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Search of human proteins with 122937480
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937480 Ras association (RalGDS/AF-6) domain family
(N-terminal) member 10 [Homo sapiens]
(615 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937480 Ras association (RalGDS/AF-6) domain family (N-term... 1236 0.0
gi|114155158 Ras association (RalGDS/AF-6) domain family (N-term... 238 9e-63
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 52 2e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 50 5e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 50 5e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 50 5e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 50 5e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 50 5e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 50 5e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 50 5e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 50 5e-06
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap... 48 3e-05
gi|221139761 zinc finger protein 853 [Homo sapiens] 45 2e-04
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 43 0.001
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 42 0.002
gi|91208420 bassoon protein [Homo sapiens] 41 0.004
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 40 0.005
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 40 0.005
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 40 0.005
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 40 0.005
gi|32698688 citron [Homo sapiens] 40 0.005
gi|46249351 homer 2 isoform 2 [Homo sapiens] 40 0.005
gi|46249349 homer 2 isoform 1 [Homo sapiens] 40 0.005
gi|38348729 hypothetical protein LOC203238 [Homo sapiens] 40 0.005
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 40 0.006
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 40 0.006
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 40 0.006
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 40 0.006
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 40 0.006
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 40 0.006
>gi|122937480 Ras association (RalGDS/AF-6) domain family
(N-terminal) member 10 [Homo sapiens]
Length = 615
Score = 1236 bits (3197), Expect = 0.0
Identities = 615/615 (100%), Positives = 615/615 (100%)
Query: 1 MRARGGQGARGAARLRGAGLGPEPPALPATALGLGGGKGWSHVGRSKTRRSRAPWAEPER 60
MRARGGQGARGAARLRGAGLGPEPPALPATALGLGGGKGWSHVGRSKTRRSRAPWAEPER
Sbjct: 1 MRARGGQGARGAARLRGAGLGPEPPALPATALGLGGGKGWSHVGRSKTRRSRAPWAEPER 60
Query: 61 REPVLGALPRERPSSGQSAAATATTAAVAFQPAFADPGRTCHLRPGCAMDPSEKKISVWI 120
REPVLGALPRERPSSGQSAAATATTAAVAFQPAFADPGRTCHLRPGCAMDPSEKKISVWI
Sbjct: 61 REPVLGALPRERPSSGQSAAATATTAAVAFQPAFADPGRTCHLRPGCAMDPSEKKISVWI 120
Query: 121 CQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDD 180
CQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDD
Sbjct: 121 CQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDD 180
Query: 181 EDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSE 240
EDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSE
Sbjct: 181 EDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSE 240
Query: 241 ASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQ 300
ASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQ
Sbjct: 241 ASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQ 300
Query: 301 QQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRLHELDRE 360
QQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRLHELDRE
Sbjct: 301 QQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRLHELDRE 360
Query: 361 IDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAG 420
IDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAG
Sbjct: 361 IDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAG 420
Query: 421 EAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEP 480
EAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEP
Sbjct: 421 EAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEP 480
Query: 481 LEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGL 540
LEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGL
Sbjct: 481 LEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGL 540
Query: 541 LQTLHTLELTVAPDGAPGSGSPSREPGPQACADMWVDQARGLAKSGPGNDEDSDTGLSSM 600
LQTLHTLELTVAPDGAPGSGSPSREPGPQACADMWVDQARGLAKSGPGNDEDSDTGLSSM
Sbjct: 541 LQTLHTLELTVAPDGAPGSGSPSREPGPQACADMWVDQARGLAKSGPGNDEDSDTGLSSM 600
Query: 601 HSQDSDSLPMCESLV 615
HSQDSDSLPMCESLV
Sbjct: 601 HSQDSDSLPMCESLV 615
>gi|114155158 Ras association (RalGDS/AF-6) domain family
(N-terminal) member 9 [Homo sapiens]
Length = 435
Score = 238 bits (608), Expect = 9e-63
Identities = 171/500 (34%), Positives = 257/500 (51%), Gaps = 97/500 (19%)
Query: 109 MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHG 168
MD EK+I VW+CQEEKLV GL++RTT +DV++ LLE+ +R
Sbjct: 22 MDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEHEATFGEKR------------- 68
Query: 169 PGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEE 228
L G P YCI+EKWRG ER+LP TRIL+LW AWG+E
Sbjct: 69 ----------------------FLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDE 106
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
Q N++FVLV+++A LP R+AEA++V + E+ +PA + +KQ+R+VRK
Sbjct: 107 QPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKLWEL--SPANYMKTLPPDKQKRIVRKT 164
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
FRKLAK+ +Q T S H+ + METLVHL++SQDHTI
Sbjct: 165 FRKLAKI----KQDTVS-------------------HDR---DNMETLVHLIISQDHTIH 198
Query: 349 QQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAE 408
QQV+R+ ELD EI+ EAK HLDR+ G NYVQD YL+ + E++ + + +
Sbjct: 199 QQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSFSEVE--------QNLDLQ 250
Query: 409 AEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMR 468
EE LE+L+ D + +L+E+ L+++LSAEI++E+ +
Sbjct: 251 YEE------------NQTLEDLS-ESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCID 297
Query: 469 RRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQ 528
++ LE E V+ L S+ GL++++ L ++ ++ YS
Sbjct: 298 INEDAEGEAASELESS---------NLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDS 348
Query: 529 QWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPG-PQACADMWVDQARGLAKSGP 587
K +E + L + ++L ++ DG + ++E P + ++ R S
Sbjct: 349 LLQMKAKEYELLAKEFNSLHIS-NKDGCQLKENRAKESEVPSSNGEIPPFTQR--VFSNY 405
Query: 588 GNDEDSDTGLSSMHSQDSDS 607
ND DSDTG+SS HSQDS++
Sbjct: 406 TNDTDSDTGISSNHSQDSET 425
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 51.6 bits (122), Expect = 2e-06
Identities = 55/231 (23%), Positives = 89/231 (38%), Gaps = 10/231 (4%)
Query: 320 SSPRTHESASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVN 379
+S + A ER +L+ L ++++Q +R L E L+ R +
Sbjct: 1676 NSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEE-------ELLEATERINLF 1728
Query: 380 YVQDTYLVGAG--IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDL 437
Y Q+T L+ +E D +R +E EEV E + A A A EEL ++ D +
Sbjct: 1729 YTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTI 1788
Query: 438 LRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQER 497
L+ R E+ + L + E M R++ E +G +GE+ E
Sbjct: 1789 AHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEA 1848
Query: 498 VRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLE 548
R I L E K +L Q Q D + ++Q Q + E
Sbjct: 1849 QRGARRLERCI-KELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAE 1898
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/319 (21%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 238 RSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKL--AKL 295
R + + R +A V L+ A A + E+ R +A R+L A++
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 296 NRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRL- 354
R RQ Q + S+ + ++A +ER H+ ++Q +R++ +R
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---LREEAERRA 1614
Query: 355 ----------HELDREIDHYEAKVHLD-RMRRHGVNYVQDTYLVGAGIELDGSRPGEEPE 403
E +RE++ ++ K + R+R Q L A E ++ E
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-------KQKE 1667
Query: 404 EVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN 463
E EA A A + A +EL ++ +QR+ E+ L RL AE ++
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 464 QRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDL 523
QR + +EELA + EL E +VR ++ L R E +S
Sbjct: 1728 QRQL--LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTS 1782
Query: 524 DYSQQQWDSKKRELQGLLQ 542
+ S+Q+ +++ + L +
Sbjct: 1783 EKSKQRLEAEAGRFRELAE 1801
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 34/291 (11%)
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
+E +R V ++ EA+ G E + + +R A Q++Q + +
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA------------QKRQAQEEAER 1498
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
R+ + +R++Q +S + A + R +++ +E L + +R
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR-----ALQALEELRLQAEEAERRLR 1553
Query: 349 Q-QVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAA 407
Q +V+R ++ ++ + + + ++ + T + ++ + + EE
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRA-SFAEKTAQLERSLQEEHVAVAQLREEAER 1612
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRVQQEELLERLSAEIQEELNQR 465
A++ A A EA+ LE + ++ LRL Q + V Q++ L + AE Q+E +R
Sbjct: 1613 RAQQQAEAERAREEAERE-LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 466 WMRRR--QEELAAREEPLE----------PDGGPDGELLLEQERVRTQLST 504
RRR EE A R+ L +G L EQE +R + T
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722
Score = 40.8 bits (94), Expect = 0.004
Identities = 74/373 (19%), Positives = 137/373 (36%), Gaps = 57/373 (15%)
Query: 228 EQENVRFVLVRSEASLPN-AGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVR 286
+QE +R EA A + EARV RE R L + E+Q +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 287 KAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHT 346
+A KL + +Q+ + + A + + A +E+ + L Q
Sbjct: 2130 QAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 347 IRQQVQRL--------HE---LDREIDHYEAKVHLDRMRRHGVN--------YVQDTYLV 387
+ Q++ L H+ LD E+ +A+ +R V +++ +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 388 GAGIELDG---------------SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELAR 432
A IE + E+ ++VA EA + A A + A E+LA+
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 433 RCDDLLRLQEQRVQQEELLERLSAEI-----QEELNQRWMRRRQ-----------EELAA 476
+ ++ ++++Q + RL AE Q+EL Q RR Q EE
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 477 REEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRE 536
+ LE + E+ E ER++ +++ R D + + + ++ +
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 537 LQGLLQTLHTLEL 549
Q + + TLE+
Sbjct: 2424 TQEKVTLVQTLEI 2436
Score = 37.7 bits (86), Expect = 0.031
Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 29/318 (9%)
Query: 228 EQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRK 287
++ V ++ +AS A AE + L R R + A +L ++ + R+
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIR------SNAEDTLRSKEQAELEAARQ 1972
Query: 288 AFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVH----LVLSQ 343
R+LA RR+++ S A ++ R VER++ V L
Sbjct: 1973 --RQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 344 DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSR-PGEEP 402
+ +Q+Q E ++ E K H +++ +Q T + LD R E
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-LQQTLQQEQSV-LDQLRGEAEAA 2086
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
A EAEEA + E +AA + L + E++ Q + + ++++E
Sbjct: 2087 RRAAEEAEEAR----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 463 NQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSD 522
Q RR Q E AA + D E E+ + +L ++ +L ++
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADA--------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 523 LDYSQQQWDSKKRELQGL 540
L+ + Q + ELQ L
