Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 33620742
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
(493 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33620742 Fzr1 protein isoform 2 [Homo sapiens] 999 0.0
gi|209969680 Fzr1 protein isoform 1 [Homo sapiens] 994 0.0
gi|209969678 Fzr1 protein isoform 3 [Homo sapiens] 564 e-161
gi|118402582 cell division cycle 20 [Homo sapiens] 325 6e-89
gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Ho... 208 8e-54
gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [H... 174 2e-43
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 86 6e-17
gi|113865883 WD repeat domain 38 [Homo sapiens] 84 3e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens] 79 1e-14
gi|32189425 WD repeat domain 69 [Homo sapiens] 77 4e-14
gi|16554629 WD repeat domain 5 [Homo sapiens] 76 6e-14
gi|16554627 WD repeat domain 5 [Homo sapiens] 76 6e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 76 6e-14
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 75 2e-13
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 74 2e-13
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 74 3e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 73 5e-13
gi|23199987 WD repeat domain 5B [Homo sapiens] 73 5e-13
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 72 1e-12
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 72 1e-12
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 72 1e-12
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 72 1e-12
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 72 2e-12
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 71 2e-12
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 71 2e-12
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 71 2e-12
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 71 2e-12
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 71 2e-12
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 71 3e-12
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 69 7e-12
>gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
Length = 493
Score = 999 bits (2584), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 1 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 60
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN
Sbjct: 1 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 60
Query: 61 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 120
FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS
Sbjct: 61 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 120
Query: 121 TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD 180
TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD
Sbjct: 121 TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD 180
Query: 181 APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER 240
APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER
Sbjct: 181 APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER 240
Query: 241 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT 300
GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT
Sbjct: 241 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT 300
Query: 301 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 360
PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA
Sbjct: 301 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 360
Query: 361 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 420
IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY
Sbjct: 361 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 420
Query: 421 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 480
SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK
Sbjct: 421 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 480
Query: 481 ESVSVLNLFTRIR 493
ESVSVLNLFTRIR
Sbjct: 481 ESVSVLNLFTRIR 493
>gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]
Length = 496
Score = 994 bits (2570), Expect = 0.0
Identities = 493/496 (99%), Positives = 493/496 (99%), Gaps = 3/496 (0%)
Query: 1 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 60
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN
Sbjct: 1 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 60
Query: 61 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 120
FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS
Sbjct: 61 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 120
Query: 121 TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD 180
TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD
Sbjct: 121 TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD 180
Query: 181 APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER 240
APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER
Sbjct: 181 APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER 240
Query: 241 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT 300
GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT
Sbjct: 241 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT 300
Query: 301 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 360
PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA
Sbjct: 301 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 360
Query: 361 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 420
IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY
Sbjct: 361 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 420
Query: 421 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 480
SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK
Sbjct: 421 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 480
Query: 481 ---ESVSVLNLFTRIR 493
ESVSVLNLFTRIR
Sbjct: 481 VKWESVSVLNLFTRIR 496
>gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
Length = 404
Score = 564 bits (1454), Expect = e-161
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 219 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 278
VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA
Sbjct: 130 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 189
Query: 279 WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 338
WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL
Sbjct: 190 WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 249
Query: 339 VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 398
VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT
Sbjct: 250 VWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 309
Query: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 458
GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI
Sbjct: 310 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 369
Query: 459 VTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 493
VTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR
Sbjct: 370 VTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 404
Score = 299 bits (765), Expect = 4e-81
Identities = 189/401 (47%), Positives = 226/401 (56%), Gaps = 28/401 (6%)
Query: 1 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 60
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN
Sbjct: 1 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 60
Query: 61 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 120
FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS
Sbjct: 61 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 120
Query: 121 TPEKKGLFTYS----LSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPF 176
TPEKKGLFT + LS + S +L V + +K+S +
Sbjct: 121 TPEKKGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEG 180
Query: 177 KVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVG 236
L W++ + S + T + L V +
Sbjct: 181 HTARVGALA---------WNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLK 231
Query: 237 WSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ-----LSSGSRDR 291
WS L+A G + + +W+ ++ + H A V A+AW+ Q G+ DR
Sbjct: 232 WSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADR 291
Query: 292 MI-LQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLAS--GGNDNKLLVWNHSSLSPV 348
I + PLQ +VC L WS L S G + N++LVW + SL+ V
Sbjct: 292 CIRFWNTLTGQPLQ----CIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQV 347
Query: 349 QQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT 389
+ T H V +A SP ++ G D +RFWN +
Sbjct: 348 AKLTGHSYRVLYLAMSPDGEAIVT---GAGDETLRFWNVFS 385
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 325 bits (833), Expect = 6e-89
Identities = 187/457 (40%), Positives = 261/457 (57%), Gaps = 53/457 (11%)
Query: 29 RTLTPASSPV-SSPSKHG-DRFIPSRAGANWSV-NFHRINENEKSPSQNRKAKD-----A 80
RT +SS V ++PSK G DR+IP R+ A V +F EN+ SQ K+ A
Sbjct: 58 RTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWA 117
Query: 81 TSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPD 140
+ NG D + + ++L + P+ RL+ L +++++P
Sbjct: 118 LNLNGFD------VEEAKILRLSGKPQNAPEGYQNRLKV------------LYSQKATPG 159
Query: 141 DGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNV 200
S RK R I +P ++LDAPE+++D+YLNLVDWSS NV
Sbjct: 160 ----------------------SSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNV 197
Query: 201 LSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAA 260
L+V L VYLWSA + + +L + G+ ++SV W + GN +AVGT VQ+WD
Sbjct: 198 LAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ 257
Query: 261 GKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLK 320
K+L + H+ARVG+L+WN+ LSSGSR I D+R L GH QEVCGL+
Sbjct: 258 QKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLR 316
