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Search of human proteins with 33519481
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
(837 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 1679 0.0
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 708 0.0
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 705 0.0
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 566 e-161
gi|110349719 titin isoform N2-A [Homo sapiens] 171 2e-42
gi|118572606 hemicentin 1 [Homo sapiens] 162 9e-40
gi|119220552 sidekick 1 [Homo sapiens] 162 1e-39
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 161 2e-39
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 160 3e-39
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 153 6e-37
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 151 3e-36
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 151 3e-36
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 148 2e-35
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 148 2e-35
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 148 2e-35
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 148 2e-35
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 148 2e-35
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 147 4e-35
gi|7657359 contactin 5 isoform long [Homo sapiens] 147 4e-35
gi|28373129 contactin 5 isoform short [Homo sapiens] 147 4e-35
gi|19743806 roundabout 1 isoform b [Homo sapiens] 147 5e-35
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 147 5e-35
gi|109150416 peroxidasin [Homo sapiens] 145 2e-34
gi|224994173 roundabout 1 isoform d [Homo sapiens] 144 4e-34
gi|224994171 roundabout 1 isoform c [Homo sapiens] 144 4e-34
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 144 4e-34
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 144 4e-34
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 142 1e-33
gi|4506569 roundabout 1 isoform a [Homo sapiens] 142 2e-33
gi|126517478 peroxidasin homolog-like [Homo sapiens] 142 2e-33
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 1679 bits (4348), Expect = 0.0
Identities = 837/837 (100%), Positives = 837/837 (100%)
Query: 1 MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEK 60
MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEK
Sbjct: 1 MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEK 60
Query: 61 IISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREV 120
IISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREV
Sbjct: 61 IISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREV 120
Query: 121 VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSD 180
VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSD
Sbjct: 121 VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSD 180
Query: 181 EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP 240
EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP
Sbjct: 181 EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP 240
Query: 241 AISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV 300
AISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV
Sbjct: 241 AISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV 300
Query: 301 QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH 360
QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH
Sbjct: 301 QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH 360
Query: 361 GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINI 420
GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINI
Sbjct: 361 GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINI 420
Query: 421 SCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNH 480
SCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNH
Sbjct: 421 SCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNH 480
Query: 481 IGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE 540
IGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE
Sbjct: 481 IGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE 540
Query: 541 IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH 600
IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH
Sbjct: 541 IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH 600
Query: 601 GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTM 660
GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTM
Sbjct: 601 GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTM 660
Query: 661 GYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTD 720
GYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTD
Sbjct: 661 GYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTD 720
Query: 721 VSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVT 780
VSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVT
Sbjct: 721 VSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVT 780
Query: 781 NHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA 837
NHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA
Sbjct: 781 NHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA 837
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 708 bits (1828), Expect = 0.0
Identities = 383/855 (44%), Positives = 538/855 (62%), Gaps = 33/855 (3%)
Query: 3 LLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPES--IDWYNPQGEK 60
L+ + + LG VS LQV I S+ E+SVGESKFF C G+ + I W++P GEK
Sbjct: 7 LIWTLFFLGTAVS-----LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
Query: 61 IISTQR--VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR 118
+ Q+ VV + S LTIYNANI+DAGIY+C T G EATV ++I+QKL F+
Sbjct: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
Query: 119 EVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK 178
+PQEF++GEDA +VC V SS P + W + +V D RF +L+NN LQI I K
Sbjct: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
Query: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSP 238
+DEG YRCEGR+ ARGEI+F+DI VIVNVPP I Q NATA G+ +T C A G P
Sbjct: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
Query: 239 EPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
EP +SW ++G+ I E++EKYI +++LT++ + +D Y+C A NKAGE +
Sbjct: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
Query: 296 LQVFVQPHIIQLKNETTYE-NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI 354
L+VF +P I ++N+T E QVTL C+A G+PIP ITW+ + + E K+LDG +
Sbjct: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE--KTLDGHM 359
Query: 355 EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE 414
V+ SSL +K ++ +D+G Y C A++ IG +SMYL+++YAPK + Y+WE
Sbjct: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWE 418
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
GN +NI+C+V + P A+I W RD +LP+ N +N+K Y+T LE+ P S+NDFG YN
Sbjct: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
CTA N IG E+IL AD PSSP + +E +TA+V F++P++ GGVPI Y+ +
Sbjct: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
Query: 535 KEVASEIWKI----VRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLP 590
+ V E+W + ++ +V + L+P TTY +R+AA+NGKG G+ S F+T P
Sbjct: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
Query: 591 VR-EPSPPSIHGQ-PSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWL-EKKVQGN 647
V+ EPS P + GQ G S K+++ KQDDGG+PI Y+V+YR+ E W E ++
Sbjct: 598 VQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--WKPEIRLPSG 655
Query: 648 KDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNII--KDTLFNGLGLGAVI 705
DH++L+ L W YEV + A N+ G S+ + F +P I + +GL GA++
Sbjct: 656 SDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIV 715
Query: 706 GLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGS 765
G+ + +L+LVV D++C+F+ +CGL MCI +CG K+G K K++EEGKAA+ KD S
Sbjct: 716 GILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCG-KAGPGAKGKDMEEGKAAFSKDES 774
Query: 766 KEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPL--KEEDGKEALNPETIEIK- 822
KEPIVE+RTE+ER NH DG EPNETTPLTEPEK P+ K E + P E+K
Sbjct: 775 KEPIVEVRTEEERTPNH-DGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKT 833
Query: 823 VSNDIIQSKEDDSKA 837
V ND Q+KE++SKA
Sbjct: 834 VPNDATQTKENESKA 848
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 705 bits (1820), Expect = 0.0
Identities = 383/863 (44%), Positives = 539/863 (62%), Gaps = 39/863 (4%)
Query: 3 LLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPES--IDWYNPQGEK 60
L+ + + LG VS LQV I S+ E+SVGESKFF C G+ + I W++P GEK
Sbjct: 7 LIWTLFFLGTAVS-----LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
Query: 61 IISTQR--VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR 118
+ Q+ VV + S LTIYNANI+DAGIY+C T G EATV ++I+QKL F+
Sbjct: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
Query: 119 EVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK 178
+PQEF++GEDA +VC V SS P + W + +V D RF +L+NN LQI I K
Sbjct: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
Query: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSP 238
+DEG YRCEGR+ ARGEI+F+DI VIVNVPP I Q NATA G+ +T C A G P
Sbjct: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
Query: 239 EPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
EP +SW ++G+ I E++EKYI +++LT++ + +D Y+C A NKAGE +
Sbjct: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
Query: 296 LQVFVQPHIIQLKNETTYE-NGQVTLVCDAEGEPIPEITWKRAV--------DGFTFTEG 346
L+VF +P I ++N+T E QVTL C+A G+PIP ITW+ + +T E
Sbjct: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEK 361
Query: 347 DKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISN 406
++LDG + V+ SSL +K ++ +D+G Y C A++ IG +SMYL+++YAPK +
Sbjct: 362 QETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQG 420
Query: 407 QTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTS 466
Y+WEGN +NI+C+V + P A+I W RD +LP+ N +N+K Y+T LE+ P S
Sbjct: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
Query: 467 DNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526
+NDFG YNCTA N IG E+IL AD PSSP + +E +TA+V F++P++ GGVP
Sbjct: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVP 539
Query: 527 IHHYQVDVKEVASEIWKI----VRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSK 582
I Y+ + + V E+W + ++ +V + L+P TTY +R+AA+NGKG G+ S
Sbjct: 540 ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISA 599
Query: 583 IEIFQTLPVR-EPSPPSIHGQ-PSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWL 640
F+T PV+ EPS P + GQ G S K+++ KQDDGG+PI Y+V+YR+ E W
Sbjct: 600 ASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--WK 657
Query: 641 -EKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNII--KDTLFN 697
E ++ DH++L+ L W YEV + A N+ G S+ + F +P I + +
Sbjct: 658 PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTS 717
Query: 698 GLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGK 757
GL GA++G+ + +L+LVV D++C+F+ +CGL MCI +CG K+G K K++EEGK
Sbjct: 718 GLSTGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCG-KAGPGAKGKDMEEGK 776
Query: 758 AAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPL--KEEDGKEALN 815
AA+ KD SKEPIVE+RTE+ER NH DG EPNETTPLTEPEK P+ K E +
Sbjct: 777 AAFSKDESKEPIVEVRTEEERTPNH-DGGKHTEPNETTPLTEPEKGPVEAKPECQETETK 835
Query: 816 PETIEIK-VSNDIIQSKEDDSKA 837
P E+K V ND Q+KE++SKA
Sbjct: 836 PAPAEVKTVPNDATQTKENESKA 858
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 566 bits (1459), Expect = e-161
Identities = 313/765 (40%), Positives = 448/765 (58%), Gaps = 61/765 (7%)
Query: 3 LLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPES--IDWYNPQGEK 60
L+ + + LG VS LQV I S+ E+SVGESKFF C G+ + I W++P GEK
Sbjct: 7 LIWTLFFLGTAVS-----LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
Query: 61 IISTQR--VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR 118
+ Q+ VV + S LTIYNANI+DAGIY+C T G EATV ++I+QKL F+
Sbjct: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
Query: 119 EVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK 178
+PQEF++GEDA +VC V SS P + W + +V D RF +L+NN LQI I K
Sbjct: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
Query: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSP 238
+DEG YRCEGR+ ARGEI+F+DI VIVNVPP I Q NATA G+ +T C A G P
Sbjct: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
Query: 239 EPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
EP +SW ++G+ I E++EKYI +++LT++ + +D Y+C A NKAGE +
Sbjct: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
Query: 296 LQVFVQPHIIQLKNETTYE-NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI 354
L+VF +P I ++N+T E QVTL C+A G+PIP ITW+ + + E K+LDG +
Sbjct: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE--KTLDGHM 359
Query: 355 EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE 414
V+ SSL +K ++ +D+G Y C A++ IG +SMYL+++YAPK + Y+WE
Sbjct: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWE 418
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
GN +NI+C+V + P A+I W RD +LP+ N +N+K Y+T LE+ P S+NDFG YN
Sbjct: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
CTA N IG E+IL AD PSSP + +E +TA+V F++P++ GGVPI Y+ +
Sbjct: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
Query: 535 KEVASEIWKI----VRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLP 590
+ V E+W + ++ +V + L+P TTY +R+AA+NGKG G+ S F+T P
Sbjct: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
Query: 591 VREPSPPS---------------------------IHGQPSS----------GKSFKLSI 613
V P PP+ G+PS+ G S K+++
Sbjct: 598 VHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNL 657
Query: 614 TKQDDGGAPILEYIVKYRSKDKEDQWL-EKKVQGNKDHIILEHLQWTMGYEVQITAANRL 672
KQDDGG+PI Y+V+YR+ E W E ++ DH++L+ L W YEV + A N+
Sbjct: 658 IKQDDGGSPIRHYLVRYRALSSE--WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQ 715
Query: 673 GYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILV 717
G S+ + F +P I TL + L +A+ L+L+
Sbjct: 716 GKSKAAHFVFRTSAQPTAIPATLGGNSASYTFVSLLFSAVTLLLL 760
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 171 bits (434), Expect = 2e-42
Identities = 155/591 (26%), Positives = 243/591 (41%), Gaps = 41/591 (6%)
Query: 27 LSKVELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
LS + VG+ T G EP S+ W+ +GE + + + + + L
Sbjct: 7498 LSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEP 7557
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPA 145
+AG Y CQ + G QE L + + T E + G+ + C V+ +P +
Sbjct: 7558 ANAGKYTCQIKNDAGM-QECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELS 7616
Query: 146 VSWLYHNEEVTTISDNRFAMLANNN---LQILNINKSDEGIYRCE-----GRVEARGEID 197
W +E+T SDN++ + N L+I+N+ SD G+Y E G+ +
Sbjct: 7617 TKWFKDGKELT--SDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQ 7674
Query: 198 FRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKY 257
D VPP+ + K N + G + C+ GSP ++SWF G I KY
Sbjct: 7675 VSDR----TVPPSFTRKLKETNGLS--GSSVVMECKVYGSPPISVSWFHEGNEISSGRKY 7728
Query: 258 --ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYEN 315
L + LTV + SD G Y C ATN AG DE A L V P +Q +
Sbjct: 7729 QTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLT 7788
Query: 316 G-QVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSD 374
G VT +G P ++W + GD R V + + L + DV S
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSS--ELVPGD-----RCNVSLEDSVAELELFDVDTSQ 7841
Query: 375 SGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHW 434
SG Y C ++ G + +L I+ KF+ Y +G P+ + PP S+ W
Sbjct: 7842 SGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTW 7901
Query: 435 RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALAD 494
+++ + + N+ T T + ILEI ++ D G+YNC N G ++ A
Sbjct: 7902 KKNGINVTPSQRCNITT--TEKSAILEIPSSTVEDAGQYNCYIENASG---KDSCSAQIL 7956
Query: 495 VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP---IHHYQVDVKEVASEIWKIVRSHGVQ 551
+ PY VK +E + + S + G P + Y+ D K + +K+ + V
Sbjct: 7957 ILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVA 8016
Query: 552 TMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQ 602
T+ V N ++ N + E A N G+ S Q + PPS Q
Sbjct: 8017 TL-VFNQVDINDSGEYICKAENSVGEVSASTFLTVQ----EQKLPPSFSRQ 8062
Score = 140 bits (352), Expect = 6e-33
Identities = 147/599 (24%), Positives = 252/599 (42%), Gaps = 44/599 (7%)
Query: 30 VELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
+++ GES F C G +P I W + ++I + G L I D+
Sbjct: 6280 IDVIAGESADFECHVTGAQPMRITW-SKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDS 6338
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTF-REVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
G Y CQAT+ G+ + L + + F +++ + + KQGE ++ C++S SP VS
Sbjct: 6339 GQYTCQATNDVGKDM-CSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVS 6397
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKS---DEGIYRCEGRVEARGEIDFRDIIVI 204
W ++ E+ ++ M N++ +L IN++ D G Y CE G+ +
Sbjct: 6398 WFRNDSELH--ESWKYNMSFINSVALLTINEASAEDSGDYICEAH-NGVGDASCSTALT- 6453
Query: 205 VNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYIL--KGS 262
V PP + QK A +G ++ C SG+P + W ++ K + ++K+ + K
Sbjct: 6454 VKAPPVFT--QKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHF 6511
Query: 263 NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ-LKNETTYENGQVTLV 321
+T L + N+ SD G Y C+ATN+ G D ++ P ++ L + +T V L
Sbjct: 6512 DTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELR 6571
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 381
EG + W + G E + + I+ ++L + + S+SG+Y C+
Sbjct: 6572 AIVEGFQPISVVWLKD-RGEVIRESENTRISFID-----NIATLQLGSPEASNSGKYICQ 6625
Query: 382 AASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVL 441
+ G + S L + + I GNP + C V P S W +D L
Sbjct: 6626 IKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGREL 6685
Query: 442 PAKNTTNLKTYSTGRKMILEIAPTSD---------NDFGRYNCTATNHIGTRF--QEYIL 490
A + ++ + + + A SD N G+ NCT + H+ R +I
Sbjct: 6686 SADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIR 6745
Query: 491 ALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGV 550
L DV ++ G ++ +VS + P S G +Q + V+ + S V
Sbjct: 6746 KLKDV-NAILGASVV----LECRVSGSAPISVG-----WFQDGNEIVSGPKCQSSFSENV 6795
Query: 551 QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSF 609
T+ L+ LEP+ T A N G + S + Q P E +P S+ P +F
Sbjct: 6796 CTL-NLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTF 6853
Score = 139 bits (351), Expect = 8e-33
Identities = 117/489 (23%), Positives = 203/489 (41%), Gaps = 47/489 (9%)
Query: 27 LSKVELSVGESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
L +E +VG TC G P + WY G + + + + L I ++
Sbjct: 6181 LKDIEQTVGLPVTLTCRLNGSAPIQVCWYR-DGVLLRDDENLQTSFVDNVATLKILQTDL 6239
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK---------QGEDAEVVC 136
+G Y C A++ G + +LT RE F GE A+ C
Sbjct: 6240 SHSGQYSCSASNPLGTASSSA-------RLTAREPKKSPFFDIKPVSIDVIAGESADFEC 6292
Query: 137 RVSSSPAPAVSWLYHNEEVTTISDNRFAMLANN-NLQILNINKSDEGIYRCEGRVEARGE 195
V+ + ++W N+E+ + + N +L+IL + K D G Y C+ +
Sbjct: 6293 HVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGK- 6351
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE 255
D + V PP + + + A++GE + C+ SGSPE +SWFRN + E+
Sbjct: 6352 -DMCSAQLSVKEPPKF-VKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESW 6409
Query: 256 KYILKGSNTE--LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNET-T 312
KY + N+ LT+ D G Y+C A N G+ L V P Q +
Sbjct: 6410 KYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGA 6469
Query: 313 YENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKL 372
+ V L C+ G P E+ W + ++ + ++ +H +SLHI +++
Sbjct: 6470 LKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK-------KFKITSKHFDTSLHILNLEA 6522
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASI 432
SD G Y C+A + +G S + + P+F+ + + G+ + + V+ P S+
Sbjct: 6523 SDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISV 6582
Query: 433 HWRRDK--LVLPAKNT-----TNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRF 485
W +D+ ++ ++NT N+ T G +P + N G+Y C N G R
Sbjct: 6583 VWLKDRGEVIRESENTRISFIDNIATLQLG-------SPEASNS-GKYICQIKNDAGMRE 6634
Query: 486 QEYILALAD 494
+L + +
Sbjct: 6635 CSAVLTVLE 6643
Score = 133 bits (334), Expect = 8e-31
Identities = 146/583 (25%), Positives = 230/583 (39%), Gaps = 36/583 (6%)
Query: 27 LSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
L VE +GE C G PE I WY + K+ S +Q + + L I +
Sbjct: 7026 LEHVEAVIGEPATLQCKVDGTPEIRISWYK-EHTKLRSAPAYKMQFKNNVASLVINKVDH 7084
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLT--FREVVSPQEFKQGEDAEVVCRVSSSPA 143
D G Y C+A ++ G + V++ +KL F + G CR++ S
Sbjct: 7085 SDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEP 7144
Query: 144 PAVSWLYHNEEVTTISDNRFAMLANN--NLQILNINKSDEGIYRCEGRVEARGEIDFRDI 201
VSW Y + + N +N LQIL ++S G Y C +
Sbjct: 7145 LQVSW-YKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL 7203
Query: 202 IVIVN-VPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEE--NEKYI 258
I+ + VPP + K + GE TF C +G+ I+W ++ + I N K
Sbjct: 7204 ILSEHEVPPFFDL--KPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMT 7261
Query: 259 LKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ-LKNETTYENGQ 317
L + LTV + D G Y C A+N AG+D A L V P I+ L+ + +
Sbjct: 7262 LVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDE 7321
Query: 318 VTLV-CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSG 376
T C G P ++ W + E + + + + L + ++ + DSG
Sbjct: 7322 FTRYECKIGGSPEIKVLWYK-------DETEIQESSKFRMSFVDSVAVLEMHNLSVEDSG 7374
Query: 377 RYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRR 436
Y CEA + G S L ++ P F + +G +++ C+++ PP + W +
Sbjct: 7375 DYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYK 7434
Query: 437 DKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
DK L ++ K S + I D G Y C ATN +G+ +AL P
Sbjct: 7435 DKREL--RSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPP 7492
Query: 497 SSPYGVKIIELSQTTAKVSFNKPDSHGGVPIH-HYQVDVKEVASE---IWKIVRSHGVQT 552
+ K+ ++S K + G PI + D E+ E IW I S + T
Sbjct: 7493 R--FVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIW-ISYSENIAT 7549
Query: 553 MVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPS 595
+ + +EP + N G E F TL V EP+
Sbjct: 7550 L-QFSRVEPANAGKYTCQIKNDAGMQ-----ECFATLSVLEPA 7586
Score = 129 bits (325), Expect = 9e-30
Identities = 143/656 (21%), Positives = 258/656 (39%), Gaps = 39/656 (5%)
Query: 47 EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEAT 106
+P + W + E I ++ + + + L A +AG Y CQ + G +E
Sbjct: 5637 QPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKN-DGGMRENM 5695
Query: 107 VVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAML 166
L + + E P GE + C+V+ +P +V W + +T+ ++F+
Sbjct: 5696 ATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFY 5755
Query: 167 AN-NNLQILNINKSDEGIYRCE-----GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNA 220
++L+IL++ + D G Y + G+ +D D VPP+ + K N
Sbjct: 5756 NKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRA----VPPSFTRRLK--NT 5809
Query: 221 TAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVR--NIINSDGGP 278
G C+ +GS +++WF I KY S+ T++ ++ +SD G
Sbjct: 5810 GGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGN 5869
Query: 279 YVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRA 337
Y C A N AG DE +A L V P ++ G+ VT G P ++ W R
Sbjct: 5870 YTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRG 5929
Query: 338 VDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI 397
+GD R + + + L + ++ +S SG Y C ++ G + L +
Sbjct: 5930 AR--ELVKGD-----RCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFV 5982
Query: 398 EYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRK 457
+ F+ + + G I + P S+ W++D + N+ T T +
Sbjct: 5983 KEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVT--TEKT 6040
Query: 458 MILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFN 517
ILEI ++ D G+Y+C N G ++ AL PY V +E + S +
Sbjct: 6041 CILEILNSTKRDAGQYSCEIENEAG---RDVCGALVSTLEPPYFVTELEPLEAAVGDSVS 6097
Query: 518 KPDSHGGVP---IHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNG 574
G P + Y+ D K + ++ ++ V T+ V N + N + E A N
Sbjct: 6098 LQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATL-VFNKVNINDSGEYTCKAENS 6156
Query: 575 KGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGK---SFKLSITKQDDGGAPILEYIVKYR 631
G + Q PPS Q + +++T + +G API +
Sbjct: 6157 IGTASSKTVFRIQ----ERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDG 6212
Query: 632 SKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPK 687
++D+ L+ N + + + + +A+N LG + + + PK
Sbjct: 6213 VLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPK 6268
Score = 128 bits (322), Expect = 2e-29
Identities = 114/494 (23%), Positives = 209/494 (42%), Gaps = 36/494 (7%)
Query: 32 LSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGI 90
++VGE+ C G PE S++WY G+ + S+Q+ S L I + +DAG
Sbjct: 5715 VTVGETCTLECKVAGTPELSVEWYK-DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGT 5773
Query: 91 YRCQATDAKGQTQEATVVLEIYQKL---TFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
Y Q + G++ T V+++ + +F + G + C+V+ S +V+
Sbjct: 5774 YTFQVQNNVGKSS-CTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVA 5832
Query: 148 WLYHNEEV-------TTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRD 200
W + ++ TT SDN LQ+ +++ SD G Y C G + R
Sbjct: 5833 WFHEKTKIVSGAKYQTTFSDNVCT------LQLNSLDSSDMGNYTCVA-ANVAGSDECRA 5885
Query: 201 IIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK 260
++ + P + P+ G+ +TF+ G+P ++WFR + + + ++ +
Sbjct: 5886 VLTVQEPPSFVKEPEP---LEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIY 5942
Query: 261 GSNT--ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQV 318
+T EL + NI S G Y C +N AG+ L V ++ ++ + E G+
Sbjct: 5943 FEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKS 6002
Query: 319 TLVCDAEGEPIP-EITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGR 377
++ +P +TWK+ DGF T +K + + L I + D+G+
Sbjct: 6003 IILESTYTGTLPISVTWKK--DGFNITTSEKC-----NIVTTEKTCILEILNSTKRDAGQ 6055
Query: 378 YDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD 437
Y CE + G + P F++ + G+ +++ C V P ++ W +
Sbjct: 6056 YSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKG 6115
Query: 438 KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPS 497
L + T +TY T L + ND G Y C A N IGT + + + +
Sbjct: 6116 DTKL--RPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQL 6173
Query: 498 SP-YGVKIIELSQT 510
P + ++ ++ QT
Sbjct: 6174 PPSFARQLKDIEQT 6187
Score = 121 bits (304), Expect = 2e-27
Identities = 123/543 (22%), Positives = 214/543 (39%), Gaps = 34/543 (6%)
Query: 47 EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEAT 106
+P S+ W +GE I ++ + + L + + ++G Y CQ + G +E +
Sbjct: 6578 QPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGM-RECS 6636
Query: 107 VVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAML 166
VL + + E P G + C V+ +P + W E++ S + +
Sbjct: 6637 AVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFI 6696
Query: 167 AN-NNLQILNINKSDEGIYRCE-----GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNA 220
+L+I SD+G+Y E G+ + D IV PP+ K NA
Sbjct: 6697 NKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIV----PPSFIRKLKDVNA 6752
Query: 221 TAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNII--NSDGGP 278
G + CR SGS ++ WF++G I K S T+ + SD G
Sbjct: 6753 IL--GASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGI 6810
Query: 279 YVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRA 337
Y C A N AG DE A L V P Q + G +T G P ++ W
Sbjct: 6811 YTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKW--- 6867
Query: 338 VDGFTFTEGDKSLDGR-IEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLD 396
F + + G + + + L + +V+ +SG Y C + G + +L
Sbjct: 6868 -----FKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLF 6922
Query: 397 IEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGR 456
++ F+ + G+PI + PP S+ W +D+ ++ ++ T +
Sbjct: 6923 VKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSIT--MTEK 6980
Query: 457 KMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSF 516
ILEI ++ D+ +Y+C N G Q+ AL V PY ++ +E +
Sbjct: 6981 STILEILESTIEDYAQYSCLIENEAG---QDICEALVSVLEPPYFIEPLEHVEAVIGEPA 7037
Query: 517 N---KPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVN 573
K D + I Y+ K ++ +K+ + V ++V+ N ++ + E A N
Sbjct: 7038 TLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVI-NKVDHSDVGEYSCKADN 7096
Query: 574 GKG 576
G
Sbjct: 7097 SVG 7099
Score = 121 bits (303), Expect = 3e-27
Identities = 134/592 (22%), Positives = 236/592 (39%), Gaps = 23/592 (3%)
Query: 27 LSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIE 86
L V+ ++ + C + + ++ G+K+ + + E + L I A ++
Sbjct: 3650 LEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLK 3709
Query: 87 DAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK-QGEDAEVVCRVSSSPAPA 145
D+G Y C A++ G + + + + + +F + V P GE A + C++ SP
Sbjct: 3710 DSGTYVCTASNEAGSSS-CSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQ 3768
Query: 146 VSWLYHNEEVTTISDNRFAMLANNN-LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVI 204
V+W +N+E++ + R + + L I ++ D G Y CE V G IVI
Sbjct: 3769 VTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEA-VNDVGSDSCSTEIVI 3827
Query: 205 VNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYIL--KGS 262
P I + A RG C SG+ ISWF++ K I ++KY L + S
Sbjct: 3828 KEPPSFIKTLEP---ADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKS 3884
Query: 263 NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLV 321
L + + ++D G Y C N+ G+ A + P ++ ++ GQ VTL
Sbjct: 3885 LVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQ 3944
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 381
G +TW + + DG+I++ +G + L I DV++S G+Y C
Sbjct: 3945 AAVRGSEPISVTWMKGQEVIRE-------DGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997
Query: 382 AASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVL 441
A + G L ++ K I + G+P + V P W +D L
Sbjct: 3998 AENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPL 4057
Query: 442 PAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG 501
A + + + L+ +D G+Y +N +G+ E + D +P+
Sbjct: 4058 VASKKYRISFKNNVAQ--LKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFF 4115
Query: 502 VKIIELSQTTAKVSFNKP-DSHGGVPIH-HYQVDVKEV-ASEIWKIVRSHGVQTMVVLNN 558
K + + + G +P+ + D KE+ AS+ ++I G ++ ++
Sbjct: 4116 TKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEII-R 4174
Query: 559 LEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFK 610
++ N A N G D S I Q P P S P S K
Sbjct: 4175 VDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLK 4226
Score = 119 bits (298), Expect = 1e-26
Identities = 110/477 (23%), Positives = 201/477 (42%), Gaps = 29/477 (6%)
Query: 35 GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G S C G P S+ W++ +G +I S ++ LT+ D+G Y C
Sbjct: 7696 GSSVVMECKVYGSPPISVSWFH-EGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTC 7754
Query: 94 QATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNE 153
AT+ G + E + L + + +F + P + G + V +P +VSW +
Sbjct: 7755 IATNMAG-SDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSS 7813
Query: 154 EVTTISDNRFAMLANN--NLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAI 211
E+ D L ++ L++ +++ S G Y C EA G+ + I PA
Sbjct: 7814 ELVP-GDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEA-GKASCTTHLYIK--APA- 7868
Query: 212 SMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTE--LTVR 269
++ + + E+G+ + +G+P +++W +NG + +++ + + L +
Sbjct: 7869 KFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIP 7928
Query: 270 NIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII-QLKNETTYENGQVTLVCDAEGEP 328
+ D G Y C N +G+D A + + P+ + QL+ +L C G P
Sbjct: 7929 SSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTP 7988
Query: 329 IPEITWKRAVDGFTFTEGDKSLDGRIEVKG--QHGSSSLHIKDVKLSDSGRYDCEAASRI 386
++W + GD L K ++ ++L V ++DSG Y C+A + +
Sbjct: 7989 EIGVSWYK---------GDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSV 8039
Query: 387 GGHQKSMYLDIE---YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPA 443
G S +L ++ P F G P+ C + + P S+ W +D P
Sbjct: 8040 GEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGK--PL 8097
Query: 444 KNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPY 500
K++ N++T L I T + G+Y+CTATN IG+ L L + + P+
Sbjct: 8098 KDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPF 8154
Score = 119 bits (297), Expect = 2e-26
Identities = 126/562 (22%), Positives = 218/562 (38%), Gaps = 43/562 (7%)
Query: 48 PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATV 107
P +I W+ E R V K+ + L ++ A D+G Y CQ ++ G T +
Sbjct: 4796 PMTIKWFKDNKELHSGAARSV-WKDDTSTSLELFAAKATDSGTYICQLSNDVG-TATSKA 4853
Query: 108 VLEIYQKLTFREVVSPQ-EFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAML 166
L + + F + SP + G+ C+++ +P VSW E+T I + + +
Sbjct: 4854 TLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFI 4913
Query: 167 AN-NNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERG 225
QI + G Y CE R +A G I + V PP K +
Sbjct: 4914 DGLATFQISGARVENSGTYVCEARNDA-GTASC-SIELKVKEPPTFIRELKPVEVV--KY 4969
Query: 226 EEMTFSCRASGSPEPAISWFRNGKLIEENEKYIL--KGSNTELTVRNIINSDGGPYVCRA 283
++ C +G+P ++W +N + I ++KY L + S L + SD G Y C
Sbjct: 4970 SDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIV 5029
Query: 284 TNKAGEDEKQAFLQVFVQPHIIQ-LKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFT 342
+N+ G + + P I+ ++N TT T G P ITW + D
Sbjct: 5030 SNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLK--DDQI 5087
Query: 343 FTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPK 402
E D + + ++L I+ V SGRY C+A + G + +L ++ +
Sbjct: 5088 LDEDDN-----VYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQ 5142
Query: 403 FISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD-KLVLPAK--------NTTNLKTYS 453
+ E +P+ + C V P + W +D K ++P++ N + + S
Sbjct: 5143 IVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQS 5202
Query: 454 TGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAK 513
++ + +NDFG +C A Y+ L + K+ ++ +
Sbjct: 5203 VMKQDSGQYTFKVENDFGSSSCDA----------YLRVLDQNIPPSFTKKLTKMDKVLGS 5252
Query: 514 VSFNKPDSHGGVPIH-HYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAV 572
+ G +PI + D KE+++ + H + +NNLE T
Sbjct: 5253 SIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVS 5312
Query: 573 NGKGQGDYSKIEIFQTLPVREP 594
N G S I L V+EP
Sbjct: 5313 NVAGDDACSGI-----LTVKEP 5329
Score = 117 bits (292), Expect = 6e-26
Identities = 97/444 (21%), Positives = 179/444 (40%), Gaps = 25/444 (5%)
Query: 48 PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATV 107
P + WY + ++ S+++ + + + + I N + D G Y C+A + G +
Sbjct: 5545 PFEVVWYKDK-RQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVG-SDTCVC 5602
Query: 108 VLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLA 167
+++ + F ++ GE AE+ + + V WL EEV S+N
Sbjct: 5603 TVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFV 5662
Query: 168 NN--NLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERG 225
N LQ ++ G Y C+ + + + ++V+ PA+ + +K+ T G
Sbjct: 5663 ENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVL---EPAVIV-EKAGPMTVTVG 5718
Query: 226 EEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSN--TELTVRNIINSDGGPYVCRA 283
E T C+ +G+PE ++ W+++GKL+ ++K+ N + L + ++ D G Y +
Sbjct: 5719 ETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQV 5778
Query: 284 TNKAGEDEKQAFLQV---FVQPHII-QLKNETTYENGQVTLVCDAEGEPIPEITWKRAVD 339
N G+ A + V V P +LKN L C G + W
Sbjct: 5779 QNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAW----- 5833
Query: 340 GFTFTEGDKSLDG-RIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
F E K + G + + +L + + SD G Y C AA+ G + L ++
Sbjct: 5834 ---FHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQ 5890
Query: 399 YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKM 458
P F+ G + + ++ PP ++W R L + N+ Y
Sbjct: 5891 EPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNI--YFEDTVA 5948
Query: 459 ILEIAPTSDNDFGRYNCTATNHIG 482
LE+ + G Y C +N+ G
Sbjct: 5949 ELELFNIDISQSGEYTCVVSNNAG 5972
Score = 116 bits (291), Expect = 8e-26
Identities = 100/469 (21%), Positives = 190/469 (40%), Gaps = 24/469 (5%)
Query: 24 TISLSKVELSVGESKFFTCTAIGE-PESIDWYNPQGEKIISTQ-RVVVQKEGVRSRLTIY 81
T L+K++ +G S C G P S W+ E S + R+V + V L +
Sbjct: 5240 TKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVS--LEVN 5297
Query: 82 NANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSS 141
N +ED Y C+ ++ G + +L + + +F Q+ E + +
Sbjct: 5298 NLELEDTANYTCKVSNVAGD-DACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGT 5356
Query: 142 PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILN---INKSDEGIYRCEGRVEARGEIDF 198
P + W ++V +S + + + LN ++ S G Y C + D
Sbjct: 5357 PPFKIKWF--KDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGS--DS 5412
Query: 199 RDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYI 258
+++V PP + + + + G+ C+ +GSPE + WFRN + ++KY
Sbjct: 5413 CTTMLLVTEPPKF-VKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYR 5471
Query: 259 LK--GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNET-TYEN 315
+ S + + N+ D G ++C A N AG + V P T +N
Sbjct: 5472 MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKN 5531
Query: 316 GQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDS 375
+V+L C+ G P E+ W + ++ + ++ ++ +S+HI +V SD
Sbjct: 5532 AEVSLECELSGTPPFEVVWYKDKRQLRSSK-------KYKIASKNFHTSIHILNVDTSDI 5584
Query: 376 GRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWR 435
G Y C+A + +G + ++ P+F+S G P + ++ P + W
Sbjct: 5585 GEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWL 5644
Query: 436 RDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
++K + + + N++ L+ A + G+Y C N G R
Sbjct: 5645 KEKEEV-IRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMR 5692
Score = 115 bits (289), Expect = 1e-25
Identities = 105/460 (22%), Positives = 196/460 (42%), Gaps = 49/460 (10%)
Query: 48 PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATV 107
P S+ W G + +QR + + L I ++ +EDAG Y C +A G+ +
Sbjct: 7896 PISVTW-KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQ 7954
Query: 108 VLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLA 167
+L I + F + + P + G+ A + C+++ +P VSW + ++ + + M
Sbjct: 7955 IL-ILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTT--YKMHF 8011
Query: 168 NNNLQILNINK---SDEGIYRCEGRVEARGEIDFRDIIVIVN--VPPAISMPQKSFNATA 222
NN+ L N+ +D G Y C+ + GE+ + + +PP+ S + T
Sbjct: 8012 RNNVATLVFNQVDINDSGEYICKAE-NSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETV 8070
Query: 223 ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSD---GGPY 279
G + F C SGS ++SW+++GK ++++ + T+ NI +D G Y
Sbjct: 8071 --GLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATL-NIFKTDRSLAGQY 8127
Query: 280 VCRATNKAG-----------EDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEP 328
C ATN G E + F + + P + +E C G
Sbjct: 8128 SCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFE-------CHVTGTQ 8180
Query: 329 IPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGG 388
+++W A D G G+ ++ S+ L + V DSG+Y C A + +G
Sbjct: 8181 PIKVSW--AKDSREIRSG-----GKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGK 8233
Query: 389 HQKSMYLDIE---YAPKFIS--NQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPA 443
+ L+I+ P F ++T+ + EGN + V + P ++ W ++ + +
Sbjct: 8234 DSCTAQLNIKERLIPPSFTKRLSETVEET-EGNSFKLEGRVAGSQPITVAWYKNNIEI-- 8290
Query: 444 KNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
+ T+N + ++L++ ND G Y C +N G+
Sbjct: 8291 QPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGS 8330
Score = 114 bits (286), Expect = 3e-25
Identities = 138/676 (20%), Positives = 268/676 (39%), Gaps = 56/676 (8%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTI 80
L++ + L + + F C E W+ + S++ +++QK+ V + L I
Sbjct: 12640 LRIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYT-LRI 12698
Query: 81 YNANIEDAGIYRCQATDAKGQTQEATVVLEIYQK-LTFREVVSPQEFKQGEDAEVVCRVS 139
+A+++D Y T+ +G+ ++ L + ++ L E + E + + C+V+
Sbjct: 12699 RDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVN 12758
Query: 140 SSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKS---DEGIYRCEGRVEARGEI 196
+ W + EEV DNR + + +L I DEG Y + G+
Sbjct: 12759 RLNV-TLKWTKNGEEVPF--DNRVSYRVDKYKHMLTIKDCGFPDEGEY-----IVTAGQD 12810
Query: 197 DFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK 256
++I+ P + + T ++ FSC+ S + + W+RNG+ I+E +K
Sbjct: 12811 KSVAELLIIEAPT--EFVEHLEDQTVTEFDDAVFSCQLSRE-KANVKWYRNGREIKEGKK 12867
Query: 257 YILK--GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQL----KNE 310
Y + GS L +++ D Y C G +++++ ++FV+ +++ ++
Sbjct: 12868 YKFEKDGSIHRLIIKDCRLDDECEYAC------GVEDRKSRARLFVEEIPVEIIRPPQDI 12921
Query: 311 TTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDV 370
V + + + + E+ W R + +GDK ++ + L I D+
Sbjct: 12922 LEAPGADVVFLAELNKDKV-EVQWLR--NNMVVVQGDKH-----QMMSEGKIHRLQICDI 12973
Query: 371 KLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPA 430
K D G Y A + + L++ APK + G P+ + + P A
Sbjct: 12974 KPRDQGEYRFIAKDK----EARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKA 13029
Query: 431 SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
W ++ L K +T + I D GRY N G L
Sbjct: 13030 EAEWFKENEPLSTKTID-----TTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINL 13084
Query: 491 ALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGV 550
+ DVP +++ E +++ +P + GG I Y V+ +++ + W +
Sbjct: 13085 KVIDVPGPVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAE 13144
Query: 551 QTMVVLNNLEP-NTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE----PSPPSIHGQPSS 605
+ L+ Y RV+A N G G+ +E + R P PP ++ +
Sbjct: 13145 SCEFTVTGLQKGGVEYLFRVSARNRVGTGE--PVETDNPVEARSKYDVPGPP-LNVTITD 13201
Query: 606 GKSFKLSIT---KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGY 662
F +S+T + DGGA I Y+++ R K V+ + + Y
Sbjct: 13202 VNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEY 13261
Query: 663 EVQITAANRLGYSEPT 678
++ A NR+G +P+
Sbjct: 13262 SFRVRAQNRIGVGKPS 13277
Score = 113 bits (283), Expect = 6e-25
Identities = 123/518 (23%), Positives = 207/518 (39%), Gaps = 61/518 (11%)
Query: 22 QVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQ-RVVVQKEGVRSRLT 79
QV L V + G+ F G P+ I WY E+++ST + +G L
Sbjct: 3240 QVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKE--EQLLSTGFKCKFLHDGQEYTLL 3297
Query: 80 IYNANIEDAGIYRCQATDAKG-QTQEATVVLEIYQKLTFREVVSPQE------------- 125
+ A EDA +Y C+A + G T A++ +E+ EVVSP +
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV------PEVVSPDQEMPVYPPAIITPL 3351
Query: 126 ----FKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANN-NLQILNINKSD 180
+G+ A CRVS + VSW ++++ R + L+I D
Sbjct: 3352 QDTVTSEGQPARFQCRVSGTDLK-VSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPED 3410
Query: 181 EGIY-----RCEGRVEARGEIDFR--DIIVIVNVPPAISMPQKSFNATAERGEEMT---- 229
EG Y G+V + + + I+ + I M K+ + E +
Sbjct: 3411 EGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALG 3470
Query: 230 ----FSCRASGSPEPAISWFRNGKLIEENEKYILKGSN--TELTVRNIINSDGGPYVCRA 283
F+C +P WF+ G+ I E++K ++ S + L + D G Y C+A
Sbjct: 3471 HLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKA 3530
Query: 284 TNKAGEDEKQAFLQV---FVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDG 340
+N+ G A L V + + + K+ TT+ +C G P+ E W++ DG
Sbjct: 3531 SNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQK--DG 3588
Query: 341 FTFTEGDKSLDGRI-EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEY 399
+ S + RI + + +H L + ++ + D G Y C+A+++ G L I
Sbjct: 3589 AALSP---SPNWRISDAENKH---ILELSNLTIQDRGVYSCKASNKFGADICQAELIIID 3642
Query: 400 APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMI 459
P FI S +++ C V + ++ W +D LP + K +
Sbjct: 3643 KPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGK--DYKICFEDKIAT 3700
Query: 460 LEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPS 497
LEI D G Y CTA+N G+ + + + PS
Sbjct: 3701 LEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPS 3738
Score = 112 bits (280), Expect = 1e-24
Identities = 98/417 (23%), Positives = 175/417 (41%), Gaps = 37/417 (8%)
Query: 12 LLVSSGQALLQVTISLSKVELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRVVVQ 70
L+++ G+ I L+ V+ VGES F C G +P + W E I S + +
Sbjct: 8144 LILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSRE-IRSGGKYQIS 8202
Query: 71 KEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKL---TFREVVSPQ-EF 126
+ LT+ + D+G Y C A + G+ T L I ++L +F + +S E
Sbjct: 8203 YLENSAHLTVLKVDKGDSGQYTCYAVNEVGK-DSCTAQLNIKERLIPPSFTKRLSETVEE 8261
Query: 127 KQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKS---DEGI 183
+G ++ RV+ S V+W +N E+ S+ NN +L + K+ D G+
Sbjct: 8262 TEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITF--KNNTLVLQVRKAGMNDAGL 8319
Query: 184 YRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS 243
Y C+ +A + I++ P + Q T GE + SC GS I
Sbjct: 8320 YTCKVSNDAGSALCTSSIVIKEPKKPPV-FDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQ 8378
Query: 244 WFRNGKLIEENEK--YILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ 301
W + G+ I+ +++ + L +R++ +D G YVC+A+N AG D ++ + + +
Sbjct: 8379 WLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDK 8438
Query: 302 PHIIQLKNET----------------TYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTE 345
P + + E T + G+PIP + W +
Sbjct: 8439 PAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKG------KW 8492
Query: 346 GDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPK 402
+ GR+ + + + L I+D +DSG Y C A + G + ++ L ++ K
Sbjct: 8493 RQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKK 8549
Score = 112 bits (279), Expect = 2e-24
Identities = 109/479 (22%), Positives = 196/479 (40%), Gaps = 31/479 (6%)
Query: 34 VGESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYR 92
+G S C G P S+ W++ + KI+S + L + + + D G Y
Sbjct: 5813 LGASCILECKVAGSSPISVAWFHEK-TKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYT 5871
Query: 93 CQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHN 152
C A + G + E VL + + +F + P E G++ + +P V+W
Sbjct: 5872 CVAANVAG-SDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGA 5930
Query: 153 EEVTTISDNRFAMLANNN---LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPP 209
E+ + +R + + L++ NI+ S G Y C A G+ + + P
Sbjct: 5931 REL--VKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNA-GQASCTTRLFVKE--P 5985
Query: 210 AISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK--YILKGSNTELT 267
A + + S + + E G+ + +G+ +++W ++G I +EK + L
Sbjct: 5986 AAFLKRLS-DHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILE 6044
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII-QLKNETTYENGQVTLVCDAEG 326
+ N D G Y C N+AG D A + P+ + +L+ V+L C G
Sbjct: 6045 ILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAG 6104
Query: 327 EPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQ--HGSSSLHIKDVKLSDSGRYDCEAAS 384
P ++W + GD L E + + ++L V ++DSG Y C+A +
Sbjct: 6105 TPEITVSWYK---------GDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAEN 6155
Query: 385 RIGGHQKSMYLDIE---YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVL 441
IG I+ P F G P+ ++C + + P + W RD ++L
Sbjct: 6156 SIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLL 6215
Query: 442 PAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPY 500
++ NL+T L+I T + G+Y+C+A+N +GT L + SP+
Sbjct: 6216 --RDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPF 6272
Score = 111 bits (278), Expect = 2e-24
Identities = 117/488 (23%), Positives = 197/488 (40%), Gaps = 48/488 (9%)
Query: 27 LSKVELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
L V+ +VG F C G EP S+ WY G+ + + V + L I+ +
Sbjct: 8063 LRDVQETVGLPVVFDCAISGSEPISVSWYK-DGKPLKDSPNVQTSFLDNTATLNIFKTDR 8121
Query: 86 EDAGIYRCQATDAKGQ-TQEATVVLEIYQKLTFREV-VSPQEFKQGEDAEVVCRVSSSPA 143
AG Y C AT+ G + A ++L + F ++ ++P + GE A+ C V+ +
Sbjct: 8122 SLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQP 8181
Query: 144 PAVSWLYHNEEVTTISDNRFAMLANN-NLQILNINKSDEGIYRCE-----GRVEARGEID 197
VSW + E+ + + + L N+ +L +L ++K D G Y C G+ +++
Sbjct: 8182 IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLN 8241
Query: 198 FRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSC--RASGSPEPAISWFRNGKLIE--E 253
++ ++ PP+ + K + T E E +F R +GS ++W++N I+
Sbjct: 8242 IKERLI----PPSFT---KRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTS 8294
Query: 254 NEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGED--EKQAFLQVFVQPHIIQ--LKN 309
N + K + L VR +D G Y C+ +N AG ++ +P + L
Sbjct: 8295 NCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTP 8354
Query: 310 ETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKD 369
T E V L C +G I W +A G D R G++ L ++D
Sbjct: 8355 VTVSEGEYVQLSCHVQGSEPIRIQWLKA--GREIKPSD-----RCSFSFASGTAVLELRD 8407
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPK---------------FISNQTIYYSWE 414
V +DSG Y C+A++ G + I+ P F+S E
Sbjct: 8408 VAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVE 8467
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
V +P ++ W + K + + G + LEI T+ D G Y
Sbjct: 8468 KTTATFIAKVGGDPIPNVKWTKGKW-RQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYR 8526
Query: 475 CTATNHIG 482
C A N G
Sbjct: 8527 CVAFNEHG 8534
Score = 110 bits (275), Expect = 5e-24
Identities = 110/485 (22%), Positives = 196/485 (40%), Gaps = 30/485 (6%)
Query: 35 GESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G + F T G P ++ W E I + + E + L + ++ G Y C
Sbjct: 4500 GGTAAFQATLKGSLPITVTWLKDSDE-ITEDDNIRMTFENNVASLYLSGIEVKHDGKYVC 4558
Query: 94 QATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNE 153
QA + G Q + +L + + T E + QG+ A + + S + W +
Sbjct: 4559 QAKNDAG-IQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQ 4617
Query: 154 EVTTISDNRFAMLANNN-LQILNINKSDEGIYRCE-----GRVEARGEIDFRDIIVIVNV 207
E+T S + ++ + L+I++ K D G Y E GR + I+ D+I+
Sbjct: 4618 ELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLII---- 4673
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK--GSNTE 265
PP+ + K ++ +G + C +GS +I WF++ + I +EKY +
Sbjct: 4674 PPSFTKKLKKMDSI--KGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAF 4731
Query: 266 LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQL-KNETTYENGQVTLVCDA 324
L + + +D G Y C ATNKAG ++ L V P+ ++ +++ N +V L
Sbjct: 4732 LEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALV 4791
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRI-EVKGQHGSSSLHIKDVKLSDSGRYDCEAA 383
G I W F + + G V S+SL + K +DSG Y C+ +
Sbjct: 4792 GGTAPMTIKW--------FKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLS 4843
Query: 384 SRIGGHQKSMYLDIEYAPKFISNQT-IYYSWEGNPINISCDVKSNPPASIHWRRDKLVLP 442
+ +G L ++ P+FI + + G C + P + W D +
Sbjct: 4844 NDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEIT 4903
Query: 443 AKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGV 502
A + ++ G +I+ + G Y C A N GT L + + P+ +
Sbjct: 4904 AIQKHGI-SFIDG-LATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIREL 4961
Query: 503 KIIEL 507
K +E+
Sbjct: 4962 KPVEV 4966
Score = 110 bits (274), Expect = 7e-24
Identities = 109/507 (21%), Positives = 203/507 (40%), Gaps = 32/507 (6%)
Query: 24 TISLSKVELSVGESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 82
T L V+ V + C G P + W+ E S + + EG S L I
Sbjct: 4116 TKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTAS-LEIIR 4174
Query: 83 ANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSP 142
++ DAG + C+AT++ G +++++ L + + +F ++ G + S
Sbjct: 4175 VDMNDAGNFTCRATNSVG-SKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGST 4233
Query: 143 APAVSWLYHNEEVTTISDNRFAMLA-NNNLQILNINKSDEGIYRCE-----GRVEARGEI 196
+ W N+E+ + A ++L++ + SD G Y C+ G VE +
Sbjct: 4234 PLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANL 4293
Query: 197 DFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK 256
++ PA + + + ++G+ +C+ +G+P I+WF N + I+E+ K
Sbjct: 4294 FVKE--------PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSK 4345
Query: 257 YILK--GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII-QLKNETTY 313
+ + S L + ++ D G Y+C A N+AG D + + V P+ + K
Sbjct: 4346 HRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVL 4405
Query: 314 ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS 373
+ V L+ + G P EITW + D G K + Q SL I +
Sbjct: 4406 KEYDVMLLAEVAGTPPFEITWFK--DNTILRSGRK-----YKTFIQDHLVSLQILKFVAA 4458
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIH 433
D+G Y C + +G S + + P FI S G +K + P ++
Sbjct: 4459 DAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVT 4518
Query: 434 WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILAL- 492
W +D + + N++ L ++ G+Y C A N G + +L++
Sbjct: 4519 WLKDSDEITEDD--NIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVK 4576
Query: 493 --ADVPSSPYGVKIIELSQTTAKVSFN 517
A + + + + T +V F+
Sbjct: 4577 EPATITEEAVSIDVTQGDPATLQVKFS 4603
Score = 109 bits (273), Expect = 9e-24
Identities = 109/487 (22%), Positives = 198/487 (40%), Gaps = 29/487 (5%)
Query: 27 LSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
L V++SVG+S C G PE + WY K+ T + + L +I
Sbjct: 7967 LEPVKVSVGDSASLQCQLAGTPEIGVSWYKGD-TKLRPTTTYKMHFRNNVATLVFNQVDI 8025
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKL--TFREVVSPQEFKQGEDAEVVCRVSSSPA 143
D+G Y C+A ++ G+ +T + QKL +F + + G C +S S
Sbjct: 8026 NDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEP 8085
Query: 144 PAVSWLYHNEEVTTISDNRFAMLANN-NLQILNINKSDEGIYRCEGRVE-ARGEIDFRDI 201
+VSW + + + + + L N L I ++S G Y C R I
Sbjct: 8086 ISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLI 8145
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK- 260
+ PP + +A GE F C +G+ +SW ++ + I KY +
Sbjct: 8146 LTEGKNPPFFDIRLAPVDAVV--GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISY 8203
Query: 261 -GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV---FVQPHIIQLKNETTYENG 316
++ LTV + D G Y C A N+ G+D A L + + P + +ET E
Sbjct: 8204 LENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETE 8263
Query: 317 QVTLVCD---AEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS 373
+ + A +PI +K ++ E+ ++ + L ++ ++
Sbjct: 8264 GNSFKLEGRVAGSQPITVAWYKNNIE--------IQPTSNCEITFKNNTLVLQVRKAGMN 8315
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYA---PKFISNQTIYYSWEGNPINISCDVKSNPPA 430
D+G Y C+ ++ G + + I+ P F + T EG + +SC V+ + P
Sbjct: 8316 DAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPI 8375
Query: 431 SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
I W + + + + ++++G +LE+ + D G Y C A+N G+ + +
Sbjct: 8376 RIQWLKAGREIKPSDRCSF-SFASGTA-VLELRDVAKADSGDYVCKASNVAGSDTTKSKV 8433
Query: 491 ALADVPS 497
+ D P+
Sbjct: 8434 TIKDKPA 8440
Score = 108 bits (271), Expect = 2e-23
Identities = 134/574 (23%), Positives = 222/574 (38%), Gaps = 52/574 (9%)
Query: 27 LSKVELSVGESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
LS + G+S T G P S+ W G I ++++ + L I N+
Sbjct: 5992 LSDHSVEPGKSIILESTYTGTLPISVTW-KKDGFNITTSEKCNIVTTEKTCILEILNSTK 6050
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPA 145
DAG Y C+ + G+ +V + + F + P E G+ + C+V+ +P
Sbjct: 6051 RDAGQYSCEIENEAGRDVCGALVSTL-EPPYFVTELEPLEAAVGDSVSLQCQVAGTPEIT 6109
Query: 146 VSWLYHNEEVTTISDNRFAMLANNNLQILN-INKSDEGIYRCEGRVEARGEIDFRDIIVI 204
VSW + ++ + R N + N +N +D G Y C+ + G + + I
Sbjct: 6110 VSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAE-NSIGTASSKTVFRI 6168
Query: 205 V--NVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGS 262
+PP+ + K T G +T +CR +GS + W+R+G L+ ++E
Sbjct: 6169 QERQLPPSFARQLKDIEQTV--GLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFV 6226
Query: 263 NTELTVRNIINSD---GGPYVCRATNKAG-----------EDEKQAFLQVFVQPHIIQLK 308
+ T++ I+ +D G Y C A+N G E +K F ++P I +
Sbjct: 6227 DNVATLK-ILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFD--IKPVSIDV- 6282
Query: 309 NETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIK 368
C G ITW + D G G + + L I
Sbjct: 6283 ----IAGESADFECHVTGAQPMRITWSK--DNKEIRPG-----GNYTITCVGNTPHLRIL 6331
Query: 369 DVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISN-QTIYYSWEGNPINISCDVKSN 427
V DSG+Y C+A + +G S L ++ PKF+ + + +G I + C + +
Sbjct: 6332 KVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGS 6391
Query: 428 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
P + W R+ L N+ ++ +L I S D G Y C A N +G
Sbjct: 6392 PEIKVSWFRNDSELHESWKYNMSFINS--VALLTINEASAEDSGDYICEAHNGVGDASCS 6449
Query: 488 YILALADVP---SSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQV-DVKEVA-SEIW 542
L + P P V ++ S + + G P V D K+V S+ +
Sbjct: 6450 TALTVKAPPVFTQKPSPVGALKGSDVILQCEIS-----GTPPFEVVWVKDRKQVRNSKKF 6504
Query: 543 KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKG 576
KI H T + + NLE + E A N G
Sbjct: 6505 KITSKH-FDTSLHILNLEASDVGEYHCKATNEVG 6537
Score = 108 bits (270), Expect = 2e-23
Identities = 112/457 (24%), Positives = 189/457 (41%), Gaps = 47/457 (10%)
Query: 27 LSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIE 86
L V ++ GE+ F C E ++WY +G+K+ + +VV + EG LT+ + +E
Sbjct: 12202 LKDVTVTAGETATFDCELSYEDIPVEWYL-KGKKLEPSDKVVPRSEGKVHTLTLRDVKLE 12260
Query: 87 DAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAV 146
DAG + A D K T V E + F + + Q ++G A + C VS A V
Sbjct: 12261 DAGEVQLTAKDFK--THANLFVKE--PPVEFTKPLEDQTVEEGATAVLECEVSRENA-KV 12315
Query: 147 SWLYHNEEVTTISDNRFAMLANNNLQILNIN---KSDEGIYRCEGRVEARGEIDFRDIIV 203
W + E+ + ++ ++A+ ++ L I+ D Y C+ + DF+
Sbjct: 12316 KWFKNGTEI--LKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAK-------DFKTSCN 12366
Query: 204 IVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKY--ILKG 261
+ VPP + + + E F C S + WF++G I++ +KY I KG
Sbjct: 12367 LNVVPPHVEFLRPLTDLQVREKEMARFECELS-RENAKVKWFKDGAEIKKGKKYDIISKG 12425
Query: 262 SNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII--QLKNETTYENGQVT 319
+ L + + D Y C L V + + L N E +
Sbjct: 12426 AVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFTKNLANIEVSETDTIK 12481
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSL--DGRIEVKGQHGSSSLHIKDVKLSDSGR 377
LVC+ +P E+ W + GD+ + GR E+ + L I++ L D+G
Sbjct: 12482 LVCEV-SKPGAEVIWYK---------GDEEIIETGRYEILTEGRKRILVIQNAHLEDAGN 12531
Query: 378 YDCE-AASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRR 436
Y+C +SR G K E A +FIS EG C + S + W+R
Sbjct: 12532 YNCRLPSSRTDGKVKVH----ELAAEFISKPQNLEILEGEKAEFVCSI-SKESFPVQWKR 12586
Query: 437 DKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
D L + + ++ + G+K +L + + D G Y
Sbjct: 12587 DDKTLESGDKYDV--IADGKKRVLVVKDATLQDMGTY 12621
Score = 105 bits (261), Expect = 2e-22
Identities = 121/584 (20%), Positives = 238/584 (40%), Gaps = 48/584 (8%)
Query: 70 QKEGVRSRLTIYNANI-----EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQ 124
+K + R++++N +I D G Y+C ++ G +T V + + +F + +
Sbjct: 4999 KKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVA-LKEPPSFIKKIENT 5057
Query: 125 EFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANN--NLQILNINKSDEG 182
A V+ SP +++WL ++++ DN + ++ LQI +++ G
Sbjct: 5058 TTVLKSSATFQSTVAGSPPISITWL-KDDQILDEDDNVYISFVDSVATLQIRSVDNGHSG 5116
Query: 183 IYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAI 242
Y C+ + E+ E + ++V P I KS + T + + MT C +G+PE +
Sbjct: 5117 RYTCQAKNESGVERCYA--FLLVQEPAQIVEKAKSVDVTEK--DPMTLECVVAGTPELKV 5172
Query: 243 SWFRNGKLIEENEKYILKGSNT--ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV 300
W ++GK I + + + N +++++ D G Y + N G A+L+V
Sbjct: 5173 KWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLD 5232
Query: 301 QPHIIQLKNETTYEN----GQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDK-SLDGRIE 355
Q + T + + + C G W F +G + S +
Sbjct: 5233 QNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQW--------FKDGKEISTSAKYR 5284
Query: 356 VKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEG 415
+ S SL + +++L D+ Y C+ ++ G S L ++ P F+ +
Sbjct: 5285 LVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPD 5344
Query: 416 NPINISCDVKSNPPASIHWRRD--KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
+ + +K PP I W +D +LV K L+ G L + + G+Y
Sbjct: 5345 STVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLE----GSTSFLNLYSVDASKTGQY 5400
Query: 474 NCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSH-GGVP---IHH 529
C TN +G+ +L + + P VK +E S+ ++ + G P +
Sbjct: 5401 TCHVTNDVGSDSCTTMLLVTEPPKF---VKKLEASKIVKAGDSSRLECKIAGSPEIRVVW 5457
Query: 530 YQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTL 589
++ + + AS+ +++ V ++ +NNL + + A N G S I +
Sbjct: 5458 FRNEHELPASDKYRMTFIDSV-AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEP 5516
Query: 590 PVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSK 633
PV PP + ++ S + ++ G P E +V Y+ K
Sbjct: 5517 PVFSSFPPIVETLKNAEVSLECELS-----GTPPFE-VVWYKDK 5554
Score = 99.8 bits (247), Expect = 1e-20
Identities = 149/687 (21%), Positives = 275/687 (40%), Gaps = 71/687 (10%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTI 80
L++ L +E +S F C ++ W GE++ RV + + + LTI
Sbjct: 12734 LRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKW-TKNGEEVPFDNRVSYRVDKYKHMLTI 12792
Query: 81 YNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSS 140
+ D G Y A GQ + +L I F E + Q + +DA C++S
Sbjct: 12793 KDCGFPDEGEYIVTA----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR 12848
Query: 141 SPAPAVSWLYHNEEVTTISDNRFAMLAN-NNLQILNINKSDEGIYRCEGRVEARGEIDFR 199
A V W + E+ +F + + L I + DE Y C VE R R
Sbjct: 12849 EKAN-VKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACG--VEDRKS---R 12902
Query: 200 DIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYIL 259
+ + +P I P + G ++ F + + + W RN ++ + +K+ +
Sbjct: 12903 ARLFVEEIPVEIIRPPQDILEAP--GADVVFLAELN-KDKVEVQWLRNNMVVVQGDKHQM 12959
Query: 260 --KGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ 317
+G L + +I D G Y A +K E +A L++ P I + + G+
Sbjct: 12960 MSEGKIHRLQICDIKPRDQGEYRFIAKDK----EARAKLELAAAPKIKTADQDLVVDVGK 13015
Query: 318 -VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSG 376
+T+V + P E W + + + K++D E +S I + K D G
Sbjct: 13016 PLTMVVPYDAYPKAEAEWFKENEPLS----TKTIDTTAE------QTSFRILEAKKGDKG 13065
Query: 377 RYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRR 436
RY ++ G + + L + P + N + +++G S+ W
Sbjct: 13066 RYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGE-------------VSLAWEE 13112
Query: 437 ------DKLV--LPAKNTTNLKTY--STGRKMILEIAPTSDNDFG---RYNCTATNHIGT 483
K++ + + KT+ +T R E T G + +A N +GT
Sbjct: 13113 PLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGT 13172
Query: 484 ----RFQEYILALA--DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEV 537
+ A + DVP P V I ++++ +++ P+ GG I +Y +++++
Sbjct: 13173 GEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDK 13232
Query: 538 ASEIWKIVRSHGVQTM-VVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTL--PVREP 594
S W + + + + ++ Y RV A N G G S F + P+ P
Sbjct: 13233 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 13292
Query: 595 SPP-SIHGQPSSGKSFKLSITKQ-DDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHII 652
SPP ++ + S +L DGG+PIL YI++ R ++ +D W+ ++ +
Sbjct: 13293 SPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIE-RCEEGKDNWIRCNMKLVPELTY 13351
Query: 653 -LEHLQWTMGYEVQITAANRLGYSEPT 678
+ L+ Y +++A N+ G S+P+
Sbjct: 13352 KVTGLEKGNKYLYRVSAENKAGVSDPS 13378
Score = 99.0 bits (245), Expect = 2e-20
Identities = 103/468 (22%), Positives = 191/468 (40%), Gaps = 29/468 (6%)
Query: 26 SLSKVELSVGESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNAN 84
+L ++ G + C G P I W+ + ++I S+++ + + L I++ N
Sbjct: 3836 TLEPADIVRGTNALLQCEVSGTGPFEISWFKDK-KQIRSSKKYRLFSQKSLVCLEIFSFN 3894
Query: 85 IEDAGIYRCQATDAKGQTQ-EATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPA 143
D G Y C + G+ AT +L+ + TF + V G+ + V S
Sbjct: 3895 SADVGEYECVVANEVGKCGCMATHLLK--EPPTFVKKVDDLIALGGQTVTLQAAVRGSEP 3952
Query: 144 PAVSWLYHNEEVTTISDNRFAMLANNNLQIL---NINKSDEGIYRCEGRVEARGEIDFRD 200
+V+W+ E + D + M +N + +L ++ S G Y C EA + +
Sbjct: 3953 ISVTWMKGQEVIR--EDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGE 4010
Query: 201 IIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK 260
+IV P I + TA G+ T +G+PE W+++G+ + ++KY +
Sbjct: 4011 LIV--KEPAKIIERAELIQVTA--GDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRIS 4066
Query: 261 GSNT--ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVF---VQPHIIQ-LKNETTYE 314
N +L + D G Y +N+ G + V + P + L+N +
Sbjct: 4067 FKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVV 4126
Query: 315 NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSD 374
NG L C G ++W + DG D R + G++SL I V ++D
Sbjct: 4127 NGTCRLDCKIAGSLPMRVSWFK--DGKEIAASD-----RYRIAFVEGTASLEIIRVDMND 4179
Query: 375 SGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHW 434
+G + C A + +G S L ++ P F++ G+ + + + + P +I W
Sbjct: 4180 AGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRW 4239
Query: 435 RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
+ L + + + + + L + TSD+ G Y C +N G
Sbjct: 4240 FKGNKELVSGGSCYITKEALESSLELYLVKTSDS--GTYTCKVSNVAG 4285
Score = 98.2 bits (243), Expect = 3e-20
Identities = 80/297 (26%), Positives = 127/297 (42%), Gaps = 26/297 (8%)
Query: 396 DIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTG 455
D+ P Y G + I V P +I W +D P K TT + T
Sbjct: 24307 DLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGE--PLKQTTRVNVEETA 24364
Query: 456 RKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKV 514
+L I + +DFG+Y TATN GT + + + + P P G V+ E+S +
Sbjct: 24365 TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 24424
Query: 515 SFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVN- 573
S+ P GG I +Y V+ ++ + W +V + +T + + L+ T Y+ R+ A N
Sbjct: 24425 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENR 24484
Query: 574 -GKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQ----------DDGGAP 622
GK SK I Q P +EP PP G F SI+K +DGG
Sbjct: 24485 YGKSAPLDSKAVIVQ-YPFKEPGPP--------GTPFVTSISKDQMLVQWHEPVNDGGTK 24535
Query: 623 ILEYIVKYRSKDKEDQWLE-KKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
I+ Y ++ + K+ W++ K L + YE +++A N +G +P+
Sbjct: 24536 IIGYHLEQKEKN-SILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPS 24591
Score = 97.1 bits (240), Expect = 6e-20
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 7/260 (2%)
Query: 418 INISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTA 477
+ I K P A+++WR+D L K TT + S+ L I S D G Y
Sbjct: 25412 LKIDVPFKGRPQATVNWRKDGQTL--KETTRVNVSSSKTVTSLSIKEASKEDVGTYELCV 25469
Query: 478 TNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEV 537
+N G+ + + D P P ++I E+S + +S+N P+ GG I +Y V+ KE
Sbjct: 25470 SNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKET 25529
Query: 538 ASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE-IFQTLPVREPSP 596
S W IV +T + + L + Y+ RV A N G+ YS+ + P P P
Sbjct: 25530 TSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGP 25589
Query: 597 PSIHGQPSSGKSFKLSITKQ---DDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIIL 653
P + KS L +T Q +DGG+ ++ Y ++Y+ + K+ + +
Sbjct: 25590 PGTPKVVHATKSTML-VTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKV 25648
Query: 654 EHLQWTMGYEVQITAANRLG 673
L + YE ++ A N G
Sbjct: 25649 SGLDEGLMYEYRVYAENIAG 25668
Score = 94.4 bits (233), Expect = 4e-19