Sbjct: 2195 LEETDHQKNLLDEELQRL 2212
Score = 37.0 bits (84), Expect = 0.054
Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 30/241 (12%)
Query: 279 EKQRRVVRKAFRKLAKLN---RRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
E+QR++ A + KL R Q + A E A+ E++
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 336 LVHLVLSQ---DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIE 392
+ L + + DH + + + EL+RE + + + L +++ + VQ L+
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 393 LDGSRPGEEPEEVAAEA---EEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ-- 447
L S E+ + E +E A L + A A + LR ++QR QQ
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ---------LREEQQRQQQQM 2541
Query: 448 EELLERLSAEIQEELN-----QRWMRRRQEELAAREEPLEPDGGPDGELLLEQ-ERVRTQ 501
E+ +RL A ++E + +RR+QEEL + LE ELL E+ +R+R Q
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEEL----QQLEQQRRQQEELLAEENQRLREQ 2597
Query: 502 L 502
L
Sbjct: 2598 L 2598
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 401 EPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQE 460
+ +++ E + A+ A Q A E + R+ ++L +L++QR QQEELL + ++E
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596
Query: 461 ELNQRWMRRRQEELAAREE 479
+L Q + + LA EE
Sbjct: 2597 QL-QLLEEQHRAALAHSEE 2614
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 21/238 (8%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASV 330
R + A TQ++Q +LAK+ + S + S ++S S R A
Sbjct: 1741 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG- 1794
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
R L ++ + ++ +R +L E D + +R+ + + + +
Sbjct: 1795 -RFRELAEEA-ARLRALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 391 IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELA--RRCDDLLRLQEQRVQQE 448
E+ E E + AE+ A Q LEE A + D RL + R +
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAF--------QRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 449 ELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
LER +++ L QR R+ +EE+ A + E EL LE R+R+ +L
Sbjct: 1904 SELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 13/140 (9%)
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWM 467
E EE A A E + A E A + +L E Q + ER + E+Q+ + + +
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAA--LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 468 RR-------RQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVK 520
RR +Q++ + +EE + + E+ Q + R Q + LR+ ++ V+
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKAR-QAEAAERSRLRIEEEIRVVR 1458
Query: 521 SDLDYSQQQWDSKKRELQGL 540
L+ +++Q + ELQ L
Sbjct: 1459 LQLEATERQRGGAEGELQAL 1478
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 13/98 (13%)
Query: 407 AEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERL----SAEIQEEL 462
A A+ A A A E Q EE+ RR + + Q+Q+ +E L++L AEIQ +
Sbjct: 1378 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437
Query: 463 NQ-----RWMRRRQEELAAREEPLEPD----GGPDGEL 491
Q R R +EE+ LE GG +GEL
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/319 (21%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 238 RSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKL--AKL 295
R + + R +A V L+ A A + E+ R +A R+L A++
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1561
Query: 296 NRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRL- 354
R RQ Q + S+ + ++A +ER H+ ++Q +R++ +R
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---LREEAERRA 1618
Query: 355 ----------HELDREIDHYEAKVHLD-RMRRHGVNYVQDTYLVGAGIELDGSRPGEEPE 403
E +RE++ ++ K + R+R Q L A E ++ E
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-------KQKE 1671
Query: 404 EVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN 463
E EA A A + A +EL ++ +QR+ E+ L RL AE ++
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731
Query: 464 QRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDL 523
QR + +EELA + EL E +VR ++ L R E +S
Sbjct: 1732 QRQL--LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTS 1786
Query: 524 DYSQQQWDSKKRELQGLLQ 542
+ S+Q+ +++ + L +
Sbjct: 1787 EKSKQRLEAEAGRFRELAE 1805
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 34/291 (11%)
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
+E +R V ++ EA+ G E + + +R A Q++Q + +
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA------------QKRQAQEEAER 1502
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
R+ + +R++Q +S + A + R +++ +E L + +R
Sbjct: 1503 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR-----ALQALEELRLQAEEAERRLR 1557
Query: 349 Q-QVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAA 407
Q +V+R ++ ++ + + + ++ + T + ++ + + EE
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRA-SFAEKTAQLERSLQEEHVAVAQLREEAER 1616
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRVQQEELLERLSAEIQEELNQR 465
A++ A A EA+ LE + ++ LRL Q + V Q++ L + AE Q+E +R
Sbjct: 1617 RAQQQAEAERAREEAERE-LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 466 WMRRR--QEELAAREEPLE----------PDGGPDGELLLEQERVRTQLST 504
RRR EE A R+ L +G L EQE +R + T
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1726
Score = 40.8 bits (94), Expect = 0.004
Identities = 74/373 (19%), Positives = 137/373 (36%), Gaps = 57/373 (15%)
Query: 228 EQENVRFVLVRSEASLPN-AGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVR 286
+QE +R EA A + EARV RE R L + E+Q +
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133
Query: 287 KAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHT 346
+A KL + +Q+ + + A + + A +E+ + L Q
Sbjct: 2134 QAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2187
Query: 347 IRQQVQRL--------HE---LDREIDHYEAKVHLDRMRRHGVN--------YVQDTYLV 387
+ Q++ L H+ LD E+ +A+ +R V +++ +
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2247
Query: 388 GAGIELDG---------------SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELAR 432
A IE + E+ ++VA EA + A A + A E+LA+
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307
Query: 433 RCDDLLRLQEQRVQQEELLERLSAEI-----QEELNQRWMRRRQ-----------EELAA 476
+ ++ ++++Q + RL AE Q+EL Q RR Q EE
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367
Query: 477 REEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRE 536
+ LE + E+ E ER++ +++ R D + + + ++ +
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 537 LQGLLQTLHTLEL 549
Q + + TLE+
Sbjct: 2428 TQEKVTLVQTLEI 2440
Score = 37.7 bits (86), Expect = 0.031
Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 29/318 (9%)
Query: 228 EQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRK 287
++ V ++ +AS A AE + L R R + A +L ++ + R+
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAELELELGRIR------SNAEDTLRSKEQAELEAARQ 1976
Query: 288 AFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVH----LVLSQ 343
R+LA RR+++ S A ++ R VER++ V L
Sbjct: 1977 --RQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2032
Query: 344 DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSR-PGEEP 402
+ +Q+Q E ++ E K H +++ +Q T + LD R E
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-LQQTLQQEQSV-LDQLRGEAEAA 2090
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
A EAEEA + E +AA + L + E++ Q + + ++++E
Sbjct: 2091 RRAAEEAEEAR----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2146
Query: 463 NQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSD 522
Q RR Q E AA + D E E+ + +L ++ +L ++
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADA--------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2198
Query: 523 LDYSQQQWDSKKRELQGL 540
L+ + Q + ELQ L
Sbjct: 2199 LEETDHQKNLLDEELQRL 2216
Score = 37.0 bits (84), Expect = 0.054
Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 30/241 (12%)
Query: 279 EKQRRVVRKAFRKLAKLN---RRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
E+QR++ A + KL R Q + A E A+ E++
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 336 LVHLVLSQ---DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIE 392
+ L + + DH + + + EL+RE + + + L +++ + VQ L+
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 393 LDGSRPGEEPEEVAAEA---EEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ-- 447
L S E+ + E +E A L + A A + LR ++QR QQ
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ---------LREEQQRQQQQM 2545
Query: 448 EELLERLSAEIQEELN-----QRWMRRRQEELAAREEPLEPDGGPDGELLLEQ-ERVRTQ 501
E+ +RL A ++E + +RR+QEEL + LE ELL E+ +R+R Q
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEEL----QQLEQQRRQQEELLAEENQRLREQ 2601
Query: 502 L 502
L
Sbjct: 2602 L 2602
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 401 EPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQE 460
+ +++ E + A+ A Q A E + R+ ++L +L++QR QQEELL + ++E
Sbjct: 2541 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2600
Query: 461 ELNQRWMRRRQEELAAREE 479
+L Q + + LA EE
Sbjct: 2601 QL-QLLEEQHRAALAHSEE 2618
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 21/238 (8%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASV 330
R + A TQ++Q +LAK+ + S + S ++S S R A
Sbjct: 1745 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG- 1798
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
R L ++ + ++ +R +L E D + +R+ + + + +
Sbjct: 1799 -RFRELAEEA-ARLRALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKTE 1855
Query: 391 IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELA--RRCDDLLRLQEQRVQQE 448
E+ E E + AE+ A Q LEE A + D RL + R +
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAF--------QRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 449 ELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
LER +++ L QR R+ +EE+ A + E EL LE R+R+ +L
Sbjct: 1908 SELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 13/140 (9%)
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWM 467
E EE A A E + A E A + +L E Q + ER + E+Q+ + + +
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAA--LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 468 RR-------RQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVK 520
RR +Q++ + +EE + + E+ Q + R Q + LR+ ++ V+
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKAR-QAEAAERSRLRIEEEIRVVR 1462
Query: 521 SDLDYSQQQWDSKKRELQGL 540
L+ +++Q + ELQ L
Sbjct: 1463 LQLEATERQRGGAEGELQAL 1482
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 13/98 (13%)
Query: 407 AEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERL----SAEIQEEL 462
A A+ A A A E Q EE+ RR + + Q+Q+ +E L++L AEIQ +
Sbjct: 1382 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1441
Query: 463 NQ-----RWMRRRQEELAAREEPLEPD----GGPDGEL 491
Q R R +EE+ LE GG +GEL
Sbjct: 1442 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/319 (21%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 238 RSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKL--AKL 295
R + + R +A V L+ A A + E+ R +A R+L A++
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 296 NRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRL- 354
R RQ Q + S+ + ++A +ER H+ ++Q +R++ +R
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---LREEAERRA 1614
Query: 355 ----------HELDREIDHYEAKVHLD-RMRRHGVNYVQDTYLVGAGIELDGSRPGEEPE 403
E +RE++ ++ K + R+R Q L A E ++ E
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-------KQKE 1667
Query: 404 EVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN 463
E EA A A + A +EL ++ +QR+ E+ L RL AE ++
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 464 QRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDL 523
QR + +EELA + EL E +VR ++ L R E +S
Sbjct: 1728 QRQL--LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTS 1782
Query: 524 DYSQQQWDSKKRELQGLLQ 542
+ S+Q+ +++ + L +
Sbjct: 1783 EKSKQRLEAEAGRFRELAE 1801
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 34/291 (11%)
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
+E +R V ++ EA+ G E + + +R A Q++Q + +
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA------------QKRQAQEEAER 1498
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