Query: 321 WSTDHQLLASGGNDNKLLVW----NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGG 376
W+ D + LASGGNDN + VW P+Q +T+H AVKA+AW P Q +LA+GGG
Sbjct: 317 WAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376
Query: 377 TADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQV 436
T+DR IR WN +G L +D SQVC++ WS H EL+S HG++QNQ+++WKYP++ +V
Sbjct: 377 TSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436
Query: 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473
A+L GH+ RVL L MSPDG + + A DETLR W F
Sbjct: 437 AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/128 (25%), Positives = 65/128 (50%), Gaps = 12/128 (9%)
Query: 231 SVTSVGWSE-RGNLVAVG--THKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLS 285
+V +V W + N++A G T ++IW+ +G LS ++ H+ +V ++ W+ ++L
Sbjct: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELI 415
Query: 286 SG---SRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 342
SG +++++++ + P + L+GH V L S D +AS D L +W
Sbjct: 416 SGHGFAQNQLVIWK---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
Query: 343 SSLSPVQQ 350
L P ++
Sbjct: 473 FELDPARR 480
>gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Homo
sapiens]
Length = 515
Score = 208 bits (530), Expect = 8e-54
Identities = 110/294 (37%), Positives = 165/294 (56%), Gaps = 10/294 (3%)
Query: 184 LQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNL 243
L++D+YLN++DWS N++++ LG+ VY+W+ DLS+ + ++SV W + G
Sbjct: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287
Query: 244 VAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPL 303
+AVGT +G VQ+WD K+L + GH + VGAL+WN LSSGSR + D+R
Sbjct: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRV--A 345
Query: 304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ----QYTEHLAAVK 359
Q H+Q VC LKWS D +LL+SG +D L +W H + Q + AVK
Sbjct: 346 QHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVK 405
Query: 360 AIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHG 419
A+ W P Q G+LA GGG D + + G+ +Q T SQ+C+L W E+ + G
Sbjct: 406 AMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQG 465
Query: 420 YSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473
+N + VW P++++ +GH RVL+LA+SPD + + A D T WN +
Sbjct: 466 TPKNDVTVWTCPTVSR----SGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 515
>gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [Homo
sapiens]
Length = 477
Score = 174 bits (441), Expect = 2e-43
Identities = 99/292 (33%), Positives = 147/292 (50%), Gaps = 44/292 (15%)
Query: 184 LQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNL 243
L++D+YLN++DWS N++++ LG+ VY+W+ DLS+ + ++SV W + G
Sbjct: 228 LRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTC 287
Query: 244 VAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPL 303
+AVGT +G VQ+WD K+L + GH + VGAL+WN LSSGSR + D+R
Sbjct: 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRV--A 345
Query: 304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAW 363
Q H+Q VC LKWS D +LL+SG +D L +W
Sbjct: 346 QHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIW----------------------- 382
Query: 364 SPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DTGSQVCNLAWSKHANELVSTHGYS 421
PH G A GQPL+ I T ++C+L W E+ + G
Sbjct: 383 -PHDPGASAQ----------------GQPLKVITQSTAVKICSLIWLPKTKEIATGQGTP 425
Query: 422 QNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473
+N + VW P++++ GH RVL+LA+SPD + + A D T WN +
Sbjct: 426 KNDVTVWTCPTVSRSGGFFGHRGRVLHLALSPDQTRVFSAAADGTASVWNCY 477
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 86.3 bits (212), Expect = 6e-17
Identities = 86/313 (27%), Positives = 128/313 (40%), Gaps = 60/313 (19%)
Query: 209 VYLWSACTS-QVTRLCDLSVEGDSVTSVGW-----SERGNLVAVGTHKGFVQIWDAAAGK 262
+ LW T QV R L+ +T + W + VA + G V+IWD AG+
Sbjct: 180 ILLWDPSTGKQVGRT--LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGR 237
Query: 263 KLSMLEGHTARVGALAWNAEQLS-SGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKW 321
+L GHT V L W + L S S+DR I L R LQGH V +
Sbjct: 238 CERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLC--RTLQGHGHWVNTMAL 295
Query: 322 STDHQL------------------------------------------LASGGNDNKLLV 339
STD+ L L SG +D L +
Sbjct: 296 STDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFL 355
Query: 340 WNHSS-LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 398
W+ + P+ + T H A + + +SP ++AS + D+ I+ W+ TG+ L +
Sbjct: 356 WSPAEDKKPLTRMTGHQALINQVLFSPDSR-IVASA--SFDKSIKLWDGRTGKYLASLRG 412
Query: 399 G-SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEA 457
+ V +AWS + LVS G S + + VW + L GH+ V + SPDG+
Sbjct: 413 HVAAVYQIAWSADSRLLVS--GSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQR 470
Query: 458 IVTGAGDETLRFW 470
+ +G D+ LR W
Sbjct: 471 VASGGKDKCLRIW 483
Score = 77.4 bits (189), Expect = 3e-14
Identities = 85/330 (25%), Positives = 128/330 (38%), Gaps = 60/330 (18%)
Query: 200 VLSVGLG-TCVYLWSACTSQVTRLCDLSVEGDSVT---------SVGWSERGNLVAVGTH 249
V+SV T YL S R DLS E T S+ WS G +A G
Sbjct: 117 VISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCK 176
Query: 250 KGFVQIWDAAAGKKLS-MLEGHTARVGALAW-------NAEQLSSGSRDRMILQRDIRTP 301
G + +WD + GK++ L GH+ + L+W ++S S+D + D T
Sbjct: 177 NGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD--TT 234
Query: 302 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH----------------SSL 345
+ ER L GH Q V L+W D LL S D + VW +++
Sbjct: 235 AGRCERILTGHTQSVTCLRWGGD-GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTM 293
Query: 346 SPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNL 405
+ Y A + S + L S +R + +N + GQ + + +GS L
Sbjct: 294 ALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTL 353
Query: 406 -AWS----KHANELVSTHGYSQNQIL------------------VWKYPSLTQVAKLTGH 442
WS K ++ H NQ+L +W + +A L GH
Sbjct: 354 FLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGH 413
Query: 443 SYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
V +A S D +V+G+ D TL+ W+V
Sbjct: 414 VAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Score = 66.2 bits (160), Expect = 6e-11
Identities = 70/263 (26%), Positives = 114/263 (43%), Gaps = 18/263 (6%)
Query: 219 VTRLCDLSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGA 276
VTR C S+EG S V SV +S G +A G+ V+ WD + +GH V +
Sbjct: 103 VTR-CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161
Query: 277 LAWNAE--QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH-----QLLA 329
++W+ + +L+SG ++ IL D T Q R L GH + + GL W H + +A
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHANPECRYVA 220
Query: 330 SGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT 389
S D + +W+ ++ + T H +V + W GLL S + DR I+ W
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWG--GDGLLYS--ASQDRTIKVWRAHD 276
Query: 390 GQPLQCID-TGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLY 448
G + + G V +A S + + T + + V + +L +
Sbjct: 277 GVLCRTLQGHGHWVNTMALS--TDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYN 334
Query: 449 LAMSPDGEAIVTGAGDETLRFWN 471
L E +V+G+ D TL W+
Sbjct: 335 LVRGQGPERLVSGSDDFTLFLWS 357
Score = 42.7 bits (99), Expect = 7e-04
Identities = 17/40 (42%), Positives = 29/40 (72%)
Query: 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKT 476
+ L GHS V+ +A SP G+ + +G+GD T+RFW++ ++T
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTET 147
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 84.0 bits (206), Expect = 3e-16
Identities = 79/267 (29%), Positives = 126/267 (47%), Gaps = 16/267 (5%)
Query: 208 CVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSML 267
CVY W + Q+ L L V +S G+L A + V++WD A K L +L
Sbjct: 44 CVYGWETRSGQL--LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL 101
Query: 268 EGHTARVGALAWNAE--QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH 325
+GH V ++++ + QL+SG D+ ++ D+++ Q R L GHR + +S
Sbjct: 102 KGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG--QMLRLLVGHRDSIQSSDFSPTV 159
Query: 326 QLLASGGNDNKLLVWNHSSLSPV---QQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCI 382
LA+G D+ + +W+ ++P Q H A + + +S GLLASG D+ I
Sbjct: 160 NCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSAS--GLLASGSW--DKTI 215
Query: 383 RFWNTLTGQPL-QCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTG 441
W T L Q + V ++A+S L S GYS+ + VW + + L G
Sbjct: 216 HIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASA-GYSR-MVKVWDCNTGKCLETLKG 273
Query: 442 HSYRVLYLAMSPDGEAIVTGAGDETLR 468
A +PDG+ +V+GA D+T R
Sbjct: 274 VLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 70.1 bits (170), Expect = 4e-12
Identities = 62/261 (23%), Positives = 117/261 (44%), Gaps = 12/261 (4%)
Query: 216 TSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVG 275
T V R+ G V S +S G ++ G+ G V W+ +G+ L L GHT V
Sbjct: 8 TLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVK 67
Query: 276 ALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGN 333
++ + +S S D + D+ + R L+GH++ V + +S D + LASGG
Sbjct: 68 FCRFSPDGHLFASASCDCTVRLWDVARA--KCLRVLKGHQRSVETVSFSPDSRQLASGGW 125
Query: 334 DNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPL 393
D ++++W+ S ++ H ++++ +SP + L G+ D + W+ P
Sbjct: 126 DKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT---GSWDSTVHIWDLRMVTPA 182
Query: 394 ---QCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA 450
Q ++ S N++ ++ + G I +WK + + + +L GH V +A
Sbjct: 183 VSHQALEGHS--ANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIA 240
Query: 451 MSPDGEAIVTGAGDETLRFWN 471
SPD + + ++ W+
Sbjct: 241 FSPDELWLASAGYSRMVKVWD 261
