Search of human proteins with 122937400

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]
         (2699 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]              5543   0.0  
gi|170016091 odz, odd Oz/ten-m homolog 2 [Homo sapiens]              3892   0.0  
gi|169790825 odz, odd Oz/ten-m homolog 4 [Homo sapiens]              3889   0.0  
gi|110347400 odz, odd Oz/ten-m homolog 1 isoform 3 [Homo sapiens]    3433   0.0  
gi|253970444 odz, odd Oz/ten-m homolog 1 isoform 1 [Homo sapiens]    3426   0.0  
gi|253970446 odz, odd Oz/ten-m homolog 1 isoform 2 [Homo sapiens]    3420   0.0  
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]           234   1e-60
gi|153946395 tenascin C precursor [Homo sapiens]                      233   1e-60
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...   157   2e-37
gi|24041035 notch 2 preproprotein [Homo sapiens]                      154   9e-37
gi|4557679 jagged 1 precursor [Homo sapiens]                          152   4e-36
gi|148833508 notch1 preproprotein [Homo sapiens]                      144   1e-33
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]   142   3e-33
gi|134244285 Notch homolog 3 [Homo sapiens]                           142   6e-33
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]               140   2e-32
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               139   3e-32
gi|157384973 tenascin R [Homo sapiens]                                139   3e-32
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]              139   3e-32
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               139   5e-32
gi|4758614 integrin, beta-like 1 (with EGF-like repeat domains) ...   139   5e-32
gi|55770876 notch4 preproprotein [Homo sapiens]                       135   7e-31
gi|116235485 delta-notch-like EGF repeat-containing transmembran...   131   1e-29
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               125   6e-28
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               122   4e-27
gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]         122   6e-27
gi|33598931 scavenger receptor class F, member 1 isoform 3 precu...   119   4e-26
gi|33598929 scavenger receptor class F, member 1 isoform 1 precu...   119   4e-26
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                 119   5e-26
gi|145309306 scavenger receptor class F, member 1 isoform 5 prec...   118   7e-26
gi|110735443 delta-like 1 [Homo sapiens]                              113   2e-24

>gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]
          Length = 2699

 Score = 5543 bits (14379), Expect = 0.0
 Identities = 2699/2699 (100%), Positives = 2699/2699 (100%)

Query: 1    MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG 60
            MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG
Sbjct: 1    MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG 60

Query: 61   NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEMGLPHRGYSISAGSDADT 120
            NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEMGLPHRGYSISAGSDADT
Sbjct: 61   NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEMGLPHRGYSISAGSDADT 120

Query: 121  ENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSENEQPASNQGQS 180
            ENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSENEQPASNQGQS
Sbjct: 121  ENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSENEQPASNQGQS 180

Query: 181  TLQPLPPSHKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWV 240
            TLQPLPPSHKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWV
Sbjct: 181  TLQPLPPSHKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWV 240

Query: 241  LGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKK 300
            LGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKK
Sbjct: 241  LGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKK 300

Query: 301  SSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFGLNWQLQQTENDTFENGKVNSDTMPT 360
            SSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFGLNWQLQQTENDTFENGKVNSDTMPT
Sbjct: 301  SSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFGLNWQLQQTENDTFENGKVNSDTMPT 360

Query: 361  NTVSLPSGDNGKLGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNI 420
            NTVSLPSGDNGKLGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNI
Sbjct: 361  NTVSLPSGDNGKLGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNI 420

Query: 421  SLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSLLETERAGRQARSVSLHEA 480
            SLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSLLETERAGRQARSVSLHEA
Sbjct: 421  SLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSLLETERAGRQARSVSLHEA 480

Query: 481  GFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFL 540
            GFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFL
Sbjct: 481  GFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFL 540

Query: 541  GPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCAC 600
            GPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCAC
Sbjct: 541  GPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCAC 600

Query: 601  NSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQ 660
            NSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQ
Sbjct: 601  NSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQ 660

Query: 661  ESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHG 720
            ESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHG
Sbjct: 661  ESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHG 720

Query: 721  TCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETL 780
            TCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETL
Sbjct: 721  TCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETL 780

Query: 781  CTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDR 840
            CTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDR
Sbjct: 781  CTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDR 840

Query: 841  ISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQD 900
            ISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQD
Sbjct: 841  ISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQD 900

Query: 901  GMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFV 960
            GMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFV
Sbjct: 901  GMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFV 960

Query: 961  RPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKI 1020
            RPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKI
Sbjct: 961  RPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKI 1020

Query: 1021 TMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVS 1080
            TMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVS
Sbjct: 1021 TMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVS 1080

Query: 1081 VGYEYESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFIS 1140
            VGYEYESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFIS
Sbjct: 1081 VGYEYESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFIS 1140

Query: 1141 QQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPS 1200
            QQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPS
Sbjct: 1141 QQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPS 1200

Query: 1201 GNVTSVLELSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGT 1260
            GNVTSVLELSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGT
Sbjct: 1201 GNVTSVLELSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGT 1260

Query: 1261 GEQCLPFDEARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGS 1320
            GEQCLPFDEARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGS
Sbjct: 1261 GEQCLPFDEARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGS 1320

Query: 1321 NDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGR 1380
            NDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGR
Sbjct: 1321 NDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGR 1380

Query: 1381 PMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISL 1440
            PMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISL
Sbjct: 1381 PMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISL 1440

Query: 1441 VAGIPSECDCKNDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSK 1500
            VAGIPSECDCKNDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSK
Sbjct: 1441 VAGIPSECDCKNDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSK 1500

Query: 1501 NKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSN 1560
            NKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSN
Sbjct: 1501 NKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSN 1560

Query: 1561 GNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATK 1620
            GNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATK
Sbjct: 1561 GNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATK 1620

Query: 1621 SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSS 1680
            SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSS
Sbjct: 1621 SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSS 1680

Query: 1681 IDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPG 1740
            IDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPG
Sbjct: 1681 IDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPG 1740

Query: 1741 ENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIA 1800
            ENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIA
Sbjct: 1741 ENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIA 1800

Query: 1801 YDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTW 1860
            YDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTW
Sbjct: 1801 YDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTW 1860

Query: 1861 SYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPES 1920
            SYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPES
Sbjct: 1861 SYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPES 1920

Query: 1921 NASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTV 1980
            NASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTV
Sbjct: 1921 NASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTV 1980

Query: 1981 NLQSDGFICTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLP 2040
            NLQSDGFICTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLP
Sbjct: 1981 NLQSDGFICTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLP 2040

Query: 2041 IDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMY 2100
            IDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMY
Sbjct: 2041 IDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMY 2100

Query: 2101 WITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLH 2160
            WITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLH
Sbjct: 2101 WITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLH 2160

Query: 2161 LLNPSNSARLTPLRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKG 2220
            LLNPSNSARLTPLRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKG
Sbjct: 2161 LLNPSNSARLTPLRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKG 2220

Query: 2221 SGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGH 2280
            SGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGH
Sbjct: 2221 SGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGH 2280

Query: 2281 LFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHG 2340
            LFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHG
Sbjct: 2281 LFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHG 2340

Query: 2341 GLYDPLTKLIHFGERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVK 2400
            GLYDPLTKLIHFGERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVK
Sbjct: 2341 GLYDPLTKLIHFGERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVK 2400

Query: 2401 DYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQQWDDIPPIFGVQQQVARQ 2460
            DYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQQWDDIPPIFGVQQQVARQ
Sbjct: 2401 DYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQQWDDIPPIFGVQQQVARQ 2460

Query: 2461 AKAFLSLGKMAEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANED 2520
            AKAFLSLGKMAEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANED
Sbjct: 2461 AKAFLSLGKMAEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANED 2520

Query: 2521 CIKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVS 2580
            CIKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVS
Sbjct: 2521 CIKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVS 2580

Query: 2581 QSTTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRV 2640
            QSTTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRV
Sbjct: 2581 QSTTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRV 2640

Query: 2641 RDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR 2699
            RDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR
Sbjct: 2641 RDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR 2699


>gi|170016091 odz, odd Oz/ten-m homolog 2 [Homo sapiens]
          Length = 2765

 Score = 3892 bits (10092), Expect = 0.0
 Identities = 1863/2782 (66%), Positives = 2247/2782 (80%), Gaps = 100/2782 (3%)

Query: 1    MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG 60
            MDVK+RR + SLT+ R  KE RYT+SS D+E+CRVPTQKSYSSSETLKA+DHDS R+ YG
Sbjct: 1    MDVKDRR-HRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDS-RMHYG 58

Query: 61   NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRR------------------------- 95
            NRV DL+HRE+DEF RQG NFTL +LG+CEP+  R                         
Sbjct: 59   NRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSD 118

Query: 96   ----------------GLAFCAEMGLPHRGYSISAGSDADTENEA-------VMSPEHAM 132
                            G+      GL  R  S    +D+D EN++       +       
Sbjct: 119  TEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPS 178

Query: 133  RLWGRGVKSGRS----SC----LSSRSNSALTLTDTEHENKSDS------------ENEQ 172
             L    + S  +    SC    L S ++  +  T+ + E   +S             +  
Sbjct: 179  LLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSG 238

Query: 173  PASNQGQSTLQP-LPPSHKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPE 231
            P ++  QSTL+P LPP H    + HH S  SLNRNSLTNRR+Q  AP  A P +L TTPE
Sbjct: 239  PPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPA-PNDLATTPE 297

Query: 232  SVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTL 291
            SVQLQDSWVL SNVPLE+RHFLFKT +G+TPLFS+++PGY + SG+VY+PP R LPRNT 
Sbjct: 298  SVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTF 357

Query: 292  SRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFGLNWQLQQTENDTFENG 351
            SR AFK KK SKYCSWKC AL A+  ++LLAILL+YFIAMHL GLNWQLQ  +  TF NG
Sbjct: 358  SRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIAMHLLGLNWQLQPADGHTFNNG 417

Query: 352  KVNSDTMPTNTVSLPSGDNGKLGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFID 411
                     +  ++PSG  GK+  ++ +N++IDSGE ++GRR  QE+PPG+FWRSQ+ I 
Sbjct: 418  IRTGLPGNDDVATMPSG--GKVP-WSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHIS 474

Query: 412  QPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSLLETERAGRQ 471
            QPQFLKFNISL KDAL GVY R+GLPPSH QYDF+E LDG     +E+ S++E+ R  R 
Sbjct: 475  QPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG-----KEKWSVVESPRERRS 529

Query: 472  ARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSG 531
             +++  +EA F+QYLD G+WHLAFYNDGK+ E VSFNT+V++SV +CPRNCHGNGECVSG
Sbjct: 530  IQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSG 589

Query: 532  TCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRG 591
             CHCFPGFLG DC++AACPVLCSGNGQYSKG C C+SGWKG ECDVP  QCIDP CGG G
Sbjct: 590  VCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHG 649

Query: 592  ICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCEILKTMCPDQ 651
             CI G+C C++GYKGE CEE DC+DP CS+HGVC++GEC CSPGWGG NCE+ +  CPDQ
Sbjct: 650  SCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQ 709

Query: 652  CSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRA 711
            CSGHGTYL ++G C+CDPNW GPDCS E+CSVDCG+HGVC+GG CRCEEGWTG AC+QR 
Sbjct: 710  CSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRV 769

Query: 712  CHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGA 771
            CHPRC EHGTCKDGKCEC +GWNGEHCTI+GCP LCN NGRCTL QN W CVCQ GWRG 
Sbjct: 770  CHPRCIEHGTCKDGKCECREGWNGEHCTIDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGP 829

Query: 772  GCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQSPSQ 831
            GC+VAMET C D+KDNEGDGL+DC+DPDCCLQS+CQN   CRG  DP DII Q       
Sbjct: 830  GCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQG--QTDW 887

Query: 832  QAAKSFYDRISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPE 891
             A KSFYDRI  L G DSTH+IPGE+PFN SL S+IRGQV+T DGTPL+GVNVSF  YP+
Sbjct: 888  PAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPK 947

Query: 892  YGYTITRQDGMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDI 951
            YGYTITRQDG FDL+ANGGASLTL FER+PF++Q  TVW+PWN FY MDTLVMK EEN I
Sbjct: 948  YGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSI 1007

Query: 952  PSCDLSGFVRPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRA 1011
            PSCDLSGFVRP+PII+SSPLSTFF ++P  +PI+PETQVLHEE  +PG+++KL YLSSR 
Sbjct: 1008 PSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLRYLSSRT 1067

Query: 1012 AGYKSVLKITMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKV 1071
            AGYKS+LKITMTQS +P NL++VHLMVAV G LFQK F ASPNLAYTFIWDKTDAY Q+V
Sbjct: 1068 AGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRV 1127

Query: 1072 YGLSEAVVSVGYEYESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYK 1131
            YGLS+AVVSVG+EYE+C  L LWEKRTA+LQG+ELD SN+GGW+LDKHH+L+V++GIL+K
Sbjct: 1128 YGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHK 1187

Query: 1132 GNGENQFISQQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDF 1191
            G GENQF++QQP +++SIMGNGRRRSISCPSCNG A+GNKLLAPVALA GIDGSLYVGDF
Sbjct: 1188 GTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDF 1247

Query: 1192 NYVRRIFPSGNVTSVLEL-------SSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSL 1244
            NY+RRIFPS NVTS+LEL       S+NPAH+YYLA DPV+G LYVSDTN+RRIYR KSL
Sbjct: 1248 NYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSL 1307

Query: 1245 TGAKDLTKNAEVVAGTGEQCLPFDEARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGTM 1304
            +G KDL  N+EVVAGTGEQCLPFDEARCGDGGKA++ATLMSP+G+AVDKNGL+YFVD TM
Sbjct: 1308 SGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATM 1367

Query: 1305 IRKVDQNGIISTLLGSNDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNNV 1364
            IRKVDQNGIISTLLGSNDLT+ RPL+CD+SM ++QVRLEWPTDLA+NPMDNS+YVL+NNV
Sbjct: 1368 IRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNV 1427

Query: 1365 VLQITENRQVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEK 1424
            +L+ITEN QV I AGRPMHCQVPG++Y + K A+ + LESA+AIA+S++GVLYITETDEK
Sbjct: 1428 ILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEK 1487

Query: 1425 KINRIRQVTTDGEISLVAGIPSECDCKNDANCDCYQSGDGYAKDAKLSAPSSLAASPDGT 1484
            KINR+RQVTT+GEI L+AG  S+CDCKND NC+CY   D YA DA L++PSSLA +PDGT
Sbjct: 1488 KINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGT 1547

Query: 1485 LYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYN 1544
            +YIADLGNIRIRAVSKNKP+LN+ N YE ASP +QELY+F+ +G HQYTVSLVTG+YLYN
Sbjct: 1548 IYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYN 1607

Query: 1545 FSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLE 1604
            F+YS DND+T + D+NGN+L+IRRD + MP  ++ PDNQ+I LT+GTNG LK ++ Q LE
Sbjct: 1608 FTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLE 1667

Query: 1605 LVLFTYHGNSGLLATKSDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIE 1664
            L L TY GN+GLLATKSDETGWTTF+DYD EGRLTNVT PTGVVT+LH +M+K+IT+DIE
Sbjct: 1668 LGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIE 1727

Query: 1665 SSSREEDVSITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLA 1724
            +S+R++DV++ +NLSS+++ YT+VQDQ+RNSYQ+  +G+LR++YA+G+   + +EPHVLA
Sbjct: 1728 NSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLA 1787

Query: 1725 GTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTK 1784
            GT  PT+ + N++LP ENG N +EWR RKEQ +GKV +FGRKLRV+GRNLLS+D+DR  +
Sbjct: 1788 GTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIR 1847

Query: 1785 TEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYD 1844
            TEKIYDDHRKF LRI YD  G P LWLPSS L AVNV+Y   G++A +QRG  SE+ D D
Sbjct: 1848 TEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDID 1907

Query: 1845 GQGRIVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQT 1904
             QGRIVSR+FADGK WSY+YL+KSMVLLL SQRQYIFEYD  DRL A+TMPSVARH+M T
Sbjct: 1908 KQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLLAVTMPSVARHSMST 1967

Query: 1905 IRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDST 1964
              SIGY RNIYNPPESNAS+I DY+++G +L+T+FLGT R+V +KY + ++LSEI+YDST
Sbjct: 1968 HTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDST 2027

Query: 1965 RVSFTYDETAGVLKTVNLQSDGFICTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSY-DN 2023
             V+F YDET GVLK VNLQS GF CTIRYR+IGPL+D+QI+RFSE+GMVNARFDY+Y DN
Sbjct: 2028 AVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDN 2087

Query: 2024 SFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDA 2083
            SFR+ S++ VI+ETPLP+DLY++D+ISGKVE FGKFGVIYYDINQII+TAVMT +KHFD 
Sbjct: 2088 SFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDT 2147

Query: 2084 HGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYL 2143
            HGRIKE+QYE+FRSLMYW+T+QYD+MGRV KRE+K+GP+ANTTKY Y+YD DGQLQ+V +
Sbjct: 2148 HGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAV 2207

Query: 2144 NEKIMWRYNYDLNGNLHLLNPSNSARLTPLRYDLRDRITRLGDVQYRLDEDGFLRQRGTE 2203
            N++  WRY+YDLNGNLHLLNP NS RL PLRYDLRDRITRLGDVQY++D+DG+L QRG++
Sbjct: 2208 NDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSD 2267

Query: 2204 IFEYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHVY 2263
            IFEY+SKGLLTR Y+K SGW+V YRYDG+GRR S KT+LG HLQ+FY+DL  PTRITHVY
Sbjct: 2268 IFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVY 2327

Query: 2264 NHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGE 2323
            NHS+SEITSLYYDLQGHLFAME SSG+E+Y+ASDNTGTPLAVFS NGLM+KQ+QYTAYGE
Sbjct: 2328 NHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGE 2387

Query: 2324 IYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDIEIWKRIGKDPAPFN 2383
            IY+DSN DFQ+VIGFHGGLYDPLTKL+HF +RDYD+LAGRWT+PD  +WK +GK+PAPFN
Sbjct: 2388 IYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFN 2447

Query: 2384 LYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQQ 2443
            LYMF++NNP S   D+K+Y+TDV SWLV FGF L N IPGFP  K     P YEL +SQ 
Sbjct: 2448 LYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQA 2507

Query: 2444 WDDIPPIFGVQQQVARQAKAFLSLGKMAEVQVSRRRAGGA---QSWLWFATVKSLIGKGV 2500
             ++   I GVQQ   R  +AF++L    E QV  ++   +   ++  WFAT   +IGKG+
Sbjct: 2508 SENGQLITGVQQTTERHNQAFMAL----EGQVITKKLHASIREKAGHWFATTTPIIGKGI 2563

Query: 2501 MLAVSQGRVQTNVLNIANEDCIKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLG 2560
            M A+ +GRV T V +IA+ED  KVA+VLNNA+YL+ +H++IEGKDTHYF+K  + + DL 
Sbjct: 2564 MFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGSADGDLV 2623

Query: 2561 TLRLTSGRKALENGINVTVSQSTTVVNGRTRRFADVEMQFGALALHVRYGM---TLDEEK 2617
            TL  T GRK LE+G+NVTVSQ T +VNGRTRRF ++E Q+  L L +RYG+   TLDEEK
Sbjct: 2624 TLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEK 2683

Query: 2618 ARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQ 2677
            AR+L+QARQRAL  AWA+EQQ+ RDG EG+RLWTEGEK+QLLS G+VQGY+GYYVL VEQ
Sbjct: 2684 ARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQ 2743

Query: 2678 YPELADSANNIQFLRQSEIGRR 2699
            YPELADS++NIQFLRQ+E+G+R
Sbjct: 2744 YPELADSSSNIQFLRQNEMGKR 2765


>gi|169790825 odz, odd Oz/ten-m homolog 4 [Homo sapiens]
          Length = 2769

 Score = 3889 bits (10085), Expect = 0.0
 Identities = 1861/2777 (67%), Positives = 2218/2777 (79%), Gaps = 86/2777 (3%)

Query: 1    MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG 60
            MDVKER+PY SLT+ RR+ ERRYT+SSAD+EE + P QKSYSSSETLKA+D D+ RL YG
Sbjct: 1    MDVKERKPYRSLTR-RRDAERRYTSSSADSEEGKAP-QKSYSSSETLKAYDQDA-RLAYG 57

Query: 61   NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEMGLPHRGYSISAGSDADT 120
            +RVKD+V +EA+EF R G NFTLR+LG+ E     G  +  ++GLPH GYS+ AGSDAD 
Sbjct: 58   SRVKDIVPQEAEEFCRTGANFTLRELGLEEVTPPHGTLYRTDIGLPHCGYSMGAGSDADM 117

Query: 121  ENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSENEQPASNQGQS 180
            E + V+SPEH +RLWGR  +SGRSSCLSSR+NS LTLTDTEHEN   +E + P   Q  +
Sbjct: 118  EADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHEN---TETDHPGGLQNHA 174

Query: 181  TLQPLPP--SHKQHSAQHHP-SITSLNRNSLTNRRNQSPAPPA-ALPAELQT--TPESVQ 234
             L+  PP  SH     QHH  SI SLNR + T R N SPAP   +L  E       E   
Sbjct: 175  RLRTPPPPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAH 234

Query: 235  LQDSWVLGSNVPLESR---------------------------------HFLFKTGTGTT 261
             Q++W+L SN+PLE+R                                 HFLFK G GT+
Sbjct: 235  AQENWLLNSNIPLETRNLGKQPFLGTLQDNLIEMDILGASRHDGAYSDGHFLFKPG-GTS 293

Query: 262  PLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLL 321
            PLF T +PGY + S +VYSPP RPLPR+T +R AF  KK SKYC+WKC AL A+ +S  L
Sbjct: 294  PLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCAALSAIVISATL 353

Query: 322  AILLSYFIAMHLFGLNWQLQQTENDTFE--NGKVNSDTMPTNTVSLPSGDNG-------- 371
             ILL+YF+AMHLFGLNW LQ  E   +E      +S  +PT+    PSG  G        
Sbjct: 354  VILLAYFVAMHLFGLNWHLQPMEGQMYEITEDTASSWPVPTDVSLYPSGGTGLETPDRKG 413

Query: 372  ------KLGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKD 425
                  K   F  E++ IDSGE+D+GRRA Q+IPPG FWRSQ+FID P  LKFN+SL K 
Sbjct: 414  KGTTEGKPSSFFPEDSFIDSGEIDVGRRASQKIPPGTFWRSQVFIDHPVHLKFNVSLGKA 473

Query: 426  ALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSLLETERAGRQARSVSLHEAGFIQY 485
            AL+G+YGRKGLPPSHTQ+DFVELLDG RL+ +E RSL  T R  R     S HE GFIQY
Sbjct: 474  ALVGIYGRKGLPPSHTQFDFVELLDGRRLLTQEARSLEGTPRQSRGTVPPSSHETGFIQY 533

Query: 486  LDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCS 545
            LDSGIWHLAFYNDGK +E VSF T  IESV  CP NC+GNG+C+SGTCHCF GFLGPDC 
Sbjct: 534  LDSGIWHLAFYNDGKESEVVSFLTTAIESVDNCPSNCYGNGDCISGTCHCFLGFLGPDCG 593

Query: 546  RAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYK 605
            RA+CPVLCSGNGQY KGRCLC SGWKG ECDVPT QCID  C   G CI G+C CN GYK
Sbjct: 594  RASCPVLCSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSNHGTCITGTCICNPGYK 653

Query: 606  GESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSC 665
            GESCEE DC+DP CS  GVC+ GECHCS GWGG+NCE  +  C DQCSGHGT+L ++G C
Sbjct: 654  GESCEEVDCMDPTCSGRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLC 713

Query: 666  TCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDG 725
            +CDP+WTG DCS EIC+ DCG HGVC+GGTCRCE+GW G AC+QRACHPRCAEHGTC+DG
Sbjct: 714  SCDPSWTGHDCSIEICAADCGGHGVCVGGTCRCEDGWMGAACDQRACHPRCAEHGTCRDG 773

Query: 726  KCECSQGWNGEHCTI---------EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVA 776
            KCECS GWNGEHCTI         EGCPGLCN NGRCTLD NGWHCVCQ GWRGAGCD +
Sbjct: 774  KCECSPGWNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCDTS 833

Query: 777  METLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKS 836
            MET C DSKDN+GDGL+DCMDPDCCLQ  C   P C G P+P DII ++    SQQ   S
Sbjct: 834  METACGDSKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQVPVSQQNLHS 893

Query: 837  FYDRISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTI 896
            FYDRI FL+G DSTH+IPGE+PF+   A VIRGQV+T+DGTPL+GVN+SF + P +GYTI
Sbjct: 894  FYDRIKFLVGRDSTHIIPGENPFDGGHACVIRGQVMTSDGTPLVGVNISFVNNPLFGYTI 953

Query: 897  TRQDGMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDL 956
            +RQDG FDLV NGG S+ L FER+PF+TQ HT+W+PW+ F+VM+T++M+ EEN+IPSCDL
Sbjct: 954  SRQDGSFDLVTNGGISIILRFERAPFITQEHTLWLPWDRFFVMETIIMRHEENEIPSCDL 1013

Query: 957  SGFVRPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKS 1016
            S F RPNP++  SPL++F  S  E  PI+PE Q L EE +I G  ++LSYLSSR  GYKS
Sbjct: 1014 SNFARPNPVVSPSPLTSFASSCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKS 1073

Query: 1017 VLKITMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSE 1076
            VL+I++T   IPFNLMKVHLMVAV GRLF+KWF A+P+L+Y FIWDKTD YNQKV+GLSE
Sbjct: 1074 VLRISLTHPTIPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKTDVYNQKVFGLSE 1133

Query: 1077 AVVSVGYEYESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGEN 1136
            A VSVGYEYESC DL LWEKRT +LQGYE+DAS +GGW+LDKHH L++Q+GIL+KGNGEN
Sbjct: 1134 AFVSVGYEYESCPDLILWEKRTTVLQGYEIDASKLGGWSLDKHHALNIQSGILHKGNGEN 1193

Query: 1137 QFISQQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRR 1196
            QF+SQQPPV+ SIMGNGRRRSISCPSCNG ADGNKLLAPVAL CG DGSLYVGDFNY+RR
Sbjct: 1194 QFVSQQPPVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTCGSDGSLYVGDFNYIRR 1253

Query: 1197 IFPSGNVTSVLEL-------SSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKD 1249
            IFPSGNVT++LEL       S +PAH+YYLATDP++G +++SD+N+RR+++ KS    KD
Sbjct: 1254 IFPSGNVTNILELRNKDFRHSHSPAHKYYLATDPMSGAVFLSDSNSRRVFKIKSTVVVKD 1313

Query: 1250 LTKNAEVVAGTGEQCLPFDEARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVD 1309
            L KN+EVVAGTG+QCLPFD+ RCGDGGKA EATL +P+G+ VDK GLIYFVDGTMIR++D
Sbjct: 1314 LVKNSEVVAGTGDQCLPFDDTRCGDGGKATEATLTNPRGITVDKFGLIYFVDGTMIRRID 1373

Query: 1310 QNGIISTLLGSNDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQIT 1369
            QNGIISTLLGSNDLTSARPL+CD+ M ISQV LEWPTDLAINPMDNS+YVLDNNVVLQI+
Sbjct: 1374 QNGIISTLLGSNDLTSARPLSCDSVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQIS 1433

Query: 1370 ENRQVRIAAGRPMHCQVPGVE-YPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINR 1428
            EN QVRI AGRPMHCQVPG++ + + K A+  TLESATA+AVS++GVLYI ETDEKKINR
Sbjct: 1434 ENHQVRIVAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEKKINR 1493

Query: 1429 IRQVTTDGEISLVAGIPSECDCKNDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIA 1488
            IRQVTT GEISLVAG PS CDCKNDANCDC+   DGYAKDAKL+ PSSLA   DG LY+A
Sbjct: 1494 IRQVTTSGEISLVAGAPSGCDCKNDANCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVA 1553

Query: 1489 DLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYS 1548
            DLGNIRIR + KNKP LN+ N YE++SP DQELY+FD  G H YT SL TGDYLYNF+Y+
Sbjct: 1554 DLGNIRIRFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTGDYLYNFTYT 1613

