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Search of human proteins with 33469982
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 1033 0.0
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 652 0.0
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 634 0.0
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 634 0.0
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 633 0.0
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 631 0.0
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 570 e-162
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 558 e-159
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 557 e-159
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 553 e-157
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 553 e-157
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 545 e-155
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 545 e-155
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 545 e-155
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 490 e-138
gi|4503787 fyn-related kinase [Homo sapiens] 446 e-125
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 354 1e-97
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 344 9e-95
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 344 9e-95
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 344 9e-95
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 344 9e-95
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 344 9e-95
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 340 2e-93
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 340 2e-93
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 330 2e-90
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 323 3e-88
gi|148596974 TXK tyrosine kinase [Homo sapiens] 322 5e-88
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 319 3e-87
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 305 5e-83
gi|187475373 c-src tyrosine kinase [Homo sapiens] 293 3e-79
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 1033 bits (2670), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK 60
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
Sbjct: 1 MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK 60
Query: 61 HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE 120
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
Sbjct: 61 HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE 120
Query: 121 MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR 180
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
Sbjct: 121 MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR 180
Query: 181 CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS 240
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
Sbjct: 181 CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS 240
Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
Sbjct: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
Sbjct: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
Query: 361 LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS 420
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
Sbjct: 361 LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS 420
Query: 421 FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER 480
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
Sbjct: 421 FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER 480
Query: 481 PTFEFLQSVLEDFYTATERQYELQP 505
PTFEFLQSVLEDFYTATERQYELQP
Sbjct: 481 PTFEFLQSVLEDFYTATERQYELQP 505
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 652 bits (1681), Expect = 0.0
Identities = 312/463 (67%), Positives = 381/463 (82%), Gaps = 3/463 (0%)
Query: 45 NHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGR 104
+H + P + VVALYDY A++ DL KG+++ VL+ +G+WW ARSL T +
Sbjct: 65 SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRK 124
Query: 105 EGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSV 164
EGY+PSN+VARV+SLE E WFF+ RK+AERQLLAP N GSF+IR+SET KG++SLSV
Sbjct: 125 EGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSV 184
Query: 165 KDVTT-QGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRP 223
+D QG+ +KHYKIR LD GG+YISPR TF +LQ LV HY K DGLCQ+L++PC+
Sbjct: 185 RDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSS 244
Query: 224 APQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLG 283
PQ PW +D WEIPR+SL+L +KLG+GQFGEVWM Y + KVA+KT+K G+MS EAFL
Sbjct: 245 KPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLA 304
Query: 284 EANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQ 343
EANVMK LQH++LV+L+AVVTKEPIYI+TE+MA+G LLDFLK+DEGS+ LP+LID SAQ
Sbjct: 305 EANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 364
Query: 344 IAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWT 402
IAEGMA+IE+ N IHRDLRAANILVS +L CKIADFGLAR+I D+EYTA+EGAKFPIKWT
Sbjct: 365 IAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWT 424
Query: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462
APEAI+FG FTIK+DVWSFG+LLME+VTYGR+PYPGMSNPEVIR LERGYRMPRP+ CP
Sbjct: 425 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPE 484
Query: 463 ELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
ELY ++ CW++RPEERPTFE++QSVL+DFYTATE QY+ QP
Sbjct: 485 ELY-NIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 526
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 634 bits (1634), Expect = 0.0
Identities = 305/470 (64%), Positives = 382/470 (81%), Gaps = 11/470 (2%)
Query: 40 PLVVFNHLTPP--PPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLA 97
PLV + PP P ++L V+AL+ Y +D DL KGE+L++L+ +G+WW A
Sbjct: 47 PLVTYEGSNPPASPLQDNL------VIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA 100
Query: 98 RSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNK 157
+SL TG+EG++P NFVA+ SLE E WFF++ RK+AERQLLAP N GSFLIRESE+
Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
Query: 158 GAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRL 216
G+FSLSV+D QGE++KHYKIR LD GG+YISPRITFP L LV+HY+ DGLC RL
Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
Query: 217 TLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTM 276