Score = 52.0 bits (123), Expect = 1e-06
Identities = 41/162 (25%), Positives = 71/162 (43%), Gaps = 6/162 (3%)
Query: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 371
H EV +S D Q+L +G D + W S + + H VK +SP H L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH-LF 78
Query: 372 ASGGGTADRCIRFWNTLTGQPLQCIDTGSQ-VCNLAWSKHANELVSTHGYSQNQILVWKY 430
AS + D +R W+ + L+ + + V +++S + +L S G ++++W
Sbjct: 79 ASA--SCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS--GGWDKRVMLWDV 134
Query: 431 PSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
S + L GH + SP + TG+ D T+ W++
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 40.0 bits (92), Expect = 0.005
Identities = 34/130 (26%), Positives = 55/130 (42%), Gaps = 10/130 (7%)
Query: 348 VQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCID--TGS-QVCN 404
V+ + +H V + A+SP LL G+ D C+ W T +GQ L + TG + C
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLT---GSEDGCVYGWETRSGQLLWRLGGHTGPVKFCR 70
Query: 405 LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGD 464
+ H S + +W + L GH V ++ SPD + +G D
Sbjct: 71 FSPDGHLFASASC----DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWD 126
Query: 465 ETLRFWNVFS 474
+ + W+V S
Sbjct: 127 KRVMLWDVQS 136
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 78.6 bits (192), Expect = 1e-14
Identities = 59/222 (26%), Positives = 105/222 (47%), Gaps = 12/222 (5%)
Query: 254 QIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQG 311
+I D +L +L GH+ V +++ ++ L S S D + ++T +G
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT--FTCLVGYKG 583
Query: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 371
H V ++S SGG+D +W P++ + HLA V + P+ + +
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 372 ASGGGTADRCIRFWNTLTGQPLQCIDTGSQ--VCNLAWSKHANELVSTHGYSQNQILVWK 429
G+ADR +R W+ L G ++ I TG + + +L +S + L + G + ++L+W
Sbjct: 644 T---GSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFLAT--GATDGRVLLWD 697
Query: 430 YPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
V +L GH+ V L S DGE + +G+ D T+R W+
Sbjct: 698 IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 63.9 bits (154), Expect = 3e-10
Identities = 58/241 (24%), Positives = 97/241 (40%), Gaps = 15/241 (6%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDR 291
+T+V ++ +L+A G V++W K S+ + A + + S D
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQ---------ASDLSLIDKESDD- 522
Query: 292 MILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY 351
+L+R + + L GH V G +S D L S D + +W+ + + + Y
Sbjct: 523 -VLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 352 TEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHA 411
H V +SP+ + ++ G DR R W T QPL+ I G H
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGH---DRVARLWATDHYQPLR-IFAGHLADVNCTRFHP 637
Query: 412 NELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
N G + + +W + V TGH + L SP+G + TGA D + W+
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Query: 472 V 472
+
Sbjct: 698 I 698
Score = 39.7 bits (91), Expect = 0.006
Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 4/87 (4%)
Query: 209 VYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLE 268
V LW R+ + + S+ +S G +A G G V +WD G + L+
Sbjct: 651 VRLWDVLNGNCVRI--FTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK 708
Query: 269 GHTARVGALAW--NAEQLSSGSRDRMI 293
GHT V +L + + E L+SGS D +
Sbjct: 709 GHTDTVCSLRFSRDGEILASGSMDNTV 735
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 77.0 bits (188), Expect = 4e-14
Identities = 50/233 (21%), Positives = 107/233 (45%), Gaps = 8/233 (3%)
Query: 241 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDI 298
G+ +A G+ ++W GK GHTA + L++N + +++GS D DI
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 299 RTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAV 358
+ + L+GH E+ L ++T + +G D+ ++VW+ + V H A +
Sbjct: 207 QNG--EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
Query: 359 KAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTH 418
+ +++ +L G+ D+ + W+ G+ + + + + +L++T
Sbjct: 265 SSASFNWDCSLILT---GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
Query: 419 GYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
+ ++ + +AKL GH + ++ +P G ++TG+ D+T R W+
Sbjct: 322 S-ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 68.6 bits (166), Expect = 1e-11
Identities = 58/265 (21%), Positives = 122/265 (46%), Gaps = 16/265 (6%)
Query: 211 LWSACTSQVTRLCDLSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLE 268
LWS T + C + G + + + ++ + LVA G+ ++WD G+++ L
Sbjct: 161 LWSVETGK----CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 269 GHTARVGALAWNA--EQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQ 326
GH+A + +L++N +++ +GS D ++ D T + L GH E+ ++ D
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG--RKVNILIGHCAEISSASFNWDCS 274
Query: 327 LLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWN 386
L+ +G D +W+ ++ V T H + + + L+A+ +AD R ++
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD-YTGKLIATA--SADGTARIFS 331
Query: 387 TLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYR 445
T + + ++ ++ ++++ N L++ G S +W + + L GH+
Sbjct: 332 AATRKCIAKLEGHEGEISKISFNPQGNHLLT--GSSDKTARIWDAQTGQCLQVLEGHTDE 389
Query: 446 VLYLAMSPDGEAIVTGAGDETLRFW 470
+ A + G ++TG+ D T R W
Sbjct: 390 IFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 53.5 bits (127), Expect = 4e-07
Identities = 35/149 (23%), Positives = 67/149 (44%), Gaps = 6/149 (4%)
Query: 194 DWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFV 253
+W +L+ + LW A + + L+ D + + G L+A + G
Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGKC--VATLTGHDDEILDSCFDYTGKLIATASADGTA 327
Query: 254 QIWDAAAGKKLSMLEGHTARVGALAWNAE--QLSSGSRDRMILQRDIRTPPLQSERRLQG 311
+I+ AA K ++ LEGH + +++N + L +GS D+ D +T Q + L+G
Sbjct: 328 RIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTG--QCLQVLEG 385
Query: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVW 340
H E+ ++ ++ +G DN +W
Sbjct: 386 HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 76.3 bits (186), Expect = 6e-14
Identities = 62/249 (24%), Positives = 112/249 (44%), Gaps = 18/249 (7%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 289
++ V WS NL+ + ++IWD ++GK L L+GH+ V +N + + SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349
D + D++T + + L H V + ++ D L+ S D +W+ +S ++
Sbjct: 150 DESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 350 Q-YTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 408
+ V + +SP+ +LA+ T D ++ W+ G +C+ T + N +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAA---TLDNTLKLWDYSKG---KCLKTYTGHKNEKYC 261
Query: 409 KHANELVS-----THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA- 462
AN V+ G N + +W + V KL GH+ V+ A P I + A
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
Query: 463 -GDETLRFW 470
D+T++ W
Sbjct: 322 ENDKTIKLW 330
Score = 69.7 bits (169), Expect = 6e-12
Identities = 63/269 (23%), Positives = 119/269 (44%), Gaps = 19/269 (7%)
Query: 231 SVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGS 288
+V+SV +S G +A + ++IW A GK + GH + +AW+++ L S S
Sbjct: 47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS 106
Query: 289 RDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348
D+ + D+ + + + L+GH V ++ L+ SG D + +W+ + +
Sbjct: 107 DDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164
Query: 349 QQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DTGSQVCNLA 406
+ H V A+ ++ +++S + D R W+T +GQ L+ + D V +
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 407 WSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH---SYRVLYLAMSPDGEAIVTGAG 463
+S + +++ N + +W Y + TGH Y + G+ IV+G+
Sbjct: 222 FSPNGKYILA--ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279
Query: 464 DETLRFWNVFSKTRSTKESVSVLNLFTRI 492
D + WN+ TKE V L T +
Sbjct: 280 DNLVYIWNL-----QTKEIVQKLQGHTDV 303
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/218 (26%), Positives = 101/218 (46%), Gaps = 12/218 (5%)
Query: 267 LEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTD 324
L GHT V ++ + N E L+S S D++I + + E+ + GH+ + + WS+D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLI--KIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 325 HQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRF 384
LL S +D L +W+ SS ++ H V ++P Q L+ S G+ D +R
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVS--GSFDESVRI 155
Query: 385 WNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAK--LTGH 442
W+ TG+ L+ + S + L+ + Y +W S Q K +
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY-DGLCRIWDTAS-GQCLKTLIDDD 213
Query: 443 SYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 480
+ V ++ SP+G+ I+ D TL+ W+ +SK + K
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWD-YSKGKCLK 250
Score = 52.8 bits (125), Expect = 7e-07
Identities = 45/200 (22%), Positives = 88/200 (44%), Gaps = 23/200 (11%)
Query: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAA 259
++S V +W T + + L D V++V ++ G+L+ ++ G +IWD A
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLKT--LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 260 AGKKL-SMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE- 315
+G+ L ++++ V + + N + + + + D + D + + GH+ E
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG--KCLKTYTGHKNEK 259
Query: 316 --------VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367
V G KW + SG DN + +WN + VQ+ H V + A P +
Sbjct: 260 YCIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE 313
