BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|34734079 frizzled 6 [Homo sapiens] (706 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|34734079 frizzled 6 [Homo sapiens] 1457 0.0 gi|8393378 frizzled 3 [Homo sapiens] 684 0.0 gi|4503827 frizzled 2 [Homo sapiens] 461 e-130 gi|4503825 frizzled 1 [Homo sapiens] 461 e-129 gi|4503833 frizzled 7 [Homo sapiens] 458 e-129 gi|6005762 frizzled 10 [Homo sapiens] 368 e-101 gi|27894385 frizzled 5 precursor [Homo sapiens] 353 4e-97 gi|4503835 frizzled 9 [Homo sapiens] 350 3e-96 gi|22547161 frizzled 4 [Homo sapiens] 315 9e-86 gi|13994190 frizzled 8 [Homo sapiens] 262 7e-70 gi|5032099 smoothened [Homo sapiens] 163 6e-40 gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] 89 1e-17 gi|38455388 frizzled-related protein [Homo sapiens] 86 9e-17 gi|29244926 corin [Homo sapiens] 82 1e-15 gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] 81 4e-15 gi|48475052 secreted frizzled-related protein 2 precursor [Homo ... 80 8e-15 gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] 75 3e-13 gi|13899255 membrane frizzled-related protein [Homo sapiens] 70 5e-12 gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] 64 5e-10 gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] 64 5e-10 gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 51 3e-06 gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 48 3e-05 gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 47 8e-05 gi|163792198 latrophilin 3 precursor [Homo sapiens] 43 9e-04 gi|45433552 G protein-coupled receptor 133 [Homo sapiens] 42 0.001 gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens] 42 0.003 gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo sapi... 42 0.003 gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho... 37 0.063 gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens] 35 0.18 gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens] 35 0.18 >gi|34734079 frizzled 6 [Homo sapiens] Length = 706 Score = 1457 bits (3771), Expect = 0.0 Identities = 706/706 (100%), Positives = 706/706 (100%) Query: 1 MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH 60 MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH Sbjct: 1 MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH 60 Query: 61 FLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEE 120 FLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEE Sbjct: 61 FLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEE 120 Query: 121 LECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQ 180 LECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQ Sbjct: 121 LECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQ 180 Query: 181 CAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVC 240 CAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVC Sbjct: 181 CAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVC 240 Query: 241 YSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWW 300 YSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWW Sbjct: 241 YSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWW 300 Query: 301 VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVG 360 VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVG Sbjct: 301 VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVG 360 Query: 361 LYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF 420 LYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF Sbjct: 361 LYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF 420 Query: 421 SGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKY 480 SGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKY Sbjct: 421 SGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKY 480 Query: 481 LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHK 540 LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHK Sbjct: 481 LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHK 540 Query: 541 KKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV 600 KKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV Sbjct: 541 KKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV 600 Query: 601 KADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITD 660 KADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITD Sbjct: 601 KADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITD 660 Query: 661 TGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT 706 TGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT Sbjct: 661 TGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT 706 >gi|8393378 frizzled 3 [Homo sapiens] Length = 666 Score = 684 bits (1766), Expect = 0.0 Identities = 344/633 (54%), Positives = 419/633 (66%), Gaps = 27/633 (4%) Query: 3 MFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFL 62 +F+ +F+ + GHSLF+CEPIT+ C + YN TF PNL+ HYDQ AA+ ME F Sbjct: 7 VFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFH 66 Query: 63 PLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELE 122 P+ NL+CS + FLC + P C+E V PCR+LC++ YS+C KL++ FG+ WPE++E Sbjct: 67 PMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDME 126 Query: 123 CDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCA 182 C R CDE P D + + VQRD GFWCPR LK GY FL + C+ Sbjct: 127 CSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCS 186 Query: 183 PPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYS 242 PPCPNMYF+ +EL FA+ FIG +SI CL ATLFTFLTFLIDV RFRYPERPII+Y+VCY Sbjct: 187 PPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYM 246 Query: 243 IVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVI 302 +VSL++FIGFLL D ACN + TV GS NKACT+LFM+LYFFTMAG+VWWVI Sbjct: 247 MVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVI 306 Query: 303 LTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLY 362 LTITWFLAA KW EAIE+KA+ FHA AWG PG LT++LLAMNK+EGDNISGVCFVGLY Sbjct: 307 LTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLY 366 Query: 363 DLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSG 422 D+DA RYFVL PLCL V VG+SLLLAGIISLN VR I + NQ+KL KFMIRIGVFS Sbjct: 367 DVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSI 426 Query: 423 LYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLM 482 LYLVPL+ ++GCY YEQ R WE TW+ + CR+YHIPCPYQ +RP+L LF++KYLM Sbjct: 427 LYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLM 486 Query: 483 TLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQES--CEFFLKHNSKVKHK 540 LIVGI +VFWVGSKKTC EWA FF RK++ ++ESR+VLQE + L+ Sbjct: 487 ALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLR-------- 538 Query: 541 KKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV 600 +I KS GTST T+ H +S D + + S Sbjct: 539 -------DPNTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHR 591 Query: 601 KADGASTPRLREQDCG----EPASPAASISRLS 629 DG TP C E P S+SRL+ Sbjct: 592 SRDGRYTP------CSYRGMEERLPHGSMSRLT 618 >gi|4503827 frizzled 2 [Homo sapiens] Length = 565 Score = 461 bits (1187), Expect = e-130 Identities = 225/517 (43%), Positives = 308/517 (59%), Gaps = 32/517 (6%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83 C+PI++P C +AYN T PNL+GH +Q A +E+ F PL ++CSP + FLC + P Sbjct: 39 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98 Query: 84 TCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEF 143 C +PPCR +CE+ C+ L++ FG +WPE L C+ H+E Sbjct: 99 VCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSED 158 Query: 144 LGPQKKTEQ----VQRDIG---------------------FWCPRHLKTSGGQGYKFLGI 178 P T +Q G F CPR LK YKFLG Sbjct: 159 GAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGE 218 Query: 179 DQCAPPCP------NMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPER 232 CA PC +M+F +E FA+ +I T S+ C +T FT T+L+D++RFRYPER Sbjct: 219 RDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPER 278 Query: 233 PIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFF 292 PII+ S CY++VS+ Y GF+L + CN+ + + TVV G++ + CT+LFM+LYFF Sbjct: 279 PIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSE-DGYRTVVQGTKKEGCTILFMMLYFF 337 Query: 293 TMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDN 352 +MA ++WWVIL++TWFLAAG KW EAIE + +FH AW P T+ +LAM +++GD Sbjct: 338 SMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDL 397 Query: 353 ISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKK 412 +SGVCFVGL LD R FVL PL + +F+G S LLAG +SL +R +++HDG EKL++ Sbjct: 398 LSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLER 457 Query: 413 FMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPE 472 M+RIGVFS LY VP ++ CY YEQ R WE +WVS HC+ IPCP + P+ Sbjct: 458 LMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPD 517 Query: 473 LALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509 ++MIKYLMTLIVGI++ FW+ S KT W F+ R Sbjct: 518 FTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTR 554 >gi|4503825 frizzled 1 [Homo sapiens] Length = 647 Score = 461 bits (1186), Expect = e-129 Identities = 233/523 (44%), Positives = 315/523 (60%), Gaps = 39/523 (7%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83 C+PI++P C +AYN T PNL+GH +Q A +E+ F PL ++CS ++ FLC + P Sbjct: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175 Query: 84 TCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRL------QYCDETVPVTF 137 C +PPCR LCE+ C+ L++ FG +WP+ L+C++ + C Sbjct: 176 VCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK 235 Query: 138 DPHTEFLGPQKKTEQVQRDIG-----------------FWCPRHLKTSGGQGYKFLGIDQ 180 T L P+ T Q G F CPR LK Y FLG Sbjct: 236 GTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKD 295 Query: 181 CAPPCPN------MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPI 234 C PC MYF +EL F++++IG S+ C +TLFT LT+L+D+RRF YPERPI Sbjct: 296 CGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPI 355 Query: 235 IYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGD-TVVLGSQNKACTVLFMLLYFFT 293 I+ S CY+ V++ Y GFLL D CN D+ E G TV G++ + CT+LFM+LYFF+ Sbjct: 356 IFLSGCYTAVAVAYIAGFLLEDRVVCN--DKFAEDGARTVAQGTKKEGCTILFMMLYFFS 413 Query: 294 MAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNI 353 MA ++WWVIL++TWFLAAG KW EAIE + +FH AW P