Query: 1205 ATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTT 1264 T++ G++LSPN+P Y +CI+ + V+ K I + R + GDVL YDG D T Sbjct: 597 ITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTA 656 Query: 1265 HLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQ--LVYTSFELSHCED-PGIPQ 1321 +LG ++G +S ++ + ++F SD + G+Q V FE+ + P +P+ Sbjct: 657 RVLGQYSGPRSHFKLFTSMAD-VTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPE 715 Query: 1322 F--GYKISDQGHFAGSTII-YGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAECGG 1376 G+K Q T++ Y C PGY + GSS+L C W LPSC + C Sbjct: 716 IPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD--LTWSEDLPSCQRVTSCHD 773 Query: 1377 RFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1435 E S R++S P +P C D G ++ + HD R P Sbjct: 774 PGDVEHSRRLISSPKFPVGATVQYIC------DQGFVL----MGSSILTCHD--RQAGSP 821 Query: 1436 PENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495 +D K + L P C P Sbjct: 822 KWSDRAPKCLLEQLKP------------------------------------CHGLSAPE 845 Query: 1496 NGTRNGDGR--EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546 NG R+ + + G T+ F C PGY L+G+ I C+ + W PP+C A Sbjct: 846 NGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSH-WSDPPPICRA 897 Score = 190 bits (482), Expect = 3e-47 Identities = 152/556 (27%), Positives = 234/556 (42%), Gaps = 28/556 (5%) Query: 508 CGSNLQGPSGTFTSP-NFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 566 C N GP G+ SP + D C + I+ V ++I + L G G Sbjct: 244 CSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYIS-VYPGYGVEIKVQNISLREGETVTVEG 302 Query: 567 DGGEVGDPRTVLQVLTGSFV--PDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 GG DP L + SF+ +I S + Q L Q+ G + + SC Sbjct: 303 LGGP--DP---LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSC 357 Query: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 682 P P YG RF C G++L G + + C Q W + P+CI C Sbjct: 358 HFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACG 417 Query: 683 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 741 A G ++SP +P Y NNL C W + + G R+HL F L D L +++GD Sbjct: 418 GVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGD 477 Query: 742 SPES-PILGTFTGAEVPSH--LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPG 798 + E+ P+ ++ +P L+S H +E D S + G + Y F C +P Sbjct: 478 NVEAPPVYDSYEVEYLPIEGLLSSGKHFF-VELSTDSSGAAAGMALRYEAFQQGHCYEPF 536 Query: 799 IPI-NARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGG 857 + N + +G+++ C+ G+ QG+ I C+ W+ P C A C G Sbjct: 537 VKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECV-DPHDPQWNETEPACRAVCSG 595 Query: 858 HFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNL 917 + +GV+LSP WP Y +C W + E I + + DVL +DG +L Sbjct: 596 EITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYDGDDL 654 Query: 918 LSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS----NNGFKIHYESVTVNTYSCLDP 973 + +LG Y+G + LF+S + + F +D S GF IH+ V N P Sbjct: 655 TARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELP 714 Query: 974 GIPVHGRRYGH-DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG---- 1028 IP + + G+ V++ C GY++ L+C+ + WS LP+C + Sbjct: 715 EIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDP 774 Query: 1029 GDVRGPSGTILSPGYP 1044 GDV I SP +P Sbjct: 775 GDVEHSRRLISSPKFP 790 Score = 184 bits (467), Expect = 1e-45 Identities = 186/717 (25%), Positives = 300/717 (41%), Gaps = 86/717 (11%) Query: 680 PCLSNFTAPMGTVLSP-DYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVK 738 PC NF+ P G++ SP D L+C + I PG + + + L + + + V+ Sbjct: 243 PCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLR-EGETVTVE 301 Query: 739 DGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRG-FNITYNTFGHNECPDP 797 P+ L + + S +H L FQ+ +G G F+ Y + + C P Sbjct: 302 GLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLS-CHFP 360 Query: 798 GIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGG 857 P + G S C G+ + +G +TC L + W P C A CGG Sbjct: 361 RRPAYGDVTVTSLHPGGSARFHCATGY-QLKGARHLTC-LNATQPFWDSKEPVCIAACGG 418 Query: 858 HF-SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPN 916 +A +G I+SPG+PG Y ++L C W++EA G + + FE+ + D L + +G N Sbjct: 419 VIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDN 478 Query: 917 LLSP-LLGSYNGTQVP-QFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPG 974 + +P + SY +P + L SS ++ +TD+S + G + YE+ C +P Sbjct: 479 VEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQG--HCYEPF 536 Query: 975 IPVHGRRYGH------DFSIGSTVSFSCDSGYRLSHEEPLL-CEKNH--WWSHPLPTCDA 1025 + +YG+ + +G+TV FSCD GY L ++ C H W+ P C A Sbjct: 537 V-----KYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRA 591 Query: 1026 LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITE 1085 +C G++ +G +LSP +PE Y +C W V V K + + + D L + Sbjct: 592 VCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYD 650 Query: 1086 NGSFTQPLARLTGSDLPPTINAGLYGNFR-AQLRFISDFSISY----EGFNITFSEY-NL 1139 T AR+ G P + L+ + ++F SD S +GF I F E Sbjct: 651 GDDLT---ARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRN 707 Query: 1140 EPCED-PGIPQ-YGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1197 + C + P IP + S G +T+ C GY++ G+S ++C WS LP C Sbjct: 708 DTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD--LTWSEDLPSC 765 Query: 1198 VAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGIN-ISARTFHLAQGDVLKI 1256 + S + P + E++ I S + G + I + F L +L Sbjct: 766 QR------------VTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTC 813 Query: 1257 YDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCED 1316 +D + + S + + LE +L C Sbjct: 814 HDRQAGSPKW--------------SDRAPKCLLE-------------------QLKPCHG 840 Query: 1317 PGIPQFGYKISD-QGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1372 P+ G + + Q H AG+TI + C PGY L G + +KC+ G W P P C A Sbjct: 841 LSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRA 897 Score = 183 bits (465), Expect = 2e-45 Identities = 197/723 (27%), Positives = 292/723 (40%), Gaps = 96/723 (13%) Query: 1547 PCGGNLTGSSGFILSP-NFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605 PC N +G G + SP + P DC + I+V Y + + + S+ Sbjct: 243 PCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTV-- 300 Query: 1606 DGPDSNSPLIGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTG-FHLEYKAKLRESCFD 1663 +G PL + Q L + I S ++ L F+S + G FH Y+A L SC Sbjct: 301 EGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLL-SCHF 359 Query: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCG 1723 P G G + ++C GY L+G LTC+ +P W+ P C A CG Sbjct: 360 PRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNAT--QPFWDSKEPVCIAACG 417 Query: 1724 SR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV---FFQTSL---HDVVE 1776 + G ++SP +P NYS C + + P+ GQ + F + SL D + Sbjct: 418 GVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPE-----GQRLHLHFEKVSLAEDDDRLI 472 Query: 1777 VYDGPTQQSSLLSSLSGSHSGESLP----LSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832 + +G ++ + S+ E LP LSSG + ++ A G Y+A + Sbjct: 473 IRNGDNVEAP---PVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQ 529 Query: 1833 TSSTQCSSVPEPRFGRRIGNE--FAVGSSVLFDCNPGYILH-GSIAIRCETVPNSLAQWN 1889 + P ++G + + VG++V F C+PGY L GSI I C V QWN Sbjct: 530 GHCYE----PFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIEC--VDPHDPQWN 583 Query: 1890 DSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN 1949 ++ P C C G +T G +LSP +PEPY +C+W + V E I + + Sbjct: 584 ETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG 643 Query: 1950 WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGL 2009 D L FYDG D A LG YSG L ++ ++ + FQSD S G+ + Sbjct: 644 -DVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFF 702 Query: 2010 -----DSCPE-PQTPSSGIKIGDRYMV-GDVVSFQCDQGYSLQGHSHITCMPGPVRRWNY 2062 D+CPE P+ P+ +V G VV++QC GY + G S + C W+ Sbjct: 703 EVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD--LTWSE 760 Query: 2063 PIPIC--LAQC--GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFST 2118 +P C + C G + +I SP FP C GF + S Sbjct: 761 DLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQ------GF----VLMGSSI 810 Query: 2119 ETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 T HD ++GS + S P+ H S + S KQ H Sbjct: 811 LTCHDR---QAGSPKWSD-----RAPKCLLEQLKPCHGLSAPENGARSPEKQ-LH----- 856 Query: 2179 YQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238 G TI F C PGY L G +++ C+ G +W+ P P Sbjct: 857 ----------------------PAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPI 894 Query: 2239 CEA 2241 C A Sbjct: 895 CRA 897 Score = 137 bits (344), Expect = 3e-31 Identities = 179/771 (23%), Positives = 289/771 (37%), Gaps = 136/771 (17%) Query: 307 TLTHTTSTGELEEHNRTTTGAIAVAST--------------------------PADVTVS 340 T+T +T++G+ EE TTT +T P DV + Sbjct: 211 TITSSTASGDDEETTTTTTIITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTDVGLD 270 Query: 341 SVTAVTIHR-LSEEQRVQVTSLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTK 399 ++++ E +VQ SLR G P P QS R Q+ R+ Sbjct: 271 CFFYISVYPGYGVEIKVQNISLREGETVTVEGLGGPDPLPLANQSFLLRG----QVIRSP 326 Query: 400 ELAVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIG 459 TH+ A+ F+S PG + + + L C P P G Sbjct: 327 -----THQA--ALRFQSLPPPAGPGTFHFHYQAYLLS---------CHFPRRPAYGDVTV 370 Query: 460 SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPS-GT 518 + G + +F C Y L+GA+ +TC + F W PVC + CG ++ + G Sbjct: 371 TSLHPGGSARFHCATGYQLKGARHLTCLNATQPF--WDSKEPVC-IAACGGVIRNATTGR 427 Query: 519 FTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVL 578 SP FP Y +N C W++ A + + ++FE+ L D L I +G V P V Sbjct: 428 IVSPGFPGNYSNNLTCHWLLEAPEGQR-LHLHFEKVSLAEDDDRLIIRNGDNVEAP-PVY 485 Query: 579 QVLTGSFVP-DLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDP---------G 628 ++P + ++S ++ L TD S + G + Y+ ++ C +P Sbjct: 486 DSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSS 545 Query: 629 TPLYGIREGDGFSNRDVLRFECQFGFEL-IGEKSIVCQE--NNQWSANIPICIFPCLSNF 685 TP Y + + F C G+ L G I C + + QW+ P C C Sbjct: 546 TPTYPV--------GTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEI 597 Query: 686 TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPES 745 T G VLSP++PE YG +CIW + + RI L + D L DGD + Sbjct: 598 TDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRI-GPGDVLTFYDGDDLTA 656 Query: 746 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMS----GRGFNITYNTFGHNE-CPD-PGI 799 +LG ++G L ++ + ++FQ+D S +GF I + N+ CP+ P I Sbjct: 657 RVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEI 716 Query: 800 PINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGG 857 P N + +L G+ ++ C G+ + G+ + C + WS +P C Sbjct: 717 P-NGWKSPSQPELVHGTVVTYQCYPGY-QVVGSSVLMC---QWDLTWSEDLPSCQRVTSC 771 Query: 858 HFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNL 917 H PG + S + G +++ ++ + +L HD Sbjct: 772 HD------------PGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQ-- 817 Query: 918 LSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIP 976 GS + P+ L + L +N + ++H T++ Sbjct: 818 ----AGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIH---------- 863 Query: 977 VHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNH--WWSHPLPTCDA 1025 FSC GY L + + C H WS P P C A Sbjct: 864 -----------------FSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRA 897 Score = 102 bits (254), Expect = 7e-21 Identities = 95/361 (26%), Positives = 151/361 (41%), Gaps = 19/361 (5%) Query: 2243 CGGNITAMNGTIYSPGYPDEYPNFQ-DCFWLVRVPPGNGIYI---NFTVLQTEPIYDFIT 2298 C N + G++ SP + DCF+ + V PG G+ I N ++ + E + + Sbjct: 244 CSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVT--VE 301 Query: 2299 VWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHS--DFTTSGFFVLSYHAYQLRVCQ 2356 GPD P Q S + + S ++Q ++F S G F Y AY L Sbjct: 302 GLGGPDP-LPLANQ-SFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHF 359 Query: 2357 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLC 2416 P P +T G R+ C G+ L G LTC + D PVC C Sbjct: 360 PRRPAYGDVTVTS---LHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAAC 416 Query: 2417 PANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2476 +R +TG I+SPG+P +Y N C W + +G + + E ++ D L + + Sbjct: 417 -GGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRN 475 Query: 2477 GPNIQS-PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAF---YCSTP 2532 G N+++ PV S +Y + S+G F++ S D G +RY AF +C P Sbjct: 476 GDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEP 535 Query: 2533 ESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISC 2592 + S + + V ++CD G+ L + S + W+ PAC+A+ Sbjct: 536 FVKYGNFSSSTPTYPVGTTVEFSCDPGYTL-EQGSIIIECVDPHDPQWNETEPACRAVCS 594 Query: 2593 G 2593 G Sbjct: 595 G 595 Score = 99.0 bits (245), Expect = 8e-20 Identities = 66/225 (29%), Positives = 103/225 (45%), Gaps = 9/225 (4%) Query: 22 IYTCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLS 80 I CGG ++ G I SPGFP Y N C W++ A E R+ + F+ +L E+ D L Sbjct: 413 IAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLI 472 Query: 81 LYDGH--PHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSC 138 + +G P + + + + S+ F + L++D + +A G + YE Q C Sbjct: 473 IRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHC 532 Query: 139 GNPGVPPKGVLYGT-RFDVGDKIRYSCVTGYILD-GHPQLTCIANSVNTASWDFPVPICR 196 P V T + VG + +SC GY L+ G + C+ + W+ P CR Sbjct: 533 YEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECV--DPHDPQWNETEPACR 590 Query: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 241 A C G + S+G++ SP++P Y DC W + E I L Sbjct: 591 A--VCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIML 633 Score = 95.9 bits (237), Expect = 7e-19 Identities = 130/552 (23%), Positives = 194/552 (35%), Gaps = 144/552 (26%) Query: 3015 TCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCL--ANGSWTGRQPEC--- 3069 +C P P +G ++ + R+ C TGY L G+ TCL W ++P C Sbjct: 356 SCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAA 415 Query: 3070 -----------KAVQCGNPGTTANG-----------------------------KVFRID 3089 + V G PG +N ++ + Sbjct: 416 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRN 475 Query: 3090 GTTFSSSVIYSC-------MEGYILSGPSV---RQCTANGTWSGTLPNCTIISCGDPGIP 3139 G + +Y +EG + SG ++G +G G P Sbjct: 476 GDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEP 535 Query: 3140 ANGLRYGD------DYVVGQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTCRAV 3191 ++YG+ Y VG V + C PGYT+E GS I C + W+ P CRAV Sbjct: 536 F--VKYGNFSSSTPTYPVGTTVEFSCDPGYTLE-QGSIIIECVDPHDPQWNETEPACRAV 592 Query: 3192 TCPTPPQISNGRLEGTNFD----------WGFSIS-----------YICSPGYELSF--P 3228 C S G + N+ WG + PG L+F Sbjct: 593 -CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDG 651 Query: 3229 AVLTCVGNGTWSG---------EVPQCLPKFCGDPGIPAQGKREG--------------- 3264 LT G +SG + +F DPG G ++G Sbjct: 652 DDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCP 711 Query: 3265 --------------KSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT 3310 ++ + V++ C + +VGSS +CQ D TWS P C T Sbjct: 712 ELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC--QRVT 769 Query: 3311 SCENPGVPRHGSQ-NNTFGFQVGSVVQFHCKKGHLLQGSTTRTC----LPDLTWSGIQPE 3365 SC +PG H + ++ F VG+ VQ+ C +G +L GS+ TC WS P+ Sbjct: 770 SCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPK 829 Query: 3366 CI------PHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR-VCRSDNT 3418 C+ H PE A + L G T+ ++C PG+ L G + V + Sbjct: 830 CLLEQLKPCHGLSAPENGARS--PEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSH 887 Query: 3419 WTGKVPICEAGS 3430 W+ PIC A S Sbjct: 888 WSDPPPICRAAS 899 Score = 95.1 bits (235), Expect = 1e-18 Identities = 138/570 (24%), Positives = 204/570 (35%), Gaps = 115/570 (20%) Query: 2590 ISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRC 2649 +SC P+ P G + T G + C GY+L T + + W + K P C Sbjct: 355 LSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDS--KEPVC 412 Query: 2650 VVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRN 2709 + C + I RIV+ PG+ G ++ C W Sbjct: 413 IAA-CGGV---IRNATTGRIVS---------------PGFPGNYSNNLTC------HWLL 447 Query: 2710 ERP-------YCQIISCGELPTP---PNGNKIGTQTSYGSTAIFTCDL-GFMLVGSAVRE 2758 E P + + +S E NG+ + Y S + + G + G Sbjct: 448 EAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFV 507 Query: 2759 CLS---SGLWSESETRCLA---GHCGIPELIV-NGQVIGENYGYRDTVVYQCNPGFRLIG 2811 LS SG + R A GHC P + N Y TV + C+PG+ L Sbjct: 508 ELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQ 567 Query: 2812 SSVRI-CQQDHN--WSGQLPSCVPV-------SCGHPGSPIYGRTSGNG------FNFND 2855 S+ I C H+ W+ P+C V S G SP + G G + + Sbjct: 568 GSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEE 627 Query: 2856 VVTFSCNIGYLMQGPTKA---------QCQANRQWSHPPPMCKVVNC---------SDPG 2897 +I L GP + Q+S P K+ SDPG Sbjct: 628 DKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPG 687 Query: 2898 ----------------IPANSKRESKIEHGN---------FTYGTVVFYDCNPGYFLFGS 2932 +P N E N +GTVV Y C PGY + GS Sbjct: 688 TSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGS 747 Query: 2933 SVLICQPNGQWDKPLPECIMI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLG 2989 SVL+CQ + W + LP C + C PG ++ ++S K+ G+TV Y C L+G Sbjct: 748 SVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMG 807 Query: 2990 QSSRTCQ----LNGHWSGSQPHCSGDATGTCGDPGTPGHGSR--QESNFRTKSTVRYACD 3043 S TC + WS P C + C P +G+R ++ +T+ ++C Sbjct: 808 SSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCA 867 Query: 3044 TGYILHGSEERTCLAN--GSWTGRQPECKA 3071 GY+L G C+ W+ P C+A Sbjct: 868 PGYVLKGQASIKCVPGHPSHWSDPPPICRA 897 Score = 86.7 bits (213), Expect = 4e-16 Identities = 153/607 (25%), Positives = 217/607 (35%), Gaps = 141/607 (23%) Query: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773 ++SC P G+ T G +A F C G+ L G+ CL++ W E C+ Sbjct: 354 LLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCI 413 Query: 2774 AGHCGIPELIVNGQVIGENY--GYRDTV----VYQCNPGFR--LIGSSVRICQQDHNW-- 2823 A G+ G+++ + Y + + + + G R L V + + D Sbjct: 414 AACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLII 473 Query: 2824 -SGQLPSCVPVSCGHPGS--PIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ 2880 +G PV + PI G S F ++ T S M +A Q Sbjct: 474 RNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQG--- 530 Query: 2881 WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF-----TY--GTVVFYDCNPGYFLFGSS 2933 +C +P +++GNF TY GT V + C+PGY L S Sbjct: 531 -----------HCYEP----------FVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGS 569 Query: 2934 VLI--CQPNG-QWDKPLPECIMIDCGHPGVPPNAVLS---GEKYTFGST----VHYSCTG 2983 ++I P+ QW++ P C + G VLS E Y G VH Sbjct: 570 IIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVE-ED 628 Query: 2984 KRSLL----------------GQSSRTCQLNGHWSGSQPH-----CSGDAT-GTCGDPGT 3021 KR +L T ++ G +SG + H D T DPGT Sbjct: 629 KRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGT 688 Query: 3022 PGHGSRQESNFRTKSTVRYACDTGYILHGSE---ERTC-----LANGSWTGRQPECKAVQ 3073 G +Q G+++H E TC + NG + QPE Sbjct: 689 SVLGYQQ----------------GFVIHFFEVPRNDTCPELPEIPNGWKSPSQPEL---- 728 Query: 3074 CGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC-TIIS 3132 + GT V Y C GY + G SV C + TWS LP+C + S Sbjct: 729 --------------VHGTV----VTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTS 770 Query: 3133 CGDPGIPANGLRY--GDDYVVGQNVSYMCQPGYTMELNGSRIRTC----TINGTWSGVMP 3186 C DPG + R + VG V Y+C G+ L GS I TC + WS P Sbjct: 771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFV--LMGSSILTCHDRQAGSPKWSDRAP 828 Query: 3187 TC---RAVTCPTPPQISNGRL--EGTNFDWGFSISYICSPGYELSFPAVLTCVGN--GTW 3239 C + C NG E G +I + C+PGY L A + CV W Sbjct: 829 KCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHW 888 Query: 3240 SGEVPQC 3246 S P C Sbjct: 889 SDPPPIC 895 Score = 79.3 bits (194), Expect = 6e-14 Identities = 79/291 (27%), Positives = 114/291 (39%), Gaps = 21/291 (7%) Query: 25 CGGTLKGLNGTIESPGFPYGYPN--GANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82 C G G+++SP P G +C + I ++I Q+ +L E Sbjct: 244 CSWNFSGPEGSLDSPT-DLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEG 302 Query: 83 DGHPHP---TNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 G P P N L G + P +LR S + G ++ + SC Sbjct: 303 LGGPDPLPLANQSFLLRGQVIRSPTHQA----ALRFQSLPPPAGPGTFHFHYQAYLLSCH 358 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 P P G + T G R+ C TGY L G LTC+ + WD P+C A Sbjct: 359 FPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL--NATQPFWDSKEPVCIA-- 414 Query: 200 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIE 258 ACGG +R ++ G I SP FP Y NN C W + A G + L F + E D L I Sbjct: 415 ACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIR 474 Query: 259 GSE----PPTIWLSGMNIPP--PIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 + PP + P ++S+ + TDS+ G + Y+ Sbjct: 475 NGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYE 525 Score = 74.7 bits (182), Expect = 2e-12 Identities = 55/191 (28%), Positives = 82/191 (42%), Gaps = 16/191 (8%) Query: 2718 SCGELPTPPNGNKIGTQTS--YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCL-A 2774 +C ELP PNG K +Q +G+ + C G+ +VGS+V C WSE C Sbjct: 709 TCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRV 768 Query: 2775 GHCGIPELIVNGQ--VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH----NWSGQLP 2828 C P + + + + + TV Y C+ GF L+GSS+ C WS + P Sbjct: 769 TSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAP 828 Query: 2829 SCVPVS---CGHPGSPIYGRTSGNG--FNFNDVVTFSCNIGYLMQGPTKAQCQANR--QW 2881 C+ C +P G S + FSC GY+++G +C W Sbjct: 829 KCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHW 888 Query: 2882 SHPPPMCKVVN 2892 S PPP+C+ + Sbjct: 889 SDPPPICRAAS 899 Score = 58.5 bits (140), Expect = 1e-07 Identities = 48/203 (23%), Positives = 86/203 (42%), Gaps = 14/203 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 C G + G + SP +P Y G +C W + EE RI + + + D L+ YDG Sbjct: 593 CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYDG 651 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-----YYEELQSSSCG 139 + +G + ++ + +++ SD S G++ ++E ++ +C Sbjct: 652 DDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCP 711 Query: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 P G ++ ++ G + Y C GY + G L C + +W +P C+ Sbjct: 712 ELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD----LTWSEDLPSCQR 767 Query: 198 EDAC--GGTMRGSSGIISSPSFP 218 +C G + S +ISSP FP Sbjct: 768 VTSCHDPGDVEHSRRLISSPKFP 790 Score = 39.3 bits (90), Expect = 0.073 Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 2/60 (3%) Query: 157 GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPS 216 G I +SC GY+L G + C+ + + W P PICRA G S + +P+ Sbjct: 859 GATIHFSCAPGYVLKGQASIKCVPG--HPSHWSDPPPICRAASLDGFYNSRSLDVAKAPA 916 Score = 37.7 bits (86), Expect = 0.21 Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 8/105 (7%) Query: 136 SSCGNPG--VPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVP 193 +SC +PG + ++ +F VG ++Y C G++L G LTC + W P Sbjct: 769 TSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAP 828 Query: 194 ICRAED--ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPG 236 C E C G +G S P + + A T PG Sbjct: 829 KCLLEQLKPCHGLSAPENGARS----PEKQLHPAGATIHFSCAPG 869 >gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens] Length = 994 Score = 233 bits (594), Expect = 3e-60 Identities = 157/514 (30%), Positives = 240/514 (46%), Gaps = 16/514 (3%) Query: 1898 PCGGILTKRKGTILSP-GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFY 1956 PC + +G++ SP P D L+C + I+V G G++++V + + Sbjct: 243 PCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEG 302 Query: 1957 DGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG-FHLEYTAIGLDSCPEP 2015 GG + P L + S ++ S ++ L FQS + G FH Y A L SC P Sbjct: 303 LGGPDPLP-LANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLL-SCHFP 360 Query: 2016 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM 2075 + P+ G G F C GY L+G H+TC+ W+ P+C+A CGG + Sbjct: 361 RRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVI 420 Query: 2076 SDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSS-E 2133 + + G I+SPGFPGNY ++L C W + P G +HL F S D L +R+G + E Sbjct: 421 RNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVE 480 Query: 2134 TSTVIGRLSGPQIP-SSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRN 2192 V +P L S+ + +D S G + Y+A+Q C +P Sbjct: 481 APPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYG 540 Query: 2193 GFVIGND-FTVGQTISFECFPGYTLI-GNSALTCLHGVSRNWNHPLPRCEALCGGNITAM 2250 F + VG T+ F C PGYTL G+ + C+ WN P C A+C G IT Sbjct: 541 NFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDS 600 Query: 2251 NGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI 2310 G + SP +P+ Y QDC W V V I ++ VL+ P D +T +DG D + + Sbjct: 601 AGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGP-GDVLTFYDGDDLTARVL 659 Query: 2311 GQFSGNTALESVYSTSNQILIKFHSDFTTS------GFFVLSYHAYQLRVCQPPPPVPNA 2364 GQ+SG + ++++ + I+F SD TS GF + + + C P +PN Sbjct: 660 GQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNG 719 Query: 2365 EILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCR 2398 E G ++ YQC PG+ +VG+++L C+ Sbjct: 720 WKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQ 753 Score = 224 bits (570), Expect = 2e-57 Identities = 180/614 (29%), Positives = 265/614 (43%), Gaps = 37/614 (6%) Query: 1155 GFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLS 1214 G GI T+T S +SG E T+ + P P C + + EG L S Sbjct: 203 GAGIGIQGTITSSTASGDDEETTTTTTIITTTITTVQTPGP-----CSWNFSGPEGSLDS 257 Query: 1215 P-NYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGA 1273 P + + +C + I V G G+ I + L +G+ + + +G L A Sbjct: 258 PTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTV-EGLGGPDPLPLANQSF 316 Query: 1274 SMRGLTLSSTSNQLWLEFNSDTEGTDEG-FQLVYTSFELSHCEDPGIPQFGYKISDQGHF 1332 +RG + S ++Q L F S G F Y ++ LS C P P +G H Sbjct: 317 LLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLS-CHFPRRPAYGDVTVTSLHP 375 Query: 1333 AGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYP 1392 GS + C GY L G+ L C+ + WD P CIA CGG + ++GRI+SPG+P Sbjct: 376 GGSARFH-CATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFP 434 Query: 1393 FPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDG-----PPENDMLLKEISG 1447 Y NNL C W++E G + L F D L + +G PP D E Sbjct: 435 GNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEY-- 492 Query: 1448 SLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREP- 1506 L EG+ S+ ++ TD + +G A+++ + C +P V + P Sbjct: 493 -LPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPV 551 Query: 1507 GDTVVFQCDPGYEL-QGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFP 1565 G TV F CDPGY L QG I C+ + W + P C A C G +T S+G +LSPN+P Sbjct: 552 GTTVEFSCDPGYTLEQGSIIIECVDPHDPQ-WNETEPACRAVCSGEITDSAGVVLSPNWP 610 Query: 1566 HPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPE 1625 PY +DC W + V D I L I P D L YDG D + ++G + + Sbjct: 611 EPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYDGDDLTARVLGQYSGPRSHF 669 Query: 1626 RIESSSNTMHLAFRSDGSVSYTGFHLE-----YKAKLRESCFDPGNIMNGTRLGMDYKL- 1679 ++ +S + + F+SD S G+ ++ ++C + I NG + +L Sbjct: 670 KLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELV 729 Query: 1680 -GSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTG----SEGTVL 1734 G+ VTY C GY + G S L C W+ LPSC G S + Sbjct: 730 HGTVVTYQCYPGYQVVGSSVLMC----QWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLIS 785 Query: 1735 SPNYPKNYSVGHNC 1748 SP +P +V + C Sbjct: 786 SPKFPVGATVQYIC 799 Score = 219 bits (559), Expect = 3e-56 Identities = 182/653 (27%), Positives = 289/653 (44%), Gaps = 51/653 (7%) Query: 2095 LDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQ-IPSS---- 2149 LDC + I++ G+GV ++ N S +R G ET TV G L GP +P + Sbjct: 269 LDCFFYISVYPGYGVEIKVQNIS---------LREG--ETVTVEG-LGGPDPLPLANQSF 316 Query: 2150 ------LFSTTHETSLYFHSDYSQNKQG-FHIVYQAYQLQSCPDPRPFRNGFVIGNDFTV 2202 + S TH+ +L F S G FH YQAY L SC PR G V Sbjct: 317 LLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLL-SCHFPRRPAYGDVTVTSLHP 375 Query: 2203 GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNI-TAMNGTIYSPGYPD 2261 G + F C GY L G LTCL+ W+ P C A CGG I A G I SPG+P Sbjct: 376 GGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPG 435 Query: 2262 EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI--GQFSGNTAL 2319 Y N C WL+ P G ++++F + D + + +G + +P + + Sbjct: 436 NYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPI 495 Query: 2320 ESVYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDI 2378 E + S+ ++ +D + + L Y A+Q C P V + + +G Sbjct: 496 EGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPF-VKYGNFSSSTPTYPVGTT 554 Query: 2379 IRYQCLPGFTLV-GNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDS 2437 + + C PG+TL G+ I+ C Q + P C+ +C + E+ DS GV+LSP +P+ Sbjct: 555 VEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVC-SGEIT-DSAGVVLSPNWPEP 612 Query: 2438 YPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFN 2497 Y Q C W + VE+ I + + + DVL YDG ++ + VL SG S F Sbjct: 613 YGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYDGDDLTARVLGQYSGP-RSHFK 670 Query: 2498 ITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESP--------PHGY-IISQTGGQL 2548 + ++ +V +Q+ +D G + G++ ++ + P + P+G+ SQ Sbjct: 671 LFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVH 730 Query: 2549 NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI-SCGIPKAPTNGG--ILT 2605 +VV + C G+++VG S +C+ W +P+CQ + SC P + I + Sbjct: 731 GTVVTYQCYPGYQVVGSSVLMCQWDL----TWSEDLPSCQRVTSCHDPGDVEHSRRLISS 786 Query: 2606 TDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHG 2665 + VG V Y C+ G+ L + T + G+ ++ P+C++ + Sbjct: 787 PKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPEN 846 Query: 2666 RWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIIS 2718 R + + FSC PGY G ASI+C+P W + P C+ S Sbjct: 847 GARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAAS 899 Score = 206 bits (525), Expect = 3e-52 Identities = 191/713 (26%), Positives = 293/713 (41%), Gaps = 78/713 (10%) Query: 854 PCGGHFSAPSGVILSPGWPGYYKD-SLNCEWVIEAEPGHSIKITFERFQTELNYDV-LEV 911 PC +FS P G + SP D L+C + I PG+ ++I + V +E Sbjct: 243 PCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEG 302 Query: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNG-FKIHYESVTVNTYSC 970 GP+ L L + + Q + S ++ L F + + G F HY++ + SC Sbjct: 303 LGGPDPLP--LANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLL---SC 357 Query: 971 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLC--EKNHWWSHPLPTCDALCG 1028 P P +G G + F C +GY+L L C +W P C A CG Sbjct: 358 HFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACG 417 Query: 1029 GDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENG 1087 G +R + G I+SPG+P Y N+L C W ++ G+ + +F L + D L+I Sbjct: 418 GVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGD 477 Query: 1088 SFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGI 1147 + P + I L + +D S + G + + + C +P + Sbjct: 478 NVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFV 537 Query: 1148 PQYG--SRIGFNFGIGDTLTFSCSSGYRLEGTSEII-CLGGGRRVWSAPLPRCVAECGAS 1204 +YG S + +G T+ FSC GY LE S II C+ W+ P C A C Sbjct: 538 -KYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGE 596 Query: 1205 ATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTT 1264 T++ G++LSPN+P Y +CI+ + V+ K I + R + GDVL YDG D T Sbjct: 597 ITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTA 656 Query: 1265 HLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQ--LVYTSFELSHCED-PGIPQ 1321 +LG ++G +S ++ + ++F SD + G+Q V FE+ + P +P+ Sbjct: 657 RVLGQYSGPRSHFKLFTSMAD-VTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPE 715 Query: 1322 F--GYKISDQGHFAGSTII-YGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAECGG 1376 G+K Q T++ Y C PGY + GSS+L C W LPSC + C Sbjct: 716 IPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD--LTWSEDLPSCQRVTSCHD 773 Query: 1377 RFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1435 E S R++S P +P C D G ++ + HD R P Sbjct: 774 PGDVEHSRRLISSPKFPVGATVQYIC------DQGFVL----MGSSILTCHD--RQAGSP 821 Query: 1436 PENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495 +D K + L P C P Sbjct: 822 KWSDRAPKCLLEQLKP------------------------------------CHGLSAPE 845 Query: 1496 NGTRNGDGR--EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546 NG R+ + + G T+ F C PGY L+G+ I C+ + W PP+C A Sbjct: 846 NGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSH-WSDPPPICRA 897 Score = 190 bits (482), Expect = 3e-47 Identities = 152/556 (27%), Positives = 234/556 (42%), Gaps = 28/556 (5%) Query: 508 CGSNLQGPSGTFTSP-NFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 566 C N GP G+ SP + D C + I+ V ++I + L G G Sbjct: 244 CSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYIS-VYPGYGVEIKVQNISLREGETVTVEG 302 Query: 567 DGGEVGDPRTVLQVLTGSFV--PDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 GG DP L + SF+ +I S + Q L Q+ G + + SC Sbjct: 303 LGGP--DP---LPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSC 357 Query: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 682 P P YG RF C G++L G + + C Q W + P+CI C Sbjct: 358 HFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACG 417 Query: 683 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 741 A G ++SP +P Y NNL C W + + G R+HL F L D L +++GD Sbjct: 418 GVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGD 477 Query: 742 SPES-PILGTFTGAEVPSH--LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPG 798 + E+ P+ ++ +P L+S H +E D S + G + Y F C +P Sbjct: 478 NVEAPPVYDSYEVEYLPIEGLLSSGKHFF-VELSTDSSGAAAGMALRYEAFQQGHCYEPF 536 Query: 799 IPI-NARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGG 857 + N + +G+++ C+ G+ QG+ I C+ W+ P C A C G Sbjct: 537 VKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECV-DPHDPQWNETEPACRAVCSG 595 Query: 858 HFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNL 917 + +GV+LSP WP Y +C W + E I + + DVL +DG +L Sbjct: 596 EITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYDGDDL 654 Query: 918 LSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS----NNGFKIHYESVTVNTYSCLDP 973 + +LG Y+G + LF+S + + F +D S GF IH+ V N P Sbjct: 655 TARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELP 714 Query: 974 GIPVHGRRYGH-DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG---- 1028 IP + + G+ V++ C GY++ L+C+ + WS LP+C + Sbjct: 715 EIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDP 774 Query: 1029 GDVRGPSGTILSPGYP 1044 GDV I SP +P Sbjct: 775 GDVEHSRRLISSPKFP 790 Score = 184 bits (467), Expect = 1e-45 Identities = 186/717 (25%), Positives = 300/717 (41%), Gaps = 86/717 (11%) Query: 680 PCLSNFTAPMGTVLSP-DYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVK 738 PC NF+ P G++ SP D L+C + I PG + + + L + + + V+ Sbjct: 243 PCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLR-EGETVTVE 301 Query: 739 DGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRG-FNITYNTFGHNECPDP 797 P+ L + + S +H L FQ+ +G G F+ Y + + C P Sbjct: 302 GLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLS-CHFP 360 Query: 798 GIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGG 857 P + G S C G+ + +G +TC L + W P C A CGG Sbjct: 361 RRPAYGDVTVTSLHPGGSARFHCATGY-QLKGARHLTC-LNATQPFWDSKEPVCIAACGG 418 Query: 858 HF-SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPN 916 +A +G I+SPG+PG Y ++L C W++EA G + + FE+ + D L + +G N Sbjct: 419 VIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDN 478 Query: 917 LLSP-LLGSYNGTQVP-QFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPG 974 + +P + SY +P + L SS ++ +TD+S + G + YE+ C +P Sbjct: 479 VEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQG--HCYEPF 536 Query: 975 IPVHGRRYGH------DFSIGSTVSFSCDSGYRLSHEEPLL-CEKNH--WWSHPLPTCDA 1025 + +YG+ + +G+TV FSCD GY L ++ C H W+ P C A Sbjct: 537 V-----KYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRA 591 Query: 1026 LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITE 1085 +C G++ +G +LSP +PE Y +C W V V K + + + D L + Sbjct: 592 VCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYD 650 Query: 1086 NGSFTQPLARLTGSDLPPTINAGLYGNFR-AQLRFISDFSISY----EGFNITFSEY-NL 1139 T AR+ G P + L+ + ++F SD S +GF I F E Sbjct: 651 GDDLT---ARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRN 707 Query: 1140 EPCED-PGIPQ-YGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1197 + C + P IP + S G +T+ C GY++ G+S ++C WS LP C Sbjct: 708 DTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD--LTWSEDLPSC 765 Query: 1198 VAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGIN-ISARTFHLAQGDVLKI 1256 + S + P + E++ I S + G + I + F L +L Sbjct: 766 QR------------VTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTC 813 Query: 1257 YDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCED 1316 +D + + S + + LE +L C Sbjct: 814 HDRQAGSPKW--------------SDRAPKCLLE-------------------QLKPCHG 840 Query: 1317 PGIPQFGYKISD-QGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1372 P+ G + + Q H AG+TI + C PGY L G + +KC+ G W P P C A Sbjct: 841 LSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRA 897 Score = 183 bits (465), Expect = 2e-45 Identities = 197/723 (27%), Positives = 292/723 (40%), Gaps = 96/723 (13%) Query: 1547 PCGGNLTGSSGFILSP-NFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605 PC N +G G + SP + P DC + I+V Y + + + S+ Sbjct: 243 PCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTV-- 300 Query: 1606 DGPDSNSPLIGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTG-FHLEYKAKLRESCFD 1663 +G PL + Q L + I S ++ L F+S + G FH Y+A L SC Sbjct: 301 EGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLL-SCHF 359 Query: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCG 1723 P G G + ++C GY L+G LTC+ +P W+ P C A CG Sbjct: 360 PRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNAT--QPFWDSKEPVCIAACG 417 Query: 1724 SR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV---FFQTSL---HDVVE 1776 + G ++SP +P NYS C + + P+ GQ + F + SL D + Sbjct: 418 GVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPE-----GQRLHLHFEKVSLAEDDDRLI 472 Query: 1777 VYDGPTQQSSLLSSLSGSHSGESLP----LSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832 + +G ++ + S+ E LP LSSG + ++ A G Y+A + Sbjct: 473 IRNGDNVEAP---PVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQ 529 Query: 1833 TSSTQCSSVPEPRFGRRIGNE--FAVGSSVLFDCNPGYILH-GSIAIRCETVPNSLAQWN 1889 + P ++G + + VG++V F C+PGY L GSI I C V QWN Sbjct: 530 GHCYE----PFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIEC--VDPHDPQWN 583 Query: 1890 DSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN 1949 ++ P C C G +T G +LSP +PEPY +C+W + V E I + + Sbjct: 584 ETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG 643 Query: 1950 WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGL 2009 D L FYDG D A LG YSG L ++ ++ + FQSD S G+ + Sbjct: 644 -DVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFF 702 Query: 2010 -----DSCPE-PQTPSSGIKIGDRYMV-GDVVSFQCDQGYSLQGHSHITCMPGPVRRWNY 2062 D+CPE P+ P+ +V G VV++QC GY + G S + C W+ Sbjct: 703 EVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD--LTWSE 760 Query: 2063 PIPIC--LAQC--GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFST 2118 +P C + C G + +I SP FP C GF + S Sbjct: 761 DLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQ------GF----VLMGSSI 810 Query: 2119 ETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 T HD ++GS + S P+ H S + S KQ H Sbjct: 811 LTCHDR---QAGSPKWSD-----RAPKCLLEQLKPCHGLSAPENGARSPEKQ-LH----- 856 Query: 2179 YQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238 G TI F C PGY L G +++ C+ G +W+ P P Sbjct: 857 ----------------------PAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPI 894 Query: 2239 CEA 2241 C A Sbjct: 895 CRA 897 Score = 137 bits (344), Expect = 3e-31 Identities = 179/771 (23%), Positives = 289/771 (37%), Gaps = 136/771 (17%) Query: 307 TLTHTTSTGELEEHNRTTTGAIAVAST--------------------------PADVTVS 340 T+T +T++G+ EE TTT +T P DV + Sbjct: 211 TITSSTASGDDEETTTTTTIITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTDVGLD 270 Query: 341 SVTAVTIHR-LSEEQRVQVTSLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTK 399 ++++ E +VQ SLR G P P QS R Q+ R+ Sbjct: 271 CFFYISVYPGYGVEIKVQNISLREGETVTVEGLGGPDPLPLANQSFLLRG----QVIRSP 326 Query: 400 ELAVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIG 459 TH+ A+ F+S PG + + + L C P P G Sbjct: 327 -----THQA--ALRFQSLPPPAGPGTFHFHYQAYLLS---------CHFPRRPAYGDVTV 370 Query: 460 SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPS-GT 518 + G + +F C Y L+GA+ +TC + F W PVC + CG ++ + G Sbjct: 371 TSLHPGGSARFHCATGYQLKGARHLTCLNATQPF--WDSKEPVC-IAACGGVIRNATTGR 427 Query: 519 FTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVL 578 SP FP Y +N C W++ A + + ++FE+ L D L I +G V P V Sbjct: 428 IVSPGFPGNYSNNLTCHWLLEAPEGQR-LHLHFEKVSLAEDDDRLIIRNGDNVEAP-PVY 485 Query: 579 QVLTGSFVP-DLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDP---------G 628 ++P + ++S ++ L TD S + G + Y+ ++ C +P Sbjct: 486 DSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSS 545 Query: 629 TPLYGIREGDGFSNRDVLRFECQFGFEL-IGEKSIVCQE--NNQWSANIPICIFPCLSNF 685 TP Y + + F C G+ L G I C + + QW+ P C C Sbjct: 546 TPTYPV--------GTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEI 597 Query: 686 TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPES 745 T G VLSP++PE YG +CIW + + RI L + D L DGD + Sbjct: 598 TDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRI-GPGDVLTFYDGDDLTA 656 Query: 746 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMS----GRGFNITYNTFGHNE-CPD-PGI 799 +LG ++G L ++ + ++FQ+D S +GF I + N+ CP+ P I Sbjct: 657 RVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEI 716 Query: 800 PINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGG 857 P N + +L G+ ++ C G+ + G+ + C + WS +P C Sbjct: 717 P-NGWKSPSQPELVHGTVVTYQCYPGY-QVVGSSVLMC---QWDLTWSEDLPSCQRVTSC 771 Query: 858 HFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNL 917 H PG + S + G +++ ++ + +L HD Sbjct: 772 HD------------PGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQ-- 817 Query: 918 LSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIP 976 GS + P+ L + L +N + ++H T++ Sbjct: 818 ----AGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIH---------- 863 Query: 977 VHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNH--WWSHPLPTCDA 1025 FSC GY L + + C H WS P P C A Sbjct: 864 -----------------FSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRA 897 Score = 102 bits (254), Expect = 7e-21 Identities = 95/361 (26%), Positives = 151/361 (41%), Gaps = 19/361 (5%) Query: 2243 CGGNITAMNGTIYSPGYPDEYPNFQ-DCFWLVRVPPGNGIYI---NFTVLQTEPIYDFIT 2298 C N + G++ SP + DCF+ + V PG G+ I N ++ + E + + Sbjct: 244 CSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVT--VE 301 Query: 2299 VWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHS--DFTTSGFFVLSYHAYQLRVCQ 2356 GPD P Q S + + S ++Q ++F S G F Y AY L Sbjct: 302 GLGGPDP-LPLANQ-SFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHF 359 Query: 2357 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLC 2416 P P +T G R+ C G+ L G LTC + D PVC C Sbjct: 360 PRRPAYGDVTVTS---LHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAAC 416 Query: 2417 PANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2476 +R +TG I+SPG+P +Y N C W + +G + + E ++ D L + + Sbjct: 417 -GGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRN 475 Query: 2477 GPNIQS-PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAF---YCSTP 2532 G N+++ PV S +Y + S+G F++ S D G +RY AF +C P Sbjct: 476 GDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEP 535 Query: 2533 ESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISC 2592 + S + + V ++CD G+ L + S + W+ PAC+A+ Sbjct: 536 FVKYGNFSSSTPTYPVGTTVEFSCDPGYTL-EQGSIIIECVDPHDPQWNETEPACRAVCS 594 Query: 2593 G 2593 G Sbjct: 595 G 595 Score = 99.0 bits (245), Expect = 8e-20 Identities = 66/225 (29%), Positives = 103/225 (45%), Gaps = 9/225 (4%) Query: 22 IYTCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLS 80 I CGG ++ G I SPGFP Y N C W++ A E R+ + F+ +L E+ D L Sbjct: 413 IAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLI 472 Query: 81 LYDGH--PHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSC 138 + +G P + + + + S+ F + L++D + +A G + YE Q C Sbjct: 473 IRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHC 532 Query: 139 GNPGVPPKGVLYGT-RFDVGDKIRYSCVTGYILD-GHPQLTCIANSVNTASWDFPVPICR 196 P V T + VG + +SC GY L+ G + C+ + W+ P CR Sbjct: 533 YEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECV--DPHDPQWNETEPACR 590 Query: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISL 241 A C G + S+G++ SP++P Y DC W + E I L Sbjct: 591 A--VCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIML 633 Score = 95.9 bits (237), Expect = 7e-19 Identities = 130/552 (23%), Positives = 194/552 (35%), Gaps = 144/552 (26%) Query: 3015 TCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCL--ANGSWTGRQPEC--- 3069 +C P P +G ++ + R+ C TGY L G+ TCL W ++P C Sbjct: 356 SCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAA 415 Query: 3070 -----------KAVQCGNPGTTANG-----------------------------KVFRID 3089 + V G PG +N ++ + Sbjct: 416 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRN 475 Query: 3090 GTTFSSSVIYSC-------MEGYILSGPSV---RQCTANGTWSGTLPNCTIISCGDPGIP 3139 G + +Y +EG + SG ++G +G G P Sbjct: 476 GDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEP 535 Query: 3140 ANGLRYGD------DYVVGQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTCRAV 3191 ++YG+ Y VG V + C PGYT+E GS I C + W+ P CRAV Sbjct: 536 F--VKYGNFSSSTPTYPVGTTVEFSCDPGYTLE-QGSIIIECVDPHDPQWNETEPACRAV 592 Query: 3192 TCPTPPQISNGRLEGTNFD----------WGFSIS-----------YICSPGYELSF--P 3228 C S G + N+ WG + PG L+F Sbjct: 593 -CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDG 651 Query: 3229 AVLTCVGNGTWSG---------EVPQCLPKFCGDPGIPAQGKREG--------------- 3264 LT G +SG + +F DPG G ++G Sbjct: 652 DDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCP 711 Query: 3265 --------------KSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT 3310 ++ + V++ C + +VGSS +CQ D TWS P C T Sbjct: 712 ELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC--QRVT 769 Query: 3311 SCENPGVPRHGSQ-NNTFGFQVGSVVQFHCKKGHLLQGSTTRTC----LPDLTWSGIQPE 3365 SC +PG H + ++ F VG+ VQ+ C +G +L GS+ TC WS P+ Sbjct: 770 SCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPK 829 Query: 3366 CI------PHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR-VCRSDNT 3418 C+ H PE A + L G T+ ++C PG+ L G + V + Sbjct: 830 CLLEQLKPCHGLSAPENGARS--PEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSH 887 Query: 3419 WTGKVPICEAGS 3430 W+ PIC A S Sbjct: 888 WSDPPPICRAAS 899 Score = 95.1 bits (235), Expect = 1e-18 Identities = 138/570 (24%), Positives = 204/570 (35%), Gaps = 115/570 (20%) Query: 2590 ISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRC 2649 +SC P+ P G + T G + C GY+L T + + W + K P C Sbjct: 355 LSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDS--KEPVC 412 Query: 2650 VVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRN 2709 + C + I RIV+ PG+ G ++ C W Sbjct: 413 IAA-CGGV---IRNATTGRIVS---------------PGFPGNYSNNLTC------HWLL 447 Query: 2710 ERP-------YCQIISCGELPTP---PNGNKIGTQTSYGSTAIFTCDL-GFMLVGSAVRE 2758 E P + + +S E NG+ + Y S + + G + G Sbjct: 448 EAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFV 507 Query: 2759 CLS---SGLWSESETRCLA---GHCGIPELIV-NGQVIGENYGYRDTVVYQCNPGFRLIG 2811 LS SG + R A GHC P + N Y TV + C+PG+ L Sbjct: 508 ELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQ 567 Query: 2812 SSVRI-CQQDHN--WSGQLPSCVPV-------SCGHPGSPIYGRTSGNG------FNFND 2855 S+ I C H+ W+ P+C V S G SP + G G + + Sbjct: 568 GSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEE 627 Query: 2856 VVTFSCNIGYLMQGPTKA---------QCQANRQWSHPPPMCKVVNC---------SDPG 2897 +I L GP + Q+S P K+ SDPG Sbjct: 628 DKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPG 687 Query: 2898 ----------------IPANSKRESKIEHGN---------FTYGTVVFYDCNPGYFLFGS 2932 +P N E N +GTVV Y C PGY + GS Sbjct: 688 TSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGS 747 Query: 2933 SVLICQPNGQWDKPLPECIMI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLG 2989 SVL+CQ + W + LP C + C PG ++ ++S K+ G+TV Y C L+G Sbjct: 748 SVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMG 807 Query: 2990 QSSRTCQ----LNGHWSGSQPHCSGDATGTCGDPGTPGHGSR--QESNFRTKSTVRYACD 3043 S TC + WS P C + C P +G+R ++ +T+ ++C Sbjct: 808 SSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCA 867 Query: 3044 TGYILHGSEERTCLAN--GSWTGRQPECKA 3071 GY+L G C+ W+ P C+A Sbjct: 868 PGYVLKGQASIKCVPGHPSHWSDPPPICRA 897 Score = 86.7 bits (213), Expect = 4e-16 Identities = 153/607 (25%), Positives = 217/607 (35%), Gaps = 141/607 (23%) Query: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773 ++SC P G+ T G +A F C G+ L G+ CL++ W E C+ Sbjct: 354 LLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCI 413 Query: 2774 AGHCGIPELIVNGQVIGENY--GYRDTV----VYQCNPGFR--LIGSSVRICQQDHNW-- 2823 A G+ G+++ + Y + + + + G R L V + + D Sbjct: 414 AACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLII 473 Query: 2824 -SGQLPSCVPVSCGHPGS--PIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ 2880 +G PV + PI G S F ++ T S M +A Q Sbjct: 474 RNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQG--- 530 Query: 2881 WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF-----TY--GTVVFYDCNPGYFLFGSS 2933 +C +P +++GNF TY GT V + C+PGY L S Sbjct: 531 -----------HCYEP----------FVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGS 569 Query: 2934 VLI--CQPNG-QWDKPLPECIMIDCGHPGVPPNAVLS---GEKYTFGST----VHYSCTG 2983 ++I P+ QW++ P C + G VLS E Y G VH Sbjct: 570 IIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVE-ED 628 Query: 2984 KRSLL----------------GQSSRTCQLNGHWSGSQPH-----CSGDAT-GTCGDPGT 3021 KR +L T ++ G +SG + H D T DPGT Sbjct: 629 KRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGT 688 Query: 3022 PGHGSRQESNFRTKSTVRYACDTGYILHGSE---ERTC-----LANGSWTGRQPECKAVQ 3073 G +Q G+++H E TC + NG + QPE Sbjct: 689 SVLGYQQ----------------GFVIHFFEVPRNDTCPELPEIPNGWKSPSQPEL---- 728 Query: 3074 CGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC-TIIS 3132 + GT V Y C GY + G SV C + TWS LP+C + S Sbjct: 729 --------------VHGTV----VTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTS 770 Query: 3133 CGDPGIPANGLRY--GDDYVVGQNVSYMCQPGYTMELNGSRIRTC----TINGTWSGVMP 3186 C DPG + R + VG V Y+C G+ L GS I TC + WS P Sbjct: 771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFV--LMGSSILTCHDRQAGSPKWSDRAP 828 Query: 3187 TC---RAVTCPTPPQISNGRL--EGTNFDWGFSISYICSPGYELSFPAVLTCVGN--GTW 3239 C + C NG E G +I + C+PGY L A + CV W Sbjct: 829 KCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHW 888 Query: 3240 SGEVPQC 3246 S P C Sbjct: 889 SDPPPIC 895 Score = 79.3 bits (194), Expect = 6e-14 Identities = 79/291 (27%), Positives = 114/291 (39%), Gaps = 21/291 (7%) Query: 25 CGGTLKGLNGTIESPGFPYGYPN--GANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82 C G G+++SP P G +C + I ++I Q+ +L E Sbjct: 244 CSWNFSGPEGSLDSPT-DLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEG 302 Query: 83 DGHPHP---TNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 G P P N L G + P +LR S + G ++ + SC Sbjct: 303 LGGPDPLPLANQSFLLRGQVIRSPTHQA----ALRFQSLPPPAGPGTFHFHYQAYLLSCH 358 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 P P G + T G R+ C TGY L G LTC+ + WD P+C A Sbjct: 359 FPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCL--NATQPFWDSKEPVCIA-- 414 Query: 200 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIE 258 ACGG +R ++ G I SP FP Y NN C W + A G + L F + E D L I Sbjct: 415 ACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIR 474 Query: 259 GSE----PPTIWLSGMNIPP--PIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 + PP + P ++S+ + TDS+ G + Y+ Sbjct: 475 NGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYE 525 Score = 74.7 bits (182), Expect = 2e-12 Identities = 55/191 (28%), Positives = 82/191 (42%), Gaps = 16/191 (8%) Query: 2718 SCGELPTPPNGNKIGTQTS--YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCL-A 2774 +C ELP PNG K +Q +G+ + C G+ +VGS+V C WSE C Sbjct: 709 TCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRV 768 Query: 2775 GHCGIPELIVNGQ--VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH----NWSGQLP 2828 C P + + + + + TV Y C+ GF L+GSS+ C WS + P Sbjct: 769 TSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAP 828 Query: 2829 SCVPVS---CGHPGSPIYGRTSGNG--FNFNDVVTFSCNIGYLMQGPTKAQCQANR--QW 2881 C+ C +P G S + FSC GY+++G +C W Sbjct: 829 KCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHW 888 Query: 2882 SHPPPMCKVVN 2892 S PPP+C+ + Sbjct: 889 SDPPPICRAAS 899 Score = 58.5 bits (140), Expect = 1e-07 Identities = 48/203 (23%), Positives = 86/203 (42%), Gaps = 14/203 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 C G + G + SP +P Y G +C W + EE RI + + + D L+ YDG Sbjct: 593 CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-DVLTFYDG 651 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-----YYEELQSSSCG 139 + +G + ++ + +++ SD S G++ ++E ++ +C Sbjct: 652 DDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCP 711 Query: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 P G ++ ++ G + Y C GY + G L C + +W +P C+ Sbjct: 712 ELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD----LTWSEDLPSCQR 767 Query: 198 EDAC--GGTMRGSSGIISSPSFP 218 +C G + S +ISSP FP Sbjct: 768 VTSCHDPGDVEHSRRLISSPKFP 790 Score = 39.3 bits (90), Expect = 0.073 Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 2/60 (3%) Query: 157 GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPS 216 G I +SC GY+L G + C+ + + W P PICRA G S + +P+ Sbjct: 859 GATIHFSCAPGYVLKGQASIKCVPG--HPSHWSDPPPICRAASLDGFYNSRSLDVAKAPA 916 Score = 37.7 bits (86), Expect = 0.21 Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 8/105 (7%) Query: 136 SSCGNPG--VPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVP 193 +SC +PG + ++ +F VG ++Y C G++L G LTC + W P Sbjct: 769 TSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAP 828 Query: 194 ICRAED--ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPG 236 C E C G +G S P + + A T PG Sbjct: 829 KCLLEQLKPCHGLSAPENGARS----PEKQLHPAGATIHFSCAPG 869 >gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 [Homo sapiens] Length = 840 Score = 224 bits (570), Expect = 2e-57 Identities = 181/670 (27%), Positives = 291/670 (43%), Gaps = 36/670 (5%) Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2127 C +S+ G + SP +L DCT++I++ G+G+ +Q + + L + Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 2128 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185 G S ++ S L S T+ L+F S GF I YQAY L Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 222 Query: 2186 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2245 PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG Sbjct: 223 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 281 Query: 2246 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2304 I A G I SP C W++ G ++++F + + D + V G Sbjct: 282 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 341 Query: 2305 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2362 SP I + E + S + + ++ S+ + + L + A++ C P + Sbjct: 342 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 400 Query: 2363 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2418 + + T D E+ G + + CLPG+ L NAI C + P C+ +C Sbjct: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 458 Query: 2419 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2478 EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG Sbjct: 459 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 516 Query: 2479 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2534 + VL L G + S+G ++ LQ+ A G G ++ + P + Sbjct: 517 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575 Query: 2535 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2589 PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ Sbjct: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 631 Query: 2590 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2646 I +C P NG +D + VG+ V Y C GY L + T + GT ++ Sbjct: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691 Query: 2647 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS 2706 P+C + P +N + E+G ++ + HY+ + F C G+ +G +I C+P Sbjct: 692 PKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ 750 Query: 2707 WRNERPYCQI 2716 W ++ P C++ Sbjct: 751 WTSQPPLCKV 760 Score = 212 bits (540), Expect = 5e-54 Identities = 194/740 (26%), Positives = 292/740 (39%), Gaps = 79/740 (10%) Query: 1894 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1950 T V C +++ +G + SP P L +C + I V G GI++QV + Sbjct: 98 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 157 Query: 1951 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2008 + L GG APRL + S +L S +N L L+FQS GF + Y A Sbjct: 158 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217 Query: 2009 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067 L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C Sbjct: 218 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275 Query: 2068 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2126 +A CGG + + + G I+SP G +L C W I G +HL F S + +D L Sbjct: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335 Query: 2127 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185 VRSG S S VI +P L S + S+ N + ++A++ C Sbjct: 336 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 395 Query: 2186 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2240 P +G V D + G +F C PGY L +A+ C+ +WN P C+ Sbjct: 396 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454 Query: 2241 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300 A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++ Sbjct: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 513 Query: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2354 DG ++ + Q G + S+ + ++F + GF + + Sbjct: 514 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 573 Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414 C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ Sbjct: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 630 Query: 2415 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2474 + CA + G+ ++ F V Sbjct: 631 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 655 Query: 2475 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2531 G ++Q Y + G + +S D G K R+ A C Sbjct: 656 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 703 Query: 2532 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2590 P P +GY + + Q +R+ C GF L+G+ + C W + P C+ Sbjct: 704 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCKVT 761 Query: 2591 SCGIPKAPTNGGILTTDYLV 2610 P GG L L+ Sbjct: 762 QTTDPSRQLEGGNLALAILL 781 Score = 207 bits (528), Expect = 1e-52 Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%) Query: 855 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 911 C + S G + SP +L +C + I PG+ I+I + ++L + Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 912 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 969 G P L LL + + Q L S +N + L F + GF+IHY++ + S Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 219 Query: 970 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 1027 C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C Sbjct: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 279 Query: 1028 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1086 GG + + G I+SP +L C W ++ G+ + +F L++ +D L++ Sbjct: 280 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 339 Query: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1145 GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P Sbjct: 340 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 397 Query: 1146 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1201 + + + G TFSC GY LE + I C+ W+ P C A C Sbjct: 398 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 457 Query: 1202 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1261 G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG Sbjct: 458 