+ PC PQ PW +DEWE+PR++L+LV +LG+GQFGEVWMGYY + KVA+K+LK+G+M
Sbjct: 221 SRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280
Query: 277 SPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336
SP+AFL EAN+MK LQH+RLVRLYAVVT+EPIYI+TEYM G L+DFLKT G +L++ +
Sbjct: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINK 340
Query: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGA 395
L+DM+AQIAEGMA+IE N IHRDLRAANILVS+ L CKIADFGLAR+I D+EYTA+EGA
Sbjct: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400
Query: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455
KFPIKWTAPEAI++G FTIK+DVWSFG+LL E+VT+GR+PYPGM+NPEVI+NLERGYRM
Sbjct: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460
Query: 456 RPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
RPD CP ELY+ ++ CW+ RPE+RPTF++L+SVLEDF+TATE QY+ QP
Sbjct: 461 RPDNCPEELYQ-LMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 634 bits (1634), Expect = 0.0
Identities = 305/470 (64%), Positives = 382/470 (81%), Gaps = 11/470 (2%)
Query: 40 PLVVFNHLTPP--PPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLA 97
PLV + PP P ++L V+AL+ Y +D DL KGE+L++L+ +G+WW A
Sbjct: 47 PLVTYEGSNPPASPLQDNL------VIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA 100
Query: 98 RSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNK 157
+SL TG+EG++P NFVA+ SLE E WFF++ RK+AERQLLAP N GSFLIRESE+
Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
Query: 158 GAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRL 216
G+FSLSV+D QGE++KHYKIR LD GG+YISPRITFP L LV+HY+ DGLC RL
Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
Query: 217 TLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTM 276
+ PC PQ PW +DEWE+PR++L+LV +LG+GQFGEVWMGYY + KVA+K+LK+G+M
Sbjct: 221 SRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280
Query: 277 SPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336
SP+AFL EAN+MK LQH+RLVRLYAVVT+EPIYI+TEYM G L+DFLKT G +L++ +
Sbjct: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINK 340
Query: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGA 395
L+DM+AQIAEGMA+IE N IHRDLRAANILVS+ L CKIADFGLAR+I D+EYTA+EGA
Sbjct: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400
Query: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455
KFPIKWTAPEAI++G FTIK+DVWSFG+LL E+VT+GR+PYPGM+NPEVI+NLERGYRM
Sbjct: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460
Query: 456 RPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
RPD CP ELY+ ++ CW+ RPE+RPTF++L+SVLEDF+TATE QY+ QP
Sbjct: 461 RPDNCPEELYQ-LMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 633 bits (1632), Expect = 0.0
Identities = 312/517 (60%), Positives = 396/517 (76%), Gaps = 17/517 (3%)
Query: 1 MGLVSSKKPD---------KEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPP 51
MG + SK D K +P++ ++ + S + + P L+
Sbjct: 1 MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD 60
Query: 52 PDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSN 111
P+E D VVALY Y ++ DL KGEK++VL+ G+WW A+SL+T +EG++PSN
Sbjct: 61 PEEQGD----IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSN 116
Query: 112 FVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQ 170
+VA++ +LE E WFF+ RK+AERQLLAP N AG+FLIRESET KG+FSLSV+D
Sbjct: 117 YVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVH 176
Query: 171 GELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA 230
G++IKHYKIR LD GGYYISPRITFP + +++HY K+ DGLC+RL C+ P PQ PW
Sbjct: 177 GDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD 236
Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKA 290
+D WEIPR+S++LV++LG+GQFGEVWMGYY N+ KVA+KTLK GTMS +AFL EAN+MK
Sbjct: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKT 296
Query: 291 LQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMA 349
LQH++LVRLYAVVT+ EPIYI+TEYMA+G LLDFLK+DEG ++ LP+LID SAQIAEGMA
Sbjct: 297 LQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMA 356
Query: 350 YIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIH 408
YIER N IHRDLRAAN+LVSE+L CKIADFGLAR+I D+EYTA+EGAKFPIKWTAPEAI+
Sbjct: 357 YIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 416
Query: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGV 468
FG FTIK+DVWSFG+LL E+VTYG++PYPG +N +V+ L +GYRMPR + CP ELY +
Sbjct: 417 FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELY-DI 475
Query: 469 IAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
+ CW+ + EERPTF++LQSVL+DFYTATE QY+ QP
Sbjct: 476 MKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 631 bits (1627), Expect = 0.0
Identities = 310/494 (62%), Positives = 386/494 (78%), Gaps = 9/494 (1%)
Query: 15 IKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMND 74
IK K K S V + + P L T P +E VVALY Y ++
Sbjct: 4 IKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDP-----EEQGDIVVALYPYDGIHP 58
Query: 75 RDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEA 134
DL KGEK++VL+ G+WW A+SL+T +EG++PSN+VA++ +LE E WFF+ RK+A
Sbjct: 59 DDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDA 118
Query: 135 ERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRI 193
ERQLLAP N AG+FLIRESET KG+FSLSV+D G++IKHYKIR LD GGYYISPRI
Sbjct: 119 ERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRI 178
Query: 194 TFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFG 253
TFP + +++HY K+ DGLC+RL C+ P PQ PW +D WEIPR+S++LV++LG+GQFG
Sbjct: 179 TFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFG 238
Query: 254 EVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTK-EPIYIVT 312
EVWMGYY N+ KVA+KTLK GTMS +AFL EAN+MK LQH++LVRLYAVVT+ EPIYI+T
Sbjct: 239 EVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIIT 298
Query: 313 EYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEAL 372
EYMA+G LLDFLK+DEG ++ LP+LID SAQIAEGMAYIER N IHRDLRAAN+LVSE+L
Sbjct: 299 EYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESL 358
Query: 373 CCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTY 431
CKIADFGLAR+I D+EYTA+EGAKFPIKWTAPEAI+FG FTIK+DVWSFG+LL E+VTY
Sbjct: 359 MCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTY 418
Query: 432 GRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE 491