Query: 368 HGLLASGGGTADRCIRFWNT 387
+ ++AS D+ I+ W +
Sbjct: 314 N-IIASAALENDKTIKLWKS 332
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 76.3 bits (186), Expect = 6e-14
Identities = 62/249 (24%), Positives = 112/249 (44%), Gaps = 18/249 (7%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 289
++ V WS NL+ + ++IWD ++GK L L+GH+ V +N + + SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349
D + D++T + + L H V + ++ D L+ S D +W+ +S ++
Sbjct: 150 DESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 350 Q-YTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 408
+ V + +SP+ +LA+ T D ++ W+ G +C+ T + N +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAA---TLDNTLKLWDYSKG---KCLKTYTGHKNEKYC 261
Query: 409 KHANELVS-----THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA- 462
AN V+ G N + +W + V KL GH+ V+ A P I + A
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
Query: 463 -GDETLRFW 470
D+T++ W
Sbjct: 322 ENDKTIKLW 330
Score = 69.7 bits (169), Expect = 6e-12
Identities = 63/269 (23%), Positives = 119/269 (44%), Gaps = 19/269 (7%)
Query: 231 SVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGS 288
+V+SV +S G +A + ++IW A GK + GH + +AW+++ L S S
Sbjct: 47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS 106
Query: 289 RDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348
D+ + D+ + + + L+GH V ++ L+ SG D + +W+ + +
Sbjct: 107 DDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164
Query: 349 QQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DTGSQVCNLA 406
+ H V A+ ++ +++S + D R W+T +GQ L+ + D V +
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 407 WSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH---SYRVLYLAMSPDGEAIVTGAG 463
+S + +++ N + +W Y + TGH Y + G+ IV+G+
Sbjct: 222 FSPNGKYILA--ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279
Query: 464 DETLRFWNVFSKTRSTKESVSVLNLFTRI 492
D + WN+ TKE V L T +
Sbjct: 280 DNLVYIWNL-----QTKEIVQKLQGHTDV 303
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/218 (26%), Positives = 101/218 (46%), Gaps = 12/218 (5%)
Query: 267 LEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTD 324
L GHT V ++ + N E L+S S D++I + + E+ + GH+ + + WS+D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLI--KIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 325 HQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRF 384
LL S +D L +W+ SS ++ H V ++P Q L+ S G+ D +R
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVS--GSFDESVRI 155
Query: 385 WNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAK--LTGH 442
W+ TG+ L+ + S + L+ + Y +W S Q K +
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY-DGLCRIWDTAS-GQCLKTLIDDD 213
Query: 443 SYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 480
+ V ++ SP+G+ I+ D TL+ W+ +SK + K
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWD-YSKGKCLK 250
Score = 52.8 bits (125), Expect = 7e-07
Identities = 45/200 (22%), Positives = 88/200 (44%), Gaps = 23/200 (11%)
Query: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAA 259
++S V +W T + + L D V++V ++ G+L+ ++ G +IWD A
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLKT--LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 260 AGKKL-SMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE- 315
+G+ L ++++ V + + N + + + + D + D + + GH+ E
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG--KCLKTYTGHKNEK 259
Query: 316 --------VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367
V G KW + SG DN + +WN + VQ+ H V + A P +
Sbjct: 260 YCIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE 313
Query: 368 HGLLASGGGTADRCIRFWNT 387
+ ++AS D+ I+ W +
Sbjct: 314 N-IIASAALENDKTIKLWKS 332
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 76.3 bits (186), Expect = 6e-14
Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 12/220 (5%)
Query: 257 DAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQGHRQ 314
D AG ++ +L GH V + + A+ L S S D I D+ + + QGH
Sbjct: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS--FTNTVLYQGHAY 385
Query: 315 EVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASG 374
V L S ASG +D +W+ P++ Y HLA V + + P+ + L
Sbjct: 386 PVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLAT-- 443
Query: 375 GGTADRCIRFWNTLTGQPLQCIDTGSQ--VCNLAWSKHANELVSTHGYSQNQILVWKYPS 432
G+ D+ +R W+ G ++ TG + V +LA+S + L S ++ +W S
Sbjct: 444 -GSTDKTVRLWSAQQGNSVRLF-TGHRGPVLSLAFSPNGKYLASAG--EDQRLKLWDLAS 499
Query: 433 LTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
T +L GH+ + L SPD I + + D ++R W++
Sbjct: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 57.0 bits (136), Expect = 4e-08
Identities = 47/184 (25%), Positives = 82/184 (44%), Gaps = 18/184 (9%)
Query: 245 AVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPP 302
A G+H ++W L + GH A V + + N+ L++GS D+ + R
Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV--RLWSAQQ 457
Query: 303 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 362
S R GHR V L +S + + LAS G D +L +W+ +S + ++ H + ++
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517
Query: 363 WSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQ 422
+SP GL+AS + D +R W D + C+ ++ELV +
Sbjct: 518 FSP-DSGLIAS--ASMDNSVRVW-----------DIRNTYCSAPADGSSSELVGVYTGQM 563
Query: 423 NQIL 426
+ +L
Sbjct: 564 SNVL 567
Score = 56.6 bits (135), Expect = 5e-08
Identities = 45/168 (26%), Positives = 67/168 (39%), Gaps = 4/168 (2%)
Query: 309 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQH 368
L+GH V ++ D L S D + W+ S + Y H V + SP+
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS- 396
Query: 369 GLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVW 428
L G+ DR R W+ PL+ I G H N G + + +W
Sbjct: 397 --LYFASGSHDRTARLWSFDRTYPLR-IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW 453
Query: 429 KYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKT 476
V TGH VL LA SP+G+ + + D+ L+ W++ S T
Sbjct: 454 SAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT 501
Score = 55.8 bits (133), Expect = 9e-08
Identities = 34/112 (30%), Positives = 55/112 (49%), Gaps = 4/112 (3%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSR 289
V V + N +A G+ V++W A G + + GH V +LA+ N + L+S
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
D+ + D+ + L E L+GH + L +S D L+AS DN + VW+
Sbjct: 489 DQRLKLWDLASGTLYKE--LRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 38.9 bits (89), Expect = 0.011
Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 4/93 (4%)
Query: 209 VYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLE 268
V LWSA RL + V S+ +S G +A +++WD A+G L
Sbjct: 450 VRLWSAQQGNSVRL--FTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELR 507
Query: 269 GHTARVGALAWNAEQ--LSSGSRDRMILQRDIR 299
GHT + +L ++ + ++S S D + DIR
Sbjct: 508 GHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 74.7 bits (182), Expect = 2e-13
Identities = 61/251 (24%), Positives = 109/251 (43%), Gaps = 19/251 (7%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 289
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + + S
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349
D+ + D T +++++ H + W +++ AS D + V P++
Sbjct: 287 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKLGQDRPIK 343
Query: 350 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 408
+ H V AI W P + LLAS D ++ W+ + + ++ + WS
Sbjct: 344 TFQGHTNEVNAIKWDPTGN-LLASCSD--DMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 400
Query: 409 K--------HANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 460
+AN ++++ + + +W + LT H V +A SPDG + +
Sbjct: 401 PTGPGTNNPNANLMLASASFDST-VRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLAS 459
Query: 461 GAGDETLRFWN 471
G+ D+ + WN
Sbjct: 460 GSFDKCVHIWN 470
Score = 49.7 bits (117), Expect = 6e-06
Identities = 47/222 (21%), Positives = 93/222 (41%), Gaps = 17/222 (7%)
Query: 252 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 311
F+ W+ + S TAR+ WN + S+ +++L+ IR + + +
Sbjct: 173 FICAWNPVSDLLASGSGDSTARI----WNLSENSTSGSTQLVLRHCIR----EGGQDVPS 224
Query: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 371
++ +V L W+++ LLA+G D +W + +H + A+ W+ + +L
Sbjct: 225 NK-DVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGNFIL 282
Query: 372 ASGGGTADRCIRFWNTLTGQPLQCIDTGSQ-VCNLAWSKHANELVSTHGYSQNQILVWKY 430
++G D+ W+ TG+ Q S ++ W + N S + I V K
Sbjct: 283 SAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NTFASCS--TDMCIHVCKL 336
Query: 431 PSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
+ GH+ V + P G + + + D TL+ W++
Sbjct: 337 GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSM 378
Score = 34.3 bits (77), Expect = 0.27
Identities = 14/40 (35%), Positives = 21/40 (52%)
Query: 439 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 478
L GH V A +P + + +G+GD T R WN+ + S
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTS 204
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 74.3 bits (181), Expect = 2e-13
Identities = 66/294 (22%), Positives = 118/294 (40%), Gaps = 32/294 (10%)
Query: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAA 259
++S + +W T R L DSV + + G L+A + +++WD
Sbjct: 123 MVSASEDATIKVWDYETGDFERT--LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 260 AGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVC 317
+ + + GH V ++A N + + S SRD+ I +++T + GHR+ V
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTG--YCVKTFTGHREWVR 238
Query: 318 GLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASG--- 374
++ + D L+AS ND + VW ++ + EH V+ I+W+P S