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 517 Query: 1262 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1316 + +L G R LSS L L+F + G +GF L + + C + Sbjct: 518 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 576 Query: 1317 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1373 P++G++ + G G+ + Y C PGY L GS +L C +W P+C I Sbjct: 577 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 634 Query: 1374 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1432 C + + R S G+P RC+ PG SL+ A T S D Sbjct: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 682 Query: 1433 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1492 P +D + K A+++ C +PG Sbjct: 683 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 705 Query: 1493 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544 VP NG T + G+++ F C G+EL GE ITC+ W PP+C Sbjct: 706 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 758 Score = 206 bits (524), Expect = 3e-52 Identities = 190/781 (24%), Positives = 318/781 (40%), Gaps = 96/781 (12%) Query: 1381 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1437 E G + SP P L C + I V PG + +Q + ++L + G Sbjct: 109 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 168 Query: 1438 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495 + S++ EG + S N + + F + GF I + + + + C P P Sbjct: 169 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 227 Query: 1496 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1555 +G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + + Sbjct: 228 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 286 Query: 1556 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1614 + G I+SP + C W I + L F S++ + D L + G SP+ Sbjct: 287 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 346 Query: 1615 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1669 I +PER + S + ++++ S+ + L ++A + CF P GN+ Sbjct: 347 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 404 Query: 1670 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1726 T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG Sbjct: 405 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 461 Query: 1727 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1786 + G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG + Sbjct: 462 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 521 Query: 1787 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1842 +L+ L G L LSSG +T++F + P +GF ++ VPR + C +P Sbjct: 522 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 578 Query: 1843 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1900 P +G R + + G+ + + C PGY L GS + C QW+ S C Sbjct: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 630 Query: 1901 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1959 I+T ++ G+ D P G+ +Q + + ++ E Sbjct: 631 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 670 Query: 1960 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 2019 A L YS D + A+ + C P P Sbjct: 671 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 708 Query: 2020 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMS 2076 +G + Y G+ + F C +G+ L G ITC+PG +W P+C + Q Sbjct: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSR 768 Query: 2077 DFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETST 2136 G GN ++ + + +G GV++ + +++ + SGS S Sbjct: 769 QLEG--------GNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGSHSYSP 816 Query: 2137 V 2137 + Sbjct: 817 I 817 Score = 182 bits (463), Expect = 4e-45 Identities = 155/571 (27%), Positives = 239/571 (41%), Gaps = 31/571 (5%) Query: 1201 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1257 C + + EG + SP+ +C YSI V G GI I +T +L+Q + L + Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 1258 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1315 G +SM G L S +N+L L F S GF++ Y ++ LS C Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221 Query: 1316 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1375 P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG Sbjct: 222 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280 Query: 1376 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1435 G + GRI+SP NL C W+IE G + L F + +D L V G Sbjct: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340 Query: 1436 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1494 ++ + +PE G+ S + ++ ++ + +++F + C P + Sbjct: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400 Query: 1495 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1550 N T PG F C PGY L+ I C+ + W + P C A CGG Sbjct: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 459 Query: 1551 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1610 L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG Sbjct: 460 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 518 Query: 1611 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1663 ++ ++ + + R+ SS + L F++ GF L +K R ++C Sbjct: 519 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 578 Query: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH---- 1719 P T D G+ +TY C+ GY L G LTC W+ A P+C Sbjct: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 634 Query: 1720 -APCGSRSTGSEGTVLSPNYPKNYSVGHNCV 1749 A G + G T +P V + C+ Sbjct: 635 CADPGEIANGHR-TASDAGFPVGSHVQYRCL 664 Score = 171 bits (432), Expect = 2e-41 Identities = 193/787 (24%), Positives = 301/787 (38%), Gaps = 119/787 (15%) Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604 C N++ G++ SP+ P + DC ++I V Y I + + ++ + L + Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 1605 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1656 G +NS ++G Q + P +N + L F+S GF + Y+A Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 216 Query: 1657 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P Sbjct: 217 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 273 Query: 1717 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1772 SC A CG + G ++SP +VG N + F + SL + Sbjct: 274 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 331 Query: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832 D + V G + S ++ E +S + + S P ++A Sbjct: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 389 Query: 1833 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1887 +C + P G E+ G+ F C PGY L AI C V + Sbjct: 390 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 445 Query: 1888 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1947 WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV Sbjct: 446 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 504 Query: 1948 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 2003 D L +DG +A L G L S+ +L L FQ+ GF L Sbjct: 505 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 564 Query: 2004 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060 + + D+CPE P G + + G V+++QC+ GY L G +TC W Sbjct: 565 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 622 Query: 2061 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2120 + P C I++ PG + P+G H+Q+ + Sbjct: 623 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 668 Query: 2121 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2180 + + S +T T K + A + Sbjct: 669 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 697 Query: 2181 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238 + C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P Sbjct: 698 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757 Query: 2239 CEA---------LCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQ 2289 C+ L GGN+ I P LV + G+G+YI +T LQ Sbjct: 758 CKVTQTTDPSRQLEGGNLAL---AILLP------------LGLV-IVLGSGVYIYYTKLQ 801 Query: 2290 TEPIYDF 2296 + ++ F Sbjct: 802 GKSLFGF 808 Score = 167 bits (422), Expect = 2e-40 Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%) Query: 508 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 C +N+ G SP+ C + I V I+I + +L + L Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 161 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 + GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC Sbjct: 162 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 220 Query: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 682 G P P +G F C G++L GE++++C + W+ P C+ C Sbjct: 221 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280 Query: 683 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 741 A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G Sbjct: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340 Query: 742 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 800 SP SP++ +VP L S++ L +E ++ + ++ + F + C P + Sbjct: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400 Query: 801 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 858 N ++ G+ + C G+ ++ G + + W+ P C A CGG Sbjct: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 460 Query: 859 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 918 S P+GV+LSP WP Y +C W + + I + E D+L + DG Sbjct: 461 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 519 Query: 919 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 974 + +L G Q + L SS + L F N GF +H++ V N +C + Sbjct: 520 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 578 Query: 975 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 1028 P G R D G+ +++ C+ GY L + L C+ + WS P C + C Sbjct: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 638 Query: 1029 GDVRGPSGTILSPGYP 1044 G++ T G+P Sbjct: 639 GEIANGHRTASDAGFP 654 Score = 122 bits (307), Expect = 5e-27 Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C P P +G +D G T F CD Y LQG +++ C + +W+ P C + Sbjct: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 276 Query: 506 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 +CG + + G SP N C WVI A + + ++FE L+ D L Sbjct: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 335 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 620 + GG P V+ S + D+ ++S + +++ L ++ + + ++ E Sbjct: 336 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 390 Query: 621 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 674 ++ C P + D + + F C G+ L +I C + + W+ Sbjct: 391 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 450 Query: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 734 P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D Sbjct: 451 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 509 Query: 735 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 790 L + DGD P + +L G + L S+ L L+FQA + G+GF + + Sbjct: 510 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 569 Query: 791 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 847 N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS Sbjct: 570 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 625 Query: 848 IPKC 851 P C Sbjct: 626 PPAC 629 Score = 89.0 bits (219), Expect = 8e-17 Identities = 62/203 (30%), Positives = 85/203 (41%), Gaps = 12/203 (5%) Query: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951 N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C Sbjct: 571 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 630 Query: 2952 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3004 I C PG N S + GS V Y C SL G + TC WS Sbjct: 631 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 690 Query: 3005 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3060 P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+ Sbjct: 691 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 749 Query: 3061 SWTGRQPECKAVQCGNPGTTANG 3083 WT + P CK Q +P G Sbjct: 750 QWTSQPPLCKVTQTTDPSRQLEG 772 Score = 85.9 bits (211), Expect = 7e-16 Identities = 63/195 (32%), Positives = 89/195 (45%), Gaps = 21/195 (10%) Query: 3079 TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC-TIISCGDPG 3137 T ++G + R GT + Y C GY L G + C + +WS P C I++C DPG Sbjct: 586 TASHGDLIR--GTVLT----YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPG 639 Query: 3138 IPANGLRYGDD--YVVGQNVSYMCQPGYTMELNGSRIRTCTINGT----WSGVMPTC--R 3189 ANG R D + VG +V Y C PGY++E G+ + TC T WS +P C + Sbjct: 640 EIANGHRTASDAGFPVGSHVQYRCLPGYSLE--GAAMLTCYSRDTGTPKWSDRVPKCALK 697 Query: 3190 AVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGN--GTWSGEVPQ 3245 C P NG L ++ G S+ + C G+EL +TCV W+ + P Sbjct: 698 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757 Query: 3246 CLPKFCGDPGIPAQG 3260 C DP +G Sbjct: 758 CKVTQTTDPSRQLEG 772 Score = 83.2 bits (204), Expect = 4e-15 Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%) Query: 3192 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248 TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C Sbjct: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632 Query: 3249 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3302 C DPG A G R F S V + C + L G++ C + T WS P Sbjct: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692 Query: 3303 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3359 C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W Sbjct: 693 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751 Query: 3360 SGIQPEC 3366 + P C Sbjct: 752 TSQPPLC 758 Score = 82.4 bits (202), Expect = 7e-15 Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%) Query: 2796 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2851 R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF Sbjct: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 653 Query: 2852 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2905 V + C GY ++G C + +WS P C K C +PG+P N + Sbjct: 654 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 713 Query: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2950 H + G + + C G+ L G + C P QW P C Sbjct: 714 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758 Score = 73.6 bits (179), Expect = 3e-12 Identities = 63/245 (25%), Positives = 97/245 (39%), Gaps = 37/245 (15%) Query: 2718 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA- 2774 +C ELP P G + + G+ + C+ G+ L+GS + C WS + C Sbjct: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632 Query: 2775 GHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLP 2828 C P I NG + G+ V Y+C PG+ L G+++ C WS ++P Sbjct: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692 Query: 2829 SCVPV--SCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2882 C C +PG P G + + + + + F C G+ + G C QW+ Sbjct: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 752 Query: 2883 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY--------------GTVVFYDCNPGYF 2928 PP+CKV +DP ++E GN G ++Y G Sbjct: 753 SQPPLCKVTQTTDP--------SRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKS 804 Query: 2929 LFGSS 2933 LFG S Sbjct: 805 LFGFS 809 Score = 69.7 bits (169), Expect = 5e-11 Identities = 76/278 (27%), Positives = 113/278 (40%), Gaps = 16/278 (5%) Query: 25 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 C + G +ESP G P G +CT+ I I+I Q+ L +E + L L Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 82 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 G R L + S + L S GF+++Y+ S CG Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 P P G + T G + C +GY L G L C+ + SW+ P C A Sbjct: 222 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 277 Query: 200 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 257 +CGGT+ ++ G I SP N C W I A G + L F ++E D L + Sbjct: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337 Query: 258 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 291 G P P I+ S M+ P +IS+ L + ++++ Sbjct: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 375 Score = 68.2 bits (165), Expect = 1e-10 Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 12/259 (4%) Query: 24 TCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82 +CGGT+ G I SP C WVI A E R+ + F+ +L+E+ D L + Sbjct: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337 Query: 83 DGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 G P + + + ++ +S++ + L S+ + + +E + C Sbjct: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRFEAFEEDRCFA 396 Query: 141 PGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTASWDFPVPICR 196 P + V + G +SC+ GY L+ G P + C+ W+ P C+ Sbjct: 397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACK 454 Query: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE 256 A CGG + +G++ SP +P Y DC W + + I L + E Sbjct: 455 A--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 512 Query: 257 IEGSEPPTIWLSGMNIPPP 275 +G P L+ + P P Sbjct: 513 FDGDGPSARVLAQLRGPQP 531 Score = 57.0 bits (136), Expect = 3e-07 Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG Sbjct: 457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 515 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 139 +L G + S+ +L+ + GF ++++E+ ++ +C Sbjct: 516 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575 Query: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 P G + D+ G + Y C GY L G LTC + SW P C+ Sbjct: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 631 Query: 198 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 227 C G + S FP H C Sbjct: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 663 Score = 53.5 bits (127), Expect = 4e-06 Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%) Query: 2956 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 3015 G PG+ P + + G + S T + L QS R + G Q + + Sbjct: 166 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 219 Query: 3016 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 3072 CG P P HG ++ T + CD+GY L G E CL NG SW G P C A Sbjct: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 277 Query: 3073 QCGNPGTTANGKVFRI 3088 CG GT N + RI Sbjct: 278 SCG--GTIHNATLGRI 291 Score = 52.8 bits (125), Expect = 6e-06 Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%) Query: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C Sbjct: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694 Query: 504 KVK 506 +K Sbjct: 695 ALK 697 Score = 52.0 bits (123), Expect = 1e-05 Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%) Query: 3307 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3365 P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P Sbjct: 569 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 628 Query: 3366 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3418 C +C P A+ A+ G + SH + Y C PG+ L G C S +T Sbjct: 629 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 684 Query: 3419 --WTGKVPIC 3426 W+ +VP C Sbjct: 685 PKWSDRVPKC 694 Score = 48.5 bits (114), Expect = 1e-04 Identities = 45/187 (24%), Positives = 71/187 (37%), Gaps = 18/187 (9%) Query: 2529 CSTPESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587 C+ P +G+ S G + S V++ C G+ L G + C G W VP C Sbjct: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694 Query: 2588 --QAISCGIPKAPTNG--GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2643 + C P P NG + Y G + +FC +G+ L + T V W++ Sbjct: 695 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 754 Query: 2644 NKTPRCVVVTCPSIN--------SFILEHGRWRIVNGSHYEYKTKV----VFSCDPGYHG 2691 + T PS + +L G ++ Y Y TK+ +F G H Sbjct: 755 PPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS-GSHS 813 Query: 2692 LGPASIE 2698 P ++E Sbjct: 814 YSPITVE 820 Score = 44.3 bits (103), Expect = 0.002 Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%) Query: 137 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 +C +PG G F VG ++Y C+ GY L+G LTC + T W VP Sbjct: 634 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 693 Query: 195 C 195 C Sbjct: 694 C 694 Score = 44.3 bits (103), Expect = 0.002 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%) Query: 133 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W Sbjct: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 753 Query: 191 PVPICR 196 P+C+ Sbjct: 754 QPPLCK 759 Score = 42.0 bits (97), Expect = 0.011 Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%) Query: 3191 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3247 ++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+ Sbjct: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 276 Query: 3248 PKFCG 3252 CG Sbjct: 277 AS-CG 280 Score = 41.2 bits (95), Expect = 0.019 Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%) Query: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773 ++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+ Sbjct: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276 Query: 2774 AGHCGIPELIVNGQVIGENYG 2794 A G G+++ G Sbjct: 277 ASCGGTIHNATLGRIVSPEPG 297 Score = 41.2 bits (95), Expect = 0.019 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%) Query: 619 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 674 ++ E C +PG P G + + + LRF C GFELIGE +I C +QW++ Sbjct: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 755 Query: 675 PIC 677 P+C Sbjct: 756 PLC 758 Score = 40.4 bits (93), Expect = 0.033 Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%) Query: 3311 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3367 SC P P HG + T G FHC G+ LQG T CL +W+G P C+ Sbjct: 219 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276 Score = 40.4 bits (93), Expect = 0.033 Identities = 39/148 (26%), Positives = 55/148 (37%), Gaps = 27/148 (18%) Query: 1659 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P Sbjct: 699 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 756 Query: 1717 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1776 C V P G N +I +P V+ L V Sbjct: 757 LC-------------KVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 794 Query: 1777 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1804 +Y Q SL SGSHS + + S Sbjct: 795 IYYTKLQGKSLF-GFSGSHSYSPITVES 821 Score = 38.5 bits (88), Expect = 0.12 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%) Query: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3186 ++SCG P PA+G D G ++ C GY +L G C +NGT W+G P Sbjct: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 273 Query: 3187 TCRAVTCPTPPQISNGRL 3204 +C A T + GR+ Sbjct: 274 SCMASCGGTIHNATLGRI 291 Score = 38.5 bits (88), Expect = 0.12 Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%) Query: 2777 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH--NWSGQLPSCVPVS 2834 CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S Sbjct: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 278 Query: 2835 CG 2836 CG Sbjct: 279 CG 280 Score = 38.5 bits (88), Expect = 0.12 Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%) Query: 446 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C Sbjct: 701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 758 Query: 504 KV 505 KV Sbjct: 759 KV 760 Score = 35.8 bits (81), Expect = 0.80 Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%) Query: 2833 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2888 +SCG P P +G S + TF C+ GY +QG C W+ P C Sbjct: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275 Score = 35.0 bits (79), Expect = 1.4 Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%) Query: 2949 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 3005 + ++ CG P P + +S G T + C L G+ + C LNG W+G Sbjct: 214 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 272 Query: 3006 PHCSGDATGT 3015 P C GT Sbjct: 273 PSCMASCGGT 282 Score = 34.3 bits (77), Expect = 2.3 Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%) Query: 3370 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3427 SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C Sbjct: 219 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 276 Query: 3428 A 3428 A Sbjct: 277 A 277 Score = 33.1 bits (74), Expect = 5.2 Identities = 16/38 (42%), Positives = 19/38 (50%), Gaps = 1/38 (2%) Query: 2683 FSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCG 2720 F CD GY G ++ CL SW E P C + SCG Sbjct: 244 FHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MASCG 280 Score = 32.7 bits (73), Expect = 6.8 Identities = 20/73 (27%), Positives = 39/73 (53%), Gaps = 5/73 (6%) Query: 3573 MSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVHEN 3630 +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G + Sbjct: 760 VTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSP 816 Query: 3631 NNGQAAFENPMYD 3643 ++ F NP+Y+ Sbjct: 817 ITVESDFSNPLYE 829 >gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 [Homo sapiens] Length = 910 Score = 224 bits (570), Expect = 2e-57 Identities = 181/670 (27%), Positives = 291/670 (43%), Gaps = 36/670 (5%) Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2127 C +S+ G + SP +L DCT++I++ G+G+ +Q + + L + Sbjct: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232 Query: 2128 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185 G S ++ S L S T+ L+F S GF I YQAY L Sbjct: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 292 Query: 2186 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2245 PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG Sbjct: 293 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 351 Query: 2246 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2304 I A G I SP C W++ G ++++F + + D + V G Sbjct: 352 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 411 Query: 2305 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2362 SP I + E + S + + ++ S+ + + L + A++ C P + Sbjct: 412 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 470 Query: 2363 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2418 + + T D E+ G + + CLPG+ L NAI C + P C+ +C Sbjct: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 528 Query: 2419 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2478 EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG Sbjct: 529 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 586 Query: 2479 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2534 + VL L G + S+G ++ LQ+ A G G ++ + P + Sbjct: 587 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 645 Query: 2535 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2589 PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ Sbjct: 646 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 701 Query: 2590 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2646 I +C P NG +D + VG+ V Y C GY L + T + GT ++ Sbjct: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 761 Query: 2647 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS 2706 P+C + P +N + E+G ++ + HY+ + F C G+ +G +I C+P Sbjct: 762 PKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ 820 Query: 2707 WRNERPYCQI 2716 W ++ P C++ Sbjct: 821 WTSQPPLCKV 830 Score = 212 bits (540), Expect = 5e-54 Identities = 194/740 (26%), Positives = 292/740 (39%), Gaps = 79/740 (10%) Query: 1894 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1950 T V C +++ +G + SP P L +C + I V G GI++QV + Sbjct: 168 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 227 Query: 1951 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2008 + L GG APRL + S +L S +N L L+FQS GF + Y A Sbjct: 228 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 287 Query: 2009 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067 L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C Sbjct: 288 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345 Query: 2068 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2126 +A CGG + + + G I+SP G +L C W I G +HL F S + +D L Sbjct: 346 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 405 Query: 2127 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185 VRSG S S VI +P L S + S+ N + ++A++ C Sbjct: 406 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 465 Query: 2186 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2240 P +G V D + G +F C PGY L +A+ C+ +WN P C+ Sbjct: 466 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 524 Query: 2241 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300 A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++ Sbjct: 525 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 583 Query: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2354 DG ++ + Q G + S+ + ++F + GF + + Sbjct: 584 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 643 Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414 C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ Sbjct: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 700 Query: 2415 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2474 + CA + G+ ++ F V Sbjct: 701 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 725 Query: 2475 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2531 G ++Q Y + G + +S D G K R+ A C Sbjct: 726 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 773 Query: 2532 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2590 P P +GY + + Q +R+ C GF L+G+ + C W + P C+ Sbjct: 774 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCKVT 831 Query: 2591 SCGIPKAPTNGGILTTDYLV 2610 P GG L L+ Sbjct: 832 QTTDPSRQLEGGNLALAILL 851 Score = 207 bits (528), Expect = 1e-52 Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%) Query: 855 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 911 C + S G + SP +L +C + I PG+ I+I + ++L + Sbjct: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232 Query: 912 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 969 G P L LL + + Q L S +N + L F + GF+IHY++ + S Sbjct: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 289 Query: 970 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 1027 C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C Sbjct: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 349 Query: 1028 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1086 GG + + G I+SP +L C W ++ G+ + +F L++ +D L++ Sbjct: 350 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 409 Query: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1145 GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P Sbjct: 410 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 467 Query: 1146 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1201 + + + G TFSC GY LE + I C+ W+ P C A C Sbjct: 468 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 527 Query: 1202 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1261 G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG Sbjct: 528 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 587 Query: 1262 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1316 + +L G R LSS L L+F + G +GF L + + C + Sbjct: 588 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 646 Query: 1317 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1373 P++G++ + G G+ + Y C PGY L GS +L C +W P+C I Sbjct: 647 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 704 Query: 1374 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1432 C + + R S G+P RC+ PG SL+ A T S D Sbjct: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 752 Query: 1433 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1492 P +D + K A+++ C +PG Sbjct: 753 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 775 Query: 1493 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544 VP NG T + G+++ F C G+EL GE ITC+ W PP+C Sbjct: 776 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 828 Score = 206 bits (524), Expect = 3e-52 Identities = 190/781 (24%), Positives = 318/781 (40%), Gaps = 96/781 (12%) Query: 1381 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1437 E G + SP P L C + I V PG + +Q + ++L + G Sbjct: 179 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 238 Query: 1438 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495 + S++ EG + S N + + F + GF I + + + + C P P Sbjct: 239 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 297 Query: 1496 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1555 +G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + + Sbjct: 298 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 356 Query: 1556 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1614 + G I+SP + C W I + L F S++ + D L + G SP+ Sbjct: 357 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 416 Query: 1615 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1669 I +PER + S + ++++ S+ + L ++A + CF P GN+ Sbjct: 417 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 474 Query: 1670 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1726 T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG Sbjct: 475 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 531 Query: 1727 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1786 + G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG + Sbjct: 532 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 591 Query: 1787 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1842 +L+ L G L LSSG +T++F + P +GF ++ VPR + C +P Sbjct: 592 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 648 Query: 1843 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1900 P +G R + + G+ + + C PGY L GS + C QW+ S C Sbjct: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 700 Query: 1901 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1959 I+T ++ G+ D P G+ +Q + + ++ E Sbjct: 701 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 740 Query: 1960 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 2019 A L YS D + A+ + C P P Sbjct: 741 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 778 Query: 2020 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMS 2076 +G + Y G+ + F C +G+ L G ITC+PG +W P+C + Q Sbjct: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSR 838 Query: 2077 DFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETST 2136 G GN ++ + + +G GV++ + +++ + SGS S Sbjct: 839 QLEG--------GNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGSHSYSP 886 Query: 2137 V 2137 + Sbjct: 887 I 887 Score = 182 bits (463), Expect = 4e-45 Identities = 155/571 (27%), Positives = 239/571 (41%), Gaps = 31/571 (5%) Query: 1201 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1257 C + + EG + SP+ +C YSI V G GI I +T +L+Q + L + Sbjct: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232 Query: 1258 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1315 G +SM G L S +N+L L F S GF++ Y ++ LS C Sbjct: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 291 Query: 1316 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1375 P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG Sbjct: 292 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350 Query: 1376 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1435 G + GRI+SP NL C W+IE G + L F + +D L V G Sbjct: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410 Query: 1436 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1494 ++ + +PE G+ S + ++ ++ + +++F + C P + Sbjct: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470 Query: 1495 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1550 N T PG F C PGY L+ I C+ + W + P C A CGG Sbjct: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 529 Query: 1551 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1610 L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG Sbjct: 530 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 588 Query: 1611 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1663 ++ ++ + + R+ SS + L F++ GF L +K R ++C Sbjct: 589 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 648 Query: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH---- 1719 P T D G+ +TY C+ GY L G LTC W+ A P+C Sbjct: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 704 Query: 1720 -APCGSRSTGSEGTVLSPNYPKNYSVGHNCV 1749 A G + G T +P V + C+ Sbjct: 705 CADPGEIANGHR-TASDAGFPVGSHVQYRCL 734 Score = 171 bits (432), Expect = 2e-41 Identities = 193/787 (24%), Positives = 301/787 (38%), Gaps = 119/787 (15%) Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604 C N++ G++ SP+ P + DC ++I V Y I + + ++ + L + Sbjct: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232 Query: 1605 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1656 G +NS ++G Q + P +N + L F+S GF + Y+A Sbjct: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 286 Query: 1657 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P Sbjct: 287 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 343 Query: 1717 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1772 SC A CG + G ++SP +VG N + F + SL + Sbjct: 344 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 401 Query: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832 D + V G + S ++ E +S + + S P ++A Sbjct: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 459 Query: 1833 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1887 +C + P G E+ G+ F C PGY L AI C V + Sbjct: 460 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 515 Query: 1888 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1947 WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV Sbjct: 516 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 574 Query: 1948 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 2003 D L +DG +A L G L S+ +L L FQ+ GF L Sbjct: 575 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 634 Query: 2004 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060 + + D+CPE P G + + G V+++QC+ GY L G +TC W Sbjct: 635 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 692 Query: 2061 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2120 + P C I++ PG + P+G H+Q+ + Sbjct: 693 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 738 Query: 2121 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2180 + + S +T T K + A + Sbjct: 739 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 767 Query: 2181 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238 + C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P Sbjct: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827 Query: 2239 CEA---------LCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQ 2289 C+ L GGN+ I P LV + G+G+YI +T LQ Sbjct: 828 CKVTQTTDPSRQLEGGNLAL---AILLP------------LGLV-IVLGSGVYIYYTKLQ 871 Query: 2290 TEPIYDF 2296 + ++ F Sbjct: 872 GKSLFGF 878 Score = 167 bits (422), Expect = 2e-40 Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%) Query: 508 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 C +N+ G SP+ C + I V I+I + +L + L Sbjct: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 231 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 + GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC Sbjct: 232 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 290 Query: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 682 G P P +G F C G++L GE++++C + W+ P C+ C Sbjct: 291 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350 Query: 683 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 741 A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G Sbjct: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410 Query: 742 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 800 SP SP++ +VP L S++ L +E ++ + ++ + F + C P + Sbjct: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470 Query: 801 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 858 N ++ G+ + C G+ ++ G + + W+ P C A CGG Sbjct: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 530 Query: 859 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 918 S P+GV+LSP WP Y +C W + + I + E D+L + DG Sbjct: 531 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 589 Query: 919 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 974 + +L G Q + L SS + L F N GF +H++ V N +C + Sbjct: 590 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 648 Query: 975 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 1028 P G R D G+ +++ C+ GY L + L C+ + WS P C + C Sbjct: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 708 Query: 1029 GDVRGPSGTILSPGYP 1044 G++ T G+P Sbjct: 709 GEIANGHRTASDAGFP 724 Score = 122 bits (307), Expect = 5e-27 Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C P P +G +D G T F CD Y LQG +++ C + +W+ P C + Sbjct: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 346 Query: 506 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 +CG + + G SP N C WVI A + + ++FE L+ D L Sbjct: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 405 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 620 + GG P V+ S + D+ ++S + +++ L ++ + + ++ E Sbjct: 406 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 460 Query: 621 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 674 ++ C P + D + + F C G+ L +I C + + W+ Sbjct: 461 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 520 Query: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 734 P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D Sbjct: 521 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 579 Query: 735 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 790 L + DGD P + +L G + L S+ L L+FQA + G+GF + + Sbjct: 580 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 639 Query: 791 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 847 N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS Sbjct: 640 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 695 Query: 848 IPKC 851 P C Sbjct: 696 PPAC 699 Score = 89.0 bits (219), Expect = 8e-17 Identities = 62/203 (30%), Positives = 85/203 (41%), Gaps = 12/203 (5%) Query: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951 N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C Sbjct: 641 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 700 Query: 2952 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3004 I C PG N S + GS V Y C SL G + TC WS Sbjct: 701 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 760 Query: 3005 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3060 P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+ Sbjct: 761 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 819 Query: 3061 SWTGRQPECKAVQCGNPGTTANG 3083 WT + P CK Q +P G Sbjct: 820 QWTSQPPLCKVTQTTDPSRQLEG 842 Score = 85.9 bits (211), Expect = 7e-16 Identities = 63/195 (32%), Positives = 89/195 (45%), Gaps = 21/195 (10%) Query: 3079 TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC-TIISCGDPG 3137 T ++G + R GT + Y C GY L G + C + +WS P C I++C DPG Sbjct: 656 TASHGDLIR--GTVLT----YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPG 709 Query: 3138 IPANGLRYGDD--YVVGQNVSYMCQPGYTMELNGSRIRTCTINGT----WSGVMPTC--R 3189 ANG R D + VG +V Y C PGY++E G+ + TC T WS +P C + Sbjct: 710 EIANGHRTASDAGFPVGSHVQYRCLPGYSLE--GAAMLTCYSRDTGTPKWSDRVPKCALK 767 Query: 3190 AVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGN--GTWSGEVPQ 3245 C P NG L ++ G S+ + C G+EL +TCV W+ + P Sbjct: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827 Query: 3246 CLPKFCGDPGIPAQG 3260 C DP +G Sbjct: 828 CKVTQTTDPSRQLEG 842 Score = 83.2 bits (204), Expect = 4e-15 Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%) Query: 3192 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248 TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C Sbjct: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702 Query: 3249 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3302 C DPG A G R F S V + C + L G++ C + T WS P Sbjct: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762 Query: 3303 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3359 C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W Sbjct: 763 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 821 Query: 3360 SGIQPEC 3366 + P C Sbjct: 822 TSQPPLC 828 Score = 82.4 bits (202), Expect = 7e-15 Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%) Query: 2796 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2851 R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF Sbjct: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 723 Query: 2852 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2905 V + C GY ++G C + +WS P C K C +PG+P N + Sbjct: 724 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 783 Query: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2950 H + G + + C G+ L G + C P QW P C Sbjct: 784 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 828 Score = 73.6 bits (179), Expect = 3e-12 Identities = 63/245 (25%), Positives = 97/245 (39%), Gaps = 37/245 (15%) Query: 2718 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA- 2774 +C ELP P G + + G+ + C+ G+ L+GS + C WS + C Sbjct: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702 Query: 2775 GHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLP 2828 C P I NG + G+ V Y+C PG+ L G+++ C WS ++P Sbjct: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762 Query: 2829 SCVPV--SCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2882 C C +PG P G + + + + + F C G+ + G C QW+ Sbjct: 763 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 822 Query: 2883 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY--------------GTVVFYDCNPGYF 2928 PP+CKV +DP ++E GN G ++Y G Sbjct: 823 SQPPLCKVTQTTDP--------SRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKS 874 Query: 2929 LFGSS 2933 LFG S Sbjct: 875 LFGFS 879 Score = 69.7 bits (169), Expect = 5e-11 Identities = 76/278 (27%), Positives = 113/278 (40%), Gaps = 16/278 (5%) Query: 25 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 C + G +ESP G P G +CT+ I I+I Q+ L +E + L L Sbjct: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232 Query: 82 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 G R L + S + L S GF+++Y+ S CG Sbjct: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 291 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 P P G + T G + C +GY L G L C+ + SW+ P C A Sbjct: 292 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 347 Query: 200 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 257 +CGGT+ ++ G I SP N C W I A G + L F ++E D L + Sbjct: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407 Query: 258 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 291 G P P I+ S M+ P +IS+ L + ++++ Sbjct: 408 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 445 Score = 68.2 bits (165), Expect = 1e-10 Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 12/259 (4%) Query: 24 TCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82 +CGGT+ G I SP C WVI A E R+ + F+ +L+E+ D L + Sbjct: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407 Query: 83 DGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 G P + + + ++ +S++ + L S+ + + +E + C Sbjct: 408 SGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRFEAFEEDRCFA 466 Query: 141 PGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTASWDFPVPICR 196 P + V + G +SC+ GY L+ G P + C+ W+ P C+ Sbjct: 467 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACK 524 Query: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE 256 A CGG + +G++ SP +P Y DC W + + I L + E Sbjct: 525 A--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 582 Query: 257 IEGSEPPTIWLSGMNIPPP 275 +G P L+ + P P Sbjct: 583 FDGDGPSARVLAQLRGPQP 601 Score = 57.0 bits (136), Expect = 3e-07 Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG Sbjct: 527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 585 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 139 +L G + S+ +L+ + GF ++++E+ ++ +C Sbjct: 586 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 645 Query: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 P G + D+ G + Y C GY L G LTC + SW P C+ Sbjct: 646 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 701 Query: 198 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 227 C G + S FP H C Sbjct: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 733 Score = 53.5 bits (127), Expect = 4e-06 Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%) Query: 2956 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 3015 G PG+ P + + G + S T + L QS R + G Q + + Sbjct: 236 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 289 Query: 3016 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 3072 CG P P HG ++ T + CD+GY L G E CL NG SW G P C A Sbjct: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 347 Query: 3073 QCGNPGTTANGKVFRI 3088 CG GT N + RI Sbjct: 348 SCG--GTIHNATLGRI 361 Score = 52.8 bits (125), Expect = 6e-06 Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%) Query: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C Sbjct: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 764 Query: 504 KVK 506 +K Sbjct: 765 ALK 767 Score = 52.0 bits (123), Expect = 1e-05 Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%) Query: 3307 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3365 P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P Sbjct: 639 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 698 Query: 3366 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3418 C +C P A+ A+ G + SH + Y C PG+ L G C S +T Sbjct: 699 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 754 Query: 3419 --WTGKVPIC 3426 W+ +VP C Sbjct: 755 PKWSDRVPKC 764 Score = 48.5 bits (114), Expect = 1e-04 Identities = 45/187 (24%), Positives = 71/187 (37%), Gaps = 18/187 (9%) Query: 2529 CSTPESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587 C+ P +G+ S G + S V++ C G+ L G + C G W VP C Sbjct: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 764 Query: 2588 --QAISCGIPKAPTNG--GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2643 + C P P NG + Y G + +FC +G+ L + T V W++ Sbjct: 765 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 824 Query: 2644 NKTPRCVVVTCPSIN--------SFILEHGRWRIVNGSHYEYKTKV----VFSCDPGYHG 2691 + T PS + +L G ++ Y Y TK+ +F G H Sbjct: 825 PPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS-GSHS 883 Query: 2692 LGPASIE 2698 P ++E Sbjct: 884 YSPITVE 890 Score = 44.3 bits (103), Expect = 0.002 Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%) Query: 137 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 +C +PG G F VG ++Y C+ GY L+G LTC + T W VP Sbjct: 704 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 763 Query: 195 C 195 C Sbjct: 764 C 764 Score = 44.3 bits (103), Expect = 0.002 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%) Query: 133 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W Sbjct: 766 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 823 Query: 191 PVPICR 196 P+C+ Sbjct: 824 QPPLCK 829 Score = 42.0 bits (97), Expect = 0.011 Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%) Query: 3191 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3247 ++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+ Sbjct: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 346 Query: 3248 PKFCG 3252 CG Sbjct: 347 AS-CG 350 Score = 41.2 bits (95), Expect = 0.019 Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%) Query: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773 ++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+ Sbjct: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346 Query: 2774 AGHCGIPELIVNGQVIGENYG 2794 A G G+++ G Sbjct: 347 ASCGGTIHNATLGRIVSPEPG 367 Score = 41.2 bits (95), Expect = 0.019 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%) Query: 619 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 674 ++ E C +PG P G + + + LRF C GFELIGE +I C +QW++ Sbjct: 766 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 825 Query: 675 PIC 677 P+C Sbjct: 826 PLC 828 Score = 40.4 bits (93), Expect = 0.033 Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%) Query: 3311 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3367 SC P P HG + T G FHC G+ LQG T CL +W+G P C+ Sbjct: 289 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346 Score = 40.4 bits (93), Expect = 0.033 Identities = 39/148 (26%), Positives = 55/148 (37%), Gaps = 27/148 (18%) Query: 1659 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P Sbjct: 769 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 826 Query: 1717 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1776 C V P G N +I +P V+ L V Sbjct: 827 LC-------------KVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 864 Query: 1777 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1804 +Y Q SL SGSHS + + S Sbjct: 865 IYYTKLQGKSLF-GFSGSHSYSPITVES 891 Score = 38.5 bits (88), Expect = 0.12 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%) Query: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3186 ++SCG P PA+G D G ++ C GY +L G C +NGT W+G P Sbjct: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 343 Query: 3187 TCRAVTCPTPPQISNGRL 3204 +C A T + GR+ Sbjct: 344 SCMASCGGTIHNATLGRI 361 Score = 38.5 bits (88), Expect = 0.12 Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%) Query: 2777 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH--NWSGQLPSCVPVS 2834 CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S Sbjct: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 348 Query: 2835 CG 2836 CG Sbjct: 349 CG 350 Score = 38.5 bits (88), Expect = 0.12 Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%) Query: 446 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C Sbjct: 771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 828 Query: 504 KV 505 KV Sbjct: 829 KV 830 Score = 35.8 bits (81), Expect = 0.80 Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%) Query: 2833 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2888 +SCG P P +G S + TF C+ GY +QG C W+ P C Sbjct: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345 Score = 35.0 bits (79), Expect = 1.4 Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%) Query: 2949 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 3005 + ++ CG P P + +S G T + C L G+ + C LNG W+G Sbjct: 284 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 342 Query: 3006 PHCSGDATGT 3015 P C GT Sbjct: 343 PSCMASCGGT 352 Score = 34.3 bits (77), Expect = 2.3 Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%) Query: 3370 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3427 SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C Sbjct: 289 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 346 Query: 3428 A 3428 A Sbjct: 347 A 347 Score = 33.1 bits (74), Expect = 5.2 Identities = 16/38 (42%), Positives = 19/38 (50%), Gaps = 1/38 (2%) Query: 2683 FSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCG 2720 F CD GY G ++ CL SW E P C + SCG Sbjct: 314 FHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MASCG 350 Score = 32.7 bits (73), Expect = 6.8 Identities = 20/73 (27%), Positives = 39/73 (53%), Gaps = 5/73 (6%) Query: 3573 MSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVHEN 3630 +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G + Sbjct: 830 VTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSP 886 Query: 3631 NNGQAAFENPMYD 3643 ++ F NP+Y+ Sbjct: 887 ITVESDFSNPLYE 899 >gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [Homo sapiens] Length = 853 Score = 224 bits (570), Expect = 2e-57 Identities = 181/670 (27%), Positives = 291/670 (43%), Gaps = 36/670 (5%) Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2127 C +S+ G + SP +L DCT++I++ G+G+ +Q + + L + Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 2128 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185 G S ++ S L S T+ L+F S GF I YQAY L Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 222 Query: 2186 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2245 PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG Sbjct: 223 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 281 Query: 2246 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2304 I A G I SP C W++ G ++++F + + D + V G Sbjct: 282 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 341 Query: 2305 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2362 SP I + E + S + + ++ S+ + + L + A++ C P + Sbjct: 342 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 400 Query: 2363 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2418 + + T D E+ G + + CLPG+ L NAI C + P C+ +C Sbjct: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 458 Query: 2419 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2478 EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG Sbjct: 459 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 516 Query: 2479 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2534 + VL L G + S+G ++ LQ+ A G G ++ + P + Sbjct: 517 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575 Query: 2535 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2589 PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ Sbjct: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 631 Query: 2590 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2646 I +C P NG +D + VG+ V Y C GY L + T + GT ++ Sbjct: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691 Query: 2647 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS 2706 P+C + P +N + E+G ++ + HY+ + F C G+ +G +I C+P Sbjct: 692 PKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ 750 Query: 2707 WRNERPYCQI 2716 W ++ P C++ Sbjct: 751 WTSQPPLCKV 760 Score = 208 bits (529), Expect = 9e-53 Identities = 189/718 (26%), Positives = 286/718 (39%), Gaps = 79/718 (11%) Query: 1894 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1950 T V C +++ +G + SP P L +C + I V G GI++QV + Sbjct: 98 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 157 Query: 1951 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2008 + L GG APRL + S +L S +N L L+FQS GF + Y A Sbjct: 158 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217 Query: 2009 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067 L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C Sbjct: 218 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275 Query: 2068 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2126 +A CGG + + + G I+SP G +L C W I G +HL F S + +D L Sbjct: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335 Query: 2127 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185 VRSG S S VI +P L S + S+ N + ++A++ C Sbjct: 336 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 395 Query: 2186 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2240 P +G V D + G +F C PGY L +A+ C+ +WN P C+ Sbjct: 396 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454 Query: 2241 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300 A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++ Sbjct: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 513 Query: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2354 DG ++ + Q G + S+ + ++F + GF + + Sbjct: 514 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 573 Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414 C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ Sbjct: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 630 Query: 2415 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2474 + CA + G+ ++ F V Sbjct: 631 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 655 Query: 2475 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2531 G ++Q Y + G + +S D G K R+ A C Sbjct: 656 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 703 Query: 2532 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 P P +GY + + Q +R+ C GF L+G+ + C W + P C+ Sbjct: 704 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCK 759 Score = 207 bits (528), Expect = 1e-52 Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%) Query: 855 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 911 C + S G + SP +L +C + I PG+ I+I + ++L + Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 912 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 969 G P L LL + + Q L S +N + L F + GF+IHY++ + S Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 219 Query: 970 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 1027 C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C