Identities = 158/699 (22%), Positives = 267/699 (38%), Gaps = 109/699 (15%)
Query: 52 DWYNPQGEKIISTQRVVVQ-KEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLE 110
+W + +++ T+ VV KEG + + NI AGI G+ E T V+E
Sbjct: 16466 EWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNI--AGI---------GEPGEVTDVIE 16514
Query: 111 IYQKLTFREVVSPQEFKQ------GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFA 164
+ +L ++ + G ++ VS P P V+W NE
Sbjct: 16515 MKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNM-NERTLPQEATIET 16573
Query: 165 MLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAER 224
++++ I N +S +G+Y + EA GE I+ +++VP + P + N T E
Sbjct: 16574 TAISSSMVIKNCQRSHQGVYSLLAKNEA-GERKKTIIVDVLDVPGPVGTPFLAHNLTNES 16632
Query: 225 GEEMTFSCRASGSPEPAISWFRNGKLIEENEK---------YILKGSNTELTVRNIINSD 275
+ FS G P ++ +IE+ E Y + N TV+ +I
Sbjct: 16633 CKLTWFSPEDDGG-SPITNY-----VIEKRESDRRAWTPVTYTVTRQNA--TVQGLIQGK 16684
Query: 276 GGPYVCRATNKAGE----DEKQAF-----LQVFVQPHIIQLKNETTYENGQVTLVC---- 322
+ A N G + +A + V +P +++K T VTL
Sbjct: 16685 AYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVT---KNTVTLTWNPPK 16741
Query: 323 -DAEGEPIPEITWKRAV--DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYD 379
D E I + R + + F D L + VKG +K D+ Y
Sbjct: 16742 YDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKG-----------LKEGDTYEYR 16790
Query: 380 CEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE-------GNPINISCDVKSNPPASI 432
A + +G + S ++ T++ + G ++ P +
Sbjct: 16791 VSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKV 16850
Query: 433 HWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILAL 492
W +D+ + + T++KT T + LE +D G+Y N G+R + +
Sbjct: 16851 SWFKDEADVLEDDRTHIKT--TPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNV 16908
Query: 493 ADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQ 551
D P P G V E+++ +S+ P GG I +Y ++ KEV ++W V S +
Sbjct: 16909 VDRPGPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAK 16968
Query: 552 TMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLP-VREPSPPSIHGQP----SSG 606
T ++ L Y R+ A N G D + + R P P QP +
Sbjct: 16969 TTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPD---QPIVTEVTK 17025
Query: 607 KSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHI----------ILEHL 656
S ++ K DGG PI YI+ +K + ++ + KD I +LE
Sbjct: 17026 DSALVTWNKPHDGGKPITNYIL-----EKRETMSKRWARVTKDPIHPYTKFRVPDLLEGC 17080
Query: 657 QWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTL 695
Q YE +++A N +G +P S P KP KD +
Sbjct: 17081 Q----YEFRVSAENEIGIGDP-----SPPSKPVFAKDPI 17110
Score = 94.4 bits (233), Expect = 4e-19
Identities = 79/287 (27%), Positives = 129/287 (44%), Gaps = 20/287 (6%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSD-NDFGRY 473
G PI + V+ P + WR+ + N M + P S +D G+Y
Sbjct: 18621 GCPIRLFAIVRGRPAPKVTWRK----VGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKY 18676
Query: 474 NCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 533
+ T N G + + + D P +K+ ++++T+ VS+ P++ GG + HY V+
Sbjct: 18677 SLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVE 18736
Query: 534 VKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKI--EIFQTLPV 591
+E + W V +T + NL P Y RV AVN G G + + + + P+
Sbjct: 18737 KREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPL 18796
Query: 592 REPSPP-SIHGQPSSGKSFKLS-ITKQDDGGAPILEYIVKYRSKDK-EDQWLEKKVQGNK 648
EP PP + + S L+ + DGGA I YI YR +++ D+W E V K
Sbjct: 18797 SEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV--K 18854
Query: 649 D-HIILEHLQWTMGYEVQITAANRLGYSEPT----VYEFS---MPPK 687
D +++ L+ Y+ ++ A N +G S P VYE +PPK
Sbjct: 18855 DLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPK 18901
Score = 93.6 bits (231), Expect = 7e-19
Identities = 77/311 (24%), Positives = 139/311 (44%), Gaps = 17/311 (5%)
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPP 429
V +++ GR D + + + K + ++ + P F S Y G + I + P
Sbjct: 23204 VAVNEKGRSDPRSLA-VPIVAKDLVIEPDVKPAFSS----YSVQVGQDLKIEVPISGRPK 23258
Query: 430 ASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYI 489
+I W +D L P K TT + + L I T +D G+Y T N +G +
Sbjct: 23259 PTITWTKDGL--PLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIE 23316
Query: 490 LALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSH 548
+ D P P G VK ++S + +S+N P GG I +Y V ++ + +W +V +
Sbjct: 23317 IVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSAT 23376
Query: 549 GVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE-IFQTLPVREPSPPSIHGQPSSGK 607
+T + + L+ T Y+ R+ A N GQ + + I P +EP PP G P +
Sbjct: 23377 VARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPP---GTPFATA 23433
Query: 608 SFKLSITKQ-----DDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGY 662
K S+ Q ++GG+P++ Y ++ + ++ K + ++L+ + Y
Sbjct: 23434 ISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEY 23493
Query: 663 EVQITAANRLG 673
E ++ A N +G
Sbjct: 23494 EFRVYAENIVG 23504
Score = 92.0 bits (227), Expect = 2e-18
Identities = 75/274 (27%), Positives = 134/274 (48%), Gaps = 26/274 (9%)
Query: 409 IYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDN 468
++ +++G P + V S P +++ R D +TT+ ++ST L + + N
Sbjct: 28377 LFIAYQGRPTPTA--VWSKPDSNLSLRADI------HTTD--SFST-----LTVENCNRN 28421
Query: 469 DFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIH 528
D G+Y T N+ G++ + + + D P P + ++++ +A + ++ P GG IH
Sbjct: 28422 DAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIH 28481
Query: 529 HYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGD-YSKIEIFQ 587
HY V+ +E + W+++ + + +N+L Y RV+AVN G G+ Y E
Sbjct: 28482 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPE--P 28539
Query: 588 TLPVREPSPP-SIHGQPSSGKSFKLSITKQD-DGGAPILEYIVKYRSKDKEDQWLEKKVQ 645
+ +P+PP + +S S L+ K D DGG+ I Y+++ R K D W+E
Sbjct: 28540 IVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKG-SDFWVE---A 28595
Query: 646 GNKDHI--ILEHLQWTMGYEVQITAANRLGYSEP 677
G+ + +E L YE ++ A N GYSEP
Sbjct: 28596 GHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEP 28629
Score = 92.0 bits (227), Expect = 2e-18
Identities = 77/291 (26%), Positives = 123/291 (42%), Gaps = 23/291 (7%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G P+ + + PP + W L ++T++ K L I T+ D G Y
Sbjct: 29753 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAK--LTIRETTIRDTGEYT 29810
Query: 475 CTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 533
N GT + + + D P P G +KI E+ T+ +S+ P+ GG P+ Y V+
Sbjct: 29811 LELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVE 29870
Query: 534 VKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQ-TLPVR 592
++ W V ++ L Y RVAA N G G Y + E+ + +R
Sbjct: 29871 QRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 29930
Query: 593 EPSPP---SIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD 649
P PP I G + +DDGG+ + YIV+ R + + D+W V+ NK
Sbjct: 29931 IPGPPETLQIFDVSRDGMTLTW-YPPEDDGGSQVTGYIVE-RKEVRADRW----VRVNKV 29984
Query: 650 HIILEHLQWT-----MGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTL 695
+ + + T + YE ++TA N G +P S P KP + D +
Sbjct: 29985 PVTMTRYRSTGLTEGLEYEHRVTAINARGSGKP-----SRPSKPIVAMDPI 30030
Score = 91.7 bits (226), Expect = 3e-18
Identities = 78/296 (26%), Positives = 126/296 (42%), Gaps = 17/296 (5%)
Query: 407 QTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTS 466
Q + + G+ I + V P ++ W++ +L N +T +T IL I
Sbjct: 21072 QKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATST--ILNINECV 21129
Query: 467 DNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGV 525
+D G Y TA N +G + + D+P P G +K E+S S++ P++ GGV
Sbjct: 21130 RSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGV 21189
Query: 526 PIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQG-DYSKIE 584
PI +Y V++++ S W + + ++T L Y+ RV A N G G +
Sbjct: 21190 PISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSAC 21249
Query: 585 IFQTLPVREPSPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQW 639
I P + P PP G P K S+T DGG+PIL Y V+ + ++
Sbjct: 21250 IVANYPFKVPGPP---GTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQ 21306
Query: 640 LEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTL 695
K + L + YE ++ A N G S+P S P +P + D +
Sbjct: 21307 TVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKP-----SKPSEPMLALDPI 21357
Score = 91.3 bits (225), Expect = 3e-18
Identities = 101/403 (25%), Positives = 172/403 (42%), Gaps = 35/403 (8%)
Query: 306 QLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDK---SLDGRIEVKGQHGS 362
++K+ TT L C G P+P+I W R G + K S DGR +
Sbjct: 30538 EMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRF--GKELIQSRKYKMSSDGR--------T 30587
Query: 363 SSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI---YYSWEGNPIN 419
+L + + D G Y C A + +G + S L ++ P+F + YY G+ +
Sbjct: 30588 HTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLR 30647
Query: 420 ISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTS-DNDFGRYNCTAT 478
+ P ++ W + +L +N+ N+ +T L + G+Y +
Sbjct: 30648 LHVMYIGRPVPAMTWFHGQKLL--QNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLS 30705
Query: 479 NHIGTRFQEYILALADVPSSPYGVKIIE-LSQTTAKVSFNKPDSHGGVPIHHYQV---DV 534
N GT + + D P P G +IE L + +A +S+ P GG I +Y V +
Sbjct: 30706 NVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEA 30765
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP 594
KE A W++V S T + NL N Y RV+A N G D +E+ + ++ P
Sbjct: 30766 KEGAE--WQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISD--PLEVSSVVIIKSP 30821
Query: 595 -SPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNK 648
P G+P+ K S DGGA I Y ++ R K K+++W+ + +
Sbjct: 30822 FEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREK-KQNKWISVTTEEIR 30880
Query: 649 DHII-LEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNI 690
+ + +++L + YE ++ N G SE + + PK ++
Sbjct: 30881 ETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDV 30923
Score = 90.9 bits (224), Expect = 4e-18
Identities = 148/699 (21%), Positives = 273/699 (39%), Gaps = 59/699 (8%)
Query: 30 VELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAG 89
+ + VG++ G PE + +G+ ++ +RV + ++ R L I A D G
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHG 17977
Query: 90 IYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWL 149
Y A ++ G Q + +V + + + + K+ + + + +++
Sbjct: 17978 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFI 18037
Query: 150 YHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYR--CEGRVEARGEIDFRDIIVIVNV 207
+ + A L N+ ++E +R E +V I+ + I+ +N
Sbjct: 18038 VEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAIN- 18096
Query: 208 PPAISMPQKSFNA-TAERGEEMTF-----SCRASGSPEPAISWFRNGKLIEENEKYILKG 261
I P + N A++G+ + GSP + R K ++ E+ + KG
Sbjct: 18097 --PIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWER-VHKG 18153
Query: 262 S--NTELTVRNIINSDGGPYVCRATNKAGEDE----KQAFLQVFVQPHIIQLKNE---TT 312
S T V + + + + N+ GE + ++ ++ +Q ++ LK T
Sbjct: 18154 SIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTV 18213
Query: 313 YENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKL 372
+ L G+P PE+ W + D T R+++ + SS + K
Sbjct: 18214 KAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSP-----RVKIDTRADSSKFSLTKAKR 18268
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS---CDVKSNPP 429
SD G+Y A + G +++ P + N I +++S C V +PP
Sbjct: 18269 SDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKI--------VDVSSDRCTVCWDPP 18320
Query: 430 ASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPT-----SDNDFGRYNCTATNHIGT- 483
+ + K T +ST +L T N++ + A N IGT
Sbjct: 18321 EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEY-IFRVRAENKIGTG 18379
Query: 484 --RFQEYILALA--DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVAS 539
+ ++A D P P ++ ++S+ V +N P+ GG I Y ++ KE S
Sbjct: 18380 PPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHS 18439
Query: 540 EIWKIVRSHGV-QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYS--KIEIFQTLPVREPSP 596
W V + + + + NL P+ Y+ RV A N G G+ S + P+ P P
Sbjct: 18440 TRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGP 18499
Query: 597 PSIHGQPSSGK-SFKLSITKQD-DGGAPILEYIVKYRSK----DKEDQW--LEKKVQGNK 648
P+ + K S L K DGGAPI+ Y+V+ R K ++ W Q +
Sbjct: 18500 PTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVR 18559
Query: 649 DHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPK 687
+ L YE ++ A N++G P + ++ PK
Sbjct: 18560 KEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPK 18598
Score = 90.5 bits (223), Expect = 6e-18
Identities = 111/431 (25%), Positives = 176/431 (40%), Gaps = 55/431 (12%)
Query: 24 TISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNA 83
T +L+ +E+S ++ C + WY E+II T R + EG + L I NA
Sbjct: 12466 TKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGD-EEIIETGRYEILTEGRKRILVIQNA 12524
Query: 84 NIEDAGIYRCQ----ATDAKGQTQEATVVLEIYQKLTFREVVSPQ--EFKQGEDAEVVCR 137
++EDAG Y C+ TD K + E L + PQ E +GE AE VC
Sbjct: 12525 HLEDAGNYNCRLPSSRTDGKVKVHE----------LAAEFISKPQNLEILEGEKAEFVCS 12574
Query: 138 VSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKS---DEGIY-RCEGRVEAR 193
+S P V W ++ T S +++ ++A+ ++L + + D G Y G A
Sbjct: 12575 ISKESFP-VQW--KRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAA 12631
Query: 194 GEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEE 253
+ + + IV +P K + + +E+ F+C + A WFRN + I +
Sbjct: 12632 AHLTVIEKLRIV-------VPLK--DTRVKEQQEVVFNCEVNTEGAKA-KWFRNEEAIFD 12681
Query: 254 NEKYIL--KGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPH---IIQLK 308
+ KYI+ K L +R+ D Y TN GE+ K A + + + LK
Sbjct: 12682 SSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLK 12741
Query: 309 NETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIK 368
+ T E VT C + + W + + F D R+ + L IK
Sbjct: 12742 DIETMEKKSVTFWCKVNRLNV-TLKWTKNGEEVPF-------DNRVSYRVDKYKHMLTIK 12793
Query: 369 DVKLSDSGRYDCEAASRIGGHQKSM--YLDIEYAPKFISNQTIYYSWEGNPINISCDVKS 426
D D G Y A G KS+ L IE +F+ + E + SC + S
Sbjct: 12794 DCGFPDEGEYIVTA-----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQL-S 12847
Query: 427 NPPASIHWRRD 437
A++ W R+
Sbjct: 12848 REKANVKWYRN 12858
Score = 89.7 bits (221), Expect = 1e-17
Identities = 68/245 (27%), Positives = 110/245 (44%), Gaps = 27/245 (11%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLP----AKNTTNLKTYSTGRKMILEIAPTSDNDF 470
G P++I DV P I W +++ V+ A T + + K L I D
Sbjct: 15413 GEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDK 15472
Query: 471 GRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHY 530
G Y TA+N +G+ F+ + + D PS P + + ++ + ++++ P +GG I HY
Sbjct: 15473 GTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHY 15532
Query: 531 QVDVKEVASE--IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE-IFQ 587
+D ++ + + W+ V + V+ + L PN YE RV AVN G D K + +
Sbjct: 15533 VIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVI 15592
Query: 588 TLPVREPSPPSIHGQP-----SSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEK 642
P R P PP G+P + G D+GG+PI Y WLEK
Sbjct: 15593 QDPYRLPGPP---GKPKVLARTKGSMLVSWTPPLDNGGSPITGY------------WLEK 15637
Query: 643 KVQGN 647
+ +G+
Sbjct: 15638 REEGS 15642
Score = 89.4 bits (220), Expect = 1e-17
Identities = 64/246 (26%), Positives = 123/246 (50%), Gaps = 13/246 (5%)
Query: 440 VLPAKNTTNLKTYS----TGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADV 495
VL +K T+L+T + T + L I + ND G+Y T N + ++ + D
Sbjct: 26218 VLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDT 26277
Query: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVV 555
P P + + ++++ +A +S++ P++ GG P+ +Y ++ +E + + W V ++ +
Sbjct: 26278 PGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYK 26337
Query: 556 LNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE-PSPPSIHGQPSSGKSFKLSIT 614
+ NL+ Y RV+ N G G E + + + E PSPP G S K +S+T
Sbjct: 26338 VTNLQEGAIYYFRVSGENEFGVG--IPAETKEGVKITEKPSPPEKLGVTSISKD-SVSLT 26394
Query: 615 ---KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANR 671
+ DGG+ I+ Y+V+ K +++ W++ V + H++ L+ Y ++ A N+
Sbjct: 26395 WLKPEHDGGSRIVHYVVEALEKGQKN-WVKCAVAKSTHHVV-SGLRENSEYFFRVFAENQ 26452
Query: 672 LGYSEP 677
G S+P
Sbjct: 26453 AGLSDP 26458
Score = 89.0 bits (219), Expect = 2e-17
Identities = 69/267 (25%), Positives = 121/267 (45%), Gaps = 10/267 (3%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G+ + +S +K P + W+++ P K + G K LEI + D G Y+
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAPTK--ARIDVTPVGSK--LEIRNAAHEDGGIYS 17288
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
T N G++ + + D P P +++ E+ + + +++ +P GG I +Y V+
Sbjct: 17289 LTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER 17348
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKI--EIFQTLPVR 592
++VAS W + + + +L Y RVAA N G+G + + I P+
Sbjct: 17349 RDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLH 17408
Query: 593 EPSPP-SIHGQPSSGKSFKLSITKQD-DGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDH 650
P PP +H L K D DGG+PI Y+V+Y+ + +D W++ K N +
Sbjct: 17409 PPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQD-WIKFKTVTNLE- 17466
Query: 651 IILEHLQWTMGYEVQITAANRLGYSEP 677
++ LQ Y ++ A N +G P
Sbjct: 17467 CVVTGLQQGKTYRFRVKAENIVGLGLP 17493
Score = 88.6 bits (218), Expect = 2e-17
Identities = 147/661 (22%), Positives = 245/661 (37%), Gaps = 97/661 (14%)
Query: 90 IYRCQATDAKGQTQEATVVLEIYQKLTFRE-VVSPQEFKQGEDA------EVVCRVSSSP 142
+YR A + G + + ++ + F E + FK G + ++ + P
Sbjct: 13363 LYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYP 13422
Query: 143 APAVSWLYHNEEVTTISDNRFAML-ANNNLQILNINKSDEGIY--RCEGRVEA-RGEIDF 198
P +W + ++ + T + L A L I +SD+GIY + E RV+ GEID
Sbjct: 13423 RPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEID- 13481
Query: 199 RDIIVIVNVPPAISMPQK-SFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE-- 255
VNV S P++ F + +T+ P G ++E+ E
Sbjct: 13482 ------VNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPL-----TGYVVEKREVS 13530
Query: 256 -----KYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE 310
K + ++ E TV +++ + A NK G E
Sbjct: 13531 RKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGP-------------------GE 13571
Query: 311 TTYENGQVTLVCDAEGEPIPE-ITWK-RAVDGFTFTEGDKSLDGRIEVKGQ------HGS 362
Y + V + A PE + W+ R + T DG +KG GS
Sbjct: 13572 PAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGS 13631
Query: 363 SSL-----HIKDVKLSDSG-------RYDCEAASRIGGHQKS------MYLDIEYAP--- 401
+ + K+ +G Y +A +R G + S +D + AP
Sbjct: 13632 DKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIF 13691
Query: 402 ---KFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKM 458
K ++ T+ G I + V P I W + ++L K + + +K
Sbjct: 13692 LDVKLLAGLTVK---AGTKIELPATVTGKPEPKITWTKADMIL--KQDKRITIENVPKKS 13746
Query: 459 ILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNK 518
+ I + +D G Y A N G + + D P P I +++ + +++N
Sbjct: 13747 TVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNP 13806
Query: 519 PDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQG 578
P GG I +Y V+ + SE+W + S T L PN Y RVAA N G G
Sbjct: 13807 PRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVG 13866
Query: 579 DYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSIT---KQDDGGAPILEYIVKYRSKDK 635
+ + +P P +PS +++T DDGG+PI Y V+ D
Sbjct: 13867 EPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPD- 13925
Query: 636 EDQWLEKKVQGNKDHII-LEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDT 694
D+W+ KD ++ L Y ++ A N G +P S +P +IKD
Sbjct: 13926 TDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKP-----SKSTEPILIKDP 13980
Query: 695 L 695
+
Sbjct: 13981 I 13981
Score = 88.6 bits (218), Expect = 2e-17
Identities = 105/441 (23%), Positives = 180/441 (40%), Gaps = 37/441 (8%)
Query: 265 ELTVRNIINSDGGPYVCR--ATNKAGEDEKQAFL-----QVFVQPHIIQLKNETTYENG- 316
+ TV +++ +GG Y R A N AG + A + Q P I LK E G
Sbjct: 16075 QFTVEDLV--EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGT 16132
Query: 317 QVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSG 376
V +V +G P P +TW +A + D + + +L I + SD+G
Sbjct: 16133 NVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTG 16192
Query: 377 RYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRR 436
Y A + +G K M L++ P + S + + +S PP +
Sbjct: 16193 LYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWF----PPKDDGGSK 16248
Query: 437 DKLVLPAKNTTNLKTY----STGRKMILEIAPTSDNDFGRYNCTATNHIGT-----RFQE 487
+ K N KT+ S ++ I + + A N G E
Sbjct: 16249 ITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPE 16308
Query: 488 YILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRS 547
L VP +P + +++ + V++ +P+ GG P+ Y +++K+ S+ WK V
Sbjct: 16309 TARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 16368
Query: 548 HGVQTMVV-----LNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTL--PVREPSP--PS 598
++ M + + L + Y+ RV A+N G G S T P+ P P P
Sbjct: 16369 DPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPK 16428
Query: 599 IHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKE--DQWLEKKVQGNKDHIILEHL 656
+ S + S DGG+ + YIV+Y+ + KE ++ +K+V+G K +++ L
Sbjct: 16429 VTDWTKSSADLEWS-PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTK--LVVTGL 16485
Query: 657 QWTMGYEVQITAANRLGYSEP 677
+ Y+ ++ A N G EP
Sbjct: 16486 KEGAFYKFRVRAVNIAGIGEP 16506
Score = 87.4 bits (215), Expect = 5e-17
Identities = 68/272 (25%), Positives = 120/272 (44%), Gaps = 14/272 (5%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G + + P ++ W +D + P K TT + ST +L I D G Y
Sbjct: 22162 GEDLKVDVPFIGRPTPAVTWHKDNV--PLKQTTRVNAESTENNSLLTIKDACREDVGHYV 22219
Query: 475 CTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 533
TN G + + + D P P G VK+ E++ + +S+ P GG I++Y V+
Sbjct: 22220 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 22279
Query: 534 VKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE-IFQTLPVR 592
++ ++ W+IV + +T + L+ Y+ R+AA N G+ Y E P +
Sbjct: 22280 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 22339
Query: 593 EPSPPSIHGQPSSGKSFKLSITKQ-----DDGGAPILEYIVKYRSKDKEDQWLE-KKVQG 646
P PP G P S + S+ Q DGG+ ++ Y ++ R + W++ K
Sbjct: 22340 VPGPP---GTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLE-RKERNSILWVKLNKTPI 22395
Query: 647 NKDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
+ L+ + YE +++A N +G +P+
Sbjct: 22396 PQTKFKTTGLEEGVEYEFRVSAENIVGIGKPS 22427
Score = 86.3 bits (212), Expect = 1e-16
Identities = 149/708 (21%), Positives = 263/708 (37%), Gaps = 55/708 (7%)
Query: 9 LLGLLVSSGQALLQVTISL--SKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQ 65
+LG+ V + +Q ++ L + + GE IG P +I W GE + T
Sbjct: 24298 VLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVK-DGEPLKQTT 24356
Query: 66 RVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQE 125
RV V++ + L I N +D G Y AT++ G E V+ + + V P
Sbjct: 24357 RVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP---GPPVGPVR 24413
Query: 126 FKQGEDAEVVCRVSSSPAPAVS-------WLYHNEEVTTISDNRF-AMLANNNLQILNIN 177
F + VV +S P PA + ++ + TT + + A +A ++I +
Sbjct: 24414 FDEVSADFVV--ISWEP-PAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLK 24470
Query: 178 KSDEGIYR--CEGRVEARGEIDFRDIIVIVNV----PP------AISMPQK--SFNATAE 223
E +R E R +D + +IV PP +IS Q ++
Sbjct: 24471 TGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVN 24530
Query: 224 RGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTEL------TVRNIINSDGG 277
G + +I W + K ++ K+ G + L + NI+
Sbjct: 24531 DGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKP 24590
Query: 278 PYV--CRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWK 335
V C + + V + ++ + Y+ G E + +P+ W
Sbjct: 24591 SKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWM 24650
Query: 336 RAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYL 395
+A +FT L+ V G + + + +G + E + G +
Sbjct: 24651 KA----SFTN---VLETEFTVSGLVEDQRYEFRVIARNAAGNFS-EPSDSSGAITARDEI 24702
Query: 396 DIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTG 455
D A + + G + D++ P + W +D L + ++ ST
Sbjct: 24703 DAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELE-ETAARMEIKSTI 24761
Query: 456 RKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKV 514
+K L + D G+Y +N GT+ + + D P P G +K+ ++ +
Sbjct: 24762 QKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYL 24821
Query: 515 SFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNG 574
++N P GG I HY ++ +E + W V + + L P Y RV AVN
Sbjct: 24822 AWNPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNK 24881
Query: 575 KGQGD-YSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQ--DDGGAPILEYIVKYR 631
G G+ + P + P PPS + K + + DDGG I YI++ R
Sbjct: 24882 YGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKR 24941
Query: 632 SKDKEDQWLEKKVQGNKD-HIILEHLQWTMGYEVQITAANRLGYSEPT 678
K+ +W + + D + + L YE ++ A N G EP+
Sbjct: 24942 DKEGV-RWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPS 24988
Score = 86.3 bits (212), Expect = 1e-16
Identities = 75/273 (27%), Positives = 117/273 (42%), Gaps = 16/273 (5%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G+ + + V P I W + L +L+ TG++ I +D G+Y
Sbjct: 29062 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQY--TGKRATAVIKFCDRSDSGKYT 29119
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
T N GT+ ++ + D P + + ++Q ++++ P GG I HY V+
Sbjct: 29120 LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVER 29179
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE-IFQTLPVRE 593
+E + W IV V+ L N Y RV AVN G G + E I
Sbjct: 29180 RETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTI 29239
Query: 594 PSPPSIHGQPSSGKS-FKLSITK-QDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHI 651
PSPP I + +GK + TK + DGG I Y+V R K K +W + NKD++
Sbjct: 29240 PSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREK-KSLRW----TRVNKDYV 29294
Query: 652 ILE------HLQWTMGYEVQITAANRLGYSEPT 678
+ + L Y+ ++TA N G SEP+
Sbjct: 29295 VYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 29327
Score = 85.9 bits (211), Expect = 1e-16
Identities = 78/310 (25%), Positives = 141/310 (45%), Gaps = 23/310 (7%)
Query: 396 DIEYAPKF---ISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTY 452
DI AP+ ++ +T + G + + K PP ++ WR+D+ L + +++
Sbjct: 27264 DILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIE-- 27321
Query: 453 STGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYI-LALADVPSSPYGVKIIELSQTT 511
+T +L I + ND G+Y T N +G + + + D P++ +++ +S+ T
Sbjct: 27322 NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGT 27381
Query: 512 AKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAA 571
+ ++ P GG PI +Y ++ ++ W +V T L +L T + RV A
Sbjct: 27382 VTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLA 27441
Query: 572 VNGKGQGDYSKIEIFQTLPVREPSPPS----IHGQPSSGKSFKLSITKQD-DGGAPILEY 626
N G G+ + T PV+ P+ + + S+ S LS TK D DGG+ I EY
Sbjct: 27442 ENEIGIGEPCE----TTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEY 27497
Query: 627 IVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEP------TVY 680
+V+ + K E W + + I + L+ E ++ A N G S+P TV
Sbjct: 27498 VVERKGKG-EQTWSHAGISKTCE-IEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVK 27555
Query: 681 EFSMPPKPNI 690
E + P+ ++
Sbjct: 27556 ELIITPEVDL 27565
Score = 84.0 bits (206), Expect = 5e-16
Identities = 65/276 (23%), Positives = 130/276 (47%), Gaps = 20/276 (7%)
Query: 414 EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
EG ++I ++ P ++ W +D + A + +K LE+ + D G Y
Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAH--LEVPKSVRADAGIY 14457
Query: 474 NCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 533
T N +G+ + + +P +K ++++++ K+++ P+ GG PI HY ++
Sbjct: 14458 TITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 14517
Query: 534 VKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE--IFQTLPV 591
+E + V S + + +L PN Y RV AVN G G+Y +++ + P
Sbjct: 14518 RREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPK 14577
Query: 592 REPSPPSIHGQPSSGKSFKLSITKQD---DGGAPILEYIVKYRSKDKEDQWLEKKVQGNK 648
+ P PP + + + + ++IT + DGG+ I+ YI++ +K E++W +
Sbjct: 14578 QPPDPP-VDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKG-EERW-----KRCN 14630
Query: 649 DHII------LEHLQWTMGYEVQITAANRLGYSEPT 678
+H++ + L+ Y+ ++ A N G SEP+
Sbjct: 14631 EHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPS 14666
Score = 83.6 bits (205), Expect = 7e-16
Identities = 70/235 (29%), Positives = 103/235 (43%), Gaps = 15/235 (6%)
Query: 453 STGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTA 512
ST +L I + D G Y TATN GT+ + + + DVP P V+I +S A
Sbjct: 20430 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 20489
Query: 513 KVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAV 572
+++ P GG PI Y ++ +E + +W +V V L Y RV+AV
Sbjct: 20490 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAV 20549
Query: 573 NGKGQGDYSKIEIFQTLPVR---EPSPPSIHGQPSSGKSFKLSITKQ-----DDGGAPIL 624
N G+G E Q+ PV+ PP +P K + T DDGG+ I
Sbjct: 20550 NHYGKG-----EPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEIT 20604
Query: 625 EYIVKYRSKDKEDQWLEK-KVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
Y V+ R K K +W+ K + + LQ YE +++A NR G P+
Sbjct: 20605 GYHVERREK-KSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 20658
Score = 82.8 bits (203), Expect = 1e-15
Identities = 77/293 (26%), Positives = 122/293 (41%), Gaps = 19/293 (6%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G + I+ D+ P I W +D + + + T + ST +L + D G+Y
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEI--ISTDNHTLLTVKDCIRRDTGQYV 25861
Query: 475 CTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 533
T N GTR + D P P G ++I L+ +S+ +P GG I +Y V+
Sbjct: 25862 LTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVE 25921
Query: 534 VKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGD-YSKIEIFQTLPVR 592
+E + W I T + L Y RV VN G G+ + I P
Sbjct: 25922 KRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFT 25981
Query: 593 EPSPP-SIHGQPSSGKSFKLSITK-QDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD- 649
PSPP S+ + +S L ++ + DGG+ I YI++ R K+ +W+ + D
Sbjct: 25982 VPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSL-RWVRVNKKPVYDL 26040
Query: 650 HIILEHLQWTMGYEVQITAANRLGYSEPT-----------VYEFSMPPKPNII 691
+ L+ YE ++ A N G S P+ V+ S P KP I+
Sbjct: 26041 RVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIV 26093
Score = 81.6 bits (200), Expect = 3e-15
Identities = 93/394 (23%), Positives = 156/394 (39%), Gaps = 50/394 (12%)
Query: 219 NATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK--GSNTELTVRNIINSDG 276
+ T + GE SC+ G P P I W+R GK + ++ KY + G LTV D
Sbjct: 30541 DVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE 30600
Query: 277 GPYVCRATNKAGEDE--KQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAE--GEPIPEI 332
G Y C ATN+ GE E + LQ Q H E Y TL G P+P +
Sbjct: 30601 GVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAM 30660
Query: 333 TWKRAVDGFTFTEGDKSLDG--RIEVKGQHGSSSLHIKDV-KLSDSGRYDCEAASRIGGH 389
TW G K L I ++ + L +K+V + + +G+Y + ++ G
Sbjct: 30661 TW---------FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTV 30711
Query: 390 QKSMYLDIEYAP----------KFISNQTIYY---------SWEGNPINISCDVKSNPPA 430
+ ++I+ P + N + SW N + C+ K
Sbjct: 30712 DAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKE---- 30767
Query: 431 SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
W +LV A + T + + ++ N FG ++ + I
Sbjct: 30768 GAEW---QLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFG-----ISDPLEVSSVVIIK 30819
Query: 491 ALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGV 550
+ + P +P I +++ + V++ P S GG I +Y ++ +E W V + +
Sbjct: 30820 SPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEI 30879
Query: 551 -QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
+T+ + NL YE RV N G+ ++S+I
Sbjct: 30880 RETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI 30913
Score = 80.5 bits (197), Expect = 6e-15
Identities = 91/358 (25%), Positives = 140/358 (39%), Gaps = 48/358 (13%)
Query: 264 TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ--------PHIIQ-LKNETTYE 314
T +V+N+I + + N GE E + PH + L+N
Sbjct: 30882 TVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRY 30941
Query: 315 NGQVTLVCDAEGEPIPEITWKRA-----VDGFTFTEGDKSLDGRI-EVKGQHGSSSLHIK 368
TLVC G P P + W R DG + RI E KG G L I
Sbjct: 30942 QSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKY---------RIQEFKG--GYHQLIIA 30990
Query: 369 DVKLSDSGRYDCEAASRIGGHQKSMYLDIE-----YAPKFISNQTIYYSWEGNPINISCD 423
V D+ Y A ++ G + L++E + PK + ++ G ++I
Sbjct: 30991 SVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIP 31050
Query: 424 VKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTS--DNDFGRYNCTATNHI 481
P I W++ + ++ N + + T R + P D G Y A N
Sbjct: 31051 FSGKPDPVITWQKGQDLID--NNGHYQVIVT-RSFTSLVFPNGVERKDAGFYVVCAKNRF 31107
Query: 482 GTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEI 541
G + L +ADVP P GVK+ ++S+ + +++ +P S GG I +Y V+ +E
Sbjct: 31108 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 31167
Query: 542 WKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSI 599
W V +T + NL T+Y+ RV A N G S EPS P+I
Sbjct: 31168 WLRV-GQARETRYTVINLFGKTSYQFRVIAENKFGLSKPS-----------EPSEPTI 31213
Score = 80.1 bits (196), Expect = 8e-15
Identities = 80/297 (26%), Positives = 119/297 (40%), Gaps = 27/297 (9%)
Query: 415 GNPINISCDVKSNPPASIHWRRD--KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGR 472
G + DV PP ++ W +D +L AK + +ST L ++ D G
Sbjct: 21476 GEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN----LVNKDSTRRDSGA 21531
Query: 473 YNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQ 531
Y TATN G + + + D P P G + + E++ +S+ P GG I HY
Sbjct: 21532 YTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYI 21591
Query: 532 VDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPV 591
V +E + W V S T + + L Y RV AVN G G+ +E L V
Sbjct: 21592 VQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGE--PLESEPVLAV 21649
Query: 592 REPSPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQG 646
PP P K S+ DGG+ I+ YIV+ R K + +W++ +
Sbjct: 21650 NPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQ-RWIKCNKKT 21708
Query: 647 NKD-HIILEHLQWTMGYEVQITAANRLGYSEP-----------TVYEFSMPPKPNII 691
D + L YE +I A N G S P TV++ P P ++
Sbjct: 21709 LTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL 21765
Score = 79.0 bits (193), Expect = 2e-14
Identities = 102/414 (24%), Positives = 172/414 (41%), Gaps = 50/414 (12%)
Query: 305 IQLKNETTYENG-QVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS 363
+ +K+ T + G V L G+P+P ++WK+ DG K +G I++ Q
Sbjct: 19299 VAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL----KPAEG-IKMAMQRNLC 19351
Query: 364 SLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP---------KFISNQTIYYSWE 414
+L + V DSG Y A + G ++ L + P K S++ + SWE
Sbjct: 19352 TLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAML-SWE 19410
Query: 415 -----GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDND 469
G + V + +W + +P + +++ G + I ++N
Sbjct: 19411 PPLEDGGSEITNYIVDKRETSRPNWAQVSATVPI-TSCSVEKLIEGHEYQFRIC--AENK 19467
Query: 470 FGRYNCTATNHIGTRFQEYILALADVPSSPYG----VKIIELSQTTAKVSFNKPDSHGGV 525
+G + T A+A P P G I +++ VS+ P GG
Sbjct: 19468 YGVGDPVFTEP----------AIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 19517
Query: 526 PIHHYQVDVKEVASEIW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQG---DYS 581
PI Y ++ +E + W K+ R ++ + L+ T YE RV A+N G G D S
Sbjct: 19518 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 19577
Query: 582 KIEIFQTLPVREPSPPSIHG-QPSSGKSFKLSITKQD-DGGAPILEYIVKYRSKDKEDQW 639
K + P P PP+ ++ S LS K DGG+PI+ Y+V+ + D D W
Sbjct: 19578 KAAYARD-PQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRAD-SDNW 19635
Query: 640 LEKKVQGN--KDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNII 691
+ + N K + L Y+ ++ A N++GYS+P+ PK +I
Sbjct: 19636 VRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILI 19689
Score = 79.0 bits (193), Expect = 2e-14
Identities = 162/739 (21%), Positives = 265/739 (35%), Gaps = 98/739 (13%)
Query: 26 SLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
+ S + VG+ G P+ + G + T R+ V + L+I +
Sbjct: 23235 AFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHK 23294
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPA 145
+D G Y + GQ T +EI +T + P+ + +D S P
Sbjct: 23295 DDGGQYGITVANVVGQK---TASIEI---VTLDKPDPPKGPVKFDDVSAESITLSWNPPL 23348
Query: 146 VSW--------LYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEID 197
+ + + TT+ D A +A L++ + E +R
Sbjct: 23349 YTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFA 23408
Query: 198 FRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCR--ASGSPEPAISWF-----RNGKL 250
++ P P + ATA + M + P I + RN L
Sbjct: 23409 LESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSIL 23468
Query: 251 IEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ--------- 301
+ K I+ +T+ +N+ + A N G + + +V
Sbjct: 23469 WTKVNKTIIH--DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGT 23526
Query: 302 PHIIQLK-NETT-------YENGQVTLVCDAEGEPIPEITWKRA-----------VDGFT 342
P I +K NE T Y+ G + E +P+ W +A V G T
Sbjct: 23527 PEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLT 23586
Query: 343 FTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPK 402
D+ + R+ K G+ S K SDS I + I PK
Sbjct: 23587 ---EDQRYEFRVIAKNAAGAIS------KPSDS-------TGPITAKDEVELPRISMDPK 23630
Query: 403 FISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEI 462
F TI + G + DV P +I W R + +K +T K +L +
Sbjct: 23631 F--RDTIVVN-AGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIK--NTDFKALLIV 23685
Query: 463 APTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDS 521
D G+Y A+N G++ + + D P P G V++ ++ ++++ P
Sbjct: 23686 KDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQ 23745
Query: 522 HGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYS 581
GG I HY V+ +E + W +V S V + + L Y R+ AVN G G
Sbjct: 23746 DGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVG--- 23802
Query: 582 KIEIFQTLPVREPSPPSIHGQPSS---GKSFKLSIT-----KQDDGGAPILEYIVKYRSK 633
E ++ PV +P + G P S K S+T DGG+ I+ YIV+ R +
Sbjct: 23803 --EPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDR 23860
Query: 634 DKEDQWLEKKVQGNKD-HIILEHLQWTMGYEVQITAANRLGYSEP---TVYEFSM----- 684
+W++ + D + + L YE +++A N G EP TVY +
Sbjct: 23861 -SGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFK 23919
Query: 685 --PPKPNIIKDTLFNGLGL 701
PP I DT N + L
Sbjct: 23920 PGPPTNAHIVDTTKNSITL 23938
Score = 78.6 bits (192), Expect = 2e-14
Identities = 73/285 (25%), Positives = 118/285 (41%), Gaps = 27/285 (9%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNT--------TNLKTYSTGRKMILEIAPTS 466
G+ I I +K P W D A L+T +I+ S
Sbjct: 15825 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 15884
Query: 467 DNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526
G+Y+ TA N G + + + DVP P +K+ ++++ + ++S+ PD GG
Sbjct: 15885 HT--GKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDR 15942
Query: 527 IHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIF 586
I Y ++ + + + W V T V+ +L Y RV A N G G +E
Sbjct: 15943 IKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIG--PPVETI 16000
Query: 587 QTLPVREP-SPPSIHGQPSSGKSFKLSI-----TKQDDGGAPILEYIVKYRSKDKEDQWL 640
Q R+P PP + G K ++ ++DGG+P+ YIV+ + D
Sbjct: 16001 QRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKK 16060
Query: 641 EKKVQGNKDHIILEHLQWTM-------GYEVQITAANRLGYSEPT 678
E Q NK + E LQ+T+ YE ++ A N G S+P+
Sbjct: 16061 EAWRQCNKRDV--EELQFTVEDLVEGGEYEFRVKAVNAAGVSKPS 16103
Score = 78.6 bits (192), Expect = 2e-14
Identities = 66/267 (24%), Positives = 113/267 (42%), Gaps = 10/267 (3%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G + + VK PP I W + + L ++ L ST L + D G+Y
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNL--RDRIGLDIKSTDFDTFLRCENVNKYDAGKYI 19765
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
T N G + ++ + D P P V + E+S+ +A V++ P GG PI +Y V
Sbjct: 19766 LTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQK 19825
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP 594
++ + W V + +T + NLE +Y RV A N G GD E + +
Sbjct: 19826 RDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPG--ETRDAVKASQT 19883
Query: 595 SPPSIHGQPSSGKSFKLSI---TKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHI 651
P + + S SI DGG+ I+ Y+V + + +E++W ++ ++
Sbjct: 19884 PGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLT--EENKW-QRVMKSLSLQY 19940
Query: 652 ILEHLQWTMGYEVQITAANRLGYSEPT 678
+ L Y +++A N G P+
Sbjct: 19941 SAKDLTEGKEYTFRVSAENENGEGTPS 19967
Score = 77.0 bits (188), Expect = 7e-14
Identities = 68/270 (25%), Positives = 121/270 (44%), Gaps = 11/270 (4%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G + I V P + W +++ L K+ + T ++I++ A D+ GRY
Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEGELD-KDRVVIDNVGTKSELIIKDALRKDH--GRYV 15175
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
TATN G++F + + DVP +K + ++ ++++ P+ GG I + ++
Sbjct: 15176 ITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIER 15235
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP 594
K+ W+ ++ + L Y+ RV A N G G +EI L V
Sbjct: 15236 KDAKMHTWR-QPIETERSKCDITGLLEGQEYKFRVIAKNKFGCG--PPVEIGPILAVDPL 15292
Query: 595 SPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD 649
PP+ + + + K +IT + +GG+PI YI++ R DK D K
Sbjct: 15293 GPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTT 15352
Query: 650 HIILEHLQWTMGYEVQITAANRLGYSEPTV 679
++E+L YE ++ A N +G SEP++
Sbjct: 15353 SFLVENLDEHQMYEFRVKAVNEIGESEPSL 15382
Score = 77.0 bits (188), Expect = 7e-14
Identities = 109/462 (23%), Positives = 180/462 (38%), Gaps = 67/462 (14%)
Query: 264 TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ----PHIIQLKNETTYENGQVT 319
T V N+ + +A N+ GE E L V +Q P I+L+ + +V
Sbjct: 15352 TSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVK 15411
Query: 320 ------LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDG----RIEVKGQHGSSSLHIKD 369
+ D G P+P+I W + T +K D + EV + L I
Sbjct: 15412 AGEPVHIPADVTGLPMPKIEWSK-----NETVIEKPTDALQITKEEVSRSEAKTELSIPK 15466
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPK--------FISNQTIYYSWEGNPINIS 421
D G Y A++R+G +++++++ P I ++ Y +W+ N
Sbjct: 15467 AVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGG 15526
Query: 422 CDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTG---RKMILEIAPTSDNDFGRYNCTAT 478
++ H+ DK K + +T R I ++ P +F R
Sbjct: 15527 SEI-------THYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEF-RVRAVNK 15578
Query: 479 NHIGTRFQEYILALAD---VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVK 535
I + + + D +P P K++ ++ + VS+ P +GG PI Y ++ +
Sbjct: 15579 YGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKR 15638
Query: 536 EVASEIWKIVRSHGVQTMVVLNNLEPN-------TTYEIRVAAVNGKGQGDYSKIEIFQT 588
E S W V S T V L +E N Y+ R A+N G G S+ +
Sbjct: 15639 EEGSPYWSRV-SRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEV 15697
Query: 589 L--PVREPSPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQWLE 641
P+ P PPS P K SI+ DGG+PI YIV+ + + D W
Sbjct: 15698 AGDPIFPPGPPSC---PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTD-W-- 15751
Query: 642 KKVQGNKDHI-----ILEHLQWTMGYEVQITAANRLGYSEPT 678
K+V I ++ +L+ Y ++ A N G SEP+
Sbjct: 15752 KRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPS 15793
Score = 77.0 bits (188), Expect = 7e-14
Identities = 67/270 (24%), Positives = 123/270 (45%), Gaps = 19/270 (7%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G + + +K P + W K+ ++ + S+ ++L+ D+ G+Y
Sbjct: 22957 GGSLRLFVPIKGRPTPEVKW--GKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDS--GKYT 23012
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
T N GT+ + + D PS P +K+ E+++ + +++ P GG I +Y V+
Sbjct: 23013 LTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEK 23072
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE- 593
+E + + V ++ + ++ L+ +Y RV A N G G + + V E
Sbjct: 23073 REATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG--LPAQTADPIKVAEV 23130
Query: 594 PSPP-SIHGQPSSGKSFKLSITK-QDDGGAPILEYIVKYRSKDKEDQWLE----KKVQGN 647
P PP I + S LS TK + DGG+ I++YIV+ ++K E +W E K +Q
Sbjct: 23131 PQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSE-KWSECARVKSLQA- 23188
Query: 648 KDHIILEHLQWTMGYEVQITAANRLGYSEP 677
++ +L Y ++ A N G S+P
Sbjct: 23189 ----VITNLTQGEEYLFRVVAVNEKGRSDP 23214
Score = 75.9 bits (185), Expect = 1e-13
Identities = 111/490 (22%), Positives = 185/490 (37%), Gaps = 56/490 (11%)
Query: 31 ELSVGESK--FFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIED 87
++ V E K F C + EP+ ++ W E I T R+ +QKE RL I + + D
Sbjct: 3066 DIKVLEKKRAMFECE-VSEPDITVQWMKDDQELQI-TDRIKIQKEKYVHRLLIPSTRMSD 3123
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
AG Y A G A + +E + + R + + + + A V V+ A
Sbjct: 3124 AGKY---TVVAGGNVSTAKLFVE-GRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDA-H 3178
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINK---SDEGIYRCEGRVEARGEIDFRDIIVI 204
W E+ R + + + I++ SD G Y V R + +
Sbjct: 3179 WYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTF---VAGRNR---SSVTLY 3232
Query: 205 VNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE--KYILKGS 262
VN P + Q+ T + G+ F SG P+P ISW++ +L+ K++ G
Sbjct: 3233 VNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQ 3292
Query: 263 NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVC 322
L + D Y C A N G A L V V + + Y +T +
Sbjct: 3293 EYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQ 3352
Query: 323 D---AEGEPIPEITWKRAVDGFTFTEGDKSLDGRIE------VKGQHGSSSLHIKDVKLS 373
D +EG+P ++ V G S D +I+ + + L I +
Sbjct: 3353 DTVTSEGQP---ARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPE 3409
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE------------------- 414
D G Y A++ +G + L +E AP+ I ++ I E
Sbjct: 3410 DEGTYTFVASNAVGQVSSTANLSLE-APESILHERIEQEIEMEMKAAPVIKRKIEPLEVA 3468
Query: 415 -GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
G+ +C+++S P W + + + +++ S+ LEI T D G Y
Sbjct: 3469 LGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIR--SSKYISSLEILRTQVVDCGEY 3526
Query: 474 NCTATNHIGT 483
C A+N G+
Sbjct: 3527 TCKASNEYGS 3536
Score = 75.9 bits (185), Expect = 1e-13
Identities = 86/394 (21%), Positives = 168/394 (42%), Gaps = 42/394 (10%)
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLD--GRIEVKGQHGSSSLHIKDVKLSDSGR 377
L D G+P+P I W R GDK ++ R E+K + L +KD D G+
Sbjct: 23645 LEADVHGKPLPTIEWLR---------GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQ 23695
Query: 378 YDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS------CDVKSNPPAS 431
Y A++ G KS ++++ + + P+ ++ C + +PP
Sbjct: 23696 YILRASNVAGS--KSFPVNVKVLDRPGPPE--------GPVQVTGVTSEKCSLTWSPPLQ 23745
Query: 432 IHWRR-DKLVLPAKNTTNLKTYSTGRKMI---LEIAPTSDNDFGRYNCTATNH--IGTRF 485
V+ + T+ L +++ L++ + + + A N +G
Sbjct: 23746 DGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPL 23805
Query: 486 QEYILALAD---VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW 542
+ + + + +P P +++ +++ + V +N+PDS GG I Y V+ ++ + W
Sbjct: 23806 ESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRW 23865
Query: 543 -KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTL--PVREPSPPS- 598
K + + + L + YE RV+A N G G+ S ++ PV +P PP+
Sbjct: 23866 IKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTN 23925
Query: 599 IHGQPSSGKSFKLSITKQD-DGGAPILEYIVKYRSKDKEDQWLEKKVQGNK-DHIILEHL 656
H ++ S L+ K DGG+ IL Y+V+ D+E+ + G + + L
Sbjct: 23926 AHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKL 23985
Query: 657 QWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNI 690
Y++++ A N++G E T ++ P+ +
Sbjct: 23986 TEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKL 24019
Score = 75.9 bits (185), Expect = 1e-13
Identities = 64/259 (24%), Positives = 113/259 (43%), Gaps = 15/259 (5%)
Query: 424 VKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
+K P + W + + +L T + T +L I + D GRYN T N+ G+
Sbjct: 25131 IKGRPEPEVKWEKAEGIL----TDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGS 25186
Query: 484 RFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWK 543
+ + + D PS+P + I E+ + + +S+ P GG I +Y V+ +E + +
Sbjct: 25187 KTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYA 25246
Query: 544 IVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQP 603
+ ++ +T + NL+ +Y RV A N G G + T PV+ PP G+
Sbjct: 25247 TITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIG----LPAETTEPVKVSEPPLPPGRV 25302
Query: 604 SSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQW 658
+ + + T + DGG+ I Y+V+ ++K E +W Q + L
Sbjct: 25303 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSE-KW-STCTQVKTLEATISGLTA 25360
Query: 659 TMGYEVQITAANRLGYSEP 677
Y ++ A N G S+P
Sbjct: 25361 GEEYVFRVAAVNEKGRSDP 25379
Score = 75.5 bits (184), Expect = 2e-13
Identities = 144/655 (21%), Positives = 242/655 (36%), Gaps = 88/655 (13%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTI 80
+ +T L + ++ F T E S W G +I ST + ++ + + L I
Sbjct: 2969 IMITSMLKDINAEEKDTITFEVTVNYEGISYKWLK-NGVEIKSTDKCQMRTKKLTHSLNI 3027
Query: 81 YNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSS 140
N + DA Y A A T AT+ +E + + FR+ + + + + A C VS
Sbjct: 3028 RNVHFGDAADYTFVAGKA---TSTATLYVEA-RHIEFRKHIKDIKVLEKKRAMFECEVSE 3083
Query: 141 SPAPAVSWLYHNEEVTT-----ISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
P V W+ ++E+ I ++ + L I + SD G Y V A G
Sbjct: 3084 -PDITVQWMKDDQELQITDRIKIQKEKYV----HRLLIPSTRMSDAGKYT----VVAGGN 3134
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI---- 251
+ + V I +K ++ + F + W+++G I
Sbjct: 3135 VSTAKLFV-EGRDVRIRSIKKEVQVIEKQRAVVEFEVNED---DVDAHWYKDGIEINFQV 3190
Query: 252 EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ--PHIIQLKN 309
+E KY+++ + + SD G Y T AG + L V P ++Q
Sbjct: 3191 QERHKYVVERRIHRMFISETRQSDAGEY----TFVAGRNRSSVTLYVNAPEPPQVLQELQ 3246
Query: 310 ETTYENGQVTLVCDA-EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS--SLH 366
T ++G+ C G P P+I+W + ++ L + K H +L
Sbjct: 3247 PVTVQSGKPARFCAVISGRPQPKISWYKE---------EQLLSTGFKCKFLHDGQEYTLL 3297
Query: 367 IKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE-------------YAPKFISNQTIYYSW 413
+ + D+ Y CEA + G S L +E Y P I+ +
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTS 3357
Query: 414 EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
EG P C V + +DK + P++ + T + LEIA D G Y
Sbjct: 3358 EGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ---LEIAEAYPEDEGTY 3414
Query: 474 NCTATNHIGTRFQEYILALADVPSSPYGVKI---IELSQTTAKVSFNKPDSHGGVPIHHY 530
A+N +G L+L + P S +I IE+ A V K + V + H
Sbjct: 3415 TFVASNAVGQVSSTANLSL-EAPESILHERIEQEIEMEMKAAPVIKRKIEPLE-VALGHL 3472
Query: 531 QVDVKEVAS-------------EIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQ 577
E+ S EI++ + +++ +++LE T + K
Sbjct: 3473 AKFTCEIQSAPNVRFQWFKAGREIYESDKC-SIRSSKYISSLEILRTQVVDCGEYTCKAS 3531
Query: 578 GDYSKIEIFQTLPVREPSPPSIHGQPSS-----GKSFKLSITKQDDGGAPILEYI 627
+Y + TL V E PP+ +P S GK+ K T G P++E I
Sbjct: 3532 NEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVT---GTPVIETI 3583
Score = 75.1 bits (183), Expect = 3e-13
Identities = 67/275 (24%), Positives = 118/275 (42%), Gaps = 21/275 (7%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G + ++ P + W D + ++T + +L I D G Y
Sbjct: 17525 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS--VLTIKNCLRRDTGEYQ 17582
Query: 475 CTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 533
T +N G++ L + DVP P G + I++++ +S+ P GG P+ +Y V+
Sbjct: 17583 ITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVE 17642
Query: 534 VKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE 593
++ + W +V S +T + + +L+ Y RV A N G G ++ T+ +
Sbjct: 17643 KQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVG--PPLDSTPTVAKHK 17700
Query: 594 PSPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNK 648
SPPS G+P + + T + DGG+PI Y ++ R + +W V+ NK
Sbjct: 17701 FSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERR--EVTGKW----VRVNK 17754
Query: 649 DHII-----LEHLQWTMGYEVQITAANRLGYSEPT 678
I + L YE ++ A N G S+P+
Sbjct: 17755 TPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPS 17789
Score = 75.1 bits (183), Expect = 3e-13
Identities = 91/402 (22%), Positives = 156/402 (38%), Gaps = 33/402 (8%)
Query: 312 TYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVK 371
TY+ G E + +PE W +A +FT +D EV G + +
Sbjct: 22463 TYDGGSKITGYIVEKKELPEGRWMKA----SFTN---IIDTHFEVTGLVEDHRYEFRVIA 22515
Query: 372 LSDSGRYD--CEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPP 429
+ +G + E+ I + I PK+ ++ G + D+ P
Sbjct: 22516 RNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVH---AGESFKVDADIYGKPI 22572
Query: 430 ASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYI 489
+I W + L NT L+ ST L + D G Y A N G R
Sbjct: 22573 PTIQWIKGDQEL--SNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 22630
Query: 490 LALADVPSSPYGVKIIE-LSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSH 548
+ + D P P G +I ++ +++ P GG I +Y V+ +E + +W +V ++
Sbjct: 22631 VKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDAN 22690
Query: 549 GVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE-IFQTLPVREPSPPSIHGQPSSGK 607
+ L Y R+ AVN G G+ + E + P P P + K
Sbjct: 22691 VQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTK 22750
Query: 608 SFKLSITKQ--DDGGAPILEYIVKYRSKDKEDQW--LEKKVQGNKDHIILEHLQWTMGYE 663
+ + ++ DGG+ IL Y+++ R K+ +W K++ G + + L YE
Sbjct: 22751 DSMIVVWERPASDGGSEILGYVLEKRDKE-GIRWTRCHKRLIGEL-RLRVTGLIENHDYE 22808
Query: 664 VQITAANRLGYSEPT-----------VYEFSMPPKPNIIKDT 694
+++A N G SEP+ +Y+ P P +I T
Sbjct: 22809 FRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDIT 22850
Score = 74.3 bits (181), Expect = 4e-13
Identities = 124/568 (21%), Positives = 210/568 (36%), Gaps = 76/568 (13%)
Query: 27 LSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIE 86
L VE+ E+ F T I E + + +GE ++ T +++EG L ++N ++
Sbjct: 12113 LHSVEVMETETARFE-TEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLD 12171
Query: 87 DAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAV 146
G QA + K I ++V GE A C +S P V
Sbjct: 12172 QTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVT----VTAGETATFDCELSYEDIP-V 12226
Query: 147 SWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRV----------EARGEI 196
W ++ + SD+ + R EG+V E GE+
Sbjct: 12227 EWYLKGKK---------------------LEPSDKVVPRSEGKVHTLTLRDVKLEDAGEV 12265
Query: 197 -----DFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI 251
DF+ + P + + + T E G C S + WF+NG I
Sbjct: 12266 QLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVS-RENAKVKWFKNGTEI 12324
Query: 252 EENEKY--ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKN 309
+++KY + G +L + + D Y C A +D K + V PH+ L+
Sbjct: 12325 LKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDA-----KDFKTSCNLNVVPPHVEFLRP 12379
Query: 310 ET---TYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLH 366
T E C+ E ++ W + DG +G K ++ + L
Sbjct: 12380 LTDLQVREKEMARFECELSREN-AKVKWFK--DGAEIKKGKK-----YDIISKGAVRILV 12431
Query: 367 IKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKS 426
I L D Y CE + M +E F N E + I + C+V S
Sbjct: 12432 INKCLLDDEAEYSCEVRT---ARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEV-S 12487
Query: 427 NPPASIHW-RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNC-TATNHIGTR 484
P A + W + D+ ++ T + + GRK IL I D G YNC ++ +
Sbjct: 12488 KPGAEVIWYKGDEEII---ETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGK 12544
Query: 485 FQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKI 544
+ + LA A+ S P ++I+E + S +K P+ + D + + + +
Sbjct: 12545 VKVHELA-AEFISKPQNLEILEGEKAEFVCSISKE----SFPVQWKRDDKTLESGDKYDV 12599
Query: 545 VRSHGVQTMVVLN-NLEPNTTYEIRVAA 571
+ + +VV + L+ TY + V A
Sbjct: 12600 IADGKKRVLVVKDATLQDMGTYVVMVGA 12627
Score = 73.9 bits (180), Expect = 6e-13
Identities = 64/285 (22%), Positives = 115/285 (40%), Gaps = 10/285 (3%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G+ I + V+ P + W +DK + +K + + +D G+Y
Sbjct: 18216 GDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 18275
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
TATN G+ + + D P +KI+++S V ++ P+ GG I +Y ++
Sbjct: 18276 VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEK 18335
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVN--GKGQGDYSKIEIFQTLPVR 592
E +W + + + L Y RV A N G G SK I +T +
Sbjct: 18336 CETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDK 18395
Query: 593 --EPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDH 650
P PP + + S + + + DGG I Y ++ + K K +
Sbjct: 18396 PGRPDPPEV-TKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERR 18454
Query: 651 IILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTL 695
+ +++L Y+ ++ A N +G EP S+P +P + KD +
Sbjct: 18455 MKVQNLLPDHEYQFRVKAENEIGIGEP-----SLPSRPVVAKDPI 18494
Score = 73.9 bits (180), Expect = 6e-13
Identities = 66/257 (25%), Positives = 116/257 (45%), Gaps = 11/257 (4%)
Query: 424 VKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
+K P + W RD ++ ST +L + + D G+Y T N G+
Sbjct: 21884 IKGRPAPEVKWARDH----GESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGS 21939
Query: 484 RFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWK 543
+ + + D P P +K+ E+++T+ ++++ P GG I +Y V+ +E + +
Sbjct: 21940 KSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYS 21999
Query: 544 IVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE-PSPP-SIHG 601
V ++ +T ++ L+ +Y RV A N G G E +++ E P PP I
Sbjct: 22000 TVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG--LPAETAESVKASERPLPPGKITL 22057
Query: 602 QPSSGKSFKLSITK-QDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTM 660
+ S LS K + DGG+ IL YIV+ ++K D+W + I +Q
Sbjct: 22058 MDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKG-SDKWATCATVKVTEATITGLIQGE- 22115
Query: 661 GYEVQITAANRLGYSEP 677
Y +++A N G S+P
Sbjct: 22116 EYSFRVSAQNEKGISDP 22132
Score = 73.9 bits (180), Expect = 6e-13
Identities = 64/284 (22%), Positives = 118/284 (41%), Gaps = 13/284 (4%)
Query: 402 KFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILE 461
K + T+Y G+ + + + P + RD + P K T T T + +
Sbjct: 26479 KNFPSHTVYVR-AGSNLKVDIPISGKPLPKVTLSRDGV--PLKATMRFNTEITAENLTIN 26535
Query: 462 IAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPD 520
+ + D GRY TA N GT + + D P P G V I ++++ + + + P
Sbjct: 26536 LKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPK 26595
Query: 521 SHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDY 580
GG + +Y + +E ++ +W V + +TM+ + L Y+ R+ A N G D+
Sbjct: 26596 YDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDH 26655
Query: 581 -SKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKD 634
+ LP P PPS P + SIT +GG+ ++ Y ++ + ++
Sbjct: 26656 IDSACVTVKLPYTTPGPPS---TPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRN 26712
Query: 635 KEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
K+ H + + + YE ++ A N G +P+
Sbjct: 26713 SILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPS 26756
Score = 73.6 bits (179), Expect = 7e-13
Identities = 94/403 (23%), Positives = 167/403 (41%), Gaps = 66/403 (16%)
Query: 326 GEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASR 385
G+P P+++W + E D D R +K + +L K SDSG+Y +
Sbjct: 16844 GKPKPKVSWFK-------DEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENS 16896
Query: 386 IGGHQKSMYLDIEYAP---------KFISNQTIYYSW-----EGNPINISCDVKSNPPAS 431
G + +++ P ++ + SW +G + ++
Sbjct: 16897 TGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGK 16956
Query: 432 IHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILA 491
W AK T + G+ I I ++N +G + ++ + + +
Sbjct: 16957 DVWM-PVTSASAKTTCKVSKLLEGKDYIFRIH--AENLYGISDPLVSDSMKAKDR---FR 17010
Query: 492 LADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQ 551
+ D P P + E+++ +A V++NKP GG PI +Y ++ +E S+ W V +
Sbjct: 17011 VPDAPDQPI---VTEVTKDSALVTWNKPHD-GGKPITNYILEKRETMSKRWARVTKDPIH 17066
Query: 552 --TMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE--IFQTLPVREPSPPSIHGQPSSGK 607
T + +L YE RV+A N G GD S +F P+ +PSPP ++ +
Sbjct: 17067 PYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP-VNPEAIDTT 17125
Query: 608 SFKLSITKQD---DGGAPILEYIVKYRSKDKEDQW------------LEKKVQGNKDHII 652
+ +T Q DGG+ IL YIV+Y+ K +++W + KV G +D
Sbjct: 17126 CNSVDLTWQPPRHDGGSKILGYIVEYQ-KVGDEEWRRANHTPESCPETKYKVTGLRD--- 17181
Query: 653 LEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTL 695
Y+ ++ A N G S+P + P+P ++KD L
Sbjct: 17182 ------GQTYKFRVLAVNAAGESDP-----AHVPEPVLVKDRL 17213
Score = 73.6 bits (179), Expect = 7e-13
Identities = 154/719 (21%), Positives = 268/719 (37%), Gaps = 108/719 (15%)
Query: 21 LQVTISLSK-VELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLT 79
L++ L K V + G S + G P + ++ QG + S R ++ S L
Sbjct: 29446 LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLI 29503
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVS 139
+ N DAG Y +A + G+ + ATV++++Y V +E + + + +
Sbjct: 29504 VDKVNRYDAGKYTIEAENQSGK-KSATVLVKVYDTPGPCPSVKVKEVSR-DSVTITWEIP 29561
Query: 140 S--SPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEAR---- 193
+ AP +++ E AM A + K + +YR G VE
Sbjct: 29562 TIDGGAPVNNYIVEKREA--------AMRAFKTVT----TKCSKTLYRISGLVEGTMYYF 29609
Query: 194 ----------GE-IDFRDIIVIVNVP--PAISMPQKSFNATAERGEEMTFSCRASGSPEP 240
GE + D +++ VP PA +T E S
Sbjct: 29610 RVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGY 29669
Query: 241 AISWFRNGKLIEENEKYI-LKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF---- 295
+ + G E K + LK + E TV ++ + + RA N+ G E +
Sbjct: 29670 VLEACKAGT--ERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 29727
Query: 296 ----LQVFVQPHIIQLKNETTY--ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKS 349
L+V + + +T + V LV G P P +W F G K
Sbjct: 29728 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASW--------FFAGSKL 29779
Query: 350 LDG-RIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP------- 401
+ R+ V+ + L I++ + D+G Y E + G +++ + I P
Sbjct: 29780 RESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPI 29839
Query: 402 --KFISNQTIYYSWE------GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTY- 452
I +I SWE G P++ V+ W LP + T+
Sbjct: 29840 KIDEIDATSITISWEPPELDGGAPLS-GYVVEQRDAHRPGW------LPVSESVTRSTFK 29892
Query: 453 ----STGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALAD---VPSSPYGVKII 505
+ G + + +A T N FG IG+ Q ++ +P P ++I
Sbjct: 29893 FTRLTEGNEYVFRVAAT--NRFG---------IGSYLQSEVIECRSSIRIPGPPETLQIF 29941
Query: 506 ELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGV-QTMVVLNNLEPNTT 564
++S+ +++ P+ GG + Y V+ KEV ++ W V V T L
Sbjct: 29942 DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLE 30001
Query: 565 YEIRVAAVNGKGQGDYSK-----IEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDG 619
YE RV A+N +G G S+ + + P +P P + + S S+ +D+G
Sbjct: 30002 YEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVP-EDEG 30060
Query: 620 GAPILEYIVKYRSKDKEDQWLEKKVQGNK-DHIILEHLQWTMGYEVQITAANRLGYSEP 677
G+ + Y+++ + D + +W + K L HL Y ++ A N G EP
Sbjct: 30061 GSKVTGYLIEMQKVD-QHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEP 30118
Score = 73.2 bits (178), Expect = 1e-12
Identities = 68/287 (23%), Positives = 123/287 (42%), Gaps = 17/287 (5%)
Query: 414 EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
+G I ++ +K P W ++ + + + T T +++++ A D+ G Y
Sbjct: 30150 QGGVIRLTIPIKGKPFPICKWTKEGQDISKR--AMIATSETHTELVIKEADRGDS--GTY 30205
Query: 474 NCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQV 532
+ N G + + + P+SP G ++ ++ + +VS+ P GG I Y +
Sbjct: 30206 DLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYIL 30265
Query: 533 DVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE--IFQTLP 590
+ +EV W + S T +V+ L+ N Y RV+A N G K E + P
Sbjct: 30266 ERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTP 30325
Query: 591 VREPSPPSIHGQPSSGKSFKLSIT---KQDDGGAPILEYIVKYRSKDKEDQWL-EKKVQG 646
+ P PPS + +S++ +DDGG+ + Y ++ R + D+W+ K Q
Sbjct: 30326 LNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIE-RKETSTDKWVRHNKTQI 30384
Query: 647 NKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKD 693
+ L Y+ +I A N +G SE S +P + KD
Sbjct: 30385 TTTMYTVTGLVPDAEYQFRIIAQNDVGLSET-----SPASEPVVCKD 30426
Score = 73.2 bits (178), Expect = 1e-12
Identities = 73/318 (22%), Positives = 131/318 (41%), Gaps = 57/318 (17%)
Query: 127 KQGEDAEVVCRVSS-SPAPAVSWLYHNEEVTTISDNRFAMLANNNLQIL---NINKSDEG 182
++G + VC++ + + V+W + ++ + ++ + + + IL +I K D+G
Sbjct: 31580 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLE--NSEKYEITYEDGVAILYVKDITKLDDG 31637
Query: 183 IYRCE-----GRVEARGEIDFR---------------------DIIVIVNVPPAISMPQK 216
YRC+ G + E+ + D + ++ PP ++P
Sbjct: 31638 TYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPL- 31696
Query: 217 SFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI---EENEKYILKGSN--TELTVRNI 271
+N TA GE + F + PEP ++W+++G+ I + ++KY + +LT+ ++
Sbjct: 31697 -YNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSV 31755
Query: 272 INSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ----------LKNETTYENGQVTLV 321
D Y A NK GED +A L V + P L N E V
Sbjct: 31756 TTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFE 31815
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH-GSSSLHIKDVKLSDSGRYDC 380
G P P + W++ DG SL IE+ + +LHI+D D+G Y
Sbjct: 31816 IRVSGIPPPTLKWEK--DGQPL-----SLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRV 31868
Query: 381 EAASRIGGHQKSMYLDIE 398
A + G +L +E
Sbjct: 31869 TATNTAGSTSCQAHLQVE 31886
Score = 72.4 bits (176), Expect = 2e-12
Identities = 145/710 (20%), Positives = 260/710 (36%), Gaps = 108/710 (15%)
Query: 30 VELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAG 89
V + G G+PE + +++ ++V +Q G R+ I + D+G
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSG 29116
Query: 90 IYRCQATDAKGQTQEATVVLEIYQ------KLTFREVVS---------PQEFKQGEDAEV 134
Y +A G T+ +V++++ KLT V PQE E
Sbjct: 29117 KYTLTVKNASG-TKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHY 29175
Query: 135 VCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNN--LQILNINKSDEGIYRCEGRVEA 192
+ V ++W+ E T+S ++ NN ++ +NK G+ + A
Sbjct: 29176 I--VERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVA 29233
Query: 193 RGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFR------ 246
R + PP I EE+ +G I W +
Sbjct: 29234 RNSFT-------IPSPPGIP-------------EEV-----GTGKEHIIIQWTKPESDGG 29268
Query: 247 ---NGKLIEENEKYILKGS---------NTELTVRNIINSDGGPYVCRATNKAGEDEKQA 294
+ L+++ EK L+ + +T L V +++ + A N AG E
Sbjct: 29269 NEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSE 29328
Query: 295 FLQVFVQPHIIQLKNETTYENGQVTL--VCDAEGEPIPEITWKRAVDGFTFTEG------ 346
+ I + E +Y G + V D I K DG T G
Sbjct: 29329 ------ASNFISCR-EPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQ 29381
Query: 347 DKSLDG--RIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYL--------- 395