R+ + +R++Q +S + A + R +++ +E L + +R
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR-----ALQALEELRLQAEEAERRLR 1553
Query: 349 Q-QVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAA 407
Q +V+R ++ ++ + + + ++ + T + ++ + + EE
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRA-SFAEKTAQLERSLQEEHVAVAQLREEAER 1612
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRVQQEELLERLSAEIQEELNQR 465
A++ A A EA+ LE + ++ LRL Q + V Q++ L + AE Q+E +R
Sbjct: 1613 RAQQQAEAERAREEAERE-LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 466 WMRRR--QEELAAREEPLE----------PDGGPDGELLLEQERVRTQLST 504
RRR EE A R+ L +G L EQE +R + T
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722
Score = 40.8 bits (94), Expect = 0.004
Identities = 74/373 (19%), Positives = 137/373 (36%), Gaps = 57/373 (15%)
Query: 228 EQENVRFVLVRSEASLPN-AGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVR 286
+QE +R EA A + EARV RE R L + E+Q +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 287 KAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHT 346
+A KL + +Q+ + + A + + A +E+ + L Q
Sbjct: 2130 QAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 347 IRQQVQRL--------HE---LDREIDHYEAKVHLDRMRRHGVN--------YVQDTYLV 387
+ Q++ L H+ LD E+ +A+ +R V +++ +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 388 GAGIELDG---------------SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELAR 432
A IE + E+ ++VA EA + A A + A E+LA+
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 433 RCDDLLRLQEQRVQQEELLERLSAEI-----QEELNQRWMRRRQ-----------EELAA 476
+ ++ ++++Q + RL AE Q+EL Q RR Q EE
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 477 REEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRE 536
+ LE + E+ E ER++ +++ R D + + + ++ +
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 537 LQGLLQTLHTLEL 549
Q + + TLE+
Sbjct: 2424 TQEKVTLVQTLEI 2436
Score = 37.7 bits (86), Expect = 0.031
Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 29/318 (9%)
Query: 228 EQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRK 287
++ V ++ +AS A AE + L R R + A +L ++ + R+
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIR------SNAEDTLRSKEQAELEAARQ 1972
Query: 288 AFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVH----LVLSQ 343
R+LA RR+++ S A ++ R VER++ V L
Sbjct: 1973 --RQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 344 DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSR-PGEEP 402
+ +Q+Q E ++ E K H +++ +Q T + LD R E
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-LQQTLQQEQSV-LDQLRGEAEAA 2086
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
A EAEEA + E +AA + L + E++ Q + + ++++E
Sbjct: 2087 RRAAEEAEEAR----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 463 NQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSD 522
Q RR Q E AA + D E E+ + +L ++ +L ++
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADA--------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 523 LDYSQQQWDSKKRELQGL 540
L+ + Q + ELQ L
Sbjct: 2195 LEETDHQKNLLDEELQRL 2212
Score = 37.0 bits (84), Expect = 0.054
Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 30/241 (12%)
Query: 279 EKQRRVVRKAFRKLAKLN---RRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
E+QR++ A + KL R Q + A E A+ E++
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 336 LVHLVLSQ---DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIE 392
+ L + + DH + + + EL+RE + + + L +++ + VQ L+
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 393 LDGSRPGEEPEEVAAEA---EEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ-- 447
L S E+ + E +E A L + A A + LR ++QR QQ
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ---------LREEQQRQQQQM 2541
Query: 448 EELLERLSAEIQEELN-----QRWMRRRQEELAAREEPLEPDGGPDGELLLEQ-ERVRTQ 501
E+ +RL A ++E + +RR+QEEL + LE ELL E+ +R+R Q
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEEL----QQLEQQRRQQEELLAEENQRLREQ 2597
Query: 502 L 502
L
Sbjct: 2598 L 2598
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 401 EPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQE 460
+ +++ E + A+ A Q A E + R+ ++L +L++QR QQEELL + ++E
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596
Query: 461 ELNQRWMRRRQEELAAREE 479
+L Q + + LA EE
Sbjct: 2597 QL-QLLEEQHRAALAHSEE 2614
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 21/238 (8%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASV 330
R + A TQ++Q +LAK+ + S + S ++S S R A
Sbjct: 1741 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG- 1794
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
R L ++ + ++ +R +L E D + +R+ + + + +
Sbjct: 1795 -RFRELAEEA-ARLRALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 391 IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELA--RRCDDLLRLQEQRVQQE 448
E+ E E + AE+ A Q LEE A + D RL + R +
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAF--------QRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 449 ELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
LER +++ L QR R+ +EE+ A + E EL LE R+R+ +L
Sbjct: 1904 SELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 13/140 (9%)
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWM 467
E EE A A E + A E A + +L E Q + ER + E+Q+ + + +
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAA--LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 468 RR-------RQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVK 520
RR +Q++ + +EE + + E+ Q + R Q + LR+ ++ V+
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKAR-QAEAAERSRLRIEEEIRVVR 1458
Query: 521 SDLDYSQQQWDSKKRELQGL 540
L+ +++Q + ELQ L
Sbjct: 1459 LQLEATERQRGGAEGELQAL 1478
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 13/98 (13%)
Query: 407 AEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERL----SAEIQEEL 462
A A+ A A A E Q EE+ RR + + Q+Q+ +E L++L AEIQ +
Sbjct: 1378 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437
Query: 463 NQ-----RWMRRRQEELAAREEPLEPD----GGPDGEL 491
Q R R +EE+ LE GG +GEL
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/319 (21%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 238 RSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKL--AKL 295
R + + R +A V L+ A A + E+ R +A R+L A++
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1525
Query: 296 NRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRL- 354
R RQ Q + S+ + ++A +ER H+ ++Q +R++ +R
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---LREEAERRA 1582
Query: 355 ----------HELDREIDHYEAKVHLD-RMRRHGVNYVQDTYLVGAGIELDGSRPGEEPE 403
E +RE++ ++ K + R+R Q L A E ++ E
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-------KQKE 1635
Query: 404 EVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN 463
E EA A A + A +EL ++ +QR+ E+ L RL AE ++
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695
Query: 464 QRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDL 523
QR + +EELA + EL E +VR ++ L R E +S
Sbjct: 1696 QRQL--LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTS 1750
Query: 524 DYSQQQWDSKKRELQGLLQ 542
+ S+Q+ +++ + L +
Sbjct: 1751 EKSKQRLEAEAGRFRELAE 1769
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 34/291 (11%)
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
+E +R V ++ EA+ G E + + +R A Q++Q + +
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA------------QKRQAQEEAER 1466
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
R+ + +R++Q +S + A + R +++ +E L + +R
Sbjct: 1467 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR-----ALQALEELRLQAEEAERRLR 1521
Query: 349 Q-QVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAA 407
Q +V+R ++ ++ + + + ++ + T + ++ + + EE
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRA-SFAEKTAQLERSLQEEHVAVAQLREEAER 1580
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRVQQEELLERLSAEIQEELNQR 465
A++ A A EA+ LE + ++ LRL Q + V Q++ L + AE Q+E +R
Sbjct: 1581 RAQQQAEAERAREEAERE-LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 466 WMRRR--QEELAAREEPLE----------PDGGPDGELLLEQERVRTQLST 504
RRR EE A R+ L +G L EQE +R + T
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1690
Score = 40.8 bits (94), Expect = 0.004
Identities = 74/373 (19%), Positives = 137/373 (36%), Gaps = 57/373 (15%)
Query: 228 EQENVRFVLVRSEASLPN-AGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVR 286
+QE +R EA A + EARV RE R L + E+Q +
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097
Query: 287 KAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHT 346
+A KL + +Q+ + + A + + A +E+ + L Q
Sbjct: 2098 QAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2151
Query: 347 IRQQVQRL--------HE---LDREIDHYEAKVHLDRMRRHGVN--------YVQDTYLV 387
+ Q++ L H+ LD E+ +A+ +R V +++ +
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2211
Query: 388 GAGIELDG---------------SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELAR 432
A IE + E+ ++VA EA + A A + A E+LA+
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271
Query: 433 RCDDLLRLQEQRVQQEELLERLSAEI-----QEELNQRWMRRRQ-----------EELAA 476
+ ++ ++++Q + RL AE Q+EL Q RR Q EE
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331
Query: 477 REEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRE 536
+ LE + E+ E ER++ +++ R D + + + ++ +
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2391
Query: 537 LQGLLQTLHTLEL 549
Q + + TLE+
Sbjct: 2392 TQEKVTLVQTLEI 2404
Score = 37.7 bits (86), Expect = 0.031
Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 29/318 (9%)
Query: 228 EQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRK 287
++ V ++ +AS A AE + L R R + A +L ++ + R+
Sbjct: 1887 QRRQVEEEILALKASFEKAAAGKAELELELGRIR------SNAEDTLRSKEQAELEAARQ 1940
Query: 288 AFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVH----LVLSQ 343
R+LA RR+++ S A ++ R VER++ V L
Sbjct: 1941 --RQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 1996
Query: 344 DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSR-PGEEP 402
+ +Q+Q E ++ E K H +++ +Q T + LD R E
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-LQQTLQQEQSV-LDQLRGEAEAA 2054
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
A EAEEA + E +AA + L + E++ Q + + ++++E
Sbjct: 2055 RRAAEEAEEAR----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2110
Query: 463 NQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSD 522
Q RR Q E AA + D E E+ + +L ++ +L ++
Sbjct: 2111 EQEAARRAQAEQAALRQKQAADA--------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2162
Query: 523 LDYSQQQWDSKKRELQGL 540
L+ + Q + ELQ L
Sbjct: 2163 LEETDHQKNLLDEELQRL 2180
Score = 37.0 bits (84), Expect = 0.054
Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 30/241 (12%)
Query: 279 EKQRRVVRKAFRKLAKLN---RRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
E+QR++ A + KL R Q + A E A+ E++
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 336 LVHLVLSQ---DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIE 392
+ L + + DH + + + EL+RE + + + L +++ + VQ L+
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 393 LDGSRPGEEPEEVAAEA---EEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ-- 447
L S E+ + E +E A L + A A + LR ++QR QQ
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ---------LREEQQRQQQQM 2509
Query: 448 EELLERLSAEIQEELN-----QRWMRRRQEELAAREEPLEPDGGPDGELLLEQ-ERVRTQ 501
E+ +RL A ++E + +RR+QEEL + LE ELL E+ +R+R Q
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEEL----QQLEQQRRQQEELLAEENQRLREQ 2565
Query: 502 L 502
L
Sbjct: 2566 L 2566
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 401 EPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQE 460
+ +++ E + A+ A Q A E + R+ ++L +L++QR QQEELL + ++E
Sbjct: 2505 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2564
Query: 461 ELNQRWMRRRQEELAAREE 479
+L Q + + LA EE
Sbjct: 2565 QL-QLLEEQHRAALAHSEE 2582
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 21/238 (8%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASV 330
