Search of human proteins with 122937514

Search of human proteins with 122937514

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937514 unc-13 homolog C [Homo sapiens]
         (2214 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937514 unc-13 homolog C [Homo sapiens]                         4415   0.0  
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]                  1850   0.0  
gi|122937247 unc-13 homolog A [Homo sapiens]                         1841   0.0  
gi|13384594 protein kinase C, gamma [Homo sapiens]                     82   6e-15
gi|46195765 unc-13 homolog D [Homo sapiens]                            80   3e-14
gi|4506067 protein kinase C, alpha [Homo sapiens]                      76   4e-13
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            75   5e-13
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            75   5e-13
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...    75   5e-13
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...    75   5e-13
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...    75   5e-13
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...    73   4e-12
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...    73   4e-12
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...    70   2e-11
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    70   2e-11
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]    69   4e-11
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi...    69   4e-11
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi...    69   4e-11
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi...    69   4e-11
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi...    69   4e-11
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi...    69   4e-11
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi...    69   4e-11
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom...    66   4e-10
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom...    66   4e-10
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom...    66   4e-10
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    65   1e-09
gi|21361472 neural precursor cell expressed, developmentally dow...    64   2e-09
gi|222352090 neural precursor cell expressed, developmentally do...    64   2e-09
gi|222352088 neural precursor cell expressed, developmentally do...    64   2e-09
gi|222352086 neural precursor cell expressed, developmentally do...    64   2e-09

>gi|122937514 unc-13 homolog C [Homo sapiens]
          Length = 2214

 Score = 4415 bits (11450), Expect = 0.0
 Identities = 2214/2214 (100%), Positives = 2214/2214 (100%)

Query: 1    MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFK 60
            MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFK
Sbjct: 1    MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFK 60

Query: 61   STVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQEL 120
            STVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQEL
Sbjct: 61   STVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQEL 120

Query: 121  SSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGA 180
            SSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGA
Sbjct: 121  SSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGA 180

Query: 181  LRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTH 240
            LRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTH
Sbjct: 181  LRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTH 240

Query: 241  DVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRR 300
            DVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRR
Sbjct: 241  DVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRR 300

Query: 301  ETRDIHDYIKHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFA 360
            ETRDIHDYIKHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFA
Sbjct: 301  ETRDIHDYIKHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFA 360

Query: 361  QRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKG 420
            QRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKG
Sbjct: 361  QRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKG 420

Query: 421  IPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTS 480
            IPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTS
Sbjct: 421  IPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTS 480

Query: 481  KPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSD 540
            KPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSD
Sbjct: 481  KPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSD 540

Query: 541  FFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDS 600
            FFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDS
Sbjct: 541  FFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDS 600

Query: 601  PKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEW 660
            PKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEW
Sbjct: 601  PKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEW 660

Query: 661  NQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNS 720
            NQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNS
Sbjct: 661  NQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNS 720

Query: 721  SPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWH 780
            SPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWH
Sbjct: 721  SPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWH 780

Query: 781  SRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQST 840
            SRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQST
Sbjct: 781  SRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQST 840

Query: 841  ANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDE 900
            ANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDE
Sbjct: 841  ANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDE 900

Query: 901  QMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPV 960
            QMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPV
Sbjct: 901  QMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPV 960

Query: 961  EITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQ 1020
            EITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQ
Sbjct: 961  EITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQ 1020

Query: 1021 VCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHV 1080
            VCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHV
Sbjct: 1021 VCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHV 1080

Query: 1081 FKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQ 1140
            FKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQ
Sbjct: 1081 FKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQ 1140

Query: 1141 DLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDF 1200
            DLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDF
Sbjct: 1141 DLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDF 1200

Query: 1201 VQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIF 1260
            VQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIF
Sbjct: 1201 VQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIF 1260

Query: 1261 GNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLS 1320
            GNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLS
Sbjct: 1261 GNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLS 1320

Query: 1321 GEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSN 1380
            GEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSN
Sbjct: 1321 GEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSN 1380

Query: 1381 GGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAV 1440
            GGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAV
Sbjct: 1381 GGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAV 1440

Query: 1441 MSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREN 1500
            MSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREN
Sbjct: 1441 MSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREN 1500

Query: 1501 FPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDN 1560
            FPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDN
Sbjct: 1501 FPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDN 1560

Query: 1561 CHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQE 1620
            CHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQE
Sbjct: 1561 CHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQE 1620

Query: 1621 LNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKD 1680
            LNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKD
Sbjct: 1621 LNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKD 1680

Query: 1681 AVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQL 1740
            AVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQL
Sbjct: 1681 AVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQL 1740

Query: 1741 NQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNN 1800
            NQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNN
Sbjct: 1741 NQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNN 1800

Query: 1801 IQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQ 1860
            IQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQ
Sbjct: 1801 IQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQ 1860

Query: 1861 MSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELW 1920
            MSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELW
Sbjct: 1861 MSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELW 1920

Query: 1921 KLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEV 1980
            KLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEV
Sbjct: 1921 KLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEV 1980

Query: 1981 VLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSK 2040
            VLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSK
Sbjct: 1981 VLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSK 2040

Query: 2041 DAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRK 2100
            DAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRK
Sbjct: 2041 DAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRK 2100

Query: 2101 QGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIA 2160
            QGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIA
Sbjct: 2101 QGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIA 2160

Query: 2161 EKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA 2214
            EKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA
Sbjct: 2161 EKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA 2214


>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
          Length = 1591

 Score = 1850 bits (4791), Expect = 0.0
 Identities = 893/1192 (74%), Positives = 1039/1192 (87%), Gaps = 6/1192 (0%)

Query: 1024 GAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFKK 1083
            G  GGLYGIDSMPDLRRKK LP+V D+++ + +RK+G++ AM  RTSL +EELK HV+KK
Sbjct: 405  GPAGGLYGIDSMPDLRRKKPLPLVSDLSL-VQSRKAGITSAMATRTSLKDEELKSHVYKK 463

Query: 1084 TLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLL 1143
            TLQALIYP+S T PHNFEVWTATTPTYCYECEGLLWGIARQGM+C ECGVKCHEKCQDLL
Sbjct: 464  TLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLL 523

Query: 1144 NADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDFVQF 1203
            NADCLQRAAEKS KHGAED+TQ II AMK+RMKIRE+N+PE+FEVI+++F ++K   VQ 
Sbjct: 524  NADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQ 583

Query: 1204 TKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNL 1263
             K  KQSVLDGTSKWSAKITITVV AQGLQAKDKTGSSDPYVTVQV K K+RTKTIFGNL
Sbjct: 584  MKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNL 643

Query: 1264 NPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEM 1323
            NPVW+EKF+FECHNS+DRIKVRVWDEDDDIKSRVKQ  K+ESDDFLGQTI+EVRTLSGEM
Sbjct: 644  NPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEM 703

Query: 1324 DVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGGV 1383
            DVWYNLEKRTDKSAVSGAIRL+I+VEIKGEEKVAPYH+QYTCLHENLFHYLT+++ +GGV
Sbjct: 704  DVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGV 763