+K D R+ ++ + D+K+ + A + G + S +
Sbjct: 29382 EKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERI 29441
Query: 396 ---DIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTY 452
D+E A TI G + + V PP I W + + L ++ +
Sbjct: 29442 EIPDLELADDLKKTVTIR---AGASLRLMVSVSGRPPPVITWSKQGIDLASRAIID---- 29494
Query: 453 STGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTA 512
+T +L + + D G+Y A N G + ++ + D P VK+ E+S+ +
Sbjct: 29495 TTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV 29554
Query: 513 KVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAV 572
+++ P GG P+++Y V+ +E A +K V + +T+ ++ L T Y RV
Sbjct: 29555 TITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPE 29614
Query: 573 NGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQ-DDGGAPILEYIVKYR 631
N G G+ + + P + + + L+ K DGG+ + Y+++
Sbjct: 29615 NIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLE-A 29673
Query: 632 SKDKEDQWLEKKVQGNKDHIILEHLQWTMG----YEVQITAANRLGYSEP 677
K ++W+ KV K +LEH ++ Y +I A N G SEP
Sbjct: 29674 CKAGTERWM--KVVTLKP-TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEP 29720
Score = 71.6 bits (174), Expect = 3e-12
Identities = 88/388 (22%), Positives = 162/388 (41%), Gaps = 52/388 (13%)
Query: 318 VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSL--DGRIEVKGQHGSSSLHIKDVKLSDS 375
V L G+P P I W + DK L + + V+ +S+ IKD +S
Sbjct: 26890 VKLRAGISGKPAPTIEWYK---------DDKELQTNALVCVENTTDLASILIKDADRLNS 26940
Query: 376 GRYDCEAASRIGGHQKSMYLDIEYAP---------KFISNQTIYYSWEGNPINISCDVKS 426
G Y+ + + +G ++ + I P K ++ + I W
Sbjct: 26941 GCYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWR------------ 26988
Query: 427 NPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSD-----NDFGRYNCTATNHI 481
PPA + + K T+ +S + + E T+ N++ + A N
Sbjct: 26989 -PPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEY-IFRVRAVNKY 27046
Query: 482 GT----RFQEYILALADVPSSPYGV-KIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKE 536
G + A V P G+ ++ ++++ + V +++P + GG I Y ++ ++
Sbjct: 27047 GIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRD 27106
Query: 537 VASEIW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTL--PVRE 593
S W K+++ T + L N+ Y+ RV AVN GQG +S+ F P+
Sbjct: 27107 KKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDP 27166
Query: 594 PSPPS-IHGQPSSGKSFKLSITKQD-DGGAPILEYIVKYRSKDKEDQWLEKKVQG--NKD 649
P PP+ I S+ S L +K DGG+ + Y+V+ R + +E++W +G
Sbjct: 27167 PGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIR-QGEEEEWTTVSTKGEVRTT 27225
Query: 650 HIILEHLQWTMGYEVQITAANRLGYSEP 677
++ +L+ + Y +++A N G EP
Sbjct: 27226 EYVVSNLKPGVNYYFRVSAVNCAGQGEP 27253
Score = 71.2 bits (173), Expect = 4e-12
Identities = 110/446 (24%), Positives = 185/446 (41%), Gaps = 54/446 (12%)
Query: 264 TELTVRNIINSDGGPYVCRATNKAG-EDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVC 322
TE T+ +I + + A N+ G D +Q + V + +I + + V
Sbjct: 22104 TEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGE 22163
Query: 323 DAE------GEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSG 376
D + G P P +TW + D + R+ + +S L IKD D G
Sbjct: 22164 DLKVDVPFIGRPTPAVTWHK--DNVPLKQTT-----RVNAESTENNSLLTIKDACREDVG 22216
Query: 377 RYDCEAASRIGGHQKSMYLDIEYAP---------KFISNQTIYYSWE------GNPINIS 421
Y + + G +++ + + P ++ +I SW G+ IN +
Sbjct: 22217 HYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSIN-N 22275
Query: 422 CDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHI 481
V+ ++ W+ + A+ T TG + IA ++N +G+ T N
Sbjct: 22276 YIVEKRDTSTTTWQIVSATV-ARTTIKACRLKTGCEYQFRIA--AENRYGK--STYLNSE 22330
Query: 482 GTRFQEYILALADVPSSPYGVKIIELS-QTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE 540
T Q VP P G ++ LS + + +V +N+P S GG + Y ++ KE S
Sbjct: 22331 PTVAQYPF----KVPGPP-GTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSI 22385
Query: 541 IW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSI 599
+W K+ ++ QT LE YE RV+A N G G SK+ + R+P P
Sbjct: 22386 LWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVS--ECYVARDPCDPP- 22442
Query: 600 HGQPSSGKSFKLSITKQ-----DDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD-HIIL 653
G+P + + S+T Q DGG+ I YIV+ + + E +W++ D H +
Sbjct: 22443 -GRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVE-KKELPEGRWMKASFTNIIDTHFEV 22500
Query: 654 EHLQWTMGYEVQITAANRLG-YSEPT 678
L YE ++ A N G +SEP+
Sbjct: 22501 TGLVEDHRYEFRVIARNAAGVFSEPS 22526
Score = 71.2 bits (173), Expect = 4e-12
Identities = 91/413 (22%), Positives = 169/413 (40%), Gaps = 75/413 (18%)
Query: 314 ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS 373
+ G + L +G+P P W T+ + + R + + L IK+
Sbjct: 30150 QGGVIRLTIPIKGKPFPICKW---------TKEGQDISKRAMIATSETHTELVIKEADRG 30200
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEY--APKFISNQTIYYSWEGNPINISCDVKSNPPAS 431
DSG YD ++ G +K++Y+ + +P Y + + +S PPA
Sbjct: 30201 DSGTYDLVLENKCG--KKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSW----RPPAD 30254
Query: 432 ------IHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT-- 483
+ + ++ +P + + G ++++ +N + +A N G
Sbjct: 30255 DGGADILGYILERREVPKAAWYTIDSRVRGTSLVVK--GLKENVEYHFRVSAENQFGISK 30312
Query: 484 --RFQEYI-----LALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKE 536
+ +E + L + PS+P +++++++++ +S+++P GG + Y ++ KE
Sbjct: 30313 PLKSEEPVTPKTPLNPPEPPSNP--PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKE 30370
Query: 537 VASEIWKIVRSHGVQ---TMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE 593
+++ W VR + Q TM + L P+ Y+ R+ A N G + +T P E
Sbjct: 30371 TSTDKW--VRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVG--------LSETSPASE 30420
Query: 594 P-------SPPSIHGQPSSGKSFKLSITKQ-----DDGGAPILEYIVKYRSKDKEDQWLE 641
P PS G+ K S+T Q DGG IL Y V+YR + + W +
Sbjct: 30421 PVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR-QSGDSAWKK 30479
Query: 642 KKVQGNKDHIILEHLQWTMG-------YEVQITAANRLGYSEPTVYEFSMPPK 687
+ KD Q+T+G YE ++ A N G S P S+ K
Sbjct: 30480 SNKERIKDK------QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTK 30526
Score = 70.5 bits (171), Expect = 6e-12
Identities = 107/506 (21%), Positives = 195/506 (38%), Gaps = 67/506 (13%)
Query: 221 TAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG--SNTELTVRNIINSDGGP 278
T + G ++ +G PEP I+W + +++++++ ++ + +T+ + SD G
Sbjct: 13701 TVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGT 13760
Query: 279 YVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVC----DAEGEPIPEITW 334
Y+ A N G + V +P + T N L D G I
Sbjct: 13761 YIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVV 13820
Query: 335 KRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASR----IGGHQ 390
+R ++ D + K + K KL + Y A+ +G
Sbjct: 13821 ER-----------RATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPV 13869
Query: 391 KSMYLDIEYA-----------PKFISNQTIYYSW------EGNPINISCDVKSNPPASIH 433
++ + +Y P I+ + +W G+PI + +P
Sbjct: 13870 QASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKW 13929
Query: 434 WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG----TRFQEYI 489
R +K+ P K+TT T +K R+ A N G ++ E I
Sbjct: 13930 VRCNKM--PVKDTTYRVKGLTNKKKY------------RFRVLAENLAGPGKPSKSTEPI 13975
Query: 490 LAL--ADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRS 547
L D P P + ++ +T+ ++++ KP+ GG I Y +++ + ++ W V
Sbjct: 13976 LIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAE 14035
Query: 548 HGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE--IFQTLPVREPSPP---SIHGQ 602
T +L L Y RV AVN G+ + S+ + + PSPP +
Sbjct: 14036 GVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINI 14095
Query: 603 PSSGKSFKLSITKQDDGGAPILEYIVKYRS-KDKEDQWLEKKVQGNKDHIILEHLQWTMG 661
+ K ++ ++ DGG+PI YIV+ R + K Q ++ V+ K + L
Sbjct: 14096 TKNTADLKWTVPEK-DGGSPITNYIVEKRDVRRKGWQTVDTTVKDTK--CTVTPLTEGSL 14152
Query: 662 YEVQITAANRLGYSEPTVYEFSMPPK 687
Y ++ A N +G S+ T E S+ K
Sbjct: 14153 YVFRVAAENAIGQSDYTEIEDSVLAK 14178
Score = 70.1 bits (170), Expect = 8e-12
Identities = 79/397 (19%), Positives = 156/397 (39%), Gaps = 21/397 (5%)
Query: 15 SSGQALLQVTISLSKVELSVGESKFFTCTA-IGEPESIDWYNPQGEKIISTQRVVVQKEG 73
+S + I ++S+ E + A I + W G ++ +++ G
Sbjct: 33031 ASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVL-NGVELTNSEEYRYGVSG 33089
Query: 74 VRSRLTIYNANIEDAGIYRCQATDAKGQTQ---EATVVLEIYQKLTFREVVSPQEFKQGE 130
LTI A+ D GI C + +G + + T+ E+ F Q +G+
Sbjct: 33090 SDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQ 33149
Query: 131 DAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLAN-NNLQILNINKSDEGIYRCEGR 189
+ C +S P+P + W +N ++ S+ + N +L+I N + SD G Y + +
Sbjct: 33150 NVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAK 33209
Query: 190 VEARGEIDFRDIIVIVNV--PPAISMPQKSFNATAERGEEMTFSCRASGS-PEPAISWFR 246
RG+ ++++ + P+ + ++ T+ +G + S + S S E + S F
Sbjct: 33210 -NFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFS 33268
Query: 247 NGKLIEENEKYILKGSNTELT--VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ--- 301
+ E S ++ + + ++ + E L+ ++
Sbjct: 33269 SSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIP 33328
Query: 302 PHIIQLKNETTYENGQV-TLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH 360
P I L ++ + + G+V T+ C GEP PE+TW E GR ++
Sbjct: 33329 PKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQE-----QGRFHIENTD 33383
Query: 361 GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI 397
++L I DV+ D G Y + G ++ + I
Sbjct: 33384 DLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/278 (22%), Positives = 119/278 (42%), Gaps = 9/278 (3%)
Query: 404 ISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIA 463
I+NQ I G+P I + P + W+ +++ L K T + +T + L +
Sbjct: 28652 ITNQLITCK-AGSPFTIDVPISGRPAPKVTWKLEEMRL--KETDRVSITTTKDRTTLTVK 28708
Query: 464 PTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSH 522
+ D GRY T N G + + + P G +++ +S + +S+ +P
Sbjct: 28709 DSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDG 28768
Query: 523 GGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSK 582
GG I +Y V+ +E + W++V S +T + + +L Y RV++ N G +
Sbjct: 28769 GGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLE 28828
Query: 583 ----IEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQ 638
I +P P+ P ++ ++ S + DGG+ I+ Y V+ + ++
Sbjct: 28829 SAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE-EPYHDGGSKIIGYWVEKKERNTILW 28887
Query: 639 WLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSE 676
E KV + + + L + Y+ + A N G S+
Sbjct: 28888 VKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSK 28925
Score = 69.7 bits (169), Expect = 1e-11
Identities = 77/373 (20%), Positives = 137/373 (36%), Gaps = 32/373 (8%)
Query: 130 EDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNN-LQILNINKSDEGIYRC-- 186
E +V + + + A V W+ + E+T + R+ + ++ L I + DEGI C
Sbjct: 33052 EGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCIS 33111
Query: 187 ---EGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS 243
EG V+ + ++ + + P IS P+ G+ + F+C SG P P I
Sbjct: 33112 KTKEGIVKCQYDLTLSK--ELSDAPAFISQPRSQ---NINEGQNVLFTCEISGEPSPEIE 33166
Query: 244 WFRNGKLIEENEKYILKGSNT--ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ 301
WF+N I + + S L +RN SD G Y +A N G+ A L V
Sbjct: 33167 WFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL-- 33224
Query: 302 PHIIQLKNETTYE-NGQVTLVCDAEGEPIPEITWKR--AVDGFTFTEGDKSLDGRIEVKG 358
P + + E +G +L + + K+ + F+ + + +
Sbjct: 33225 PLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMS 33284
Query: 359 QHGSSSLHIKDVKLSDSG--------RYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIY 410
SS+ V++S S + + + + + + IE P IS
Sbjct: 33285 AQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISID--- 33341
Query: 411 YSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDF 470
EG + ++C P + W + ++ +T L I D
Sbjct: 33342 ---EGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDG 33398
Query: 471 GRYNCTATNHIGT 483
G Y + N G+
Sbjct: 33399 GLYTLSLGNEFGS 33411
Score = 69.3 bits (168), Expect = 1e-11
Identities = 71/289 (24%), Positives = 118/289 (40%), Gaps = 21/289 (7%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G I K P I W R++ + T ++ L I ND G+Y
Sbjct: 24039 GGSARIHIPFKGRPTPEITWSREE----GEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYI 24094
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
N G++ + + D P P + + E+ + +A + + P GG + +Y +D
Sbjct: 24095 LKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDK 24154
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP 594
+E + + V S +T + NL Y RV A N G G + + V+
Sbjct: 24155 RESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVG----VPVETVDAVKAA 24210
Query: 595 SPPSIHGQPS----SGKSFKLSITK-QDDGGAPILEYIVKYRSKDKEDQW---LEKKVQG 646
PPS G+ + S S L K + DGG+ +L Y+V+ + K E +W E KV
Sbjct: 24211 EPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTE-KWSIVAESKV-- 24267
Query: 647 NKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTL 695
+ ++ L Y+ ++ A N G S+P V + K I+ +L
Sbjct: 24268 --CNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSL 24314
Score = 68.9 bits (167), Expect = 2e-11
Identities = 112/516 (21%), Positives = 193/516 (37%), Gaps = 67/516 (12%)
Query: 302 PHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHG 361
P I+ + T ++ + G+P P WK+ D + + V
Sbjct: 18900 PKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGED-------EVVTSSHLAVHKADS 18952
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP---------KFISNQTIYYS 412
SS L IKDV DSG Y A + G + + + + AP I S
Sbjct: 18953 SSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLS 19012
Query: 413 W----EGNPINIS------CDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEI 462
W E NI+ CDV + L K + + G++ I +
Sbjct: 19013 WHIPLEDGGSNITNYIVEKCDVSRGDWVTA------LASVTKTSCRVGKLIPGQEYIFRV 19066
Query: 463 APTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSH 522
++N FG + + +F VPS P ++ ++++ V++++PDS
Sbjct: 19067 R--AENRFGISEPLTSPKMVAQFP------FGVPSEPKNARVTKVNKDCIFVAWDRPDSD 19118
Query: 523 GGVPIHHYQVDVKEVASEIW-----KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQ 577
GG PI Y ++ KE S +W +VRS ++ LE Y R+ A+N G
Sbjct: 19119 GGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLE----YSFRIYALNKAGS 19174
Query: 578 GDYSKIEIFQT--LPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDK 635
SK + T +PV P P + S S + K DGG+ I+ Y V+ K
Sbjct: 19175 SPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH-DGGSKIIGYFVE-ACKLP 19232
Query: 636 EDQWLEKKV---QGNKDHIILEHLQWTMGYEVQITAANRLGYSEP-------TVYEFSMP 685
D+W+ Q ++ L+ Y+ + A + S P T+ ++P
Sbjct: 19233 GDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVP 19292
Query: 686 PKPNI---IKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQC-GLLMCITRRMCG 741
P+ ++ +K L G + V + V ++ G+ M + R +C
Sbjct: 19293 PRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCT 19352
Query: 742 KKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDE 777
+ S + + A GSK ++++ D+
Sbjct: 19353 LELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDK 19388
Score = 68.6 bits (166), Expect = 2e-11
Identities = 95/402 (23%), Positives = 158/402 (39%), Gaps = 53/402 (13%)
Query: 305 IQLKNETTYENGQVTLV-CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS 363
++ ++ + G+V + D G P+P I+W A DG E R E+ +
Sbjct: 25793 VKFRDVIVVKAGEVLKINADIAGRPLPVISW--AKDGIEIEER-----ARTEIISTDNHT 25845
Query: 364 SLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPIN-ISC 422
L +KD D+G+Y + G ++ + P G P +
Sbjct: 25846 LLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKP-------------GPPAGPLEI 25892
Query: 423 DVKSNPPASIHWRR---------DKLVLPAKNTTNLK-TYSTGRKMILEIAPTS---DND 469
+ + S+ W R D ++ + T++L T G + T N+
Sbjct: 25893 NGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNE 25952
Query: 470 FGRYNCTATNH--IGTRFQEYILALAD---VPSSPYGVKIIELSQTTAKVSFNKPDSHGG 524
+ + T N +G + + D VPS P ++I +++ + + +++P+S GG
Sbjct: 25953 Y-IFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGG 26011
Query: 525 VPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNN-LEPNTTYEIRVAAVNGKGQGDYSKI 583
I Y ++ +E S W V V + V + L YE RV A N G S+
Sbjct: 26012 SEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSET 26071
Query: 584 E--IFQTLPVREPSPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKE 636
I PV PSPPS +P S K +IT DGGAPI Y V+Y+ D
Sbjct: 26072 SPLIRAEDPVFLPSPPS---KPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDT 26128
Query: 637 DQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
D W + L Y ++ + N++G S+P+
Sbjct: 26129 D-WKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 26169
Score = 68.2 bits (165), Expect = 3e-11
Identities = 69/296 (23%), Positives = 121/296 (40%), Gaps = 23/296 (7%)
Query: 410 YYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDND 469
Y + E + + +K P S+ W++ + P T + S+ L + +D
Sbjct: 19992 YLAKENSNFRLKIPIKGKPAPSVSWKKGED--PLATDTRVSVESSAVNTTLIVYDCQKSD 20049
Query: 470 FGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIH 528
G+Y T N GT+ + + P P G +K E++ + + P GG I
Sbjct: 20050 AGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEIT 20109
Query: 529 HYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE-IFQ 587
+Y ++ ++ + W S +T + L Y RV+A N G G+ K E I
Sbjct: 20110 NYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVA 20169
Query: 588 TLPV---REPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKV 644
P P PP+I S + K+ GG+PI Y ++++ + + L K+
Sbjct: 20170 RHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKK-TGGSPITGYHLEFKER---NSLLWKR- 20224
Query: 645 QGNKDHIILEHLQWT-----MGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTL 695
NK I + + T + YE ++ A N G +P S+P +P + D +
Sbjct: 20225 -ANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKP-----SLPSEPVVALDPI 20274
Score = 68.2 bits (165), Expect = 3e-11
Identities = 71/275 (25%), Positives = 115/275 (41%), Gaps = 20/275 (7%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G+ +++ K P SI W +D L P K + ++ T K+ L I G+Y
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDGL--PLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 27635
Query: 475 CTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 533
N + + PS P G ++ E+ + +S++ P+ +GG I Y ++
Sbjct: 27636 VILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE 27695
Query: 534 VKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVN--GKGQGDYSKIEIFQTLPV 591
+E + WK+V S +T + NL + Y+ RV A N G Q S I I
Sbjct: 27696 KRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSI-IVAKHQF 27754
Query: 592 REPSPPS---IHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNK 648
R P PP I+ S G S DGG+ + + V+ K + + L +KV N
Sbjct: 27755 RIPGPPGKPVIYNVTSDGMSLTWDAPVY-DGGSEVTGFHVE---KKERNSILWQKV--NT 27808
Query: 649 DHIILEHLQWT-----MGYEVQITAANRLGYSEPT 678
I + T + Y+ ++ A N G S P+
Sbjct: 27809 SPISGREYRATGLVEGLDYQFRVYAENSAGLSSPS 27843
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/206 (26%), Positives = 95/206 (46%), Gaps = 15/206 (7%)
Query: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVV 555
PS P +++I +++ TA + + P+ GG PI +Y V+ ++V + W+ V + T
Sbjct: 14084 PSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCT 14143
Query: 556 LNNLEPNTTYEIRVAAVNGKGQGDYSKIE--IFQTLPVREPSPP---SIHGQPSSGKSFK 610
+ L + Y RVAA N GQ DY++IE + P PP ++ K
Sbjct: 14144 VTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLK 14203
Query: 611 LSITKQDDGGAPILEYIVKYRSKDKEDQWLEK-KVQGNKDHIILEHLQWTMGYEVQITAA 669
K +DGG PI Y+++ + + +W++ K G + + + + Q+ A
Sbjct: 14204 WEPPK-NDGGRPIQRYVIEKKER-LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAE 14261
Query: 670 NRLGY---SEPT----VYEFSMPPKP 688
N G SEPT + + + PP P
Sbjct: 14262 NEAGVGHPSEPTEILSIEDPTSPPSP 14287
Score = 67.4 bits (163), Expect = 5e-11
Identities = 151/716 (21%), Positives = 278/716 (38%), Gaps = 87/716 (12%)
Query: 27 LSKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
+ V +GE+ +C +G P I WY G+++I +++ + +G LT+
Sbjct: 30539 MKDVTTKLGEAAQLSCQIVGRPLPDIKWYR-FGKELIQSRKYKMSSDGRTHTLTVMTEEQ 30597
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQ----GEDAEVVCRVSSS 141
ED G+Y C AT+ G+ + ++ +L Q P + K G +
Sbjct: 30598 EDEGVYTCIATNEVGEVETSSKLL--LQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGR 30655
Query: 142 PAPAVSW------LYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
P PA++W L ++E +T + + L N+Q K+ G Y +V+
Sbjct: 30656 PVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQ----RKTHAGKY----KVQLSNV 30707
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKL----I 251
D I+ V + P A S + + SW N +
Sbjct: 30708 FGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPA--DDGGSWITNYVVEKCEA 30765
Query: 252 EENEKYILKGSNTELTVRNIIN-SDGGPYVCR--ATNKAGEDEKQAFLQVFVQPHIIQLK 308
+E ++ L S +T I+N ++ Y R A N G + V II+
Sbjct: 30766 KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVV----IIKSP 30821
Query: 309 NETTYENGQVTLVCDAEGEPIPEITWK-RAVDG------FTFTEGDKSLDGRIEVKGQH- 360
E G+ T+ + + + WK A DG + + +K + I V +
Sbjct: 30822 FEKPGAPGKPTITAVTKDSCV--VAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEI 30879
Query: 361 GSSSLHIKDV--KLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKF-ISNQTIYYSWEGNP 417
+ +K++ L R CE +GG + + PK + Q ++ E
Sbjct: 30880 RETVFSVKNLIEGLEYEFRVKCE---NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN 30936
Query: 418 INIS--------CDVKSNPPASIHW-RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDN 468
+N+ C V +P + W R+ K ++ ++ + G ++ IA +D+
Sbjct: 30937 LNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLI-IASVTDD 30995
Query: 469 DFGRYNCTATNHIGT-----RFQEYILALADVPSSPYGVKIIELSQ---TTAKVSFN-KP 519
D Y ATN G+ + + A +P + G+ + + + K+ F+ KP
Sbjct: 30996 DATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKP 31055
Query: 520 DSHGGVPIHHYQVDVKEVASE-IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQG 578
D P+ +Q + + ++++ + ++V N +E V A N G
Sbjct: 31056 D-----PVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI- 31109
Query: 579 DYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITK-QDDGGAPILEYIVKYRSKDKED 637
D +E+ V +P P + S S L+ T+ DGG+ I YIV+ + +
Sbjct: 31110 DQKTVEL-DVADVPDP-PRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVE-KCATTAE 31166
Query: 638 QWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKD 693
+WL + Q + + +L Y+ ++ A N+ G S+P S P +P I K+
Sbjct: 31167 RWL-RVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKP-----SEPSEPTITKE 31216
Score = 67.0 bits (162), Expect = 7e-11
Identities = 99/428 (23%), Positives = 173/428 (40%), Gaps = 47/428 (10%)
Query: 274 SDGGPYVCR--ATNKAGEDEKQAFL------QVFVQPHIIQLKNETTYENGQ-VTLVCDA 324
+ G Y+ R A N+ G + ++ + ++P + + + + GQ + +
Sbjct: 23194 TQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPI 23253
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
G P P ITW + DG + RI V ++L IK+ D G+Y A+
Sbjct: 23254 SGRPKPTITWTK--DGLPLKQTT-----RINVTDSLDLTTLSIKETHKDDGGQYGITVAN 23306
Query: 385 RIGGHQKSMY---LDIEYAPKF------ISNQTIYYSWEGNPINISCD-----VKSNPPA 430
+G S+ LD PK +S ++I SW C V+
Sbjct: 23307 VVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTT 23366
Query: 431 SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
+ W + A+ T + TG + I ++N +G+ ++ I +Y
Sbjct: 23367 TTVWDVVSATV-ARTTLKVTKLKTGTEYQFRIF--AENRYGQSFALESDPI---VAQYPY 23420
Query: 491 ALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW-KIVRSHG 549
P +P+ I S+ + + +++P ++GG P+ Y ++ KE S +W K+ ++
Sbjct: 23421 KEPGPPGTPFATAI---SKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII 23477
Query: 550 VQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSF 609
T NLE YE RV A N G G SK + R+P P +P K
Sbjct: 23478 HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNS--ECYVARDPCDPPGTPEPIMVKRN 23535
Query: 610 KLSI--TKQ-DDGGAPILEYIVKYRSKDKEDQWLEKKVQG-NKDHIILEHLQWTMGYEVQ 665
++++ TK DGG+ I YIV+ R + +W++ + + L YE +
Sbjct: 23536 EITLQWTKPVYDGGSMITGYIVEKRDL-PDGRWMKASFTNVIETQFTVSGLTEDQRYEFR 23594
Query: 666 ITAANRLG 673
+ A N G
Sbjct: 23595 VIAKNAAG 23602
Score = 67.0 bits (162), Expect = 7e-11
Identities = 67/268 (25%), Positives = 113/268 (42%), Gaps = 34/268 (12%)
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
+G P PEITW R FT +++++ + L I + +D+G+Y + +
Sbjct: 24049 KGRPTPEITWSREEGEFT---------DKVQIEKGVNYTQLSIDNCDRNDAGKYILKLEN 24099
Query: 385 RIGGHQKSMYLDIE----------YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHW 434
G KS ++ ++ A K + + + WE I+ VK ++
Sbjct: 24100 SSG--SKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVK-------NY 24150
Query: 435 RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQ-EYILAL- 492
DK K N+ S K ++ ++ + A N G E + A+
Sbjct: 24151 VIDKRESTRKAYANVS--SKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVK 24208
Query: 493 -ADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQ 551
A+ PS P V + ++SQT+A + + KP+ GG + Y V+++ +E W IV V
Sbjct: 24209 AAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVC 24268
Query: 552 TMVVLNNLEPNTTYEIRVAAVNGKGQGD 579
VV L Y+ RV A N KG+ D
Sbjct: 24269 NAVV-TGLSSGQEYQFRVKAYNEKGKSD 24295
Score = 67.0 bits (162), Expect = 7e-11
Identities = 84/369 (22%), Positives = 149/369 (40%), Gaps = 36/369 (9%)
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
+G P+P +TW + DG E +K ++ +E+ GS+SL ++D G Y EA +
Sbjct: 27983 QGRPVPRVTWFK--DG---VEIEKRMN--MEITDVLGSTSLFVRDATRDHRGVYTVEAKN 28035
Query: 385 RIGGHQKSMYLDIEYAPKFISNQTIYYS--------WEGNPINISCD------VKSNPPA 430
G + + + ++ P + + + W P+N C ++ +
Sbjct: 28036 ASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETS 28095
Query: 431 SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
+ W + A++ T +K + + ++ N FG ++ + + Q
Sbjct: 28096 RLAWALIEDKCEAQSYTAIKLINGNE---YQFRVSAVNKFGVGRPLDSDPVVAQIQ---Y 28149
Query: 491 ALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW-KIVRSHG 549
+ D P P I S T +++ +P+S GG I Y ++ +E S W K++
Sbjct: 28150 TVPDAPGIPEPSNITGNSIT---LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRP 28206
Query: 550 V-QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE--IFQTLPVREPSPPSIHGQPSSG 606
+ +T + L YE V A N G G S I I PV P PP++ +
Sbjct: 28207 ISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTS 28266
Query: 607 K-SFKLSITKQ-DDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEV 664
K + L +K DGG I+ YI++ D D K + LQ Y+
Sbjct: 28267 KTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKF 28326
Query: 665 QITAANRLG 673
+++A N G
Sbjct: 28327 RVSAINGAG 28335
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/187 (29%), Positives = 84/187 (44%), Gaps = 17/187 (9%)
Query: 209 PAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE----KYILKGSNT 264
P + P +S G TF SG P P +SWFR+G++I + +
Sbjct: 6 PTFTQPLQS--VVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 265 ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ---PHIIQ-LKNETTYENGQVTL 320
+LT+ + ++ G Y +ATN +G+ A L V + P+ +Q L++ T + QV L
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 321 VCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDC 380
G P P + + R DG E SLD +I +G SL I + DSG Y
Sbjct: 124 QVRVTGIPTPVVKFYR--DG---AEIQSSLDFQISQEGD--LYSLLIAEAYPEDSGTYSV 176
Query: 381 EAASRIG 387
A + +G
Sbjct: 177 NATNSVG 183
Score = 65.5 bits (158), Expect = 2e-10
Identities = 96/425 (22%), Positives = 171/425 (40%), Gaps = 49/425 (11%)
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYD 379
L D G+PIP++ W + DG E R+E+K ++L +KD +D G+Y
Sbjct: 24727 LEADIRGKPIPDVVWSK--DGKELEE----TAARMEIKSTIQKTTLVVKDCIRTDGGQYI 24780
Query: 380 CEAASRIGGHQKSMYLDIEYAPK-----------FISNQTIYYSW----EGNPINIS-CD 423
+ S +GG KS+ + ++ + ++ + Y +W + NIS
Sbjct: 24781 LKL-SNVGG-TKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYI 24838
Query: 424 VKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
++ + + W + + A N K G + I + N +G + + T
Sbjct: 24839 IEKRETSRLSWTQVSTEVQALNYKVTKLLP-GNEYIFRVMAV--NKYGIGEPLESGPV-T 24894
Query: 484 RFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW- 542
Y P P ++ +++ + V++ +P GG I Y ++ ++ W
Sbjct: 24895 ACNPY-----KPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWT 24949
Query: 543 KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIF-----QTLPVREPSPP 597
K + + + L +YE RVAA N G G+ S+ +F P PS P
Sbjct: 24950 KCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNP 25009
Query: 598 SIHGQPSSGKSFKLSITKQ-DDGGAPILEYIVKYRSKDKEDQWL----EKKVQGNKDHII 652
+ +S S L+ +K DGGAP+ Y+V+ + + D+W +QG +
Sbjct: 25010 KV--TDTSRSSVSLAWSKPIYDGGAPVKGYVVEVK-EAAADEWTTCTPPTGLQGKQ--FT 25064
Query: 653 LEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAAL 712
+ L+ Y +I A N G EP S+ + I + L V+ L +A
Sbjct: 25065 VTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASAT 25124
Query: 713 LLILV 717
L + V
Sbjct: 25125 LRLFV 25129
Score = 65.1 bits (157), Expect = 3e-10
Identities = 92/381 (24%), Positives = 154/381 (40%), Gaps = 55/381 (14%)
Query: 326 GEPIPEITWKRAVDGFTFTEGDK-SLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
G P+P W T+G + D V+ + SS L IK+ D+G Y ++
Sbjct: 17536 GVPVPTAKWT--------TDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSN 17587
Query: 385 RIGGHQKSMYLDIEYAPK---------FISNQTIYYSWE------GNPINISCDVKSNPP 429
G +++L + P ++ + + SW+ G+P+ I+ V+
Sbjct: 17588 AAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPV-INYIVEKQDT 17646
Query: 430 ASIHWRRDKLVLPAKNTTNLKT--YSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
W +V + T LK G + + + + G + +F
Sbjct: 17647 RKDTWG---VVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFS- 17702
Query: 488 YILALADVPSSPYGVKII-ELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVR 546
P SP G ++ ++++ A VS+ P S GG PI Y ++ +EV + ++ +
Sbjct: 17703 --------PPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNK 17754
Query: 547 SHGVQTMVVLNNLEPNTTYEIRVAAVN--GKGQGDYSKIEIFQTLPVREPSPP-SIHGQP 603
+ + L TYE RV A N G + S I P++ P PP + +
Sbjct: 17755 TPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKD 17814
Query: 604 SSGKSFKLSITKQ-DDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMG- 661
S ++ L TK DGG+PIL Y+V+ + K QW + NKD +I + G
Sbjct: 17815 KSRETADLVWTKPLSDGGSPILGYVVECQ-KPGTAQW----NRINKDELIRQCAFRVPGL 17869
Query: 662 -----YEVQITAANRLGYSEP 677
Y +I AAN +G EP
Sbjct: 17870 IEGNEYRFRIKAANIVGEGEP 17890
Score = 64.3 bits (155), Expect = 4e-10
Identities = 85/384 (22%), Positives = 145/384 (37%), Gaps = 48/384 (12%)
Query: 314 ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS 373
EN L +G+P P ++WK+ D + D R+ V+ +++L + D + S
Sbjct: 19996 ENSNFRLKIPIKGKPAPSVSWKKGEDPL-------ATDTRVSVESSAVNTTLIVYDCQKS 20048
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPIN-ISCDVKSNPPASI 432
D+G+Y + G + ++ + + P G P I D + ++
Sbjct: 20049 DAGKYTITLKNVAGTKEGTISIKVVGKP-------------GIPTGPIKFDEVTAEAMTL 20095
Query: 433 HWRRDK---------LVLPAKNTTNLKTY---STGRKMILEIAPTSDNDFGRYNCTATNH 480
W K +L +++ N K S +K + + + +A N
Sbjct: 20096 KWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENK 20155
Query: 481 IGTRF---QEYILALA--DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVK 535
G E I+A DVP +P I+++ + +++ P GG PI Y ++ K
Sbjct: 20156 YGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFK 20215
Query: 536 EVASEIWKIVRSHGVQTM-VVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP 594
E S +WK ++ + L YE RV A+N G G S + PV
Sbjct: 20216 ERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPS----LPSEPVVAL 20271
Query: 595 SPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD 649
P G+P + S+T + DGG + YIV+ R + V +
Sbjct: 20272 DPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPEC 20331
Query: 650 HIILEHLQWTMGYEVQITAANRLG 673
+ L YE +I A N G
Sbjct: 20332 AFTVTDLVEGGKYEFRIRAKNTAG 20355
Score = 63.9 bits (154), Expect = 6e-10
Identities = 116/552 (21%), Positives = 202/552 (36%), Gaps = 89/552 (16%)
Query: 190 VEARGEIDFRDIIVIVNVPPAISMPQKSFNATAER------GEEMTFSCRASGSPEPAIS 243
V A GE D + V V + P+ +A R G+ + S G P P ++
Sbjct: 17192 VNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVT 17251
Query: 244 WFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP- 302
W + + + + ++L +RN + DGG Y N AG + V +P
Sbjct: 17252 WKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPG 17311
Query: 303 -----HIIQLKNETTY--------ENGQVTL--------VCDAEGEPIPEITWKRAVDGF 341
+ +++ ++ Y + G V V A+ P+ + K++
Sbjct: 17312 PPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAK 17371
Query: 342 TFTEGDKSLDGRIEVKGQHGSSSL--HIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEY 399
EG++ L R+ + Q+G K +K D H D+ +
Sbjct: 17372 HLNEGNQYL-FRVAAENQYGRGPFVETPKPIKALDP------------LHPPGPPKDLHH 17418
Query: 400 APKFISNQTIYYSWE------GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYS 453
+ + W G+PI V+ + W + K TNL+
Sbjct: 17419 VD--VDKTEVSLVWNKPDRDGGSPIT-GYLVEYQEEGTQDW------IKFKTVTNLECVV 17469
Query: 454 TGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILAL-----ADVPSSPYGVKIIELS 508
TG L+ T R+ A N +G + + + PS VK+IE
Sbjct: 17470 TG----LQQGKTY-----RFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGL 17520
Query: 509 QTTAKVSFNKPDSHGGVPI--HHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYE 566
A + P GVP+ + D E+ ++ V + +++ + N T E
Sbjct: 17521 VVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGE 17580
Query: 567 IRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQ---DDGGAPI 623
++ N G SK + P PP+ ++I+ Q DDGG+P+
Sbjct: 17581 YQITVSNAAG----SKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPV 17636
Query: 624 LEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGY-----SEPT 678
+ YIV+ + ++D W +K + + HLQ Y ++ A N++G S PT
Sbjct: 17637 INYIVE-KQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPT 17695
Query: 679 V--YEFSMPPKP 688
V ++FS P P
Sbjct: 17696 VAKHKFSPPSPP 17707
Score = 63.5 bits (153), Expect = 8e-10
Identities = 65/271 (23%), Positives = 109/271 (40%), Gaps = 40/271 (14%)
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
+G P PE+ W++A + L R +++ + L I +V DSGRY+ +
Sbjct: 25132 KGRPEPEVKWEKA---------EGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLEN 25182
Query: 385 RIGGHQKSM---YLDIEYAP-----KFISNQTIYYSWEGNPINISCDVKSNPPASIHWRR 436
G + LD AP + + ++ SWE PP +
Sbjct: 25183 NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWE-------------PPLIDGGAK 25229
Query: 437 DKLVLPAKNTTNLKTYST----GRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYI--- 489
+ K T K Y+T K I + + A+N G
Sbjct: 25230 ITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEP 25289
Query: 490 LALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHG 549
+ +++ P P V ++++++ TA + + KP+S GG I Y V+++ SE W
Sbjct: 25290 VKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQ-- 25347
Query: 550 VQTM-VVLNNLEPNTTYEIRVAAVNGKGQGD 579
V+T+ ++ L Y RVAAVN KG+ D
Sbjct: 25348 VKTLEATISGLTAGEEYVFRVAAVNEKGRSD 25378
Score = 63.5 bits (153), Expect = 8e-10
Identities = 66/287 (22%), Positives = 115/287 (40%), Gaps = 25/287 (8%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G + + + P +I W +D L ++ + ++++ A ++ G Y
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNS--GCYE 26944
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAK---VSFNKPDSHGGVPIHHYQ 531
N +G+ + + D P P G IE TA+ + + P GG I HY
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPGGP--IEFKTVTAEKITLLWRPPADDGGAKITHYI 27002
Query: 532 VDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGD-YSKIEIFQTLP 590
V+ +E + +W +V H + ++ + Y RV AVN G G+ +
Sbjct: 27003 VEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNA 27062
Query: 591 VREPSPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQW---LEK 642
P PP I P K K S+T DGG+ I Y ++ R K K W L++
Sbjct: 27063 FVTPGPPGI---PEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDK-KSLGWFKVLKE 27118
Query: 643 KVQGNKDHIILEHLQWTMGYEVQITAANRLG---YSEPTVYEFSMPP 686
++ + + L Y+ ++ A N G +SEP+ + + P
Sbjct: 27119 TIRDTRQKV--TGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADP 27163
Score = 62.8 bits (151), Expect = 1e-09
Identities = 109/476 (22%), Positives = 177/476 (37%), Gaps = 77/476 (16%)
Query: 248 GKLIEENEK------YILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV- 300
G +IE K +I E VRN+ + + A N AG + V V
Sbjct: 20998 GYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVK 21057
Query: 301 -QPHIIQLKNETTYENGQVTLVCD-------AEGEPIPEITWKRAVDGFTFTEGDKSL-- 350
Q + +L Y+ + D G P P +TWK+ GD+ L
Sbjct: 21058 EQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKK---------GDQILKQ 21108
Query: 351 DGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP-------KF 403
R+ + S+ L+I + SDSG Y A + +G + + + P KF
Sbjct: 21109 TQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKF 21168
Query: 404 --ISNQTIYYSWE------GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTG 455
+S+ + +SW+ G PI+ + V+ S W + + T +TG
Sbjct: 21169 DEVSSDFVTFSWDPPENDGGVPIS-NYVVEMRQTDSTTW-VELATTVIRTTYKATRLTTG 21226
Query: 456 RKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVS 515
+ + + G +A F+ VP P ++ +++ + +S
Sbjct: 21227 LEYQFRVKAQNRYGVGPGITSACIVANYPFK--------VPGPPGTPQVTAVTKDSMTIS 21278
Query: 516 FNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNN-LEPNTTYEIRVAAVNG 574
+++P S GG PI Y V+ KE +W+ V V + ++ L YE RV A N
Sbjct: 21279 WHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENM 21338
Query: 575 KGQGDYSKIEIFQTLPVREPSPPSIHGQP--SSGKSFKLSITK----------QDDGGAP 622
G+ SK PS P + P GK L+IT+ + GG
Sbjct: 21339 AGKSKPSK-----------PSEPMLALDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFK 21387
Query: 623 ILEYIVKYRSKDKEDQWLEKKVQG-NKDHIILEHLQWTMGYEVQITAANRLGYSEP 677
I YIV+ R +WL+ ++ + L YE ++ A N G P
Sbjct: 21388 ITSYIVEKRDL-PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISP 21442
Score = 62.4 bits (150), Expect = 2e-09
Identities = 65/269 (24%), Positives = 118/269 (43%), Gaps = 17/269 (6%)
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G I I +K P + W +D + L KN N++ +T +L I + D G++
Sbjct: 20791 GLSIRIFVPIKGRPAPEVTWTKDNINL--KNRANIE--NTESFTLLIIPECNRYDTGKFV 20846
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
T N G + + + D P ++ ++++ + + ++ P GG I +Y V+
Sbjct: 20847 MTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEK 20906
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVR-- 592
+E + + + + + L Y RV A N G G+ ++ T PV+
Sbjct: 20907 REATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTE----TTEPVKAS 20962
Query: 593 -EPSPP-SIHGQPSSGKSFKLSITK-QDDGGAPILEYIVKYRSKDKEDQWLE-KKVQGNK 648
PSPP S++ + + L+ K + DGG+ I Y+++ + K DQW V+G +
Sbjct: 20963 EAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKG-SDQWTHITTVKGLE 21021
Query: 649 DHIILEHLQWTMGYEVQITAANRLGYSEP 677
++ +L Y Q+ A N G S P
Sbjct: 21022 --CVVRNLTEGEEYTFQVMAVNSAGRSAP 21048
Score = 62.4 bits (150), Expect = 2e-09
Identities = 86/403 (21%), Positives = 139/403 (34%), Gaps = 114/403 (28%)
Query: 103 QEATVVLEIYQKLTFREVVSPQEFK--QGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISD 160
+E + +I L R + P+ +GE A C P P V+WL + ++T +
Sbjct: 32547 EEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSAR 32606
Query: 161 NRFAMLA-NNNLQILNINKSDEGIY-----RCEGRVEARGEIDFRDIIVI---VNVPPAI 211
++ + +I ++ SDEG Y EG+ EA + + V V PP +
Sbjct: 32607 HQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRV 32666
Query: 212 SMPQ-----------------------KSFNAT------AERGEEMTFSC--------RA 234
P+ K+ + T E+ + + S +A
Sbjct: 32667 KSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKA 32726
Query: 235 SGSPEPA---------------ISWFRNGKLIEENEKYILKGS---NTELTVRNIINSDG 276
S E A ++W+++GK ++EN + S EL + N+ SD
Sbjct: 32727 EASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQ 32786
Query: 277 GPYVCRATNKAGEDEK------QAFLQVFVQ----------------------------- 301
G YVC + + G + QAF + +
Sbjct: 32787 GEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPE 32846
Query: 302 -----PHIIQLKNETTYENGQVT-LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIE 355
P I+ +TT + V A GEP P W + DG T+G G+ +
Sbjct: 32847 PISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK--DGKAITQG-----GKYK 32899
Query: 356 VKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
+ G L I SDSG Y C + G S L I+
Sbjct: 32900 LSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIK 32942
Score = 62.0 bits (149), Expect = 2e-09
Identities = 118/522 (22%), Positives = 196/522 (37%), Gaps = 63/522 (12%)
Query: 58 GEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTF 117
G+++ + RV + + L I + EDAG Y A G + V + +T
Sbjct: 2392 GQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSF-TIPALGLSTSGRVSVYSVDVITP 2450
Query: 118 REVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNIN 177
+ V+ E G A + C+VS +V W ++E++ D+R + Q L IN
Sbjct: 2451 LKDVNVIE---GTKAVLECKVSVPDVTSVKWYLNDEQIK--PDDRVQAIVKGTKQRLVIN 2505
Query: 178 K---SDEGIYR-CEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCR 233
+ SDEG Y+ GRVE + I +I + + T + + F
Sbjct: 2506 RTHASDEGPYKLIVGRVETNCNLSVEKIKIIRGLR----------DLTCTETQNVVFEVE 2555
Query: 234 ASGSPEPAISWFRNGKLIEENEKYILK--GSNTELTVRNIINSDGGPYVCRATNKAGEDE 291
S S + W K I+ + KY ++ G +LTV N++ D G Y T AGE+
Sbjct: 2556 LSHSGIDVL-WNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKY----TFYAGENM 2610
Query: 292 KQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLD 351
L V L ++T E+ + C+ P + W R DG L
Sbjct: 2611 TSGKLTVAGGAISKPLTDQTVAESQEAVFECEV-ANPDSKGEWLR--DG-----KHLPLT 2662
Query: 352 GRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYA--PKFISNQTI 409
I + L I KL D G Y + A+ + S L +E K + N T+
Sbjct: 2663 NNIRSESDGHKRRLIIAATKLDDIGEYTYKVAT----SKTSAKLKVEAVKIKKTLKNLTV 2718
Query: 410 YYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDND 469
E + ++ + W ++ +VL + + T + ++ D
Sbjct: 2719 ---TETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDES 2775
Query: 470 -----FGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGG 524
GR +A H+ T + P V +E A V+F SH
Sbjct: 2776 VYGFRLGRLGASARLHVET---------VKIIKKPKDVTALE----NATVAFEVSVSHDT 2822
Query: 525 VPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYE 566
VP+ + V+ S+ ++V V + +L N+ P+ E
Sbjct: 2823 VPVKWFHKSVEIKPSDKHRLVSERKVHKL-MLQNISPSDAGE 2863
Score = 61.2 bits (147), Expect = 4e-09
Identities = 71/329 (21%), Positives = 112/329 (34%), Gaps = 76/329 (23%)
Query: 156 TTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQ 215
TT+ + RF +L ++ RV A EI PP +
Sbjct: 909 TTVREERFEVLHGREAKVTET-----------ARVPAPVEIPV--------TPPTLVSGL 949
Query: 216 KSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKY--ILKGSNTELTVRNIIN 273
K N T GE +T C SG P P ++W+R IE + + + L +R
Sbjct: 950 K--NVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFA 1007
Query: 274 SDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEIT 333
D G + C A N+AG +L V V + + ETT +T
Sbjct: 1008 EDSGRFTCSAVNEAGTVSTSCYLAVQVSE---EFEKETT------------------AVT 1046
Query: 334 WKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSM 393
K + F E +DV ++D+ + +A G + +
Sbjct: 1047 EKFTTEEKRFVES---------------------RDVVMTDTSLTEEQA----GPGEPA- 1080
Query: 394 YLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYS 453
AP FI+ + EG + C V NP ++W++ + L +
Sbjct: 1081 ------APYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNK 1134
Query: 454 TGRKMILEIAPTSDNDFGRYNCTATNHIG 482
+ L I+ T +D G Y N G
Sbjct: 1135 QTGECKLVISMTFADDAGEYTIVVRNKHG 1163
Score = 61.2 bits (147), Expect = 4e-09
Identities = 48/186 (25%), Positives = 82/186 (44%), Gaps = 18/186 (9%)
Query: 205 VNVPPAISMP---QKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK---YI 258
+ + P++ P ++ + T +G + F R G P+P W++NG IE +++ Y
Sbjct: 2069 IELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYW 2128
Query: 259 LKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII---QLKNETTYE- 314
+ + EL +R++ D + +A N AGE AFL V + I +L++ E
Sbjct: 2129 PEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEK 2188
Query: 315 NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSD 374
+ T C+ EP ++ W + DG EGDK + L I + SD
Sbjct: 2189 DTMATFECET-SEPFVKVKWYK--DGMEVHEGDK-----YRMHSDRKVHFLSILTIDTSD 2240
Query: 375 SGRYDC 380
+ Y C
Sbjct: 2241 AEDYSC 2246
Score = 60.8 bits (146), Expect = 5e-09
Identities = 103/463 (22%), Positives = 180/463 (38%), Gaps = 55/463 (11%)
Query: 248 GKLIEENEK----YILKGSNTELT--VRNIINSDGGPYVCRATNKAGEDE-KQAFLQVFV 300
G L+E +K ++ G +LT V ++ + +A N AG E ++AF V +
Sbjct: 28579 GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVII 28638
Query: 301 QPHIIQLKNETTYENGQVTLVCDA----------EGEPIPEITWKRAVDGFTFTEGDKSL 350
+ I+ + T Q+ + C A G P P++TWK ++ E D
Sbjct: 28639 KEPQIEPTADLTGITNQL-ITCKAGSPFTIDVPISGRPAPKVTWK--LEEMRLKETD--- 28692
Query: 351 DGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP--------- 401
R+ + ++L +KD DSGRY + G S+ + + P
Sbjct: 28693 --RVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEV 28750
Query: 402 KFISNQTIYYSW----EGNPINI-SCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGR 456
+S ++ SW +G I + V+ + W +LV + T +K +
Sbjct: 28751 SSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAW---QLVNSSVKRTQIKVTHLTK 28807
Query: 457 KMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSF 516
M +S+N FG + I E+ PS+P ++ +S + +
Sbjct: 28808 YMEYSFRVSSENRFGVSKPLESAPI---IAEHPFV---PPSAPTRPEVYHVSANAMSIRW 28861
Query: 517 NKPDSHGGVPIHHYQVDVKEVASEIW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGK 575
+P GG I Y V+ KE + +W K + ++ + L Y+ R A+N
Sbjct: 28862 EEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAA 28921
Query: 576 GQGDYSKIE--IFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYR-- 631
G S+ I PV P P + S S S DGG+ ++ YI++ +
Sbjct: 28922 GVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAY-DGGSKVVGYIIERKPV 28980
Query: 632 SKDKEDQWLEKKVQGNKDHII-LEHLQWTMGYEVQITAANRLG 673
S+ + +WL+ D+ + L YE ++ A N G
Sbjct: 28981 SEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAG 29023
Score = 60.1 bits (144), Expect = 8e-09
Identities = 86/439 (19%), Positives = 171/439 (38%), Gaps = 55/439 (12%)
Query: 51 IDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLE 110
+ W+ GE+I+ + + ++ +G+R L I A+++D G Y C D +A V +E
Sbjct: 11692 VKWFK-DGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVC---DCGTDKTKANVTVE 11747
Query: 111 IYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNN 170
+ + + + E GE A + S P W + +T D +
Sbjct: 11748 A-RLIKVEKPLYGVEVFVGETAHFEIEL-SEPDVHGQWKLKGQPLTASPDCEIIEDGKKH 11805
Query: 171 LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSF---------NAT 221
+ IL + C+ + GE+ F+ N A ++ K +
Sbjct: 11806 ILIL---------HNCQ--LGMTGEVSFQ----AANAKSAANLKVKELPLIFITPLSDVK 11850
Query: 222 AERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKY--ILKGSNTELTVRNIINSDGGPY 279
+E F C S P+ W + + I ++++ I G+ + +++ D Y
Sbjct: 11851 VFEKDEAKFECEVSREPK-TFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKY 11909
Query: 280 VCRATNK--AGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRA 337
+ A +K +G+ + F+ P LK+ T E + + I + W +
Sbjct: 11910 MFEAEDKHTSGKLIIEGIRLKFLTP----LKDVTAKEKESAVFTVELSHDNI-RVKWFKN 11964
Query: 338 VDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI 397
T + ++ + + S+ KD+ + D+ + EA +G ++ +
Sbjct: 11965 DQRLHTTRS-------VSMQDEGKTHSITFKDLSIDDTSQIRVEA---MGMSSEAKLTVL 12014
Query: 398 EYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD-KLVLPAKNTTNLKTYSTGR 456
E P F Y E + + + C++ S A + W +D K + P+KN + G+
Sbjct: 12015 EGDPYFTGKLQDYTGVEKDEVILQCEI-SKADAPVKWFKDGKEIKPSKNAV---IKADGK 12070
Query: 457 KMILEIAPTSDNDFGRYNC 475
K +L + +D G+Y C
Sbjct: 12071 KRMLILKKALKSDIGQYTC 12089
Score = 59.7 bits (143), Expect = 1e-08
Identities = 93/420 (22%), Positives = 174/420 (41%), Gaps = 48/420 (11%)
Query: 283 ATNKAG-EDEKQAFLQVFV----QPHIIQLKN---ETTYENGQVTLVCDA--EGEPIPEI 332
A N+AG D ++ L V + +P I +KN T Y L D G+P+P++
Sbjct: 26449 AENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKV 26508
Query: 333 TWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKS 392
T R DG ++ E+ ++ ++++K+ +D+GRY+ AA+ G +
Sbjct: 26509 TLSR--DGVPLKA---TMRFNTEITAEN--LTINLKESVTADAGRYEITAANSSGTTKAF 26561
Query: 393 MYLDIEYAP---------KFISNQTIYYSWE------GNPINISCDVKSNPPASIHWRRD 437
+ + + P I+ +++ WE G+ + +K ++ W
Sbjct: 26562 INIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAV-WTEV 26620
Query: 438 KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPS 497
+ A+ + +TG + I ++N FG ++HI + L P
Sbjct: 26621 SATV-ARTMMKVMKLTTGEEYQFRI--KAENRFG-----ISDHIDSACVTVKLPYT-TPG 26671
Query: 498 SPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM-VVL 556
P + +++ + V +++P S+GG + Y +++K+ S +W+ ++T +
Sbjct: 26672 PPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKV 26731
Query: 557 NNLEPNTTYEIRVAAVNGKGQGDYS-KIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITK 615
+ YE RV A N G G S E + EP P ++ S S LS +
Sbjct: 26732 TTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEP-PRNVRITDISKNSVSLSWQQ 26790
Query: 616 QD-DGGAPILEYIVKYRSKDKEDQWLEKKVQG-NKDHIILEHLQWTMGYEVQITAANRLG 673
DGG+ I YIV+ R + +W + + I+ L YE ++ A N +G
Sbjct: 26791 PAFDGGSKITGYIVERRDL-PDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 26849
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/282 (24%), Positives = 117/282 (41%), Gaps = 31/282 (10%)
Query: 414 EGNPINISCDVKSNPPASIHW-----RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDN 468
EG +NI +K P ++ W ++ P T++ L I + +
Sbjct: 16130 EGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRS 16189
Query: 469 DFGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGVPI 527
D G Y TA N++GT +E L + P P G +K +S +S+ P GG I
Sbjct: 16190 DTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKI 16249
Query: 528 HHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGD--YSKIEI 585
+Y ++ +E + W V S + + L Y R+ A N G G+ S+ E
Sbjct: 16250 TNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPET 16309
Query: 586 FQTLPVREPSPPSIHGQPSSGKSFKLSIT-----KQDDGGAPILEYIVKYRSKDKEDQWL 640
+ L S P +P+ + S+T + DGG+P+ Y ++ + + +W
Sbjct: 16310 ARNL----FSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSK-RW- 16363
Query: 641 EKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEF 682
K+V N+D I T+G ++T G E + Y+F
Sbjct: 16364 -KRV--NRDPI----KAMTLGVSYKVT-----GLIEGSDYQF 16393
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/183 (25%), Positives = 74/183 (40%), Gaps = 14/183 (7%)
Query: 225 GEEMTFSCRASGSPEPAISWFRNGKLI--EENEKYILKGSNTE-LTVRNIINSDGGPYVC 281
G+ F + G P P WF +G+ I + K ++K T+ L + SD G +
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530
Query: 282 RATNKAGEDEKQAFLQVFVQPHIIQ------LKNETTYENGQVTLVCDAEGEPIPEITWK 335
A N+AG L V H ++ LKN E ++ + A G P P+I W
Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWL 1590
Query: 336 RAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYL 395
+ D + K I ++G G ++L I DS Y A ++ G +
Sbjct: 1591 KNSDIIVPHKYPK-----IRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKV 1645
Query: 396 DIE 398
++E
Sbjct: 1646 NVE 1648
Score = 58.2 bits (139), Expect = 3e-08
Identities = 73/342 (21%), Positives = 141/342 (41%), Gaps = 42/342 (12%)
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ---------LKNETTYENGQ- 317
V +I + + +A N GE E + + + I+ ++ T GQ
Sbjct: 17866 VPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQT 17925
Query: 318 VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGR 377
+ ++ +G P P+ITW + +G + R+++ L IK+ +D G+
Sbjct: 17926 IRILARVKGRPEPDITWTK--EGKVLVR-----EKRVDLIQDLPRVELQIKEAVRADHGK 17978
Query: 378 YDCEAASRIGGHQKSMYLDIEYAP--------KFISNQTIYYSWEGNPINISCDVKSNPP 429
Y A + G Q S +++ P ++ + SWE NP++ +N
Sbjct: 17979 YIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWE-NPLDNGGSEITN-- 18035
Query: 430 ASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT----RF 485
+ +R+ P + ++ S K +++ ++N++ + A N +G
Sbjct: 18036 FIVEYRK-----PNQKGWSI-VASDVTKRLIKANLLANNEY-YFRVCAENKVGVGPTIET 18088
Query: 486 QEYILAL--ADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWK 543
+ ILA+ D P P + I + +T + + +PD GG P Y V+ + S+ W+
Sbjct: 18089 KTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWE 18148
Query: 544 IVRSHGV-QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE 584
V + +T +++ N YE RV N G+ D+ K E
Sbjct: 18149 RVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTE 18190
Score = 57.8 bits (138), Expect = 4e-08
Identities = 94/447 (21%), Positives = 170/447 (38%), Gaps = 84/447 (18%)
Query: 173 ILNINKSDEGIYRCEGRVEARGEIDFRDIIVIV-----NVPPAISMPQKSFNATAERGEE 227
I + +E ++R V +G D R + V V + P++ +P +FN A E+
Sbjct: 25355 ISGLTAGEEYVFRVAA-VNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAR--EQ 25411
Query: 228 MTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSN--TELTVRNIINSDGGPYVCRATN 285
+ G P+ ++W ++G+ ++E + + S T L+++ D G Y +N
Sbjct: 25412 LKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSN 25471
Query: 286 KAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTE 345
AG P I +V D G P P + + D T +
Sbjct: 25472 SAGS---------ITVPITI--------------IVLDRPGPPGPIRIDEVSCDSITISW 25508
Query: 346 GDKSLDGRIEV------KGQHGSSSLH----------IKDVKLSDSGRYDCE--AASRIG 387
DG ++ K + S++ H IK V+L+ Y A +R G
Sbjct: 25509 NPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYG 25568
Query: 388 --GHQKSMYLDIEY---------APKFI--SNQTIYYSWEGNPIN------ISCDVKSNP 428
+ +S + EY PK + + T+ +W+ P+N I ++
Sbjct: 25569 KSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQ-VPVNDGGSRVIGYHLEYKE 25627
Query: 429 PASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCT-ATNHIGTRFQE 487
+SI W + +L A T +K ++ E ++N G C+ + + R
Sbjct: 25628 RSSILWSKANKILIA--DTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDP- 25684
Query: 488 YILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRS 547
D P P ++ +++ + + ++KP GG I Y V+ +E+ W
Sbjct: 25685 -----CDPPGQP---EVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNY 25736
Query: 548 HGVQ-TMVVLNNLEPNTTYEIRVAAVN 573
+Q T + L + YE RV A N
Sbjct: 25737 TNIQETYFEVTELTEDQRYEFRVFARN 25763
Score = 57.8 bits (138), Expect = 4e-08
Identities = 68/310 (21%), Positives = 107/310 (34%), Gaps = 54/310 (17%)
Query: 219 NATAERGEEMTFSCRASGSPEPA-ISWFRNGKLIEENEKYILKGSN--TELTVRNIINSD 275
+A E G + + C+ + ++W+ + +E +EKY + + L V++I D
Sbjct: 31576 HAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLD 31635
Query: 276 GGPYVCRATNKAGEDEKQAFL---------------------------QVFVQP--HIIQ 306
G Y C+ N GED A L ++ +P +
Sbjct: 31636 DGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLP 31695
Query: 307 LKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLH 366
L N+T Y V P P +TW ++ G GD D + + G L
Sbjct: 31696 LYNKTAYVGENVRFGVTITVHPEPHVTWYKS--GQKIKPGDN--DKKYTFESDKGLYQLT 31751
Query: 367 IKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP------------KFISNQTIYYSWE 414
I V D Y A ++ G L + P + ++N E
Sbjct: 31752 INSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQ---E 31808
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMI-LEIAPTSDNDFGRY 473
G + V PP ++ W +D P N++ G L I T D G Y
Sbjct: 31809 GQSVCFEIRVSGIPPPTLKWEKDGQ--PLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 31866
Query: 474 NCTATNHIGT 483
TATN G+
Sbjct: 31867 RVTATNTAGS 31876
Score = 57.4 bits (137), Expect = 5e-08
Identities = 48/195 (24%), Positives = 83/195 (42%), Gaps = 17/195 (8%)
Query: 120 VVSPQEFK--QGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANN--NLQILN 175
V+ P FK +G+ A +V P P W + +++ ++ + + +L I+
Sbjct: 1460 VLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVP 1519
Query: 176 INKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSF-----NATAERGEEMTF 230
SD G E V A+ I VI+ V + F N + G +
Sbjct: 1520 ATPSDSG----EWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEM 1575
Query: 231 SCRASGSPEPAISWFRNGKLIEENE--KYILKGSNTE--LTVRNIINSDGGPYVCRATNK 286
RA+G+P P I W +N +I ++ K ++G+ E L + + ++ D Y A NK
Sbjct: 1576 KVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINK 1635
Query: 287 AGEDEKQAFLQVFVQ 301
AG D + + V V+
Sbjct: 1636 AGRDTTRCKVNVEVE 1650
Score = 57.4 bits (137), Expect = 5e-08
Identities = 66/280 (23%), Positives = 110/280 (39%), Gaps = 40/280 (14%)
Query: 316 GQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDS 375
G + L +G P PE+ W + VDG + D I + +SL + +V DS
Sbjct: 22958 GSLRLFVPIKGRPTPEVKWGK-VDG-------EIRDAAI-IDVTSSFTSLVLDNVNRYDS 23008
Query: 376 GRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWR 435
G+Y + G KS ++ + P+N+ + SI W
Sbjct: 23009 GKYTLTLENSSG--TKSAFVTVR-----------VLDTPSPPVNLKVTEITKDSVSITWE 23055
Query: 436 --------RDKLVLPAKNTTNLKTY----STGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
+ K + K K+Y + K +I + + TA N G
Sbjct: 23056 PPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGI 23115
Query: 484 RFQEYI---LALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE 540
+ +A+VP P + + ++++ + +S+ KP+ GG I Y V+++ SE
Sbjct: 23116 GLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSE 23175
Query: 541 IW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGD 579
W + R +Q V+ NL Y RV AVN KG+ D
Sbjct: 23176 KWSECARVKSLQ--AVITNLTQGEEYLFRVVAVNEKGRSD 23213
Score = 57.4 bits (137), Expect = 5e-08
Identities = 66/290 (22%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 209 PAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT- 267
P I++ +S G+ F P + W+ NG ++E+ K ++ LT
Sbjct: 32374 PRITLRMRSHRVPC--GQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTL 32431
Query: 268 -VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEG 326
+ + D G Y TN GE A L V + TTY + + +
Sbjct: 32432 EILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDY-------TTYASQRRDE--EVPR 32482
Query: 327 EPIPEITWKR--AVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
PE+T AV F T ++ EVK Q + + + S S A
Sbjct: 32483 SVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALE 32542
Query: 385 RIGGHQKSMYLDIE--YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLP 442
+KS I+ A + ++ +EG SCD P ++ W R VL
Sbjct: 32543 EKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLS 32602
Query: 443 AKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILAL 492
+ T T K EI+ +D G Y+ N G + E+ L +
Sbjct: 32603 TSARHQVTT--TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTI 32650
Score = 56.6 bits (135), Expect = 9e-08
Identities = 123/582 (21%), Positives = 225/582 (38%), Gaps = 70/582 (12%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKII-STQRVVVQKEGVRSRLT 79
L + L V + F C E I W +G II S+ + + +G + L
Sbjct: 11486 LDFAVPLKDVTVPERRQARFECVLTREANVI-W--SKGPDIIKSSDKFDIIADGKKHILV 11542
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVS 139
I ++ +D G+Y + K T V I +L F + Q K+GE A VC +S
Sbjct: 11543 INDSQFDDEGVYTAEVEGKK--TSARLFVTGI--RLKFMSPLEDQTVKEGETATFVCELS 11598
Query: 140 SSPAPAVSWLYHNEEVTTISDNRFAMLAN----NNLQILNINKSDEGIYRCEGRVEARGE 195
V W ++ ++ T +R ++++ + L++ + D I + + +V+ E
Sbjct: 11599 HEKMHVV-WFKNDAKLHT---SRTVLISSEGKTHKLEMKEVTLDD--ISQIKAQVK---E 11649
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE 255
+ + ++ P ++ K + TA +E+T C S + + WF++G+ I +
Sbjct: 11650 LSSTAQLKVLEADPYFTV--KLHDKTAVEKDEITLKCEV--SKDVPVKWFKDGEEIVPSP 11705
Query: 256 KYILK--GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTY 313
KY +K G L ++ D G YVC G D+ +A V V+ +I+++
Sbjct: 11706 KYSIKADGLRRILKIKKADLKDKGEYVC----DCGTDKTKA--NVTVEARLIKVEKPLYG 11759
Query: 314 ENGQVTLVCDAE---GEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDV 370
V E EP WK T S D I G+ LH +
Sbjct: 11760 VEVFVGETAHFEIELSEPDVHGQWKLKGQPLT-----ASPDCEIIEDGKKHILILH--NC 11812
Query: 371 KLSDSGRYDCEAASRIGGHQKSMYLDIEYAPK-FISNQTIYYSWEGNPINISCDVKSNPP 429
+L +G +AA+ + + L ++ P FI+ + +E + C+V S P
Sbjct: 11813 QLGMTGEVSFQAANA----KSAANLKVKELPLIFITPLSDVKVFEKDEAKFECEV-SREP 11867
Query: 430 ASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE-- 487
+ W + + + L T M+++ A D + + G E
Sbjct: 11868 KTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGI 11927
Query: 488 ---YILALADVPS--SPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW 542
++ L DV + V +ELS +V + K D +H + V+
Sbjct: 11928 RLKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQR----LH----TTRSVS---- 11975
Query: 543 KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE 584
++ G + +L + T +IRV A+ + + +E
Sbjct: 11976 --MQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLE 12015
Score = 56.6 bits (135), Expect = 9e-08
Identities = 64/292 (21%), Positives = 115/292 (39%), Gaps = 31/292 (10%)
Query: 319 TLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRY 378
T+ G P+P + W + D L R V +SL I++ +DSG+Y
Sbjct: 26205 TMTVPFRGRPVPNVLWSKP---------DTDLRTRAYVDTTDSRTSLTIENANRNDSGKY 26255
Query: 379 DCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSN----PPASIHW 434
+ + ++ + + P +N T+ + + + +S DV N P + H
Sbjct: 26256 TLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAV-LSWDVPENDGGAPVKNYHI 26314
Query: 435 RR----DKLVLPAKNTTNLKTYSTGRKM---ILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
+ K + N N +Y I + +N+FG A G +
Sbjct: 26315 EKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFG-VGIPAETKEGVK--- 26370
Query: 488 YILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRS 547
+ + PS P + + +S+ + +++ KP+ GG I HY V+ E + W + +
Sbjct: 26371 ----ITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNW-VKCA 26425
Query: 548 HGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSI 599
T V++ L N+ Y RV A N G D ++ + L + PP I
Sbjct: 26426 VAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPREL-LLPVLIKEQLEPPEI 26476
Score = 55.8 bits (133), Expect = 2e-07
Identities = 47/218 (21%), Positives = 84/218 (38%), Gaps = 18/218 (8%)
Query: 113 QKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTT---------ISDNRF 163
Q TF + + +G A +S P P VSW + ++T SD R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR- 62
Query: 164 AMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAE 223
L I + K++ G Y + + +++V P + Q+ + T
Sbjct: 63 -----AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPP-NFVQRLQSMTVR 116
Query: 224 RGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYIL--KGSNTELTVRNIINSDGGPYVC 281
+G ++ R +G P P + ++R+G I+ + + + +G L + D G Y
Sbjct: 117 QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176
Query: 282 RATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVT 319
ATN G A L V + + K +T Q++
Sbjct: 177 NATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
Score = 55.8 bits (133), Expect = 2e-07
Identities = 79/345 (22%), Positives = 136/345 (39%), Gaps = 53/345 (15%)
Query: 264 TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQ------VFVQPHI---IQLKNETTYE 314
TE V N+ + A N AG+ E + + P I + L+ +
Sbjct: 27225 TEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAK 27284
Query: 315 NGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS 373
G+ V ++ +G P P +TW++ E + D R ++ SS L I V +
Sbjct: 27285 AGEDVQVLIPFKGRPPPTVTWRK-------DEKNLGSDARYSIENTDSSSLLTIPQVTRN 27337
Query: 374 DSGRYDCEAASRIGGHQKS----MYLDIEYA-----PKFISNQTIYYSWE------GNPI 418
D+G+Y + +G + S LD A K +S T+ W+ G+PI
Sbjct: 27338 DTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPI 27397
Query: 419 NISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFG-RYNCTA 477
I+ ++ W +V ++T+ K K ++N+ G C
Sbjct: 27398 -INYVIEKRDATKRTW---SVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCET 27453
Query: 478 TNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEV 537
T + A+VP+ + + + ++T+ +S+ KPD GG I Y V+ K
Sbjct: 27454 TEPV---------KAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGK 27504
Query: 538 ASEIWKIVRSH-GVQTM--VVLNNLEPNTTYEIRVAAVNGKGQGD 579
+ W SH G+ + ++ L+ + E RV A N KG D
Sbjct: 27505 GEQTW----SHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSD 27545
Score = 55.1 bits (131), Expect = 3e-07
Identities = 122/561 (21%), Positives = 200/561 (35%), Gaps = 63/561 (11%)
Query: 10 LGLLVSSGQALLQVTI--SLSKVELSVGESKFFTC-TAIGEPESIDWYNPQGEKIISTQR 66
LGL S ++ V + L V + G C ++ + S+ WY E+I R
Sbjct: 2432 LGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYL-NDEQIKPDDR 2490
Query: 67 VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEF 126
V +G + RL I + D G Y+ + + ++I + L ++
Sbjct: 2491 VQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIKIIRGL--------RDL 2542
Query: 127 KQGEDAEVVCRVSSSPAPA-VSWLYHNEEVTTISDNRFAMLAN-NNLQILNINKSDEGIY 184
E VV V S + V W + ++E+ S + L +LN+ K DEG Y
Sbjct: 2543 TCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKY 2602
Query: 185 RC-EGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS 243
G G++ AIS P + T +E F C + +P+
Sbjct: 2603 TFYAGENMTSGKLTVAG--------GAISKPLT--DQTVAESQEAVFECEVA-NPDSKGE 2651
Query: 244 WFRNGKLIE--ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ 301
W R+GK + N + G L + D G Y T K + A L+V
Sbjct: 2652 WLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEY----TYKVATSKTSAKLKVEAV 2707
Query: 302 PHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHG 361
LKN T E + + + W + +G +K I VKG
Sbjct: 2708 KIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIK--NGVVLESNEKYA---ISVKGT-- 2760
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
SL IK+ + D Y R+G S L +E K I + E +
Sbjct: 2761 IYSLRIKNCAIVDESVY----GFRLGRLGASARLHVETV-KIIKKPKDVTALENATVAFE 2815
Query: 422 CDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILE-IAPTSDNDF----GRYNCT 476
V S+ + W + + + L + K++L+ I+P+ ++ G+ C
Sbjct: 2816 VSV-SHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECK 2874
Query: 477 ATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKE 536
A + T + +VP T SF SH VP + V+
Sbjct: 2875 AKLFVETLHITKTMKNIEVPE-------------TKTASFECEVSHFNVPSMWLKNGVEI 2921
Query: 537 VASEIWKIVRSHGVQTMVVLN 557
SE +KIV + ++++N
Sbjct: 2922 EMSEKFKIVVQGKLHQLIIMN 2942
Score = 55.1 bits (131), Expect = 3e-07
Identities = 80/379 (21%), Positives = 158/379 (41%), Gaps = 45/379 (11%)
Query: 17 GQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRS 76
G+ +++ + V + ES F I E + + +GE + + ++ EG +
Sbjct: 11393 GEREVELLKPIEDVTIYEKESASFDAE-ISEADIPGQWKLKGELLRPSPTCEIKAEGGKR 11451
Query: 77 RLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVC 136
LT++ ++ AG QA +A +E+ + ++V P E +Q V+
Sbjct: 11452 FLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVP-ERRQARFECVLT 11510
Query: 137 RVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKS---DEGIYRCE---GRV 190
R ++ V W + + S ++F ++A+ IL IN S DEG+Y E +
Sbjct: 11511 REAN-----VIWSKGPDIIK--SSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKT 11563
Query: 191 EARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKL 250
AR + + + P + + T + GE TF C S + + WF+N
Sbjct: 11564 SAR--------LFVTGIRLKFMSPLE--DQTVKEGETATFVCELS-HEKMHVVWFKNDAK 11612
Query: 251 IEENEKYIL--KGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVF-VQPHI-IQ 306
+ + ++ +G +L ++ + D + + + E A L+V P+ ++
Sbjct: 11613 LHTSRTVLISSEGKTHKLEMKEVTLDD----ISQIKAQVKELSSTAQLKVLEADPYFTVK 11668
Query: 307 LKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDG-RIEVKGQHGSSSL 365
L ++T E ++TL C+ + +P + W F +G++ + + +K L
Sbjct: 11669 LHDKTAVEKDEITLKCEV-SKDVP-VKW--------FKDGEEIVPSPKYSIKADGLRRIL 11718
Query: 366 HIKDVKLSDSGRYDCEAAS 384
IK L D G Y C+ +
Sbjct: 11719 KIKKADLKDKGEYVCDCGT 11737