Sbjct: 239 MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATG 298
Query: 375 --------------GGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSK----HANELVS 416
G+ D+ I+ W+ TG L + V + W + H+
Sbjct: 299 SETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL-----VGHDNWVRGVLFHSGGKFI 353
Query: 417 THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470
+ VW Y + + L H + V L +VTG+ D+T++ W
Sbjct: 354 LSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 50.4 bits (119), Expect = 4e-06
Identities = 45/171 (26%), Positives = 77/171 (45%), Gaps = 12/171 (7%)
Query: 309 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQH 368
L GHR V + + ++ S D + VW++ + + H +V+ I++ H
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSG 162
Query: 369 GLLASGGGTADRCIRFWNTLTGQPLQCIDT----GSQVCNLAWSKHANELVSTHGYSQNQ 424
LLAS +AD I+ W+ Q +CI T V ++A + + +VS
Sbjct: 163 KLLASC--SADMTIKLWDF---QGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS--RDKT 215
Query: 425 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 475
I +W+ + V TGH V + + DG I + + D+T+R W V +K
Sbjct: 216 IKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK 266
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 73.9 bits (180), Expect = 3e-13
Identities = 67/269 (24%), Positives = 114/269 (42%), Gaps = 17/269 (6%)
Query: 211 LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGK---KLSM- 266
+W + T+ ++ + + V + ++ GN VA G I++ + ++S
Sbjct: 81 IWDSYTTN--KMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRE 138
Query: 267 LEGHTARVGALAW-NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH 325
L GHT + + + Q+ + S D DI T Q GH +V L S D
Sbjct: 139 LPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETA--QQTTTFTGHSGDVMSLSLSPDM 196
Query: 326 QLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385
+ SG D +W+ Q +T H++ + A+++ P+ + A G+ D R +
Sbjct: 197 RTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGY---AFATGSDDATCRLF 253
Query: 386 NTLTGQPLQCIDTGSQVCNL---AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH 442
+ Q L + +C + A+SK L++ GY VW + L GH
Sbjct: 254 DLRADQELLLYSHDNIICGITSVAFSKSGRLLLA--GYDDFNCNVWDTLKGDRAGVLAGH 311
Query: 443 SYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
RV L ++ DG A+ TG+ D LR WN
Sbjct: 312 DNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 62.0 bits (149), Expect = 1e-09
Identities = 40/171 (23%), Positives = 74/171 (43%), Gaps = 3/171 (1%)
Query: 303 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 362
+++ R L+GH ++ + W D +LL S D KL++W+ + + + + V A
Sbjct: 45 MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCA 104
Query: 363 WSPHQHGLLASGGGTADRC-IRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYS 421
++P G + GG + C I T G + L+ + ++
Sbjct: 105 YAP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG 162
Query: 422 QNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
+W + Q TGHS V+ L++SPD V+GA D + + W++
Sbjct: 163 DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDI 213
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 73.2 bits (178), Expect = 5e-13
Identities = 59/252 (23%), Positives = 105/252 (41%), Gaps = 9/252 (3%)
Query: 216 TSQVTRLCDLSVEGDSVTSVGWSER-GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARV 274
T +L ++ +V+S+ + G L+A G V +W + L GHT+ V
Sbjct: 7 TKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV 66
Query: 275 GALAWNA--EQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGG 332
++ N E + +GS+ I D+ + R L GH+ +C L + + +ASG
Sbjct: 67 ESVRLNTPEELIVAGSQSGSIRVWDLEAAKIL--RTLMGHKANICSLDFHPYGEFVASGS 124
Query: 333 NDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQP 392
D + +W+ V +Y H AV+ + +SP L ++ D ++ W+ G+
Sbjct: 125 QDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD---DHTVKLWDLTAGKM 181
Query: 393 LQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMS 452
+ + N+ H NE + G S I W V+ + G V + +
Sbjct: 182 MSEFPGHTGPVNVV-EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN 240
Query: 453 PDGEAIVTGAGD 464
PDG + +G D
Sbjct: 241 PDGCCLYSGCQD 252
Score = 57.0 bits (136), Expect = 4e-08
Identities = 36/148 (24%), Positives = 74/148 (50%), Gaps = 6/148 (4%)
Query: 326 QLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385
+LLA+GG+D ++ +W+ + + + T H + V+++ + + ++A G+ IR W
Sbjct: 34 RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVA---GSQSGSIRVW 90
Query: 386 NTLTGQPLQCI-DTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSY 444
+ + L+ + + +C+L + + + S G I +W V + GHS
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVAS--GSQDTNIKLWDIRRKGCVFRYRGHSQ 148
Query: 445 RVLYLAMSPDGEAIVTGAGDETLRFWNV 472
V L SPDG+ + + A D T++ W++
Sbjct: 149 AVRCLRFSPDGKWLASAADDHTVKLWDL 176
Score = 38.1 bits (87), Expect = 0.018
Identities = 28/129 (21%), Positives = 50/129 (38%), Gaps = 5/129 (3%)
Query: 348 VQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRC-IRFWNTLTGQPLQCIDTGSQVCNLA 406
+Q+ H + V ++ LLA+GG D C + W+ + + +
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGG---DDCRVNLWSINKPNCIMSLTGHTSPVESV 69
Query: 407 WSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDET 466
EL+ G I VW + + L GH + L P GE + +G+ D
Sbjct: 70 RLNTPEELIVA-GSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTN 128
Query: 467 LRFWNVFSK 475
++ W++ K
Sbjct: 129 IKLWDIRRK 137
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 73.2 bits (178), Expect = 5e-13
Identities = 68/277 (24%), Positives = 122/277 (44%), Gaps = 19/277 (6%)
Query: 223 CDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE 282
C L ++V+SV +S G +A + + IW A GK L GH + +AW+++
Sbjct: 35 CTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD 94
Query: 283 --QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 340
+L S S D+ + D+R+ + + L+GH V ++ L+ SG D + +W
Sbjct: 95 SSRLVSASDDKTLKLWDVRSG--KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 341 NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DT 398
+ ++ + H V A+ ++ L+ S G+ D R W+ +GQ L+ + D
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFN-CSGSLIVS--GSYDGLCRIWDAASGQCLKTLVDDD 209
Query: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH---SYRVLYLAMSPDG 455
V + +S + +++ N + +W Y + TGH Y + G
Sbjct: 210 NPPVSFVKFSPNGKYILT--ATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG 267
Query: 456 EAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRI 492
+ IV+G+ D + WN+ TKE V L T +
Sbjct: 268 KWIVSGSEDNLVYIWNL-----QTKEIVQKLQGHTDV 299
Score = 67.4 bits (163), Expect = 3e-11
Identities = 57/249 (22%), Positives = 109/249 (43%), Gaps = 18/249 (7%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 289
++ V WS + + + +++WD +GK L L+GH+ V +N + + SGS
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349
D + +++T + + L H V + ++ L+ SG D +W+ +S ++
Sbjct: 146 DETVKIWEVKTG--KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 350 QYTEH-LAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 408
+ V + +SP+ +L + T D ++ W+ G+ C+ T + N +
Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTA---TLDNTLKLWDYSRGR---CLKTYTGHKNEKYC 257
Query: 409 KHANELVS-----THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA- 462
AN V+ G N + +W + V KL GH+ V+ A P I + A
Sbjct: 258 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAL 317
Query: 463 -GDETLRFW 470
D+T++ W
Sbjct: 318 ENDKTIKLW 326
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/198 (24%), Positives = 86/198 (43%), Gaps = 23/198 (11%)
Query: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAA 259
++S V +W T + + LS D V++V ++ G+L+ G++ G +IWDAA
Sbjct: 140 IISGSFDETVKIWEVKTGKCLKT--LSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 260 AGKKLSML---EGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE- 315
+G+ L L + + N + + + + D + D + + GH+ E
Sbjct: 198 SGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRG--RCLKTYTGHKNEK 255
Query: 316 --------VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367
V G KW + SG DN + +WN + VQ+ H V + A P +
Sbjct: 256 YCIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTE 309
Query: 368 HGLLASGGGTADRCIRFW 385
+ L+AS D+ I+ W
Sbjct: 310 N-LIASAALENDKTIKLW 326
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 72.0 bits (175), Expect = 1e-12
Identities = 72/287 (25%), Positives = 123/287 (42%), Gaps = 22/287 (7%)
Query: 193 VDWS--SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHK 250
VD+S + + S + +C+ +W +R + D+VT V +S G+L+A G+
Sbjct: 25 VDFSINTKQLASGSMDSCLMVWHM--KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRD 82
Query: 251 GFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERR-- 308
V+IW + ++ HTA V ++ + ++ S + D +T + + R
Sbjct: 83 KTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS------FVTASDDKTVKVWATHRQK 136
Query: 309 ----LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWS 364
L H V K+S D +L+ S +D + +W+ SS V Y EH V + +
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH 196
Query: 365 PHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCN-LAWSKHANELVSTHGYSQN 423
P + A+G D ++ W+ T + LQ S N L++ N L++ S
Sbjct: 197 PSGTCIAAAG---MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 424 QILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470
+IL L + L GH +A S GE +G DE + W
Sbjct: 254 KILDLMEGRL--LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 67.0 bits (162), Expect = 4e-11
Identities = 49/171 (28%), Positives = 81/171 (47%), Gaps = 6/171 (3%)
Query: 306 ERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSP 365