Query: 1384 KIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMST 1443
            +IPE +GD+AWKV+FD+ +QEIVDEFAMRYGIESIYQAMTHF+CLSSKYMCPGVPAVMST
Sbjct: 764  RIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMST 823

Query: 1444 LLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPA 1503
            LLANINA+YAHTT STN  VSASDRFAA+NFG+E+F+KLLDQLHNSLRIDLS YR NFPA
Sbjct: 824  LLANINAYYAHTTASTN--VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPA 881

Query: 1504 SNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHE 1563
             + ERLQDLKSTVDLLTSITFFRMKV ELQSPP+AS VVKDCV+ACL+STY+YIF+NCH+
Sbjct: 882  GSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHD 941

Query: 1564 LYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNM 1623
            LYS+      KQ++P E+QGP+ +NLDFWP+LITL+V+II+EDK +YTPVLNQFPQELN+
Sbjct: 942  LYSR--QYQLKQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNV 999

Query: 1624 GKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVP 1683
            GK+SAE+MW LFA DMKYALEEHE   LCKS DYMNLHFKVKW +NEYVR+LP  +  VP
Sbjct: 1000 GKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVP 1059

Query: 1684 EYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQLNQS 1743
            EY  WFE FV+QWLDENEDVS+EFL GAL RDKKDGFQQTSEHALFSCSVVDVF QLNQS
Sbjct: 1060 EYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQS 1119

Query: 1744 FEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNNIQQ 1803
            FEII+KLECP+P  L+H MRRFAKTI KVL+QYA I+S DF ++C KE +PCILMNN+QQ
Sbjct: 1120 FEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQ 1179

Query: 1804 LRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQMSF 1863
            LRVQLEKMFE+MGGKELD EA+  LKELQVKL+ VLDELS+ +G SFQV I+EC++QM+ 
Sbjct: 1180 LRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMAD 1239

Query: 1864 ELNQMRANGNTTSN-KNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELWKL 1922
             L Q+R  GN + + + SAA DA+ VLR LMDFLD  L+L A +CEKTVLKRVLKELW++
Sbjct: 1240 ILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRV 1299

Query: 1923 VLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEVVL 1982
            V+N +E+ IVLPPLTDQTG Q+IF AAK+L  LSKLK+HM+RE+ R LTP+QCA++++ L
Sbjct: 1300 VMNTMERMIVLPPLTDQTGTQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLAL 1359

Query: 1983 ATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSKDA 2042
             TIKQYFHAGGNGLKK FLEKSPDLQSLRYALSLYTQTTD LIK F+ +QT+Q     D 
Sbjct: 1360 DTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDP 1419

Query: 2043 VGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRKQG 2102
            VG++S+ VD+   PGTG+HKVTVKV+A NDL WQT  MFRPFVEV ++GP+  DKKRK  
Sbjct: 1420 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFT 1479

Query: 2103 TKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEK 2162
            TK+KSN W+PKYNETF F+LG E  P +YEL + VKDYCFAREDR++G+ V+ L+++  K
Sbjct: 1480 TKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAK 1539

Query: 2163 GSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA 2214
            GS   W PL + I MDETGLTILRILSQR++D+VA+EFV+LKSE+RSTEE +
Sbjct: 1540 GSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS 1591


>gi|122937247 unc-13 homolog A [Homo sapiens]
          Length = 1791

 Score = 1841 bits (4769), Expect = 0.0
 Identities = 972/1595 (60%), Positives = 1176/1595 (73%), Gaps = 91/1595 (5%)

Query: 684  FDQQLDVYNKDLEYLGKCHSDLQD--DSESYDLTQDDNSSPCPGLDNEPQGQ----WVGQ 737
            F+  LD+  ++  Y  K    L    D + Y   QD+   P P   N+        W  Q
Sbjct: 215  FELPLDIPEEEARYWAKKLEQLNAMRDQDEYSF-QDEQDKPLPVPSNQCCNWNYFGWGEQ 273

Query: 738  YD-----SYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDA---PPKSWHSRLSIDL-S 788
            ++     +    +S+   +  N +   Y + S+  +   + +   PP       S  + S
Sbjct: 274  HNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHS 333

Query: 789  DKTFSFPKFGSTLQRAKSALEVVWNKSTQSLS-GYEDSGSSLMG------RFRTLSQSTA 841
             + FS P+  S    ++ A     ++ +  LS  ++    SL G      R R    S  
Sbjct: 334  YEEFSEPQALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCH 393

Query: 842  NESSTTLDSDVYTEPYYYKAEDEEDYTEP--VADNETDYVEVMEQV---LAKLENRTSIT 896
            +  S   DS  + +      ED ED+ E   + ++E +  E  E+V   L     R  + 
Sbjct: 394  SSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPEDEEELEEEEEEVPDDLGSYAQREDVA 453

Query: 897  ETDEQMQAYDHLSYETPYETPQDEGYDGP--ADDMV------SEEGLEPLNETSAEMEIR 948
              + +   +  +S        +D+    P  A DM       +     P  E   E E  
Sbjct: 454  VAEPK--DFKRISLPPAAPGKEDKAPVAPTEAPDMAKVAPKPATPDKVPAAEQIPEAEPP 511

Query: 949  EDENQNIPEQPVEITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSG 1008
            +DE    P +  E  + +      K   LRA+ K   +L+E    G+ S           
Sbjct: 512  KDEESFRPREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQEARGEGEMSK---------- 561

Query: 1009 NDLDASKFSALQVCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLA-ARKSGLSLAMVI 1067
                     +L   GG GGGL  IDSMPD+R++K +P+V D+AM+L  +RK+G++ A+  
Sbjct: 562  ---------SLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALAS 612

Query: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
             T LNNEELK HV+KKTLQALIYP+S T PHNFEVWTATTPTYCYECEGLLWGIARQGM+
Sbjct: 613  ST-LNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 671

Query: 1128 CLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFE 1187
            C ECGVKCHEKCQDLLNADCLQRAAEKSSKHGAED+TQ II  +K+RMKIRE+N+PE+FE
Sbjct: 672  CTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFE 731

Query: 1188 VIQEMFQISKEDFVQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTV 1247
            +IQE+F ++K    Q  KA KQSVLDGTSKWSAKI+ITVV AQGLQAKDKTGSSDPYVTV
Sbjct: 732  LIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTV 791

Query: 1248 QVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDD 1307
            QVGK K+RTKTI+GNLNPVW+E F+FECHNS+DRIKVRVWDEDDDIKSRVKQ FK+ESDD
Sbjct: 792  QVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDD 851

Query: 1308 FLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLH 1367
            FLGQTI+EVRTLSGEMDVWYNL+KRTDKSAVSGAIRL I+VEIKGEEKVAPYH+QYTCLH
Sbjct: 852  FLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLH 911

Query: 1368 ENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSC 1427
            ENLFH++T+V++NG VKIP+ KGD+AWKV++D+ +QEIVDEFAMRYG+ESIYQAMTHF+C
Sbjct: 912  ENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFAC 971

Query: 1428 LSSKYMCPGVPAVMSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLH 1487
            LSSKYMCPGVPAVMSTLLANINA+YAHTT STN  VSASDRFAA+NFG+E+F+KLLDQLH
Sbjct: 972  LSSKYMCPGVPAVMSTLLANINAYYAHTTASTN--VSASDRFAASNFGKERFVKLLDQLH 1029

Query: 1488 NSLRIDLSKYRENFPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVR 1547
            NSLRIDLS YR NFPAS+ ERLQDLKSTVDLLTSITFFRMKV ELQSPP+AS VVKDCV+
Sbjct: 1030 NSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVK 1089

Query: 1548 ACLDSTYKYIFDNCHELYSQ--LTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDE 1605
            ACL+STY+YIF+NCHELYS+   TDP+KK ++  E+QGP+ KNLDFW +LITL+V+II+E
Sbjct: 1090 ACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEE 1149

Query: 1606 DKTAYTPVLNQFPQELNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVK 1665
            DK +YTP LNQFPQELN+GKISAE+MW LFA DMKYA+EEH+  RLCKS DYMNLHFKVK
Sbjct: 1150 DKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVK 1209

Query: 1666 WFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSE 1725
            W YNEYV ELPAFKD VPEY  WFEPFV+QWLDENE+VS +FLHGAL RDKKDGFQQTSE
Sbjct: 1210 WLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSE 1269

Query: 1726 HALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFS 1785
            HALFSCSVVDVF+QLNQSFEIIKKLECP+P+ + H MRRFAKTI+ VLLQYA I+S DF+
Sbjct: 1270 HALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFA 1329

Query: 1786 SHC--DKENVPCILMNNIQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELS 1843
            S+C  +KE VPCILMNN QQLRVQLEKMFE+MGGKELD+EAS ILKELQVKL+ VLDELS
Sbjct: 1330 SYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELS 1389

Query: 1844 VTYGESFQVIIEECIKQMSFELNQMRANGNTTSNK-NSAAMDAEIVLRSLMDFLDKTLSL 1902
              +  SFQ  IEEC+KQM   L+Q++  GN  ++  +S A DA+ VL+ +MD LD  L+L
Sbjct: 1390 RVFATSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTL 1449

Query: 1903 SAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQT---------------------- 1940
             AKICEKTVLKRVLKELWKLV+N +EK IVLPPLTDQT                      
Sbjct: 1450 FAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPS 1509

Query: 1941 ---GPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEVVLATIKQYFHAGGNGLK 1997
               G QMIF AAK+LGQLSKLK+HM+RE+A+ LTP+QCA++E+ L TIKQYFHAGG GLK
Sbjct: 1510 HSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLK 1569

Query: 1998 KNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSKDAVGQISVHVDITATPG 2057
            K FLEKSPDLQSLRYALSLYTQ TD LIK F+ TQ++Q    +D VG++SVHV++   PG
Sbjct: 1570 KTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPG 1629

Query: 2058 TGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNET 2117
            TG+HKVTVKV+A NDL WQT+ +FRPF+EV I+GP L DKKRK  TK+K+N+W+PKYNE+
Sbjct: 1630 TGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNES 1689

Query: 2118 FQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNISM 2177
            FQF L  +  P  YEL + VKDYCFAREDR +G+ V+QL+ +A++GS   W PL + I M
Sbjct: 1690 FQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHM 1749

Query: 2178 DETGLTILRILSQRTSDDVAKEFVRLKSETRSTEE 2212
            D+TGLT+LRILSQR++D+VAKEFV+LKS+TRS EE
Sbjct: 1750 DDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEE 1784


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 64/263 (24%), Positives = 106/263 (40%), Gaps = 52/263 (19%)

Query: 1098 HNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSK 1157
            H F       PT+C  C   +WGI +QG++C  C    H +C + +  +C          
Sbjct: 36   HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC---------- 85

Query: 1158 HGAEDKTQTIITAMKERMKIREKNRPE--------VFEVIQEMFQISKEDF--------- 1200
             GA    QT     K + ++   + P         ++ ++ +  + S  +          
Sbjct: 86   PGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRS 145

Query: 1201 ------VQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQV----- 1249
                  V  T+   +  L+  +  + +I +TV  A+ L   D  G SDPYV +++     
Sbjct: 146  VPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPR 205

Query: 1250 GKNKRRTKTIFGNLNPVWDEKFYFECH--NSTDRIKVRVWDEDDDIKSRVKQHFKKESDD 1307
               K++T+T+   LNPVW+E F F     +   R+ V VWD D           +   +D
Sbjct: 206  NLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWD-----------RTSRND 254

Query: 1308 FLGQTIVEV-RTLSGEMDVWYNL 1329
            F+G     V   L   +D WY L
Sbjct: 255  FMGAMSFGVSELLKAPVDGWYKL 277



 Score = 34.3 bits (77), Expect = 1.4
 Identities = 27/75 (36%), Positives = 37/75 (49%), Gaps = 7/75 (9%)

Query: 2100 KQGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNI 2159
            KQ T+T   T +P +NETF F L    +PG  E  LSV+ + + R  R   M  +    +
Sbjct: 209  KQKTRTVKATLNPVWNETFVFNL----KPGDVERRLSVEVWDWDRTSRNDFMGAMSF-GV 263

Query: 2160 AE--KGSYGAWYPLL 2172
            +E  K     WY LL
Sbjct: 264  SELLKAPVDGWYKLL 278


>gi|46195765 unc-13 homolog D [Homo sapiens]
          Length = 1090

 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 107/542 (19%), Positives = 223/542 (41%), Gaps = 66/542 (12%)

Query: 1681 AVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQL 1740
            A+  +  WF+P +  WL +  + ++  +  A+  D+     + ++H+  +  +   FAQ+
Sbjct: 581  ALDNFHRWFQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELTKHSTSAVDLSTCFAQI 640

Query: 1741 NQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIV-------SSDFSSHCDKENV 1793
            + +    ++L+ P+PE    +  +F +   ++ L Y +++       SS         N+
Sbjct: 641  SHT---ARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQGQAANM 697

Query: 1794 PCILMNNIQQLRVQLEKMFESMGGKELDSEASTILK--ELQVKLSGVLDELSVTYGESFQ 1851
             C+++N+++QLR+ + K+   +  + L+     +L+  +LQ  L   L       G   +
Sbjct: 698  LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQSALAGLGHEIR 757

Query: 1852 VIIEECIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTV 1911
              +    +Q+  E+   +        + S   +  I+   LM FL+  L        +  
Sbjct: 758  TGVRTLAEQL--EVGIAKHIQKLVGVRESVLPEDAIL--PLMKFLEVELCYMNTNLVQEN 813

Query: 1912 LKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLT 1971
               +L  LW   L                    + + A    + S L  + ++       
Sbjct: 814  FSSLLTLLWTHTLT-------------------VLVEAAASQRSSSLASNRLK------- 847

Query: 1972 PRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDT 2031
                    + L  ++  FHA G GL    L  +   Q+L+  L L   ++  LI+K+  +
Sbjct: 848  --------IALQNLEICFHAEGCGLPPKALH-TATFQALQRDLELQAASSRELIRKYFCS 898

Query: 2032 Q-TSQSRSSKDAVGQISVHVDITATPGTGDHKVTVKVIAIND-LNWQTTAMFRPFVEVCI 2089
            +   Q+ ++ + +G ++V     A+    + K+ V++++ +  L   +     PFV++ +
Sbjct: 899  RIQQQAETTSEELGAVTVKASYRAS----EQKLRVELLSASSLLPLDSNGSSDPFVQLTL 954