Query: 1549 NDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLF 1608
             D DIT +TD+NGN + +RRD   MP+ +V PD QV W+T+GTN  LKS+T QG EL + 
Sbjct: 1614 GDGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGHELAMM 1673

Query: 1609 TYHGNSGLLATKSDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSR 1668
            TYHGNSGLLATKS+E GWTTF++YDS GRLTNVTFPTG V++   D D ++ V +E+SS+
Sbjct: 1674 TYHGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSK 1733

Query: 1669 EEDVSITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTAN 1728
            + DV+IT+NLS+  +FYT++QDQ+RNSY IG DGSLR++ A+G++   QTEPH+LAGT N
Sbjct: 1734 D-DVTITTNLSASGAFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVN 1792

Query: 1729 PTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKI 1788
            PTV KRN+TLP +NG NLVEWR RKEQA+G+V VFGR+LRV+ RNLLS+DFDR T+TEKI
Sbjct: 1793 PTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKI 1852

Query: 1789 YDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGR 1848
            YDDHRKF LRI YD +G P+LW PSS+L  VNVTYS  G IA IQRG  SE+++YD  GR
Sbjct: 1853 YDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGR 1912

Query: 1849 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSI 1908
            I SR+FADGKTWSYTYLEKSMVLLLHSQRQYIFE+D  DRLS++TMP+VAR T++TIRS+
Sbjct: 1913 ITSRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSV 1972

Query: 1909 GYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSF 1968
            GYYRNIY PPE NAS+I D+ E+G LL T +LGT RRV++KY + ++L+E LYD+T+VSF
Sbjct: 1973 GYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSF 2032

Query: 1969 TYDETAGVLKTVNLQSDGFICTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVT 2028
            TYDETAG+LKT+NLQ++GF CTIRYRQIGPLIDRQIFRF+E+GMVNARFDY+YDNSFRVT
Sbjct: 2033 TYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVT 2092

Query: 2029 SMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 2088
            SMQ VINETPLPIDLY++DD+SGK EQFGKFGVIYYDINQII+TAVMT+TKHFDA+GR+K
Sbjct: 2093 SMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMK 2152

Query: 2089 EIQYEIFRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIM 2148
            E+QYEIFRSLMYW+T+QYDNMGRV K+E+K+GP+ANTT+Y+YEYD DGQLQTV +N+K +
Sbjct: 2153 EVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPL 2212

Query: 2149 WRYNYDLNGNLHLLNPSNSARLTPLRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYS 2208
            WRY+YDLNGNLHLL+P NSARLTPLRYD+RDRITRLGDVQY++DEDGFLRQRG +IFEY+
Sbjct: 2213 WRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYN 2272

Query: 2209 SKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSS 2268
            S GLL + Y++   W+V YRYDGLGRRVSSK+S   HLQFFYADLT PT++TH+YNHSSS
Sbjct: 2273 SAGLLIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSS 2332

Query: 2269 EITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDS 2328
            EITSLYYDLQGHLFAME+SSGDEFYIA DN GTPLAVFS  GLM+KQI YTAYGEIY D+
Sbjct: 2333 EITSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDT 2392

Query: 2329 NIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDIEIWKRI-GKDPAPFNLYMF 2387
            N +FQ++IG+HGGLYDPLTKL+H G RDYD+LAGRWT+PD E+WK +   +  PFNLYMF
Sbjct: 2393 NPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMF 2452

Query: 2388 RNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELV----KSQQ 2443
            +NNNP S   D+K ++TDVNSWL+TFGF LHN IPG+P P  D  EPSYEL+    K+Q+
Sbjct: 2453 KNNNPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQE 2512

Query: 2444 WDDIPPIFGVQQQVARQAKAFLSLGKMAEVQVSR-RRAGGAQSWLWFATVKSLIGKGVML 2502
            WD+   I GVQ +V +Q KAF++L +  ++  S       A     FA+  S+ GKGV  
Sbjct: 2513 WDNSKSILGVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKF 2572

Query: 2503 AVSQGRVQTNVLNIANEDCIKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTL 2562
            A+  GRV T+++++ANED  +VAA+LN+A YLENLHFTI+G DTHYF+K    E DL  L
Sbjct: 2573 ALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAIL 2632

Query: 2563 RLTSGRKALENGINVTVSQSTTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILE 2622
             L+ GR+ LENG+NVTVSQ  TV+NGRTRR+ D+++Q+GAL L+ RYG TLDEEKAR+LE
Sbjct: 2633 GLSGGRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLE 2692

Query: 2623 QARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELA 2682
             ARQRA+ +AWAREQQR+R+GEEG R WTEGEK+Q+LS G+VQGYDG++V+SVEQYPEL+
Sbjct: 2693 LARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELS 2752

Query: 2683 DSANNIQFLRQSEIGRR 2699
            DSANNI F+RQSE+GRR
Sbjct: 2753 DSANNIHFMRQSEMGRR 2769


>gi|110347400 odz, odd Oz/ten-m homolog 1 isoform 3 [Homo sapiens]
          Length = 2725

 Score = 3433 bits (8902), Expect = 0.0
 Identities = 1621/2747 (59%), Positives = 2087/2747 (75%), Gaps = 70/2747 (2%)

Query: 1    MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG 60
            M+  + +PY  L K + E +  YT+SS ++E+ R P Q SY+S ETL  ++ +  R+ Y 
Sbjct: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQ-SYNSRETLHEYNQEL-RMNYN 58

Query: 61   NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEM-GLPHRGYSISAGSDAD 119
            ++ +    +E ++ T++        +  CE +      +  +M  +   GY +  GSD D
Sbjct: 59   SQSRK--RKEVEKSTQE--------MEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVD 108

Query: 120  TENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN--------- 170
            TE E   SP+HA+R+W RG+KS  SSCLSSR+NSAL+LTDT+HE KSD EN         
Sbjct: 109  TETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCC 168

Query: 171  ----------EQPASNQGQSTLQPLPPSHKQHSA-----QHHPSITSLNRNSLTNRRNQS 215
                      +  +S   Q T +PLPP      A     +  P+  SL R S+T R   S
Sbjct: 169  DMEAQAGSTQDVQSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPS 228

Query: 216  PAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMAS 275
            PA PA   +    T +SV L +SWVL SN+PLE+RHFLFK G+G++ +FS A+  Y + S
Sbjct: 229  PAAPAPPTS----TQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTS 284

Query: 276  GSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFG 335
             +VYSPP RPLPR+T SR AF F K  + C+WKCTAL A  ++V LA+LL+Y IA+HLFG
Sbjct: 285  NTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIAVHLFG 344

Query: 336  LNWQLQQTENDTFENG--KVNSDTMPTNTVSLPSGDNGKLGGFT-----QENNTIDSGEL 388
            L WQLQ  E + + NG  K N  T   +T   P G  GK+   +     Q+   ID+GE+
Sbjct: 345  LTWQLQPVEGELYANGVSKGNRGTESMDTTYSPIG--GKVSDKSEKKVFQKGRAIDTGEV 402

Query: 389  DIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVEL 448
            DIG + +Q IPPG+FWR Q+ I  P +LKFNISL KD+L+G+YGR+ +PP+HTQ+DFV+L
Sbjct: 403  DIGAQVMQTIPPGLFWRFQITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKL 462

Query: 449  LDGSRLIAREQRSLLETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFN 508
            +DG +L+ ++ +   +T+ + R     SL E GFI+Y+D G W+LAFYNDGK  EQV   
Sbjct: 463  MDGKQLVKQDSKGSDDTQHSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVL 522

Query: 509  TIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFS 568
            T  IE + +C  NC+GNGEC+SG CHCFPGFLGPDC+R +CPVLC GNG+Y KG C+C  
Sbjct: 523  TTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRH 582

Query: 569  GWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHG 628
            GWKG ECDVP  QCIDP C G G CIMG C C  GYKGE CEE DC+DP CSNHG+C+ G
Sbjct: 583  GWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKG 642

Query: 629  ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSH 688
            ECHCS GWGG NCE    +C +QCSGHGT+L ++G C+CDP WTG DCS E+C+++CGSH
Sbjct: 643  ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSH 702

Query: 689  GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTI-------- 740
            GVC  G C+CEEGW GP C +R+CH  C EHG CKDGKCECS GW G+HCTI        
Sbjct: 703  GVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVR 762

Query: 741  EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC 800
            +GCPGLC  NGRCTLDQNGWHCVCQ GW G GC+V ME LC D+ DN+GDGL DC+DPDC
Sbjct: 763  DGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDC 822

Query: 801  CLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFN 860
            C QS+C   P C+G PDP D+I QS    SQ  ++ FYDRI FLIG DSTHVIP E  F+
Sbjct: 823  CQQSNCYISPLCQGSPDPLDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFD 882

Query: 861  KSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGASLTLVFERS 920
               A VIRGQV+  DGTPL+GVNVSF H+ +YG+TI+RQDG FDLVA GG S+ L+F+RS
Sbjct: 883  SRRACVIRGQVVAIDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRS 942

Query: 921  PFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSPE 980
            PFL +  T+W+PWN F V++ + M++  +D PSCD+S F+ PNPI++ SPL++F  S PE
Sbjct: 943  PFLPEKRTLWLPWNQFIVVEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPE 1002

Query: 981  DSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKITMTQSIIPFNLMKVHLMVAV 1040
               I+PE QV+ EE  IP + ++LSYLSSR  GYK++L+I +T S IP  ++KVHL VAV
Sbjct: 1003 RGTIVPELQVVQEEIPIPSSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAV 1062

Query: 1041 VGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLTLWEKRTAI 1100
             GRL QKWFPA+ NL YTF W+KTD Y QKV+GL+EA+VSVGYEYE+C D  LWE+RT +
Sbjct: 1063 EGRLTQKWFPAAINLVYTFAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVV 1122

Query: 1101 LQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISC 1160
            LQG+E+DASN+GGW+L+KHH+L+ Q+GI++KGNGEN FISQQPPV+S+IMGNG +RS++C
Sbjct: 1123 LQGFEMDASNLGGWSLNKHHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVAC 1182

Query: 1161 PSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLELSSNPAHRYYLA 1220
             +CNG A  NKL APVALA G DGS+YVGDFN+VRRIFPSGN  S+LELS++PAH+YYLA
Sbjct: 1183 TNCNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIFPSGNSVSILELSTSPAHKYYLA 1242

Query: 1221 TDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARCGDGGKAVE 1280
             DPV+  LY+SDTNTR++Y+ KSL   KDL+KN EVVAGTG+QCLPFD++ CGDGG+A E
Sbjct: 1243 MDPVSESLYLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASE 1302

Query: 1281 ATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSARPLTCDTSMHISQV 1340
            A+L SP+G+ VD++G IYFVDGTMIRK+D+N +I+T++GSN LTS +PL+CD+ M I+QV
Sbjct: 1303 ASLNSPRGITVDRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQV 1362

Query: 1341 RLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPGVE-YPVGKHAVQ 1399
            RLEWPTDLA+NPMDNS+YVLDNN+VLQI+ENR+VRI AGRP+HCQVPG++ + V K A+ 
Sbjct: 1363 RLEWPTDLAVNPMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIH 1422

Query: 1400 TTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKNDANCDCY 1459
            +TLESA AI+VS+SG+L+I ETDE+K+NRI+QVTT+GEI ++AG P++CDCK D NCDC+
Sbjct: 1423 STLESARAISVSHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCF 1482

Query: 1460 QSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQ 1519
                GYAKDAK+ APSSLA SPDGTLY+ADLGN+RIR +S+N+  LN MN YE+ASP DQ
Sbjct: 1483 SGDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQ 1542

Query: 1520 ELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVS 1579
            ELY F +NGTH +T++L+T DY+YNF+Y+++ D+ A+T SNGN++ IRRD   MP+ +V 
Sbjct: 1543 ELYQFTVNGTHLHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVV 1602

Query: 1580 PDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDYDSEGRLT 1639
            P  QV WLTI +NG LK ++AQG  L L TY GN+GLLATKS+E GWTT ++YD EG LT
Sbjct: 1603 PGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLT 1662

Query: 1640 NVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQLRNSYQIG 1699
            N TFPTG V++ H D++K   V++++S+R E+V +++NL++  + Y + Q+  +++Y++ 
Sbjct: 1663 NATFPTGEVSSFHSDLEKLTKVELDTSNR-ENVLMSTNLTATSTIYILKQENTQSTYRVN 1721

Query: 1700 YDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGK 1759
             DGSLR+ +ASG++    +EPH+LAG  NPT+ K N++LPGE+  NL+EWR RKEQ +G 
Sbjct: 1722 PDGSLRVTFASGMEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGN 1781

Query: 1760 VNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAV 1819
            V+ F R+LR + RNLLS+DFD  T+T KIYDDHRKF LRI YD +G P LW P S+   V
Sbjct: 1782 VSAFERRLRAHNRNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEV 1841

Query: 1820 NVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLLLHSQRQY 1879
            N+TYS +G +  IQRGT +EK++YD  G+I+SR +ADGK WSYTYLEKS++LLLHSQR+Y
Sbjct: 1842 NITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRY 1901

Query: 1880 IFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAF 1939
            IFEYD  D L ++TMPS+ RH++QT+ S+GYYRNIY PP+S+ S I DY+ +G LLQT  
Sbjct: 1902 IFEYDQPDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLH 1961

Query: 1940 LGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIRYRQIGPL 1999
            LGT RRVL+KY +Q RLSE+LYD+T+V+ TY+E++GV+KT++L  DGFICTIRYRQ GPL
Sbjct: 1962 LGTGRRVLYKYTKQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPL 2021

Query: 2000 IDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKF 2059
            I RQIFRFSE+G+VNARFDYSY N+FRVTSMQ VINETPLPIDLY++ D+SG+ EQFGKF
Sbjct: 2022 IGRQIFRFSEEGLVNARFDYSY-NNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKF 2080

Query: 2060 GVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKI 2119
             VI YD+NQ+I+T VM +TK F A+G++ E+QYEI +++ YW+TIQYDN+GR+   +I++
Sbjct: 2081 SVINYDLNQVITTTVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRV 2140

Query: 2120 GPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTPLRYDLRD 2179
            G  AN T+Y YEYD DGQLQTV +N+K  WRY+YDLNGN++LL+   SARLTPLRYDLRD
Sbjct: 2141 GVDANITRYFYEYDADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRD 2200

Query: 2180 RITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSK 2239
            RITRLG++QY++DEDGFLRQRG +IFEY+S GLL + Y+K SGWTV Y YDGLGRRV+SK
Sbjct: 2201 RITRLGEIQYKMDEDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASK 2260

Query: 2240 TSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNT 2299
            +SLGQHLQFFYADLT P R+TH+YNH+SSEITSLYYDLQGHL AME+SSG+E+Y+A DNT
Sbjct: 2261 SSLGQHLQFFYADLTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNT 2320

Query: 2300 GTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDI 2359
            GTPLAVFSS G ++K+I YT YG+IY D+  DFQ++IGFHGGLYD LTKL+H G+RDYD+
Sbjct: 2321 GTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDV 2380

Query: 2360 LAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHN 2419
            +AGRWTTP+  IWK++   P PFNLY F NN P  KI DV  Y TD+ SWL  FGF LHN
Sbjct: 2381 VAGRWTTPNHHIWKQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHN 2440

Query: 2420 AIPGFPVPKFDLTEPSYELV----KSQQWDDIPPIFGVQQQVARQAKAFLSLGKM---AE 2472
             +PGFP P+ +  E +YEL+    K+Q+WD    I G+Q ++ +Q + F+SL ++     
Sbjct: 2441 VLPGFPKPELENLELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPR 2500

Query: 2473 VQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVAAVLNNAF 2532
                R   GG Q    FA V S+ GKG+  A+  G V  +++ +ANED  ++AA+LNNA 
Sbjct: 2501 YNDGRCLEGGKQP--RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAH 2558

Query: 2533 YLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTVVNGRTRR 2592
            YLENLHFTIEG+DTHYFIK  + E DL  +  T GR+ LENG+NVTVSQ T+V+NGRTRR
Sbjct: 2559 YLENLHFTIEGRDTHYFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRR 2618

Query: 2593 FADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEEGARLWTE 2652
            FAD+++Q GAL  ++RYG T++EEK  +LE ARQRA+A+AW +EQ+R+++GEEG R WTE
Sbjct: 2619 FADIQLQHGALCFNIRYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTE 2678

Query: 2653 GEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR 2699
            GEK+QLLS G+VQGYDGY+VLSVEQY EL+DSANNI F+RQSEIGRR
Sbjct: 2679 GEKQQLLSTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2725


>gi|253970444 odz, odd Oz/ten-m homolog 1 isoform 1 [Homo sapiens]
          Length = 2732

 Score = 3426 bits (8884), Expect = 0.0
 Identities = 1621/2754 (58%), Positives = 2087/2754 (75%), Gaps = 77/2754 (2%)

Query: 1    MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG 60
            M+  + +PY  L K + E +  YT+SS ++E+ R P Q SY+S ETL  ++ +  R+ Y 
Sbjct: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQ-SYNSRETLHEYNQEL-RMNYN 58

Query: 61   NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEM-GLPHRGYSISAGSDAD 119
            ++ +    +E ++ T++        +  CE +      +  +M  +   GY +  GSD D
Sbjct: 59   SQSRK--RKEVEKSTQE--------MEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVD 108

Query: 120  TENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN--------- 170
            TE E   SP+HA+R+W RG+KS  SSCLSSR+NSAL+LTDT+HE KSD EN         
Sbjct: 109  TETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCC 168

Query: 171  ----------EQPASNQGQSTLQPLPPSHKQHSA-----QHHPSITSLNRNSLTNRRNQS 215
                      +  +S   Q T +PLPP      A     +  P+  SL R S+T R   S
Sbjct: 169  DMEAQAGSTQDVQSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPS 228

Query: 216  PAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMAS 275
            PA PA   +    T +SV L +SWVL SN+PLE+RHFLFK G+G++ +FS A+  Y + S
Sbjct: 229  PAAPAPPTS----TQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTS 284

Query: 276  GSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFG 335
             +VYSPP RPLPR+T SR AF F K  + C+WKCTAL A  ++V LA+LL+Y IA+HLFG
Sbjct: 285  NTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIAVHLFG 344

Query: 336  LNWQLQQTENDTFENG--KVNSDTMPTNTVSLPSGDNGKLGGFT-----QENNTIDSGEL 388
            L WQLQ  E + + NG  K N  T   +T   P G  GK+   +     Q+   ID+GE+
Sbjct: 345  LTWQLQPVEGELYANGVSKGNRGTESMDTTYSPIG--GKVSDKSEKKVFQKGRAIDTGEV 402

Query: 389  DIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVEL 448
            DIG + +Q IPPG+FWR Q+ I  P +LKFNISL KD+L+G+YGR+ +PP+HTQ+DFV+L
Sbjct: 403  DIGAQVMQTIPPGLFWRFQITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKL 462

Query: 449  LDGSRLIAREQRSLLETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFN 508
            +DG +L+ ++ +   +T+ + R     SL E GFI+Y+D G W+LAFYNDGK  EQV   
Sbjct: 463  MDGKQLVKQDSKGSDDTQHSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVL 522

Query: 509  TIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFS 568
            T  IE + +C  NC+GNGEC+SG CHCFPGFLGPDC+R +CPVLC GNG+Y KG C+C  
Sbjct: 523  TTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRH 582

Query: 569  GWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHG 628
            GWKG ECDVP  QCIDP C G G CIMG C C  GYKGE CEE DC+DP CSNHG+C+ G
Sbjct: 583  GWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKG 642

Query: 629  ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSH 688
            ECHCS GWGG NCE    +C +QCSGHGT+L ++G C+CDP WTG DCS E+C+++CGSH
Sbjct: 643  ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSH 702

Query: 689  GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTI-------- 740
            GVC  G C+CEEGW GP C +R+CH  C EHG CKDGKCECS GW G+HCTI        
Sbjct: 703  GVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVR 762

Query: 741  EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC 800
            +GCPGLC  NGRCTLDQNGWHCVCQ GW G GC+V ME LC D+ DN+GDGL DC+DPDC
Sbjct: 763  DGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDC 822

Query: 801  CLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFN 860
            C QS+C   P C+G PDP D+I QS    SQ  ++ FYDRI FLIG DSTHVIP E  F+
Sbjct: 823  CQQSNCYISPLCQGSPDPLDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFD 882

Query: 861  KSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGASLTLVFERS 920
               A VIRGQV+  DGTPL+GVNVSF H+ +YG+TI+RQDG FDLVA GG S+ L+F+RS
Sbjct: 883  SRRACVIRGQVVAIDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRS 942

Query: 921  PFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSPE 980
            PFL +  T+W+PWN F V++ + M++  +D PSCD+S F+ PNPI++ SPL++F  S PE
Sbjct: 943  PFLPEKRTLWLPWNQFIVVEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPE 1002

Query: 981  DSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKITMTQSIIPFNLMKVHLMVAV 1040
               I+PE QV+ EE  IP + ++LSYLSSR  GYK++L+I +T S IP  ++KVHL VAV
Sbjct: 1003 RGTIVPELQVVQEEIPIPSSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAV 1062

Query: 1041 VGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLTLWEKRTAI 1100
             GRL QKWFPA+ NL YTF W+KTD Y QKV+GL+EA+VSVGYEYE+C D  LWE+RT +
Sbjct: 1063 EGRLTQKWFPAAINLVYTFAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVV 1122

Query: 1101 LQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISC 1160
            LQG+E+DASN+GGW+L+KHH+L+ Q+GI++KGNGEN FISQQPPV+S+IMGNG +RS++C
Sbjct: 1123 LQGFEMDASNLGGWSLNKHHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVAC 1182

Query: 1161 PSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLEL-------SSNP 1213
             +CNG A  NKL APVALA G DGS+YVGDFN+VRRIFPSGN  S+LEL       S++P
Sbjct: 1183 TNCNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSP 1242

Query: 1214 AHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARCG 1273
            AH+YYLA DPV+  LY+SDTNTR++Y+ KSL   KDL+KN EVVAGTG+QCLPFD++ CG
Sbjct: 1243 AHKYYLAMDPVSESLYLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCG 1302

Query: 1274 DGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSARPLTCDT 1333
            DGG+A EA+L SP+G+ VD++G IYFVDGTMIRK+D+N +I+T++GSN LTS +PL+CD+
Sbjct: 1303 DGGRASEASLNSPRGITVDRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDS 1362

Query: 1334 SMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPGVE-YP 1392
             M I+QVRLEWPTDLA+NPMDNS+YVLDNN+VLQI+ENR+VRI AGRP+HCQVPG++ + 
Sbjct: 1363 GMDITQVRLEWPTDLAVNPMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFL 1422

Query: 1393 VGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKN 1452
            V K A+ +TLESA AI+VS+SG+L+I ETDE+K+NRI+QVTT+GEI ++AG P++CDCK 
Sbjct: 1423 VSKVAIHSTLESARAISVSHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKI 1482

Query: 1453 DANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYE 1512
            D NCDC+    GYAKDAK+ APSSLA SPDGTLY+ADLGN+RIR +S+N+  LN MN YE
Sbjct: 1483 DPNCDCFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYE 1542

Query: 1513 VASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNR 1572
            +ASP DQELY F +NGTH +T++L+T DY+YNF+Y+++ D+ A+T SNGN++ IRRD   
Sbjct: 1543 IASPADQELYQFTVNGTHLHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGG 1602

Query: 1573 MPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDY 1632
            MP+ +V P  QV WLTI +NG LK ++AQG  L L TY GN+GLLATKS+E GWTT ++Y
Sbjct: 1603 MPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEY 1662

Query: 1633 DSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQL 1692
            D EG LTN TFPTG V++ H D++K   V++++S+R E+V +++NL++  + Y + Q+  
Sbjct: 1663 DPEGHLTNATFPTGEVSSFHSDLEKLTKVELDTSNR-ENVLMSTNLTATSTIYILKQENT 1721

Query: 1693 RNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFR 1752
            +++Y++  DGSLR+ +ASG++    +EPH+LAG  NPT+ K N++LPGE+  NL+EWR R
Sbjct: 1722 QSTYRVNPDGSLRVTFASGMEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQR 1781

Query: 1753 KEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLP 1812
            KEQ +G V+ F R+LR + RNLLS+DFD  T+T KIYDDHRKF LRI YD +G P LW P
Sbjct: 1782 KEQNKGNVSAFERRLRAHNRNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSP 1841

Query: 1813 SSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLL 1872
             S+   VN+TYS +G +  IQRGT +EK++YD  G+I+SR +ADGK WSYTYLEKS++LL
Sbjct: 1842 VSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLL 1901

Query: 1873 LHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEG 1932
            LHSQR+YIFEYD  D L ++TMPS+ RH++QT+ S+GYYRNIY PP+S+ S I DY+ +G
Sbjct: 1902 LHSQRRYIFEYDQPDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDG 1961

Query: 1933 LLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIR 1992
             LLQT  LGT RRVL+KY +Q RLSE+LYD+T+V+ TY+E++GV+KT++L  DGFICTIR
Sbjct: 1962 RLLQTLHLGTGRRVLYKYTKQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIR 2021

Query: 1993 YRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGK 2052
            YRQ GPLI RQIFRFSE+G+VNARFDYSY N+FRVTSMQ VINETPLPIDLY++ D+SG+
Sbjct: 2022 YRQTGPLIGRQIFRFSEEGLVNARFDYSY-NNFRVTSMQAVINETPLPIDLYRYVDVSGR 2080

Query: 2053 VEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRV 2112
             EQFGKF VI YD+NQ+I+T VM +TK F A+G++ E+QYEI +++ YW+TIQYDN+GR+
Sbjct: 2081 TEQFGKFSVINYDLNQVITTTVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRM 2140

Query: 2113 TKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTP 2172
               +I++G  AN T+Y YEYD DGQLQTV +N+K  WRY+YDLNGN++LL+   SARLTP
Sbjct: 2141 VICDIRVGVDANITRYFYEYDADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTP 2200

Query: 2173 LRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGL 2232
            LRYDLRDRITRLG++QY++DEDGFLRQRG +IFEY+S GLL + Y+K SGWTV Y YDGL
Sbjct: 2201 LRYDLRDRITRLGEIQYKMDEDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGL 2260

Query: 2233 GRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEF 2292
            GRRV+SK+SLGQHLQFFYADLT P R+TH+YNH+SSEITSLYYDLQGHL AME+SSG+E+
Sbjct: 2261 GRRVASKSSLGQHLQFFYADLTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEY 2320

Query: 2293 YIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHF 2352
            Y+A DNTGTPLAVFSS G ++K+I YT YG+IY D+  DFQ++IGFHGGLYD LTKL+H 
Sbjct: 2321 YVACDNTGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHL 2380

Query: 2353 GERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVT 2412
            G+RDYD++AGRWTTP+  IWK++   P PFNLY F NN P  KI DV  Y TD+ SWL  
Sbjct: 2381 GQRDYDVVAGRWTTPNHHIWKQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLEL 2440

Query: 2413 FGFHLHNAIPGFPVPKFDLTEPSYELV----KSQQWDDIPPIFGVQQQVARQAKAFLSLG 2468
            FGF LHN +PGFP P+ +  E +YEL+    K+Q+WD    I G+Q ++ +Q + F+SL 
Sbjct: 2441 FGFQLHNVLPGFPKPELENLELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLD 2500

Query: 2469 KM---AEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVA 2525
            ++         R   GG Q    FA V S+ GKG+  A+  G V  +++ +ANED  ++A
Sbjct: 2501 QLPMTPRYNDGRCLEGGKQP--RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLA 2558

Query: 2526 AVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTV 2585
            A+LNNA YLENLHFTIEG+DTHYFIK  + E DL  +  T GR+ LENG+NVTVSQ T+V
Sbjct: 2559 AILNNAHYLENLHFTIEGRDTHYFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSV 2618

Query: 2586 VNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEE 2645
            +NGRTRRFAD+++Q GAL  ++RYG T++EEK  +LE ARQRA+A+AW +EQ+R+++GEE
Sbjct: 2619 LNGRTRRFADIQLQHGALCFNIRYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEE 2678

Query: 2646 GARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR 2699
            G R WTEGEK+QLLS G+VQGYDGY+VLSVEQY EL+DSANNI F+RQSEIGRR
Sbjct: 2679 GIRAWTEGEKQQLLSTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2732