R + A TQ++Q +LAK+ + S + S ++S S R A
Sbjct: 1709 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG- 1762
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
R L ++ + ++ +R +L E D + +R+ + + + +
Sbjct: 1763 -RFRELAEEA-ARLRALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKTE 1819
Query: 391 IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELA--RRCDDLLRLQEQRVQQE 448
E+ E E + AE+ A Q LEE A + D RL + R +
Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAF--------QRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 449 ELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
LER +++ L QR R+ +EE+ A + E EL LE R+R+ +L
Sbjct: 1872 SELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 13/140 (9%)
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWM 467
E EE A A E + A E A + +L E Q + ER + E+Q+ + + +
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAA--LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 468 RR-------RQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVK 520
RR +Q++ + +EE + + E+ Q + R Q + LR+ ++ V+
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKAR-QAEAAERSRLRIEEEIRVVR 1426
Query: 521 SDLDYSQQQWDSKKRELQGL 540
L+ +++Q + ELQ L
Sbjct: 1427 LQLEATERQRGGAEGELQAL 1446
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 13/98 (13%)
Query: 407 AEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERL----SAEIQEEL 462
A A+ A A A E Q EE+ RR + + Q+Q+ +E L++L AEIQ +
Sbjct: 1346 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1405
Query: 463 NQ-----RWMRRRQEELAAREEPLEPD----GGPDGEL 491
Q R R +EE+ LE GG +GEL
Sbjct: 1406 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/319 (21%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 238 RSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKL--AKL 295
R + + R +A V L+ A A + E+ R +A R+L A++
Sbjct: 1635 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1694
Query: 296 NRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRL- 354
R RQ Q + S+ + ++A +ER H+ ++Q +R++ +R
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---LREEAERRA 1751
Query: 355 ----------HELDREIDHYEAKVHLD-RMRRHGVNYVQDTYLVGAGIELDGSRPGEEPE 403
E +RE++ ++ K + R+R Q L A E ++ E
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-------KQKE 1804
Query: 404 EVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN 463
E EA A A + A +EL ++ +QR+ E+ L RL AE ++
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864
Query: 464 QRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDL 523
QR + +EELA + EL E +VR ++ L R E +S
Sbjct: 1865 QRQL--LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTS 1919
Query: 524 DYSQQQWDSKKRELQGLLQ 542
+ S+Q+ +++ + L +
Sbjct: 1920 EKSKQRLEAEAGRFRELAE 1938
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 34/291 (11%)
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
+E +R V ++ EA+ G E + + +R A Q++Q + +
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA------------QKRQAQEEAER 1635
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
R+ + +R++Q +S + A + R +++ +E L + +R
Sbjct: 1636 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR-----ALQALEELRLQAEEAERRLR 1690
Query: 349 Q-QVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAA 407
Q +V+R ++ ++ + + + ++ + T + ++ + + EE
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRA-SFAEKTAQLERSLQEEHVAVAQLREEAER 1749
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRVQQEELLERLSAEIQEELNQR 465
A++ A A EA+ LE + ++ LRL Q + V Q++ L + AE Q+E +R
Sbjct: 1750 RAQQQAEAERAREEAERE-LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 466 WMRRR--QEELAAREEPLE----------PDGGPDGELLLEQERVRTQLST 504
RRR EE A R+ L +G L EQE +R + T
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1859
Score = 40.8 bits (94), Expect = 0.004
Identities = 74/373 (19%), Positives = 137/373 (36%), Gaps = 57/373 (15%)
Query: 228 EQENVRFVLVRSEASLPN-AGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVR 286
+QE +R EA A + EARV RE R L + E+Q +
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266
Query: 287 KAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHT 346
+A KL + +Q+ + + A + + A +E+ + L Q
Sbjct: 2267 QAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2320
Query: 347 IRQQVQRL--------HE---LDREIDHYEAKVHLDRMRRHGVN--------YVQDTYLV 387
+ Q++ L H+ LD E+ +A+ +R V +++ +
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2380
Query: 388 GAGIELDG---------------SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELAR 432
A IE + E+ ++VA EA + A A + A E+LA+
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440
Query: 433 RCDDLLRLQEQRVQQEELLERLSAEI-----QEELNQRWMRRRQ-----------EELAA 476
+ ++ ++++Q + RL AE Q+EL Q RR Q EE
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500
Query: 477 REEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRE 536
+ LE + E+ E ER++ +++ R D + + + ++ +
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2560
Query: 537 LQGLLQTLHTLEL 549
Q + + TLE+
Sbjct: 2561 TQEKVTLVQTLEI 2573
Score = 37.7 bits (86), Expect = 0.031
Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 29/318 (9%)
Query: 228 EQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRK 287
++ V ++ +AS A AE + L R R + A +L ++ + R+
Sbjct: 2056 QRRQVEEEILALKASFEKAAAGKAELELELGRIR------SNAEDTLRSKEQAELEAARQ 2109
Query: 288 AFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVH----LVLSQ 343
R+LA RR+++ S A ++ R VER++ V L
Sbjct: 2110 --RQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2165
Query: 344 DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSR-PGEEP 402
+ +Q+Q E ++ E K H +++ +Q T + LD R E
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-LQQTLQQEQSV-LDQLRGEAEAA 2223
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
A EAEEA + E +AA + L + E++ Q + + ++++E
Sbjct: 2224 RRAAEEAEEAR----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2279
Query: 463 NQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSD 522
Q RR Q E AA + D E E+ + +L ++ +L ++
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADA--------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2331
Query: 523 LDYSQQQWDSKKRELQGL 540
L+ + Q + ELQ L
Sbjct: 2332 LEETDHQKNLLDEELQRL 2349
Score = 37.0 bits (84), Expect = 0.054
Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 30/241 (12%)
Query: 279 EKQRRVVRKAFRKLAKLN---RRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
E+QR++ A + KL R Q + A E A+ E++
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567
Query: 336 LVHLVLSQ---DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIE 392
+ L + + DH + + + EL+RE + + + L +++ + VQ L+
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 393 LDGSRPGEEPEEVAAEA---EEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ-- 447
L S E+ + E +E A L + A A + LR ++QR QQ
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ---------LREEQQRQQQQM 2678
Query: 448 EELLERLSAEIQEELN-----QRWMRRRQEELAAREEPLEPDGGPDGELLLEQ-ERVRTQ 501
E+ +RL A ++E + +RR+QEEL + LE ELL E+ +R+R Q
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEEL----QQLEQQRRQQEELLAEENQRLREQ 2734
Query: 502 L 502
L
Sbjct: 2735 L 2735
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 401 EPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQE 460
+ +++ E + A+ A Q A E + R+ ++L +L++QR QQEELL + ++E
Sbjct: 2674 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2733
Query: 461 ELNQRWMRRRQEELAAREE 479
+L Q + + LA EE
Sbjct: 2734 QL-QLLEEQHRAALAHSEE 2751
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 21/238 (8%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASV 330
R + A TQ++Q +LAK+ + S + S ++S S R A
Sbjct: 1878 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG- 1931
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
R L ++ + ++ +R +L E D + +R+ + + + +
Sbjct: 1932 -RFRELAEEA-ARLRALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKTE 1988
Query: 391 IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELA--RRCDDLLRLQEQRVQQE 448
E+ E E + AE+ A Q LEE A + D RL + R +
Sbjct: 1989 AEIALKEKEAENERLRRLAEDEAF--------QRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 449 ELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
LER +++ L QR R+ +EE+ A + E EL LE R+R+ +L
Sbjct: 2041 SELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 13/140 (9%)
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWM 467
E EE A A E + A E A + +L E Q + ER + E+Q+ + + +
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAA--LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 468 RR-------RQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVK 520
RR +Q++ + +EE + + E+ Q + R Q + LR+ ++ V+
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKAR-QAEAAERSRLRIEEEIRVVR 1595
Query: 521 SDLDYSQQQWDSKKRELQGL 540
L+ +++Q + ELQ L
Sbjct: 1596 LQLEATERQRGGAEGELQAL 1615
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 13/98 (13%)
Query: 407 AEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERL----SAEIQEEL 462
A A+ A A A E Q EE+ RR + + Q+Q+ +E L++L AEIQ +
Sbjct: 1515 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1574
Query: 463 NQ-----RWMRRRQEELAAREEPLEPD----GGPDGEL 491
Q R R +EE+ LE GG +GEL
Sbjct: 1575 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/319 (21%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 238 RSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKL--AKL 295
R + + R +A V L+ A A + E+ R +A R+L A++
Sbjct: 1476 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1535
Query: 296 NRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRL- 354
R RQ Q + S+ + ++A +ER H+ ++Q +R++ +R
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---LREEAERRA 1592
Query: 355 ----------HELDREIDHYEAKVHLD-RMRRHGVNYVQDTYLVGAGIELDGSRPGEEPE 403
E +RE++ ++ K + R+R Q L A E ++ E
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-------KQKE 1645
Query: 404 EVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN 463
E EA A A + A +EL ++ +QR+ E+ L RL AE ++
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705
Query: 464 QRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDL 523
QR + +EELA + EL E +VR ++ L R E +S
Sbjct: 1706 QRQL--LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTS 1760
Query: 524 DYSQQQWDSKKRELQGLLQ 542
+ S+Q+ +++ + L +
Sbjct: 1761 EKSKQRLEAEAGRFRELAE 1779
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 34/291 (11%)
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
+E +R V ++ EA+ G E + + +R A Q++Q + +
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA------------QKRQAQEEAER 1476
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
R+ + +R++Q +S + A + R +++ +E L + +R
Sbjct: 1477 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR-----ALQALEELRLQAEEAERRLR 1531
Query: 349 Q-QVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAA 407
Q +V+R ++ ++ + + + ++ + T + ++ + + EE
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRA-SFAEKTAQLERSLQEEHVAVAQLREEAER 1590
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRVQQEELLERLSAEIQEELNQR 465
A++ A A EA+ LE + ++ LRL Q + V Q++ L + AE Q+E +R
Sbjct: 1591 RAQQQAEAERAREEAERE-LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 466 WMRRR--QEELAAREEPLE----------PDGGPDGELLLEQERVRTQLST 504
RRR EE A R+ L +G L EQE +R + T
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1700
Score = 40.8 bits (94), Expect = 0.004
Identities = 74/373 (19%), Positives = 137/373 (36%), Gaps = 57/373 (15%)
Query: 228 EQENVRFVLVRSEASLPN-AGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVR 286
+QE +R EA A + EARV RE R L + E+Q +
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2107
Query: 287 KAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHT 346
+A KL + +Q+ + + A + + A +E+ + L Q
Sbjct: 2108 QAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2161
Query: 347 IRQQVQRL--------HE---LDREIDHYEAKVHLDRMRRHGVN--------YVQDTYLV 387