Query: 2090 LGPNLGDKKRKQGTKTKSNTWSPKYNETFQFILGKEN-RPGAYELHLSVKDYCFAREDRI 2148
               +   +   + T+       P ++ETF+F++  E  R     L L+V DY     D +
Sbjct: 955  EPRHEFPELAARETQKHKKDLHPLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDL 1014

Query: 2149 IGMTVIQLQNIAEKGSYGAWYP------LLKNISMDETGLTILRILSQRTSDDVAKEFVR 2202
             G   + L+ +   G  G+  P       L        G  IL++L  R  D  A+ FVR
Sbjct: 1015 EGEAFLPLREV--PGLSGSEEPGEVPQTRLPLTYPAPNGDPILQLLEGRKGDREAQVFVR 1072

Query: 2203 LK 2204
            L+
Sbjct: 1073 LR 1074



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 88/410 (21%), Positives = 157/410 (38%), Gaps = 76/410 (18%)

Query: 1161 EDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDFVQFTKAAKQSVLDGTSKWSA 1220
            ED   T++  +            E+   +QE F +  E+  Q  +  ++       K   
Sbjct: 57   EDALYTVLHRLGHPEPNHVTEASELLRYLQEAFHVEPEEHQQTLQRVRE-----LEKPIF 111

Query: 1221 KITITVVSAQGLQAKDKTGSSDPYVTVQV-----------GKNKR--------------- 1254
             +  TV  A+G+  KD +G SDPY  + +           G   R               
Sbjct: 112  CLKATVKQAKGILGKDVSGFSDPYCLLGIEQGVGVPGGSPGSRHRQKAVVRHTIPEEETH 171

Query: 1255 RTKTIFGNLNPVWDEKFYFECHNSTDR-IKVRVWDED--DDIKSRV---------KQHFK 1302
            RT+ I   LNPVWDE F  E  + T+    + +WD D  + ++ ++         ++ FK
Sbjct: 172  RTQVITQTLNPVWDETFILEFEDITNASFHLDMWDLDTVESVRQKLGELTDLHGLRRIFK 231

Query: 1303 -----KESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVA 1357
                 K  DDFLG  ++ ++ L    D WY LE RT+     G   L+  +  K     A
Sbjct: 232  EARKDKGQDDFLGNVVLRLQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRRATSA 291

Query: 1358 -----PYHIQYTCLHENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMR 1412
                  Y +    L + + H +T+ ++          G  +W       +  ++   A +
Sbjct: 292  SRSQPSYTVHLHLLQQLVSHEVTQHEA----------GSTSWDGSLSPQAATVLFLHATQ 341

Query: 1413 YGIESIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTVSTNIQVSASDRFAAT 1472
              +   +Q+M  +   S  Y     P+  S LL  I +   +  +   ++    +  AA+
Sbjct: 342  KDLSDFHQSMAQWLAYSRLYQSLEFPS--SCLLHPITSI-EYQWIQGRLKAEQQEELAAS 398

Query: 1473 NFGREKFIKLLDQLHNSLRIDLSKYRENFPASNTERLQDLKSTVDLLTSI 1522
                  F  LL    + +R    ++R  FP S ++    L+S + +L  +
Sbjct: 399  ------FSSLLTYGLSLIR----RFRSVFPLSVSDSPARLQSLLRVLVQM 438



 Score = 32.3 bits (72), Expect = 5.3
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 7/60 (11%)

Query: 1221 KITITVVSAQGLQAKDKTGSSDPYVTVQVGKN-------KRRTKTIFGNLNPVWDEKFYF 1273
            K+ + ++SA  L   D  GSSDP+V + +           R T+    +L+P++DE F F
Sbjct: 926  KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLHPLFDETFEF 985


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 60/226 (26%), Positives = 90/226 (39%), Gaps = 47/226 (20%)

Query: 1098 HNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSK 1157
            H F       PT+C  C   +WG  +QG +C  C    H++C + +   C          
Sbjct: 37   HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---------- 86

Query: 1158 HGAEDKTQTIITAMKERMKIREKNRPE--------VFEVIQEMFQISKEDFVQFTKAAKQ 1209
             GA+    T     K + KI     P         ++ +I +  +    D        KQ
Sbjct: 87   PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM----NVHKQ 142

Query: 1210 SVL--------DGTSKWSA----------KITITVVSAQGLQAKDKTGSSDPYVTVQV-- 1249
             V+        D T K             K+ +TV  A+ L   D  G SDPYV +++  
Sbjct: 143  CVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIP 202

Query: 1250 ---GKNKRRTKTIFGNLNPVWDEKFYFECHNSTD--RIKVRVWDED 1290
                ++K++TKTI   LNP W+E F F+   S    R+ V +WD D
Sbjct: 203  DPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWD 248



 Score = 32.7 bits (73), Expect = 4.1
 Identities = 32/116 (27%), Positives = 57/116 (49%), Gaps = 10/116 (8%)

Query: 2060 DHKVTVKVI-AINDLNWQTTAMFRPFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNETF 2118
            D K+ V V  A N +      +  P+V++ ++     + K+K  TKT  +T +P++NE+F
Sbjct: 170  DEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQK--TKTIRSTLNPQWNESF 227

Query: 2119 QFILGKENRPGAYELHLSVKDYCFAREDR--IIGMTVIQLQNIAEKGSYGAWYPLL 2172
             F L    +P   +  LSV+ + + R  R   +G     +  + +  + G WY LL
Sbjct: 228  TFKL----KPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASG-WYKLL 278


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 75/337 (22%), Positives = 130/337 (38%), Gaps = 68/337 (20%)

Query: 1098 HNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSK 1157
            H F       PT+C  C   +WG  +QG +C  C    H++C + +   C       + K
Sbjct: 37   HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC-----PGADK 91

Query: 1158 HGAEDKTQTIITAMKERMKIREKNRPEVFE----VIQEMFQISKEDFVQFTKAAKQSVLD 1213
              A D  ++     K + KI   + P   +    ++  +     +         K+ V++
Sbjct: 92   GPASDDPRS-----KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146

Query: 1214 -----GTSKWSAK-------------ITITVVSAQGLQAKDKTGSSDPYVTVQV-----G 1250
                 GT     +             + + V  A+ L   D  G SDPYV +++      
Sbjct: 147  VPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206

Query: 1251 KNKRRTKTIFGNLNPVWDEKFYFECHNSTD--RIKVRVWDEDDDIKSRVKQHFKKESDDF 1308
            ++K++TKTI  +LNP W+E F F+   S    R+ V +WD   D+ SR         +DF
Sbjct: 207  ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDW--DLTSR---------NDF 255

Query: 1309 LGQTIVEVRTL-SGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLH 1367
            +G     +  L    +D W+ L  + +                 GE    P   + +  +
Sbjct: 256  MGSLSFGISELQKASVDGWFKLLSQEE-----------------GEYFNVPVPPEGSEAN 298

Query: 1368 ENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQE 1404
            E L       K + G K+PE K       F ++ +++
Sbjct: 299  EELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRD 335