G++PYPG +N +V+ L +GYRMPR + CP ELY ++ CW+ + EERPTF++LQSVL+
Sbjct: 419 GKIPYPGRTNADVMTALSQGYRMPRVENCPDELY-DIMKMCWKEKAEERPTFDYLQSVLD 477
Query: 492 DFYTATERQYELQP 505
DFYTATE QY+ QP
Sbjct: 478 DFYTATEGQYQQQP 491
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 570 bits (1469), Expect = e-162
Identities = 283/446 (63%), Positives = 349/446 (78%), Gaps = 8/446 (1%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
VALYDY A + DL KGEK Q+L + GDWW ARSL TG GY+PSN+VA V+S++ E
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
W+F GRK+AERQLL+ N G+FLIRESET KGA+SLS++D +G+ +KHYKIR
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQ----NPWAQDEWEIP 237
LD GGYYI+ R F +LQ LVQHYS++ GLC RL +PC + P+ + +D WEIP
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIP 267
Query: 238 RQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLV 297
R+SL+L+++LG+GQFGEVWMG + N KVAIKTLK GTMSPE+FL EA +MK L+H++LV
Sbjct: 268 RESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLV 327
Query: 298 RLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSI 357
+LYAVV++EPIYIVTEYM +G LLDFLK EG L LP L+DM+AQ+A GMAYIERMN I
Sbjct: 328 QLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387
Query: 358 HRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKA 416
HRDLR+ANILV L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+
Sbjct: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447
Query: 417 DVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSR 476
DVWSFG+LL E+VT GRVPYPGM+N EV+ +ERGYRMP P CP L+ ++ CW+
Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKD 506
Query: 477 PEERPTFEFLQSVLEDFYTATERQYE 502
PEERPTFE+LQS LED++TATE QY+
Sbjct: 507 PEERPTFEYLQSFLEDYFTATEPQYQ 532
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 558 bits (1438), Expect = e-159
Identities = 281/443 (63%), Positives = 341/443 (76%), Gaps = 5/443 (1%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
VALYDY A + DL KGEK Q+L + GDWW ARSL TG GY+PSN+VA V+S++ E
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
W+F GRK+AERQLL+ N G+FLIRESET KGA+SLS++D +G+ +KHYKIR
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
LD GGYYI+ R F +LQ LVQHYS+K DGLC LT+ PQ A+D WE+ R+S
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRS 267
Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
L L +KLG G F EVW+G + N KVAIKTLK GTMSPE+FL EA +MK L+H++LV+LY
Sbjct: 268 LCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 327
Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
AVV++EPIYIVTEYM +G LLDFLK EG L LP L+DM+AQ+A GMAYIERMN IHRD
Sbjct: 328 AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRD 387
Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
LR+ANILV L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVW
Sbjct: 388 LRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 447
Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
SFG+LL E+VT GRVPYPGM+N EV+ +ERGYRMP P CP L+ ++ CW+ PEE
Sbjct: 448 SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEE 506
Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
RPTFE+LQS LED++TATE QY+
Sbjct: 507 RPTFEYLQSFLEDYFTATEPQYQ 529
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 557 bits (1436), Expect = e-159
Identities = 277/443 (62%), Positives = 340/443 (76%), Gaps = 5/443 (1%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
VALYDY A DL KGE+ Q++ T GDWW ARS+ TG+ GY+PSN+VA +S++ E
Sbjct: 97 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAE 156
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
W+F GRK+AER LL P N+ G FL+RESET KGA+SLS++D +G+ +KHYKIR
Sbjct: 157 EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRK 216
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
LD GGYYI+ R F +LQ LV+HY++ DGLC +LT C PQ A+D WEIPR+S
Sbjct: 217 LDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRES 276
Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
LRL KLG G FGEVWMG + KVAIKTLK GTM PEAFL EA +MK L+H++LV LY
Sbjct: 277 LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY 336
Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
AVV++EPIYIVTE+M++G LLDFLK +G L LP+L+DM+AQIA+GMAYIERMN IHRD
Sbjct: 337 AVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRD 396
Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
LRAANILV E L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVW
Sbjct: 397 LRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 456
Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
SFG+L E+VT GRVPYPGM N EV+ +ERGYRMP P CP L+ ++ CW+ P+E
Sbjct: 457 SFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE-LMNLCWKKDPDE 515
Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
RPTFE++QS LED++TATE QY+
Sbjct: 516 RPTFEYIQSFLEDYFTATEPQYQ 538
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 553 bits (1426), Expect = e-157
Identities = 278/443 (62%), Positives = 338/443 (76%), Gaps = 5/443 (1%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
VALYDY + + DL KGE+LQ++ T GDWWLA SL TG+ GY+PSN+VA +S++ E
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDV-TTQGELIKHYKIRC 181
W+F R+E+ER LL N G+FL+RESET KGA+ LSV D +G +KHYKIR
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
LD GG+YI+ R F SLQ LV +YSK DGLC RLT C PQ A+D WEIPR+S
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
LRL KLG G FGEVWMG + +VAIKTLK GTMSPEAFL EA VMK L+HE+LV+LY
Sbjct: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
AVV++EPIYIVTEYM++G LLDFLK + G L LP+L+DM+AQIA GMAY+ERMN +HRD
Sbjct: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389
Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
LRAANILV E L CK+ADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVW
Sbjct: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449
Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
SFG+LL E+ T GRVPYPGM N EV+ +ERGYRMP P CP L+ ++ +CWR PEE
Sbjct: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH-DLMCQCWRKEPEE 508
Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
RPTFE+LQ+ LED++T+TE QY+
Sbjct: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 553 bits (1426), Expect = e-157