Score = 54.7 bits (130), Expect = 4e-07
Identities = 113/534 (21%), Positives = 208/534 (38%), Gaps = 70/534 (13%)
Query: 6 SFYLLGLLVSSGQALLQVTISLSKVELSVGESK--FFTCTAIGEPESIDWYNPQGEKIIS 63
+FY + S + IS + +V ES+ F C + P+S + G+ +
Sbjct: 2603 TFYAGENMTSGKLTVAGGAISKPLTDQTVAESQEAVFECE-VANPDSKGEWLRDGKHLPL 2661
Query: 64 TQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQ---EATVVLEIYQKLTFREV 120
T + + +G + RL I ++D G Y + +K + EA + + + LT E
Sbjct: 2662 TNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTET 2721
Query: 121 VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANN---NLQILNIN 177
+DA ++ V W+ + V S+ ++A+ +L+I N
Sbjct: 2722 ---------QDAVFTVELTHPNVKGVQWIKNG--VVLESNEKYAISVKGTIYSLRIKNCA 2770
Query: 178 KSDEGIYRCE-GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASG 236
DE +Y GR+ A + + +I +K + TA + F S
Sbjct: 2771 IVDESVYGFRLGRLGASARLHVETVKII----------KKPKDVTALENATVAFEVSVSH 2820
Query: 237 SPEPAISWFRNGKLIEENEKYILKGSNT--ELTVRNIINSDGGPYVCRATNKAGEDEKQA 294
P + WF I+ ++K+ L +L ++NI SD G Y T G+ E +A
Sbjct: 2821 DTVP-VKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEY----TAVVGQLECKA 2875
Query: 295 FLQVFVQP-HIIQ-LKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDG 352
++FV+ HI + +KN E + C+ +P + K V E + S
Sbjct: 2876 --KLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSMWLKNGV------EIEMSEKF 2927
Query: 353 RIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYS 412
+I V+G+ L I + DS Y G Q S L + P I++ +
Sbjct: 2928 KIVVQGK--LHQLIIMNTSTEDSAEYTFVC----GNDQVSATLTV--TPIMITSMLKDIN 2979
Query: 413 WEGNPINISCDVKSN-PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMIL---EIAPTSDN 468
E I+ +V N S W ++ + + + + ++T + + +D
Sbjct: 2980 AEEKD-TITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADY 3038
Query: 469 DF--GRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPD 520
F G+ TAT ++ R E+ + D +K++E + + ++PD
Sbjct: 3039 TFVAGKATSTATLYVEARHIEFRKHIKD-------IKVLEKKRAMFECEVSEPD 3085
Score = 53.5 bits (127), Expect = 8e-07
Identities = 58/270 (21%), Positives = 109/270 (40%), Gaps = 42/270 (15%)
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
+G P PE+TW T+ + +L R ++ + L I + D+G++ +
Sbjct: 20801 KGRPAPEVTW---------TKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIEN 20851
Query: 385 RIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHW--------RR 436
G +KS ++++ G +N+ + ++HW R
Sbjct: 20852 PAG--KKSGFVNVRVLDT-----------PGPVLNLRPTDITKDSVTLHWDLPLIDGGSR 20898
Query: 437 DKLVLPAKNTTNLKTYSTG----RKMILEIAPTSDNDFGRYNCTATNHIG----TRFQEY 488
+ K K+YST K ++ S+ + A N G T E
Sbjct: 20899 ITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEP 20958
Query: 489 ILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW-KIVRS 547
+ A ++ PS P + I++++++T +++ KP GG I Y ++ + S+ W I
Sbjct: 20959 VKA-SEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV 21017
Query: 548 HGVQTMVVLNNLEPNTTYEIRVAAVNGKGQ 577
G++ V+ NL Y +V AVN G+
Sbjct: 21018 KGLE--CVVRNLTEGEEYTFQVMAVNSAGR 21045
Score = 52.8 bits (125), Expect = 1e-06
Identities = 77/371 (20%), Positives = 136/371 (36%), Gaps = 50/371 (13%)
Query: 236 GSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
G P P W + G+ I + ++TEL ++ D G Y NK G +K +
Sbjct: 30162 GKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCG--KKAVY 30219
Query: 296 LQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVD-------GFTFTEGDK 348
++V V + Y++ QV V ++W+ D G+ +
Sbjct: 30220 IKVRVIGSPNSPEGPLEYDDIQVRSV---------RVSWRPPADDGGADILGYILERREV 30270
Query: 349 SLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQT 408
+ + +SL +K +K + + A ++ G K + + PK N
Sbjct: 30271 PKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQF-GISKPLKSEEPVTPKTPLNPP 30329
Query: 409 IYYSWEGNPINISCDVKSNPPASIHWRRDK---------LVLPAKNTT-------NLKTY 452
NP + KS+ S+ W R K + K T+ N
Sbjct: 30330 ---EPPSNPPEVLDVTKSS--VSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQI 30384
Query: 453 STGRKMILEIAPTSDNDFGRYNCTATNHIG----TRFQEYILAL--ADVPSSPYGVKIIE 506
+T + + P ++ F A N +G + E ++ D PS P ++I+
Sbjct: 30385 TTTMYTVTGLVPDAEYQF---RIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILS 30441
Query: 507 LSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQ-TMVVLNNLEPNTTY 565
+S+ + + + KP+ GG I Y V+ ++ WK ++ + L T Y
Sbjct: 30442 ISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEY 30501
Query: 566 EIRVAAVNGKG 576
E RV A N G
Sbjct: 30502 EFRVFAENETG 30512
Score = 52.4 bits (124), Expect = 2e-06
Identities = 68/333 (20%), Positives = 124/333 (37%), Gaps = 62/333 (18%)
Query: 35 GESKFFTCTAIGEPESIDWYNPQGEKIIS--TQRVVVQKEGVRSRLTIYNANIEDAGIYR 92
G++ F +G P ++ G++I++ T +VV++++G +S L I A D+G +
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQS-LIIVPATPSDSGEWT 1529
Query: 93 CQATDAKGQTQEATVV----LEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSW 148
A + G++ + ++ +E K F E + K+G E+ R + +P P + W
Sbjct: 1530 VVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVW 1589
Query: 149 LYHNEEVTTISDNRFAMLANNNLQILN----------------INKSDEGIYRCEGRVEA 192
L +++ + + + L INK+ RC+ VE
Sbjct: 1590 LKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEV 1649
Query: 193 --------------RGEIDFRDIIVIVNVPPAISMPQKSF-------------------- 218
RG ++I P + Q+ +
Sbjct: 1650 EFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKL 1709
Query: 219 -NATAERGEEMTFSCRAS--GSPEPAISWFRNGKLIE--ENEKYILKGSNTELTVRNIIN 273
+ +R F CR + G P + W +GK +E + I + L +
Sbjct: 1710 TSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYS 1769
Query: 274 SDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ 306
D G CRATNK G D A L V + +++
Sbjct: 1770 RDSGIITCRATNKYGTDHTSATLIVKDEKSLVE 1802
Score = 52.4 bits (124), Expect = 2e-06
Identities = 103/467 (22%), Positives = 170/467 (36%), Gaps = 90/467 (19%)
Query: 207 VPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGS--NT 264
+PPA + +F A GE++ G P PA++W ++ +++ + + + N+
Sbjct: 22146 IPPAFKLLFNTFTVLA--GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNS 22203
Query: 265 ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDA 324
LT+++ D G YV + TN AGE I+ N +V D
Sbjct: 22204 LLTIKDACREDVGHYVVKLTNSAGE--------------AIETLN---------VIVLDK 22240
Query: 325 EGEPIPEITWKR-AVDGFTFT------EGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSG- 376
G P + D T + +G S++ I K +++ I ++ +
Sbjct: 22241 PGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTI 22300
Query: 377 -----RYDCEAASRIGG---HQKSMYLDIE-----YAPK-----------FISNQTIYYS 412
+ CE RI + KS YL+ E Y K S ++
Sbjct: 22301 KACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQ 22360
Query: 413 W-----EGNPINISCDVKSNPPASIHW-RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTS 466
W +G I ++ SI W + +K +P T KT + E ++
Sbjct: 22361 WNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIP---QTKFKTTGLEEGVEYEFRVSA 22417
Query: 467 DNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG-VKIIELSQTTAKVSFNKPDSHGGV 525
+N G IG + +A P P G + I +++ + + + KP GG
Sbjct: 22418 ENIVG---------IGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGS 22468
Query: 526 PIHHYQVDVKEVASEIW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIE 584
I Y V+ KE+ W K ++ + T + L + YE RV A N G
Sbjct: 22469 KITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSES 22528
Query: 585 IFQTLPVREPSPPSIHGQPS--------SGKSFKLSITKQDDGGAPI 623
E PP I P +G+SFK+ D G PI
Sbjct: 22529 TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVD---ADIYGKPI 22572
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/275 (21%), Positives = 101/275 (36%), Gaps = 35/275 (12%)
Query: 119 EVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNN---LQILN 175
E + Q QG DA RV P P W Y N SD + +N L I +
Sbjct: 2082 ERIQSQTVGQGSDAHFRVRVVGKPDPECEW-YKNGVKIERSDRIYWYWPEDNVCELVIRD 2140
Query: 176 INKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEM-TFSCRA 234
+ D + + GE + +V I+ Q+ + A+ + M TF C
Sbjct: 2141 VTAEDSASIMVKA-INIAGETSSHAFL-LVQAKQLITFTQELQDVVAKEKDTMATFECET 2198
Query: 235 SGSPEPAISWFRNGKLIEENEKYILKGSNTE--LTVRNIINSDGGPYVCRATNKAGEDEK 292
S P + W+++G + E +KY + L++ I SD Y C
Sbjct: 2199 S-EPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSC----------- 2246
Query: 293 QAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPE--------ITWKRAVDG-FTF 343
V V+ ++ + E V V + + +PE I ++G +
Sbjct: 2247 -----VLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYH 2301
Query: 344 TEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRY 378
+ + +G+ + + G +L +KDV D G Y
Sbjct: 2302 NDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEY 2336
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/89 (30%), Positives = 49/89 (55%), Gaps = 1/89 (1%)
Query: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHG-VQTMV 554
P P VK+ + S+TT + ++KP GG+ I Y +++ + W V + V+T
Sbjct: 28254 PGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRY 28313
Query: 555 VLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
+ +L+ Y+ RV+A+NG G+GD ++
Sbjct: 28314 TVTDLQAGEEYKFRVSAINGAGKGDSCEV 28342
Score = 51.2 bits (121), Expect = 4e-06
Identities = 101/499 (20%), Positives = 168/499 (33%), Gaps = 74/499 (14%)
Query: 31 ELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQ--KEGVRSRLTIYNANIEDA 88
+L G S F C G P+ ++ G + + R V K+ +L I +DA
Sbjct: 1092 KLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDA 1151
Query: 89 GIYRCQATDAKGQTQEATVVLE---------IYQKLTFREVVSP--QEFKQGEDA----- 132
G Y + G+T + +LE Q++ ++ V+ QE K GE A
Sbjct: 1152 GEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVY 1211
Query: 133 ----------EVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEG 182
+ + R + V Y ++ IS ++ +I+
Sbjct: 1212 SEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTT----- 1266
Query: 183 IYRCEGRVEARGEIDFRDIIVIVNVPPAIS--MPQKSFNATAERGEEMTFSCRASGSPEP 240
E +E GE + V ++ A+ + N G +TF C+ SG P P
Sbjct: 1267 ---LEELLEEDGE---EKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLP 1320
Query: 241 AISWFRNGKLIEENEKY---ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQ 297
I+W+++GK I+ E+Y L+ L + ++ D G Y A+N G L
Sbjct: 1321 KIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLY 1380
Query: 298 VFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVK 357
V E G T + EP+ I +SL R +
Sbjct: 1381 V-----------EPAAPLGAPTYIPTL--EPVSRI---------------RSLSPRSVSR 1412
Query: 358 GQHGSSSLHIKDVKLSDSGRYDCE-AASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGN 416
S + ++S + + R L+ Y P F+ + EG
Sbjct: 1413 SPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQ 1472
Query: 417 PINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCT 476
V P W D + T + G + ++ I P + +D G +
Sbjct: 1473 TARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI-IVPATPSDSGEWTVV 1531
Query: 477 ATNHIGTRFQEYILALADV 495
A N G IL + V
Sbjct: 1532 AQNRAGRSSISVILTVEAV 1550
Score = 50.8 bits (120), Expect = 5e-06
Identities = 98/460 (21%), Positives = 176/460 (38%), Gaps = 59/460 (12%)
Query: 46 GEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQE 104
G+P ++ W + ++ RV + ++G ++L I + D+G+YRC A + G+ E
Sbjct: 8479 GDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEI-E 8537
Query: 105 ATVVLEIYQKLTFREVVSPQEFK----------QGEDAEV-VCRVSSSPAPAVSWLYHNE 153
+ V L++ ++ ++ GE+ E+ + + + P Y
Sbjct: 8538 SNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKY--A 8595
Query: 154 EVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNV------ 207
+ I+D R + A L+ +E +R E R E D ++ +V+
Sbjct: 8596 RMYGITDFRGLLQAFELLK----QSQEEETHRLEIEEIERSERDEKEFEELVSFIQQRLS 8651
Query: 208 -PPAISMPQKSFNATAERGEEMTFSCRAS-GSPEPAISWFRNGKLIEENEKYILK--GSN 263
+++ + N T + + F PE +SW++ + +E ++K+ + G
Sbjct: 8652 QTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDR 8711
Query: 264 TELTVRNIINSDGGPY--VCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLV 321
L V+N D G Y VC G A L V L++ T E T+
Sbjct: 8712 HTLRVKNCQLKDQGNYRLVC------GPHIASAKLTVIEPAWERHLQDVTLKEGQTCTMT 8765
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 381
C +P + + +G GR + + +H L I DV+ D G+Y C+
Sbjct: 8766 CQFS---VPNVKSEWFRNGRILKP-----QGRHKTEVEHKVHKLTIADVRAEDQGQYTCK 8817
Query: 382 AASRIGGHQKSMYLDIEYAP----KFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD 437
+ S L IE P K I N + E C+V S A + W +
Sbjct: 8818 YEDL----ETSAELRIEAEPIQFTKRIQNIVVS---EHQSATFECEV-SFDDAIVTWYKG 8869
Query: 438 KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTA 477
L N + + GR + I + +D G Y+ A
Sbjct: 8870 PTELTESQKYNFR--NDGRCHYMTIHNVTPDDEGVYSVIA 8907
Score = 50.8 bits (120), Expect = 5e-06
Identities = 91/406 (22%), Positives = 147/406 (36%), Gaps = 55/406 (13%)
Query: 207 VPPAISMPQKSFNA-TAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSN-- 263
VPP++ + K + G + F G P P W +G I+ +E Y ++ N
Sbjct: 17506 VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFS 17565
Query: 264 TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP-------HIIQLKNETTYENG 316
+ LT++N + D G Y +N AG L V P +I+ + E +
Sbjct: 17566 SVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISW 17625
Query: 317 QVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKG--QHGSSSLHIKDVKLSD 374
Q D G P+ ++ D R + G GSS +K L
Sbjct: 17626 QPPK--DDGGSPVINYIVEKQ-------------DTRKDTWGVVSSGSSKTKLKIPHLQK 17670
Query: 375 SGRYDCEAASRIGGHQK-SMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIH 433
CE R+ K + ++ P ++ S G P + D+ N A++
Sbjct: 17671 G----CEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKP--VVTDITEN-AATVS 17723
Query: 434 WRRDKL--VLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR-FQEYIL 490
W K P + TG+ + + P +D F N R F E +
Sbjct: 17724 WTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLA 17783
Query: 491 ALA-DVPSS--------------PYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVK 535
L+ PSS P K+ + S+ TA + + KP S GG PI Y V+ +
Sbjct: 17784 GLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQ 17843
Query: 536 EVASEIWKIVRSHGV--QTMVVLNNLEPNTTYEIRVAAVNGKGQGD 579
+ + W + + Q + L Y R+ A N G+G+
Sbjct: 17844 KPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 17889
Score = 50.8 bits (120), Expect = 5e-06
Identities = 41/175 (23%), Positives = 70/175 (40%), Gaps = 22/175 (12%)
Query: 138 VSSSPAPAVSWLYHNEEVTTISDNRF---AMLANNNLQILNINKSDEGIY----RCEGRV 190
V P W+ T I D F ++ ++ + I ++ G++ G +
Sbjct: 22475 VEKKELPEGRWM--KASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAI 22532
Query: 191 EARGEIDFRDIIVIVNVPPAISM-PQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGK 249
AR E+D PP ISM P+ GE G P P I W + +
Sbjct: 22533 TARDEVD----------PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 22582
Query: 250 LIEENEKYILKGSN--TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
+ + +K ++ T L+V++ + D G Y+ +A N AGE ++V +P
Sbjct: 22583 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637
Score = 50.1 bits (118), Expect = 9e-06
Identities = 59/282 (20%), Positives = 114/282 (40%), Gaps = 39/282 (13%)
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI--EVKGQHGSSSLHIKDVKLSDSGR 377
L +G P P+ITW + + +L RI ++K + L ++V D+G+
Sbjct: 19713 LYVPVKGRPPPKITWSKP---------NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGK 19763
Query: 378 YDCEAASRIGGHQKSMYLDIEYAP--------KFISNQTIYYSWE------GNPINISCD 423
Y + G + ++ + + P K IS + Y +WE G+PI I+
Sbjct: 19764 YILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPI-INYV 19822
Query: 424 VKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
V+ W +K + + G+ + ++N++G + T
Sbjct: 19823 VQKRDAERKSWSTVTTEC-SKTSFRVANLEEGKSYFFRV--FAENEYGIGDPGETRD--- 19876
Query: 484 RFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWK 543
+ + P +K+ +S+++ + + KP S GG I Y VD ++ +
Sbjct: 19877 -----AVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQR 19931
Query: 544 IVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI 585
+++S +Q +L Y RV+A N G+G S+I +
Sbjct: 19932 VMKSLSLQYSA--KDLTEGKEYTFRVSAENENGEGTPSEITV 19971
Score = 49.3 bits (116), Expect = 1e-05
Identities = 84/436 (19%), Positives = 172/436 (39%), Gaps = 55/436 (12%)
Query: 173 ILNINKSDEGIYRC-----EGRVEARG---EIDFRDIIVIVNVPPAISMPQKSFNATAER 224
I N+ + +E ++R +GR + R I +D+++ +V PA S + + +
Sbjct: 23190 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFS------SYSVQV 23243
Query: 225 GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGS--NTELTVRNIINSDGGPYVCR 282
G+++ SG P+P I+W ++G +++ + + S T L+++ DGG Y
Sbjct: 23244 GQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGIT 23303
Query: 283 ATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFT 342
N G +K A +++ K +++ + + P+ T + +
Sbjct: 23304 VANVVG--QKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPL--YTGGCQITNYI 23359
Query: 343 FTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGH--QKSMYLDIEYA 400
+ D + V ++L + +K ++ A +R G +S + +Y
Sbjct: 23360 VQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYP 23419
Query: 401 PK-----------FISNQTIYYSWE------GNPINISCDVKSNPPASIHWRR-DKLVLP 442
K IS ++ W G+P+ I ++ SI W + +K ++
Sbjct: 23420 YKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPV-IGYHLERKERNSILWTKVNKTII- 23477
Query: 443 AKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGV 502
+ T K + + E ++N G +G + +A P P G
Sbjct: 23478 --HDTQFKAQNLEEGIEYEFRVYAENIVG---------VGKASKNSECYVARDPCDPPGT 23526
Query: 503 -KIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW-KIVRSHGVQTMVVLNNLE 560
+ I + + + + KP GG I Y V+ +++ W K ++ ++T ++ L
Sbjct: 23527 PEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLT 23586
Query: 561 PNTTYEIRVAAVNGKG 576
+ YE RV A N G
Sbjct: 23587 EDQRYEFRVIAKNAAG 23602
Score = 48.5 bits (114), Expect = 3e-05
Identities = 45/187 (24%), Positives = 78/187 (41%), Gaps = 14/187 (7%)
Query: 299 FVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKG 358
F QP L++ E T G P+PE++W R DG + +L G +++
Sbjct: 8 FTQP----LQSVVVLEGSTATFEAHISGFPVPEVSWFR--DGQVISTS--TLPG-VQISF 58
Query: 359 QHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYA---PKFISNQTIYYSWEG 415
G + L I V ++SGRY +A + G + L ++ P F+ +G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 416 NPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNC 475
+ + + V P + + RD + +++ + + G L IA D G Y+
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEI--QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176
Query: 476 TATNHIG 482
ATN +G
Sbjct: 177 NATNSVG 183
Score = 47.8 bits (112), Expect = 4e-05
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 26/260 (10%)
Query: 225 GEEMTFSCRASGSPEPAIS-WFRNGKLIEENEK--YILKGSNTELTVRNIINSDGGPYVC 281
G F C S P AI+ W ++G I E+ K +I G + +L + ++ SD G Y C
Sbjct: 11133 GSSAIFECLVS--PSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTC 11190
Query: 282 --RATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAV 338
R NK + ++ + L+ E T GQ + L C+ E ++ W++
Sbjct: 11191 VLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELNKE--RDVVWRK-- 11246
Query: 339 DGFTFTEGDKSLDGRIEVKGQHG-SSSLHIKDVKLSDSGRY--DCEAASRIGGHQKSMYL 395
DG E GRI V G G +L I D +D+G Y E A+ + +
Sbjct: 11247 DGKIVVE----KPGRI-VPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVV 11301
Query: 396 DI--EYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYS 453
++ ++ K I +Q + +G I +CD+ + P +I W + +PA+ +
Sbjct: 11302 EVIRDWLVKPIRDQ--HVKPKGTAI-FACDIAKDTP-NIKWFKGYDEIPAEPNDKTEILR 11357
Query: 454 TGRKMILEIAPTSDNDFGRY 473
G + L+I D Y
Sbjct: 11358 DGNHLYLKIKNAMPEDIAEY 11377
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/102 (31%), Positives = 44/102 (43%)
Query: 495 VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMV 554
+PS P KI++ +TT +++ KP GG PI Y V+ K+ WK T
Sbjct: 26083 LPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEY 26142
Query: 555 VLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSP 596
++ L Y RV +VN G D S Q RE P
Sbjct: 26143 TISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEP 26184
Score = 47.4 bits (111), Expect = 6e-05
Identities = 57/279 (20%), Positives = 111/279 (39%), Gaps = 44/279 (15%)
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
+G P PE+ W R + +SLD + ++ + L + +V DSG+Y +
Sbjct: 21885 KGRPAPEVKWAR--------DHGESLD-KASIESTSSYTLLIVGNVNRFDSGKYILTVEN 21935
Query: 385 RIGGHQKSMYLDI----------EYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHW 434
G KS ++++ + K ++ ++ +W+ PP
Sbjct: 21936 SSG--SKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWD-------------PPLLDGG 21980
Query: 435 RRDKLVLPAKNTTNLKTYST----GRKMILEIAPTSDNDFGRYNCTATNHIG----TRFQ 486
+ K + K + K YST K ++ + + A N G
Sbjct: 21981 SKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETA 22040
Query: 487 EYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVR 546
E + A ++ P P + ++++++ + +S+ KP+ GG I Y V+++ S+ W
Sbjct: 22041 ESVKA-SERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCA 22099
Query: 547 SHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI 585
+ V T + L Y RV+A N KG D ++ +
Sbjct: 22100 TVKV-TEATITGLIQGEEYSFRVSAQNEKGISDPRQLSV 22137
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/101 (27%), Positives = 51/101 (50%), Gaps = 4/101 (3%)
Query: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM-- 553
PS P + + + + +++ P+ +GG PI Y V++ V +E W V S ++ +
Sbjct: 14285 PSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKF 14344
Query: 554 VVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP 594
V + P+ Y +RV AVN G + S EI + + ++P
Sbjct: 14345 KVEEGVVPDKEYVLRVRAVNAIGVSEPS--EISENVVAKDP 14383
Score = 46.6 bits (109), Expect = 1e-04
Identities = 84/381 (22%), Positives = 140/381 (36%), Gaps = 64/381 (16%)
Query: 236 GSPEPAISWFRNGKLIEENEKYILKGSNTE--LTVRNIINSDGGPYVCRATNKAG---ED 290
G P P SW + GK I ++ + + T LT++ D G Y ATN G E
Sbjct: 20405 GKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH 20464
Query: 291 EKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAE--GEPIPE-ITWKRAVDGFTFTEGD 347
K L V P +++ N + E +T E G PI I KR +T
Sbjct: 20465 VKVTVLDVPGPPGPVEISNVSA-EKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT--- 20520
Query: 348 KSLDGRIEVKGQHGSSSLHIKDVKLSDSGRY--DCEAASRIGGHQKSMYLDIEYAPKF-- 403
V + S H+ KL Y A + G + ++ +F
Sbjct: 20521 --------VVSEDIQSCRHVA-TKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGP 20571
Query: 404 -----------ISNQTIYYSW-----EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTT 447
++ T SW +G V+ S+ W R + P +
Sbjct: 20572 PGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVR-AIKTPV---S 20627
Query: 448 NLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG----TRFQEYILA--LADVPSSPYG 501
+L+ TG + + + +A N G + + +L A P P
Sbjct: 20628 DLRCKVTGLQ---------EGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSN 20678
Query: 502 VKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQ---TMVVLNN 558
+ + ++ +A +++ KP GG+ I Y V+ ++V E W I + G T V+ +
Sbjct: 20679 PHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAW-IKDTTGTALRITQFVVPD 20737
Query: 559 LEPNTTYEIRVAAVNGKGQGD 579
L+ Y R++A+N G G+
Sbjct: 20738 LQTKEKYNFRISAINDAGVGE 20758
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/86 (27%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHG--VQTM 553
P P ++++ S+++ +++NKP GG I Y V++ + W+IV T
Sbjct: 21756 PGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS 21815
Query: 554 VVLNNLEPNTTYEIRVAAVNGKGQGD 579
+ L N Y+IR+ A+N +G G+
Sbjct: 21816 YTITGLTENQEYKIRIYAMNSEGLGE 21841
Score = 46.2 bits (108), Expect = 1e-04
Identities = 40/165 (24%), Positives = 66/165 (40%), Gaps = 17/165 (10%)
Query: 326 GEPIPEITWKRAVDGFTFTEGDKSLDG---RIEVKGQHGSSSLHIKDVKLSDSGRYDCEA 382
G P+PE W F +G + ++ ++ +K + G+ SL I SDSG + A
Sbjct: 1482 GRPMPETFW--------FHDGQQIVNDYTHKVVIK-EDGTQSLIIVPATPSDSGEWTVVA 1532
Query: 383 ASRIGGHQKSMYLDIEYA-----PKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD 437
+R G S+ L +E P F+ EG+ + + NP I W ++
Sbjct: 1533 QNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKN 1592
Query: 438 KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
++ ++ T + L+I T D Y TA N G
Sbjct: 1593 SDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAG 1637
Score = 46.2 bits (108), Expect = 1e-04
Identities = 108/527 (20%), Positives = 196/527 (37%), Gaps = 85/527 (16%)
Query: 223 ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCR 282
+RG+E+ SGSP P I+W ++ +I E I K + + R + P+V
Sbjct: 14692 KRGDEIALDASISGSPYPTITWIKDENVIVPEE--IKKRAAPLVRRRKGEVQEEEPFVLP 14749
Query: 283 ATNKAGED-----EKQAFLQVFVQP----HIIQLKNETTYENGQVTL-VCDAEGEPIPEI 332
T + D E Q ++ ++P ++I+++N+ T+ V D G PI +
Sbjct: 14750 LTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFV 14809
Query: 333 -----------TWKRAVD-------GFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSD 374
W+ +D +T + DK+ + KL +
Sbjct: 14810 FEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIE 14869
Query: 375 SGRY--DCEAASRIGGH----QKSMYLDIEYAP---------KFISNQTIYYSWE----- 414
Y A +R G K + + P + +++ ++ W
Sbjct: 14870 GKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDN 14929
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G+PI + ++ S HW R L N+ G + + + G+++
Sbjct: 14930 GSPI-LGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFS 14988
Query: 475 CTATNHIGTRFQEYILALADVPSSPYGV---KIIELSQTTAKVSFNKPDSHGGVPIHHYQ 531
+ A P SP G ++ + S TT ++ + P +GG I Y
Sbjct: 14989 PPSDPKT-----------AHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYF 15037
Query: 532 VDVKEVASEIWKIVRSHGVQT-MVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLP 590
VD + V + W ++ + + Y++RV+AVN G+G + Q +
Sbjct: 15038 VDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGET---QPVT 15094
Query: 591 VREPSPP-------SIHG--QPSSGKSFKLSITKQDDGGAPILEYI-VKYRSKDKEDQWL 640
V EP P S+ G Q +GK+ ++ G P+ + K + +D+ +
Sbjct: 15095 VAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVT---GRPVPTKVWTKEEGELDKDRVV 15151
Query: 641 EKKVQGNKDHIILEHLQWTMGYEVQITAANRLG--YSEPTVYEFSMP 685
V + II + L+ G V ITA N G ++ V F +P
Sbjct: 15152 IDNVGTKSELIIKDALRKDHGRYV-ITATNSCGSKFAAARVEVFDVP 15197
Score = 45.8 bits (107), Expect = 2e-04
Identities = 69/272 (25%), Positives = 102/272 (37%), Gaps = 59/272 (21%)
Query: 47 EPESIDWYNPQGEKIISTQ-RVVVQKEGVRSRLTIYNANIEDAGIYRCQAT--------- 96
E SI W I TQ +V EG+ +Y NI AGI +C +
Sbjct: 25627 ERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENI--AGIGKCSKSCEPVPARDP 25684
Query: 97 -DAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCR---VSSSPAPAVSWLYHN 152
D GQ + + R+ VS + K D V P WL N
Sbjct: 25685 CDPPGQPEVTNIT---------RKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCN 25735
Query: 153 E--------EVTTISDNR---FAMLANNNLQILNINKSDEGIYRCEGRVE---ARGEIDF 198
EVT +++++ F + A N ++ G + VE ++ F
Sbjct: 25736 YTNIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKF 25795
Query: 199 RDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK-- 256
RD+IV+ + GE + + +G P P ISW ++G IEE +
Sbjct: 25796 RDVIVV------------------KAGEVLKINADIAGRPLPVISWAKDGIEIEERARTE 25837
Query: 257 YILKGSNTELTVRNIINSDGGPYVCRATNKAG 288
I ++T LTV++ I D G YV N AG
Sbjct: 25838 IISTDNHTLLTVKDCIRRDTGQYVLTLKNVAG 25869
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/273 (21%), Positives = 108/273 (39%), Gaps = 29/273 (10%)
Query: 45 IGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYR--CQATDAKGQ 101
I PE + WY EK+ + + + +G R L + N ++D G YR C A +
Sbjct: 8681 INYPEIKLSWYKGT-EKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIASAK 8739
Query: 102 TQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDN 161
V+E + ++V K+G+ + C+ S P W + N +
Sbjct: 8740 ----LTVIEPAWERHLQDVT----LKEGQTCTMTCQF-SVPNVKSEW-FRNGRILKPQGR 8789
Query: 162 RFAMLAN--NNLQILNINKSDEGIYRCEGR-VEARGEIDFRDIIVIVNVPPAISMPQKSF 218
+ + + L I ++ D+G Y C+ +E E+ + P I ++
Sbjct: 8790 HKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELR-------IEAEP-IQFTKRIQ 8841
Query: 219 NATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK--GSNTELTVRNIINSDG 276
N + TF C S + ++W++ + E++KY + G +T+ N+ D
Sbjct: 8842 NIVVSEHQSATFECEVS-FDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDE 8900
Query: 277 GPY-VCRATNKAGEDEKQAFLQVFVQPHIIQLK 308
G Y V GE A L + + ++LK
Sbjct: 8901 GVYSVIARLEPRGEARSTAELYLTTKEIKLELK 8933
Score = 43.9 bits (102), Expect = 6e-04
Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 16/151 (10%)
Query: 333 TWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQK- 391
TW + DG E K R G+ LHI DV+LSD+G Y C R+G +K
Sbjct: 11150 TWMK--DGSNIRESPKH---RFIADGK--DRKLHIIDVQLSDAGEYTC--VLRLGNKEKT 11200
Query: 392 -SMYLDIEYAP-KFISN-QTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTN 448
+ L +E P +F+ + +G P+ +SC++ N + WR+D ++ K
Sbjct: 11201 STAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL--NKERDVVWRKDGKIVVEK-PGR 11257
Query: 449 LKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
+ G L I D D G Y T N
Sbjct: 11258 IVPGVIGLMRALTINDADDTDAGTYTVTVEN 11288
Score = 43.5 bits (101), Expect = 8e-04
Identities = 30/105 (28%), Positives = 48/105 (45%), Gaps = 5/105 (4%)
Query: 202 IVIVNVPPAI--SMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIE--ENEKY 257
I+ NVPP I S+ KS T + G + G P P +SW ++G L++ E K
Sbjct: 19286 ILAENVPPRIDLSVAMKSL-LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKM 19344
Query: 258 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
++ + L + ++ D G Y A N +G L+V +P
Sbjct: 19345 AMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 43.1 bits (100), Expect = 0.001
Identities = 44/171 (25%), Positives = 67/171 (39%), Gaps = 9/171 (5%)
Query: 27 LSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIE 86
L V L G++ TC +W+ G + R + E +LTI + E
Sbjct: 8751 LQDVTLKEGQTCTMTCQFSVPNVKSEWFR-NGRILKPQGRHKTEVEHKVHKLTIADVRAE 8809
Query: 87 DAGIYRCQATDAKGQTQEATVVLEIY-QKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPA 145
D G Y C+ D E + L I + + F + + + + A C VS A
Sbjct: 8810 DQGQYTCKYEDL-----ETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSFDDA-I 8863
Query: 146 VSWLYHNEEVTTISDNRFAMLAN-NNLQILNINKSDEGIYRCEGRVEARGE 195
V+W E+T F + + I N+ DEG+Y R+E RGE
Sbjct: 8864 VTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGE 8914
Score = 43.1 bits (100), Expect = 0.001
Identities = 69/337 (20%), Positives = 117/337 (34%), Gaps = 47/337 (13%)
Query: 400 APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDK--------------------- 438
APK I ++ G+ I + + +P +I W +D+
Sbjct: 14680 APKVILRTSLEVK-RGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKG 14738
Query: 439 -------LVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILA 491
VLP ++ G L + + D G Y N G ++
Sbjct: 14739 EVQEEEPFVLPLTQRLSIDNSKKGESQ-LRVRDSLRPDHGLYMIKVENDHGIAKAPCTVS 14797
Query: 492 LADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVA--SEIWKIVRSHG 549
+ D P P ++ +T+ + P GG I +Y ++ K+ W +V S
Sbjct: 14798 VLDTPGPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTL 14857
Query: 550 VQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP-SPPSIHGQP----S 604
+ L Y RV A N G G + + L ++P PP +P
Sbjct: 14858 RHCKYSVTKLIEGKEYLFRVRAENRFGPGPPC---VSKPLVAKDPFGPPDAPDKPIVEDV 14914
Query: 605 SGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEV 664
+ S + + D G+PIL Y ++ R + K N ++ L + Y
Sbjct: 14915 TSNSMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVF 14974
Query: 665 QITAANRLG---YSEP----TVYEFSMPPKPNIIKDT 694
++ A N G +S P T ++ PP P I + T
Sbjct: 14975 RVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVT 15011
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/139 (23%), Positives = 57/139 (41%), Gaps = 16/139 (11%)
Query: 191 EARGEIDFRDIIVIVNVPPAISMPQKSFNAT--AERGEEMTFSCRASGSPEPAISWFRNG 248
E+ + +I VPP I + T + GE + +G P P I W +N
Sbjct: 15377 ESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNE 15436
Query: 249 KLIEE--------NEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV 300
+IE+ E+ + TEL++ + D G Y A+N+ G + ++V+
Sbjct: 15437 TVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYD 15496
Query: 301 QPH------IIQLKNETTY 313
+P + +K E+ Y
Sbjct: 15497 RPSPPRNLAVTDIKAESCY 15515
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/272 (20%), Positives = 108/272 (39%), Gaps = 28/272 (10%)
Query: 318 VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGR 377
+ L G P P++TW++ +G L + + L I + DSG+
Sbjct: 18624 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTM--------AFLVIPNSTRDDSGK 18675
Query: 378 YDCEAASRIGGHQKSMYLDIEY--APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWR 435
Y + G +K++++++ P +S+ + + SC V PP +
Sbjct: 18676 YSLTLVNPAG--EKAVFVNVRVLDTPGPVSDLKV-----SDVTKTSCHVSWAPPENDGGS 18728
Query: 436 RDKLVLPAKNTTNLKTYST----GRKMILEIAPTSDNDFGRYNCTATNHIG----TRFQE 487
+ + K + KT+ST +K + + + TA N G T +
Sbjct: 18729 QVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPK 18788
Query: 488 YILALADV--PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIV 545
+LA + P P +++ E+++ +A +++ P GG I Y +E +
Sbjct: 18789 PVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWT 18848
Query: 546 RSHGVQTM-VVLNNLEPNTTYEIRVAAVNGKG 576
V+ + +V+ L+ Y+ RVAA N G
Sbjct: 18849 EYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 18880
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 225 GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTE-LTVRNIINSDGGPYVCRA 283
GE F CR +G P+P ++W+ NG+LI +++++ ++ L + + + D G A
Sbjct: 1855 GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTA 1914
Query: 284 TNKAGEDEKQAFLQV 298
N G E + L++
Sbjct: 1915 ENPEGVIEHKVKLEI 1929
Score = 42.0 bits (97), Expect = 0.002
Identities = 49/273 (17%), Positives = 87/273 (31%), Gaps = 58/273 (21%)
Query: 128 QGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLAN-NNLQILNINKSDEGIYRC 186
+GE + C +S P+P V+W + ++ + D + + L I D G + C
Sbjct: 956 EGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTC 1015
Query: 187 EG--------------------------------RVEARGEIDFRDIIVI---------- 204
E + ++ RD+++
Sbjct: 1016 SAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAG 1075
Query: 205 VNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYIL----K 260
P A K G + F C+ G+P+P + W ++G + +Y + +
Sbjct: 1076 PGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQ 1135
Query: 261 GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTL 320
+L + D G Y NK GE A L ++ + QVT
Sbjct: 1136 TGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTA 1195
Query: 321 VCDAE--GEPIPEITWKRAVDGFTFTEGDKSLD 351
GE P GF ++E +K +
Sbjct: 1196 FVQEPKVGETAP---------GFVYSEYEKEYE 1219
Score = 42.0 bits (97), Expect = 0.002
Identities = 101/567 (17%), Positives = 202/567 (35%), Gaps = 89/567 (15%)
Query: 186 CEGR---VEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAI 242
C G+ +E + +DI+ + +++ + A+ GE++ G P P +
Sbjct: 27247 CAGQGEPIEMNEPVQAKDILEAPEIDLDVALRT---SVIAKAGEDVQVLIPFKGRPPPTV 27303
Query: 243 SWFRNGKLIEENEKYILKG--SNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF-LQVF 299
+W ++ K + + +Y ++ S++ LT+ + +D G Y+ N GE + ++V
Sbjct: 27304 TWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVL 27363
Query: 300 VQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQ 359
P Q G VTL+ D P I + + + D + R
Sbjct: 27364 DTPAACQKLQVKHVSRGTVTLLWDP-----PLIDGGSPIINYVIEKRDAT--KRTWSVVS 27416
Query: 360 HGSSSLHIKDVKLSDSGRY--------------DCEAASRIGGHQKSMYLDIEYAPKFIS 405
H SS K + LS+ + CE + + + + + K +
Sbjct: 27417 HKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIR-DLSMKDST 27475
Query: 406 NQTIYYSW-----EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMIL 460
++ SW +G + V+ W + T ++ + +L
Sbjct: 27476 KTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGI----SKTCEIEVSQLKEQSVL 27531
Query: 461 EIAPTSDNDFGRYNCTATNHIGTRFQEYILA----LADVPSSPYGVKI-----IEL---S 508
E + N+ G + I + E I+ L+D+P + V+I +EL
Sbjct: 27532 EFRVFAKNEKGLSDPVTIGPITVK--ELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKG 27589
Query: 509 QTTAKVSFNKPDSHGGVPIH-----HYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNT 563
+ +S+ K G+P+ + ++ I + HG + V+L+N
Sbjct: 27590 KPKPSISWLK----DGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRI 27645
Query: 564 TYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPI 623
I V + P +P P + + +D+GG I
Sbjct: 27646 AVPITVITLG----------------PPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEI 27689
Query: 624 LEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTV---- 679
Y ++ R + + W + + +L Y+ ++ A NR G S+P V
Sbjct: 27690 TCYSIEKR-ETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSII 27748
Query: 680 ---YEFSMPPKPN--IIKDTLFNGLGL 701
++F +P P +I + +G+ L
Sbjct: 27749 VAKHQFRIPGPPGKPVIYNVTSDGMSL 27775
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 206 NVPPAISMPQKSFNATA-ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG--S 262
NVPP + + F+ + GE + G P P ++WF++G IE+ +
Sbjct: 27953 NVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLG 28012
Query: 263 NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV 298
+T L VR+ G Y A N +G + + ++V
Sbjct: 28013 STSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKV 28048
Score = 41.2 bits (95), Expect = 0.004
Identities = 66/320 (20%), Positives = 123/320 (38%), Gaps = 47/320 (14%)
Query: 16 SGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVR 75
+G+ + + + V VG + F E + W++P+ + V++K
Sbjct: 16601 AGERKKTIIVDVLDVPGPVG-TPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESD 16659
Query: 76 SR--------LTIYNANIED-----AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVS 122
R +T NA ++ A +R A ++ G +E + L RE ++
Sbjct: 16660 RRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGP----FVETSEALVIREPIT 16715
Query: 123 PQEFKQGEDAEVVCRVSSSPAPAVSW-----------LYHNEEVTTISDNRFAMLANNNL 171
E + ED EV + + ++W + + E I +F + N+NL
Sbjct: 16716 VPE--RPEDLEV--KEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNL 16771
Query: 172 -----QILNINKSDEGIYRCEG-RVEARGEIDFRDIIVIVN---VPPAISMPQKSFNATA 222
+ + + D YR + +G+ F + PP + + + T
Sbjct: 16772 LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRD-KLTI 16830
Query: 223 ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNI--INSDGGPYV 280
GE + R SG P+P +SWF++ + E+++ +K + L + I SD G Y
Sbjct: 16831 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 16890
Query: 281 CRATNKAGEDEKQAFLQVFV 300
N G ++ F QV V
Sbjct: 16891 VVVENSTG--SRKGFCQVNV 16908
Score = 40.4 bits (93), Expect = 0.007
Identities = 30/131 (22%), Positives = 50/131 (38%), Gaps = 23/131 (17%)
Query: 163 FAMLANNNLQILNINKSDEGIYRCEGRVEA---RGEIDFRDIIVIVNVPPAISMPQKSFN 219
F ++A N ++ C VEA + ++ F+D +++
Sbjct: 21429 FRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVIL--------------- 21473
Query: 220 ATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK--GSNTELTVRNIINSDGG 277
+ GE SG P P + W ++GK +E K +K +T L ++ D G
Sbjct: 21474 ---KAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSG 21530
Query: 278 PYVCRATNKAG 288
Y ATN G
Sbjct: 21531 AYTLTATNPGG 21541
Score = 40.0 bits (92), Expect = 0.009
Identities = 17/70 (24%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 222 AERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK--YILKGSNTELTVRNIINSDGGPY 279
A+ G+ + G P+P ++W + +++++ ++ + ++T L + + SD GPY
Sbjct: 21077 AKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPY 21136
Query: 280 VCRATNKAGE 289
A N GE
Sbjct: 21137 PLTARNIVGE 21146
Score = 40.0 bits (92), Expect = 0.009
Identities = 23/90 (25%), Positives = 47/90 (52%), Gaps = 2/90 (2%)
Query: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKI-VRSHGV-QTM 553
P P K+I++++++ +S++KP GG I Y V+ +V+ W + G+ +T
Sbjct: 22838 PGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTN 22897
Query: 554 VVLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
+ + L Y R+ A+N G G+++ +
Sbjct: 22898 IEVEKLLEKHEYNFRICAINKAGVGEHADV 22927
Score = 40.0 bits (92), Expect = 0.009
Identities = 38/162 (23%), Positives = 60/162 (37%), Gaps = 15/162 (9%)
Query: 148 WLYHNEEVTTISDNRFAMLA---NNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVI 204
WL N T +SDN F + A + + + K+ G+ E+ G + RD
Sbjct: 28988 WLKCN--YTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS--ESTGPVTCRDEYA- 29042
Query: 205 VNVPPAISMPQKSFN--ATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK-- 260
PP + + T G ++ G PEP I W + K ++ EK L+
Sbjct: 29043 ---PPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYT 29099
Query: 261 GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
G ++ SD G Y N +G ++V P
Sbjct: 29100 GKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141
Score = 39.7 bits (91), Expect = 0.012
Identities = 133/674 (19%), Positives = 235/674 (34%), Gaps = 100/674 (14%)
Query: 29 KVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
+V + G+ + +C + + + W + R+V G+ LTI +A+ DA
Sbjct: 11221 EVTVVKGQPLYLSCE-LNKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDA 11279
Query: 89 GIYRCQATDAKG-QTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
G Y +A + V+E+ + + + Q K A C ++ P +
Sbjct: 11280 GTYTVTVENANNLECSSCVKVVEVIRDWLVKP-IRDQHVKPKGTAIFACDIAKD-TPNIK 11337
Query: 148 WLYHNEEVTTISDNRFAMLANNN---LQILNINKSDEGIYRCE---GRVEARGEIDFRDI 201
W +E+ +++ +L + N L+I N D Y E R A+ + R++
Sbjct: 11338 WFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREV 11397
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK- 260
++ + + T E +F S + P W G+L+ + +K
Sbjct: 11398 ELLKPIE----------DVTIYEKESASFDAEISEADIPG-QWKLKGELLRPSPTCEIKA 11446
Query: 261 -GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV--FVQPHIIQLKNETTYENGQ 317
G LT+ + G + +A N A L V + LK+ T E Q
Sbjct: 11447 EGGKRFLTLHKVKLDQAGEVLYQALNAI----TTAILTVKEIELDFAVPLKDVTVPERRQ 11502
Query: 318 VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGR 377
C E + W + D KS D + ++ L I D + D G
Sbjct: 11503 ARFECVLTRE--ANVIWSKGPDII------KSSD-KFDIIADGKKHILVINDSQFDDEGV 11553
Query: 378 YDCEAASRIGGHQKSMYLDIE-YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRR 436
Y E + G + S L + KF+S EG C++ S+ + W +
Sbjct: 11554 YTAE----VEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCEL-SHEKMHVVWFK 11608
Query: 437 DKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ L T + S G+ LE+ + +D + T + + A
Sbjct: 11609 NDAKLHTSRTVLIS--SEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFT 11666
Query: 497 SSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVL 556
+ +E + T K +K VP+ ++ D +E+ +++ G++ ++ +
Sbjct: 11667 VKLHDKTAVEKDEITLKCEVSK-----DVPVKWFK-DGEEIVPSPKYSIKADGLRRILKI 11720
Query: 557 -----------------NNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVR---EPSP 596
+ + N T E R+ V G +E+F E S
Sbjct: 11721 KKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYG----VEVFVGETAHFEIELSE 11776
Query: 597 PSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHL 656
P +HGQ + Q +P E I ED G K +IL +
Sbjct: 11777 PDVHGQ--------WKLKGQPLTASPDCEII--------ED--------GKKHILILHNC 11812
Query: 657 QWTMGYEVQITAAN 670
Q M EV AAN
Sbjct: 11813 QLGMTGEVSFQAAN 11826
Score = 38.9 bits (89), Expect = 0.020
Identities = 31/143 (21%), Positives = 65/143 (45%), Gaps = 22/143 (15%)
Query: 162 RFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNAT 221
+F + A N + + ++ + EG+Y EA+ ++ +PP I MP++ T
Sbjct: 18870 KFRVAARNAVGV-SLPREAEGVY------EAKEQL----------LPPKILMPEQ---IT 18909
Query: 222 AERGEEMTFSCRASGSPEPAISWFRN-GKLIEENEKYILKG-SNTELTVRNIINSDGGPY 279
+ G+++ G P P W + +++ + + K S++ L ++++ D G Y
Sbjct: 18910 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYY 18969
Query: 280 VCRATNKAGEDEKQAFLQVFVQP 302
A N +G D ++ + V P
Sbjct: 18970 SLTAENSSGTDTQKIKVVVMDAP 18992
Score = 38.5 bits (88), Expect = 0.026
Identities = 30/111 (27%), Positives = 49/111 (44%), Gaps = 2/111 (1%)
Query: 225 GEEMTFSCRASGSPEPAISWFRN-GKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRA 283
G+ + +G P P W + G+L ++ G+ +EL +++ + D G YV A
Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITA 15178
Query: 284 TNKAGEDEKQAFLQVFVQP-HIIQLKNETTYENGQVTLVCDAEGEPIPEIT 333
TN G A ++VF P ++ LK T + D E + EIT
Sbjct: 15179 TNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEIT 15229
Score = 37.7 bits (86), Expect = 0.045
Identities = 38/142 (26%), Positives = 64/142 (45%), Gaps = 27/142 (19%)
Query: 492 LADVPSSPYGVKI-IELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW-KIVRSHG 549
LA P P G + + +++ T + + KP+ GG I Y V+ +++ + W K S+
Sbjct: 21352 LALDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNI 21411
Query: 550 VQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSF 609
++ ++ L + YE RV A N G SPPS +PS
Sbjct: 21412 LENEFTVSGLTEDAAYEFRVIAKNAAG----------------AISPPS---EPSD---- 21448
Query: 610 KLSITKQDDGGAPILEYIVKYR 631
+IT +DD AP ++ VK++
Sbjct: 21449 --AITCRDDVEAPKIKVDVKFK 21468
Score = 37.4 bits (85), Expect = 0.058
Identities = 28/107 (26%), Positives = 52/107 (48%), Gaps = 8/107 (7%)
Query: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVK-EVA----SEIWKIVRSHG- 549
P P ++++ ++ + + + KP GG PI Y V+++ ++A E WK +
Sbjct: 18497 PGPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQ 18556
Query: 550 -VQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKI-EIFQTLPVREP 594
V+ + +L+ N YE RV A N G G +++ E + + EP
Sbjct: 18557 LVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEP 18603
Score = 36.2 bits (82), Expect = 0.13
Identities = 17/66 (25%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Query: 225 GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGS--NTELTVRNIINSDGGPYVCR 282
GE+++ P P +SW ++GK ++ +++ +K + L V + +D G Y
Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTIT 14460
Query: 283 ATNKAG 288
NK G
Sbjct: 14461 LENKLG 14466
Score = 35.8 bits (81), Expect = 0.17
Identities = 41/171 (23%), Positives = 68/171 (39%), Gaps = 15/171 (8%)
Query: 24 TISLSKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQR---VVVQKEGVRSRLT 79
T L V + G + F G P + W+ + ++IST V + R++LT
Sbjct: 9 TQPLQSVVVLEGSTATFEAHISGFPVPEVSWF--RDGQVISTSTLPGVQISFSDGRAKLT 66
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKL-----TFREVVSPQEFKQGEDAEV 134
I ++G Y +AT+ GQ AT E+ K F + + +QG +
Sbjct: 67 IPAVTKANSGRYSLKATNGSGQ---ATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 135 VCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLAN-NNLQILNINKSDEGIY 184
RV+ P P V + E+ + D + + + +L I D G Y
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTY 174
Score = 35.4 bits (80), Expect = 0.22
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Query: 30 VELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V + GE+ F C G P+ ++WY G+ I ++R V+ +G+ L I + D
Sbjct: 1850 VRVLEGETARFRCRVTGYPQPKVNWY-LNGQLIRKSKRFRVRYDGIH-YLDIVDCKSYDT 1907
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFREVV 121
G + A + +G E V LEI Q+ FR V+
Sbjct: 1908 GEVKVTAENPEG-VIEHKVKLEIQQREDFRSVL 1939
Score = 35.4 bits (80), Expect = 0.22
Identities = 26/106 (24%), Positives = 44/106 (41%), Gaps = 12/106 (11%)
Query: 206 NVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTE 265
++PP+I + K F E G + + G P P ++WF+ +N++ +L ++
Sbjct: 16115 DMPPSIDL--KEF-MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN 16171
Query: 266 ---------LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
L + SD G Y A N G K+ L V +P
Sbjct: 16172 KLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 16217
Score = 35.0 bits (79), Expect = 0.29
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 6/67 (8%)
Query: 236 GSPEPAISWFRN-GKLIEENEKYILKGSN-TELTVRNIINSDGGPYVCRATNKAGEDEKQ 293
G P P I+W R G+ ++ + I KG N T+L++ N +D G Y+ + N +G K
Sbjct: 24050 GRPTPEITWSREEGEFTDKVQ--IEKGVNYTQLSIDNCDRNDAGKYILKLENSSG--SKS 24105
Query: 294 AFLQVFV 300
AF+ V V
Sbjct: 24106 AFVTVKV 24112
Score = 35.0 bits (79), Expect = 0.29
Identities = 19/70 (27%), Positives = 31/70 (44%), Gaps = 2/70 (2%)
Query: 221 TAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGS--NTELTVRNIINSDGGP 278
T + G T SG P P ++W ++E ++ + + T LTV++ + D G
Sbjct: 28658 TCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGR 28717
Query: 279 YVCRATNKAG 288
Y N AG
Sbjct: 28718 YFLTLENTAG 28727
Score = 34.7 bits (78), Expect = 0.38
Identities = 34/172 (19%), Positives = 63/172 (36%), Gaps = 33/172 (19%)
Query: 324 AEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSS------------LHIKDVK 371
AE P+P+ + D + G +EVK + G S LH ++ K
Sbjct: 873 AEPTPLPQFPFADTPDTYKSEAG-------VEVKKEVGVSITGTTVREERFEVLHGREAK 925
Query: 372 LSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPAS 431
++++ R + P +S EG + + C + P +
Sbjct: 926 VTETARVPAPVEIPVT------------PPTLVSGLKNVTVIEGESVTLECHISGYPSPT 973
Query: 432 IHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
+ W R+ + + + T+ +G ++ I D GR+ C+A N GT
Sbjct: 974 VTWYREDYQIESSIDFQI-TFQSGIARLM-IREAFAEDSGRFTCSAVNEAGT 1023
Score = 34.3 bits (77), Expect = 0.49
Identities = 26/109 (23%), Positives = 43/109 (39%), Gaps = 15/109 (13%)
Query: 306 QLKNETTYENGQVTLVCDAEG-EPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSS 364
Q+ + E G V VC E + ++TW V +E + E+ + G +
Sbjct: 31573 QIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSE-------KYEITYEDGVAI 31625
Query: 365 LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSW 413
L++KD+ D G Y C+ + G D YA F+ Y +
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGE-------DSSYAELFVKGVREVYDY 31667
Score = 33.9 bits (76), Expect = 0.64
Identities = 19/65 (29%), Positives = 30/65 (46%), Gaps = 2/65 (3%)
Query: 236 GSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
G PEP + W + ++ + + + S T L + N+ D G Y N +G K AF
Sbjct: 25133 GRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSG--SKTAF 25190
Query: 296 LQVFV 300
+ V V
Sbjct: 25191 VNVRV 25195
Score = 33.5 bits (75), Expect = 0.84
Identities = 31/129 (24%), Positives = 55/129 (42%), Gaps = 7/129 (5%)
Query: 91 YRCQATDAKGQT--QEATVVLEIYQKLTFREVVSPQEF--KQGEDAEVVCRVSSSPAPAV 146
+R A +A G + +EA V E ++L +++ P++ K G+ + V P P
Sbjct: 18871 FRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTC 18930
Query: 147 SWLYHNEEVTTISDNRFAMLANNNLQIL-NINKSDEGIYRCEGRVEARGEIDFRDIIVIV 205
W +EV T S ++++ I+ ++ + D G Y E D + I V+V
Sbjct: 18931 KWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSL--TAENSSGTDTQKIKVVV 18988
Query: 206 NVPPAISMP 214
P P
Sbjct: 18989 MDAPGPPQP 18997
Score = 33.5 bits (75), Expect = 0.84
Identities = 32/139 (23%), Positives = 60/139 (43%), Gaps = 13/139 (9%)
Query: 22 QVTISLSKVELSVGESKFFTCTAIGEPES-IDWYNPQGEKII---STQRVVVQKEGVRSR 77
+ T+ L VGE+ F T PE + WY G+KI + ++ + + +
Sbjct: 31691 EFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYK-SGQKIKPGDNDKKYTFESDKGLYQ 31749
Query: 78 LTIYNANIEDAGIYRCQATDAKGQTQ-EATVVLEIYQKLT-------FREVVSPQEFKQG 129
LTI + +D Y A + G+ +A + + ++ T F+ +++ E ++G
Sbjct: 31750 LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEG 31809
Query: 130 EDAEVVCRVSSSPAPAVSW 148
+ RVS P P + W
Sbjct: 31810 QSVCFEIRVSGIPPPTLKW 31828
Score = 33.1 bits (74), Expect = 1.1
Identities = 63/263 (23%), Positives = 102/263 (38%), Gaps = 51/263 (19%)
Query: 50 SIDWYNPQ---GEKIISTQRVVVQKEGVRSRLTIYNANIEDAGI----------YRCQAT 96
S+ W P+ G +I+ V +Q +G T + +A I +R A
Sbjct: 22066 SLSWEKPEHDGGSRILG-YIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQ 22124
Query: 97 DAKGQTQEATVVLEIYQKLTFREVVSPQEFK---------QGEDAEVVCRVSSSPAPAVS 147
+ KG + + + + K ++V P FK GED +V P PAV+
Sbjct: 22125 NEKGISDPRQLSVPVIAK----DLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVT 22180
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNIN---KSDEGIYRCEGRVEARGEIDFRDIIVI 204
W H + V R + N +L I + D G Y + A I+ ++IV+
Sbjct: 22181 W--HKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVL 22238
Query: 205 VNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNT 264
+ P + P K TA + +T S G P+ + G I YI++ +T
Sbjct: 22239 -DKPGPPTGPVKMDEVTA---DSITLSW---GPPK-----YDGGSSI---NNYIVEKRDT 22283
Query: 265 ELTVRNIINSDGGPYVCRATNKA 287
T I+++ V R T KA
Sbjct: 22284 STTTWQIVSAT----VARTTIKA 22302
Score = 32.7 bits (73), Expect = 1.4
Identities = 24/104 (23%), Positives = 42/104 (40%), Gaps = 5/104 (4%)
Query: 127 KQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFA-MLANNNLQILNINKSDEGIYR 185
K GE + V P P V+W E+ + +L + +L + + + G+Y
Sbjct: 27971 KSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYT 28030
Query: 186 CEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMT 229
E + A G + + + P + P + N T GE+MT
Sbjct: 28031 VEAK-NASGSAKAEIKVKVQDTPGKVVGPIRFTNIT---GEKMT 28070
Score = 32.3 bits (72), Expect = 1.9
Identities = 32/116 (27%), Positives = 49/116 (42%), Gaps = 8/116 (6%)
Query: 27 LSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANI 85
L V + GES C G P ++ WY + S + + G+ +RL I A
Sbjct: 949 LKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGI-ARLMIREAFA 1007
Query: 86 EDAGIYRCQATDAKGQTQE----ATVVLEIYQKLT--FREVVSPQEFKQGEDAEVV 135
ED+G + C A + G A V E ++K T E + +E + E +VV
Sbjct: 1008 EDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVV 1063
Score = 32.3 bits (72), Expect = 1.9
Identities = 19/62 (30%), Positives = 28/62 (45%), Gaps = 1/62 (1%)
Query: 616 QDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYS 675
+D GG I YIV+ R W + I + HL M Y ++++ NR G S
Sbjct: 28766 KDGGGTEITNYIVEKRESGTT-AWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVS 28824
Query: 676 EP 677
+P
Sbjct: 28825 KP 28826
Score = 32.0 bits (71), Expect = 2.4
Identities = 44/218 (20%), Positives = 76/218 (34%), Gaps = 55/218 (25%)
Query: 40 FTC--TAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATD 97
F C T IG+P + + G+ + + R+ + E L A D+GI C+AT+
Sbjct: 1722 FECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATN 1781
Query: 98 AKGQTQEATVVLEIYQKLTFRE---------------------------VVSPQEFKQ-- 128
G + ++ +K E V + Q+ KQ
Sbjct: 1782 KYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKP 1841
Query: 129 -------------GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILN 175
GE A CRV+ P P V+W + + + R + L I++
Sbjct: 1842 DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVD 1901
Query: 176 INKSD-----------EGIYRCEGRVEARGEIDFRDII 202
D EG+ + ++E + DFR ++
Sbjct: 1902 CKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVL 1939
Score = 32.0 bits (71), Expect = 2.4
Identities = 22/71 (30%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 46 GEPE-SIDWYNPQGEKIISTQ-RVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQ 103
G+P S+ W +GE ++T RV V+ V + L +Y+ DAG Y + G T+
Sbjct: 20008 GKPAPSVSW--KKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAG-TK 20064
Query: 104 EATVVLEIYQK 114
E T+ +++ K
Sbjct: 20065 EGTISIKVVGK 20075
Score = 31.6 bits (70), Expect = 3.2
Identities = 19/97 (19%), Positives = 39/97 (40%), Gaps = 3/97 (3%)
Query: 209 PAISMPQKSFNATAER-GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSN--TE 265
P I +P + R G + SG P P I W+++ K ++ N ++ +
Sbjct: 26870 PVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLAS 26929
Query: 266 LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
+ +++ + G Y + N G +Q+ +P
Sbjct: 26930 ILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 26966
Score = 31.2 bits (69), Expect = 4.2
Identities = 23/84 (27%), Positives = 33/84 (39%), Gaps = 2/84 (2%)
Query: 400 APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLK-TYSTGRKM 458
AP F EG+ + P + W RD V+ ++ ++S GR
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 459 ILEIAPTSDNDFGRYNCTATNHIG 482
+ A T N GRY+ ATN G
Sbjct: 65 LTIPAVTKANS-GRYSLKATNGSG 87
Score = 31.2 bits (69), Expect = 4.2
Identities = 38/169 (22%), Positives = 67/169 (39%), Gaps = 16/169 (9%)
Query: 23 VTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQ--KEGVRSRLTI 80
+T+ SK G + I + E +W + + T VV K GV +
Sbjct: 27183 ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRV 27242
Query: 81 YNANIEDAG--IYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRV 138
N G I + AK + + L++ + + V++ K GED +V+
Sbjct: 27243 SAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTS---VIA----KAGEDVQVLIPF 27295
Query: 139 SSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNI---NKSDEGIY 184
P P V+W +E SD R+++ ++ +L I ++D G Y
Sbjct: 27296 KGRPPPTVTW--RKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKY 27342
Score = 30.4 bits (67), Expect = 7.1
Identities = 29/108 (26%), Positives = 47/108 (43%), Gaps = 7/108 (6%)
Query: 27 LSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRS-RLTIYNANI 85
L+ E G+S F G P + G+ + + + EG+ L I +
Sbjct: 31801 LANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLP 31860
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAE 133
ED G YR AT+ G T L++ ++L +++ QEFK E+ E
Sbjct: 31861 EDTGYYRVTATNTAGST-SCQAHLQV-ERLRYKK----QEFKSKEEHE 31902
Score = 30.0 bits (66), Expect = 9.3
Identities = 38/148 (25%), Positives = 59/148 (39%), Gaps = 22/148 (14%)
Query: 47 EPESIDWYNPQGEKIIS--TQRVVVQKEGVRSRLTIYNANIEDAGIYR--CQATDAKGQT 102
+P + W +++I RV EG R I ANI G R ++ AK
Sbjct: 17844 KPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDIL 17903
Query: 103 QEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSW------LYHNEEVT 156
V L++ T R+V++ + G+ ++ RV P P ++W L + V
Sbjct: 17904 HPPEVELDV----TCRDVIT---VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVD 17956
Query: 157 TISDNRFAMLANNNLQILNINKSDEGIY 184
I D L LQI ++D G Y
Sbjct: 17957 LIQD-----LPRVELQIKEAVRADHGKY 17979
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 162 bits (411), Expect = 9e-40
Identities = 144/515 (27%), Positives = 213/515 (41%), Gaps = 42/515 (8%)
Query: 29 KVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
+V + V +S C + G P + + G+ ++ G L I N I D
Sbjct: 2881 EVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNG--RILQILNTQITDI 2938
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFR---EVVSPQEFKQGEDAEVV--------CR 137
G Y C A + G ++ Y L V+ P+ E+ VV C
Sbjct: 2939 GRYVCVAENTAGSAKK-------YFNLNVHVPPSVIGPKS----ENLTVVVNNFISLTCE 2987
Query: 138 VSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEID 197
VS P P +SWL NE+ ++ N + LQI+ SD G Y C + GE
Sbjct: 2988 VSGFPPPDLSWL-KNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIA-INQAGESK 3045
Query: 198 FRDIIVIVNVPPAIS-MPQKSFNATAER-GEEMTFSCRASGSPEPAISWFRNGKLIEENE 255
+ + V VPP+I +S + R G ++ C ++ P P I+W++NG++I E+
Sbjct: 3046 -KKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITEST 3104
Query: 256 KYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYE- 314
+ L ++ SD G YVCRA N AG D+K L V+V P I + E E
Sbjct: 3105 HVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVET 3164
Query: 315 -NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS 373
+ VTL CDA G P P I W + E SL+ RI G S L I + S
Sbjct: 3165 ISNPVTLTCDATGIPPPTIAW---LKNHKRIENSDSLEVRI----LSGGSKLQIARSQHS 3217
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQ--TIYYSWEGNPINISCDVKSNPPAS 431
DSG Y C A++ G QK +L I+ P + + G + + C+ P
Sbjct: 3218 DSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL 3277
Query: 432 IHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILA 491
I W +D + + T ++ + G + + A TSD G+Y C ATN G + + L
Sbjct: 3278 IQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDT--GKYTCVATNPAGEEDRIFNLN 3335
Query: 492 LADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526
+ P+ E T S N G P
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTP 3370
Score = 153 bits (387), Expect = 6e-37
Identities = 130/508 (25%), Positives = 220/508 (43%), Gaps = 42/508 (8%)
Query: 13 LVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPES-IDWYNPQGEKIISTQRVVVQK 71
L +G+ L + + + V+L C A G P I WY ST + +
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLE--------CKAAGNPVPVITWYKDNRLLSGSTSMTFLNR 1972
Query: 72 EGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGED 131
+ + I +A I DAGIY+C A ++ G T E L+++ + +
Sbjct: 1973 GQI---IDIESAQISDAGIYKCVAINSAGAT-ELFYSLQVHVAPSISGSNNMVAVVVNNP 2028
Query: 132 AEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVE 191
+ C PAP+++WL V++ S+ + L + + SD G Y C V
Sbjct: 2029 VRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVA-VN 2087
Query: 192 ARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI 251
A GE RDI + V VPP I +++ + + E+ C++ P P ++W ++G +
Sbjct: 2088 AAGEKQ-RDIDLRVYVPPNIMGEEQNVSVLISQAVELL--CQSDAIPPPTLTWLKDGHPL 2144
Query: 252 EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI---IQLK 308
+ + + + L + + D G Y C ATN AG+ EK + ++V P+I +L
Sbjct: 2145 LKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT 2204
Query: 309 NETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSL-DGRIEVKGQHGSSSLHI 367
T E ++L+C++ G P P + WK+ +G L D V+ G L I
Sbjct: 2205 QLTVIEGNLISLLCESSGIPPPNLIWKK--------KGSPVLTDSMGRVRILSGGRQLQI 2256
Query: 368 KDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFI---SNQTIYYSWEGNPINISCDV 424
+ SD+ Y C A++ G +K L + P S+ T G I++ C+V
Sbjct: 2257 SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV 2316
Query: 425 KSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
+ PP ++ W +D P ++ G IL++ +D GRY C A N G
Sbjct: 2317 QGIPPPTVTWMKDG--HPLIKAKGVEILDEGH--ILQLKNIHVSDTGRYVCVAVNVAGMT 2372
Query: 485 FQEYILALADVPS------SPYGVKIIE 506
++Y L++ PS SP + ++E
Sbjct: 2373 DKKYDLSVHAPPSIIGNHRSPENISVVE 2400
Score = 153 bits (386), Expect = 7e-37
Identities = 135/520 (25%), Positives = 219/520 (42%), Gaps = 40/520 (7%)
Query: 7 FYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIIS--T 64
+Y L + V A ++ S V + +GE+ C A G P + + G+ I S T
Sbjct: 3236 YYFLSIQVPPSVAGAEIP---SDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET 3292
Query: 65 QRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQ 124
+R+ V G S L IY A D G Y C AT+ G+ ++ L +Y T R
Sbjct: 3293 ERIRVSANG--STLNIYGALTSDTGKYTCVATNPAGE-EDRIFNLNVYVTPTIRGNKDEA 3349
Query: 125 EFKQ---GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDE 181
E + CR + +P P ++WL + + S R + A ++I+ SD
Sbjct: 3350 EKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRL-LAAGQVIRIVRAQVSDV 3408
Query: 182 GIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPA 241
+Y C R +D + + V PP + + T +G + +C G+P P+
Sbjct: 3409 AVYTCV--ASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPS 3466
Query: 242 ISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ 301
++W R+G+ + + + L + D G Y C A+N+AGE K L+V
Sbjct: 3467 MAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEP 3526
Query: 302 PHI---IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKG 358
PHI + + + N + L C A G P P++TW + DG + D +V+
Sbjct: 3527 PHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMK--DGRPLPQTD-------QVQT 3577
Query: 359 QHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQ-----TIYYSW 413
G L I ++ D+GRY C A+S G K + + P T+
Sbjct: 3578 LGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVL--- 3634
Query: 414 EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
+ + C + PP I W R+ L A T ++ S GR L+I D Y
Sbjct: 3635 RNRQVTLECKSDAVPPPVITWLRNGERLQA--TPRVRILSGGR--YLQINNADLGDTANY 3690
Query: 474 NCTATNHIGTRFQEYILALADVPSSPYGVK--IIELSQTT 511
C A+N G +E+IL + P+ G + +I L+++T
Sbjct: 3691 TCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKST 3730
Score = 146 bits (368), Expect = 9e-35
Identities = 113/449 (25%), Positives = 182/449 (40%), Gaps = 19/449 (4%)
Query: 42 CTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQ 101
C G P + G+ I + G +L I A + + G+YRC A + G
Sbjct: 1756 CHVTGSPPPTIMWLKDGQLIDERDGFKILLNG--RKLVIAQAQVSNTGLYRCMAANTAGD 1813
Query: 102 TQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDN 161
++ V +S + + + + C + P P+++WL ++ V T N
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGN 1873
Query: 162 RFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNAT 221
+ LQI D G Y C A GE + I + V+ PP++ K N T
Sbjct: 1874 LKIQSSGRVLQIAKTLLEDAGRYTCVA-TNAAGETQ-QHIQLHVHEPPSLEDAGKMLNET 1931
Query: 222 AERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVC 281
+ C+A+G+P P I+W+++ +L+ + + + + SD G Y C
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKC 1991
Query: 282 RATNKAGEDEKQAFLQVFVQPHIIQLKN-ETTYENGQVTLVCDAEGEPIPEITW-KRAVD 339
A N AG E LQV V P I N N V L C+A G P P +TW K
Sbjct: 1992 VAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSP 2051
Query: 340 GFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEY 399
+F+ G + L G L + ++SD+GRY C A + G Q+ + L +
Sbjct: 2052 VSSFSNGLQVLS---------GGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV 2102
Query: 400 APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMI 459
P + + + + C + PP ++ W +D L K ++ + + +
Sbjct: 2103 PPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSI----SENRSV 2158
Query: 460 LEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
L+I D GRY C ATN G + Y
Sbjct: 2159 LKIEDAQVQDTGRYTCEATNVAGKTEKNY 2187
Score = 146 bits (368), Expect = 9e-35
Identities = 125/471 (26%), Positives = 195/471 (41%), Gaps = 22/471 (4%)
Query: 29 KVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
++ + V TC A G P + G + T +V Q G L I A +ED
Sbjct: 3537 EISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQV--QTLGGGEVLRISTAQVEDT 3594
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVV--CRVSSSPAPAV 146
G Y C A+ G + +V ++ P++ + +V C+ + P P +
Sbjct: 3595 GRYTCLASSPAGDDDKEYLV-RVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVI 3653
Query: 147 SWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN 206
+WL + E + R + LQI N + D Y C A R+ I+ VN
Sbjct: 3654 TWLRNGERLQATPRVRI-LSGGRYLQINNADLGDTANYTCVASNIAGKTT--REFILTVN 3710
Query: 207 VPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTEL 266
VPP I +S + + C A G P P I+W ++G ++ N N L
Sbjct: 3711 VPPNIKGGPQSLVILLNKSTVL--ECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFL 3768
Query: 267 TVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ-LKNETTYENGQVTLVCDAE 325
+++ +D G Y+C ATN AG D ++ LQV V P I N T N Q TL C+A
Sbjct: 3769 HIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEAT 3828
Query: 326 GEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASR 385
G P P I W++ +G R+ G SL I + D+ Y+C +
Sbjct: 3829 GIPKPSINWRK--NGHLLNVDQNQNSYRLLSSG-----SLVIISPSVDDTATYECTVTNG 3881
Query: 386 IGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN 445
G ++++ L ++ P T + + P I+C P SIHW ++ + L +
Sbjct: 3882 AGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRG 3941
Query: 446 TTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ S+G +EI T N GRY C A N G+ + L + + P
Sbjct: 3942 D-GYRILSSGA---IEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP 3988
Score = 145 bits (366), Expect = 2e-34
Identities = 127/517 (24%), Positives = 209/517 (40%), Gaps = 34/517 (6%)
Query: 78 LTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCR 137
+ I D+G+Y C AT+ G +A V L ++ + + + G+ ++ C
Sbjct: 1135 MKITETRTSDSGMYLCVATNIAGNVTQA-VKLNVHVPPKIQRGPKHLKVQVGQRVDIPCN 1193
Query: 138 VSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEID 197
+P P ++W + ++ + + L I SD GIY C A D
Sbjct: 1194 AQGTPLPVITWSKGGSTMLVDGEHHVSN-PDGTLSIDQATPSDAGIYTCVATNIAG--TD 1250
Query: 198 FRDIIVIVNVPPAISMPQKSFNATAER---GEEMTFSCRASGSPEPAISWFRNGKLIEEN 254
+I + V PP + + +N T + + + F C A G+P+P I W NG+ +
Sbjct: 1251 ETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGR 1310
Query: 255 EKYI-LKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII---QLKNE 310