>gi|253970446 odz, odd Oz/ten-m homolog 1 isoform 2 [Homo sapiens]
          Length = 2731

 Score = 3420 bits (8868), Expect = 0.0
 Identities = 1620/2754 (58%), Positives = 2086/2754 (75%), Gaps = 78/2754 (2%)

Query: 1    MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG 60
            M+  + +PY  L K + E +  YT+SS ++E+ R P Q SY+S ETL  ++ +  R+ Y 
Sbjct: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQ-SYNSRETLHEYNQEL-RMNYN 58

Query: 61   NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEM-GLPHRGYSISAGSDAD 119
            ++ +    +E ++ T++        +  CE +      +  +M  +   GY +  GSD D
Sbjct: 59   SQSRK--RKEVEKSTQE--------MEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVD 108

Query: 120  TENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN--------- 170
            TE E   SP+HA+R+W RG+KS  SSCLSSR+NSAL+LTDT+HE KSD EN         
Sbjct: 109  TETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCC 168

Query: 171  ----------EQPASNQGQSTLQPLPPSHKQHSA-----QHHPSITSLNRNSLTNRRNQS 215
                      +  +S   Q T +PLPP      A     +  P+  SL R S+T R   S
Sbjct: 169  DMEAQAGSTQDVQSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPS 228

Query: 216  PAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMAS 275
            PA PA   +    T +SV L +SWVL SN+PLE+RHFLFK G+G++ +FS A+  Y + S
Sbjct: 229  PAAPAPPTS----TQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTS 284

Query: 276  GSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFG 335
             +VYSPP RPLPR+T SR AF F K  + C+WKCTAL A  ++V LA+LL+Y I +HLFG
Sbjct: 285  NTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVI-VHLFG 343

Query: 336  LNWQLQQTENDTFENG--KVNSDTMPTNTVSLPSGDNGKLGGFT-----QENNTIDSGEL 388
            L WQLQ  E + + NG  K N  T   +T   P G  GK+   +     Q+   ID+GE+
Sbjct: 344  LTWQLQPVEGELYANGVSKGNRGTESMDTTYSPIG--GKVSDKSEKKVFQKGRAIDTGEV 401

Query: 389  DIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVEL 448
            DIG + +Q IPPG+FWR Q+ I  P +LKFNISL KD+L+G+YGR+ +PP+HTQ+DFV+L
Sbjct: 402  DIGAQVMQTIPPGLFWRFQITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKL 461

Query: 449  LDGSRLIAREQRSLLETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFN 508
            +DG +L+ ++ +   +T+ + R     SL E GFI+Y+D G W+LAFYNDGK  EQV   
Sbjct: 462  MDGKQLVKQDSKGSDDTQHSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVL 521

Query: 509  TIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFS 568
            T  IE + +C  NC+GNGEC+SG CHCFPGFLGPDC+R +CPVLC GNG+Y KG C+C  
Sbjct: 522  TTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRH 581

Query: 569  GWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHG 628
            GWKG ECDVP  QCIDP C G G CIMG C C  GYKGE CEE DC+DP CSNHG+C+ G
Sbjct: 582  GWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKG 641

Query: 629  ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSH 688
            ECHCS GWGG NCE    +C +QCSGHGT+L ++G C+CDP WTG DCS E+C+++CGSH
Sbjct: 642  ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSH 701

Query: 689  GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTI-------- 740
            GVC  G C+CEEGW GP C +R+CH  C EHG CKDGKCECS GW G+HCTI        
Sbjct: 702  GVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVR 761

Query: 741  EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC 800
            +GCPGLC  NGRCTLDQNGWHCVCQ GW G GC+V ME LC D+ DN+GDGL DC+DPDC
Sbjct: 762  DGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDC 821

Query: 801  CLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFN 860
            C QS+C   P C+G PDP D+I QS    SQ  ++ FYDRI FLIG DSTHVIP E  F+
Sbjct: 822  CQQSNCYISPLCQGSPDPLDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFD 881

Query: 861  KSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGASLTLVFERS 920
               A VIRGQV+  DGTPL+GVNVSF H+ +YG+TI+RQDG FDLVA GG S+ L+F+RS
Sbjct: 882  SRRACVIRGQVVAIDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRS 941

Query: 921  PFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSPE 980
            PFL +  T+W+PWN F V++ + M++  +D PSCD+S F+ PNPI++ SPL++F  S PE
Sbjct: 942  PFLPEKRTLWLPWNQFIVVEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPE 1001

Query: 981  DSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKITMTQSIIPFNLMKVHLMVAV 1040
               I+PE QV+ EE  IP + ++LSYLSSR  GYK++L+I +T S IP  ++KVHL VAV
Sbjct: 1002 RGTIVPELQVVQEEIPIPSSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAV 1061

Query: 1041 VGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLTLWEKRTAI 1100
             GRL QKWFPA+ NL YTF W+KTD Y QKV+GL+EA+VSVGYEYE+C D  LWE+RT +
Sbjct: 1062 EGRLTQKWFPAAINLVYTFAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVV 1121

Query: 1101 LQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISC 1160
            LQG+E+DASN+GGW+L+KHH+L+ Q+GI++KGNGEN FISQQPPV+S+IMGNG +RS++C
Sbjct: 1122 LQGFEMDASNLGGWSLNKHHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVAC 1181

Query: 1161 PSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLEL-------SSNP 1213
             +CNG A  NKL APVALA G DGS+YVGDFN+VRRIFPSGN  S+LEL       S++P
Sbjct: 1182 TNCNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSP 1241

Query: 1214 AHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARCG 1273
            AH+YYLA DPV+  LY+SDTNTR++Y+ KSL   KDL+KN EVVAGTG+QCLPFD++ CG
Sbjct: 1242 AHKYYLAMDPVSESLYLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCG 1301

Query: 1274 DGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSARPLTCDT 1333
            DGG+A EA+L SP+G+ VD++G IYFVDGTMIRK+D+N +I+T++GSN LTS +PL+CD+
Sbjct: 1302 DGGRASEASLNSPRGITVDRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDS 1361

Query: 1334 SMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPGVE-YP 1392
             M I+QVRLEWPTDLA+NPMDNS+YVLDNN+VLQI+ENR+VRI AGRP+HCQVPG++ + 
Sbjct: 1362 GMDITQVRLEWPTDLAVNPMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFL 1421

Query: 1393 VGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKN 1452
            V K A+ +TLESA AI+VS+SG+L+I ETDE+K+NRI+QVTT+GEI ++AG P++CDCK 
Sbjct: 1422 VSKVAIHSTLESARAISVSHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKI 1481

Query: 1453 DANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYE 1512
            D NCDC+    GYAKDAK+ APSSLA SPDGTLY+ADLGN+RIR +S+N+  LN MN YE
Sbjct: 1482 DPNCDCFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYE 1541

Query: 1513 VASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNR 1572
            +ASP DQELY F +NGTH +T++L+T DY+YNF+Y+++ D+ A+T SNGN++ IRRD   
Sbjct: 1542 IASPADQELYQFTVNGTHLHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGG 1601

Query: 1573 MPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDY 1632
            MP+ +V P  QV WLTI +NG LK ++AQG  L L TY GN+GLLATKS+E GWTT ++Y
Sbjct: 1602 MPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEY 1661

Query: 1633 DSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQL 1692
            D EG LTN TFPTG V++ H D++K   V++++S+R E+V +++NL++  + Y + Q+  
Sbjct: 1662 DPEGHLTNATFPTGEVSSFHSDLEKLTKVELDTSNR-ENVLMSTNLTATSTIYILKQENT 1720

Query: 1693 RNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFR 1752
            +++Y++  DGSLR+ +ASG++    +EPH+LAG  NPT+ K N++LPGE+  NL+EWR R
Sbjct: 1721 QSTYRVNPDGSLRVTFASGMEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQR 1780

Query: 1753 KEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLP 1812
            KEQ +G V+ F R+LR + RNLLS+DFD  T+T KIYDDHRKF LRI YD +G P LW P
Sbjct: 1781 KEQNKGNVSAFERRLRAHNRNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSP 1840

Query: 1813 SSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLL 1872
             S+   VN+TYS +G +  IQRGT +EK++YD  G+I+SR +ADGK WSYTYLEKS++LL
Sbjct: 1841 VSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLL 1900

Query: 1873 LHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEG 1932
            LHSQR+YIFEYD  D L ++TMPS+ RH++QT+ S+GYYRNIY PP+S+ S I DY+ +G
Sbjct: 1901 LHSQRRYIFEYDQPDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDG 1960

Query: 1933 LLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIR 1992
             LLQT  LGT RRVL+KY +Q RLSE+LYD+T+V+ TY+E++GV+KT++L  DGFICTIR
Sbjct: 1961 RLLQTLHLGTGRRVLYKYTKQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIR 2020

Query: 1993 YRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGK 2052
            YRQ GPLI RQIFRFSE+G+VNARFDYSY N+FRVTSMQ VINETPLPIDLY++ D+SG+
Sbjct: 2021 YRQTGPLIGRQIFRFSEEGLVNARFDYSY-NNFRVTSMQAVINETPLPIDLYRYVDVSGR 2079

Query: 2053 VEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRV 2112
             EQFGKF VI YD+NQ+I+T VM +TK F A+G++ E+QYEI +++ YW+TIQYDN+GR+
Sbjct: 2080 TEQFGKFSVINYDLNQVITTTVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRM 2139

Query: 2113 TKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTP 2172
               +I++G  AN T+Y YEYD DGQLQTV +N+K  WRY+YDLNGN++LL+   SARLTP
Sbjct: 2140 VICDIRVGVDANITRYFYEYDADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTP 2199

Query: 2173 LRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGL 2232
            LRYDLRDRITRLG++QY++DEDGFLRQRG +IFEY+S GLL + Y+K SGWTV Y YDGL
Sbjct: 2200 LRYDLRDRITRLGEIQYKMDEDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGL 2259

Query: 2233 GRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEF 2292
            GRRV+SK+SLGQHLQFFYADLT P R+TH+YNH+SSEITSLYYDLQGHL AME+SSG+E+
Sbjct: 2260 GRRVASKSSLGQHLQFFYADLTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEY 2319

Query: 2293 YIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHF 2352
            Y+A DNTGTPLAVFSS G ++K+I YT YG+IY D+  DFQ++IGFHGGLYD LTKL+H 
Sbjct: 2320 YVACDNTGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHL 2379

Query: 2353 GERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVT 2412
            G+RDYD++AGRWTTP+  IWK++   P PFNLY F NN P  KI DV  Y TD+ SWL  
Sbjct: 2380 GQRDYDVVAGRWTTPNHHIWKQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLEL 2439

Query: 2413 FGFHLHNAIPGFPVPKFDLTEPSYELV----KSQQWDDIPPIFGVQQQVARQAKAFLSLG 2468
            FGF LHN +PGFP P+ +  E +YEL+    K+Q+WD    I G+Q ++ +Q + F+SL 
Sbjct: 2440 FGFQLHNVLPGFPKPELENLELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLD 2499

Query: 2469 KM---AEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVA 2525
            ++         R   GG Q    FA V S+ GKG+  A+  G V  +++ +ANED  ++A
Sbjct: 2500 QLPMTPRYNDGRCLEGGKQP--RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLA 2557

Query: 2526 AVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTV 2585
            A+LNNA YLENLHFTIEG+DTHYFIK  + E DL  +  T GR+ LENG+NVTVSQ T+V
Sbjct: 2558 AILNNAHYLENLHFTIEGRDTHYFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSV 2617

Query: 2586 VNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEE 2645
            +NGRTRRFAD+++Q GAL  ++RYG T++EEK  +LE ARQRA+A+AW +EQ+R+++GEE
Sbjct: 2618 LNGRTRRFADIQLQHGALCFNIRYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEE 2677

Query: 2646 GARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR 2699
            G R WTEGEK+QLLS G+VQGYDGY+VLSVEQY EL+DSANNI F+RQSEIGRR
Sbjct: 2678 GIRAWTEGEKQQLLSTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2731


>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
          Length = 4242

 Score =  234 bits (596), Expect = 1e-60
 Identities = 105/256 (41%), Positives = 138/256 (53%), Gaps = 12/256 (4%)

Query: 518 CPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDV 577
           CP +C+  G CV G C CFPG+ GP C   +CP  C G G+  +G C+C +G+ G +C  
Sbjct: 187 CPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDC-- 244

Query: 578 PTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWG 637
            + +     C  RG C  G C C+ GY G+ C    C   GCS  G C +G C C+PG+ 
Sbjct: 245 -SQRSCPRGCSQRGRCEGGRCVCDPGYTGDDCGMRSC-PRGCSQRGRCENGRCVCNPGYT 302

Query: 638 GSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCR 697
           G +C +    CP  CS  G    + G C CDP +TG DC    C  DCG  G C+ G C 
Sbjct: 303 GEDCGVRS--CPRGCSQRGRC--KDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVDGRCV 358

Query: 698 CEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQ 757
           C  G+TG  C+ R C   C   G C+DG+C C  G++G+ C +  CPG CN  GRC   +
Sbjct: 359 CWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRC---E 415

Query: 758 NGWHCVCQPGWRGAGC 773
           +G  CVC PG+ G  C
Sbjct: 416 DG-RCVCWPGYTGTDC 430



 Score =  231 bits (588), Expect = 1e-59
 Identities = 113/293 (38%), Positives = 144/293 (49%), Gaps = 27/293 (9%)

Query: 515 VVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           V  CP +C+  G C  G C C+PG+ G DC   ACP  C G G+   G C+C +G+ G +
Sbjct: 401 VRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVCVCNAGYSGED 460

Query: 575 CDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPG-CSNHGVCIHGECHCS 633
           C V   +     C GRG C  G C C  GY G  C    C  PG C   G C+ G C C+
Sbjct: 461 CGV---RSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRAC--PGDCRGRGRCVDGRCVCN 515

Query: 634 PGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMG 693
           PG+ G +C      CP  C GHG  L E G C CD  ++G DCS   C   C   G C+ 
Sbjct: 516 PGFTGEDCG--SRRCPGDCRGHG--LCEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQCLD 571

Query: 694 GTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRC 753
           G C CE+G++G  C  R C   C++HG C+DG C C +G+  E C+I  CP  C+  GRC
Sbjct: 572 GRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRC 631

Query: 754 TLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 806
              + G  C+C PG+ G  C   M   C            DC     C+Q  C
Sbjct: 632 ---EEG-RCLCDPGYTGPTCATRM---CP----------ADCRGRGRCVQGVC 667



 Score =  226 bits (575), Expect = 3e-58
 Identities = 118/314 (37%), Positives = 149/314 (47%), Gaps = 28/314 (8%)

Query: 518 CPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDV 577
           CP +C   G CV G C C+PG+ G DCS   CP  C G G+   G C+C +G+ G +C V
Sbjct: 342 CPWDCGEGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGV 401

Query: 578 PTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWG 637
              +     C  RG C  G C C  GY G  C    C    C   G C +G C C+ G+ 
Sbjct: 402 ---RSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRAC-PRDCRGRGRCENGVCVCNAGYS 457

Query: 638 GSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCR 697
           G +C +    CP  C G G    ESG C C P +TG DC    C  DC   G C+ G C 
Sbjct: 458 GEDCGVRS--CPGDCRGRGRC--ESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCV 513

Query: 698 CEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQ 757
           C  G+TG  C  R C   C  HG C+DG C C  G++GE C+   CPG C   G+C LD 
Sbjct: 514 CNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQC-LD- 571

Query: 758 NGWHCVCQPGWRGAGCDVAMETLCTDSKDNEG---DGLIDC----MDPDCCLQ---SSCQ 807
               CVC+ G+ G  C V     C +     G   DG+  C    +  DC ++   S+C 
Sbjct: 572 --GRCVCEDGYSGEDCGVRQ---CPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCH 626

Query: 808 NQPYC---RGLPDP 818
            +  C   R L DP
Sbjct: 627 GRGRCEEGRCLCDP 640



 Score =  221 bits (564), Expect = 6e-57
 Identities = 100/257 (38%), Positives = 126/257 (49%), Gaps = 14/257 (5%)

Query: 518 CPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDV 577
           CPR+C G G C +G C C  G+ G DC   +CP  C G G+   GRC+C+ G+ G +C  
Sbjct: 435 CPRDCRGRGRCENGVCVCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCG- 493

Query: 578 PTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPG-CSNHGVCIHGECHCSPGW 636
             T+     C GRG C+ G C CN G+ GE C    C  PG C  HG+C  G C C  G+
Sbjct: 494 --TRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRC--PGDCRGHGLCEDGVCVCDAGY 549

Query: 637 GGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTC 696
            G +C      CP  C G G  L   G C C+  ++G DC    C  DC  HGVC  G C
Sbjct: 550 SGEDCSTRS--CPGGCRGRGQCLD--GRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVC 605

Query: 697 RCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLD 756
            C EG+    C+ R C   C   G C++G+C C  G+ G  C    CP  C   GRC   
Sbjct: 606 ICWEGYVSEDCSIRTCPSNCHGRGRCEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQG 665

Query: 757 QNGWHCVCQPGWRGAGC 773
                C+C  G+ G  C
Sbjct: 666 V----CLCHVGYGGEDC 678



 Score =  216 bits (550), Expect = 2e-55
 Identities = 110/291 (37%), Positives = 139/291 (47%), Gaps = 24/291 (8%)

Query: 515 VVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           V  CP +C G G C SG C C+PG+ G DC   ACP  C G G+   GRC+C  G+ G +
Sbjct: 463 VRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGED 522

Query: 575 CDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSP 634
           C   + +C    C G G+C  G C C++GY GE C    C   GC   G C+ G C C  
Sbjct: 523 CG--SRRC-PGDCRGHGLCEDGVCVCDAGYSGEDCSTRSC-PGGCRGRGQCLDGRCVCED 578

Query: 635 GWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGG 694
           G+ G +C + +  CP+ CS HG    + G C C   +   DCS   C  +C   G C  G
Sbjct: 579 GYSGEDCGVRQ--CPNDCSQHGVC--QDGVCICWEGYVSEDCSIRTCPSNCHGRGRCEEG 634

Query: 695 TCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIE-----GCPGLCNS 749
            C C+ G+TGP C  R C   C   G C  G C C  G+ GE C  E      CPG C  
Sbjct: 635 RCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPGGCGP 694

Query: 750 NGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC 800
              C   Q    CVC  G+RG  C  A++T   D +     G  +C D  C
Sbjct: 695 RELCRAGQ----CVCVEGFRGPDC--AIQTCPGDCR-----GRGECHDGSC 734



 Score =  192 bits (488), Expect = 4e-48
 Identities = 98/266 (36%), Positives = 117/266 (43%), Gaps = 49/266 (18%)

Query: 518 CPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDV 577
           CP +C G G CV G C C PGF G DC    CP  C G+G    G C+C +G+ G +C  
Sbjct: 497 CPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGEDC-- 554

Query: 578 PTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWG 637
            +T+     C GRG C+ G C C  GY GE C    C +  CS HGVC  G C C  G+ 
Sbjct: 555 -STRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPND-CSQHGVCQDGVCICWEGYV 612

Query: 638 GSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCR 697
             +C I    CP  C G G    E G C CDP +TGP C+  +C  DC   G C+ G C 
Sbjct: 613 SEDCSI--RTCPSNCHGRGRC--EEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCL 668

Query: 698 CE------------------------------------EGWTGPACNQRACHPRCAEHGT 721
           C                                     EG+ GP C  + C   C   G 
Sbjct: 669 CHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCPGDCRGRGE 728

Query: 722 CKDGKCECSQGWNGEHC-----TIEG 742
           C DG C C  G+ GE C     TIEG
Sbjct: 729 CHDGSCVCKDGYAGEDCGEEVPTIEG 754



 Score =  185 bits (470), Expect = 5e-46
 Identities = 102/289 (35%), Positives = 122/289 (42%), Gaps = 35/289 (12%)

Query: 527 ECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCF--SGWKGTECDVPTTQCID 584
           +C  G C   P        +     LCS +G +   RC C    GW G  C  PT   I 
Sbjct: 120 QCTGGCC---PASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIP 176

Query: 585 P------------QCGGRGICIMGSCACNSGYKGESCEEADCIDPG-CSNHGVCIHGECH 631
           P             C  +G C+ G C C  GY G SC    C  PG C   G C+ G C 
Sbjct: 177 PSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSC--PGDCQGRGRCVQGVCV 234

Query: 632 CSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVC 691
           C  G+ G +C   +  CP  CS  G    E G C CDP +TG DC    C   C   G C
Sbjct: 235 CRAGFSGPDCS--QRSCPRGCSQRGRC--EGGRCVCDPGYTGDDCGMRSCPRGCSQRGRC 290

Query: 692 MGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNG 751
             G C C  G+TG  C  R+C   C++ G CKDG+C C  G+ GE C    CP  C   G
Sbjct: 291 ENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGG 350

Query: 752 RCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC 800
           RC        CVC PG+ G  C        T  +D  G G   C D +C
Sbjct: 351 RCV----DGRCVCWPGYTGEDCSTR-----TCPRDCRGRG--RCEDGEC 388



 Score =  151 bits (381), Expect = 1e-35
 Identities = 71/199 (35%), Positives = 95/199 (47%), Gaps = 9/199 (4%)

Query: 514 SVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGT 573
           S   CP  C G G+C+ G C C  G+ G DC    CP  CS +G    G C+C+ G+   
Sbjct: 555 STRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSE 614

Query: 574 ECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCS 633
           +C + T       C GRG C  G C C+ GY G +C    C    C   G C+ G C C 
Sbjct: 615 DCSIRT---CPSNCHGRGRCEEGRCLCDPGYTGPTCATRMC-PADCRGRGRCVQGVCLCH 670

Query: 634 PGWGGSNC---EILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGV 690
            G+GG +C   E   + CP  C      L  +G C C   + GPDC+ + C  DC   G 
Sbjct: 671 VGYGGEDCGQEEPPASACPGGCGPR--ELCRAGQCVCVEGFRGPDCAIQTCPGDCRGRGE 728

Query: 691 CMGGTCRCEEGWTGPACNQ 709
           C  G+C C++G+ G  C +
Sbjct: 729 CHDGSCVCKDGYAGEDCGE 747


>gi|153946395 tenascin C precursor [Homo sapiens]
          Length = 2201

 Score =  233 bits (595), Expect = 1e-60
 Identities = 115/309 (37%), Positives = 158/309 (51%), Gaps = 24/309 (7%)

Query: 514 SVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSG-NGQYSKGRCLCFSGWKG 572
           S + CP +C+  G+CV+G C CF G+ G DCSR  CPV CS  +G    G C+C  G+ G
Sbjct: 217 SQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAG 276

Query: 573 TECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHC 632
            +C+ P   C++  C  RG C+   C C+ G+ GE C E  C +  C + G CI+G C+C
Sbjct: 277 DDCNKPL--CLN-NCYNRGRCVENECVCDEGFTGEDCSELICPND-CFDRGRCINGTCYC 332

Query: 633 SPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCM 692
             G+ G +C   K  CP  C   G    E G C CD  + G DCS + C  DC + G C+
Sbjct: 333 EEGFTGEDCG--KPTCPHACHTQGRC--EEGQCVCDEGFAGVDCSEKRCPADCHNRGRCV 388

Query: 693 GGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGR 752
            G C C++G+TG  C +  C   C+ HG C +G+C C +G+ GE C+   CP  C+S GR
Sbjct: 389 DGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGR 448

Query: 753 CTLDQNGWHCVCQPGWRGAGC-------DVAMETLCTDSKDNEGDGLI--DCMDPDCCLQ 803
           C   +    CVC+ G++G  C       D      C +      DG    DC D  C   
Sbjct: 449 CVEGK----CVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQC--P 502

Query: 804 SSCQNQPYC 812
             C N+  C
Sbjct: 503 RDCSNRGLC 511



 Score =  224 bits (570), Expect = 1e-57
 Identities = 107/334 (32%), Positives = 158/334 (47%), Gaps = 47/334 (14%)

Query: 518 CPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDV 577
           CP +C   G C++GTC+C  GF G DC +  CP  C   G+  +G+C+C  G+ G +C  
Sbjct: 315 CPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCS- 373

Query: 578 PTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWG 637
              +C    C  RG C+ G C C+ G+ G  C E  C + GCS HG C++G+C C  G+ 
Sbjct: 374 -EKRC-PADCHNRGRCVDGRCECDDGFTGADCGELKCPN-GCSGHGRCVNGQCVCDEGYT 430

Query: 638 GSNCEILKT-----------------------------MCPDQCSGHGTYLQESGSCTCD 668
           G +C  L+                               CP+ C  HG  +  +G C CD
Sbjct: 431 GEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCV--NGMCVCD 488

Query: 669 PNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCE 728
             +TG DC +  C  DC + G+C+ G C CE+G+TGP C + +C   C   G C +G+C 
Sbjct: 489 DGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCV 548

Query: 729 CSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNE 788
           C +G+ G+ C  + CP  C+  GRC   Q    C+C  G+ G  C    +  C    +N 
Sbjct: 549 CHEGFMGKDCKEQRCPSDCHGQGRCVDGQ----CICHEGFTGLDCG---QHSCPSDCNNL 601

Query: 789 GDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDII 822
           G     C+   C        +  C  +  P+D++
Sbjct: 602 G----QCVSGRCICNEGYSGED-CSEVSPPKDLV 630



 Score =  201 bits (512), Expect = 6e-51
 Identities = 103/305 (33%), Positives = 139/305 (45%), Gaps = 30/305 (9%)

Query: 522 CHGNGECVSGTCHCF--PGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPT 579
           C G G   +  C C   PG+ GP+CS   CP  C   G+   G+C+C  G+ G +C   +
Sbjct: 161 CSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDC---S 217

Query: 580 TQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGS 639
                  C  +G C+ G C C  GY G  C    C  P    HG C+ G C C  G+ G 
Sbjct: 218 QLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGD 277

Query: 640 NCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCE 699
           +C   K +C + C   G  ++    C CD  +TG DCS  IC  DC   G C+ GTC CE
Sbjct: 278 DCN--KPLCLNNCYNRGRCVE--NECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCE 333

Query: 700 EGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNG 759
           EG+TG  C +  C   C   G C++G+C C +G+ G  C+ + CP  C++ GRC      
Sbjct: 334 EGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCV----D 389

Query: 760 WHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC----------CLQSSCQNQ 809
             C C  G+ GA C    E  C +     G     C++  C          C Q  C N 
Sbjct: 390 GRCECDDGFTGADCG---ELKCPNGCSGHG----RCVNGQCVCDEGYTGEDCSQLRCPND 442

Query: 810 PYCRG 814
            + RG
Sbjct: 443 CHSRG 447



 Score =  129 bits (324), Expect = 4e-29
 Identities = 60/164 (36%), Positives = 86/164 (52%), Gaps = 8/164 (4%)

Query: 514 SVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGT 573
           S + CP +CH +G CV+G C C  G+ G DC    CP  CS  G    G+C+C  G+ G 
Sbjct: 466 SDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGP 525

Query: 574 ECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCS 633
           +C      C +  C G+G C+ G C C+ G+ G+ C+E  C    C   G C+ G+C C 
Sbjct: 526 DC--AELSCPN-DCHGQGRCVNGQCVCHEGFMGKDCKEQRC-PSDCHGQGRCVDGQCICH 581

Query: 634 PGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCS 677
            G+ G +C   +  CP  C+  G  +  SG C C+  ++G DCS
Sbjct: 582 EGFTGLDCG--QHSCPSDCNNLGQCV--SGRCICNEGYSGEDCS 621



 Score =  101 bits (252), Expect = 9e-21
 Identities = 40/96 (41%), Positives = 50/96 (52%), Gaps = 3/96 (3%)

Query: 516 VECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTEC 575
           + CP +CHG G CV+G C C  GF+G DC    CP  C G G+   G+C+C  G+ G +C
Sbjct: 530 LSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDC 589

Query: 576 DVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEE 611
                      C   G C+ G C CN GY GE C E
Sbjct: 590 G---QHSCPSDCNNLGQCVSGRCICNEGYSGEDCSE 622


>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
           sapiens]
          Length = 1037

 Score =  157 bits (396), Expect = 2e-37
 Identities = 103/352 (29%), Positives = 134/352 (38%), Gaps = 98/352 (27%)