+ Q++ L H+ LD E+ +A+ +R V +++ +
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2221
Query: 388 GAGIELDG---------------SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELAR 432
A IE + E+ ++VA EA + A A + A E+LA+
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281
Query: 433 RCDDLLRLQEQRVQQEELLERLSAEI-----QEELNQRWMRRRQ-----------EELAA 476
+ ++ ++++Q + RL AE Q+EL Q RR Q EE
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341
Query: 477 REEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRE 536
+ LE + E+ E ER++ +++ R D + + + ++ +
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2401
Query: 537 LQGLLQTLHTLEL 549
Q + + TLE+
Sbjct: 2402 TQEKVTLVQTLEI 2414
Score = 37.7 bits (86), Expect = 0.031
Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 29/318 (9%)
Query: 228 EQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRK 287
++ V ++ +AS A AE + L R R + A +L ++ + R+
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRIR------SNAEDTLRSKEQAELEAARQ 1950
Query: 288 AFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVH----LVLSQ 343
R+LA RR+++ S A ++ R VER++ V L
Sbjct: 1951 --RQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2006
Query: 344 DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSR-PGEEP 402
+ +Q+Q E ++ E K H +++ +Q T + LD R E
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-LQQTLQQEQSV-LDQLRGEAEAA 2064
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
A EAEEA + E +AA + L + E++ Q + + ++++E
Sbjct: 2065 RRAAEEAEEAR----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2120
Query: 463 NQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSD 522
Q RR Q E AA + D E E+ + +L ++ +L ++
Sbjct: 2121 EQEAARRAQAEQAALRQKQAADA--------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2172
Query: 523 LDYSQQQWDSKKRELQGL 540
L+ + Q + ELQ L
Sbjct: 2173 LEETDHQKNLLDEELQRL 2190
Score = 37.0 bits (84), Expect = 0.054
Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 30/241 (12%)
Query: 279 EKQRRVVRKAFRKLAKLN---RRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
E+QR++ A + KL R Q + A E A+ E++
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2408
Query: 336 LVHLVLSQ---DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIE 392
+ L + + DH + + + EL+RE + + + L +++ + VQ L+
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 393 LDGSRPGEEPEEVAAEA---EEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ-- 447
L S E+ + E +E A L + A A + LR ++QR QQ
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ---------LREEQQRQQQQM 2519
Query: 448 EELLERLSAEIQEELN-----QRWMRRRQEELAAREEPLEPDGGPDGELLLEQ-ERVRTQ 501
E+ +RL A ++E + +RR+QEEL + LE ELL E+ +R+R Q
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEEL----QQLEQQRRQQEELLAEENQRLREQ 2575
Query: 502 L 502
L
Sbjct: 2576 L 2576
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 401 EPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQE 460
+ +++ E + A+ A Q A E + R+ ++L +L++QR QQEELL + ++E
Sbjct: 2515 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2574
Query: 461 ELNQRWMRRRQEELAAREE 479
+L Q + + LA EE
Sbjct: 2575 QL-QLLEEQHRAALAHSEE 2592
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 21/238 (8%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASV 330
R + A TQ++Q +LAK+ + S + S ++S S R A
Sbjct: 1719 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG- 1772
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
R L ++ + ++ +R +L E D + +R+ + + + +
Sbjct: 1773 -RFRELAEEA-ARLRALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKTE 1829
Query: 391 IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELA--RRCDDLLRLQEQRVQQE 448
E+ E E + AE+ A Q LEE A + D RL + R +
Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAF--------QRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 449 ELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
LER +++ L QR R+ +EE+ A + E EL LE R+R+ +L
Sbjct: 1882 SELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 13/140 (9%)
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWM 467
E EE A A E + A E A + +L E Q + ER + E+Q+ + + +
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAA--LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 468 RR-------RQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVK 520
RR +Q++ + +EE + + E+ Q + R Q + LR+ ++ V+
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKAR-QAEAAERSRLRIEEEIRVVR 1436
Query: 521 SDLDYSQQQWDSKKRELQGL 540
L+ +++Q + ELQ L
Sbjct: 1437 LQLEATERQRGGAEGELQAL 1456
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 13/98 (13%)
Query: 407 AEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERL----SAEIQEEL 462
A A+ A A A E Q EE+ RR + + Q+Q+ +E L++L AEIQ +
Sbjct: 1356 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1415
Query: 463 NQ-----RWMRRRQEELAAREEPLEPD----GGPDGEL 491
Q R R +EE+ LE GG +GEL
Sbjct: 1416 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/319 (21%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 238 RSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKL--AKL 295
R + + R +A V L+ A A + E+ R +A R+L A++
Sbjct: 1484 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1543
Query: 296 NRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRL- 354
R RQ Q + S+ + ++A +ER H+ ++Q +R++ +R
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---LREEAERRA 1600
Query: 355 ----------HELDREIDHYEAKVHLD-RMRRHGVNYVQDTYLVGAGIELDGSRPGEEPE 403
E +RE++ ++ K + R+R Q L A E ++ E
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-------KQKE 1653
Query: 404 EVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN 463
E EA A A + A +EL ++ +QR+ E+ L RL AE ++
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713
Query: 464 QRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDL 523
QR + +EELA + EL E +VR ++ L R E +S
Sbjct: 1714 QRQL--LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTS 1768
Query: 524 DYSQQQWDSKKRELQGLLQ 542
+ S+Q+ +++ + L +
Sbjct: 1769 EKSKQRLEAEAGRFRELAE 1787
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 34/291 (11%)
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
+E +R V ++ EA+ G E + + +R A Q++Q + +
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA------------QKRQAQEEAER 1484
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
R+ + +R++Q +S + A + R +++ +E L + +R
Sbjct: 1485 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR-----ALQALEELRLQAEEAERRLR 1539
Query: 349 Q-QVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAA 407
Q +V+R ++ ++ + + + ++ + T + ++ + + EE
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRA-SFAEKTAQLERSLQEEHVAVAQLREEAER 1598
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRVQQEELLERLSAEIQEELNQR 465
A++ A A EA+ LE + ++ LRL Q + V Q++ L + AE Q+E +R
Sbjct: 1599 RAQQQAEAERAREEAERE-LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 466 WMRRR--QEELAAREEPLE----------PDGGPDGELLLEQERVRTQLST 504
RRR EE A R+ L +G L EQE +R + T
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1708
Score = 40.8 bits (94), Expect = 0.004
Identities = 74/373 (19%), Positives = 137/373 (36%), Gaps = 57/373 (15%)
Query: 228 EQENVRFVLVRSEASLPN-AGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVR 286
+QE +R EA A + EARV RE R L + E+Q +
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2115
Query: 287 KAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHT 346
+A KL + +Q+ + + A + + A +E+ + L Q
Sbjct: 2116 QAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2169
Query: 347 IRQQVQRL--------HE---LDREIDHYEAKVHLDRMRRHGVN--------YVQDTYLV 387
+ Q++ L H+ LD E+ +A+ +R V +++ +
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2229
Query: 388 GAGIELDG---------------SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELAR 432
A IE + E+ ++VA EA + A A + A E+LA+
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289
Query: 433 RCDDLLRLQEQRVQQEELLERLSAEI-----QEELNQRWMRRRQ-----------EELAA 476
+ ++ ++++Q + RL AE Q+EL Q RR Q EE
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349
Query: 477 REEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRE 536
+ LE + E+ E ER++ +++ R D + + + ++ +
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2409
Query: 537 LQGLLQTLHTLEL 549
Q + + TLE+
Sbjct: 2410 TQEKVTLVQTLEI 2422
Score = 37.7 bits (86), Expect = 0.031
Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 29/318 (9%)
Query: 228 EQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRK 287
++ V ++ +AS A AE + L R R + A +L ++ + R+
Sbjct: 1905 QRRQVEEEILALKASFEKAAAGKAELELELGRIR------SNAEDTLRSKEQAELEAARQ 1958
Query: 288 AFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVH----LVLSQ 343
R+LA RR+++ S A ++ R VER++ V L
Sbjct: 1959 --RQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2014
Query: 344 DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSR-PGEEP 402
+ +Q+Q E ++ E K H +++ +Q T + LD R E
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-LQQTLQQEQSV-LDQLRGEAEAA 2072
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
A EAEEA + E +AA + L + E++ Q + + ++++E
Sbjct: 2073 RRAAEEAEEAR----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2128
Query: 463 NQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSD 522
Q RR Q E AA + D E E+ + +L ++ +L ++
Sbjct: 2129 EQEAARRAQAEQAALRQKQAADA--------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2180
Query: 523 LDYSQQQWDSKKRELQGL 540
L+ + Q + ELQ L
Sbjct: 2181 LEETDHQKNLLDEELQRL 2198
Score = 37.0 bits (84), Expect = 0.054
Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 30/241 (12%)
Query: 279 EKQRRVVRKAFRKLAKLN---RRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
E+QR++ A + KL R Q + A E A+ E++
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2416
Query: 336 LVHLVLSQ---DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIE 392
+ L + + DH + + + EL+RE + + + L +++ + VQ L+
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 393 LDGSRPGEEPEEVAAEA---EEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ-- 447
L S E+ + E +E A L + A A + LR ++QR QQ
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ---------LREEQQRQQQQM 2527
Query: 448 EELLERLSAEIQEELN-----QRWMRRRQEELAAREEPLEPDGGPDGELLLEQ-ERVRTQ 501
E+ +RL A ++E + +RR+QEEL + LE ELL E+ +R+R Q
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEEL----QQLEQQRRQQEELLAEENQRLREQ 2583
Query: 502 L 502
L
Sbjct: 2584 L 2584
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 401 EPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQE 460
+ +++ E + A+ A Q A E + R+ ++L +L++QR QQEELL + ++E
Sbjct: 2523 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2582
Query: 461 ELNQRWMRRRQEELAAREE 479
+L Q + + LA EE
Sbjct: 2583 QL-QLLEEQHRAALAHSEE 2600
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 21/238 (8%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASV 330
R + A TQ++Q +LAK+ + S + S ++S S R A
Sbjct: 1727 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG- 1780
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
R L ++ + ++ +R +L E D + +R+ + + + +
Sbjct: 1781 -RFRELAEEA-ARLRALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKTE 1837
Query: 391 IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELA--RRCDDLLRLQEQRVQQE 448
E+ E E + AE+ A Q LEE A + D RL + R +
Sbjct: 1838 AEIALKEKEAENERLRRLAEDEAF--------QRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 449 ELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
LER +++ L QR R+ +EE+ A + E EL LE R+R+ +L
Sbjct: 1890 SELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 13/140 (9%)
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWM 467
E EE A A E + A E A + +L E Q + ER + E+Q+ + + +
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAA--LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 468 RR-------RQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVK 520
RR +Q++ + +EE + + E+ Q + R Q + LR+ ++ V+