Identities = 278/443 (62%), Positives = 338/443 (76%), Gaps = 5/443 (1%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
VALYDY + + DL KGE+LQ++ T GDWWLA SL TG+ GY+PSN+VA +S++ E
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDV-TTQGELIKHYKIRC 181
W+F R+E+ER LL N G+FL+RESET KGA+ LSV D +G +KHYKIR
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
LD GG+YI+ R F SLQ LV +YSK DGLC RLT C PQ A+D WEIPR+S
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
LRL KLG G FGEVWMG + +VAIKTLK GTMSPEAFL EA VMK L+HE+LV+LY
Sbjct: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
AVV++EPIYIVTEYM++G LLDFLK + G L LP+L+DM+AQIA GMAY+ERMN +HRD
Sbjct: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389
Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
LRAANILV E L CK+ADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVW
Sbjct: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449
Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
SFG+LL E+ T GRVPYPGM N EV+ +ERGYRMP P CP L+ ++ +CWR PEE
Sbjct: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH-DLMCQCWRKEPEE 508
Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
RPTFE+LQ+ LED++T+TE QY+
Sbjct: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 545 bits (1403), Expect = e-155
Identities = 271/443 (61%), Positives = 336/443 (75%), Gaps = 5/443 (1%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
+ALYDY A + DL KGEK +L T GDWW ARSL +G+ G +PSN+VA V+S++ E
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRC 181
W+F GRK+AERQLL+P N G+FLIRESET KGA+SLS++D T+G+ +KHYKIR
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN-PWAQDEWEIPRQS 240
LD GGYYI+ R+ F S+Q LVQHY + DGLC L PC PQ A+D WEI R S
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSS 262
Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
+ L R+LG+G FG+VW+G + + KVA+KTLK GTMSP+AFL EA VMK L+H++LV+LY
Sbjct: 263 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 322
Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
AVV++EPIYIVTE+M G LLDFLK EG L LP+L+DM+AQ+AEGMAY+ERMN IHRD
Sbjct: 323 AVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRD 382
Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
LRAANILV E L CKIADFGLAR+I D EY +G+KFPIKWTAPEA FG FTIK+DVW
Sbjct: 383 LRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVW 442
Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
SFG+LL E++T GR+PYPGM+ EV+ +E+GY MP P CP LY + + WR PEE
Sbjct: 443 SFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEE 501
Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
RPTFE+LQS LED++T+ E QY+
Sbjct: 502 RPTFEYLQSFLEDYFTSAEPQYQ 524
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 545 bits (1403), Expect = e-155
Identities = 271/443 (61%), Positives = 336/443 (75%), Gaps = 5/443 (1%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
+ALYDY A + DL KGEK +L T GDWW ARSL +G+ G +PSN+VA V+S++ E
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRC 181
W+F GRK+AERQLL+P N G+FLIRESET KGA+SLS++D T+G+ +KHYKIR
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN-PWAQDEWEIPRQS 240
LD GGYYI+ R+ F S+Q LVQHY + DGLC L PC PQ A+D WEI R S
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSS 262
Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
+ L R+LG+G FG+VW+G + + KVA+KTLK GTMSP+AFL EA VMK L+H++LV+LY
Sbjct: 263 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 322
Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
AVV++EPIYIVTE+M G LLDFLK EG L LP+L+DM+AQ+AEGMAY+ERMN IHRD
Sbjct: 323 AVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRD 382
Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
LRAANILV E L CKIADFGLAR+I D EY +G+KFPIKWTAPEA FG FTIK+DVW
Sbjct: 383 LRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVW 442
Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
SFG+LL E++T GR+PYPGM+ EV+ +E+GY MP P CP LY + + WR PEE
Sbjct: 443 SFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEE 501
Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
RPTFE+LQS LED++T+ E QY+
Sbjct: 502 RPTFEYLQSFLEDYFTSAEPQYQ 524
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 545 bits (1403), Expect = e-155
Identities = 271/443 (61%), Positives = 336/443 (75%), Gaps = 5/443 (1%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
+ALYDY A + DL KGEK +L T GDWW ARSL +G+ G +PSN+VA V+S++ E
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRC 181
W+F GRK+AERQLL+P N G+FLIRESET KGA+SLS++D T+G+ +KHYKIR
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN-PWAQDEWEIPRQS 240
LD GGYYI+ R+ F S+Q LVQHY + DGLC L PC PQ A+D WEI R S
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSS 262
Query: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
+ L R+LG+G FG+VW+G + + KVA+KTLK GTMSP+AFL EA VMK L+H++LV+LY
Sbjct: 263 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 322
Query: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
AVV++EPIYIVTE+M G LLDFLK EG L LP+L+DM+AQ+AEGMAY+ERMN IHRD
Sbjct: 323 AVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRD 382
Query: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
LRAANILV E L CKIADFGLAR+I D EY +G+KFPIKWTAPEA FG FTIK+DVW
Sbjct: 383 LRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVW 442
Query: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
SFG+LL E++T GR+PYPGM+ EV+ +E+GY MP P CP LY + + WR PEE
Sbjct: 443 SFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEE 501
Query: 480 RPTFEFLQSVLEDFYTATERQYE 502
RPTFE+LQS LED++T+ E QY+
Sbjct: 502 RPTFEYLQSFLEDYFTSAEPQYQ 524
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 490 bits (1261), Expect = e-138
Identities = 256/442 (57%), Positives = 309/442 (69%), Gaps = 55/442 (12%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
VALYDY A + DL KGEK Q+L + GDWW ARSL TG GY+PSN+VA V+S++ E
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
W+F GRK+AERQLL+ N G+FLIRESET KGA+SLS++D +G+ +KHYKIR
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSL 241
LD GGYYI+ R F +LQ LVQHYS
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYS----------------------------------- 232
Query: 242 RLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYA 301