T+ +LA+ +V+GD + Sbjct: 414 MASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVL 473 Query: 354 SGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKF 413 SGVCFVGL ++DA R FVL PL + +F+G S LLAG +SL +R +++HDG EKL+K Sbjct: 474 SGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKL 533 Query: 414 MIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPY-QAKAKA--- 469 M+RIGVFS LY VP ++ CY YEQ R WE +WV+ C+ Y IPCP+ QA A Sbjct: 534 MVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPH 593 Query: 470 ---RPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509 P+ +FMIKYLMTLIVGI++ FW+ S KT W F+ R Sbjct: 594 PPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTR 636 >gi|4503833 frizzled 7 [Homo sapiens] Length = 574 Score = 458 bits (1178), Expect = e-129 Identities = 227/518 (43%), Positives = 305/518 (58%), Gaps = 35/518 (6%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83 C+PI++P C +AYN T PNL+GH +Q A +E+ F PL ++CSP + FLC + P Sbjct: 49 CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108 Query: 84 TCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRL------QYCD------- 130 C +PPCR LCE+ C+ L++ FG +WPE L C+ + C Sbjct: 109 VCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDG 168 Query: 131 -----------ETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGID 179 T P D L P + + F CPR LK GY+FLG Sbjct: 169 SGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGER 228 Query: 180 QCAPPCPN------MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERP 233 C PC MYFK +E FA+ ++G S+ C +TLFT LT+L+D+RRF YPERP Sbjct: 229 DCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERP 288 Query: 234 IIYYSVCYSIVSLMYFIGFLLGDSTACNK--ADEKLELGDTVVLGSQNKACTVLFMLLYF 291 II+ S CY +V++ + GFLL D C + +D+ TV G++ + CT+LFM+LYF Sbjct: 289 IIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYR---TVAQGTKKEGCTILFMVLYF 345 Query: 292 FTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGD 351 F MA ++WWVIL++TWFLAAG KW EAIE + +FH AW P T+ +LAM +V+GD Sbjct: 346 FGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGD 405 Query: 352 NISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLK 411 +SGVC+VGL +DA R FVL PL + +F+G S LLAG +SL +R +++HDG EKL+ Sbjct: 406 LLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLE 465 Query: 412 KFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARP 471 K M+RIGVFS LY VP +L CY YEQ R WE TW+ C+ Y +PCP P Sbjct: 466 KLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSP 525 Query: 472 ELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509 + +FMIKYLMT+IVGI+ FW+ S KT W F+ R Sbjct: 526 DFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHR 563 >gi|6005762 frizzled 10 [Homo sapiens] Length = 581 Score = 368 bits (944), Expect = e-101 Identities = 193/555 (34%), Positives = 307/555 (55%), Gaps = 44/555 (7%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83 C+PI +P C + YNMT PNLMGH +Q AA+++ F PL C ++ FLC + P Sbjct: 34 CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93 Query: 84 TCIEQIHV-VPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTE 142 C EQ+ +P CR +CE+ C +++ F +WP+ L+C +L P DP+ Sbjct: 94 MCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKL-------PNKNDPNYL 146 Query: 143 FL-GPQKKTEQVQRDIGFWCP-----------RHLKTSGGQGY-------KFLGIDQ--- 180 + P +++ R G + P H GG G KF +++ Sbjct: 147 CMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSAS 206 Query: 181 CAPPCP---NMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYY 237 CAP C ++Y+ ++ FA ++ ++ C ++ FT LTFLID RFRYPERPII+ Sbjct: 207 CAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFL 266 Query: 238 SVCYSIVSLMYFIGFLLG-DSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAG 296 S+CY + S+ Y I G +S AC++ +L + + G ++ CT++F++LY+F MA Sbjct: 267 SMCYCVYSVGYLIRLFAGAESIACDRDSGQLYV---IQEGLESTGCTLVFLVLYYFGMAS 323 Query: 297 TVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGV 356 ++WWV+LT+TWFLAAG+KW EAIE + +FH AW P T+++L M +V GD ++GV Sbjct: 324 SLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGV 383 Query: 357 CFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIR 416 C+VG D++A FVL+PL + +G S +L+G ++L H+R+V++ G N +KL+K M+R Sbjct: 384 CYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVR 443 Query: 417 IGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYH----IPCPYQAKAKARPE 472 IG+FS LY VP ++ CY YE++N W+I C+ + + C A + P Sbjct: 444 IGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDC---LMAASIPA 500 Query: 473 LALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLK 532 + +FM+K M L+VGI++ W+ + KT W R K+ + V+ + Sbjct: 501 VEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKA 560 Query: 533 HNSKVKHKKKHYKPS 547 + + H K+ P+ Sbjct: 561 QHPQKTHHGKYEIPA 575 >gi|27894385 frizzled 5 precursor [Homo sapiens] Length = 585 Score = 353 bits (905), Expect = 4e-97 Identities = 199/525 (37%), Positives = 275/525 (52%), Gaps = 60/525 (11%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83 C+ ITVP C + YN+T PN H Q A +E+ F PL ++CSP++ FLC + P Sbjct: 33 CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTP 92 Query: 84 TCIEQIHV-VPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPV------- 135 C+ H +PPCR +CE+ + C L+ +G WPE + CDRL V Sbjct: 93 ICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNR 152 Query: 136 ---TFDPHTEFLGPQKKT-----------EQVQRDIGFWC--------------PRHLKT 167 T P F P K T + F C P + K Sbjct: 153 SEATTAPPRPF--PAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKV 210 Query: 168 SGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRF 227 GQ + CA PC F +DE FA +IG S+ C +T T TFLID+ RF Sbjct: 211 RTGQ------VPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERF 264 Query: 228 RYPERPIIYYSVCYSIVSLMYFIGFLLGD-STACNKADEKLELGDTVVLGSQNKACTVLF 286 RYPERPII+ S CY VSL + + ++G S AC++ + T CT++F Sbjct: 265 RYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETT-----GPALCTIVF 319 Query: 287 MLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMN 346 +L+YFF MA ++WWVIL++TWFLAAG KW EAI A +FH AW P ++ LA++ Sbjct: 320 LLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALS 379 Query: 347 KVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRN 406 V+GD ++G+C+VG +L++ R FVL PL L + VG LLAG +SL +R VI+ G Sbjct: 380 SVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTK 439 Query: 407 QEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQ-- 464 +KL+K MIRIG+F+ LY VP ++ CY+YEQ R +WE CP Sbjct: 440 TDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALT--------CACPGHDT 491 Query: 465 AKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509 + +A+PE + M+KY M L+VGI++ W+ S KT W F R Sbjct: 492 GQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSR 536 >gi|4503835 frizzled 9 [Homo sapiens] Length = 591 Score = 350 bits (898), Expect = 3e-96 Identities = 193/525 (36%), Positives = 286/525 (54%), Gaps = 57/525 (10%) Query: 17 RGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETF 76 RG C+ + +P C + YN+T PNL+GH Q AA E+ F PL C ++ F Sbjct: 32 RGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFF 91 Query: 77 LCKAFVPTCIEQIHV-VPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPV 135 LC + P C +Q+ +P CR +CE+ C +++ F WP+ L+C RL P Sbjct: 92 LCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARL-------PT 144 Query: 136 TFDPHTEFL-GPQKKTE---QVQRDIGFW--CPRHLKTSGGQG------------YKFLG 177 DPH + P+ T + + +G PR + G G KF Sbjct: 145 RNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQY 204 Query: 178 IDQ---CAPPCP---NMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPE 231 +++ CAP C +++ + +FA ++ S C +T FT LTFL++ RF+YPE Sbjct: 205 VEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPE 264 Query: 232 RPIIYYSVCYSIVSLMYFIGFLLG-DSTACNKADEKLELGDTVVL--GSQNKACTVLFML 288 RPII+ S+CY++ SL + I + G S AC++ E G V+ G +N CT++F+L Sbjct: 265 RPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQ-----EAGALYVIQEGLENTGCTLVFLL 319 Query: 289 LYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKV 348 LY+F MA ++WWV+LT+TWFLAAG+KW EAIE +FH AWG P T+++L + KV Sbjct: 320 LYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKV 379 Query: 349 EGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQE 408 GD ++G+C+V D A FVL+PL + +G S LL G ++L H+R++++ G N E Sbjct: 380 AGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTE 439 Query: 409 KLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAK 468 KL+K M++IGVFS LY VP ++ CYVYE++N W + R PC A Sbjct: 440 KLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRL-------RATEQPCAAAAGPG 492 Query: 469 AR----------PELALFMIKYLMTLIVGISAVFWVGSKKTCTEW 503 R P +A+FM+K M+L+VGI++ WV S KT W Sbjct: 493 GRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTW 537 >gi|22547161 frizzled 4 [Homo sapiens] Length = 537 Score = 315 bits (807), Expect = 9e-86 Identities = 178/495 (35%), Positives = 261/495 (52%), Gaps = 50/495 (10%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83 C+PI + C + YN+T PNL+GH Q+ A +++ F PL CS ++ FLC +VP Sbjct: 45 CDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVP 104 Query: 84 TCIEQIHV-VPPCRKLCEKVYSDCKKLIDTFGIRWPEELEC-------DRLQYC-----D 130 C E+I++ + PC +C V C+ ++ FG WPE L C D C D Sbjct: 105 MCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGD 164 Query: 131 ETVPVTFDPHTEFLGPQKKTEQV--QRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNM 188 E VP+ PH + P ++ V D W R L GY + Sbjct: 165 EEVPL---PHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYD-----------AGL 210 Query: 189 YFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMY 248 Y +S + EF ++ + C +T FT LTFLID RF YPERPII+ S+CY+I S+ Y Sbjct: 211 YSRSAK-EFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAY 269 Query: 249 FIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWF 308 + +G +E E + G +N C ++F+L+YFF MA ++WWVILT+TWF Sbjct: 270 IVRLTVGRERISCDFEEAAE-PVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWF 328 Query: 309 LAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASR 368 LAAG KW EAIE + +FH AW P T+++L M V+ D ++G+C+VG +LDA Sbjct: 329 LAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALT 388 Query: 