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKAR-QAEAAERSRLRIEEEIRVVR 1444
Query: 521 SDLDYSQQQWDSKKRELQGL 540
L+ +++Q + ELQ L
Sbjct: 1445 LQLEATERQRGGAEGELQAL 1464
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 13/98 (13%)
Query: 407 AEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERL----SAEIQEEL 462
A A+ A A A E Q EE+ RR + + Q+Q+ +E L++L AEIQ +
Sbjct: 1364 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1423
Query: 463 NQ-----RWMRRRQEELAAREEPLEPD----GGPDGEL 491
Q R R +EE+ LE GG +GEL
Sbjct: 1424 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/319 (21%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 238 RSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKL--AKL 295
R + + R +A V L+ A A + E+ R +A R+L A++
Sbjct: 1525 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1584
Query: 296 NRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRL- 354
R RQ Q + S+ + ++A +ER H+ ++Q +R++ +R
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---LREEAERRA 1641
Query: 355 ----------HELDREIDHYEAKVHLD-RMRRHGVNYVQDTYLVGAGIELDGSRPGEEPE 403
E +RE++ ++ K + R+R Q L A E ++ E
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-------KQKE 1694
Query: 404 EVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN 463
E EA A A + A +EL ++ +QR+ E+ L RL AE ++
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 464 QRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDL 523
QR + +EELA + EL E +VR ++ L R E +S
Sbjct: 1755 QRQL--LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTS 1809
Query: 524 DYSQQQWDSKKRELQGLLQ 542
+ S+Q+ +++ + L +
Sbjct: 1810 EKSKQRLEAEAGRFRELAE 1828
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 34/291 (11%)
Query: 229 QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA 288
+E +R V ++ EA+ G E + + +R A Q++Q + +
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA------------QKRQAQEEAER 1525
Query: 289 FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR 348
R+ + +R++Q +S + A + R +++ +E L + +R
Sbjct: 1526 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR-----ALQALEELRLQAEEAERRLR 1580
Query: 349 Q-QVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAA 407
Q +V+R ++ ++ + + + ++ + T + ++ + + EE
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRA-SFAEKTAQLERSLQEEHVAVAQLREEAER 1639
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRVQQEELLERLSAEIQEELNQR 465
A++ A A EA+ LE + ++ LRL Q + V Q++ L + AE Q+E +R
Sbjct: 1640 RAQQQAEAERAREEAERE-LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 466 WMRRR--QEELAAREEPLE----------PDGGPDGELLLEQERVRTQLST 504
RRR EE A R+ L +G L EQE +R + T
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1749
Score = 40.8 bits (94), Expect = 0.004
Identities = 74/373 (19%), Positives = 137/373 (36%), Gaps = 57/373 (15%)
Query: 228 EQENVRFVLVRSEASLPN-AGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVR 286
+QE +R EA A + EARV RE R L + E+Q +
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156
Query: 287 KAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHT 346
+A KL + +Q+ + + A + + A +E+ + L Q
Sbjct: 2157 QAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2210
Query: 347 IRQQVQRL--------HE---LDREIDHYEAKVHLDRMRRHGVN--------YVQDTYLV 387
+ Q++ L H+ LD E+ +A+ +R V +++ +
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2270
Query: 388 GAGIELDG---------------SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELAR 432
A IE + E+ ++VA EA + A A + A E+LA+
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 433 RCDDLLRLQEQRVQQEELLERLSAEI-----QEELNQRWMRRRQ-----------EELAA 476
+ ++ ++++Q + RL AE Q+EL Q RR Q EE
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390
Query: 477 REEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRE 536
+ LE + E+ E ER++ +++ R D + + + ++ +
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2450
Query: 537 LQGLLQTLHTLEL 549
Q + + TLE+
Sbjct: 2451 TQEKVTLVQTLEI 2463
Score = 37.7 bits (86), Expect = 0.031
Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 29/318 (9%)
Query: 228 EQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRK 287
++ V ++ +AS A AE + L R R + A +L ++ + R+
Sbjct: 1946 QRRQVEEEILALKASFEKAAAGKAELELELGRIR------SNAEDTLRSKEQAELEAARQ 1999
Query: 288 AFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVH----LVLSQ 343
R+LA RR+++ S A ++ R VER++ V L
Sbjct: 2000 --RQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2055
Query: 344 DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSR-PGEEP 402
+ +Q+Q E ++ E K H +++ +Q T + LD R E
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-LQQTLQQEQSV-LDQLRGEAEAA 2113
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
A EAEEA + E +AA + L + E++ Q + + ++++E
Sbjct: 2114 RRAAEEAEEAR----VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2169
Query: 463 NQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSD 522
Q RR Q E AA + D E E+ + +L ++ +L ++
Sbjct: 2170 EQEAARRAQAEQAALRQKQAADA--------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2221
Query: 523 LDYSQQQWDSKKRELQGL 540
L+ + Q + ELQ L
Sbjct: 2222 LEETDHQKNLLDEELQRL 2239
Score = 37.0 bits (84), Expect = 0.054
Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 30/241 (12%)
Query: 279 EKQRRVVRKAFRKLAKLN---RRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
E+QR++ A + KL R Q + A E A+ E++
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2457
Query: 336 LVHLVLSQ---DHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIE 392
+ L + + DH + + + EL+RE + + + L +++ + VQ L+
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 393 LDGSRPGEEPEEVAAEA---EEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ-- 447
L S E+ + E +E A L + A A + LR ++QR QQ
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ---------LREEQQRQQQQM 2568
Query: 448 EELLERLSAEIQEELN-----QRWMRRRQEELAAREEPLEPDGGPDGELLLEQ-ERVRTQ 501
E+ +RL A ++E + +RR+QEEL + LE ELL E+ +R+R Q
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEEL----QQLEQQRRQQEELLAEENQRLREQ 2624
Query: 502 L 502
L
Sbjct: 2625 L 2625
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 401 EPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQE 460
+ +++ E + A+ A Q A E + R+ ++L +L++QR QQEELL + ++E
Sbjct: 2564 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2623
Query: 461 ELNQRWMRRRQEELAAREE 479
+L Q + + LA EE
Sbjct: 2624 QL-QLLEEQHRAALAHSEE 2641
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 21/238 (8%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASV 330
R + A TQ++Q +LAK+ + S + S ++S S R A
Sbjct: 1768 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG- 1821
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
R L ++ + ++ +R +L E D + +R+ + + + +
Sbjct: 1822 -RFRELAEEA-ARLRALAEEAKRQRQLAEE-DAARQRAEAERVLAEKLAAIGEATRLKTE 1878
Query: 391 IELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELA--RRCDDLLRLQEQRVQQE 448
E+ E E + AE+ A Q LEE A + D RL + R +
Sbjct: 1879 AEIALKEKEAENERLRRLAEDEAF--------QRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 449 ELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
LER +++ L QR R+ +EE+ A + E EL LE R+R+ +L
Sbjct: 1931 SELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 13/140 (9%)
Query: 408 EAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWM 467
E EE A A E + A E A + +L E Q + ER + E+Q+ + + +
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAA--LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 468 RR-------RQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVK 520
RR +Q++ + +EE + + E+ Q + R Q + LR+ ++ V+
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI---QAKAR-QAEAAERSRLRIEEEIRVVR 1485
Query: 521 SDLDYSQQQWDSKKRELQGL 540
L+ +++Q + ELQ L
Sbjct: 1486 LQLEATERQRGGAEGELQAL 1505
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 13/98 (13%)
Query: 407 AEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERL----SAEIQEEL 462
A A+ A A A E Q EE+ RR + + Q+Q+ +E L++L AEIQ +
Sbjct: 1405 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1464
Query: 463 NQ-----RWMRRRQEELAAREEPLEPD----GGPDGEL 491
Q R R +EE+ LE GG +GEL
Sbjct: 1465 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502
>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 479
Score = 47.8 bits (112), Expect = 3e-05
Identities = 49/179 (27%), Positives = 73/179 (40%), Gaps = 40/179 (22%)
Query: 328 ASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLV 387
A VE + L L Q+ +R+Q +RLHE + + E
Sbjct: 182 AEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQE---------------------- 219
Query: 388 GAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRL--QEQRV 445
R E+ E + + E E + E+ R C+ RL QE+R+
Sbjct: 220 --------ERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCEQEERL 271
Query: 446 QQEELL---ERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQ 501
++E L ERL E+++ L Q + QE L RE L+ + E LLEQER+R Q
Sbjct: 272 CEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLD-----EVEELLEQERLRQQ 325
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/302 (19%), Positives = 122/302 (40%), Gaps = 56/302 (18%)
Query: 276 MTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMET 335
+ QEK + V + + +L ++QQ P + ++ +
Sbjct: 133 LQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQ----------QQQEQLQTQQA 182
Query: 336 LVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDG 395
VL Q ++QQVQ L ++ + + + L + +L
Sbjct: 183 QEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQE-----------------QLQQ 225
Query: 396 SRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLS 455
+ ++ E++ + ++ G+ Q L++ + L Q+Q Q++LL +
Sbjct: 226 QQFQQQQEQL--QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQ 283
Query: 456 AEIQEELNQRWMRRRQEELAARE---EPLEPDGGPDGEL-----------LLEQERVRTQ 501
++Q++ Q+ ++++QE+L ++ PLEP+ + EL LEQ+R +
Sbjct: 284 EQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELE 343
Query: 502 LSTSL-------YIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQ------GLLQTLHTLE 548
L + L+L +L+ ++ L+ QQQ + ++ +L+ G Q LE
Sbjct: 344 RQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLE 403
Query: 549 LT 550
LT
Sbjct: 404 LT 405
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 42.7 bits (99), Expect = 0.001
Identities = 78/300 (26%), Positives = 116/300 (38%), Gaps = 43/300 (14%)
Query: 279 EKQRRVVRKAFRKL---------AKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESAS 329
E +RR + + ++L A + +R+ Q S + S S+ + S + + +
Sbjct: 560 ESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQA 619
Query: 330 VERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRH-------GVNYVQ 382
E + L +Q+ +R+Q RL E + A+V + R H G V
Sbjct: 620 EELRQEREKLQAAQEE-LRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVL 678
Query: 383 DTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALE-----------ELA 431
LV L SR + + + AE E A A A EA LE L
Sbjct: 679 AKELVEVREAL--SRATLQRDMLQAEKAEVAEALTKA-EAGRVELELSMTKLRAEEASLQ 735
Query: 432 RRCDDLLRLQEQRVQQEELLERLSAEIQEE---LNQRWMRRRQEELAAREEPLEPDGGPD 488
L L E Q + L RL A+++EE L R + QE AREE +
Sbjct: 736 DSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLE---- 791
Query: 489 GELLLEQERVRTQLSTSLYIGLR----LNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTL 544
EL LEQE R L SL + + L L ++ + Q+Q R+L G Q L
Sbjct: 792 -ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQEL 850
Score = 39.3 bits (90), Expect = 0.011
Identities = 74/301 (24%), Positives = 123/301 (40%), Gaps = 62/301 (20%)
Query: 291 KLAKLNRRR--QQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQ--DHT 346
+LA+L+R+ ++Q + + + R E+ + E V LV ++ T
Sbjct: 835 QLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRT 894
Query: 347 IRQQVQRLH-----------ELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDG 395
+ ++ RL E+ R++ EA+ + ++T L G EL G
Sbjct: 895 LSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKET-LTG---ELAG 950
Query: 396 SRPGEEPEEVAAEAEEAAAAPPLAG--------EAQAAALEELARRCDDLLRLQEQRV-- 445