G + N KVAIKTLK GTMSPE+FL EA +MK L+H++LV+LYA
Sbjct: 233 ----------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYA 276
Query: 302 VVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDL 361
VV++EPIYIVTEYM +G LLDFLK EG L LP L+DM+AQ+A GMAYIERMN IHRDL
Sbjct: 277 VVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDL 336
Query: 362 RAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS 420
R+ANILV L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVWS
Sbjct: 337 RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 396
Query: 421 FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER 480
FG+LL E+VT GRVPYPGM+N EV+ +ERGYRMP P CP L+ ++ CW+ PEER
Sbjct: 397 FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEER 455
Query: 481 PTFEFLQSVLEDFYTATERQYE 502
PTFE+LQS LED++TATE QY+
Sbjct: 456 PTFEYLQSFLEDYFTATEPQYQ 477
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 446 bits (1147), Expect = e-125
Identities = 229/452 (50%), Positives = 310/452 (68%), Gaps = 23/452 (5%)
Query: 61 HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGD-WWLARSLVTGREG-------YVPSNF 112
H+ VAL+DY A DL G+KLQVL + WW AR L R+G Y+PSN+
Sbjct: 45 HYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNY 104
Query: 113 VARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGE 172
VA SL+ E WFF + GR +AE+QLL NK GSFLIRESE+ KG FSLSV D G
Sbjct: 105 VAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD----GA 160
Query: 173 LIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVR---PAPQNPW 229
++KHY+I+ LDEGG++++ R F +L V HY+K DGLC +L PC++ PAP +
Sbjct: 161 VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLS 220
Query: 230 AQ--DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANV 287
+ D+WEI R S++L+++LGSGQFGEVW G + N VA+KTLK G+M P FL EA +
Sbjct: 221 YKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQI 280
Query: 288 MKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAE 346
MK L+H +L++LYAV T E PIYI+TE M G L ++L+ D GS++ L + +DM+AQ+A
Sbjct: 281 MKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVAS 340
Query: 347 GMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARI--IDSE--YTAQEGAKFPIKWT 402
GMAY+E N IHRDL A N+LV E K+ADFGLAR+ +D+E Y ++ K P+KWT
Sbjct: 341 GMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWT 400
Query: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462
APEAI F+IK+DVWSFG+LL E++TYG++PY GM+ +VI+ L + YR+P+P CP
Sbjct: 401 APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQ 460
Query: 463 ELYRGVIAECWRSRPEERPTFEFLQSVLEDFY 494
+ Y ++ ECW + P+ERPTFE L+ LED++
Sbjct: 461 QFY-NIMLECWNAEPKERPTFETLRWKLEDYF 491
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 354 bits (908), Expect = 1e-97
Identities = 195/448 (43%), Positives = 270/448 (60%), Gaps = 15/448 (3%)
Query: 49 PPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGRE--G 106
P P E +ALYD+TA +L + +G++L L+ G + AR L +G+ G
Sbjct: 42 PTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRL-SGQPSAG 100
Query: 107 YVPSNFVARV--ESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSV 164
VP VA+ E+L + W+F R +A++ LL+P N+ G+FLIR SE++ G +SLSV
Sbjct: 101 LVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSV 160
Query: 165 KDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPA 224
+ + HY++ +G Y+ FP L+ L+ +Y + L PC+
Sbjct: 161 RAQAK----VCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM--- 213
Query: 225 PQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGE 284
PQ QD WE P L RKLG G FGEVW G + ++ VAIK +K M E
Sbjct: 214 PQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKE 273
Query: 285 ANVMKALQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQ 343
+K L+HERL+RL+AV + EP+YIVTE M +G L FL T EG L LP L+ + Q
Sbjct: 274 IQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333
Query: 344 IAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWT 402
+AEGM+Y+E +HRDL A N+LV + L CK+ADFGLAR++ D Y+ +K P+KWT
Sbjct: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWT 393
Query: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462
APEA ++ VF+ K+DVWSFGVLL EV TYG+ PY GM+N E ++ + RGYR+PRP CP
Sbjct: 394 APEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPA 453
Query: 463 ELYRGVIAECWRSRPEERPTFEFLQSVL 490
E+Y ++ ECWRS PEERP+F L+ L
Sbjct: 454 EVY-VLMLECWRSSPEERPSFATLREKL 480
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 344 bits (883), Expect = 9e-95
Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)
Query: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
+ D + VALYD+ A D L + KGEKL+VL G+W RS +G+VPSN++
Sbjct: 91 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 148
Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 202
Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
HY+I +G Y++ F +L LV H+S DGL L P C +P
Sbjct: 203 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 262
Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
D+WE+ R + + KLG GQ+GEV++G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 263 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 322
Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
++H LV+L V T EP YIVTEYM G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382
Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 442
Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+GYRM +P+ CPP++Y
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 501
Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
++ CW+ P +RP+F E +
Sbjct: 502 LMRACWKWSPADRPSFAETHQAFETMF 528
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 344 bits (883), Expect = 9e-95
Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)
Query: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
+ D + VALYD+ A D L + KGEKL+VL G+W RS +G+VPSN++
Sbjct: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 163
Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 164 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 217
Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
HY+I +G Y++ F +L LV H+S DGL L P C +P
Sbjct: 218 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 277
Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