E I + T L + ++ D G Y+C A N+AG E++ L+V V P I Q+ N
Sbjct: 1311 EPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNV 1370
Query: 311 TTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDV 370
+ N L C+ EG P P I W + D TE ++ + L +
Sbjct: 1371 SVLLNQLTNLFCEVEGTPSPIIMWYK--DNVQVTESST-------IQTVNNGKILKLFRA 1421
Query: 371 KLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFIS----NQTIYYSWEGNPINISCDVKS 426
D+GRY C+A + G QK +D+ P I N+ + + C VK
Sbjct: 1422 TPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVL--NRDVALECQVKG 1479
Query: 427 NPPASIHWRRD--KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
P IHW +D L L N L R +L + ND GRY CT +N G +
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-----RGQVLHLKNARRNDKGRYQCTVSNAAGKQ 1534
Query: 485 FQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHG-GVPIHHYQVDVKEVASEIWK 543
++ L + PS G ++S + + ++ G +P + D + + S
Sbjct: 1535 AKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQA 1594
Query: 544 IVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDY 580
+ G + + + TY VA V G + +
Sbjct: 1595 LYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Score = 144 bits (363), Expect = 3e-34
Identities = 123/466 (26%), Positives = 195/466 (41%), Gaps = 31/466 (6%)
Query: 30 VELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
+++ VG+ C A G P I W ++ + V +G L+I A DA
Sbjct: 1180 LKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT---LSIDQATPSDA 1236
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSP-----QEFKQGEDAEVVCRVSSSPA 143
GIY C AT+ G T E + L + + T ++ P QE + E C +P
Sbjct: 1237 GIYTCVATNIAG-TDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPK 1295
Query: 144 PAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIV 203
P + WL++ E+T + L I ++ D G Y C EA G + R +
Sbjct: 1296 PTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEA-GTTE-RKYNL 1353
Query: 204 IVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSN 263
V+VPP I ++ N + + C G+P P I W+++ + E+ +
Sbjct: 1354 KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNG 1413
Query: 264 TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII--QLKNETTYE-NGQVTL 320
L + D G Y C+A N AG +K + V V P II NE + N V L
Sbjct: 1414 KILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVAL 1473
Query: 321 VCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDC 380
C +G P P+I W + DG GD +++ + +GQ LH+K+ + +D GRY C
Sbjct: 1474 ECQVKGTPFPDIHWFK--DGKPLFLGDPNVE--LLDRGQ----VLHLKNARRNDKGRYQC 1525
Query: 381 EAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE---GNPINISCDVKSNPPASIHWRRD 437
++ G K + L I Y P I + + I + C+ + P +I W +D
Sbjct: 1526 TVSNAAGKQAKDIKLTI-YIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKD 1584
Query: 438 KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
P +++ G+ + + A SD+ Y C N GT
Sbjct: 1585 G--QPIMSSSQALYIDKGQYLHIPRAQVSDS--ATYTCHVANVAGT 1626
Score = 141 bits (355), Expect = 3e-33
Identities = 113/450 (25%), Positives = 196/450 (43%), Gaps = 27/450 (6%)
Query: 71 KEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGE 130
KE L I + D G Y C A + G T A ++ + +V + GE
Sbjct: 477 KESASVNLDIAKVTLSDEGFYECIAVSSAG-TGRAQTFFDVSEPPPVIQVPNNVTVTPGE 535
Query: 131 DAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRV 190
A + C + S+ ++W ++ +V R LAN +L++ ++ +D G Y C V
Sbjct: 536 RAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHC--MV 593
Query: 191 EARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKL 250
+ G + + V PP +++ K+ + T G E++ C A+G P+P I+W N
Sbjct: 594 SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG--GSEVSIMCSATGYPKPKIAWTVNDMF 651
Query: 251 IEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE 310
I + +Y + T L ++N D G Y C A+N AG D++ + L+ P ++ +++E
Sbjct: 652 IVGSHRYRMTSDGT-LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSE 710
Query: 311 TTYENGQVTLV-CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKD 369
G +T++ C G P P++ W + GD L + L I++
Sbjct: 711 LLVALGDITVMECKTSGIPPPQVKWFK---------GDLELRPSTFLIIDPLLGLLKIQE 761
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPP 429
+ D+G Y C A + G + LD+ P FI G+ + + C V+ P
Sbjct: 762 TQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPE 821
Query: 430 ASIHWRR-DKLVLPAK--NTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQ 486
+I WRR D + + ++ + +++ TG IL + +D G Y C A N G
Sbjct: 822 PTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWA---SDKGTYICEAENQFGKIQS 878
Query: 487 EYILALADVPS-----SPYGVKIIELSQTT 511
E + + + + SP +IE Q T
Sbjct: 879 ETTVTVTGLVAPLIGISPSVANVIEGQQLT 908
Score = 141 bits (355), Expect = 3e-33
Identities = 129/483 (26%), Positives = 204/483 (42%), Gaps = 36/483 (7%)
Query: 28 SKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIE 86
++V + + C G P I W+ + V + G L + NA
Sbjct: 1461 NEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRG--QVLHLKNARRN 1518
Query: 87 DAGIYRCQATDAKG-QTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPA 145
D G Y+C ++A G Q ++ + + I + V + ++ C P PA
Sbjct: 1519 DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPA 1578
Query: 146 VSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCE-GRVEARGEIDFRDIIVI 204
++W Y + + S + L I SD Y C V E F V
Sbjct: 1579 ITW-YKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFH---VD 1634
Query: 205 VNVPPAISMPQKS-FNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSN 263
V VPP I + N +T C+A+G+P P ++W ++G ++ N+ ++
Sbjct: 1635 VYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGG 1694
Query: 264 TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTY----ENGQVT 319
+L + + D G Y+C AT+ AGE E + + V V P I+ +ET+Y N +
Sbjct: 1695 KKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPP-AIEGGDETSYFIVMVNNLLE 1753
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYD 379
L C G P P I W + DG E D +I + G+ L I ++S++G Y
Sbjct: 1754 LDCHVTGSPPPTIMWLK--DGQLIDERD---GFKILLNGR----KLVIAQAQVSNTGLYR 1804
Query: 380 CEAASRIGGHQKSMYLDIEYAPKFIS---NQTIYYSWEGNPINISCDVKSNPPASIHWRR 436
C AA+ G H+K + + P S ++ + ++ P+ + C P SI W +
Sbjct: 1805 CMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK--PVALQCIANGIPNPSITWLK 1862
Query: 437 DKLVLPAKNTT--NLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALAD 494
D + NT NLK S+GR +L+IA T D GRY C ATN G Q L + +
Sbjct: 1863 DDQPV---NTAQGNLKIQSSGR--VLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHE 1917
Query: 495 VPS 497
PS
Sbjct: 1918 PPS 1920
Score = 141 bits (355), Expect = 3e-33
Identities = 124/485 (25%), Positives = 204/485 (42%), Gaps = 68/485 (14%)
Query: 26 SLSKVELSV--GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 82
S+ E++V G S C G P S+ W G+ + + V G+ L +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPSMAWLR-DGQPLGLDAHLTVSTHGMV--LQLLK 3495
Query: 83 ANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGED----------- 131
A ED+G Y C A++ G+ + ++ +V+ P E+
Sbjct: 3496 AETEDSGKYTCIASNEAGEVSKHFIL----------KVLEPPHINGSEEHEEISVIVNNP 3545
Query: 132 AEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVE 191
E+ C S PAP ++W+ + +D + L+I D G Y C
Sbjct: 3546 LELTCIASGIPAPKMTWMKDGRPLPQ-TDQVQTLGGGEVLRISTAQVEDTGRYTCLASSP 3604
Query: 192 ARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI 251
A D ++ +V V+VPP I+ + + T R ++T C++ P P I+W RNG+ +
Sbjct: 3605 AGD--DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERL 3662
Query: 252 EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI------- 304
+ + + L + N D Y C A+N AG+ ++ L V V P+I
Sbjct: 3663 QATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSL 3722
Query: 305 IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSS 364
+ L N++T L C AEG P P ITW++ DG + + G H S
Sbjct: 3723 VILLNKST------VLECIAEGVPTPRITWRK--------------DGAV-LAGNHARYS 3761
Query: 365 ------LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPI 418
LHI+ ++D+GRY C A + G ++ + L + P T
Sbjct: 3762 ILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQT 3821
Query: 419 NISCDVKSNPPASIHWRRDKLVLPA-KNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTA 477
++C+ P SI+WR++ +L +N + + S+G +I I+P+ D D Y CT
Sbjct: 3822 TLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVI--ISPSVD-DTATYECTV 3878
Query: 478 TNHIG 482
TN G
Sbjct: 3879 TNGAG 3883
Score = 137 bits (344), Expect = 5e-32
Identities = 125/478 (26%), Positives = 197/478 (41%), Gaps = 41/478 (8%)
Query: 28 SKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQR--VVVQKEGVRSRLTIYNANI 85
S++ + + C A G P + +G + ++ R V+ G L I A
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSP--QEFKQGEDAEVV--CRVSSS 141
EDAG Y C A + G T + +I + V+SP +E+ D + C
Sbjct: 4051 EDAGTYMCVAQNPAG-----TALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGL 4105
Query: 142 PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDI 201
P P ++W H + + R +L++ +LQI + D G Y C A +
Sbjct: 4106 PPPDITW--HKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKL 4163
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG 261
V +VPP I + + T + C A G P PAI+W ++ L+
Sbjct: 4164 TV--HVPPRIRSTEGHY--TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAE 4219
Query: 262 SNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENG-QVTL 320
EL + N++ D G Y C A N AGED L V V P +L + + G Q+ L
Sbjct: 4220 PYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRL 4279
Query: 321 VCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDC 380
C A G P+P++TW T + + + +G S L I+ V DSG Y C
Sbjct: 4280 SCKATGIPLPKLTW---------TFNNNIIPAHFD--SVNGHSELVIERVSKEDSGTYVC 4328
Query: 381 EAASRIGGHQKSMYLDIEYAPKFISNQTIYY--SWEGNPINISCDVKSNPPASIHWRRDK 438
A + +G + ++ ++ P F + + GN I ++C+VK +P +I W R
Sbjct: 4329 TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAI-LNCEVKGDPTPTIQWNRKG 4387
Query: 439 LVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ + + ++ G L I T + D G Y C ATN G + L L P
Sbjct: 4388 VDIEISH--RIRQLGNGS---LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP 4440
Score = 135 bits (339), Expect = 2e-31
Identities = 127/481 (26%), Positives = 207/481 (43%), Gaps = 58/481 (12%)
Query: 48 PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQT---QE 104
P +I W+ G + S + + + G L I NA ++AG Y C AT+ G+ E
Sbjct: 2604 PATITWFK-DGTPLESNRNIRILPGG--RTLQILNAQEDNAGRYSCVATNEAGEMIKHYE 2660
Query: 105 ATVVLE--IYQKLTFREVVSPQE--FKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISD 160
V + I + + +SP+E K + C + P+ ++SW + + SD
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLK--SD 2718
Query: 161 NRFAMLANNN-LQILNINKSDEGIYRC-EGRVEARGEIDFRDIIVIVNVPPAISMPQKSF 218
+ + AN + LQI SD G Y C + E+DF V + VPP+ +
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFD---VNIQVPPSFQKLWEIG 2775
Query: 219 NA--TAERGEE--------MTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTV 268
N T GE ++ C + +P P ++W+++G + ++K ++ L +
Sbjct: 2776 NMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQI 2835
Query: 269 RNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE-----TTYENGQVTLVCD 323
D G Y C A N+AGED Q ++V V P I ++ T N + C
Sbjct: 2836 PRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECL 2895
Query: 324 AEGEPIPEITWKRAVDGFTFTEGDKS---LDGRIEVKGQHGSSSLHIKDVKLSDSGRYDC 380
+ G P P +W++ DG E D +GRI L I + +++D GRY C
Sbjct: 2896 SSGSPAPRNSWQK--DGQPLLEDDHHKFLSNGRI----------LQILNTQITDIGRYVC 2943
Query: 381 EAASRIGGHQKSMYLDIEYAPKFI----SNQTIYYSWEGNPINISCDVKSNPPASIHWRR 436
A + G +K L++ P I N T+ + N I+++C+V PP + W +
Sbjct: 2944 VAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVN---NFISLTCEVSGFPPPDLSWLK 3000
Query: 437 DKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
++ P K TN GR L+I +D G Y C A N G +++ L + P
Sbjct: 3001 NE--QPIKLNTNTLIVPGGR--TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPP 3056
Query: 497 S 497
S
Sbjct: 3057 S 3057
Score = 133 bits (334), Expect = 8e-31
Identities = 117/495 (23%), Positives = 204/495 (41%), Gaps = 43/495 (8%)
Query: 5 LSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIIST 64
L Y+ + +SG ++ ++ G+S C G P + G +I
Sbjct: 2284 LQVYIRPTITNSGSHPTEIIVTR-------GKSISLECEVQGIPPPTVTWMKDGHPLIKA 2336
Query: 65 QRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQ 124
+ V + EG L + N ++ D G Y C A + G T + + SP+
Sbjct: 2337 KGVEILDEG--HILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPE 2394
Query: 125 EFKQGEDAEV--VCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEG 182
E V C S P P+++W V+ +S++ + L+++ D G
Sbjct: 2395 NISVVEKNSVSLTCEASGIPLPSITWFKDGWPVS-LSNSVRILSGGRMLRLMQTTMEDAG 2453
Query: 183 IYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAI 242
Y C R A E + V+V PP I + + + +T +C +G+P P I
Sbjct: 2454 QYTCVVRNAAGEERKIFGLSVLV--PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEI 2511
Query: 243 SWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
+W ++G+ ++E+E + + L + N+ G Y C A++ AG + L VFV P
Sbjct: 2512 TWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSP 2571
Query: 303 HIIQLKNE------TTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEV 356
I + ++ T N +LVC+A P ITW F +G L+ +
Sbjct: 2572 TIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW--------FKDG-TPLESNRNI 2622
Query: 357 KGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSW--- 413
+ G +L I + + ++GRY C A + G K + + Y P I+ ++
Sbjct: 2623 RILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKV-YIPPIINKGDLWGPGLSP 2681
Query: 414 ------EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSD 467
N + + C+ + P AS+ W +D P K+ ++ + G + ++ A SD
Sbjct: 2682 KEVKIKVNNTLTLECEAYAIPSASLSWYKDG--QPLKSDDHVNIAANGHTLQIKEAQISD 2739
Query: 468 NDFGRYNCTATNHIG 482
GRY C A+N G
Sbjct: 2740 T--GRYTCVASNIAG 2752
Score = 129 bits (324), Expect = 1e-29
Identities = 96/314 (30%), Positives = 141/314 (44%), Gaps = 25/314 (7%)
Query: 78 LTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCR 137
L + N +ED+G Y C A +A G+ TV L ++ TF E+ +GE + C+
Sbjct: 4224 LILENVVLEDSGFYTCVANNAAGEDTH-TVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK 4282
Query: 138 VSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEID 197
+ P P ++W ++N + D+ + ++ L I ++K D G Y C A +
Sbjct: 4283 ATGIPLPKLTWTFNNNIIPAHFDS---VNGHSELVIERVSKEDSGTYVCT----AENSVG 4335
Query: 198 FRDII--VIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE 255
F I V V PP S N G +C G P P I W R G IE +
Sbjct: 4336 FVKAIGFVYVKEPPVFKGDYPS-NWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISH 4394
Query: 256 KYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYEN 315
+ I + N L + +N D G Y C ATN+AG E+ L P II L+ T N
Sbjct: 4395 R-IRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSL-TLQSPPIITLEPVETVIN 4452
Query: 316 --GQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS 373
G++ L C A GEP P ITW R S D R+ V ++SL+I D +
Sbjct: 4453 AGGKIILNCQATGEPQPTITWSRQGHSI-------SWDDRVNVL---SNNSLYIADAQKE 4502
Query: 374 DSGRYDCEAASRIG 387
D+ ++C A + +G
Sbjct: 4503 DTSEFECVARNLMG 4516
Score = 127 bits (319), Expect = 4e-29
Identities = 117/443 (26%), Positives = 185/443 (41%), Gaps = 23/443 (5%)
Query: 42 CTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKG 100
C A G P+ SI+W G + Q + L I + +++D Y C T+ G
Sbjct: 3825 CEATGIPKPSINW-RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAG 3883
Query: 101 QTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISD 160
+ TV L + + + + + A + C S P P++ W + + D
Sbjct: 3884 DDKR-TVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGD 3942
Query: 161 NRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNA 220
+ +L++ ++IL + G Y C R A R + + V+ PP I PQ S
Sbjct: 3943 G-YRILSSGAIEILATQLNHAGRYTCVARNAAGSA--HRHVTLHVHEPPVIQ-PQPS-EL 3997
Query: 221 TAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYV 280
+ C A+G+P P I+W + G + + + + L + + D G Y+
Sbjct: 3998 HVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYM 4057
Query: 281 CRATNKAGEDEKQAFLQVFVQPHII-QLKNETTYENGQVTLVCDAEGEPIPEITWKRAVD 339
C A N AG + L V V P I LK + +TL C+A+G P P+ITW + D
Sbjct: 4058 CVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHK--D 4115
Query: 340 GFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEY 399
G E S+ R+ G SL I V+ D+G Y C AA+ G S L +
Sbjct: 4116 GRAIVE---SIRQRVLSSG-----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHV 4167
Query: 400 APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMI 459
P+ S + Y E + + C P +I+W++D ++L N T ++I
Sbjct: 4168 PPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLL--ANLLGKYTAEPYGELI 4225
Query: 460 LEIAPTSDNDFGRYNCTATNHIG 482
LE D+ F Y C A N G
Sbjct: 4226 LENVVLEDSGF--YTCVANNAAG 4246
Score = 126 bits (316), Expect = 1e-28
Identities = 120/489 (24%), Positives = 204/489 (41%), Gaps = 48/489 (9%)
Query: 30 VELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRS-RLTIYNANIED 87
V + +G + C G PE +I W I S V +R+ L I N D
Sbjct: 802 VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASD 861
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSP--------QEFKQGEDAEVVCRV- 138
G Y C+A + G+ Q T V T +V+P +G+ + C +
Sbjct: 862 KGTYICEAENQFGKIQSETTV-------TVTGLVAPLIGISPSVANVIEGQQLTLPCTLL 914
Query: 139 SSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDF 198
+ +P P W+ ++ + + + + ++ +L I + D G Y C A +
Sbjct: 915 AGNPIPERRWIKNSAML--LQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAG--TNN 970
Query: 199 RDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYI 258
+ V+V+V P I Q+ + G +T C+ASG+P+P++ W + G+LI +
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTI--EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKF 1028
Query: 259 LKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII----QLKNETTYE 314
G++ L V + + G YVC ATN AG +++ L V+V+P + L + E
Sbjct: 1029 SAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVE 1088
Query: 315 -----NGQVTLVCDAEGEPIPEITWKRAVDGFT-FTEGDKSLDGRIEVKGQHGSSSLHIK 368
+VTL C+ + P P ITW + + F+ L S S+ I
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLP----------SGSMKIT 1138
Query: 369 DVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNP 428
+ + SDSG Y C A + G +++ L++ PK G ++I C+ + P
Sbjct: 1139 ETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTP 1198
Query: 429 PASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
I W + + + + + + L I + +D G Y C ATN GT E
Sbjct: 1199 LPVITWSKGGSTM----LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEI 1254
Query: 489 ILALADVPS 497
L + + P+
Sbjct: 1255 TLHVQEPPT 1263
Score = 124 bits (311), Expect = 4e-28
Identities = 114/498 (22%), Positives = 208/498 (41%), Gaps = 29/498 (5%)
Query: 14 VSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPE-SIDWY-NPQGEKIISTQRVVVQK 71
VS ++QV + V ++ GE TC I + ++ W N + ++ R+ +
Sbjct: 516 VSEPPPVIQVP---NNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARI---R 569
Query: 72 EGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGED 131
L + + DAG Y C + ++G + A+V L + + + Q F G +
Sbjct: 570 TLANLSLELKSVKFNDAGEYHCMVS-SEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSE 628
Query: 132 AEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVE 191
++C + P P ++W + ++ + +R+ M ++ L I N D GIY C
Sbjct: 629 VSIMCSATGYPKPKIAWTVN--DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNS 686
Query: 192 ARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI 251
A G + + P + + + A G+ C+ SG P P + WF+ +
Sbjct: 687 A-GTDKQNSTLRYIEAPKLMVVQSELLVAL---GDITVMECKTSGIPPPQVKWFKGDLEL 742
Query: 252 EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNET 311
+ I+ L ++ + D G Y C A N+AG + L V P IQ +
Sbjct: 743 RPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADV 802
Query: 312 TYENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDV 370
+ E G VTL C +G P P I W+R +D S+ +++ + +L I ++
Sbjct: 803 SMEIGSNVTLPCYVQGYPEPTIKWRR-LDNMPIFSRPFSVSSISQLR----TGALFILNL 857
Query: 371 KLSDSGRYDCEAASRIGGHQKSMYLDIE--YAPKFISNQTIYYSWEGNPINISCDVKS-N 427
SD G Y CEA ++ G Q + + AP + ++ EG + + C + + N
Sbjct: 858 WASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGN 917
Query: 428 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
P W ++ +L +++ + L I D G Y C A+N GT +
Sbjct: 918 PIPERRWIKNSAMLLQNPYITVRSDGS-----LHIERVQLQDGGEYTCVASNVAGTNNKT 972
Query: 488 YILALADVPSSPYGVKII 505
+ + +P+ +G +I+
Sbjct: 973 TSVVVHVLPTIQHGQQIL 990
Score = 103 bits (258), Expect = 5e-22
Identities = 90/369 (24%), Positives = 151/369 (40%), Gaps = 22/369 (5%)
Query: 130 EDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGR 189
+ ++ C V S +S++ + VT D A+ NL I + SDEG Y C
Sbjct: 445 QPGQIPCSVDSLLPFTLSFVRNG--VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIA- 501
Query: 190 VEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGK 249
V + G + + PP I +P N T GE +C + + ++W RN +
Sbjct: 502 VSSAGTGRAQTFFDVSEPPPVIQVPN---NVTVTPGERAVLTCLIISAVDYNLTWQRNDR 558
Query: 250 LIEENEKYILKG-SNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI-IQL 307
+ E ++ +N L ++++ +D G Y C +++ G FL V P + +
Sbjct: 559 DVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP 618
Query: 308 KNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHI 367
KN++ +V+++C A G P P+I W T D + G + +L I
Sbjct: 619 KNQSFTGGSEVSIMCSATGYPKPKIAW---------TVNDMFIVGSHRYR-MTSDGTLFI 668
Query: 368 KDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSN 427
K+ D+G Y C A++ G +++ L APK + Q+ G+ + C
Sbjct: 669 KNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGI 728
Query: 428 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
PP + W + L L + +L+I T D D G Y C A N G +
Sbjct: 729 PPPQVKWFKGDLELRPSTFLIIDPLLG----LLKIQETQDLDAGDYTCVAINEAGRATGK 784
Query: 488 YILALADVP 496
L + P
Sbjct: 785 ITLDVGSPP 793
Score = 90.5 bits (223), Expect = 6e-18
Identities = 75/294 (25%), Positives = 120/294 (40%), Gaps = 18/294 (6%)
Query: 204 IVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSN 263
IV P ++MP+K+ + G+ C +S+ RNG + ++ Y+ + ++
Sbjct: 426 IVPDAPKVTMPEKTPGYYLQPGQ---IPCSVDSLLPFTLSFVRNGVTLGVDQ-YLKESAS 481
Query: 264 TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVC 322
L + + SD G Y C A + AG Q F V P +IQ+ N T G+ L C
Sbjct: 482 VNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTC 541
Query: 323 DAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEA 382
+TW+R + D L ++ + SL +K VK +D+G Y C
Sbjct: 542 LIISAVDYNLTWQR-------NDRDVRLAEPARIR-TLANLSLELKSVKFNDAGEYHCMV 593
Query: 383 ASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLP 442
+S G S++L ++ PK G+ ++I C P I W + + +
Sbjct: 594 SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIV 653
Query: 443 AKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ + S G I AP D G Y C A+N GT Q L + P
Sbjct: 654 GSH--RYRMTSDGTLFIKNAAP---KDAGIYGCLASNSAGTDKQNSTLRYIEAP 702
Score = 31.6 bits (70), Expect = 3.2
Identities = 30/124 (24%), Positives = 50/124 (40%), Gaps = 6/124 (4%)
Query: 25 ISLSKVE--LSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 82
I+L VE ++ G C A GEP+ ++ QG I RV V + L I +
Sbjct: 4442 ITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLS---NNSLYIAD 4498
Query: 83 ANIEDAGIYRCQATDAKGQT-QEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSS 141
A ED + C A + G V+++++ + G+ + R+ +
Sbjct: 4499 AQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQ 4558
Query: 142 PAPA 145
P PA
Sbjct: 4559 PLPA 4562
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 162 bits (410), Expect = 1e-39
Identities = 161/669 (24%), Positives = 280/669 (41%), Gaps = 53/669 (7%)
Query: 51 IDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEAT--VV 108
+ W+ +G KII + R+ + E ++L I DAG Y QA + K + + +
Sbjct: 223 VTWFR-EGHKIIPSNRIAITLE---NQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIH 278
Query: 109 LEIYQKLTFREVVSPQEFKQGEDAEVV---------CRVSSSPAP--AVSWLYHNEEVTT 157
L I + + E ++P + VV C S+ P +V+W + +T+
Sbjct: 279 LSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITS 338
Query: 158 ISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKS 217
+ L I N +D G Y CE + R + + P +
Sbjct: 339 GLHS-----FGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPE 393
Query: 218 FNATAERGEEMTFSCRASGSPEPAISWFRNGKLIE--ENEKYILKGSNTELTVRNIINSD 275
+AE E + C+A G P P + W+++ I +N +Y + S L ++ + D
Sbjct: 394 SRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG-LRIQKLRPED 452
Query: 276 GGPYVCRATNKAGEDEKQAFLQVF-VQPHIIQLKNETTYENGQVTLV-CDAEGEPIPEIT 333
G + C A+N+ GE + +L V + P Q +TT +G ++ C+ G P P IT
Sbjct: 453 SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAIT 512
Query: 334 WKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSM 393
WKR + G + + ++ S L I V + D+G Y C AA+ G S
Sbjct: 513 WKR--ENHILASGSVRIPRFMLLE----SGGLQIAPVFIQDAGNYTCYAANTEGSLNASA 566
Query: 394 YLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIH--WRRDKLVLPAKNTTNLKT 451
L + + + +G + C +P S+ W++D + L +T+ +
Sbjct: 567 TLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVV 626
Query: 452 YSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTT 511
G L I+ T D G Y+C + G + L + ++P SP + + S +
Sbjct: 627 EKDGS---LLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHS 683
Query: 512 AKV--SFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSH--GVQTMVVLNNLEPNTTYEI 567
V S+ +P G PI +Y V++ E S WK+ S+ T V ++ L P TY+
Sbjct: 684 HAVVLSWVRPFD-GNSPILYYIVELSENNSP-WKVHLSNVGPEMTGVTVSGLTPARTYQF 741
Query: 568 RVAAVNGKGQGDYSKIEIFQTLPVREPSPPS----IHGQPSSGKSFKLSITKQDDGGAPI 623
RV AVN G+G YS LP PS P G+ + + + + +
Sbjct: 742 RVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVL 801
Query: 624 LEYIVKYRSKDKEDQWLEKKVQGNKDH--IILEHLQWTMGYEVQITAAN--RLGYSEPTV 679
YI++YR ++ ++ + + + ++ + + WT YE+Q+ A N LG V
Sbjct: 802 RGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQ-YEIQVAAYNGAGLGVFSRAV 860
Query: 680 YEFSMPPKP 688
E+++ P
Sbjct: 861 TEYTLQGVP 869
Score = 124 bits (312), Expect = 3e-28
Identities = 157/659 (23%), Positives = 257/659 (38%), Gaps = 80/659 (12%)
Query: 76 SRLTIYNANIE---------DAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEF 126
S LT Y++ + DAG YRC + G + +++ +F + +
Sbjct: 143 SELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTV 202
Query: 127 KQGEDAEV-VCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYR 185
QG A + + ++S P P V+W ++ I NR A+ N L IL SD G Y
Sbjct: 203 SQGRAAILNLLPITSYPRPQVTWFREGHKI--IPSNRIAITLENQLVILATTTSDAGAYY 260
Query: 186 CEGRVEARGEID---------FRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASG 236
+ E GE RD+ + P I +P + + A E T C AS
Sbjct: 261 VQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVA-GSSETTLECIASA 319
Query: 237 SP--EPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRAT--NKAGEDEK 292
P + +++W RNG I L LT+ N ++D GPYVC A A E +
Sbjct: 320 RPVEDLSVTWKRNGVRITSG----LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPAR 375
Query: 293 QAFLQVFVQPHIIQLKNETTYE---NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKS 349
++P + E+ V + C A G P+P + W + D + + +
Sbjct: 376 ATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYK--DAISIS---RL 430
Query: 350 LDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI-EYAPKFISNQT 408
+ R +V S L I+ ++ DSG + C A++ G Q YLD+ AP F
Sbjct: 431 QNPRYKVL---ASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPV 487
Query: 409 IYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDN 468
+G + C+V P +I W+R+ +L A + + + L+IAP
Sbjct: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHIL-ASGSVRIPRFMLLESGGLQIAPVFIQ 546
Query: 469 DFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIH 528
D G Y C A N G+ L + + S I+ + + H G H
Sbjct: 547 DAGNYTCYAANTEGSLNASATLTVWNRTS------IVHPPEDHVVIKGTTATLHCGA-TH 599
Query: 529 HYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYS------- 581
+V ++ V WK + + T + + + ++ GDYS
Sbjct: 600 DPRVSLRYV----WK--KDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEG 653
Query: 582 -------KIEIFQTLPVREPSPPSIHGQPSSGKSFK--LSITKQDDGGAPILEYIVKYRS 632
++E+ + LP SP ++ P+S S LS + DG +PIL YIV+
Sbjct: 654 GNDSRMARLEVIE-LP---HSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSE 709
Query: 633 KDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLG---YSEPTVYEFSMPPKP 688
+ + V + + L Y+ ++ A N +G YS T +P +P
Sbjct: 710 NNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAET-SRLMLPEEP 767
Score = 107 bits (266), Expect = 6e-23
Identities = 130/551 (23%), Positives = 208/551 (37%), Gaps = 53/551 (9%)
Query: 77 RLTIYNANIEDAGIYRCQAT--DAKGQTQEATVVLEIYQKLTFR-EVVSPQEFKQGEDAE 133
RLTI N D G Y C+A + + AT L I + F E S + E +
Sbjct: 346 RLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVD 405
Query: 134 VVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEAR 193
+ C+ P P + W ++ + + R+ +LA+ L+I + D GI++C E
Sbjct: 406 IGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEG- 464
Query: 194 GEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEE 253
GEI + + N+ P + Q+ + T G C SG+P+PAI+W R ++
Sbjct: 465 GEIQTHTYLDVTNIAPVFT--QRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILAS 522
Query: 254 NEKYILKGSNTE---LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE 310
I + E L + + D G Y C A N G A L V+ + I+ +
Sbjct: 523 GSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPED 582
Query: 311 TTYENGQV-TLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKD 369
G TL C A +P + + D T S RI V+ SL I
Sbjct: 583 HVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTS---RIVVEKD---GSLLISQ 636
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISN----------QTIYYSW----EG 415
D G Y CE S G + L++ P N + SW +G
Sbjct: 637 TWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDG 696
Query: 416 NPINISCDVK---SNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGR 472
N + V+ +N P +H V P + + R + ++ G+
Sbjct: 697 NSPILYYIVELSENNSPWKVHLSN---VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQ 753
Query: 473 YNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFN---KPDS-HGGVPIH 528
Y+ + L L + P S I+ +T + P++ H GV +
Sbjct: 754 YSAETSR----------LMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGV-LR 802
Query: 529 HY--QVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIF 586
Y + + + E + + ++ +L T YEI+VAA NG G G +S+
Sbjct: 803 GYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTE 862
Query: 587 QTLPVREPSPP 597
TL +PP
Sbjct: 863 YTLQGVPTAPP 873
Score = 79.7 bits (195), Expect = 1e-14
Identities = 89/380 (23%), Positives = 146/380 (38%), Gaps = 47/380 (12%)
Query: 123 PQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEG 182
PQ +G + C S W+ + E+TT S + I ++ K D G
Sbjct: 113 PQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYS-------SEYKYIIPSLQKLDAG 165
Query: 183 IYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGS-PEPA 241
YRC R + + + + + + Q+ T +G + S P P
Sbjct: 166 FYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRK---TVSQGRAAILNLLPITSYPRPQ 222
Query: 242 ISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATN-KAGEDEKQAFLQVFV 300
++WFR G I + + + N +L + SD G Y +A N K GE++ F+ + +
Sbjct: 223 VTWFREGHKIIPSNRIAITLEN-QLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSI 281
Query: 301 ----------QPHIIQLKNETTYENG--QVTLVCDAEGEPIPE--ITWKRAVDGFTFTEG 346
P I+ + G + TL C A P+ + +TWKR +G T G
Sbjct: 282 ARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR--NGVRITSG 339
Query: 347 DKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAA---SRIGGHQKSMYLDIEYAPKF 403
S R L I + +D+G Y CEAA S + + +L I P F
Sbjct: 340 LHSFGRR-----------LTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYF 388
Query: 404 ISNQTIYYSWE-GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEI 462
+ S E ++I C P ++ W +D + + K ++G I ++
Sbjct: 389 TAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKL 448
Query: 463 APTSDNDFGRYNCTATNHIG 482
P D G + C A+N G
Sbjct: 449 RP---EDSGIFQCFASNEGG 465
Score = 47.4 bits (111), Expect = 6e-05
Identities = 60/240 (25%), Positives = 113/240 (47%), Gaps = 26/240 (10%)
Query: 459 ILEIAPTSDNDFGRYNCTATNHIG-------TRFQEYILALADVPSSPYGVKIIELSQTT 511
+LEI + R+ N +G +R + + A DV +P V + S+T+
Sbjct: 1132 MLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDV--APTSVTVRTASETS 1189
Query: 512 AKVSFNK-PDS-HGGVP------IHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNT 563
++ + PDS + G P I +++ D++ +S + ++V S ++ + LE
Sbjct: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQ--SSAVAQVV-SDRLEREFTIEELEEWM 1246
Query: 564 TYEIRVAAVNGKGQGDYSKIEIFQTL-PVREPSPPSIHGQPSSGKSFKL---SITKQDDG 619
YE+++ A N G G +S++ +T V +P ++ + S L S+ +QD
Sbjct: 1247 EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQN 1306
Query: 620 GAPILEYIVKYRSKDKEDQWLEKKVQGN-KDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
G IL Y + +R+KD + + V+GN +L L+ + YE+Q+ A R+G P+
Sbjct: 1307 GL-ILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPS 1365
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/124 (24%), Positives = 52/124 (41%), Gaps = 6/124 (4%)
Query: 519 PDSHGGVPIHHYQVDVKEVASEIWKIVRSH--GVQTMVVLNNLEPNTTYEIRVAAVNGKG 576
P S G PI ++ + V+E+ W+ S T V++ L P T+Y++R+ A N G
Sbjct: 1501 PGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIG 1560
Query: 577 QGDYSK----IEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRS 632
D+S + Q +P P S +S + + + + Y + YR
Sbjct: 1561 DSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRE 1620
Query: 633 KDKE 636
+ E
Sbjct: 1621 LEYE 1624
Score = 42.0 bits (97), Expect = 0.002
Identities = 43/191 (22%), Positives = 79/191 (41%), Gaps = 10/191 (5%)
Query: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVA-----SEIWKIVRSHGV 550
P +P + E++ TT VS+ +P + G+ + Y+V + +A S++ +
Sbjct: 1802 PGAPSFLAFSEITSTTLNVSWGEPAAANGI-LQGYRVVYEPLAPVQGVSKVVTVEVRGNW 1860
Query: 551 QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFK 610
Q + + +L TY RV A G + I P P S
Sbjct: 1861 QRWLKVRDLTKGVTYFFRVQA-RTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELT 1919
Query: 611 LSITKQDDGGAPILEYIVKYRSKDKE--DQWLEKKVQGNKDHII-LEHLQWTMGYEVQIT 667
L T+ G P Y+++ R D+ D +++ + + + L+ L+ + YE ++
Sbjct: 1920 LQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVV 1979
Query: 668 AANRLGYSEPT 678
A N GY EP+
Sbjct: 1980 AVNEAGYGEPS 1990
Score = 35.8 bits (81), Expect = 0.17
Identities = 39/157 (24%), Positives = 64/157 (40%), Gaps = 17/157 (10%)
Query: 494 DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
D P + + E+ T+ KVS+ +P G+ I YQ+ + ++ + T
Sbjct: 970 DKPGAVGHLSFTEILDTSLKVSWQEPLEKNGI-ITGYQISWEVYGRNDSRLTHTLNSTTH 1028
Query: 554 VV-LNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPS-------S 605
+ L TTY I VAAV G G + + + PP + G PS S
Sbjct: 1029 EYKIQGLSSLTTYTIDVAAVTAVGTG------LVTSSTISSGVPPDLPGAPSNLVISNIS 1082
Query: 606 GKSFKLSITKQDDGGAPILEYIVKYR--SKDKEDQWL 640
+S L DG I +IV+ + + E++W+
Sbjct: 1083 PRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWV 1119
Score = 33.5 bits (75), Expect = 0.84
Identities = 23/102 (22%), Positives = 43/102 (42%), Gaps = 5/102 (4%)
Query: 498 SPYGVKIIELSQTTAKVSFNKPDSHGG-VPIHHYQVDVKEVASEIW----KIVRSHGVQT 552
SP + + ++++ ++++ + H G P Y ++ + +W K +
Sbjct: 1902 SPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSY 1961
Query: 553 MVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP 594
+ L+ L TYE RV AVN G G+ S + V P
Sbjct: 1962 TLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 161 bits (408), Expect = 2e-39
Identities = 146/574 (25%), Positives = 248/574 (43%), Gaps = 42/574 (7%)
Query: 122 SPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLA-NNNLQILNINKSD 180
S +E +G + C P P + W +E + NR LQI++++++D
Sbjct: 272 SNKEELRGNVLSLECIAEGLPTPIIYWA---KEDGMLPKNRTVYKNFEKTLQIIHVSEAD 328
Query: 181 EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP 240
G Y+C + A G I + + P I+ PQ N GE+ T CRA+G+P+P
Sbjct: 329 SGNYQCIAK-NALGAIHHTISVRVKAAPYWITAPQ---NLVLSPGEDGTLICRANGNPKP 384
Query: 241 AISWFRNGKLIE-ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVF 299
ISW NG IE + K + N+ Y C A+N+ G AF+ V
Sbjct: 385 RISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL 444
Query: 300 VQPHIIQLKNETTYE---NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEV 356
+P I T Y+ N L C G P+P I W + G E ++
Sbjct: 445 AEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHE---------DI 495
Query: 357 KGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE-G 415
H + +L I + +G Y C A +++G + ++L+I+ P +I Q Y + G
Sbjct: 496 YVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK-DPTWIVKQPEYAVVQRG 554
Query: 416 NPINISCDVKSNPPASIH--WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
+ ++ C VK + S+ W +D LP+ + K L +A SD+D G Y
Sbjct: 555 SMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVD------KDHLVVADVSDDDSGTY 608
Query: 474 NCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 533
C A + + +L++ DVP+ P+ +++ + + ++S+ D + PI + ++
Sbjct: 609 TCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDNNS-PITKFIIE 667
Query: 534 VKEVASE--IW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLP 590
++ + +W G QT L L P Y RV AVN G+ S+
Sbjct: 668 YEDAMHKPGLWHHQTEVSGTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTK 726
Query: 591 VREP--SPPSIHGQPSSGKSFKLSITKQD--DGGAPILEYIVKYRSKDKEDQWLEKKVQG 646
EP +P ++ G S + ++ + + P L+Y V +R KD +D+W V
Sbjct: 727 ASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEW-TSVVVA 785
Query: 647 NKDHIILEHLQWTMGYEVQITAANRLGYS-EPTV 679
N I+ + Y +++ A N +G++ EP V
Sbjct: 786 NVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAV 819
Score = 97.8 bits (242), Expect = 4e-20
Identities = 154/696 (22%), Positives = 258/696 (37%), Gaps = 87/696 (12%)
Query: 36 ESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA-----G 89
E+ C A G+P S W I +V K G + I N E G
Sbjct: 56 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGT--LIINIMSEGKAETYEG 113
Query: 90 IYRCQATDAKGQTQEATVVLEIYQK-LTFREVVSPQEFKQGEDAEVVCRVSSS-PAPAVS 147
+Y+C A + +G +V+ + L +E + P + G+ + CR P P +
Sbjct: 114 VYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIF 173
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSD-EGIYRCEGRVEARGEIDFRDIIVIVN 206
W+ ++ + S+ R + N +L N+ D Y C R I + I +
Sbjct: 174 WMDNSFQRLPQSE-RVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKV 232
Query: 207 V---------------------------PPAISMPQKSFNATAE-RGEEMTFSCRASGSP 238
+ PP P+ + + E RG ++ C A G P
Sbjct: 233 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 292
Query: 239 EPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV 298
P I W + ++ +N + + K L + ++ +D G Y C A N G ++V
Sbjct: 293 TPIIYWAKEDGMLPKN-RTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRV 351
Query: 299 FVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKS--LDGRIE 355
P+ I G+ TL+C A G P P I+W D S +DG
Sbjct: 352 KAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDG--- 408
Query: 356 VKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISN--QTIYYSW 413
++ +V+ S Y C A++ G + ++++ P I T+Y
Sbjct: 409 -------DTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVI 461
Query: 414 EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTT-NLKTYSTGRKMILEIAPTSDNDFGR 472
P + C +P +I W + AK + + Y LEI + G
Sbjct: 462 ANRPALLDCAFFGSPLPTIEWFKG-----AKGSALHEDIYVLHENGTLEIPVAQKDSTGT 516
Query: 473 YNCTATNHIGTRFQEYILALAD----VPSSPYGVKIIELSQTTAKVSFN---KPDSHGGV 525
Y C A N +G E L + D V Y V Q + VSF K D +
Sbjct: 517 YTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAV-----VQRGSMVSFECKVKHDHTLSL 571
Query: 526 PIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI 585
+ + + + + E + + + H V V + + + TY V S +
Sbjct: 572 TVLWLKDNRELPSDERFTVDKDHLVVADV---SDDDSGTY----TCVANTTLDSVSASAV 624
Query: 586 FQTLPVREPSPP-SIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYR-SKDKEDQW-LEK 642
+ V P+PP + KS +LS T DD +PI ++I++Y + K W +
Sbjct: 625 LSVVDV--PNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQT 682
Query: 643 KVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
+V G + L+ L + Y ++ A N +G S P+
Sbjct: 683 EVSGTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPS 717
Score = 71.2 bits (173), Expect = 4e-12
Identities = 97/459 (21%), Positives = 165/459 (35%), Gaps = 71/459 (15%)
Query: 107 VVLEIYQKLTFREVVSPQEF--KQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFA 164
V L++ Q T + SP+++ E+ + C P P+ SW + D
Sbjct: 32 VPLDLVQPPTITQQ-SPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVT 90
Query: 165 MLANNNLQILNI-----NKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFN 219
M I+NI ++ EG+Y+C R E RG +I+V + P + +K
Sbjct: 91 MKPGTGTLIINIMSEGKAETYEGVYQCTARNE-RGAAVSNNIVVRPSRSP-LWTKEKLEP 148
Query: 220 ATAERGEEMTFSCRAS-GSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSD-GG 277
T + G+ + CR G P P I W N + + +G N +L N++ D
Sbjct: 149 ITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTRE 208
Query: 278 PYVCRA----------------------------------TNKAGEDEKQAFLQVFVQPH 303
Y+C A T G + F+ P
Sbjct: 209 DYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPE 268
Query: 304 IIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS 363
N+ ++L C AEG P P I W + + + + ++
Sbjct: 269 -GNASNKEELRGNVLSLECIAEGLPTPIIYWAK----------EDGMLPKNRTVYKNFEK 317
Query: 364 SLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCD 423
+L I V +DSG Y C A + +G ++ + ++ AP +I+ G + C
Sbjct: 318 TLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICR 377
Query: 424 VKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKM---ILEIAPTSDNDFGRYNCTATNH 480
NP I W + + + + RK+ + + + Y C A+N
Sbjct: 378 ANGNPKPRISWLTNGVPI------EIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNE 431
Query: 481 IGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKP 519
G Y+LA A V +I+ + T +V N+P
Sbjct: 432 YG-----YLLANAFVNVLAEPPRILTPANTLYQVIANRP 465
Score = 58.9 bits (141), Expect = 2e-08
Identities = 68/275 (24%), Positives = 111/275 (40%), Gaps = 29/275 (10%)
Query: 543 KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQ 602
KI+ G +T +L LEP + Y + V VNGKG+G S +F T +P S+
Sbjct: 886 KILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIV 945
Query: 603 PSSGKSFKLSITKQDDGGAPILEYIVKYR---SKDKEDQWLEKKVQGNKDHIILEHLQWT 659
+ S L + EY +KY+ S + ++ K+ NK L++L ++
Sbjct: 946 NPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFS 1005
Query: 660 MGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVT 719
Y+ A G S + E ++ + + G IGL A LLIL++
Sbjct: 1006 TRYKFYFYAQTSAG-SGSQITEEAVTTVDEAMASRQVDIATQGWFIGLMCAVALLILIL- 1063
Query: 720 DVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERV 779
L++C RR G KE E+ A D +P+ E
Sbjct: 1064 -----------LIVCFIRR----NKGGKYPVKEKEDAHA----DPEIQPMKEDDGTFGEY 1104
Query: 780 TNHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEAL 814
++ ED P+ + + T P +K+ED ++L
Sbjct: 1105 SDAEDHKPLKKGSRT-----PSDRTVKKEDSDDSL 1134
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 160 bits (406), Expect = 3e-39
Identities = 166/685 (24%), Positives = 288/685 (42%), Gaps = 54/685 (7%)
Query: 22 QVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIIS-----TQRVVVQKEGVRS 76
++ + S+ +S E C G P + + I+ +++ + V S
Sbjct: 408 KIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVS 467
Query: 77 RLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQ-KLTFREVVSPQEFKQ-----GE 130
L I ++ + D G+YRC A ++ G + +YQ ++ R S + K G
Sbjct: 468 YLNISSSQVRDGGVYRCTANNSAG--------VVLYQARINVRGPASIRPMKNITAIAGR 519
Query: 131 DAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKS-DEGIYRCEGR 189
D + CRV P ++ W Y N + + + A N L++ ++ K DEG Y C
Sbjct: 520 DTYIHCRVIGYPYYSIKW-YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVL 578
Query: 190 VEARGEIDFRDIIVIVNVPPAI---SMPQKSFNATAERGEEMTFSC-RASGSPEPAISWF 245
V+ + + + V V VPP I P+ S G+ + C SG I+W
Sbjct: 579 VQPQLSTS-QSVHVTVKVPPFIQPFEFPRFSI------GQRVFIPCVVVSGDLPITITWQ 631
Query: 246 RNGKLIEENEKYILKGSN--TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP- 302
++G+ I + + + + L + N+ G Y C A N+A E Q+ L V V P
Sbjct: 632 KDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPK 691
Query: 303 HIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGS 362
++Q +++ V L C AEG P+P I WK + +L+GRI+V +
Sbjct: 692 FVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL---SN 748
Query: 363 SSLHIKDVKLSDSGRYDCEAASRIGGH-QKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
SL IK V DSG Y C+ ++ +G KSMYL ++ S + +G +S
Sbjct: 749 GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMS 808
Query: 422 CDVKSNPPASIHW-RRDKLVLPAKNTTNLKTYSTGRKMI--LEIAPTSDNDFGRYNCTAT 478
C P + W + D+++ P + T G ++I L+I PT D G ++C A
Sbjct: 809 CTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAI 868
Query: 479 NHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVA 538
N G + I P P ++I ++ T + + G PI Y ++ K +
Sbjct: 869 NSYG-EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTM-GFDGNSPITGYDIECKNKS 926
Query: 539 SEIWKIVRSHGVQTMV---VLNNLEPNTTYEIRVAAVNGKGQGDYS-KIEIFQTLPVREP 594
R+ V + + ++ P++TY IR+ A N G+ + S ++ I +
Sbjct: 927 DSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDG 986
Query: 595 SPPSIHGQPSSGKSFKLS--ITKQDDGGAPILEYIVKYRSKDKEDQW----LEKKVQGNK 648
P +H +P S +S +++ K+ I Y + YR + + G+
Sbjct: 987 PPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDS 1046
Query: 649 DHIILEHLQWTMGYEVQITAANRLG 673
+ L++L Y + + A NR G
Sbjct: 1047 EVYTLDNLNKFTQYGLVVQACNRAG 1071
Score = 144 bits (363), Expect = 3e-34
Identities = 169/705 (23%), Positives = 279/705 (39%), Gaps = 93/705 (13%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLT 79
L+ TIS KV+ SVG +C+ G E + + WY GE + + V + G+
Sbjct: 314 LKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYR-NGEILNPGKNVRIT--GINHENL 370
Query: 80 IYNANIE-DAGIYRCQATDAKGQTQE-ATVVLE-----IYQKLTFREVVSPQEFKQGEDA 132
I + ++ D G Y+C K Q+ VVLE I + +VVSP E
Sbjct: 371 IMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFS-EKVVSP-----AEPV 424
Query: 133 EVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLAN---NNLQILNINKS---DEGIYRC 186
++C V +P P ++W ++ + +R + + N + LNI+ S D G+YRC
Sbjct: 425 SLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRC 484
Query: 187 EGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFR 246
A G + ++ I + PA P K N TA G + CR G P +I W++
Sbjct: 485 TANNSA-GVVLYQARINVRG--PASIRPMK--NITAIAGRDTYIHCRVIGYPYYSIKWYK 539
Query: 247 NGKLIEENEKYILKGSNTELTVRNIINS-DGGPYVCRATNKAGEDEKQAFLQVFVQPHII 305
N L+ N + + +N L + ++ D G Y C + Q+ P I
Sbjct: 540 NSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFI 599
Query: 306 QLKNETTYENGQ-VTLVCDAEGEPIP-EITWKRAVDGFTFTEGDKSLDGRIEVKGQH--G 361
Q + GQ V + C +P ITW++ DG + + G + V +
Sbjct: 600 QPFEFPRFSIGQRVFIPCVVVSGDLPITITWQK--DG-------RPIPGSLGVTIDNIDF 650
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
+SSL I ++ L +G Y C A + + L + PKF+ G + ++
Sbjct: 651 TSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILN 710
Query: 422 CDVKSNPPASIHWRRDK-----LVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCT 476
C + P +I W+ K P ++ S G +I + + D G Y C
Sbjct: 711 CSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVV---EEDSGYYLCK 767
Query: 477 ATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPD----SHGGVPI----- 527
+N +G + + +P+ I TT K + +HG PI
Sbjct: 768 VSNDVGADVSKSMYLTVKIPAM-----ITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWE 822
Query: 528 ----------HHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQ 577
Y V KEV E+ + T+ +L + ++ + A+N G+
Sbjct: 823 KEDRIINPEMARYLVSTKEVGEEV--------ISTLQILPTVREDSGF-FSCHAINSYGE 873
Query: 578 GDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKED 637
I Q P PP I + ++ L T DG +PI Y ++ K+K D
Sbjct: 874 DR----GIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIE--CKNKSD 927
Query: 638 QW----LEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
W K V + + + + Y +++ A NR+G SEP+
Sbjct: 928 SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS 972
Score = 114 bits (285), Expect = 4e-25
Identities = 179/722 (24%), Positives = 293/722 (40%), Gaps = 101/722 (13%)
Query: 15 SSGQALLQVTIS---------LSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIIST 64
S+G L Q I+ + + G + C IG P SI WY +
Sbjct: 489 SAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNH 548
Query: 65 QRVVVQKEGVRSRLTIYNANIE-DAGIYRC----QATDAKGQTQEATVVLEIYQKLTFRE 119
++V + G L + + E D G Y C Q + Q+ TV + +
Sbjct: 549 RQVAFENNGT---LKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPF------- 598
Query: 120 VVSPQEFKQ---GEDAEVVCRVSSSPAP-AVSWLYHNEEV-----TTISDNRFAMLANNN 170
+ P EF + G+ + C V S P ++W + TI + F ++
Sbjct: 599 -IQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFT----SS 653
Query: 171 LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTF 230
L+I N++ G Y C R EA ++ + + IV VPP + + + G+ +
Sbjct: 654 LRISNLSLMHNGNYTCIARNEAAA-VEHQSQL-IVRVPPKFVVQPRDQDGIY--GKAVIL 709
Query: 231 SCRASGSPEPAISW-FRNGKLIEENEKYILKG-----SNTELTVRNIINSDGGPYVCRAT 284
+C A G P P I W F G + + + L G SN L +++++ D G Y+C+ +
Sbjct: 710 NCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVS 769
Query: 285 NKAGED-EKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAVDGFT 342
N G D K +L V + I N T GQ + C A GE + W++ D
Sbjct: 770 NDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKE-DRII 828
Query: 343 FTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP- 401
E + L EV G+ S+L I DSG + C A + G + + L ++ P
Sbjct: 829 NPEMARYLVSTKEV-GEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 887
Query: 402 ------KFISNQTIYYSW----EGN-PI---NISCDVKSNPPASIHWRRDKLVLPAKNTT 447
K + +TI W +GN PI +I C KS+ S +R K V P N+
Sbjct: 888 PPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSA--QRTKDVSPQLNSA 945
Query: 448 NLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG----VK 503
I++I P+S Y A N IG L + ++P G V
Sbjct: 946 T----------IIDIHPSSTYSIRMY---AKNRIGKSEPSNELTITADEAAPDGPPQEVH 992
Query: 504 IIELSQTTAKVSFNKPDSH--GGVPIHHYQVDVKEVASE---IWKI--VRSHGVQTMVVL 556
+ +S + +V++ P H G+ I YQ+ +E ++ + I V + G + L
Sbjct: 993 LEPISSQSIRVTWKAPKKHLQNGI-IRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTL 1051
Query: 557 NNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTL-PVREPSPPSIHGQPSSGKSFKLS--- 612
+NL T Y + V A N G G S+ I TL V P ++ +S +S +S
Sbjct: 1052 DNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWST 1111
Query: 613 ITKQDDGGAPILEYIVKYRSKDKEDQWLE-KKVQGNKDHIILEHLQWTMGYEVQITAANR 671
++K+ G + + V Y + + + E K + + + L+ L+ Y +Q+ A R
Sbjct: 1112 LSKEALNGI-LQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTR 1170
Query: 672 LG 673
G
Sbjct: 1171 AG 1172
Score = 102 bits (254), Expect = 1e-21
Identities = 122/484 (25%), Positives = 194/484 (40%), Gaps = 35/484 (7%)
Query: 19 ALLQVTISLSKVELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRVV-VQKEGVRS 76
+L V SL +V + C A G P ++ WY GE+I + V G
Sbjct: 23 SLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQ 82
Query: 77 RLTI----YNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDA 132
++ I D Y C A + G+ + V ++ + + V Q+ +G A
Sbjct: 83 IFPFPPSSFSTLIHD-NTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVA 141
Query: 133 EVVCRVSSSPAP---AVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIY--RCE 187
C + SS VSW + V+ +S +RF + + L I ++ D G+Y RC
Sbjct: 142 VFKCIIPSSVEAYITVVSW--EKDTVSLVSGSRFLITSTGALYIKDVQNED-GLYNYRCI 198
Query: 188 GRVEARGEIDFRDIIVIVNVPPAISMPQ--KSFN-ATAERGEEMTFSCRASGSPEPAISW 244
R GE + + PA S P F+ A G+ + C+A G PEP W
Sbjct: 199 TRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRW 258
Query: 245 FRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP-- 302
++ +E + ++ + + T L + NI SD G YVC +N+ G + L V QP
Sbjct: 259 LKDNMPLELSGRF--QKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV-KQPLK 315
Query: 303 HIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGS 362
I + + QV+L C G E++W R +G G + + G +
Sbjct: 316 ATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYR--NGEILNPGK-----NVRITGINHE 368
Query: 363 SSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE-YAPKFISNQTIYYSWEGNPINIS 421
+ + VK SD G Y C Q + + +E PK IS + P+++
Sbjct: 369 NLIMDHMVK-SDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLM 427
Query: 422 CDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMI---LEIAPTSDNDFGRYNCTAT 478
C+VK P +I W D + + + T + L I+ + D G Y CTA
Sbjct: 428 CNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTAN 487
Query: 479 NHIG 482
N G
Sbjct: 488 NSAG 491
Score = 95.1 bits (235), Expect = 2e-19
Identities = 90/356 (25%), Positives = 150/356 (42%), Gaps = 28/356 (7%)
Query: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCE- 187
G+ E+ C+ P P WL N + RF L I NI SD G Y CE
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLEL--SGRFQKTVTG-LLIENIRPSDSGSYVCEV 295
Query: 188 ----GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS 243
G + G + + + A P+K ++ G +++ SC +G+ + +S
Sbjct: 296 SNRYGTAKVIGRLYVKQPL------KATISPRKVKSSV---GSQVSLSCSVTGTEDQELS 346
Query: 244 WFRNGKLIEENEKYILKGSNTE-LTVRNIINSDGGPYVC--RATNKAGEDEKQAFLQVFV 300
W+RNG+++ + + G N E L + +++ SDGG Y C R + +D Q L+
Sbjct: 347 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT 406
Query: 301 QPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQ 359
P II +E + V+L+C+ +G P+P ITW +D +G ++
Sbjct: 407 -PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--TLDDDPILKGGSHRISQMITSEG 463
Query: 360 HGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPIN 419
+ S L+I ++ D G Y C A + G +++ P I + G
Sbjct: 464 NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRPMKNITAIAGRDTY 522
Query: 420 ISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNC 475
I C V P SI W ++ +LP N + + G + ++ + D G Y C
Sbjct: 523 IHCRVIGYPYYSIKWYKNSNLLPF-NHRQVAFENNGTLKLSDV--QKEVDEGEYTC 575
Score = 86.3 bits (212), Expect = 1e-16
Identities = 147/626 (23%), Positives = 236/626 (37%), Gaps = 100/626 (15%)
Query: 33 SVGESKFFTCTAIGE--PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGI 90
S+G+ F C + P +I W G I + V + S L I N ++ G
Sbjct: 608 SIGQRVFIPCVVVSGDLPITITWQK-DGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGN 666
Query: 91 YRCQA-TDAKGQTQEATVVLEIYQKLTFREVVSP--QEFKQGEDAEVVCRVSSSPAPAVS 147
Y C A +A ++ +++ + K VV P Q+ G+ + C P P +
Sbjct: 667 YTCIARNEAAAVEHQSQLIVRVPPKF----VVQPRDQDGIYGKAVILNCSAEGYPVPTIV 722
Query: 148 WLYHN----EEVTTISDN-RFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDII 202
W + + I+ N R +L+N +L I ++ + D G Y C+ + ++ + +
Sbjct: 723 WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVS-KSMY 781
Query: 203 VIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIE-ENEKYILKG 261
+ V +P I+ + AT +G++ SC A G + W + ++I E +Y++
Sbjct: 782 LTVKIPAMITSYPNTTLAT--QGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVST 839
Query: 262 SN------TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQ----PHIIQLKNET 311
+ L + + D G + C A N GED + +Q+ VQ P I++K
Sbjct: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGED--RGIIQLTVQEPPDPPEIEIK--- 894
Query: 312 TYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVK 371
D + I + W DG + G D + K S+ KDV
Sbjct: 895 -----------DVKARTIT-LRWTMGFDGNSPITG---YDIECKNKSDSWDSAQRTKDVS 939
Query: 372 LSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCD--VKSNPP 429
+A+ I H S Y YA I S N + I+ D PP
Sbjct: 940 PQ------LNSATIIDIHPSSTYSIRMYAKNRIGK-----SEPSNELTITADEAAPDGPP 988
Query: 430 ASIHWR-------RDKLVLPAKNTTN---------LKTYSTGRKM---ILEIAPTSD--- 467
+H R P K+ N + YSTG I+ + + D
Sbjct: 989 QEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEV 1048
Query: 468 ------NDFGRYNCT--ATNHIGT--RFQEYILA-LADVPS-SPYGVKIIELSQTTAKVS 515
N F +Y A N GT QE I L DVPS P V+ I S + +S
Sbjct: 1049 YTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISIS 1108
Query: 516 FN---KPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAV 572
++ K +G + + E+ +I Q + L+ LE T Y I+V A
Sbjct: 1109 WSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168
Query: 573 NGKGQGDYSKIEIFQTLPVREPSPPS 598
G G S+ +IF P PP+
Sbjct: 1169 TRAGDGVRSE-QIFTRTKEDVPGPPA 1193
Score = 71.6 bits (174), Expect = 3e-12
Identities = 86/350 (24%), Positives = 144/350 (41%), Gaps = 28/350 (8%)
Query: 418 INISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILE-----IAPTSDNDFGR 472
I + C +P ++ W +D P+ T + GR+ I I D G
Sbjct: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTID------GRRSIFSNGSFIIRTVKAEDSGY 1356
Query: 473 YNCTATNHIGTRFQEYILAL-ADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQ 531
Y+C A N+ G+ E IL L VP + + + + ++ +S+ P +GG I Y
Sbjct: 1357 YSCIANNNWGS--DEIILNLQVQVPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYI 1413
Query: 532 VDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPV 591
+ E SE W + L NL+ T Y+ + A NG G G S+I +TL
Sbjct: 1414 LQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLG- 1472
Query: 592 REP--SPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD 649
+EP S + +L++ +DGG PI + ++YR ++ +K
Sbjct: 1473 KEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKS 1532
Query: 650 HIILEHLQWTMGYEVQITAANRLGYSEP----TVYEFSMPPKPNIIKDTLFNGLGLGAVI 705
+I+ + LQ YE+Q+ N G +E + P +IK + N GL
Sbjct: 1533 YILYD-LQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNE 1591
Query: 706 GLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEE 755
GL + + ++V + F LL+ + RR ++ +K L E
Sbjct: 1592 GLKMLVTISCILVGVLLLFV-----LLLVVRRRRREQRLKRLRDAKSLAE 1636
Score = 55.1 bits (131), Expect = 3e-07
Identities = 59/273 (21%), Positives = 107/273 (39%), Gaps = 34/273 (12%)
Query: 318 VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGR 377
+ L C A G+P P + W + +G T ++DGR + + S I+ VK DSG
Sbjct: 1303 IVLPCKAVGDPSPAVKWMKDSNG---TPSLVTIDGRRSI---FSNGSFIIRTVKAEDSGY 1356
Query: 378 YDCEAASRIGGHQKSMYLDIEYAP-------KFISNQTIYYSW----EGNPINISCDVKS 426
Y C A + G + + L ++ P ++ +I SW G ++
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQY 1416
Query: 427 NPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQ 486
+ S W + P++ + L+ G + ++ TA N +G
Sbjct: 1417 SEDNSEQWGSFP-ISPSERSYRLENLKCG-------------TWYKFTLTAQNGVGPGRI 1462
Query: 487 EYILALADVPSSPYGVKIIEL--SQTTAKVSFNKPD-SHGGVPIHHYQVDVKEVASEIWK 543
I+ + P K EL S T +V N + GG PI + ++ + + +W
Sbjct: 1463 SEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWT 1522
Query: 544 IVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKG 576
+ + +L +L+ T YE+++ N G
Sbjct: 1523 TAQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
Score = 44.7 bits (104), Expect = 4e-04
Identities = 31/108 (28%), Positives = 45/108 (41%), Gaps = 11/108 (10%)
Query: 204 IVNVPPAISMPQK----SFNATAERGEEMTFSCRASGSPEPAISWFRNGK-----LIEEN 254
I+ V P P + S T +++ C+A G P PA+ W ++ + +
Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDG 1334
Query: 255 EKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
+ I SN +R + D G Y C A N G DE LQV V P
Sbjct: 1335 RRSIF--SNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
Score = 34.7 bits (78), Expect = 0.38
Identities = 20/74 (27%), Positives = 33/74 (44%), Gaps = 5/74 (6%)
Query: 115 LTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTI--SDNRFAMLANNNLQ 172
LTF V+ K D + C+ P+PAV W+ + ++ D R ++ +N +
Sbjct: 1289 LTFSGTVTTPWMK---DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI 1345
Query: 173 ILNINKSDEGIYRC 186
I + D G Y C
Sbjct: 1346 IRTVKAEDSGYYSC 1359
Score = 32.3 bits (72), Expect = 1.9
Identities = 26/90 (28%), Positives = 36/90 (40%), Gaps = 1/90 (1%)
Query: 494 DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
DVP P GVK S + VS+ P G+ I Y V + +
Sbjct: 1187 DVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASPDSFS 1245
Query: 554 VVLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
+ NL N Y + V AV G+G+ S+I
Sbjct: 1246 YRIPNLSRNRQYSVWVVAVTSAGRGNSSEI 1275
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 153 bits (387), Expect = 6e-37
Identities = 147/584 (25%), Positives = 247/584 (42%), Gaps = 52/584 (8%)
Query: 122 SPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLA-NNNLQILNINKSD 180
S +E +G + C P P + W +E + NR LQI++++++D
Sbjct: 278 SNKEELRGNVLSLECIAEGLPTPIIYWA---KEDGMLPKNRTVYKNFEKTLQIIHVSEAD 334
Query: 181 EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP 240
G Y+C + A G I + + P I+ PQ N GE+ T CRA+G+P+P
Sbjct: 335 SGNYQCIAK-NALGAIHHTISVRVKAAPYWITAPQ---NLVLSPGEDGTLICRANGNPKP 390
Query: 241 AISWFRNGKLIE-ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVF 299
ISW NG IE + K + N+ Y C A+N+ G AF+ V
Sbjct: 391 RISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL 450
Query: 300 VQPHIIQLKNETTYE---NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEV 356
+P I T Y+ N L C G P+P I W + G E ++
Sbjct: 451 AEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHE---------DI 501
Query: 357 KGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIY-YSWEG 415
H + +L I + +G Y C A +++G + ++L+I+ P +I Q Y G
Sbjct: 502 YVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK-DPTWIVKQPEYAVVQRG 560
Query: 416 NPINISCDVKSNPPAS--IHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
+ ++ C VK + S + W +D LP+ T K L +A SD+D G Y
Sbjct: 561 SMVSFECKVKHDHTLSLTVLWLKDNRELPSDER------FTVDKDHLVVADVSDDDSGTY 614
Query: 474 NCTATNHIGTRFQEYILALA----------DVPSSPYGVKIIELSQTTAKVSFNKPDSHG 523
C A + + +L++ DVP+ P+ +++ + + ++S+ D +
Sbjct: 615 TCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNN 674
Query: 524 GVPIHHYQVDVKEVASE--IW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDY 580
PI + ++ ++ + +W G QT L L P Y RV AVN G+
Sbjct: 675 S-PITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLP 732
Query: 581 SKIEIFQTLPVREP--SPPSIHGQPSSGKSFKLSITKQD--DGGAPILEYIVKYRSKDKE 636
S+ EP +P ++ G S + ++ + + P L+Y V +R KD +
Sbjct: 733 SEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGD 792
Query: 637 DQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYS-EPTV 679
D+W V N I+ + Y +++ A N +G++ EP V
Sbjct: 793 DEW-TSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAV 835
Score = 97.1 bits (240), Expect = 6e-20
Identities = 152/701 (21%), Positives = 259/701 (36%), Gaps = 87/701 (12%)
Query: 36 ESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA-----G 89
E+ C A G+P S W I +V K G + I N E G
Sbjct: 62 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGT--LIINIMSEGKAETYEG 119
Query: 90 IYRCQATDAKGQTQEATVVLEIYQK-LTFREVVSPQEFKQGEDAEVVCRVSSS-PAPAVS 147
+Y+C A + +G +V+ + L +E + P + G+ + CR P P +
Sbjct: 120 VYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIF 179
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSD-EGIYRCEGRVEARGEIDFRDIIVIVN 206
W+ ++ + S+ R + N +L N+ D Y C R I + I +
Sbjct: 180 WMDNSFQRLPQSE-RVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKV 238
Query: 207 V---------------------------PPAISMPQKSFNATAE-RGEEMTFSCRASGSP 238
+ PP P+ + + E RG ++ C A G P
Sbjct: 239 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 298
Query: 239 EPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV 298
P I W + ++ +N + + K L + ++ +D G Y C A N G ++V
Sbjct: 299 TPIIYWAKEDGMLPKN-RTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRV 357
Query: 299 FVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKS--LDGRIE 355
P+ I G+ TL+C A G P P I+W D S +DG
Sbjct: 358 KAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDG--- 414
Query: 356 VKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISN--QTIYYSW 413
++ +V+ S Y C A++ G + ++++ P I T+Y
Sbjct: 415 -------DTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVI 467
Query: 414 EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTT-NLKTYSTGRKMILEIAPTSDNDFGR 472
P + C +P +I W + AK + + Y LEI + G
Sbjct: 468 ANRPALLDCAFFGSPLPTIEWFKG-----AKGSALHEDIYVLHENGTLEIPVAQKDSTGT 522
Query: 473 YNCTATNHIGTRFQEYILALAD----VPSSPYGVKIIELSQTTAKVSFN---KPDSHGGV 525
Y C A N +G E L + D V Y V Q + VSF K D +
Sbjct: 523 YTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAV-----VQRGSMVSFECKVKHDHTLSL 577
Query: 526 PIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI 585
+ + + + + E + + + H +VV + + ++ VA + + +
Sbjct: 578 TVLWLKDNRELPSDERFTVDKDH----LVVADVSDDDSGTYTCVANTTLDSVSASAVLSV 633
Query: 586 FQTLPVRE-----PSPP-SIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYR-SKDKEDQ 638
P P+PP + KS +LS T DD +PI ++I++Y + K
Sbjct: 634 VAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGL 693
Query: 639 W-LEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPT 678
W + +V G + L+ L + Y ++ A N +G S P+
Sbjct: 694 WHHQTEVSGTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPS 733
Score = 72.4 bits (176), Expect = 2e-12
Identities = 98/476 (20%), Positives = 171/476 (35%), Gaps = 71/476 (14%)
Query: 90 IYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEF--KQGEDAEVVCRVSSSPAPAVS 147
++ CQ A + ++ ++ Q T + SP+++ E+ + C P P+ S
Sbjct: 21 LFLCQMISALEVPLDPKLLEDLVQPPTITQQ-SPKDYIIDPRENIVIQCEAKGKPPPSFS 79
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNI-----NKSDEGIYRCEGRVEARGEIDFRDII 202
W + D M I+NI ++ EG+Y+C R E RG +I+
Sbjct: 80 WTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNE-RGAAVSNNIV 138
Query: 203 VIVNVPPAISMPQKSFNATAERGEEMTFSCRAS-GSPEPAISWFRNGKLIEENEKYILKG 261
V + P + +K T + G+ + CR G P P I W N + + +G
Sbjct: 139 VRPSRSP-LWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQG 197
Query: 262 SNTELTVRNIINSD-GGPYVCRA----------------------------------TNK 286
N +L N++ D Y+C A T
Sbjct: 198 LNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEF 257
Query: 287 AGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEG 346
G + F+ P N+ ++L C AEG P P I W +
Sbjct: 258 YGAKSSRERPPTFLTPE-GNASNKEELRGNVLSLECIAEGLPTPIIYWAK---------- 306
Query: 347 DKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISN 406
+ + + ++ +L I V +DSG Y C A + +G ++ + ++ AP +I+
Sbjct: 307 EDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITA 366
Query: 407 QTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKM---ILEIA 463
G + C NP I W + + + + RK+ + +
Sbjct: 367 PQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPI------EIAPDDPSRKIDGDTIIFS 420
Query: 464 PTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKP 519
+ Y C A+N G Y+LA A V +I+ + T +V N+P
Sbjct: 421 NVQERSSAVYQCNASNEYG-----YLLANAFVNVLAEPPRILTPANTLYQVIANRP 471
Score = 47.4 bits (111), Expect = 6e-05
Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 49/337 (14%)
Query: 495 VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVAS--EIWKIV--RSHGV 550
VPS+P +KI+ + + + ++ P G+ + Y + + + S E+ +V +
Sbjct: 951 VPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTLKYQPINSTHELGPLVDLKIPAN 1009
Query: 551 QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFK 610
+T L NL +T Y+ A G G E T+ PP + + +
Sbjct: 1010 KTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPR 1069
Query: 611 LS------------ITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQW 658
+S I+ + +G + + V+Y +++W ++ V G++ L+ L
Sbjct: 1070 ISNLTAAAAETYANISWEYEGPEHV-NFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMP 1128
Query: 659 TMGYEVQITAANRLGY-SEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILV 717
Y+V++ A G+ S V+E + P + D G IGL A LLIL+
Sbjct: 1129 GTAYKVRVGAVGDSGFVSSEDVFE-TGPAMASRQVDIATQGW----FIGLMCAVALLILI 1183
Query: 718 VTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDE 777
+ L++C RR G KE E+ A D +P+ E
Sbjct: 1184 L------------LIVCFIRR----NKGGKYPVKEKEDAHA----DPEIQPMKEDDGTFG 1223