R +++ A E+A+ L EAQA+ E+ A +DL RLQ ++
Sbjct: 951 LR-----QQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA 1005
Query: 446 -----------------QQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPD 488
+QEELL RL AE +EEL++ +QE R+E L
Sbjct: 1006 WRELEAERAQLQSQLQREQEELLARLEAE-KEELSEEIAALQQE----RDEGLLLAESEK 1060
Query: 489 GELLLEQERVRTQLSTSLYIGLR-----LNTDLEAVKSDLDYSQQQWDSKKRELQGLLQT 543
+ L +E +T LS L +G R ++ ++E K D Q+Q S L L+
Sbjct: 1061 QQALSLKESEKTALSEKL-MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRD 1119
Query: 544 L 544
L
Sbjct: 1120 L 1120
Score = 31.6 bits (70), Expect = 2.2
Identities = 46/178 (25%), Positives = 75/178 (42%), Gaps = 29/178 (16%)
Query: 331 ERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
ER+ +L L+Q +++V+R L E D + LD++ R + +DT + A
Sbjct: 1845 ERLGSLQR-ALAQLEAEKREVER-SALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAE 1902
Query: 391 I-ELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEE 449
LD + G E E A+ + EAQ LE+ + Q+Q+++ ++
Sbjct: 1903 KGRLDRTLTGAELELAEAQRQIQQL------EAQVVVLEQSHSPAQLEVDAQQQQLELQQ 1956
Query: 450 LLERL-SAEIQEE----LNQRWMRRR---------------QEELAAREEPLEPDGGP 487
+ERL SA+ Q E +R R+R Q+EL P P GP
Sbjct: 1957 EVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGP 2014
Score = 29.6 bits (65), Expect = 8.5
Identities = 38/146 (26%), Positives = 64/146 (43%), Gaps = 9/146 (6%)
Query: 403 EEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEEL 462
+EVA + E + +A +AQ A ++L + +LQEQ Q L E+++
Sbjct: 797 QEVARQGLEGSLR--VAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
Query: 463 NQRWMRRRQEELAARE-EPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKS 521
+ + E AARE E L + L+ ER LS RL + EA++
Sbjct: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE---ATRLRLEKEALEG 911
Query: 522 DLDYSQQ---QWDSKKRELQGLLQTL 544
L Q+ Q ++++ +L+ Q L
Sbjct: 912 SLFEVQRQLAQLEARREQLEAEGQAL 937
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 41.6 bits (96), Expect = 0.002
Identities = 59/230 (25%), Positives = 91/230 (39%), Gaps = 13/230 (5%)
Query: 328 ASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKV--HLDRMRRHGVNYVQDTY 385
A VE + L L Q+ +R+Q +RL E + + E ++ +R+R +
Sbjct: 182 AEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEE 241
Query: 386 LVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRV 445
+ E R E E + + E E + E+ R C+ RL+EQ
Sbjct: 242 RLCEQEE----RLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEE 297
Query: 446 QQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGG--PDGELLLEQERVRTQLS 503
+ E ERL + + Q R QEE +E L + E LLEQER R +
Sbjct: 298 RLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQER-RQEEQ 356
Query: 504 TSLYIGLRLNTDLEAVKSDLDYSQQQ---WDSKK-RELQGLLQTLHTLEL 549
L RL ++E + QQ W + +EL+ L + LEL
Sbjct: 357 ERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLEL 406
>gi|91208420 bassoon protein [Homo sapiens]
Length = 3926
Score = 40.8 bits (94), Expect = 0.004
Identities = 49/203 (24%), Positives = 81/203 (39%), Gaps = 13/203 (6%)
Query: 389 AGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDD-LLRLQEQRVQQ 447
AG G++P AA + A E + A+ EE R+ + LL+L+ +RV+
Sbjct: 2323 AGAPAPAPLAGQKPPADAAPGGGSGALSRPGFEKEEASQEERQRKQQEQLLQLERERVEL 2382
Query: 448 EELLE-RLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSL 506
E+L + RL E++ E + R +E+L + E E L +QE + Q +
Sbjct: 2383 EKLRQLRLQEELERERVELQRHREEEQLLVQRELQELQTIKHHVLQQQQEERQAQFALQR 2442
Query: 507 YIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREP 566
+ LE ++ QQQ + +K+ + A APG G P
Sbjct: 2443 EQLAQQRLQLEQIQQLQQQLQQQLEEQKQRQKAPFP---------AACEAPGRGPPLAAA 2493
Query: 567 GPQACADMW--VDQARGLAKSGP 587
W + A +A +GP
Sbjct: 2494 ELAQNGQYWPPLTHAAFIAMAGP 2516
Score = 31.2 bits (69), Expect = 2.9
Identities = 48/203 (23%), Positives = 73/203 (35%), Gaps = 16/203 (7%)
Query: 417 PLAGEAQAAALEELARRCDDLLRLQE--QRVQQEEL--LERLSAEIQEELNQRWMRRRQE 472
PL + ++ EE R ++LLR QE + V+Q+ + R + +EEL + R R +
Sbjct: 1032 PLLPTIEDSSEEEELREEEELLREQEKMREVEQQRIRSTARKTRRDKEELRAQRRRERSK 1091
Query: 473 ELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDS 532
+ P+E D P EL E S+ + D EA D S+
Sbjct: 1092 TPPSNLSPIE-DASPTEELRQAAEMEELHRSSCSEYSPSPSLDSEAEALDGGPSRLYKSG 1150
Query: 533 KKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPGPQACADMW-------VDQARGLAKS 585
+ L + E P SG P + +A +M Q +
Sbjct: 1151 SEYNLPTFMSLYSPTETPSGSSTTPSSGRPLKS-AEEAYEEMMRKAELLQRQQGQAAGAR 1209
Query: 586 GPGNDEDSDT---GLSSMHSQDS 605
GP T GL S QD+
Sbjct: 1210 GPHGGPSQPTGPRGLGSFEYQDT 1232
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 40.4 bits (93), Expect = 0.005
Identities = 74/321 (23%), Positives = 123/321 (38%), Gaps = 47/321 (14%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSC------SSSPRT 324
+ +L+ Q++Q ++ + F+ L K+ Q PS S S S +S P
Sbjct: 639 KAALSSQQQQQLALLLQQFQTL-KMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTV 697
Query: 325 HESASVERME---TLVHLVLSQDHTIRQ-QVQRLHELDREIDHYEAKVHLDRMRRHGVNY 380
E SV + T L Q + + + +L + RE + + +R R+ +
Sbjct: 698 WEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRR 757
Query: 381 VQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAA---------AAPPLAGEAQAAALEELA 431
Q+ L + + R E EE+A +E A A E + EE
Sbjct: 758 QQEEILRR---QQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEAL 814
Query: 432 RRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGEL 491
RR ++ R +E+R +QEELL + QEE +W R +E EE L
Sbjct: 815 RRLEERRREEEERRKQEELLRK-----QEEEAAKWAREEEEAQRRLEE---------NRL 860
Query: 492 LLEQERVRTQLSTSLYIGLRLNTDLEAVK-SDLDYSQQQWDSKKRELQGLLQTLHTLELT 550
+E+E R + R +LE + +L +QQ R LQ Q ++
Sbjct: 861 RMEEEAARLRHEEE----ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 916
Query: 551 VAPDGAPGSGSPSREPGPQAC 571
+ P S + ++ AC
Sbjct: 917 L-----PSSSTWGQQSNTTAC 932
Score = 30.8 bits (68), Expect = 3.8
Identities = 49/230 (21%), Positives = 96/230 (41%), Gaps = 35/230 (15%)
Query: 278 QEKQRRVVRKAFRKLAKLNR-----RRQQQTPSSCSSTSSSTASSCSSSPRTHESASVER 332
+E++R+ +A R+L + R R+Q++ ++ A + R E +
Sbjct: 803 EEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRM 862
Query: 333 METLVHLVLSQDHTIRQQ--VQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
E L ++ R++ VQR EL R+ + + +RR Q A
Sbjct: 863 EEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQ-----EALRRLQQQQQQQQL---AQ 914
Query: 391 IELDGSRP-GEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEE 449
++L S G++ A +++ + A +++L + LR +EQR QQ E
Sbjct: 915 MKLPSSSTWGQQSNTTACQSQATLSL---------AEIQKLEEERERQLR-EEQRRQQRE 964
Query: 450 LLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVR 499
L++ L Q+ +++Q++L+ +P G L ++QE R
Sbjct: 965 LMKAL---------QQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEAR 1005
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 40.4 bits (93), Expect = 0.005
Identities = 74/321 (23%), Positives = 123/321 (38%), Gaps = 47/321 (14%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSC------SSSPRT 324
+ +L+ Q++Q ++ + F+ L K+ Q PS S S S +S P
Sbjct: 666 KAALSSQQQQQLALLLQQFQTL-KMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTV 724
Query: 325 HESASVERME---TLVHLVLSQDHTIRQ-QVQRLHELDREIDHYEAKVHLDRMRRHGVNY 380
E SV + T L Q + + + +L + RE + + +R R+ +
Sbjct: 725 WEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRR 784
Query: 381 VQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAA---------AAPPLAGEAQAAALEELA 431
Q+ L + + R E EE+A +E A A E + EE
Sbjct: 785 QQEEILRR---QQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEAL 841
Query: 432 RRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGEL 491
RR ++ R +E+R +QEELL + QEE +W R +E EE L
Sbjct: 842 RRLEERRREEEERRKQEELLRK-----QEEEAAKWAREEEEAQRRLEE---------NRL 887
Query: 492 LLEQERVRTQLSTSLYIGLRLNTDLEAVK-SDLDYSQQQWDSKKRELQGLLQTLHTLELT 550
+E+E R + R +LE + +L +QQ R LQ Q ++
Sbjct: 888 RMEEEAARLRHEEE----ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 943
Query: 551 VAPDGAPGSGSPSREPGPQAC 571
+ P S + ++ AC
Sbjct: 944 L-----PSSSTWGQQSNTTAC 959
Score = 30.8 bits (68), Expect = 3.8
Identities = 49/230 (21%), Positives = 96/230 (41%), Gaps = 35/230 (15%)
Query: 278 QEKQRRVVRKAFRKLAKLNR-----RRQQQTPSSCSSTSSSTASSCSSSPRTHESASVER 332
+E++R+ +A R+L + R R+Q++ ++ A + R E +
Sbjct: 830 EEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRM 889
Query: 333 METLVHLVLSQDHTIRQQ--VQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
E L ++ R++ VQR EL R+ + + +RR Q A
Sbjct: 890 EEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQ-----EALRRLQQQQQQQQL---AQ 941
Query: 391 IELDGSRP-GEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEE 449
++L S G++ A +++ + A +++L + LR +EQR QQ E
Sbjct: 942 MKLPSSSTWGQQSNTTACQSQATLSL---------AEIQKLEEERERQLR-EEQRRQQRE 991
Query: 450 LLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVR 499
L++ L Q+ +++Q++L+ +P G L ++QE R
Sbjct: 992 LMKAL---------QQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEAR 1032
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 40.4 bits (93), Expect = 0.005
Identities = 74/321 (23%), Positives = 123/321 (38%), Gaps = 47/321 (14%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSC------SSSPRT 324
+ +L+ Q++Q ++ + F+ L K+ Q PS S S S +S P
Sbjct: 645 KAALSSQQQQQLALLLQQFQTL-KMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTV 703
Query: 325 HESASVERME---TLVHLVLSQDHTIRQ-QVQRLHELDREIDHYEAKVHLDRMRRHGVNY 380
E SV + T L Q + + + +L + RE + + +R R+ +
Sbjct: 704 WEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRR 763
Query: 381 VQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAA---------AAPPLAGEAQAAALEELA 431
Q+ L + + R E EE+A +E A A E + EE
Sbjct: 764 QQEEILRR---QQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEAL 820
Query: 432 RRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGEL 491
RR ++ R +E+R +QEELL + QEE +W R +E EE L
Sbjct: 821 RRLEERRREEEERRKQEELLRK-----QEEEAAKWAREEEEAQRRLEE---------NRL 866
Query: 492 LLEQERVRTQLSTSLYIGLRLNTDLEAVK-SDLDYSQQQWDSKKRELQGLLQTLHTLELT 550
+E+E R + R +LE + +L +QQ R LQ Q ++
Sbjct: 867 RMEEEAARLRHEEE----ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 922
Query: 551 VAPDGAPGSGSPSREPGPQAC 571
+ P S + ++ AC
Sbjct: 923 L-----PSSSTWGQQSNTTAC 938
Score = 30.8 bits (68), Expect = 3.8
Identities = 49/230 (21%), Positives = 96/230 (41%), Gaps = 35/230 (15%)
Query: 278 QEKQRRVVRKAFRKLAKLNR-----RRQQQTPSSCSSTSSSTASSCSSSPRTHESASVER 332
+E++R+ +A R+L + R R+Q++ ++ A + R E +
Sbjct: 809 EEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRM 868
Query: 333 METLVHLVLSQDHTIRQQ--VQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
E L ++ R++ VQR EL R+ + + +RR Q A
Sbjct: 869 EEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQ-----EALRRLQQQQQQQQL---AQ 920
Query: 391 IELDGSRP-GEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEE 449
++L S G++ A +++ + A +++L + LR +EQR QQ E
Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSL---------AEIQKLEEERERQLR-EEQRRQQRE 970
Query: 450 LLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVR 499
L++ L Q+ +++Q++L+ +P G L ++QE R
Sbjct: 971 LMKAL---------QQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEAR 1011
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 40.4 bits (93), Expect = 0.005
Identities = 74/321 (23%), Positives = 123/321 (38%), Gaps = 47/321 (14%)
Query: 271 RPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSC------SSSPRT 324
+ +L+ Q++Q ++ + F+ L K+ Q PS S S S +S P
Sbjct: 645 KAALSSQQQQQLALLLQQFQTL-KMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTV 703
Query: 325 HESASVERME---TLVHLVLSQDHTIRQ-QVQRLHELDREIDHYEAKVHLDRMRRHGVNY 380
E SV + T L Q + + + +L + RE + + +R R+ +
Sbjct: 704 WEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRR 763
Query: 381 VQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAA---------AAPPLAGEAQAAALEELA 431
Q+ L + + R E EE+A +E A A E + EE
Sbjct: 764 QQEEILRR---QQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEAL 820