D+WE+ R + + KLG GQ+GEV++G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 278 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 337
Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
++H LV+L V T EP YIVTEYM G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 397
Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 398 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 457
Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+GYRM +P+ CPP++Y
Sbjct: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 516
Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
++ CW+ P +RP+F E +
Sbjct: 517 LMRACWKWSPADRPSFAETHQAFETMF 543
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 344 bits (883), Expect = 9e-95
Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)
Query: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
+ D + VALYD+ A D L + KGEKL+VL G+W RS +G+VPSN++
Sbjct: 85 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 142
Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 143 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 196
Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
HY+I +G Y++ F +L LV H+S DGL L P C +P
Sbjct: 197 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 256
Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
D+WE+ R + + KLG GQ+GEV++G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 257 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 316
Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
++H LV+L V T EP YIVTEYM G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 317 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 376
Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 377 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 436
Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+GYRM +P+ CPP++Y
Sbjct: 437 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 495
Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
++ CW+ P +RP+F E +
Sbjct: 496 LMRACWKWSPADRPSFAETHQAFETMF 522
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 344 bits (883), Expect = 9e-95
Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)
Query: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
+ D + VALYD+ A D L + KGEKL+VL G+W RS +G+VPSN++
Sbjct: 91 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 148
Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 202
Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
HY+I +G Y++ F +L LV H+S DGL L P C +P
Sbjct: 203 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 262
Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
D+WE+ R + + KLG GQ+GEV++G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 263 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 322
Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
++H LV+L V T EP YIVTEYM G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382
Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 442
Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+GYRM +P+ CPP++Y
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 501
Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
++ CW+ P +RP+F E +
Sbjct: 502 LMRACWKWSPADRPSFAETHQAFETMF 528
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 344 bits (883), Expect = 9e-95
Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)
Query: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
+ D + VALYD+ A D L + KGEKL+VL G+W RS +G+VPSN++
Sbjct: 70 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 127
Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 128 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 181
Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
HY+I +G Y++ F +L LV H+S DGL L P C +P
Sbjct: 182 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 241
Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
D+WE+ R + + KLG GQ+GEV++G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 242 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 301
Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
++H LV+L V T EP YIVTEYM G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 302 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 361
Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 362 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 421
Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+GYRM +P+ CPP++Y
Sbjct: 422 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 480
Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
++ CW+ P +RP+F E +
Sbjct: 481 LMRACWKWSPADRPSFAETHQAFETMF 507
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 340 bits (872), Expect = 2e-93
Identities = 191/457 (41%), Positives = 273/457 (59%), Gaps = 18/457 (3%)
Query: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
+ D + VALYD+ A D L + KGEKL+VL G+W A++ +G+VPSN++
Sbjct: 60 ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 117
Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 118 PVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---YEGR-V 171
Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA---- 230
HY+I +G Y+S F +L LV H+S DGL L P + +
Sbjct: 172 YHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 231
Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
D+WE+ R + + KLG GQ+GEV+ G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 232 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 291
Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
++H LV+L V T+EP YI+TE+M G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 351
Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 352 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 411
Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+ YRM RP+ CP ++Y
Sbjct: 412 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE- 470
Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQ 504
++ CW+ P +RP+F + E + + E++
Sbjct: 471 LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 507
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 340 bits (872), Expect = 2e-93
Identities = 191/457 (41%), Positives = 273/457 (59%), Gaps = 18/457 (3%)