ER +GHR V + +S + + LASG D+ L+VW+ S ++T H AV + +SP
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 366 HQHGLLASGGGTADRCIRFW-NTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQ 424
H LLAS G+ D+ +R W + G+ + V ++ + V+
Sbjct: 72 SGH-LLAS--GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS--DDKT 126
Query: 425 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 475
+ VW + L+ H V SPDG IV+ + D+T++ W+ S+
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Score = 37.7 bits (86), Expect = 0.024
Identities = 18/61 (29%), Positives = 30/61 (49%)
Query: 419 GYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 478
G + ++VW ++ + TGH V + SP G + +G+ D+T+R W K S
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Query: 479 T 479
T
Sbjct: 97 T 97
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 72.0 bits (175), Expect = 1e-12
Identities = 72/287 (25%), Positives = 123/287 (42%), Gaps = 22/287 (7%)
Query: 193 VDWS--SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHK 250
VD+S + + S + +C+ +W +R + D+VT V +S G+L+A G+
Sbjct: 25 VDFSINTKQLASGSMDSCLMVWHM--KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRD 82
Query: 251 GFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERR-- 308
V+IW + ++ HTA V ++ + ++ S + D +T + + R
Sbjct: 83 KTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS------FVTASDDKTVKVWATHRQK 136
Query: 309 ----LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWS 364
L H V K+S D +L+ S +D + +W+ SS V Y EH V + +
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH 196
Query: 365 PHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCN-LAWSKHANELVSTHGYSQN 423
P + A+G D ++ W+ T + LQ S N L++ N L++ S
Sbjct: 197 PSGTCIAAAG---MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 424 QILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470
+IL L + L GH +A S GE +G DE + W
Sbjct: 254 KILDLMEGRL--LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 67.0 bits (162), Expect = 4e-11
Identities = 49/171 (28%), Positives = 81/171 (47%), Gaps = 6/171 (3%)
Query: 306 ERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSP 365
ER +GHR V + +S + + LASG D+ L+VW+ S ++T H AV + +SP
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 366 HQHGLLASGGGTADRCIRFW-NTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQ 424
H LLAS G+ D+ +R W + G+ + V ++ + V+
Sbjct: 72 SGH-LLAS--GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS--DDKT 126
Query: 425 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 475
+ VW + L+ H V SPDG IV+ + D+T++ W+ S+
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Score = 37.7 bits (86), Expect = 0.024
Identities = 18/61 (29%), Positives = 30/61 (49%)
Query: 419 GYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 478
G + ++VW ++ + TGH V + SP G + +G+ D+T+R W K S
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Query: 479 T 479
T
Sbjct: 97 T 97
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 72.0 bits (175), Expect = 1e-12
Identities = 56/228 (24%), Positives = 100/228 (43%), Gaps = 19/228 (8%)
Query: 251 GFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRL- 309
G V++W + + ++ +EGHT RV + W+ G+ R R L+++ +
Sbjct: 303 GSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTT---CYDRSWRLWDLEAQEEIL 359
Query: 310 --QGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367
+GH V + + D L +GG D VW+ + + HL + I +SP+
Sbjct: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419
Query: 368 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSK-----HANELVSTHGYSQ 422
+ + G+ D + W+ + +C+ T NL H N L++ G
Sbjct: 420 YHIAT---GSGDNTCKVWDL---RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLT--GAYD 471
Query: 423 NQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470
N +W +P + + L GH +V+ L +S DG+ I T + D T + W
Sbjct: 472 NTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 57.4 bits (137), Expect = 3e-08
Identities = 44/168 (26%), Positives = 72/168 (42%), Gaps = 22/168 (13%)
Query: 210 YLWSACTSQVTRLCDLSV-------EGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAA 260
+L + C + RL DL EG S V + + + G+L G F ++WD
Sbjct: 337 FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 396
Query: 261 GKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERR----LQGHRQ 314
G+ + LEGH + + + N +++GS D D+R +RR + H+
Sbjct: 397 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR------QRRCVYTIPAHQN 450
Query: 315 EVCGLKWSTDH-QLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAI 361
V G+K+ H L +G DN +W H SP++ H V +
Sbjct: 451 LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGL 498
Score = 50.1 bits (118), Expect = 5e-06
Identities = 50/244 (20%), Positives = 85/244 (34%), Gaps = 54/244 (22%)
Query: 237 WSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQR 296
+S ++A G ++W L L GH VGA+ ++ + S + L
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 297 -----DIRTPPLQSERR---LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348
++ L S+ ++GH V + W + L + D +W+ + +
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
Query: 349 QQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 408
H V IA+ HQ G LA GG D R W+ TG+ + ++
Sbjct: 359 LHQEGHSMGVYDIAF--HQDGSLAGTGGL-DAFGRVWDLRTGRCIMFLE----------- 404
Query: 409 KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLR 468
GH + + SP+G I TG+GD T +
Sbjct: 405 --------------------------------GHLKEIYGINFSPNGYHIATGSGDNTCK 432
Query: 469 FWNV 472
W++
Sbjct: 433 VWDL 436
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 72.0 bits (175), Expect = 1e-12
Identities = 44/134 (32%), Positives = 67/134 (50%), Gaps = 5/134 (3%)
Query: 209 VYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLE 268
++LWS + L ++ + V +S +VA + +++WD GK L+ L
Sbjct: 61 LFLWSPAEDKKP-LTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLR 119
Query: 269 GHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQ 326
GH A V +AW+A+ L SGS D + D++ L + L GH EV + WS D Q
Sbjct: 120 GHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD--LPGHADEVYAVDWSPDGQ 177
Query: 327 LLASGGNDNKLLVW 340
+ASGG D L +W
Sbjct: 178 RVASGGKDKCLRIW 191
Score = 65.5 bits (158), Expect = 1e-10
Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 7/145 (4%)
Query: 328 LASGGNDNKLLVWNHSS-LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWN 386
L SG +D L +W+ + P+ + T H A + + +SP ++AS + D+ I+ W+
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSR-IVASA--SFDKSIKLWD 108
Query: 387 TLTGQPLQCIDTG-SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYR 445
TG+ L + + V +AWS + LVS G S + + VW + L GH+
Sbjct: 109 GRTGKYLASLRGHVAAVYQIAWSADSRLLVS--GSSDSTLKVWDVKAQKLAMDLPGHADE 166
Query: 446 VLYLAMSPDGEAIVTGAGDETLRFW 470
V + SPDG+ + +G D+ LR W
Sbjct: 167 VYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 64.3 bits (155), Expect = 2e-10
Identities = 44/134 (32%), Positives = 67/134 (50%), Gaps = 8/134 (5%)
Query: 255 IWDAAAGKK-LSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQG 311
+W A KK L+ + GH A + + ++ + ++S S D+ I D RT + L+G
Sbjct: 63 LWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS--LRG 120
Query: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 371
H V + WS D +LL SG +D+ L VW+ + H V A+ WSP +
Sbjct: 121 HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ-RV 179
Query: 372 ASGGGTADRCIRFW 385
ASGG D+C+R W
Sbjct: 180 ASGG--KDKCLRIW 191
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 71.6 bits (174), Expect = 2e-12
Identities = 66/269 (24%), Positives = 113/269 (42%), Gaps = 17/269 (6%)
Query: 211 LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGK---KLSM- 266
+W + T+ ++ + + V + ++ GN VA G I++ + ++S
Sbjct: 81 IWDSYTTN--KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRE 138
Query: 267 LEGHTARVGALAW-NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH 325
L GHT + + + Q+ + S D DI T Q GH +V L + D
Sbjct: 139 LAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMSLSLAPDT 196
Query: 326 QLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385
+L SG D +W+ Q +T H + + AI + P+ + A G+ D R +
Sbjct: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN---AFATGSDDATCRLF 253
Query: 386 NTLTGQPLQCIDTGSQVCNL---AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH 442
+ Q L + +C + ++SK L++ GY VW + L GH
Sbjct: 254 DLRADQELMTYSHDNIICGITSVSFSKSGRLLLA--GYDDFNCNVWDALKADRAGVLAGH 311
Query: 443 SYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
RV L ++ DG A+ TG+ D L+ WN
Sbjct: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/179 (25%), Positives = 79/179 (44%), Gaps = 19/179 (10%)
Query: 303 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 362
+++ R L+GH ++ + W TD +LL S D KL++W+ + + V + V A
Sbjct: 45 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 104
Query: 363 WSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQ 422
++P +A GG D +N T + G+ + + H L
Sbjct: 105 YAP-SGNYVACGG--LDNICSIYNLKTRE-------GNVRVSRELAGHTGYLSCCRFLDD 154
Query: 423 NQIL---------VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
NQI+ +W + Q TGH+ V+ L+++PD V+GA D + + W+V
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 71.2 bits (173), Expect = 2e-12
Identities = 68/273 (24%), Positives = 116/273 (42%), Gaps = 20/273 (7%)
Query: 205 LGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKL 264
+ +C+ +W +R + D+VT V +S G+L+A G+ V+IW +
Sbjct: 1 MDSCLMVWHM--KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 58
Query: 265 SMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERR------LQGHRQEVCG 318
++ HTA V ++ + ++ S + D +T + + R L H V