369 YFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPL 428 FV+ PL + +G + AG+++L +R +Q DG +KL++ M++IGVFS LY VP Sbjct: 389 GFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPA 448 Query: 429 VTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGI 488 ++ CY YE N W + Y A +A+ M+K M+L+VGI Sbjct: 449 TCVIACYFYEISN---WAL-------------FRYSADDS---NMAVEMLKIFMSLLVGI 489 Query: 489 SAVFWVGSKKTCTEW 503 ++ W+ S KT W Sbjct: 490 TSGMWIWSAKTLHTW 504 >gi|13994190 frizzled 8 [Homo sapiens] Length = 694 Score = 262 bits (670), Expect = 7e-70 Identities = 149/371 (40%), Positives = 203/371 (54%), Gaps = 47/371 (12%) Query: 178 IDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYY 237 I CA PC N +F DE F +IG S+ C +T T TFLID+ RF+YPERPII+ Sbjct: 257 IANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFL 316 Query: 238 SVCYSIVSLMYFIGFLLG-DSTACNK------------------------ADEKLELGDT 272 S CY VS+ Y + + G + AC+ A G+ Sbjct: 317 SACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEY 376 Query: 273 VVLGSQNK----------ACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQ 322 LG+ + CTV+F+L+YFF MA ++WWVIL++TWFLAAG KW EAI Sbjct: 377 EELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAG 436 Query: 323 KAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVG 382 + +FH AW P ++ +LA++ V+GD ++G+C+VG LD R FVL PL + +F+G Sbjct: 437 YSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIG 496 Query: 383 LSLLLAGIISLNHVRQVI-QHDGRNQ-EKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQV 440 LLAG +SL +R VI Q DG + KL+K MIR+G+F+ LY VP ++ C YEQ Sbjct: 497 TMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQH 556 Query: 441 NRITWEITWVSDHCRQYHIPC--PYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKK 498 NR WE T ++ PC Q RP+ A+FM+KY M L+VGI++ WV S K Sbjct: 557 NRPRWEAT--------HNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGK 608 Query: 499 TCTEWAGFFKR 509 T W R Sbjct: 609 TLESWRSLCTR 619 Score = 103 bits (258), Expect = 4e-22 Identities = 42/104 (40%), Positives = 62/104 (59%), Gaps = 1/104 (0%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83 C+ ITVP C + YN T+ PN H Q A +E+ F PL ++CSP+++ FLC + P Sbjct: 35 CQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTP 94 Query: 84 TCIEQI-HVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRL 126 C+E +PPCR +CE+ + C L+ +G WP+ + CDRL Sbjct: 95 ICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRL 138 >gi|5032099 smoothened [Homo sapiens] Length = 787 Score = 163 bits (412), Expect = 6e-40 Identities = 125/453 (27%), Positives = 203/453 (44%), Gaps = 43/453 (9%) Query: 69 CSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQY 128 C I+ LC ++P C E V P R LC+ C + G WP+ L C Sbjct: 118 CWAVIQPLLCAVYMPKC-ENDRVELPSRTLCQATRGPCAIVERERG--WPDFLRC----- 169 Query: 129 CDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNM 188 T D E G + + ++ + C L + + ++ C C N Sbjct: 170 -------TPDRFPE--GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNP 220 Query: 189 YFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRF-RYPERPIIYYSVCYSIVSLM 247 F E + S+I TLFT TF+ D R RYP + Y + C+ + S+ Sbjct: 221 LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIG 280 Query: 248 YFIGFLLGD--STACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTI 305 + F+ G C +AD + LG+ ++ +C ++F+++Y+ MAG VW+V+LT Sbjct: 281 WLAQFMDGARREIVC-RADGTMRLGEPT--SNETLSCVIIFVIVYYALMAGVVWFVVLTY 337 Query: 306 TW---FLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLY 362 W F A G + + + K +FH + W P LTV +LA+ +V+GD++SG+CFVG Sbjct: 338 AWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYK 395 Query: 363 DLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQE----KLKKFMIRIG 418 + FVL P+ L + VG L+ G+++L ++ H G E K+ + M+R+G Sbjct: 396 NYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLG 453 Query: 419 VFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHI--------PCPYQAKAKAR 470 +F L ++ C+ Y+ N+ WE ++ Q ++ P P + K R Sbjct: 454 IFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIP-DCEIKNR 512 Query: 471 PELALFMIKYLMTLIVGISAVFWVGSKKTCTEW 503 P L + I GI+ WV +K T W Sbjct: 513 PSLLVEKINLFAMFGTGIAMSTWVWTKATLLIW 545 >gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] Length = 346 Score = 89.0 bits (219), Expect = 1e-17 Identities = 45/138 (32%), Positives = 72/138 (52%), Gaps = 4/138 (2%) Query: 3 MFTFLLT--CIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH 60 MF +L C++L L G CE + +P C M +N+T PN + H Q A + +E Sbjct: 1 MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQ 60 Query: 61 FLPLANLECSPNIETFLCKAFVPTC-IEQIH-VVPPCRKLCEKVYSDCKKLIDTFGIRWP 118 + L ++ CS + FLC + P C +E +H + PC+ +C++ DC+ L+ + WP Sbjct: 61 YEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWP 120 Query: 119 EELECDRLQYCDETVPVT 136 E L CD L D V ++ Sbjct: 121 ESLACDELPVYDRGVCIS 138 >gi|38455388 frizzled-related protein [Homo sapiens] Length = 325 Score = 86.3 bits (212), Expect = 9e-17 Identities = 45/134 (33%), Positives = 67/134 (50%), Gaps = 4/134 (2%) Query: 7 