 Score = 33.5 bits (75), Expect = 2.4
 Identities = 22/90 (24%), Positives = 46/90 (51%), Gaps = 5/90 (5%)

Query: 2083 PFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCF 2142
            P+V++ ++     + K+K  TKT   + +P++NETF+F L + ++     L + + D+  
Sbjct: 194  PYVKLKLIPDPKSESKQK--TKTIKCSLNPEWNETFRFQLKESDKD--RRLSVEIWDWDL 249

Query: 2143 AREDRIIGMTVIQLQNIAEKGSYGAWYPLL 2172
               +  +G     +  + +K S   W+ LL
Sbjct: 250  TSRNDFMGSLSFGISEL-QKASVDGWFKLL 278


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 75/337 (22%), Positives = 130/337 (38%), Gaps = 68/337 (20%)

Query: 1098 HNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSK 1157
            H F       PT+C  C   +WG  +QG +C  C    H++C + +   C       + K
Sbjct: 37   HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC-----PGADK 91

Query: 1158 HGAEDKTQTIITAMKERMKIREKNRPEVFE----VIQEMFQISKEDFVQFTKAAKQSVLD 1213
              A D  ++     K + KI   + P   +    ++  +     +         K+ V++
Sbjct: 92   GPASDDPRS-----KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146

Query: 1214 -----GTSKWSAK-------------ITITVVSAQGLQAKDKTGSSDPYVTVQV-----G 1250
                 GT     +             + + V  A+ L   D  G SDPYV +++      
Sbjct: 147  VPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206

Query: 1251 KNKRRTKTIFGNLNPVWDEKFYFECHNSTD--RIKVRVWDEDDDIKSRVKQHFKKESDDF 1308
            ++K++TKTI  +LNP W+E F F+   S    R+ V +WD   D+ SR         +DF
Sbjct: 207  ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDW--DLTSR---------NDF 255

Query: 1309 LGQTIVEVRTL-SGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLH 1367
            +G     +  L    +D W+ L  + +                 GE    P   + +  +
Sbjct: 256  MGSLSFGISELQKASVDGWFKLLSQEE-----------------GEYFNVPVPPEGSEAN 298

Query: 1368 ENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQE 1404
            E L       K + G K+PE K       F ++ +++
Sbjct: 299  EELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRD 335



 Score = 33.5 bits (75), Expect = 2.4
 Identities = 22/90 (24%), Positives = 46/90 (51%), Gaps = 5/90 (5%)

Query: 2083 PFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCF 2142
            P+V++ ++     + K+K  TKT   + +P++NETF+F L + ++     L + + D+  
Sbjct: 194  PYVKLKLIPDPKSESKQK--TKTIKCSLNPEWNETFRFQLKESDKD--RRLSVEIWDWDL 249

Query: 2143 AREDRIIGMTVIQLQNIAEKGSYGAWYPLL 2172
               +  +G     +  + +K S   W+ LL
Sbjct: 250  TSRNDFMGSLSFGISEL-QKASVDGWFKLL 278


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
            DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 39/105 (37%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 1071 LNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLE 1130
            L +++  M  F +    L   M     HNF+  T   PT+C  C G LWGI +QG KC +
Sbjct: 468  LISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKD 527

Query: 1131 CGVKCHEKCQDLLNADC--LQRAAEKSSKHGAEDKTQTIITAMKE 1173
            CG  CH++C+DLL   C    RA   SS HG+   + ++  A  E
Sbjct: 528  CGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDE 572


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
            DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 39/105 (37%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 1071 LNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLE 1130
            L +++  M  F +    L   M     HNF+  T   PT+C  C G LWGI +QG KC +
Sbjct: 468  LISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKD 527

Query: 1131 CGVKCHEKCQDLLNADC--LQRAAEKSSKHGAEDKTQTIITAMKE 1173
            CG  CH++C+DLL   C    RA   SS HG+   + ++  A  E
Sbjct: 528  CGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDE 572


>gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
            isoform 2 [Homo sapiens]
          Length = 689

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 39/105 (37%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 1071 LNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLE 1130
            L +++  M  F +    L   M     HNF+  T   PT+C  C G LWGI +QG KC +
Sbjct: 467  LISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKD 526

Query: 1131 CGVKCHEKCQDLLNADC--LQRAAEKSSKHGAEDKTQTIITAMKE 1173
            CG  CH++C+DLL   C    RA   SS HG+   + ++  A  E
Sbjct: 527  CGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDE 571


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens]
          Length = 762

 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 26/55 (47%), Positives = 39/55 (70%)

Query: 1097 PHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRA 1151
            PHNF+  T   PT+C  C G LWG+ +QG +C +CG+ CH++C+DL+  +C +RA
Sbjct: 506  PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA 560


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens]
          Length = 797

 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 26/55 (47%), Positives = 39/55 (70%)

Query: 1097 PHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRA 1151
            PHNF+  T   PT+C  C G LWG+ +QG +C +CG+ CH++C+DL+  +C +RA
Sbjct: 541  PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA 595


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
            sapiens]
          Length = 778

 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 39/127 (30%), Positives = 65/127 (51%), Gaps = 11/127 (8%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDR 1281
            + + V+ A+GL A D TG SDP+  V++  ++  T T++ NLNP W++ F F   +    
Sbjct: 407  LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV 466

Query: 1282 IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGA 1341
            ++V V+DED D            S DFLG+  + + ++       Y L+ +       G 
Sbjct: 467  LEVTVYDEDRD-----------RSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGV 515

Query: 1342 IRLKINV 1348
            I L+I+V
Sbjct: 516  IYLEIDV 522



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 41/125 (32%), Positives = 64/125 (51%), Gaps = 14/125 (11%)

Query: 1201 VQF-TKAAKQSVLDGTSK-WSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKT 1258
            VQF T++ + S L   S  W   ++IT++  + L+A D  G SDPYV  ++G  K ++K 
Sbjct: 228  VQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKI 287

Query: 1259 IFGNLNPVWDEKFYFECHNSTDR-IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVR 1317
            +   LNP W E+F F  +      I +  WD+D             + DDF+G+  V++ 
Sbjct: 288  MPKTLNPQWREQFDFHLYEERGGVIDITAWDKD-----------AGKRDDFIGRCQVDLS 336

Query: 1318 TLSGE 1322
             LS E
Sbjct: 337  ALSRE 341



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 33/100 (33%), Positives = 55/100 (55%), Gaps = 12/100 (12%)

Query: 1221 KITITVVSAQGLQAKDKTGSSDPYVTVQVG-KNKRRTKTIFGNLNPVWDEKFYFECHNST 1279
            ++ IT+   Q L A+D+ G+SDPYV  ++G K   R+K I  NLNPVW+EK      +  
Sbjct: 41   QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLR 100

Query: 1280 DRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTL 1319
            + + ++V+D D  ++           DDF+G   +++  L
Sbjct: 101  EPLYIKVFDYDFGLQ-----------DDFMGSAFLDLTQL 129


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
            sapiens]
          Length = 999

 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 39/127 (30%), Positives = 65/127 (51%), Gaps = 11/127 (8%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDR 1281
            + + V+ A+GL A D TG SDP+  V++  ++  T T++ NLNP W++ F F   +    
Sbjct: 628  LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV 687