Sbjct: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 279 Query: 1028 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1086 GG + + G I+SP +L C W ++ G+ + +F L++ +D L++ Sbjct: 280 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 339 Query: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1145 GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P Sbjct: 340 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 397 Query: 1146 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1201 + + + G TFSC GY LE + I C+ W+ P C A C Sbjct: 398 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 457 Query: 1202 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1261 G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG Sbjct: 458 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 517 Query: 1262 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1316 + +L G R LSS L L+F + G +GF L + + C + Sbjct: 518 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 576 Query: 1317 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1373 P++G++ + G G+ + Y C PGY L GS +L C +W P+C I Sbjct: 577 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 634 Query: 1374 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1432 C + + R S G+P RC+ PG SL+ A T S D Sbjct: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 682 Query: 1433 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1492 P +D + K A+++ C +PG Sbjct: 683 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 705 Query: 1493 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544 VP NG T + G+++ F C G+EL GE ITC+ W PP+C Sbjct: 706 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 758 Score = 206 bits (524), Expect = 3e-52 Identities = 190/786 (24%), Positives = 317/786 (40%), Gaps = 93/786 (11%) Query: 1381 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1437 E G + SP P L C + I V PG + +Q + ++L + G Sbjct: 109 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 168 Query: 1438 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495 + S++ EG + S N + + F + GF I + + + + C P P Sbjct: 169 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 227 Query: 1496 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1555 +G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + + Sbjct: 228 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 286 Query: 1556 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1614 + G I+SP + C W I + L F S++ + D L + G SP+ Sbjct: 287 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 346 Query: 1615 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1669 I +PER + S + ++++ S+ + L ++A + CF P GN+ Sbjct: 347 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 404 Query: 1670 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1726 T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG Sbjct: 405 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 461 Query: 1727 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1786 + G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG + Sbjct: 462 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 521 Query: 1787 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1842 +L+ L G L LSSG +T++F + P +GF ++ VPR + C +P Sbjct: 522 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 578 Query: 1843 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1900 P +G R + + G+ + + C PGY L GS + C QW+ S C Sbjct: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 630 Query: 1901 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1959 I+T ++ G+ D P G+ +Q + + ++ E Sbjct: 631 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 670 Query: 1960 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 2019 A L YS D + A+ + C P P Sbjct: 671 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 708 Query: 2020 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSD 2077 +G + Y G+ + F C +G+ L G ITC+PG +W P+C + + Sbjct: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDN 768 Query: 2078 FSGVILSPGFPGNYPSSLDCTWTINLPIGF------GVHLQFVNFSTETIHDYLEVRSGS 2131 + P + I LP+G GV++ + +++ + SGS Sbjct: 769 RKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGS 824 Query: 2132 SETSTV 2137 S + Sbjct: 825 HSYSPI 830 Score = 182 bits (463), Expect = 4e-45 Identities = 155/571 (27%), Positives = 239/571 (41%), Gaps = 31/571 (5%) Query: 1201 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1257 C + + EG + SP+ +C YSI V G GI I +T +L+Q + L + Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 1258 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1315 G +SM G L S +N+L L F S GF++ Y ++ LS C Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221 Query: 1316 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1375 P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG Sbjct: 222 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280 Query: 1376 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1435 G + GRI+SP NL C W+IE G + L F + +D L V G Sbjct: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340 Query: 1436 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1494 ++ + +PE G+ S + ++ ++ + +++F + C P + Sbjct: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400 Query: 1495 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1550 N T PG F C PGY L+ I C+ + W + P C A CGG Sbjct: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 459 Query: 1551 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1610 L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG Sbjct: 460 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 518 Query: 1611 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1663 ++ ++ + + R+ SS + L F++ GF L +K R ++C Sbjct: 519 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 578 Query: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH---- 1719 P T D G+ +TY C+ GY L G LTC W+ A P+C Sbjct: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 634 Query: 1720 -APCGSRSTGSEGTVLSPNYPKNYSVGHNCV 1749 A G + G T +P V + C+ Sbjct: 635 CADPGEIANGHR-TASDAGFPVGSHVQYRCL 664 Score = 170 bits (431), Expect = 2e-41 Identities = 192/786 (24%), Positives = 300/786 (38%), Gaps = 104/786 (13%) Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604 C N++ G++ SP+ P + DC ++I V Y I + + ++ + L + Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 1605 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1656 G +NS ++G Q + P +N + L F+S GF + Y+A Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 216 Query: 1657 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P Sbjct: 217 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 273 Query: 1717 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1772 SC A CG + G ++SP +VG N + F + SL + Sbjct: 274 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 331 Query: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832 D + V G + S ++ E +S + + S P ++A Sbjct: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 389 Query: 1833 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1887 +C + P G E+ G+ F C PGY L AI C V + Sbjct: 390 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 445 Query: 1888 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1947 WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV Sbjct: 446 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 504 Query: 1948 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 2003 D L +DG +A L G L S+ +L L FQ+ GF L Sbjct: 505 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 564 Query: 2004 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060 + + D+CPE P G + + G V+++QC+ GY L G +TC W Sbjct: 565 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 622 Query: 2061 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2120 + P C I++ PG + P+G H+Q+ + Sbjct: 623 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 668 Query: 2121 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2180 + + S +T T K + A + Sbjct: 669 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 697 Query: 2181 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238 + C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P Sbjct: 698 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757 Query: 2239 C-----EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL---VRVPPGNGIYINFTVLQT 2290 C E L + T P E N L + + G+G+YI +T LQ Sbjct: 758 CKVAYEELLDNRKLEVTQTT--DPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQG 815 Query: 2291 EPIYDF 2296 + ++ F Sbjct: 816 KSLFGF 821 Score = 167 bits (422), Expect = 2e-40 Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%) Query: 508 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 C +N+ G SP+ C + I V I+I + +L + L Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 161 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624 + GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC Sbjct: 162 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 220 Query: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 682 G P P +G F C G++L GE++++C + W+ P C+ C Sbjct: 221 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280 Query: 683 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 741 A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G Sbjct: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340 Query: 742 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 800 SP SP++ +VP L S++ L +E ++ + ++ + F + C P + Sbjct: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400 Query: 801 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 858 N ++ G+ + C G+ ++ G + + W+ P C A CGG Sbjct: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 460 Query: 859 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 918 S P+GV+LSP WP Y +C W + + I + E D+L + DG Sbjct: 461 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 519 Query: 919 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 974 + +L G Q + L SS + L F N GF +H++ V N +C + Sbjct: 520 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 578 Query: 975 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 1028 P G R D G+ +++ C+ GY L + L C+ + WS P C + C Sbjct: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 638 Query: 1029 GDVRGPSGTILSPGYP 1044 G++ T G+P Sbjct: 639 GEIANGHRTASDAGFP 654 Score = 122 bits (307), Expect = 5e-27 Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C P P +G +D G T F CD Y LQG +++ C + +W+ P C + Sbjct: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 276 Query: 506 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 +CG + + G SP N C WVI A + + ++FE L+ D L Sbjct: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 335 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 620 + GG P V+ S + D+ ++S + +++ L ++ + + ++ E Sbjct: 336 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 390 Query: 621 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 674 ++ C P + D + + F C G+ L +I C + + W+ Sbjct: 391 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 450 Query: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 734 P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D Sbjct: 451 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 509 Query: 735 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 790 L + DGD P + +L G + L S+ L L+FQA + G+GF + + Sbjct: 510 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 569 Query: 791 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 847 N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS Sbjct: 570 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 625 Query: 848 IPKC 851 P C Sbjct: 626 PPAC 629 Score = 94.7 bits (234), Expect = 1e-18 Identities = 60/170 (35%), Positives = 83/170 (48%), Gaps = 15/170 (8%) Query: 3148 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV-TCPTPPQISNGRLEG 3206 D + G ++Y C+PGY EL GS I TC + +WS P C+ + TC P +I+NG Sbjct: 591 DLIRGTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA 648 Query: 3207 TN--FDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKF--CGDPGIPA 3258 ++ F G + Y C PGY L A+LTC G WS VP+C K+ C +PG+P Sbjct: 649 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 708 Query: 3259 QGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQA--DGTWSGSSPHC 3304 G + YQ+ + F C F L+G T C W+ P C Sbjct: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758 Score = 88.2 bits (217), Expect = 1e-16 Identities = 61/189 (32%), Positives = 87/189 (46%), Gaps = 16/189 (8%) Query: 3015 TCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC-KA 3071 TC + P G R S+ + + Y C+ GY L GS+ TC + SW+ P C K Sbjct: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632 Query: 3072 VQCGNPGTTANGKVFRID-GTTFSSSVIYSCMEGYILSGPSVRQCTANGT----WSGTLP 3126 + C +PG ANG D G S V Y C+ GY L G ++ C + T WS +P Sbjct: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692 Query: 3127 NCTI--ISCGDPGIPANGLR--YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN--GT 3180 C + C +PG+P NG + Y Y G+++ + C G+ EL G TC Sbjct: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF--ELIGEVTITCVPGHPSQ 750 Query: 3181 WSGVMPTCR 3189 W+ P C+ Sbjct: 751 WTSQPPLCK 759 Score = 84.0 bits (206), Expect = 3e-15 Identities = 59/190 (31%), Positives = 81/190 (42%), Gaps = 12/190 (6%) Query: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951 N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C Sbjct: 571 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 630 Query: 2952 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3004 I C PG N S + GS V Y C SL G + TC WS Sbjct: 631 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 690 Query: 3005 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3060 P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+ Sbjct: 691 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 749 Query: 3061 SWTGRQPECK 3070 WT + P CK Sbjct: 750 QWTSQPPLCK 759 Score = 83.2 bits (204), Expect = 4e-15 Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%) Query: 3192 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248 TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C Sbjct: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632 Query: 3249 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3302 C DPG A G R F S V + C + L G++ C + T WS P Sbjct: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692 Query: 3303 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3359 C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W Sbjct: 693 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751 Query: 3360 SGIQPEC 3366 + P C Sbjct: 752 TSQPPLC 758 Score = 82.4 bits (202), Expect = 7e-15 Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%) Query: 2796 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2851 R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF Sbjct: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 653 Query: 2852 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2905 V + C GY ++G C + +WS P C K C +PG+P N + Sbjct: 654 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 713 Query: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2950 H + G + + C G+ L G + C P QW P C Sbjct: 714 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758 Score = 69.7 bits (169), Expect = 5e-11 Identities = 76/278 (27%), Positives = 113/278 (40%), Gaps = 16/278 (5%) Query: 25 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81 C + G +ESP G P G +CT+ I I+I Q+ L +E + L L Sbjct: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162 Query: 82 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 G R L + S + L S GF+++Y+ S CG Sbjct: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 P P G + T G + C +GY L G L C+ + SW+ P C A Sbjct: 222 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 277 Query: 200 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 257 +CGGT+ ++ G I SP N C W I A G + L F ++E D L + Sbjct: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337 Query: 258 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 291 G P P I+ S M+ P +IS+ L + ++++ Sbjct: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 375 Score = 68.2 bits (165), Expect = 1e-10 Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 12/259 (4%) Query: 24 TCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82 +CGGT+ G I SP C WVI A E R+ + F+ +L+E+ D L + Sbjct: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337 Query: 83 DGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 G P + + + ++ +S++ + L S+ + + +E + C Sbjct: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRFEAFEEDRCFA 396 Query: 141 PGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTASWDFPVPICR 196 P + V + G +SC+ GY L+ G P + C+ W+ P C+ Sbjct: 397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACK 454 Query: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE 256 A CGG + +G++ SP +P Y DC W + + I L + E Sbjct: 455 A--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 512 Query: 257 IEGSEPPTIWLSGMNIPPP 275 +G P L+ + P P Sbjct: 513 FDGDGPSARVLAQLRGPQP 531 Score = 67.8 bits (164), Expect = 2e-10 Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 15/188 (7%) Query: 2718 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC-LA 2774 +C ELP P G + + G+ + C+ G+ L+GS + C WS + C Sbjct: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632 Query: 2775 GHCGIPELIVNGQVIGENYGY--RDTVVYQCNPGFRLIGSSVRICQQ----DHNWSGQLP 2828 C P I NG + G+ V Y+C PG+ L G+++ C WS ++P Sbjct: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692 Query: 2829 SCV--PVSCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2882 C C +PG P G + + + + + F C G+ + G C QW+ Sbjct: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 752 Query: 2883 HPPPMCKV 2890 PP+CKV Sbjct: 753 SQPPLCKV 760 Score = 57.0 bits (136), Expect = 3e-07 Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG Sbjct: 457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 515 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 139 +L G + S+ +L+ + GF ++++E+ ++ +C Sbjct: 516 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575 Query: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 P G + D+ G + Y C GY L G LTC + SW P C+ Sbjct: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 631 Query: 198 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 227 C G + S FP H C Sbjct: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 663 Score = 53.5 bits (127), Expect = 4e-06 Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%) Query: 2956 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 3015 G PG+ P + + G + S T + L QS R + G Q + + Sbjct: 166 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 219 Query: 3016 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 3072 CG P P HG ++ T + CD+GY L G E CL NG SW G P C A Sbjct: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 277 Query: 3073 QCGNPGTTANGKVFRI 3088 CG GT N + RI Sbjct: 278 SCG--GTIHNATLGRI 291 Score = 52.8 bits (125), Expect = 6e-06 Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%) Query: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C Sbjct: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694 Query: 504 KVK 506 +K Sbjct: 695 ALK 697 Score = 52.0 bits (123), Expect = 1e-05 Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%) Query: 3307 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3365 P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P Sbjct: 569 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 628 Query: 3366 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3418 C +C P A+ A+ G + SH + Y C PG+ L G C S +T Sbjct: 629 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 684 Query: 3419 --WTGKVPIC 3426 W+ +VP C Sbjct: 685 PKWSDRVPKC 694 Score = 44.3 bits (103), Expect = 0.002 Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%) Query: 137 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 +C +PG G F VG ++Y C+ GY L+G LTC + T W VP Sbjct: 634 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 693 Query: 195 C 195 C Sbjct: 694 C 694 Score = 44.3 bits (103), Expect = 0.002 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%) Query: 133 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W Sbjct: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 753 Query: 191 PVPICR 196 P+C+ Sbjct: 754 QPPLCK 759 Score = 43.9 bits (102), Expect = 0.003 Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 14/148 (9%) Query: 1659 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P Sbjct: 699 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 756 Query: 1717 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1776 C + V P G N +I +P V+ L V Sbjct: 757 LCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 807 Query: 1777 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1804 +Y Q SL SGSHS + + S Sbjct: 808 IYYTKLQGKSLF-GFSGSHSYSPITVES 834 Score = 42.0 bits (97), Expect = 0.011 Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%) Query: 3191 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3247 ++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+ Sbjct: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 276 Query: 3248 PKFCG 3252 CG Sbjct: 277 AS-CG 280 Score = 41.2 bits (95), Expect = 0.019 Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%) Query: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773 ++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+ Sbjct: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276 Query: 2774 AGHCGIPELIVNGQVIGENYG 2794 A G G+++ G Sbjct: 277 ASCGGTIHNATLGRIVSPEPG 297 Score = 41.2 bits (95), Expect = 0.019 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%) Query: 619 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 674 ++ E C +PG P G + + + LRF C GFELIGE +I C +QW++ Sbjct: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 755 Query: 675 PIC 677 P+C Sbjct: 756 PLC 758 Score = 40.4 bits (93), Expect = 0.033 Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%) Query: 3311 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3367 SC P P HG + T G FHC G+ LQG T CL +W+G P C+ Sbjct: 219 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276 Score = 38.5 bits (88), Expect = 0.12 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%) Query: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3186 ++SCG P PA+G D G ++ C GY +L G C +NGT W+G P Sbjct: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 273 Query: 3187 TCRAVTCPTPPQISNGRL 3204 +C A T + GR+ Sbjct: 274 SCMASCGGTIHNATLGRI 291 Score = 38.5 bits (88), Expect = 0.12 Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%) Query: 2777 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH--NWSGQLPSCVPVS 2834 CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S Sbjct: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 278 Query: 2835 CG 2836 CG Sbjct: 279 CG 280 Score = 38.5 bits (88), Expect = 0.12 Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%) Query: 446 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C Sbjct: 701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 758 Query: 504 KV 505 KV Sbjct: 759 KV 760 Score = 35.8 bits (81), Expect = 0.80 Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%) Query: 2833 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2888 +SCG P P +G S + TF C+ GY +QG C W+ P C Sbjct: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275 Score = 35.0 bits (79), Expect = 1.4 Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%) Query: 2949 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 3005 + ++ CG P P + +S G T + C L G+ + C LNG W+G Sbjct: 214 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 272 Query: 3006 PHCSGDATGT 3015 P C GT Sbjct: 273 PSCMASCGGT 282 Score = 34.3 bits (77), Expect = 2.3 Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%) Query: 3370 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3427 SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C Sbjct: 219 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 276 Query: 3428 A 3428 A Sbjct: 277 A 277 Score = 34.3 bits (77), Expect = 2.3 Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Query: 3571 LNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVH 3628 L +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G + Sbjct: 771 LEVTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSY 827 Query: 3629 ENNNGQAAFENPMYD 3643 ++ F NP+Y+ Sbjct: 828 SPITVESDFSNPLYE 842 Score = 33.1 bits (74), Expect = 5.2 Identities = 16/38 (42%), Positives = 19/38 (50%), Gaps = 1/38 (2%) Query: 2683 FSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCG 2720 F CD GY G ++ CL SW E P C + SCG Sbjct: 244 FHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MASCG 280 >gi|22547221 tolloid-like 1 [Homo sapiens] Length = 1013 Score = 218 bits (555), Expect = 9e-56 Identities = 201/831 (24%), Positives = 329/831 (39%), Gaps = 191/831 (22%) Query: 500 RPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-- 557 R + + CG LQ +G +SP FP Y S C+W ++ K++ +NF DL Sbjct: 341 RKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIV-LNFTTMDLYKS 399 Query: 558 --IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN 615 YD + + DG P +L G +P+++ S S+MW+ ++ + GF Sbjct: 400 SLCWYDYIEVRDGYWRKSP--LLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457 Query: 616 YKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP 675 Y+ I CG IR+ +G Sbjct: 458 YEAI----CGGE------IRKNEG------------------------------------ 471 Query: 676 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ---- 731 + SP+YP+ Y C+W I + L+F F++E Sbjct: 472 ---------------QIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCA 516 Query: 732 FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH 791 +D+L V+DG S SP++G F G + P + S S+ L ++F +D +++ GF + Sbjct: 517 YDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EE 575 Query: 792 NECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851 +EC P R G CE+ + T G+ C + C Sbjct: 576 DECAKPD------RGG------------CEQRCLNTLGSYQCAC---EPGYELGPDRRSC 614 Query: 852 GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YD 907 A CGG + +G I +PGWP Y + NC W + A + I + FE F+ E N YD Sbjct: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674 Query: 908 VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 967 +E+ G + S L G + G +VP+ + S N + + F +DN+ S GFK H+ Sbjct: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF------- 727 Query: 968 YSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALC 1027 +S D +G + + C +G+ L H+ C+ +A C Sbjct: 728 FSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVL-HDNKHDCK------------EAEC 774 Query: 1028 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLI 1083 + PSG I SP +P+ YP+ CTW + T G ++ F F +E H +D+L + Sbjct: 775 EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEV 834 Query: 1084 TENGSFTQP-LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1142 + + P L RL G+ +P + A GN + +RF+SD S+ +GF Sbjct: 835 FDGETEKSPILGRLCGNKIPDPLVA--TGN-KMFVRFVSDASVQRKGFQ----------- 880 Query: 1143 EDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECG 1202 T S G RL+ S+ PR + Sbjct: 881 ---------------------ATHSTECGGRLKAESK---------------PRDLYSHA 904 Query: 1203 ASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-----DVLKIY 1257 NN Y +C + + + G + +S +TF + + D ++++ Sbjct: 905 QFGDNN------------YPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELF 952 Query: 1258 DGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308 DG D T LG F G+ + S + + + F++D +GF + Y S Sbjct: 953 DGLDSTAVGLGRFCGSGPPE-EIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002 Score = 206 bits (523), Expect = 4e-52 Identities = 177/662 (26%), Positives = 279/662 (42%), Gaps = 144/662 (21%) Query: 1372 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1427 A CGG + ++ G+I SP YP Y C+W I V V L F +F+ E ++D Sbjct: 460 AICGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518 Query: 1428 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1487 L V DG EN L+ G PE I ST N + ++F +D ++K+GFA F Sbjct: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKE-EDE 577 Query: 1488 CRDPGVPMNGTRNGDGREPGDTV---VFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544 C P R G + +T+ C+PGYEL + R C Sbjct: 578 CAKPD------RGGCEQRCLNTLGSYQCACEPGYELGPDRRS-----------------C 614 Query: 1545 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YD 1600 A CGG LT +G I +P +P YP +++C W + Y IS+ F F +E N YD Sbjct: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674 Query: 1601 FLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRES 1660 ++ I+ G S S L G F +++PE I S N M + F+SD +VS GF + + E Sbjct: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734 Query: 1661 CFDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717 D G G ++ +T+ Y C G+VL + Sbjct: 735 SKDNG--------GCQHECVNTMGSYMCQCRNGFVLH-----------------DNKHDC 769 Query: 1718 CHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSI-AVPKEFV--VFGQFVF--FQTSLH 1772 A C + G + SPN+P Y C + I A P + F +F Q + Sbjct: 770 KEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAY 829 Query: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832 D +EV+DG T++S +L L G+ + L +++GN++ +RF S + KGF Sbjct: 830 DHLEVFDGETEKSPILGRLCGNKIPDPL-VATGNKMFVRFVSDASVQRKGFQ-------A 881 Query: 1833 TSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL---AQWN 1889 T ST+C GR ++ E+ P L AQ+ Sbjct: 882 THSTECG-------GR---------------------------LKAESKPRDLYSHAQFG 907 Query: 1890 DSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH- 1948 D+ Y ++C W + G+ +++ +F E Sbjct: 908 DN--------------------------NYPGQVDCEWLLVSERGSRLELSFQTFEVEEE 941 Query: 1949 ---NWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYT 2005 +D ++ +DG D+ A LG + G+ P + S +++ ++F +D +++ GFH+ Y Sbjct: 942 ADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001 Query: 2006 AI 2007 +I Sbjct: 1002 SI 1003 Score = 197 bits (500), Expect = 2e-49 Identities = 154/510 (30%), Positives = 227/510 (44%), Gaps = 76/510 (14%) Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1601 A CGG + + G I SPN+P Y ++C W ITV+ Y + L F SF IE + YD+ Sbjct: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519 Query: 1602 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1661 L + DG NSPLIG F PE I S+SNT+ + F SDG+V+ GF + K + C Sbjct: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF-FKEEDEC 578 Query: 1662 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 P R G + + +T+ Y C+ GY L G D R SC Sbjct: 579 AKP------DRGGCEQRCLNTLGSYQCACEPGYEL----------GPDRR--------SC 614 Query: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFF-----QTSLHD 1773 A CG T GT+ +P +PK Y NCV+ + P ++ + +F FF + +D Sbjct: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674 Query: 1774 VVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1831 VE++ G + +S L G+ E + S N + I F S ++ KGF HF Sbjct: 675 YVEIWSGLSSESKLHGKFCGAEVPEVI-TSQFNNMRIEFKSDNTVSKKGFKAHFF----- 728 Query: 1832 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDS 1891 + +CS + G + +G S + C G++LH D+ Sbjct: 729 -SDKDECS---KDNGGCQHECVNTMG-SYMCQCRNGFVLH------------------DN 765 Query: 1892 LPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN- 1949 C C + G I SP +P+ Y + C W+I+ G I++ F E + Sbjct: 766 KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQ 825 Query: 1950 ---WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY-T 2005 +D L+ +DG +P LG G IP L +T N +++ F SD SV GF + T Sbjct: 826 ECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885 Query: 2006 AIG--LDSCPEPQTPSSGIKIGDRYMVGDV 2033 G L + +P+ S + GD G V Sbjct: 886 ECGGRLKAESKPRDLYSHAQFGDNNYPGQV 915 Score = 183 bits (464), Expect = 3e-45 Identities = 141/501 (28%), Positives = 219/501 (43%), Gaps = 62/501 (12%) Query: 1720 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1774 A CG +EG + SPNYP +Y CV+ I V + + V F F+ HD Sbjct: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519 Query: 1775 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1834 +EV DG ++ S L+ G E + S+ N + ++F S G + GF + Sbjct: 520 LEVRDGTSENSPLIGRFCGYDKPEDIR-STSNTLWMKFVSDGTVNKAGFAANFFK----E 574 Query: 1835 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894 +C+ +R N S C PGY L + Sbjct: 575 EDECAKPDRGGCEQRCLNTLG---SYQCACEPGYEL------------------GPDRRS 613 Query: 1895 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1950 C CGG+LTK GTI +PG+P+ Y N NCVW++ P I V+ F E N + Sbjct: 614 CEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKY 673 Query: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010 D ++ + G + + G + G +P ++ S NN+ + F+SD +VS GF + + D Sbjct: 674 DYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKD 732 Query: 2011 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2070 C + + G + +G + QC G+ L + H C A+ Sbjct: 733 ECSK---DNGGCQHECVNTMGSYMC-QCRNGFVLHDNKH-DCKE--------------AE 773 Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS----TETIHDYLE 2126 C + SG+I SP +P YPS +CTW I+ G + L F F E +D+LE Sbjct: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833 Query: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAY---QLQS 2183 V G +E S ++GRL G +IP L +T ++ + F SD S ++GF + +L++ Sbjct: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKA 893 Query: 2184 CPDPRPFRNGFVIGNDFTVGQ 2204 PR + G++ GQ Sbjct: 894 ESKPRDLYSHAQFGDNNYPGQ 914 Score = 181 bits (458), Expect = 2e-44 Identities = 142/469 (30%), Positives = 217/469 (46%), Gaps = 64/469 (13%) Query: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124 A CGG + G I SP +P +Y +C W I + + V L F +F E +DY Sbjct: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519 Query: 2125 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2184 LEVR G+SE S +IGR G P + ST++ + F SD + NK GF + + + Sbjct: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECA 579 Query: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244 +P R G T+G + C PGY L G R CEA CG Sbjct: 580 ---KPDRGGCEQRCLNTLG-SYQCACEPGYEL----------GPDRR------SCEAACG 619 Query: 2245 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2300 G +T +NGTI +PG+P EYP ++C W V P I + F + E YD++ +W Sbjct: 620 GLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIW 679 Query: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFVLSYHAYQLRVCQPP 2358 G S G+F G E + S N + I+F SD T S GF Sbjct: 680 SGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGF---------------- 723 Query: 2359 PPVPNAEILTEDDE-FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCP 2417 A ++ DE + +++C+ +G+ + CR G L D + C Sbjct: 724 ----KAHFFSDKDECSKDNGGCQHECV---NTMGSYMCQCRNGFVLH-DNKHDCKEAEC- 774 Query: 2418 ANELRLDS-TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVL 2472 E ++ S +G+I SP +PD YP+ + C W IS G+ I + F+ E+ +D L Sbjct: 775 --EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832 Query: 2473 QVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR 2521 +V+DG +SP+L L G+ + + G+++F+++ +D +KGF+ Sbjct: 833 EVFDGETEKSPILGRLCGN-KIPDPLVATGNKMFVRFVSDASVQRKGFQ 880 Score = 150 bits (379), Expect = 2e-35 Identities = 130/501 (25%), Positives = 207/501 (41%), Gaps = 63/501 (12%) Query: 1024 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1079 +A+CGG++R G I SP YP+ Y C W + V+ V F +F +E H +D Sbjct: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518 Query: 1080 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138 YL + + S PL R G D P I + + ++F+SD +++ GF F + Sbjct: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRS---TSNTLWMKFVSDGTVNKAGFAANFFKEE 575 Query: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 + C P R G + +C GY LG RR C Sbjct: 576 -DECAKPDRGGCEQRCLNTLG---SYQCACEPGYE---------LGPDRR-------SCE 615 Query: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1255 A CG T G + +P +P Y N C++ + I++ F L +V K Sbjct: 616 AACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDY 675 Query: 1256 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313 I+ G + L G F GA + + ++S N + +EF SD + +GF+ + S + Sbjct: 676 VEIWSGLSSESKLHGKFCGAEVPEV-ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734 Query: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1373 +D G Q ++ G + + C G+ LH D AE Sbjct: 735 SKDNGGCQHEC-VNTMGSY-----MCQCRNGFVLH---------------DNKHDCKEAE 773 Query: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFD----TEASHDIL 1429 C + SG I SP +P Y + C W I PG+ + L F F+ E ++D L Sbjct: 774 CEQKIH-SPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832 Query: 1430 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1489 V+DG E +L + G+ IP+ + +T N + ++F +D + + GF S+ + Sbjct: 833 EVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLK 892 Query: 1490 DPGVP---MNGTRNGDGREPG 1507 P + + GD PG Sbjct: 893 AESKPRDLYSHAQFGDNNYPG 913 Score = 141 bits (355), Expect = 1e-32 Identities = 121/472 (25%), Positives = 200/472 (42%), Gaps = 102/472 (21%) Query: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 563 CG L +GT T+P +P +Y N CVW + A T I + FE F+LE YD + Sbjct: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAP-TQYRISVKFEFFELEGNEVCKYDYV 676 Query: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623 I G + + G+ VP++I S + M + ++D +V GFK ++ +K+ Sbjct: 677 EIWSG--LSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKDE 733 Query: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683 C G + + + +C+ GF L K C+E C Sbjct: 734 CSKDN----GGCQHECVNTMGSYMCQCRNGFVLHDNKHD-CKEAE------------CEQ 776 Query: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKD 739 +P G + SP++P+ Y + C W I + PG RI L+F++F++E +D L V D Sbjct: 777 KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836 Query: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGI 799 G++ +SPILG G N+ PDP + Sbjct: 837 GETEKSPILGRLCG--------------------------------------NKIPDPLV 858 Query: 800 PINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHF 859 + F F +S+ +GF T TE CGG Sbjct: 859 ATGNKMFV-RFVSDASVQ---RKGFQATHSTE-----------------------CGGRL 891 Query: 860 SAPSGV--ILSPGWPG--YYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEV 911 A S + S G Y ++CEW++ +E G ++++F+ F+ E YD +E+ Sbjct: 892 KAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEL 951 Query: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV 963 DG + + LG + G+ P+ ++S + + + F TD++ + GF I Y+S+ Sbjct: 952 FDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003 Score = 135 bits (340), Expect = 7e-31 Identities = 90/304 (29%), Positives = 145/304 (47%), Gaps = 46/304 (15%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 80 CGG L LNGTI +PG+P YP NC W ++A + RI + F+ F LE +YDY+ Sbjct: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139 ++ G + + G +P +TS + + SD VS GFK ++ + S Sbjct: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKD 737 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 N G + V + C G++L + C+ E Sbjct: 738 NGGCQHECV------NTMGSYMCQCRNGFVLHDNKH------------------DCK-EA 772 Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 255 C + SG+I+SP++P++Y + +CTW I A PG I L F++F++E+ YD+L Sbjct: 773 ECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832 Query: 256 EI---EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311 E+ E + P + L G IP P+++ N + + FV+D++ + +GF A TH+ Sbjct: 833 EVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQA--------THS 884 Query: 312 TSTG 315 T G Sbjct: 885 TECG 888 Score = 115 bits (287), Expect = 1e-24 Identities = 87/302 (28%), Positives = 137/302 (45%), Gaps = 46/302 (15%) Query: 2240 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2295 EA+CGG I G I SP YPD+Y ++C W + V + + F + E YD Sbjct: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518 Query: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTT--SGFFVLSYHAYQLR 2353 ++ V DG +NSP IG+F G E + STSN + +KF SD T +GF Sbjct: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGF----------- 567 Query: 2354 VCQPPPPVPNAEILTEDDEFEIGDI--IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV 2411 A E+DE D +CL +G+ C G L D Sbjct: 568 ---------AANFFKEEDECAKPDRGGCEQRCL---NTLGSYQCACEPGYELGPDRRS-- 613 Query: 2412 CQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK---- 2467 C+ C +L+ G I +PG+P YP + C W + Y I++ EFF+ E Sbjct: 614 CEAACGGLLTKLN--GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVC 671 Query: 2468 EFDVLQVYDGPNIQSPVLISLSGDYSSA---FNITSNGHEVFLQWSADHGNNKKGFRIRY 2524 ++D ++++ G + +S L G + A ITS + + +++ +D+ +KKGF+ + Sbjct: 672 KYDYVEIWSGLSSES----KLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF 727 Query: 2525 IA 2526 + Sbjct: 728 FS 729 Score = 112 bits (281), Expect = 5e-24 Identities = 82/290 (28%), Positives = 124/290 (42%), Gaps = 36/290 (12%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CGG ++ G I+SP +P Y C W I E + + FQSF +E YDYL Sbjct: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 + DG + R G+ P + ST + ++ SD V+ GF + + + C Sbjct: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EEDECAK 580 Query: 141 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 200 P +G + + +C GY L G + +C E A Sbjct: 581 PD---RGGCEQRCLNTLGSYQCACEPGYEL-GPDRRSC-------------------EAA 617 Query: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 256 CGG + +G I++P +P EY N +C W +VA IS+ F F++E KYDY+E Sbjct: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677 Query: 257 IEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 I L G +P I S N +R+ F +D+ +GF A + Sbjct: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF 727 Score = 100 bits (250), Expect = 2e-20 Identities = 78/299 (26%), Positives = 132/299 (44%), Gaps = 68/299 (22%) Query: 498 DHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDL- 556 D++ CK C + PSG TSPN+P +Y S +C W I+A ++ I++ F EF++ Sbjct: 764 DNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHR-IKLAFSEFEIE 822 Query: 557 ---EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFK 613 E YD L + DG P +L L G+ +PD +V+ ++M++ +D SV GF+ Sbjct: 823 QHQECAYDHLEVFDGETEKSP--ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQ 880 Query: 614 VNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 673 + CG G + D +S+ QFG +NN Sbjct: 881 ATH----STECG--GRLKAESKPRDLYSH-------AQFG------------DNN----- 910 Query: 674 IPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ-- 731 Y ++C W ++S+ GSR+ LSF F++E + Sbjct: 911 ---------------------------YPGQVDCEWLLVSERGSRLELSFQTFEVEEEAD 943 Query: 732 --FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 788 +D++ + DG + LG F G+ P + S + + F D +++ +GF+I Y + Sbjct: 944 CGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002 Score = 77.0 bits (188), Expect = 3e-13 Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 5/104 (4%) Query: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2293 L RC A CG + NG + SPG+P+ YP++ C W V V PG I +NFT + Sbjct: 343 LYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSL 401 Query: 2294 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHS 2335 YD+I V DG + SP +G+F G+ E + ST +++ I+F S Sbjct: 402 CWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRS 445 Score = 70.1 bits (170), Expect = 4e-11 Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 4/112 (3%) Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2126 CG + + +G + SPGFP YPS C W +++ G + L F S+ +DY+E Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408 Query: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 VR G S ++GR G ++P L ST + F S + +GF VY+A Sbjct: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460 Score = 68.6 bits (166), Expect = 1e-10 Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 4/112 (3%) Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603 CG L S+G + SP FP+ YP C W ++V I L F + + + YD++ Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1655 + DG SPL+G F KLPE + S+ + M + FRS + GF Y+A Sbjct: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460 Score = 67.4 bits (163), Expect = 2e-10 Identities = 77/318 (24%), Positives = 109/318 (34%), Gaps = 71/318 (22%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CG TL+ NG + SPGFP GYP+ +C W + +I + F + L + YDY+ Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 + DG+ + R G LP +TST S + S GF YE + CG Sbjct: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI----CGG 464 Query: 141 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 200 +G + Y D P C+ W V +E Sbjct: 465 EIRKNEGQIQS--------------PNYPDDYRPMKECV--------WKITV----SESY 498 Query: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG- 259 G ++ SF E H+N YDYLE+ Sbjct: 499 HVG--------LTFQSFEIERHDNC-------------------------AYDYLEVRDG 525 Query: 260 ---SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGE 316 + P G + P I S N L + FV+D GF+A + G Sbjct: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585 Query: 317 LEEHNRTTTGAIAVASTP 334 E+ T G+ A P Sbjct: 586 CEQRCLNTLGSYQCACEP 603 Score = 65.5 bits (158), Expect = 9e-10 Identities = 39/131 (29%), Positives = 68/131 (51%), Gaps = 5/131 (3%) Query: 837 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 896 L G + + + +C A CG +G + SPG+P Y +C W + PG I + Sbjct: 332 LSKGDIAQARKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLN 390 Query: 897 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 952 F + +++ L YD +EV DG SPLLG + G ++P+ L S+ + +++ F + ++ Sbjct: 391 FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV 450 Query: 953 NNGFKIHYESV 963 GF YE++ Sbjct: 451 GKGFAAVYEAI 461 Score = 64.7 bits (156), Expect = 2e-09 Identities = 35/116 (30%), Positives = 59/116 (50%), Gaps = 10/116 (8%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN-------WD 1951 CG L + G + SPG+P Y + +C+W+++V G I V++F T +D Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKI---VLNFTTMDLYKSSLCWYD 405 Query: 1952 SLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2007 ++ DG +P LG + G +P +L ST + +++ F+S + GF Y AI Sbjct: 406 YIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461 Score = 63.5 bits (153), Expect = 4e-09 Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%) Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255 ACG T++ S+G +SSP FPN Y + C W + PG+ I L FT + + YDY+ Sbjct: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407 Query: 256 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311 E+ P G +P + S + + + F + SN +GF+A Y+ Sbjct: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIR 467 Query: 312 TSTGELEEHN 321 + G+++ N Sbjct: 468 KNEGQIQSPN 477 Score = 62.8 bits (151), Expect = 6e-09 Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 4/93 (4%) Query: 2090 NYPSSLDCTWTINLPIGFGVHLQFVNFSTETI----HDYLEVRSGSSETSTVIGRLSGPQ 2145 NYP +DC W + G + L F F E +DY+E+ G T+ +GR G Sbjct: 910 NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSG 969 Query: 2146 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 P ++S ++FH+D + NK+GFHI Y++ Sbjct: 970 PPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002 Score = 57.0 bits (136), Expect = 3e-07 Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 9/122 (7%) Query: 1365 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1424 Y P+C G ES+G + SPG+P Y + C+W + V PG + L F D Sbjct: 344 YRCPAC-----GETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYK 398 Query: 1425 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1480 S +D + V DG LL G +PE + ST + + I+F + GFA + Sbjct: 399 SSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458 Query: 1481 SS 1482 + Sbjct: 459 EA 460 Score = 57.0 bits (136), Expect = 3e-07 Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 10/112 (8%) Query: 2243 CGGNITAMNGT--IYSPGY--PDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----Y 2294 CGG + A + +YS + YP DC WL+ G+ + ++F + E Y Sbjct: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946 Query: 2295 DFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFV 2344 D++ ++DG D + +G+F G+ E +YS + +LI FH+D T + GF + Sbjct: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHI 998 Score = 53.9 bits (128), Expect = 3e-06 Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 12/115 (10%) Query: 201 CGGTMRGSS---GIISSPSF-PNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----Y 252 CGG ++ S + S F N Y DC W +V+E G + L F F++EE+ Y Sbjct: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946 Query: 253 DYLEI-EGSEPPTIWLS---GMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 DY+E+ +G + + L G P I S + + +HF TD +GF Y+ Sbjct: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001 Score = 53.9 bits (128), Expect = 3e-06 Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 4/94 (4%) Query: 45 YPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLSLYDGHPHPTNFRTRLTGFHL 100 YP +C W++++E +R+++ FQ+F +EEE YDY+ L+DG R G Sbjct: 911 YPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGP 970 Query: 101 PPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQ 134 P + S + +D ++ GF + Y+ ++ Sbjct: 971 PEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIR 1004 Score = 53.1 bits (126), Expect = 5e-06 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%) Query: 1713 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1769 R L C A CG S G + SP +P Y +C++ ++V P E +V F +++ Sbjct: 341 RKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKS 399 Query: 1770 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827 SL +D +EV DG ++S LL G E L S+ +++ I F S KGF VY Sbjct: 400 SLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVL-TSTDSRMWIEFRSSSNWVGKGFAAVY 458 Query: 1828 QAV 1830 +A+ Sbjct: 459 EAI 461 Score = 50.4 bits (119), Expect = 3e-05 Identities = 35/116 (30%), Positives = 54/116 (46%), Gaps = 6/116 (5%) Query: 2416 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2470 CPA E +S G + SPG+P+ YP+ C W +SV G I + K +D Sbjct: 346 CPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405 Query: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526 ++V DG +SP+L GD +TS +++++ + KGF Y A Sbjct: 406 YIEVRDGYWRKSPLLGRFCGDKLPEV-LTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460 Score = 43.9 bits (102), Expect = 0.003 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 5/93 (5%) Query: 2436 DSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQSPVLISLSGD 2491 ++YP C W + E+G + + + F+ E+E +D ++++DG + + L G Sbjct: 909 NNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGS 968 Query: 2492 YSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2524 I S G V + + D NKKGF IRY Sbjct: 969 -GPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000 >gi|6912724 tolloid-like 2 [Homo sapiens] Length = 1015 Score = 213 bits (543), Expect = 2e-54 Identities = 179/657 (27%), Positives = 276/657 (42%), Gaps = 134/657 (20%) Query: 500 RPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDL--- 556 R + K CG LQ +G F++P FP Y S + CVW I+ K++ +NF DL Sbjct: 343 RKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIV-LNFTSMDLFKS 401 Query: 557 -EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN 615 YD + + DG P +L G +P+ +VS S++W+ ++ ++ GF Sbjct: 402 RLCWYDYVEVRDGYWRKAP--LLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAA 459 Query: 616 YKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP 675 Y + +CG G N+D Sbjct: 460 Y----EATCG-------------GDMNKDA------------------------------ 472 Query: 676 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ---- 731 G + SP+YP+ Y + C+W I G + L+F F++E Sbjct: 473 --------------GQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCA 518 Query: 732 FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH 791 +D+L V+DG + ES ++G F G E P + S+S+ L ++F +D S++ GF N F Sbjct: 519 YDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGF--AANFFKE 576 Query: 792 -NEC--PDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 848 +EC PD G CE + T G+ C D + Sbjct: 577 VDECSWPDHG--------------------GCEHRCVNTLGSYKCAC---DPGYELAADK 613 Query: 849 PKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN--- 905 C CGG + +G I SPGWP Y + NC W + A + I + FE F+ E N Sbjct: 614 KMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVC 673 Query: 906 -YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVT 964 YD +EV G + + L G + G++ P+ + S SN + + F +DN+ S GF+ H+ Sbjct: 674 KYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHF---- 729 Query: 965 VNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 1024 +S D +G + + C +GY L HE C+ + Sbjct: 730 ---FSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWL-HENGHDCK------------E 773 Query: 1025 ALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDY 1080 A C + GT+ SP +P+ YP+ CTW + T G V+ F+ F +E H +D+ Sbjct: 774 AGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDH 833 Query: 1081 LLITENGSFTQP-LARLTGSDLP-PTINAGLYGNFRAQLRFISDFSISYEGFNITFS 1135 L + + P L R GS P PT+ +G LRF SD S+ +GF S Sbjct: 834 LEMYDGPDSLAPILGRFCGSKKPDPTVASG----SSMFLRFYSDASVQRKGFQAVHS 886 Score = 207 bits (526), Expect = 2e-52 Identities = 172/648 (26%), Positives = 281/648 (43%), Gaps = 126/648 (19%) Query: 507 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 562 TCG ++ +G SPN+P Y + +CVW IT V+ + + F+ F++E YD Sbjct: 463 TCGGDMNKDAGQIQSPNYPDDYRPSKECVWRIT-VSEGFHVGLTFQAFEIERHDSCAYDY 521 Query: 563 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY-KEIEK 621 L + DG + ++ G P+ + S S+++W+ +D S+ GF N+ KE+++ Sbjct: 522 LEVRDGPT--EESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDE 579 Query: 622 ESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 681 S D G G +R V +G C + +A+ +C C Sbjct: 580 CSWPDHG----------GCEHRCV---------NTLGSYKCACDPGYELAADKKMCEVAC 620 Query: 682 LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAV 737 T GT+ SP +P+ Y N NC+W +++ RI L F F+LE ++DF+ V Sbjct: 621 GGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEV 680 Query: 738 KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDP 797 + G SP++ + G F G+E P +TS S+ +R+EF++D+++S RGF + + +EC Sbjct: 681 RSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFS-DKDEC--- 736 Query: 798 GIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGG 857 A+ G C+ + T G+ C +G + A C Sbjct: 737 -----AKDNGG-----------CQHECVNTFGSYLCRC--RNGYWLHENGHDCKEAGCAH 778 Query: 858 HFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEVHD 913 S+ G + SP WP Y C W I + GH +K+TF F+ E + YD LE++D Sbjct: 779 KISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYD 838 Query: 914 GPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDP 973 GP+ L+P+LG + G++ P +S + ++L F +D S GF+ Sbjct: 839 GPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQ---------------- 882 Query: 974 GIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRG 1033 VH S + G RL E + +SH GD Sbjct: 883 --AVH----------------STECGGRLKAE----VQTKELYSHAQ-------FGDNNY 913 Query: 1034 PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITENGSF 1089 PS C W + G GV+ F TF +E+ +DY+ + Sbjct: 914 PS--------------EARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDS 959 Query: 1090 TQP-LARLTGS-DLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFS 1135 + P L R GS L +AG +RF +D +I+ +GF+ ++ Sbjct: 960 SAPRLGRFCGSGPLEEIYSAG----DSLMIRFRTDDTINKKGFHARYT 1003 Score = 194 bits (494), Expect = 1e-48 Identities = 176/644 (27%), Positives = 261/644 (40%), Gaps = 124/644 (19%) Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603 CG L ++G +P FP+ YP C W I+V I L F S + + YD++ Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1663 + DG +PL+G F K+PE + S+ + + + FRS ++ GF Y+A +C Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEA----TC-- 464 Query: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCG 1723 G MN DAG + DD RP C Sbjct: 465 -GGDMNK-----------------DAGQIQSPN------YPDDYRPS---------KECV 491 Query: 1724 SRSTGSEGTVLSPNYPKNYSVGH-NCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPT 1782 R T SEG + + H +C Y D +EV DGPT Sbjct: 492 WRITVSEGFHVGLTFQAFEIERHDSCAY----------------------DYLEVRDGPT 529 Query: 1783 QQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVPRTSSTQCSS 1840 ++S+L+ G E + SS N++ ++F S G I GF +F + +CS Sbjct: 530 EESALIGHFCGYEKPEDVK-SSSNRLWMKFVSDGSINKAGFAANFFKEV------DECSW 582 Query: 1841 VPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1900 R N S C+PGY L + C V CG Sbjct: 583 PDHGGCEHRCVNTL---GSYKCACDPGYELAADKKM------------------CEVACG 621 Query: 1901 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLDFY 1956 G +TK GTI SPG+P+ Y N NCVW++ P I +Q F E N +D ++ Sbjct: 622 GFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVR 681 Query: 1957 DGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQ 2016 G +A G + G+ P ++ S SNN+ + F+SD +VS GF + + D C + Sbjct: 682 SGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFS-DKDECAK-- 738 Query: 2017 TPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMS 2076 + G + G + +C GY L + H C A C +S Sbjct: 739 -DNGGCQHECVNTFGSYLC-RCRNGYWLHENGH-DCKE--------------AGCAHKIS 781 Query: 2077 DFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS----TETIHDYLEVRSGSS 2132 G + SP +P YPS +CTW I+ G V L F F E +D+LE+ G Sbjct: 782 SVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPD 841 Query: 2133 ETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVY 2176 + ++GR G + P ++ L F+SD S ++GF V+ Sbjct: 842 SLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVH 885 Score = 187 bits (474), Expect = 2e-46 Identities = 144/469 (30%), Positives = 218/469 (46%), Gaps = 64/469 (13%) Query: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124 A CGG M+ +G I SP +P +Y S +C W I + GF V L F F E +DY Sbjct: 462 ATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDY 521 Query: 2125 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHI-VYQAYQLQS 2183 LEVR G +E S +IG G + P + S+++ + F SD S NK GF ++ S Sbjct: 522 LEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECS 581 Query: 2184 CPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALC 2243 PD + V T+G + C PGY L + + CE C Sbjct: 582 WPDHGGCEHRCVN----TLG-SYKCACDPGYELAADKKM----------------CEVAC 620 Query: 2244 GGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITV 2299 GG IT +NGTI SPG+P EYP ++C W V P I + F V + E YDF+ V Sbjct: 621 GGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEV 680 Query: 2300 WDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFVLSYHAYQLRVCQP 2357 G ++ G+F G+ E + S SN + ++F SD T S GF Sbjct: 681 RSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGF--------------- 725 Query: 2358 PPPVPNAEILTEDDE-FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLC 2416 A ++ DE + +++C+ F G+ + CR G L +G C+ Sbjct: 726 -----RAHFFSDKDECAKDNGGCQHECVNTF---GSYLCRCRNGYWLHENGHD--CKEAG 775 Query: 2417 PANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVL 2472 A+++ G + SP +PD YP+ + C W+IS G+ + + F+ E+ +D L Sbjct: 776 CAHKIS-SVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHL 834 Query: 2473 QVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR 2521 ++YDGP+ +P+L G + S G +FL++ +D +KGF+ Sbjct: 835 EMYDGPDSLAPILGRFCGSKKPDPTVAS-GSSMFLRFYSDASVQRKGFQ 882 Score = 187 bits (474), Expect = 2e-46 Identities = 137/474 (28%), Positives = 213/474 (44%), Gaps = 73/474 (15%) Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1601 A CGG++ +G I SPN+P Y S++C W ITV+ + + L F +F IE + YD+ Sbjct: 462 ATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDY 521 Query: 1602 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1661 L + DGP S LIG F + PE ++SSSN + + F SDGS++ GF + ++ E Sbjct: 522 LEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECS 581 Query: 1662 F-DPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717 + D G G +++ +T+ Y CD GY L + Sbjct: 582 WPDHG--------GCEHRCVNTLGSYKCACDPGYELAADKKM------------------ 615 Query: 1718 CHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV--- 1774 C CG T GT+ SP +PK Y NCV+ + P ++ + QF F+ +DV Sbjct: 616 CEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKY 675 Query: 1775 --VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAV 1830 VEV G + + L GS + E + S N + + F S ++ +GF HF Sbjct: 676 DFVEVRSGLSPDAKLHGRFCGSETPEVI-TSQSNNMRVEFKSDNTVSKRGFRAHFF---- 730 Query: 1831 PRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWND 1890 + +C+ N F S L C GY LH + C+ Sbjct: 731 --SDKDECAK-DNGGCQHECVNTF---GSYLCRCRNGYWLHEN-GHDCKE---------- 773 Query: 1891 SLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN- 1949 C ++ +GT+ SP +P+ Y + C W I+ G +++ F E + Sbjct: 774 ------AGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQ 827 Query: 1950 ---WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGF 2000 +D L+ YDG D+ AP LG + G+ P ++ ++++L F SD SV GF Sbjct: 828 ECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGF 881 Score = 184 bits (467), Expect = 1e-45 Identities = 137/465 (29%), Positives = 209/465 (44%), Gaps = 59/465 (12%) Query: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGD-----V 1253 A CG + G + SPNYP +Y + EC++ I V G + ++ + F + + D Sbjct: 462 ATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDY 521 Query: 1254 LKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313 L++ DG + + L+G F G + + S+SN+LW++F SD GF + E+ Sbjct: 522 LEVRDGPTEESALIGHFCGYE-KPEDVKSSSNRLWMKFVSDGSINKAGFAANFFK-EVDE 579 Query: 1314 CEDPGIPQFGYK-ISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1372 C P ++ ++ G + + C+PGY L + C Sbjct: 580 CSWPDHGGCEHRCVNTLGSYKCA-----CDPGYELAADKKM----------------CEV 618 Query: 1373 ECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS----HDI 1428 CGG F + +G I SPG+P Y N C+W + +SLQF F+ E + +D Sbjct: 619 ACGG-FITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDF 677 Query: 1429 LRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATAC 1488 + V G + L GS PE I S N + ++F +D +SK GF F S Sbjct: 678 VEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECA 737 Query: 1489 RDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1548 +D G + N G + + +C GY L E C + A C Sbjct: 738 KDNGGCQHECVNTFG-----SYLCRCRNGYWLH-ENGHDCKE---------------AGC 776 Query: 1549 GGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYI 1604 ++ G + SPN+P YP R+C W I+ A + + L F F IE + YD L + Sbjct: 777 AHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEM 836 Query: 1605 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGF 1649 YDGPDS +P++G F SK P+ +S ++M L F SD SV GF Sbjct: 837 YDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGF 881 Score = 176 bits (446), Expect = 4e-43 Identities = 138/482 (28%), Positives = 212/482 (43%), Gaps = 60/482 (12%) Query: 842 VMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQ 901 ++ G A CGG + +G I SP +P Y+ S C W I G + +TF+ F+ Sbjct: 451 ILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFE 510 Query: 902 TELN----YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFK 957 E + YD LEV DGP S L+G + G + P+ + SSSN +++ F +D S + GF Sbjct: 511 IERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGF- 569 Query: 958 IHYESVTVNTYSCLDP-GIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWW 1016 N + +D P HG + + +CD GY L+ ++ + Sbjct: 570 ------AANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKM-------- 615 Query: 1017 SHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED 1076 C+ CGG + +GTI SPG+P+ YP + NC W V + F F LE Sbjct: 616 ------CEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEG 669 Query: 1077 H----HDYLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFN 1131 + +D++ + S L R GS+ P I + N R + F SD ++S GF Sbjct: 670 NDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITS-QSNNMRVE--FKSDNTVSKRGFR 726 Query: 1132 ITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWS 1191 F E +D G Q+ F + C +GY L C G Sbjct: 727 AHFFSDKDECAKDNGGCQHECVNTFG-----SYLCRCRNGYWLHENGH-DCKEAG----- 775 Query: 1192 APLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG 1251 C ++ EG L SPN+P Y + EC ++I AG + ++ F + Q Sbjct: 776 ---------CAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQH 826 Query: 1252 -----DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1306 D L++YDG D +LG F G+ T++S S+ ++L F SD +GFQ V+ Sbjct: 827 QECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSS-MFLRFYSDASVQRKGFQAVH 885 Query: 1307 TS 1308 ++ Sbjct: 886 ST 887 Score = 159 bits (401), Expect = 6e-38 Identities = 156/621 (25%), Positives = 261/621 (42%), Gaps = 115/621 (18%) Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255 ACG T++ ++G S+P FPN Y + + C W I PG+ I L FT + + YDY+ Sbjct: 350 ACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYV 409 Query: 256 EIEGS----EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311 E+ P G IP P++S + L + F + SN +GF A Y+ Sbjct: 410 EVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEA------- 462 Query: 312 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTS 371 T G++ + G I + P D +R S+E ++T + Sbjct: 463 TCGGDMNKD----AGQIQSPNYPDD-----------YRPSKECVWRITVSEGFHVGLTFQ 507 Query: 372 KDGLSPHPA---DTQSTRRRPRHAEQIERTKELAVVTH--RVKKAIDFKSRGFKLFPGKD 426 + H + D R P T+E A++ H +K D KS +L+ Sbjct: 508 AFEIERHDSCAYDYLEVRDGP--------TEESALIGHFCGYEKPEDVKSSSNRLW---- 555 Query: 427 NSNKFSILNEGGIKTA---SNLCPDPGE---PENGKRIGSDFSLGSTVQFSCDEDYVLQG 480 +++G I A +N + E P++G + + + +CD Y L Sbjct: 556 ----MKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAA 611 Query: 481 AKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITA 540 K + C+V CG + +GT TSP +P +Y +N CVW + A Sbjct: 612 DKKM------------------CEV-ACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVA 652 Query: 541 VNTNKVIQINFEEFDLE----IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQ 596 + I + FE F+LE YD + + G + + GS P++I S S+ Sbjct: 653 PAQYR-ISLQFEVFELEGNDVCKYDFVEVRSG--LSPDAKLHGRFCGSETPEVITSQSNN 709 Query: 597 MWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRF-----ECQ 651 M + ++D +V GF+ ++ +K+ C ++ G + V F C+ Sbjct: 710 MRVEFKSDNTVSKRGFRAHFFS-DKDECA---------KDNGGCQHECVNTFGSYLCRCR 759 Query: 652 FGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTI 711 G+ L E C+E C ++ GT+ SP++P+ Y + C W I Sbjct: 760 NGYWL-HENGHDCKEAG------------CAHKISSVEGTLASPNWPDKYPSRRECTWNI 806 Query: 712 ISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHIL 767 S G R+ L+FN+F++E +D L + DG +PILG F G++ P ++ + Sbjct: 807 SSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSM 866 Query: 768 RLEFQADHSMSGRGFNITYNT 788 L F +D S+ +GF ++T Sbjct: 867 FLRFYSDASVQRKGFQAVHST 887 Score = 143 bits (360), Expect = 4e-33 Identities = 160/648 (24%), Positives = 249/648 (38%), Gaps = 124/648 (19%) Query: 1024 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1079 +A CGGD+ +G I SP YP+ Y S C W + V+ G V F F +E H +D Sbjct: 461 EATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520 Query: 1080 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138 YL + + + L G + P + + + R ++F+SD SI+ GF F + Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKS---SSNRLWMKFVSDGSINKAGFAANFFK-E 576 Query: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 ++ C P R G + +C GY L +A C Sbjct: 577 VDECSWPDHGGCEHRCVNTLG---SYKCACDPGYEL----------------AADKKMCE 617 Query: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1255 CG T G + SP +P Y N C++ + A I++ F L DV K Sbjct: 618 VACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDF 677 Query: 1256 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313 + G L G F G+ + ++S SN + +EF SD + GF+ + S + Sbjct: 678 VEVRSGLSPDAKLHGRFCGSETPEV-ITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDEC 736 Query: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGC-NPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1372 +D G GC + GS L +C G W + Sbjct: 737 AKDNG---------------------GCQHECVNTFGSYLCRCRNG---YWLHENGHDCK 772 Query: 1373 ECGGRFKGES-SGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFD----TEASHD 1427 E G K S G + SP +P Y + C W I G+ V L F F+ E ++D Sbjct: 773 EAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYD 832 Query: 1428 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1487 L ++DGP +L GS P+ ++ + + ++F +D + + GF S T Sbjct: 833 HLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHS----TE 888 Query: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQV-ENRYFWQPSPPVCIA 1546 C GR E+Q +E + Q +N Y PS A Sbjct: 889 C-------------GGRLKA-----------EVQTKELYSHAQFGDNNY---PSE----A 917 Query: 1547 PCGGNLTGSSGFILSPNF-PHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605 C + G+ + F DC + DY+ + YD Sbjct: 918 RCDWVIVAEDGYGVELTFRTFEVEEEADCGY------DYMEA-----------YD----- 955 Query: 1606 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1653 G DS++P +G F S E I S+ +++ + FR+D +++ GFH Y Sbjct: 956 -GYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002 Score = 113 bits (282), Expect = 4e-24 Identities = 83/313 (26%), Positives = 136/313 (43%), Gaps = 44/313 (14%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 80 CGG + LNGTI SPG+P YP NC W ++A + RI + F+ F LE +YD++ Sbjct: 620 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVE 679 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139 + G R G P +TS + + SD VS GF+ ++ + + Sbjct: 680 VRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKD 739 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYIL--DGHPQLTCIANSVNTASWDFPVPICRA 197 N G + V + C GY L +GH C+ Sbjct: 740 NGGCQHECV------NTFGSYLCRCRNGYWLHENGHD--------------------CK- 772 Query: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253 E C + G ++SP++P++Y + +CTW I + G + L F +F++E+ YD Sbjct: 773 EAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYD 832 Query: 254 YLEI----EGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY--QGSST 307 +LE+ + P G P P +++ + + L F +D++ + +GF A + + Sbjct: 833 HLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGR 892 Query: 308 LTHTTSTGELEEH 320 L T EL H Sbjct: 893 LKAEVQTKELYSH 905 Score = 111 bits (277), Expect = 2e-23 Identities = 81/292 (27%), Positives = 123/292 (42%), Gaps = 38/292 (13%) Query: 24 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 79 TCGG + G I+SP +P Y C W I E + + FQ+F +E YDYL Sbjct: 463 TCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYL 522 Query: 80 SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSC 138 + DG + G+ P V S+ + ++ SD +++ GF +++E+ S Sbjct: 523 EVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSW 582 Query: 139 GNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE 198 P G + + +C GY L ++ E Sbjct: 583 -----PDHGGCEHRCVNTLGSYKCACDPGYELAADKKM--------------------CE 617 Query: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDY 254 ACGG + +G I+SP +P EY N +C W +VA ISL F F++E KYD+ Sbjct: 618 VACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDF 677 Query: 255 LEIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 +E+ P L G P I S N +R+ F +D+ RGF A + Sbjct: 678 VEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHF 729 Score = 108 bits (270), Expect = 1e-22 Identities = 83/299 (27%), Positives = 134/299 (44%), Gaps = 40/299 (13%) Query: 2240 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2295 EA CGG++ G I SP YPD+Y ++C W + V G + + F + E YD Sbjct: 461 EATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520 Query: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2353 ++ V DGP + S IG F G E V S+SN++ +KF SD +GF Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGF----------- 569 Query: 2354 VCQPPPPVPNAEILTEDDEFEIGDI--IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV 2411 A E DE D ++C+ +G+ C G L D + Sbjct: 570 ---------AANFFKEVDECSWPDHGGCEHRCV---NTLGSYKCACDPGYELAAD--KKM 615 Query: 2412 CQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK---- 2467 C+V C +L+ G I SPG+P YP + C W + Y I++ E F+ E Sbjct: 616 CEVACGGFITKLN--GTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVC 673 Query: 2468 EFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526 ++D ++V G + + + G + ITS + + +++ +D+ +K+GFR + + Sbjct: 674 KYDFVEVRSGLSPDAKLHGRFCGSETPEV-ITSQSNNMRVEFKSDNTVSKRGFRAHFFS 731 Score = 87.4 bits (215), Expect = 2e-16 Identities = 72/294 (24%), Positives = 121/294 (41%), Gaps = 68/294 (23%) Query: 503 CKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----I 558 CK C + GT SPN+P +Y S +C W I++ ++V ++ F EF++E Sbjct: 771 CKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRV-KLTFNEFEIEQHQEC 829 Query: 559 GYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKE 618 YD L + DG + P +L GS PD V+ S M+L +D SV GF+ Sbjct: 830 AYDHLEMYDGPDSLAP--ILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQA---- 883 Query: 619 IEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICI 678 + CG G ++ + +S+ QFG +NN Sbjct: 884 VHSTECG--GRLKAEVQTKELYSH-------AQFG------------DNN---------- 912 Query: 679 FPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDF 734 Y + C W I+++ G + L+F F++E + +D+ Sbjct: 913 ----------------------YPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDY 950 Query: 735 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 788 + DG +P LG F G+ + S L + F+ D +++ +GF+ Y + Sbjct: 951 MEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTS 1004 Score = 70.1 bits (170), Expect = 4e-11 Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 7/114 (6%) Query: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2293 L +C A CG + G +PG+P+ YP++ C W + V PG I +NFT + Sbjct: 345 LYKCPA-CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRL 403 Query: 2294 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFF 2343 YD++ V DG + +P +G+F G+ E + ST +++ ++F S+ GFF Sbjct: 404 CWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFF 457 Score = 67.8 bits (164), Expect = 2e-10 Identities = 38/112 (33%), Positives = 55/112 (49%), Gaps = 4/112 (3%) Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2126 CG + D +G +PGFP YPS C W I++ G + L F + S +DY+E Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410 Query: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 VR G + ++GR G +IP L ST + F S + +GF Y+A Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEA 462 Score = 64.7 bits (156), Expect = 2e-09 Identities = 38/119 (31%), Positives = 55/119 (46%), Gaps = 8/119 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CG TL+ G +PGFP GYP+ ++C W I +I + F S L + YDY+ Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 + DG+ R G +P P+ ST S + S + GF YE ++CG Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYE----ATCG 465 Score = 63.9 bits (154), Expect = 3e-09 Identities = 42/145 (28%), Positives = 61/145 (42%), Gaps = 8/145 (5%) Query: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253 E CGG M +G I SP++P++Y + +C W I G + L F F++E YD Sbjct: 461 EATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520 Query: 254 YLEIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309 YLE+ L G P + S+ N L + FV+D + GF+A + Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC 580 Query: 310 HTTSTGELEEHNRTTTGAIAVASTP 334 G E T G+ A P Sbjct: 581 SWPDHGGCEHRCVNTLGSYKCACDP 605 Score = 63.2 bits (152), Expect = 5e-09 Identities = 40/130 (30%), Positives = 66/130 (50%), Gaps = 5/130 (3%) Query: 837 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 896 L G + + + KC A CG +G +PG+P Y +C W I PG I + Sbjct: 334 LSQGDIAQARKLYKCPA-CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLN 392 Query: 897 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 952 F + F++ L YD +EV DG +PLLG + G ++P+ L S+ + +++ F + ++ Sbjct: 393 FTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNIL 452 Query: 953 NNGFKIHYES 962 GF YE+ Sbjct: 453 GKGFFAAYEA 462 Score = 63.2 bits (152), Expect = 5e-09 Identities = 54/208 (25%), Positives = 83/208 (39%), Gaps = 32/208 (15%) Query: 776 SMSGRGFNITYNTFG---HNEC----------PDPGIPINARRFGDNFQLGSSISVICEE 822 S +G +T+N F H EC PD PI R G + S Sbjct: 808 STAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVAS----- 862 Query: 823 GFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAP--SGVILSPGWPG--YYKDS 878 G+ D V G CGG A + + S G Y Sbjct: 863 ------GSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSE 916 Query: 879 LNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSYNGTQVPQFL 934 C+WVI AE G+ +++TF F+ E YD +E +DG + +P LG + G+ + + Sbjct: 917 ARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEI 976 Query: 935 FSSSNFIYLLFTTDNSRSNNGFKIHYES 962 +S+ + + + F TD++ + GF Y S Sbjct: 977 YSAGDSLMIRFRTDDTINKKGFHARYTS 1004 Score = 62.0 bits (149), Expect = 1e-08 Identities = 32/104 (30%), Positives = 56/104 (53%), Gaps = 8/104 (7%) Query: 2243 CGGNITAMNGT--IYSPGY--PDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----Y 2294 CGG + A T +YS + YP+ C W++ G G+ + F + E Y Sbjct: 889 CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGY 948 Query: 2295 DFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFT 2338 D++ +DG D ++P++G+F G+ LE +YS + ++I+F +D T Sbjct: 949 DYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDT 992 Score = 61.2 bits (147), Expect = 2e-08 Identities = 35/116 (30%), Positives = 59/116 (50%), Gaps = 8/116 (6%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNL----NCVWKITVPEGAGIQVQVVSFATEHN----W 1950 CGG L T + + DNN C W I +G G+++ +F E + Sbjct: 889 CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGY 948 Query: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA 2006 D ++ YDG D++APRLG + G+ + S ++L + F++D +++ GFH YT+ Sbjct: 949 DYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTS 1004 Score = 56.6 bits (135), Expect = 4e-07 Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 4/97 (4%) Query: 2090 NYPSSLDCTWTINLPIGFGVHLQFVNFSTETI----HDYLEVRSGSSETSTVIGRLSGPQ 2145 NYPS C W I G+GV L F F E +DY+E G ++ +GR G Sbjct: 912 NYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSG 971 Query: 2146 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQ 2182 ++S + F +D + NK+GFH Y + + Q Sbjct: 972 PLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQ 1008 Score = 56.2 bits (134), Expect = 6e-07 Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 8/114 (7%) Query: 25 CGGTLKGLNGTIESPGFPY----GYPNGANCTWVIIAEERNRIQIVFQSFALEEE----Y 76 CGG LK T E YP+ A C WVI+AE+ +++ F++F +EEE Y Sbjct: 889 CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGY 948 Query: 77 DYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 130 DY+ YDG+ R G + S +R +D ++ GF Y Sbjct: 949 DYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002 Score = 54.7 bits (130), Expect = 2e-06 Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 7/118 (5%) Query: 1373 ECGGRFKGESSGRILSPGYPFP---YDNNLRCMWMIEVDPGNIVSLQFLAFDTE----AS 1425 ECGGR K E + L F Y + RC W+I + G V L F F+ E Sbjct: 888 ECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCG 947 Query: 1426 HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSS 1483 +D + +DG + L GS E I+S + + I+F TD I+K GF +++S+ Sbjct: 948 YDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTST 1005 Score = 51.6 bits (122), Expect = 1e-05 Identities = 40/122 (32%), Positives = 60/122 (49%), Gaps = 7/122 (5%) Query: 1713 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1769 R L C A CG + G +P +P Y +CV+ I+V P E +V F F++ Sbjct: 343 RKLYKCPA-CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKS 401 Query: 1770 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827 L +D VEV DG +++ LL G E L +S+ +++ + F S I KGF Y Sbjct: 402 RLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPL-VSTDSRLWVEFRSSSNILGKGFFAAY 460 Query: 1828 QA 1829 +A Sbjct: 461 EA 462 Score = 51.2 bits (121), Expect = 2e-05 Identities = 34/118 (28%), Positives = 57/118 (48%), Gaps = 7/118 (5%) Query: 1194 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1251 L +C A CG + + G +P +P Y + C++ I V G+ I ++ + L + Sbjct: 345 LYKCPA-CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRL 403 Query: 1252 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1306 D +++ DG + LLG F G + L ST ++LW+EF S + +GF Y Sbjct: 404 CWYDYVEVRDGYWRKAPLLGRFCGDKIPE-PLVSTDSRLWVEFRSSSNILGKGFFAAY 460 Score = 51.2 bits (121), Expect = 2e-05 Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 5/93 (5%) Query: 2436 DSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQSPVLISLSGD 2491 ++YP+ C W I E GY + + F+ E+E +D ++ YDG + +P L G Sbjct: 911 NNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGS 970 Query: 2492 YSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2524 I S G + +++ D NKKGF RY Sbjct: 971 -GPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002 Score = 49.3 bits (116), Expect = 7e-05 Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 12/114 (10%) Query: 201 CGGTMRG---SSGIISSPSF-PNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----Y 252 CGG ++ + + S F N Y + A C W IVAE G + L F F++EE+ Y Sbjct: 889 CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGY 948 Query: 253 DYLE----IEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 DY+E + S P G I S + L + F TD +GF A Y Sbjct: 949 DYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002 Score = 47.8 bits (112), Expect = 2e-04 Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 6/116 (5%) Query: 2416 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2470 CPA E D+TG +PG+P+ YP+ C W ISV G I + K +D Sbjct: 348 CPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYD 407 Query: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526 ++V DG ++P+L GD + S +++++ + KGF Y A Sbjct: 408 YVEVRDGYWRKAPLLGRFCGD-KIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEA 462 Score = 44.3 bits (103), Expect = 0.002 Identities = 27/94 (28%), Positives = 44/94 (46%), Gaps = 6/94 (6%) Query: 1220 NYENNHECIYSIQVQAGKGINISARTFHLAQG-----DVLKIYDGKDKTTHLLGAFTGAS 1274 NY + C + I + G G+ ++ RTF + + D ++ YDG D + LG F G+ Sbjct: 912 NYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSG 971 Query: 1275 MRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308 + S + L + F +D +GF YTS Sbjct: 972 PLE-EIYSAGDSLMIRFRTDDTINKKGFHARYTS 1004 Score = 34.7 bits (78), Expect = 1.8 Identities = 20/56 (35%), Positives = 28/56 (50%), Gaps = 1/56 (1%) Query: 1772 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827 +D +E YDG + L GS E + S+G+ + IRF + I KGFH Y Sbjct: 948 YDYMEAYDGYDSSAPRLGRFCGSGPLEEI-YSAGDSLMIRFRTDDTINKKGFHARY 1002 >gi|187960042 selectin E precursor [Homo sapiens] Length = 610 Score = 206 bits (525), Expect = 3e-52 Identities = 122/401 (30%), Positives = 183/401 (45%), Gaps = 21/401 (5%) Query: 2817 CQQDHNWSG----QLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2872 C+ D +SG Q+ +C + GS + GN F++N + SC+ GYL Sbjct: 163 CKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMET 221 Query: 2873 AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGS 2932 QC ++ +WS P P C VV C PAN E G+F + T +DC G+ L G+ Sbjct: 222 MQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGA 281 Query: 2933 SVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL------SGEKYTFGSTVHYSCTGKRS 2986 L C +G WD P C + C P N + +GE +TF S+ +++C Sbjct: 282 QSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGE-FTFKSSCNFTCEEGFM 340 Query: 2987 LLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDP--GTPGHGSRQESNFRTKSTVRYACDT 3044 L G + C G W+ P C +P G +FR S+ ++C+ Sbjct: 341 LQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQ 400 Query: 3045 GYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKV----FRIDGTTFSSSVIYS 3100 G++L GS+ C G W +P C+AV+C G V I T+ SS +S Sbjct: 401 GFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFS 460 Query: 3101 CMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN-GLRYGDDYVVGQNVSYMC 3159 C EG+ L G + +CT+ G W+ +P+C ++ C +P + + V G + C Sbjct: 461 CEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFAC 520 Query: 3160 QPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQIS 3200 G+T LNGS RTC G WSG++PTC A T P ++ Sbjct: 521 PEGWT--LNGSAARTCGATGHWSGLLPTCEAPTESNIPLVA 559 Score = 164 bits (415), Expect = 1e-39 Identities = 120/434 (27%), Positives = 174/434 (40%), Gaps = 42/434 (9%) Query: 3013 TGTCGDPGTPGHGSRQES--NFRTKSTVRYACDTGYI-LHGSEERTCLANGSWTGRQPEC 3069 T C + GHG E+ N+ K CD G+ L + C A S PE Sbjct: 140 TAACTNTSCSGHGECVETINNYTCK------CDPGFSGLKCEQIVNCTALES-----PEH 188 Query: 3070 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129 ++ C +P + +++SS SC GY+ S QC ++G WS +P C Sbjct: 189 GSLVCSHP----------LGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACN 238 Query: 3130 IISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM 3185 ++ C PANG + + ++ C+ G+ EL G++ CT +G W Sbjct: 239 VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGF--ELMGAQSLQCTSSGNWDNEK 296 Query: 3186 PTCRAVTCPTPPQISNGRLEGTN-----FDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3240 PTC+AVTC Q NG + ++ F + S ++ C G+ L PA + C G W+ Sbjct: 297 PTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWT 356 Query: 3241 GEVPQCLPKFCGDPGIPAQG-----KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADG 3295 ++P C C P +G SF Y S FSC F+L GS C G Sbjct: 357 QQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG 416 Query: 3296 TWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG-FQVGSVVQFHCKKGHLLQGSTTRTCL 3354 W P C + P ++ G F S F C++G L GST C Sbjct: 417 EWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECT 476 Query: 3355 PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCR 3414 W+ P C C P N+ P G + C G+ L G+ R C Sbjct: 477 SQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTL-NGSAARTCG 535 Query: 3415 SDNTWTGKVPICEA 3428 + W+G +P CEA Sbjct: 536 ATGHWSGLLPTCEA 549 Score = 160 bits (405), Expect = 2e-38 Identities = 110/380 (28%), Positives = 160/380 (42%), Gaps = 30/380 (7%) Query: 2529 CSTPESPPHGYII-SQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVP 2585 C+ ESP HG ++ S G NS +CDRG+ + C S W AP+P Sbjct: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSG----EWSAPIP 235 Query: 2586 ACQAISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2641 AC + C P NG + + T T+ C +G+ L + + C S G W Sbjct: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ--SLQCTSSGNWD 293 Query: 2642 NHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLP 2701 N P C VTC ++ R + +K+ F+C+ G+ GPA +EC Sbjct: 294 NEK--PTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351 Query: 2702 NGTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTS---YGSTAIFTCDLGFMLVGSAV 2756 G W+ + P C+ C L P G N + + + YGS+ F+C+ GF+L GS Sbjct: 352 QGQWT--QQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKR 409 Query: 2757 RECLSSGLWSESETRCLAGHCGIPELIVNGQV------IGENYGYRDTVVYQCNPGFRLI 2810 +C +G W + C A C G V IGE + Y+ + + C GF L Sbjct: 410 LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE-FTYKSSCAFSCEEGFELH 468 Query: 2811 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN-FNDVVTFSCNIGYLMQG 2869 GS+ C W+ ++PSC V C P S +G F V F+C G+ + G Sbjct: 469 GSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNG 528 Query: 2870 PTKAQCQANRQWSHPPPMCK 2889 C A WS P C+ Sbjct: 529 SAARTCGATGHWSGLLPTCE 548 Score = 159 bits (402), Expect = 5e-38 Identities = 107/385 (27%), Positives = 159/385 (41%), Gaps = 37/385 (9%) Query: 2948 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRT--CQLNGHWSGSQ 3005 PE + C HP +++ S+ SC R L S T C +G WS Sbjct: 186 PEHGSLVCSHPL---------GNFSYNSSCSISCD--RGYLPSSMETMQCMSSGEWSAPI 234 Query: 3006 PHCSGDATGTCGDPGTPGHGS----RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 3061 P C+ C P +G + +F +T + C+ G+ L G++ C ++G+ Sbjct: 235 PACN---VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN 291 Query: 3062 WTGRQPECKAVQCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTA 3117 W +P CKAV C NG V TF SS ++C EG++L GP+ +CT Sbjct: 292 WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351 Query: 3118 NGTWSGTLPNCTIISCGDPGIPANGLRY-----GDDYVVGQNVSYMCQPGYTMELNGSRI 3172 G W+ +P C C P G + G + + C+ G+ L GS+ Sbjct: 352 QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFV--LKGSKR 409 Query: 3173 RTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN-----FDWGFSISYICSPGYELSF 3227 C G W PTC AV C Q G + + F + S ++ C G+EL Sbjct: 410 LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHG 469 Query: 3228 PAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSF-IYQSEVSFSCNFPFILVGS 3286 L C G W+ EVP C C +P + ++ + F+C + L GS Sbjct: 470 STQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGS 529 Query: 3287 STRICQADGTWSGSSPHCIEPTQTS 3311 + R C A G WSG P C PT+++ Sbjct: 530 AARTCGATGHWSGLLPTCEAPTESN 554 Score = 94.4 bits (233), Expect = 2e-18 Identities = 65/234 (27%), Positives = 94/234 (40%), Gaps = 22/234 (9%) Query: 2550 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGI-----L 2604 S + C+ GF L G + C W +P C+A C P G + Sbjct: 329 SSCNFTCEEGFMLQGPAQVECTTQGQ----WTQQIPVCEAFQCTALSNPERGYMNCLPSA 384 Query: 2605 TTDYLVGTRVTYFCNDGYRLS-SKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILE 2663 + + G+ + C G+ L SK L C G W N P C V C +++ Sbjct: 385 SGSFRYGSSCEFSCEQGFVLKGSKRLQ---CGPTGEWDNEK--PTCEAVRCDAVHQ--PP 437 Query: 2664 HGRWRIVNG--SHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGE 2721 G R + + YK+ FSC+ G+ G +EC G W+ E P CQ++ C Sbjct: 438 KGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWT--EEVPSCQVVKCSS 495 Query: 2722 LPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA 2774 L P N + +G+ F C G+ L GSA R C ++G WS C A Sbjct: 496 LAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549 Score = 75.5 bits (184), Expect = 9e-13 Identities = 45/176 (25%), Positives = 72/176 (40%), Gaps = 5/176 (2%) Query: 3266 SFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNN 3325 +F Y S S SC+ ++ T C + G WS P C + NP N Sbjct: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258 Query: 3326 TFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGM 3385 F + F C++G L G+ + C W +P C +C+ P + +V Sbjct: 259 PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318 Query: 3386 DLPSHGYTLI----YTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3437 P+ +T +TC+ GF L G + C + WT ++P+CEA + +P Sbjct: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVE-CTTQGQWTQQIPVCEAFQCTALSNP 373 Score = 57.0 bits (136), Expect = 3e-07 Identities = 103/471 (21%), Positives = 165/471 (35%), Gaps = 115/471 (24%) Query: 952 SNNGFKIHYESV-TVNTYSC-LDPGI----------------PVHGRRY-GH---DFSIG 989 +N H E V T+N Y+C DPG P HG H +FS Sbjct: 144 TNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYN 203 Query: 990 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPN 1049 S+ S SCD GY S E + C + WS P+P C+ + V P+ G+ E + N Sbjct: 204 SSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPAN-----GFVECFQN 258 Query: 1050 SLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGL 1109 + W TF E+ + L G+ ++G Sbjct: 259 PGSFPWNTTC-----------TFDCEEGFE----------------LMGAQSLQCTSSGN 291 Query: 1110 YGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGS-----RIGFNFGIGDTL 1164 + N + + ++ C PQ GS F + Sbjct: 292 WDNEKPTCKAVT--------------------CRAVRQPQNGSVRCSHSPAGEFTFKSSC 331 Query: 1165 TFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGIL-LSPNYPLNYE 1222 F+C G+ L+G +++ C G+ W+ +P C A +C A + G + P+ ++ Sbjct: 332 NFTCEEGFMLQGPAQVECTTQGQ--WTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFR 389 Query: 1223 NNHECIYSIQV-------------QAGKGINISARTFHLAQGDVLKIYDGKDKTTHL-LG 1268 C +S + G+ N + V + G + H +G Sbjct: 390 YGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIG 449 Query: 1269 AFTGASM------RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP-Q 1321 FT S G L ++ LE S + T+E S ++ C +P + Sbjct: 450 EFTYKSSCAFSCEEGFELHGSTQ---LECTSQGQWTEE-----VPSCQVVKCSSLAVPGK 501 Query: 1322 FGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1372 S + F G+ + C G+TL+GS+ C G W LP+C A Sbjct: 502 INMSCSGEPVF-GTVCKFACPEGWTLNGSAARTC--GATGHWSGLLPTCEA 549 Score = 52.4 bits (124), Expect = 8e-06 Identities = 65/276 (23%), Positives = 107/276 (38%), Gaps = 40/276 (14%) Query: 1681 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYP 1739 +T T+ C+ G+ L G +L C + W+ P+C A C + G+V + P Sbjct: 266 TTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321 Query: 1740 KN-YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSG- 1797 ++ +C ++ + F++ G T+ + P ++ ++LS G Sbjct: 322 AGEFTFKSSCNFTCE--EGFMLQGPAQVECTTQGQWTQQI--PVCEAFQCTALSNPERGY 377 Query: 1798 -ESLPLSSGN---QITIRFTSVGPITAKGFHFVY--------QAVPRTSSTQCSSVPEPR 1845 LP +SG+ + F+ KG + P + +C +V +P Sbjct: 378 MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPP 437 Query: 1846 FG------RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVP 1898 G IG EF SS F C G+ LHGS + C S QW + +P+C +V Sbjct: 438 KGLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLEC----TSQGQWTEEVPSCQVVK 492 Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEG 1934 C + K + G P V K PEG Sbjct: 493 CSSLAVPGKINMSCSGEPV-----FGTVCKFACPEG 523 Score = 51.2 bits (121), Expect = 2e-05 Identities = 57/251 (22%), Positives = 87/251 (34%), Gaps = 63/251 (25%) Query: 446 CPDPGEPENG-----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHR 500 C PE G F GS+ +FSC++ +VL+G+K + C E W + + Sbjct: 367 CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE----WDNEK 422 Query: 501 PVCKVKTCGSNLQGPSGTFTSPNFPF-QYDSNAQCVWVITAVNTNKVIQINFEEFDLEIG 559 P C+ C + Q P G + P ++ + C + E F+L G Sbjct: 423 PTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE------------EGFELH-G 469 Query: 560 YDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEI 619 L G+ + QV+ S + +V K+N Sbjct: 470 STQLECTSQGQWTEEVPSCQVVKCSSL----------------------AVPGKINM--- 504 Query: 620 EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 679 SC G P++G V +F C G+ L G + C WS +P C Sbjct: 505 ---SCS--GEPVFG----------TVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549 Query: 680 PCLSNFTAPMG 690 P SN G Sbjct: 550 PTESNIPLVAG 560 Score = 50.4 bits (119), Expect = 3e-05 Identities = 40/154 (25%), Positives = 56/154 (36%), Gaps = 11/154 (7%) Query: 3291 CQADGTWSGSSPHCIEPTQTSCENPGVPRHGS---QNNTFGFQVGSVVQFHCKKGHLLQG 3347 C+ D +SG I +C P HGS + F S C +G+L Sbjct: 163 CKCDPGFSGLKCEQI----VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSS 218 Query: 3348 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH---GYTLIYTCQPGFFL 3404 T C+ WS P C C PA+ V P T + C+ GF L Sbjct: 219 METMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFEL 278 Query: 3405 AGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPR 3438 G + C S W + P C+A + V+ P+ Sbjct: 279 MGAQSLQ-CTSSGNWDNEKPTCKAVTCRAVRQPQ 311 Score = 48.1 bits (113), Expect = 2e-04 Identities = 69/287 (24%), Positives = 97/287 (33%), Gaps = 65/287 (22%) Query: 462 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQ-------- 513 F +T F C+E + L GA+S+ C W + +P CK TC + Q Sbjct: 262 FPWNTTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRC 317 Query: 514 --GPSGTFT---SPNF----------PFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI 558 P+G FT S NF P Q + Q W + + Q + E Sbjct: 318 SHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWT-QQIPVCEAFQCTALS-NPER 375 Query: 559 GYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESV--GSVGFKVNY 616 GY L +GSF S + L+ + + G G N Sbjct: 376 GY--------------MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNE 421 Query: 617 KEI-EKESCGDPGTPLYGIRE------GDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ 669 K E C P G+ G+ F+ + F C+ GFEL G + C Q Sbjct: 422 KPTCEAVRCDAVHQPPKGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQ 480 Query: 670 WSANIPICIFPCLSNFTAP------------MGTVLSPDYPEGYGNN 704 W+ +P C S+ P GTV PEG+ N Sbjct: 481 WTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLN 527 Score = 46.6 bits (109), Expect = 5e-04 Identities = 64/268 (23%), Positives = 104/268 (38%), Gaps = 32/268 (11%) Query: 793 ECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG 852 E P+ G + + G NF SS S+ C+ G++ + ET+ C + G+ WS IP C Sbjct: 184 ESPEHGSLVCSHPLG-NFSYNSSCSISCDRGYLPS-SMETMQC-MSSGE--WSAPIPACN 238 Query: 853 -APCGGHFSAPSGVI---LSPG-WPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYD 907 C + +G + +PG +P + +CE E S++ T + N+D Sbjct: 239 VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCT-----SSGNWD 293 Query: 908 ----VLEVHDGPNLLSPLLGSYNGTQVP--QFLFSSS-NFI----YLLFTTDNSRSNNGF 956 + + P GS + P +F F SS NF ++L Sbjct: 294 NEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG 353 Query: 957 KIHYESVTVNTYSCLDPGIPVHG-----RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE 1011 + + + C P G F GS+ FSC+ G+ L + L C Sbjct: 354 QWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCG 413 Query: 1012 KNHWWSHPLPTCDAL-CGGDVRGPSGTI 1038 W + PTC+A+ C + P G + Sbjct: 414 PTGEWDNEKPTCEAVRCDAVHQPPKGLV 441 Score = 45.1 bits (105), Expect = 0.001 Identities = 101/460 (21%), Positives = 145/460 (31%), Gaps = 118/460 (25%) Query: 446 CPDPGEPENGKRIGS----DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501 C PE+G + S +FS S+ SCD Y+ +++ C E WS P Sbjct: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIP 235 Query: 502 VCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561 C V C + +G P + N C FD E G++ Sbjct: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCT------------------FDCEEGFE 277 Query: 562 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 621 M +Q LQ S K K + Sbjct: 278 L------------------------------MGAQ---SLQCTSSGNWDNEKPTCKAVTC 304 Query: 622 ESCGDP--GTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC-I 678 + P G+ F+ + F C+ GF L G + C QW+ IP+C Sbjct: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364 Query: 679 FPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVK 738 F C T LS + GY +NC + S GS + S +F E F K Sbjct: 365 FQC---------TALS-NPERGY---MNC---LPSASGSFRYGSSCEFSCEQGFVLKGSK 408 Query: 739 ----------DGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMS---GRGFNIT 785 D + P + + P L +H EF S + GF + Sbjct: 409 RLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELH 468 Query: 786 YNTFGHNECPDPG-----IP---------------INARRFGDNFQLGSSISVICEEGFI 825 +T EC G +P IN G+ G+ C EG+ Sbjct: 469 GST--QLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV-FGTVCKFACPEGW- 524 Query: 826 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGV 865 G+ TC WSGL+P C AP + +G+ Sbjct: 525 TLNGSAARTC---GATGHWSGLLPTCEAPTESNIPLVAGL 561 Score = 43.1 bits (100), Expect = 0.005 Identities = 96/448 (21%), Positives = 148/448 (33%), Gaps = 100/448 (22%) Query: 1838 CSSVPEPRFGRRI-----GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSL 1892 C+++ P G + GN F+ SS C+ GY+ ++C S +W+ + Sbjct: 180 CTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMETMQCM----SSGEWSAPI 234 Query: 1893 PTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQ-VQVVSFATEHNW 1950 P C +V C + G + P + N C + EG + Q + + NW Sbjct: 235 PACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCE--EGFELMGAQSLQCTSSGNW 292 Query: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010 D N P + + + N + S S AG E+T Sbjct: 293 D---------NEKPTCKAVTCRAVRQPQNGSVR---------CSHSPAG---EFTF--KS 329 Query: 2011 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPI---- 2066 SC +F C++G+ LQG + + C +W IP+ Sbjct: 330 SC----------------------NFTCEEGFMLQGPAQVECTTQG--QWTQQIPVCEAF 365 Query: 2067 --------------CLAQCGGAMSDFSGVILS--PGFPGNYPSSLDC----TWTINLPIG 2106 CL G+ S S GF L C W P Sbjct: 366 QCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC 425 Query: 2107 FGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYS 2166 V V+ + + VR S IG + S FS L+ + Sbjct: 426 EAVRCDAVHQPPKGL-----VRCAHSP----IGEFTYKS--SCAFSCEEGFELHGSTQLE 474 Query: 2167 QNKQG-FHIVYQAYQLQSCPDPR-PFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTC 2224 QG + + Q+ C P + + G F C G+TL G++A TC Sbjct: 475 CTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC 534 Query: 2225 LHGVSRNWNHPLPRCEALCGGNITAMNG 2252 G + +W+ LP CEA NI + G Sbjct: 535 --GATGHWSGLLPTCEAPTESNIPLVAG 560 Score = 43.1 bits (100), Expect = 0.005 Identities = 60/292 (20%), Positives = 100/292 (34%), Gaps = 68/292 (23%) Query: 1830 VPRTSSTQCSSVPEPRFGR----RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1885 +P + +C +V P G + F ++ FDC G+ L G+ +++C S Sbjct: 234 IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQC----TSS 289 Query: 1886 AQWNDSLPTC-IVPCGGILTKRKGTIL---SPGYPEPYDNNLNCVWKITVPEGAGIQVQV 1941 W++ PTC V C + + G++ SP + ++ N T EG +Q Sbjct: 290 GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCN----FTCEEGFMLQGPA 345 Query: 1942 -VSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGF 2000 V T+ W P ++ T + S Y+N S S Sbjct: 346 QVECTTQGQW---------TQQIPVCEAFQCTAL-----SNPERGYMNCLPSASGS---- 387 Query: 2001 HLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060 + G F C+QG+ L+G + C GP W Sbjct: 388 ---------------------------FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGEW 418 Query: 2061 NYPIPICLA-QCGGAMSDFSGVILSPGFP-GNYPSSLDCTWTINLPIGFGVH 2110 + P C A +C G++ P G + C ++ GF +H Sbjct: 419 DNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE--EGFELH 468 Score = 43.1 bits (100), Expect = 0.005 Identities = 49/224 (21%), Positives = 76/224 (33%), Gaps = 63/224 (28%) Query: 1677 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLS 1735 ++ GS+ + C+ G+VL+G L C G G W+ P+C A C + +G V Sbjct: 388 FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGE--WDNEKPTCEAVRCDAVHQPPKGLVRC 443 Query: 1736 PNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSH 1795 + P G+F + + E ++ H Sbjct: 444 AHSP---------------------IGEFTYKSSCAFSCEEGFE--------------LH 468 Query: 1796 SGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEP-RFGRRIGNEF 1854 L +S Q T + VP +CSS+ P + E Sbjct: 469 GSTQLECTSQGQWT------------------EEVPSCQVVKCSSLAVPGKINMSCSGEP 510 Query: 1855 AVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1898 G+ F C G+ L+GS A C + W+ LPTC P Sbjct: 511 VFGTVCKFACPEGWTLNGSAARTC----GATGHWSGLLPTCEAP 550 Score = 34.7 bits (78), Expect = 1.8 Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 7/68 (10%) Query: 2192 NGFVI----GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CGGN 2246 NGFV F T +F+C G+ L+G +L C S NW++ P C+A+ C Sbjct: 250 NGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS--SGNWDNEKPTCKAVTCRAV 307 Query: 2247 ITAMNGTI 2254 NG++ Sbjct: 308 RQPQNGSV 315 Score = 32.7 bits (73), Expect = 6.8 Identities = 20/78 (25%), Positives = 31/78 (39%), Gaps = 6/78 (7%) Query: 154 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIIS 213 F G +SC G++L G +L C T WD P C A C + G++ Sbjct: 388 FRYGSSCEFSCEQGFVLKGSKRLQC----GPTGEWDNEKPTCEAV-RCDAVHQPPKGLVR 442 Query: 214 SPSFP-NEYHNNADCTWT 230 P E+ + C ++ Sbjct: 443 CAHSPIGEFTYKSSCAFS 460 >gi|148922949 complement component (3b/4b) receptor 1-like [Homo sapiens] Length = 569 Score = 202 bits (515), Expect = 4e-51 Identities = 149/496 (30%), Positives = 216/496 (43%), Gaps = 55/496 (11%) Query: 2679 TKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNK-IGTQTSY 2737 T + + C PGY G P SI CL N W+ ++ C+ SC P P NG + + Sbjct: 59 TYLNYECRPGYSGR-PFSIICLKNSVWTSAKDK--CKRKSCRNPPDPVNGMAHVIKDIQF 115 Query: 2738 GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQ---VIGE 2791 S ++C G+ L+GS+ C+ SG +W C CG+P I NG + E Sbjct: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175 Query: 2792 NYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PVSCGHPG- 2839 + Y V Y CN G F L+G C + WSG P C+ P C P Sbjct: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235 Query: 2840 -SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2898 + I + + F+ N+VV F C G+ M+GP+ +CQA +W P C V C P Sbjct: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPD 294 Query: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH- 2957 +++R + + NF+ G VFY C PGY L GS+ L C P G W P C + C Sbjct: 295 VLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353 Query: 2958 -PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDAT 3013 +P VL G+ V + C L G S+ C L G W+ S P C Sbjct: 354 LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE---R 410 Query: 3014 GTCGDPGTPGHGS-RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS---WTGRQPEC 3069 +C P P +G ++ S + Y+C TG+ L G C+ +G+ W+ + P C Sbjct: 411 KSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470 Query: 3070 KAVQCGNPGTTANGKVFRIDGT-----TFSSSVIYSC-------MEGYILSGPSVRQCT- 3116 + + C NP NG R GT + V Y+C M ++ ++R+ + Sbjct: 471 QQIFCPNPPAILNG---RHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527 Query: 3117 --ANGTWSGTLPNCTI 3130 NG WS P C + Sbjct: 528 PHGNGVWSSPAPRCEL 543 Score = 195 bits (496), Expect = 6e-49 Identities = 147/503 (29%), Positives = 206/503 (40%), Gaps = 50/503 (9%) Query: 2801 YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG-NGFNFNDVVTF 2859 Y+C PG+ S+ IC ++ W+ C SC +P P+ G F + + Sbjct: 63 YECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKY 121 Query: 2860 SCNIGYLMQGPTKAQCQANRQ---WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2916 SC GY + G + A C + W + P+C + C P AN S I F YG Sbjct: 122 SCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTS-ISREYFHYG 180 Query: 2917 TVVFYDCNPG------YFLFGSSVLICQPN----GQWDKPLPECIMID-CGHPGVPPNAV 2965 +VV Y CN G + L G + C G W P P+CI+ + C P V + Sbjct: 181 SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL 240 Query: 2966 LSGEK--YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPG 3023 +S + ++ V + C + G S CQ W P CS C P Sbjct: 241 VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR----VCQPPPDVL 296 Query: 3024 HGSRQE---SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN-PGT 3079 H R + NF V Y+C+ GY L GS C G W+ P C+ C + G Sbjct: 297 HAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQ 356 Query: 3080 TANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDP 3136 NG V + V + C EG+ L G S C G W+ ++P C SC P Sbjct: 357 LPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETP 416 Query: 3137 GIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVT 3192 +P NG+ + D VG ++Y C G+ L G C ++G WS P C+ + Sbjct: 417 PVPVNGMVHVITDIHVGSRINYSCTTGH--RLIGHSSAECILSGNTAHWSMKPPICQQIF 474 Query: 3193 CPTPPQISNGRLEGT---NFDWGFSISYICSPGYE--LSFPAVLTCV--------GNGTW 3239 CP PP I NGR GT + +G +SY C P + ++F + GNG W Sbjct: 475 CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVW 534 Query: 3240 SGEVPQC-LPKFCGDPGIPAQGK 3261 S P+C LP G GK Sbjct: 535 SSPAPRCELPVGAGSHDALIVGK 557 Score = 171 bits (433), Expect = 1e-41 Identities = 147/496 (29%), Positives = 204/496 (41%), Gaps = 51/496 (10%) Query: 2913 FTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK-Y 2971 F GT + Y+C PGY S+ IC N W +C C +P P N + K Sbjct: 55 FPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDI 113 Query: 2972 TFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPGHG--- 3025 F S + YSC L+G SS TC ++G+ W P C CG P T +G Sbjct: 114 QFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD---RIICGLPPTIANGDFT 170 Query: 3026 SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECKAVQCG 3075 S F S V Y C+ G + L G C + G W+G P+C Sbjct: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230 Query: 3076 NPGTTANGKVFRIDGTTFSSS--VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISC 3133 P NG + + + FS + V + C G+ + GPS +C A W LP+C+ + Sbjct: 231 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQ 290 Query: 3134 GDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3191 P + R D++ GQ V Y C+PGY +L GS CT G WS P C Sbjct: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY--DLRGSTYLHCTPQGDWSPAAPRCEVK 348 Query: 3192 TCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG---TWSGEVPQC 3246 +C Q+ NG L N G + ++C G++L + CV G W+ VP C Sbjct: 349 SCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408 Query: 3247 LPKFCGDPGIPAQGKREGKSFIY-QSEVSFSCNFPFILVGSSTRICQADGT---WSGSSP 3302 K C P +P G + I+ S +++SC L+G S+ C G WS P Sbjct: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPP 468 Query: 3303 HCIEPTQTSCENPGVPRHGSQNNT------FGFQVGSVVQFHCKKG---HLLQGST-TRT 3352 C Q C NP +G T +G +V H +G +L+ ST RT Sbjct: 469 IC---QQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRT 525 Query: 3353 CLP--DLTWSGIQPEC 3366 P + WS P C Sbjct: 526 SEPHGNGVWSSPAPRC 541 Score = 160 bits (405), Expect = 2e-38 Identities = 122/398 (30%), Positives = 166/398 (41%), Gaps = 30/398 (7%) Query: 3056 CLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQC 3115 CL N WT + +CK C NP NG I F S + YSC +GY L G S C Sbjct: 78 CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC 137 Query: 3116 TANGT---WSGTLPNCTIISCGDPGIPANG--LRYGDDYV-VGQNVSYMCQPG----YTM 3165 +G W P C I CG P ANG +Y G V+Y C G Sbjct: 138 IISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVF 197 Query: 3166 ELNGSRIRTCTIN----GTWSGVMPTCRAVTCPTPPQISNGRLEGTN---FDWGFSISYI 3218 EL G CT G WSG P C TPP + NG L N F + + Sbjct: 198 ELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 257 Query: 3219 CSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG---IPAQGKREGKSFIYQSEVSF 3275 C PG+ + P+ + C W E+P C + C P + +R+ +F EV + Sbjct: 258 CQPGFGMKGPSHVKCQALNKWEPELPSC-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 316 Query: 3276 SCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN-PGVPRHGSQNNTFGFQVGSV 3334 SC + L GS+ C G WS ++P C SC++ G +G Q+G+ Sbjct: 317 SCEPGYDLRGSTYLHCTPQGDWSPAAPRC---EVKSCDDFLGQLPNGHVLFPLNLQLGAK 373 Query: 3335 VQFHCKKGHLLQGSTTRTCL---PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHG 3391 V F C +G L+GS+ C+ + W+ P C SC+ P P + V + G Sbjct: 374 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG 433 Query: 3392 YTLIYTCQPGFFLAGGTEHRVCRSDNT--WTGKVPICE 3427 + Y+C G L G + S NT W+ K PIC+ Sbjct: 434 SRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQ 471 Score = 159 bits (403), Expect = 4e-38 Identities = 133/464 (28%), Positives = 193/464 (41%), Gaps = 60/464 (12%) Query: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 C P P +G Q S ++++C +G+RL+G SSA C S WD P C Sbjct: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISG-NTVIWDNKTPVCD 154 Query: 2589 AISCGIPKAPTNGGI--LTTDYL-VGTRVTYFCNDGYRLSSKELTTAV------CQSD-- 2637 I CG+P NG ++ +Y G+ VTY CN G R K++ V C S Sbjct: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSR--GKKVFELVGEPSIYCTSKDD 212 Query: 2638 --GTWSNHNKTPRCVV---VTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2692 G WS P+C++ T P++ + IL N S + V F C PG+ Sbjct: 213 QVGIWS--GPAPQCIIPNKCTPPNVENGILVSD-----NRSLFSLNEVVEFRCQPGFGMK 265 Query: 2693 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT-------SYGSTAIFTC 2745 GP+ ++C W E P SC + PP +T S G ++C Sbjct: 266 GPSHVKC--QALNKWEPELP-----SCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 318 Query: 2746 DLGFMLVGSAVRECLSSGLWSESETRCLAGHC-GIPELIVNGQVIGE-NYGYRDTVVYQC 2803 + G+ L GS C G WS + RC C + NG V+ N V + C Sbjct: 319 EPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVC 378 Query: 2804 NPGFRLIGSSVRIC---QQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG-NGFNFNDVVTF 2859 + GF+L GSS C + W+ +P C SC P P+ G + + + Sbjct: 379 DEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINY 438 Query: 2860 SCNIGYLMQGPTKAQCQAN---RQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2916 SC G+ + G + A+C + WS PP+C+ + C +P N R + G+ YG Sbjct: 439 SCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNG-RHTGTPLGDIPYG 497 Query: 2917 TVVFYDCNP------GYFLFGSSVL--ICQP--NGQWDKPLPEC 2950 V Y C+P + L G S + +P NG W P P C Sbjct: 498 KEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541 Score = 127 bits (319), Expect = 2e-28 Identities = 107/361 (29%), Positives = 142/361 (39%), Gaps = 40/361 (11%) Query: 3099 YSCMEGYILSG-PSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVS 3156 Y C GY SG P C N W+ C SC +P P NG+ + D + Sbjct: 63 YECRPGY--SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120 Query: 3157 YMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGTN---FD 3210 Y C GY L GS TC I+G W P C + C PP I+NG + F Sbjct: 121 YSCPKGY--RLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178 Query: 3211 WGFSISYICSPG------YELSFPAVLTCVGN----GTWSGEVPQCL-PKFCGDP----G 3255 +G ++Y C+ G +EL + C G WSG PQC+ P C P G Sbjct: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238 Query: 3256 IPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENP 3315 I R F V F C F + G S CQA W P C C+ P Sbjct: 239 ILVSDNRS--LFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC----SRVCQPP 292 Query: 3316 GVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ 3373 H +Q + F G V + C+ G+ L+GST C P WS P C SC Sbjct: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDD 352 Query: 3374 --PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICEAG 3429 + P + ++L G + + C GF L G + + ++ W VP+CE Sbjct: 353 FLGQLPNGHVLFPLNLQL-GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERK 411 Query: 3430 S 3430 S Sbjct: 412 S 412 Score = 124 bits (312), Expect = 1e-27 Identities = 133/530 (25%), Positives = 204/530 (38%), Gaps = 73/530 (13%) Query: 2529 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2584 C+ PE P + T + + + + C G+ G+ S +C K+S W + Sbjct: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTSAK 88 Query: 2585 PACQAISCGIPKAPTNG-GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2643 C+ SC P P NG + D +++ Y C GYRL T + S T Sbjct: 89 DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWD 147 Query: 2644 NKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHG------LGP 2694 NKTP C + C P+I +G + ++ ++ Y + V + C+ G G +G Sbjct: 148 NKTPVCDRIICGLPPTI-----ANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGE 202 Query: 2695 ASIECL--PNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGS---TAIFTCDLGF 2749 SI C + W P C I + P NG + S S F C GF Sbjct: 203 PSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 262 Query: 2750 MLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG---QVIGENYGYRDTVVYQCNPG 2806 + G + +C + W E E + C P +++ Q +N+ V Y C PG Sbjct: 263 GMKGPSHVKCQALNKW-EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG 321 Query: 2807 FRLIGSSVRICQQDHNWSGQLPSCVPVSC---------GHPGSPIYGRTSGNGFNFNDVV 2857 + L GS+ C +WS P C SC GH P+ V Sbjct: 322 YDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPL-------NLQLGAKV 374 Query: 2858 TFSCNIGYLMQGPTKAQC---QANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFT 2914 F C+ G+ ++G + + C W+ P+C+ +C P +P N + Sbjct: 375 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITD---IH 431 Query: 2915 YGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKPLPECIMIDCGHPGVPPNAVLSGE-- 2969 G+ + Y C G+ L G S C +G W P C I C +P N +G Sbjct: 432 VGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPL 491 Query: 2970 -KYTFGSTVHYSCTGKR------SLLGQSS--RTCQL--NGHWSGSQPHC 3008 +G V Y+C +L+G+S+ RT + NG WS P C Sbjct: 492 GDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541 Score = 113 bits (283), Expect = 3e-24 Identities = 88/304 (28%), Positives = 125/304 (41%), Gaps = 29/304 (9%) Query: 3148 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG- 3206 ++ +G ++Y C+PGY+ C N W+ C+ +C PP NG Sbjct: 54 EFPIGTYLNYECRPGYS---GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVI 110 Query: 3207 TNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKRE 3263 + + I Y C GY L + TC+ +G W + P C CG P A G Sbjct: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170 Query: 3264 GKS---FIYQSEVSFSCNF------PFILVGSSTRICQAD----GTWSGSSPHCIEPTQT 3310 S F Y S V++ CN F LVG + C + G WSG +P CI P + Sbjct: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK- 229 Query: 3311 SCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIP 3368 C P V +G +N F + VV+F C+ G ++G + C W P C Sbjct: 230 -CTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC-S 286 Query: 3369 HSCKQPETPAHANVVGMDLP--SHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3426 C+ P HA D S G + Y+C+PG+ L G T + C W+ P C Sbjct: 287 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST-YLHCTPQGDWSPAAPRC 345 Query: 3427 EAGS 3430 E S Sbjct: 346 EVKS 349 Score = 85.9 bits (211), Expect = 7e-16 Identities = 124/506 (24%), Positives = 183/506 (36%), Gaps = 96/506 (18%) Query: 2182 QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPLPRC 2239 +SC +P NG + D I + C GY LIG+S+ TC+ G + W++ P C Sbjct: 94 KSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153 Query: 2240 EAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY---- 2294 + + CG T NG S EY ++ G + F ++ IY Sbjct: 154 DRIICGLPPTIANGDFTS--ISREYFHYGSVVTYHCNLGSRGKKV-FELVGEPSIYCTSK 210 Query: 2295 -DFITVWDGPDQNS--------PQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVL 2345 D + +W GP P + + S++S + + + F G + Sbjct: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270 Query: 2346 SYHAYQL---------RVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAIL 2395 A RVCQPPP V +AE D D F G + Y C PG+ L G+ L Sbjct: 271 KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYL 330 Query: 2396 TCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCA-WSISVEKGY 2454 C + A P C+V + L G +L P NLQ+ A ++G+ Sbjct: 331 HCT--PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP------LNLQLGAKVDFVCDEGF 382 Query: 2455 NITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHG 2514 + G + VL + ++S+ + Sbjct: 383 QL-------------------KGSSASYCVLAGMESLWNSSVPVCERKS----------- 412 Query: 2515 NNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSS 2574 C TP P +G + T + S + ++C G RL+G SSA C S Sbjct: 413 --------------CETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSG 458 Query: 2575 YGYHAWDAPVPACQAISCGIPKAPTNG---GILTTDYLVGTRVTYFCND------GYRL- 2624 H W P CQ I C P A NG G D G V+Y C+ + L Sbjct: 459 NTAH-WSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLI 517 Query: 2625 -SSKELTTAVCQSDGTWSNHNKTPRC 2649 S T+ +G WS + PRC Sbjct: 518 GESTIRRTSEPHGNGVWS--SPAPRC 541 Score = 84.0 bits (206), Expect = 3e-15 Identities = 56/191 (29%), Positives = 94/191 (49%), Gaps = 15/191 (7%) Query: 2536 PHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIP 2595 P+G+++ QL + V + CD GF+L G S++ C + W++ VP C+ SC P Sbjct: 358 PNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM-ESLWNSSVPVCERKSCETP 416 Query: 2596 KAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHN-KTPRCVVVT 2653 P NG + + TD VG+R+ Y C G+RL ++A C G ++ + K P C + Sbjct: 417 PVPVNGMVHVITDIHVGSRINYSCTTGHRLIGH--SSAECILSGNTAHWSMKPPICQQIF 474 Query: 2654 CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDP------GYHGLGPASIE--CLPNGTW 2705 CP N + +GR Y +V ++CDP ++ +G ++I P+G Sbjct: 475 CP--NPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNG 532 Query: 2706 SWRNERPYCQI 2716 W + P C++ Sbjct: 533 VWSSPAPRCEL 543 Score = 67.4 bits (163), Expect = 2e-10 Identities = 97/432 (22%), Positives = 157/432 (36%), Gaps = 76/432 (17%) Query: 1658 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 R+SC +P + +NG + D + S + Y C GY L G S+ TCI+ + W+ P Sbjct: 93 RKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGN-TVIWDNKTP 151 Query: 1717 SC-HAPCGSRSTGSEG--TVLSPNYPKNYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLH 1772 C CG T + G T +S Y SV ++C K F + G+ + TS Sbjct: 152 VCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD 211 Query: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKG-FHFV 1826 D V ++ GP Q + + + + + +S + + F KG H Sbjct: 212 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK 271 Query: 1827 YQAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIR 1877 QA+ + CS V +P +R + F+ G V + C PGY L GS + Sbjct: 272 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLH 331 Query: 1878 CETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAG 1936 C W+ + P C + C L G + + P + L EG Sbjct: 332 C----TPQGDWSPAAPRCEVKSCDDFL----GQLPNGHVLFPLNLQLGAKVDFVCDEGFQ 383 Query: 1937 IQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS 1996 ++ S+ +SL +++ P S T P +N + + Sbjct: 384 LKGSSASYCVLAGMESL-----WNSSVPVCERKSCETPPVPVNGMVHVI----------- 427 Query: 1997 AAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPG 2055 + I +G R +++ C G+ L GHS C + G Sbjct: 428 -----------------------TDIHVGSR------INYSCTTGHRLIGHSSAECILSG 458 Query: 2056 PVRRWNYPIPIC 2067 W+ PIC Sbjct: 459 NTAHWSMKPPIC 470 Score = 58.2 bits (139), Expect = 2e-07 Identities = 107/470 (22%), Positives = 157/470 (33%), Gaps = 101/470 (21%) Query: 769 LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINARRFG-DNFQLGSSIS 817 L ++ SGR F+I + C +P P+N + Q S I Sbjct: 61 LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120 Query: 818 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-----GAP---CGGHFSAPSGVILSP 869 C +G+ + G+ + TCI+ V+W