Query: 778 RVTNHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEAL 814
++ ED P+ + + T P +K+ED ++L
Sbjct: 1224 EYSDAEDHKPLKKGSRT-----PSDRTVKKEDSDDSL 1255
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 3/134 (2%)
Query: 543 KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQ 602
KI+ G +T +L LEP + Y + V VNGKG+G S +F T +P S+
Sbjct: 902 KILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIV 961
Query: 603 PSSGKSFKLSITKQDDGGAPILEYIVKYR---SKDKEDQWLEKKVQGNKDHIILEHLQWT 659
+ S L + EY +KY+ S + ++ K+ NK L++L ++
Sbjct: 962 NPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFS 1021
Query: 660 MGYEVQITAANRLG 673
Y+ A G
Sbjct: 1022 TRYKFYFYAQTSAG 1035
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 151 bits (381), Expect = 3e-36
Identities = 136/475 (28%), Positives = 201/475 (42%), Gaps = 32/475 (6%)
Query: 30 VELSVGESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V +S GE+ +C +GE P ++ W ST RV + L I D
Sbjct: 409 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD---LSLEISGIIPTDG 465
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSW 148
G Y+C A++A G T+ A+V L + + S Q F QG + +V C S P P +SW
Sbjct: 466 GRYQCVASNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW 524
Query: 149 LYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVP 208
E D+R + A L I + D G Y C+ E D + + P
Sbjct: 525 --SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV--GTDQETVTLYYTDP 580
Query: 209 PAISMPQKSFNAT--AERGEEMTFSCRASGSPEPAISWFRNG-KLIEENEKYILKGSNTE 265
P++S + NA GEE C ASG P P + W+R G ++I E S+ +
Sbjct: 581 PSVS----AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE----GSSSGK 632
Query: 266 LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDA 324
L + D G Y CRA N+ G+ + L V P + +L + T E G+ L C A
Sbjct: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRA 692
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
G P P +TW+R DG G + GR Q S L + V D Y CEA +
Sbjct: 693 TGRPPPTVTWRRG-DGQPL--GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 749
Query: 385 RIGGHQKSMYLDI--EYAPKFISNQTIYYSWEGNPINISCDVKSNPP-ASIHWRRDKLVL 441
G Q L + P+ S+ EG P+++ C V + P HW +D L
Sbjct: 750 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 809
Query: 442 PAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
P + +++ + L + GRY+C ATN G++ ++ L + P
Sbjct: 810 PPGSRHSIRADGS-----LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
Score = 145 bits (365), Expect = 2e-34
Identities = 131/485 (27%), Positives = 196/485 (40%), Gaps = 36/485 (7%)
Query: 22 QVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIY 81
QV+I S S G +C+A G P ++ + + + R+ V +G L I
Sbjct: 492 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQ 548
Query: 82 NANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSS 141
EDAG Y CQAT+ G QE TV L + V + GE+A +VC S
Sbjct: 549 GVAPEDAGNYSCQATNEVGTDQE-TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGV 607
Query: 142 PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDI 201
P P V W E+ + ++ L+I + D G Y C V G+
Sbjct: 608 PPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCRA-VNELGDASAEIQ 662
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG 261
+ + + P +P+ + T E G +CRA+G P P ++W R +G
Sbjct: 663 LAVGHAPQLTELPR---DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG 719
Query: 262 SNTE------LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV--FVQPHIIQLKNETTY 313
S + L ++ D PYVC A N G+ + +A L V P I
Sbjct: 720 SRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV 779
Query: 314 ENGQ-VTLVCDA-EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVK 371
GQ V+L C G P+PE W + DG G + SLH+
Sbjct: 780 LEGQPVSLPCIVLAGRPLPERHWLK--DGRPLPPGSRH--------SIRADGSLHLDRAL 829
Query: 372 LSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPAS 431
+GRY C A + G + + L ++ P+ T + + EG P ++ C P +
Sbjct: 830 QEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 889
Query: 432 IHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILA 491
I W ++ L T+ Y+ ++ L IA S D G Y CTATN +G QE L+
Sbjct: 890 ITWTKETNAL----TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLS 945
Query: 492 LADVP 496
+ P
Sbjct: 946 VNTKP 950
Score = 127 bits (319), Expect = 4e-29
Identities = 121/484 (25%), Positives = 193/484 (39%), Gaps = 50/484 (10%)
Query: 30 VELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRS-RLTIYNANIED 87
V ++VGE C A G P + WY E I++ EG S +L I A D
Sbjct: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP-------EGSSSGKLRIPAAQERD 642
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
AG Y C+A + G A + L + E+ + G A + CR + P P V+
Sbjct: 643 AGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 701
Query: 148 WLYHNEEVTTIS-----DNRFAMLANNNLQILNINKSDEGIYRCEGR-VEARGEIDFRDI 201
W + + + +R + L ++ D+ Y CE R V + + + R +
Sbjct: 702 WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEAR-L 760
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRA-SGSPEPAISWFRNGKLIEENEKYILK 260
IV + PP I+ + G+ ++ C +G P P W ++G+ + ++ ++
Sbjct: 761 IVTGHAPPQIASSAPTVRVL--EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR 818
Query: 261 GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLK-NETTYENGQVT 319
+ L + + G Y C ATN AG + L V V P I + T E +
Sbjct: 819 ADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPAS 877
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSS----LHIKDVKLSDS 375
L C A G P P ITW + + T +G H + S L I D+
Sbjct: 878 LPCVASGVPAPTITWTKETNALTS-------------RGPHYNVSKEGTLLIAQPSAQDA 924
Query: 376 GRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI-------YYSWEGNPINISCDVKSNP 428
G Y C A + +G + M L + P+ N + + G + + C+ K +P
Sbjct: 925 GAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984
Query: 429 PASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
P + W +D +P TN Y L +A D G Y CTA+N G+ Y
Sbjct: 985 PPLVTWTKDSRPVPP--ITN--RYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRY 1040
Query: 489 ILAL 492
+L +
Sbjct: 1041 VLGV 1044
Score = 119 bits (298), Expect = 1e-26
Identities = 88/340 (25%), Positives = 146/340 (42%), Gaps = 26/340 (7%)
Query: 160 DNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFN 219
+ F N++ +IL +K++EG Y C V G + IV+ + PP + +P N
Sbjct: 353 ERHFQESGNSSWEILRASKAEEGTYECTA-VSRAGTGRAKAQIVVTDPPPQL-VPAP--N 408
Query: 220 ATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPY 279
T GE SCR G ++W R+ +++ + + + ++ L + II +DGG Y
Sbjct: 409 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 468
Query: 280 VCRATNKAGEDEKQAFLQVFVQPHI-IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAV 338
C A+N G +L V P + I ++ + +V + C A G P P I+W R
Sbjct: 469 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 528
Query: 339 DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
D RI V Q +L I+ V D+G Y C+A + +G Q+++ L
Sbjct: 529 QAL-------QEDSRIHVDAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 578
Query: 399 YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD--KLVLPAKNTTNLKTYSTGR 456
P + + G + C+ PP + W R +++L + +++ K
Sbjct: 579 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK------ 632
Query: 457 KMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
L I + D G Y C A N +G E LA+ P
Sbjct: 633 ---LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 669
Score = 102 bits (255), Expect = 1e-21
Identities = 96/391 (24%), Positives = 158/391 (40%), Gaps = 29/391 (7%)
Query: 22 QVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKI---ISTQRVVVQKEGVRSR 77
Q+T V + +G S C A G P ++ W G+ + + R ++
Sbjct: 670 QLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV 729
Query: 78 LTIYNANIEDAGIYRCQATDAKGQTQ-EATVVLEIYQKLTFREVVSPQEFKQGEDAEVVC 136
L + ED Y C+A + G+ Q EA +++ + +G+ + C
Sbjct: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPC 789
Query: 137 RV-SSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
V + P P WL + S R ++ A+ +L + + G Y C A +
Sbjct: 790 IVLAGRPLPERHWLKDGRPLPPGS--RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ 847
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE 255
RD+ ++V VPP I P + + T E G + C ASG P P I+W + +
Sbjct: 848 --HRDVELVVQVPPRIH-PTATHHITNE-GVPASLPCVASGVPAPTITWTKETNALTSRG 903
Query: 256 KYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI-------IQLK 308
+ L + D G YVC ATN G ++ L V +P I +
Sbjct: 904 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVP 963
Query: 309 NETTYENG-QVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHI 367
+ T + G +VTL C+A+G P P +TW T+ + + G S SL +
Sbjct: 964 LQVTAKAGEEVTLDCEAKGSPPPLVTW---------TKDSRPVPPITNRYGLLPSGSLRL 1014
Query: 368 KDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
V++ DSG Y+C A++ G L ++
Sbjct: 1015 AQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
Score = 82.8 bits (203), Expect = 1e-15
Identities = 63/253 (24%), Positives = 105/253 (41%), Gaps = 15/253 (5%)
Query: 246 RNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVF-VQPHI 304
R G+ E++ + N+ + ++ G Y C A ++AG +A + V P +
Sbjct: 344 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 403
Query: 305 IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSS 364
+ N T L C GE +TW R + G + Q S
Sbjct: 404 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA---------QLADLS 454
Query: 365 LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDV 424
L I + +D GRY C A++ G + S++L + AP+ + + + +G + +SC
Sbjct: 455 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA 514
Query: 425 KSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
P I W R+ L + + + + G +I +AP D G Y+C ATN +GT
Sbjct: 515 SGYPTPHISWSRESQAL--QEDSRIHVDAQGTLIIQGVAP---EDAGNYSCQATNEVGTD 569
Query: 485 FQEYILALADVPS 497
+ L D PS
Sbjct: 570 QETVTLYYTDPPS 582
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 151 bits (381), Expect = 3e-36
Identities = 136/475 (28%), Positives = 201/475 (42%), Gaps = 32/475 (6%)
Query: 30 VELSVGESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V +S GE+ +C +GE P ++ W ST RV + L I D
Sbjct: 526 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD---LSLEISGIIPTDG 582
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSW 148
G Y+C A++A G T+ A+V L + + S Q F QG + +V C S P P +SW
Sbjct: 583 GRYQCVASNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW 641
Query: 149 LYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVP 208
E D+R + A L I + D G Y C+ E D + + P
Sbjct: 642 --SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV--GTDQETVTLYYTDP 697
Query: 209 PAISMPQKSFNAT--AERGEEMTFSCRASGSPEPAISWFRNG-KLIEENEKYILKGSNTE 265
P++S + NA GEE C ASG P P + W+R G ++I E S+ +
Sbjct: 698 PSVS----AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE----GSSSGK 749
Query: 266 LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDA 324
L + D G Y CRA N+ G+ + L V P + +L + T E G+ L C A
Sbjct: 750 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRA 809
Query: 325 EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAAS 384
G P P +TW+R DG G + GR Q S L + V D Y CEA +
Sbjct: 810 TGRPPPTVTWRRG-DGQPL--GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866
Query: 385 RIGGHQKSMYLDI--EYAPKFISNQTIYYSWEGNPINISCDVKSNPP-ASIHWRRDKLVL 441
G Q L + P+ S+ EG P+++ C V + P HW +D L
Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 926
Query: 442 PAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
P + +++ + L + GRY+C ATN G++ ++ L + P
Sbjct: 927 PPGSRHSIRADGS-----LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 976
Score = 147 bits (370), Expect = 5e-35
Identities = 116/412 (28%), Positives = 172/412 (41%), Gaps = 27/412 (6%)
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
AG Y C A ++ G + V L + + + S E+ + C S P P ++
Sbjct: 3922 AGRYTCSARNSAGVAHKH-VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTIT 3980
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNV 207
W V T + +L L+I + + D G Y C + A + ++V V
Sbjct: 3981 WQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV--QV 4036
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT 267
PP I + T G C+A GSPEP I+W ++G+ + E + EL
Sbjct: 4037 PPVIENGLPDLSTT--EGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELL 4094
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENG-QVTLVCDAEG 326
V+N+ D G Y C A N G ++ L + V P L + + G ++ L C A G
Sbjct: 4095 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARG 4154
Query: 327 EPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRI 386
P P I W V+ TEG V Q G S+L V DSG Y C A +R+
Sbjct: 4155 SPTPRIGW--TVNDRPVTEG---------VSEQDGGSTLQRAAVSREDSGTYVCWAENRV 4203
Query: 387 GGHQKSMYLDIEYAPKFISNQTIYYSWE--GNPINISCDVKSNPPASIHWRRDKLVLPAK 444
G Q ++ ++ AP + + Y E G I + C V+ +P IHW +D L L
Sbjct: 4204 GRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGS 4262
Query: 445 NTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ + + L I T +D GRY C A N +G + IL L P
Sbjct: 4263 HLRHQLQNGS-----LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP 4309
Score = 145 bits (367), Expect = 1e-34
Identities = 132/489 (26%), Positives = 198/489 (40%), Gaps = 36/489 (7%)
Query: 22 QVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIY 81
QV+I S S G +C+A G P ++ + + + R+ V +G L I
Sbjct: 609 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQ 665
Query: 82 NANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSS 141
EDAG Y CQAT+ G QE TV L + V + GE+A +VC S
Sbjct: 666 GVAPEDAGNYSCQATNEVGTDQE-TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGV 724
Query: 142 PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDI 201
P P V W E+ + ++ L+I + D G Y C V G+
Sbjct: 725 PPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCRA-VNELGDASAEIQ 779
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG 261
+ + + P +P+ + T E G +CRA+G P P ++W R +G
Sbjct: 780 LAVGHAPQLTELPR---DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG 836
Query: 262 SNTE------LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV--FVQPHIIQLKNETTY 313
S + L ++ D PYVC A N G+ + +A L V P I
Sbjct: 837 SRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV 896
Query: 314 ENGQ-VTLVCDA-EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVK 371
GQ V+L C G P+PE W + DG G + SLH+
Sbjct: 897 LEGQPVSLPCIVLAGRPLPERHWLK--DGRPLPPGSRH--------SIRADGSLHLDRAL 946
Query: 372 LSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPAS 431
+GRY C A + G + + L ++ P+ T + + EG P ++ C P +
Sbjct: 947 QEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT 1006
Query: 432 IHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILA 491
I W ++ L T+ Y+ ++ L IA S D G Y CTATN +G QE L+
Sbjct: 1007 ITWTKETNAL----TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLS 1062
Query: 492 LADVPSSPY 500
+ + S Y
Sbjct: 1063 VNRLALSKY 1071
Score = 144 bits (362), Expect = 4e-34
Identities = 129/500 (25%), Positives = 210/500 (42%), Gaps = 52/500 (10%)
Query: 30 VELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V + VG+ +C PE ++ WY G+ ++ QR + G RL I A + D
Sbjct: 3042 VLVRVGDKAVLSCETDALPEPTVTWYK-DGQPLVLAQRTQALRGG--QRLEIQEAQVSDK 3098
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFR----EVVSPQEFKQGEDAEVVCRVSSSPAP 144
G+Y C+ ++ G+ T L + TF E VS G + C VS PAP
Sbjct: 3099 GLYSCKVSNVAGEAVR-TFTLTVQVPPTFENPKTETVSQVA---GSPLVLTCDVSGVPAP 3154
Query: 145 AVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG---RVEARGEIDFRDI 201
V+WL V + S + LQ+ + + G Y C + EAR +D
Sbjct: 3155 TVTWLKDRMPVES-SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR-----KDF 3208
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE----KY 257
+V V V P I + G+E+ C A G P P ++W ++G + ++ ++
Sbjct: 3209 VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 3268
Query: 258 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNET----TY 313
L G + L ++ + SD G Y C A N AGED + + V V P I Q + + +
Sbjct: 3269 YLDGGS--LVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSR 3326
Query: 314 ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS-SLHIKDVKL 372
VT+VC G P ++W + DG ++L HGS +L I V+L
Sbjct: 3327 PGELVTMVCPVRGSPPIHVSWLK--DGLPLPLSQRTL--------LHGSGHTLRISKVQL 3376
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDIEYAPKF--ISNQTIYYSWEGNPINISCDVKSNPPA 430
+D+G + C AAS G ++ L ++ P + Q G+ + + C+ + P
Sbjct: 3377 ADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP 3436
Query: 431 SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
+ W +D L + S + L++ D G Y+C A + G + + L
Sbjct: 3437 LVSWMKDG--------EPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQL 3488
Query: 491 ALADVPSSPYGVKIIELSQT 510
+ + P + ELS T
Sbjct: 3489 TVMEPPHIEDSGQPTELSLT 3508
Score = 143 bits (361), Expect = 6e-34
Identities = 117/467 (25%), Positives = 200/467 (42%), Gaps = 35/467 (7%)
Query: 42 CTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKG 100
C A G P + W+ + + S V V +G L I A + DAG YRC A++ G
Sbjct: 1907 CLASGVPPPDVSWFKGH-QPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYRCVASNVAG 1963
Query: 101 QTQ-EATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIS 159
T+ + + + ++T + P + C + +P+P + WL V+
Sbjct: 1964 STELRYGLRVNVPPRITLPPSL-PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAG 2022
Query: 160 DNRFAMLANNN-LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSF 218
+ L + + SD G Y C V A GE D +D+++ V++PP+I +
Sbjct: 2023 TPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGE-DRQDVVLQVHMPPSIL--GEEL 2078
Query: 219 NATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGP 278
N + E + C++ P P +SW+++G+ +E L L V D G
Sbjct: 2079 NVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGH 2138
Query: 279 YVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE---TTYENGQVTLVCDAEGEPIPEITWK 335
Y C A N+AG EK L V+V P + L+ T E +L C+ G P P+I+W+
Sbjct: 2139 YTCEALNQAGHSEKHYNLNVWVAP-VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWR 2197
Query: 336 RAVDGFTFTEGDKSLDGRIEVKGQHGSS---SLHIKDVKLSDSGRYDCEAASRIGGHQKS 392
+ DG L QH S+ L++ +L+ G Y CE ++ +G +
Sbjct: 2198 K--DGQPLPGEGAGL--------QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 2247
Query: 393 MYLDIEYAPKFISNQ---TIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNL 449
+ L++ P+ + T + + C+ PP ++ W RD P L
Sbjct: 2248 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG--QPVGAELGL 2305
Query: 450 KTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ + G+ + +E A + GRY+C A N G +++ L++ P
Sbjct: 2306 QLQNQGQSLHVERAQAAHT--GRYSCVAENLAGRAERKFELSVLVPP 2350
Score = 141 bits (355), Expect = 3e-33
Identities = 133/528 (25%), Positives = 213/528 (40%), Gaps = 60/528 (11%)
Query: 8 YLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQR 66
Y+LG+ V QV +++ VGE+ C A G PE + W S
Sbjct: 1112 YVLGVQVPP-----QVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSW---------SKDG 1157
Query: 67 VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR--EVVSPQ 124
VV+Q G + + DAG YRC+A+++ G V L + + + E
Sbjct: 1158 VVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAG-VDAWEVELRVLEPPHWGADETSGLL 1216
Query: 125 EFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIY 184
E GE+A + C +P P V+W A+L +L + +++ +D G Y
Sbjct: 1217 ERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDY 1276
Query: 185 RCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISW 244
C+ E R ++V VPP+I + N + G+ +T C A+G P P I W
Sbjct: 1277 ECQATNEVGSTS--RRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334
Query: 245 FRNGKLI---------------EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGE 289
++ +L+ + + L L I D G Y CRA N+AG
Sbjct: 1335 LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT 1394
Query: 290 DEKQAFLQVFVQPHII---QLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEG 346
++ L V P ++ + V L C G P P++ W + +
Sbjct: 1395 AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK--------DR 1446
Query: 347 DKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFI-- 404
L G ++ Q L I + D GRY C A S G + L + +AP I
Sbjct: 1447 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV-HAPPTIWG 1505
Query: 405 SNQTIYYS-WEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIA 463
SN+T + E + + + C+ + P +I W +D +LP T+ Y+ G + L++
Sbjct: 1506 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLP---TSTKVVYTRGGRQ-LQLG 1561
Query: 464 PTSDNDFGRYNCTATNHIG-----TRFQEYI-LALADVPSSPYGVKII 505
+D G Y C A+N +G TR Y+ + PY VK +
Sbjct: 1562 RAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV 1609
Score = 138 bits (347), Expect = 2e-32
Identities = 123/485 (25%), Positives = 210/485 (43%), Gaps = 37/485 (7%)
Query: 12 LLVSSGQALLQVTISL-SKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVV 69
LLV + +L T L +V ++ + C A+G P +I W G + R+ V
Sbjct: 2836 LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQ-NGLPFSPSPRLQV 2894
Query: 70 QKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEA-TVVLEIYQKLTFREVVSPQEFKQ 128
++G L + A + DA Y C A + G ++ T+ +++ ++ ++
Sbjct: 2895 LEDG--QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 2952
Query: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG 188
+ C V + P P V+W Y + + ++ + F + + LQ+ SD G+Y CE
Sbjct: 2953 SS-VSLPCDVHAHPNPEVTW-YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 3010
Query: 189 RVEARGEIDFRDIIVIVNVPPAISM-PQKSFNATAER-GEEMTFSCRASGSPEPAISWFR 246
+ A G D + + + V VPPA P+ +A R G++ SC PEP ++W++
Sbjct: 3011 -LNAAGR-DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 3068
Query: 247 NGK-LIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII 305
+G+ L+ L+G L ++ SD G Y C+ +N AGE + L V V P
Sbjct: 3069 DGQPLVLAQRTQALRGGQ-RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFE 3127
Query: 306 QLKNETTYE--NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS 363
K ET + + L CD G P P +TW + D+ +E HG
Sbjct: 3128 NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK----------DRM---PVESSAVHGVV 3174
Query: 364 S----LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNP 417
S L + ++ + +G Y C A + +K + + AP+ S+ ++ EG
Sbjct: 3175 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQE 3234
Query: 418 INISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTA 477
+ + C+ PP + W +D L +L+ Y G ++L+ S D G Y C A
Sbjct: 3235 VRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRAS--DAGAYTCVA 3292
Query: 478 TNHIG 482
N G
Sbjct: 3293 HNPAG 3297
Score = 131 bits (329), Expect = 3e-30
Identities = 128/490 (26%), Positives = 190/490 (38%), Gaps = 59/490 (12%)
Query: 35 GESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G +C G P I W G+ + + V L + A + G Y C
Sbjct: 2177 GHPTSLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 2235
Query: 94 QATDAKGQTQEATVVLEIY---QKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLY 150
+ ++ G + + + LE++ Q RE + Q A + C + P P V+W
Sbjct: 2236 ECSNVVGNSSQ-DLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 2294
Query: 151 HNEEVTTISDNRFAMLANNNLQILNINKSDE---GIYRC-----EGRVEARGEIDFRDII 202
+ V + N Q L++ ++ G Y C GR E + E+
Sbjct: 2295 DGQPVGA----ELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELS----- 2345
Query: 203 VIVNVPPA-ISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG 261
V VPP I N TA +T C A G P PAI WFR + + E L
Sbjct: 2346 --VLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA 2403
Query: 262 SNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYE-----NG 316
L + D G Y C A+N+AGE + ++V V P I +NE E +G
Sbjct: 2404 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI---ENEDLEEVIKVLDG 2460
Query: 317 QVT-LVCDAEGEPIPEITWKRAVDGFTFTEGDK---SLDGRIEVKGQHGSSSLHIKDVKL 372
Q L+C+ G P P++TW + DG GD S DG + L + L
Sbjct: 2461 QTAHLMCNVTGHPQPKLTWFK--DGRPLARGDAHHISPDGVL----------LQVLQANL 2508
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE-----GNPINISCDVKSN 427
S +G Y C AA+ +G K L + AP + E NPI++ C+ +
Sbjct: 2509 SSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAF 2568
Query: 428 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
P +I W +D A L + G L+I D G+Y C TN +G +
Sbjct: 2569 PSPNITWMKDGAPFEASRNIQLLPGTHG----LQILNAQKEDAGQYTCVVTNELGEAVKN 2624
Query: 488 YILALADVPS 497
Y + + PS
Sbjct: 2625 YHVEVLIPPS 2634
Score = 130 bits (326), Expect = 7e-30
Identities = 120/489 (24%), Positives = 212/489 (43%), Gaps = 43/489 (8%)
Query: 30 VELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V+ G C A G P ++ W++ +G + + ++ +G S L + + +
Sbjct: 1606 VKAVAGRPVALECVARGHPSPTLSWHH-EGLPVAESNESRLETDG--SVLRLESPGEASS 1662
Query: 89 GIYRCQATDAKGQTQ-EATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
G+Y C A+ G+ + +V +++ +L E + G+ E+ C+ S SP P +
Sbjct: 1663 GLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 1722
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN- 206
WL + ++ + A L I ++ G++ C+ EA ++ V V+
Sbjct: 1723 WLQNGRPAEELAGVQVAS-QGTTLHIDHVELDHSGLFACQATNEAGTA--GAEVEVSVHG 1779
Query: 207 --VPPAISMPQKSFNATAERGEEMTFSC-----RASGS-PEPAI--SWFRNGKLIEENEK 256
P + +P ++ E +C R G+ P+P + W G L E
Sbjct: 1780 EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG 1839
Query: 257 YILKGS-NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ-LKNETTYE 314
+ S L + + D G Y C ATN AGE +++ L+V V P+I N+ E
Sbjct: 1840 IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLE 1899
Query: 315 NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEG-DKSLDGRIEVKGQHGSSSLHIKDVKLS 373
N VTL C A G P P+++W + + G S+DGR+ L I+ +LS
Sbjct: 1900 NASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------LRIEQAQLS 1949
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEG-----NPINISCDVKSNP 428
D+G Y C A++ G + L + P+ T+ S G P+ ++C+ P
Sbjct: 1950 DAGSYRCVASNVAGSTELRYGLRVNVPPRI----TLPPSLPGPVLVNTPVRLTCNATGAP 2005
Query: 429 PASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
++ W +D + T L+ + GR +L +A +D GRY+C A + +G Q+
Sbjct: 2006 SPTLMWLKDGNPVSPAGTPGLQVFPGGR--VLTLASARASDSGRYSCVAVSAVGEDRQDV 2063
Query: 489 ILALADVPS 497
+L + PS
Sbjct: 2064 VLQVHMPPS 2072
Score = 129 bits (323), Expect = 1e-29
Identities = 116/457 (25%), Positives = 185/457 (40%), Gaps = 38/457 (8%)
Query: 35 GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G TC G P ++ W + S VV + G RL + AG Y C
Sbjct: 3139 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG---RLQLSRLQPAQAGTYTC 3195
Query: 94 QATDAKGQTQEATVV-LEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHN 152
A + + + ++ VV + + ++ V +G++ + C P P V+WL
Sbjct: 3196 VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDG 3255
Query: 153 EEV-TTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAI 211
+ + + L +L + + SD G Y C A GE D R V V VPP I
Sbjct: 3256 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA-GE-DARLHTVNVLVPPTI 3313
Query: 212 SMPQKSFNATAER-GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRN 270
R GE +T C GSP +SW ++G + +++ +L GS L +
Sbjct: 3314 KQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISK 3373
Query: 271 IINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI--IQLKNETTYENGQ-VTLVCDAEGE 327
+ +D G + C A + AG ++ LQV V P + ++ +N+ G V L C+A G
Sbjct: 3374 VQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV 3433
Query: 328 PIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG 387
P+P ++W + +G+ L +E SL ++ V DSG Y C A S G
Sbjct: 3434 PLPLVSWMK--------DGEPLLSQSLE-----QGPSLQLEAVGAGDSGTYSCVAVSEAG 3480
Query: 388 GHQKSMYLDIEYAPKF--ISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN 445
++ L + P T G P+ + CD + P +I W +D L
Sbjct: 3481 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL---- 3536
Query: 446 TTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
T L+ S +++ D G Y C A + G
Sbjct: 3537 -TRLENNSRATRVL------RVRDAGLYTCLAESPAG 3566
Score = 127 bits (320), Expect = 3e-29
Identities = 113/476 (23%), Positives = 191/476 (40%), Gaps = 28/476 (5%)
Query: 28 SKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIED 87
S V E C A G P + +G + + V G +L I +A+ ED
Sbjct: 3955 SVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG---QLRIAHASPED 4011
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
AG Y C A ++ G T ++ + + +G A + C+ SP P ++
Sbjct: 4012 AGNYLCIAKNSAGSAMGKTRLV-VQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT 4070
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNV 207
W + V+ ++ +F + + L + N+ D G Y C A G R + I+ +
Sbjct: 4071 WDKDGQPVSG-AEGKFTIQPSGELLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVL 4128
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT 267
P ++P + + G+ + C A GSP P I W N + + E GS +
Sbjct: 4129 PVFTTLPG---DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRA 4185
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYE--NGQVTLVCDAE 325
+ D G YVC A N+ G + +F+ V P + E G + L C
Sbjct: 4186 A--VSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 4243
Query: 326 GEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASR 385
G+P+P+I W + +G + + Q+GS ++H + D+GRY C A +
Sbjct: 4244 GDPVPDIHWIK--------DGLPLRGSHLRHQLQNGSLTIH--RTERDDAGRYQCLAENE 4293
Query: 386 IGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN 445
+G +K + L ++ AP F G+ + + C P +I W + P +
Sbjct: 4294 MGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL--QAGQPLRA 4351
Query: 446 TTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG 501
+ L+T G L + D G Y+C A N +G+ L + P +G
Sbjct: 4352 SRRLRTLPDGS---LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWG 4404
Score = 125 bits (313), Expect = 2e-28
Identities = 102/404 (25%), Positives = 164/404 (40%), Gaps = 22/404 (5%)
Query: 87 DAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK-QGEDAEVVCRVSSSPAPA 145
D+G+Y C+A + G Q +L + + + G D E+ C S P P
Sbjct: 1380 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ 1439
Query: 146 VSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIV 205
V W + V + L+I + DEG Y+C A + RD + V
Sbjct: 1440 VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA--RDFQLRV 1497
Query: 206 NVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTE 265
+ PP I ++ + C A G P P I+WF++G L+ + K + +
Sbjct: 1498 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ 1557
Query: 266 LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE----TTYENGQVTLV 321
L + +SD G Y C+A+N G EK L V+V P I V L
Sbjct: 1558 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALE 1617
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 381
C A G P P ++W +G E ++S R+E G S L ++ + SG Y C
Sbjct: 1618 CVARGHPSPTLSWHH--EGLPVAESNES---RLETDG----SVLRLESPGEASSGLYSCV 1668
Query: 382 AASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCDVKSNPPASIHWRRDKL 439
A+S G ++++ P+ + + + + G P+ + C +P +I W ++
Sbjct: 1669 ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG- 1727
Query: 440 VLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
PA+ ++ S G L I + G + C ATN GT
Sbjct: 1728 -RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGT 1768
Score = 125 bits (313), Expect = 2e-28
Identities = 126/520 (24%), Positives = 211/520 (40%), Gaps = 72/520 (13%)
Query: 35 GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G++ C G P+ + W+ G + + +GV L + AN+ AG Y C
Sbjct: 2460 GQTAHLMCNVTGHPQPKLTWFK-DGRPLARGDAHHISPDGVL--LQVLQANLSSAGHYSC 2516
Query: 94 QATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEV--------VCRVSSSPAPA 145
A +A G E T ++ L ++ E E+ V +C + P+P
Sbjct: 2517 IAANAVG---EKTKHFQL-SVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN 2572
Query: 146 VSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIV 205
++W+ S N + + LQILN K D G Y C E + ++ V V
Sbjct: 2573 ITWMKDGAPFEA-SRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAV--KNYHVEV 2629
Query: 206 NVPPAISMPQKSFNATAER-----GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK 260
+PP+IS + +T C + P P I W+++G+ + + + +
Sbjct: 2630 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVL 2689
Query: 261 GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP------------HIIQLK 308
G L ++ SD G Y+C ATN AGED++ + + V P I+ +
Sbjct: 2690 GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 2749
Query: 309 NE-----TTY----ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQ 359
E T Y EN L CD P P++TW R D+ L EV
Sbjct: 2750 EEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE---------DQPLSAGDEVSVL 2800
Query: 360 HGSSSLHIKDVKLSDSGRYDCEAASRIGG---HQKSMYLD----IEYAPKFISNQTIYYS 412
G L I V+ ++GRY C+A++ +G H + + L + + + T+ S
Sbjct: 2801 QGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 2860
Query: 413 WEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGR 472
+ +++ C NP +I W ++ LP + L+ G+ +L+++ D
Sbjct: 2861 ---STVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQ--VLQVSTAEVADAAS 2913
Query: 473 YNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTA 512
Y C A N G+ + + L + VP G ++L Q TA
Sbjct: 2914 YMCVAENQAGSAEKLFTLRV-QVPPRIAG---LDLEQVTA 2949
Score = 119 bits (298), Expect = 1e-26
Identities = 88/340 (25%), Positives = 146/340 (42%), Gaps = 26/340 (7%)
Query: 160 DNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFN 219
+ F N++ +IL +K++EG Y C V G + IV+ + PP + +P N
Sbjct: 470 ERHFQESGNSSWEILRASKAEEGTYECTA-VSRAGTGRAKAQIVVTDPPPQL-VPAP--N 525
Query: 220 ATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPY 279
T GE SCR G ++W R+ +++ + + + ++ L + II +DGG Y
Sbjct: 526 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 585
Query: 280 VCRATNKAGEDEKQAFLQVFVQPHI-IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAV 338
C A+N G +L V P + I ++ + +V + C A G P P I+W R
Sbjct: 586 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 645
Query: 339 DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
D RI V Q +L I+ V D+G Y C+A + +G Q+++ L
Sbjct: 646 QAL-------QEDSRIHVDAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 695
Query: 399 YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD--KLVLPAKNTTNLKTYSTGR 456
P + + G + C+ PP + W R +++L + +++ K
Sbjct: 696 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK------ 749
Query: 457 KMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
L I + D G Y C A N +G E LA+ P
Sbjct: 750 ---LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 786
Score = 119 bits (297), Expect = 2e-26
Identities = 127/498 (25%), Positives = 192/498 (38%), Gaps = 41/498 (8%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLT 79
L V L +V VG+ C A G P +I W G V V +G + L
Sbjct: 1690 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQ-NGRPAEELAGVQVASQG--TTLH 1746
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSP-QEFKQGEDAEVVCRV 138
I + ++ +G++ CQAT+ G T A V + ++ + + P ++ G +
Sbjct: 1747 IDHVELDHSGLFACQATNEAG-TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPA 1805
Query: 139 SSSPAPAVSWLYHNE---------------EVTTISDNRFAMLANNNLQILNINKSDEGI 183
+ P W H + E T I A LQI ++ DEGI
Sbjct: 1806 ACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP---VAYSLPPPLQIEKVDLRDEGI 1862
Query: 184 YRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS 243
Y C GE R++ + V VPP I N +T C ASG P P +S
Sbjct: 1863 YTCAA-TNLAGESK-REVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVS 1918
Query: 244 WFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPH 303
WF+ + + + L + SD G Y C A+N AG E + L+V V P
Sbjct: 1919 WFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPR 1978
Query: 304 IIQLKN--ETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHG 361
I + N V L C+A G P P + W + DG S G ++ G
Sbjct: 1979 ITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK--DG-----NPVSPAGTPGLQVFPG 2031
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
L + + SDSGRY C A S +G ++ + L + P + + + +
Sbjct: 2032 GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALE 2091
Query: 422 CDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHI 481
C + PP + W +D L + +L + K +L++ D G Y C A N
Sbjct: 2092 CQSHAMPPPVLSWWKDGRPLEPRPGVHL----SADKALLQVDRADVWDAGHYTCEALNQA 2147
Query: 482 GTRFQEYILALADVPSSP 499
G + Y L + P P
Sbjct: 2148 GHSEKHYNLNVWVAPVFP 2165
Score = 116 bits (291), Expect = 8e-26
Identities = 129/557 (23%), Positives = 207/557 (37%), Gaps = 97/557 (17%)
Query: 13 LVSSGQALLQVTISLSKVELSVGESKFFTCTAI-GEPESIDWYNPQGEKIISTQRVVVQK 71
L+ +G A Q+ S V + G+ C + G P + G + R ++
Sbjct: 877 LIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA 936
Query: 72 EGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGED 131
+G L + A E AG Y C AT+ G +Q V L + + +G
Sbjct: 937 DG---SLHLDRALQEHAGRYSCVATNTAG-SQHRDVELVVQVPPRIHPTATHHITNEGVP 992
Query: 132 AEVVCRVSSSPAPAVSWLYHNEEVTT---------------------------------- 157
A + C S PAP ++W +T+
Sbjct: 993 ASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052
Query: 158 --------ISDNRFAM----------LANNNLQILNINKSDEGIYRCEGRVEARGEIDFR 199
+S NR A+ L + +L++ + D G Y C A G R
Sbjct: 1053 GFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPA-GSASHR 1111
Query: 200 DIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYIL 259
++ V VPP + + GE + +C A G+PEP +SW ++G +++
Sbjct: 1112 -YVLGVQVPPQVQPGPRVLKVLV--GEALDLNCVAEGNPEPQLSWSKDGVVLQG------ 1162
Query: 260 KGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPH-----IIQLKNETTYE 314
+G + I SD G Y C A+N AG D + L+V PH L E
Sbjct: 1163 RGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGE 1222
Query: 315 NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSD 374
N +L C A G P P++TW++ + L G+ V SL + V +D
Sbjct: 1223 N--ASLPCPARGTPKPQVTWRKG-------PSSEPLHGQPGVAVLE-EGSLFLASVSPAD 1272
Query: 375 SGRYDCEAASRIGGHQKSMYLDIEYAPKFI---SNQTIYYSWEGNPINISCDVKSNPPAS 431
SG Y+C+A + +G + L + Y P I + G + + CD P
Sbjct: 1273 SGDYECQATNEVGSTSRRAKL-VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE 1331
Query: 432 IHWRRDKLVLP-----AKNTTNLKTYSTGRKMILEIAPT------SDNDFGRYNCTATNH 480
I W +D ++ A +L G +L+ + + D G Y+C A N
Sbjct: 1332 IVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQ 1391
Query: 481 IGTRFQEYILALADVPS 497
GT +++ L + PS
Sbjct: 1392 AGTAQRDFHLLVLTPPS 1408
Score = 110 bits (276), Expect = 4e-24
Identities = 115/513 (22%), Positives = 201/513 (39%), Gaps = 54/513 (10%)
Query: 28 SKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIED 87
+++ L+ G C A G P+ ++ G+ + + SR T + D
Sbjct: 3503 TELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLEN--------NSRATRV-LRVRD 3553
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQ--EFKQG---EDAEVVCRVSSSP 142
AG+Y C A G +++ V + +V P+ F G + C V + P
Sbjct: 3554 AGLYTCLAESPAGAIEKSFRV----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP 3609
Query: 143 APAVSWLYHNEEVTTISDNRFAMLANNN-LQILNINKSDEGIYRCEGRVEARG-----EI 196
AP ++W H + + D LQ+ ++ +D G Y C R A +
Sbjct: 3610 APKITW--HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 3667
Query: 197 DFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK 256
+ + I + PPA+++ S N TA C+A G P P +SW ++ ++
Sbjct: 3668 EIHTVPTIRSGPPAVNV---SVNQTA------LLPCQADGVPAPLVSWRKDRVPLDPRSP 3718
Query: 257 YILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQL-KNETTYEN 315
L ++ ++ D G Y+C A+N AG D + L+V P I N T +
Sbjct: 3719 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778
Query: 316 GQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH--GSSSLHIKDVKLS 373
L C+A G P P + W + +G K LD R++ S++L +
Sbjct: 3779 TPALLPCEASGSPKPLVVW--------WKDGQK-LDFRLQQGAYRLLPSNALLLTAPGPQ 3829
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIH 433
DS +++C ++ +G + + + P +QT + P+ ++C P ++
Sbjct: 3830 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 3889
Query: 434 WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALA 493
W + L A+ + Y LEI GRY C+A N G + L
Sbjct: 3890 WSKAGAQLGARGS----GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLT-- 3943
Query: 494 DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526
V +SP + + + A+ P G+P
Sbjct: 3944 -VQASPVVKPLPSVVRAVAEEEVLLPCEASGIP 3975
Score = 99.0 bits (245), Expect = 2e-20
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 31/450 (6%)
Query: 42 CTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQ 101
C A G P + + GE ++S ++G +L A D+G Y C A G+
Sbjct: 3428 CEARGVPLPLVSWMKDGEPLLSQSL----EQGPSLQLEAVGAG--DSGTYSCVAVSEAGE 3481
Query: 102 TQEATVVLEIYQKLTFREVVSPQEFK--QGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIS 159
+ L + + + P E G E++C +P P ++W + +T +
Sbjct: 3482 ARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLE 3540
Query: 160 DNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFN 219
+N A ++L + D G+Y C A G I+ + V V PP I P+
Sbjct: 3541 NNSRAT------RVLRVR--DAGLYTCLAESPA-GAIE-KSFRVRVQAPPNIVGPRGPRF 3590
Query: 220 ATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPY 279
++ C P P I+W R+G +++E+ L ++ + +D G Y
Sbjct: 3591 VVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDY 3650
Query: 280 VCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLV-CDAEGEPIPEITWKRAV 338
C A N AG +++ P I Q L+ C A+G P P ++W++
Sbjct: 3651 SCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK-- 3708
Query: 339 DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
LD R SL I+ V D+G Y C A++ G ++ L +
Sbjct: 3709 -------DRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 3761
Query: 399 YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKM 458
P + + P + C+ +P + W +D L + +
Sbjct: 3762 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 3821
Query: 459 ILEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
+L AP D ++ C +N +G + Y
Sbjct: 3822 LL-TAP-GPQDSAQFECVVSNEVGEAHRLY 3849
Score = 82.8 bits (203), Expect = 1e-15
Identities = 64/253 (25%), Positives = 106/253 (41%), Gaps = 15/253 (5%)
Query: 246 RNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVF-VQPHI 304
R G+ E++ + N+ + ++ G Y C A ++AG +A + V P +
Sbjct: 461 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 520
Query: 305 IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSS 364
+ N T L C GE +TW R + GR+ Q S
Sbjct: 521 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL------PASTGRV---AQLADLS 571
Query: 365 LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDV 424
L I + +D GRY C A++ G + S++L + AP+ + + + +G + +SC
Sbjct: 572 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA 631
Query: 425 KSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
P I W R+ L + + + + G +I +AP D G Y+C ATN +GT
Sbjct: 632 SGYPTPHISWSRESQAL--QEDSRIHVDAQGTLIIQGVAP---EDAGNYSCQATNEVGTD 686
Query: 485 FQEYILALADVPS 497
+ L D PS
Sbjct: 687 QETVTLYYTDPPS 699
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 148 bits (374), Expect = 2e-35
Identities = 163/691 (23%), Positives = 279/691 (40%), Gaps = 67/691 (9%)
Query: 26 SLSKVELSVGESKFFTCTA--IGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNA 83
++ VE+ GES C EP I W N + I +RV + + G +Y A
Sbjct: 137 TVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNG-----NLYFA 191
Query: 84 NI---EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK------------Q 128
N+ ++ Y C A +T +++ K T + Q
Sbjct: 192 NVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ 251
Query: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG 188
G+ + C P P + WL + + +D N LQ+L + + D+G YRC
Sbjct: 252 GQPLVLECIAEGFPTPTIKWLRPSGPMP--ADRVTYQNHNKTLQLLKVGEEDDGEYRCLA 309
Query: 189 RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNG 248
+ G + + P + PQ GE C+ G P+P ++W NG
Sbjct: 310 E-NSLGSARHAYYVTVEAAPYWLHKPQSHLYGP---GETARLDCQVQGRPQPEVTWRING 365
Query: 249 KLIEE---NEKY-ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI 304
+EE ++KY I +G+ L + N+ SD C A N+ G A++ V P
Sbjct: 366 IPVEELAKDQKYRIQRGA---LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 422
Query: 305 IQLKNETTY---ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHG 361
I + TY + L+C A G P+P + W DG T + ++ +
Sbjct: 423 ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDE-DGTTVLQDERFFP--------YA 473
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
+ +L I+D++ +D+GRY C AA+ L ++ A + +G+ + +
Sbjct: 474 NGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFT 533
Query: 422 CDVKSNPPA--SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
C +P SI WR D L ++ GR +I + +D G Y+C A+
Sbjct: 534 CQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSL---DYSDQGNYSCVAST 590
Query: 480 HIGTRFQEYILALADVPSSPYGVKIIEL---SQTTAKVSFNKPDSHGGVPIHHYQVDV-- 534
+ L + P + + +L +Q+ +VS++ + H PI Y ++
Sbjct: 591 ELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNA-PIEKYDIEFED 649
Query: 535 KEVASEIW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE 593
KE+A E W + + G QT L L P Y RV A+N G G+ S + P
Sbjct: 650 KEMAPEKWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAA 708
Query: 594 PSPPSIHGQPSSGKSFKLSIT----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD 649
P + + ++ + IT + D AP ++Y V++R + W E+ V +
Sbjct: 709 PEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIV--SDP 766
Query: 650 HIILEHLQWTMGYEVQITAANRLGYS-EPTV 679
+++ + + YE+++ A N G EP V
Sbjct: 767 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQV 797
Score = 116 bits (291), Expect = 8e-26
Identities = 165/685 (24%), Positives = 261/685 (38%), Gaps = 88/685 (12%)
Query: 42 CTAIGEPESIDWYNPQGEKIISTQR--VVVQKEGVRSRLTIYNANIEDA----GIYRCQA 95
C A G+PE + G + V V + TI N A GIYRC A
Sbjct: 52 CEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFA 111
Query: 96 TDAKG--QTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNE 153
++ G + E ++ E K +E V P E ++GE + C S P + +++
Sbjct: 112 SNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSK 170
Query: 154 EVTTISDNRFAMLANNNLQILNINKSD-EGIYRCEGRVEARGEIDFRDII---------V 203
+ D R M N NL N+ SD Y C I ++ I +
Sbjct: 171 ILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSM 230
Query: 204 IVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFR-NGKLIEENEKYILKGS 262
I P + S + A +G+ + C A G P P I W R +G + + Y +
Sbjct: 231 IDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTY--QNH 288
Query: 263 NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVT-LV 321
N L + + D G Y C A N G ++ V P+ + Y G+ L
Sbjct: 289 NKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLD 348
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 381
C +G P PE+TW+ ++G E K RI+ +L + +V+ SD+ CE
Sbjct: 349 CQVQGRPQPEVTWR--INGIPVEELAKDQKYRIQ------RGALILSNVQPSDTMVTQCE 400
Query: 382 AASRIGGHQKSMYLDIEYAPKFI---SNQTIYYSWEGNPINISCDVKSNPPASIHWRRDK 438
A +R G + Y+ + P I NQT Y + +G+ + C P S+ W
Sbjct: 401 ARNRHGLLLANAYIYVVQLPAKILTADNQT-YMAVQGSTAYLLCKAFGAPVPSVQW---- 455
Query: 439 LVLPAKNTTNLK-----TYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALA 493
L TT L+ Y+ G L I ND GRY C A N L +
Sbjct: 456 --LDEDGTTVLQDERFFPYANG---TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVK 510
Query: 494 DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
D G + + + ++V+F S D S W R G
Sbjct: 511 DATQITQGPR-STIEKKGSRVTFTCQAS----------FDPSLQPSITW---RGDGRD-- 554
Query: 554 VVLNNLEPNTTYEIR-----VAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPS---- 604
L L + Y I + +++ QG+YS + + V + + G P
Sbjct: 555 --LQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPR 612
Query: 605 ---------SGKSFKLSITKQDDGGAPILEYIVKYRSKD-KEDQWLE-KKVQGNKDHIIL 653
+ ++S + +D API +Y +++ K+ ++W KV GN+ L
Sbjct: 613 LVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL 672
Query: 654 EHLQWTMGYEVQITAANRLGYSEPT 678
+ L + Y ++TA N+ G EP+
Sbjct: 673 K-LSPYVHYTFRVTAINKYGPGEPS 696
Score = 107 bits (266), Expect = 6e-23
Identities = 167/703 (23%), Positives = 268/703 (38%), Gaps = 67/703 (9%)
Query: 20 LLQVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRL 78
LL T S S + G+ C A G P +I W P G + RV Q L
Sbjct: 237 LLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGP--MPADRVTYQNHN--KTL 292
Query: 79 TIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRV 138
+ ED G YRC A ++ G + A V + S + GE A + C+V
Sbjct: 293 QLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQS-HLYGPGETARLDCQV 351
Query: 139 SSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDF 198
P P V+W + V ++ ++ + L + N+ SD + +CE R G +
Sbjct: 352 QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEAR-NRHGLLLA 410
Query: 199 RDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWF-RNGKLIEENEKY 257
I +V +P I + + A +G C+A G+P P++ W +G + ++E++
Sbjct: 411 NAYIYVVQLPAKI-LTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 469
Query: 258 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENG- 316
+ T L +R++ +D G Y C A N A L+V I Q T + G
Sbjct: 470 FPYANGT-LGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGS 528
Query: 317 QVTLVCDAEGEPI--PEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSD 374
+VT C A +P P ITW+ DG E S IE L I + SD
Sbjct: 529 RVTFTCQASFDPSLQPSITWRG--DGRDLQELGDSDKYFIE------DGRLVIHSLDYSD 580
Query: 375 SGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCDVKSNPPASI 432
G Y C A++ + + L + +P + + + + + +S + A I
Sbjct: 581 QGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI 640
Query: 433 HWR----RDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG----TR 484
DK + P K + K L+++P F TA N G +
Sbjct: 641 EKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSP 697
Query: 485 FQEYILALADVP-SSPYGVKIIELSQTTAKVSFNKP--DSHGGVPIHHYQVDVKEVASEI 541
E ++ P +P VK E ++TT V KP P Y+V
Sbjct: 698 VSETVVTPEAAPEKNPVDVK-GEGNETTNMVITWKPLRWMDWNAPQVQYRVQ-------- 748
Query: 542 WKIVRSHG-------VQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI---FQTLPV 591
W+ + G +V++N YEI+V AVN +G+G ++ I + P
Sbjct: 749 WRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQ 808
Query: 592 REPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDH- 650
P I SS K + Y V Y + + + ++ + +KDH
Sbjct: 809 AIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI--HKDHV 866
Query: 651 --------IILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMP 685
+IL L+ Y +++ A N G + + FS P
Sbjct: 867 VVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTP 909
Score = 76.6 bits (187), Expect = 9e-14
Identities = 80/402 (19%), Positives = 147/402 (36%), Gaps = 60/402 (14%)
Query: 130 EDAEVVCRVSSSPAPAVSWL-----YHNEEVTTIS------DNRFAMLANNNLQILNINK 178
+D + C S P W + +E ++ F + NN+ N +
Sbjct: 46 DDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNS----NFAQ 101
Query: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNAT-AERGEEMTFSCRASGS 237
+GIYRC + + ++ P P+++ E GE + C S
Sbjct: 102 RFQGIYRCFASNKLGTAMSHEIRLMAEGAP---KWPKETVKPVEVEEGESVVLPCNPPPS 158
Query: 238 PEPAISWFRNGKLIE-ENEKYILKGSNTELTVRNIINSDG-GPYVC-------------- 281
EP ++ N K++ + ++ + G N L N++ SD Y+C
Sbjct: 159 AEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKE 218
Query: 282 ------RATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWK 335
+ATN + + + H++ L+ + + L C AEG P P I W
Sbjct: 219 PIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQP------LVLECIAEGFPTPTIKWL 272
Query: 336 RAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYL 395
R G D V Q+ + +L + V D G Y C A + +G + + Y+
Sbjct: 273 RP-------SGPMPAD---RVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYV 322
Query: 396 DIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTG 455
+E AP ++ + G + C V+ P + WR + +P + + Y
Sbjct: 323 TVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING--IPVEELAKDQKYRIQ 380
Query: 456 RKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPS 497
R ++ ++ +D C A N G + + +P+
Sbjct: 381 RGALI-LSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPA 421
Score = 35.8 bits (81), Expect = 0.17
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 1/84 (1%)
Query: 552 TMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKL 611
T V+L+ L P ++Y + V A NG+G G S+ F T P ++H + S S L
Sbjct: 873 TSVILSGLRPYSSYHLEVQAFNGRGSGPASEF-TFSTPEGVPGHPEALHLECQSNTSLLL 931
Query: 612 SITKQDDGGAPILEYIVKYRSKDK 635
+ Y++ Y D+
Sbjct: 932 RWQPPLSHNGVLTGYVLSYHPLDE 955
Score = 31.6 bits (70), Expect = 3.2
Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 14/178 (7%)
Query: 313 YENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKL 372
+ ++L C+A G+P + W R DG F + + L + GS ++ +
Sbjct: 43 FPTDDISLKCEASGKPEVQFRWTR--DGVHF-KPKEELGVTVYQSPHSGSFTITGNNSNF 99
Query: 373 SD--SGRYDCEAASRIG-GHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCD-VKS 426
+ G Y C A++++G + L E APK+ +T+ EG + + C+ S
Sbjct: 100 AQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW-PKETVKPVEVEEGESVVLPCNPPPS 158
Query: 427 NPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
P I+W K +L K + G + TSDN Y C A + GTR
Sbjct: 159 AEPLRIYWMNSK-ILHIKQDERVTMGQNGNLYFANVL-TSDN-HSDYICHA-HFPGTR 212
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 148 bits (374), Expect = 2e-35
Identities = 163/691 (23%), Positives = 279/691 (40%), Gaps = 67/691 (9%)
Query: 26 SLSKVELSVGESKFFTCTA--IGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNA 83
++ VE+ GES C EP I W N + I +RV + + G +Y A
Sbjct: 142 TVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNG-----NLYFA 196
Query: 84 NI---EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK------------Q 128
N+ ++ Y C A +T +++ K T + Q
Sbjct: 197 NVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ 256
Query: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG 188
G+ + C P P + WL + + +D N LQ+L + + D+G YRC
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSGPMP--ADRVTYQNHNKTLQLLKVGEEDDGEYRCLA 314
Query: 189 RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNG 248
+ G + + P + PQ GE C+ G P+P ++W NG
Sbjct: 315 E-NSLGSARHAYYVTVEAAPYWLHKPQSHLYGP---GETARLDCQVQGRPQPEVTWRING 370
Query: 249 KLIEE---NEKY-ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI 304
+EE ++KY I +G+ L + N+ SD C A N+ G A++ V P
Sbjct: 371 IPVEELAKDQKYRIQRGA---LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 427
Query: 305 IQLKNETTY---ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHG 361
I + TY + L+C A G P+P + W DG T + ++ +
Sbjct: 428 ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDE-DGTTVLQDERFFP--------YA 478
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
+ +L I+D++ +D+GRY C AA+ L ++ A + +G+ + +
Sbjct: 479 NGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFT 538
Query: 422 CDVKSNPPA--SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
C +P SI WR D L ++ GR +I + +D G Y+C A+
Sbjct: 539 CQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSL---DYSDQGNYSCVAST 595
Query: 480 HIGTRFQEYILALADVPSSPYGVKIIEL---SQTTAKVSFNKPDSHGGVPIHHYQVDV-- 534
+ L + P + + +L +Q+ +VS++ + H PI Y ++
Sbjct: 596 ELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNA-PIEKYDIEFED 654
Query: 535 KEVASEIW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE 593
KE+A E W + + G QT L L P Y RV A+N G G+ S + P
Sbjct: 655 KEMAPEKWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAA 713
Query: 594 PSPPSIHGQPSSGKSFKLSIT----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD 649
P + + ++ + IT + D AP ++Y V++R + W E+ V +
Sbjct: 714 PEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIV--SDP 771
Query: 650 HIILEHLQWTMGYEVQITAANRLGYS-EPTV 679
+++ + + YE+++ A N G EP V
Sbjct: 772 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQV 802
Score = 116 bits (291), Expect = 8e-26
Identities = 165/685 (24%), Positives = 261/685 (38%), Gaps = 88/685 (12%)
Query: 42 CTAIGEPESIDWYNPQGEKIISTQR--VVVQKEGVRSRLTIYNANIEDA----GIYRCQA 95
C A G+PE + G + V V + TI N A GIYRC A
Sbjct: 57 CEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFA 116
Query: 96 TDAKG--QTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNE 153
++ G + E ++ E K +E V P E ++GE + C S P + +++
Sbjct: 117 SNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSK 175
Query: 154 EVTTISDNRFAMLANNNLQILNINKSD-EGIYRCEGRVEARGEIDFRDII---------V 203
+ D R M N NL N+ SD Y C I ++ I +
Sbjct: 176 ILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSM 235
Query: 204 IVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFR-NGKLIEENEKYILKGS 262
I P + S + A +G+ + C A G P P I W R +G + + Y +
Sbjct: 236 IDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTY--QNH 293
Query: 263 NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVT-LV 321
N L + + D G Y C A N G ++ V P+ + Y G+ L
Sbjct: 294 NKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLD 353
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 381
C +G P PE+TW+ ++G E K RI+ +L + +V+ SD+ CE
Sbjct: 354 CQVQGRPQPEVTWR--INGIPVEELAKDQKYRIQ------RGALILSNVQPSDTMVTQCE 405
Query: 382 AASRIGGHQKSMYLDIEYAPKFI---SNQTIYYSWEGNPINISCDVKSNPPASIHWRRDK 438
A +R G + Y+ + P I NQT Y + +G+ + C P S+ W
Sbjct: 406 ARNRHGLLLANAYIYVVQLPAKILTADNQT-YMAVQGSTAYLLCKAFGAPVPSVQW---- 460
Query: 439 LVLPAKNTTNLK-----TYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALA 493
L TT L+ Y+ G L I ND GRY C A N L +
Sbjct: 461 --LDEDGTTVLQDERFFPYANG---TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVK 515
Query: 494 DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
D G + + + ++V+F S D S W R G
Sbjct: 516 DATQITQGPR-STIEKKGSRVTFTCQAS----------FDPSLQPSITW---RGDGRD-- 559
Query: 554 VVLNNLEPNTTYEIR-----VAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPS---- 604
L L + Y I + +++ QG+YS + + V + + G P
Sbjct: 560 --LQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPR 617
Query: 605 ---------SGKSFKLSITKQDDGGAPILEYIVKYRSKD-KEDQWLE-KKVQGNKDHIIL 653
+ ++S + +D API +Y +++ K+ ++W KV GN+ L
Sbjct: 618 LVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL 677
Query: 654 EHLQWTMGYEVQITAANRLGYSEPT 678
+ L + Y ++TA N+ G EP+
Sbjct: 678 K-LSPYVHYTFRVTAINKYGPGEPS 701
Score = 107 bits (266), Expect = 6e-23
Identities = 167/703 (23%), Positives = 268/703 (38%), Gaps = 67/703 (9%)
Query: 20 LLQVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRL 78
LL T S S + G+ C A G P +I W P G + RV Q L
Sbjct: 242 LLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGP--MPADRVTYQNHN--KTL 297
Query: 79 TIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRV 138
+ ED G YRC A ++ G + A V + S + GE A + C+V
Sbjct: 298 QLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQS-HLYGPGETARLDCQV 356
Query: 139 SSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDF 198
P P V+W + V ++ ++ + L + N+ SD + +CE R G +
Sbjct: 357 QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEAR-NRHGLLLA 415
Query: 199 RDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWF-RNGKLIEENEKY 257
I +V +P I + + A +G C+A G+P P++ W +G + ++E++
Sbjct: 416 NAYIYVVQLPAKI-LTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 474
Query: 258 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENG- 316
+ T L +R++ +D G Y C A N A L+V I Q T + G
Sbjct: 475 FPYANGT-LGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGS 533
Query: 317 QVTLVCDAEGEPI--PEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSD 374
+VT C A +P P ITW+ DG E S IE L I + SD
Sbjct: 534 RVTFTCQASFDPSLQPSITWRG--DGRDLQELGDSDKYFIE------DGRLVIHSLDYSD 585
Query: 375 SGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCDVKSNPPASI 432
G Y C A++ + + L + +P + + + + + +S + A I
Sbjct: 586 QGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI 645
Query: 433 HWR----RDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG----TR 484
DK + P K + K L+++P F TA N G +
Sbjct: 646 EKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSP 702
Query: 485 FQEYILALADVP-SSPYGVKIIELSQTTAKVSFNKP--DSHGGVPIHHYQVDVKEVASEI 541
E ++ P +P VK E ++TT V KP P Y+V
Sbjct: 703 VSETVVTPEAAPEKNPVDVK-GEGNETTNMVITWKPLRWMDWNAPQVQYRVQ-------- 753
Query: 542 WKIVRSHG-------VQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI---FQTLPV 591
W+ + G +V++N YEI+V AVN +G+G ++ I + P
Sbjct: 754 WRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQ 813
Query: 592 REPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDH- 650
P I SS K + Y V Y + + + ++ + +KDH
Sbjct: 814 AIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI--HKDHV 871
Query: 651 --------IILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMP 685
+IL L+ Y +++ A N G + + FS P
Sbjct: 872 VVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTP 914
Score = 76.6 bits (187), Expect = 9e-14
Identities = 80/402 (19%), Positives = 147/402 (36%), Gaps = 60/402 (14%)
Query: 130 EDAEVVCRVSSSPAPAVSWL-----YHNEEVTTIS------DNRFAMLANNNLQILNINK 178
+D + C S P W + +E ++ F + NN+ N +
Sbjct: 51 DDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNS----NFAQ 106
Query: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNAT-AERGEEMTFSCRASGS 237
+GIYRC + + ++ P P+++ E GE + C S
Sbjct: 107 RFQGIYRCFASNKLGTAMSHEIRLMAEGAP---KWPKETVKPVEVEEGESVVLPCNPPPS 163
Query: 238 PEPAISWFRNGKLIE-ENEKYILKGSNTELTVRNIINSDG-GPYVC-------------- 281
EP ++ N K++ + ++ + G N L N++ SD Y+C
Sbjct: 164 AEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKE 223
Query: 282 ------RATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWK 335
+ATN + + + H++ L+ + + L C AEG P P I W
Sbjct: 224 PIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQP------LVLECIAEGFPTPTIKWL 277
Query: 336 RAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYL 395
R G D V Q+ + +L + V D G Y C A + +G + + Y+
Sbjct: 278 RP-------SGPMPAD---RVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYV 327
Query: 396 DIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTG 455
+E AP ++ + G + C V+ P + WR + +P + + Y
Sbjct: 328 TVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING--IPVEELAKDQKYRIQ 385
Query: 456 RKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPS 497
R ++ ++ +D C A N G + + +P+
Sbjct: 386 RGALI-LSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPA 426
Score = 35.8 bits (81), Expect = 0.17
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 1/84 (1%)
Query: 552 TMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKL 611
T V+L+ L P ++Y + V A NG+G G S+ F T P ++H + S S L
Sbjct: 878 TSVILSGLRPYSSYHLEVQAFNGRGSGPASEF-TFSTPEGVPGHPEALHLECQSNTSLLL 936
Query: 612 SITKQDDGGAPILEYIVKYRSKDK 635
+ Y++ Y D+
Sbjct: 937 RWQPPLSHNGVLTGYVLSYHPLDE 960
Score = 31.6 bits (70), Expect = 3.2
Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 14/178 (7%)
Query: 313 YENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKL 372
+ ++L C+A G+P + W R DG F + + L + GS ++ +
Sbjct: 48 FPTDDISLKCEASGKPEVQFRWTR--DGVHF-KPKEELGVTVYQSPHSGSFTITGNNSNF 104
Query: 373 SD--SGRYDCEAASRIG-GHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCD-VKS 426
+ G Y C A++++G + L E APK+ +T+ EG + + C+ S
Sbjct: 105 AQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW-PKETVKPVEVEEGESVVLPCNPPPS 163
Query: 427 NPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
P I+W K +L K + G + TSDN Y C A + GTR
Sbjct: 164 AEPLRIYWMNSK-ILHIKQDERVTMGQNGNLYFANVL-TSDN-HSDYICHA-HFPGTR 217
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 148 bits (374), Expect = 2e-35
Identities = 163/691 (23%), Positives = 279/691 (40%), Gaps = 67/691 (9%)
Query: 26 SLSKVELSVGESKFFTCTA--IGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNA 83
++ VE+ GES C EP I W N + I +RV + + G +Y A
Sbjct: 142 TVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNG-----NLYFA 196
Query: 84 NI---EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK------------Q 128
N+ ++ Y C A +T +++ K T + Q
Sbjct: 197 NVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ 256
Query: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG 188
G+ + C P P + WL + + +D N LQ+L + + D+G YRC
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSGPMP--ADRVTYQNHNKTLQLLKVGEEDDGEYRCLA 314
Query: 189 RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNG 248
+ G + + P + PQ GE C+ G P+P ++W NG
Sbjct: 315 E-NSLGSARHAYYVTVEAAPYWLHKPQSHLYGP---GETARLDCQVQGRPQPEVTWRING 370
Query: 249 KLIEE---NEKY-ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI 304
+EE ++KY I +G+ L + N+ SD C A N+ G A++ V P
Sbjct: 371 IPVEELAKDQKYRIQRGA---LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 427
Query: 305 IQLKNETTY---ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHG 361
I + TY + L+C A G P+P + W DG T + ++ +
Sbjct: 428 ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDE-DGTTVLQDERFFP--------YA 478
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
+ +L I+D++ +D+GRY C AA+ L ++ A + +G+ + +
Sbjct: 479 NGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFT 538
Query: 422 CDVKSNPPA--SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
C +P SI WR D L ++ GR +I + +D G Y+C A+
Sbjct: 539 CQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSL---DYSDQGNYSCVAST 595
Query: 480 HIGTRFQEYILALADVPSSPYGVKIIEL---SQTTAKVSFNKPDSHGGVPIHHYQVDV-- 534
+ L + P + + +L +Q+ +VS++ + H PI Y ++
Sbjct: 596 ELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNA-PIEKYDIEFED 654
Query: 535 KEVASEIW-KIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVRE 593
KE+A E W + + G QT L L P Y RV A+N G G+ S + P
Sbjct: 655 KEMAPEKWYSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAA 713
Query: 594 PSPPSIHGQPSSGKSFKLSIT----KQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD 649
P + + ++ + IT + D AP ++Y V++R + W E+ V +
Sbjct: 714 PEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIV--SDP 771
Query: 650 HIILEHLQWTMGYEVQITAANRLGYS-EPTV 679
+++ + + YE+++ A N G EP V
Sbjct: 772 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQV 802
Score = 116 bits (291), Expect = 8e-26
Identities = 165/685 (24%), Positives = 261/685 (38%), Gaps = 88/685 (12%)
Query: 42 CTAIGEPESIDWYNPQGEKIISTQR--VVVQKEGVRSRLTIYNANIEDA----GIYRCQA 95
C A G+PE + G + V V + TI N A GIYRC A
Sbjct: 57 CEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFA 116
Query: 96 TDAKG--QTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNE 153
++ G + E ++ E K +E V P E ++GE + C S P + +++
Sbjct: 117 SNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSK 175
Query: 154 EVTTISDNRFAMLANNNLQILNINKSD-EGIYRCEGRVEARGEIDFRDII---------V 203
+ D R M N NL N+ SD Y C I ++ I +
Sbjct: 176 ILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSM 235
Query: 204 IVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFR-NGKLIEENEKYILKGS 262
I P + S + A +G+ + C A G P P I W R +G + + Y +
Sbjct: 236 IDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTY--QNH 293
Query: 263 NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVT-LV 321
N L + + D G Y C A N G ++ V P+ + Y G+ L
Sbjct: 294 NKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLD 353
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 381
C +G P PE+TW+ ++G E K RI+ +L + +V+ SD+ CE
Sbjct: 354 CQVQGRPQPEVTWR--INGIPVEELAKDQKYRIQ------RGALILSNVQPSDTMVTQCE 405
Query: 382 AASRIGGHQKSMYLDIEYAPKFI---SNQTIYYSWEGNPINISCDVKSNPPASIHWRRDK 438
A +R G + Y+ + P I NQT Y + +G+ + C P S+ W
Sbjct: 406 ARNRHGLLLANAYIYVVQLPAKILTADNQT-YMAVQGSTAYLLCKAFGAPVPSVQW---- 460
Query: 439 LVLPAKNTTNLK-----TYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALA 493
L TT L+ Y+ G L I ND GRY C A N L +
Sbjct: 461 --LDEDGTTVLQDERFFPYANG---TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVK 515
Query: 494 DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
D G + + + ++V+F S D S W R G
Sbjct: 516 DATQITQGPR-STIEKKGSRVTFTCQAS----------FDPSLQPSITW---RGDGRD-- 559
Query: 554 VVLNNLEPNTTYEIR-----VAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPS---- 604
L L + Y I + +++ QG+YS + + V + + G P