Query: 518 CPRNCHGNG-------------ECVSGTCHCFPGFLGPDCSRAA--------CPVLCSGN 556
           CP++ HG G             +  SG C C PG+ GP C+           C   CS  
Sbjct: 395 CPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCE 454

Query: 557 GQYS----KGRCLCFSGWKGTECDVPTT------QC-IDPQCGGRGICI--MGSCACNSG 603
              +     G C+C  GW+   C VP         C    QC    +C    G+C C  G
Sbjct: 455 NAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPG 514

Query: 604 YKGESCE---EADCIDPGCSNHGVC--------IHGECHCSPGWGGSNCEILKTMCPD-- 650
           + G  C+          GC++   C        +HG C C  GW G+ C +    CP+  
Sbjct: 515 WHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHL---SCPEGL 571

Query: 651 ---------QCSGHGTYLQESGSCTCDPNWTGPDC---------SNEICSVDCGSHGVC- 691
                     C   GT L E+G+C C P + GP C                 C +H  C 
Sbjct: 572 WGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCH 631

Query: 692 -MGGTCRCEEGWTGPACNQRACHP-----------RCAEHGTC--KDGKCECSQGWNGEH 737
              GTC C  GWTGP C+Q  C P           +C   GTC  +DG C C  GW G H
Sbjct: 632 PSNGTCYCLAGWTGPDCSQ-PCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHH 690

Query: 738 CTIEGC-----------PGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAME 778
           C +EGC           P  C    +C  +     CVC PG  GA C + ++
Sbjct: 691 C-LEGCPLGTFGANCSQPCQCGPGEKCHPETGA--CVCPPGHSGAPCRIGIQ 739



 Score =  127 bits (320), Expect = 1e-28
 Identities = 94/320 (29%), Positives = 122/320 (38%), Gaps = 88/320 (27%)

Query: 517 ECPRNCHGNGEC--VSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           EC   CH  G C   +G C C PG+ G  C R  CPV     GQ     C C        
Sbjct: 275 EC--RCHNGGLCDRFTGQCRCAPGYTGDRC-REECPV--GRFGQDCAETCDC-------- 321

Query: 575 CDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDP--GCSNHGVC------- 625
              P  +C             G+C C  G+ G+ C +  C D   G S    C       
Sbjct: 322 --APDARCFPAN---------GACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHS 370

Query: 626 -----IHGECHCSPGWGGSNCEILKTMCPDQCSG----------HGTYLQ-ESGSCTCDP 669
                ++GEC C PGW G +C      CP    G          HG   Q  SG C C P
Sbjct: 371 LSCHPMNGECSCLPGWAGLHC---NESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAP 427

Query: 670 NWTGPDCSN----EICSVDCGSHGVC--------MGGTCRCEEGWTGPACNQRACHP--- 714
            +TGP C++    +   V+C +   C        + G C C+EGW    C+   C P   
Sbjct: 428 GYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSV-PCPPGTW 486

Query: 715 --------RCAEHGTC--KDGKCECSQGWNGEHCTI--------EGCPGLCNSNGRCTLD 756
                   +CA    C  + G C C+ GW+G HC +        EGC   C+ +     D
Sbjct: 487 GFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCD 546

Query: 757 QNGWHCVCQPGWRGAGCDVA 776
                C CQ GW GA C ++
Sbjct: 547 PVHGRCQCQAGWMGARCHLS 566



 Score =  115 bits (287), Expect = 8e-25
 Identities = 106/378 (28%), Positives = 130/378 (34%), Gaps = 106/378 (28%)

Query: 518 CPRNCHGNGECVS-GTCHCFPGFLGPDCSRAACPVL----------CSGNGQY--SKGRC 564
           C + C  +G CV+   C C PG+ G DCS    P +          C  N       G C
Sbjct: 105 CAQECV-HGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVC 163

Query: 565 LCFSGWKGTECDVPTTQ-CIDPQCGGRGIC-------IMGSCACNSGYKGESCEEADCID 616
            C SG +   C  P T     P C  R  C         G+C C +   G SC +  C  
Sbjct: 164 SCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSC-DVSCSQ 222

Query: 617 ----------PGCSNHGV--CIHGECHCSPGWGGSNCEILKTMCPD-----------QCS 653
                       C N GV     G C C PGW G+ C +    CP+           +C 
Sbjct: 223 GTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSL---PCPEGFHGPNCSQECRCH 279

Query: 654 GHGTYLQESGSCTCDPNWTGPDCSNEICSV-----------DCGSHGVCM--GGTCRCEE 700
             G   + +G C C P +TG  C  E C V           DC     C    G C CE 
Sbjct: 280 NGGLCDRFTGQCRCAPGYTGDRCREE-CPVGRFGQDCAETCDCAPDARCFPANGACLCEH 338

Query: 701 GWTGPACNQRACHP-----RCAEHGTC----------KDGKCECSQGWNGEHCTIEGCPG 745
           G+TG  C  R C        C    TC           +G+C C  GW G HC  E CP 
Sbjct: 339 GFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCN-ESCPQ 397

Query: 746 -----------LCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLID 794
                      LC   G C        C C PG+ G  C     +LC            D
Sbjct: 398 DTHGPGCQEHCLCLHGGVC--QATSGLCQCAPGYTGPHC----ASLCPP----------D 441

Query: 795 CMDPDCCLQSSCQNQPYC 812
               +C  + SC+N   C
Sbjct: 442 TYGVNCSARCSCENAIAC 459



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 17/83 (20%)

Query: 701 GWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGL----------CNSN 750
           G+  P C Q   H RC         +C+C  GW G+ C+ E  PG+          C +N
Sbjct: 99  GFCVPLCAQECVHGRCVA-----PNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNN 153

Query: 751 GRCTLDQNGWHCVCQPGWRGAGC 773
             C  D     C C  G +   C
Sbjct: 154 SSC--DPKSGVCSCPSGLQPPNC 174


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  154 bits (390), Expect = 9e-37
 Identities = 105/347 (30%), Positives = 146/347 (42%), Gaps = 52/347 (14%)

Query: 514  SVVECPRN-CHGNGEC---VSG-TCHCFPGFLGPDCSRAACP---------VLCSGNGQY 559
            ++ EC  N C   G C   +SG TCHC   + G +C     P          +C  +  +
Sbjct: 795  NIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNF 854

Query: 560  SKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGIC--IMGS--CACNSGYKGESCEE--AD 613
                CLC  GW+G  C +   +CI   C   G+C    GS  C C  G+ G  CEE   D
Sbjct: 855  ESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDD 914

Query: 614  CIDPGCSNHGVCIHG----ECHCSPGWGGSNCEILKTMC-PDQCSGHGTYLQ--ESGSCT 666
            C+   C N G C+ G     C C PG+ G  C+     C  + C   GT      S +C 
Sbjct: 915  CLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCK 974

Query: 667  CDPNWTGPDCS---NEICSVDCGSHGVCMGG----TCRCEEGWTGPAC----NQRACHPR 715
            C   + G  C    NE     C + G C+ G    +C C  G+TG  C    N+ + HP 
Sbjct: 975  CQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHP- 1033

Query: 716  CAEHGTCKDG----KCECSQGWNGEHC--TIEGCP-GLCNSNGRCTLDQNGWHCVCQPGW 768
            C   GTC DG    +C C  G+ G++C   +  C    C + G C   +    C+C  GW
Sbjct: 1034 CLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGW 1093

Query: 769  RGAGCDVAMETLCTDSKDNEGDGLID--CMDPDCCLQSSCQNQPYCR 813
             GA CDV    +  D   +    L++  C     C+ +   N  YC+
Sbjct: 1094 AGAYCDV--PNVSCDIAASRRGVLVEHLCQHSGVCINAG--NTHYCQ 1136



 Score =  145 bits (367), Expect = 4e-34
 Identities = 106/358 (29%), Positives = 139/358 (38%), Gaps = 58/358 (16%)

Query: 517 ECPRN-CHGNGECVSGT----CHCFPGFLGP-------DCSRAACPVLCSGNGQYSKGRC 564
           EC  N C  NG+CV       C C PGF GP       DCS   C          +   C
Sbjct: 497 ECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYEC 556

Query: 565 LCFSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCEEA--DCIDPG 618
            C +G+ G  C+     C DP     G C  G    +C CN GY G  C +   +C    
Sbjct: 557 QCATGFTGVLCEENIDNC-DPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSP 615

Query: 619 CSNHGVCIH----GECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQ--ESGSCTCDPNWT 672
           C N G CI      +C+C PG  G NCEI    C      HG  +      SC C P +T
Sbjct: 616 CLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFT 675

Query: 673 GPDCS---NEICSVDCGSHGVCMGGT----CRCEEGWTGPACNQRA--CHPRCAEHGTCK 723
           G  C+   +E  S  C     C+ G     C C EG   P+C  +   C      HG C 
Sbjct: 676 GQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCT 735

Query: 724 DG----KCECSQGWNGEHCTI---EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVA 776
            G    KC C  GW G +C +   E     C + G C    NG+ C C+ G++G  C V 
Sbjct: 736 GGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVN 795

Query: 777 METLCTDSKDNEGDGLIDCMDPDC-----------------CLQSSCQNQPYCRGLPD 817
           ++   ++   N+G    D     C                 C  + C+N   C+  P+
Sbjct: 796 IDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPN 853



 Score =  136 bits (342), Expect = 3e-31
 Identities = 97/330 (29%), Positives = 138/330 (41%), Gaps = 46/330 (13%)

Query: 517  ECPRN-CHGNGECVSGT----CHCFPGFLGPDCSRAACPVLCS----GN--GQYSKGRCL 565
            EC  N C     C++G     C C  G   P C       L +    GN  G  S  +CL
Sbjct: 685  ECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCL 744

Query: 566  CFSGWKGTECDVPTTQCIDPQCGGRGIC---IMG-SCACNSGYKGESCEE--ADCIDPGC 619
            C +GW G  C+V   +C+   C   G C   + G  C C  G+KG +C+    +C    C
Sbjct: 745  CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPC 804

Query: 620  SNHGVCIHG----ECHCSPGWGGSNCEILKTMC-PDQCSGHGTYLQ----ESGSCTCDPN 670
             N G C        CHC   + G NC+ +   C P+ C       +    ES +C C P 
Sbjct: 805  LNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPG 864

Query: 671  WTGPDCS---NEICSVDCGSHGVCMGG----TCRCEEGWTGPACNQR----ACHPRCAEH 719
            W G  C+   +E  S  C +HG+C        C C  G++G  C +       +P C   
Sbjct: 865  WQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANP-CQNG 923

Query: 720  GTCKDG----KCECSQGWNGEHCTIEGCPGL---CNSNGRCTLDQNGWHCVCQPGWRGAG 772
            G+C DG     C C  G+ G+ C  +    L   C + G C+   N + C CQ G+ G  
Sbjct: 924  GSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVH 983

Query: 773  CDVAMETLCTDSKDNEGDGLIDCMDPDCCL 802
            C+  +   CT+S    G   +D ++   CL
Sbjct: 984  CENNINE-CTESSCFNGGTCVDGINSFSCL 1012



 Score =  135 bits (341), Expect = 4e-31
 Identities = 106/356 (29%), Positives = 134/356 (37%), Gaps = 66/356 (18%)

Query: 522 CHGNGECVS-----GTCHCFPGFLGPDCS-RAACPV-------LCSGNGQYSKGRCLCFS 568
           C   G CV+     G C C  GFLG  C  R  C          C       K  C C S
Sbjct: 35  CVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCAS 94

Query: 569 GWKGTECDVPTTQ--CIDPQCGGRGICIMGS-----CACNSGYKGESCEEAD-CIDPGCS 620
           G+ G +C   T+    +   C   G C M S     C C  G+ G+ C+  D C+   C+
Sbjct: 95  GFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCA 154

Query: 621 NHGVCI----HGECHCSPGWGGSNCEILKTMC--PDQCSGHGTYLQESGS--CTCDPNWT 672
           N   C        C C  G+ G  CE     C  P  C   GT L   GS  C C   +T
Sbjct: 155 NGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFT 214

Query: 673 GPDCSNEICSVDCGSHGVCMGGTCR----------CEEGWTGPACNQRA--C-HPRCAEH 719
           G  C +    V C       GGTCR          C  G+ G  C +    C + RC   
Sbjct: 215 GQYCDS--LYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNG 272

Query: 720 GTCKDG----KCECSQGWNGEHCT--IEGC---PGLCNSNGRCTLDQNGWHCVCQPGWRG 770
           G C DG     C C   W G+ CT  ++ C   P  C + G C     G+ CVC  GW G
Sbjct: 273 GVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSG 332

Query: 771 AGCDVAMETLCTDSKDNEGDGLID------CMDPD------CCLQSSCQNQPYCRG 814
             C   ++  C  +    G   ID      CM P+      C L  +C + P  +G
Sbjct: 333 DDCSENIDD-CAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKG 387



 Score =  127 bits (318), Expect = 2e-28
 Identities = 88/286 (30%), Positives = 119/286 (41%), Gaps = 46/286 (16%)

Query: 522 CHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQ 581
           CH +  C+S  CH      G  C           NGQY    C C  G+KG +C     +
Sbjct: 373 CHLDDACISNPCH-----KGALCDTNPL------NGQYI---CTCPQGYKGADCTEDVDE 418

Query: 582 CI---DPQCGGRGICIMGS----CACNSGYKGESCEEA--DCIDPGCSNHGVCIHG---- 628
           C       C   G C+       C C  GY G  CE    +C    C N   C+      
Sbjct: 419 CAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGF 478

Query: 629 ECHCSPGWGGSNCEILKTMCPDQ-CSGHGTYLQESG--SCTCDPNWTGPDCSNEI---CS 682
            C C PG+ G +CE+    C    C  +G  + +     C C P +TGP C  +I    S
Sbjct: 479 TCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSS 538

Query: 683 VDCGSHGVCM----GGTCRCEEGWTGPACNQRA--CHPRCAEHGTCKDG----KCECSQG 732
             C +   C+    G  C+C  G+TG  C +    C P    HG C+DG     C C+ G
Sbjct: 539 TPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPG 598

Query: 733 WNGEHCT--IEGC-PGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDV 775
           + G  C+  I+ C    C ++GRC    NG+ C CQPG  G  C++
Sbjct: 599 YMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEI 644



 Score =  112 bits (280), Expect = 5e-24
 Identities = 91/345 (26%), Positives = 125/345 (36%), Gaps = 73/345 (21%)

Query: 519 PRNCHGNGEC-----VSGTCHCFPGFLGPDCSRAA--CPV-LCSGNGQYSKG----RCLC 566
           P  C   G C      +  C+C PGF G  C R    CP   C   G    G     C C
Sbjct: 227 PSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRC 286

Query: 567 FSGWKGTECDVPTTQCI--DPQCGGRGICIMGS----CACNSGYKGESCEEA--DCIDPG 618
              W G  C     +C+     C   G C   +    C C +G+ G+ C E   DC    
Sbjct: 287 PPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFAS 346

Query: 619 CSNHGVCIHG----ECHCSPGWGGSNCEILKTMCPDQCSG---------HGTYLQESGSC 665
           C+    CI       C C  G  G  C +      + C           +G Y+     C
Sbjct: 347 CTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYI-----C 401

Query: 666 TCDPNWTGPDCSNEI--CSV----DCGSHGVCMGGT----CRCEEGWTGPACNQ--RACH 713
           TC   + G DC+ ++  C++     C   G C+       C C +G+ GP C      CH
Sbjct: 402 TCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECH 461

Query: 714 PR-CAEHGTCKDG----KCECSQGWNGEHCTIE--GCPGL-CNSNGRCTLDQNGWHCVCQ 765
              C    TC D      C C  G+ G HC +E   C    C +NG+C    N + C+C 
Sbjct: 462 SDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCP 521

Query: 766 PGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQP 810
           PG+ G  C + ++               DC    C   + C + P
Sbjct: 522 PGFTGPVCQIDID---------------DCSSTPCLNGAKCIDHP 551



 Score = 95.1 bits (235), Expect = 8e-19
 Identities = 84/338 (24%), Positives = 124/338 (36%), Gaps = 60/338 (17%)

Query: 522  CHGNGECVSGT----CHCFPGFLGP-------DCSRAACPVLCSGNGQYSKGRCLCFSGW 570
            C  +G C++      C C  G+ G        +C+   C    + +      RC C  G+
Sbjct: 1120 CQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGY 1179

Query: 571  KGTECDVPTTQCIDPQCGGRGICI----MGSCACNSGYKGESCEE--ADCI-DPGCSNHG 623
            +G  C+    +C +  C   G CI       C+C  G +G  CEE   DC   P C N G
Sbjct: 1180 QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGG 1239

Query: 624  VCIHG----ECHCSPGWGGSNCE-ILKTMCPDQCSGHGT----YLQESGSCTCDPNWTGP 674
             C+       C C PG+ G  CE  +     + CS  G+     L     C C   +TG 
Sbjct: 1240 QCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGR 1299

Query: 675  DCSN--EIC-SVDCGSHGVCM-------GGTCRCEEGWTGPACNQRACHPRCAEHGTC-- 722
             C    ++C  + C + G C        G  CRC  G++G  C       +C +   C  
Sbjct: 1300 HCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVH 1359

Query: 723  --KDGKCECSQGWNGEHCTIEGCPGL-CNSNGRCTLDQNG--WHCVCQPGWRGAGCDV-- 775
                 +C C    + E     GC    C   G C   +    + C C P + G+ C++  
Sbjct: 1360 TASGPRCFCPSPRDCE----SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYT 1415

Query: 776  ------AMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQ 807
                      L     D   DG+ D    + C   +CQ
Sbjct: 1416 APPSTPPATCLSQYCADKARDGVCD----EACNSHACQ 1449



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 77/316 (24%), Positives = 110/316 (34%), Gaps = 94/316 (29%)

Query: 513  ESVVECPR--NCHGNGECVSG----TCHCFPGFLGPDCSRAACPVL---CSGNGQY---- 559
            E++ +C R  +C   G+C+      +C C PGF G  C       L   CS  G      
Sbjct: 1224 ENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQ 1283

Query: 560  --SKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGS-------CACNSGYKGESCE 610
              +   C+C S + G  C+     C    C   G C + S       C C  G+ G  C+
Sbjct: 1284 LTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQ 1343

Query: 611  EA---------------------------DCIDPGCSN----HGVCIHGE-------CHC 632
             +                           DC + GC++    HG   H +       C C
Sbjct: 1344 SSCGQVKCRKGEQCVHTASGPRCFCPSPRDC-ESGCASSPCQHGGSCHPQRQPPYYSCQC 1402

Query: 633  SPGWGGSNCEI------------LKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEI 680
            +P + GS CE+            L   C D+    G   +   S  C   W G DCS  +
Sbjct: 1403 APPFSGSRCELYTAPPSTPPATCLSQYCADKARD-GVCDEACNSHACQ--WDGGDCSLTM 1459

Query: 681  CS--VDCGSHGVCMGG-TCRCEEGWTGPAC---------NQRACH--PRCAEHGTCKDGK 726
             +   +C S   C      +C+E      C         N + C     CA+H   KD  
Sbjct: 1460 ENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADH--FKDNH 1517

Query: 727  CECSQGWNGEHCTIEG 742
            C+  QG N E C  +G
Sbjct: 1518 CD--QGCNSEECGWDG 1531


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  152 bits (384), Expect = 4e-36
 Identities = 103/335 (30%), Positives = 145/335 (43%), Gaps = 61/335 (18%)

Query: 530 SGTCHCFPGFLGPDCSRAACPVLCSGNGQYSK--GRCLCFSGWKGTECD--VPTTQCIDP 585
           +G   C  G++GP+C+RA C   CS      K  G C C  GW+G  CD  +P   C+  
Sbjct: 215 NGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCV-- 272

Query: 586 QCGGRGIC-IMGSCACNSGYKGESCEE--------ADCIDPG-CSNHGVCIHGECHCSPG 635
                GIC     C C + + G+ C++          C++ G CSN G   + +C C  G
Sbjct: 273 ----HGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKY-QCSCPEG 327

Query: 636 WGGSNCEILKTMC-PDQCSGHGTYLQES--GSCTCDPNWTGPDCSNEICSVDCGSHGVCM 692
           + G NCEI +  C  D C   G+  + S    C C P WTGP CS  I   DC  +    
Sbjct: 328 YSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNI--DDCSPNNCSH 385

Query: 693 GGTCR---------CEEGWTGPACNQRA--CHPR-CAEHGTCKD----GKCECSQGWNGE 736
           GGTC+         C   WTG  C   A  C  + C    +CK+      C+C  GW G+
Sbjct: 386 GGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQ 445

Query: 737 HC--TIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEG----- 789
           +C   I  C G C ++  C    NG+ C+C PG+ G  C+  ++   ++   N G     
Sbjct: 446 NCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNE 505

Query: 790 ------------DGLIDCMDPDCCLQSSCQNQPYC 812
                        G +  +D D C  + CQN   C
Sbjct: 506 INRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQC 540



 Score =  132 bits (333), Expect = 4e-30
 Identities = 92/278 (33%), Positives = 112/278 (40%), Gaps = 36/278 (12%)

Query: 561 KGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCEEA--DC 614
           K  C C  G+ GT C      C    C   G CI G     C C+ G++G  CE    DC
Sbjct: 612 KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDC 671

Query: 615 IDPGCSNHGVCIH----GECHCSPGWGGSNCEILKTMCPDQ-CSGHGTYLQESGS--CTC 667
               C N G C        C C  GW G  C    + C +  C+  GT   E  +  C C
Sbjct: 672 SQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMC 731

Query: 668 DPNWTGPDCS---NEICSVD-CGSHGVCMGG----TCRCEEGWTGPACNQRA--CHPR-C 716
              W G  C+   N  C  + C + G C+      TC C+EGW GP C Q    C P  C
Sbjct: 732 PGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPC 791

Query: 717 AEHGTCKDG----KCECSQGWNGEHCTI---EGCPGLCNSNGRCTLDQNGWHCVCQPGWR 769
              GTC DG    +CEC+ G+ G  C I   E     C     C  + NG+ CVC PG  
Sbjct: 792 YNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHS 851

Query: 770 GAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQ 807
           GA C       C        DG     D DC   ++CQ
Sbjct: 852 GAKCQEVSGRPCITMGSVIPDGA--KWDDDC---NTCQ 884



 Score =  122 bits (307), Expect = 4e-27
 Identities = 89/350 (25%), Positives = 131/350 (37%), Gaps = 76/350 (21%)

Query: 533 CHCFPGFLGPDC------------SRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTT 580
           C C PG++G +C            + A+C  L +G       RC+C  G+ G  C+    
Sbjct: 436 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGY------RCICPPGYAGDHCERDID 489

Query: 581 QCIDPQCGGRGICIMG----SCACNSGYKGESCE-EADCIDPG-CSNHGVCIHGE----C 630
           +C    C   G C        C C +G+ G  C+ + D  +P  C N   C +      C
Sbjct: 490 ECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFC 549

Query: 631 HCSPGWGGSNCEILKTMC----------------------------PDQCSGHGTYLQES 662
            C   + G NC  LK  C                             + C  HG    +S
Sbjct: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQS 609

Query: 663 G---SCTCDPNWTGPDCS---NEICSVDCGSHGVCMGGT----CRCEEGWTGPAC--NQR 710
           G   +C C+  +TG  C    N+  S  C + G C+ G     C C +GW G  C  N  
Sbjct: 610 GGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNIN 669

Query: 711 ACHPR-CAEHGTCKD----GKCECSQGWNGEHCTIEGCP---GLCNSNGRCTLDQNGWHC 762
            C    C   GTC+D      C+C  GW G+ C           CN+ G C  + + + C
Sbjct: 670 DCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKC 729

Query: 763 VCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYC 812
           +C  GW G  C++A  + C  +  + G   +   +   C+       P C
Sbjct: 730 MCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779



 Score =  120 bits (301), Expect = 2e-26
 Identities = 87/260 (33%), Positives = 112/260 (43%), Gaps = 48/260 (18%)

Query: 596 GSCACNSGYKGESCEEADCIDPGCS-NHGVC-IHGECHCSPGWGGSNCEILKTMCPDQCS 653
           G+  C  G+ G  C  A C   GCS  HG C + G+C C  GW G  C+      P    
Sbjct: 216 GNKTCMEGWMGPECNRAICRQ-GCSPKHGSCKLPGDCRCQYGWQGLYCD---KCIPHPGC 271

Query: 654 GHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCM-GGTCR----------CEEGW 702
            HG    E   C C+ NW G  C  ++    CG+H  C+ GGTC           C EG+
Sbjct: 272 VHGI-CNEPWQCLCETNWGGQLCDKDLNY--CGTHQPCLNGGTCSNTGPDKYQCSCPEGY 328

Query: 703 TGPACN--QRAC-HPRCAEHGTCKDG----KCECSQGWNGEHCT--IEGC-PGLCNSNGR 752
           +GP C   + AC    C   G+CK+     +CECS GW G  C+  I+ C P  C+  G 
Sbjct: 329 SGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGT 388

Query: 753 CTLDQNGWHCVCQPGWRGAGCDVAMETL----CTDSKDNEG-------DGLIDCMDPDC- 800
           C    NG+ CVC P W G  C +         C ++K  +        D L   M  +C 
Sbjct: 389 CQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCD 448

Query: 801 -----CLQSSCQNQPYCRGL 815
                CL   CQN   CR L
Sbjct: 449 ININDCL-GQCQNDASCRDL 467



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 45/137 (32%), Positives = 66/137 (48%), Gaps = 9/137 (6%)

Query: 661 ESGSCTCDPNWTGPDCSNEICSVDCG-SHGVC-MGGTCRCEEGWTGPACNQRACHPRCAE 718
           ++G+ TC   W GP+C+  IC   C   HG C + G CRC+ GW G  C++   HP C  
Sbjct: 214 QNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCV- 272

Query: 719 HGTCKD-GKCECSQGWNGEHCTIE----GCPGLCNSNGRCT-LDQNGWHCVCQPGWRGAG 772
           HG C +  +C C   W G+ C  +    G    C + G C+    + + C C  G+ G  
Sbjct: 273 HGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPN 332

Query: 773 CDVAMETLCTDSKDNEG 789
           C++A     +D   N G
Sbjct: 333 CEIAEHACLSDPCHNRG 349



 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 54/177 (30%), Positives = 68/177 (38%), Gaps = 39/177 (22%)

Query: 666 TCDPNWTGPDCSNEICSV--DCGSHGVC-MGGTCRCEEGWTGPACNQRACHPRCA-EHGT 721
           TCD  + G  C N+ C    D   H  C   G   C EGW GP CN+  C   C+ +HG+
Sbjct: 186 TCDDYYYGFGC-NKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGS 244

Query: 722 CK-DGKCECSQGWNGEHC----TIEGC-PGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDV 775
           CK  G C C  GW G +C       GC  G+CN           W C+C+  W G  CD 
Sbjct: 245 CKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICN---------EPWQCLCETNWGGQLCDK 295

Query: 776 AMETLCTDSK-------DNEGDGLIDCMDPD------------CCLQSSCQNQPYCR 813
            +    T           N G     C  P+             CL   C N+  C+
Sbjct: 296 DLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK 352



 Score = 63.5 bits (153), Expect = 3e-09
 Identities = 66/270 (24%), Positives = 88/270 (32%), Gaps = 67/270 (24%)

Query: 522 CHGNGECVSG----TCHCFPGFLGPDCSRA----ACPVLCSGNGQY----SKGRCLCFSG 569
           C+  G C        C C  G+ G  C+ A      P  C   G          C+C  G
Sbjct: 714 CNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEG 773

Query: 570 WKGTECDVPTTQCIDPQCGGRGICIMGS----CACNSGYKGESC--EEADCIDPGCSNHG 623
           W+G  C   T  C    C   G C+ G     C C  G+ G  C     +C    C+   
Sbjct: 774 WEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGA 833

Query: 624 VCIHG----ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNE 679
            C+       C C PG  G+ C+        + SG        GS   D      DC+  
Sbjct: 834 TCVDEINGYRCVCPPGHSGAKCQ--------EVSGRPCITM--GSVIPDGAKWDDDCNT- 882

Query: 680 ICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWN----- 734
            C         C+ G   C + W GP    R C            G  EC  G +     
Sbjct: 883 -CQ--------CLNGRIACSKVWCGP----RPC--------LLHKGHSECPSGQSCIPIL 921