P C G P G F++ S Sbjct: 121 YSCPKGY-RLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHY 179 Query: 870 GWPGYYKDSLNCEW--VIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNG 927 G Y +L V E SI T + Q + PN +P NG Sbjct: 180 GSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPP-NVENG 238 Query: 928 TQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 974 L S + ++ L R GF + H + +N + C P Sbjct: 239 -----ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPP 293 Query: 975 IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 1031 +H R D FS G V +SC+ GY L L C WS P C+ D Sbjct: 294 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353 Query: 1032 RG--PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1089 G P+G +L +P +L VD +G Q Sbjct: 354 LGQLPNGHVL-------FPLNLQLGAKVDFVCDEGFQ----------------------- 383 Query: 1090 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1149 L GS + AG+ +N + + CE P +P Sbjct: 384 ------LKGSSASYCVLAGMESL-----------------WNSSVPVCERKSCETPPVPV 420 Query: 1150 YGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC 1197 G + + +G + +SC++G+RL G S C L G WS P C Sbjct: 421 NGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470 Score = 57.0 bits (136), Expect = 3e-07 Identities = 102/442 (23%), Positives = 157/442 (35%), Gaps = 59/442 (13%) Query: 1335 STIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSP---- 1389 S I Y C GY L GSS C+ +G WD P C G ++G S Sbjct: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176 Query: 1390 ---GYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEIS 1446 G Y NL + S+ + D D + +W GP ++ + + Sbjct: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD-----DQVGIWSGPAPQCIIPNKCT 231 Query: 1447 GSLIPEGIHSTLN--IVTIQFDTDFYISKSGFAIQFSSSV---------------ATACR 1489 + GI + N + ++ +F + GF ++ S V + C+ Sbjct: 232 PPNVENGILVSDNRSLFSLNEVVEFRC-QPGFGMKGPSHVKCQALNKWEPELPSCSRVCQ 290 Query: 1490 DPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546 P ++ R + D PG V + C+PGY+L+G + C + W P+ P C Sbjct: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD---WSPAAPRCEV 347 Query: 1547 PCGGNLTGS--SGFILSP-NFPHPYPHSRDCDWTITV---NADYVISLAFISF--SIEPN 1598 + G +G +L P N CD + +A Y + S S P Sbjct: 348 KSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 407 Query: 1599 YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMH-LAFRSDGSVSYTG--FHLEYKA 1655 + P + ++ D + RI S T H L S +G H K Sbjct: 408 CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKP 467 Query: 1656 KLRES--CFDPGNIMNGTRLGM---DYKLGSTVTYYCD------AGYVLQGYSTLTCIMG 1704 + + C +P I+NG G D G V+Y CD + L G ST+ Sbjct: 468 PICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527 Query: 1705 DDGRPGWNRALPSCHAPCGSRS 1726 G W+ P C P G+ S Sbjct: 528 PHGNGVWSSPAPRCELPVGAGS 549 Score = 53.1 bits (126), Expect = 5e-06 Identities = 106/477 (22%), Positives = 159/477 (33%), Gaps = 60/477 (12%) Query: 430 KFSILNEGGIKTASNLCPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQR 488 K S+ K C +P +P NG + D S +++SC + Y L G+ S TC Sbjct: 80 KNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC-I 138 Query: 489 IAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQ 548 I+ W + PVC CG +G FTS + + + + KV + Sbjct: 139 ISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFE 198 Query: 549 INFE-EFDLEIGYDTLTIGDGGE----VGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQT 603 + E D + I G + + T V G V D S + + Sbjct: 199 LVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 258 Query: 604 DESVGSVG------FKVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFEC 650 G G +N E E SC P + R+ D FS + + C Sbjct: 259 QPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 318 Query: 651 QFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSPDYPEGYGNNLNCI 708 + G++L G + C WS P C +F P G VL P L Sbjct: 319 EPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP-----LNLQLGAK 373 Query: 709 WTIISDPGSRIHLSFNDFDL--------ESQFDFLAVKDGDSPESPILG---TFTGAEVP 757 + D G ++ S + + S K ++P P+ G T V Sbjct: 374 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG 433 Query: 758 SHLT---SNSHILRLEFQADHSMSGRGFN------ITYNTFGHNECPDPGIPINARRFG- 807 S + + H L A+ +SG + I F CP+P +N R G Sbjct: 434 SRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIF----CPNPPAILNGRHTGT 489 Query: 808 --DNFQLGSSISVICEEG-----FIKTQGTETI-TCILMDGKVMWSGLIPKCGAPCG 856 + G +S C+ G TI G +WS P+C P G Sbjct: 490 PLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546 Score = 52.8 bits (125), Expect = 6e-06 Identities = 28/64 (43%), Positives = 35/64 (54%), Gaps = 2/64 (3%) Query: 134 QSSSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPV 192 + SC P VP G+++ T VG +I YSC TG+ L GH CI S NTA W Sbjct: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSMKP 467 Query: 193 PICR 196 PIC+ Sbjct: 468 PICQ 471 Score = 46.6 bits (109), Expect = 5e-04 Identities = 95/434 (21%), Positives = 144/434 (33%), Gaps = 90/434 (20%) Query: 969 SCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPLPTCD 1024 SC +P PV+G + D S + +SC GYRL C W + P CD Sbjct: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154 Query: 1025 AL-CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1083 + CG +G S F+ S+ + GK V F L Sbjct: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKV------FELVGEPSIYCT 208 Query: 1084 TENG-----SFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE---GFNITFS 1135 +++ S P + PP + G+ + L +++ + + GF + Sbjct: 209 SKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV-VEFRCQPGFGMKGP 267 Query: 1136 EY-------NLEP--------CEDPGIPQYGSRIGF---NFGIGDTLTFSCSSGYRLEGT 1177 + EP C+ P + R NF G + +SC GY L G+ Sbjct: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327 Query: 1178 SEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGK 1237 + + C G WS PRC + S + L N ++ + +Q G Sbjct: 328 TYLHCTPQGD--WSPAAPRCEVK-------------SCDDFLGQLPNGHVLFPLNLQLGA 372 Query: 1238 GINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEG 1297 ++ F +G LK G+S L+ + LW NS Sbjct: 373 KVD-----FVCDEGFQLK----------------GSSASYCVLAGMES-LW---NSSVPV 407 Query: 1298 TDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKC-M 1356 E CE P +P G GS I Y C G+ L G S +C + Sbjct: 408 C-----------ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECIL 456 Query: 1357 TGERRAWDYPLPSC 1370 +G W P C Sbjct: 457 SGNTAHWSMKPPIC 470 Score = 43.9 bits (102), Expect = 0.003 Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%) Query: 131 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 189 ++ + SC NP P G+ + + +I+YSC GY L G TCI S NT WD Sbjct: 89 DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWD 147 Query: 190 FPVPIC 195 P+C Sbjct: 148 NKTPVC 153 Score = 40.8 bits (94), Expect = 0.025 Identities = 104/467 (22%), Positives = 167/467 (35%), Gaps = 76/467 (16%) Query: 1838 CSSVPEPRFGR-RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1896 C + P+P G + + S + + C GY L GS + C N++ W++ P C Sbjct: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVI-WDNKTPVCD 154 Query: 1897 -VPCG-------GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH 1948 + CG G T G Y NL K V E G + + T Sbjct: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGK-KVFELVG---EPSIYCTSK 210 Query: 1949 NWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNST---------SNNLYLNFQSDISVSAAG 1999 + D + + G AP+ + T P++ N S N + F+ G Sbjct: 211 D-DQVGIWSGP---APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKG 266 Query: 2000 -FHLEYTAIG-----LDSCPEPQTPSSGI-------KIGDRYMVGDVVSFQCDQGYSLQG 2046 H++ A+ L SC P + + D + G V + C+ GY L+G Sbjct: 267 PSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326 Query: 2047 HSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIG 2106 +++ C P W+ P C + + DF G + P +P +L ++ Sbjct: 327 STYLHCTPQG--DWSPAAPRCEVK---SCDDFLGQL--PNGHVLFPLNLQLGAKVDFVCD 379 Query: 2107 FGVHLQFVNFSTETIHDYLEVRSGS--------SETSTV-----IGRLSGPQIPSSL-FS 2152 G L+ + S + + + S ET V + ++ + S + +S Sbjct: 380 EGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYS 439 Query: 2153 TTHETSLYFHSD----YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGN---DFTVGQT 2205 T L HS S N + + Q CP+P NG G D G+ Sbjct: 440 CTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKE 499 Query: 2206 ISFECFPG------YTLIGNSALTCLHGVSRN--WNHPLPRCEALCG 2244 +S+ C P + LIG S + N W+ P PRCE G Sbjct: 500 VSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546 Score = 40.4 bits (93), Expect = 0.033 Identities = 63/274 (22%), Positives = 101/274 (36%), Gaps = 30/274 (10%) Query: 1142 CEDPGIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRCVA 1199 C +P P G + + + + +SC GYRL G+S C+ G V W P C Sbjct: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDR 155 Query: 1200 E-CGASAT--NNEGILLSPNYPLNYEN--NHECIYSIQVQAGKGINISARTFHLAQGDVL 1254 CG T N + +S Y +Y + + C + + + + ++ D + Sbjct: 156 IICGLPPTIANGDFTSISREY-FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214 Query: 1255 KIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTE-GTDEGFQLVYTSF---- 1309 I+ G + T ++ L S + L+ N E GF + S Sbjct: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLF-SLNEVVEFRCQPGFGMKGPSHVKCQ 273 Query: 1310 -------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCM 1356 EL C P + D+ +F+ G + Y C PGY L GS+ L C Sbjct: 274 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCT 333 Query: 1357 TGERRAWDYPLPSCIAECGGRFKGE-SSGRILSP 1389 + W P C + F G+ +G +L P Sbjct: 334 --PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP 365 Score = 37.7 bits (86), Expect = 0.21 Identities = 67/302 (22%), Positives = 102/302 (33%), Gaps = 53/302 (17%) Query: 792 NECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 848 N+C P + N DN F L + C+ GF +G + C ++ W + Sbjct: 228 NKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGF-GMKGPSHVKCQALN---KWEPEL 282 Query: 849 PKCGAPCGGHFSAPSGVI-----------LSPGWPGYYKDS----LNCEWVIEAEPGHSI 893 P C C P V+ SPG +Y L + P Sbjct: 283 PSCSRVC----QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDW 338 Query: 894 KITFERFQTELNYDVLEVHDGPNLLSPL---LGSYNGTQVPQ-FLFSSSNFIYLLFTTDN 949 R + + D L ++L PL LG+ + F S+ Y + Sbjct: 339 SPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 398 Query: 950 SRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRL---SHE 1005 S N+ + SC P +PV+G + D +GS +++SC +G+RL S Sbjct: 399 SLWNSSVPV------CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSA 452 Query: 1006 EPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1065 E +L WS P C I P P T D+ +GK V Sbjct: 453 ECILSGNTAHWSMKPPICQ------------QIFCPNPPAILNGRHTGTPLGDIPYGKEV 500 Query: 1066 QF 1067 + Sbjct: 501 SY 502 Score = 37.0 bits (84), Expect = 0.36 Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 1/59 (1%) Query: 1487 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544 +CR+P P+NG + + + + C GY L G TCI N W PVC Sbjct: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153 Score = 33.9 bits (76), Expect = 3.0 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 4/80 (5%) Query: 2180 QLQSCPD-PRPFRNGFVIGN-DFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPL 2236 +++SC D NG V+ + +G + F C G+ L G+SA C L G+ WN + Sbjct: 346 EVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 405 Query: 2237 PRCE-ALCGGNITAMNGTIY 2255 P CE C +NG ++ Sbjct: 406 PVCERKSCETPPVPVNGMVH 425 Score = 32.3 bits (72), Expect = 8.9 Identities = 22/74 (29%), Positives = 27/74 (36%), Gaps = 11/74 (14%) Query: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184 E + SC PP VL+ R F G ++ YSC GY L G L C Sbjct: 279 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQ--- 335 Query: 185 TASWDFPVPICRAE 198 W P C + Sbjct: 336 -GDWSPAAPRCEVK 348 >gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo sapiens] Length = 986 Score = 199 bits (505), Expect = 5e-50 Identities = 166/645 (25%), Positives = 272/645 (42%), Gaps = 122/645 (18%) Query: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 563 CG +++ G SPN+P Y + C+W I V+ + + F+ F++E YD L Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493 Query: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623 + DG + T++ G PD I S SS++WL +D S+ GF VN+ + E + Sbjct: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550 Query: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683 C P G E + + C G+EL +K C C Sbjct: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593 Query: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 739 T G++ SP +P+ Y N NCIW +++ RI L F+ F+ E ++DF+ V+ Sbjct: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653 Query: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGI 799 G + +S + G F G+E P +TS + +R+EF++D+++S +GF + + +EC Sbjct: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS-DKDEC----- 707 Query: 800 PINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHF 859 S + C++ + T G+ C G V+ A C Sbjct: 708 --------------SKDNGGCQQDCVNTFGSYECQC--RSGFVLHDNKHDCKEAGCDHKV 751 Query: 860 SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF----QTELNYDVLEVHDGP 915 ++ SG I SP WP Y C W I + PGH +K+TF Q E YD LEV DG Sbjct: 752 TSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGR 811 Query: 916 NLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGI 975 + +P+LG + G++ P+ + ++ + ++L F +DNS GF+ Sbjct: 812 DAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQA----------------- 854 Query: 976 PVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPS 1035 H G V + SH + GD P Sbjct: 855 -------SHATECGGQVRADVKTKDLYSHAQ---------------------FGDNNYPG 886 Query: 1036 GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITENGSFTQ 1091 G ++C W + G GV+ F TF +E+ +DY+ + + T Sbjct: 887 G--------------VDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTA 932 Query: 1092 P-LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFS 1135 P L R GS P + + ++F SD +I+ +GF++ ++ Sbjct: 933 PRLGRYCGSGPPEEVYS---AGDSVLVKFHSDDTITKKGFHLRYT 974 Score = 196 bits (498), Expect = 4e-49 Identities = 134/452 (29%), Positives = 218/452 (48%), Gaps = 56/452 (12%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954 CGG + K G I SP YP+ Y + C+W+I V EG + + SF E + +D L+ Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494 Query: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 2014 DG ++ +G Y G P + STS+ L+L F SD S++ AGF + + +D C Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553 Query: 2015 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2072 P ++ + + S++C D GY L P +R C A CG Sbjct: 554 PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592 Query: 2073 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2128 G ++ +G I SPG+P YP + +C W + P + + LQF F TE +D++EVR Sbjct: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652 Query: 2129 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPR 2188 SG + S + G+ G + P + S + + F SD + +K+GF + + + + D Sbjct: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKD-- 710 Query: 2189 PFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNIT 2248 NG + + +C G+ L N H EA C +T Sbjct: 711 ---NGGCQQDCVNTFGSYECQCRSGFVLHDNK-----HDCK----------EAGCDHKVT 752 Query: 2249 AMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVL----QTEPIYDFITVWDGPD 2304 + +GTI SP +PD+YP+ ++C W + PG+ + + F + Q E YD + V+DG D Sbjct: 753 STSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRD 812 Query: 2305 QNSPQIGQFSGNTALESVYSTSNQILIKFHSD 2336 +P +G+F G+ E V +T +++ ++F+SD Sbjct: 813 AKAPVLGRFCGSKKPEPVLATGSRMFLRFYSD 844 Score = 192 bits (489), Expect = 4e-48 Identities = 174/648 (26%), Positives = 270/648 (41%), Gaps = 126/648 (19%) Query: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGD-----V 1253 A CG + G + SPNYP +Y + CI+ IQV G + ++ ++F + + D Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 1254 LKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313 L++ DG +++ L+G + G + STS++LWL+F SD GF + + E+ Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPD-DIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550 Query: 1314 CEDPGIPQFGYK-ISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1372 C P + ++ G + S C+PGY L +RR C A Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCS-----CDPGYEL--------APDKRR--------CEA 589 Query: 1373 ECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS----HDI 1428 CGG F + +G I SPG+P Y N C+W + +SLQF F+TE + +D Sbjct: 590 ACGG-FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648 Query: 1429 LRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATAC 1488 + V G + L + GS PE I S N + ++F +D +SK GF F S Sbjct: 649 VEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECS 708 Query: 1489 RDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1548 +D G N G + QC G+ L + + C + A C Sbjct: 709 KDNGGCQQDCVNTFG-----SYECQCRSGFVLH-DNKHDCKE---------------AGC 747 Query: 1549 GGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYI 1604 +T +SG I SPN+P YP ++C W I+ + + L F+ IE YD L + Sbjct: 748 DHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEV 807 Query: 1605 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1664 +DG D+ +P++G F SK PE + ++ + M L F SD SV GF + + Sbjct: 808 FDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATEC------- 860 Query: 1665 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS 1724 G ++ D K T Y A + GD+ PG Sbjct: 861 -----GGQVRADVK---TKDLYSHAQF------------GDNNYPG-------------- 886 Query: 1725 RSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL-----HDVVEVYD 1779 G +C + I + + V F F+ +D +E++D Sbjct: 887 --------------------GVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFD 926 Query: 1780 GPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827 G + L GS E + S+G+ + ++F S IT KGFH Y Sbjct: 927 GYDSTAPRLGRYCGSGPPEEV-YSAGDSVLVKFHSDDTITKKGFHLRY 973 Score = 184 bits (468), Expect = 1e-45 Identities = 145/465 (31%), Positives = 212/465 (45%), Gaps = 56/465 (12%) Query: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124 A CGG + G I SP +P +Y S C W I + GF V L F +F E +DY Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 2125 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2184 LEVR G SE+ST+IGR G + P + ST+ L F SD S NK GF + + ++ C Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551 Query: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244 RP R G T+G + C PGY L + RCEA CG Sbjct: 552 S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592 Query: 2245 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2300 G +T +NG+I SPG+P EYP ++C W + P I + F +TE YDF+ V Sbjct: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652 Query: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPP 2360 G +S G+F G+ E + S N + ++F SD T S ++ C Sbjct: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNG 712 Query: 2361 VPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANE 2420 + + +E QC GF L N + D C + Sbjct: 713 GCQQDCVNTFGSYEC------QCRSGFVLHDN-----------KHDCKEAGC------DH 749 Query: 2421 LRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITM-FVEF---FQTEKEFDVLQVYD 2476 ++G I SP +PD YP+ + C W+IS G+ + + F+E Q E +D L+V+D Sbjct: 750 KVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFD 809 Query: 2477 GPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR 2521 G + ++PVL G + + G +FL++ +D+ +KGF+ Sbjct: 810 GRDAKAPVLGRFCGS-KKPEPVLATGSRMFLRFYSDNSVQRKGFQ 853 Score = 182 bits (463), Expect = 4e-45 Identities = 142/478 (29%), Positives = 212/478 (44%), Gaps = 73/478 (15%) Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1601 A CGG++ G I SPN+P Y S+ C W I V+ + + L F SF IE + YD+ Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 1602 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1661 L + DG +S LIG + + P+ I+S+S+ + L F SDGS++ GF + + ++ E C Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551 Query: 1662 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 P R G + + +T+ Y CD GY L P R C Sbjct: 552 SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587 Query: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1774 A CG T G++ SP +PK Y NC++ + P ++ + QF FF+T +DV Sbjct: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647 Query: 1775 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1831 VEV G T S L GS E + S N + + F S ++ KGF HF Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVIT-SQYNNMRVEFKSDNTVSKKGFKAHFF----- 701 Query: 1832 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDS 1891 + +CS + N F S C G++LH D+ Sbjct: 702 -SDKDECSK-DNGGCQQDCVNTFG---SYECQCRSGFVLH------------------DN 738 Query: 1892 LPTCI-VPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN- 1949 C C +T GTI SP +P+ Y + C W I+ G +++ + E Sbjct: 739 KHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQP 798 Query: 1950 ---WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 2004 +D L+ +DG D AP LG + G+ P + +T + ++L F SD SV GF + Sbjct: 799 ECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH 856 Score = 166 bits (421), Expect = 3e-40 Identities = 132/466 (28%), Positives = 198/466 (42%), Gaps = 59/466 (12%) Query: 1720 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1774 A CG G + SPNYP +Y C++ I V + F V F F+ HD Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 1775 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1834 +EV DG ++ S+L+ G + + S+ +++ ++F S G I GF + Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551 Query: 1835 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894 S E R +G S C+PGY E P+ Sbjct: 552 SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586 Query: 1895 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1950 C CGG LTK G+I SPG+P+ Y N NC+W++ P I +Q F TE N + Sbjct: 587 CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646 Query: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010 D ++ G ++ G + G+ P ++ S NN+ + F+SD +VS GF + + D Sbjct: 647 DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS-DKD 705 Query: 2011 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2070 C + +G D QC G+ L + H C A Sbjct: 706 EC----SKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKH-DCKE--------------AG 746 Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDYLE 2126 C ++ SG I SP +P YPS +CTW I+ G V L F+ E+ +D+LE Sbjct: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806 Query: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGF 2172 V G + V+GR G + P + +T L F+SD S ++GF Sbjct: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGF 852 Score = 160 bits (406), Expect = 2e-38 Identities = 190/717 (26%), Positives = 294/717 (41%), Gaps = 132/717 (18%) Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255 ACG T++ S+G SSP +PN Y + C W I PG+ I L FT + YDY+ Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380 Query: 256 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311 E+ P G +P PI+S + L + F + SN +GF A Y+ Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE-------A 433 Query: 312 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTS 371 G++++ G I + P D S V I ++SE V +T ++ ++ + S Sbjct: 434 ICGGDVKK----DYGHIQSPNYPDDYRPSKVCIWRI-QVSEGFHVGLT-FQSFEIERHDS 487 Query: 372 --KDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSN 429 D L ++S+ R+ +K D KS +L+ Sbjct: 488 CAYDYLEVRDGHSESSTLIGRYC--------------GYEKPDDIKSTSSRLW------- 526 Query: 430 KFSILNEGGIKTAS---NLCPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAK 482 +++G I A N + E R G + +LGS + SCD Y L K Sbjct: 527 -LKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGS-YKCSCDPGYELAPDK 584 Query: 483 SITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVN 542 C+ CG L +G+ TSP +P +Y N C+W + A Sbjct: 585 R-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA-P 624 Query: 543 TNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDLIVSMSSQMW 598 T I + F+ F+ E G D D EV T L G F P++I S + M Sbjct: 625 TQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMR 682 Query: 599 LHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIG 658 + ++D +V GFK ++ + E D G G ++ D + +C+ GF L Sbjct: 683 VEFKSDNTVSKKGFKAHFFSDKDECSKDNG----GCQQ-DCVNTFGSYECQCRSGFVLHD 737 Query: 659 EKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSR 718 K C+E C T+ GT+ SP++P+ Y + C W I S PG R Sbjct: 738 NKH-DCKEAG------------CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHR 784 Query: 719 IHLSFNDFDLESQ----FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQAD 774 + L+F + D+ESQ +D L V DG ++P+LG F G++ P + + + L F +D Sbjct: 785 VKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSD 844 Query: 775 HSMSGRGFNITYNTFGHNECPDPGIPINA----------RRFGDNFQLGS---SISVICE 821 +S+ +GF ++ T EC G + A +FGDN G ++ E Sbjct: 845 NSVQRKGFQASHAT----EC---GGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAE 897 Query: 822 EGF-----IKTQGTETITCILMDGKVMWSG---LIPKCGAPCGGHFSAPSGVILSPG 870 EG+ +T E T D ++ G P+ G CG S P + S G Sbjct: 898 EGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCG---SGPPEEVYSAG 951 Score = 150 bits (379), Expect = 2e-35 Identities = 127/466 (27%), Positives = 200/466 (42%), Gaps = 60/466 (12%) Query: 853 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 908 A CGG G I SP +P Y+ S C W I+ G + +TF+ F+ E + YD Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 968 LEV DG + S L+G Y G + P + S+S+ ++L F +D S + GF VN + Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF-------AVNFF 545 Query: 969 SCLDP-GIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALC 1027 +D P G + + SCD GY L+ ++ C+A C Sbjct: 546 KEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDK--------------RRCEAAC 591 Query: 1028 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLI 1083 GG + +G+I SPG+P+ YP + NC W + + F F E + +D++ + Sbjct: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651 Query: 1084 TENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1142 + L + GS+ P I + Y N R + F SD ++S +GF F E Sbjct: 652 RSGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHFFSDKDECS 708 Query: 1143 EDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECG 1202 +D G Q F + C SG+ L C G C Sbjct: 709 KDNGGCQQDCVNTFG-----SYECQCRSGFVLHDNKH-DCKEAG--------------CD 748 Query: 1203 ASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-----DVLKIY 1257 T+ G + SPN+P Y + EC ++I G + ++ + D L+++ Sbjct: 749 HKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVF 808 Query: 1258 DGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQ 1303 DG+D +LG F G S + + +T ++++L F SD +GFQ Sbjct: 809 DGRDAKAPVLGRFCG-SKKPEPVLATGSRMFLRFYSDNSVQRKGFQ 853 Score = 145 bits (365), Expect = 9e-34 Identities = 133/479 (27%), Positives = 201/479 (41%), Gaps = 64/479 (13%) Query: 1024 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1079 +A+CGGDV+ G I SP YP+ Y S C W + V+ G V F +F +E H +D Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 1080 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138 YL + + S + L R G + P I + + R L+F+SD SI+ GF + F + Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547 Query: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 ++ C P R G + SC GY L RC Sbjct: 548 VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588 Query: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1255 A CG T G + SP +P Y N CI+ + I++ F DV K Sbjct: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648 Query: 1256 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313 + G + L G F G S + ++S N + +EF SD + +GF+ + S + Sbjct: 649 VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDEC 707 Query: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1373 +D G Q D + GS C G+ LH + + D+ + S Sbjct: 708 SKDNGGCQ-----QDCVNTFGSYECQ-CRSGFVLHDNK----HDCKEAGCDHKVTS---- 753 Query: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA----SHDIL 1429 +SG I SP +P Y + C W I PG+ V L F+ D E+ ++D L Sbjct: 754 --------TSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHL 805 Query: 1430 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATAC 1488 V+DG +L GS PE + +T + + ++F +D + + G F +S AT C Sbjct: 806 EVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKG----FQASHATEC 860 Score = 115 bits (287), Expect = 1e-24 Identities = 88/291 (30%), Positives = 126/291 (43%), Gaps = 38/291 (13%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CGG +K G I+SP +P Y C W I E + + FQSF +E YDYL Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139 + DGH + R G+ P + ST S L+ SD +++ GF V +++E+ S Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 N G + L + + SC GY L + R E Sbjct: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589 Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 255 ACGG + +G I+SP +P EY N +C W +VA ISL F F+ E KYD++ Sbjct: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649 Query: 256 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 E+ L G P I S N +R+ F +D+ +GF A + Sbjct: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700 Score = 113 bits (282), Expect = 4e-24 Identities = 77/291 (26%), Positives = 129/291 (44%), Gaps = 38/291 (13%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 80 CGG L LNG+I SPG+P YP NC W ++A + RI + F F E +YD++ Sbjct: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139 + G + + G P +TS + + SD VS GFK ++ + S Sbjct: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKD 710 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 N G V + C +G++L + C+ E Sbjct: 711 NGGCQQDCV------NTFGSYECQCRSGFVLHDNKH------------------DCK-EA 745 Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255 C + +SG I+SP++P++Y + +CTW I + PG + L F + +E + YD+L Sbjct: 746 GCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHL 805 Query: 256 EI----EGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 E+ + P G P P+++ + + L F +D++ + +GF A + Sbjct: 806 EVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH 856 Score = 100 bits (250), Expect = 2e-20 Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%) Query: 2240 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2295 EA+CGG++ G I SP YPD+Y + C W ++V G + + F + E YD Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2353 ++ V DG ++S IG++ G + + STS+++ +KF SD +GF V + ++ Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549 Query: 2354 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413 C P +CL +G+ +C G L D C+ Sbjct: 550 ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588 Query: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2469 C +L+ G I SPG+P YP + C W + Y I++ +FF+TE ++ Sbjct: 589 AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646 Query: 2470 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526 D ++V G S + G ITS + + +++ +D+ +KKGF+ + + Sbjct: 647 DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702 Score = 97.8 bits (242), Expect = 2e-19 Identities = 76/299 (25%), Positives = 134/299 (44%), Gaps = 68/299 (22%) Query: 498 DHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDL- 556 D++ CK C + SGT TSPN+P +Y S +C W I++ ++V ++ F E D+ Sbjct: 737 DNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRV-KLTFMEMDIE 795 Query: 557 ---EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFK 613 E YD L + DG + P VL GS P+ +++ S+M+L +D SV GF+ Sbjct: 796 SQPECAYDHLEVFDGRDAKAP--VLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQ 853 Query: 614 VNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 673 ++ CG G ++ D +S+ QFG +NN Sbjct: 854 ASH----ATECG--GQVRADVKTKDLYSH-------AQFG------------DNN----- 883 Query: 674 IPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ-- 731 YP G ++C W I+++ G + L F F++E + Sbjct: 884 -----------------------YPGG----VDCEWVIVAEEGYGVELVFQTFEVEEETD 916 Query: 732 --FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 788 +D++ + DG +P LG + G+ P + S + ++F +D +++ +GF++ Y + Sbjct: 917 CGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTS 975 Score = 67.8 bits (164), Expect = 2e-10 Identities = 31/92 (33%), Positives = 52/92 (56%), Gaps = 4/92 (4%) Query: 1919 YDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLDFYDGGDNNAPRLGSYSGTTI 1974 Y ++C W I EG G+++ +F E +D ++ +DG D+ APRLG Y G+ Sbjct: 884 YPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGP 943 Query: 1975 PHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA 2006 P + S +++ + F SD +++ GFHL YT+ Sbjct: 944 PEEVYSAGDSVLVKFHSDDTITKKGFHLRYTS 975 Score = 66.6 bits (161), Expect = 4e-10 Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 4/97 (4%) Query: 2090 NYPSSLDCTWTINLPIGFGVHLQFVNFS----TETIHDYLEVRSGSSETSTVIGRLSGPQ 2145 NYP +DC W I G+GV L F F T+ +DY+E+ G T+ +GR G Sbjct: 883 NYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSG 942 Query: 2146 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQ 2182 P ++S + FHSD + K+GFH+ Y + + Q Sbjct: 943 PPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQ 979 Score = 65.9 bits (159), Expect = 7e-10 Identities = 37/110 (33%), Positives = 58/110 (52%), Gaps = 10/110 (9%) Query: 2243 CGGNITAMNGT--IYSPGY--PDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----Y 2294 CGG + A T +YS + YP DC W++ G G+ + F + E Y Sbjct: 860 CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGY 919 Query: 2295 DFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGF 2342 D++ ++DG D +P++G++ G+ E VYS + +L+KFHSD T GF Sbjct: 920 DYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGF 969 Score = 64.3 bits (155), Expect = 2e-09 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%) Query: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2293 L +C A CG + G SP YP+ Y C W + V PG I +NFT L Sbjct: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374 Query: 2294 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2345 YD++ V DG + +P G+F G+ E + ST +++ ++F S++ GFF + Sbjct: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430 Score = 63.2 bits (152), Expect = 5e-09 Identities = 33/90 (36%), Positives = 48/90 (53%), Gaps = 4/90 (4%) Query: 45 YPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLSLYDGHPHPTNFRTRLTGFHL 100 YP G +C WVI+AEE +++VFQ+F +EEE YDY+ L+DG+ R G Sbjct: 884 YPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGP 943 Query: 101 PPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 130 P V S ++ SD ++ GF + Y Sbjct: 944 PEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973 Score = 62.8 bits (151), Expect = 6e-09 Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%) Query: 451 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 498 EP+ + +G + S + ++ + Y + G K QR + Sbjct: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312 Query: 499 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 557 R + K CG LQ +G F+SP +P Y ++ CVW I+ K+I +NF DL Sbjct: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371 Query: 558 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 614 YD + + DG P + GS +P+ IVS S++W+ ++ + GF Sbjct: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429 Query: 615 NYKEIEKESCGDPGTPLYG 633 Y+ I CG YG Sbjct: 430 VYEAI----CGGDVKKDYG 444 Score = 62.4 bits (150), Expect = 8e-09 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%) Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603 CG L S+G SP +P+ Y C W I+V I L F S + + YD++ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1655 + DG +PL G F SKLPE I S+ + + + FRS + GF Y+A Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Score = 61.2 bits (147), Expect = 2e-08 Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954 CG L G SP YP Y +++CVW+I+V G I + S + +D ++ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2007 DG AP G + G+ +P + ST + L++ F+S + GF Y AI Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434 Score = 60.8 bits (146), Expect = 2e-08 Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%) Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2126 CG + D +G SP +P Y + + C W I++ G + L F + S +DY+E Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 VR G + + GR G ++P + ST + F S + +GF VY+A Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Score = 59.7 bits (143), Expect = 5e-08 Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%) Query: 2427 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2482 G I SP YPD Y ++C W I V +G+++ + + F+ E+ +D L+V DG + +S Sbjct: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502 Query: 2483 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2540 LI Y +I S ++L++ +D NK GF + + CS P G Sbjct: 503 STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559 Query: 2541 ISQTGGQLNSVVRWACDRGFRL 2562 + L S + +CD G+ L Sbjct: 560 EQRCLNTLGS-YKCSCDPGYEL 580 Score = 59.3 bits (142), Expect = 7e-08 Identities = 42/145 (28%), Positives = 63/145 (43%), Gaps = 8/145 (5%) Query: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253 E CGG ++ G I SP++P++Y + C W I G + L F F++E YD Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 254 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309 YLE+ SE T+ G P I S + L L FV+D + GF+ + Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551 Query: 310 HTTSTGELEEHNRTTTGAIAVASTP 334 + G E+ T G+ + P Sbjct: 552 SRPNRGGCEQRCLNTLGSYKCSCDP 576 Score = 58.5 bits (140), Expect = 1e-07 Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%) Query: 837 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 896 L G + + + KC A CG +G SP +P Y ++C W I PG I + Sbjct: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363 Query: 897 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 952 F + +++ L YD +EV DG +PL G + G+++P+ + S+ + +++ F + ++ Sbjct: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423 Query: 953 NNGFKIHYESV 963 GF YE++ Sbjct: 424 GKGFFAVYEAI 434 Score = 57.4 bits (137), Expect = 3e-07 Identities = 36/113 (31%), Positives = 46/113 (40%), Gaps = 4/113 (3%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CG TL+ G SP +P GY +C W I +I + F S L YDY+ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 133 + DG R R G LP P+ ST S + S GF YE + Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434 Score = 57.0 bits (136), Expect = 3e-07 Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%) Query: 1194 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1251 L +C A CG + ++ G SP YP Y + C++ I V G+ I ++ + L + Sbjct: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374 Query: 1252 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308 D +++ DG + L G F G+ + + ST ++LW+EF S + +GF VY + Sbjct: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Query: 1309 F-------ELSHCEDPGIP 1320 + H + P P Sbjct: 434 ICGGDVKKDYGHIQSPNYP 452 Score = 55.1 bits (131), Expect = 1e-06 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%) Query: 1713 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1769 R L C A CG S G SP YP YS +CV+ I+V P E ++ F +++ Sbjct: 314 RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372 Query: 1770 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827 L +D VEV DG +++ L GS E + +S+ +++ + F S KGF VY Sbjct: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431 Query: 1828 QAV 1830 +A+ Sbjct: 432 EAI 434 Score = 54.7 bits (130), Expect = 2e-06 Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%) Query: 1365 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1424 Y P+C G +S+G SP YP Y ++ C+W I V PG + L F + D Sbjct: 317 YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371 Query: 1425 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1478 S +D + V DG L GS +PE I ST + + ++F + ++ K FA+ Sbjct: 372 SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430 Score = 50.1 bits (118), Expect = 4e-05 Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 12/114 (10%) Query: 201 CGGTMRG---SSGIISSPSF-PNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----Y 252 CGG +R + + S F N Y DC W IVAE G + L+F F++EE+ Y Sbjct: 860 CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGY 919 Query: 253 DYLEI----EGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 DY+E+ + + P G P + S + + + F +D +GF Y Sbjct: 920 DYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973 Score = 49.3 bits (116), Expect = 7e-05 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 5/93 (5%) Query: 2436 DSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQSPVLISLSGD 2491 ++YP C W I E+GY + + + F+ E+E +D ++++DG + +P L G Sbjct: 882 NNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGS 941 Query: 2492 YSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2524 + S G V +++ +D KKGF +RY Sbjct: 942 -GPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973 Score = 45.4 bits (106), Expect = 0.001 Identities = 28/94 (29%), Positives = 48/94 (51%), Gaps = 6/94 (6%) Query: 1220 NYENNHECIYSIQVQAGKGINISARTFHLAQG-----DVLKIYDGKDKTTHLLGAFTGAS 1274 NY +C + I + G G+ + +TF + + D ++++DG D T LG + G+ Sbjct: 883 NYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSG 942 Query: 1275 MRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308 S+ + L ++F+SD T +GF L YTS Sbjct: 943 PPEEVYSAGDSVL-VKFHSDDTITKKGFHLRYTS 975 Score = 45.1 bits (105), Expect = 0.001 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%) Query: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1082 CG ++ +G SP YP Y ++C W + VT G+ + NF + L +DY+ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1083 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1120 + + PL R GS LP I ++ L+ FR+ ++ Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423 Score = 38.9 bits (89), Expect = 0.095 Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%) Query: 2416 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2470 CPA E DSTG SP YP+ Y C W ISV G I + + +D Sbjct: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378 Query: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530 ++V DG ++P+ G I S +++++ + KGF Y A C Sbjct: 379 YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436 Query: 2531 TPESPPHGYIIS 2542 +G+I S Sbjct: 437 GDVKKDYGHIQS 448 >gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 [Homo sapiens] Length = 809 Score = 194 bits (494), Expect = 1e-48 Identities = 153/558 (27%), Positives = 245/558 (43%), Gaps = 31/558 (5%) Query: 2178 AYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2237 AY L PRP +G V D G T +F C GY L G L CL+G +WN P Sbjct: 171 AYLLSCGFPPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETP 229 Query: 2238 RCEALCGGNI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDF 2296 C A CGG I A G I SP C W++ G ++++F + + D Sbjct: 230 SCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 289 Query: 2297 ITVWDGPDQNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRV 2354 + V G SP I + E + S + + ++ S+ + + L + A++ Sbjct: 290 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349 Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTL----VGNAILTCRLGERLQMDGAPP 2410 C P + + + T D E+ G + + CLPG+ L NAI C + P Sbjct: 350 CF-APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEP 407 Query: 2411 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2470 C+ +C EL + GV+LSP +P SY Q C W + V++ I + VE +E D Sbjct: 408 ACKAMC-GGELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGD 464 Query: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530 +L ++DG + VL L G + S+G ++ LQ+ A G G ++ + Sbjct: 465 MLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523 Query: 2531 TPES-------PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2581 P + PP + + G L +V+ + C+ G+ L+G C+ +W Sbjct: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWS 579 Query: 2582 APVPACQAI-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDG 2638 A PACQ I +C P NG +D + VG+ V Y C GY L + T + G Sbjct: 580 AAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 639 Query: 2639 TWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIE 2698 T ++ P+C + P +N + E+G ++ + HY+ + F C G+ +G +I Sbjct: 640 TPKWSDRVPKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 698 Query: 2699 CLPNGTWSWRNERPYCQI 2716 C+P W ++ P C++ Sbjct: 699 CVPGHPSQWTSQPPLCKV 716 Score = 192 bits (487), Expect = 7e-48 Identities = 168/681 (24%), Positives = 278/681 (40%), Gaps = 87/681 (12%) Query: 1481 SSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPS 1540 S + +C P P +G + PG T F CD GY+LQGEE + C+ R W Sbjct: 169 SPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGE 227 Query: 1541 PPVCIAPCGGNLTGSS-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1599 P C+A CGG + ++ G I+SP + C W I + L F S++ + Sbjct: 228 TPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 287 Query: 1600 DFLYIYDGPDSNSPLIGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLR 1658 D L + G SP+I +PER + S + ++++ S+ + L ++A Sbjct: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEE 347 Query: 1659 ESCFDP----GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGW 1711 + CF P GN+ T +Y+ G+ T+ C GY L+ + + C+ D P W Sbjct: 348 DRCFAPFLAHGNV---TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHW 402 Query: 1712 NRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL 1771 N P+C A CG + G VLSP++P++YS G +CV+ + V +E + Q Sbjct: 403 NDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE 462 Query: 1772 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVY 1827 D++ ++DG + +L+ L G L LSSG +T++F + P +GF + Sbjct: 463 GDMLTLFDGDGPSARVLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHF 521 Query: 1828 QAVPRTSSTQCSSVPEPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1885 + VPR + C +P P +G R + + G+ + + C PGY L GS + C Sbjct: 522 KEVPRNDT--CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC------- 572 Query: 1886 AQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SF 1944 QW+ S C I+T ++ G+ D P G+ +Q + + + Sbjct: 573 -QWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGY 623 Query: 1945 ATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 2004 + E A L YS D + Sbjct: 624 SLE--------------GAAMLTCYS--------------------RDTGTPKWSDRVPK 649 Query: 2005 TAIGLDSCPEPQTPSSGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNY 2062 A+ + C P P +G + Y G+ + F C +G+ L G ITC+PG +W Sbjct: 650 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTS 709 Query: 2063 PIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF------GVHLQFVNF 2116 P+C + + + P + I LP+G GV++ + Sbjct: 710 QPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKL 769 Query: 2117 STETIHDYLEVRSGSSETSTV 2137 +++ + SGS S + Sbjct: 770 QGKSLFGF----SGSHSYSPI 786 Score = 180 bits (456), Expect = 3e-44 Identities = 157/595 (26%), Positives = 249/595 (41%), Gaps = 74/595 (12%) Query: 969 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDAL 1026 SC P P HG D G T +F CDSGY+L EE L+C W+ P+C A Sbjct: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 234 Query: 1027 CGGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITE 1085 CGG + + G I+SP +L C W ++ G+ + +F L++ +D L++ Sbjct: 235 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRS 294 Query: 1086 NGSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCED 1144 GS P+ + SD+ GL + ++ + +S+ + ++ F + + C Sbjct: 295 GGSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFA 352 Query: 1145 PGIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAE 1200 P + + + G TFSC GY LE + I C+ W+ P C A Sbjct: 353 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 412 Query: 1201 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1260 CG + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG Sbjct: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGD 472 Query: 1261 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CE 1315 + +L G R LSS L L+F + G +GF L + + C Sbjct: 473 GPSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531 Query: 1316 DPGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IA 1372 + P++G++ + G G+ + Y C PGY L GS +L C +W P+C I Sbjct: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIM 589 Query: 1373 ECGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRV 1431 C + + R S G+P RC+ PG SL+ A T S D Sbjct: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT--- 638 Query: 1432 WDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDP 1491 P +D + K A+++ C +P Sbjct: 639 -GTPKWSDRVPK--------------------------------CALKYE-----PCLNP 660 Query: 1492 GVPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544 GVP NG T + G+++ F C G+EL GE ITC+ W PP+C Sbjct: 661 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 714 Score = 174 bits (440), Expect = 2e-42 Identities = 152/596 (25%), Positives = 233/596 (39%), Gaps = 73/596 (12%) Query: 2011 SCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2069 SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C+A Sbjct: 175 SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 233 Query: 2070 QCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVR 2128 CGG + + + G I+SP G +L C W I G +HL F S + +D L VR Sbjct: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293 Query: 2129 SGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDP 2187 SG S S VI +P L S + S+ N + ++A++ C P Sbjct: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353 Query: 2188 RPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCEAL 2242 +G V D + G +F C PGY L +A+ C+ +WN P C+A+ Sbjct: 354 F-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 412 Query: 2243 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2302 CGG ++ G + SP +P Y QDC W V V I + +L D +T++DG Sbjct: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLFDG 471 Query: 2303 PDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRVCQ 2356 ++ + Q G + S+ + ++F + GF + + C Sbjct: 472 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531 Query: 2357 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLC 2416 PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ Sbjct: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ--- 586 Query: 2417 PANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2476 + CA + G+ ++ F V Sbjct: 587 -----------------------KIMTCADPGEIANGHRTA-------SDAGFPV----- 611 Query: 2477 GPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CSTPE 2533 G ++Q Y + G + +S D G K R+ A C P Sbjct: 612 GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPG 661 Query: 2534 SPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 P +GY + + Q +R+ C GF L+G+ + C W + P C+ Sbjct: 662 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCK 715 Score = 161 bits (407), Expect = 1e-38 Identities = 145/598 (24%), Positives = 236/598 (39%), Gaps = 78/598 (13%) Query: 1838 CSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIV 1897 C P P G + G + F C+ GY L G + C + + WN P+C+ Sbjct: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSCMA 233 Query: 1898 PCGGILTKRK-GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFY 1956 CGG + G I+SP NL C W I EG + + + + + D L Sbjct: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293 Query: 1957 DGGDNNAPRLGSYSGTTIPHL-LNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEP 2015 GG +P + +P L S + +LY+ S+ + L + A D C P Sbjct: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353 Query: 2016 QTPSSGIKIGD-RYMVGDVVSFQCDQGYSLQ---GHSHITCMPGPVRRWNYPIPICLAQC 2071 + D Y G + +F C GY+L+ + I C+ WN P C A C Sbjct: 354 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 413 Query: 2072 GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGS 2131 GG +S+ +GV+LSP +P +Y DC W +++ + LQ V D L + G Sbjct: 414 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQ-VEILNVREGDMLTLFDGD 472 Query: 2132 SETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNK----QGFHIVY-QAYQLQSCPD 2186 ++ V+ +L GPQ L S+ + +L F + QGF + + + + +CP+ Sbjct: 473 GPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 532 Query: 2187 PRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-- 2242 P G+ + D G ++++C PGY L+G+ LTC +S W+ P C+ + Sbjct: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS--WSAAPPACQKIMT 590 Query: 2243 CG--GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300 C G I + T G+P G ++ + L P Y Sbjct: 591 CADPGEIANGHRTASDAGFP------------------VGSHVQYRCL---PGYSL---- 625 Query: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKF----HSDFTTSGFFVLSYHAYQLRVCQ 2356 + + + +S +T + +K+ + +G+ L H YQ Sbjct: 626 ----EGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ----- 676 Query: 2357 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414 G+ +R+ C GF L+G +TC G Q PP+C+V Sbjct: 677 ------------------AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716 Score = 155 bits (391), Expect = 9e-37 Identities = 115/438 (26%), Positives = 186/438 (42%), Gaps = 18/438 (4%) Query: 623 SCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFP 680 SCG P P +G F C G++L GE++++C + W+ P C+ Sbjct: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 234 Query: 681 CLSNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKD 739 C A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ Sbjct: 235 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRS 294 Query: 740 GDSPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPG 798 G SP SP++ +VP L S++ L +E ++ + ++ + F + C P Sbjct: 295 GGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF 354 Query: 799 IPI-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCG 856 + N ++ G+ + C G+ ++ G + + W+ P C A CG Sbjct: 355 LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCG 414 Query: 857 GHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPN 916 G S P+GV+LSP WP Y +C W + + I + E D+L + DG Sbjct: 415 GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDG 473 Query: 917 LLSPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLD 972 + +L G Q + L SS + L F N GF +H++ V N +C + Sbjct: 474 PSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPE 532 Query: 973 PGIPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG 1028 P G R D G+ +++ C+ GY L + L C+ + WS P C + C Sbjct: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA 592 Query: 1029 --GDVRGPSGTILSPGYP 1044 G++ T G+P Sbjct: 593 DPGEIANGHRTASDAGFP 610 Score = 148 bits (373), Expect = 1e-34 Identities = 122/456 (26%), Positives = 189/456 (41%), Gaps = 25/456 (5%) Query: 1311 LSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1370 L C P P G +S G T + C+ GY L G L C+ G R +W+ PSC Sbjct: 173 LLSCGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231 Query: 1371 IAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILR 1430 +A CGG + GRI+SP NL C W+IE G + L F + +D L Sbjct: 232 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 291 Query: 1431 VWDGPPENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1489 V G ++ + +PE G+ S + ++ ++ + +++F + C Sbjct: 292 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 351 Query: 1490 DPGVPM-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCI 1545 P + N T PG F C PGY L+ I C+ + W + P C Sbjct: 352 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACK 410 Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605 A CGG L+ +G +LSP++P Y +DC W + V + I L ++ D L ++ Sbjct: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLF 469 Query: 1606 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ES 1660 DG ++ ++ + + R+ SS + L F++ GF L +K R ++ Sbjct: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529 Query: 1661 C--FDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 C P T D G+ +TY C+ GY L G LTC W+ A P+C Sbjct: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 585 Query: 1719 H-----APCGSRSTGSEGTVLSPNYPKNYSVGHNCV 1749 A G + G T +P V + C+ Sbjct: 586 QKIMTCADPGEIANGHR-TASDAGFPVGSHVQYRCL 620 Score = 145 bits (367), Expect = 6e-34 Identities = 164/663 (24%), Positives = 249/663 (37%), Gaps = 86/663 (12%) Query: 1660 SCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH 1719 SC P +G D G T T++CD+GY LQG TL C+ G RP WN PSC Sbjct: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232 Query: 1720 APCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---HDVV 1775 A CG + G ++SP +VG N + F + SL +D + Sbjct: 233 ASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290 Query: 1776 EVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSS 1835 V G + S ++ E +S + + S P ++A Sbjct: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF---EE 347 Query: 1836 TQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQWND 1890 +C + P G E+ G+ F C PGY L AI C V + WND Sbjct: 348 DRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPHWND 404 Query: 1891 SLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNW 1950 + P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV Sbjct: 405 TEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNVREG 463 Query: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLEYTA 2006 D L +DG +A L G L S+ +L L FQ+ GF L + Sbjct: 464 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523 Query: 2007 IGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYP 2063 + D+CPE P G + + G V+++QC+ GY L G +TC W+ Sbjct: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAA 581 Query: 2064 IPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHD 2123 P C I++ PG + P+G H+Q+ ++ Sbjct: 582 PPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYSLEG 627 Query: 2124 YLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2183 + S +T T K + A + + Sbjct: 628 AAMLTCYSRDTGTP-------------------------------KWSDRVPKCALKYEP 656 Query: 2184 CPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC-- 2239 C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P C Sbjct: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716 Query: 2240 ---EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL---VRVPPGNGIYINFTVLQTEPI 2293 E L + T P E N L + + G+G+YI +T LQ + + Sbjct: 717 AYEELLDNRKLEVTQTT--DPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSL 774 Query: 2294 YDF 2296 + F Sbjct: 775 FGF 777 Score = 122 bits (307), Expect = 5e-27 Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%) Query: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505 C P P +G +D G T F CD Y LQG +++ C + +W+ P C + Sbjct: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 232 Query: 506 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 +CG + + G SP N C WVI A + + ++FE L+ D L Sbjct: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 291 Query: 565 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 620 + GG P V+ S + D+ ++S + +++ L ++ + + ++ E Sbjct: 292 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 346 Query: 621 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 674 ++ C P + D + + F C G+ L +I C + + W+ Sbjct: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406 Query: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 734 P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D Sbjct: 407 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 465 Query: 735 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 790 L + DGD P + +L G + L S+ L L+FQA + G+GF + + Sbjct: 466 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 525 Query: 791 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 847 N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS Sbjct: 526 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 581 Query: 848 IPKC 851 P C Sbjct: 582 PPAC 585 Score = 94.7 bits (234), Expect = 1e-18 Identities = 60/170 (35%), Positives = 83/170 (48%), Gaps = 15/170 (8%) Query: 3148 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV-TCPTPPQISNGRLEG 3206 D + G ++Y C+PGY EL GS I TC + +WS P C+ + TC P +I+NG Sbjct: 547 DLIRGTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA 604 Query: 3207 TN--FDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKF--CGDPGIPA 3258 ++ F G + Y C PGY L A+LTC G WS VP+C K+ C +PG+P Sbjct: 605 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664 Query: 3259 QGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQA--DGTWSGSSPHC 3304 G + YQ+ + F C F L+G T C W+ P C Sbjct: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714 Score = 88.2 bits (217), Expect = 1e-16 Identities = 61/189 (32%), Positives = 87/189 (46%), Gaps = 16/189 (8%) Query: 3015 TCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC-KA 3071 TC + P G R S+ + + Y C+ GY L GS+ TC + SW+ P C K Sbjct: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588 Query: 3072 VQCGNPGTTANGKVFRID-GTTFSSSVIYSCMEGYILSGPSVRQCTANGT----WSGTLP 