Query: 1282 IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGA 1341
            ++V V+DED D            S DFLG+  + + ++       Y L+ +       G 
Sbjct: 688  LEVTVYDEDRD-----------RSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGV 736

Query: 1342 IRLKINV 1348
            I L+I+V
Sbjct: 737  IYLEIDV 743



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 41/125 (32%), Positives = 64/125 (51%), Gaps = 14/125 (11%)

Query: 1201 VQF-TKAAKQSVLDGTSK-WSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKT 1258
            VQF T++ + S L   S  W   ++IT++  + L+A D  G SDPYV  ++G  K ++K 
Sbjct: 449  VQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKI 508

Query: 1259 IFGNLNPVWDEKFYFECHNSTDR-IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVR 1317
            +   LNP W E+F F  +      I +  WD+D             + DDF+G+  V++ 
Sbjct: 509  MPKTLNPQWREQFDFHLYEERGGVIDITAWDKD-----------AGKRDDFIGRCQVDLS 557

Query: 1318 TLSGE 1322
             LS E
Sbjct: 558  ALSRE 562



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 33/100 (33%), Positives = 55/100 (55%), Gaps = 12/100 (12%)

Query: 1221 KITITVVSAQGLQAKDKTGSSDPYVTVQVG-KNKRRTKTIFGNLNPVWDEKFYFECHNST 1279
            ++ IT+   Q L A+D+ G+SDPYV  ++G K   R+K I  NLNPVW+EK      +  
Sbjct: 262  QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLR 321

Query: 1280 DRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTL 1319
            + + ++V+D D  ++           DDF+G   +++  L
Sbjct: 322  EPLYIKVFDYDFGLQ-----------DDFMGSAFLDLTQL 350


>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
          Length = 673

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
            R S + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG +
Sbjct: 513  RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 570

Query: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
            C ECG+ CH+ C+D +  +C +R   K
Sbjct: 571  CRECGLCCHKHCRDQVKVECKKRPGAK 597


>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapiens]
          Length = 576

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
            R S + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG +
Sbjct: 416  RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 473

Query: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
            C ECG+ CH+ C+D +  +C +R   K
Sbjct: 474  CRECGLCCHKHCRDQVKVECKKRPGAK 500


>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapiens]
          Length = 484

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
            R S + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG +
Sbjct: 324  RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 381

Query: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
            C ECG+ CH+ C+D +  +C +R   K
Sbjct: 382  CRECGLCCHKHCRDQVKVECKKRPGAK 408


>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapiens]
          Length = 639

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
            R S + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG +
Sbjct: 479  RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 536

Query: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
            C ECG+ CH+ C+D +  +C +R   K
Sbjct: 537  CRECGLCCHKHCRDQVKVECKKRPGAK 563


>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapiens]
          Length = 604

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
            R S + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG +
Sbjct: 444  RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 501

Query: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
            C ECG+ CH+ C+D +  +C +R   K
Sbjct: 502  CRECGLCCHKHCRDQVKVECKKRPGAK 528


>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapiens]
          Length = 581

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
            R S + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG +
Sbjct: 421  RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 478

Query: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
            C ECG+ CH+ C+D +  +C +R   K
Sbjct: 479  CRECGLCCHKHCRDQVKVECKKRPGAK 505


>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapiens]
          Length = 659

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
            R S + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG +
Sbjct: 499  RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 556

Query: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
            C ECG+ CH+ C+D +  +C +R   K
Sbjct: 557  CRECGLCCHKHCRDQVKVECKKRPGAK 583


>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
            sapiens]
          Length = 823

 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 36/127 (28%), Positives = 68/127 (53%), Gaps = 11/127 (8%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDR 1281
            + + V+ A  L A D +G SDP+  +++G ++ +T T++ NLNP W++ F F   +  D 
Sbjct: 511  LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570

Query: 1282 IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGA 1341
            ++V V+DED D           +  DFLG+  + + ++       Y L+ +  + A  G 
Sbjct: 571  LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619

Query: 1342 IRLKINV 1348
            I L++++
Sbjct: 620  IYLEMDL 626



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 39/139 (28%), Positives = 66/139 (47%), Gaps = 15/139 (10%)

Query: 1216 SKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQV-GKNKRRTKTIFGNLNPVWDEKFYFE 1274
            S ++  +TI +   + L  +D+ G+SDPYV  ++ GK   ++K I+ NLNPVWDE     
Sbjct: 190  SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249

Query: 1275 CHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTD 1334
              +   +++V+V+D D              + DF+G   V +  L       + L+    
Sbjct: 250  IQSLDQKLRVKVYDRD------------LTTSDFMGSAFVILSDLELNRTTEHILKLEDP 297

Query: 1335 KSAVS--GAIRLKINVEIK 1351
             S     G I L +N+ +K
Sbjct: 298  NSLEDDMGVIVLNLNLVVK 316



 Score = 40.8 bits (94), Expect = 0.015
 Identities = 29/107 (27%), Positives = 56/107 (52%), Gaps = 23/107 (21%)

Query: 1218 WSAKITITVVSAQGLQAKDKTGSS--DPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFEC 1275
            W+  I+IT+     L+ K+ +G S  + +V +++G  + ++KT+  + NP W E+F F  
Sbjct: 354  WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406

Query: 1276 HNSTDR---IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTL 1319
            H  +DR   + + VW +D+           K+ ++ LG   V++  L
Sbjct: 407  HYFSDRMGILDIEVWGKDN-----------KKHEERLGTCKVDISAL 442


>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
            sapiens]
          Length = 878

 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 36/127 (28%), Positives = 68/127 (53%), Gaps = 11/127 (8%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDR 1281
            + + V+ A  L A D +G SDP+  +++G ++ +T T++ NLNP W++ F F   +  D 
Sbjct: 511  LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570

Query: 1282 IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGA 1341
            ++V V+DED D           +  DFLG+  + + ++       Y L+ +  + A  G 
Sbjct: 571  LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619

Query: 1342 IRLKINV 1348
            I L++++
Sbjct: 620  IYLEMDL 626



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 39/139 (28%), Positives = 66/139 (47%), Gaps = 15/139 (10%)

Query: 1216 SKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQV-GKNKRRTKTIFGNLNPVWDEKFYFE 1274
            S ++  +TI +   + L  +D+ G+SDPYV  ++ GK   ++K I+ NLNPVWDE     
Sbjct: 190  SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249

Query: 1275 CHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTD 1334
              +   +++V+V+D D              + DF+G   V +  L       + L+    
Sbjct: 250  IQSLDQKLRVKVYDRD------------LTTSDFMGSAFVILSDLELNRTTEHILKLEDP 297

Query: 1335 KSAVS--GAIRLKINVEIK 1351
             S     G I L +N+ +K
Sbjct: 298  NSLEDDMGVIVLNLNLVVK 316



 Score = 40.8 bits (94), Expect = 0.015
 Identities = 29/107 (27%), Positives = 56/107 (52%), Gaps = 23/107 (21%)

Query: 1218 WSAKITITVVSAQGLQAKDKTGSS--DPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFEC 1275
            W+  I+IT+     L+ K+ +G S  + +V +++G  + ++KT+  + NP W E+F F  
Sbjct: 354  WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406