Query: 735 GEHCTIEGCPGL--CNSNG------RCTLD 756
            + C +  C G+  C S+       +CT D
Sbjct: 922 DDQCFVHPCTGVGECRSSSLQPVKTKCTSD 951



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 44/171 (25%), Positives = 62/171 (36%), Gaps = 45/171 (26%)

Query: 510 IVIESVVEC-PRNCHGNGECVSG----TCHCFPGFLGPD-------CSRAACPVLCSGNG 557
           I  ++  +C P  C+ +G CV G     C C PGF GPD       C  + C    +   
Sbjct: 778 ICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVD 837

Query: 558 QYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDP 617
           + +  RC+C  G  G +C          +  GR    MGS   +     + C        
Sbjct: 838 EINGYRCVCPPGHSGAKCQ---------EVSGRPCITMGSVIPDGAKWDDDC-------- 880

Query: 618 GCSNHGVCIHGECHCSPGW----------GGSNCEILKTMCP---DQCSGH 655
              N   C++G   CS  W          G S C   ++  P   DQC  H
Sbjct: 881 ---NTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVH 928


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  144 bits (363), Expect = 1e-33
 Identities = 112/359 (31%), Positives = 149/359 (41%), Gaps = 66/359 (18%)

Query: 515 VVECPRN-CHGNGECVSGT----CHCFPGFLGPDCSR-----AACPVLCSGN--GQYSKG 562
           V EC  N C  +  C+       C C PG+ G  C       A+ P L +G    + ++ 
Sbjct: 453 VNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEF 512

Query: 563 RCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCE-EADCIDP 617
           +C C +G+ G  C     +C    C     C+ G    +C C  GY G  CE + D  DP
Sbjct: 513 QCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDP 572

Query: 618 GCSNHGVCIHG----ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGS---CTCDPN 670
              ++G C  G     C C PG+ G +CE     C  Q   HG   Q+  +   C C   
Sbjct: 573 DPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKG 632

Query: 671 WTGPDCSNEICSVDCGSH----GVCM----GGTCRCEEGWTGPACN----QRACHPRCAE 718
            TGP+C  EI   DC S     G C+    G  C CE G+TG  CN    + A +P C  
Sbjct: 633 TTGPNC--EINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNP-CHN 689

Query: 719 HGTCKDG----KCECSQGWNGEHCTIEGCPGLCNSN----GRCTLDQNGWHCVCQPGWRG 770
            GTC+DG     C C +G++   C  E     CNSN    G C    NG+ C C PGW G
Sbjct: 690 GGTCEDGINGFTCRCPEGYHDPTCLSE--VNECNSNPCVHGACRDSLNGYKCDCDPGWSG 747

Query: 771 AGCDV----AMETLCTDS---KDNEGDGLIDCMD----PDC------CLQSSCQNQPYC 812
             CD+         C +    KD     +  C +    P+C      C  + C NQ  C
Sbjct: 748 TNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTC 806



 Score =  140 bits (353), Expect = 2e-32
 Identities = 105/372 (28%), Positives = 149/372 (40%), Gaps = 55/372 (14%)

Query: 514  SVVECPRN-CHGNGECVSGT----CHCFPGFLGPDCSRAACPVL---------CSGNGQY 559
            ++ EC  N C   G C+       C+C   + G  C     P           C  +  Y
Sbjct: 791  NINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDY 850

Query: 560  SKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCEE--AD 613
                C+C +GW+G  C+V   +C+   C     C        C C +GY G +CE    D
Sbjct: 851  ESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDD 910

Query: 614  CIDPGCSNHGVCIHG----ECHCSPGWGGSNCEILKTMC---PDQCSGHGTYLQESGSCT 666
            C    C N G C  G     C C PG+ G+ CE     C   P +   + T   +S +CT
Sbjct: 911  CRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCT 970

Query: 667  CDPNWTGPDCSN---EICSVDCGSHGVCMGG----TCRCEEGWTGPAC----NQRACHPR 715
            C   ++G  C N   +     C + G C+ G    TC C  G+TG  C    N+    P 
Sbjct: 971  CPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQP- 1029

Query: 716  CAEHGTCKDG----KCECSQGWNGEHC--TIEGCPGL-CNSNGRCTLDQNGWHCVCQPGW 768
            C   GTC+DG    +C C QG+ G +C   +  C    C + G+C      + C C  GW
Sbjct: 1030 CLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGW 1089

Query: 769  RGAGCDVAMETLCTDSKDNEG-DGLIDCMDPDCCLQSSCQNQPYCR---GLPDP--QDII 822
             G  CDV     C  +   +G D    C     C+ +   N  +CR   G      +D++
Sbjct: 1090 TGLYCDVP-SVSCEVAAQRQGVDVARLCQHGGLCVDAG--NTHHCRCQAGYTGSYCEDLV 1146

Query: 823  SQSLQSPSQQAA 834
             +   SP Q  A
Sbjct: 1147 DECSPSPCQNGA 1158



 Score =  140 bits (352), Expect = 2e-32
 Identities = 106/362 (29%), Positives = 140/362 (38%), Gaps = 66/362 (18%)

Query: 517 ECPRN-CHGNGECVSGT----CHCFPGFLGPDCSR-----AACPVLCSGNGQYSKG---- 562
           EC  + C  NG C+       C C  GF G  C       A+ P  C    +   G    
Sbjct: 493 ECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTP--CKNGAKCLDGPNTY 550

Query: 563 RCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCEEA--DCID 616
            C+C  G+ GT C+V   +C DP     G C  G    +C C  GY G  CE    +C  
Sbjct: 551 TCVCTEGYTGTHCEVDIDEC-DPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSS 609

Query: 617 PGCSNHGVCIHGE----CHCSPGWGGSNCEILKTMCPDQCSGHGTYLQ--ESGSCTCDPN 670
             C + G C   +    C C  G  G NCEI    C       GT L   +   C C+P 
Sbjct: 610 QPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPG 669

Query: 671 WTGPDCS---NEICSVDCGSHGVCMGG----TCRCEEGWTGPACNQRA--CHPRCAEHGT 721
           +TG  C+   +E     C + G C  G    TCRC EG+  P C      C+     HG 
Sbjct: 670 YTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGA 729

Query: 722 CKDG----KCECSQGWNGEHCTIEGCPGLCNSN-----GRCTLDQNGWHCVCQPGWRGAG 772
           C+D     KC+C  GW+G +C I      C SN     G C    +G+ C C+ G+ G  
Sbjct: 730 CRDSLNGYKCDCDPGWSGTNCDINN--NECESNPCVNGGTCKDMTSGYVCTCREGFSGPN 787

Query: 773 CDVAMETLCTDSKDNEGDGLIDCMDPDC-----------------CLQSSCQNQPYCRGL 815
           C   +    ++   N+G  + D     C                 C  S C+N   CR  
Sbjct: 788 CQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQS 847

Query: 816 PD 817
            D
Sbjct: 848 ED 849



 Score =  132 bits (331), Expect = 6e-30
 Identities = 99/345 (28%), Positives = 130/345 (37%), Gaps = 73/345 (21%)

Query: 520  RNCHGNGECVSGTCHCFPGFLGPDCSRAA--C-PVLCSGNGQYSKGR----CLCFSGWKG 572
            +N HG   C     HC  G+ G +C      C P  C   G  + G     C C  G++G
Sbjct: 885  QNTHGGYRC-----HCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRG 939

Query: 573  TECDVPTTQCIDPQCGGRGICI----MGSCACNSGYKGESCEE--ADCIDPGCSNHGVCI 626
            T C+    +C    C     C       +C C +G+ G  CE    DC +  C N G C+
Sbjct: 940  TFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCV 999

Query: 627  HG----ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQE---SGSCTCDPNWTGPDCSNE 679
             G     C C PG+ GS C+     C  Q   HG   Q+   S  CTC   +TGP+C N 
Sbjct: 1000 DGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNL 1059

Query: 680  ICSVD---CGSHGVCMGG----TCRCEEGWTGPACN------------QRACHPRCAEHG 720
            +   D   C + G C        C C  GWTG  C+            Q     R  +HG
Sbjct: 1060 VHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHG 1119

Query: 721  -TCKDG----KCECSQGWNGEHCT--IEGC-PGLCNSNGRCTLDQNGWHCVCQPGWRGAG 772
              C D      C C  G+ G +C   ++ C P  C +   CT    G+ C C  G+ G  
Sbjct: 1120 GLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVN 1179

Query: 773  CDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPD 817
            C   +                     D CL   CQN   C  LP+
Sbjct: 1180 CSEEI---------------------DECLSHPCQNGGTCLDLPN 1203



 Score =  129 bits (324), Expect = 4e-29
 Identities = 99/343 (28%), Positives = 132/343 (38%), Gaps = 75/343 (21%)

Query: 522 CHGNGEC--VSGT--CHCFPGFLGPDC------------SRAACPVLCS-GNGQYSKGRC 564
           C   G+C   +GT  C C   F+GP C            +   C V+   G   Y+   C
Sbjct: 31  CLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYA---C 87

Query: 565 LCFSGWKGTECDVPTTQ-CIDPQCGGRGICIMGS-----CACNSGYKGESCEEAD-CIDP 617
            C  G+ G  C  P    C+   C   G C + +     C C  G+ G+SC++AD C   
Sbjct: 88  SCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASN 147

Query: 618 GCSNHGVCIHGE----CHCSPGWGGSNCEILKTMC---PDQCSGHGTYLQESGS--CTCD 668
            C+N G C+  E    CHC P + G  C      C   P  C   GT   E GS  C C 
Sbjct: 148 PCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCR 207

Query: 669 PNWTGPDCSNEICSVDCGSHGVCMGGTCR----------CEEGWTGPACNQRACH---PR 715
              TGP+C      V C       GGTCR          C  G+TG  C +         
Sbjct: 208 ATHTGPNCERPY--VPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNN 265

Query: 716 CAEHGTCKDG----KCECSQGWNGEHCT--IEGC---PGLCNSNGRCTLDQNGWHCVCQP 766
           C   G C DG     C C   W G++CT  ++ C   P  C + G C     G++CVC  
Sbjct: 266 CKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVN 325

Query: 767 GWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQ 809
           GW G  C                + + DC    C   ++C ++
Sbjct: 326 GWTGEDC---------------SENIDDCASAACFHGATCHDR 353



 Score =  120 bits (302), Expect = 1e-26
 Identities = 103/363 (28%), Positives = 136/363 (37%), Gaps = 77/363 (21%)

Query: 519 PRNCHGNGEC-----VSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCL-------- 565
           P  C   G C     V+  C C PGF G +C        C GN   + G C+        
Sbjct: 224 PSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDD--CPGNNCKNGGACVDGVNTYNC 281

Query: 566 -CFSGWKGTEC--DVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCEEA--DCID 616
            C   W G  C  DV   Q +   C   G C       +C C +G+ GE C E   DC  
Sbjct: 282 RCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCAS 341

Query: 617 PGCSNHGVCIHGE-----CHCSPGWGGSNCEI----LKTMCPDQCSGHGTYLQESGSCTC 667
             C  HG   H       C C  G  G  C +    +   C +  +     +     CTC
Sbjct: 342 AACF-HGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTC 400

Query: 668 DPNWTGPDCSNEI--CSV---DCGSHGVCMGG----TCRCEEGWTGPAC----NQRACHP 714
              +TGP CS ++  CS+    C   G C+       C+C +G+TGP C    N+   +P
Sbjct: 401 PSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNP 460

Query: 715 RCAEHGTCKDG----KCECSQGWNGEHC---TIEGCPGLCNSNGRCTLDQNGWHCVCQPG 767
            C    TC D     +C C  G+ G HC   T E     C  NGRC    N + C C  G
Sbjct: 461 -CQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTG 519

Query: 768 WRGAGC----DVAMETLCTD-SKDNEGDGLIDCM-----------------DPDCCLQSS 805
           + G  C    D    T C + +K  +G     C+                 DPD C   S
Sbjct: 520 FTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGS 579

Query: 806 CQN 808
           C++
Sbjct: 580 CKD 582



 Score =  117 bits (294), Expect = 1e-25
 Identities = 99/369 (26%), Positives = 129/369 (34%), Gaps = 99/369 (26%)

Query: 519  PRNCHGNGECVSGT----CHCFPGFLGP-------DCSRAACPVLCSGNGQYSKGRCLCF 567
            P  CH  G C  G     C C PGF G        +C+   C    +         C C 
Sbjct: 913  PNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCP 972

Query: 568  SGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCEEA--DCIDPGCSN 621
            +G+ G  C+  T  C +  C   G C+ G    +C C  G+ G  C+    +C    C +
Sbjct: 973  AGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLH 1032

Query: 622  HGVCIHG----ECHCSPGWGGSNCEILKTMCPDQ-CSGHGTYLQESGS--CTCDPNWTG- 673
             G C  G     C C  G+ G NC+ L   C    C   G   Q      C C   WTG 
Sbjct: 1033 GGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGL 1092

Query: 674  ----PDCSNEICS----VD----CGSHGVCM--GGT--CRCEEGWTGPAC---------- 707
                P  S E+ +    VD    C   G+C+  G T  CRC+ G+TG  C          
Sbjct: 1093 YCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPS 1152

Query: 708  ---NQRAC-----------------------------HPRCAEHGTCKD----GKCECSQ 731
               N   C                             HP C   GTC D     KC C +
Sbjct: 1153 PCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHP-CQNGGTCLDLPNTYKCSCPR 1211

Query: 732  GWNGEHCTI--EGC---------PGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETL 780
            G  G HC I  + C            C +NG C     G+ C C PG+ G  C+  +   
Sbjct: 1212 GTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNEC 1271

Query: 781  CTDSKDNEG 789
             ++  D  G
Sbjct: 1272 LSNPCDARG 1280



 Score =  116 bits (291), Expect = 3e-25
 Identities = 101/366 (27%), Positives = 134/366 (36%), Gaps = 77/366 (21%)

Query: 515  VVECPRN-CHGNGECVSGT----CHCFPGFLGPDCSRAA--CPVLCSGNG-----QYSKG 562
            V EC    C   G C  G     C C  G+ GP+C      C      NG      +++ 
Sbjct: 1022 VNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQY 1081

Query: 563  RCLCFSGWKGTECDVPTTQC----------IDPQCGGRGICIMGS----CACNSGYKGES 608
            RC C SGW G  CDVP+  C          +   C   G+C+       C C +GY G  
Sbjct: 1082 RCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSY 1141

Query: 609  CEEA--DCIDPGCSNHGVCIHG----ECHCSPGWGGSNC-EILKTMCPDQCSGHGTYLQ- 660
            CE+   +C    C N   C        C C  G+ G NC E +       C   GT L  
Sbjct: 1142 CEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDL 1201

Query: 661  -ESGSCTCDPNWTGPDCSNEI--C---------SVDCGSHGVCM----GGTCRCEEGWTG 704
              +  C+C     G  C   +  C         S  C ++G C+    G +C C  G+ G
Sbjct: 1202 PNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVG 1261

Query: 705  PAC----NQRACHPRCAEHGT------CKDGKCECSQGWNGEHC--TIEGCPGL-CNSNG 751
              C    N+   +P C   GT        D  CEC  G  G  C   I GC G  C + G
Sbjct: 1262 ERCEGDVNECLSNP-CDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGG 1320

Query: 752  RCTLDQN---GWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQN 808
             C +  N   G+ C C  G+ GA C+           D    G + C++   C+      
Sbjct: 1321 TCAVASNTARGFICKCPAGFEGATCE----------NDARTCGSLRCLNGGTCISGPRSP 1370

Query: 809  QPYCRG 814
               C G
Sbjct: 1371 TCLCLG 1376



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 76/321 (23%), Positives = 102/321 (31%), Gaps = 89/321 (27%)

Query: 515  VVEC---PRNCHGNGECVSGT----CHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCL-- 565
            V EC   P +  G   CV       C C  G  G  C        C G    + G C   
Sbjct: 1268 VNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVING--CKGKPCKNGGTCAVA 1325

Query: 566  ----------CFSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCE- 610
                      C +G++G  C+     C   +C   G CI G    +C C   + G  C+ 
Sbjct: 1326 SNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQF 1385

Query: 611  --EADCIDPG-CSNHGVC------IHGECHCSPGWGGSNCEILKTMCPDQCSGHGT---- 657
               + C+    C N G C          C C   + G  C IL     D   G G     
Sbjct: 1386 PASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHIL-----DYSFGGGAGRDI 1440

Query: 658  ---YLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHP 714
                ++E+    C+      D  N++CS+ C +H            GW G  C+     P
Sbjct: 1441 PPPLIEEA----CELPECQEDAGNKVCSLQCNNHAC----------GWDGGDCSLNFNDP 1486

Query: 715  --RCAEHGTC----KDGKCECSQGWNGEHCTIEG-----CPGLCN-----------SNGR 752
               C +   C     DG C+     N   C  +G       G CN           S+G 
Sbjct: 1487 WKNCTQSLQCWKYFSDGHCDSQ--CNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGH 1544

Query: 753  CTLDQNGWHCVCQPGWRGAGC 773
            C    N   C     W G  C
Sbjct: 1545 CDQGCNSAEC----EWDGLDC 1561



 Score = 36.6 bits (83), Expect = 0.34
 Identities = 32/123 (26%), Positives = 49/123 (39%), Gaps = 10/123 (8%)

Query: 169  ENEQPASNQGQSTLQPLPPSHKQHSAQHHPSITSLNRNSLTNRRNQS---PAPPAALPAE 225
            +N QPA+ Q Q +LQP PP  + H      +   L R+ L+   +Q+   P  P++L   
Sbjct: 2395 QNLQPANIQQQQSLQPPPPPPQPHLGVSSAASGHLGRSFLSGEPSQADVQPLGPSSLAVH 2454

Query: 226  LQTTPESVQLQDSWVLGSNVPLESRHFL-------FKTGTGTTPLFSTATPGYTMASGSV 278
                 ES  L  S       P+ +  FL       + +    TP      P +   + S 
Sbjct: 2455 TILPQESPALPTSLPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSP 2514

Query: 279  YSP 281
             SP
Sbjct: 2515 ESP 2517


>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
          Length = 1590

 Score =  142 bits (359), Expect = 3e-33
 Identities = 86/292 (29%), Positives = 114/292 (39%), Gaps = 42/292 (14%)

Query: 518  CPRNCHGNGECVS-GTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGR-CLCFSGWKGTEC 575
            C   C  + ECV+   C C PG++G +C  A C   C  +G+  K   C C  G  G  C
Sbjct: 1298 CKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATC 1357

Query: 576  DVPTTQCIDPQCGGRGICIMGS-CACNSGYKGESCEEADCIDPGCSNHGVCIHGE-CHCS 633
            D    +  +P C   G C+ G+ C C  G+ G  CE   C +  C N G C+  + C C 
Sbjct: 1358 D---EEHCNPPCQHGGTCLAGNLCTCPYGFVGPRCETMVC-NRHCENGGQCLTPDICQCK 1413

Query: 634  PGWGGSNCEIL----------------KTMCPDQCSG-------------HGTYLQESGS 664
            PGW G  C                     +CP+   G             +G +   +  
Sbjct: 1414 PGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQNAFCHPPCKNGGHCMRNNV 1473

Query: 665  CTCDPNWTGPDCSNEICSVDCGSHGVCMG-GTCRCEEGWTGPACNQRACHPRCAEHGTC- 722
            C C   +TG      IC   C + G C+G  TC C  GW+G  CN   C  +C   G C 
Sbjct: 1474 CVCREGYTGRRFQKSICDPTCMNGGKCVGPSTCSCPSGWSGKRCNTPICLQKCKNGGECI 1533

Query: 723  KDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCD 774
                C C   W G  C I  C   C   GRC        C C+  + G  C+
Sbjct: 1534 APSICHCPSSWEGVRCQIPICNPKCLYGGRCIFPN---VCSCRTEYSGVKCE 1582



 Score =  137 bits (346), Expect = 1e-31
 Identities = 105/368 (28%), Positives = 139/368 (37%), Gaps = 87/368 (23%)

Query: 497  NDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGT----------CHCFPGFLGPDCSR 546
            ND  +AE      + IE  V+   +C   G CVS            C C PGF G     
Sbjct: 1163 NDDCDAE----TRVTIEVTVKSC-DCLNGGSCVSDRNFSPGSGVYLCVCLPGFHG----- 1212

Query: 547  AACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQ-------------------- 586
            + C V  SG      G     SG+    CD P    ++ Q                    
Sbjct: 1213 SLCEVDISGCQSNPCGLGSYISGFHSYSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVN 1272

Query: 587  -----------------------------CGGRGICIMGS-CACNSGYKGESCEEADCID 616
                                         CG    C+  + C C  GY G +C+ A C D
Sbjct: 1273 KEEDDKNAQGRKRHVKPTSGNAFTICKYPCGKSRECVAPNICKCKPGYIGSNCQTALC-D 1331

Query: 617  PGCSNHGVCIHGE-CHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPD 675
            P C NHG CI    C C PG GG+ C+  +  C   C   GT L     CTC   + GP 
Sbjct: 1332 PDCKNHGKCIKPNICQCLPGHGGATCD--EEHCNPPCQHGGTCL-AGNLCTCPYGFVGPR 1388

Query: 676  CSNEICSVDCGSHGVCM-GGTCRCEEGWTGPACNQRACHPRCAEHGTC-KDGKCECSQGW 733
            C   +C+  C + G C+    C+C+ GW GP C+   C P C   G+C K   C C  G+
Sbjct: 1389 CETMVCNRHCENGGQCLTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGF 1448

Query: 734  NGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLI 793
             GEHC    C   C + G C  +     CVC+ G+ G       +++C  +  N G    
Sbjct: 1449 FGEHCQNAFCHPPCKNGGHCMRNN---VCVCREGYTGRR---FQKSICDPTCMNGG---- 1498

Query: 794  DCMDPDCC 801
             C+ P  C
Sbjct: 1499 KCVGPSTC 1506



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 6/97 (6%)

Query: 518  CPRNCHGNGECVS-GTCHCFPGFLGPDCSRAACPVLCSGNGQ-YSKGRCLCFSGWKGTEC 575
            C   C   G+CV   TC C  G+ G  C+   C   C   G+  +   C C S W+G  C
Sbjct: 1490 CDPTCMNGGKCVGPSTCSCPSGWSGKRCNTPICLQKCKNGGECIAPSICHCPSSWEGVRC 1549

Query: 576  DVPTTQCIDPQCGGRGICIMGS-CACNSGYKGESCEE 611
             +P     +P+C   G CI  + C+C + Y G  CE+
Sbjct: 1550 QIPIC---NPKCLYGGRCIFPNVCSCRTEYSGVKCEK 1583



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 33/104 (31%), Positives = 45/104 (43%), Gaps = 13/104 (12%)

Query: 498 DGK-NAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGN 556
           +GK N E+   +   I SV++CP  C GNG+C+   C C P F   DCS           
Sbjct: 869 EGKYNTEEYGTSIEDILSVLKCPNLCSGNGQCMEWGCACSPSFSSYDCS----------- 917

Query: 557 GQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCAC 600
             Y K   +   G  G  CDV    C+  +  G+G   + S  C
Sbjct: 918 DSYDKAPEITELGNAGF-CDVQKYNCMMVRVFGKGFKELPSIKC 960



 Score = 33.9 bits (76), Expect = 2.2
 Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 7/61 (11%)

Query: 636 WGGSNCEILKTM-CPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICS----VDCGSHGV 690
           +G S  +IL  + CP+ CSG+G  ++    C C P+++  DCS+         + G+ G 
Sbjct: 877 YGTSIEDILSVLKCPNLCSGNGQCME--WGCACSPSFSSYDCSDSYDKAPEITELGNAGF 934

Query: 691 C 691
           C
Sbjct: 935 C 935



 Score = 33.1 bits (74), Expect = 3.8
 Identities = 12/31 (38%), Positives = 15/31 (48%), Gaps = 4/31 (12%)

Query: 743 CPGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 773
           CP LC+ NG+C      W C C P +    C
Sbjct: 890 CPNLCSGNGQCM----EWGCACSPSFSSYDC 916


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  142 bits (357), Expect = 6e-33
 Identities = 112/365 (30%), Positives = 142/365 (38%), Gaps = 78/365 (21%)

Query: 522  CHGNGECVSGT----CHCFPGFLGPDCSRAA--CPVLCSGNGQYSKGR-----CLCFSGW 570
            C   G C S      C C PG  G  C   +   P  C   G+          C C  GW
Sbjct: 743  CRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGW 802

Query: 571  KGTECDVPTTQCIDPQ-CGGRGIC--IMGS--CACNSGYKGESCEEA--DCIDPGCSNHG 623
            +G  C     +C  P  CG  GIC  + GS  C C+ GY G SC++   DC    C N G
Sbjct: 803  QGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGG 862

Query: 624  VCIHG----ECHCSPGWGGSNC-----EILKTMC-PDQCSGHGTYLQESGSCTCDPNWTG 673
             C  G     C C PG+ G  C     E L   C P  C+ H      S +CTC P + G
Sbjct: 863  SCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVA----SFTCTCPPGYGG 918

Query: 674  PDCSNEI--CSVD-CGSHGVCMGG----TCRCEEGWTGPACNQRA--CHPR-CAEHGTCK 723
              C  ++  CS   C + G C+ G    +C C  G+TG  C   A  C  R C   G C 
Sbjct: 919  FHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCS 978

Query: 724  DG----KCECSQGWNGEHCT--IEGCPGL-CNSNGRCTLDQNGWHCVCQPGWRGAGCD-- 774
                  +C C + + G  C   ++ C    C + GRC   Q G +C+C PGW G  CD  
Sbjct: 979  AAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCV--QTGAYCLCPPGWSGRLCDIR 1036

Query: 775  ------------VAMETLCT---DSKDNEGDGLIDC----------MDPDCCLQSSCQNQ 809
                        V +E LC       D +      C           + D CL   CQ+ 
Sbjct: 1037 SLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHG 1096

Query: 810  PYCRG 814
              CRG
Sbjct: 1097 GTCRG 1101



 Score =  133 bits (335), Expect = 2e-30
 Identities = 111/361 (30%), Positives = 147/361 (40%), Gaps = 71/361 (19%)

Query: 522 CHGNGEC----VSGT----CHCFPGFLGPDCSRAACPVL---CSGNGQYSKG-----RCL 565
           C G G C    V+GT    C C  GF GPDCS    P L   C+   + S G      C 
Sbjct: 87  CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS-LPDPCLSSPCAHGARCSVGPDGRFLCS 145

Query: 566 CFSGWKGTECDVPTTQC-IDPQCGGRGICI--MGS--CACNSGYKGESCEE--ADCIDPG 618
           C  G++G  C     +C +   C   G C+   GS  C C +GY G  CE     C    
Sbjct: 146 CPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSP 205

Query: 619 CSNHGVC-----IHGECHCSPGWGGSNCEILKTMCP-DQCSGHGTYLQ--ESGSCTCDPN 670
           C N G C     +  +C C PG+ G NCE+    CP  +C   GT +    + +C C P 
Sbjct: 206 CRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPE 265

Query: 671 WTGPDCSNEI--CSVD---CGSHGVCM----GGTCRCEEGWTGPACNQRA--CHPRCAEH 719
           WTG  C+ ++  C +    C + G C     G +C C  GWTG +C+Q    C      H
Sbjct: 266 WTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFH 325

Query: 720 G-TCKDG----KCECSQGWNGEHCTIEGC--PGLCNSNGRC-TLDQNGWH-CVCQPGWRG 770
           G TC D      C C  G  G  C ++       C+ +  C T   NG   C C PG+ G
Sbjct: 326 GATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTG 385

Query: 771 AGCDVAMETLCTDSK---------DNEGDGLIDC----MDPDC------CLQSSCQNQPY 811
             CD  ++     +          + +G  L  C      P C      CL   C+NQ  
Sbjct: 386 GACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQAT 445

Query: 812 C 812
           C
Sbjct: 446 C 446



 Score =  133 bits (335), Expect = 2e-30
 Identities = 105/345 (30%), Positives = 132/345 (38%), Gaps = 63/345 (18%)

Query: 509 TIVIESVVEC-PRNCHGNGECVSG----TCHCFPGFLGPDCSRAACPVL---CSGNGQ-- 558
           T+   +V +C P  CH +G CV G    +C C PG+ G  C           C   G+  
Sbjct: 540 TLCDRNVDDCSPDPCH-HGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCL 598