Query: 432 RRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGEL 491
RR ++ R +E+R +QEELL + QEE +W R +E EE L
Sbjct: 821 RRLEERRREEEERRKQEELLRK-----QEEEAAKWAREEEEAQRRLEE---------NRL 866
Query: 492 LLEQERVRTQLSTSLYIGLRLNTDLEAVK-SDLDYSQQQWDSKKRELQGLLQTLHTLELT 550
+E+E R + R +LE + +L +QQ R LQ Q ++
Sbjct: 867 RMEEEAARLRHEEE----ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 922
Query: 551 VAPDGAPGSGSPSREPGPQAC 571
+ P S + ++ AC
Sbjct: 923 L-----PSSSTWGQQSNTTAC 938
Score = 30.8 bits (68), Expect = 3.8
Identities = 49/230 (21%), Positives = 96/230 (41%), Gaps = 35/230 (15%)
Query: 278 QEKQRRVVRKAFRKLAKLNR-----RRQQQTPSSCSSTSSSTASSCSSSPRTHESASVER 332
+E++R+ +A R+L + R R+Q++ ++ A + R E +
Sbjct: 809 EEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRM 868
Query: 333 METLVHLVLSQDHTIRQQ--VQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAG 390
E L ++ R++ VQR EL R+ + + +RR Q A
Sbjct: 869 EEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQ-----EALRRLQQQQQQQQL---AQ 920
Query: 391 IELDGSRP-GEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEE 449
++L S G++ A +++ + A +++L + LR +EQR QQ E
Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSL---------AEIQKLEEERERQLR-EEQRRQQRE 970
Query: 450 LLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVR 499
L++ L Q+ +++Q++L+ +P G L ++QE R
Sbjct: 971 LMKAL---------QQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEAR 1011
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 40.4 bits (93), Expect = 0.005
Identities = 61/250 (24%), Positives = 100/250 (40%), Gaps = 41/250 (16%)
Query: 328 ASVERMETLVHLVLSQDHTIRQQVQRLHELDREI--DHYEAKVHLDRMRRHGVNYVQD-- 383
A ++E + + QDH+ + ++ L RE+ +H E K+ L R +Q+
Sbjct: 828 AQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERE 887
Query: 384 ---TYLVGAGIELDGS--RPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLL 438
T L A L+ + E EE AEAEE +A A +E+ R+ D L
Sbjct: 888 SQLTALQAARAALESQLRQAKTELEETTAEAEEEI-------QALTAHRDEIQRKFDALR 940
Query: 439 RLQEQRVQQEELLERLSAEIQEELNQRWMRRRQ--EELAAREEPLEPDGGPD-------- 488
EE L +L+ + E NQ + +Q E A +E ++ D
Sbjct: 941 NSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITE 1000
Query: 489 -GELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDS--------------K 533
L Q++ L T+ + DLEA+ +L ++QW++ +
Sbjct: 1001 REMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECR 1060
Query: 534 KRELQGLLQT 543
RELQ +L T
Sbjct: 1061 VRELQRMLDT 1070
>gi|46249351 homer 2 isoform 2 [Homo sapiens]
Length = 354
Score = 40.4 bits (93), Expect = 0.005
Identities = 28/118 (23%), Positives = 57/118 (48%), Gaps = 13/118 (11%)
Query: 427 LEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGG 486
++EL +C ++ R +E+ Q + +E L AE++E+ + R+Q E+
Sbjct: 229 IDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIP---------- 278
Query: 487 PDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTL 544
+L+ E E V +L + L + ++K+D++ S+ + K EL+ L+ L
Sbjct: 279 ---QLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 333
>gi|46249349 homer 2 isoform 1 [Homo sapiens]
Length = 343
Score = 40.4 bits (93), Expect = 0.005
Identities = 28/118 (23%), Positives = 57/118 (48%), Gaps = 13/118 (11%)
Query: 427 LEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGG 486
++EL +C ++ R +E+ Q + +E L AE++E+ + R+Q E+
Sbjct: 218 IDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIP---------- 267
Query: 487 PDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTL 544
+L+ E E V +L + L + ++K+D++ S+ + K EL+ L+ L
Sbjct: 268 ---QLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 322
>gi|38348729 hypothetical protein LOC203238 [Homo sapiens]
Length = 1326
Score = 40.4 bits (93), Expect = 0.005
Identities = 48/213 (22%), Positives = 92/213 (43%), Gaps = 18/213 (8%)
Query: 347 IRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVA 406
++Q ++ ELD D+ K+H + + + + L ++ R E E
Sbjct: 22 VKQILKNETELDIT-DNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEAL 80
Query: 407 AEAEE--AAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELN- 463
++ E A A AG + AA E LA + R+QE+ Q L+ + E ++
Sbjct: 81 RQSLEYDLAVARKEAGLGRRAAEERLA----EAHRIQEKLCAQNSELQAKTNETEKAFQT 136
Query: 464 --QRWM---RRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEA 518
Q+W RR + +L R+ ++ L+ E+ R+ L +L R ++E+
Sbjct: 137 SQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMES 196
Query: 519 -----VKSDLDYSQQQWDSKKRELQGLLQTLHT 546
+ ++QW++++RELQ ++Q T
Sbjct: 197 HIRETALEEFRLQEEQWEAERRELQFIVQEQDT 229
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 40.0 bits (92), Expect = 0.006
Identities = 54/239 (22%), Positives = 104/239 (43%), Gaps = 38/239 (15%)
Query: 321 SPRTHESASVERMETLVHLVLSQDHTIRQQVQRL--HELDREIDH-----YEAKVHLDRM 373
+PR ++ ++ + L ++H+ R ++L H R+ + + K H+DR
Sbjct: 250 APRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRT 309
Query: 374 RRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAA----LEE 429
++ G E + G E EE ++ E ++ L GE+ L+
Sbjct: 310 KKKR----------GEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 430 LARRCDDLLR---LQEQRVQQEELLERLSAEIQEELN-QRWMRRRQEELAAREEPLEPDG 485
+ + LR L++Q+ + EE +L AE Q+ + Q+ RRR EE RE+
Sbjct: 360 ANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK------ 413
Query: 486 GPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTL 544
EL +QER + + +R + + + +Y ++Q + ++R+L+ L Q L
Sbjct: 414 ----ELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 2/77 (2%)
Query: 423 QAAALEELARRCDDLLRLQE--QRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEP 480
Q LEE RR +L + QE QR EE + R + E Q ++RR+ EE + E
Sbjct: 401 QRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI 460
Query: 481 LEPDGGPDGELLLEQER 497
L+ + LLLE +R
Sbjct: 461 LQQQLLHEQALLLEYKR 477
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 40.0 bits (92), Expect = 0.006
Identities = 54/239 (22%), Positives = 104/239 (43%), Gaps = 38/239 (15%)
Query: 321 SPRTHESASVERMETLVHLVLSQDHTIRQQVQRL--HELDREIDH-----YEAKVHLDRM 373
+PR ++ ++ + L ++H+ R ++L H R+ + + K H+DR
Sbjct: 250 APRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRT 309
Query: 374 RRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAA----LEE 429
++ G E + G E EE ++ E ++ L GE+ L+
Sbjct: 310 KKKR----------GEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 430 LARRCDDLLR---LQEQRVQQEELLERLSAEIQEELN-QRWMRRRQEELAAREEPLEPDG 485
+ + LR L++Q+ + EE +L AE Q+ + Q+ RRR EE RE+
Sbjct: 360 ANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK------ 413
Query: 486 GPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTL 544
EL +QER + + +R + + + +Y ++Q + ++R+L+ L Q L
Sbjct: 414 ----ELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 2/77 (2%)
Query: 423 QAAALEELARRCDDLLRLQE--QRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEP 480
Q LEE RR +L + QE QR EE + R + E Q ++RR+ EE + E
Sbjct: 401 QRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI 460
Query: 481 LEPDGGPDGELLLEQER 497
L+ + LLLE +R
Sbjct: 461 LQQQLLHEQALLLEYKR 477
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 40.0 bits (92), Expect = 0.006
Identities = 54/239 (22%), Positives = 104/239 (43%), Gaps = 38/239 (15%)
Query: 321 SPRTHESASVERMETLVHLVLSQDHTIRQQVQRL--HELDREIDH-----YEAKVHLDRM 373
+PR ++ ++ + L ++H+ R ++L H R+ + + K H+DR
Sbjct: 250 APRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRT 309
Query: 374 RRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAA----LEE 429
++ G E + G E EE ++ E ++ L GE+ L+
Sbjct: 310 KKKR----------GEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 430 LARRCDDLLR---LQEQRVQQEELLERLSAEIQEELN-QRWMRRRQEELAAREEPLEPDG 485
+ + LR L++Q+ + EE +L AE Q+ + Q+ RRR EE RE+
Sbjct: 360 ANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK------ 413
Query: 486 GPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTL 544
EL +QER + + +R + + + +Y ++Q + ++R+L+ L Q L
Sbjct: 414 ----ELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 2/77 (2%)
Query: 423 QAAALEELARRCDDLLRLQE--QRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEP 480
Q LEE RR +L + QE QR EE + R + E Q ++RR+ EE + E
Sbjct: 401 QRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI 460
Query: 481 LEPDGGPDGELLLEQER 497
L+ + LLLE +R
Sbjct: 461 LQQQLLHEQALLLEYKR 477
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 40.0 bits (92), Expect = 0.006
Identities = 54/239 (22%), Positives = 104/239 (43%), Gaps = 38/239 (15%)
Query: 321 SPRTHESASVERMETLVHLVLSQDHTIRQQVQRL--HELDREIDH-----YEAKVHLDRM 373
+PR ++ ++ + L ++H+ R ++L H R+ + + K H+DR
Sbjct: 250 APRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRT 309
Query: 374 RRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAA----LEE 429
++ G E + G E EE ++ E ++ L GE+ L+
Sbjct: 310 KKKR----------GEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 430 LARRCDDLLR---LQEQRVQQEELLERLSAEIQEELN-QRWMRRRQEELAAREEPLEPDG 485
+ + LR L++Q+ + EE +L AE Q+ + Q+ RRR EE RE+
Sbjct: 360 ANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK------ 413
Query: 486 GPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTL 544
EL +QER + + +R + + + +Y ++Q + ++R+L+ L Q L
Sbjct: 414 ----ELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 2/77 (2%)
Query: 423 QAAALEELARRCDDLLRLQE--QRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEP 480
Q LEE RR +L + QE QR EE + R + E Q ++RR+ EE + E
Sbjct: 401 QRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI 460
Query: 481 LEPDGGPDGELLLEQER 497
L+ + LLLE +R
Sbjct: 461 LQQQLLHEQALLLEYKR 477
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 40.0 bits (92), Expect = 0.006
Identities = 55/218 (25%), Positives = 92/218 (42%), Gaps = 22/218 (10%)
Query: 365 EAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQA 424
+ K H+DR R+ + Y E GS EE EEV + E ++ + GE+
Sbjct: 301 QLKDHIDRTRKKRGEKDETEY------EYSGSE--EEEEEVPEQEGEPSSIVNVPGESTL 352
Query: 425 AA-----LEELARRCDDLLR---LQEQRV-QQEELLERLSAEIQEEL-NQRWMRRRQEEL 474
+E R + L R LQEQ++ +QEE +L AE Q+ + Q+ RRR EE
Sbjct: 353 RRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQ 412
Query: 475 AAREEPLEPDGGPDGELLLEQERVRTQ----LSTSLYIGLRLNTDLEAVKSDLDYSQQQW 530
RE + ++E+ R + R + V+ + +Y ++Q
Sbjct: 413 QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQL 472
Query: 531 DSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPGP 568
+ ++R L+ L Q L + + D S++P P
Sbjct: 473 EEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPP 510
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 40.0 bits (92), Expect = 0.006
Identities = 55/218 (25%), Positives = 92/218 (42%), Gaps = 22/218 (10%)
Query: 365 EAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQA 424
+ K H+DR R+ + Y E GS EE EEV + E ++ + GE+
Sbjct: 301 QLKDHIDRTRKKRGEKDETEY------EYSGSE--EEEEEVPEQEGEPSSIVNVPGESTL 352
Query: 425 AA-----LEELARRCDDLLR---LQEQRV-QQEELLERLSAEIQEEL-NQRWMRRRQEEL 474
+E R + L R LQEQ++ +QEE +L AE Q+ + Q+ RRR EE
Sbjct: 353 RRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQ 412
Query: 475 AAREEPLEPDGGPDGELLLEQERVRTQ----LSTSLYIGLRLNTDLEAVKSDLDYSQQQW 530
RE + ++E+ R + R + V+ + +Y ++Q
Sbjct: 413 QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQL 472
Query: 531 DSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPGP 568
+ ++R L+ L Q L + + D S++P P
Sbjct: 473 EEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPP 510
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,631,349
Number of Sequences: 37866
Number of extensions: 1584654
Number of successful extensions: 11556
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 412
Number of HSP's that attempted gapping in prelim test: 9808
Number of HSP's gapped (non-prelim): 1536
length of query: 615
length of database: 18,247,518
effective HSP length: 108
effective length of query: 507
effective length of database: 14,157,990
effective search space: 7178100930
effective search space used: 7178100930
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.