Sbjct: 59 TVFRAHTATVRSVHFCSDGQS------FVTASDDKTVKVWATHRQKFLFSLSQHINWVRC 112
Query: 319 LKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTA 378
K+S D +L+ S +D + +W+ SS V Y EH V + + P + A+G
Sbjct: 113 AKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG---M 169
Query: 379 DRCIRFWNTLTGQPLQCIDTGSQVCN-LAWSKHANELVSTHGYSQNQILVWKYPSLTQVA 437
D ++ W+ T + LQ S N L++ N L++ S +IL L +
Sbjct: 170 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL--LY 227
Query: 438 KLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470
L GH +A S GE +G DE + W
Sbjct: 228 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/143 (26%), Positives = 65/143 (45%), Gaps = 6/143 (4%)
Query: 334 DNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW-NTLTGQP 392
D+ L+VW+ S ++T H AV + +SP H LLASG + D+ +R W + G+
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH-LLASG--SRDKTVRIWVPNVKGES 58
Query: 393 LQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMS 452
+ V ++ + V+ + VW + L+ H V S
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTAS--DDKTVKVWATHRQKFLFSLSQHINWVRCAKFS 116
Query: 453 PDGEAIVTGAGDETLRFWNVFSK 475
PDG IV+ + D+T++ W+ S+
Sbjct: 117 PDGRLIVSASDDKTVKLWDKSSR 139
Score = 44.7 bits (104), Expect = 2e-04
Identities = 37/172 (21%), Positives = 63/172 (36%), Gaps = 6/172 (3%)
Query: 302 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAI 361
P R GH+ V + +S LLASG D + +W + + H A V+++
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 71
Query: 362 AWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLA-WSKHANELVSTHGY 420
+ + + D+ ++ W T + L + A +S +VS
Sbjct: 72 HFCSDGQSFVTASD---DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS-- 126
Query: 421 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
+ +W S V H V Y+ P G I D T++ W+V
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Score = 37.4 bits (85), Expect = 0.031
Identities = 17/55 (30%), Positives = 28/55 (50%)
Query: 425 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRST 479
++VW ++ + TGH V + SP G + +G+ D+T+R W K ST
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 19/254 (7%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 289
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + S
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349
D+ + D T +++++ H + W ++ AS D + V PV+
Sbjct: 299 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 355
Query: 350 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 408
+ H V AI W P G+L + + D ++ W+ + + ++ + WS
Sbjct: 356 TFQGHTNEVNAIKWDP--SGMLLA-SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 412
Query: 409 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 460
++N ++++ + + + +W LT H V +A SPDG+ + +
Sbjct: 413 PTGPATSNPNSNIMLASASF-DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 471
Query: 461 GAGDETLRFWNVFS 474
G+ D+ + WN S
Sbjct: 472 GSFDKCVHIWNTQS 485
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/226 (22%), Positives = 90/226 (39%), Gaps = 25/226 (11%)
Query: 252 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 311
F+ W+ + S TAR+ WN + S+G +++L+ IR G
Sbjct: 185 FICAWNPVSDLLASGSGDSTARI----WNLNENSNGGSTQLVLRHCIREG---------G 231
Query: 312 H----RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367
H ++V L W+T+ LLA+G D +W + +H + A+ W+
Sbjct: 232 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKG 290
Query: 368 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQIL 426
+ +L++G D+ W+ TG+ Q S ++ W N + I
Sbjct: 291 NYILSAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NNTTFASCSTDMCIH 344
Query: 427 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
V + V GH+ V + P G + + + D TL+ W++
Sbjct: 345 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 390
Score = 39.3 bits (90), Expect = 0.008
Identities = 42/177 (23%), Positives = 69/177 (38%), Gaps = 28/177 (15%)
Query: 193 VDW-SSLNVLSVGLGTCVYLWSACTSQVTRL-CDLSVEG-----DSVTSVGWSERGNLVA 245
VDW ++ S C++ V RL CD V+ + V ++ W G L+A
Sbjct: 326 VDWQNNTTFASCSTDMCIH--------VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLA 377
Query: 246 VGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE-----------QLSSGSRDRMIL 294
+ ++IW + L+ H + + W+ L+S S D +
Sbjct: 378 SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVR 437
Query: 295 QRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY 351
DI L H++ V + +S D + LASG D + +WN S + V Y
Sbjct: 438 LWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSY 492
Score = 33.5 bits (75), Expect = 0.45
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 439 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
L GH V A +P + + +G+GD T R WN+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL 210
Score = 32.3 bits (72), Expect = 1.0
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 309 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
L+GH EV W+ LLASG D+ +WN
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 209
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 19/254 (7%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 289
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + S
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349
D+ + D T +++++ H + W ++ AS D + V PV+
Sbjct: 299 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 355
Query: 350 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 408
+ H V AI W P G+L + + D ++ W+ + + ++ + WS
Sbjct: 356 TFQGHTNEVNAIKWDP--SGMLLA-SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 412
Query: 409 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 460
++N ++++ + + + +W LT H V +A SPDG+ + +
Sbjct: 413 PTGPATSNPNSNIMLASASF-DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 471
Query: 461 GAGDETLRFWNVFS 474
G+ D+ + WN S
Sbjct: 472 GSFDKCVHIWNTQS 485
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/226 (22%), Positives = 90/226 (39%), Gaps = 25/226 (11%)
Query: 252 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 311
F+ W+ + S TAR+ WN + S+G +++L+ IR G
Sbjct: 185 FICAWNPVSDLLASGSGDSTARI----WNLNENSNGGSTQLVLRHCIREG---------G 231
Query: 312 H----RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367
H ++V L W+T+ LLA+G D +W + +H + A+ W+
Sbjct: 232 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKG 290
Query: 368 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQIL 426
+ +L++G D+ W+ TG+ Q S ++ W N + I
Sbjct: 291 NYILSAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NNTTFASCSTDMCIH 344
Query: 427 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
V + V GH+ V + P G + + + D TL+ W++
Sbjct: 345 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 390
Score = 39.3 bits (90), Expect = 0.008
Identities = 42/177 (23%), Positives = 69/177 (38%), Gaps = 28/177 (15%)
Query: 193 VDW-SSLNVLSVGLGTCVYLWSACTSQVTRL-CDLSVEG-----DSVTSVGWSERGNLVA 245
VDW ++ S C++ V RL CD V+ + V ++ W G L+A
Sbjct: 326 VDWQNNTTFASCSTDMCIH--------VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLA 377
Query: 246 VGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE-----------QLSSGSRDRMIL 294
+ ++IW + L+ H + + W+ L+S S D +
Sbjct: 378 SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVR 437
Query: 295 QRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY 351
DI L H++ V + +S D + LASG D + +WN S + V Y
Sbjct: 438 LWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSY 492
Score = 33.5 bits (75), Expect = 0.45
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 439 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
L GH V A +P + + +G+GD T R WN+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL 210
Score = 32.3 bits (72), Expect = 1.0
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 309 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
L+GH EV W+ LLASG D+ +WN
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 209
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 19/254 (7%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 289
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + S
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349
D+ + D T +++++ H + W ++ AS D + V PV+
Sbjct: 350 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 406
Query: 350 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 408
+ H V AI W P G+L + + D ++ W+ + + ++ + WS
Sbjct: 407 TFQGHTNEVNAIKWDP--SGMLLA-SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
Query: 409 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 460
++N ++++ + + + +W LT H V +A SPDG+ + +
Sbjct: 464 PTGPATSNPNSNIMLASASF-DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
Query: 461 GAGDETLRFWNVFS 474
G+ D+ + WN S
Sbjct: 523 GSFDKCVHIWNTQS 536
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/226 (22%), Positives = 90/226 (39%), Gaps = 25/226 (11%)
Query: 252 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 311
F+ W+ + S TAR+ WN + S+G +++L+ IR G
Sbjct: 236 FICAWNPVSDLLASGSGDSTARI----WNLNENSNGGSTQLVLRHCIREG---------G 282
Query: 312 H----RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367
H ++V L W+T+ LLA+G D +W + +H + A+ W+
Sbjct: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKG 341
Query: 368 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQIL 426
+ +L++G D+ W+ TG+ Q S ++ W N + I
Sbjct: 342 NYILSAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NNTTFASCSTDMCIH 395
Query: 427 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
V + V GH+ V + P G + + + D TL+ W++
Sbjct: 396 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 441