Query: 559 --YSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESC--E 610
               K  C C SG  G  C+V    C    C   G+C  G     C C  G+ G  C  E
Sbjct: 599 DLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTF-GVCRDGINRYDCVCQPGFTGPLCNVE 657

Query: 611 EADCIDPGCSNHGVCIHGE----CHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGS-- 664
             +C    C   G C+ GE    C C PG     C      C  +   HG      G   
Sbjct: 658 INECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFR 717

Query: 665 CTCDPNWTGPDCSNEIC-----SVDCGSHGVC----MGGTCRCEEGWTGPACNQRA-CHP 714
           C C+P W+GP CS  +      S  C + G C    MG  C C  G  G  C   + C P
Sbjct: 718 CVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTP 777

Query: 715 RCAEH-GTCKDGK-----CECSQGWNGEHC--TIEGC--PGLCNSNGRCTLDQNGWHCVC 764
              EH G C+        C C QGW G  C   ++ C  P  C  +G CT     + C C
Sbjct: 778 NPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTC 837

Query: 765 QPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQ-SSCQN 808
             G+ G  CD                 + DC DP+ CL   SCQ+
Sbjct: 838 HGGYTGPSCD---------------QDINDC-DPNPCLNGGSCQD 866



 Score =  132 bits (331), Expect = 6e-30
 Identities = 99/300 (33%), Positives = 120/300 (40%), Gaps = 43/300 (14%)

Query: 517 ECPRN-CHGNGECVSGT----CHCFPGFLGPDCSRAACPVL---CSGNGQYSKG---RCL 565
           EC  + C   G CV G     C C PG L P C   + P     CS    Y      RC+
Sbjct: 660 ECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCV 719

Query: 566 CFSGWKGTECDVPTTQ--CIDPQCGGRGICI---MG-SCACNSGYKGESCEE-ADCIDPG 618
           C  GW G  C     +  C    C   G C    MG  C C  G +G  CE  + C    
Sbjct: 720 CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779

Query: 619 CSNHGVCIHGE-----CHCSPGWGGSNCEILKTMC--PDQCSGHG--TYLQESGSCTCDP 669
           C + G C         C C  GW G  C+     C  P  C  HG  T L  S SCTC  
Sbjct: 780 CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHG 839

Query: 670 NWTGPDCSNEICSVD---CGSHGVCMGG----TCRCEEGWTGPACNQRA--CHPRCAEHG 720
            +TGP C  +I   D   C + G C  G    +C C  G+ GP C +    C       G
Sbjct: 840 GYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG 899

Query: 721 TCKDG----KCECSQGWNGEHCT--IEGC-PGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 773
           TC D      C C  G+ G HC   +  C P  C + G C    N + C+C+PG+ GA C
Sbjct: 900 TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHC 959



 Score =  129 bits (323), Expect = 5e-29
 Identities = 88/286 (30%), Positives = 121/286 (42%), Gaps = 41/286 (14%)

Query: 522 CHGNGECV----SGTCHCFPGFLGP-------DCSRAACPVLCSGNGQYSKGRCLCFSGW 570
           C   G CV    S  C C  G+ GP       +C    C    +   +  +  C+C +G+
Sbjct: 402 CEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGF 461

Query: 571 KGTECDVPTTQCIDPQCGGRGIC---IMG-SCACNSGYKGESC--EEADCIDPGCSNHGV 624
            GT C+V   +C    C   G+C   + G SC C SG+ G +C  +  +C    C N   
Sbjct: 462 TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAK 521

Query: 625 CIHG----ECHCSPGWGGSNCEILKTMC-PDQCSGHGTYLQ--ESGSCTCDPNWTGPDCS 677
           C+      EC C+ G+ G+ C+     C PD C  HG  +    S SC C P +TG  C 
Sbjct: 522 CVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH-HGRCVDGIASFSCACAPGYTGTRCE 580

Query: 678 NEI--C-SVDCGSHGVCMG----GTCRCEEGWTGPAC--NQRACHPRCAEHGTCKDG--- 725
           +++  C S  C   G C+       CRC  G TG  C  N   C       G C+DG   
Sbjct: 581 SQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINR 640

Query: 726 -KCECSQGWNGEHCTI---EGCPGLCNSNGRCTLDQNGWHCVCQPG 767
             C C  G+ G  C +   E     C   G C   +NG+ C+C PG
Sbjct: 641 YDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPG 686



 Score =  127 bits (320), Expect = 1e-28
 Identities = 90/291 (30%), Positives = 120/291 (41%), Gaps = 51/291 (17%)

Query: 537 PGFLGPDCSRAACPVLCSGNGQYSK-----GRCLCFSGWKGTECDVPTTQCIDPQCGGRG 591
           PG   P C   +    C+  G+ ++       CLC  GW G  C +    C    C GRG
Sbjct: 36  PGAAAPPCLDGSP---CANGGRCTQLPSREAACLCPPGWVGERCQLEDP-CHSGPCAGRG 91

Query: 592 IC----IMG----SCACNSGYKGESCEEAD-CIDPGCSNHGVCIHGE-----CHCSPGWG 637
           +C    + G    SC C  G++G  C   D C+   C++   C  G      C C PG+ 
Sbjct: 92  VCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ 151

Query: 638 GSNC--EILKTMCPDQCSGHGTYLQESGS--CTCDPNWTGPDCSNEICSVDCGSHGVCMG 693
           G +C  ++ +    + C   GT L   GS  C C   +TGP C N   +V C       G
Sbjct: 152 GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENP--AVPCAPSPCRNG 209

Query: 694 GTCR----------CEEGWTGPAC--NQRACHP-RCAEHGTCKDG----KCECSQGWNGE 736
           GTCR          C  G+ G  C  N   C   RC   GTC DG     C+C   W G+
Sbjct: 210 GTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQ 269

Query: 737 HCT--IEGC---PGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCT 782
            CT  ++ C   P  C++ G C     G  CVC  GW G  C   ++   T
Sbjct: 270 FCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCAT 320



 Score =  113 bits (282), Expect = 3e-24
 Identities = 92/355 (25%), Positives = 128/355 (36%), Gaps = 52/355 (14%)

Query: 514 SVVECP-RNCHGNGECVSGT----CHCFPGFLGPDCSRAACPVLCSGNGQYSKGRC---- 564
           +V +CP   C   G CV G     C C P + G  C+          N  ++ G C    
Sbjct: 236 NVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTL 295

Query: 565 -----LCFSGWKGTECDVPTTQCIDPQCGGRGIC----IMGSCACNSGYKGESCEEAD-C 614
                +C +GW G  C      C    C     C        CAC  G  G  C   D C
Sbjct: 296 GGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDAC 355

Query: 615 IDPGCSNHGVC----IHGE--CHCSPGWGGSNCEILKTMCP---DQCSGHGTYLQESGS- 664
           +   C    +C    ++G   C C PG+ G  C+     C    + C   G  +   GS 
Sbjct: 356 VSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSF 415

Query: 665 -CTCDPNWTGPDCS---NEICSVDCGSHGVCMGG----TCRCEEGWTGPACN---QRACH 713
            C C   +TGP C    NE  S  C +   C+      TC C  G+TG  C         
Sbjct: 416 LCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQS 475

Query: 714 PRCAEHGTCKDG----KCECSQGWNGEHCT--IEGCPGL-CNSNGRCTLDQNGWHCVCQP 766
             C   G CKD      C C  G++G  C   ++ C    C +  +C    +G+ C C  
Sbjct: 476 SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAE 535

Query: 767 GWRGAGCDVAMETL----CTDSKDNEGDGLIDCMDPDCCLQSSCQNQ-PYCRGLP 816
           G+ G  CD  ++      C   +  +G     C        + C++Q   CR  P
Sbjct: 536 GFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQP 590



 Score =  109 bits (272), Expect = 4e-23
 Identities = 97/348 (27%), Positives = 128/348 (36%), Gaps = 72/348 (20%)

Query: 519 PRNCHGNGEC-----VSGTCHCFPGFLGPDCSRAA--CPV-LCSGNGQYSKG----RCLC 566
           P  C   G C     ++  C C PGF G +C      CP   C   G    G     C C
Sbjct: 203 PSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQC 262

Query: 567 FSGWKGTECDVPTTQC-IDPQ-CGGRGICI--MG--SCACNSGYKGESCEEA--DCIDPG 618
              W G  C     +C + P  C   G C   +G  SC C +G+ GESC +   DC    
Sbjct: 263 PPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAV 322

Query: 619 CSNHGVCIHGE-----CHCSPGWGGSNCEI----LKTMCPDQCSGHGTYLQESGSCTCDP 669
           C  HG   H       C C  G  G  C +    +   C +        +     CTC P
Sbjct: 323 CF-HGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPP 381

Query: 670 NWTGPDCSNEI--CSV---DCGSHGVCMGG----TCRCEEGWTGPAC----NQRACHPRC 716
            +TG  C  ++  CS+    C   G C+       C+C  G+TGP C    N+    P C
Sbjct: 382 GFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGP-C 440

Query: 717 AEHGTCKDG----KCECSQGWNGEHC--TIEGCPGL-CNSNGRCTLDQNGWHCVCQPGWR 769
               TC D      C C  G+ G +C   I+ C    C + G C    NG+ C C  G+ 
Sbjct: 441 RNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFS 500

Query: 770 GAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPD 817
           G+ C                      +D D C  + C+N   C   PD
Sbjct: 501 GSTCQ---------------------LDVDECASTPCRNGAKCVDQPD 527



 Score = 99.4 bits (246), Expect = 4e-20
 Identities = 95/345 (27%), Positives = 118/345 (34%), Gaps = 92/345 (26%)

Query: 520  RNCHGNGECVSG----TCHCFPGFLGPDC-------SRAACPV--LCSGNGQYSKGRCLC 566
            R C   G C +      C C   F GP C       SR  C     C   G Y    CLC
Sbjct: 969  RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY----CLC 1024

Query: 567  FSGWKGTECDVPTTQC----------IDPQCGGRGICIMGS----CACNSGYKGESCEEA 612
              GW G  CD+ +  C          ++  C   G C+       C C  G  G  CE+ 
Sbjct: 1025 PPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQE 1084

Query: 613  --DCIDPGCSNHGVC---IHGE-CHCSPGWGGSNCEILKTMCPDQCSGHG---TYLQESG 663
               C+   C + G C   + G  C C PG+ G NCE     C  Q   HG     L    
Sbjct: 1085 VDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARY 1144

Query: 664  SCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCK 723
             C+C P   G  C  EI   DCG                 GP  +     PRC  +GTC 
Sbjct: 1145 LCSCPPGTLGVLC--EINEDDCG----------------PGPPLDS---GPRCLHNGTCV 1183

Query: 724  D----GKCECSQGWNGEHC--TIEGC-PGLCNS--NGRCTLDQ-NGWHCVCQPGWRGAGC 773
            D     +C C  G+ G  C   I  C  G C++     C  D   G+ C+C  G+ G  C
Sbjct: 1184 DLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRC 1243

Query: 774  DVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDP 818
               +                       C    CQ+   CR  P P
Sbjct: 1244 QTVLSP---------------------CESQPCQHGGQCRPSPGP 1267



 Score = 95.1 bits (235), Expect = 8e-19
 Identities = 95/376 (25%), Positives = 131/376 (34%), Gaps = 91/376 (24%)

Query: 513  ESVVECPRN-CHGNGECVSGT----CHCFPGFLGPDC--SRAAC---PVLCSGNGQYSKG 562
            + V EC    C   G C+       C C PG LG  C  +   C   P L SG      G
Sbjct: 1121 DDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNG 1180

Query: 563  ---------RCLCFSGWKGTECDVPTTQCIDPQCGGRGI--CIMGS-----CACNSGYKG 606
                     RC C  G+ G  C+    +C    C       C+        C C++G+ G
Sbjct: 1181 TCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSG 1240

Query: 607  ESCEE--ADCIDPGCSNHGVC---------IHGECHCSPGWGGSNCEILKTMCPDQCSGH 655
              C+   + C    C + G C         +   CHC+  + G  CE +   C +     
Sbjct: 1241 PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPV 1300

Query: 656  GTYLQESGS---CTCDPNWTGPDCSNEICSVDCGSHGVCM------GGTCR--------- 697
            G   Q++     C C P  +GP C +   S    S+  C       GG+CR         
Sbjct: 1301 GVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFR 1360

Query: 698  --CEEGWTGPACNQRACHPRCAEHGTCKDGKC-----------ECSQ---GWNGEHCTI- 740
              C +GWTGP C   A  P  +E   C    C           EC+    GW+G  C++ 
Sbjct: 1361 CACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLS 1420

Query: 741  -----EGCPGL----CNSNGRCTLDQNGWHCV-----CQPGWRGAGCDVAMETLCTDSKD 786
                   C  L      +N RC    +   C+     C  G R   C+   E  C    D
Sbjct: 1421 VGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCA---D 1477

Query: 787  NEGDGLID--CMDPDC 800
            +  DG  D  C   +C
Sbjct: 1478 HFADGRCDQGCNTEEC 1493



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 49/200 (24%), Positives = 67/200 (33%), Gaps = 60/200 (30%)

Query: 533  CHCFPGFLGPDC-------------SRAACPVLCSGNGQYSK----GRCLCFSGWKGTEC 575
            C C PG  GP C             S AA P L  G+ + +      RC C  GW G  C
Sbjct: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRC 1372

Query: 576  DVPTT--------------------------QCIDPQCGGRGICIMGSCACNSGYKGESC 609
            + P                            +C  P CG  G    G C+ + G     C
Sbjct: 1373 EAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDG----GDCSLSVGDPWRQC 1428

Query: 610  EEADC--------IDPGCSNHGVCIHGECHCSPGWGGSNCE-ILKTMCPDQCSGHGTYLQ 660
            E   C         DP CS+   C++    C  G     C  + +  C D  +       
Sbjct: 1429 EALQCWRLFNNSRCDPACSSPA-CLYDNFDCHAGGRERTCNPVYEKYCADHFADGRC--- 1484

Query: 661  ESGSCTCDPNWTGPDCSNEI 680
            + G  T +  W G DC++E+
Sbjct: 1485 DQGCNTEECGWDGLDCASEV 1504



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 34/119 (28%), Positives = 42/119 (35%), Gaps = 33/119 (27%)

Query: 716 CAEHGTC-----KDGKCECSQGWNGEHCTIEG-C-PGLCNSNGRC----TLDQNGWHCVC 764
           CA  G C     ++  C C  GW GE C +E  C  G C   G C          + C C
Sbjct: 49  CANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRC 108

Query: 765 QPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIIS 823
             G+RG                       DC  PD CL S C +   C   PD + + S
Sbjct: 109 PRGFRGP----------------------DCSLPDPCLSSPCAHGARCSVGPDGRFLCS 145


>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
          Length = 1140

 Score =  140 bits (353), Expect = 2e-32
 Identities = 108/355 (30%), Positives = 138/355 (38%), Gaps = 100/355 (28%)

Query: 517 ECPRNCHGNGEC--VSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           EC   CH  G C   +G CHC PG+ G  C +  CPV                 G  G  
Sbjct: 280 EC--QCHNGGTCDAATGQCHCSPGYTGERC-QDECPV-----------------GTYGVL 319

Query: 575 CDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADC--------IDPGCSNHGVCI 626
           C   T QC++   GG+   + G+C C +G+ GE CE   C         D  C  H    
Sbjct: 320 C-AETCQCVN---GGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENT 375

Query: 627 H------GECHCSPGWGGSNC----------EILKTMCPDQCSGHGTYLQESGSCTCDPN 670
           H      GEC C PGW G  C          E  + +C   C         +G CTC P 
Sbjct: 376 HSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQIC--SCQNGADCDSVTGKCTCAPG 433

Query: 671 WTGPDCSNEI--------CSVDCG--SHGVC--MGGTCRCEEGWTGPACNQR-------- 710
           + G DCS           CS  CG  +  VC  + G+C C+ GW G  C+ R        
Sbjct: 434 FKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGF 493

Query: 711 ACH--PRCAEHGTCK--DGKCECSQGWNGEHCTI---EGCPGLCNSNGRCTLDQ------ 757
            C+   +C   G C   DG C C+ GW GE C +   +G  GL N   RC          
Sbjct: 494 GCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGL-NCAERCDCSHADGCHP 552

Query: 758 NGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYC 812
              HC C PGW G  CD    ++C + +            P+C L   C+N   C
Sbjct: 553 TTGHCRCLPGWSGVHCD----SVCAEGR----------WGPNCSLPCYCKNGASC 593



 Score =  134 bits (338), Expect = 9e-31
 Identities = 107/385 (27%), Positives = 139/385 (36%), Gaps = 102/385 (26%)

Query: 521 NCHGNGEC--------VSGTCHCFPGFLGPDCS------------RAACPVLCSGNGQYS 560
           +CH   +C        V+G C C PG+ G  C                CP    G   + 
Sbjct: 190 DCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHV 249

Query: 561 KGRCLCFSGWKGTECDVPTTQ-------CIDPQCGGRGIC--IMGSCACNSGYKGESCEE 611
            G C C SGW GT C  P  +         + QC   G C    G C C+ GY GE C++
Sbjct: 250 TGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQD 309

Query: 612 ADCIDP---------GCSNHGVCIH--GECHCSPGWGGSNCE-------ILKTMCPDQCS 653
              +            C N G C H  G C C  G+ G  CE       +    C  +C 
Sbjct: 310 ECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCP 369

Query: 654 GHGTYLQE----SGSCTCDPNWTGPDCS------------NEICSVDCGSHGVCMGGTCR 697
            H          SG C C P W+G  C+             +ICS   G+    + G C 
Sbjct: 370 CHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCT 429

Query: 698 CEEGWTGPACNQRA--------CHPRCA--EHGTCK--DGKCECSQGWNGEHCTIEGCPG 745
           C  G+ G  C+           C  RC       C   DG C C  GW+G  C+I  CP 
Sbjct: 430 CAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIR-CPS 488

Query: 746 -----------LCNSNGRC-TLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLI 793
                       C + G C TLD     C C PGWRG  C++  +         +G   +
Sbjct: 489 GTWGFGCNLTCQCLNGGACNTLDGT---CTCAPGWRGEKCELPCQ---------DGTYGL 536

Query: 794 DCMDP-DCCLQSSCQ-NQPYCRGLP 816
           +C +  DC     C     +CR LP
Sbjct: 537 NCAERCDCSHADGCHPTTGHCRCLP 561



 Score =  129 bits (325), Expect = 3e-29
 Identities = 100/340 (29%), Positives = 129/340 (37%), Gaps = 87/340 (25%)

Query: 515 VVECPRNCHGNGECVS-GTCHCFPGFLGPDCSRAA--------CPVLCS-GNGQYSK--- 561
           V  C   C  +G C++  TC C PG+ G +CS A         C   C   NG       
Sbjct: 106 VPHCADKCV-HGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPIT 164

Query: 562 GRCLCFSGWKGTECDVPTTQ------CIDP-QCGGRGIC--IMGSCACNSGYKGESCEEA 612
           G C C +G++G  C+    Q      C    QC     C  + G C C  GY G  CE  
Sbjct: 165 GACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCE-- 222

Query: 613 DCIDPG-----------CSNHGVCIH--GECHCSPGWGGSNCEILKTMCPD--------- 650
           D   PG           C N GVC H  GEC C  GW G+ C      CP+         
Sbjct: 223 DLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVC---GQPCPEGRFGKNCSQ 279

Query: 651 --QCSGHGTYLQESGSCTCDPNWTGPDCSNE--------IC--SVDCGSHGVC--MGGTC 696
             QC   GT    +G C C P +TG  C +E        +C  +  C + G C  + G C
Sbjct: 280 ECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGAC 339

Query: 697 RCEEGWTGPACNQRACHP-----RCAEHGTC----------KDGKCECSQGWNGEHCTI- 740
            CE G+ G  C  R C       +C +   C            G+C C  GW+G +C   
Sbjct: 340 LCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNET 399

Query: 741 -------EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 773
                  E C  +C+       D     C C PG++G  C
Sbjct: 400 CSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDC 439



 Score =  129 bits (323), Expect = 5e-29
 Identities = 98/339 (28%), Positives = 126/339 (37%), Gaps = 92/339 (27%)

Query: 522 CHGNGEC--VSGTCHCFPGFLGPDCSRAA--------CPVLCS---GNGQY-SKGRCLCF 567
           C   G C  + GTC C PG+ G  C            C   C     +G + + G C C 
Sbjct: 501 CLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCL 560

Query: 568 SGWKGTECDVPTTQCID----PQCGGRGICIMGS--------CACNSGYKGESCEEADCI 615
            GW G  CD   + C +    P C     C  G+        C C  G++G +C+     
Sbjct: 561 PGWSGVHCD---SVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRI--C 615

Query: 616 DPGCSNH-------------GVCIH--GECHCSPGWGGSNCEILKTMCPD---------- 650
            PG   H             G C H  G C C PG+ G+ C     +CP           
Sbjct: 616 SPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCN---EVCPSGRFGKNCAGI 672

Query: 651 -QCSGHGTYLQESGSCTCDPNWTGPDCS----------NEICSVDCGSHGVCMG--GTCR 697
             C+ +GT      SC C P W G DCS          N I + +C +   C    G C+
Sbjct: 673 CTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECK 732

Query: 698 CEEGWTGPACNQR----------ACHPRCAEHGTCK--DGKCECSQGWNGEHCTIE---- 741
           C  GWTG  C QR          A   +C     C    G+C C  G+ G HC  +    
Sbjct: 733 CTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSG 792

Query: 742 ----GCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVA 776
               GC  +C+     T D     C C PGW+GA CD A
Sbjct: 793 TYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQA 831



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 84/297 (28%), Positives = 106/297 (35%), Gaps = 70/297 (23%)

Query: 516 VECPRNC---HGNG-ECVSGTCHCFPGFLGPDCS----------RAACPVLCSGNGQYSK 561
           + C   C   H +G    +G C C PG+ G  C             + P  C      S 
Sbjct: 536 LNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSP 595

Query: 562 --GRCLCFSGWKGTECDVPTT------QCID--PQC-GGRGIC--IMGSCACNSGYKGES 608
             G C C  G++GT C    +      +C    PQC    G C  I G C C  G+ G  
Sbjct: 596 DDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGAL 655

Query: 609 CEEA--------DCIDP-GCSNHGVC--IHGECHCSPGWGGSNCEI------LKTMCPDQ 651
           C E         +C     C+N+G C  I   C C PGW GS+C            C   
Sbjct: 656 CNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHT 715

Query: 652 CSGH-GTYLQE-SGSCTCDPNWTGPDCSNE------------ICSVDCGSHGVCMGGTCR 697
           C+ H G +     G C C P WTG  C+              IC    G+    + G C 
Sbjct: 716 CNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCT 775

Query: 698 CEEGWTGPACNQRA--------CHP--RCAEHGTCKD--GKCECSQGWNGEHCTIEG 742
           C  G+ G  C Q+         C     C  + TC    G C CS GW G  C   G
Sbjct: 776 CRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAG 832



 Score = 81.6 bits (200), Expect = 9e-15
 Identities = 67/260 (25%), Positives = 90/260 (34%), Gaps = 97/260 (37%)

Query: 610 EEADCIDPGCSNHGVCIHGEC------HCSPGWGGSNCE--------------------- 642
           E  +   P C++   C+HG C       C PGWGG+NC                      
Sbjct: 100 ESGEMCVPHCADK--CVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNG 157

Query: 643 ---------------ILKTMCPDQCSGHGTYLQE----------------SGSCTCDPNW 671
                               C D+C   GTY  +                +G C C P +
Sbjct: 158 ALCNPITGACHCAAGFRGWRCEDRCE-QGTYGNDCHQRCQCQNGATCDHVTGECRCPPGY 216

Query: 672 TGPDCSNEIC-----------SVDCGSHGVC--MGGTCRCEEGWTGPACNQ--------R 710
           TG  C  ++C              C + GVC  + G C C  GW G  C Q        +
Sbjct: 217 TGAFC-EDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGK 275

Query: 711 ACHPRCAEH--GTC--KDGKCECSQGWNGEHCTIEGCP-----GLCNSNGRCTLDQNGWH 761
            C   C  H  GTC    G+C CS G+ GE C  E CP      LC    +C      +H
Sbjct: 276 NCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDE-CPVGTYGVLCAETCQCVNGGKCYH 334

Query: 762 ----CVCQPGWRGAGCDVAM 777
               C+C+ G+ G  C+  +
Sbjct: 335 VSGACLCEAGFAGERCEARL 354



 Score = 52.0 bits (123), Expect = 8e-06
 Identities = 38/127 (29%), Positives = 55/127 (43%), Gaps = 29/127 (22%)

Query: 521 NCHGNGECVS--GTCHCFPGFLGPDCSRAA--------CPVLCS-GNG---QYSKGRCLC 566
           NCH    C +  G C C PG+ G  C++          C ++C   NG    +  G+C C
Sbjct: 717 NCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTC 776

Query: 567 FSGWKGTECDVPTTQCIDPQCGG--RGIC----------IMGSCACNSGYKGESCEEADC 614
            +G+ G  C+    +C     G   R IC          I G+C C+ G+KG  C++A  
Sbjct: 777 RTGFMGRHCE---QKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGV 833

Query: 615 IDPGCSN 621
           I  G  N
Sbjct: 834 IIVGNLN 840



 Score = 37.0 bits (84), Expect = 0.26
 Identities = 27/89 (30%), Positives = 35/89 (39%), Gaps = 21/89 (23%)

Query: 726 KCECSQGW--NGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTD 783
           K +C  G+  +GE C +  C   C  +GRC        C C+PGW G  C  A       
Sbjct: 91  KSQCCPGFYESGEMC-VPHCADKC-VHGRCIAPNT---CQCEPGWGGTNCSSAC------ 139

Query: 784 SKDNEGDGLIDCMDPDCCLQSSCQNQPYC 812
                 DG  D   P C  +  C+N   C
Sbjct: 140 ------DG--DHWGPHCTSRCQCKNGALC 160


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  139 bits (351), Expect = 3e-32
 Identities = 97/308 (31%), Positives = 132/308 (42%), Gaps = 47/308 (15%)

Query: 531 GTCHCFPGFLGPDCSRAACPVLCS--GNGQYSKGRCLCFSGWKGTECD--VPTTQCIDPQ 586
           G   C  G++G +C  A C   C+    G    G C C  GW+G  CD  VP   C+   
Sbjct: 227 GNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCV--- 283

Query: 587 CGGRGICI-MGSCACNSGYKGESCEEADCIDPG----CSNHGVCIHGE-----CHCSPGW 636
               G C+    C C + + G  C++ D    G    C+N G CI+ E     C C  G+
Sbjct: 284 ---HGSCVEPWQCNCETNWGGLLCDK-DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY 339

Query: 637 GGSNCEILKTMCPDQCSGHGTYLQESGS---CTCDPNWTGPDCS---NEICSVDCGSHGV 690
            G NCE  +  C      +G    E  S   C C   W+GP C+   +E  S  C + G 
Sbjct: 340 SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGT 399

Query: 691 CM----GGTCRCEEGWTGPAC--NQRACHPRCAEHGTCKD----GKCECSQGWNGEHCTI 740
           C+    G  C C E W G  C  +   C  +C   GTCKD     +C C +G+ G HC +
Sbjct: 400 CVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459

Query: 741 EG---CPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEG------DG 791
           E        C+S G C    +G+HC C  G+ G  C+V ++ LC  S    G      +G
Sbjct: 460 ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVD-LCEPSPCRNGARCYNLEG 518

Query: 792 LIDCMDPD 799
              C  PD
Sbjct: 519 DYYCACPD 526



 Score =  126 bits (317), Expect = 3e-28
 Identities = 90/295 (30%), Positives = 126/295 (42%), Gaps = 46/295 (15%)

Query: 562 GRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCID-PGCS 620
           G   C  GW G EC     +       G G  + G C C+ G++G  C+E  C+  PGC 
Sbjct: 227 GNKACMDGWMGKECKEAVCKQGCNLLHG-GCTVPGECRCSYGWQGRFCDE--CVPYPGCV 283