3126 + C +PG ANG D G S V Y C+ GY L G ++ C + T WS +P Sbjct: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648 Query: 3127 NCTI--ISCGDPGIPANGLR--YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN--GT 3180 C + C +PG+P NG + Y Y G+++ + C G+ EL G TC Sbjct: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF--ELIGEVTITCVPGHPSQ 706 Query: 3181 WSGVMPTCR 3189 W+ P C+ Sbjct: 707 WTSQPPLCK 715 Score = 84.0 bits (206), Expect = 3e-15 Identities = 59/190 (31%), Positives = 81/190 (42%), Gaps = 12/190 (6%) Query: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951 N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C Sbjct: 527 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 586 Query: 2952 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3004 I C PG N S + GS V Y C SL G + TC WS Sbjct: 587 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 646 Query: 3005 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3060 P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+ Sbjct: 647 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705 Query: 3061 SWTGRQPECK 3070 WT + P CK Sbjct: 706 QWTSQPPLCK 715 Score = 83.2 bits (204), Expect = 4e-15 Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%) Query: 3192 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248 TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C Sbjct: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588 Query: 3249 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3302 C DPG A G R F S V + C + L G++ C + T WS P Sbjct: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648 Query: 3303 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3359 C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W Sbjct: 649 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 707 Query: 3360 SGIQPEC 3366 + P C Sbjct: 708 TSQPPLC 714 Score = 82.4 bits (202), Expect = 7e-15 Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%) Query: 2796 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2851 R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF Sbjct: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 609 Query: 2852 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2905 V + C GY ++G C + +WS P C K C +PG+P N + Sbjct: 610 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 669 Query: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2950 H + G + + C G+ L G + C P QW P C Sbjct: 670 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714 Score = 68.2 bits (165), Expect = 1e-10 Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 12/259 (4%) Query: 24 TCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82 +CGGT+ G I SP C WVI A E R+ + F+ +L+E+ D L + Sbjct: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293 Query: 83 DGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 G P + + + ++ +S++ + L S+ + + +E + C Sbjct: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRFEAFEEDRCFA 352 Query: 141 PGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTASWDFPVPICR 196 P + V + G +SC+ GY L+ G P + C+ W+ P C+ Sbjct: 353 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACK 410 Query: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE 256 A CGG + +G++ SP +P Y DC W + + I L + E Sbjct: 411 A--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 468 Query: 257 IEGSEPPTIWLSGMNIPPP 275 +G P L+ + P P Sbjct: 469 FDGDGPSARVLAQLRGPQP 487 Score = 67.8 bits (164), Expect = 2e-10 Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 15/188 (7%) Query: 2718 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC-LA 2774 +C ELP P G + + G+ + C+ G+ L+GS + C WS + C Sbjct: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588 Query: 2775 GHCGIPELIVNGQVIGENYGY--RDTVVYQCNPGFRLIGSSVRICQQ----DHNWSGQLP 2828 C P I NG + G+ V Y+C PG+ L G+++ C WS ++P Sbjct: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648 Query: 2829 SCV--PVSCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2882 C C +PG P G + + + + + F C G+ + G C QW+ Sbjct: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708 Query: 2883 HPPPMCKV 2890 PP+CKV Sbjct: 709 SQPPLCKV 716 Score = 60.5 bits (145), Expect = 3e-08 Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 10/161 (6%) Query: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 SCG P P G + T G + C +GY L G L C+ + SW+ P C Sbjct: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232 Query: 197 AEDACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYL 255 A +CGGT+ ++ G I SP N C W I A G + L F ++E D L Sbjct: 233 A--SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290 Query: 256 EI-EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 291 + G P P I+ S M+ P +IS+ L + ++++ Sbjct: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 331 Score = 57.0 bits (136), Expect = 3e-07 Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG Sbjct: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 471 Query: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 139 +L G + S+ +L+ + GF ++++E+ ++ +C Sbjct: 472 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531 Query: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 P G + D+ G + Y C GY L G LTC + SW P C+ Sbjct: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 587 Query: 198 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 227 C G + S FP H C Sbjct: 588 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 619 Score = 52.8 bits (125), Expect = 6e-06 Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%) Query: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C Sbjct: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650 Query: 504 KVK 506 +K Sbjct: 651 ALK 653 Score = 52.0 bits (123), Expect = 1e-05 Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%) Query: 3307 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3365 P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P Sbjct: 525 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 584 Query: 3366 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3418 C +C P A+ A+ G + SH + Y C PG+ L G C S +T Sbjct: 585 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 640 Query: 3419 --WTGKVPIC 3426 W+ +VP C Sbjct: 641 PKWSDRVPKC 650 Score = 51.6 bits (122), Expect = 1e-05 Identities = 31/77 (40%), Positives = 37/77 (48%), Gaps = 7/77 (9%) Query: 3015 TCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKA 3071 +CG P P HG ++ T + CD+GY L G E CL NG SW G P C A Sbjct: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA 233 Query: 3072 VQCGNPGTTANGKVFRI 3088 CG GT N + RI Sbjct: 234 -SCG--GTIHNATLGRI 247 Score = 44.3 bits (103), Expect = 0.002 Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%) Query: 137 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194 +C +PG G F VG ++Y C+ GY L+G LTC + T W VP Sbjct: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649 Query: 195 C 195 C Sbjct: 650 C 650 Score = 44.3 bits (103), Expect = 0.002 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%) Query: 133 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W Sbjct: 652 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 709 Query: 191 PVPICR 196 P+C+ Sbjct: 710 QPPLCK 715 Score = 43.9 bits (102), Expect = 0.003 Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 14/148 (9%) Query: 1659 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P Sbjct: 655 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 712 Query: 1717 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1776 C + V P G N +I +P V+ L V Sbjct: 713 LCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 763 Query: 1777 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1804 +Y Q SL SGSHS + + S Sbjct: 764 IYYTKLQGKSLF-GFSGSHSYSPITVES 790 Score = 43.1 bits (100), Expect = 0.005 Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 9/99 (9%) Query: 3161 PGYTMELNGSRIRTCTINGTWSGVMPTCRA----VTCPTPPQISNGRLEGTNFDWGFSIS 3216 PG + G T T T + V T + ++C PP+ ++G + T+ G + + Sbjct: 140 PGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTAT 199 Query: 3217 YICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCG 3252 + C GY+L L C+ NGT W+GE P C+ CG Sbjct: 200 FHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMAS-CG 236 Score = 41.2 bits (95), Expect = 0.019 Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%) Query: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773 ++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+ Sbjct: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232 Query: 2774 AGHCGIPELIVNGQVIGENYG 2794 A G G+++ G Sbjct: 233 ASCGGTIHNATLGRIVSPEPG 253 Score = 41.2 bits (95), Expect = 0.019 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%) Query: 619 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 674 ++ E C +PG P G + + + LRF C GFELIGE +I C +QW++ Sbjct: 652 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 711 Query: 675 PIC 677 P+C Sbjct: 712 PLC 714 Score = 40.4 bits (93), Expect = 0.033 Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%) Query: 3311 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3367 SC P P HG + T G FHC G+ LQG T CL +W+G P C+ Sbjct: 175 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232 Score = 38.5 bits (88), Expect = 0.12 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%) Query: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3186 ++SCG P PA+G D G ++ C GY +L G C +NGT W+G P Sbjct: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 229 Query: 3187 TCRAVTCPTPPQISNGRL 3204 +C A T + GR+ Sbjct: 230 SCMASCGGTIHNATLGRI 247 Score = 38.5 bits (88), Expect = 0.12 Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%) Query: 2777 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD--HNWSGQLPSCVPVS 2834 CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S Sbjct: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 234 Query: 2835 CG 2836 CG Sbjct: 235 CG 236 Score = 38.5 bits (88), Expect = 0.12 Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%) Query: 446 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C Sbjct: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 714 Query: 504 KV 505 KV Sbjct: 715 KV 716 Score = 35.8 bits (81), Expect = 0.80 Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%) Query: 2833 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2888 +SCG P P +G S + TF C+ GY +QG C W+ P C Sbjct: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231 Score = 34.7 bits (78), Expect = 1.8 Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 4/67 (5%) Query: 2952 MIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQPHC 3008 ++ CG P P + +S G T + C L G+ + C LNG W+G P C Sbjct: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231 Query: 3009 SGDATGT 3015 GT Sbjct: 232 MASCGGT 238 Score = 34.3 bits (77), Expect = 2.3 Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%) Query: 3370 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3427 SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C Sbjct: 175 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 232 Query: 3428 A 3428 A Sbjct: 233 A 233 Score = 34.3 bits (77), Expect = 2.3 Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Query: 3571 LNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVH 3628 L +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G + Sbjct: 727 LEVTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSY 783 Query: 3629 ENNNGQAAFENPMYD 3643 ++ F NP+Y+ Sbjct: 784 SPITVESDFSNPLYE 798 Score = 33.1 bits (74), Expect = 5.2 Identities = 16/38 (42%), Positives = 19/38 (50%), Gaps = 1/38 (2%) Query: 2683 FSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCG 2720 F CD GY G ++ CL SW E P C + SCG Sbjct: 200 FHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MASCG 236 >gi|62739186 complement factor H isoform a precursor [Homo sapiens] Length = 1231 Score = 193 bits (490), Expect = 3e-48 Identities = 234/902 (25%), Positives = 362/902 (40%), Gaps = 115/902 (12%) Query: 2587 CQAISCGIPKAPTNGGILTTD-----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2641 C A C N ILT Y GT+ Y C GYR + VC+ G W Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIM--VCRK-GEWV 72 Query: 2642 NHNKTPRCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI-E 2698 N +C C P F G + + G+ +EY K V++C+ GY LG + E Sbjct: 73 ALNPLRKCQKRPCGHPGDTPF----GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRE 128 Query: 2699 CLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGT------QTSYGSTAIFTCDLGFMLV 2752 C +G W N+ P C+++ C + P NG + + + +G F C+ G+ + Sbjct: 129 CDTDG---WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185 Query: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDT--VVYQCNPGFRLI 2810 G C G WS+ + +C+ C P+ ++NG I + Y++ Y+CN G+ Sbjct: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCNMGYEYS 244 Query: 2811 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSP--------IYGRTSGNGFNFNDVVTFSCN 2862 +C + W LPSC SC +P P I RT D +T+ C Sbjct: 245 ERGDAVCTES-GWR-PLPSCEEKSCDNPYIPNGDYSPLRIKHRT-------GDEITYQCR 295 Query: 2863 IGY--LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF--TYGTV 2918 G+ +G T A+C + W P P C + C P I + F G Sbjct: 296 NGFYPATRGNT-AKC-TSTGWI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKY 352 Query: 2919 VFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHP----GVPPNAVLSGEKY 2971 Y C+ + S + C +G W +P C+ C P G N G K+ Sbjct: 353 YSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR-KCYFPYLENGYNQN---HGRKF 406 Query: 2972 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTP---GHGSR 3027 G ++ +C G Q++ TC NG WS + P C TC G S Sbjct: 407 VQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRCI--RVKTCSKSSIDIENGFISE 462 Query: 3028 QESNFRTKSTVRYACDTGYILHGSEER---TCLANGSWTGRQPECKAVQCGNPGTTANGK 3084 + + K +Y C GY+ E TC +G W+ QP C C P N + Sbjct: 463 SQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-WSA-QPTC-IKSCDIP-VFMNAR 518 Query: 3085 VFRIDGTTF--SSSVIYSCMEGYILSGPSVR---QCTANGTWSGTLPNCTIISCGDPGIP 3139 + D T F + ++ Y C +GY + S C NG WS LP C C P I Sbjct: 519 T-KNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKID 575 Query: 3140 ANGL--RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR--AVTCPT 3195 + + R D Y VG+ + + C+PG+T + G C G S +P C+ +C Sbjct: 576 VHLVPDRKKDQYKVGEVLKFSCKPGFT--IVGPNSVQCYHFGL-SPDLPICKEQVQSCGP 632 Query: 3196 PPQISNGRL-EGTNFDWGFS--ISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKF 3250 PP++ NG + E T ++G S + Y C+P + + P + CV +G W+ +P C+ Sbjct: 633 PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWT-TLPVCIVEEST 690 Query: 3251 CGDPGIPAQGKREGKS--FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPT 3308 CGD G + S + Y V F+C+ F ++G + C G W+ P C+ Sbjct: 691 CGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT-QLPQCVAID 748 Query: 3309 Q-TSCENPG-VPRHGSQNNTFGFQVGSVVQFHC--KKGHLLQGSTTRTCLPDLTWSGIQP 3364 + C++ + N F S +++ C K+G + P++ S Q Sbjct: 749 KLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQI 808 Query: 3365 ECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVP 3424 + P P+ P N+ G + CQ + + G E + D W +P Sbjct: 809 QLCP---PPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE--ITCKDGRWQ-SIP 862 Query: 3425 IC 3426 +C Sbjct: 863 LC 864 Score = 180 bits (456), Expect = 3e-44 Identities = 235/915 (25%), Positives = 356/915 (38%), Gaps = 111/915 (12%) Query: 2554 WACDRGFRLVGKSSAVCRKSSYGYHAWDA--PVPACQAISCGIPKAPTNGGILTTD---Y 2608 + C G+R +G VCRK W A P+ CQ CG P G T + Sbjct: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104 Query: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWR 2668 G + Y CN+GY+L E+ C +DG W+ N P C VV C + + E+G + Sbjct: 105 EYGVKAVYTCNEGYQLLG-EINYRECDTDG-WT--NDIPICEVVKCLPVTA--PENG--K 156 Query: 2669 IVNGS-----HYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2723 IV+ + Y + V F C+ GY G + C +G WS E+P C ISC + P Sbjct: 157 IVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISC-KSP 213 Query: 2724 TPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPE 2781 NG+ I + Y F C++G+ C SG W + C C P Sbjct: 214 DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPS-CEEKSCDNP- 270 Query: 2782 LIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPG 2839 I NG +R D + YQC GF W P C C +P Sbjct: 271 YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDYPD 329 Query: 2840 SPIYGRTSGNGFNFNDVVTFSCNIG--YLMQGPTKAQCQANRQWSHPPPMCKVVNCS--- 2894 G N F +G Y + + W H ++C+ Sbjct: 330 IKHGGLYHENMRR----PYFPVAVGKYYSYYCDEHFETPSGSYWDH-------IHCTQDG 378 Query: 2895 -DPGIPANSK-------RESKIEHG-NFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWD 2944 P +P K HG F G + C+PGY L + + C NG W Sbjct: 379 WSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W- 436 Query: 2945 KPLPECIMI-DCGHPGVP-PNAVLSGEKYTFG--STVHYSC-TGKRSLLGQSSR--TCQL 2997 P P CI + C + N +S +YT+ Y C G + G++S TC Sbjct: 437 SPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGK 496 Query: 2998 NGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESN-FRTKSTVRYACDTGYILH-GSEERT 3055 +G WS +QP C +C P ++ + F+ T+ Y C GY + GS + Sbjct: 497 DG-WS-AQPTC----IKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGS 550 Query: 3056 CLANGSWTGRQPECKAVQCGNPGTTANGKVFR-IDGTTFSSSVIYSCMEGYILSGPSVRQ 3114 + + P C +C P + R D + +SC G+ + GP+ Q Sbjct: 551 IVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQ 610 Query: 3115 CTANGTWSGTLPNC--TIISCGDPGIPANG---LRYGDDYVVGQNVSYMCQPGYTMELNG 3169 C G S LP C + SCG P NG + ++Y + V Y C P + M+ G Sbjct: 611 CYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMK--G 667 Query: 3170 SRIRTCTINGTWSGVMPTC--RAVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYEL 3225 C ++G W+ +P C TC P++ +G +L + +G S+ + CS + + Sbjct: 668 PNKIQC-VDGEWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTM 725 Query: 3226 SFPAVLTCVGNGTWSGEVPQCLP----KFCGDPG--IPAQGKREGKSFIYQSEVSFSCNF 3279 +TC+ +G W+ ++PQC+ K C I + + K F + S + + C Sbjct: 726 IGHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRG 783 Query: 3280 PFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHC 3339 G +C +G W + Q P +P + T ++ G V C Sbjct: 784 K---EGWIHTVC-INGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLC 839 Query: 3340 KKGHLLQGSTTRTCLPDLTWSGIQPECIPH-SCKQPETPAHANV----VGMDLPSHGYTL 3394 ++ +L+Q TC D W I P C+ C QP H + + +HG L Sbjct: 840 QENYLIQEGEEITC-KDGRWQSI-PLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKL 897 Query: 3395 IYTCQPGFFLAGGTE 3409 YTC+ GF ++ E Sbjct: 898 SYTCEGGFRISEENE 912 Score = 178 bits (451), Expect = 1e-43 Identities = 192/691 (27%), Positives = 286/691 (41%), Gaps = 99/691 (14%) Query: 2547 QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAP-VPAC--QAISCGIPKAPTNGGI 2603 ++ V++++C GF +VG +S C YH +P +P C Q SCG P NG + Sbjct: 588 KVGEVLKFSCKPGFTIVGPNSVQC------YHFGLSPDLPICKEQVQSCGPPPELLNGNV 641 Query: 2604 ---LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVV--TCPSIN 2658 +Y V Y+CN + + V DG W+ P C+V TC I Sbjct: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV---DGEWTT---LPVCIVEESTCGDIP 695 Query: 2659 SFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIIS 2718 LEHG W ++ Y Y V F+C + +G SI C+ +G W+ + P C ++ Sbjct: 696 E--LEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT---QLPQC--VA 746 Query: 2719 CGELPTPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSA--VRECLSSGLWSESETRCLA 2774 +L + N I + + F ++ + G + +G W + E C Sbjct: 747 IDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRW-DPEVNCSM 805 Query: 2775 GH---CGIPELIVNGQVIGENYGYRD--TVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2829 C P I N + YRD V C + LI I +D W +P Sbjct: 806 AQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENY-LIQEGEEITCKDGRWQS-IPL 863 Query: 2830 CVP-VSCGHPGSPIYG-----RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSH 2883 CV + C P +G R+S + ++++C G+ + + C + WS Sbjct: 864 CVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK-WSS 922 Query: 2884 PPPMCKVVNCSDPGIPANSKRESKIEHG-------NFTYGTVVFYDCNPGYFLFGSSVLI 2936 PP C+ + C P +I HG ++ YG V Y C G+ + G ++ Sbjct: 923 PP-QCEGLPCKSP---------PEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAK 972 Query: 2937 CQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK---YTFGSTVHYSCTGKRSLLGQSSR 2993 C +W P P CI DC NA+ GEK Y G V Y+C + G S+ Sbjct: 973 CLGE-KWSHP-PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNV 1030 Query: 2994 TCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHG 3050 TC +N W+G +P C + C +P T + SRQ S + + VRY C + Y + G Sbjct: 1031 TC-INSRWTG-RPTCRDTS---CVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFG 1085 Query: 3051 SEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV--FRIDGTTFSSSVIYSCMEGYI 3106 EE CL NG+WT P+CK +CG P NG + F + +SSV Y C Y Sbjct: 1086 DEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 1143 Query: 3107 LSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN---GLRYGDDYVV----GQNVSYMC 3159 L G C NG WS P C I N LR+ + G++V ++C Sbjct: 1144 LEGNKRITC-RNGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVC 1201 Query: 3160 QPGYTMELNGSRIRTCTINGTWSGVM--PTC 3188 + GY + +RT W G + PTC Sbjct: 1202 KRGYRLSSRSHTLRTT----CWDGKLEYPTC 1228 Score = 173 bits (439), Expect = 2e-42 Identities = 250/946 (26%), Positives = 365/946 (38%), Gaps = 131/946 (13%) Query: 2529 CSTPESPPHGYIISQTGGQLNSVVR--WACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2586 C P P G G V+ + C+ G++L+G+ + W +P Sbjct: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTNDIPI 140 Query: 2587 CQAISCGIPKAPTNGGILTT------DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2640 C+ + C AP NG I+++ +Y G V + CN GY++ E C DG W Sbjct: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE--EMHCSDDGFW 198 Query: 2641 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH------YEYKTKVVFSCDPGYHGLGP 2694 S + P+CV ++C S + ++NGS Y+ + + C+ GY Sbjct: 199 S--KEKPKCVEISCKSPD----------VINGSPISQKIIYKENERFQYKCNMGYEYSER 246 Query: 2695 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFM-L 2751 C +G WR P C+ SC + P PNG+ + + G + C GF Sbjct: 247 GDAVCTESG---WR-PLPSCEEKSC-DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPA 301 Query: 2752 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENY--GYRDTVV-----YQCN 2804 +C S+G W + RC C P+ I +G + EN Y V Y C+ Sbjct: 302 TRGNTAKCTSTG-WIPA-PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCD 358 Query: 2805 PGFRLIGSSV---RICQQDHNWSGQLPSCVPVSCGHPG-SPIYGRTSGNGFNFNDVVTFS 2860 F S C QD WS +P C+ C P Y + G F + + Sbjct: 359 EHFETPSGSYWDHIHCTQD-GWSPAVP-CLR-KCYFPYLENGYNQNHGRKFVQGKSIDVA 415 Query: 2861 CNIGY-LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG--T 2917 C+ GY L + T C N WS P +V CS I + I +TY Sbjct: 416 CHPGYALPKAQTTVTCMEN-GWSPTPRCIRVKTCSKSSIDIEN---GFISESQYTYALKE 471 Query: 2918 VVFYDCNPGYFLFG---SSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGE--KYT 2972 Y C GY S + C +G W P CI C P V NA + + Sbjct: 472 KAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-PTCIK-SCDIP-VFMNARTKNDFTWFK 527 Query: 2973 FGSTVHYSC-TGKRSLLGQS--SRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGH--GSR 3027 T+ Y C G S G + S C NG WS P C C P H R Sbjct: 528 LNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPIC---YERECELPKIDVHLVPDR 582 Query: 3028 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV 3085 ++ ++ ++++C G+ + G C G + P CK CG P NG V Sbjct: 583 KKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICKEQVQSCGPPPELLNGNV 641 Query: 3086 FRIDGTTFSSS--VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTI--ISCGDPGIPAN 3141 + S V Y C +++ GP+ QC +G W+ TLP C + +CGD IP Sbjct: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWT-TLPVCIVEESTCGD--IPE- 696 Query: 3142 GLRYG------DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT 3195 L +G Y G +V + C +TM G R TC I+G W+ +P C A+ Sbjct: 697 -LEHGWAQLSSPPYYYGDSVEFNCSESFTM--IGHRSITC-IHGVWT-QLPQCVAIDKLK 751 Query: 3196 PPQISNGRL------EGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248 + SN + FD +I Y C G E V C+ NG W EV + Sbjct: 752 KCKSSNLIILEEHLKNKKEFDHNSNIRYRCR-GKEGWIHTV--CI-NGRWDPEVNCSMAQ 807 Query: 3249 -KFCGDPGIPAQGKREGKSFIYQ--SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3305 + C P + Y+ +VS C +++ C+ DG W S P C+ Sbjct: 808 IQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQ-SIPLCV 865 Query: 3306 EPTQTSCENPGVPRHGSQNNTFGFQV----GSVVQFHCKKGHLLQGSTTRTCLPDLTWSG 3361 E + C P HG+ N++ Q G+ + + C+ G + TC WS Sbjct: 866 E--KIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMG-KWSS 922 Query: 3362 IQPECIPHSCKQPETPAHANVVGM-DLPSHGYTLIYTCQPGFFLAG 3406 P+C CK P +H V M D +G + Y C GF + G Sbjct: 923 -PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDG 967 Score = 171 bits (433), Expect = 1e-41 Identities = 228/950 (24%), Positives = 384/950 (40%), Gaps = 125/950 (13%) Query: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGK-SSAVCRKSSYGYHAWDAPVPAC 2587 C P P Y + + + + C GF + ++A C + + P P C Sbjct: 267 CDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGW------IPAPRC 320 Query: 2588 QAISCGIPKAPTNGGILTTDY-------LVGTRVTYFCNDGYRLSSKELTTAV-CQSDGT 2639 C P +GG+ + VG +Y+C++ + S + C DG Sbjct: 321 TLKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG- 378 Query: 2640 WSNHNKTPRCVVVTCPSI-NSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYH-GLGPASI 2697 WS P P + N + HGR + V G + +C PGY ++ Sbjct: 379 WSP--AVPCLRKCYFPYLENGYNQNHGR-KFVQGKSIDV------ACHPGYALPKAQTTV 429 Query: 2698 ECLPNGTWSWRNERPYC-QIISCGELPTP-PNGNKIGTQTSYG--STAIFTCDLGFMLVG 2753 C+ NG WS P C ++ +C + NG +Q +Y A + C LG++ Sbjct: 430 TCMENG-WS---PTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTAD 485 Query: 2754 SAVRECLSSGL--WSESETRCLAGHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRL 2809 ++ G WS T C+ C IP + +N + + ++ DT+ Y+C+ G+ Sbjct: 486 GETSGSITCGKDGWSAQPT-CIKS-CDIP-VFMNARTKNDFTWFKLNDTLDYECHDGYES 542 Query: 2810 -IGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIY--GRTSGNGFNFNDVVTFSCNIGYL 2866 GS+ +N LP C C P ++ + + +V+ FSC G+ Sbjct: 543 NTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFT 602 Query: 2867 MQGPTKAQCQANRQWSHPPPMCK--VVNCSDPG--IPANSKRESKIEHGNFTYGTVVFYD 2922 + GP QC + S P+CK V +C P + N K ++K E+G + VV Y Sbjct: 603 IVGPNSVQCY-HFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYG---HSEVVEYY 658 Query: 2923 CNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPN----AVLSGEKYTFGSTVH 2978 CNP + + G + + C +G+W LP CI+ + +P A LS Y +G +V Sbjct: 659 CNPRFLMKGPNKIQCV-DGEWTT-LPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVE 716 Query: 2979 YSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSG-DATGTCGDPGTP--GHGSRQESNFRTK 3035 ++C+ +++G S TC ++G W+ P C D C + + F Sbjct: 717 FNCSESFTMIGHRSITC-IHGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHN 774 Query: 3036 STVRYAC--DTGYILHGSEERTCLANGSWTGRQPECKAVQ---CGNPGTTANGKVFRIDG 3090 S +RY C G+I T NG W + C Q C P N Sbjct: 775 SNIRYRCRGKEGWI------HTVCINGRWDP-EVNCSMAQIQLCPPPPQIPNSHNMT--- 824 Query: 3091 TTFS----SSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTI-ISCGDP-----GIPA 3140 TT + V C E Y++ C +G W ++P C I C P G Sbjct: 825 TTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQ-SIPLCVEKIPCSQPPQIEHGTIN 882 Query: 3141 NGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQIS 3200 + + Y G +SY C+ G+ ++ TC + G WS P C + C +PP+IS Sbjct: 883 SSRSSQESYAHGTKLSYTCEGGF--RISEENETTCYM-GKWSSP-PQCEGLPCKSPPEIS 938 Query: 3201 NGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFC-----GD 3253 +G + ++ +G ++Y C G+ + PA+ C+G WS P C+ C + Sbjct: 939 HGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWS-HPPSCIKTDCLSLPSFE 996 Query: 3254 PGIPAQGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTS 3311 IP K++ +Y++ +V+++C + + G+S C + W+G P C TS Sbjct: 997 NAIPMGEKKD----VYKAGEQVTYTCATYYKMDGASNVTC-INSRWTG-RPTC---RDTS 1047 Query: 3312 CENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPH 3369 C NP ++ + G V++ C+ + + G CL + W+ P+C Sbjct: 1048 CVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWTE-PPQCKDS 1105 Query: 3370 S--CKQPETPAHANVVGMDLPSH--GYTLIYTCQPGFFLAGGTEHRVCRS 3415 + C P + ++ L + ++ Y CQ + G + CR+ Sbjct: 1106 TGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-NLYQLEGNKRITCRN 1154 Score = 149 bits (375), Expect = 7e-35 Identities = 156/580 (26%), Positives = 239/580 (41%), Gaps = 70/580 (12%) Query: 2887 MCKVVNCSDPGIPANSKRESKIEHGNF---TY--GTVVFYDCNPGYFLFGSSVLICQPNG 2941 +C +C++ +P +R ++I G++ TY GT Y C PGY G+ +++C+ G Sbjct: 15 ICVAEDCNE--LPP--RRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KG 69 Query: 2942 QWD--KPLPECIMIDCGHPGVPPNAVLS---GEKYTFGSTVHYSCTGKRSLLGQSS-RTC 2995 +W PL +C CGHPG P + G + +G Y+C LLG+ + R C Sbjct: 70 EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC 129 Query: 2996 QLNGHWSGSQPHCSGDATGTCGDPGTPGHGS------RQESNFRTKSTVRYACDTGYILH 3049 +G W+ P C C P +G + + VR+ C++GY + Sbjct: 130 DTDG-WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185 Query: 3050 GSEERTCLANGSWTGRQPECKAVQCGNP----GTTANGKVFRIDGTTFSSSVIYSCMEGY 3105 G EE C +G W+ +P+C + C +P G+ + K+ + F Y C GY Sbjct: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ----YKCNMGY 241 Query: 3106 ILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQP 3161 S CT +G W LP+C SC +P IP NG LR + G ++Y C+ Sbjct: 242 EYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI--KHRTGDEITYQCRN 296 Query: 3162 GYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF-------DWGFS 3214 G+ G+ + CT G W P C C P I +G L N G Sbjct: 297 GFYPATRGNTAK-CTSTG-WIPA-PRCTLKPCDY-PDIKHGGLYHENMRRPYFPVAVGKY 352 Query: 3215 ISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKSFIYQ 3270 SY C +E S+ + C +G WS VP CL K C P + + G+ F+ Sbjct: 353 YSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRK-CYFPYLENGYNQNHGRKFVQG 409 Query: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQ 3330 + +C+ + L + T + + WS +P CI S + + + + + Sbjct: 410 KSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISESQYTYA 468 Query: 3331 VGSVVQFHCKKGHLLQGSTTR---TCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDL 3387 + ++ CK G++ T TC D WS QP CI SC P Sbjct: 469 LKEKAKYQCKLGYVTADGETSGSITCGKD-GWSA-QPTCI-KSCDIPVFMNARTKNDFTW 525 Query: 3388 PSHGYTLIYTCQPGF-FLAGGTEHRVCRSDNTWTGKVPIC 3426 TL Y C G+ G T + N W+ +PIC Sbjct: 526 FKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWS-DLPIC 564 Score = 144 bits (362), Expect = 2e-33 Identities = 201/774 (25%), Positives = 295/774 (38%), Gaps = 94/774 (12%) Query: 2714 CQIISCGELPTPPN-----GNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2768 C C ELP N G+ G+ AI+ C G+ +G+ + C G W Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74 Query: 2769 ET--RCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGS-SVRICQQDHN 2822 +C CG P G G + Y VY CN G++L+G + R C D Sbjct: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-G 133 Query: 2823 WSGQLPSCVPVSCGHPGSPIYGRTSGNG------FNFNDVVTFSCNIGYLMQGPTKAQCQ 2876 W+ +P C V C +P G+ + ++F V F CN GY ++G + C Sbjct: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193 Query: 2877 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKI---EHGNFTYGTVVFYDCNPGYFLFGSS 2933 + WS P C ++C P + S KI E+ F Y CN GY Sbjct: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ------YKCNMGYEYSERG 247 Query: 2934 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSC-TGKRSLLGQ 2990 +C +G W +PLP C C +P + PN S K+ G + Y C G Sbjct: 248 DAVCTESG-W-RPLPSCEEKSCDNPYI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304 Query: 2991 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR-------TKSTVRYACD 3043 ++ C G W + P C+ C P HG N R Y CD Sbjct: 305 NTAKCTSTG-WIPA-PRCT---LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCD 358 Query: 3044 TGYILHGS---EERTCLANGSWTGRQP---ECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3097 + + C +G W+ P +C N +G+ F + G S+ Sbjct: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRKF-VQG----KSI 412 Query: 3098 IYSCMEGYIL-SGPSVRQCTANGTWSGTLPNC-TIISCGDPGIPANGLRYGDD---YVVG 3152 +C GY L + C NG WS T P C + +C I + Y + Sbjct: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVKTCSKSSIDIENGFISESQYTYALK 470 Query: 3153 QNVSYMCQPGY-TMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG--TNF 3209 + Y C+ GY T + S TC +G WS PTC + P N R + T F Sbjct: 471 EKAKYQCKLGYVTADGETSGSITCGKDG-WS-AQPTC--IKSCDIPVFMNARTKNDFTWF 526 Query: 3210 DWGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKS 3266 ++ Y C GYE S + C NG WS ++P C + C P I + K Sbjct: 527 KLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKIDVHLVPDRKK 584 Query: 3267 FIYQ--SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN 3324 Y+ + FSC F +VG ++ C G S P C E Q SC P +G+ Sbjct: 585 DQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQ-SCGPPPELLNGNVK 642 Query: 3325 NTFGFQVG--SVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETP-AHAN 3381 + G VV+++C L++G C+ D W+ + P CI + P Sbjct: 643 EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTTL-PVCIVEESTCGDIPELEHG 700 Query: 3382 VVGMDLPSHGY--TLIYTCQPGFFLAGGTEHR-VCRSDNTWTGKVPICEAGSKI 3432 + P + Y ++ + C F + G HR + WT ++P C A K+ Sbjct: 701 WAQLSSPPYYYGDSVEFNCSESFTMIG---HRSITCIHGVWT-QLPQCVAIDKL 750 Score = 139 bits (351), Expect = 4e-32 Identities = 177/729 (24%), Positives = 282/729 (38%), Gaps = 96/729 (13%) Query: 2547 QLNSVVRWACDRGFRLVGKS---SAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGI 2603 +LN + + C G+ S S VC GY+ W + +P C C +PK + Sbjct: 527 KLNDTLDYECHDGYESNTGSTTGSIVC-----GYNGW-SDLPICYERECELPKIDVH--- 577 Query: 2604 LTTD-----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCV--VVTCPS 2656 L D Y VG + + C G+ + + C G + P C V +C Sbjct: 578 LVPDRKKDQYKVGEVLKFSCKPGFTIVGPN--SVQCYHFGLSPD---LPICKEQVQSCGP 632 Query: 2657 INSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQI 2716 + +G + Y + V + C+P + GP I+C+ +G W+ P C + Sbjct: 633 PPELL--NGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWT---TLPVCIV 686 Query: 2717 --ISCGELPTPPNG--NKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC 2772 +CG++P +G YG + F C F ++G C+ G+W++ +C Sbjct: 687 EESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIH-GVWTQLP-QC 744 Query: 2773 LA----GHCGIPELIVNGQVIG--ENYGYRDTVVYQCNPGFRLIGSSVRIC-----QQDH 2821 +A C LI+ + + + + + + Y+C I + +C + Sbjct: 745 VAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHT---VCINGRWDPEV 801 Query: 2822 NWS-GQLPSCVPVSCGHPGSP-IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR 2879 N S Q+ C P P P + T+ + + V+ C YL+Q + C+ R Sbjct: 802 NCSMAQIQLCPPP----PQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGR 857 Query: 2880 QWSHPPPMCKVVNCSDPG-IPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQ 2938 W P + + CS P I + S+ ++ +GT + Y C G+ + + C Sbjct: 858 -WQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY 916 Query: 2939 PNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSCTGKRSLLGQSSRTCQ 2996 G+W P P+C + C P + V++ + Y +G V Y C + G + C Sbjct: 917 M-GKWSSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC- 973 Query: 2997 LNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTC 3056 L WS D G +++ ++ V Y C T Y + G+ TC Sbjct: 974 LGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDV-YKAGEQVTYTCATYYKMDGASNVTC 1032 Query: 3057 LANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSS--VIYSCMEGYILSGPSVRQ 3114 + N WTGR P C+ C NP T N + + + S V Y C Y + G Sbjct: 1033 I-NSRWTGR-PTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVM 1090 Query: 3115 CTANGTWSGTLPNC--TIISCGDPGIPANGLRYG---DDYVVGQNVSYMCQPGYTMELNG 3169 C NG W+ P C + CG P NG Y +V Y CQ Y +E G Sbjct: 1091 CL-NGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLE--G 1146 Query: 3170 SRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFD--W----------GFSISY 3217 ++ TC NG WS C P IS +E N W G S+ + Sbjct: 1147 NKRITCR-NGQWS------EPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEF 1199 Query: 3218 ICSPGYELS 3226 +C GY LS Sbjct: 1200 VCKRGYRLS 1208 Score = 94.0 bits (232), Expect = 2e-18 Identities = 132/590 (22%), Positives = 222/590 (37%), Gaps = 109/590 (18%) Query: 2351 QLRVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAP 2409 Q++ C PPP + N + + +E+ +++ Y C P F + G + C GE + Sbjct: 626 QVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTL---- 681 Query: 2410 PVCQV---LCPANELRLDSTGVILSPG--YPDS-----------------------YPNL 2441 PVC V C + SP Y DS + L Sbjct: 682 PVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQL 741 Query: 2442 QMCAWSISVE--KGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNIT 2499 C ++ K N+ + E + +KEFD S + G + Sbjct: 742 PQCVAIDKLKKCKSSNLIILEEHLKNKKEFD---------HNSNIRYRCRGKEGWIHTVC 792 Query: 2500 SNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQT----GGQLNSVVRWA 2555 NG +W + + ++ C P P+ + ++ T G+ SV+ Sbjct: 793 ING-----RWDPEVNCSMAQIQL------CPPPPQIPNSHNMTTTLNYRDGEKVSVL--- 838 Query: 2556 CDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC-QAISCGIPKAPTNGGILTT-----DYL 2609 C + + C+ W + +P C + I C P +G I ++ Y Sbjct: 839 CQENYLIQEGEEITCKDG-----RWQS-IPLCVEKIPCSQPPQIEHGTINSSRSSQESYA 892 Query: 2610 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTC---PSINSFILEHGR 2666 GT+++Y C G+R+S + TT G WS+ P+C + C P I+ ++ H Sbjct: 893 HGTKLSYTCEGGFRISEENETTCYM---GKWSS---PPQCEGLPCKSPPEISHGVVAH-- 944 Query: 2667 WRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPP 2726 Y+Y +V + C G+ GPA +CL WS P C C LP+ Sbjct: 945 ----MSDSYQYGEEVTYKCFEGFGIDGPAIAKCL-GEKWS---HPPSCIKTDCLSLPSFE 996 Query: 2727 NGNKIGTQTSY---GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELI 2783 N +G + G +TC + + G++ C++S W+ T C C P + Sbjct: 997 NAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTGRPT-CRDTSCVNPPTV 1054 Query: 2784 VNGQVIG---ENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS--CGHP 2838 N ++ Y + V YQC + + G +C + NW+ + P C + CG P Sbjct: 1055 QNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGNWT-EPPQCKDSTGKCGPP 1112 Query: 2839 GSPIYGRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP 2885 G + + + V + C Y ++G + C+ N QWS PP Sbjct: 1113 PPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEPP 1161 Score = 53.5 bits (127), Expect = 4e-06 Identities = 81/384 (21%), Positives = 135/384 (35%), Gaps = 47/384 (12%) Query: 2351 QLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2410 Q+++C PPP +PN+ +T + G+ + C + + +TC+ G + P Sbjct: 807 QIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSI----P 862 Query: 2411 VCQVLCPANELRLDSTGVILS-----PGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQT 2465 +C P ++ G I S Y C + + T ++ + + Sbjct: 863 LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSS 922 Query: 2466 EKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVF------------LQWSADH 2513 + + L P I V+ +S Y +T E F +WS Sbjct: 923 PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPP 982 Query: 2514 GNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKS 2573 K + +F + P + + G Q V + C +++ G S+ C S Sbjct: 983 SCIKTDC-LSLPSFENAIPMGEKKD--VYKAGEQ----VTYTCATYYKMDGASNVTCINS 1035 Query: 2574 SYGYHAWDAPVPACQAISCGIPKAPTNGGILT---TDYLVGTRVTYFCNDGYRLSSKELT 2630 + P C+ SC P N I++ + Y G RV Y C Y + E Sbjct: 1036 RW------TGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDE-- 1087 Query: 2631 TAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYH 2690 V +G W+ + P+C T +++G S Y + V + C Y Sbjct: 1088 -EVMCLNGNWT---EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 1143 Query: 2691 GLGPASIECLPNGTWSWRNERPYC 2714 G I C NG WS E P C Sbjct: 1144 LEGNKRITC-RNGQWS---EPPKC 1163 Score = 49.3 bits (116), Expect = 7e-05 Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%) Query: 3332 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP--ECIPHSCKQP-ETPAHA-NVVGMDL 3387 G+ + C+ G+ G+ C W + P +C C P +TP + G ++ Sbjct: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103 Query: 3388 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3437 +G +YTC G+ L G +R C +D WT +PICE + V P Sbjct: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152 Score = 45.8 bits (107), Expect = 8e-04 Identities = 156/833 (18%), Positives = 275/833 (33%), Gaps = 157/833 (18%) Query: 1496 NGTRNGDGRE--PGDTVVFQCDPGYEL-QGEERITCIQVENRYFWQPSPP-VCIAPCG-G 1550 NG GR+ G ++ C PGY L + + +TC+ EN W P+P + + C Sbjct: 396 NGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCM--ENG--WSPTPRCIRVKTCSKS 451 Query: 1551 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1610 ++ +GFI + + + A Y L +++ DG S Sbjct: 452 SIDIENGFISESQYTY----------ALKEKAKYQCKLGYVTA------------DGETS 489 Query: 1611 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNG 1670 S G S P I+S + + R+ ++ Sbjct: 490 GSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTW------------------------ 525 Query: 1671 TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSE 1730 +KL T+ Y C GY ST I+ G GW+ LP C+ Sbjct: 526 ------FKLNDTLDYECHDGYESNTGSTTGSIVC--GYNGWSD-LPICYER--ECELPKI 574 Query: 1731 GTVLSPNYPKN-YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLS 1789 L P+ K+ Y VG +S V + L + + Q Sbjct: 575 DVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPP 634 Query: 1790 SLSGSHSGESLPLSSGNQITI------RFTSVGPITAKGFHFVYQAVPR--TSSTQCSSV 1841 L + E G+ + RF GP + + +P + C + Sbjct: 635 ELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDI 694 Query: 1842 PEPRFG--RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1899 PE G + + G SV F+C+ + + G +I C W LP C+ Sbjct: 695 PELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIH-----GVWTQ-LPQCVAID 748 Query: 1900 GGILTKRKGTILSPGY---PEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFY 1956 K I+ + + +D+N N ++ EG + + WD Sbjct: 749 KLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEG-----WIHTVCINGRWDP---- 799 Query: 1957 DGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAA----------------GF 2000 + N P + NS + LN++ VS Sbjct: 800 ---EVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDG 856 Query: 2001 HLEYTAIGLDSCPEPQTP-------SSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCM 2053 + + ++ P Q P +S + Y G +S+ C+ G+ + + TC Sbjct: 857 RWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY 916 Query: 2054 PGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQF 2113 G +W+ P C GV+ Y + T GFG+ Sbjct: 917 MG---KWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEV----TYKCFEGFGIDGPA 969 Query: 2114 VN--FSTETIHDYLEVRSG-----SSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYS 2166 + + H +++ S E + +G + + T+ + Y+ D + Sbjct: 970 IAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKK--DVYKAGEQVTYTCATYYKMDGA 1027 Query: 2167 QNKQGFHIVYQAYQL---QSCPDPRPFRNGFVIGND---FTVGQTISFECFPGYTLIGNS 2220 N + + SC +P +N +++ + G+ + ++C Y + G+ Sbjct: 1028 SNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDE 1087 Query: 2221 ALTCLHGVSRNWNHPLPRCE---ALCG-------GNITAMNGTIYSPGYPDEY 2263 + CL+G NW P P+C+ CG G+IT+ ++Y+P EY Sbjct: 1088 EVMCLNG---NWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 1136 Score = 42.7 bits (99), Expect = 0.007 Identities = 64/306 (20%), Positives = 108/306 (35%), Gaps = 37/306 (12%) Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVC-Q 2413 C+ PP + + + D ++ G+ + Y+C GF + G AI C LGE+ PP C + Sbjct: 931 CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKW---SHPPSCIK 986 Query: 2414 VLCPA-----NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE 2468 C + N + + + G +Y CA ++ N+T + Sbjct: 987 TDCLSLPSFENAIPMGEKKDVYKAGEQVTY----TCATYYKMDGASNVTCINSRWTGRPT 1042 Query: 2469 FDVLQVYDGPNIQSPVLISLS-GDYSSAFNITSNGHEVFLQWSAD-----HGNNKKGFRI 2522 + P +Q+ ++S Y S + + + + +GN + + Sbjct: 1043 CRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQC 1102 Query: 2523 RYIAFYCSTPESPPHGYIIS--QTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW 2580 + C P +G I S + S V + C ++L G CR W Sbjct: 1103 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQ-----W 1157 Query: 2581 DAPVPACQAISCGIPKAPTNGGILTTDYL--------VGTRVTYFCNDGYRLSSKELTTA 2632 P P C C I + + + G V + C GYRLSS+ T Sbjct: 1158 SEP-PKC-LHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLR 1215 Query: 2633 VCQSDG 2638 DG Sbjct: 1216 TTCWDG 1221 Score = 42.4 bits (98), Expect = 0.009 Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 14/156 (8%) Query: 134 QSSSCGNPGVPPKGVLY---GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 Q CG+PG P G G F+ G K Y+C GY L G +T W Sbjct: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTN 136 Query: 191 PVPICRAEDACGGTMRGSSGIISSPSFPN-EYHNNAD----CTWTIVAEPGDTISLIFTD 245 +PIC T + I+SS P+ EYH C E + + Sbjct: 137 DIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDG 196 Query: 246 FQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKN 281 F +EK +EI P I +G I II +N Sbjct: 197 FWSKEKPKCVEISCKSPDVI--NGSPISQKIIYKEN 230 Score = 41.6 bits (96), Expect = 0.015 Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%) Query: 2355 CQPPPPVPNAEILT---EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2401 C PP N EILT D + G Y+C PG+ +GN I+ CR GE Sbjct: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70 Score = 39.7 bits (91), Expect = 0.056 Identities = 51/253 (20%), Positives = 98/253 (38%), Gaps = 37/253 (14%) Query: 2012 CPEPQTPSSGI--KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2069 C P S G+ + D Y G+ V+++C +G+ + G + C+ +W++P P C+ Sbjct: 931 CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLG---EKWSHP-PSCIK 986 Query: 2070 QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINL--PIGFGVHLQFVNF---STETIHDY 2124 ++ F I Y + T+T + ++ +N T D Sbjct: 987 TDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRDT 1046 Query: 2125 LEVRSGSSETSTVIGRL-----SGPQI------PSSLFSTTHETSLYFHSDYSQNKQGFH 2173 V + + + ++ R SG ++ P +F E + + ++++ Q Sbjct: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGD--EEVMCLNGNWTEPPQCKD 1104 Query: 2174 IVYQAYQLQSCPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSR 2230 C P P NG + +V ++ ++C Y L GN +TC +G Sbjct: 1105 ------STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG--- 1155 Query: 2231 NWNHPLPRCEALC 2243 W+ P P+C C Sbjct: 1156 QWSEP-PKCLHPC 1167 Score = 39.3 bits (90), Expect = 0.073 Identities = 54/246 (21%), Positives = 95/246 (38%), Gaps = 46/246 (18%) Query: 2197 GNDFTVGQTISFECFPGYTLI-GNSALTCLHGVSRNWNHPLPRC---EALCGGNITAMNG 2252 G F G++I C PGY L + +TC+ W+ P PRC + +I NG Sbjct: 403 GRKFVQGKSIDVACHPGYALPKAQTTVTCMEN---GWS-PTPRCIRVKTCSKSSIDIENG 458 Query: 2253 TIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQ 2312 I Y + ++ + + E DG I Sbjct: 459 FISESQYT----------YALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKS 508 Query: 2313 ------FSGNTALESVYSTSNQIL-IKFHSDF-----TTSGFFVLSYHAYQ-LRVC-QPP 2358 + T + + N L + H + +T+G V Y+ + L +C + Sbjct: 509 CDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERE 568 Query: 2359 PPVPNAEI-LTED---DEFEIGDIIRYQCLPGFTLVG-NAILTCRLG---------ERLQ 2404 +P ++ L D D++++G+++++ C PGFT+VG N++ G E++Q Sbjct: 569 CELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQ 628 Query: 2405 MDGAPP 2410 G PP Sbjct: 629 SCGPPP 634 Score = 38.5 bits (88), Expect = 0.12 Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 28/273 (10%) Query: 1791 LSGSHSGESLPLSSGNQITIR----FTSVGPITA---KGFHFVYQAVPRTSSTQCSSVPE 1843 L+GS S ++ P G Q + + S+G + KG + + C + Sbjct: 33 LTGSWSDQTYP--EGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGD 90 Query: 1844 PRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIR-CETVPNSLAQWNDSLPTC-IVP 1898 FG GN F G ++ CN GY L G I R C+T W + +P C +V Sbjct: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVK 145 Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1958 C + G I+S + + + G I+ ++ + S + Sbjct: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205 Query: 1959 GDNNAPRLGSYSGTTIPHLLNSTSNNLY---LNFQSDISVSAAGFHLEYTAIGLDSCPEP 2015 + + +G+ I + N + N + S E L SC E Sbjct: 206 VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265 Query: 2016 QTPSSGIKIGD------RYMVGDVVSFQCDQGY 2042 + I GD ++ GD +++QC G+ Sbjct: 266 SCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF 298 Score = 38.1 bits (87), Expect = 0.16 Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 10/95 (10%) Query: 617 KEIEKESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 673 ++ +K CG PG +G + G+ F + C G++L+GE + + + W+ + Sbjct: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137 Query: 674 IPIC-IFPCLSNFTAP-----MGTVLSPDYPEGYG 702 IPIC + CL TAP + + + PD +G Sbjct: 138 IPICEVVKCLP-VTAPENGKIVSSAMEPDREYHFG 171 Score = 38.1 bits (87), Expect = 0.16 Identities = 64/286 (22%), Positives = 105/286 (36%), Gaps = 54/286 (18%) Query: 965 VNTYSCLDPGIPVHG-----RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP 1019 V C P HG R ++ G+ +S++C+ G+R+S E C W S Sbjct: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSP- 923 Query: 1020 LPTCDAL-CGGDVRGPSGTI--LSPGYPEFYPNSLNCTWTVDVTHGKGVQFN-FHTFHLE 1075 P C+ L C G + +S Y +G+ V + F F ++ Sbjct: 924 -PQCEGLPCKSPPEISHGVVAHMSDSY----------------QYGEEVTYKCFEGFGID 966 Query: 1076 DHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGN----FRAQLRFISDFSISYE--- 1128 + E S + LP NA G ++A + + Y+ Sbjct: 967 GPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDG 1026 Query: 1129 GFNITF--SEYNLEP------CEDPGIPQYG---SRIGFNFGIGDTLTFSCSSGYRLEGT 1177 N+T S + P C +P Q SR + G+ + + C S Y + G Sbjct: 1027 ASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGD 1086 Query: 1178 SEIICLGGGRRVWSAPLPRC---VAECGASATNNEGILLSPNYPLN 1220 E++CL G W+ P P+C +CG + G + S +PL+ Sbjct: 1087 EEVMCLNGN---WTEP-PQCKDSTGKCGPPPPIDNGDITS--FPLS 1126 Score = 37.7 bits (86), Expect = 0.21 Identities = 82/379 (21%), Positives = 133/379 (35%), Gaps = 100/379 (26%) Query: 1044 PEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLA-RLTGSDLP 1102 P PNS N T T++ G+ V +L + + + + PL P Sbjct: 814 PPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQP 873 Query: 1103 PTINAGLYGNFRA-QLRFISDFSISYE---GFNITFSEYNLE----------------PC 1142 P I G + R+ Q + +SY GF I SE N PC Sbjct: 874 PQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRI--SEENETTCYMGKWSSPPQCEGLPC 931 Query: 1143 EDPGIPQYG--SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1200 + P +G + + ++ G+ +T+ C G+ ++G + CLG WS P P C+ Sbjct: 932 KSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLG---EKWSHP-PSCIKT 987 Query: 1201 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1260 S + E + P+ + + +Y +AG+ + + T++ DG Sbjct: 988 DCLSLPSFENAI-----PMGEKKD---VY----KAGEQVTYTCATYYK--------MDGA 1027 Query: 1261 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1320 T + +TG T TS C +P Sbjct: 1028 SNVTCINSRWTGRP----TCRDTS-----------------------------CVNPPTV 1054 Query: 1321 QFGYKISDQ--GHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRF 1378 Q Y +S Q + +G + Y C Y + G + C+ G W P P C Sbjct: 1055 QNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN---WTEP-PQC-------- 1102 Query: 1379 KGESSGRILSPGYPFPYDN 1397 +S+G+ G P P DN Sbjct: 1103 -KDSTGKC---GPPPPIDN 1117 Score = 37.4 bits (85), Expect = 0.28 Identities = 13/39 (33%), Positives = 22/39 (56%) Query: 985 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023 ++ G V F C+SGY++ +E + C + +WS P C Sbjct: 167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205 Score = 37.4 bits (85), Expect = 0.28 Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 2/41 (4%) Query: 1158 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 + G + F C+SGY++EG E+ C G WS P+CV Sbjct: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206 Score = 36.6 bits (83), Expect = 0.47 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%) Query: 1506 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1548 P +V +QC Y+L+G +RITC + W PP C+ PC Sbjct: 1130 PASSVEYQCQNLYQLEGNKRITCRNGQ----WS-EPPKCLHPC 1167 Score = 35.8 bits (81), Expect = 0.80 Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 30/234 (12%) Query: 1327 SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE-CGGRFKGESSGR 1385 SDQ + G+ IY C PGY G+ ++ C GE A + PL C CG Sbjct: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PLRKCQKRPCGHPGDTPFGTF 96 Query: 1386 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWD-------GPPEN 1438 L+ G F Y ++ ++ + + + DT+ + + + + PEN Sbjct: 97 TLTGGNVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEN 154 Query: 1439 DMLLKEISGSLIPEGIHSTLNIV--------TIQFDTDFYISKSGF-AIQFSSSVATACR 1489 K +S ++ P+ + V I+ D + + S GF + + V +C+ Sbjct: 155 G---KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211 Query: 1490 DPGVPMNGTRNGDG--REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1541 P V +NG+ + + ++C+ GYE C + W+P P Sbjct: 212 SPDV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLP 260 Score = 35.4 bits (80), Expect = 1.0 Identities = 83/422 (19%), Positives = 147/422 (34%), Gaps = 69/422 (16%) Query: 1161 GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLN 1220 GD++ F+CS + + G I C+ G VW+ LP+CVA + +++ + N Sbjct: 712 GDSVEFNCSESFTMIGHRSITCIHG---VWT-QLPQCVAIDKLKKCKSSNLIILEEHLKN 767 Query: 1221 ---YENNHECIYSIQVQAG------------KGINISARTFHLAQGDVLKIYDGKDKTTH 1265 +++N Y + + G +N S L +I + + TT Sbjct: 768 KKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPP-QIPNSHNMTTT 826 Query: 1266 LLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFG-- 1323 L +++ N L ++ + D +Q + E C P + G Sbjct: 827 L----NYRDGEKVSVLCQENYL-IQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTI 881 Query: 1324 --YKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGE 1381 + S + + G+ + Y C G+ + + C G+ W P P C Sbjct: 882 NSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK---WSSP-PQCEGLPCKSPPEI 937 Query: 1382 SSGRI--LSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP--- 1436 S G + +S Y + + +C +D I + W PP Sbjct: 938 SHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC------------LGEKWSHPPSCI 985 Query: 1437 ENDMLLKEISGSLIPEG----IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVA------- 1485 + D L + IP G ++ VT T + + + +S Sbjct: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRD 1045 Query: 1486 TACRDPGVPMNG---TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPP 1542 T+C +P N +R G+ V +QC YE+ G+E + C+ W PP Sbjct: 1046 TSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN----W-TEPP 1100 Query: 1543 VC 1544 C Sbjct: 1101 QC 1102 Score = 35.0 bits (79), Expect = 1.4 Identities = 19/64 (29%), Positives = 27/64 (42%), Gaps = 9/64 (14%) Query: 1488 CRDPGVPMNGTRNGDGREP------GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1541 C P NG EP G V F C+ GY+++G+E + C + FW Sbjct: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC---SDDGFWSKEK 202 Query: 1542 PVCI 1545 P C+ Sbjct: 203 PKCV 206 Score = 34.7 bits (78), Expect = 1.8 Identities = 55/256 (21%), Positives = 98/256 (38%), Gaps = 58/256 (22%) Query: 453 ENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKS-ITCQRIAEVFAAWSDHRPVCKVKTCG 509 ENG + G F G ++ +C Y L A++ +TC WS +VKTC Sbjct: 395 ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCME-----NGWSPTPRCIRVKTCS 449 Query: 510 -SNLQGPSGTFTSPNFPFQYDSNA--QCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 566 S++ +G + + + A QC ++ + D E ++T G Sbjct: 450 KSSIDIENGFISESQYTYALKEKAKYQC-------------KLGYVTADGETS-GSITCG 495 Query: 567 DGGEVGDPRTVLQVLTGSFVPDLIVSMSSQM-----WLHLQ--------------TDESV 607 G P + D+ V M+++ W L T + Sbjct: 496 KDGWSAQPTCIKSC-------DIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTT 548 Query: 608 GSVGFKVN-YKEIE---KESCGDPGTPLYGI--REGDGFSNRDVLRFECQFGFELIGEKS 661 GS+ N + ++ + C P ++ + R+ D + +VL+F C+ GF ++G S Sbjct: 549 GSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNS 608 Query: 662 IVCQENNQWSANIPIC 677 + C S ++PIC Sbjct: 609 VQCYHFG-LSPDLPIC 623 Score = 34.3 bits (77), Expect = 2.3 Identities = 58/272 (21%), Positives = 94/272 (34%), Gaps = 50/272 (18%) Query: 1830 VPRTSSTQCSSVPEPRFGRRIGN------EFAVGSSVLFDCNPGYILHGSIAIRCETVPN 1883 +P +C V P G+ + + E+ G +V F CN GY + G + C + Sbjct: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----S 193 Query: 1884 SLAQWNDSLPTCI-VPCGGILTKRKGTILSPGYPEP----YDNNLNCVWKITVPEGAGIQ 1938 W+ P C+ + C K + G P Y N +K + G Sbjct: 194 DDGFWSKEKPKCVEISC-------KSPDVINGSPISQKIIYKENERFQYKCNM--GYEYS 244 Query: 1939 VQVVSFATEHNWDSLDFYDGGDNNAPRL--GSYSGTTIPHLLNSTSNNLYLNFQSDISVS 1996 + + TE W L + + P + G YS I H T + + ++ + Sbjct: 245 ERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKH---RTGDEITYQCRNGFYPA 301 Query: 1997 AAGFHLEYTAIG--------LDSCPEPQTPSSGIKIGDR------YMVGDVVSFQCDQGY 2042 G + T+ G L C P G+ + VG S+ CD+ + Sbjct: 302 TRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHF 361 Query: 2043 SLQGHS---HITCMPGPVRRWNYPIPICLAQC 2071 S HI C W+ +P CL +C Sbjct: 362 ETPSGSYWDHIHCTQD---GWSPAVP-CLRKC 389 Score = 33.5 bits (75), Expect = 4.0 Identities = 99/480 (20%), Positives = 170/480 (35%), Gaps = 101/480 (21%) Query: 794 CPDPGIPINARRFGD--NFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851 CP P N+ N++ G +SV+C+E ++ +G E ITC DG+ W IP C Sbjct: 811 CPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE-ITC--KDGR--WQS-IPLC 864 Query: 852 --GAPCGGHFSAPSGVILSP-----GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTEL 904 PC G I S + K S CE + ++ + Sbjct: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPP 924 Query: 905 NYDVLEVHDGPNL----LSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSRSNN--GFK 957 + L P + ++ + SY G +V F F D G K Sbjct: 925 QCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEG-------FGIDGPAIAKCLGEK 977 Query: 958 IHYESVTVNTYSCL-----DPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEK 1012 + + T CL + IP+ ++ + G V+++C + Y++ + C Sbjct: 978 WSHPPSCIKT-DCLSLPSFENAIPMGEKK--DVYKAGEQVTYTCATYYKMDGASNVTCIN 1034 Query: 1013 NHWWSHPLPTC-DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHT 1071 + W P TC D C + I+S + YP+ G+ V++ + Sbjct: 1035 SRWTGRP--TCRDTSCVNPPTVQNAYIVSRQMSK-YPS------------GERVRYQCRS 1079 Query: 1072 FHLEDHHDYLLITENGSFTQP--LARLTGS-DLPPTINAGLYGNFRAQLRFISDFSISYE 1128 + E D ++ NG++T+P TG PP I+ G I+ F +S Sbjct: 1080 PY-EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNG----------DITSFPLSV- 1127 Query: 1129 GFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRR 1188 + ++ + C + Y+LEG I C G Sbjct: 1128 -----------------------------YAPASSVEYQCQNLYQLEGNKRITCRNG--- 1155 Query: 1189 VWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL 1248 WS P P+C+ C S E ++ + + S++ +G +S+R+ L Sbjct: 1156 QWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTL 1214 Score = 33.5 bits (75), Expect = 4.0 Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%) Query: 646 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 705 + ++CQ ++L G K I C+ N QWS P C+ PC V+S + E Y N+ Sbjct: 1134 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 1179 Query: 706 NCIWT 710 WT Sbjct: 1180 ALRWT 1184 Score = 32.7 bits (73), Expect = 6.8 Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 12/72 (16%) Query: 446 CPDPGEPENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C D E E+G + + G +V+F+C E + + G +SITC + W+ P C Sbjct: 691 CGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-----IHGVWT-QLPQC 744 Query: 504 ----KVKTCGSN 511 K+K C S+ Sbjct: 745 VAIDKLKKCKSS 756 Score = 32.3 bits (72), Expect = 8.9 Identities = 14/43 (32%), Positives = 23/43 (53%), Gaps = 4/43 (9%) Query: 1676 DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 +Y G V + C++GY ++G + C DDG W++ P C Sbjct: 167 EYHFGQAVRFVCNSGYKIEGDEEMHC--SDDG--FWSKEKPKC 205 >gi|4502503 complement component 4 binding protein, alpha chain precursor [Homo sapiens] Length = 597 Score = 176 bits (447), Expect = 3e-43 Identities = 138/510 (27%), Positives = 213/510 (41%), Gaps = 49/510 (9%) Query: 2591 SCGIPK-----APTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK 2645 +CG P AP + + T + GT + Y C GY + S T C SDG W + Sbjct: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY-VRSHSTQTLTCNSDGEWVYNTF 107 Query: 2646 TPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIEC-LPNGT 2704 C+ C L +G+ I + + +++ FSC G+ +G + C + + Sbjct: 108 ---CIYKRCRHPGE--LRNGQVEIK--TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160 Query: 2705 WSWRNERPYCQIISCGELPTPPNGNKIGTQT--SYGSTAIFTCDLGFMLVGSAVRECL-- 2760 W + P C+I+ C P NG G + +YG + ++CD