Sbjct: 560 --LQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPR 617
Query: 605 ---------SGKSFKLSITKQDDGGAPILEYIVKYRSKD-KEDQWLE-KKVQGNKDHIIL 653
+ ++S + +D API +Y +++ K+ ++W KV GN+ L
Sbjct: 618 LVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL 677
Query: 654 EHLQWTMGYEVQITAANRLGYSEPT 678
+ L + Y ++TA N+ G EP+
Sbjct: 678 K-LSPYVHYTFRVTAINKYGPGEPS 701
Score = 107 bits (266), Expect = 6e-23
Identities = 167/703 (23%), Positives = 268/703 (38%), Gaps = 67/703 (9%)
Query: 20 LLQVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRL 78
LL T S S + G+ C A G P +I W P G + RV Q L
Sbjct: 242 LLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGP--MPADRVTYQNHN--KTL 297
Query: 79 TIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRV 138
+ ED G YRC A ++ G + A V + S + GE A + C+V
Sbjct: 298 QLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQS-HLYGPGETARLDCQV 356
Query: 139 SSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDF 198
P P V+W + V ++ ++ + L + N+ SD + +CE R G +
Sbjct: 357 QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEAR-NRHGLLLA 415
Query: 199 RDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWF-RNGKLIEENEKY 257
I +V +P I + + A +G C+A G+P P++ W +G + ++E++
Sbjct: 416 NAYIYVVQLPAKI-LTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 474
Query: 258 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENG- 316
+ T L +R++ +D G Y C A N A L+V I Q T + G
Sbjct: 475 FPYANGT-LGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGS 533
Query: 317 QVTLVCDAEGEPI--PEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSD 374
+VT C A +P P ITW+ DG E S IE L I + SD
Sbjct: 534 RVTFTCQASFDPSLQPSITWRG--DGRDLQELGDSDKYFIE------DGRLVIHSLDYSD 585
Query: 375 SGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCDVKSNPPASI 432
G Y C A++ + + L + +P + + + + + +S + A I
Sbjct: 586 QGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI 645
Query: 433 HWR----RDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG----TR 484
DK + P K + K L+++P F TA N G +
Sbjct: 646 EKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSP 702
Query: 485 FQEYILALADVP-SSPYGVKIIELSQTTAKVSFNKP--DSHGGVPIHHYQVDVKEVASEI 541
E ++ P +P VK E ++TT V KP P Y+V
Sbjct: 703 VSETVVTPEAAPEKNPVDVK-GEGNETTNMVITWKPLRWMDWNAPQVQYRVQ-------- 753
Query: 542 WKIVRSHG-------VQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI---FQTLPV 591
W+ + G +V++N YEI+V AVN +G+G ++ I + P
Sbjct: 754 WRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQ 813
Query: 592 REPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDH- 650
P I SS K + Y V Y + + + ++ + +KDH
Sbjct: 814 AIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI--HKDHV 871
Query: 651 --------IILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMP 685
+IL L+ Y +++ A N G + + FS P
Sbjct: 872 VVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTP 914
Score = 76.6 bits (187), Expect = 9e-14
Identities = 80/402 (19%), Positives = 147/402 (36%), Gaps = 60/402 (14%)
Query: 130 EDAEVVCRVSSSPAPAVSWL-----YHNEEVTTIS------DNRFAMLANNNLQILNINK 178
+D + C S P W + +E ++ F + NN+ N +
Sbjct: 51 DDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNS----NFAQ 106
Query: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNAT-AERGEEMTFSCRASGS 237
+GIYRC + + ++ P P+++ E GE + C S
Sbjct: 107 RFQGIYRCFASNKLGTAMSHEIRLMAEGAP---KWPKETVKPVEVEEGESVVLPCNPPPS 163
Query: 238 PEPAISWFRNGKLIE-ENEKYILKGSNTELTVRNIINSDG-GPYVC-------------- 281
EP ++ N K++ + ++ + G N L N++ SD Y+C
Sbjct: 164 AEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKE 223
Query: 282 ------RATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWK 335
+ATN + + + H++ L+ + + L C AEG P P I W
Sbjct: 224 PIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQP------LVLECIAEGFPTPTIKWL 277
Query: 336 RAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYL 395
R G D V Q+ + +L + V D G Y C A + +G + + Y+
Sbjct: 278 RP-------SGPMPAD---RVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYV 327
Query: 396 DIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTG 455
+E AP ++ + G + C V+ P + WR + +P + + Y
Sbjct: 328 TVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING--IPVEELAKDQKYRIQ 385
Query: 456 RKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPS 497
R ++ ++ +D C A N G + + +P+
Sbjct: 386 RGALI-LSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPA 426
Score = 35.8 bits (81), Expect = 0.17
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 1/84 (1%)
Query: 552 TMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKL 611
T V+L+ L P ++Y + V A NG+G G S+ F T P ++H + S S L
Sbjct: 878 TSVILSGLRPYSSYHLEVQAFNGRGSGPASEF-TFSTPEGVPGHPEALHLECQSNTSLLL 936
Query: 612 SITKQDDGGAPILEYIVKYRSKDK 635
+ Y++ Y D+
Sbjct: 937 RWQPPLSHNGVLTGYVLSYHPLDE 960
Score = 31.6 bits (70), Expect = 3.2
Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 14/178 (7%)
Query: 313 YENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKL 372
+ ++L C+A G+P + W R DG F + + L + GS ++ +
Sbjct: 48 FPTDDISLKCEASGKPEVQFRWTR--DGVHF-KPKEELGVTVYQSPHSGSFTITGNNSNF 104
Query: 373 SD--SGRYDCEAASRIG-GHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCD-VKS 426
+ G Y C A++++G + L E APK+ +T+ EG + + C+ S
Sbjct: 105 AQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW-PKETVKPVEVEEGESVVLPCNPPPS 163
Query: 427 NPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
P I+W K +L K + G + TSDN Y C A + GTR
Sbjct: 164 AEPLRIYWMNSK-ILHIKQDERVTMGQNGNLYFANVL-TSDN-HSDYICHA-HFPGTR 217
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 148 bits (374), Expect = 2e-35
Identities = 146/613 (23%), Positives = 253/613 (41%), Gaps = 70/613 (11%)
Query: 28 SKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRS---------- 76
S V +S GE C A G P +I+WY +RV K+ RS
Sbjct: 54 SDVIVSKGEPTTLNCKAEGRPTPTIEWYK-------DGERVETDKDDPRSHRMLLPSGSL 106
Query: 77 ---RLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEI-YQKLTFREVVSPQEFKQGEDA 132
R+ + D G Y C A + G+ LE+ + FR+ + GE A
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 166
Query: 133 EVVCRVSSS-PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVE 191
+ C+ P P + W ++V + L I N KSD G+Y C G
Sbjct: 167 ILECQPPRGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVG-TN 223
Query: 192 ARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI 251
GE D + V P ++ N E + F C+ G P+P + W ++ +
Sbjct: 224 MVGERDSDPAELTVFERPTFL--RRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL 281
Query: 252 EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPH-IIQLKNE 310
+Y +K T L ++ +++D G Y+C A N+ G+ E A L V P +++ +++
Sbjct: 282 PRG-RYDIKDDYT-LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ 339
Query: 311 TTYENGQVTLVCDAEGEPIPEITW-KRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKD 369
+ VT C+ +G P P + W K F + + R V + L I +
Sbjct: 340 IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP---TGDLTITN 396
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDI-----EYAPKFI----SNQTIYYSWEGNPINI 420
++ SD+G Y C+A + G L++ + P I +NQT+ + +G + +
Sbjct: 397 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL--AVDGTAL-L 453
Query: 421 SCDVKSNPPASIHWRRDKLVLPAKNT-TNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
C +P I W ++ P ++ ++ T L+I +D G Y C AT+
Sbjct: 454 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT-----LQIKNLRISDTGTYTCVATS 508
Query: 480 HIGTRFQEYILA-------------LADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526
G +L L+D+P P ++ ++++ + +S+ +P + G +P
Sbjct: 509 SSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW-QPGTPGTLP 567
Query: 527 IHHYQVDV-KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI 585
Y ++ + S W+ V +H T+ + L PNT Y V A+N +G D S +
Sbjct: 568 ASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMS- 626
Query: 586 FQTLPVREPSPPS 598
+ ++ SPP+
Sbjct: 627 -DPVRTQDISPPA 638
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/110 (21%), Positives = 45/110 (40%), Gaps = 23/110 (20%)
Query: 387 GGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD--------- 437
G Q S ++ P+ + + + +G P ++C + P +I W +D
Sbjct: 33 GQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKD 92
Query: 438 -----KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
+++LP+ + L+ GR+ S D G Y C A N++G
Sbjct: 93 DPRSHRMLLPSGSLFFLRIVH-GRR--------SKPDEGSYVCVARNYLG 133
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 148 bits (374), Expect = 2e-35
Identities = 146/613 (23%), Positives = 253/613 (41%), Gaps = 70/613 (11%)
Query: 28 SKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRS---------- 76
S V +S GE C A G P +I+WY +RV K+ RS
Sbjct: 38 SDVIVSKGEPTTLNCKAEGRPTPTIEWYK-------DGERVETDKDDPRSHRMLLPSGSL 90
Query: 77 ---RLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEI-YQKLTFREVVSPQEFKQGEDA 132
R+ + D G Y C A + G+ LE+ + FR+ + GE A
Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 150
Query: 133 EVVCRVSSS-PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVE 191
+ C+ P P + W ++V + L I N KSD G+Y C G
Sbjct: 151 ILECQPPRGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVG-TN 207
Query: 192 ARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI 251
GE D + V P ++ N E + F C+ G P+P + W ++ +
Sbjct: 208 MVGERDSDPAELTVFERPTFL--RRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL 265
Query: 252 EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPH-IIQLKNE 310
+Y +K T L ++ +++D G Y+C A N+ G+ E A L V P +++ +++
Sbjct: 266 PRG-RYDIKDDYT-LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ 323
Query: 311 TTYENGQVTLVCDAEGEPIPEITW-KRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKD 369
+ VT C+ +G P P + W K F + + R V + L I +
Sbjct: 324 IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP---TGDLTITN 380
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDI-----EYAPKFI----SNQTIYYSWEGNPINI 420
++ SD+G Y C+A + G L++ + P I +NQT+ + +G + +
Sbjct: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL--AVDGTAL-L 437
Query: 421 SCDVKSNPPASIHWRRDKLVLPAKNT-TNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
C +P I W ++ P ++ ++ T L+I +D G Y C AT+
Sbjct: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT-----LQIKNLRISDTGTYTCVATS 492
Query: 480 HIGTRFQEYILA-------------LADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526
G +L L+D+P P ++ ++++ + +S+ +P + G +P
Sbjct: 493 SSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW-QPGTPGTLP 551
Query: 527 IHHYQVDV-KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEI 585
Y ++ + S W+ V +H T+ + L PNT Y V A+N +G D S +
Sbjct: 552 ASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMS- 610
Query: 586 FQTLPVREPSPPS 598
+ ++ SPP+
Sbjct: 611 -DPVRTQDISPPA 622
Score = 31.6 bits (70), Expect = 3.2
Identities = 21/99 (21%), Positives = 42/99 (42%), Gaps = 23/99 (23%)
Query: 398 EYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD--------------KLVLPA 443
++ P+ + + + +G P ++C + P +I W +D +++LP+
Sbjct: 28 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
Query: 444 KNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
+ L+ GR+ S D G Y C A N++G
Sbjct: 88 GSLFFLRIVH-GRR--------SKPDEGSYVCVARNYLG 117
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 147 bits (371), Expect = 4e-35
Identities = 116/412 (28%), Positives = 172/412 (41%), Gaps = 27/412 (6%)
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
AG Y C A ++ G + V L + + + S E+ + C S P P ++
Sbjct: 2640 AGRYTCSARNSAGVAHKH-VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTIT 2698
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNV 207
W V T + +L L+I + + D G Y C + A + ++V V
Sbjct: 2699 WQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV--QV 2754
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT 267
PP I + T G C+A GSPEP I+W ++G+ + E + EL
Sbjct: 2755 PPVIENGLPDLSTT--EGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELL 2812
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENG-QVTLVCDAEG 326
V+N+ D G Y C A N G ++ L + V P L + + G ++ L C A G
Sbjct: 2813 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARG 2872
Query: 327 EPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRI 386
P P I W V+ TEG V Q G S+L V DSG Y C A +R+
Sbjct: 2873 SPTPRIGW--TVNDRPVTEG---------VSEQDGGSTLQRAAVSREDSGTYVCWAENRV 2921
Query: 387 GGHQKSMYLDIEYAPKFISNQTIYYSWE--GNPINISCDVKSNPPASIHWRRDKLVLPAK 444
G Q ++ ++ AP + + Y E G I + C V+ +P IHW +D L L
Sbjct: 2922 GRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGS 2980
Query: 445 NTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ + + L I T +D GRY C A N +G + IL L P
Sbjct: 2981 HLRHQLQNGS-----LTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP 3027
Score = 144 bits (362), Expect = 4e-34
Identities = 129/500 (25%), Positives = 210/500 (42%), Gaps = 52/500 (10%)
Query: 30 VELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V + VG+ +C PE ++ WY G+ ++ QR + G RL I A + D
Sbjct: 1760 VLVRVGDKAVLSCETDALPEPTVTWYK-DGQPLVLAQRTQALRGG--QRLEIQEAQVSDK 1816
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFR----EVVSPQEFKQGEDAEVVCRVSSSPAP 144
G+Y C+ ++ G+ T L + TF E VS G + C VS PAP
Sbjct: 1817 GLYSCKVSNVAGEAVR-TFTLTVQVPPTFENPKTETVSQVA---GSPLVLTCDVSGVPAP 1872
Query: 145 AVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG---RVEARGEIDFRDI 201
V+WL V + S + LQ+ + + G Y C + EAR +D
Sbjct: 1873 TVTWLKDRMPVES-SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR-----KDF 1926
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE----KY 257
+V V V P I + G+E+ C A G P P ++W ++G + ++ ++
Sbjct: 1927 VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 1986
Query: 258 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNET----TY 313
L G + L ++ + SD G Y C A N AGED + + V V P I Q + + +
Sbjct: 1987 YLDGGS--LVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSR 2044
Query: 314 ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS-SLHIKDVKL 372
VT+VC G P ++W + DG ++L HGS +L I V+L
Sbjct: 2045 PGELVTMVCPVRGSPPIHVSWLK--DGLPLPLSQRTL--------LHGSGHTLRISKVQL 2094
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDIEYAPKF--ISNQTIYYSWEGNPINISCDVKSNPPA 430
+D+G + C AAS G ++ L ++ P + Q G+ + + C+ + P
Sbjct: 2095 ADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP 2154
Query: 431 SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
+ W +D L + S + L++ D G Y+C A + G + + L
Sbjct: 2155 LVSWMKDG--------EPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQL 2206
Query: 491 ALADVPSSPYGVKIIELSQT 510
+ + P + ELS T
Sbjct: 2207 TVMEPPHIEDSGQPTELSLT 2226
Score = 142 bits (359), Expect = 1e-33
Identities = 117/467 (25%), Positives = 199/467 (42%), Gaps = 35/467 (7%)
Query: 42 CTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKG 100
C A G P + W+ + + S V V +G L I A + DAG YRC A++ G
Sbjct: 625 CLASGVPPPDVSWFKGH-QPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYRCVASNVAG 681
Query: 101 QTQ-EATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIS 159
T+ + + + ++T + P + C + +P+P + WL V+
Sbjct: 682 STELRYGLRVNVPPRITLPPSL-PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAG 740
Query: 160 DNRFAMLANNN-LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSF 218
+ L + + SD G Y C V A GE D +D+++ V++PP+I +
Sbjct: 741 TPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGE-DRQDVVLQVHMPPSIL--GEEL 796
Query: 219 NATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGP 278
N + E + C++ P P +SW+++G+ +E L L V D G
Sbjct: 797 NVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGH 856
Query: 279 YVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE---TTYENGQVTLVCDAEGEPIPEITWK 335
Y C A N+AG EK L V+V P + L+ T E L C+ G P P+I+W+
Sbjct: 857 YTCEALNQAGHSEKHYNLNVWVAP-VFPLRESHTLTVREGHPTRLSCECRGVPFPKISWR 915
Query: 336 RAVDGFTFTEGDKSLDGRIEVKGQHGSS---SLHIKDVKLSDSGRYDCEAASRIGGHQKS 392
+ DG L QH S+ L++ +L+ G Y CE ++ +G +
Sbjct: 916 K--DGQPLPGEGAGL--------QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 965
Query: 393 MYLDIEYAPKFISNQ---TIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNL 449
+ L++ P+ + T + + C+ PP ++ W RD P L
Sbjct: 966 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG--QPVGAELGL 1023
Query: 450 KTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ + G+ + +E A + GRY+C A N G +++ L++ P
Sbjct: 1024 QLQNQGQSLHVERAQAAHT--GRYSCVAENLAGRAERKFELSVLVPP 1068
Score = 138 bits (347), Expect = 2e-32
Identities = 123/485 (25%), Positives = 210/485 (43%), Gaps = 37/485 (7%)
Query: 12 LLVSSGQALLQVTISL-SKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVV 69
LLV + +L T L +V ++ + C A+G P +I W G + R+ V
Sbjct: 1554 LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQ-NGLPFSPSPRLQV 1612
Query: 70 QKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEA-TVVLEIYQKLTFREVVSPQEFKQ 128
++G L + A + DA Y C A + G ++ T+ +++ ++ ++
Sbjct: 1613 LEDG--QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1670
Query: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG 188
+ C V + P P V+W Y + + ++ + F + + LQ+ SD G+Y CE
Sbjct: 1671 SS-VSLPCDVHAHPNPEVTW-YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 1728
Query: 189 RVEARGEIDFRDIIVIVNVPPAISM-PQKSFNATAER-GEEMTFSCRASGSPEPAISWFR 246
+ A G D + + + V VPPA P+ +A R G++ SC PEP ++W++
Sbjct: 1729 -LNAAGR-DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 1786
Query: 247 NGK-LIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII 305
+G+ L+ L+G L ++ SD G Y C+ +N AGE + L V V P
Sbjct: 1787 DGQPLVLAQRTQALRGGQ-RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFE 1845
Query: 306 QLKNETTYE--NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS 363
K ET + + L CD G P P +TW + D+ +E HG
Sbjct: 1846 NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK----------DRM---PVESSAVHGVV 1892
Query: 364 S----LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNP 417
S L + ++ + +G Y C A + +K + + AP+ S+ ++ EG
Sbjct: 1893 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQE 1952
Query: 418 INISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTA 477
+ + C+ PP + W +D L +L+ Y G ++L+ S D G Y C A
Sbjct: 1953 VRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRAS--DAGAYTCVA 2010
Query: 478 TNHIG 482
N G
Sbjct: 2011 HNPAG 2015
Score = 132 bits (331), Expect = 2e-30
Identities = 131/510 (25%), Positives = 195/510 (38%), Gaps = 59/510 (11%)
Query: 35 GESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G +C G P I W G+ + + V L + A + G Y C
Sbjct: 895 GHPTRLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 953
Query: 94 QATDAKGQTQEATVVLEIY---QKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLY 150
+ ++ G + + + LE++ Q RE + Q A + C + P P V+W
Sbjct: 954 ECSNVVGNSSQ-DLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 1012
Query: 151 HNEEVTTISDNRFAMLANNNLQILNINKSDE---GIYRC-----EGRVEARGEIDFRDII 202
+ V + N Q L++ ++ G Y C GR E + E+
Sbjct: 1013 DGQPVGA----ELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELS----- 1063
Query: 203 VIVNVPPA-ISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG 261
V VPP I N TA +T C A G P PAI WFR + + E L
Sbjct: 1064 --VLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA 1121
Query: 262 SNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYE-----NG 316
L + D G Y C A+N+AGE + ++V V P I +NE E +G
Sbjct: 1122 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI---ENEDLEEVIKVLDG 1178
Query: 317 QVT-LVCDAEGEPIPEITWKRAVDGFTFTEGDK---SLDGRIEVKGQHGSSSLHIKDVKL 372
Q L+C+ G P P++TW + DG GD S DG + L + L
Sbjct: 1179 QTAHLMCNVTGHPQPKLTWFK--DGRPLARGDAHHISPDGVL----------LQVLQANL 1226
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE-----GNPINISCDVKSN 427
S +G Y C AA+ +G K L + AP + E NPI++ C+ +
Sbjct: 1227 SSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAF 1286
Query: 428 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
P +I W +D A L + G L+I D G+Y C TN +G +
Sbjct: 1287 PSPNITWMKDGAPFEASRNIQLLPGTHG----LQILNAQKEDAGQYTCVVTNELGEAVKN 1342
Query: 488 YILALADVPSSPYGVKIIELSQTTAKVSFN 517
Y + + PS + E+ K N
Sbjct: 1343 YHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372
Score = 130 bits (326), Expect = 7e-30
Identities = 120/489 (24%), Positives = 212/489 (43%), Gaps = 43/489 (8%)
Query: 30 VELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V+ G C A G P ++ W++ +G + + ++ +G S L + + +
Sbjct: 324 VKAVAGRPVALECVARGHPSPTLSWHH-EGLPVAESNESRLETDG--SVLRLESPGEASS 380
Query: 89 GIYRCQATDAKGQTQ-EATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
G+Y C A+ G+ + +V +++ +L E + G+ E+ C+ S SP P +
Sbjct: 381 GLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 440
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN- 206
WL + ++ + A L I ++ G++ C+ EA ++ V V+
Sbjct: 441 WLQNGRPAEELAGVQVAS-QGTTLHIDHVELDHSGLFACQATNEAGTA--GAEVEVSVHG 497
Query: 207 --VPPAISMPQKSFNATAERGEEMTFSC-----RASGS-PEPAI--SWFRNGKLIEENEK 256
P + +P ++ E +C R G+ P+P + W G L E
Sbjct: 498 EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG 557
Query: 257 YILKGS-NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ-LKNETTYE 314
+ S L + + D G Y C ATN AGE +++ L+V V P+I N+ E
Sbjct: 558 IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLE 617
Query: 315 NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEG-DKSLDGRIEVKGQHGSSSLHIKDVKLS 373
N VTL C A G P P+++W + + G S+DGR+ L I+ +LS
Sbjct: 618 NASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------LRIEQAQLS 667
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEG-----NPINISCDVKSNP 428
D+G Y C A++ G + L + P+ T+ S G P+ ++C+ P
Sbjct: 668 DAGSYRCVASNVAGSTELRYGLRVNVPPRI----TLPPSLPGPVLVNTPVRLTCNATGAP 723
Query: 429 PASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
++ W +D + T L+ + GR +L +A +D GRY+C A + +G Q+
Sbjct: 724 SPTLMWLKDGNPVSPAGTPGLQVFPGGR--VLTLASARASDSGRYSCVAVSAVGEDRQDV 781
Query: 489 ILALADVPS 497
+L + PS
Sbjct: 782 VLQVHMPPS 790
Score = 129 bits (323), Expect = 1e-29
Identities = 116/457 (25%), Positives = 185/457 (40%), Gaps = 38/457 (8%)
Query: 35 GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G TC G P ++ W + S VV + G RL + AG Y C
Sbjct: 1857 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG---RLQLSRLQPAQAGTYTC 1913
Query: 94 QATDAKGQTQEATVV-LEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHN 152
A + + + ++ VV + + ++ V +G++ + C P P V+WL
Sbjct: 1914 VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDG 1973
Query: 153 EEV-TTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAI 211
+ + + L +L + + SD G Y C A GE D R V V VPP I
Sbjct: 1974 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA-GE-DARLHTVNVLVPPTI 2031
Query: 212 SMPQKSFNATAER-GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRN 270
R GE +T C GSP +SW ++G + +++ +L GS L +
Sbjct: 2032 KQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISK 2091
Query: 271 IINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI--IQLKNETTYENGQ-VTLVCDAEGE 327
+ +D G + C A + AG ++ LQV V P + ++ +N+ G V L C+A G
Sbjct: 2092 VQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV 2151
Query: 328 PIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG 387
P+P ++W + +G+ L +E SL ++ V DSG Y C A S G
Sbjct: 2152 PLPLVSWMK--------DGEPLLSQSLE-----QGPSLQLEAVGAGDSGTYSCVAVSEAG 2198
Query: 388 GHQKSMYLDIEYAPKF--ISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN 445
++ L + P T G P+ + CD + P +I W +D L
Sbjct: 2199 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL---- 2254
Query: 446 TTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
T L+ S +++ D G Y C A + G
Sbjct: 2255 -TRLENNSRATRVL------RVRDAGLYTCLAESPAG 2284
Score = 129 bits (323), Expect = 1e-29
Identities = 114/476 (23%), Positives = 190/476 (39%), Gaps = 28/476 (5%)
Query: 28 SKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIED 87
S V E C A G P + +G + + V G +L I +A+ ED
Sbjct: 2673 SVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG---QLRIAHASPED 2729
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
AG Y C A ++ G T ++ + + +G A + C+ SP P ++
Sbjct: 2730 AGNYLCIAKNSAGSAMGKTRLV-VQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT 2788
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNV 207
W + V+ ++ +F + + L + N+ D G Y C A G R + I+ +
Sbjct: 2789 WDKDGQPVSG-AEGKFTIQPSGELLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVL 2846
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT 267
P ++P + + G+ + C A GSP P I W N + + E GS +
Sbjct: 2847 PVFTTLPG---DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRA 2903
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYE--NGQVTLVCDAE 325
+ D G YVC A N+ G + +F+ V P + E G + L C
Sbjct: 2904 A--VSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 2961
Query: 326 GEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASR 385
G+P+P+I W + DG ++ Q + SL I+ + D+GRY C A +
Sbjct: 2962 GDPVPDIHWIK--DGLPLRGS--------HLRHQLQNGSLTIRRTERDDAGRYQCLAENE 3011
Query: 386 IGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN 445
+G +K + L ++ AP F G+ + + C P +I W + P +
Sbjct: 3012 MGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL--QAGQPLRA 3069
Query: 446 TTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG 501
+ L+T G L + D G Y+C A N +G+ L + P +G
Sbjct: 3070 SRRLRTLPDGS---LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWG 3122
Score = 125 bits (314), Expect = 2e-28
Identities = 126/520 (24%), Positives = 211/520 (40%), Gaps = 72/520 (13%)
Query: 35 GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G++ C G P+ + W+ G + + +GV L + AN+ AG Y C
Sbjct: 1178 GQTAHLMCNVTGHPQPKLTWFK-DGRPLARGDAHHISPDGVL--LQVLQANLSSAGHYSC 1234
Query: 94 QATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEV--------VCRVSSSPAPA 145
A +A G E T ++ L ++ E E+ V +C + P+P
Sbjct: 1235 IAANAVG---EKTKHFQL-SVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN 1290
Query: 146 VSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIV 205
++W+ S N + + LQILN K D G Y C E + ++ V V
Sbjct: 1291 ITWMKDGAPFEA-SRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAV--KNYHVEV 1347
Query: 206 NVPPAISMPQKSFNATAER-----GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK 260
+PP+IS + +T C + P P I W+++G+ + + + +
Sbjct: 1348 LIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVL 1407
Query: 261 GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP------------HIIQLK 308
G L ++ SD G Y+C ATN AGED++ + + V P I+ +
Sbjct: 1408 GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 1467
Query: 309 NE-----TTY----ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQ 359
E T Y EN L CD P P++TW R D+ L EV
Sbjct: 1468 EEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE---------DQPLSAGDEVSVL 1518
Query: 360 HGSSSLHIKDVKLSDSGRYDCEAASRIGG---HQKSMYLD----IEYAPKFISNQTIYYS 412
G L I V+ ++GRY C+A++ +G H + + L + + + T+ S
Sbjct: 1519 QGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 1578
Query: 413 WEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGR 472
+ +++ C NP +I W ++ LP + L+ G+ +L+++ D
Sbjct: 1579 ---STVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQ--VLQVSTAEVADAAS 1631
Query: 473 YNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTA 512
Y C A N G+ + + L + VP G ++L Q TA
Sbjct: 1632 YMCVAENQAGSAEKLFTLRV-QVPPRIAG---LDLEQVTA 1667
Score = 125 bits (313), Expect = 2e-28
Identities = 102/404 (25%), Positives = 164/404 (40%), Gaps = 22/404 (5%)
Query: 87 DAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK-QGEDAEVVCRVSSSPAPA 145
D+G+Y C+A + G Q +L + + + G D E+ C S P P
Sbjct: 98 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ 157
Query: 146 VSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIV 205
V W + V + L+I + DEG Y+C A + RD + V
Sbjct: 158 VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA--RDFQLRV 215
Query: 206 NVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTE 265
+ PP I ++ + C A G P P I+WF++G L+ + K + +
Sbjct: 216 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ 275
Query: 266 LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE----TTYENGQVTLV 321
L + +SD G Y C+A+N G EK L V+V P I V L
Sbjct: 276 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALE 335
Query: 322 CDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 381
C A G P P ++W +G E ++S R+E G S L ++ + SG Y C
Sbjct: 336 CVARGHPSPTLSWHH--EGLPVAESNES---RLETDG----SVLRLESPGEASSGLYSCV 386
Query: 382 AASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCDVKSNPPASIHWRRDKL 439
A+S G ++++ P+ + + + + G P+ + C +P +I W ++
Sbjct: 387 ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG- 445
Query: 440 VLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
PA+ ++ S G L I + G + C ATN GT
Sbjct: 446 -RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGT 486
Score = 119 bits (297), Expect = 2e-26
Identities = 127/498 (25%), Positives = 192/498 (38%), Gaps = 41/498 (8%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLT 79
L V L +V VG+ C A G P +I W G V V +G + L
Sbjct: 408 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQ-NGRPAEELAGVQVASQG--TTLH 464
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSP-QEFKQGEDAEVVCRV 138
I + ++ +G++ CQAT+ G T A V + ++ + + P ++ G +
Sbjct: 465 IDHVELDHSGLFACQATNEAG-TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPA 523
Query: 139 SSSPAPAVSWLYHNE---------------EVTTISDNRFAMLANNNLQILNINKSDEGI 183
+ P W H + E T I A LQI ++ DEGI
Sbjct: 524 ACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP---VAYSLPPPLQIEKVDLRDEGI 580
Query: 184 YRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS 243
Y C GE R++ + V VPP I N +T C ASG P P +S
Sbjct: 581 YTCAA-TNLAGESK-REVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVS 636
Query: 244 WFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPH 303
WF+ + + + L + SD G Y C A+N AG E + L+V V P
Sbjct: 637 WFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPR 696
Query: 304 IIQLKN--ETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHG 361
I + N V L C+A G P P + W + DG S G ++ G
Sbjct: 697 ITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK--DG-----NPVSPAGTPGLQVFPG 749
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
L + + SDSGRY C A S +G ++ + L + P + + + +
Sbjct: 750 GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALE 809
Query: 422 CDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHI 481
C + PP + W +D L + +L + K +L++ D G Y C A N
Sbjct: 810 CQSHAMPPPVLSWWKDGRPLEPRPGVHL----SADKALLQVDRADVWDAGHYTCEALNQA 865
Query: 482 GTRFQEYILALADVPSSP 499
G + Y L + P P
Sbjct: 866 GHSEKHYNLNVWVAPVFP 883
Score = 112 bits (281), Expect = 1e-24
Identities = 127/533 (23%), Positives = 208/533 (39%), Gaps = 55/533 (10%)
Query: 7 FYLLGLLVSS--GQALLQVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIIS 63
F+LL L S G Q + L+ ++ + C G P ++W + +
Sbjct: 117 FHLLVLTPPSVLGAGAAQEVLGLAGADVEL------QCWTSGVPTPQVEWTKDRQPVLPG 170
Query: 64 TQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSP 123
+ VQ++G R+T +++ D G Y+C A GQ Q L ++ T
Sbjct: 171 GPHLQVQEDGQVLRIT--GSHVGDEGRYQCVAFSPAGQ-QARDFQLRVHAPPTIWGSNET 227
Query: 124 QEFKQGED--AEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDE 181
E ED +++C P P ++W + + + S LQ+ SD
Sbjct: 228 GEVAVMEDHLVQLLCEARGVPTPNITW-FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDA 286
Query: 182 GIYRCE-----GRVEARGEIDFRDIIVIVNVPPAI-SMPQKSFNATAERGEEMTFSCRAS 235
G+Y C+ G E +D V VPP I + + A G + C A
Sbjct: 287 GVYTCKASNAVGAAEKATRLD-------VYVPPTIEGAGGRPYVVKAVAGRPVALECVAR 339
Query: 236 GSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
G P P +SW G + E+ + L+ + L + + + G Y C A++ AGE Q
Sbjct: 340 GHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYS 399
Query: 296 LQVFVQPHII---QLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDG 352
++V V P ++ L TT + L C A G P+P I W + + +
Sbjct: 400 VEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW---------LQNGRPAEE 450
Query: 353 RIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG--GHQKSMYLDIEYAPKFISNQTIY 410
V+ ++LHI V+L SG + C+A + G G + + + E+AP +
Sbjct: 451 LAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQ 510
Query: 411 YSWEGNPINISCDVKSNPPASIHW---RRDKLVLPAKNTTNLKTYSTGRKMI------LE 461
Y W G + S +PP W + LV + +L TG + L+
Sbjct: 511 YHW-GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQ 569
Query: 462 IAPTSDNDFGRYNCTATNHIGTRFQEY---ILALADVPSSPYGVKIIELSQTT 511
I D G Y C ATN G +E +L ++ P ++E + T
Sbjct: 570 IEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVT 622
Score = 110 bits (276), Expect = 4e-24
Identities = 115/513 (22%), Positives = 201/513 (39%), Gaps = 54/513 (10%)
Query: 28 SKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIED 87
+++ L+ G C A G P+ ++ G+ + + SR T + D
Sbjct: 2221 TELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLEN--------NSRATRV-LRVRD 2271
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQ--EFKQG---EDAEVVCRVSSSP 142
AG+Y C A G +++ V + +V P+ F G + C V + P
Sbjct: 2272 AGLYTCLAESPAGAIEKSFRV----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP 2327
Query: 143 APAVSWLYHNEEVTTISDNRFAMLANNN-LQILNINKSDEGIYRCEGRVEARG-----EI 196
AP ++W H + + D LQ+ ++ +D G Y C R A +
Sbjct: 2328 APKITW--HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 2385
Query: 197 DFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK 256
+ + I + PPA+++ S N TA C+A G P P +SW ++ ++
Sbjct: 2386 EIHTVPTIRSGPPAVNV---SVNQTA------LLPCQADGVPAPLVSWRKDRVPLDPRSP 2436
Query: 257 YILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQL-KNETTYEN 315
L ++ ++ D G Y+C A+N AG D + L+V P I N T +
Sbjct: 2437 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496
Query: 316 GQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH--GSSSLHIKDVKLS 373
L C+A G P P + W + +G K LD R++ S++L +
Sbjct: 2497 TPALLPCEASGSPKPLVVW--------WKDGQK-LDFRLQQGAYRLLPSNALLLTAPGPQ 2547
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIH 433
DS +++C ++ +G + + + P +QT + P+ ++C P ++
Sbjct: 2548 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2607
Query: 434 WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALA 493
W + L A+ + Y LEI GRY C+A N G + L
Sbjct: 2608 WSKAGAQLGARGS----GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLT-- 2661
Query: 494 DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526
V +SP + + + A+ P G+P
Sbjct: 2662 -VQASPVVKPLPSVVRAVAEEEVLLPCEASGIP 2693
Score = 99.0 bits (245), Expect = 2e-20
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 31/450 (6%)
Query: 42 CTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQ 101
C A G P + + GE ++S ++G +L A D+G Y C A G+
Sbjct: 2146 CEARGVPLPLVSWMKDGEPLLSQSL----EQGPSLQLEAVGAG--DSGTYSCVAVSEAGE 2199
Query: 102 TQEATVVLEIYQKLTFREVVSPQEFK--QGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIS 159
+ L + + + P E G E++C +P P ++W + +T +
Sbjct: 2200 ARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLE 2258
Query: 160 DNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFN 219
+N A ++L + D G+Y C A G I+ + V V PP I P+
Sbjct: 2259 NNSRAT------RVLRVR--DAGLYTCLAESPA-GAIE-KSFRVRVQAPPNIVGPRGPRF 2308
Query: 220 ATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPY 279
++ C P P I+W R+G +++E+ L ++ + +D G Y
Sbjct: 2309 VVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDY 2368
Query: 280 VCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLV-CDAEGEPIPEITWKRAV 338
C A N AG +++ P I Q L+ C A+G P P ++W++
Sbjct: 2369 SCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK-- 2426
Query: 339 DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
LD R SL I+ V D+G Y C A++ G ++ L +
Sbjct: 2427 -------DRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2479
Query: 399 YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKM 458
P + + P + C+ +P + W +D L + +
Sbjct: 2480 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 2539
Query: 459 ILEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
+L AP D ++ C +N +G + Y
Sbjct: 2540 LL-TAP-GPQDSAQFECVVSNEVGEAHRLY 2567
Score = 98.2 bits (243), Expect = 3e-20
Identities = 83/326 (25%), Positives = 132/326 (40%), Gaps = 40/326 (12%)
Query: 207 VPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI--------------- 251
VPP+I + N + G+ +T C A+G P P I W ++ +L+
Sbjct: 15 VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 74
Query: 252 EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII---QLK 308
+ + L L I D G Y CRA N+AG ++ L V P ++ +
Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 134
Query: 309 NETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIK 368
V L C G P P++ W + + L G ++ Q L I
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTK--------DRQPVLPGGPHLQVQEDGQVLRIT 186
Query: 369 DVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFI--SNQTIYYS-WEGNPINISCDVK 425
+ D GRY C A S G + L + +AP I SN+T + E + + + C+ +
Sbjct: 187 GSHVGDEGRYQCVAFSPAGQQARDFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEAR 245
Query: 426 SNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG--- 482
P +I W +D +LP T+ Y+ G + L++ +D G Y C A+N +G
Sbjct: 246 GVPTPNITWFKDGALLP---TSTKVVYTRGGRQ-LQLGRAQSSDAGVYTCKASNAVGAAE 301
Query: 483 --TRFQEYI-LALADVPSSPYGVKII 505
TR Y+ + PY VK +
Sbjct: 302 KATRLDVYVPPTIEGAGGRPYVVKAV 327
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 147 bits (371), Expect = 4e-35
Identities = 163/686 (23%), Positives = 284/686 (41%), Gaps = 70/686 (10%)
Query: 30 VELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V + G + C A+G P +I W G I ++ + + + V L I N ++DA
Sbjct: 310 VTAAKGTTVKMECFALGNPVPTITWMKVNG--YIPSKARLRKSQAV---LEIPNVQLDDA 364
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSW 148
GIY C+A +++G+ L++Y + E ++ + G C+ + P P W
Sbjct: 365 GIYECRAENSRGK-NSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRW 423
Query: 149 LYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVP 208
L + +S + N L I N+N+SD G+Y+C G I + I+
Sbjct: 424 LKNG---VPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAE-NKYGAIYASAELKILASA 479
Query: 209 PAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTV 268
P ++ Q + +E+ C+ GSP+P ISW + + + EN++ + + L +
Sbjct: 480 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGS-LRI 538
Query: 269 RNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGE 327
N SD G YVCR N G E A L V I T G+ + L C A +
Sbjct: 539 LNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHD 598
Query: 328 PIPEITWKRAVDGFTFTEGDKSLDGRIE-VKGQHGSSSLHIKDVKLSDSGRYDCEAASRI 386
++T+ + G ++ G E ++ Q S+ L I+++ L +GRY C +
Sbjct: 599 ASLDVTFYWTLKGQPIDFEEEG--GHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTA 656
Query: 387 GGHQKSMYLDIEYAP--------KFISNQTIYYSW-----EGNPINISCDVKSNPPASIH 433
L + P + I+ T SW +PI+ S ++++ P S+
Sbjct: 657 DSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPIS-SYNLQARSPFSLG 715
Query: 434 WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT---------- 483
W+ K V P T ++++ M +++ P + +F ATN IGT
Sbjct: 716 WQTVKTV-PEIITGDMES-----AMAVDLNPWVEYEF---RVVATNPIGTGDPSTPSRMI 766
Query: 484 RFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWK 543
R E + A S + EL VS + G Y V + + WK
Sbjct: 767 RTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEG----FGYIVAFRPNGTRGWK 822
Query: 544 ---IVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH 600
+ S + + ++ P T +E++V N KG G +S+I + + EPS
Sbjct: 823 EKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAE-GEPS----- 876
Query: 601 GQPSSGKSFKLSITK--------QDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHII 652
P+ K+ +S+++ ++ G P + ++ ++ED K +GN+ +I
Sbjct: 877 AAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI 936
Query: 653 LEHLQWTMGYEVQITAANRLGYSEPT 678
L L+ Y + A N GY P+
Sbjct: 937 LTGLEGNTLYHFTVRAYNGAGYGPPS 962
Score = 118 bits (295), Expect = 3e-26
Identities = 155/624 (24%), Positives = 253/624 (40%), Gaps = 60/624 (9%)
Query: 86 EDAGIYRCQATDAKGQ--TQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSS-SP 142
+D+G Y+C AT+ G ++EAT+ + R S ++G+ ++C SP
Sbjct: 166 KDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGVVLMCSPPPHSP 224
Query: 143 APAVSWLYHNEEVTTISDNR-FAMLANNNLQILNINKSDEGIYRC-------EGRV-EAR 193
SW+++ D+R F NL I + SD G Y C RV
Sbjct: 225 EIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPP 284
Query: 194 GEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEE 253
+ R+ V+ P I + F TA +G + C A G+P P I+W + I
Sbjct: 285 TPLTLRNDGVMGEYEPKIEV-HFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPS 343
Query: 254 NEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTY 313
+ L+ S L + N+ D G Y CRA N G++ + LQV+ PH ++ N+T
Sbjct: 344 KAR--LRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQL 401
Query: 314 ENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKL 372
++G + C A G+P P W + +G S R+E+ + L I +V
Sbjct: 402 DSGSPLRWECKATGKPRPTYRWLK--NGVPL-----SPQSRVEMV----NGVLMIHNVNQ 450
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDI-EYAPKFISNQ---TIYYSWEGNPINISCDVKSNP 428
SD+G Y C A ++ G S L I AP F NQ TI + + + I C + +P
Sbjct: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVT-KDQEVVIECKPQGSP 509
Query: 429 PASIHWRR-DKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
+I W++ D+ V K L S L I S +D G+Y C N G+
Sbjct: 510 KPTISWKKGDRAVRENKRIAILPDGS------LRILNASKSDEGKYVCRGENVFGSAEII 563
Query: 488 YILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHY------QVDVKEVASEI 541
L++ + K EL+ + V K + + Y +D +E
Sbjct: 564 ASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHF 623
Query: 542 WKIVRSHGVQTMVVLNNLEPNT-TYEIRVAAVNGKGQGDYSKIEIFQTLPVR-EPSPPSI 599
I +++ N L + Y RV Q + L VR P PP I
Sbjct: 624 ESIRAQASSADLMIRNILLMHAGRYGCRV-------QTTADSVSDEAELLVRGPPGPPGI 676
Query: 600 -HGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKD----KEDQWLEKKVQGNKDHIILE 654
+ + + LS + D +PI Y ++ RS + + + + + G+ + +
Sbjct: 677 VIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAV 736
Query: 655 HLQWTMGYEVQITAANRLGYSEPT 678
L + YE ++ A N +G +P+
Sbjct: 737 DLNPWVEYEFRVVATNPIGTGDPS 760
Score = 80.1 bits (196), Expect = 8e-15
Identities = 83/384 (21%), Positives = 144/384 (37%), Gaps = 47/384 (12%)
Query: 136 CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
C V +P P+ WL + E+ SD R++++ + D G Y+C G
Sbjct: 123 CEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLA-TNTVGS 181
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCR-ASGSPEPAISWFRN--GKLIE 252
I R+ + S +S + E G+ + C SPE SW N +
Sbjct: 182 ILSREATLQFAYLGNFSGRTRSAVSVRE-GQGVVLMCSPPPHSPEIIYSWVFNEFPSFVA 240
Query: 253 ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE-- 310
E+ + + L + + SD G Y+C N +V P + L+N+
Sbjct: 241 EDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTN------ARVLSPPTPLTLRNDGV 294
Query: 311 ----------------TTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI 354
T + V + C A G P+P ITW + V+G+ +
Sbjct: 295 MGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMK-VNGYIPS---------- 343
Query: 355 EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE 414
+ + + + L I +V+L D+G Y+C A + G + L + P ++
Sbjct: 344 KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDS 403
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G+P+ C P + W ++ + L ++ + +L I + +D G Y
Sbjct: 404 GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV------NGVLMIHNVNQSDAGMYQ 457
Query: 475 CTATNHIGTRFQEYIL-ALADVPS 497
C A N G + L LA P+
Sbjct: 458 CLAENKYGAIYASAELKILASAPT 481
Score = 58.9 bits (141), Expect = 2e-08
Identities = 67/290 (23%), Positives = 113/290 (38%), Gaps = 27/290 (9%)
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT 267
P + P T +++ +C G+P P+ W RNG I+ Y +
Sbjct: 99 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFI 158
Query: 268 VRNIINS-DGGPYVCRATNKAGED-EKQAFLQ-VFVQPHIIQLKNETTYENGQ-VTLVCD 323
+ N + D G Y C ATN G ++A LQ ++ + ++ + GQ V L+C
Sbjct: 159 ISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCS 218
Query: 324 AEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAA 383
PEI + + F + D R + + G +L+I V+ SD G Y C
Sbjct: 219 PPPHS-PEIIYSWVFNEFPSFVAE---DSRRFISQETG--NLYISKVQTSDVGSYICLVK 272
Query: 384 SRIGGHQ----------KSMYLDIEYAPKF-ISNQTIYYSWEGNPINISCDVKSNPPASI 432
+ + + ++ + EY PK + + +G + + C NP +I
Sbjct: 273 NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 332
Query: 433 HWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
W + +P+K + +LEI +D G Y C A N G
Sbjct: 333 TWMKVNGYIPSKARLRKS------QAVLEIPNVQLDDAGIYECRAENSRG 376
Score = 37.7 bits (86), Expect = 0.045
Identities = 31/108 (28%), Positives = 49/108 (45%), Gaps = 10/108 (9%)
Query: 491 ALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGV 550
A DV ++ V I ++ K S +P G + +++ +E +E V++ G
Sbjct: 878 APTDVKATSVSVSEILVAWKHIKESLGRPQ---GFEVGYWKDMEQEDTAET---VKTRGN 931
Query: 551 QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPS 598
++ V+L LE NT Y V A NG G G S + + SPPS
Sbjct: 932 ESFVILTGLEGNTLYHFTVRAYNGAGYGPPSS----EVSATTKKSPPS 975
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 147 bits (371), Expect = 4e-35
Identities = 163/686 (23%), Positives = 284/686 (41%), Gaps = 70/686 (10%)
Query: 30 VELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V + G + C A+G P +I W G I ++ + + + V L I N ++DA
Sbjct: 236 VTAAKGTTVKMECFALGNPVPTITWMKVNG--YIPSKARLRKSQAV---LEIPNVQLDDA 290
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSW 148
GIY C+A +++G+ L++Y + E ++ + G C+ + P P W
Sbjct: 291 GIYECRAENSRGK-NSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRW 349
Query: 149 LYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVP 208
L + +S + N L I N+N+SD G+Y+C G I + I+
Sbjct: 350 LKNG---VPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAE-NKYGAIYASAELKILASA 405
Query: 209 PAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTV 268
P ++ Q + +E+ C+ GSP+P ISW + + + EN++ + + L +
Sbjct: 406 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGS-LRI 464
Query: 269 RNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGE 327
N SD G YVCR N G E A L V I T G+ + L C A +
Sbjct: 465 LNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHD 524
Query: 328 PIPEITWKRAVDGFTFTEGDKSLDGRIE-VKGQHGSSSLHIKDVKLSDSGRYDCEAASRI 386
++T+ + G ++ G E ++ Q S+ L I+++ L +GRY C +
Sbjct: 525 ASLDVTFYWTLKGQPIDFEEEG--GHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTA 582
Query: 387 GGHQKSMYLDIEYAP--------KFISNQTIYYSW-----EGNPINISCDVKSNPPASIH 433
L + P + I+ T SW +PI+ S ++++ P S+
Sbjct: 583 DSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPIS-SYNLQARSPFSLG 641
Query: 434 WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT---------- 483
W+ K V P T ++++ M +++ P + +F ATN IGT
Sbjct: 642 WQTVKTV-PEIITGDMES-----AMAVDLNPWVEYEF---RVVATNPIGTGDPSTPSRMI 692
Query: 484 RFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWK 543
R E + A S + EL VS + G Y V + + WK
Sbjct: 693 RTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEG----FGYIVAFRPNGTRGWK 748
Query: 544 ---IVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH 600
+ S + + ++ P T +E++V N KG G +S+I + + EPS
Sbjct: 749 EKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAE-GEPS----- 802
Query: 601 GQPSSGKSFKLSITK--------QDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHII 652
P+ K+ +S+++ ++ G P + ++ ++ED K +GN+ +I
Sbjct: 803 AAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI 862
Query: 653 LEHLQWTMGYEVQITAANRLGYSEPT 678
L L+ Y + A N GY P+
Sbjct: 863 LTGLEGNTLYHFTVRAYNGAGYGPPS 888
Score = 118 bits (295), Expect = 3e-26
Identities = 155/624 (24%), Positives = 253/624 (40%), Gaps = 60/624 (9%)
Query: 86 EDAGIYRCQATDAKGQ--TQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSS-SP 142
+D+G Y+C AT+ G ++EAT+ + R S ++G+ ++C SP
Sbjct: 92 KDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGVVLMCSPPPHSP 150
Query: 143 APAVSWLYHNEEVTTISDNR-FAMLANNNLQILNINKSDEGIYRC-------EGRV-EAR 193
SW+++ D+R F NL I + SD G Y C RV
Sbjct: 151 EIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPP 210
Query: 194 GEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEE 253
+ R+ V+ P I + F TA +G + C A G+P P I+W + I
Sbjct: 211 TPLTLRNDGVMGEYEPKIEV-HFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPS 269
Query: 254 NEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTY 313
+ L+ S L + N+ D G Y CRA N G++ + LQV+ PH ++ N+T
Sbjct: 270 KAR--LRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQL 327
Query: 314 ENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKL 372
++G + C A G+P P W + +G S R+E+ + L I +V
Sbjct: 328 DSGSPLRWECKATGKPRPTYRWLK--NGVPL-----SPQSRVEMV----NGVLMIHNVNQ 376
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDI-EYAPKFISNQ---TIYYSWEGNPINISCDVKSNP 428
SD+G Y C A ++ G S L I AP F NQ TI + + + I C + +P
Sbjct: 377 SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVT-KDQEVVIECKPQGSP 435
Query: 429 PASIHWRR-DKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
+I W++ D+ V K L S L I S +D G+Y C N G+
Sbjct: 436 KPTISWKKGDRAVRENKRIAILPDGS------LRILNASKSDEGKYVCRGENVFGSAEII 489
Query: 488 YILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHY------QVDVKEVASEI 541
L++ + K EL+ + V K + + Y +D +E
Sbjct: 490 ASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHF 549
Query: 542 WKIVRSHGVQTMVVLNNLEPNT-TYEIRVAAVNGKGQGDYSKIEIFQTLPVR-EPSPPSI 599
I +++ N L + Y RV Q + L VR P PP I
Sbjct: 550 ESIRAQASSADLMIRNILLMHAGRYGCRV-------QTTADSVSDEAELLVRGPPGPPGI 602
Query: 600 -HGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKD----KEDQWLEKKVQGNKDHIILE 654
+ + + LS + D +PI Y ++ RS + + + + + G+ + +
Sbjct: 603 VIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAV 662
Query: 655 HLQWTMGYEVQITAANRLGYSEPT 678
L + YE ++ A N +G +P+
Sbjct: 663 DLNPWVEYEFRVVATNPIGTGDPS 686
Score = 80.1 bits (196), Expect = 8e-15
Identities = 83/384 (21%), Positives = 144/384 (37%), Gaps = 47/384 (12%)
Query: 136 CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
C V +P P+ WL + E+ SD R++++ + D G Y+C G
Sbjct: 49 CEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLA-TNTVGS 107
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCR-ASGSPEPAISWFRN--GKLIE 252
I R+ + S +S + E G+ + C SPE SW N +
Sbjct: 108 ILSREATLQFAYLGNFSGRTRSAVSVRE-GQGVVLMCSPPPHSPEIIYSWVFNEFPSFVA 166
Query: 253 ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE-- 310
E+ + + L + + SD G Y+C N +V P + L+N+
Sbjct: 167 EDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTN------ARVLSPPTPLTLRNDGV 220
Query: 311 ----------------TTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI 354
T + V + C A G P+P ITW + V+G+ +
Sbjct: 221 MGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMK-VNGYIPS---------- 269
Query: 355 EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE 414
+ + + + L I +V+L D+G Y+C A + G + L + P ++
Sbjct: 270 KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDS 329
Query: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
G+P+ C P + W ++ + L ++ + +L I + +D G Y
Sbjct: 330 GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV------NGVLMIHNVNQSDAGMYQ 383
Query: 475 CTATNHIGTRFQEYIL-ALADVPS 497
C A N G + L LA P+
Sbjct: 384 CLAENKYGAIYASAELKILASAPT 407
Score = 58.9 bits (141), Expect = 2e-08
Identities = 67/290 (23%), Positives = 113/290 (38%), Gaps = 27/290 (9%)
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT 267
P + P T +++ +C G+P P+ W RNG I+ Y +
Sbjct: 25 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFI 84
Query: 268 VRNIINS-DGGPYVCRATNKAGED-EKQAFLQ-VFVQPHIIQLKNETTYENGQ-VTLVCD 323
+ N + D G Y C ATN G ++A LQ ++ + ++ + GQ V L+C
Sbjct: 85 ISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCS 144
Query: 324 AEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAA 383
PEI + + F + D R + + G +L+I V+ SD G Y C
Sbjct: 145 PPPHS-PEIIYSWVFNEFPSFVAE---DSRRFISQETG--NLYISKVQTSDVGSYICLVK 198
Query: 384 SRIGGHQ----------KSMYLDIEYAPKF-ISNQTIYYSWEGNPINISCDVKSNPPASI 432
+ + + ++ + EY PK + + +G + + C NP +I
Sbjct: 199 NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 258
Query: 433 HWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
W + +P+K + +LEI +D G Y C A N G
Sbjct: 259 TWMKVNGYIPSKARLRKS------QAVLEIPNVQLDDAGIYECRAENSRG 302
Score = 37.7 bits (86), Expect = 0.045
Identities = 31/108 (28%), Positives = 49/108 (45%), Gaps = 10/108 (9%)
Query: 491 ALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGV 550
A DV ++ V I ++ K S +P G + +++ +E +E V++ G
Sbjct: 804 APTDVKATSVSVSEILVAWKHIKESLGRPQ---GFEVGYWKDMEQEDTAET---VKTRGN 857
Query: 551 QTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPS 598
++ V+L LE NT Y V A NG G G S + + SPPS
Sbjct: 858 ESFVILTGLEGNTLYHFTVRAYNGAGYGPPSS----EVSATTKKSPPS 901
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 147 bits (370), Expect = 5e-35
Identities = 160/627 (25%), Positives = 248/627 (39%), Gaps = 75/627 (11%)
Query: 7 FYLLGLL-VSSGQALLQVTISLSKVE------LSVGESKFFTCTAIGEPE-SIDWYNPQG 58
FYL GL+ + SG L Q VE +S GE C A G P +I+WY
Sbjct: 8 FYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--- 64
Query: 59 EKIISTQRVVVQKEGVRS-------------RLTIYNANIEDAGIYRCQATDAKGQTQEA 105
+RV K+ RS R+ + D G+Y C A + G+
Sbjct: 65 ----GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 106 TVVLEI-YQKLTFREVVSPQEFKQGEDAEVVCRVSSS-PAPAVSWLYHNEEVTTISDNRF 163
LE+ + FR+ S GE A + C+ P P +SW + D R
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD-KDERI 179
Query: 164 AMLANNNLQILNINKSDEGIYRCEG-RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATA 222
+ L I KSD G Y C G + E + ++ V+ P + P N
Sbjct: 180 T-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLER-PSFVKRPS---NLAV 234
Query: 223 ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCR 282
+ F C A G P P + W ++ + ++ +Y ++ +T L +R + D G Y C
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHT-LKIRKVTAGDMGSYTCV 292
Query: 283 ATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKR-AVDG 340
A N G+ E A L V PH + + G+ VT C+A G P P I W+R
Sbjct: 293 AENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 352
Query: 341 FTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI--- 397
F+ R V + L I +V+ SD G Y C+ + G YL++
Sbjct: 353 LLFSYQPPQSSSRFSVSQ---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 409
Query: 398 --EYAPKFIS----NQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKT 451
+ P I NQT+ + +G + +SC +P +I WR+D VL + + +K
Sbjct: 410 IADRPPPVIRQGPVNQTV--AVDGTFV-LSCVATGSPVPTILWRKDG-VLVSTQDSRIKQ 465
Query: 452 YSTGRKMILEIAPTSDNDFGRYNCTATNHIGT-------RFQEYILALAD--------VP 496
G +L+I D GRY C A+ G QE+ + + +P
Sbjct: 466 LENG---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP 522
Query: 497 SSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVL 556
S+P ++ ++S+ T +S+ + G P + + W+ V + +
Sbjct: 523 SAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAI 582
Query: 557 NNLEPNTTYEIRVAAVNGKGQGDYSKI 583
L+PN Y V A N G D S+I
Sbjct: 583 KGLKPNAIYLFLVRAANAYGISDPSQI 609
Score = 130 bits (326), Expect = 7e-30
Identities = 172/758 (22%), Positives = 299/758 (39%), Gaps = 110/758 (14%)
Query: 44 AIGEPESIDWYNPQG--EKIISTQRVVVQKEGVRSRLTIYNANI-------EDAGIYRCQ 94
A+GEP ++ P+G E IS ++ + R+TI + DAG Y C
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 95 ATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEE 154
T+ G+ + L + ++ +F + S + AE C P P V W + E
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 155 VTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMP 214
+ +R+ + ++ L+I + D G Y C G+ + + + P + P
Sbjct: 263 ---LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE-NMVGKAEASATLTVQEPPHFVVKP 318
Query: 215 QKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI-------EENEKYILKGSNTELT 267
+ A G +TF C A+G+P+PAI W R G ++ +LT
Sbjct: 319 RDQVVAL---GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV-----QPHIIQLK--NETTYENGQVTL 320
+ N+ SD G Y+C+ N AG +A+L+V P +I+ N+T +G L
Sbjct: 376 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 435
Query: 321 VCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDC 380
C A G P+P I W++ DG + + D RI+ Q + L I+ KL D+GRY C
Sbjct: 436 SCVATGSPVPTILWRK--DGVLVS----TQDSRIK---QLENGVLQIRYAKLGDTGRYTC 486
Query: 381 EAASRIGGHQKSMYLDIEY------------------APKF-----ISNQTIYYSWEGNP 417
A++ G S Y++++ AP +S T+ SW+ N
Sbjct: 487 IASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL 546
Query: 418 INISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTA 477
+ + A H A+N +KT ++ K + N + A
Sbjct: 547 NSGATPTSYIIEAFSHASGSSWQTVAEN---VKTETSAIKGL------KPNAIYLFLVRA 597
Query: 478 TNHIGTRFQEYI---LALADVPSSPYGV--KIIELSQTTAKVSFNKPDSHGGVPIH-HYQ 531
N G I + DV + GV K ++ A + + P I H+
Sbjct: 598 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 657
Query: 532 VDVKEVASEIWKIV-----RSHG------------VQTMVVLNNLEPNTTYEIRVAAVNG 574
VD + + +KI+ +HG + VV+ +L YEI+
Sbjct: 658 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 717
Query: 575 KGQGDYSKIEIFQTLPVREPSPP---SIHGQPSSGKSFKLS--ITKQDDGGAPILEYIVK 629
+ QG S+I+ +TL +PP ++ +G + +S +D + EY V
Sbjct: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV- 776
Query: 630 YRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLG---YSEPTVYEFSMPP 686
+ ++ + K V G+ +++ L + Y V++ A+ G SEP +
Sbjct: 777 WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHG 836
Query: 687 KPNIIKDTLFNGLGLGAVI-------GLGVAALLLILV 717
P +D + + V+ G+G A ++++V
Sbjct: 837 NPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMV 874
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 147 bits (370), Expect = 5e-35
Identities = 116/412 (28%), Positives = 172/412 (41%), Gaps = 27/412 (6%)
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
AG Y C A ++ G + V L + + + S E+ + C S P P ++
Sbjct: 2731 AGRYTCSARNSAGVAHKH-VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTIT 2789
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNV 207
W V T + +L L+I + + D G Y C + A + ++V V
Sbjct: 2790 WQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV--QV 2845
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT 267
PP I + T G C+A GSPEP I+W ++G+ + E + EL
Sbjct: 2846 PPVIENGLPDLSTT--EGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELL 2903
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENG-QVTLVCDAEG 326
V+N+ D G Y C A N G ++ L + V P L + + G ++ L C A G
Sbjct: 2904 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARG 2963
Query: 327 EPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRI 386
P P I W V+ TEG V Q G S+L V DSG Y C A +R+
Sbjct: 2964 SPTPRIGW--TVNDRPVTEG---------VSEQDGGSTLQRAAVSREDSGTYVCWAENRV 3012
Query: 387 GGHQKSMYLDIEYAPKFISNQTIYYSWE--GNPINISCDVKSNPPASIHWRRDKLVLPAK 444
G Q ++ ++ AP + + Y E G I + C V+ +P IHW +D L L
Sbjct: 3013 GRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGS 3071
Query: 445 NTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ + + L I T +D GRY C A N +G + IL L P
Sbjct: 3072 HLRHQLQNGS-----LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP 3118
Score = 144 bits (362), Expect = 4e-34
Identities = 129/500 (25%), Positives = 210/500 (42%), Gaps = 52/500 (10%)
Query: 30 VELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V + VG+ +C PE ++ WY G+ ++ QR + G RL I A + D
Sbjct: 1851 VLVRVGDKAVLSCETDALPEPTVTWYK-DGQPLVLAQRTQALRGG--QRLEIQEAQVSDK 1907
Query: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFR----EVVSPQEFKQGEDAEVVCRVSSSPAP 144
G+Y C+ ++ G+ T L + TF E VS G + C VS PAP
Sbjct: 1908 GLYSCKVSNVAGEAVR-TFTLTVQVPPTFENPKTETVSQVA---GSPLVLTCDVSGVPAP 1963
Query: 145 AVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG---RVEARGEIDFRDI 201
V+WL V + S + LQ+ + + G Y C + EAR +D
Sbjct: 1964 TVTWLKDRMPVES-SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR-----KDF 2017
Query: 202 IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE----KY 257
+V V V P I + G+E+ C A G P P ++W ++G + ++ ++
Sbjct: 2018 VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 2077
Query: 258 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNET----TY 313
L G + L ++ + SD G Y C A N AGED + + V V P I Q + + +
Sbjct: 2078 YLDGGS--LVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSR 2135
Query: 314 ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS-SLHIKDVKL 372
VT+VC G P ++W + DG ++L HGS +L I V+L
Sbjct: 2136 PGELVTMVCPVRGSPPIHVSWLK--DGLPLPLSQRTL--------LHGSGHTLRISKVQL 2185
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDIEYAPKF--ISNQTIYYSWEGNPINISCDVKSNPPA 430
+D+G + C AAS G ++ L ++ P + Q G+ + + C+ + P
Sbjct: 2186 ADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP 2245
Query: 431 SIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYIL 490
+ W +D L + S + L++ D G Y+C A + G + + L
Sbjct: 2246 LVSWMKDG--------EPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQL 2297
Query: 491 ALADVPSSPYGVKIIELSQT 510
+ + P + ELS T
Sbjct: 2298 TVMEPPHIEDSGQPTELSLT 2317
Score = 143 bits (361), Expect = 6e-34
Identities = 117/467 (25%), Positives = 200/467 (42%), Gaps = 35/467 (7%)
Query: 42 CTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKG 100
C A G P + W+ + + S V V +G L I A + DAG YRC A++ G
Sbjct: 716 CLASGVPPPDVSWFKGH-QPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYRCVASNVAG 772
Query: 101 QTQ-EATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIS 159
T+ + + + ++T + P + C + +P+P + WL V+
Sbjct: 773 STELRYGLRVNVPPRITLPPSL-PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAG 831
Query: 160 DNRFAMLANNN-LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSF 218
+ L + + SD G Y C V A GE D +D+++ V++PP+I +
Sbjct: 832 TPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGE-DRQDVVLQVHMPPSIL--GEEL 887
Query: 219 NATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGP 278
N + E + C++ P P +SW+++G+ +E L L V D G
Sbjct: 888 NVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGH 947
Query: 279 YVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE---TTYENGQVTLVCDAEGEPIPEITWK 335
Y C A N+AG EK L V+V P + L+ T E +L C+ G P P+I+W+
Sbjct: 948 YTCEALNQAGRSEKHYNLNVWVAP-VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWR 1006
Query: 336 RAVDGFTFTEGDKSLDGRIEVKGQHGSS---SLHIKDVKLSDSGRYDCEAASRIGGHQKS 392
+ DG L QH S+ L++ +L+ G Y CE ++ +G +
Sbjct: 1007 K--DGQPLPGEGAGL--------QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 1056
Query: 393 MYLDIEYAPKFISNQ---TIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNL 449
+ L++ P+ + T + + C+ PP ++ W RD P L
Sbjct: 1057 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG--QPVGAELGL 1114
Query: 450 KTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
+ + G+ + +E A + GRY+C A N G +++ L++ P
Sbjct: 1115 QLQNQGQSLHVERAQAAHT--GRYSCVAENLAGRAERKFELSVLVPP 1159
Score = 138 bits (347), Expect = 2e-32
Identities = 123/485 (25%), Positives = 210/485 (43%), Gaps = 37/485 (7%)
Query: 12 LLVSSGQALLQVTISL-SKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVV 69
LLV + +L T L +V ++ + C A+G P +I W G + R+ V
Sbjct: 1645 LLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQ-NGLPFSPSPRLQV 1703
Query: 70 QKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEA-TVVLEIYQKLTFREVVSPQEFKQ 128
++G L + A + DA Y C A + G ++ T+ +++ ++ ++
Sbjct: 1704 LEDG--QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1761
Query: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG 188
+ C V + P P V+W Y + + ++ + F + + LQ+ SD G+Y CE
Sbjct: 1762 SS-VSLPCDVHAHPNPEVTW-YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 1819
Query: 189 RVEARGEIDFRDIIVIVNVPPAISM-PQKSFNATAER-GEEMTFSCRASGSPEPAISWFR 246
+ A G D + + + V VPPA P+ +A R G++ SC PEP ++W++
Sbjct: 1820 -LNAAGR-DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 1877
Query: 247 NGK-LIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII 305
+G+ L+ L+G L ++ SD G Y C+ +N AGE + L V V P
Sbjct: 1878 DGQPLVLAQRTQALRGGQ-RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFE 1936
Query: 306 QLKNETTYE--NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSS 363
K ET + + L CD G P P +TW + D+ +E HG
Sbjct: 1937 NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK----------DRM---PVESSAVHGVV 1983
Query: 364 S----LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNP 417
S L + ++ + +G Y C A + +K + + AP+ S+ ++ EG
Sbjct: 1984 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQE 2043
Query: 418 INISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTA 477
+ + C+ PP + W +D L +L+ Y G ++L+ S D G Y C A
Sbjct: 2044 VRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRAS--DAGAYTCVA 2101
Query: 478 TNHIG 482
N G
Sbjct: 2102 HNPAG 2106
Score = 131 bits (329), Expect = 3e-30
Identities = 128/490 (26%), Positives = 190/490 (38%), Gaps = 59/490 (12%)
Query: 35 GESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G +C G P I W G+ + + V L + A + G Y C
Sbjct: 986 GHPTSLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTC 1044
Query: 94 QATDAKGQTQEATVVLEIY---QKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLY 150
+ ++ G + + + LE++ Q RE + Q A + C + P P V+W
Sbjct: 1045 ECSNVVGNSSQ-DLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 1103
Query: 151 HNEEVTTISDNRFAMLANNNLQILNINKSDE---GIYRC-----EGRVEARGEIDFRDII 202
+ V + N Q L++ ++ G Y C GR E + E+
Sbjct: 1104 DGQPVGA----ELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELS----- 1154
Query: 203 VIVNVPPA-ISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG 261
V VPP I N TA +T C A G P PAI WFR + + E L
Sbjct: 1155 --VLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA 1212
Query: 262 SNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYE-----NG 316
L + D G Y C A+N+AGE + ++V V P I +NE E +G
Sbjct: 1213 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI---ENEDLEEVIKVLDG 1269
Query: 317 QVT-LVCDAEGEPIPEITWKRAVDGFTFTEGDK---SLDGRIEVKGQHGSSSLHIKDVKL 372
Q L+C+ G P P++TW + DG GD S DG + L + L
Sbjct: 1270 QTAHLMCNVTGHPQPKLTWFK--DGRPLARGDAHHISPDGVL----------LQVLQANL 1317
Query: 373 SDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE-----GNPINISCDVKSN 427
S +G Y C AA+ +G K L + AP + E NPI++ C+ +
Sbjct: 1318 SSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAF 1377
Query: 428 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
P +I W +D A L + G L+I D G+Y C TN +G +
Sbjct: 1378 PSPNITWMKDGAPFEASRNIQLLPGTHG----LQILNAQKEDAGQYTCVVTNELGEAVKN 1433
Query: 488 YILALADVPS 497
Y + + PS
Sbjct: 1434 YHVEVLIPPS 1443
Score = 130 bits (326), Expect = 7e-30
Identities = 120/489 (24%), Positives = 212/489 (43%), Gaps = 43/489 (8%)
Query: 30 VELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
V+ G C A G P ++ W++ +G + + ++ +G S L + + +
Sbjct: 415 VKAVAGRPVALECVARGHPSPTLSWHH-EGLPVAESNESRLETDG--SVLRLESPGEASS 471
Query: 89 GIYRCQATDAKGQTQ-EATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
G+Y C A+ G+ + +V +++ +L E + G+ E+ C+ S SP P +
Sbjct: 472 GLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 531
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN- 206
WL + ++ + A L I ++ G++ C+ EA ++ V V+
Sbjct: 532 WLQNGRPAEELAGVQVAS-QGTTLHIDHVELDHSGLFACQATNEAGTA--GAEVEVSVHG 588
Query: 207 --VPPAISMPQKSFNATAERGEEMTFSC-----RASGS-PEPAI--SWFRNGKLIEENEK 256
P + +P ++ E +C R G+ P+P + W G L E
Sbjct: 589 EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG 648