Query: 621 NHGVCIHG-ECHCSPGWGGSNCEILKTMCPDQ--CSGHGTYLQ---ESGSCTCDPNWTGP 674
            HG C+   +C+C   WGG  C+     C     C+  GT +    +   CTC   ++G 
Sbjct: 284 -HGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGR 342

Query: 675 DCS---NEICSVDCGSHGVC----MGGTCRCEEGWTGPAC----NQRACHPRCAEHGTCK 723
           +C    +   S  C + G C     G  C C  GW+GP C    ++ A +P CA  GTC 
Sbjct: 343 NCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP-CAAGGTCV 401

Query: 724 DG----KCECSQGWNGEHCTIE--GCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAM 777
           D     +C C + W G  C ++   C G C   G C    NG+ CVC  G+ G  C++  
Sbjct: 402 DQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELER 461

Query: 778 ET----------LCTDSKDN------EG-DGLIDCMDPDCCLQSSCQNQPYCRGL 815
           +           LC D  D       +G  G +  +D D C  S C+N   C  L
Sbjct: 462 DECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNL 516



 Score =  125 bits (314), Expect = 6e-28
 Identities = 94/294 (31%), Positives = 119/294 (40%), Gaps = 46/294 (15%)

Query: 522 CHGNGECVSG-----TCHCFPGFLGPDCSRAACPVL---CSGNG----QYSKGRCLCFSG 569
           C  +G CVS      +C C  GF G  C       L   C   G    +    RC C SG
Sbjct: 568 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSG 627

Query: 570 WKGTECDVPTTQCIDPQCGGRGIC--IMGS--CACNSGYKGESC--EEADCIDPGCSNHG 623
           W+G  CD     C+   C  RG C  ++    CAC+ G+KG++C   E  C    CSN G
Sbjct: 628 WEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGG 687

Query: 624 VCIHG----ECHCSPGWGGSNCEILK--TMCPDQCSGHGTYLQE--SGSCTCDPNWTGPD 675
            C        C C PGW GS C + K  +  P+ C   GT +    S SC C   W G  
Sbjct: 688 TCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRT 747

Query: 676 C---SNEICSVDCGSHGVCMGGT----CRCEEGWTGPAC--NQRACHPR-CAEHGTCKDG 725
           C   +N+   + C + G+C+ G     C C  G+ GP C  N   C    CA   TC D 
Sbjct: 748 CTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDE 807

Query: 726 ----KCECSQGWNGEHC-TIEGCPGLCNSNGRCTLDQNGW-----HCVCQPGWR 769
               +C C  G  G  C  + G    C S G      + W      C C  G R
Sbjct: 808 INGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRR 861



 Score =  122 bits (307), Expect = 4e-27
 Identities = 84/295 (28%), Positives = 111/295 (37%), Gaps = 35/295 (11%)

Query: 518 CPRNC---HGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           C + C   HG G  V G C C  G+ G  C        C         +C C + W G  
Sbjct: 245 CKQGCNLLHG-GCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLL 303

Query: 575 CDVPTTQC-IDPQCGGRGICIMGS-----CACNSGYKGESCEEAD--CIDPGCSNHGVCI 626
           CD     C     C   G CI        C C  GY G +CE+A+  C    C+N G C 
Sbjct: 304 CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH 363

Query: 627 H----GECHCSPGWGGSNCEI-LKTMCPDQCSGHGTYLQ--ESGSCTCDPNWTGPDCSNE 679
                 ECHC  GW G  C + +     + C+  GT +   +   C C   W G  C  +
Sbjct: 364 EVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD 423

Query: 680 I--CSVDCGSHGVCM----GGTCRCEEGWTGPAC---NQRACHPRCAEHGTCKD----GK 726
           +  C   C   G C     G  C C  G+ G  C           C   G C+D      
Sbjct: 424 VNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFH 483

Query: 727 CECSQGWNGEHCTIEG--C-PGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAME 778
           C C QG++G  C ++   C P  C +  RC   +  ++C C   + G  C V  E
Sbjct: 484 CHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPRE 538



 Score =  122 bits (305), Expect = 6e-27
 Identities = 96/362 (26%), Positives = 131/362 (36%), Gaps = 74/362 (20%)

Query: 517 ECPRN-CHGNGECVSGT----CHCFPGFLGPDCSRAA--CPVLCSGNGQ----YSKGRCL 565
           EC  N C   G CV       C C   ++G  C      C   C   G      +  +C+
Sbjct: 388 ECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCV 447

Query: 566 CFSGWKGTECDVPTTQCIDPQCGGRGICIMGS----CACNSGYKGESCE-EADCIDPG-C 619
           C  G+ G  C++   +C    C   G+C   +    C C  G+ G  CE + D  +P  C
Sbjct: 448 CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPC 507

Query: 620 SNHGVCIHGE----CHCSPGWGGSNCEILKTMCPDQ------------------------ 651
            N   C + E    C C   +GG NC + +  CP                          
Sbjct: 508 RNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGV 567

Query: 652 CSGHGTYLQESG---SCTCDPNWTGPDCSNEI---CSVDCGSHGVCMGGT----CRCEEG 701
           C  HG  + + G   SC CD  +TG  C   I       C + G C+       C C  G
Sbjct: 568 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSG 627

Query: 702 WTGPAC--NQRACHPR-CAEHGTC----KDGKCECSQGWNGEHCTIEG--CPGL-CNSNG 751
           W G  C  N   C P  C   G C     D  C C  GW G+ C      C    C++ G
Sbjct: 628 WEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGG 687

Query: 752 RCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPY 811
            C    + + C C PGW+G+ C VA  + C  +          C++   C+ S       
Sbjct: 688 TCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPN---------PCVNGGTCVGSGASFSCI 738

Query: 812 CR 813
           CR
Sbjct: 739 CR 740



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 44/139 (31%), Positives = 63/139 (45%), Gaps = 11/139 (7%)

Query: 654 GHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGS-HGVC-MGGTCRCEEGWTGPACNQRA 711
           GH T   + G+  C   W G +C   +C   C   HG C + G CRC  GW G  C++  
Sbjct: 219 GHYT-CDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECV 277

Query: 712 CHPRCAEHGTC-KDGKCECSQGWNGEHCTIE----GCPGLCNSNGRC-TLDQNGWHCVCQ 765
            +P C  HG+C +  +C C   W G  C  +    G    C + G C   + + + C C 
Sbjct: 278 PYPGCV-HGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336

Query: 766 PGWRGAGCDVAMETLCTDS 784
            G+ G  C+ A E  CT +
Sbjct: 337 DGYSGRNCEKA-EHACTSN 354



 Score = 68.9 bits (167), Expect = 6e-11
 Identities = 53/188 (28%), Positives = 67/188 (35%), Gaps = 29/188 (15%)

Query: 653 SGHGTYLQESGSCTCDPNWTGPDCSNEICSV--DCGSHGVC-MGGTCRCEEGWTGPACNQ 709
           SGH  +L+      CD N+    C N+ C    D   H  C   G   C +GW G  C +
Sbjct: 184 SGHVAHLELQIRVRCDENYYSATC-NKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKE 242

Query: 710 RACHPRC-AEHGTCK-DGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPG 767
             C   C   HG C   G+C CS GW G  C  E  P     +G C      W C C+  
Sbjct: 243 AVCKQGCNLLHGGCTVPGECRCSYGWQGRFCD-ECVPYPGCVHGSCV---EPWQCNCETN 298

Query: 768 WRGAGCDVAMETLCTDSKDNEGDGLID-------CMDPD------------CCLQSSCQN 808
           W G  CD  +    +      G   I+       C  PD             C  + C N
Sbjct: 299 WGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCAN 358

Query: 809 QPYCRGLP 816
              C  +P
Sbjct: 359 GGSCHEVP 366


>gi|157384973 tenascin R [Homo sapiens]
          Length = 1358

 Score =  139 bits (351), Expect = 3e-32
 Identities = 65/162 (40%), Positives = 83/162 (51%), Gaps = 7/162 (4%)

Query: 585 PQCGGRGICIMGSCAC--NSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCE 642
           P C G G     SC C  N G+ G++C E  C   GCS+ GVC+ G+C C   + G +C 
Sbjct: 173 PHCSGHGNFSFESCGCICNEGWFGKNCSEPYC-PLGCSSRGVCVDGQCICDSEYSGDDCS 231

Query: 643 ILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGW 702
            L+  CP  CS  G  L   G C C+  +TG DC    C  DC   G C  GTC CEEG+
Sbjct: 232 ELR--CPTDCSSRG--LCVDGECVCEEPYTGEDCRELRCPGDCSGKGRCANGTCLCEEGY 287

Query: 703 TGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCP 744
            G  C QR C   C+  G C++G C C +G+ G  C+    P
Sbjct: 288 VGEDCGQRQCLNACSGRGQCEEGLCVCEEGYQGPDCSAVAPP 329



 Score =  122 bits (305), Expect = 6e-27
 Identities = 58/170 (34%), Positives = 84/170 (49%), Gaps = 12/170 (7%)

Query: 652 CSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRA 711
           CSGHG +  ES  C C+  W G +CS   C + C S GVC+ G C C+  ++G  C++  
Sbjct: 175 CSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELR 234

Query: 712 CHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGA 771
           C   C+  G C DG+C C + + GE C    CPG C+  GRC    NG  C+C+ G+ G 
Sbjct: 235 CPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGRCA---NG-TCLCEEGYVGE 290

Query: 772 GCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDI 821
            C    +  C ++    G     C +  C  +   Q  P C  +  P+D+
Sbjct: 291 DCG---QRQCLNACSGRG----QCEEGLCVCEEGYQG-PDCSAVAPPEDL 332



 Score =  106 bits (265), Expect = 3e-22
 Identities = 64/211 (30%), Positives = 91/211 (43%), Gaps = 7/211 (3%)

Query: 431 YGRKGLPPSHTQYDFVELLDGSRLIAREQRSLLETERAGRQARSVSLHEAGFIQYLDSGI 490
           + +K  P + +     ELL    ++ RE   L +   A     S +  +  +I +  SG 
Sbjct: 120 FPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNANCCQESAATGQLDYIPHC-SGH 178

Query: 491 WHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACP 550
            + +F + G    +  F     E    CP  C   G CV G C C   + G DCS   CP
Sbjct: 179 GNFSFESCGCICNEGWFGKNCSEPY--CPLGCSSRGVCVDGQCICDSEYSGDDCSELRCP 236

Query: 551 VLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCE 610
             CS  G    G C+C   + G +C     +C    C G+G C  G+C C  GY GE C 
Sbjct: 237 TDCSSRGLCVDGECVCEEPYTGEDC--RELRC-PGDCSGKGRCANGTCLCEEGYVGEDCG 293

Query: 611 EADCIDPGCSNHGVCIHGECHCSPGWGGSNC 641
           +  C++  CS  G C  G C C  G+ G +C
Sbjct: 294 QRQCLN-ACSGRGQCEEGLCVCEEGYQGPDC 323



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 16/34 (47%), Positives = 19/34 (55%)

Query: 517 ECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACP 550
           +C   C G G+C  G C C  G+ GPDCS  A P
Sbjct: 296 QCLNACSGRGQCEEGLCVCEEGYQGPDCSAVAPP 329


>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
          Length = 1044

 Score =  139 bits (351), Expect = 3e-32
 Identities = 108/382 (28%), Positives = 147/382 (38%), Gaps = 109/382 (28%)

Query: 516 VECPRNCHGNGEC--VSGTCHCFPGFLGPDCSRAA------------CPVLCSGNGQYSK 561
           + CP  C   G C  ++G C C PG+ G  C++              CP    G   +  
Sbjct: 230 LRCP--CQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVT 287

Query: 562 GRCLCFSGWKGTECD---------VPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEA 612
           G+C C +G+ G  C             +Q  D   GG+     G+C C  GYKG  C+E 
Sbjct: 288 GQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQER 347

Query: 613 DCID----PGCSNHGVC----------IHGECHCSPGWGGSNCEILKTMCPDQCSGHGTY 658
            C +    PGC+    C          + G C C PGW G +C      CP    G G  
Sbjct: 348 LCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHC---NESCPVGYYGDGCQ 404

Query: 659 L-----------QESGSCTCDPNWT-------------GPDCSNEICSVDCGSHGVC--M 692
           L             +G CTC P +              GP+CS+ ICS  C + G C  +
Sbjct: 405 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSS-ICS--CNNGGTCSPV 461

Query: 693 GGTCRCEEGWTGPACN------------QRACHPRCAEHGTCK--DGKCECSQGWNGEHC 738
            G+C C+EGW G  C               +C   CA    C   DG C C+ GW G+ C
Sbjct: 462 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESC--TCANGAACSPIDGSCSCTPGWLGDTC 519

Query: 739 TI---EGCPGL-CNSNGRCT----LDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGD 790
            +   +G  GL C+ +  C+     D    HC C  GW G  CD    + C   +     
Sbjct: 520 ELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCD----STCPPGR----- 570

Query: 791 GLIDCMDPDCCLQSSCQNQPYC 812
                  P+C +  SC+N   C
Sbjct: 571 -----WGPNCSVSCSCENGGSC 587



 Score =  135 bits (341), Expect = 4e-31
 Identities = 102/357 (28%), Positives = 132/357 (36%), Gaps = 97/357 (27%)

Query: 512 IESVVECPR-----NCHGNGEC--------VSGTCHCFPGFLGPDCSRAACP-----VLC 553
           ++  + CP      NC+ +  C        + G+C C PG+LG  C    CP     + C
Sbjct: 474 LDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCE-LPCPDGTFGLNC 532

Query: 554 SGNGQYSK--------GRCLCFSGWKGTECDVPTTQ-------CIDPQCGGRGICIM--G 596
           S +   S         G C C +GW G  CD             +   C   G C    G
Sbjct: 533 SEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDG 592

Query: 597 SCACNSGYKGESCEEADCIDPGCSNHG------VCIH---------GECHCSPGWGGSNC 641
           SC C  G++G  C+      PG   HG      +C+H         G C C PG+ G+ C
Sbjct: 593 SCECAPGFRGPLCQRI--CPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALC 650

Query: 642 EIL----------KTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSN------------E 679
             +            +C   C+ +GT     GSC C P W G DCS              
Sbjct: 651 NQVCAGGYFGQDCAQLC--SCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFH 708

Query: 680 ICSVDCGSHGVCMGGTCRCEEGWTGPACNQRA--------CHPRC-AEHGTCKD---GKC 727
            CS   G+      G C C  GWTG  C QR         C   C  ++G   D   GKC
Sbjct: 709 ACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKC 768

Query: 728 ECSQGWNGEHCTIE--------GCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVA 776
            C  G+ G+HC           GC  LC      T D     C C PG++G  CD A
Sbjct: 769 TCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQA 825



 Score =  134 bits (337), Expect = 1e-30
 Identities = 115/373 (30%), Positives = 134/373 (35%), Gaps = 95/373 (25%)

Query: 518 CPRNCHGNGECVS-GTCHCFPGFLGPDCSRAA--------CPVLCS-GNGQYSK---GRC 564
           C   C  +G CVS  TCHC PG+ GPDCS           C   C   NG       G C
Sbjct: 103 CTEECV-HGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGAC 161

Query: 565 LCFSGWKGTECD---VPTTQ---CIDP-QCGGRGIC--IMGSCACNSGYKGESCEE---- 611
           +C +G++G  C+    P T    C  P QC     C    G C C  GY G  CEE    
Sbjct: 162 VCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPP 221

Query: 612 ----ADC-IDPGCSNHGVCIH--GECHCSPGWGGSNCE------ILKTMCPDQCSGH--G 656
               A C +   C N G C H  GEC C PGW G+ C            C   C  H  G
Sbjct: 222 GSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGG 281

Query: 657 TYLQESGSCTCDPNWTGPDCSNEI--------CSVDCGSH--GVC--MGGTCRCEEGWTG 704
                +G C C   + G  C  E         CS  C  H  G C    G C CE G+ G
Sbjct: 282 QCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKG 341

Query: 705 PACNQRAC-----HPRCAEHGTCK----------DGKCECSQGWNGEHCTI--------E 741
           P C +R C      P C     C            G C C  GW+G HC          +
Sbjct: 342 PRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGD 401

Query: 742 GC--PGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPD 799
           GC  P  C +   C     G  C C PG+ G  C V+                     P+
Sbjct: 402 GCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAVSCAA--------------GTYGPN 445

Query: 800 CCLQSSCQNQPYC 812
           C    SC N   C
Sbjct: 446 CSSICSCNNGGTC 458



 Score =  125 bits (313), Expect = 7e-28
 Identities = 112/424 (26%), Positives = 146/424 (34%), Gaps = 115/424 (27%)

Query: 478 HEAGFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGEC--VSGTCHC 535
           H  G   ++       A Y   +  E+  F +   +    C  +CH  G+C   +G C C
Sbjct: 278 HHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHC--DCHNGGQCSPTTGACEC 335

Query: 536 FPGFLGPDCSRAACPVLCSGNG---------------QYSKGRCLCFSGWKGTECD---- 576
            PG+ GP C    CP    G G                   G C C  GW G  C+    
Sbjct: 336 EPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCP 395

Query: 577 ---------VPTTQCIDPQCGGRGICIMGSCACNSGYKGESCE---EADCIDPGCS---- 620
                    +P T C   Q G     I G C C  G+ GE C     A    P CS    
Sbjct: 396 VGYYGDGCQLPCT-C---QNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICS 451

Query: 621 --NHGVC--IHGECHCSPGWGGSNCEILKTMCPD-----------QCSGHGTYLQESGSC 665
             N G C  + G C C  GW G +C +    CP             C+         GSC
Sbjct: 452 CNNGGTCSPVDGSCTCKEGWQGLDCTL---PCPSGTWGLNCNESCTCANGAACSPIDGSC 508

Query: 666 TCDPNWTGPDCS----NEICSVDCGSHGVC--------MGGTCRCEEGWTGPACNQRACH 713
           +C P W G  C     +    ++C  H  C        + G C C  GWTG  C+   C 
Sbjct: 509 SCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDS-TCP 567

Query: 714 P-----------RCAEHGTC--KDGKCECSQGWNGEHC------------TIEGCPGLCN 748
           P            C   G+C  +DG CEC+ G+ G  C              + CP LC 
Sbjct: 568 PGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCP-LCV 626

Query: 749 SNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQN 808
            + R     +G  C C PG+ GA C+     +C      +          DC    SC N
Sbjct: 627 HSSRPCHHISG-ICECLPGFSGALCN----QVCAGGYFGQ----------DCAQLCSCAN 671

Query: 809 QPYC 812
              C
Sbjct: 672 NGTC 675



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 71/233 (30%), Positives = 92/233 (39%), Gaps = 67/233 (28%)

Query: 518 CPRNCHGNGEC--VSGTCHCFPGFLGPDCSRAA--------CPVLCS--GNGQYSK--GR 563
           CP   H +  C  +SG C C PGF G  C++          C  LCS   NG  S   G 
Sbjct: 622 CPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGS 681

Query: 564 CLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHG 623
           C CF GW G +C    +Q   P  G  G     +C+C++G    SC   D          
Sbjct: 682 CQCFPGWIGKDC----SQACPP--GFWGPACFHACSCHNG---ASCSAED---------- 722

Query: 624 VCIHGECHCSPGWGGSNCEILKTMCPD-----------QCSGHGTYLQESGSCTCDPNWT 672
               G CHC+PGW G  C      CP            QC    +    SG CTC   +T
Sbjct: 723 ----GACHCTPGWTGLFCT---QRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFT 775

Query: 673 GPDCSN------------EICSVDCGSHGVC--MGGTCRCEEGWTGPACNQRA 711
           G  C              ++C  +C ++  C  + GTC C  G+ G  C+Q A
Sbjct: 776 GQHCEQRCAPGTFGYGCQQLC--ECMNNSTCDHVTGTCYCSPGFKGIRCDQAA 826



 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 59/188 (31%), Positives = 78/188 (41%), Gaps = 31/188 (16%)

Query: 600 CNSGYKGESCEEADCIDPGCSNHGVCIHGEC------HCSPGWGGSNC------EILKTM 647
           C  GY     E  D   P C+    C+HG C      HC PGWGG +C      +     
Sbjct: 88  CCPGYY----ESGDFCIPLCTEE--CVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPH 141

Query: 648 CPDQCSGHGTYLQE--SGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGP 705
           C ++C      L    +G+C C   + G  C  E+C+   G+HG      C+C     G 
Sbjct: 142 CSNRCQCQNGALCNPITGACVCAAGFRGWRC-EELCAP--GTHGKGCQLPCQCRH---GA 195

Query: 706 ACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQ 765
           +C+ RA    CA   T    +  C  G +G HC +  CP  C + G C        C C 
Sbjct: 196 SCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELR-CP--CQNGGTC--HHITGECACP 250

Query: 766 PGWRGAGC 773
           PGW GA C
Sbjct: 251 PGWTGAVC 258


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  139 bits (349), Expect = 5e-32
 Identities = 99/322 (30%), Positives = 128/322 (39%), Gaps = 42/322 (13%)

Query: 518 CPRNC---HGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           C + C   HG G  V G C C  G+ G  C        C         +C C + W G  
Sbjct: 245 CKQGCNLLHG-GCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLL 303

Query: 575 CDVPTTQC-IDPQCGGRGICIMGS-----CACNSGYKGESCEEAD--CIDPGCSNHGVCI 626
           CD     C     C   G CI        C C  GY G +CE+A+  C    C+N G C 
Sbjct: 304 CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH 363

Query: 627 H----GECHCSPGWGGSNCEI-LKTMCPDQCSGHGTYLQ--ESGSCTCDPNWTGPDC--- 676
                 ECHC  GW G  C + +     + C+  GT +   +   C C   W G  C   
Sbjct: 364 EVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD 423

Query: 677 SNEICSVDCGSHGVCM----GGTCRCEEGWTGPAC--NQRACHPRCAEHGTCKD----GK 726
           +NE     C +   C     G  C C  GW G  C  N   C  +C   GTCKD     +
Sbjct: 424 ANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQ 483

Query: 727 CECSQGWNGEHCTIEG---CPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTD 783
           C C +G+ G HC +E        C+S G C    +G+HC C  G+ G  C+V ++ LC  
Sbjct: 484 CVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVD-LCEP 542

Query: 784 SKDNEG------DGLIDCMDPD 799
           S    G      +G   C  PD
Sbjct: 543 SPCRNGARCYNLEGDYYCACPD 564



 Score =  125 bits (314), Expect = 6e-28
 Identities = 94/294 (31%), Positives = 119/294 (40%), Gaps = 46/294 (15%)

Query: 522 CHGNGECVSG-----TCHCFPGFLGPDCSRAACPVL---CSGNG----QYSKGRCLCFSG 569
           C  +G CVS      +C C  GF G  C       L   C   G    +    RC C SG
Sbjct: 606 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSG 665

Query: 570 WKGTECDVPTTQCIDPQCGGRGIC--IMGS--CACNSGYKGESC--EEADCIDPGCSNHG 623
           W+G  CD     C+   C  RG C  ++    CAC+ G+KG++C   E  C    CSN G
Sbjct: 666 WEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGG 725

Query: 624 VCIHG----ECHCSPGWGGSNCEILK--TMCPDQCSGHGTYLQE--SGSCTCDPNWTGPD 675
            C        C C PGW GS C + K  +  P+ C   GT +    S SC C   W G  
Sbjct: 726 TCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRT 785

Query: 676 C---SNEICSVDCGSHGVCMGGT----CRCEEGWTGPAC--NQRACHPR-CAEHGTCKDG 725
           C   +N+   + C + G+C+ G     C C  G+ GP C  N   C    CA   TC D 
Sbjct: 786 CTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDE 845

Query: 726 ----KCECSQGWNGEHC-TIEGCPGLCNSNGRCTLDQNGW-----HCVCQPGWR 769
               +C C  G  G  C  + G    C S G      + W      C C  G R
Sbjct: 846 INGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRR 899



 Score =  123 bits (308), Expect = 3e-27
 Identities = 91/341 (26%), Positives = 126/341 (36%), Gaps = 69/341 (20%)

Query: 533 CHCFPGFLGPDCSRAA--CPVLCSGNGQ----YSKGRCLCFSGWKGTECDVPTTQCIDPQ 586
           C C PG+ G +C      C   C   G      +  +C+C  G+ G  C++   +C    
Sbjct: 447 CDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP 506

Query: 587 CGGRGICIMGS----CACNSGYKGESCE-EADCIDPG-CSNHGVCIHGE----CHCSPGW 636
           C   G+C   +    C C  G+ G  CE + D  +P  C N   C + E    C C   +
Sbjct: 507 CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 566

Query: 637 GGSNCEILKTMCPDQ------------------------CSGHGTYLQESG---SCTCDP 669
           GG NC + +  CP                          C  HG  + + G   SC CD 
Sbjct: 567 GGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDS 626

Query: 670 NWTGPDCSNEI---CSVDCGSHGVCMGGT----CRCEEGWTGPAC--NQRACHPR-CAEH 719
            +TG  C   I       C + G C+       C C  GW G  C  N   C P  C   
Sbjct: 627 GFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSR 686

Query: 720 GTC----KDGKCECSQGWNGEHCTIEG--CPGL-CNSNGRCTLDQNGWHCVCQPGWRGAG 772
           G C     D  C C  GW G+ C      C    C++ G C    + + C C PGW+G+ 
Sbjct: 687 GRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGST 746

Query: 773 CDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCR 813
           C VA  + C  +          C++   C+ S       CR
Sbjct: 747 CAVAKNSSCLPN---------PCVNGGTCVGSGASFSCICR 778



 Score =  118 bits (296), Expect = 7e-26
 Identities = 87/297 (29%), Positives = 124/297 (41%), Gaps = 46/297 (15%)

Query: 562 GRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCID-PGCS 620
           G   C  GW G EC     +       G G  + G C C+ G++G  C+E  C+  PGC 
Sbjct: 227 GNKACMDGWMGKECKEAVCKQGCNLLHG-GCTVPGECRCSYGWQGRFCDE--CVPYPGCV 283

Query: 621 NHGVCIHG-ECHCSPGWGGSNCEILKTMCPDQ--CSGHGTYLQ---ESGSCTCDPNWTGP 674
            HG C+   +C+C   WGG  C+     C     C+  GT +    +   CTC   ++G 
Sbjct: 284 -HGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGR 342

Query: 675 DCS---NEICSVDCGSHGVC----MGGTCRCEEGWTGPAC----NQRACHPRCAEHGTCK 723
           +C    +   S  C + G C     G  C C  GW+GP C    ++ A +P CA  GTC 
Sbjct: 343 NCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP-CAAGGTCV 401

Query: 724 DG----KCECSQGWNGEHCTIEG--CPGL-CNSNGRCTLDQNGWHCVCQPGWRGAGCDVA 776
           D     +C C + W G  C ++   C G  C +   C     G++C C PGW+G  C + 
Sbjct: 402 DQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHIN 461

Query: 777 MET---------LCTDSKDN------EGDGLIDC-MDPDCCLQSSCQNQPYCRGLPD 817
           +            C D  +        G G   C ++ D C  S C +   C  L D
Sbjct: 462 VNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD 518



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 44/139 (31%), Positives = 63/139 (45%), Gaps = 11/139 (7%)

Query: 654 GHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGS-HGVC-MGGTCRCEEGWTGPACNQRA 711
           GH T   + G+  C   W G +C   +C   C   HG C + G CRC  GW G  C++  
Sbjct: 219 GHYT-CDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECV 277

Query: 712 CHPRCAEHGTC-KDGKCECSQGWNGEHCTIE----GCPGLCNSNGRC-TLDQNGWHCVCQ 765
            +P C  HG+C +  +C C   W G  C  +    G    C + G C   + + + C C 
Sbjct: 278 PYPGCV-HGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336

Query: 766 PGWRGAGCDVAMETLCTDS 784
            G+ G  C+ A E  CT +
Sbjct: 337 DGYSGRNCEKA-EHACTSN 354



 Score = 68.9 bits (167), Expect = 6e-11
 Identities = 53/188 (28%), Positives = 67/188 (35%), Gaps = 29/188 (15%)

Query: 653 SGHGTYLQESGSCTCDPNWTGPDCSNEICSV--DCGSHGVC-MGGTCRCEEGWTGPACNQ 709
           SGH  +L+      CD N+    C N+ C    D   H  C   G   C +GW G  C +
Sbjct: 184 SGHVAHLELQIRVRCDENYYSATC-NKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKE 242