Score = 39.3 bits (90), Expect = 0.008
Identities = 42/177 (23%), Positives = 69/177 (38%), Gaps = 28/177 (15%)
Query: 193 VDW-SSLNVLSVGLGTCVYLWSACTSQVTRL-CDLSVEG-----DSVTSVGWSERGNLVA 245
VDW ++ S C++ V RL CD V+ + V ++ W G L+A
Sbjct: 377 VDWQNNTTFASCSTDMCIH--------VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLA 428
Query: 246 VGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE-----------QLSSGSRDRMIL 294
+ ++IW + L+ H + + W+ L+S S D +
Sbjct: 429 SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVR 488
Query: 295 QRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY 351
DI L H++ V + +S D + LASG D + +WN S + V Y
Sbjct: 489 LWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSY 543
Score = 33.5 bits (75), Expect = 0.45
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 439 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
L GH V A +P + + +G+GD T R WN+
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL 261
Score = 32.3 bits (72), Expect = 1.0
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 309 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
L+GH EV W+ LLASG D+ +WN
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 260
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 19/254 (7%)
Query: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN--AEQLSSGSR 289
VTS+ W+ G L+A G++ GF +IW G S L H + AL WN + S
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
Query: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349
D+ + D T +++++ H + W ++ AS D + V PV+
Sbjct: 350 DKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 406
Query: 350 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 408
+ H V AI W P G+L + + D ++ W+ + + ++ + WS
Sbjct: 407 TFQGHTNEVNAIKWDP--SGMLLA-SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
Query: 409 --------KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 460
++N ++++ + + + +W LT H V +A SPDG+ + +
Sbjct: 464 PTGPATSNPNSNIMLASASF-DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
Query: 461 GAGDETLRFWNVFS 474
G+ D+ + WN S
Sbjct: 523 GSFDKCVHIWNTQS 536
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/226 (22%), Positives = 90/226 (39%), Gaps = 25/226 (11%)
Query: 252 FVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 311
F+ W+ + S TAR+ WN + S+G +++L+ IR G
Sbjct: 236 FICAWNPVSDLLASGSGDSTARI----WNLNENSNGGSTQLVLRHCIREG---------G 282
Query: 312 H----RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367
H ++V L W+T+ LLA+G D +W + +H + A+ W+
Sbjct: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKG 341
Query: 368 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS-QVCNLAWSKHANELVSTHGYSQNQIL 426
+ +L++G D+ W+ TG+ Q S ++ W N + I
Sbjct: 342 NYILSAG---VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ---NNTTFASCSTDMCIH 395
Query: 427 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
V + V GH+ V + P G + + + D TL+ W++
Sbjct: 396 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM 441
Score = 39.3 bits (90), Expect = 0.008
Identities = 42/177 (23%), Positives = 69/177 (38%), Gaps = 28/177 (15%)
Query: 193 VDW-SSLNVLSVGLGTCVYLWSACTSQVTRL-CDLSVEG-----DSVTSVGWSERGNLVA 245
VDW ++ S C++ V RL CD V+ + V ++ W G L+A
Sbjct: 377 VDWQNNTTFASCSTDMCIH--------VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLA 428
Query: 246 VGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE-----------QLSSGSRDRMIL 294
+ ++IW + L+ H + + W+ L+S S D +
Sbjct: 429 SCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVR 488
Query: 295 QRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY 351
DI L H++ V + +S D + LASG D + +WN S + V Y
Sbjct: 489 LWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSY 543
Score = 33.5 bits (75), Expect = 0.45
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 439 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
L GH V A +P + + +G+GD T R WN+
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL 261
Score = 32.3 bits (72), Expect = 1.0
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 309 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
L+GH EV W+ LLASG D+ +WN
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 260
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 70.9 bits (172), Expect = 3e-12
Identities = 67/269 (24%), Positives = 112/269 (41%), Gaps = 17/269 (6%)
Query: 211 LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGK---KLSM- 266
+W + T+ ++ + + V + ++ GN VA G I++ + + K+S
Sbjct: 81 VWDSYTTN--KVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRE 138
Query: 267 LEGHTARVGALAW-NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH 325
L HT + + + + + S D DI T Q + GH + L S D
Sbjct: 139 LSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETG--QQKTVFVGHTGDCMSLAVSPDF 196
Query: 326 QLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385
L SG D +W+ + Q +T H + + AI + P+ + G+ D R +
Sbjct: 197 NLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICT---GSDDASCRLF 253
Query: 386 NTLTGQPLQCIDTGSQVCNL---AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH 442
+ Q L C S +C + A+S L + GY VW +V L+GH
Sbjct: 254 DLRADQELICFSHESIICGITSVAFSLSGRLLFA--GYDDFNCNVWDSMKSERVGILSGH 311
Query: 443 SYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
RV L ++ DG A+ TG+ D L+ WN
Sbjct: 312 DNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 62.0 bits (149), Expect = 1e-09
Identities = 44/176 (25%), Positives = 76/176 (43%), Gaps = 13/176 (7%)
Query: 303 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 362
+++ R L+GH ++ + W+TD +LL S D KL+VW+ + + V + V A
Sbjct: 45 MRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCA 104
Query: 363 WSPHQHGLLASGGGTADRC------IRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVS 416
++P G + GG + C R N + L C N +V+
Sbjct: 105 YAP--SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFL---DDNNIVT 159
Query: 417 THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
+ G +W + Q GH+ + LA+SPD ++GA D + + W+V
Sbjct: 160 SSG--DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDV 213
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 69.3 bits (168), Expect = 7e-12
Identities = 52/211 (24%), Positives = 95/211 (45%), Gaps = 7/211 (3%)
Query: 264 LSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKW 321
+ +L GH V + N L+S DR+IL ++ + L+GH V L +
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-CDNYATLKGHSGAVMELHY 117
Query: 322 STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRC 381
+TD +L S D + VW+ + V++ H + V + P + G G+ D
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY--PARRGPQLVCTGSDDGT 175
Query: 382 IRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTG 441
++ W+ +Q QV + ++ +++++S G N I VW + G
Sbjct: 176 VKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIIS--GGIDNDIKVWDLRQNKLTYTMRG 233
Query: 442 HSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
H+ V L++S +G +++ A D T+R W+V
Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDV 264
Score = 62.4 bits (150), Expect = 9e-10
Identities = 61/281 (21%), Positives = 119/281 (42%), Gaps = 27/281 (9%)
Query: 202 SVGLGTCVYLWSA---CTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDA 258
S G + LW+ C + T L +V + ++ G+++ + V +WD+
Sbjct: 83 SAGFDRLILLWNVYGDCDNYAT----LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDS 138
Query: 259 AAGKKLSMLEGHTARVGAL--AWNAEQL-SSGSRDRMILQRDIRTPPLQSERRLQGHRQE 315
G+++ L+GHT+ V + A QL +GS D + DIR ++ + + +
Sbjct: 139 ETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK---KAAIQTFQNTYQ 195
Query: 316 VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGG 375
V + ++ + SGG DN + VW+ H +V ++ S LL++
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN-- 253
Query: 376 GTADRCIRFWNTLTGQPLQ-CI--------DTGSQVCNLAWSKHANELVSTHGYSQNQIL 426
D +R W+ P + C+ + + +WS +++ + G + +
Sbjct: 254 -AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA--GSADRFVY 310
Query: 427 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETL 467
VW S + KL GH+ + +A PD I++ + D+ L
Sbjct: 311 VWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/199 (26%), Positives = 86/199 (43%), Gaps = 19/199 (9%)
Query: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERG-NLVAVGTHKGFVQIWDA 258
+ S V +W + T + R+ L V S + RG LV G+ G V++WD
Sbjct: 124 LFSASTDKTVAVWDSETGE--RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 259 AAGKKLSMLEGHTARVGALAWN--AEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEV 316
+ + +T +V A+ +N ++Q+ SG D I D+R L R GH V
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR--GHADSV 238
Query: 317 CGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA--------VKAIAWSPHQH 368
GL S++ L S DN + VW+ +P ++ + + +WSP
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
Query: 369 GLLASGGGTADRCIRFWNT 387
+ A G+ADR + W+T
Sbjct: 299 KIAA---GSADRFVYVWDT 314
Score = 38.9 bits (89), Expect = 0.011
Identities = 18/65 (27%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 237 WSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMIL 294
WS G+ +A G+ FV +WD + + L L GH + +A++ ++ + S S D+ +
Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLY 352
Query: 295 QRDIR 299
+I+
Sbjct: 353 MGEIQ 357
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,974,404
Number of Sequences: 37866
Number of extensions: 941355
Number of successful extensions: 5010
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 2936
Number of HSP's gapped (non-prelim): 1202
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.