Query: 1276 HNSTDR---IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTL 1319
            H  +DR   + + VW +D+           K+ ++ LG   V++  L
Sbjct: 407  HYFSDRMGILDIEVWGKDN-----------KKHEERLGTCKVDISAL 442


>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
            sapiens]
          Length = 306

 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 36/127 (28%), Positives = 68/127 (53%), Gaps = 11/127 (8%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDR 1281
            + + V+ A  L A D +G SDP+  +++G ++ +T T++ NLNP W++ F F   +  D 
Sbjct: 99   LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 158

Query: 1282 IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGA 1341
            ++V V+DED D           +  DFLG+  + + ++       Y L+ +  + A  G 
Sbjct: 159  LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 207

Query: 1342 IRLKINV 1348
            I L++++
Sbjct: 208  IYLEMDL 214


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 88/423 (20%), Positives = 161/423 (38%), Gaps = 13/423 (3%)

Query: 450  DDSDEDLESDLNRNSYAVLSKSELLTKGSTSKPSSKSHSARSKNKTANSSRISNKSDY-- 507
            D SD D +SD + ++ +  S +   +  S S  SS S  +   + +++SS  SN SD   
Sbjct: 632  DSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSD 691

Query: 508  DKISSQLPESDILEKQTTTHYADATPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSEN 567
               SS   ES      + +  +D++   +S S    +  S   SD      S S D S++
Sbjct: 692  SSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSD-----SSNSSDSSDS 746

Query: 568  QFFTRTNGSSLLSSSDRELWQRKQEGTATLYDSPKDQHLNGGVQGIQGQTETENTETVDS 627
               + ++ SS  S S           ++   DS      N           + ++++ +S
Sbjct: 747  SDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNS 806

Query: 628  GMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQGADLGLDSSTQEGFDYETNSLFDQQ 687
              S+     S D S    S  S   + S   + +  +D    S + +G D ++++  D  
Sbjct: 807  SDSSD----SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSS 862

Query: 688  LDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYDSYQGANSN 747
                + D        SD  D S+S + +   +SS      +          DS   +NS+
Sbjct: 863  NSSDSSDSSDSSN-SSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS 921

Query: 748  ELYQNQNQLSMMYRSQSELQSDDSEDA-PPKSWHSRLSIDLSDKTFSFPKFGSTLQRAKS 806
            +  ++ N       S S   SD S+ +    S  S  S D S+ + S     S    + +
Sbjct: 922  DSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSN 981

Query: 807  ALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDSDVYTEPYYYKAEDEED 866
            + +   +  +   S   DS +S      + S  ++N S ++  SD         + D  D
Sbjct: 982  SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041

Query: 867  YTE 869
             ++
Sbjct: 1042 SSD 1044



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 92/402 (22%), Positives = 146/402 (36%), Gaps = 19/402 (4%)

Query: 450 DDSDEDLESDLNRNSYAVLSKSELLTKGSTSKPSSKSHSARSKNKTANSSRISNKSDYDK 509
           +D D D  SD N +       +     G+     S S   +S +  ++SS  SN SD   
Sbjct: 511 EDDDSDSTSDTNNSD-----SNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSD--- 562

Query: 510 ISSQLPESDILEKQTTTHYADATPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSENQF 569
            SS   +SD  +  +++    +       SD  ++  S S         S S D S++  
Sbjct: 563 -SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 621

Query: 570 FTRTNGSSLLSSSDRELWQRKQEGTATLYDSPKDQHLNGGVQGIQGQTETENTETVDSGM 629
               +  S   SSD +   +     +   DS  +   +           ++++++ DS  
Sbjct: 622 SKSDSSKSESDSSDSD--SKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSS 679

Query: 630 SNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQGADLGLDSSTQEGFDYETNSLFDQQLD 689
           S+     S D S  SDS  S     S     +  +D   DSS     D ++++  D    
Sbjct: 680 SSDS-SNSSDSSDSSDSSNSSESSDSSDSSDSDSSD-SSDSSNSNSSDSDSSNSSDSSDS 737

Query: 690 VYNKDLEYLGKCHSDLQDDSESYDLTQDDNSS-PCPGLDNEPQGQWVGQYDSYQGANSNE 748
             + D        SD  + S+S D +   NSS      D+          DS   +NS++
Sbjct: 738 SNSSD----SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSD 793

Query: 749 LYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKTFSFPKFGSTLQRAKSAL 808
              + N       S S   SD S+     S  S  S D SD + S     S+     S  
Sbjct: 794 SSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS 853

Query: 809 EVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDS 850
           +   N+S  S S      S       +   S +NESS + DS
Sbjct: 854 DSS-NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDS 894



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 89/412 (21%), Positives = 148/412 (35%), Gaps = 19/412 (4%)

Query: 444 NNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGST-----SKPSSKSHSARSKNKTANS 498
           N+  S D SD D  SD N +S +  S S+      +     S  S  S S+ S + + +S
Sbjct: 559 NSSDSSDSSDSD-SSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSS 617

Query: 499 SRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSDFFTAKLSRSESDFSKLCQ 558
               +KSD  K  S   +SD     + ++ +D++      SD   +  S + SD S    
Sbjct: 618 DSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS----DNSDSSDSSNSSNSSDSSDSSD 673

Query: 559 SYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDSPKDQHLNGGVQGIQGQTE 618
           S     S +   +  +  S  SS+  E         +   DS    + N         ++
Sbjct: 674 SSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSN------SSDSD 727

Query: 619 TENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQGADLGLDSSTQEGFDY 678
           + N+       ++     S D S+ SDS  S   D S   + +  +D    S +    D 
Sbjct: 728 SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS--SDSSNSSDSSDSSDSSDSSDSSNSSDS 785

Query: 679 ETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQY 738
             +S      D  N          SD  D S+S      D+S+     D+          
Sbjct: 786 NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS 845

Query: 739 DSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKTFSFPKFG 798
           DS  G++S+   ++ +  S      S+  +         S  S  S D SD + S     
Sbjct: 846 DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDS 905

Query: 799 STLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDS 850
           S    +  + +   N S  S S      S+      +   S +++SS + DS
Sbjct: 906 SDSSNSSDSSDSS-NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDS 956



 Score = 58.2 bits (139), Expect = 9e-08
 Identities = 97/420 (23%), Positives = 157/420 (37%), Gaps = 24/420 (5%)

Query: 444  NNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTSKPSSKSHSARSKNKTANSSRISN 503
            N+  S D SD    SD + +S +  S S   +  S S  SS S  +   + +++SS  S+
Sbjct: 751  NSSDSSDSSDSSNSSDSSDSSDS--SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSD 808

Query: 504  KSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSDFFTAKLSR-SESDFSKLCQSY-S 561
             SD    SS   +SD      +++ +D++   +S     ++  S  S+SD S    S  S
Sbjct: 809  SSD----SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNS 864

Query: 562  EDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDSPKD----------QHLNGGVQ 611
             D S++     +N S    SSD        + + +   S  D             +    
Sbjct: 865  SDSSDSS--DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSD 922

Query: 612  GIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQGADLGLDSS 671
              +    ++N+ + DS  S+     S D S+ SDS  S     S     +  +D    S+
Sbjct: 923  SSESSNSSDNSNSSDSSNSSDS-SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSN 981