Query: 257 YILKGS-NTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ-LKNETTYE 314
+ S L + + D G Y C ATN AGE +++ L+V V P+I N+ E
Sbjct: 649 IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLE 708
Query: 315 NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEG-DKSLDGRIEVKGQHGSSSLHIKDVKLS 373
N VTL C A G P P+++W + + G S+DGR+ L I+ +LS
Sbjct: 709 NASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------LRIEQAQLS 758
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEG-----NPINISCDVKSNP 428
D+G Y C A++ G + L + P+ T+ S G P+ ++C+ P
Sbjct: 759 DAGSYRCVASNVAGSTELRYGLRVNVPPRI----TLPPSLPGPVLVNTPVRLTCNATGAP 814
Query: 429 PASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
++ W +D + T L+ + GR +L +A +D GRY+C A + +G Q+
Sbjct: 815 SPTLMWLKDGNPVSPAGTPGLQVFPGGR--VLTLASARASDSGRYSCVAVSAVGEDRQDV 872
Query: 489 ILALADVPS 497
+L + PS
Sbjct: 873 VLQVHMPPS 881
Score = 129 bits (323), Expect = 1e-29
Identities = 116/457 (25%), Positives = 185/457 (40%), Gaps = 38/457 (8%)
Query: 35 GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G TC G P ++ W + S VV + G RL + AG Y C
Sbjct: 1948 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG---RLQLSRLQPAQAGTYTC 2004
Query: 94 QATDAKGQTQEATVV-LEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHN 152
A + + + ++ VV + + ++ V +G++ + C P P V+WL
Sbjct: 2005 VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDG 2064
Query: 153 EEV-TTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAI 211
+ + + L +L + + SD G Y C A GE D R V V VPP I
Sbjct: 2065 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA-GE-DARLHTVNVLVPPTI 2122
Query: 212 SMPQKSFNATAER-GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRN 270
R GE +T C GSP +SW ++G + +++ +L GS L +
Sbjct: 2123 KQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISK 2182
Query: 271 IINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI--IQLKNETTYENGQ-VTLVCDAEGE 327
+ +D G + C A + AG ++ LQV V P + ++ +N+ G V L C+A G
Sbjct: 2183 VQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV 2242
Query: 328 PIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG 387
P+P ++W + +G+ L +E SL ++ V DSG Y C A S G
Sbjct: 2243 PLPLVSWMK--------DGEPLLSQSLE-----QGPSLQLEAVGAGDSGTYSCVAVSEAG 2289
Query: 388 GHQKSMYLDIEYAPKF--ISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN 445
++ L + P T G P+ + CD + P +I W +D L
Sbjct: 2290 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL---- 2345
Query: 446 TTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
T L+ S +++ D G Y C A + G
Sbjct: 2346 -TRLENNSRATRVL------RVRDAGLYTCLAESPAG 2375
Score = 127 bits (320), Expect = 3e-29
Identities = 113/476 (23%), Positives = 191/476 (40%), Gaps = 28/476 (5%)
Query: 28 SKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIED 87
S V E C A G P + +G + + V G +L I +A+ ED
Sbjct: 2764 SVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG---QLRIAHASPED 2820
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVS 147
AG Y C A ++ G T ++ + + +G A + C+ SP P ++
Sbjct: 2821 AGNYLCIAKNSAGSAMGKTRLV-VQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT 2879
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNV 207
W + V+ ++ +F + + L + N+ D G Y C A G R + I+ +
Sbjct: 2880 WDKDGQPVSG-AEGKFTIQPSGELLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVL 2937
Query: 208 PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELT 267
P ++P + + G+ + C A GSP P I W N + + E GS +
Sbjct: 2938 PVFTTLPG---DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRA 2994
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYE--NGQVTLVCDAE 325
+ D G YVC A N+ G + +F+ V P + E G + L C
Sbjct: 2995 A--VSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 3052
Query: 326 GEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASR 385
G+P+P+I W + +G + + Q+GS ++H + D+GRY C A +
Sbjct: 3053 GDPVPDIHWIK--------DGLPLRGSHLRHQLQNGSLTIH--RTERDDAGRYQCLAENE 3102
Query: 386 IGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN 445
+G +K + L ++ AP F G+ + + C P +I W + P +
Sbjct: 3103 MGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL--QAGQPLRA 3160
Query: 446 TTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYG 501
+ L+T G L + D G Y+C A N +G+ L + P +G
Sbjct: 3161 SRRLRTLPDGS---LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWG 3213
Score = 125 bits (313), Expect = 2e-28
Identities = 126/520 (24%), Positives = 211/520 (40%), Gaps = 72/520 (13%)
Query: 35 GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRC 93
G++ C G P+ + W+ G + + +GV L + AN+ AG Y C
Sbjct: 1269 GQTAHLMCNVTGHPQPKLTWFK-DGRPLARGDAHHISPDGVL--LQVLQANLSSAGHYSC 1325
Query: 94 QATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEV--------VCRVSSSPAPA 145
A +A G E T ++ L ++ E E+ V +C + P+P
Sbjct: 1326 IAANAVG---EKTKHFQL-SVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN 1381
Query: 146 VSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIV 205
++W+ S N + + LQILN K D G Y C E + ++ V V
Sbjct: 1382 ITWMKDGAPFEA-SRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAV--KNYHVEV 1438
Query: 206 NVPPAISMPQKSFNATAER-----GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK 260
+PP+IS + +T C + P P I W+++G+ + + + +
Sbjct: 1439 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVL 1498
Query: 261 GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP------------HIIQLK 308
G L ++ SD G Y+C ATN AGED++ + + V P I+ +
Sbjct: 1499 GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 1558
Query: 309 NE-----TTY----ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQ 359
E T Y EN L CD P P++TW R D+ L EV
Sbjct: 1559 EEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE---------DQPLSAGDEVSVL 1609
Query: 360 HGSSSLHIKDVKLSDSGRYDCEAASRIGG---HQKSMYLD----IEYAPKFISNQTIYYS 412
G L I V+ ++GRY C+A++ +G H + + L + + + T+ S
Sbjct: 1610 QGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 1669
Query: 413 WEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGR 472
+ +++ C NP +I W ++ LP + L+ G+ +L+++ D
Sbjct: 1670 ---STVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQ--VLQVSTAEVADAAS 1722
Query: 473 YNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTA 512
Y C A N G+ + + L + VP G ++L Q TA
Sbjct: 1723 YMCVAENQAGSAEKLFTLRV-QVPPRIAG---LDLEQVTA 1758
Score = 119 bits (299), Expect = 9e-27
Identities = 94/361 (26%), Positives = 148/361 (40%), Gaps = 21/361 (5%)
Query: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG 188
G D E+ C S P P V W + V + L+I + DEG Y+C
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291
Query: 189 RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNG 248
A + RD + V+ PP I ++ + C A G P P I+WF++G
Sbjct: 292 FSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 349
Query: 249 KLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLK 308
L+ + K + +L + +SD G Y C+A+N G EK L V+V P I
Sbjct: 350 ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAG 409
Query: 309 NE----TTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSS 364
V L C A G P P ++W +G E ++S R+E G S
Sbjct: 410 GRPYVVKAVAGRPVALECVARGHPSPTLSWHH--EGLPVAESNES---RLETDG----SV 460
Query: 365 LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISC 422
L ++ + SG Y C A+S G ++++ P+ + + + + G P+ + C
Sbjct: 461 LRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 520
Query: 423 DVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
+P +I W ++ PA+ ++ S G L I + G + C ATN G
Sbjct: 521 QASGSPVPTIQWLQNG--RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAG 576
Query: 483 T 483
T
Sbjct: 577 T 577
Score = 119 bits (298), Expect = 1e-26
Identities = 127/498 (25%), Positives = 192/498 (38%), Gaps = 41/498 (8%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLT 79
L V L +V VG+ C A G P +I W G V V +G + L
Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQ-NGRPAEELAGVQVASQG--TTLH 555
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSP-QEFKQGEDAEVVCRV 138
I + ++ +G++ CQAT+ G T A V + ++ + + P ++ G +
Sbjct: 556 IDHVELDHSGLFACQATNEAG-TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPA 614
Query: 139 SSSPAPAVSWLYHNE---------------EVTTISDNRFAMLANNNLQILNINKSDEGI 183
+ P W H + E T I A LQI ++ DEGI
Sbjct: 615 ACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP---VAYSLPPPLQIEKVDLRDEGI 671
Query: 184 YRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS 243
Y C GE R++ + V VPP I N +T C ASG P P +S
Sbjct: 672 YTCAA-TNLAGESK-REVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVS 727
Query: 244 WFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPH 303
WF+ + + + L + SD G Y C A+N AG E + L+V V P
Sbjct: 728 WFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPR 787
Query: 304 IIQLKN--ETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHG 361
I + N V L C+A G P P + W + DG S G ++ G
Sbjct: 788 ITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK--DG-----NPVSPAGTPGLQVFPG 840
Query: 362 SSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINIS 421
L + + SDSGRY C A S +G ++ + L + P + + + +
Sbjct: 841 GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALE 900
Query: 422 CDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHI 481
C + PP + W +D L + +L + K +L++ D G Y C A N
Sbjct: 901 CQSHAMPPPVLSWWKDGRPLEPRPGVHL----SADKALLQVDRADVWDAGHYTCEALNQA 956
Query: 482 GTRFQEYILALADVPSSP 499
G + Y L + P P
Sbjct: 957 GRSEKHYNLNVWVAPVFP 974
Score = 112 bits (280), Expect = 1e-24
Identities = 119/496 (23%), Positives = 194/496 (39%), Gaps = 47/496 (9%)
Query: 42 CTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKG 100
C G P ++W + + + VQ++G R+T +++ D G Y+C A G
Sbjct: 239 CWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT--GSHVGDEGRYQCVAFSPAG 296
Query: 101 QTQEATVVLEIYQKLTFREVVSPQEFKQGED--AEVVCRVSSSPAPAVSWLYHNEEVTTI 158
Q Q L ++ T E ED +++C P P ++W + + +
Sbjct: 297 Q-QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW-FKDGALLPT 354
Query: 159 SDNRFAMLANNNLQILNINKSDEGIYRCE-----GRVEARGEIDFRDIIVIVNVPPAI-S 212
S LQ+ SD G+Y C+ G E +D V VPP I
Sbjct: 355 STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLD-------VYVPPTIEG 407
Query: 213 MPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNII 272
+ + A G + C A G P P +SW G + E+ + L+ + L + +
Sbjct: 408 AGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPG 467
Query: 273 NSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII---QLKNETTYENGQVTLVCDAEGEPI 329
+ G Y C A++ AGE Q ++V V P ++ L TT + L C A G P+
Sbjct: 468 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPV 527
Query: 330 PEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG-- 387
P I W + + + V+ ++LHI V+L SG + C+A + G
Sbjct: 528 PTIQW---------LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA 578
Query: 388 GHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHW---RRDKLVLPAK 444
G + + + E+AP + Y W G + S +PP W + LV
Sbjct: 579 GAEVEVSVHGEWAPGVLEVPIGQYHW-GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 637
Query: 445 NTTNLKTYSTGRKMI------LEIAPTSDNDFGRYNCTATNHIGTRFQEY---ILALADV 495
+ +L TG + L+I D G Y C ATN G +E +L ++
Sbjct: 638 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNI 697
Query: 496 PSSPYGVKIIELSQTT 511
P ++E + T
Sbjct: 698 EPGPVNKAVLENASVT 713
Score = 110 bits (276), Expect = 4e-24
Identities = 115/513 (22%), Positives = 201/513 (39%), Gaps = 54/513 (10%)
Query: 28 SKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIED 87
+++ L+ G C A G P+ ++ G+ + + SR T + D
Sbjct: 2312 TELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLEN--------NSRATRV-LRVRD 2362
Query: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQ--EFKQG---EDAEVVCRVSSSP 142
AG+Y C A G +++ V + +V P+ F G + C V + P
Sbjct: 2363 AGLYTCLAESPAGAIEKSFRV----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP 2418
Query: 143 APAVSWLYHNEEVTTISDNRFAMLANNN-LQILNINKSDEGIYRCEGRVEARG-----EI 196
AP ++W H + + D LQ+ ++ +D G Y C R A +
Sbjct: 2419 APKITW--HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 2476
Query: 197 DFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEK 256
+ + I + PPA+++ S N TA C+A G P P +SW ++ ++
Sbjct: 2477 EIHTVPTIRSGPPAVNV---SVNQTA------LLPCQADGVPAPLVSWRKDRVPLDPRSP 2527
Query: 257 YILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQL-KNETTYEN 315
L ++ ++ D G Y+C A+N AG D + L+V P I N T +
Sbjct: 2528 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587
Query: 316 GQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH--GSSSLHIKDVKLS 373
L C+A G P P + W + +G K LD R++ S++L +
Sbjct: 2588 TPALLPCEASGSPKPLVVW--------WKDGQK-LDFRLQQGAYRLLPSNALLLTAPGPQ 2638
Query: 374 DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIH 433
DS +++C ++ +G + + + P +QT + P+ ++C P ++
Sbjct: 2639 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2698
Query: 434 WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALA 493
W + L A+ + Y LEI GRY C+A N G + L
Sbjct: 2699 WSKAGAQLGARGS----GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLT-- 2752
Query: 494 DVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVP 526
V +SP + + + A+ P G+P
Sbjct: 2753 -VQASPVVKPLPSVVRAVAEEEVLLPCEASGIP 2784
Score = 99.0 bits (245), Expect = 2e-20
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 31/450 (6%)
Query: 42 CTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQ 101
C A G P + + GE ++S ++G +L A D+G Y C A G+
Sbjct: 2237 CEARGVPLPLVSWMKDGEPLLSQSL----EQGPSLQLEAVGAG--DSGTYSCVAVSEAGE 2290
Query: 102 TQEATVVLEIYQKLTFREVVSPQEFK--QGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIS 159
+ L + + + P E G E++C +P P ++W + +T +
Sbjct: 2291 ARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLE 2349
Query: 160 DNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFN 219
+N A ++L + D G+Y C A G I+ + V V PP I P+
Sbjct: 2350 NNSRAT------RVLRVR--DAGLYTCLAESPA-GAIE-KSFRVRVQAPPNIVGPRGPRF 2399
Query: 220 ATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPY 279
++ C P P I+W R+G +++E+ L ++ + +D G Y
Sbjct: 2400 VVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDY 2459
Query: 280 VCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLV-CDAEGEPIPEITWKRAV 338
C A N AG +++ P I Q L+ C A+G P P ++W++
Sbjct: 2460 SCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK-- 2517
Query: 339 DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
LD R SL I+ V D+G Y C A++ G ++ L +
Sbjct: 2518 -------DRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2570
Query: 399 YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKM 458
P + + P + C+ +P + W +D L + +
Sbjct: 2571 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 2630
Query: 459 ILEIAPTSDNDFGRYNCTATNHIGTRFQEY 488
+L AP D ++ C +N +G + Y
Sbjct: 2631 LL-TAP-GPQDSAQFECVVSNEVGEAHRLY 2658
Score = 94.7 bits (234), Expect = 3e-19
Identities = 114/501 (22%), Positives = 192/501 (38%), Gaps = 60/501 (11%)
Query: 27 LSKVELSVGESKFFTCTAIGEPE-SIDWYN-PQGEKIISTQRVVVQKEGVRSRLTIYNAN 84
L V L+VG + C G P+ + W P E + V V +EG L + + +
Sbjct: 10 LGDVALTVG-LEAGGCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG---SLFLASVS 65
Query: 85 IEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK--QGEDAEVVCRVSSSP 142
D+G Y CQAT+ G T L +Y + RE G+ + C + P
Sbjct: 66 PADSGDYECQATNEVGSTSR-RAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFP 124
Query: 143 APAVSWLYHNEEVTT---------------ISDNRFAMLANNNLQILNINKSDEGIYRCE 187
P + WL + V + +R + +L I G +
Sbjct: 125 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL-LDEGQSLHFPRIQPGRSGRRGAQ 183
Query: 188 GRVEARGEIDFRDIIVIVN---VPPAISMPQKSFNATAERGEE--------MTFSCRASG 236
A+ + + + P A S P A +E + C SG
Sbjct: 184 AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSG 243
Query: 237 SPEPAISWFRNGKLIEENEKYI-LKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
P P + W ++ + + ++ ++ L + D G Y C A + AG+ +
Sbjct: 244 VPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQ 303
Query: 296 LQVFVQPHIIQLKNET----TYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLD 351
L+V P I NET E+ V L+C+A G P P ITW + DG K +
Sbjct: 304 LRVHAPP-TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK--DGALLPTSTKVVY 360
Query: 352 GRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFI----SNQ 407
R G L + + SD+G Y C+A++ +G +K+ LD+ Y P I
Sbjct: 361 TR-------GGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVPPTIEGAGGRP 412
Query: 408 TIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSD 467
+ + G P+ + C + +P ++ W + L + N + L+T + +L + +
Sbjct: 413 YVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS----VLRLESPGE 468
Query: 468 NDFGRYNCTATNHIGTRFQEY 488
G Y+C A++ G +Y
Sbjct: 469 ASSGLYSCVASSPAGEAVLQY 489
Score = 89.4 bits (220), Expect = 1e-17
Identities = 93/415 (22%), Positives = 152/415 (36%), Gaps = 65/415 (15%)
Query: 136 CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
C +P P V+W A+L +L + +++ +D G Y C+ E
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNG------- 248
R ++V VPP+I + N + G+ +T C A+G P P I W ++
Sbjct: 84 S--RRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPL 141
Query: 249 -----------------KLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDE 291
+L++E + + R + G A KA
Sbjct: 142 GWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGS-----AQTKAPWXA 196
Query: 292 KQAFLQVFVQPHIIQ------------LKNETTYENGQVTLVCDAEGEPIPEITWKRAVD 339
A + F PH + V L C G P P++ W +
Sbjct: 197 GLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK--- 253
Query: 340 GFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEY 399
+ L G ++ Q L I + D GRY C A S G + L + +
Sbjct: 254 -----DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV-H 307
Query: 400 APKFI--SNQTIYYS-WEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGR 456
AP I SN+T + E + + + C+ + P +I W +D +LP T+ Y+ G
Sbjct: 308 APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLP---TSTKVVYTRGG 364
Query: 457 KMILEIAPTSDNDFGRYNCTATNHIG-----TRFQEYI-LALADVPSSPYGVKII 505
+ L++ +D G Y C A+N +G TR Y+ + PY VK +
Sbjct: 365 RQ-LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV 418
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 145 bits (366), Expect = 2e-34
Identities = 112/425 (26%), Positives = 182/425 (42%), Gaps = 50/425 (11%)
Query: 96 TDAKGQTQEATVVLEIYQKLTFREV--VSPQEFK--------QGEDAEVV--------CR 137
T A+ +A + E +++ R V ++P+E + +DA+V CR
Sbjct: 209 TYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCR 268
Query: 138 VSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEID 197
+P P + WL +N E++ +D+R +L + L I N ++D+GIY+C + GE+
Sbjct: 269 AEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAK-NVAGEVK 327
Query: 198 FRDIIVIVNVPPA----ISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEE 253
+++ + PA + PQ N GE +T C A+G P P ISW R +
Sbjct: 328 TQEVTLRYFGSPARPTFVIQPQ---NTEVLVGESVTLECSATGHPPPRISWTRGDRTPLP 384
Query: 254 NEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTY 313
+ + + L ++N++ D G Y C ATN AF+ V P +
Sbjct: 385 VDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVV 444
Query: 314 ENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH---GSSSLHIKD 369
GQ V C+A+G P P I W T+G L V +H S +L I
Sbjct: 445 IEGQTVDFQCEAKGNPPPVIAW---------TKGGSQL----SVDRRHLVLSSGTLRISG 491
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDIE--YAPKFISNQTIYYSWEGNPINISCDVKSN 427
V L D G+Y+C+A + IG + +L ++ P F S + G + + C +
Sbjct: 492 VALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGE 551
Query: 428 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
P +I W +D + T + + L I D GRY C A N IG+
Sbjct: 552 PEPAITWNKDGV-----QVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVS 606
Query: 488 YILAL 492
+L++
Sbjct: 607 MVLSV 611
Score = 144 bits (362), Expect = 4e-34
Identities = 111/386 (28%), Positives = 172/386 (44%), Gaps = 31/386 (8%)
Query: 22 QVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQ-RVVVQKEGVRSRLT 79
++T +++ G + +FTC A G P+ I W E + T R+ + +G L
Sbjct: 247 RITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT---LM 303
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIY---QKLTFREVVSPQ--EFKQGEDAEV 134
I N D GIY+C A + G+ + V L + + TF V+ PQ E GE +
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF--VIQPQNTEVLVGESVTL 361
Query: 135 VCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARG 194
C + P P +SW + D R + + L I N+ + D G Y C
Sbjct: 362 ECSATGHPPPRISWT-RGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSA-TNNID 419
Query: 195 EIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEEN 254
+ I++ +P PQ + G+ + F C A G+P P I+W + G + +
Sbjct: 420 SVHATAFIIVQALPQFTVTPQ---DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD 476
Query: 255 EKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFL--QVFVQPHIIQLKNETT 312
++++ S T L + + D G Y C+A N G + A L Q V P + ++TT
Sbjct: 477 RRHLVLSSGT-LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
Query: 313 YENG-QVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVK 371
E G V L C ++GEP P ITW + DG TE G+ + + L I DV
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITWNK--DGVQVTE-----SGKFHISPE---GFLTINDVG 585
Query: 372 LSDSGRYDCEAASRIGGHQKSMYLDI 397
+D+GRY+C A + IG SM L +
Sbjct: 586 PADAGRYECVARNTIGSASVSMVLSV 611
Score = 92.8 bits (229), Expect = 1e-18
Identities = 74/282 (26%), Positives = 123/282 (43%), Gaps = 20/282 (7%)
Query: 25 ISLSKVELSVGESKFFTCTAIGEPES-IDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNA 83
I E+ VGES C+A G P I W + RV + G L I N
Sbjct: 346 IQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSG---GLYIQNV 402
Query: 84 NIEDAGIYRCQATDAKGQTQE-ATVVLEIYQKLTFREVVSPQE--FKQGEDAEVVCRVSS 140
D+G Y C AT+ A ++++ + T V+PQ+ +G+ + C
Sbjct: 403 VQGDSGEYACSATNNIDSVHATAFIIVQALPQFT----VTPQDRVVIEGQTVDFQCEAKG 458
Query: 141 SPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRD 200
+P P ++W +++ D R +L++ L+I + D+G Y C+ A I +
Sbjct: 459 NPPPVIAWTKGGSQLSV--DRRHLVLSSGTLRISGVALHDQGQYECQ----AVNIIGSQK 512
Query: 201 IIVIVNVPPAISMPQKSF--NATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYI 258
++ + V P ++ S + T E G + C + G PEPAI+W ++G + E+ K+
Sbjct: 513 VVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFH 572
Query: 259 LKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV 300
+ LT+ ++ +D G Y C A N G L V V
Sbjct: 573 ISPEGF-LTINDVGPADAGRYECVARNTIGSASVSMVLSVNV 613
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 13/208 (6%)
Query: 18 QALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSR 77
QAL Q T++ + G++ F C A G P + + G ++ +R +V G
Sbjct: 430 QALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT--- 486
Query: 78 LTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLT--FREVVSPQEFKQGEDAEVV 135
L I + D G Y CQA + G +Q+ L + ++T F + S + G + ++
Sbjct: 487 LRISGVALHDQGQYECQAVNIIG-SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLP 545
Query: 136 CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
C P PA++W + + V +F + L I ++ +D G Y C AR
Sbjct: 546 CSSQGEPEPAITW--NKDGVQVTESGKFHISPEGFLTINDVGPADAGRYEC----VARNT 599
Query: 196 IDFRDIIVIVNV-PPAISMPQKSFNATA 222
I + ++++V P +S F AT+
Sbjct: 600 IGSASVSMVLSVNVPDVSRNGDPFVATS 627
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 144 bits (362), Expect = 4e-34
Identities = 161/630 (25%), Positives = 249/630 (39%), Gaps = 78/630 (12%)
Query: 7 FYLLGLL-VSSGQALLQVTISLSKVE------LSVGESKFFTCTAIGEPE-SIDWYNPQG 58
FYL GL+ + SG L Q VE +S GE C A G P +I+WY
Sbjct: 8 FYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--- 64
Query: 59 EKIISTQRVVVQKEGVRS-------------RLTIYNANIEDAGIYRCQATDAKGQTQEA 105
+RV K+ RS R+ + D G+Y C A + G+
Sbjct: 65 ----GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 106 TVVLEI-YQKLTFREVVSPQEFKQGEDAEVVCRVSSS-PAPAVSWLYHNEEVTTISDNRF 163
LE+ + FR+ S GE A + C+ P P +SW + D R
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD-KDERI 179
Query: 164 AMLANNNLQILNINKSDEGIYRCEG-RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATA 222
+ L I KSD G Y C G + E + ++ V+ P + P N
Sbjct: 180 T-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLER-PSFVKRPS---NLAV 234
Query: 223 ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCR 282
+ F C A G P P + W ++ + ++ +Y ++ +T L +R + D G Y C
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHT-LKIRKVTAGDMGSYTCV 292
Query: 283 ATNKAGEDEKQAFLQVFV---QPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKR-A 337
A N G+ E A L V V PH + + G+ VT C+A G P P I W+R
Sbjct: 293 AENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 338 VDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI 397
F+ R V + L I +V+ SD G Y C+ + G YL++
Sbjct: 353 SQNLLFSYQPPQSSSRFSVSQ---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Query: 398 -----EYAPKFIS----NQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTN 448
+ P I NQT+ + +G + +SC +P +I WR+D VL + +
Sbjct: 410 TDVIADRPPPVIRQGPVNQTV--AVDGTFV-LSCVATGSPVPTILWRKDG-VLVSTQDSR 465
Query: 449 LKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT-------RFQEYILALAD------- 494
+K G +L+I D GRY C A+ G QE+ + +
Sbjct: 466 IKQLENG---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 522
Query: 495 -VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
+PS+P ++ ++S+ T +S+ + G P + + W+ V +
Sbjct: 523 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET 582
Query: 554 VVLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
+ L+PN Y V A N G D S+I
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQI 612
Score = 129 bits (325), Expect = 9e-30
Identities = 172/759 (22%), Positives = 300/759 (39%), Gaps = 109/759 (14%)
Query: 44 AIGEPESIDWYNPQG--EKIISTQRVVVQKEGVRSRLTIYNANI-------EDAGIYRCQ 94
A+GEP ++ P+G E IS ++ + R+TI + DAG Y C
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 95 ATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEE 154
T+ G+ + L + ++ +F + S + AE C P P V W + E
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 155 VTTISDNRFAMLANNNLQILNINKSDEGIYRCEGR-VEARGEIDFRDIIVIVNVPPAISM 213
+ +R+ + ++ L+I + D G Y C + + E + + + PP +
Sbjct: 263 ---LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 214 PQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI-------EENEKYILKGSNTEL 266
K + G +TF C A+G+P+PAI W R G ++ +L
Sbjct: 320 --KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 267 TVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV-----QPHIIQLK--NETTYENGQVT 319
T+ N+ SD G Y+C+ N AG +A+L+V P +I+ N+T +G
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYD 379
L C A G P+P I W++ DG + + D RI+ Q + L I+ KL D+GRY
Sbjct: 438 LSCVATGSPVPTILWRK--DGVLVS----TQDSRIK---QLENGVLQIRYAKLGDTGRYT 488
Query: 380 CEAASRIGGHQKSMYLDIEY------------------APKF-----ISNQTIYYSWEGN 416
C A++ G S Y++++ AP +S T+ SW+ N
Sbjct: 489 CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
Query: 417 PINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCT 476
+ + A H A+N +KT ++ K + N +
Sbjct: 549 LNSGATPTSYIIEAFSHASGSSWQTVAEN---VKTETSAIKGL------KPNAIYLFLVR 599
Query: 477 ATNHIGTRFQEYI---LALADVPSSPYGV--KIIELSQTTAKVSFNKPDSHGGVPIH-HY 530
A N G I + DV + GV K ++ A + + P I H+
Sbjct: 600 AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW 659
Query: 531 QVDVKEVASEIWKIV-----RSHG------------VQTMVVLNNLEPNTTYEIRVAAVN 573
VD + + +KI+ +HG + VV+ +L YEI+
Sbjct: 660 TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 574 GKGQGDYSKIEIFQTLPVREPSPP---SIHGQPSSGKSFKLS--ITKQDDGGAPILEYIV 628
+ QG S+I+ +TL +PP ++ +G + +S +D + EY V
Sbjct: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
Query: 629 KYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLG---YSEPTVYEFSMP 685
+ ++ + K V G+ +++ L + Y V++ A+ G SEP +
Sbjct: 780 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAH 838
Query: 686 PKPNIIKDTLFNGLGLGAVI-------GLGVAALLLILV 717
P +D + + V+ G+G A ++++V
Sbjct: 839 GNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMV 877
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 144 bits (362), Expect = 4e-34
Identities = 161/630 (25%), Positives = 249/630 (39%), Gaps = 78/630 (12%)
Query: 7 FYLLGLL-VSSGQALLQVTISLSKVE------LSVGESKFFTCTAIGEPE-SIDWYNPQG 58
FYL GL+ + SG L Q VE +S GE C A G P +I+WY
Sbjct: 8 FYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--- 64
Query: 59 EKIISTQRVVVQKEGVRS-------------RLTIYNANIEDAGIYRCQATDAKGQTQEA 105
+RV K+ RS R+ + D G+Y C A + G+
Sbjct: 65 ----GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 106 TVVLEI-YQKLTFREVVSPQEFKQGEDAEVVCRVSSS-PAPAVSWLYHNEEVTTISDNRF 163
LE+ + FR+ S GE A + C+ P P +SW + D R
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD-KDERI 179
Query: 164 AMLANNNLQILNINKSDEGIYRCEG-RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATA 222
+ L I KSD G Y C G + E + ++ V+ P + P N
Sbjct: 180 T-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLER-PSFVKRPS---NLAV 234
Query: 223 ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCR 282
+ F C A G P P + W ++ + ++ +Y ++ +T L +R + D G Y C
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHT-LKIRKVTAGDMGSYTCV 292
Query: 283 ATNKAGEDEKQAFLQVFV---QPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKR-A 337
A N G+ E A L V V PH + + G+ VT C+A G P P I W+R
Sbjct: 293 AENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 338 VDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI 397
F+ R V + L I +V+ SD G Y C+ + G YL++
Sbjct: 353 SQNLLFSYQPPQSSSRFSVSQ---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Query: 398 -----EYAPKFIS----NQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTN 448
+ P I NQT+ + +G + +SC +P +I WR+D VL + +
Sbjct: 410 TDVIADRPPPVIRQGPVNQTV--AVDGTFV-LSCVATGSPVPTILWRKDG-VLVSTQDSR 465
Query: 449 LKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT-------RFQEYILALAD------- 494
+K G +L+I D GRY C A+ G QE+ + +
Sbjct: 466 IKQLENG---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 522
Query: 495 -VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
+PS+P ++ ++S+ T +S+ + G P + + W+ V +
Sbjct: 523 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET 582
Query: 554 VVLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
+ L+PN Y V A N G D S+I
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQI 612
Score = 129 bits (325), Expect = 9e-30
Identities = 172/759 (22%), Positives = 300/759 (39%), Gaps = 109/759 (14%)
Query: 44 AIGEPESIDWYNPQG--EKIISTQRVVVQKEGVRSRLTIYNANI-------EDAGIYRCQ 94
A+GEP ++ P+G E IS ++ + R+TI + DAG Y C
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 95 ATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEE 154
T+ G+ + L + ++ +F + S + AE C P P V W + E
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 155 VTTISDNRFAMLANNNLQILNINKSDEGIYRCEGR-VEARGEIDFRDIIVIVNVPPAISM 213
+ +R+ + ++ L+I + D G Y C + + E + + + PP +
Sbjct: 263 ---LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 214 PQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI-------EENEKYILKGSNTEL 266
K + G +TF C A+G+P+PAI W R G ++ +L
Sbjct: 320 --KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 267 TVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV-----QPHIIQLK--NETTYENGQVT 319
T+ N+ SD G Y+C+ N AG +A+L+V P +I+ N+T +G
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYD 379
L C A G P+P I W++ DG + + D RI+ Q + L I+ KL D+GRY
Sbjct: 438 LSCVATGSPVPTILWRK--DGVLVS----TQDSRIK---QLENGVLQIRYAKLGDTGRYT 488
Query: 380 CEAASRIGGHQKSMYLDIEY------------------APKF-----ISNQTIYYSWEGN 416
C A++ G S Y++++ AP +S T+ SW+ N
Sbjct: 489 CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
Query: 417 PINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCT 476
+ + A H A+N +KT ++ K + N +
Sbjct: 549 LNSGATPTSYIIEAFSHASGSSWQTVAEN---VKTETSAIKGL------KPNAIYLFLVR 599
Query: 477 ATNHIGTRFQEYI---LALADVPSSPYGV--KIIELSQTTAKVSFNKPDSHGGVPIH-HY 530
A N G I + DV + GV K ++ A + + P I H+
Sbjct: 600 AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW 659
Query: 531 QVDVKEVASEIWKIV-----RSHG------------VQTMVVLNNLEPNTTYEIRVAAVN 573
VD + + +KI+ +HG + VV+ +L YEI+
Sbjct: 660 TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 574 GKGQGDYSKIEIFQTLPVREPSPP---SIHGQPSSGKSFKLS--ITKQDDGGAPILEYIV 628
+ QG S+I+ +TL +PP ++ +G + +S +D + EY V
Sbjct: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
Query: 629 KYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLG---YSEPTVYEFSMP 685
+ ++ + K V G+ +++ L + Y V++ A+ G SEP +
Sbjct: 780 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAH 838
Query: 686 PKPNIIKDTLFNGLGLGAVI-------GLGVAALLLILV 717
P +D + + V+ G+G A ++++V
Sbjct: 839 GNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMV 877
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 144 bits (362), Expect = 4e-34
Identities = 161/630 (25%), Positives = 249/630 (39%), Gaps = 78/630 (12%)
Query: 7 FYLLGLL-VSSGQALLQVTISLSKVE------LSVGESKFFTCTAIGEPE-SIDWYNPQG 58
FYL GL+ + SG L Q VE +S GE C A G P +I+WY
Sbjct: 8 FYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--- 64
Query: 59 EKIISTQRVVVQKEGVRS-------------RLTIYNANIEDAGIYRCQATDAKGQTQEA 105
+RV K+ RS R+ + D G+Y C A + G+
Sbjct: 65 ----GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 106 TVVLEI-YQKLTFREVVSPQEFKQGEDAEVVCRVSSS-PAPAVSWLYHNEEVTTISDNRF 163
LE+ + FR+ S GE A + C+ P P +SW + D R
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD-KDERI 179
Query: 164 AMLANNNLQILNINKSDEGIYRCEG-RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATA 222
+ L I KSD G Y C G + E + ++ V+ P + P N
Sbjct: 180 T-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLER-PSFVKRPS---NLAV 234
Query: 223 ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCR 282
+ F C A G P P + W ++ + ++ +Y ++ +T L +R + D G Y C
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHT-LKIRKVTAGDMGSYTCV 292
Query: 283 ATNKAGEDEKQAFLQVFV---QPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKR-A 337
A N G+ E A L V V PH + + G+ VT C+A G P P I W+R
Sbjct: 293 AENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 338 VDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI 397
F+ R V + L I +V+ SD G Y C+ + G YL++
Sbjct: 353 SQNLLFSYQPPQSSSRFSVSQ---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Query: 398 -----EYAPKFIS----NQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTN 448
+ P I NQT+ + +G + +SC +P +I WR+D VL + +
Sbjct: 410 TDVIADRPPPVIRQGPVNQTV--AVDGTFV-LSCVATGSPVPTILWRKDG-VLVSTQDSR 465
Query: 449 LKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT-------RFQEYILALAD------- 494
+K G +L+I D GRY C A+ G QE+ + +
Sbjct: 466 IKQLENG---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 522
Query: 495 -VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
+PS+P ++ ++S+ T +S+ + G P + + W+ V +
Sbjct: 523 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET 582
Query: 554 VVLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
+ L+PN Y V A N G D S+I
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQI 612
Score = 129 bits (325), Expect = 9e-30
Identities = 172/759 (22%), Positives = 300/759 (39%), Gaps = 109/759 (14%)
Query: 44 AIGEPESIDWYNPQG--EKIISTQRVVVQKEGVRSRLTIYNANI-------EDAGIYRCQ 94
A+GEP ++ P+G E IS ++ + R+TI + DAG Y C
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 95 ATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEE 154
T+ G+ + L + ++ +F + S + AE C P P V W + E
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 155 VTTISDNRFAMLANNNLQILNINKSDEGIYRCEGR-VEARGEIDFRDIIVIVNVPPAISM 213
+ +R+ + ++ L+I + D G Y C + + E + + + PP +
Sbjct: 263 ---LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 214 PQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI-------EENEKYILKGSNTEL 266
K + G +TF C A+G+P+PAI W R G ++ +L
Sbjct: 320 --KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 267 TVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV-----QPHIIQLK--NETTYENGQVT 319
T+ N+ SD G Y+C+ N AG +A+L+V P +I+ N+T +G
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYD 379
L C A G P+P I W++ DG + + D RI+ Q + L I+ KL D+GRY
Sbjct: 438 LSCVATGSPVPTILWRK--DGVLVS----TQDSRIK---QLENGVLQIRYAKLGDTGRYT 488
Query: 380 CEAASRIGGHQKSMYLDIEY------------------APKF-----ISNQTIYYSWEGN 416
C A++ G S Y++++ AP +S T+ SW+ N
Sbjct: 489 CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
Query: 417 PINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCT 476
+ + A H A+N +KT ++ K + N +
Sbjct: 549 LNSGATPTSYIIEAFSHASGSSWQTVAEN---VKTETSAIKGL------KPNAIYLFLVR 599
Query: 477 ATNHIGTRFQEYI---LALADVPSSPYGV--KIIELSQTTAKVSFNKPDSHGGVPIH-HY 530
A N G I + DV + GV K ++ A + + P I H+
Sbjct: 600 AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW 659
Query: 531 QVDVKEVASEIWKIV-----RSHG------------VQTMVVLNNLEPNTTYEIRVAAVN 573
VD + + +KI+ +HG + VV+ +L YEI+
Sbjct: 660 TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 574 GKGQGDYSKIEIFQTLPVREPSPP---SIHGQPSSGKSFKLS--ITKQDDGGAPILEYIV 628
+ QG S+I+ +TL +PP ++ +G + +S +D + EY V
Sbjct: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
Query: 629 KYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLG---YSEPTVYEFSMP 685
+ ++ + K V G+ +++ L + Y V++ A+ G SEP +
Sbjct: 780 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAH 838
Query: 686 PKPNIIKDTLFNGLGLGAVI-------GLGVAALLLILV 717
P +D + + V+ G+G A ++++V
Sbjct: 839 GNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMV 877
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 144 bits (362), Expect = 4e-34
Identities = 161/630 (25%), Positives = 249/630 (39%), Gaps = 78/630 (12%)
Query: 7 FYLLGLL-VSSGQALLQVTISLSKVE------LSVGESKFFTCTAIGEPE-SIDWYNPQG 58
FYL GL+ + SG L Q VE +S GE C A G P +I+WY
Sbjct: 8 FYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--- 64
Query: 59 EKIISTQRVVVQKEGVRS-------------RLTIYNANIEDAGIYRCQATDAKGQTQEA 105
+RV K+ RS R+ + D G+Y C A + G+
Sbjct: 65 ----GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 106 TVVLEI-YQKLTFREVVSPQEFKQGEDAEVVCRVSSS-PAPAVSWLYHNEEVTTISDNRF 163
LE+ + FR+ S GE A + C+ P P +SW + D R
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD-KDERI 179
Query: 164 AMLANNNLQILNINKSDEGIYRCEG-RVEARGEIDFRDIIVIVNVPPAISMPQKSFNATA 222
+ L I KSD G Y C G + E + ++ V+ P + P N
Sbjct: 180 T-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLER-PSFVKRPS---NLAV 234
Query: 223 ERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCR 282
+ F C A G P P + W ++ + ++ +Y ++ +T L +R + D G Y C
Sbjct: 235 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHT-LKIRKVTAGDMGSYTCV 292
Query: 283 ATNKAGEDEKQAFLQVFV---QPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKR-A 337
A N G+ E A L V V PH + + G+ VT C+A G P P I W+R
Sbjct: 293 AENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 338 VDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI 397
F+ R V + L I +V+ SD G Y C+ + G YL++
Sbjct: 353 SQNLLFSYQPPQSSSRFSVSQ---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Query: 398 -----EYAPKFIS----NQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTN 448
+ P I NQT+ + +G + +SC +P +I WR+D VL + +
Sbjct: 410 TDVIADRPPPVIRQGPVNQTV--AVDGTFV-LSCVATGSPVPTILWRKDG-VLVSTQDSR 465
Query: 449 LKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT-------RFQEYILALAD------- 494
+K G +L+I D GRY C A+ G QE+ + +
Sbjct: 466 IKQLENG---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 522
Query: 495 -VPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM 553
+PS+P ++ ++S+ T +S+ + G P + + W+ V +
Sbjct: 523 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET 582
Query: 554 VVLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
+ L+PN Y V A N G D S+I
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQI 612
Score = 129 bits (325), Expect = 9e-30
Identities = 172/759 (22%), Positives = 300/759 (39%), Gaps = 109/759 (14%)
Query: 44 AIGEPESIDWYNPQG--EKIISTQRVVVQKEGVRSRLTIYNANI-------EDAGIYRCQ 94
A+GEP ++ P+G E IS ++ + R+TI + DAG Y C
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 95 ATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEE 154
T+ G+ + L + ++ +F + S + AE C P P V W + E
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 155 VTTISDNRFAMLANNNLQILNINKSDEGIYRCEGR-VEARGEIDFRDIIVIVNVPPAISM 213
+ +R+ + ++ L+I + D G Y C + + E + + + PP +
Sbjct: 263 ---LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 214 PQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI-------EENEKYILKGSNTEL 266
K + G +TF C A+G+P+PAI W R G ++ +L
Sbjct: 320 --KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 267 TVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV-----QPHIIQLK--NETTYENGQVT 319
T+ N+ SD G Y+C+ N AG +A+L+V P +I+ N+T +G
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYD 379
L C A G P+P I W++ DG + + D RI+ Q + L I+ KL D+GRY
Sbjct: 438 LSCVATGSPVPTILWRK--DGVLVS----TQDSRIK---QLENGVLQIRYAKLGDTGRYT 488
Query: 380 CEAASRIGGHQKSMYLDIEY------------------APKF-----ISNQTIYYSWEGN 416
C A++ G S Y++++ AP +S T+ SW+ N
Sbjct: 489 CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
Query: 417 PINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCT 476
+ + A H A+N +KT ++ K + N +
Sbjct: 549 LNSGATPTSYIIEAFSHASGSSWQTVAEN---VKTETSAIKGL------KPNAIYLFLVR 599
Query: 477 ATNHIGTRFQEYI---LALADVPSSPYGV--KIIELSQTTAKVSFNKPDSHGGVPIH-HY 530
A N G I + DV + GV K ++ A + + P I H+
Sbjct: 600 AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW 659
Query: 531 QVDVKEVASEIWKIV-----RSHG------------VQTMVVLNNLEPNTTYEIRVAAVN 573
VD + + +KI+ +HG + VV+ +L YEI+
Sbjct: 660 TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 574 GKGQGDYSKIEIFQTLPVREPSPP---SIHGQPSSGKSFKLS--ITKQDDGGAPILEYIV 628
+ QG S+I+ +TL +PP ++ +G + +S +D + EY V
Sbjct: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
Query: 629 KYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLG---YSEPTVYEFSMP 685
+ ++ + K V G+ +++ L + Y V++ A+ G SEP +
Sbjct: 780 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAH 838
Query: 686 PKPNIIKDTLFNGLGLGAVI-------GLGVAALLLILV 717
P +D + + V+ G+G A ++++V
Sbjct: 839 GNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMV 877
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 142 bits (359), Expect = 1e-33
Identities = 162/705 (22%), Positives = 283/705 (40%), Gaps = 92/705 (13%)
Query: 21 LQVTISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLT 79
L VT++ K++ +G + +C G PE +I WY + +++ + + L
Sbjct: 375 LHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWY--RNTELVLPDEAISIRGLSNETLL 432
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQE--FKQGEDAEVVCR 137
I +A +G Y+C AT K QT + ++ + + T R V S E GE ++C
Sbjct: 433 ITSAQKSHSGAYQCFAT-RKAQTAQDFAIIAL-EDGTPRIVSSFSEKVVNPGEQFSLMCA 490
Query: 138 VSSSPAPAVSWLYHNEEVT---TISDNRFAMLANNNLQILNINK---SDEGIYRCEGRVE 191
+P P V+W +E + + N++ M + +N+ D G+YRC R
Sbjct: 491 AKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR-N 549
Query: 192 ARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI 251
G +++ + V PP+I + N TA G + +CR G P +I W+++ L+
Sbjct: 550 LVGSAEYQ-ARINVRGPPSIRAMR---NITAVAGRDTLINCRVIGYPYYSIKWYKDALLL 605
Query: 252 EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNET 311
+N + ++ + T D G Y+C + Q+ P +IQ
Sbjct: 606 PDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFP 665
Query: 312 TYENGQVTLV-CDAEGEPIP-EITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKD 369
GQ+ + C +P ITW++ DG G + ++ + SSL I
Sbjct: 666 PASIGQLLYIPCVVSSGDMPIRITWRK--DGQVIISG-----SGVTIESKEFMSSLQISS 718
Query: 370 VKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFI---SNQTIYYSWEGNPINISCDVKS 426
V L +G Y C A++ + L + P+F+ +NQ Y G ++C V
Sbjct: 719 VSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAG---VLNCSVDG 775
Query: 427 NPPASIHWRRDKLVLPAKNTTNLKTYS----TGRKMILE-----IAPTSDNDFGRYNCTA 477
PP + W+ AK + N + Y TGR IL I + D G Y C A
Sbjct: 776 YPPPKVMWKH------AKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQA 829
Query: 478 TNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPD----SHGGVPI------ 527
+N +GT + + +P+ I TT + + + + G PI
Sbjct: 830 SNGVGTDISKSMFLTVKIPA-----MITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK 884
Query: 528 ----------HHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQ 577
Y + K+ E+ ++ L + + A+N G+
Sbjct: 885 GDTVIDPDRVMRYAIATKDNGDEVVSTLK---------LKPADRGDSVFFSCHAINSYGE 935
Query: 578 GDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKED 637
D I++ P P PP + + +S L T++ DG + I + ++Y K+K D
Sbjct: 936 -DRGLIQLTVQEP---PDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEY--KNKSD 989
Query: 638 QWLEKKVQGNKDHII----LEHLQWTMGYEVQITAANRLGYSEPT 678
W K+ N I + L Y +++ + N++G SEP+
Sbjct: 990 SWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPS 1034
Score = 110 bits (275), Expect = 5e-24
Identities = 125/473 (26%), Positives = 192/473 (40%), Gaps = 43/473 (9%)
Query: 31 ELSVGESKFFTCTAIGEP-ESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAG 89
E+ G + CTA G P +I W G + + R + G LTI + ED+G
Sbjct: 296 EVWAGHTVELPCTASGYPIPAIRWLK-DGRPLPADSRWTKRITG----LTISDLRTEDSG 350
Query: 90 IYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVV--CRVSSSPAPAVS 147
Y C+ T+ G EAT +L + L ++P++ K G + V+ C ++ SP +
Sbjct: 351 TYICEVTNTFGSA-EATGILMVIDPL--HVTLTPKKLKTGIGSTVILSCALTGSPEFTIR 407
Query: 148 WLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNV 207
W + E V L+N L I + KS G Y+C +A+ DF I +
Sbjct: 408 WYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT 467
Query: 208 PPAISMPQKSFNA-TAERGEEMTFSCRASGSPEPAISWFRNGKLI-----EENEKYILKG 261
P +S SF+ GE+ + C A G+P P ++W + + I +Y +
Sbjct: 468 PRIVS----SFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSD 523
Query: 262 SNT--ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVT 319
T + V DGG Y C A N G E QA + V P I ++N T
Sbjct: 524 GTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTL 583
Query: 320 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDV-KLSDSGRY 378
+ C G P I W + + D +V ++G +L + DV K D G Y
Sbjct: 584 INCRVIGYPYYSIKW--------YKDALLLPDNHRQVVFENG--TLKLTDVQKGMDEGEY 633
Query: 379 DCEAASRIGGHQKSMYLDIEYA---PKFISNQTIYYSWEGNPINISCDVKS-NPPASIHW 434
C + Q S+ + A P I + G + I C V S + P I W
Sbjct: 634 LCSVLIQ---PQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITW 690
Query: 435 RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQE 487
R+D V+ + + ++ S L+I+ S G Y C A+N T +E
Sbjct: 691 RKDGQVIISGSGVTIE--SKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE 741
Score = 109 bits (272), Expect = 1e-23
Identities = 95/361 (26%), Positives = 153/361 (42%), Gaps = 27/361 (7%)
Query: 124 QEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGI 183
QE G E+ C S P PA+ WL + +D+R+ L I ++ D G
Sbjct: 295 QEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP--ADSRWTKRI-TGLTISDLRTEDSGT 351
Query: 184 YRCE-----GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSP 238
Y CE G EA G I++V P +++ K G + SC +GSP
Sbjct: 352 YICEVTNTFGSAEATG-------ILMVIDPLHVTLTPKKLKTGI--GSTVILSCALTGSP 402
Query: 239 EPAISWFRNGKLIEENEKYILKG-SNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQ 297
E I W+RN +L+ +E ++G SN L + + S G Y C AT KA + A +
Sbjct: 403 EFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIA 462
Query: 298 V-FVQPHIIQLKNETTYENG-QVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIE 355
+ P I+ +E G Q +L+C A+G P P +TW A+D +
Sbjct: 463 LEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW--ALDDEPIVRDGSHRTNQYT 520
Query: 356 VKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEG 415
+ S +++ ++ D G Y C A + +G + +++ P + + I + G
Sbjct: 521 MSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNI-TAVAG 579
Query: 416 NPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNC 475
I+C V P SI W +D L+LP + + G + ++ D G Y C
Sbjct: 580 RDTLINCRVIGYPYYSIKWYKDALLLP--DNHRQVVFENGTLKLTDVQKGMDE--GEYLC 635
Query: 476 T 476
+
Sbjct: 636 S 636
Score = 88.6 bits (218), Expect = 2e-17
Identities = 158/699 (22%), Positives = 274/699 (39%), Gaps = 85/699 (12%)
Query: 26 SLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNAN 84
++ + G C IG P SI WY + R VV + G +
Sbjct: 570 AMRNITAVAGRDTLINCRVIGYPYYSIKWYK-DALLLPDNHRQVVFENGTLKLTDVQKGM 628
Query: 85 IEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQ---GEDAEVVCRVSSS 141
D G Y C + ++ ++ + ++ P EF G+ + C VSS
Sbjct: 629 --DEGEYLCSVLIQP----QLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSG 682
Query: 142 PAPA-VSWLYHNEEV-----TTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
P ++W + + TI F ++LQI +++ G Y C A
Sbjct: 683 DMPIRITWRKDGQVIISGSGVTIESKEFM----SSLQISSVSLKHNGNYTCIAS-NAAAT 737
Query: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE 255
+ R+ +IV VPP + N G+ +C G P P + W ++ K +
Sbjct: 738 VS-RERQLIVRVPPRFVVQPN--NQDGIYGKAGVLNCSVDGYPPPKVMW-KHAKGSGNPQ 793
Query: 256 KYI---LKGS-----NTELTVRNIINSDGGPYVCRATNKAGED-EKQAFLQVFVQPHIIQ 306
+Y L G N+ L +R+++ D G Y+C+A+N G D K FL V + I
Sbjct: 794 QYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITS 853
Query: 307 LKNETTYENGQV-TLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVK--GQHGSS 363
N T G L C A GE I W++ G T + D+ + I K G S
Sbjct: 854 HPNTTIAIKGHAKELNCTARGERPIIIRWEK---GDTVIDPDRVMRYAIATKDNGDEVVS 910
Query: 364 SLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP-------KFISNQTIYYSW--- 413
+L +K DS + C A + G + + L ++ P + + +++ W
Sbjct: 911 TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQR 970
Query: 414 -EGNPINISCDVK-SNPPASIHWRRD-KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDF 470
+GN I D++ N S +++ + + P N N I+++ P S
Sbjct: 971 FDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQAN----------IVDLHPASVYSI 1020
Query: 471 GRYNCTATNHIGTRFQEYILALADVPSSPYG----VKIIELSQTTAKVSFNKP--DSHGG 524
Y + N IG L ++ ++P G V + ++ + +V++ P + G
Sbjct: 1021 RMY---SFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG 1077
Query: 525 VPIHHYQVDVKE---VASEIWKIV--RSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGD 579
V I YQ+ +E ++ + IV ++ G + L+NL+ Y + V A N G G
Sbjct: 1078 V-IRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGP 1136
Query: 580 YSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYR----SKDK 635
S EI T PS P + + S S I+ + + + + YR S
Sbjct: 1137 -SSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYV 1195
Query: 636 EDQWLE-KKVQGNKDHIILEHLQWTMGYEVQITAANRLG 673
+ +W E + + ++ + L ++ Y VQ+ A + G
Sbjct: 1196 DGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAG 1234
Score = 80.9 bits (198), Expect = 5e-15
Identities = 138/642 (21%), Positives = 243/642 (37%), Gaps = 101/642 (15%)
Query: 33 SVGESKFFTCTAIGE--PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGI 90
S+G+ + C P I W G+ IIS V ++ + S L I + +++ G
Sbjct: 668 SIGQLLYIPCVVSSGDMPIRITW-RKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGN 726
Query: 91 YRCQATDAKGQTQEATVVLEIYQKLTFREVVSP--QEFKQGEDAEVVCRVSSSPAPAVSW 148
Y C A++A ++ ++ R VV P Q+ G+ + C V P P V W
Sbjct: 727 YTCIASNAAATVSRER---QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMW 783
Query: 149 L----------YHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDF 198
YH +T R +L N++L I ++ + D G Y C+ +I
Sbjct: 784 KHAKGSGNPQQYHPVPLT----GRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDIS- 838
Query: 199 RDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE--K 256
+ + + V +P I+ + A +G +C A G I W + +I+ + +
Sbjct: 839 KSMFLTVKIPAMITSHPNT--TIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMR 896
Query: 257 YILKGSN------TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLK-N 309
Y + + + L ++ D + C A N GED L V P +L+
Sbjct: 897 YAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIR 956
Query: 310 ETTYENGQVTLVCDAEGEPIP---EITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLH 366
E + + +G I +I +K D + F + +++ I + +
Sbjct: 957 EVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTI--------NQAN 1008
Query: 367 IKDVKLSDSGRYDCEAASRIGGHQKSMYLDI---EYAPKFISNQTIYYSWEGNPINISCD 423
I D+ + + ++IG + S L I E AP +G P++++
Sbjct: 1009 IVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAP------------DGPPMDVTLQ 1056
Query: 424 VKSNPPASIHWRRDKLVLPAKNTTN--LKTY----------STGRKMILEIAPTSDND-- 469
++ + W+ P K N ++ Y S G+ I+E+ T D++
Sbjct: 1057 PVTSQSIQVTWKA-----PKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVY 1111
Query: 470 -------FGRYNCT--ATNHIGT---RFQEYILALADVPSSP-YGVKIIELSQTTAKVSF 516
F +Y A N GT + L DVPS P V+ + ++ A +S+
Sbjct: 1112 TLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISW 1171
Query: 517 NKPDSHG------GVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVA 570
++P G + + + V E+ I + + V L +E T Y ++V
Sbjct: 1172 SEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTT---RERVELRGMEKFTNYSVQVL 1228
Query: 571 AVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLS 612
A G G S + QT P I PSS S +S
Sbjct: 1229 AYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVS 1270
Score = 66.2 bits (160), Expect = 1e-10
Identities = 65/268 (24%), Positives = 119/268 (44%), Gaps = 18/268 (6%)
Query: 418 INISCDVKSNPPASIHWRRDK--LVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNC 475
+ + C+ +P ++ W +D +P + ++ G ++ + D G Y C
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKA---EDSGYYTC 1423
Query: 476 TATNHIGTRFQEYIL-ALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
TATN G F I+ L VP + + + S ++ +++ P +GG I + +
Sbjct: 1424 TATNTGG--FDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQY 1480
Query: 535 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP 594
SE WK V + L++L+ T Y++++AA N G G S+I I REP
Sbjct: 1481 SVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEI-IEAKTHGREP 1539
Query: 595 S---PPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKD-H 650
S + +S + +L++ ++GG PI +++YR K W + ++ N
Sbjct: 1540 SFSKDQHLFTHINSTHA-RLNLQGWNNGGCPITAIVLEYRPK---GTWAWQGLRANSSGE 1595
Query: 651 IILEHLQWTMGYEVQITAANRLGYSEPT 678
+ L L+ YE+++ A N G T
Sbjct: 1596 VFLTELREATWYELRMRACNSAGCGNET 1623
Score = 47.0 bits (110), Expect = 7e-05
Identities = 66/297 (22%), Positives = 110/297 (37%), Gaps = 44/297 (14%)
Query: 226 EEMTFS--------CRASGSPEPAISWF-RNGKLIEENEKYILKGSNTELTV----RNII 272
+++TFS C A+GSP A+ W+ G I + +N L + +
Sbjct: 93 QQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAF 152
Query: 273 NS--DGGPYVCRATNKAGE--DEKQAFLQVFVQPHIIQLKNETTYENGQVTLVC---DAE 325
NS Y C A N AG+ VF +P+ ++++++ + C +
Sbjct: 153 NSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSV 212
Query: 326 GEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDS-GRYDCEAAS 384
E + ++W++ + R + HG L+I DV+ D+ Y C
Sbjct: 213 QEYVSVVSWEKDTVSII-------PEHRFFIT-YHG--GLYISDVQKEDALSTYRCITKH 262
Query: 385 RIGGHQK-------SMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD 437
+ G + S+ E P + W G+ + + C P +I W +D
Sbjct: 263 KYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKD 322
Query: 438 KLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALAD 494
LPA + T R L I+ D G Y C TN G+ IL + D
Sbjct: 323 GRPLPADSRW------TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
Score = 44.3 bits (103), Expect = 5e-04
Identities = 72/331 (21%), Positives = 130/331 (39%), Gaps = 31/331 (9%)
Query: 318 VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGR 377
V L C++ G+P P + W + + S+DG + H + +L ++ VK DSG
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPV---SMDGHRLI---HTNGTLLLRAVKAEDSGY 1420
Query: 378 YDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD 437
Y C A + G + L ++ P + + I ++ N +SI R
Sbjct: 1421 YTCTATNTGGFDTIIVNLLVQVPPD--QPRLTVSKTSASSITLTWIPGDNGGSSI--RGF 1476
Query: 438 KLVLPAKNTTNLK-TYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT-RFQEYILALADV 495
L N+ K + + + ++ + + A N +G+ R E I A
Sbjct: 1477 VLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536
Query: 496 PSSPYGVK---IIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQT 552
+ ++ T A+++ + ++GG PI ++ + + W+ +R++
Sbjct: 1537 REPSFSKDQHLFTHINSTHARLNL-QGWNNGGCPITAIVLEYRPKGTWAWQGLRANS-SG 1594
Query: 553 MVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLS 612
V L L T YE+R+ A N G G ++ F TL + P I G K
Sbjct: 1595 EVFLTELREATWYELRMRACNSAGCG--NETAQFATLDYDGSTIPPIKSAQGEGDDVKKL 1652
Query: 613 ITKQDDGGAPI--------LEYIVKYRSKDK 635
T G P+ L +IV+ + K+K
Sbjct: 1653 FTI----GCPVILATLGVALLFIVRKKRKEK 1679
Score = 41.2 bits (95), Expect = 0.004
Identities = 31/105 (29%), Positives = 46/105 (43%), Gaps = 7/105 (6%)
Query: 205 VNVPPAISMPQK--SFNATAERG--EEMTFSCRASGSPEPAISWFRNGK---LIEENEKY 257
V + PA P K SF T +++ C + G P PA+ W ++ + + + +
Sbjct: 1340 VTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
Query: 258 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
L +N L +R + D G Y C ATN G D L V V P
Sbjct: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
Score = 36.2 bits (82), Expect = 0.13
Identities = 25/103 (24%), Positives = 42/103 (40%), Gaps = 6/103 (5%)
Query: 130 EDAEVVCRVSSSPAPAVSWLYHNEE--VTTISDNRFAMLANNNLQILNINKSDEGIYRCE 187
+D + C PAPAV W +E+ + D + N L + + D G Y C
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTC- 1423
Query: 188 GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTF 230
G D + ++V VPP P+ + + T+ +T+
Sbjct: 1424 -TATNTGGFDTIIVNLLVQVPP--DQPRLTVSKTSASSITLTW 1463
Score = 31.2 bits (69), Expect = 4.2
Identities = 27/97 (27%), Positives = 40/97 (41%), Gaps = 3/97 (3%)
Query: 488 YILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVAS--EIWKIV 545
YI DVP P G+K + S ++ VS+ P GV I Y + S
Sbjct: 1243 YIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEY 1301
Query: 546 RSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSK 582
+ Q + +L Y + VAAV G+G+ S+
Sbjct: 1302 ETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE 1338
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 142 bits (357), Expect = 2e-33
Identities = 150/599 (25%), Positives = 237/599 (39%), Gaps = 68/599 (11%)
Query: 28 SKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRS---------- 76
S + +S GE C A G P +I+WY +RV K+ RS
Sbjct: 75 SDLIVSKGEPATLNCKAEGRPTPTIEWYK-------GGERVETDKDDPRSHRMLLPSGSL 127
Query: 77 ---RLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEI-YQKLTFREVVSPQEFKQGEDA 132
R+ + D G+Y C A + G+ LE+ + FR+ S GE A
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 187
Query: 133 EVVCRVSSS-PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEG-RV 190
+ C+ P P +SW + D R + L I KSD G Y C G +
Sbjct: 188 VMECQPPRGHPEPTISWKKDGSPLDD-KDERIT-IRGGKLMITYTRKSDAGKYVCVGTNM 245
Query: 191 EARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKL 250
E + ++ V+ P + P N + F C A G P P + W ++
Sbjct: 246 VGERESEVAELTVLER-PSFVKRPS---NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 301
Query: 251 IEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE 310
+ ++ +Y ++ +T L +R + D G Y C A N G+ E A L V PH + +
Sbjct: 302 LPKS-RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRD 359
Query: 311 TTYENGQ-VTLVCDAEGEPIPEITWKR-AVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIK 368
G+ VT C+A G P P I W+R F+ R V + L I
Sbjct: 360 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ---TGDLTIT 416
Query: 369 DVKLSDSGRYDCEAASRIGGHQKSMYLDI-----EYAPKFIS----NQTIYYSWEGNPIN 419
+V+ SD G Y C+ + G YL++ + P I NQT+ + +G +
Sbjct: 417 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV--AVDGTFV- 473
Query: 420 ISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
+SC +P +I WR+D VL + + +K G +L+I D GRY C A+
Sbjct: 474 LSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLENG---VLQIRYAKLGDTGRYTCIAST 529
Query: 480 HIGT-------RFQEYILALAD--------VPSSPYGVKIIELSQTTAKVSFNKPDSHGG 524
G QE+ + + +PS+P ++ ++S+ T +S+ + G
Sbjct: 530 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 589
Query: 525 VPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKI 583
P + + W+ V + + L+PN Y V A N G D S+I
Sbjct: 590 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648
Score = 130 bits (326), Expect = 7e-30
Identities = 172/758 (22%), Positives = 299/758 (39%), Gaps = 110/758 (14%)
Query: 44 AIGEPESIDWYNPQG--EKIISTQRVVVQKEGVRSRLTIYNANI-------EDAGIYRCQ 94
A+GEP ++ P+G E IS ++ + R+TI + DAG Y C
Sbjct: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 241
Query: 95 ATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEE 154
T+ G+ + L + ++ +F + S + AE C P P V W + E
Sbjct: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 301
Query: 155 VTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMP 214
+ +R+ + ++ L+I + D G Y C G+ + + + P + P
Sbjct: 302 ---LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE-NMVGKAEASATLTVQEPPHFVVKP 357
Query: 215 QKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI-------EENEKYILKGSNTELT 267
+ A G +TF C A+G+P+PAI W R G ++ +LT
Sbjct: 358 RDQVVAL---GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414
Query: 268 VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV-----QPHIIQLK--NETTYENGQVTL 320
+ N+ SD G Y+C+ N AG +A+L+V P +I+ N+T +G L
Sbjct: 415 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 474
Query: 321 VCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDC 380
C A G P+P I W++ DG + + D RI+ Q + L I+ KL D+GRY C
Sbjct: 475 SCVATGSPVPTILWRK--DGVLVS----TQDSRIK---QLENGVLQIRYAKLGDTGRYTC 525
Query: 381 EAASRIGGHQKSMYLDIEY------------------APKF-----ISNQTIYYSWEGNP 417
A++ G S Y++++ AP +S T+ SW+ N
Sbjct: 526 IASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL 585
Query: 418 INISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTA 477
+ + A H A+N +KT ++ K + N + A
Sbjct: 586 NSGATPTSYIIEAFSHASGSSWQTVAEN---VKTETSAIKGL------KPNAIYLFLVRA 636
Query: 478 TNHIGTRFQEYI---LALADVPSSPYGV--KIIELSQTTAKVSFNKPDSHGGVPIH-HYQ 531
N G I + DV + GV K ++ A + + P I H+
Sbjct: 637 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 696
Query: 532 VDVKEVASEIWKIV-----RSHG------------VQTMVVLNNLEPNTTYEIRVAAVNG 574
VD + + +KI+ +HG + VV+ +L YEI+
Sbjct: 697 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 756
Query: 575 KGQGDYSKIEIFQTLPVREPSPP---SIHGQPSSGKSFKLS--ITKQDDGGAPILEYIVK 629
+ QG S+I+ +TL +PP ++ +G + +S +D + EY V
Sbjct: 757 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV- 815
Query: 630 YRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLG---YSEPTVYEFSMPP 686
+ ++ + K V G+ +++ L + Y V++ A+ G SEP +
Sbjct: 816 WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHG 875
Query: 687 KPNIIKDTLFNGLGLGAVI-------GLGVAALLLILV 717
P +D + + V+ G+G A ++++V
Sbjct: 876 NPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMV 913
Score = 31.2 bits (69), Expect = 4.2
Identities = 24/109 (22%), Positives = 44/109 (40%), Gaps = 23/109 (21%)
Query: 388 GHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHW------------- 434
G+ S ++ P+ + + + +G P ++C + P +I W
Sbjct: 55 GYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD 114
Query: 435 -RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
R +++LP+ + L+ GRK S D G Y C A N++G
Sbjct: 115 PRSHRMLLPSGSLFFLRIVH-GRK--------SRPDEGVYVCVARNYLG 154
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 142 bits (357), Expect = 2e-33
Identities = 112/418 (26%), Positives = 177/418 (42%), Gaps = 40/418 (9%)
Query: 105 ATVVLEIYQKLTFREVVSPQ--EFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNR 162
A+V +E + + R PQ E G CR +P P + W+++N + D R
Sbjct: 222 ASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTR 281
Query: 163 FAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPA----ISMPQKSF 218
+ + L I N +SD+G+Y+C R A GE + ++ + PA + PQ
Sbjct: 282 LNVFDDGTLMIRNTRESDQGVYQCMARNSA-GEAKTQSAMLRYSSLPAKPSFVIQPQ--- 337
Query: 219 NATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGP 278
+ G T C A+G P P I+W R+ L + +++ S L ++NI D G
Sbjct: 338 DTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGR 395
Query: 279 YVCRATNKAGEDEKQAFLQVFVQPHI-IQLKNETTYENGQVTLVCDAEGEPIPEITWKRA 337
+ C A N G + A + V P + K++ E V +C+A+G P P I W +
Sbjct: 396 FTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKT 455
Query: 338 VDGFTFTEGDKSLDGRIEVKGQH---GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMY 394
G++ V+GQH S +L I D G+Y+C+A S +G + S+
Sbjct: 456 -------------GGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQ 502
Query: 395 LDIEYAPKFISNQTIY---YSWE-GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLK 450
L ++ PK ++ T S E G INISC + P I W ++ + + ++
Sbjct: 503 LTVK--PKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD 560
Query: 451 TYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELS 508
T L I D GRY C A N G L + + G +E S
Sbjct: 561 DEGT-----LTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESS 613
Score = 124 bits (311), Expect = 4e-28
Identities = 108/392 (27%), Positives = 172/392 (43%), Gaps = 45/392 (11%)
Query: 22 QVTISLSKVELSVGESKFFTCTAIGEPE-SIDW-YNPQGEKIISTQRVVVQKEGVRSRLT 79
++T VE+ G + +FTC A G P+ I W +N + R+ V +G L
Sbjct: 235 RITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT---LM 291
Query: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFRE--VVSPQ--EFKQGEDAEVV 135
I N D G+Y+C A ++ G+ + + +L Y L + V+ PQ E G +
Sbjct: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLR-YSSLPAKPSFVIQPQDTEVLIGTSTTLE 350
Query: 136 CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRC-----EGRV 190
C + P P ++W N D + ++ L + NI + D G + C G V
Sbjct: 351 CMATGHPHPLITWTRDN---GLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTV 407
Query: 191 EARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKL 250
+A I IV PP ++ K E E + C A G+P P I W + G
Sbjct: 408 QAAANI-------IVQAPPQFTVTPKDQVVLEEHAVE--WLCEADGNPPPVIVWTKTGGQ 458
Query: 251 IEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII----Q 306
+ ++ + S T L + D G Y C+A + G K+ +Q+ V+P + Q
Sbjct: 459 LPVEGQHTVLSSGT-LRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLTVKPKALAVFTQ 515
Query: 307 LKNETTYENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSL 365
L +T+ E G+ + + C A+GEP P ITW + +G TE G+ V + +L
Sbjct: 516 LPQDTSVEVGKNINISCHAQGEPQPIITWNK--EGVQITE-----SGKFHVDDE---GTL 565
Query: 366 HIKDVKLSDSGRYDCEAASRIGGHQKSMYLDI 397
I D D GRY+C A + G +M+L +
Sbjct: 566 TIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
Score = 44.3 bits (103), Expect = 5e-04
Identities = 28/83 (33%), Positives = 42/83 (50%), Gaps = 3/83 (3%)
Query: 18 QALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSR 77
+AL T + VG++ +C A GEP+ I +N +G +I + + V EG
Sbjct: 508 KALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT--- 564
Query: 78 LTIYNANIEDAGIYRCQATDAKG 100
LTIY+A D G Y C A ++ G
Sbjct: 565 LTIYDAGFPDQGRYECVARNSFG 587
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,363,361
Number of Sequences: 37866
Number of extensions: 1609984
Number of successful extensions: 13087
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 314
Number of HSP's successfully gapped in prelim test: 261
Number of HSP's that attempted gapping in prelim test: 4035
Number of HSP's gapped (non-prelim): 3825
length of query: 837
length of database: 18,247,518
effective HSP length: 111
effective length of query: 726
effective length of database: 14,044,392
effective search space: 10196228592
effective search space used: 10196228592
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.