F L+G A C Sbjct: 161 VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220 Query: 2761 --SSGLWSESETRCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGSSVR 2815 + G+W S C C P+ + +G+++ G Y Y+DT+V++C GF L GSSV Sbjct: 221 NETIGVWRPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVI 279 Query: 2816 ICQQDHNWSGQLPSCVPVSC------GHPGSPIYGR-TSGNGFNFNDVVTFSCNIGY--L 2866 C D W+ P+C P SC H Y R T + + V+ + C+ GY Sbjct: 280 HCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPT 339 Query: 2867 MQGPTKAQCQANRQWSHPPPMCKVVNCSDP----GIPANSKRESKIEHGNFTYGTVVFYD 2922 PT CQ N +W+ P C+ + C +P G ++ H + YG + + Sbjct: 340 TDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFS 398 Query: 2923 CNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYT-FGSTVHYSC 2981 C+ ICQ +G W P C I P + Y+ F + Y C Sbjct: 399 CHE----TSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454 Query: 2982 TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPG-TPGHGSRQESNFRTKSTVRY 3040 L+GQ+ +C + HWS P C C P G S + + V Sbjct: 455 DKGYILVGQAKLSCSYS-HWSAPAPQCK----ALCRKPELVNGRLSVDKDQYVEPENVTI 509 Query: 3041 ACDTGYILHGSEERTCLANGSWTGRQPECK 3070 CD+GY + G + TC N +W P+C+ Sbjct: 510 QCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539 Score = 161 bits (408), Expect = 1e-38 Identities = 140/518 (27%), Positives = 221/518 (42%), Gaps = 54/518 (10%) Query: 2892 NCSDPG-IPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS-VLICQPNGQWDKPLPE 2949 NC P + + + + F GT + Y C PGY S+ L C +G+W Sbjct: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-F 107 Query: 2950 CIMIDCGHPGVPPNAVLSGEK-YTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQ 3005 CI C HPG N + + +FGS + +SC+ L+G ++ C++ WS Sbjct: 108 CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167 Query: 3006 PHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN---- 3059 P C C P +G S +E+ + +V Y+CD + L G +C Sbjct: 168 PQCE---IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224 Query: 3060 GSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFS--SSVIYSCMEGYILSGPSVRQCTA 3117 G W P C+ + C P + +G++ G ++ ++++ C +G++L G SV C A Sbjct: 225 GVWRPSPPTCEKITCRKPDVS-HGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283 Query: 3118 NGTWSGTLPNCTIISCGD-PGIP-ANGLRY-----GDDYVVGQNVSYMCQPGYTMELNGS 3170 + W+ + P C SC + P IP A+ Y D YVVG + Y C PGY + Sbjct: 284 DSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEP 343 Query: 3171 RIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN---------FDWGFSISYICSP 3221 C N W+ C A+ CP P+++NG + + +G IS+ C Sbjct: 344 TTVICQKNLRWTPYQ-GCEALCCP-EPKLNNGEITQHRKSRPANHCVYFYGDEISFSC-- 399 Query: 3222 GYELS-FPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG--KREGKSFIYQSEVSFSCN 3278 +E S F A+ C G+GTWS P C C P A G K+ ++ E+ + C+ Sbjct: 400 -HETSRFSAI--CQGDGTWSPRTPSC-GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECD 455 Query: 3279 FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFH 3338 +ILVG + C + WS +P C + C P + + + V Sbjct: 456 KGYILVGQAKLSC-SYSHWSAPAPQC----KALCRKPELVNGRLSVDKDQYVEPENVTIQ 510 Query: 3339 CKKGHLLQGSTTRTCLPDLTWSGIQPEC---IPHSCKQ 3373 C G+ + G + TC + TW P+C P C+Q Sbjct: 511 CDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQ 548 Score = 156 bits (394), Expect = 4e-37 Identities = 141/518 (27%), Positives = 214/518 (41%), Gaps = 45/518 (8%) Query: 2718 SCGELPT-----PPNGNKIGTQTSYGSTAIFTCDLGFMLVGSA-VRECLSSGLWSESETR 2771 +CG PT P + T+ G+T +TC G++ S C S G W + T Sbjct: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYN-TF 107 Query: 2772 CLAGHCGIPELIVNGQV-IGENYGYRDTVVYQCNPGFRLIGSSVRICQ-QDHN--WSGQL 2827 C+ C P + NGQV I + + + + C+ GF LIGS+ C+ QD WS L Sbjct: 108 CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167 Query: 2828 PSCVPVSCGHPGSPIYGRTSG--NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQ----W 2881 P C V C P GR SG N + + VT+SC+ + + G C + W Sbjct: 168 PQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW 227 Query: 2882 SHPPPMCKVVNCSDPGIPANSKRESKIEHGN-FTYGTVVFYDCNPGYFLFGSSVLICQPN 2940 PP C+ + C P + S E G + Y + + C G+ L GSSV+ C + Sbjct: 228 RPSPPTCEKITCRKPDV---SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDAD 284 Query: 2941 GQWDKPLPECIMIDCGH-PGVPPNA------VLSGEKYTFGSTVHYSC-TGKRSLLGQSS 2992 +W+ P C C + P +P + + Y G+ + Y C G + + + Sbjct: 285 SKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPT 344 Query: 2993 RT-CQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKS--TVRYACDTGYILH 3049 CQ N W+ Q G C +P Q R + Y + + H Sbjct: 345 TVICQKNLRWTPYQ----GCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCH 400 Query: 3050 GSEERT--CLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTF-SSSVIYSCMEGYI 3106 + + C +G+W+ R P C + C P A+G + +F +IY C +GYI Sbjct: 401 ETSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYI 459 Query: 3107 LSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVSYMCQPGYTM 3165 L G + C+ + WS P C + C P + L D YV +NV+ C GY + Sbjct: 460 LVGQAKLSCSYSH-WSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGV 517 Query: 3166 ELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGR 3203 G + TC+ N TW +P C T Q+ G+ Sbjct: 518 V--GPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGK 553 Score = 144 bits (362), Expect = 2e-33 Identities = 130/512 (25%), Positives = 209/512 (40%), Gaps = 53/512 (10%) Query: 2951 IMIDCGHP-----GVPPNAVLSGEKYTFGSTVHYSCT-GKRSLLGQSSRTCQLNGHWSGS 3004 ++ +CG P P + L+ ++ G+T+ Y+C G + TC +G W + Sbjct: 46 VLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYN 105 Query: 3005 QPHCSGDATGTCGDPGTPGHGSRQ-ESNFRTKSTVRYACDTGYILHGSEERTCLANG--- 3060 C C PG +G + +++ S + ++C G+ L GS C Sbjct: 106 T-FC---IYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGV 161 Query: 3061 SWTGRQPECKAVQCGNPGTTANGKVFRIDGT-TFSSSVIYSCMEGYILSGPSVRQCTAN- 3118 W+ P+C+ V+C P NG+ + + SV YSC + L G + CT Sbjct: 162 GWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVEN 221 Query: 3119 ---GTWSGTLPNCTIISCGDPGIPANGL--RYGDDYVVGQNVSYMCQPGYTMELNGSRIR 3173 G W + P C I+C P + + +G Y + + CQ G+ L GS + Sbjct: 222 ETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFV--LRGSSVI 279 Query: 3174 TCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG----TNFDW---GFSISYICSPGYELS 3226 C + W+ P C +C P I + E T D G + Y C PGY+ + Sbjct: 280 HCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPT 339 Query: 3227 F--PAVLTCVGNGTWS---GEVPQCLPKFCGDPGIPAQGKREGKS----FIYQSEVSFSC 3277 P + C N W+ G C P+ + G Q ++ + + Y E+SFSC Sbjct: 340 TDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC 399 Query: 3278 NFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFGFQVGSVV 3335 + + ICQ DGTWS +P C + C P HG Q++++ F ++ Sbjct: 400 HE----TSRFSAICQGDGTWSPRTPSCGD----ICNFPPKIAHGHYKQSSSYSFFKEEII 451 Query: 3336 QFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLI 3395 + C KG++L G +C WS P+C C++PE V D + Sbjct: 452 -YECDKGYILVGQAKLSCSYS-HWSAPAPQC-KALCRKPELVNGRLSVDKDQYVEPENVT 508 Query: 3396 YTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3427 C G+ + G + C + TW +VP CE Sbjct: 509 IQCDSGYGVVG-PQSITCSGNRTWYPEVPKCE 539 Score = 132 bits (331), Expect = 8e-30 Identities = 111/446 (24%), Positives = 178/446 (39%), Gaps = 44/446 (9%) Query: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588 C P +G + +T S + ++C GF L+G +++ C G W P+P C+ Sbjct: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGV-GWSHPLPQCE 171 Query: 2589 AISCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSD--GTWSNHN 2644 + C P NG + Y G VTY C+ + L + +++ G W Sbjct: 172 IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW--RP 229 Query: 2645 KTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGT 2704 P C +TC + + HG G Y YK +VF C G+ G + I C + Sbjct: 230 SPPTCEKITCRKPD---VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC--DAD 284 Query: 2705 WSWRNERPYCQIISCGELPTPPNGN-----KIGTQTSY--GSTAIFTCDLGFMLVGSAVR 2757 W P C+ SC LP P+ + + + Y G+ + C G+ Sbjct: 285 SKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPT 344 Query: 2758 E--CLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN---------YGYRDTVVYQCNPG 2806 C + W+ + C A C P+L NG++ Y Y D + + C+ Sbjct: 345 TVICQKNLRWTPYQ-GCEALCCPEPKL-NNGEITQHRKSRPANHCVYFYGDEISFSCHET 402 Query: 2807 FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG--RTSGNGFNFNDVVTFSCNIG 2864 R ICQ D WS + PSC + C P +G + S + F + + + C+ G Sbjct: 403 SRFSA----ICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKG 457 Query: 2865 YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCN 2924 Y++ G K C + WS P P CK + C P + N + ++ + V C+ Sbjct: 458 YILVGQAKLSCSYS-HWSAPAPQCKAL-CRKPEL-VNGR--LSVDKDQYVEPENVTIQCD 512 Query: 2925 PGYFLFGSSVLICQPNGQWDKPLPEC 2950 GY + G + C N W +P+C Sbjct: 513 SGYGVVGPQSITCSGNRTWYPEVPKC 538 Score = 100 bits (248), Expect = 3e-20 Identities = 94/362 (25%), Positives = 144/362 (39%), Gaps = 45/362 (12%) Query: 2552 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILT---TDY 2608 V ++CD F L+G +S C + W P C+ I+C P ++G +++ Y Sbjct: 199 VTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIY 257 Query: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRW- 2667 + + C G+ L + C +D W + P C +C IN + H W Sbjct: 258 NYKDTIVFKCQKGFVLRGSSVIH--CDADSKW--NPSPPACEPNSC--INLPDIPHASWE 311 Query: 2668 ---RIVNGSHYEYKTKVVFSCDPGYHGL--GPASIECLPNGTWSWRNERPY--CQIISCG 2720 R Y T + + C PGY P ++ C N W+ PY C+ + C Sbjct: 312 TYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-----PYQGCEALCCP 366 Query: 2721 ELPTPPNGNKIGTQTS---------YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETR 2771 E P NG + S YG F+C SA+ C G WS Sbjct: 367 E-PKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRF--SAI--CQGDGTWSPRTPS 421 Query: 2772 CLAGHCGIPELIVNGQV-IGENYG-YRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2829 C C P I +G +Y +++ ++Y+C+ G+ L+G + C H WS P Sbjct: 422 C-GDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQ 479 Query: 2830 CVPVSCGHPGSPIYGRTSGNGFNF--NDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPM 2887 C + C P + GR S + + + VT C+ GY + GP C NR W P Sbjct: 480 CKAL-CRKP-ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK 537 Query: 2888 CK 2889 C+ Sbjct: 538 CE 539 Score = 98.2 bits (243), Expect = 1e-19 Identities = 77/261 (29%), Positives = 113/261 (43%), Gaps = 23/261 (8%) Query: 3193 CPTPPQISNGR-----LEGTNFDWGFSISYICSPGYELSFPA-VLTCVGNGTWSGEVPQC 3246 C PP +S L T F G ++ Y C PGY S LTC +G W C Sbjct: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FC 108 Query: 3247 LPKFCGDPGIPAQGKREGKSFI-YQSEVSFSCNFPFILVGSSTRICQADGT---WSGSSP 3302 + K C PG G+ E K+ + + S++ FSC+ F L+GS+T C+ WS P Sbjct: 109 IYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLP 168 Query: 3303 HCIEPTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDL---- 3357 C C+ P R+G + F G V + C L G + +C + Sbjct: 169 QC---EIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIG 225 Query: 3358 TWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGY--TLIYTCQPGFFLAGGTEHRVCRS 3415 W P C +C++P+ +H +V P + Y T+++ CQ GF L G + C + Sbjct: 226 VWRPSPPTCEKITCRKPDV-SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIH-CDA 283 Query: 3416 DNTWTGKVPICEAGSKILVKD 3436 D+ W P CE S I + D Sbjct: 284 DSKWNPSPPACEPNSCINLPD 304 Score = 56.2 bits (134), Expect = 6e-07 Identities = 60/241 (24%), Positives = 95/241 (39%), Gaps = 35/241 (14%) Query: 2175 VYQAYQL-QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTC-LHGVSRN 2231 VY + + + C P RNG V I D + G I F C G+ LIG++ C + Sbjct: 103 VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162 Query: 2232 WNHPLPRCEAL-CGGNITAMNG------TIYSPGYPDEYPNFQDCFWLVRVPPGNGIYIN 2284 W+HPLP+CE + C NG Y+ G+ Y + F L+ + N Sbjct: 163 WSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTY-SCDPRFSLLGHASISCTVEN 221 Query: 2285 FTV---LQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSG 2341 T+ + P + IT P + + +Y+ + I+ K F G Sbjct: 222 ETIGVWRPSPPTCEKITC------RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRG 275 Query: 2342 FFVLSYHAYQLRVCQPPPPVPNAEI---------------LTEDDEFEIGDIIRYQCLPG 2386 V+ A PP PN+ I T++D + +G ++RY+C PG Sbjct: 276 SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335 Query: 2387 F 2387 + Sbjct: 336 Y 336 Score = 50.4 bits (119), Expect = 3e-05 Identities = 112/479 (23%), Positives = 168/479 (35%), Gaps = 108/479 (22%) Query: 1305 VYTSFEL-SHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERR-A 1362 VY +F + C PG + G GS I + C+ G+ L GS+ +C +R Sbjct: 103 VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162 Query: 1363 WDYPLPSC-IAEC-------GGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVS 1414 W +PLP C I +C GR GE + Y + + C DP Sbjct: 163 WSHPLPQCEIVKCKPPPDIRNGRHSGEEN------FYAYGFSVTYSC------DP-RFSL 209 Query: 1415 LQFLAFDTEASHDILRVW-DGPPENDMLL---KEISGSLIPEGIHSTLNIVTIQFDTDFY 1470 L + ++ + VW PP + + ++S + G N DT + Sbjct: 210 LGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYK----DTIVF 265 Query: 1471 ISKSGFAIQFSSSV-----------ATACRD------PGVPMNG------TRNGDGREPG 1507 + GF ++ SS + AC P +P D G Sbjct: 266 KCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVG 325 Query: 1508 DTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHP 1567 + ++C PGY+ +E T I +N W P C A C ++G I Sbjct: 326 TVLRYRCHPGYKPTTDEPTTVICQKN-LRWTPYQG-CEALCCPEPKLNNGEITQ------ 377 Query: 1568 YPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQD-SKLPER 1626 + SR + + D ISFS F I G + SP S D P + Sbjct: 378 HRKSRPANHCVYFYGDE------ISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPK 431 Query: 1627 IESSSNTMHLAFRSDGSVSY----------TGFHLEYKAKL--------------RESCF 1662 I H ++ S S+ G+ L +AKL + C Sbjct: 432 I------AHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCR 485 Query: 1663 DPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 P ++NG RL +D Y VT CD+GY + G ++TC G W +P C Sbjct: 486 KP-ELVNG-RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC----SGNRTWYPEVPKC 538 Score = 49.7 bits (117), Expect = 5e-05 Identities = 96/440 (21%), Positives = 155/440 (35%), Gaps = 71/440 (16%) Query: 1677 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNR--ALPSCHAPCGSRSTGSEGTVL 1734 +K G+T+ Y C GYV + +ST T DG +N C P R+ E Sbjct: 71 FKTGTTLKYTCLPGYV-RSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVE---- 125 Query: 1735 SPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSL--- 1791 + S G +S + + F + G + + D + P Q ++ Sbjct: 126 ---IKTDLSFGSQIEFSCS--EGFFLIGSTTS-RCEVQDRGVGWSHPLPQCEIVKCKPPP 179 Query: 1792 ---SGSHSGESLPLSSGNQITI----RFTSVG----PITAKGFHF-VYQAVPRTSSTQCS 1839 +G HSGE + G +T RF+ +G T + V++ P T Sbjct: 180 DIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITC 239 Query: 1840 SVPEPRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1896 P+ G + G + +++F C G++L GS I C+ + ++WN S P C Sbjct: 240 RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD----ADSKWNPSPPAC- 294 Query: 1897 VPCGGILTKRKGTILSPGYPEPYDNNLNCV-----------WKITVPEGAGIQVQVVSFA 1945 P I YP P ++ V +K T E + Q Sbjct: 295 EPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQ----- 349 Query: 1946 TEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYT 2005 W + P+L +G H + +N+ + +IS S Sbjct: 350 KNLRWTPYQGCEALCCPEPKLN--NGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSA 407 Query: 2006 AIGLDSCPEPQTPSSG-------------IKIGDRY-MVGDVVSFQCDQGYSLQGHSHIT 2051 D P+TPS G K Y + + ++CD+GY L G + ++ Sbjct: 408 ICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLS 467 Query: 2052 CMPGPVRRWNYPIPICLAQC 2071 C W+ P P C A C Sbjct: 468 C---SYSHWSAPAPQCKALC 484 Score = 47.0 bits (110), Expect = 3e-04 Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 2/64 (3%) Query: 446 CPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 C PGE NG+ I +D S GS ++FSC E + L G+ + C+ + + WS P C+ Sbjct: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCE-VQDRGVGWSHPLPQCE 171 Query: 505 VKTC 508 + C Sbjct: 172 IVKC 175 Score = 44.7 bits (104), Expect = 0.002 Identities = 46/232 (19%), Positives = 94/232 (40%), Gaps = 35/232 (15%) Query: 986 FSIGSTVSFSCDSGYRLSHEEP--LLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGY 1043 + +G+ + + C GY+ + +EP ++C+KN W+ P C+ALC + + +G I + Sbjct: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQ--H 378 Query: 1044 PEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGS--DL 1101 + P + +C + +G + F+ H + + I + P G + Sbjct: 379 RKSRPAN-HCVY----FYGDEISFSCH-----ETSRFSAICQGDGTWSPRTPSCGDICNF 428 Query: 1102 PPTINAG------LYGNFRAQLRFISD---FSISYEGFNITFSEYNLEPCEDPGIPQYGS 1152 PP I G Y F+ ++ + D + + ++S ++ + + + Sbjct: 429 PPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPE 488 Query: 1153 RIGFNFGIG-------DTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1197 + + + +T C SGY + G I C G R W +P+C Sbjct: 489 LVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC--SGNRTWYPEVPKC 538 Score = 43.1 bits (100), Expect = 0.005 Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%) Query: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503 C P + NG+ G + ++ G +V +SCD + L G SI+C E W P C Sbjct: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234 Query: 504 KVKTC 508 + TC Sbjct: 235 EKITC 239 Score = 42.7 bits (99), Expect = 0.007 Identities = 74/333 (22%), Positives = 114/333 (34%), Gaps = 92/333 (27%) Query: 1488 CRDPGVPMNGTRNGDGR--EPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1545 CR P V +G G DT+VF+C G+ L+G I C +++ W PSPP C Sbjct: 239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC-DADSK--WNPSPPACE 295 Query: 1546 APCGGNLTGSSGFILSPNFPH------PYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1599 NL P+ PH P P D YV+ + + P Y Sbjct: 296 PNSCINL---------PDIPHASWETYPRPTKEDV---------YVVGTV-LRYRCHPGY 336 Query: 1600 DFLYIYDGPDSNSPLIGSFQDSK------------LPE-RIESSSNTMHLAFR-SDGSVS 1645 P ++ P Q + PE ++ + T H R ++ V Sbjct: 337 K-------PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVY 389 Query: 1646 YTGFHLEYK-----------------AKLRESCFD----PGNIMNGTRLGMDYKLGST-- 1682 + G + + + SC D P I +G YK S+ Sbjct: 390 FYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHG-----HYKQSSSYS 444 Query: 1683 -----VTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS-RSTGSEGTVLSP 1736 + Y CD GY+L G + L+C W+ P C A C +V Sbjct: 445 FFKEEIIYECDKGYILVGQAKLSCSYSH-----WSAPAPQCKALCRKPELVNGRLSVDKD 499 Query: 1737 NY--PKNYSVGHNCVYSIAVPKEFVVFGQFVFF 1767 Y P+N ++ + Y + P+ G ++ Sbjct: 500 QYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532 Score = 42.0 bits (97), Expect = 0.011 Identities = 57/237 (24%), Positives = 77/237 (32%), Gaps = 64/237 (27%) Query: 970 CLDPGIPVHGR-RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE---KNHWWSHPLPTCDA 1025 C PG +G+ D S GS + FSC G+ L CE + WSHPLP C+ Sbjct: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI 172 Query: 1026 L-C--GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLL 1082 + C D+R + G FY + T++ D F L H Sbjct: 173 VKCKPPPDIRNGRHS----GEENFYAYGFSVTYSCD-----------PRFSLLGHASISC 217 Query: 1083 ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1142 EN + PPT IT C Sbjct: 218 TVENETIG------VWRPSPPTCE------------------------KIT--------C 239 Query: 1143 EDPGIPQYGSRIGFN--FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1197 P + GF + DT+ F C G+ L G+S I C + W+ P C Sbjct: 240 RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK--WNPSPPAC 294 Score = 41.2 bits (95), Expect = 0.019 Identities = 22/77 (28%), Positives = 39/77 (50%), Gaps = 2/77 (2%) Query: 1661 CFDPGNIMNGTRLGMD--YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 C P +I NG G + Y G +VTY CD + L G+++++C + ++ W + P+C Sbjct: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234 Query: 1719 HAPCGSRSTGSEGTVLS 1735 + S G ++S Sbjct: 235 EKITCRKPDVSHGEMVS 251 Score = 40.4 bits (93), Expect = 0.033 Identities = 16/40 (40%), Positives = 26/40 (65%), Gaps = 3/40 (7%) Query: 2204 QTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALC 2243 + I +EC GY L+G + L+C + +W+ P P+C+ALC Sbjct: 448 EEIIYECDKGYILVGQAKLSCSYS---HWSAPAPQCKALC 484 Score = 40.0 bits (92), Expect = 0.043 Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%) Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERL--QMDGAPPVC 2412 C+PPP + N E++ + G + Y C P F+L+G+A ++C + +PP C Sbjct: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234 Query: 2413 Q 2413 + Sbjct: 235 E 235 Score = 38.5 bits (88), Expect = 0.12 Identities = 62/263 (23%), Positives = 87/263 (33%), Gaps = 65/263 (24%) Query: 2197 GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYS 2256 G + TI F+C G+ L G+S + C WN P CE N I Sbjct: 254 GPIYNYKDTIVFKCQKGFVLRGSSVIHC--DADSKWNPSPPACEP---------NSCINL 302 Query: 2257 PGYP----DEYPNFQDCFWLVRVPPGNGIYINFTVLQT------EPIYDFITV------- 2299 P P + YP P +Y+ TVL+ +P D T Sbjct: 303 PDIPHASWETYPR----------PTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNL 352 Query: 2300 ----WDG--------PDQNSPQIGQF-SGNTALESVYSTSNQILIKFHSDFTTSGFFVLS 2346 + G P N+ +I Q A VY ++I H TS F + Sbjct: 353 RWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE---TSRFSAIC 409 Query: 2347 YH--AYQLR------VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCR 2398 + R +C PP + + + I Y+C G+ LVG A L+C Sbjct: 410 QGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCS 469 Query: 2399 LGERLQMDGAPPVCQVLCPANEL 2421 P C+ LC EL Sbjct: 470 YS---HWSAPAPQCKALCRKPEL 489 Score = 37.0 bits (84), Expect = 0.36 Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%) Query: 1142 CEDPGIPQYGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRC-V 1198 C PG + G I + G + FSCS G+ L G++ C R V WS PLP+C + Sbjct: 113 CRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI 172 Query: 1199 AEC 1201 +C Sbjct: 173 VKC 175 Score = 36.6 bits (83), Expect = 0.47 Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 3/68 (4%) Query: 786 YNTFG-HNECPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVM 843 YNTF + C PG N + + GS I C EGF G+ T C + D V Sbjct: 104 YNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLI-GSTTSRCEVQDRGVG 162 Query: 844 WSGLIPKC 851 WS +P+C Sbjct: 163 WSHPLPQC 170 Score = 36.6 bits (83), Expect = 0.47 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 2/60 (3%) Query: 620 EKESCGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677 EK +C P + G G ++ +D + F+CQ GF L G I C +++W+ + P C Sbjct: 235 EKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294 Score = 36.2 bits (82), Expect = 0.61 Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 3/57 (5%) Query: 2012 CPEPQTPSSGIKIG-DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067 C +P+ + + + D+Y+ + V+ QCD GY + G ITC R W +P C Sbjct: 484 CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGN--RTWYPEVPKC 538 Score = 35.4 bits (80), Expect = 1.0 Identities = 51/239 (21%), Positives = 83/239 (34%), Gaps = 56/239 (23%) Query: 447 PDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVK 506 PD E G ++ T+ F C + +VL+G+ I C + + W+ P C+ Sbjct: 242 PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC----DADSKWNPSPPACEPN 297 Query: 507 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 566 +C + P ++ + P + D V+V+ V + GY T Sbjct: 298 SCINLPDIPHASWETYPRPTKED-----VYVVGTV----------LRYRCHPGYKPTT-- 340 Query: 567 DGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGD 626 +P TV + + W Q E++ K+N EI + Sbjct: 341 -----DEPTTV-------------ICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSR 382 Query: 627 PGTP-LYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP----ICIFP 680 P +Y + FS + RF S +CQ + WS P IC FP Sbjct: 383 PANHCVYFYGDEISFSCHETSRF------------SAICQGDGTWSPRTPSCGDICNFP 429 Score = 32.7 bits (73), Expect = 6.8 Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 13/93 (13%) Query: 111 FSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVG------DKIRYSC 164 FS TS F+ G + ++ SCG+ P + +G ++I Y C Sbjct: 397 FSCHETSRFSAICQGDGTWSP--RTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454 Query: 165 VTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197 GYIL G +L+C + + W P P C+A Sbjct: 455 DKGYILVGQAKLSC-----SYSHWSAPAPQCKA 482 Score = 32.3 bits (72), Expect = 8.9 Identities = 11/40 (27%), Positives = 20/40 (50%) Query: 638 DGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677 D + + + +C G+ ++G +SI C N W +P C Sbjct: 499 DQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538 >gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo sapiens] Length = 730 Score = 146 bits (369), Expect = 3e-34 Identities = 107/304 (35%), Positives = 146/304 (48%), Gaps = 29/304 (9%) Query: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124 A CGG + G I SP +P +Y S C W I + GF V L F +F E +DY Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 2125 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2184 LEVR G SE+ST+IGR G + P + ST+ L F SD S NK GF + + ++ C Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551 Query: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244 RP R G T+G + C PGY L + RCEA CG Sbjct: 552 S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592 Query: 2245 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2300 G +T +NG+I SPG+P EYP ++C W + P I + F +TE YDF+ V Sbjct: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652 Query: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRVCQPPP 2359 G +S G+F G+ E + S N + ++F SD T S F + + + QPP Sbjct: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPR 712 Query: 2360 PVPN 2363 P+ Sbjct: 713 GRPH 716 Score = 144 bits (364), Expect = 1e-33 Identities = 102/301 (33%), Positives = 142/301 (47%), Gaps = 30/301 (9%) Query: 1372 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1427 A CGG K + G I SP YP Y + C+W I+V G V L F +F+ E ++D Sbjct: 433 AICGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 1428 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1487 L V DG E+ L+ G P+ I ST + + ++F +D I+K+GFA+ F V Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551 Query: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1547 R P G + CDPGYEL ++R C A Sbjct: 552 SR----PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRR-----------------CEAA 590 Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603 CGG LT +G I SP +P YP +++C W + Y ISL F F E N YDF+ Sbjct: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1663 + G ++S L G F S+ PE I S N M + F+SD +VS GF + ++ R + Sbjct: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQP 710 Query: 1664 P 1664 P Sbjct: 711 P 711 Score = 136 bits (343), Expect = 3e-31 Identities = 92/300 (30%), Positives = 146/300 (48%), Gaps = 32/300 (10%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954 CGG + K G I SP YP+ Y + C+W+I V EG + + SF E + +D L+ Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494 Query: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 2014 DG ++ +G Y G P + STS+ L+L F SD S++ AGF + + +D C Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553 Query: 2015 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2072 P ++ + + S++C D GY L P +R C A CG Sbjct: 554 PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592 Query: 2073 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2128 G ++ +G I SPG+P YP + +C W + P + + LQF F TE +D++EVR Sbjct: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652 Query: 2129 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPR 2188 SG + S + G+ G + P + S + + F SD + +K+GF + + + + PR Sbjct: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPR 712 Score = 136 bits (343), Expect = 3e-31 Identities = 93/291 (31%), Positives = 140/291 (48%), Gaps = 32/291 (10%) Query: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLA 736 C + G + SP+YP+ Y + CIW I G + L+F F++E +D+L Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494 Query: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH-NECP 795 V+DG S S ++G + G E P + S S L L+F +D S++ GF + N F +EC Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV--NFFKEVDECS 552 Query: 796 DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 855 P R G CE+ + T G+ +C D + +C A C Sbjct: 553 RPN------RGG------------CEQRCLNTLGSYKCSC---DPGYELAPDKRRCEAAC 591 Query: 856 GGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEV 911 GG + +G I SPGWP Y + NC W + A + I + F+ F+TE N YD +EV Sbjct: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651 Query: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYES 962 G S L G + G++ P+ + S N + + F +DN+ S GFK H+ S Sbjct: 652 RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702 Score = 136 bits (342), Expect = 4e-31 Identities = 98/300 (32%), Positives = 143/300 (47%), Gaps = 40/300 (13%) Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1601 A CGG++ G I SPN+P Y S+ C W I V+ + + L F SF IE + YD+ Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 1602 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1661 L + DG +S LIG + + P+ I+S+S+ + L F SDGS++ GF + + ++ E C Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551 Query: 1662 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 P R G + + +T+ Y CD GY L P R C Sbjct: 552 SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587 Query: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1774 A CG T G++ SP +PK Y NC++ + P ++ + QF FF+T +DV Sbjct: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647 Query: 1775 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1831 VEV G T S L GS E + S N + + F S ++ KGF HF + P Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRP 706 Score = 124 bits (311), Expect = 2e-27 Identities = 84/283 (29%), Positives = 138/283 (48%), Gaps = 29/283 (10%) Query: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 563 CG +++ G SPN+P Y + C+W I V+ + + F+ F++E YD L Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493 Query: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623 + DG + T++ G PD I S SS++WL +D S+ GF VN+ + E + Sbjct: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550 Query: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683 C P G E + + C G+EL +K C C Sbjct: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593 Query: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 739 T G++ SP +P+ Y N NCIW +++ RI L F+ F+ E ++DF+ V+ Sbjct: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653 Query: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 782 G + +S + G F G+E P +TS + +R+EF++D+++S +GF Sbjct: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696 Score = 115 bits (287), Expect = 1e-24 Identities = 88/291 (30%), Positives = 126/291 (43%), Gaps = 38/291 (13%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CGG +K G I+SP +P Y C W I E + + FQSF +E YDYL Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139 + DGH + R G+ P + ST S L+ SD +++ GF V +++E+ S Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 N G + L + + SC GY L + R E Sbjct: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589 Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 255 ACGG + +G I+SP +P EY N +C W +VA ISL F F+ E KYD++ Sbjct: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649 Query: 256 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 E+ L G P I S N +R+ F +D+ +GF A + Sbjct: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700 Score = 113 bits (283), Expect = 3e-24 Identities = 84/291 (28%), Positives = 132/291 (45%), Gaps = 32/291 (10%) Query: 853 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 908 A CGG G I SP +P Y+ S C W I+ G + +TF+ F+ E + YD Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 968 LEV DG + S L+G Y G + P + S+S+ ++L F +D S + GF +++ Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EVD 549 Query: 969 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 1028 C P G + + SCD GY L+ ++ C+A CG Sbjct: 550 ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592 Query: 1029 GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLIT 1084 G + +G+I SPG+P+ YP + NC W + + F F E + +D++ + Sbjct: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652 Query: 1085 ENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1134 + L + GS+ P I + Y N R + F SD ++S +GF F Sbjct: 653 SGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHF 700 Score = 113 bits (282), Expect = 4e-24 Identities = 84/294 (28%), Positives = 128/294 (43%), Gaps = 35/294 (11%) Query: 1720 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1774 A CG G + SPNYP +Y C++ I V + F V F F+ HD Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 1775 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1834 +EV DG ++ S+L+ G + + S+ +++ ++F S G I GF + Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551 Query: 1835 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894 S E R +G S C+PGY E P+ Sbjct: 552 SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586 Query: 1895 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1950 C CGG LTK G+I SPG+P+ Y N NC+W++ P I +Q F TE N + Sbjct: 587 CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646 Query: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 2004 D ++ G ++ G + G+ P ++ S NN+ + F+SD +VS GF + Sbjct: 647 DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700 Score = 105 bits (262), Expect = 8e-22 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 34/295 (11%) Query: 1024 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1079 +A+CGGDV+ G I SP YP+ Y S C W + V+ G V F +F +E H +D Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 1080 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138 YL + + S + L R G + P I + + R L+F+SD SI+ GF + F + Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547 Query: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 ++ C P R G + SC GY L RC Sbjct: 548 VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588 Query: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1255 A CG T G + SP +P Y N CI+ + I++ F DV K Sbjct: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648 Query: 1256 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308 + G + L G F G S + ++S N + +EF SD + +GF+ + S Sbjct: 649 VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702 Score = 100 bits (250), Expect = 2e-20 Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%) Query: 2240 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2295 EA+CGG++ G I SP YPD+Y + C W ++V G + + F + E YD Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2353 ++ V DG ++S IG++ G + + STS+++ +KF SD +GF V + ++ Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549 Query: 2354 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413 C P +CL +G+ +C G L D C+ Sbjct: 550 ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588 Query: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2469 C +L+ G I SPG+P YP + C W + Y I++ +FF+TE ++ Sbjct: 589 AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646 Query: 2470 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526 D ++V G S + G ITS + + +++ +D+ +KKGF+ + + Sbjct: 647 DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702 Score = 90.9 bits (224), Expect = 2e-17 Identities = 114/438 (26%), Positives = 176/438 (40%), Gaps = 79/438 (18%) Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255 ACG T++ S+G SSP +PN Y + C W I PG+ I L FT + YDY+ Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380 Query: 256 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311 E+ P G +P PI+S + L + F + SN +GF A Y+ Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE-------A 433 Query: 312 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTS 371 G++++ G I + P D S V I ++SE V +T ++ ++ + S Sbjct: 434 ICGGDVKK----DYGHIQSPNYPDDYRPSKVCIWRI-QVSEGFHVGLT-FQSFEIERHDS 487 Query: 372 --KDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSN 429 D L ++S+ R+ +K D KS +L+ Sbjct: 488 CAYDYLEVRDGHSESSTLIGRYC--------------GYEKPDDIKSTSSRLW------- 526 Query: 430 KFSILNEGGIKTAS---NLCPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAK 482 +++G I A N + E R G + +LGS + SCD Y L K Sbjct: 527 -LKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGS-YKCSCDPGYELAPDK 584 Query: 483 SITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVN 542 C+ CG L +G+ TSP +P +Y N C+W + A Sbjct: 585 R-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA-P 624 Query: 543 TNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDLIVSMSSQMW 598 T I + F+ F+ E G D D EV T L G F P++I S + M Sbjct: 625 TQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMR 682 Query: 599 LHLQTDESVGSVGFKVNY 616 + ++D +V GFK ++ Sbjct: 683 VEFKSDNTVSKKGFKAHF 700 Score = 73.9 bits (180), Expect = 3e-12 Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 13/120 (10%) Query: 690 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPES 745 G SP+YP GY +++C+W I PG +I L+F DL +D++ V+DG ++ Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390 Query: 746 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT---------FGHNECPD 796 P+ G F G+++P + S L +EF++ + G+GF Y +GH + P+ Sbjct: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPN 450 Score = 70.5 bits (171), Expect = 3e-11 Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 8/141 (5%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 80 CGG L LNG+I SPG+P YP NC W ++A + RI + F F E +YD++ Sbjct: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140 + G + + G P +TS + + SD VS GFK ++ + + Sbjct: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPAL-- 708 Query: 141 PGVPPKGVLYGTRFDVGDKIR 161 PP+G + +F V + R Sbjct: 709 --QPPRGRPHQLKFRVQKRNR 727 Score = 64.3 bits (155), Expect = 2e-09 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%) Query: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2293 L +C A CG + G SP YP+ Y C W + V PG I +NFT L Sbjct: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374 Query: 2294 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2345 YD++ V DG + +P G+F G+ E + ST +++ ++F S++ GFF + Sbjct: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430 Score = 62.8 bits (151), Expect = 6e-09 Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%) Query: 451 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 498 EP+ + +G + S + ++ + Y + G K QR + Sbjct: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312 Query: 499 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 557 R + K CG LQ +G F+SP +P Y ++ CVW I+ K+I +NF DL Sbjct: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371 Query: 558 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 614 YD + + DG P + GS +P+ IVS S++W+ ++ + GF Sbjct: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429 Query: 615 NYKEIEKESCGDPGTPLYG 633 Y+ I CG YG Sbjct: 430 VYEAI----CGGDVKKDYG 444 Score = 62.4 bits (150), Expect = 8e-09 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%) Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603 CG L S+G SP +P+ Y C W I+V I L F S + + YD++ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1655 + DG +PL G F SKLPE I S+ + + + FRS + GF Y+A Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Score = 61.2 bits (147), Expect = 2e-08 Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954 CG L G SP YP Y +++CVW+I+V G I + S + +D ++ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2007 DG AP G + G+ +P + ST + L++ F+S + GF Y AI Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434 Score = 60.8 bits (146), Expect = 2e-08 Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%) Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2126 CG + D +G SP +P Y + + C W I++ G + L F + S +DY+E Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 VR G + + GR G ++P + ST + F S + +GF VY+A Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Score = 59.7 bits (143), Expect = 5e-08 Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%) Query: 2427 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2482 G I SP YPD Y ++C W I V +G+++ + + F+ E+ +D L+V DG + +S Sbjct: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502 Query: 2483 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2540 LI Y +I S ++L++ +D NK GF + + CS P G Sbjct: 503 STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559 Query: 2541 ISQTGGQLNSVVRWACDRGFRL 2562 + L S + +CD G+ L Sbjct: 560 EQRCLNTLGS-YKCSCDPGYEL 580 Score = 59.3 bits (142), Expect = 7e-08 Identities = 42/145 (28%), Positives = 63/145 (43%), Gaps = 8/145 (5%) Query: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253 E CGG ++ G I SP++P++Y + C W I G + L F F++E YD Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 254 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309 YLE+ SE T+ G P I S + L L FV+D + GF+ + Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551 Query: 310 HTTSTGELEEHNRTTTGAIAVASTP 334 + G E+ T G+ + P Sbjct: 552 SRPNRGGCEQRCLNTLGSYKCSCDP 576 Score = 58.5 bits (140), Expect = 1e-07 Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%) Query: 837 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 896 L G + + + KC A CG +G SP +P Y ++C W I PG I + Sbjct: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363 Query: 897 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 952 F + +++ L YD +EV DG +PL G + G+++P+ + S+ + +++ F + ++ Sbjct: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423 Query: 953 NNGFKIHYESV 963 GF YE++ Sbjct: 424 GKGFFAVYEAI 434 Score = 57.4 bits (137), Expect = 3e-07 Identities = 36/113 (31%), Positives = 46/113 (40%), Gaps = 4/113 (3%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CG TL+ G SP +P GY +C W I +I + F S L YDY+ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 133 + DG R R G LP P+ ST S + S GF YE + Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434 Score = 57.0 bits (136), Expect = 3e-07 Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%) Query: 1194 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1251 L +C A CG + ++ G SP YP Y + C++ I V G+ I ++ + L + Sbjct: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374 Query: 1252 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308 D +++ DG + L G F G+ + + ST ++LW+EF S + +GF VY + Sbjct: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Query: 1309 F-------ELSHCEDPGIP 1320 + H + P P Sbjct: 434 ICGGDVKKDYGHIQSPNYP 452 Score = 55.1 bits (131), Expect = 1e-06 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%) Query: 1713 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1769 R L C A CG S G SP YP YS +CV+ I+V P E ++ F +++ Sbjct: 314 RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372 Query: 1770 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827 L +D VEV DG +++ L GS E + +S+ +++ + F S KGF VY Sbjct: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431 Query: 1828 QAV 1830 +A+ Sbjct: 432 EAI 434 Score = 54.7 bits (130), Expect = 2e-06 Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%) Query: 1365 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1424 Y P+C G +S+G SP YP Y ++ C+W I V PG + L F + D Sbjct: 317 YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371 Query: 1425 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1478 S +D + V DG L GS +PE I ST + + ++F + ++ K FA+ Sbjct: 372 SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430 Score = 45.1 bits (105), Expect = 0.001 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%) Query: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1082 CG ++ +G SP YP Y ++C W + VT G+ + NF + L +DY+ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1083 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1120 + + PL R GS LP I ++ L+ FR+ ++ Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423 Score = 38.9 bits (89), Expect = 0.095 Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%) Query: 2416 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2470 CPA E DSTG SP YP+ Y C W ISV G I + + +D Sbjct: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378 Query: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530 ++V DG ++P+ G I S +++++ + KGF Y A C Sbjct: 379 YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436 Query: 2531 TPESPPHGYIIS 2542 +G+I S Sbjct: 437 GDVKKDYGHIQS 448 >gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo sapiens] Length = 823 Score = 145 bits (367), Expect = 6e-34 Identities = 102/280 (36%), Positives = 137/280 (48%), Gaps = 28/280 (10%) Query: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124 A CGG + G I SP +P +Y S C W I + GF V L F +F E +DY Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 2125 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2184 LEVR G SE+ST+IGR G + P + ST+ L F SD S NK GF + + ++ C Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551 Query: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244 RP R G T+G + C PGY L + RCEA CG Sbjct: 552 S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592 Query: 2245 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2300 G +T +NG+I SPG+P EYP ++C W + P I + F +TE YDF+ V Sbjct: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652 Query: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS 2340 G +S G+F G+ E + S N + ++F SD T S Sbjct: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVS 692 Score = 144 bits (362), Expect = 2e-33 Identities = 105/310 (33%), Positives = 146/310 (47%), Gaps = 31/310 (10%) Query: 1372 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1427 A CGG K + G I SP YP Y + C+W I+V G V L F +F+ E ++D Sbjct: 433 AICGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 1428 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1487 L V DG E+ L+ G P+ I ST + + ++F +D I+K+GFA+ F V Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551 Query: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1547 R P G + CDPGYEL ++R C A Sbjct: 552 SR----PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRR-----------------CEAA 590 Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603 CGG LT +G I SP +P YP +++C W + Y ISL F F E N YDF+ Sbjct: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1663 + G ++S L G F S+ PE I S N M + F+SD +VS GF + + L E D Sbjct: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVL-EGAGD 709 Query: 1664 PGNIMNGTRL 1673 + ++G L Sbjct: 710 RHSHLSGLEL 719 Score = 138 bits (347), Expect = 1e-31 Identities = 94/292 (32%), Positives = 141/292 (48%), Gaps = 32/292 (10%) Query: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLA 736 C + G + SP+YP+ Y + CIW I G + L+F F++E +D+L Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494 Query: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH-NECP 795 V+DG S S ++G + G E P + S S L L+F +D S++ GF + N F +EC Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV--NFFKEVDECS 552 Query: 796 DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 855 P R G CE+ + T G+ +C D + +C A C Sbjct: 553 RPN------RGG------------CEQRCLNTLGSYKCSC---DPGYELAPDKRRCEAAC 591 Query: 856 GGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEV 911 GG + +G I SPGWP Y + NC W + A + I + F+ F+TE N YD +EV Sbjct: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651 Query: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV 963 G S L G + G++ P+ + S N + + F +DN+ S GFK H+ SV Sbjct: 652 RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703 Score = 135 bits (341), Expect = 6e-31 Identities = 90/284 (31%), Positives = 140/284 (49%), Gaps = 32/284 (11%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954 CGG + K G I SP YP+ Y + C+W+I V EG + + SF E + +D L+ Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494 Query: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 2014 DG ++ +G Y G P + STS+ L+L F SD S++ AGF + + +D C Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553 Query: 2015 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2072 P ++ + + S++C D GY L P +R C A CG Sbjct: 554 PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592 Query: 2073 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2128 G ++ +G I SPG+P YP + +C W + P + + LQF F TE +D++EVR Sbjct: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652 Query: 2129 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGF 2172 SG + S + G+ G + P + S + + F SD + +K+GF Sbjct: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696 Score = 135 bits (340), Expect = 7e-31 Identities = 97/294 (32%), Positives = 141/294 (47%), Gaps = 40/294 (13%) Query: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1601 A CGG++ G I SPN+P Y S+ C W I V+ + + L F SF IE + YD+ Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 1602 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1661 L + DG +S LIG + + P+ I+S+S+ + L F SDGS++ GF + + ++ E C Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551 Query: 1662 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 P R G + + +T+ Y CD GY L P R C Sbjct: 552 SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587 Query: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1774 A CG T G++ SP +PK Y NC++ + P ++ + QF FF+T +DV Sbjct: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647 Query: 1775 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HF 1825 VEV G T S L GS E + S N + + F S ++ KGF HF Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHF 700 Score = 124 bits (311), Expect = 2e-27 Identities = 84/283 (29%), Positives = 138/283 (48%), Gaps = 29/283 (10%) Query: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 563 CG +++ G SPN+P Y + C+W I V+ + + F+ F++E YD L Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493 Query: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623 + DG + T++ G PD I S SS++WL +D S+ GF VN+ + E + Sbjct: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550 Query: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683 C P G E + + C G+EL +K C C Sbjct: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593 Query: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 739 T G++ SP +P+ Y N NCIW +++ RI L F+ F+ E ++DF+ V+ Sbjct: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653 Query: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 782 G + +S + G F G+E P +TS + +R+EF++D+++S +GF Sbjct: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696 Score = 115 bits (288), Expect = 8e-25 Identities = 87/314 (27%), Positives = 139/314 (44%), Gaps = 36/314 (11%) Query: 1720 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1774 A CG G + SPNYP +Y C++ I V + F V F F+ HD Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 1775 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1834 +EV DG ++ S+L+ G + + S+ +++ ++F S G I GF + Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551 Query: 1835 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894 S E R +G S C+PGY E P+ Sbjct: 552 SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586 Query: 1895 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1950 C CGG LTK G+I SPG+P+ Y N NC+W++ P I +Q F TE N + Sbjct: 587 CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646 Query: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010 D ++ G ++ G + G+ P ++ S NN+ + F+SD +VS GF + ++ L+ Sbjct: 647 DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV-LE 705 Query: 2011 SCPEPQTPSSGIKI 2024 + + SG+++ Sbjct: 706 GAGDRHSHLSGLEL 719 Score = 115 bits (287), Expect = 1e-24 Identities = 88/291 (30%), Positives = 126/291 (43%), Gaps = 38/291 (13%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CGG +K G I+SP +P Y C W I E + + FQSF +E YDYL Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139 + DGH + R G+ P + ST S L+ SD +++ GF V +++E+ S Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199 N G + L + + SC GY L + R E Sbjct: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589 Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 255 ACGG + +G I+SP +P EY N +C W +VA ISL F F+ E KYD++ Sbjct: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649 Query: 256 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302 E+ L G P I S N +R+ F +D+ +GF A + Sbjct: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700 Score = 113 bits (283), Expect = 3e-24 Identities = 84/291 (28%), Positives = 132/291 (45%), Gaps = 32/291 (10%) Query: 853 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 908 A CGG G I SP +P Y+ S C W I+ G + +TF+ F+ E + YD Sbjct: 433 AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492 Query: 909 LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 968 LEV DG + S L+G Y G + P + S+S+ ++L F +D S + GF +++ Sbjct: 493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EVD 549 Query: 969 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 1028 C P G + + SCD GY L+ ++ C+A CG Sbjct: 550 ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592 Query: 1029 GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLIT 1084 G + +G+I SPG+P+ YP + NC W + + F F E + +D++ + Sbjct: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652 Query: 1085 ENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1134 + L + GS+ P I + Y N R + F SD ++S +GF F Sbjct: 653 SGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHF 700 Score = 105 bits (262), Expect = 8e-22 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 34/295 (11%) Query: 1024 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1079 +A+CGGDV+ G I SP YP+ Y S C W + V+ G V F +F +E H +D Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 1080 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138 YL + + S + L R G + P I + + R L+F+SD SI+ GF + F + Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547 Query: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 ++ C P R G + SC GY L RC Sbjct: 548 VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588 Query: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1255 A CG T G + SP +P Y N CI+ + I++ F DV K Sbjct: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648 Query: 1256 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308 + G + L G F G S + ++S N + +EF SD + +GF+ + S Sbjct: 649 VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702 Score = 100 bits (250), Expect = 2e-20 Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%) Query: 2240 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2295 EA+CGG++ G I SP YPD+Y + C W ++V G + + F + E YD Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2353 ++ V DG ++S IG++ G + + STS+++ +KF SD +GF V + ++ Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549 Query: 2354 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413 C P +CL +G+ +C G L D C+ Sbjct: 550 ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588 Query: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2469 C +L+ G I SPG+P YP + C W + Y I++ +FF+TE ++ Sbjct: 589 AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646 Query: 2470 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526 D ++V G S + G ITS + + +++ +D+ +KKGF+ + + Sbjct: 647 DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702 Score = 94.0 bits (232), Expect = 2e-18 Identities = 119/456 (26%), Positives = 184/456 (40%), Gaps = 80/456 (17%) Query: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255 ACG T++ S+G SSP +PN Y + C W I PG+ I L FT + YDY+ Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380 Query: 256 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311 E+ P G +P PI+S + L + F + SN +GF A Y+ Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE-------A 433 Query: 312 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTS 371 G++++ G I + P D S V I ++SE V +T ++ ++ + S Sbjct: 434 ICGGDVKK----DYGHIQSPNYPDDYRPSKVCIWRI-QVSEGFHVGLT-FQSFEIERHDS 487 Query: 372 --KDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSN 429 D L ++S+ R+ +K D KS +L+ Sbjct: 488 CAYDYLEVRDGHSESSTLIGRYC--------------GYEKPDDIKSTSSRLW------- 526 Query: 430 KFSILNEGGIKTAS---NLCPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAK 482 +++G I A N + E R G + +LGS + SCD Y L K Sbjct: 527 -LKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGS-YKCSCDPGYELAPDK 584 Query: 483 SITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVN 542 C+ CG L +G+ TSP +P +Y N C+W + A Sbjct: 585 R-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA-P 624 Query: 543 TNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDLIVSMSSQMW 598 T I + F+ F+ E G D D EV T L G F P++I S + M Sbjct: 625 TQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMR 682 Query: 599 LHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGI 634 + ++D +V GFK ++ + E GD + L G+ Sbjct: 683 VEFKSDNTVSKKGFKAHFFSV-LEGAGDRHSHLSGL 717 Score = 73.9 bits (180), Expect = 3e-12 Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 13/120 (10%) Query: 690 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPES 745 G SP+YP GY +++C+W I PG +I L+F DL +D++ V+DG ++ Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390 Query: 746 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT---------FGHNECPD 796 P+ G F G+++P + S L +EF++ + G+GF Y +GH + P+ Sbjct: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPN 450 Score = 64.3 bits (155), Expect = 2e-09 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%) Query: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2293 L +C A CG + G SP YP+ Y C W + V PG I +NFT L Sbjct: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374 Query: 2294 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2345 YD++ V DG + +P G+F G+ E + ST +++ ++F S++ GFF + Sbjct: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430 Score = 62.8 bits (151), Expect = 6e-09 Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%) Query: 451 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 498 EP+ + +G + S + ++ + Y + G K QR + Sbjct: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312 Query: 499 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 557 R + K CG LQ +G F+SP +P Y ++ CVW I+ K+I +NF DL Sbjct: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371 Query: 558 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 614 YD + + DG P + GS +P+ IVS S++W+ ++ + GF Sbjct: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429 Query: 615 NYKEIEKESCGDPGTPLYG 633 Y+ I CG YG Sbjct: 430 VYEAI----CGGDVKKDYG 444 Score = 62.4 bits (150), Expect = 8e-09 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%) Query: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603 CG L S+G SP +P+ Y C W I+V I L F S + + YD++ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1655 + DG +PL G F SKLPE I S+ + + + FRS + GF Y+A Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Score = 61.2 bits (147), Expect = 2e-08 Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954 CG L G SP YP Y +++CVW+I+V G I + S + +D ++ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2007 DG AP G + G+ +P + ST + L++ F+S + GF Y AI Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434 Score = 60.8 bits (146), Expect = 2e-08 Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%) Query: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2126 CG + D +G SP +P Y + + C W I++ G + L F + S +DY+E Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178 VR G + + GR G ++P + ST + F S + +GF VY+A Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Score = 59.7 bits (143), Expect = 5e-08 Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%) Query: 2427 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2482 G I SP YPD Y ++C W I V +G+++ + + F+ E+ +D L+V DG + +S Sbjct: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502 Query: 2483 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2540 LI Y +I S ++L++ +D NK GF + + CS P G Sbjct: 503 STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559 Query: 2541 ISQTGGQLNSVVRWACDRGFRL 2562 + L S + +CD G+ L Sbjct: 560 EQRCLNTLGS-YKCSCDPGYEL 580 Score = 59.3 bits (142), Expect = 7e-08 Identities = 42/145 (28%), Positives = 63/145 (43%), Gaps = 8/145 (5%) Query: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253 E CGG ++ G I SP++P++Y + C W I G + L F F++E YD Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491 Query: 254 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309 YLE+ SE T+ G P I S + L L FV+D + GF+ + Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551 