Query: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
+ D + VALYD+ A D L + KGEKL+VL G+W A++ +G+VPSN++
Sbjct: 79 ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 136
Query: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 137 PVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---YEGR-V 190
Query: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA---- 230
HY+I +G Y+S F +L LV H+S DGL L P + +
Sbjct: 191 YHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 250
Query: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
D+WE+ R + + KLG GQ+GEV+ G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 251 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 310
Query: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
++H LV+L V T+EP YI+TE+M G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 311 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 370
Query: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 371 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 430
Query: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+ YRM RP+ CP ++Y
Sbjct: 431 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE- 489
Query: 468 VIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQ 504
++ CW+ P +RP+F + E + + E++
Sbjct: 490 LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 526
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 330 bits (846), Expect = 2e-90
Identities = 179/436 (41%), Positives = 256/436 (58%), Gaps = 11/436 (2%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTG----REGYVPSNFVARVESL 119
V L+D+ + D +L G+ V + WW A L +GYVP N++A E++
Sbjct: 14 VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73
Query: 120 EMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKI 179
E E WFF R EA R+L A N G+FLIR SE + LSV+D + ++HYKI
Sbjct: 74 ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT----QAVRHYKI 129
Query: 180 RCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQ 239
G +++ ++F SL LV ++ + RL PC + P+ D+WE PR+
Sbjct: 130 WRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPRE 189
Query: 240 SLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFL-GEANVMKALQHERLVR 298
L RKLGSG FGEV+ G +K+ ++VAIK + + + L E MK L+H+ ++
Sbjct: 190 EFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILA 249
Query: 299 LYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSI 357
LYAVV+ +P+YI+TE MA+G LL+ L+ + L + L+D++ Q+AEGM Y+E N I
Sbjct: 250 LYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYI 309
Query: 358 HRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKAD 417
HRDL A NILV E CK+ DFGLAR+I + P KWTAPEA+ G ++ K+D
Sbjct: 310 HRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSD 369
Query: 418 VWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRP 477
VWSFG+LL E+ + G+VPYPGMSN E ++ GYRMP P CPP +++ ++ CW P
Sbjct: 370 VWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK-LMLTCWCRDP 428
Query: 478 EERPTFEFLQSVLEDF 493
E+RP F+ L+ L F
Sbjct: 429 EQRPCFKALRERLSSF 444
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 323 bits (827), Expect = 3e-88
Identities = 188/476 (39%), Positives = 277/476 (58%), Gaps = 20/476 (4%)
Query: 38 LPPLVVFNHLTPPPPD--EHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL-KGTGDW 94
LPP PPPP E D + VVA+YD+ A DL++ +G++ +L K W
Sbjct: 157 LPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHW 216
Query: 95 WLARSLVTGREGYVPSNFVARVES--LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRE 152
W AR G EGY+PSN+V +S L+ W+ R+ R +AE QLL +K G F++R+
Sbjct: 217 WRARDKY-GNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRD 274
Query: 153 SETNKGAFSLSV--KDVTTQGELIKHYKIR--CLDEGGYYISPRITFPSLQALVQHYSKK 208
S + G +++S+ K +HY I+ YY++ + F S+ +++++
Sbjct: 275 S-SQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHN 333
Query: 209 GDGLCQRLTLPCVRPAPQNP----WAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNM 264
GL RL P P ++ ++WEI L +R+LGSG FG V +G ++
Sbjct: 334 AAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQY 393
Query: 265 KVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDF 323
KVAIK ++EG M E F+ EA VM L H +LV+LY V T++ PIYIVTE+M RGCLL+F
Sbjct: 394 KVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNF 453
Query: 324 LKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR 383
L+ +G S L+ M + EGM Y+ER + IHRDL A N LVSEA K++DFG+AR
Sbjct: 454 LRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMAR 512
Query: 384 -IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNP 442
++D +YT+ GAKFP+KW PE ++ F+ K+DVWSFGVL+ EV T GR+P+ +N
Sbjct: 513 YVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNY 572
Query: 443 EVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATE 498
EV+ + RG+R+ +P +Y V+ CW+ +PE RP+FE L +++ E
Sbjct: 573 EVVTMVTRGHRLYQPKLASNYVYE-VMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 322 bits (825), Expect = 5e-88
Identities = 183/457 (40%), Positives = 279/457 (61%), Gaps = 21/457 (4%)
Query: 49 PPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL-KGTGDWWLARSLVTGREGY 107
PP P + E+K V ALYD+ +L + + E+ +L K WW AR + G EG
Sbjct: 73 PPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRL-GNEGL 131
Query: 108 VPSNFVA--RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVK 165
+PSN+V ++ +LE+ W+ R+ R +AE LL +K G+F++R+S + G++++SV
Sbjct: 132 IPSNYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSR-HLGSYTISVF 189
Query: 166 DVTTQGE--LIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---- 219
+ IKHY+I+ D G +Y++ R F S+ L+ ++ GL RL P
Sbjct: 190 MGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLM 249
Query: 220 --CVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMS 277
C+ PA ++ ++WEI L ++++GSGQFG V +G ++++++VAIK + EG+MS
Sbjct: 250 GSCL-PATAG-FSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMS 307
Query: 278 PEAFLGEANVMKALQHERLVRLYAV-VTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336
E F+ EA VM L H +LV+LY V + ++P+YIVTE+M GCLL++L+ ++G +L
Sbjct: 308 EEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEM 366
Query: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR-IIDSEYTAQEGA 395
L+ + I EGM Y+ER IHRDL A N LVS KI+DFG+ R ++D EY + GA