LLTCIFLPLLR--GHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPL 64 LL L LLR G CEP+ +P C + +NMT PN + H Q+ A + +E F L Sbjct: 16 LLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGL 75 Query: 65 ANLECSPNIETFLCKAFVPTCI--EQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELE 122 CSP++ FLC + P C Q + PC+ +CE+ C+ ++ + WPE L Sbjct: 76 LGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLA 135 Query: 123 CDRLQYCDETVPVT 136 C+ L D V ++ Sbjct: 136 CEELPVYDRGVCIS 149 >gi|29244926 corin [Homo sapiens] Length = 1042 Score = 82.4 bits (202), Expect = 1e-15 Identities = 47/151 (31%), Positives = 66/151 (43%), Gaps = 17/151 (11%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH--FLPLANLECSPNIETFLCKAF 81 CEPIT+ CM + YN T +PN GH Q A++ E F L C + F C Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514 Query: 82 VPTC-IEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPH 140 VP C + +PPCR LCE C+ ++ G++WPE+ +C + P + Sbjct: 515 VPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQF-------PEENSDN 567 Query: 141 TEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQ 171 L P + E+ P H K GQ Sbjct: 568 QTCLMPDEYVEECS-------PSHFKCRSGQ 591 Score = 55.5 bits (132), Expect = 2e-07 Identities = 38/129 (29%), Positives = 54/129 (41%), Gaps = 15/129 (11%) Query: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLP----LANLECSPNIETFLCK 79 C IT +C + Y+ T P L + +EME FL L L C +I F C Sbjct: 139 CMNITHSQCQMLPYHATLTPLL-----SVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCT 193 Query: 80 AFVPTCI---EQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVT 136 P CI + H + PCR CE C+ ++ WP+ L C + + E+ V+ Sbjct: 194 LAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVS 253 Query: 137 ---FDPHTE 142 F P E Sbjct: 254 RICFSPQQE 262 >gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] Length = 314 Score = 80.9 bits (198), Expect = 4e-15 Identities = 40/125 (32%), Positives = 59/125 (47%), Gaps = 2/125 (1%) Query: 26 PITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTC 85 P + C + Y PNL+ H + + ++PL N C + FLC F P C Sbjct: 62 PADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVC 121 Query: 86 IEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLG 145 +++ + PCR LCE V C+ ++ FG WPE L+CD+ D + +T TE Sbjct: 122 LDR--PIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASK 179 Query: 146 PQKKT 150 PQ T Sbjct: 180 PQGTT 184 >gi|48475052 secreted frizzled-related protein 2 precursor [Homo sapiens] Length = 295 Score = 79.7 bits (195), Expect = 8e-15 Identities = 39/121 (32%), Positives = 59/121 (48%), Gaps = 4/121 (3%) Query: 24 CEPI--TVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAF 81 C+PI + C + Y PNL+GH + ++PL +C P+ + FLC F Sbjct: 40 CKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLF 99 Query: 82 VPTCIEQI-HVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRL-QYCDETVPVTFDP 139 P C++ + + PC LC +V C ++ FG WP+ LECDR Q D +P+ Sbjct: 100 APVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSD 159 Query: 140 H 140 H Sbjct: 160 H 160 >gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] Length = 317 Score = 74.7 bits (182), Expect = 3e-13 Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 2/100 (2%) Query: 26 PITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTC 85 P +P C + Y PNL+ H + + +LPL C + + FLC F P C Sbjct: 57 PADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC 116 Query: 86 IEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDR 125 +++ + PCR LCE V + C L++ +G WPE L C + Sbjct: 117 LDR--PIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHK 154 >gi|13899255 membrane frizzled-related protein [Homo sapiens] Length = 579 Score = 70.5 bits (171), Expect = 5e-12 Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 3/104 (2%) Query: 24 CEPITVPRCMKMAYNMTFFPNL-MGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFV 82 CEP+ V C+ ++YN T FPN+ +G Q + + L +L C + LC V Sbjct: 466 CEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLV 525 Query: 83 PTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRL 126 P C V+PPCR +C++ C+ + G WP C+RL Sbjct: 526 PRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRL 567 >gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] Length = 641 Score = 63.9 bits (154), Expect = 5e-10 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 6/108 (5%) Query: 23 TCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFL-----PLANLECSPNIETFL 77 TC + + C AYN T FPNL+ H + E+ L L +C+P++ Sbjct: 31 TCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLG 90 Query: 78 CKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDR 125 C P C E V PCR +CE + C+ D + WP L+C R Sbjct: 91 CAVLAPRC-EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHR 137 >gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] Length = 652 Score = 63.9 bits (154), Expect = 5e-10 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 6/108 (5%) Query: 23 TCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFL-----PLANLECSPNIETFL 77 TC + + C AYN T FPNL+ H + E+ L L +C+P++ Sbjct: 42 TCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLG 101 Query: 78 CKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDR 125 C P C E V PCR +CE + C+ D + WP L+C R Sbjct: 102 CAVLAPRC-EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHR 148 >gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo sapiens] Length = 1584 Score = 51.2 bits (121), Expect = 3e-06 Identities = 55/246 (22%), Positives = 101/246 (41%), Gaps = 39/246 (15%) Query: 192 SDELEFAKSFIGTVSIFCLCA----TLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLM 247 S + K+ + +V++ C TL + + V R+ ER +I + C SI+S Sbjct: 936 SADANMEKATLPSVTLIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSN 995 Query: 248 YFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITW 307 I L+G + NK CT++ L+FF ++ W +LT W Sbjct: 996 ALI--LIGQTQTRNKV-----------------VCTLVAAFLHFFFLSSFCW--VLTEAW 1034 Query: 308 --FLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLD 365 ++A I ++ F + WG P + + + K +G + C++ L Sbjct: 1035 QSYMAVTGHLRNRLIRKR---FLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLE--G 1089 Query: 366 ASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYL 425 Y + P V V ++ GI+ N +++ DG +KLK+ ++S + Sbjct: 1090 GLLYAFVGPAAAVVLVN---MVIGILVFN---KLVSKDGITDKKLKE-RAGASLWSSCVV 1142 Query: 426 VPLVTL 431 +PL+ L Sbjct: 1143 LPLLAL 1148 >gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] Length = 1585 Score = 48.1 bits (113), Expect = 3e-05 Identities = 49/204 (24%), Positives = 81/204 (39%), Gaps = 34/204 (16%) Query: 211 CATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELG 270 C L T L RF ER II + C SI++ I L+G S +K Sbjct: 944 CMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILI--LVGQSRVLSKG------- 994 Query: 271 DTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITW--FLAAGRKWSCEAIEQKAVWFH 328 CT+ L+FF ++ W +LT W +LA + + ++ F Sbjct: 995 ----------VCTMTAAFLHFFFLSSFCW--VLTEAWQSYLAVIGRMRTRLVRKR---FL 1039 Query: 329 AVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLA 388 + WG P + + + + +G S C++ L Y + P + V V +L Sbjct: 1040 CLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLE--GGLLYAFVGPAAVIVLVN---MLI 1094 Query: 389 GIISLNHVRQVIQHDGRNQEKLKK 412 GII N +++ DG + + K+ Sbjct: 1095 GIIVFN---KLMARDGISDKSKKQ 1115 >gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] Length = 1522 Score = 46.6 bits (109), Expect = 8e-05 Identities = 49/203 (24%), Positives = 78/203 (38%), Gaps = 34/203 (16%) Query: 211 CATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELG 270 C L T + R+ ER II + C SI+S I L+G + NK+ Sbjct: 889 CLALITLAVVYAALWRYIRSERSIILINFCLSIISSNILI--LVGQTQTHNKS------- 939 Query: 271 DTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITW--FLAAGRKWSCEAIEQKAVWFH 328 CT L+FF +A W +LT W ++A K I ++ F Sbjct: 940 ----------ICTTTTAFLHFFFLASFCW--VLTEAWQSYMAVTGKIRTRLIRKR---FL 984 Query: 329 AVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLA 388 + WG P + + + +G C++ L Y + P V V ++ Sbjct: 985 CLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLE--GGLLYAFVGPAAAVVLVN---MVI 1039 Query: 389 GIISLNHVRQVIQHDGRNQEKLK 411 GI+ N +++ DG +KLK Sbjct: 1040 GILVFN---KLVSRDGILDKKLK 1059 >gi|163792198 latrophilin 3 precursor [Homo sapiens] Length = 1469 Score = 43.1 bits (100), Expect = 9e-04 Identities = 53/250 (21%), Positives = 100/250 (40%), Gaps = 45/250 (18%) Query: 205 VSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYS--IVSLMYFIGFLLGDSTACNK 262 +S+ CL +FTF F R +R I+ ++C S + L++ IG N+ Sbjct: 887 LSLVCLLICIFTFCFF-----RGLQSDRNTIHKNLCISLFVAELLFLIGI--------NR 933 Query: 263 ADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQ 322 D+ + AC V LL+FF +A W + + ++ + E + Sbjct: 934 TDQPI-------------ACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRR 980 Query: 323 KAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFV---LLPLCLCV 379 K +F+ V +G P + + A++ VC++ L YF+ + P L + Sbjct: 981 K--YFYLVGYGMPALIVAVSAAVD-YRSYGTDKVCWLRL-----DTYFIWSFIGPATLII 1032 Query: 380 FVGLSLLLAGIISLNHVRQVIQH-----DGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGC 434 + + L + + H +++ D N E + F I+ V + L+ L+ L Sbjct: 1033 MLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPF-IKSWVIGAIALLCLLGLTWA 1091 Query: 435 YVYEQVNRIT 444 + +N T Sbjct: 1092 FGLMYINEST 1101 >gi|45433552 G protein-coupled receptor 133 [Homo sapiens] Length = 874 Score = 42.4 bits (98), Expect = 0.001 Identities = 42/192 (21%), Positives = 88/192 (45%), Gaps = 31/192 (16%) Query: 200 SFIG-TVSIFCLCATLFTF--LTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGD 256 S++G ++S+ CL ATL TF L+ + +R RY + ++V + V L+ I F Sbjct: 570 SYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLL--ISF---- 623 Query: 257 STACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWS 316 +LE G T C V+ +LL++F ++ W ++ + + + + Sbjct: 624 ---------RLEPGTT--------PCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFG 666 Query: 317 CEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLC 376 E + K +++ + WG P + ++ L+ ++ S C++ L + + + P Sbjct: 667 