Query: 310 HTTSTGELEEHNRTTTGAIAVASTP 334 + G E+ T G+ + P Sbjct: 552 SRPNRGGCEQRCLNTLGSYKCSCDP 576 Score = 58.5 bits (140), Expect = 1e-07 Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%) Query: 837 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 896 L G + + + KC A CG +G SP +P Y ++C W I PG I + Sbjct: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363 Query: 897 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 952 F + +++ L YD +EV DG +PL G + G+++P+ + S+ + +++ F + ++ Sbjct: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423 Query: 953 NNGFKIHYESV 963 GF YE++ Sbjct: 424 GKGFFAVYEAI 434 Score = 57.4 bits (137), Expect = 3e-07 Identities = 36/113 (31%), Positives = 46/113 (40%), Gaps = 4/113 (3%) Query: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80 CG TL+ G SP +P GY +C W I +I + F S L YDY+ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 133 + DG R R G LP P+ ST S + S GF YE + Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434 Score = 57.0 bits (136), Expect = 3e-07 Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%) Query: 1194 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1251 L +C A CG + ++ G SP YP Y + C++ I V G+ I ++ + L + Sbjct: 316 LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374 Query: 1252 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308 D +++ DG + L G F G+ + + ST ++LW+EF S + +GF VY + Sbjct: 375 CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433 Query: 1309 F-------ELSHCEDPGIP 1320 + H + P P Sbjct: 434 ICGGDVKKDYGHIQSPNYP 452 Score = 55.1 bits (131), Expect = 1e-06 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%) Query: 1713 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1769 R L C A CG S G SP YP YS +CV+ I+V P E ++ F +++ Sbjct: 314 RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372 Query: 1770 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827 L +D VEV DG +++ L GS E + +S+ +++ + F S KGF VY Sbjct: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431 Query: 1828 QAV 1830 +A+ Sbjct: 432 EAI 434 Score = 54.7 bits (130), Expect = 2e-06 Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%) Query: 1365 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1424 Y P+C G +S+G SP YP Y ++ C+W I V PG + L F + D Sbjct: 317 YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371 Query: 1425 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1478 S +D + V DG L GS +PE I ST + + ++F + ++ K FA+ Sbjct: 372 SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430 Score = 45.1 bits (105), Expect = 0.001 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%) Query: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1082 CG ++ +G SP YP Y ++C W + VT G+ + NF + L +DY+ Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381 Query: 1083 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1120 + + PL R GS LP I ++ L+ FR+ ++ Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423 Score = 38.9 bits (89), Expect = 0.095 Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%) Query: 2416 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2470 CPA E DSTG SP YP+ Y C W ISV G I + + +D Sbjct: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378 Query: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530 ++V DG ++P+ G I S +++++ + KGF Y A C Sbjct: 379 YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436 Query: 2531 TPESPPHGYIIS 2542 +G+I S Sbjct: 437 GDVKKDYGHIQS 448 >gi|62739188 complement factor H isoform b precursor [Homo sapiens] Length = 449 Score = 134 bits (337), Expect = 2e-30 Identities = 128/460 (27%), Positives = 198/460 (43%), Gaps = 62/460 (13%) Query: 2887 MCKVVNCSDPGIPANSKRESKIEHGNF---TY--GTVVFYDCNPGYFLFGSSVLICQPNG 2941 +C +C++ +P +R ++I G++ TY GT Y C PGY G+ +++C+ G Sbjct: 15 ICVAEDCNE--LPP--RRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KG 69 Query: 2942 QWD--KPLPECIMIDCGHPGVPPNAVLS---GEKYTFGSTVHYSCTGKRSLLGQSS-RTC 2995 +W PL +C CGHPG P + G + +G Y+C LLG+ + R C Sbjct: 70 EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC 129 Query: 2996 QLNGHWSGSQPHCSGDATGTCGDPGTPGHGS------RQESNFRTKSTVRYACDTGYILH 3049 +G W+ P C C P +G + + VR+ C++GY + Sbjct: 130 DTDG-WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185 Query: 3050 GSEERTCLANGSWTGRQPECKAVQCGNP----GTTANGKVFRIDGTTFSSSVIYSCMEGY 3105 G EE C +G W+ +P+C + C +P G+ + K+ + F Y C GY Sbjct: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ----YKCNMGY 241 Query: 3106 ILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQP 3161 S CT +G W LP+C SC +P IP NG LR + G ++Y C+ Sbjct: 242 EYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI--KHRTGDEITYQCRN 296 Query: 3162 GYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF-------DWGFS 3214 G+ G+ + CT G W P C C P I +G L N G Sbjct: 297 GFYPATRGNTAK-CTSTG-WIPA-PRCTLKPCDY-PDIKHGGLYHENMRRPYFPVAVGKY 352 Query: 3215 ISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKSFIYQ 3270 SY C +E S+ + C +G WS VP CL K C P + + G+ F+ Sbjct: 353 YSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRK-CYFPYLENGYNQNHGRKFVQG 409 Query: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT 3310 + +C+ + L + T + + WS +P CI + T Sbjct: 410 KSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVSFT 448 Score = 120 bits (300), Expect = 3e-26 Identities = 122/458 (26%), Positives = 183/458 (39%), Gaps = 67/458 (14%) Query: 2587 CQAISCGIPKAPTNGGILTTD-----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2641 C A C N ILT Y GT+ Y C GYR + VC+ G W Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIM--VCRK-GEWV 72 Query: 2642 NHNKTPRCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI-E 2698 N +C C P F G + + G+ +EY K V++C+ GY LG + E Sbjct: 73 ALNPLRKCQKRPCGHPGDTPF----GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRE 128 Query: 2699 CLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGT------QTSYGSTAIFTCDLGFMLV 2752 C +G W N+ P C+++ C + P NG + + + +G F C+ G+ + Sbjct: 129 CDTDG---WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185 Query: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDT--VVYQCNPGFRLI 2810 G C G WS+ + +C+ C P+ ++NG I + Y++ Y+CN G+ Sbjct: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCNMGYEYS 244 Query: 2811 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSP--------IYGRTSGNGFNFNDVVTFSCN 2862 +C + W LPSC SC +P P I RT D +T+ C Sbjct: 245 ERGDAVCTES-GWR-PLPSCEEKSCDNPYIPNGDYSPLRIKHRT-------GDEITYQCR 295 Query: 2863 IGY--LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF--TYGTV 2918 G+ +G T A+C + W P P C + C P I + F G Sbjct: 296 NGFYPATRGNT-AKC-TSTGWI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKY 352 Query: 2919 VFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHP----GVPPNAVLSGEKY 2971 Y C+ + S + C +G W +P C+ C P G N G K+ Sbjct: 353 YSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR-KCYFPYLENGYNQN---HGRKF 406 Query: 2972 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHC 3008 G ++ +C G Q++ TC NG WS + P C Sbjct: 407 VQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRC 442 Score = 100 bits (248), Expect = 3e-20 Identities = 108/417 (25%), Positives = 155/417 (37%), Gaps = 82/417 (19%) Query: 3025 GSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQP--ECKAVQCGNPGTTAN 3082 GS + + + Y C GY G+ C G W P +C+ CG+PG T Sbjct: 35 GSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPF 93 Query: 3083 GKVFRIDGTTFSSSV--IYSCMEGYILSGP-SVRQCTANGTWSGTLPNCTIISCGDPGIP 3139 G G F V +Y+C EGY L G + R+C +G W+ +P C ++ C P Sbjct: 94 GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152 Query: 3140 ANG------LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTC 3193 NG + +Y GQ V ++C GY +E G C+ +G WS P C ++C Sbjct: 153 ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE--GDEEMHCSDDGFWSKEKPKCVEISC 210 Query: 3194 PTPPQISNGRL-EGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCG 3252 +P I+ + + + Y C+ GYE S C +G W +P C K C Sbjct: 211 KSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEKSCD 268 Query: 3253 DPGI------PAQGK-REGKSFIYQSEVSF-------------------------SCNFP 3280 +P I P + K R G YQ F C++P Sbjct: 269 NPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYP 328 Query: 3281 FILVGS-------------------STRICQADGTWSGS---SPHCIE-------PTQTS 3311 I G S + T SGS HC + P Sbjct: 329 DIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRK 388 Query: 3312 CENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLL-QGSTTRTCLPDLTWSGIQPECI 3367 C P + +QN+ F G + C G+ L + TT TC+ + WS P CI Sbjct: 389 CYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMEN-GWSP-TPRCI 443 Score = 99.8 bits (247), Expect = 5e-20 Identities = 119/456 (26%), Positives = 170/456 (37%), Gaps = 62/456 (13%) Query: 2714 CQIISCGELPTPPN-----GNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2768 C C ELP N G+ G+ AI+ C G+ +G+ + C G W Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74 Query: 2769 ET--RCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGS-SVRICQQDHN 2822 +C CG P G G + Y VY CN G++L+G + R C D Sbjct: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-G 133 Query: 2823 WSGQLPSCVPVSCGHPGSPIYGRTSGNG------FNFNDVVTFSCNIGYLMQGPTKAQCQ 2876 W+ +P C V C +P G+ + ++F V F CN GY ++G + C Sbjct: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193 Query: 2877 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKI---EHGNFTYGTVVFYDCNPGYFLFGSS 2933 + WS P C ++C P + S KI E+ F Y CN GY Sbjct: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ------YKCNMGYEYSERG 247 Query: 2934 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSC-TGKRSLLGQ 2990 +C +G W +PLP C C +P + PN S K+ G + Y C G Sbjct: 248 DAVCTESG-W-RPLPSCEEKSCDNPYI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304 Query: 2991 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR-------TKSTVRYACD 3043 ++ C G W + P C+ C P HG N R Y CD Sbjct: 305 NTAKCTSTG-WIPA-PRCT---LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCD 358 Query: 3044 TGYILHGS---EERTCLANGSWTGRQP---ECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3097 + + C +G W+ P +C N +G+ F + G S+ Sbjct: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRKF-VQG----KSI 412 Query: 3098 IYSCMEGYIL-SGPSVRQCTANGTWSGTLPNCTIIS 3132 +C GY L + C NG WS T P C +S Sbjct: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVS 446 Score = 94.7 bits (234), Expect = 1e-18 Identities = 89/352 (25%), Positives = 131/352 (37%), Gaps = 35/352 (9%) Query: 3095 SSVIYSCMEGYILSGPSVRQCTANGTWSGTLP--NCTIISCGDPGIPANG---LRYGDDY 3149 + IY C GY G + C G W P C CG PG G L G+ + Sbjct: 46 TQAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104 Query: 3150 VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGT-- 3207 G Y C GY + L R C +G W+ +P C V C NG++ + Sbjct: 105 EYGVKAVYTCNEGYQL-LGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162 Query: 3208 ----NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKRE 3263 + +G ++ ++C+ GY++ + C +G WS E P+C+ C P + G Sbjct: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV-INGSPI 221 Query: 3264 GKSFIYQSEVSFS--CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG 3321 + IY+ F CN + +C G W P C E SC+NP +P Sbjct: 222 SQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEK---SCDNPYIPNGD 276 Query: 3322 SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSG--IQPECIPHSCKQPETP-- 3377 + G + + C+ G TR T +G P C C P+ Sbjct: 277 YSPLRIKHRTGDEITYQCRNGFY---PATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHG 333 Query: 3378 --AHANVVGMDLP-SHGYTLIYTCQPGFFLAGGT--EHRVCRSDNTWTGKVP 3424 H N+ P + G Y C F G+ +H C D W+ VP Sbjct: 334 GLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP 384 Score = 90.9 bits (224), Expect = 2e-17 Identities = 115/429 (26%), Positives = 159/429 (37%), Gaps = 62/429 (14%) Query: 2554 WACDRGFRLVGKSSAVCRKSSYGYHAWDA--PVPACQAISCGIPKAPTNGGILTTD---Y 2608 + C G+R +G VCRK W A P+ CQ CG P G T + Sbjct: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104 Query: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWR 2668 G + Y CN+GY+L E+ C +DG W+ N P C VV C + + E+G + Sbjct: 105 EYGVKAVYTCNEGYQLLG-EINYRECDTDG-WT--NDIPICEVVKCLPVTA--PENG--K 156 Query: 2669 IVNGS-----HYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2723 IV+ + Y + V F C+ GY G + C +G WS E+P C ISC + P Sbjct: 157 IVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISC-KSP 213 Query: 2724 TPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPE 2781 NG+ I + Y F C++G+ C SG W + C C P Sbjct: 214 DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPS-CEEKSCDNP- 270 Query: 2782 LIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPG 2839 I NG +R D + YQC GF W P C C +P Sbjct: 271 YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDYPD 329 Query: 2840 SPIYGRTSGNGFNFNDVVTFSCNIG--YLMQGPTKAQCQANRQWSHPPPMCKVVNCS--- 2894 G N F +G Y + + W H ++C+ Sbjct: 330 IKHGGLYHENMRR----PYFPVAVGKYYSYYCDEHFETPSGSYWDH-------IHCTQDG 378 Query: 2895 -DPGIPANSK-------RESKIEHG-NFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWD 2944 P +P K HG F G + C+PGY L + + C NG W Sbjct: 379 WSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W- 436 Query: 2945 KPLPECIMI 2953 P P CI + Sbjct: 437 SPTPRCIRV 445 Score = 85.9 bits (211), Expect = 7e-16 Identities = 102/389 (26%), Positives = 152/389 (39%), Gaps = 60/389 (15%) Query: 2529 CSTPESPPHGYIISQTGGQLNSVVR--WACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2586 C P P G G V+ + C+ G++L+G+ + W +P Sbjct: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTNDIPI 140 Query: 2587 CQAISCGIPKAPTNGGILTT------DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2640 C+ + C AP NG I+++ +Y G V + CN GY++ E C DG W Sbjct: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE--EMHCSDDGFW 198 Query: 2641 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH------YEYKTKVVFSCDPGYHGLGP 2694 S + P+CV ++C S + ++NGS Y+ + + C+ GY Sbjct: 199 S--KEKPKCVEISCKSPD----------VINGSPISQKIIYKENERFQYKCNMGYEYSER 246 Query: 2695 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFM-L 2751 C +G WR P C+ SC + P PNG+ + + G + C GF Sbjct: 247 GDAVCTESG---WR-PLPSCEEKSC-DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPA 301 Query: 2752 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENY--GYRDTVV-----YQCN 2804 +C S+G W + RC C P+ I +G + EN Y V Y C+ Sbjct: 302 TRGNTAKCTSTG-WIPA-PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCD 358 Query: 2805 PGFRLIGSSV---RICQQDHNWSGQLPSCVPVSCGHPG-SPIYGRTSGNGFNFNDVVTFS 2860 F S C QD WS +P C+ C P Y + G F + + Sbjct: 359 EHFETPSGSYWDHIHCTQD-GWSPAVP-CLR-KCYFPYLENGYNQNHGRKFVQGKSIDVA 415 Query: 2861 CNIGY-LMQGPTKAQCQANRQWSHPPPMC 2888 C+ GY L + T C N WS P P C Sbjct: 416 CHPGYALPKAQTTVTCMEN-GWS-PTPRC 442 Score = 70.5 bits (171), Expect = 3e-11 Identities = 65/259 (25%), Positives = 99/259 (38%), Gaps = 24/259 (9%) Query: 3188 CRAVTCPTPP-----QISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGE 3242 C A C P +I G + G Y C PGY ++ C G W Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74 Query: 3243 VP--QCLPKFCGDPGIPAQGK---REGKSFIYQSEVSFSCNFPFILVGS-STRICQADGT 3296 P +C + CG PG G G F Y + ++CN + L+G + R C DG Sbjct: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG- 133 Query: 3297 WSGSSPHCIEPTQTSCENPGVPRHG-----SQNNTFGFQVGSVVQFHCKKGHLLQGSTTR 3351 W+ P C C P +G + + G V+F C G+ ++G Sbjct: 134 WTNDIPIC---EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190 Query: 3352 TCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR 3411 C D WS +P+C+ SCK P+ + + + Y C G+ + + Sbjct: 191 HCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGD-A 249 Query: 3412 VCRSDNTWTGKVPICEAGS 3430 VC +++ W +P CE S Sbjct: 250 VC-TESGWR-PLPSCEEKS 266 Score = 49.3 bits (116), Expect = 7e-05 Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%) Query: 3332 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP--ECIPHSCKQP-ETPAHA-NVVGMDL 3387 G+ + C+ G+ G+ C W + P +C C P +TP + G ++ Sbjct: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103 Query: 3388 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3437 +G +YTC G+ L G +R C +D WT +PICE + V P Sbjct: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152 Score = 42.4 bits (98), Expect = 0.009 Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 14/156 (8%) Query: 134 QSSSCGNPGVPPKGVLY---GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190 Q CG+PG P G G F+ G K Y+C GY L G +T W Sbjct: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTN 136 Query: 191 PVPICRAEDACGGTMRGSSGIISSPSFPN-EYHNNAD----CTWTIVAEPGDTISLIFTD 245 +PIC T + I+SS P+ EYH C E + + Sbjct: 137 DIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDG 196 Query: 246 FQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKN 281 F +EK +EI P I +G I II +N Sbjct: 197 FWSKEKPKCVEISCKSPDVI--NGSPISQKIIYKEN 230 Score = 41.6 bits (96), Expect = 0.015 Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%) Query: 2355 CQPPPPVPNAEILT---EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2401 C PP N EILT D + G Y+C PG+ +GN I+ CR GE Sbjct: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70 Score = 38.5 bits (88), Expect = 0.12 Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 28/273 (10%) Query: 1791 LSGSHSGESLPLSSGNQITIR----FTSVGPITA---KGFHFVYQAVPRTSSTQCSSVPE 1843 L+GS S ++ P G Q + + S+G + KG + + C + Sbjct: 33 LTGSWSDQTYP--EGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGD 90 Query: 1844 PRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIR-CETVPNSLAQWNDSLPTC-IVP 1898 FG GN F G ++ CN GY L G I R C+T W + +P C +V Sbjct: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVK 145 Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1958 C + G I+S + + + G I+ ++ + S + Sbjct: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205 Query: 1959 GDNNAPRLGSYSGTTIPHLLNSTSNNLY---LNFQSDISVSAAGFHLEYTAIGLDSCPEP 2015 + + +G+ I + N + N + S E L SC E Sbjct: 206 VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265 Query: 2016 QTPSSGIKIGD------RYMVGDVVSFQCDQGY 2042 + I GD ++ GD +++QC G+ Sbjct: 266 SCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF 298 Score = 38.1 bits (87), Expect = 0.16 Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 10/95 (10%) Query: 617 KEIEKESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 673 ++ +K CG PG +G + G+ F + C G++L+GE + + + W+ + Sbjct: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137 Query: 674 IPIC-IFPCLSNFTAP-----MGTVLSPDYPEGYG 702 IPIC + CL TAP + + + PD +G Sbjct: 138 IPICEVVKCLP-VTAPENGKIVSSAMEPDREYHFG 171 Score = 37.4 bits (85), Expect = 0.28 Identities = 13/39 (33%), Positives = 22/39 (56%) Query: 985 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023 ++ G V F C+SGY++ +E + C + +WS P C Sbjct: 167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205 Score = 37.4 bits (85), Expect = 0.28 Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 2/41 (4%) Query: 1158 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 + G + F C+SGY++EG E+ C G WS P+CV Sbjct: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206 Score = 35.8 bits (81), Expect = 0.80 Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 30/234 (12%) Query: 1327 SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE-CGGRFKGESSGR 1385 SDQ + G+ IY C PGY G+ ++ C GE A + PL C CG Sbjct: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PLRKCQKRPCGHPGDTPFGTF 96 Query: 1386 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWD-------GPPEN 1438 L+ G F Y ++ ++ + + + DT+ + + + + PEN Sbjct: 97 TLTGGNVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEN 154 Query: 1439 DMLLKEISGSLIPEGIHSTLNIV--------TIQFDTDFYISKSGF-AIQFSSSVATACR 1489 K +S ++ P+ + V I+ D + + S GF + + V +C+ Sbjct: 155 G---KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211 Query: 1490 DPGVPMNGTRNGDG--REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1541 P V +NG+ + + ++C+ GYE C + W+P P Sbjct: 212 SPDV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLP 260 Score = 35.0 bits (79), Expect = 1.4 Identities = 19/64 (29%), Positives = 27/64 (42%), Gaps = 9/64 (14%) Query: 1488 CRDPGVPMNGTRNGDGREP------GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1541 C P NG EP G V F C+ GY+++G+E + C + FW Sbjct: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC---SDDGFWSKEK 202 Query: 1542 PVCI 1545 P C+ Sbjct: 203 PKCV 206 Score = 34.3 bits (77), Expect = 2.3 Identities = 58/272 (21%), Positives = 94/272 (34%), Gaps = 50/272 (18%) Query: 1830 VPRTSSTQCSSVPEPRFGRRIGN------EFAVGSSVLFDCNPGYILHGSIAIRCETVPN 1883 +P +C V P G+ + + E+ G +V F CN GY + G + C + Sbjct: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----S 193 Query: 1884 SLAQWNDSLPTCI-VPCGGILTKRKGTILSPGYPEP----YDNNLNCVWKITVPEGAGIQ 1938 W+ P C+ + C K + G P Y N +K + G Sbjct: 194 DDGFWSKEKPKCVEISC-------KSPDVINGSPISQKIIYKENERFQYKCNM--GYEYS 244 Query: 1939 VQVVSFATEHNWDSLDFYDGGDNNAPRL--GSYSGTTIPHLLNSTSNNLYLNFQSDISVS 1996 + + TE W L + + P + G YS I H T + + ++ + Sbjct: 245 ERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKH---RTGDEITYQCRNGFYPA 301 Query: 1997 AAGFHLEYTAIG--------LDSCPEPQTPSSGIKIGDR------YMVGDVVSFQCDQGY 2042 G + T+ G L C P G+ + VG S+ CD+ + Sbjct: 302 TRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHF 361 Query: 2043 SLQGHS---HITCMPGPVRRWNYPIPICLAQC 2071 S HI C W+ +P CL +C Sbjct: 362 ETPSGSYWDHIHCTQD---GWSPAVP-CLRKC 389 Score = 32.3 bits (72), Expect = 8.9 Identities = 14/43 (32%), Positives = 23/43 (53%), Gaps = 4/43 (9%) Query: 1676 DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718 +Y G V + C++GY ++G + C DDG W++ P C Sbjct: 167 EYHFGQAVRFVCNSGYKIEGDEEMHC--SDDG--FWSKEKPKC 205 >gi|21264363 mannan-binding lectin serine protease 2 isoform 1 precursor [Homo sapiens] Length = 686 Score = 128 bits (322), Expect = 9e-29 Identities = 119/440 (27%), Positives = 186/440 (42%), Gaps = 68/440 (15%) Query: 2242 LCGGNITAMN--------GTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI 2293 LCG T + G + SPG+P EY N Q+ W + PPG + + FT E Sbjct: 10 LCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELS 69 Query: 2294 ----YDFITVWDGPDQNSPQIGQFSGNT----ALESVYSTSNQILIKFHSDFTTSGFFV- 2344 YDF+ + G + GQ S +T ++ YS + + I F SD++ F Sbjct: 70 HLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTG 129 Query: 2345 --LSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGER 2402 Y A + CQ P E T D + C +G +CR G Sbjct: 130 FEAFYAAEDIDECQVAP----GEAPTCD----------HHC---HNHLGGFYCSCRAGYV 172 Query: 2403 LQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITM-FVE 2461 L + C LC + ++ +G + SP YP YP L C +SIS+E+G+++ + FVE Sbjct: 173 LHRNKR--TCSALC-SGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVE 229 Query: 2462 FFQTEKEFDVLQVYDGPNIQSPVLISLSGDY---SSAFNITSNGHEVFLQWSADHGNNKK 2518 F E + L YD IQ+ G + + I + + V + + D + Sbjct: 230 SFDVETHPETLCPYDFLKIQTD--REEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHT 287 Query: 2519 GFRIRY--IAFYCSTPESPPHGYIIS-QTGGQLNSVVRWACDRGFRL------VGKSSAV 2569 G++I Y A C P +PP+G++ Q L C+ G+ L + +AV Sbjct: 288 GWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAV 347 Query: 2570 CRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVT-------YFCNDGY 2622 C+K +WD P+PAC + CG P +G + +Y+ G VT Y C + + Sbjct: 348 CQKDG----SWDRPMPACSIVDCGPPDDLPSGRV---EYITGPGVTTYKAVIQYSCEETF 400 Query: 2623 RLSSKELTTAVCQSDGTWSN 2642 VC++DG W++ Sbjct: 401 YTMKVNDGKYVCEADGFWTS 420 Score = 106 bits (265), Expect = 4e-22 Identities = 100/366 (27%), Positives = 157/366 (42%), Gaps = 52/366 (14%) Query: 1384 GRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASH----DILRVWDGPPEND 1439 GR+ SPG+P Y N+ W + PG + L F FD E SH D +++ G Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLA 87 Query: 1440 MLLKEISGSLI----PEGIHSTLNIVTIQFDTDFYISK--SGFAIQFSSSVATACR-DPG 1492 L + S + +S + + I F +D+ K +GF +++ C+ PG Sbjct: 88 TLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPG 147 Query: 1493 VPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNL 1552 + G C GY L +R C A C G + Sbjct: 148 EAPTCDHHCHNHLGG--FYCSCRAGYVLHRNKR-----------------TCSALCSGQV 188 Query: 1553 -TGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFI-SFSIEPN------YDFLYI 1604 T SG + SP +P PYP C ++I++ + + L F+ SF +E + YDFL I Sbjct: 189 FTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKI 248 Query: 1605 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1664 + + P G LP RIE+ SNT+ + F +D S +TG+ + Y + C P Sbjct: 249 QTDREEHGPFCG----KTLPHRIETKSNTVTITFVTDESGDHTGWKIHY-TSTAQPCPYP 303 Query: 1665 GNIMNG--TRLGMDYKLGSTVTYYCDAGY-VLQGY---STLTCIMGDDGRPGWNRALPSC 1718 NG + + Y L + + +C+ GY +LQG+ + T + DG W+R +P+C Sbjct: 304 MAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDG--SWDRPMPAC 361 Query: 1719 H-APCG 1723 CG Sbjct: 362 SIVDCG 367 Score = 103 bits (257), Expect = 3e-21 Identities = 103/377 (27%), Positives = 155/377 (41%), Gaps = 55/377 (14%) Query: 690 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE----SQFDFLAVKDGDSPES 745 G + SP +P Y N+ WT+ + PG R+ L F FDLE ++DF+ + G + Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83 Query: 746 PILGTFTGAE------VPSHLT--SNSHILRLEFQADHSMSG--RGFNITYNTFGHNECP 795 +L T G E P T S L + F++D+S GF Y +EC Sbjct: 84 KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143 Query: 796 -DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAP 854 PG N G S C G++ + T C A Sbjct: 144 VAPGEAPTCDHHCHNHLGGFYCS--CRAGYVLHRNKRT------------------CSAL 183 Query: 855 CGGH-FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITF-ERFQTELNYDVLEVH 912 C G F+ SG + SP +P Y +C + I E G S+ + F E F E + + L + Sbjct: 184 CSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPY 243 Query: 913 DGPNLLSPL--LGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 970 D + + G + G +P + + SN + + F TD S + G+KIHY T C Sbjct: 244 DFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHY---TSTAQPC 300 Query: 971 LDPGIPVHGR--RYGHDFSIGSTVSFSCDSGYRLSHEE-PL-----LCEKNHWWSHPLPT 1022 P P +G + + + S C++GY L PL +C+K+ W P+P Sbjct: 301 PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA 360 Query: 1023 CDAL-CGGDVRGPSGTI 1038 C + CG PSG + Sbjct: 361 CSIVDCGPPDDLPSGRV 377 Score = 100 bits (250), Expect = 2e-20 Identities = 93/381 (24%), Positives = 153/381 (40%), Gaps = 51/381 (13%) Query: 2080 GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH----DYLEVRSGSSETS 2135 G + SPGFPG Y + + WT+ P G+ + L F +F E H D++++ SG+ + Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLA 87 Query: 2136 TVIGRLS--GPQIP--SSLFSTTHETSLYFHSDYSQNK--QGFHIVYQAYQLQSC---PD 2186 T+ G+ S + P + +S + F SDYS K GF Y A + C P Sbjct: 88 TLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPG 147 Query: 2187 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2246 P T C + +G +C G + N C ALC G Sbjct: 148 EAP---------------TCDHHC---HNHLGGFYCSCRAGYVLHRNK--RTCSALCSGQ 187 Query: 2247 I-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTV---LQTEP----IYDFIT 2298 + T +G + SP YP YP C + + + G + ++F ++T P YDF+ Sbjct: 188 VFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLK 247 Query: 2299 VWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPP 2358 + +++ P F G T + + SN + I F +D + ++ + C P Sbjct: 248 IQTDREEHGP----FCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYP 303 Query: 2359 PPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGA----PPVCQV 2414 PN + ++ + D C G+ L+ + Q DG+ P C + Sbjct: 304 MAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSI 363 Query: 2415 L-C-PANELRLDSTGVILSPG 2433 + C P ++L I PG Sbjct: 364 VDCGPPDDLPSGRVEYITGPG 384 Score = 100 bits (248), Expect = 3e-20 Identities = 100/383 (26%), Positives = 166/383 (43%), Gaps = 57/383 (14%) Query: 851 CGA---PCGGHFSAPS-GVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN- 905 CG+ P G + P G + SPG+PG Y + W + A PG+ +++ F F EL+ Sbjct: 11 CGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSH 70 Query: 906 ---YDVLEVHDGPNLLSPLLG--SYNGTQVP--QFLFSSSNFIYLLFTTD--NSRSNNGF 956 YD +++ G +L+ L G S + + P +S + + + F +D N + GF Sbjct: 71 LCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGF 130 Query: 957 KIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWW 1016 + Y + ++ + PG + H+ G SC +GY L + Sbjct: 131 EAFYAAEDIDECQ-VAPGEAPTCDHHCHNHLGG--FYCSCRAGYVLHRNK---------- 177 Query: 1017 SHPLPTCDALCGGDV-RGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF-HTFHL 1074 TC ALC G V SG + SP YP YP +CT+++ + G V +F +F + Sbjct: 178 ----RTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDV 233 Query: 1075 EDH------HDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE 1128 E H +D+L I + P G LP I + + F++D S + Sbjct: 234 ETHPETLCPYDFLKIQTDREEHGPFC---GKTLPHRIET---KSNTVTITFVTDESGDHT 287 Query: 1129 GFNITFSEYNLEPCEDPGIPQYG--SRIGFNFGIGDTLTFSCSSGYR-LEG-----TSEI 1180 G+ I ++ +PC P P G S + + + D+ + C +GY L+G + Sbjct: 288 GWKIHYTS-TAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTA 346 Query: 1181 ICLGGGRRVWSAPLPRC-VAECG 1202 +C G W P+P C + +CG Sbjct: 347 VCQKDGS--WDRPMPACSIVDCG 367 Score = 98.2 bits (243), Expect = 1e-19 Identities = 95/368 (25%), Positives = 150/368 (40%), Gaps = 54/368 (14%) Query: 1731 GTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS--LL 1788 G + SP +P Y+ +++ P + + F F L + E YD S +L Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCE-YDFVKLSSGAKVL 86 Query: 1789 SSLSGSHSGES---------LPLSSGNQITIR--FTSVGPITAKGFHFVYQAVPRTSSTQ 1837 ++L G S ++ L S IT R +++ P T GF Y A + Sbjct: 87 ATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFT--GFEAFYAA---EDIDE 141 Query: 1838 CSSVP--EPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1895 C P P N C GY+LH + TC Sbjct: 142 CQVAPGEAPTCDHHCHNHLG---GFYCSCRAGYVLHRNKR------------------TC 180 Query: 1896 IVPCGG-ILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSL 1953 C G + T+R G + SP YP PY +C + I++ EG + + V SF E + ++L Sbjct: 181 SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL 240 Query: 1954 DFYD--GGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDS 2011 YD + G + G T+PH + + SN + + F +D S G+ + YT+ Sbjct: 241 CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTA-QP 299 Query: 2012 CPEPQTPSSG--IKIGDRYMVGDVVSFQCDQGYS-LQGHSHITCMPGPVRR---WNYPIP 2065 CP P P +G + +Y++ D S C+ GY LQGH + ++ W+ P+P Sbjct: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359 Query: 2066 IC-LAQCG 2072 C + CG Sbjct: 360 ACSIVDCG 367 Score = 92.0 bits (227), Expect = 9e-18 Identities = 96/362 (26%), Positives = 150/362 (41%), Gaps = 47/362 (12%) Query: 1908 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLDFYDGGDNNA 1963 G + SPG+P Y N+ W +T P G +++ F E + +D + G A Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLA 87 Query: 1964 PRLGSYSGTTI----PHLLNSTSNNLYLNFQSDISVSA--AGFHLEYTAIGLDSCPEPQT 2017 G S T S ++L + F+SD S GF Y A +D C Q Sbjct: 88 TLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC---QV 144 Query: 2018 PSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAM-S 2076 D + + F C +C G V N C A C G + + Sbjct: 145 APGEAPTCDHHCHNHLGGFYC------------SCRAGYVLHRNKRT--CSALCSGQVFT 190 Query: 2077 DFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFV-NFSTET------IHDYLEVRS 2129 SG + SP +P YP CT++I+L GF V L FV +F ET +D+L++++ Sbjct: 191 QRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQT 250 Query: 2130 GSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRP 2189 E G G +P + + ++ ++ F +D S + G+ I Y + Q CP P Sbjct: 251 DREEH----GPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS-TAQPCPYPMA 305 Query: 2190 FRNGFV--IGNDFTVGQTISFECFPGYTLI-GNSALTCLHGVSR---NWNHPLPRCEAL- 2242 NG V + + + + S C GY L+ G+ L V + +W+ P+P C + Sbjct: 306 PPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVD 365 Query: 2243 CG 2244 CG Sbjct: 366 CG 367 Score = 86.3 bits (212), Expect = 5e-16 Identities = 96/365 (26%), Positives = 148/365 (40%), Gaps = 50/365 (13%) Query: 1210 GILLSPNYPLNYENNHECIYSIQVQAGKGINISARTF-----HLAQGDVLKIYDGKDKTT 1264 G L SP +P Y N+ E +++ G + + F HL + D +K+ G Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLA 87 Query: 1265 HLLGAFTGASMRGL---TLSSTSNQLWLEFNSD--TEGTDEGFQLVYTSFELSHCE-DPG 1318 L G + + R T S + L + F SD E GF+ Y + ++ C+ PG Sbjct: 88 TLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPG 147 Query: 1319 -IPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGR 1377 P + + H G C GY LH + +C A C G+ Sbjct: 148 EAPTCDHHCHN--HLGG--FYCSCRAGYVLHRNKR----------------TCSALCSGQ 187 Query: 1378 FKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFL-AFDTE------ASHDILR 1430 + SG + SP YP PY C + I ++ G V L F+ +FD E +D L+ Sbjct: 188 VFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLK 247 Query: 1431 VWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRD 1490 + E+ G +P I + N VTI F TD +G+ I ++S+ A C Sbjct: 248 IQTDREEHG----PFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTST-AQPCPY 302 Query: 1491 PGVPMNGTRNGDGRE--PGDTVVFQCDPGYE-LQGE---ERITCIQVENRYFWQPSPPVC 1544 P P NG + + D+ C+ GYE LQG + T + ++ + +P P Sbjct: 303 PMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACS 362 Query: 1545 IAPCG 1549 I CG Sbjct: 363 IVDCG 367 Score = 79.0 bits (193), Expect = 8e-14 Identities = 98/388 (25%), Positives = 149/388 (38%), Gaps = 57/388 (14%) Query: 517 GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIG----YDTLTIGDGGEV- 571 G SP FP +Y ++ + W +TA + +++ F FDLE+ YD + + G +V Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYR-LRLYFTHFDLELSHLCEYDFVKLSSGAKVL 86 Query: 572 ----GDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGS--VGFKVNYKEIEKESCG 625 G T + G D S+ S + + ++D S GF+ Y + + C Sbjct: 87 ATLCGQESTDTERAPGK---DTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143 Query: 626 -DPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSN 684 PG D + + F C C+ N C C Sbjct: 144 VAPGE----APTCDHHCHNHLGGFYCS------------CRAGYVLHRNKRTCSALCSGQ 187 Query: 685 -FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSF-NDFDLESQ------FDFLA 736 FT G + SP+YP Y +C ++I + G + L F FD+E+ +DFL Sbjct: 188 VFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLK 247 Query: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPD 796 ++ P F G +P + + S+ + + F D S G+ I Y T CP Sbjct: 248 IQTDREEHGP----FCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHY-TSTAQPCPY 302 Query: 797 PGIPINAR--RFGDNFQLGSSISVICEEGFIKTQG---TETITCILM-DGKVMWSGLIPK 850 P P N + L S S+ CE G+ QG ++ T + DG W +P Sbjct: 303 PMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGS--WDRPMPA 360 Query: 851 CG-APCGGHFSAPSG---VILSPGWPGY 874 C CG PSG I PG Y Sbjct: 361 CSIVDCGPPDDLPSGRVEYITGPGVTTY 388 Score = 79.0 bits (193), Expect = 8e-14 Identities = 101/372 (27%), Positives = 152/372 (40%), Gaps = 60/372 (16%) Query: 1557 GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYIYDGPDSNS 1612 G + SP FP Y + ++ WT+T Y + L F F +E + YDF+ + G + Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLA 87 Query: 1613 PLIGSFQDSKLPERIE------SSSNTMHLAFRSDGSVS--YTGFHLEYKAKLRESCFDP 1664 L G Q+S ER S +++ + FRSD S +TGF Y A+ + C Sbjct: 88 TLCG--QESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC--- 142 Query: 1665 GNIMNGTRLGMDYKLGSTVT-YYCD--AGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP 1721 + G D+ + + +YC AGYVL +R +C A Sbjct: 143 -QVAPGEAPTCDHHCHNHLGGFYCSCRAGYVL------------------HRNKRTCSAL 183 Query: 1722 C-GSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV-FFQTSLH-DVVEVY 1778 C G T G + SP YP+ Y +C YSI++ + F V FV F H + + Y Sbjct: 184 CSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPY 243 Query: 1779 DGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTS--VGPITAKGFHFVYQAVPRT 1833 D Q+ G G++LP + N +TI F + G T H+ A P Sbjct: 244 DFLKIQTD--REEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQP-- 299 Query: 1834 SSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGY-ILHGSIAIRCET-VPNSLAQWN 1889 C P G + ++ + S C GY +L G + ++ T V W+ Sbjct: 300 ----CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWD 355 Query: 1890 DSLPTC-IVPCG 1900 +P C IV CG Sbjct: 356 RPMPACSIVDCG 367 Score = 77.8 bits (190), Expect = 2e-13 Identities = 97/368 (26%), Positives = 144/368 (39%), Gaps = 56/368 (15%) Query: 1036 GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHH----DYLLITENGSFTQ 1091 G + SPG+P Y N WT+ G ++ F F LE H D++ ++ S + Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLS---SGAK 84 Query: 1092 PLARLTGSDLPPTINAGLYGNFRA-----QLRFISDFSIS--YEGFNITFSEYNLEPCE- 1143 LA L G + T A F + + F SD+S + GF ++ +++ C+ Sbjct: 85 VLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQV 144 Query: 1144 DPG-IPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC- 1201 PG P + G SC +GY L C A C Sbjct: 145 APGEAPTCDHHCHNHLG---GFYCSCRAGYVLHRNKRT----------------CSALCS 185 Query: 1202 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAG--------KGINISARTFHLAQGDV 1253 G T G L SP YP Y C YSI ++ G + ++ L D Sbjct: 186 GQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDF 245 Query: 1254 LKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313 LKI D+ H G F G ++ + + SN + + F +D G G+++ YTS Sbjct: 246 LKIQ--TDREEH--GPFCGKTLPH-RIETKSNTVTITFVTDESGDHTGWKIHYTS-TAQP 299 Query: 1314 CEDPGIPQFGYKISDQG-HFAGSTIIYGCNPGY-TLHGSSLLKCMTG---ERRAWDYPLP 1368 C P P G+ Q + + C GY L G LK T + +WD P+P Sbjct: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359 Query: 1369 SC-IAECG 1375 +C I +CG Sbjct: 360 ACSIVDCG 367 Score = 64.3 bits (155), Expect = 2e-09 Identities = 75/291 (25%), Positives = 113/291 (38%), Gaps = 39/291 (13%) Query: 34 GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLSLYDGHPH-P 88 G + SPGFP Y N W + A R+++ F F LE EYD++ L G Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLA 87 Query: 89 TNFRTRLTGFHLPP---PVTSTKSVFSLRLTSDFAVSAH--GFKVYYEELQSSSCG-NPG 142 T T P S S + SD++ GF+ +Y C PG Sbjct: 88 TLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPG 147 Query: 143 VPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACG 202 P + G SC GY+L + + TC A +C G Sbjct: 148 EAPTCDHHCHNHLGG--FYCSCRAGYVLHRNKR-TCSA-------------LCS-----G 186 Query: 203 GTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTD-FQMEE------KYDYL 255 SG +SSP +P Y + CT++I E G ++ L F + F +E YD+L Sbjct: 187 QVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFL 246 Query: 256 EIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSS 306 +I+ G +P I + N + + FVTD + + G+ Y ++ Sbjct: 247 KIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTA 297 Score = 63.5 bits (153), Expect = 4e-09 Identities = 85/340 (25%), Positives = 130/340 (38%), Gaps = 47/340 (13%) Query: 33 NGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVF-QSFALEEEYDYLSLYDGHPHPTNF 91 +G + SP +P YP ++CT+ I EE + + F +SF +E + L YD T+ Sbjct: 193 SGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDR 252 Query: 92 RTR--LTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVL 149 G LP + + + ++ +D + G+K++Y + C P PP G + Sbjct: 253 EEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS-TAQPCPYPMAPPNGHV 311 Query: 150 --YGTRFDVGDKIRYSCVTGY-ILDGH-PQLTCIANSVNTASWDFPVPICRAEDACGGTM 205 ++ + D C TGY +L GH P + A SWD P+P C D CG Sbjct: 312 SPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVD-CGPPD 370 Query: 206 RGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGS----E 261 SG + EY + PG T + EE + +++ E Sbjct: 371 DLPSGRV-------EY----------ITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCE 413 Query: 262 PPTIWLS-----GMNIPPPIISNKNWLRLHFVTDSNHRYRGFSA-----PYQGSSTLTHT 311 W S + + P+ L T Y G A P+Q L T Sbjct: 414 ADGFWTSSKGEKSLPVCEPVCG------LSARTTGGRIYGGQKAKPGDFPWQ-VLILGGT 466 Query: 312 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLS 351 T+ G L N T A AV D + + T+ RLS Sbjct: 467 TAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLS 506 Score = 60.5 bits (145), Expect = 3e-08 Identities = 59/203 (29%), Positives = 80/203 (39%), Gaps = 38/203 (18%) Query: 3009 SGDATG----------TCGDPGTP--GHGSRQESNFRTKSTVRYACDTGY-ILHG----- 3050 SGD TG C P P GH S ++ + K + C+TGY +L G Sbjct: 283 SGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLK 342 Query: 3051 SEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDG---TTFSSSVIYSCMEGY-- 3105 S C +GSW P C V CG P +G+V I G TT+ + + YSC E + Sbjct: 343 SFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYT 402 Query: 3106 --ILSGPSVRQCTANGTWSG-----TLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYM 3158 + G V C A+G W+ +LP C + CG G YG GQ Sbjct: 403 MKVNDGKYV--CEADGFWTSSKGEKSLPVCEPV-CGLSARTTGGRIYG-----GQKAKPG 454 Query: 3159 CQPGYTMELNGSRIRTCTINGTW 3181 P + L G+ + W Sbjct: 455 DFPWQVLILGGTTAAGALLYDNW 477 Score = 57.8 bits (138), Expect = 2e-07 Identities = 59/251 (23%), Positives = 93/251 (37%), Gaps = 27/251 (10%) Query: 499 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEI 558 ++ C G SG +SP +P Y + C + I+ VI E FD+E Sbjct: 176 NKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVET 235 Query: 559 GYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKE 618 +TL D ++ R G +P I + S+ + + TDES G+K++Y Sbjct: 236 HPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS 295 Query: 619 IEKESCGDPGTPLYG--IREGDGFSNRDVLRFECQFGFEL------IGEKSIVCQENNQW 670 + C P P G + +D C+ G+EL + + VCQ++ W Sbjct: 296 -TAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSW 354 Query: 671 SANIPIC-IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE 729 +P C I C P G V I+ PG + + + E Sbjct: 355 DRPMPACSIVDCGPPDDLPSGRV-----------------EYITGPGVTTYKAVIQYSCE 397 Query: 730 SQFDFLAVKDG 740 F + V DG Sbjct: 398 ETFYTMKVNDG 408 Score = 53.9 bits (128), Expect = 3e-06 Identities = 40/137 (29%), Positives = 58/137 (42%), Gaps = 16/137 (11%) Query: 2835 CGHPGSPIYGRTSGNGFNF--NDVVTFSCNIGY-LMQG--PTK---AQCQANRQWSHPPP 2886 C +P +P G S + D + C GY L+QG P K A CQ + W P P Sbjct: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359 Query: 2887 MCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLF--GSSVLICQPNGQW- 2943 C +V+C P + + E G TY V+ Y C ++ +C+ +G W Sbjct: 360 ACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWT 419 Query: 2944 ----DKPLPECIMIDCG 2956 +K LP C + CG Sbjct: 420 SSKGEKSLPVCEPV-CG 435 Score = 53.5 bits (127), Expect = 4e-06 Identities = 25/91 (27%), Positives = 43/91 (47%), Gaps = 6/91 (6%) Query: 2921 YDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNA----VLSGEKYTFGST 2976 Y+ G+ S +CQ +G WD+P+P C ++DCG P P+ + T+ + Sbjct: 332 YELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAV 391 Query: 2977 VHYSC--TGKRSLLGQSSRTCQLNGHWSGSQ 3005 + YSC T + C+ +G W+ S+ Sbjct: 392 IQYSCEETFYTMKVNDGKYVCEADGFWTSSK 422 Score = 50.8 bits (120), Expect = 2e-05 Identities = 45/158 (28%), Positives = 61/158 (38%), Gaps = 23/158 (14%) Query: 3187 TCRAVTCPTPPQISNGRLEGTNFDWGF--SISYICSPGYEL--------SFPAVLTCVGN 3236 T A CP P NG + + S S C GYEL SF AV C + Sbjct: 294 TSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAV--CQKD 351 Query: 3237 GTWSGEVPQCLPKFCGDPGIPAQGKREGKS----FIYQSEVSFSCNFPF--ILVGSSTRI 3290 G+W +P C CG P G+ E + Y++ + +SC F + V + Sbjct: 352 GSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYV 411 Query: 3291 CQADGTWSGSS-----PHCIEPTQTSCENPGVPRHGSQ 3323 C+ADG W+ S P C S G +G Q Sbjct: 412 CEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQ 449 Score = 48.5 bits (114), Expect = 1e-04 Identities = 38/157 (24%), Positives = 65/157 (41%), Gaps = 27/157 (17%) Query: 3071 AVQCGNPGTTANGKVFRI-------DGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSG 3123 A C P NG V + D + Y ++G++ C +G+W Sbjct: 297 AQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDR 356 Query: 3124 TLPNCTIISCGDP-GIPANGLRYGDDYVVGQNVS-------YMCQPG-YTMELNGSRIRT 3174 +P C+I+ CG P +P+ + +Y+ G V+ Y C+ YTM++N + Sbjct: 357 PMPACSIVDCGPPDDLPSGRV----EYITGPGVTTYKAVIQYSCEETFYTMKVNDGKY-V 411 Query: 3175 CTINGTWSG-----VMPTCRAVTCPTPPQISNGRLEG 3206 C +G W+ +P C V C + + GR+ G Sbjct: 412 CEADGFWTSSKGEKSLPVCEPV-CGLSARTTGGRIYG 447 Score = 43.9 bits (102), Expect = 0.003 Identities = 90/430 (20%), Positives = 148/430 (34%), Gaps = 76/430 (17%) Query: 2427 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQS 2482 G + SPG+P Y N Q W+++ GY + ++ F E E+D +++ G + + Sbjct: 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLA 87 Query: 2483 PVLISLSGDYSSA---FNITSNGHEVFLQWSADHGNNKK--GFRIRYIAFYCSTPESPP- 2536 + S D A S G + + + +D+ N K GF Y A + P Sbjct: 88 TLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPG 147 Query: 2537 -----HGYIISQTGGQLNSVVRWACDRGFRLVGKS---SAVCRKSSYGYHAWDA-----P 2583 + + GG S C G+ L SA+C + + + P Sbjct: 148 EAPTCDHHCHNHLGGFYCS-----CRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYP 202 Query: 2584 VPACQAISCGIPKAPTNGGILTTDYL----VGTRVTYFCNDGYRL--SSKELTTAVCQSD 2637 P + SC + G + D++ V T C + + +E C Sbjct: 203 RPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFC--- 259 Query: 2638 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRI-------------------VNGSHYEYK 2678 G H + VT + +H W+I V+ +Y Sbjct: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYI 319 Query: 2679 TKVVFS--CDPGYH------GLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNK 2730 K FS C+ GY L + C +G SW P C I+ CG P+G Sbjct: 320 LKDSFSIFCETGYELLQGHLPLKSFTAVCQKDG--SWDRPMPACSIVDCGPPDDLPSGRV 377 Query: 2731 IGTQ----TSYGSTAIFTCDLGF--MLVGSAVRECLSSGLWSESETR----CLAGHCGIP 2780 T+Y + ++C+ F M V C + G W+ S+ CG+ Sbjct: 378 EYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLS 437 Query: 2781 ELIVNGQVIG 2790 G++ G Sbjct: 438 ARTTGGRIYG 447 Score = 43.5 bits (101), Expect = 0.004 Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 19/134 (14%) Query: 2777 CGIPELIVNGQV--IGENYGYRDTVVYQCNPGFRLIG------SSVRICQQDHNWSGQLP 2828 C P NG V + Y +D+ C G+ L+ S +CQ+D +W +P Sbjct: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359 Query: 2829 SCVPVSCGHPGSPIYGRT---SGNGF-NFNDVVTFSCNIGY--LMQGPTKAQCQANRQWS 2882 +C V CG P GR +G G + V+ +SC + + K C+A+ W+ Sbjct: 360 ACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWT 419 Query: 2883 HPP-----PMCKVV 2891 P+C+ V Sbjct: 420 SSKGEKSLPVCEPV 433 Score = 43.1 bits (100), Expect = 0.005 Identities = 41/151 (27%), Positives = 62/151 (41%), Gaps = 23/151 (15%) Query: 2955 CGHPGVPPNAVLSG--EKYTFGSTVHYSC-TGKRSLLGQS-----SRTCQLNGHWSGSQP 3006 C +P PPN +S KY + C TG L G + CQ +G W P Sbjct: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359 Query: 3007 HCSGDATGTCGDPGTPGHGSRQ----ESNFRTKSTVRYAC-DTGYILHGSEER-TCLANG 3060 CS CG P G + K+ ++Y+C +T Y + ++ + C A+G Sbjct: 360 ACS---IVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADG 416 Query: 3061 SWTGRQ-----PECKAVQCGNPGTTANGKVF 3086 WT + P C+ V CG T G+++ Sbjct: 417 FWTSSKGEKSLPVCEPV-CGLSARTTGGRIY 446 Score = 40.0 bits (92), Expect = 0.043 Identities = 26/108 (24%), Positives = 43/108 (39%), Gaps = 9/108 (8%) Query: 3329 FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV---VGM 3385 F + + +GHL S T C D +W P C C P+ V G Sbjct: 324 FSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGP 383 Query: 3386 DLPSHGYTLIYTCQPGFFLAGGTEHR-VCRSDNTWTG-----KVPICE 3427 + ++ + Y+C+ F+ + + VC +D WT +P+CE Sbjct: 384 GVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCE 431 >gi|13899255 membrane frizzled-related protein [Homo sapiens] Length = 579 Score = 125 bits (313), Expect = 1e-27 Identities = 93/302 (30%), Positives = 133/302 (44%), Gaps = 40/302 (13%) Query: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSL-DFYD 1957 CGG+L+ +G SP YP+PY N +CVW I V IQ+++ + + E L D + Sbjct: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203 Query: 1958 GGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI--GLDSCPEP 2015 L G P LN+ +++L + F SD SV GFH Y A+ G SC Sbjct: 204 LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263 Query: 2016 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS----HITCMPGPVRRWNYPIPICLAQ- 2070 + F+CDQ L S C G C A+ Sbjct: 264 E-------------------FRCDQLICLLPDSVCDGFANCADGSDET------NCSAKF 298 Query: 2071 --CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124 CGG ++ G +P + YP L CTW I++P G + LQF NFS E DY Sbjct: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358 Query: 2125 LEV-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2183 +EV + SS +++GR G + P L S+ HE ++ F +D+ + GF Y A+ Sbjct: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418 Query: 2184 CP 2185 P Sbjct: 419 NP 420 Score = 117 bits (293), Expect = 2e-25 Identities = 95/306 (31%), Positives = 131/306 (42%), Gaps = 45/306 (14%) Query: 507 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 562 TCG L GP G F+SPN+P Y N CVW I V T+ IQ+ E +E +D Sbjct: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHI-QVATDHAIQLKIEALSIESVASCLFDR 201 Query: 563 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE-- 620 L + +P L + G P + + +S + + +D SV GF Y+ + Sbjct: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256 Query: 621 KESCG------DPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANI 674 + SC D L DGF+N C G + N Sbjct: 257 RGSCAHDEFRCDQLICLLPDSVCDGFAN-------CADGSD---------------ETNC 294 Query: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ--- 731 C N T GT +P Y + Y + L C W I G I L F++F LE+Q Sbjct: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354 Query: 732 -FDFLAVKDGDSPES-PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF 789 FD++ V + S + +LG F GAE P HL S+ H L + F+ DH +S GF+ TY F Sbjct: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414 Query: 790 GHNECP 795 E P Sbjct: 415 NATENP 420 Score = 108 bits (271), Expect = 7e-23 Identities = 98/349 (28%), Positives = 147/349 (42%), Gaps = 45/349 (12%) Query: 813 GSSISVICEEGFIKTQGTETITCILMDGKVMW---SGLIPKCGAPCGGHFSAPSGVILSP 869 G+S S + G T T TIT G SG+ P + CGG S P G SP Sbjct: 99 GASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSP 158 Query: 870 GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSY 925 +P Y + +C W I+ H+I++ E E +D LE+ P PLL Sbjct: 159 NYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPE--GPLL-RV 215 Query: 926 NGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD 985 G P L ++++ + ++F +D+S GF Y+++ SC HD Sbjct: 216 CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC------------AHD 263 Query: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL---CGGDVRGPSGTILSPG 1042 F CD L + N C A CGG++ G GT +P Sbjct: 264 -------EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316 Query: 1043 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITE---NGSFTQPLAR 1095 Y + YP+ L CTW + V G ++ FH F LE DY+ + E +G+F+ L R Sbjct: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL-LGR 375 Query: 1096 LTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNL--EPC 1142 G++ PP + + + + F +D IS GF+ T+ +N PC Sbjct: 376 FCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYLAFNATENPC 421 Score = 99.8 bits (247), Expect = 5e-20 Identities = 84/308 (27%), Positives = 125/308 (40%), Gaps = 38/308 (12%) Query: 24 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 79 TCGG L G G SP +P YP +C W I + IQ+ ++ ++E +D L Sbjct: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202 Query: 80 SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139 L P P R+ G PP + + S + SD +V GF +Y+ + Sbjct: 203 EL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM------ 253 Query: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE- 198 P +G F I + + DG ++ N C A+ Sbjct: 254 ---APGRGSCAHDEFRCDQLI--CLLPDSVCDGFANCADGSDETN----------CSAKF 298 Query: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDY 254 CGG + G G S+PS+ +Y + CTW I G +I L F +F +E K+DY Sbjct: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358 Query: 255 LEI-EGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309 +E+ E S L G PP ++S+ + L + F TD GFSA Y + Sbjct: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418 Query: 310 HTTSTGEL 317 + EL Sbjct: 419 NPCGPSEL 426 Score = 99.0 bits (245), Expect = 8e-20 Identities = 84/305 (27%), Positives = 126/305 (41%), Gaps = 42/305 (13%) Query: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLA 736 C + P G SP+YP+ Y N +C+W I I L +ES FD L Sbjct: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203 Query: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF--GHNEC 794 + PE P+L P+ T+ SH+L + F +D S+ G GF+ Y G C Sbjct: 204 L--SPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSC 260 Query: 795 PDPGIPINARRFGDNFQLGSSISVICE---EGFIK-TQGTETITCILMDGKVMWSGLIPK 850 D F+ I ++ + +GF G++ C +SG Sbjct: 261 AH-----------DEFRCDQLICLLPDSVCDGFANCADGSDETNC-----SAKFSG---- 300 Query: 851 CGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF----QTELNY 906 CGG+ + G +P + Y L C W I GHSI++ F F Q E + Sbjct: 301 ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356 Query: 907 DVLEVHD-GPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTV 965 D +EV++ + LLG + G + P L SS + + +LF TD+ S+ GF Y + Sbjct: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416 Query: 966 NTYSC 970 C Sbjct: 417 TENPC 421 Score = 93.6 bits (231), Expect = 3e-18 Identities = 90/310 (29%), Positives = 134/310 (43%), Gaps = 41/310 (13%) Query: 1539 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN 1598 PSP + CGG L+G GF SPN+P PYP + C W I V D+ I L + SIE Sbjct: 138 PSPQ---STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESV 194 Query: 1599 YDFLY--IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1656 L+ + P+ PL+ P + ++++ + + F SD SV GFH Y+A Sbjct: 195 ASCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA- 252 Query: 1657 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716 PG G+ +++ + D+ V G++ C G D Sbjct: 253 -----MAPG---RGSCAHDEFRCDQLICLLPDS--VCDGFA--NCADGSDE--------T 292 Query: 1717 SCHAP---CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLH- 1772 +C A CG TG +GT +P+Y + Y C + I+VP + QF F Sbjct: 293 NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQD 352 Query: 1773 ----DVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHF 1825 D VEVY+ SS SL G G P +SS +++ + F + I++ GF Sbjct: 353 ECKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409 Query: 1826 VYQAVPRTSS 1835 Y A T + Sbjct: 410 TYLAFNATEN 419 Score = 89.4 bits (220), Expect = 6e-17 Identities = 90/334 (26%), Positives = 138/334 (41%), Gaps = 43/334 (12%) Query: 2237 PRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYD- 2295 P ++ CGG ++ G SP YPD YP C W ++V + I + L E + Sbjct: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197 Query: 2296 -FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRV 2354 F + P+ P + + G ++ + ++ +L+ F SD + GF +HA+ Sbjct: 198 LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250 Query: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV-CQ 2413 Q P + DEF +I LP G A C DG+ C Sbjct: 251 -QAMAPGRGS---CAHDEFRCDQLICL--LPDSVCDGFA--NCA-------DGSDETNCS 295 Query: 2414 VL---CPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF----QTE 2466 C N L G +P Y YP+ +C W ISV G++I + F Q E Sbjct: 296 AKFSGCGGNLTGLQ--GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353 Query: 2467 KEFDVLQVYDGPNIQSPVLISLSGDYSSAF---NITSNGHEVFLQWSADHGNNKKGFRIR 2523 +FD ++VY+ S SL G + A ++ S+ HE+ + + DHG + GF Sbjct: 354 CKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410 Query: 2524 YIAFYCSTPESPPHGYIISQTGGQLNSVVRWACD 2557 Y+AF + P + Q GG V+W CD Sbjct: 411 YLAFNATENPCGP-SELSCQAGGCKG--VQWMCD 441 Score = 77.8 bits (190), Expect = 2e-13 Identities = 74/300 (24%), Positives = 115/300 (38%), Gaps = 34/300 (11%) Query: 1021 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1080 P+ + CGG + GP G SP YP+ YP + +C W + V +Q +E Sbjct: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197 Query: 1081 LL--ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138 L + + PL R+ G PPT+N + F+SD S+ GF+ + Sbjct: 198 LFDRLELSPEPEGPLLRVCGRVPPPTLNTNA---SHLLVVFVSDSSVEGFGFHAWYQAM- 253 Query: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198 P GS F + S +C G + C Sbjct: 254 --------APGRGSCAHDEFRCDQLICLLPDS----------VCDGFANCADGSDETNCS 295 Query: 1199 AE---CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1250 A+ CG + T +G +P+Y Y + C + I V AG I + F L + Sbjct: 296 AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355 Query: 1251 GDVLKIYD-GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSF 1309 D +++Y+ LLG F GA L S+ ++L + F +D + GF Y +F Sbjct: 356 FDYVEVYETSSSGAFSLLGRFCGAEPPP-HLVSSHHELAVLFRTDHGISSGGFSATYLAF 414 Score = 62.0 bits (149), Expect = 1e-08 Identities = 39/136 (28%), Positives = 62/136 (45%), Gaps = 7/136 (5%) Query: 14 DRQTASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALE 73 D S CGG L GL GT +P + YP+ CTW I + I++ F +F+LE Sbjct: 290 DETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE 349 Query: 74 EE----YDYLSLYD-GHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV 128 + +DY+ +Y+ + R G PP + S+ ++ +D +S+ GF Sbjct: 350 AQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409 Query: 129 YYEELQSSSCGNPGVP 144 Y L ++ NP P Sbjct: 410 TY--LAFNATENPCGP 423 Score = 61.6 bits (148), Expect = 1e-08 Identities = 74/306 (24%), Positives = 114/306 (37%), Gaps = 40/306 (13%) Query: 1195 PRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVL 1254 P + CG + G SPNYP Y N C++ IQV I + + + Sbjct: 138 PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196 Query: 1255 KIYDGKDKTTHLLGAFTGASMR--GLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELS 1312 ++D + + G R TL++ ++ L + F SD+ GF Y + Sbjct: 197 CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA-- 254 Query: 1313 HCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLL----KCMTGERRAWDYPLP 1368 P G D+ + C+ L S+ C G Sbjct: 255 -------PGRGSCAHDE---------FRCDQLICLLPDSVCDGFANCADGSDET------ 292 Query: 1369 SCIAE---CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA- 1424 +C A+ CGG G G +P Y Y + L C W I V G+ + LQF F EA Sbjct: 293 NCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQ 351 Query: 1425 ---SHDILRVWDGPPENDM-LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1480 D + V++ LL G+ P + S+ + + + F TD IS GF+ + Sbjct: 352 DECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411 Query: 1481 SSSVAT 1486 + AT Sbjct: 412 LAFNAT 417 Score = 57.8 bits (138), Expect = 2e-07 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 5/111 (4%) Query: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253 + CGG + G G SSP++P+ Y N C W I I L +E +D Sbjct: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200 Query: 254 YLEIEGS-EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303 LE+ E P + + G PP + +N + L + FV+DS+ GF A YQ Sbjct: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ 251 Score = 52.4 bits (124), Expect = 8e-06 Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 8/152 (5%) Query: 469 QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQY 528 +F CD+ L C A + K CG NL G GTF++P++ QY Sbjct: 264 EFRCDQLICL--LPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQY 321 Query: 529 DSNAQCVWVITAVNTNKVIQINFEEFDL----EIGYDTLTIGDGGEVGDPRTVLQVLTGS 584 C W I +V I++ F F L E +D + + + G ++L G+ Sbjct: 322 PHQLLCTWHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGA 379 Query: 585 FVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 616 P +VS ++ + +TD + S GF Y Sbjct: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411 Score = 36.2 bits (82), Expect = 0.61 Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 8/86 (9%) Query: 2404 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2463 Q G P Q C L G SP YPD YP C W I V + I + +E Sbjct: 132 QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189 Query: 2464 QTEKE----FDVLQVYDGPNIQSPVL 2485 E FD L++ P + P+L Sbjct: 190 SIESVASCLFDRLEL--SPEPEGPLL 213 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.137 0.440 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 170,028,648 Number of Sequences: 37866 Number of extensions: 8921449 Number of successful extensions: 34129 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 140 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 17175 Number of HSP's gapped (non-prelim): 6472 length of query: 3667 length of database: 18,247,518 effective HSP length: 122 effective length of query: 3545 effective length of database: 13,627,866 effective search space: 48310784970 effective search space used: 48310784970 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.