Sbjct: 367 LLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGA 426
Query: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455
KFPIKW+ PE F ++ K+DVWSFGVL+ EV T G++P+ SN +V+ + G+R+
Sbjct: 427 KFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLY 486
Query: 456 RPDTCPPELYRGVIAECWRSRPEERPTF-EFLQSVLE 491
RP P +Y V+ CW +PE RPTF E L++V E
Sbjct: 487 RPHLAPMSIYE-VMYSCWHEKPEGRPTFAELLRAVTE 522
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 319 bits (818), Expect = 3e-87
Identities = 181/481 (37%), Positives = 282/481 (58%), Gaps = 23/481 (4%)
Query: 29 SAQDKDAPPLPPLVVFNHLT--PPPPDEHL----DEDKHFVVALYDYTAMNDRDLQMLKG 82
S+ K PLPP + + P PP+ + VVALYDY MN DLQ+ KG
Sbjct: 179 SSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKG 238
Query: 83 EKLQVLKGTG-DWWLARSLVTGREGYVPSNFVARVE-SLEMERWFFRSQGRKEAERQLLA 140
++ +L+ + WW AR G+EGY+PSN+V E S+EM W+ + R +AE QLL
Sbjct: 239 DEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLK 296
Query: 141 PINKAGSFLIRESETNKGAFSLSVKDVTT---QGELIKHYKIRCLDEGGYYISPRITFPS 197
K G F++R+S + G +++SV +T QG +I+HY + + YY++ + F +
Sbjct: 297 QEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQG-VIRHYVVCSTPQSQYYLAEKHLFST 354
Query: 198 LQALVQHYSKKGDGLCQRLTLPCVRPAPQNP----WAQDEWEIPRQSLRLVRKLGSGQFG 253
+ L+ ++ GL RL P + P WEI + L +++LG+GQFG
Sbjct: 355 IPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFG 414
Query: 254 EVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVT 312
V G ++ VAIK +KEG+MS + F+ EA VM L HE+LV+LY V TK+ PI+I+T
Sbjct: 415 VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIIT 474
Query: 313 EYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEAL 372
EYMA GCLL++L+ + R +L++M + E M Y+E +HRDL A N LV++
Sbjct: 475 EYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG 533
Query: 373 CCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTY 431
K++DFGL+R ++D EYT+ G+KFP++W+ PE + + F+ K+D+W+FGVL+ E+ +
Sbjct: 534 VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL 593
Query: 432 GRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE 491
G++PY +N E ++ +G R+ RP ++Y ++ CW + +ERPTF+ L S +
Sbjct: 594 GKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYT-IMYSCWHEKADERPTFKILLSNIL 652
Query: 492 D 492
D
Sbjct: 653 D 653
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 305 bits (782), Expect = 5e-83
Identities = 179/479 (37%), Positives = 271/479 (56%), Gaps = 29/479 (6%)
Query: 22 QWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLK 81
Q+ P K +++ PLPP N P+E + V+ALYDY + ++L + +
Sbjct: 145 QYDPTKNASKK----PLPPTPEDNRRPLWEPEETV------VIALYDYQTNDPQELALRR 194
Query: 82 GEKLQVLKGTG-DWWLARSLVTGREGYVPSNFVARVE--SLEMERWFFRSQGRKEAERQL 138
E+ +L + WW + G EGYVPS+++ +LE W+ +S R +AE+ L
Sbjct: 195 NEEYCLLDSSEIHWWRVQDR-NGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEK-L 252
Query: 139 LAPINKAGSFLIRESETNKGAFSLSVKD---VTTQGELIKHYKIRCLDEGG--YYISPRI 193
L K G+F++R+S T G +++SV V+ IKHY I+ ++ YY++ +
Sbjct: 253 LLDTGKEGAFMVRDSRT-AGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKY 311
Query: 194 TFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQD----EWEIPRQSLRLVRKLGS 249
F S+ L+ ++ G GL RL P + P +W I L V+++GS
Sbjct: 312 VFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGS 371
Query: 250 GQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PI 308
GQFG V +GY+ N KVAIKT++EG MS E F+ EA VM L H +LV+LY V ++ PI
Sbjct: 372 GQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPI 431
Query: 309 YIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILV 368
+V E+M GCL D+L+T G + L+ M + EGMAY+E IHRDL A N LV
Sbjct: 432 CLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLV 490
Query: 369 SEALCCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLME 427
E K++DFG+ R ++D +YT+ G KFP+KW +PE F ++ K+DVWSFGVL+ E
Sbjct: 491 GENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWE 550
Query: 428 VVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFL 486
V + G++PY SN EV+ ++ G+R+ +P +Y+ ++ CW+ RPE+RP F L
Sbjct: 551 VFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ-IMNHCWKERPEDRPAFSRL 608
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 293 bits (749), Expect = 3e-79
Identities = 174/445 (39%), Positives = 260/445 (58%), Gaps = 27/445 (6%)
Query: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGTGD--WWLARSLVTGREGYVPSNFVARVES--- 118
+A Y++ ++DL KG+ L ++ T D W+ A++ V GREG +P+N+V + E
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKA 73
Query: 119 ---LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIK 175
L + WF R++AER L P + G FL+RES G ++L V + G+ ++
Sbjct: 74 GTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCV---SCDGK-VE 127
Query: 176 HYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRP---APQNPWAQD 232
HY+I I + F +L LV+HY+ DGLC RL P V A Q+ + +
Sbjct: 128 HYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186
Query: 233 EWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQ 292
W + + L+L++ +G G+FG+V +G Y+ N KVA+K +K + +AFL EA+VM L+
Sbjct: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMTQLR 244
Query: 293 HERLVRLYAVVTKEP--IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAY 350
H LV+L V+ +E +YIVTEYMA+G L+D+L++ S L L+ S + E M Y
Sbjct: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304
Query: 351 IERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFG 410
+E N +HRDL A N+LVSE K++DFGL + S Q+ K P+KWTAPEA+
Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---TQDTGKLPVKWTAPEALREK 361
Query: 411 VFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIA 470
F+ K+DVWSFG+LL E+ ++GRVPYP + +V+ +E+GY+M PD CPP +Y V+
Sbjct: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE-VMK 420
Query: 471 ECWRSRPEERPTFEFLQSVLEDFYT 495
CW RP+F L+ LE T
Sbjct: 421 NCWHLDAAMRPSFLQLREQLEHIKT 445
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,898,258
Number of Sequences: 37866
Number of extensions: 1018077
Number of successful extensions: 5476
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 310
Number of HSP's that attempted gapping in prelim test: 3012
Number of HSP's gapped (non-prelim): 1276
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.