Query: 672  TQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNSS-PCPGLDNEP 730
            + +  D   +S      D  N          SD  + S+S + +   NSS      D+  
Sbjct: 982  SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041

Query: 731  QGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDK 790
                    DS   +NS++   + +       S S   SD SE +   S  S  S D SD 
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS--DSSDSSNSSDSSDS 1099

Query: 791  TFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDS 850
            + S     S+     S      N S  S S      S       +   S +++SS + DS
Sbjct: 1100 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDS 1159



 Score = 38.9 bits (89), Expect = 0.057
 Identities = 109/584 (18%), Positives = 193/584 (33%), Gaps = 33/584 (5%)

Query: 70   SSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQELSSIESSYSE 129
            +S+ +  + +   S + S S   S     +N    N    +SD+ D     SS  S+ S+
Sbjct: 751  NSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD--SSNSSDSSNSSD 808

Query: 130  SLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGALRKLRKWKK 189
            S +   SS  + + S+ +     N   SS  + S  SSD   +  G    +  +      
Sbjct: 809  SSDSSDSSDSDSSNSSDSS----NSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNS 864

Query: 190  SQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTHDVMEMIFKE 249
            S    SSDS  S         S S D +  N  +N+ +   SS+   S + D        
Sbjct: 865  SDSSDSSDSSNS---------SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915

Query: 250  LQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRRETRDIHDYI 309
                S   +E S    + N+   S    SS      +  +   +    +  ++ D +   
Sbjct: 916  DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSD 975

Query: 310  KHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFAQRIGHQRDC 369
                   S +S    + + +  +  +S       D    SD+ N+     +    +  D 
Sbjct: 976  SSDSSNSSDSS--DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDS 1033

Query: 370  PNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKGIPSSQTYES 429
             ++         ++    DS               S    + D  +  +    S  +  S
Sbjct: 1034 SDSSDSS-----DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088

Query: 430  MAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTSKPSSKSHSA 489
             +   S        ++     DS +  +S  + NS    S S   +  S S  SS S  +
Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS----SDSSDSSDSSDSSDSSNSSDS 1144

Query: 490  RSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSDFFTAKLSRS 549
               +++++SS  S+ SD    S     SD  +   ++  +D+       SD   +  S  
Sbjct: 1145 SDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS-------SDSSDSSDSSD 1197

Query: 550  ESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDSPKDQHLNGG 609
             SD S    S     S +   +  +  S  SS   E         ++   +  D   +  
Sbjct: 1198 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSD 1257

Query: 610  VQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHED 653
                   +  E+     SG  N     S   S  SDS  S  +D
Sbjct: 1258 SSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301



 Score = 32.7 bits (73), Expect = 4.1
 Identities = 53/252 (21%), Positives = 92/252 (36%), Gaps = 29/252 (11%)

Query: 599 DSPKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWK 658
           D  KD   NG     +G  + ++  T D+  S+    ++G+ ++ +D             
Sbjct: 496 DESKD---NGNGSDSKGAEDDDSDSTSDTNNSD----SNGNGNNGNDD------------ 536

Query: 659 EWNQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDD 718
             N  +D G   S     D   +S      D  + D             DS+S D +  D
Sbjct: 537 --NDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSD 594

Query: 719 NSSPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKS 778
           +S      D+          DS   ++S    ++ +  S    S S+ +SD S+     S
Sbjct: 595 SSDSSNSSDSSDSSDSSDSSDSSDSSDS----KSDSSKSESDSSDSDSKSDSSDSNSSDS 650

Query: 779 WHSRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQ 838
             +  S D S+ + S     S+     S+     + S+ S    + S SS        S 
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSS----SDSSNSSDSSDSSDSSNSSESSDSSD 706

Query: 839 STANESSTTLDS 850
           S+ ++SS + DS
Sbjct: 707 SSDSDSSDSSDS 718


>gi|21361472 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 50/140 (35%), Positives = 70/140 (50%), Gaps = 26/140 (18%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQV---GKNKR----RTKTIFGNLNPVWDEKFYFE 1274
            + + VVS   L  KD  G+SDPYV + +    +N+     +TKTI   LNP W+E+FYF 
Sbjct: 22   LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 81

Query: 1275 CHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGE---MDVWYN--- 1328
             + S  R+   V+DE+           +   DDFLGQ  V +  L  E   M+  Y    
Sbjct: 82   VNPSNHRLLFEVFDEN-----------RLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD 130

Query: 1329 --LEKRTDKSAVSGAIRLKI 1346
              L  R+ KS V G +RLK+
Sbjct: 131  FLLRPRSHKSRVKGFLRLKM 150


>gi|222352090 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 50/140 (35%), Positives = 70/140 (50%), Gaps = 26/140 (18%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQV---GKNKR----RTKTIFGNLNPVWDEKFYFE 1274
            + + VVS   L  KD  G+SDPYV + +    +N+     +TKTI   LNP W+E+FYF 
Sbjct: 14   LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 73

Query: 1275 CHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGE---MDVWYN--- 1328
             + S  R+   V+DE+           +   DDFLGQ  V +  L  E   M+  Y    
Sbjct: 74   VNPSNHRLLFEVFDEN-----------RLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD 122

Query: 1329 --LEKRTDKSAVSGAIRLKI 1346
              L  R+ KS V G +RLK+
Sbjct: 123  FLLRPRSHKSRVKGFLRLKM 142


>gi|222352088 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 50/140 (35%), Positives = 70/140 (50%), Gaps = 26/140 (18%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQV---GKNKR----RTKTIFGNLNPVWDEKFYFE 1274
            + + VVS   L  KD  G+SDPYV + +    +N+     +TKTI   LNP W+E+FYF 
Sbjct: 14   LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 73

Query: 1275 CHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGE---MDVWYN--- 1328
             + S  R+   V+DE+           +   DDFLGQ  V +  L  E   M+  Y    
Sbjct: 74   VNPSNHRLLFEVFDEN-----------RLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD 122

Query: 1329 --LEKRTDKSAVSGAIRLKI 1346
              L  R+ KS V G +RLK+
Sbjct: 123  FLLRPRSHKSRVKGFLRLKM 142


>gi|222352086 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 50/140 (35%), Positives = 70/140 (50%), Gaps = 26/140 (18%)

Query: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQV---GKNKR----RTKTIFGNLNPVWDEKFYFE 1274
            + + VVS   L  KD  G+SDPYV + +    +N+     +TKTI   LNP W+E+FYF 
Sbjct: 22   LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 81

Query: 1275 CHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGE---MDVWYN--- 1328
             + S  R+   V+DE+           +   DDFLGQ  V +  L  E   M+  Y    
Sbjct: 82   VNPSNHRLLFEVFDEN-----------RLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD 130

Query: 1329 --LEKRTDKSAVSGAIRLKI 1346
              L  R+ KS V G +RLK+
Sbjct: 131  FLLRPRSHKSRVKGFLRLKM 150


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,142,847
Number of Sequences: 37866
Number of extensions: 3499390
Number of successful extensions: 10591
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 150
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 9644
Number of HSP's gapped (non-prelim): 1069
length of query: 2214
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2096
effective length of database: 13,779,330
effective search space: 28881475680
effective search space used: 28881475680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.