SE--DSKHRYYYGMGWGFPLLICIISLSF-AMDSYGTSNNCWLSL--ASGAIWAFVAPAL 721 Query: 377 LCVFVGLSLLLA 388 + V + +L+A Sbjct: 722 FVIVVNIGILIA 733 >gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens] Length = 870 Score = 41.6 bits (96), Expect = 0.003 Identities = 52/225 (23%), Positives = 90/225 (40%), Gaps = 39/225 (17%) Query: 207 IFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEK 266 I + A L TF T +D + Y + + + S++SL++ + LL K + Sbjct: 357 IMYVSAWLLTFPT--MDPKPLAYAIQNVSFDISIVSLISLIWSLAILL----LSKKYKQL 410 Query: 267 LELGDTVVLGSQNKACT-----------------VLFMLLYFFTMAGTVWWVILTITWFL 309 + T +L +Q+ C ++F+LLY + +W +L I+ FL Sbjct: 411 PHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFL 470 Query: 310 AAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRY 369 R E ++ WG P L +LL K GD+I F G + Sbjct: 471 LKKR----ERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQM----- 521 Query: 370 FVLLPLCLCVFVGLSLLLAGI--ISLNHVRQVIQHDGRNQEKLKK 412 + V + S+L+AGI + +N Q ++G +Q + K Sbjct: 522 -----ITTAVTLFCSILIAGISLMCMNQTAQAGSYEGFDQSQSHK 561 >gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo sapiens] Length = 870 Score = 41.6 bits (96), Expect = 0.003 Identities = 52/225 (23%), Positives = 90/225 (40%), Gaps = 39/225 (17%) Query: 207 IFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEK 266 I + A L TF T +D + Y + + + S++SL++ + LL K + Sbjct: 357 IMYVSAWLLTFPT--MDPKPLAYAIQNVSFDISIVSLISLIWSLAILL----LSKKYKQL 410 Query: 267 LELGDTVVLGSQNKACT-----------------VLFMLLYFFTMAGTVWWVILTITWFL 309 + T +L +Q+ C ++F+LLY + +W +L I+ FL Sbjct: 411 PHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFL 470 Query: 310 AAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRY 369 R E ++ WG P L +LL K GD+I F G + Sbjct: 471 LKKR----ERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQM----- 521 Query: 370 FVLLPLCLCVFVGLSLLLAGI--ISLNHVRQVIQHDGRNQEKLKK 412 + V + S+L+AGI + +N Q ++G +Q + K Sbjct: 522 -----ITTAVTLFCSILIAGISLMCMNQTAQAGSYEGFDQSQSHK 561 >gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo sapiens] Length = 1751 Score = 37.0 bits (84), Expect = 0.063 Identities = 30/134 (22%), Positives = 48/134 (35%), Gaps = 14/134 (10%) Query: 26 PITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTC 85 P ++P C + + + PN + H + L C P + F C VP C Sbjct: 338 PPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPC 397 Query: 86 -IEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFL 144 PPC + CE + C W L RL ++P D + + Sbjct: 398 GSVPPPAPPPCCQFCEALQDAC----------W-SRLGGGRLPVACASLPTQEDGYCVLI 446 Query: 145 GPQKKTEQVQRDIG 158 GP E++ ++G Sbjct: 447 GP--AAERISEEVG 458 >gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens] Length = 278 Score = 35.4 bits (80), Expect = 0.18 Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 26/184 (14%) Query: 525 ESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQ- 583 ES E L ++ K ++ PS +L+ + +S TS G T +G S++ + + + G Sbjct: 55 ESAEGMLHAEAQSKIRQS---PSPLRLQ-LDRSQATSPGQT--NGDSSLEVLATRFQGSV 108 Query: 584 ETLTEIQTSPETSMREVKADGASTPRLREQDCGEPASPAASISRLSGEQVDGKG-QAGSV 642 T TE Q+S +S S+P G P SP S S L+GE + Q+ + Sbjct: 109 RTYTESQSSLRSSY--------SSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLAC 160 Query: 643 SESARSEGRIS----PKSDITDTGLAQSNNLQV------PSSSEPSSLKGSTSLLVHPVS 692 S + R+S P S G A + + V P SS PS SLL+ S Sbjct: 161 SPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDS 220 Query: 693 GVRK 696 V K Sbjct: 221 EVFK 224 >gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens] Length = 366 Score = 35.4 bits (80), Expect = 0.18 Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 26/184 (14%) Query: 525 ESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQ- 583 ES E L ++ K ++ PS +L+ + +S TS G T +G S++ + + + G Sbjct: 55 ESAEGMLHAEAQSKIRQS---PSPLRLQ-LDRSQATSPGQT--NGDSSLEVLATRFQGSV 108 Query: 584 ETLTEIQTSPETSMREVKADGASTPRLREQDCGEPASPAASISRLSGEQVDGKG-QAGSV 642 T TE Q+S +S S+P G P SP S S L+GE + Q+ + Sbjct: 109 RTYTESQSSLRSSY--------SSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLAC 160 Query: 643 SESARSEGRIS----PKSDITDTGLAQSNNLQV------PSSSEPSSLKGSTSLLVHPVS 692 S + R+S P S G A + + V P SS PS SLL+ S Sbjct: 161 SPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDS 220 Query: 693 GVRK 696 V K Sbjct: 221 EVFK 224 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.324 0.137 0.435 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,732,950 Number of Sequences: 37866 Number of extensions: 1268681 Number of successful extensions: 5079 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 23 Number of HSP's successfully gapped in prelim test: 60 Number of HSP's that attempted gapping in prelim test: 4945 Number of HSP's gapped (non-prelim): 150 length of query: 706 length of database: 18,247,518 effective HSP length: 109 effective length of query: 597 effective length of database: 14,120,124 effective search space: 8429714028 effective search space used: 8429714028 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.5 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.