Query: 710 RACHPRC-AEHGTCK-DGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPG 767
             C   C   HG C   G+C CS GW G  C  E  P     +G C      W C C+  
Sbjct: 243 AVCKQGCNLLHGGCTVPGECRCSYGWQGRFCD-ECVPYPGCVHGSCV---EPWQCNCETN 298

Query: 768 WRGAGCDVAMETLCTDSKDNEGDGLID-------CMDPD------------CCLQSSCQN 808
           W G  CD  +    +      G   I+       C  PD             C  + C N
Sbjct: 299 WGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCAN 358

Query: 809 QPYCRGLP 816
              C  +P
Sbjct: 359 GGSCHEVP 366


>gi|4758614 integrin, beta-like 1 (with EGF-like repeat domains)
           [Homo sapiens]
          Length = 494

 Score =  139 bits (349), Expect = 5e-32
 Identities = 108/379 (28%), Positives = 137/379 (36%), Gaps = 101/379 (26%)

Query: 522 CHGNGECVSGTCHCF---PG-FLGP--DCSRAACPVL----CSGNGQYSKGRCLCFSGWK 571
           CHG G C  G C C    PG F GP  +C    C       C+G+G+   G+C C  GW 
Sbjct: 63  CHGRGRCDCGVCICHVTEPGMFFGPLCECHEWVCETYDGSTCAGHGKCDCGKCKCDQGWY 122

Query: 572 GTECDVPTT----------QCIDPQ---CGGRGICIMGSCAC-NSGYKGE------SCEE 611
           G  C  PT            C + Q   C   G C  G C C NS   G        C++
Sbjct: 123 GDACQYPTNCDLTKKKSNQMCKNSQDIICSNAGTCHCGRCKCDNSDGSGLVYGKFCECDD 182

Query: 612 ADCIDPG----CSNHGVCIHGECHCSPGWGGSNCEILKTMCPDQ------------CSGH 655
            +CID      C  HG C  G C+C  GW G  CE    + P +            CS  
Sbjct: 183 RECIDDETEEICGGHGKCYCGNCYCKAGWHGDKCEFQCDITPWESKRRCTSPDGKICSNR 242

Query: 656 GTYLQESGSCTC---DPNWTGPDCSNEICSVD---------------CGSHGVCMGGTCR 697
           GT +   G CTC   DP     D   + C  D               C  HG C  G C 
Sbjct: 243 GTCV--CGECTCHDVDPTGDWGDIHGDTCECDERDCRAVYDRYSDDFCSGHGQCNCGRCD 300

Query: 698 CEEGWTGPACNQ------------RACHPR----CAEHGTCKDGKCEC----SQGWNGEH 737
           C+ GW G  C              R C       C+  G C+ GKC C     +   G+ 
Sbjct: 301 CKAGWYGKKCEHPQSCTLSAEESIRKCQGSSDLPCSGRGKCECGKCTCYPPGDRRVYGKT 360

Query: 738 CTIEG--CPGL----CNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKD----N 787
           C  +   C  L    C  +G C+  +    CVC+ GW G  C    +   T+ +      
Sbjct: 361 CECDDRRCEDLDGVVCGGHGTCSCGR----CVCERGWFGKLCQHPRKCNMTEEQSKNLCE 416

Query: 788 EGDGLIDCMDPDCCLQSSC 806
             DG++ C     C    C
Sbjct: 417 SADGIL-CSGKGSCHCGKC 434



 Score =  132 bits (333), Expect = 4e-30
 Identities = 100/347 (28%), Positives = 128/347 (36%), Gaps = 103/347 (29%)

Query: 522 CHGNGECVSGTCHC------------FPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSG 569
           C   G C  G C C            F      +C       +C G+G+   G C C +G
Sbjct: 151 CSNAGTCHCGRCKCDNSDGSGLVYGKFCECDDRECIDDETEEICGGHGKCYCGNCYCKAG 210

Query: 570 WKGTECDVPTT--------QCIDPQ---CGGRGICIMGSCACNS--------GYKGESCE 610
           W G +C+            +C  P    C  RG C+ G C C+            G++CE
Sbjct: 211 WHGDKCEFQCDITPWESKRRCTSPDGKICSNRGTCVCGECTCHDVDPTGDWGDIHGDTCE 270

Query: 611 --EADC-------IDPGCSNHGVCIHGECHCSPGWGGSNCEILK--TMCPDQ-------- 651
             E DC        D  CS HG C  G C C  GW G  CE  +  T+  ++        
Sbjct: 271 CDERDCRAVYDRYSDDFCSGHGQCNCGRCDCKAGWYGKKCEHPQSCTLSAEESIRKCQGS 330

Query: 652 ----CSGHGTYLQESGSCTCDPNWTGP------DCSNEICS----VDCGSHGVCMGGTCR 697
               CSG G    E G CTC P           +C +  C     V CG HG C  G C 
Sbjct: 331 SDLPCSGRGKC--ECGKCTCYPPGDRRVYGKTCECDDRRCEDLDGVVCGGHGTCSCGRCV 388

Query: 698 CEEGWTGPACNQRACHPR--------------------CAEHGTCKDGKCECS-QGW--N 734
           CE GW G  C     HPR                    C+  G+C  GKC CS + W  +
Sbjct: 389 CERGWFGKLCQ----HPRKCNMTEEQSKNLCESADGILCSGKGSCHCGKCICSAEEWYIS 444

Query: 735 GEHCTIE--GCPG----LCNSNGRCTLDQNGWHCVCQPGWRGAGCDV 775
           GE C  +   C      +C  NG C+      +C C  GW G  C++
Sbjct: 445 GEFCDCDDRDCDKHDGLICTGNGICSCG----NCECWDGWNGNACEI 487



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 50/175 (28%), Positives = 67/175 (38%), Gaps = 34/175 (19%)

Query: 636 WGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGT 695
           W G+ C + +     +C   G   Q  G+  C       DC   IC V     G+  G  
Sbjct: 35  WPGAACRLSRAESERRCRAPG---QPPGAALCHGRGRC-DCGVCICHVT--EPGMFFGPL 88

Query: 696 CRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCN-----SN 750
           C C E W     +   C    A HG C  GKC+C QGW G+ C     P  C+     SN
Sbjct: 89  CECHE-WVCETYDGSTC----AGHGKCDCGKCKCDQGWYGDACQY---PTNCDLTKKKSN 140

Query: 751 GRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLI-----DCMDPDC 800
             C   +N    +C      AG        C +S   +G GL+     +C D +C
Sbjct: 141 QMC---KNSQDIICS----NAGTCHCGRCKCDNS---DGSGLVYGKFCECDDREC 185


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  135 bits (339), Expect = 7e-31
 Identities = 109/377 (28%), Positives = 135/377 (35%), Gaps = 86/377 (22%)

Query: 519 PRNCHGNGECVS-----GTCHCFPGFLGPDCS---RAACPVLCSGNGQYS---------- 560
           P  C   G C+S     GTC C PGFLG  C          LC   G             
Sbjct: 32  PEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLP 91

Query: 561 --------KGRCLCFSGWKGTECDVPTTQCIDPQ-CGGRGICIMGS-----CACNSGYKG 606
                      C C  G+ G  C         P  C  RG C + +     C+C  G+ G
Sbjct: 92  SSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTG 151

Query: 607 ESCEEAD-CIDPGCSNHGVCIHG----ECHCSPGWGGSNCEILKTMC-------PDQCSG 654
           E C+  D C    C N GVC+      +CHC PG+ G  CE     C       P   S 
Sbjct: 152 EQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSC 211

Query: 655 HGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCR-------------CEEG 701
           H T    S  C C     GP C  E+ +  C   G   GGTC+             C  G
Sbjct: 212 HNTL--GSFQCLCPVGQEGPRC--ELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPG 267

Query: 702 WTGPACN---QRACHPRCAEHGTCKDG----KCECSQGWNGEHCT--IEGC----PGLCN 748
           + GP C          +C   GTC+DG     C C + W G  C+  ++ C    P  C 
Sbjct: 268 FIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCR 327

Query: 749 SNGRCTLDQNGWHCVCQPGWRGAGC-----DVAMETLCTDSKDNEGDGLIDCMDPD---- 799
           + G C      +HCVC  GW G  C     D    T    S   +  G   C+ P     
Sbjct: 328 NGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTG 387

Query: 800 --CCLQSSCQNQPYCRG 814
             C L+  C +QP C G
Sbjct: 388 LLCHLEDMCLSQP-CHG 403



 Score =  132 bits (331), Expect = 6e-30
 Identities = 99/352 (28%), Positives = 141/352 (40%), Gaps = 72/352 (20%)

Query: 522  CHGNGECV---SG-TCHCFPGFLGPDCSR--AAC---PVLCSGNGQYSKGR--CLCFSGW 570
            C   G C    SG  C C  G+ GP CS    AC   P L  G+   S G   C C    
Sbjct: 700  CAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSH 759

Query: 571  KGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCE---EADCIDPGCSNHG 623
             G +C   T  C+   C   G C+      SC C  G++G  CE      C D  C N  
Sbjct: 760  TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRA 819

Query: 624  VCIHG----ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGS---CTCDPNWTGPDC 676
             C        C C  G+ G +C+ L  +C  +     ++  ++G    C C   WTGP C
Sbjct: 820  TCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLC 879

Query: 677  SNEICSVD-------------CGSHGVCMGGT----CRCEEGWTGPACNQRA--CHPRCA 717
            +  + S               C + G+C+       C C  G+ G  C      C  R  
Sbjct: 880  NLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPC 939

Query: 718  EHG-TCKDGK----CECSQGWNGEHCT--IEGCPGL-CNSNGRCTLDQNGWHCVCQPGWR 769
            ++G TC        C+C+ G++G++C+  ++ C    C+++G CT    G+HC C PG+ 
Sbjct: 940  QNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFV 999

Query: 770  GAGCDVAMETLCTDSKDNEGDGLIDCMDPDC-----CLQSSCQNQPYCRGLP 816
            G  C              EGD + +C+D  C         S  N  YC+ LP
Sbjct: 1000 GLRC--------------EGD-VDECLDQPCHPTGTAACHSLANAFYCQCLP 1036



 Score =  121 bits (304), Expect = 8e-27
 Identities = 87/310 (28%), Positives = 119/310 (38%), Gaps = 53/310 (17%)

Query: 533 CHCFPGFLGPDCSR-----AACPVLCSGNGQYSKG--RCLCFSGWKGTECDVPTTQCIDP 585
           C C PGF G  C        + P    G  Q   G   C C  G++G  C     +C+  
Sbjct: 537 CICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSD 596

Query: 586 QC--GGRGICIMGS--CACNSGYKGESCEEADCIDPGCSNHGVC----IHGECHCSPGWG 637
            C  G   + + G+  C C SG+ G+ CE   C    C    +C        C C  G  
Sbjct: 597 PCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSP 656

Query: 638 GSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEI---CSVDCGSHGVC--- 691
           G           D C+ H  + Q S SC CD  WTGP+C  E+    S  C   G C   
Sbjct: 657 GC------APPEDNCTCHHGHCQRS-SCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQ 709

Query: 692 -MGGTCRCEEGWTGPACNQR--ACHP-RCAEHGTCKDGK----CECSQGWNGEHC--TIE 741
             G  C C  G+TGP C++   ACH   C   G+C        C C     G  C  + +
Sbjct: 710 PSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTD 769

Query: 742 GCPGL-CNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC 800
            C    C + G C      + C+C  G++G  C+  +   C DS               C
Sbjct: 770 YCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADS--------------PC 815

Query: 801 CLQSSCQNQP 810
             +++CQ+ P
Sbjct: 816 RNRATCQDSP 825



 Score =  121 bits (303), Expect = 1e-26
 Identities = 98/340 (28%), Positives = 124/340 (36%), Gaps = 67/340 (19%)

Query: 522 CHGNGECVSG----TCHCFPGFLGPDCSRAA--C----PVLCSGNG--QYSKG--RCLCF 567
           C   G C  G    TC C   + G DCS     C    P  C   G  Q S G   C+C 
Sbjct: 285 CQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCV 344

Query: 568 SGWKGTECDVPTTQCIDPQCGGRGICI----MGSCACNSGYKGESCEEAD-CIDPGCSNH 622
           SGW GT C+     CI   C     CI      SC C  G  G  C   D C+   C   
Sbjct: 345 SGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGD 404

Query: 623 GVCIHGE------CHCSPGWGGSNCE------ILKTMCPDQCSGHGTYLQESGS--CTCD 668
             C          C C PG+ G  C       ++    P  C   G+ L   GS  C C 
Sbjct: 405 AQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCP 464

Query: 669 PNWTGPDCS---NEICSVDCGSHGVCMGGT----CRCEEGWTGPAC----NQRACHPRCA 717
           P +TG  C    NE  S  C     C+       C C  G  G  C    N+ A  P C 
Sbjct: 465 PGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAP-CL 523

Query: 718 EHGTCKD----GKCECSQGWNGEHCT--IEGCPGL-CNSNGRCTLDQNGWHCVCQPGWRG 770
            H  C D     +C C  G++G  C   I+ C    C + G+C      +HC C PG+ G
Sbjct: 524 NHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEG 583

Query: 771 AGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQP 810
             C   ++               +C+   C + +SC + P
Sbjct: 584 PRCQTEVD---------------ECLSDPCPVGASCLDLP 608



 Score =  112 bits (279), Expect = 6e-24
 Identities = 98/375 (26%), Positives = 136/375 (36%), Gaps = 76/375 (20%)

Query: 518 CPRNCHGNGECVSGTCHCFPGFLGPDCSRAA--CPVLCSGNG---------QYSKGRCLC 566
           CP+    +    S  C C  G  GP C   A  CP     NG           +   CLC
Sbjct: 205 CPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLC 264

Query: 567 FSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESCEE--ADCI---DP 617
             G+ G +C+V    C+  QC   G C  G    +C C   + G  C E   +C     P
Sbjct: 265 PPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPP 324

Query: 618 GCSNHGVCIHG----ECHCSPGWGGSNC-EILKTMCPDQCSGHGTYLQESG--SCTCDPN 670
            C N G C +      C C  GWGG++C E L       C+   T +   G  SC C P 
Sbjct: 325 HCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPG 384

Query: 671 WTG------PDCSNEICSVD--CGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHG-- 720
            TG        C ++ C  D  C ++ +     C C+ G++GP C+Q       A+ G  
Sbjct: 385 RTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPS 444

Query: 721 TCKDG----------KCECSQGWNGEHCTIEGCPGL---CNSNGRCTLDQNGWHCVCQPG 767
            C+ G           C C  G+ G  C  +    L   C+    C      +HC+C PG
Sbjct: 445 PCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPG 504

Query: 768 WRGAGCDVAMETLCTDSKDNEGD-----------------------GLIDCMDPDCCLQS 804
             G  C+V      +    N  D                        + +C    C    
Sbjct: 505 LEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGG 564

Query: 805 SCQNQP---YCRGLP 816
            CQ+QP   +C+ LP
Sbjct: 565 QCQDQPGAFHCKCLP 579



 Score =  111 bits (278), Expect = 8e-24
 Identities = 114/374 (30%), Positives = 136/374 (36%), Gaps = 89/374 (23%)

Query: 518  CPRNCHGNGECVSGTCHCFPGFLGP-------DCSRAACPV------LCSGNGQYSKGR- 563
            CPRN H      S  C C  G+ GP        C +AA         LC   G       
Sbjct: 853  CPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGP 912

Query: 564  ---CLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGS----CACNSGYKGESC-EEAD-C 614
               C C  G++G+ C      C    C     C+       C C  GY G++C +E D C
Sbjct: 913  SYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDAC 972

Query: 615  IDPGCSNHGVCIHG----ECHCSPGWGGSNCEILKTMCPDQ-CSGHGTY----LQESGSC 665
                C NHG C        C C PG+ G  CE     C DQ C   GT     L  +  C
Sbjct: 973  QSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYC 1032

Query: 666  TCDPNWTGPDCSNEI--C-SVDCGSHGVC-------MGGTCRCEEGWTGPACNQRACHPR 715
             C P  TG  C  EI  C S  C   G C       +G  C C +G+ GP C+ RA  P 
Sbjct: 1033 QCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRA--PS 1090

Query: 716  CAEH-----GTC----KDG---KCECSQGWNGEHCTI----EGC--PGLCNSNGRCT--- 754
            C  H     G C    K G   +C C  G+ G  C      +GC  P  C  NG C+   
Sbjct: 1091 CGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETT 1150

Query: 755  -LDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLID--CMDP-------DCCLQS 804
             L   G+ C C     G  C       C   +   GDG  D  C  P       DC L  
Sbjct: 1151 GLGGPGFRCSCPHSSPGPRCQKPGAKGC---EGRSGDGACDAGCSGPGGNWDGGDCSL-- 1205

Query: 805  SCQNQPYCRGLPDP 818
                     G+PDP
Sbjct: 1206 ---------GVPDP 1210



 Score =  107 bits (268), Expect = 1e-22
 Identities = 90/324 (27%), Positives = 130/324 (40%), Gaps = 62/324 (19%)

Query: 533 CHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGI 592
           C C  G   P C+       C  +G   +  C+C  GW G EC+     CI   C   G 
Sbjct: 649 CLCPDG--SPGCAPPEDNCTCH-HGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGT 705

Query: 593 CIMG----SCACNSGYKGESCEEADCIDPGCSNHGVCIH-GECHCSPGWGGSNCEILKTM 647
           C       +C C +GY G +C E    +    + G C++ G C+ SPG            
Sbjct: 706 CYPQPSGYNCTCPTGYTGPTCSE----EMTACHSGPCLNGGSCNPSPG------------ 749

Query: 648 CPDQCSGHGTYLQESGSCTCDPNWTGPDC--SNEIC-SVDCGSHGVCMG--GT--CRCEE 700
                   G Y      CTC P+ TGP C  S + C S  C + G C+   GT  C C  
Sbjct: 750 --------GYY------CTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAM 795

Query: 701 GWTGPACNQRACHPRCAE-----HGTCKDG----KCECSQGWNGEHC--TIEGCPGL-CN 748
           G+ GP C  +   P CA+       TC+D     +C C  G+ G  C   ++ C    C 
Sbjct: 796 GFQGPRCEGK-LRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCP 854

Query: 749 SNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEG-DGLIDCMDPDCCLQSSCQ 807
            N  C      +HC+C  GW G  C++ + + C  +  ++G D    C +   C+ S   
Sbjct: 855 RNSHCLQTGPSFHCLCLQGWTGPLCNLPLSS-CQKAALSQGIDVSSLCHNGGLCVDSG-- 911

Query: 808 NQPYCRGLPDPQDIISQSLQSPSQ 831
              +C   P  Q  + Q   +P +
Sbjct: 912 PSYFCHCPPGFQGSLCQDHVNPCE 935



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 80/290 (27%), Positives = 103/290 (35%), Gaps = 72/290 (24%)

Query: 515  VVEC-PRNCHGNGECVSGT------CHCFPGFLGPDCSRA-----ACPVLCSGNGQYSKG 562
            V EC  + CH  G     +      C C PG  G  C        + P    G  + + G
Sbjct: 1007 VDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAG 1066

Query: 563  R-----CLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGS-------CACNSGYKGESCE 610
                  C C  G++G  C      C    C   G+C+          CAC SGY G    
Sbjct: 1067 SPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGP--- 1123

Query: 611  EADCIDP----GCSNHGVCIH-GECHCSPGWGGSNCEILKTMCPD-----QCSGHGTYLQ 660
              DC+ P    GC     C++ G C  + G GG      +  CP      +C   G    
Sbjct: 1124 --DCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPG---FRCSCPHSSPGPRCQKPGAKGC 1178

Query: 661  E--SGSCTCDP-------NWTGPDCSNEICSV--DCGSHGVCM----GGTC--RCE---- 699
            E  SG   CD        NW G DCS  +      C SH  C      G C  +C+    
Sbjct: 1179 EGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEEC 1238

Query: 700  --EGW---TGPACNQRACHPRCAEH---GTCKDGKCECSQGWNGEHCTIE 741
              +G+   T PAC   A    C +H   G C+ G      GW+G  C  E
Sbjct: 1239 LFDGYDCETPPACTP-AYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPE 1287


>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
           [Homo sapiens]
          Length = 737

 Score =  131 bits (329), Expect = 1e-29
 Identities = 96/340 (28%), Positives = 128/340 (37%), Gaps = 54/340 (15%)

Query: 493 LAFYNDGKNAEQVSFNTIVIESVVEC--------PRNCHGNGECVSG------TCHCFPG 538
           + F ND      V+    ++  V  C           C G G+C +       +C C   
Sbjct: 282 IGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQ 341

Query: 539 FLGPDCSRA-ACPVL-CSGNGQY---------SKGRCLCFSGWKGTECDVPTTQCIDPQC 587
           ++G  C    AC    C  N            S   C+C  G+ G  C      CI   C
Sbjct: 342 YVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPC 401

Query: 588 GGRGICIMG----SCACNSGYKGESCEEA--DCIDPGCSNHGVC----IHGECHCSPGWG 637
                CI      +C C  GY G +CEE    C    C N+G C    +H  C+CSPG+ 
Sbjct: 402 RNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFT 461

Query: 638 GSNCEILKTMCPDQCSGHGTY--LQESGSCTCDPNWTGPDCS---NEICSVDCGSHGVCM 692
           G  C  L   C      HGT   +  S  C CDP + G  C    NE  S  C +   C 
Sbjct: 462 GPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCR 521

Query: 693 ----GGTCRCEEGWTGPACN---QRACHPRCAEHGTCK----DGKCECSQGWNGEHCTI- 740
               G  C C   + G  C        +  C    TC     +G C C+ G+ GE C I 
Sbjct: 522 DLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDID 581

Query: 741 --EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAME 778
             E     C+  G C    NG++C C  GW GA C++ ++
Sbjct: 582 INECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQ 621



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 39/155 (25%), Positives = 62/155 (40%), Gaps = 26/155 (16%)

Query: 666 TCDPNWTGPDCSNEICSVDCGSHGVCMGG------TCRCEEGWTGPACNQR-ACHPR-CA 717
           TC P   G   +N++   +C   G C         +C CEE + G  C +  AC  + C 
Sbjct: 306 TCVP---GESHANDL---ECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQ 359

Query: 718 EHGTCKDGK---------CECSQGWNGEHCT--IEGCP-GLCNSNGRCTLDQNGWHCVCQ 765
            + +C D           C C  G+ GE C   I+ C    C +   C    +G+ C C 
Sbjct: 360 NNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCP 419

Query: 766 PGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC 800
            G+ G+ C+  ++   +    N G   +D +   C
Sbjct: 420 EGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTC 454



 Score = 40.0 bits (92), Expect = 0.031
 Identities = 33/121 (27%), Positives = 48/121 (39%), Gaps = 24/121 (19%)

Query: 673 GPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRA----CHPRCA-EHGTCKDGKC 727
           G   +N + +    + G C    CR      G  C  R      HP  A E G      C
Sbjct: 30  GSSLANPVPAAPLSAPGPCAAQPCR-----NGGVCTSRPEPDPQHPAPAGEPGY----SC 80

Query: 728 ECSQGWNGEHCTIEGCPGLCNSN----GRCTLDQN----GWHCVCQPGWRGAGCDVAMET 779
            C  G +G +C +   P  C SN    G C+   +    G+ C+C  G+ G  C+ A+ +
Sbjct: 81  TCPAGISGANCQLVADP--CASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPS 138

Query: 780 L 780
           L
Sbjct: 139 L 139



 Score = 40.0 bits (92), Expect = 0.031
 Identities = 25/92 (27%), Positives = 34/92 (36%), Gaps = 22/92 (23%)

Query: 614 CIDPGCSNHGVCIH------------GE----CHCSPGWGGSNCEILKTMCPDQCSGHGT 657
           C    C N GVC              GE    C C  G  G+NC+++   C      HG 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 658 YLQESGS------CTCDPNWTGPDCSNEICSV 683
               S S      C C+  + GP+C   + S+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSL 139



 Score = 37.7 bits (86), Expect = 0.15
 Identities = 19/57 (33%), Positives = 24/57 (42%), Gaps = 9/57 (15%)

Query: 564 CLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGS--------CACNSGYKGESCEEA 612
           C C +G  G  C +    C    C   G C   S        C CN GY+G +CE+A
Sbjct: 80  CTCPAGISGANCQLVADPCASNPCH-HGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135



 Score = 33.9 bits (76), Expect = 2.2
 Identities = 20/57 (35%), Positives = 25/57 (43%), Gaps = 13/57 (22%)

Query: 597 SCACNSGYKGESCEEADCIDPGCSN---HGVCIHGE--------CHCSPGWGGSNCE 642
           SC C +G  G +C+     DP  SN   HG C            C C+ G+ G NCE
Sbjct: 79  SCTCPAGISGANCQLV--ADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  125 bits (314), Expect = 6e-28
 Identities = 92/320 (28%), Positives = 121/320 (37%), Gaps = 92/320 (28%)

Query: 519  PRNC---HGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNG-------------QYSKG 562
            P NC   HG+ + +SG C C  G++GP C +  CP    G G              +  G
Sbjct: 872  PCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQ-CPQGHFGPGCEQRCQCQHGAACDHVSG 930

Query: 563  RCLCFSGWKGTECD---------VPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEE-- 611
             C C +GW+GT C+         +      +   G     + GSC C +G +G  C E  
Sbjct: 931  ACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETC 990

Query: 612  -ADCIDPGCSNHGVC--------IHGECHCSPGWGGSNCEILKTMCP-----DQCSGHGT 657
             A      CS    C        +HG+CHC+PGW G +C      CP     D C  H  
Sbjct: 991  PAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSC---LQACPAGLYGDNCR-HSC 1046

Query: 658  YLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPR-- 715
              Q  G  TCDP                      + G C C EGW G AC ++ C PR  
Sbjct: 1047 LCQNGG--TCDP----------------------VSGHCACPEGWAGLAC-EKECLPRDV 1081

Query: 716  ---CAEHGTCKD--------GKCECSQGWNGEHCTI--------EGCPGLCNSNGRCTLD 756
               C   G C +        G+C C  GW G+ C          E C   C+        
Sbjct: 1082 RAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACH 1141

Query: 757  QNGWHCVCQPGWRGAGCDVA 776
                 C C PG+ G+GC+ A
Sbjct: 1142 HVTGACRCPPGFTGSGCEQA 1161



 Score =  113 bits (282), Expect = 3e-24
 Identities = 89/334 (26%), Positives = 117/334 (35%), Gaps = 87/334 (26%)

Query: 522  CHGNGEC--VSGTCHCFPGFLGPDCSRAACP------------VLCSGNGQYSKGRCLCF 567
            C   G C  VSG C C  G+ G  C +   P             L  G      GRCLC 
Sbjct: 1048 CQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCP 1107

Query: 568  SGWKGTECDVPTTQ-CIDPQCGGRGIC--------IMGSCACNSGYKGESCEEA------ 612
            +GW G +C  P  +      C  R  C        + G+C C  G+ G  CE+A      
Sbjct: 1108 AGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSF 1167

Query: 613  --DCIDP-GCSNHGVCIH---GECHCSPGWGGSNCEILKTMCPDQ-----------CSGH 655
              DC     C       H   G C C+ G+ G +C+     CP             C   
Sbjct: 1168 GEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQ---QRCPPGRYGPGCEQLCGCLNG 1224

Query: 656  GTYLQESGSCTCDPNWTGPDCS------------NEICSVDCGSHGVC--MGGTCRCEEG 701
            G+    +G+C C   + G DC+              +C   CG    C  + GTC C  G
Sbjct: 1225 GSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCG--CGQGAACDPVTGTCLCPPG 1282

Query: 702  WTGPACNQRACHPR-----------CAEHGTC--KDGKCECSQGWNGEHCTIEGCPGL-- 746
              G  C +R C              C   G C   +G C C  GW G HC +   PG   
Sbjct: 1283 RAGVRC-ERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYG 1341

Query: 747  ------CNSNGRCTLDQNGWHCVCQPGWRGAGCD 774
                  C+ +   T +     C C PG+ G  C+
Sbjct: 1342 AACHLECSCHNNSTCEPATGTCRCGPGFYGQACE 1375



 Score =  112 bits (281), Expect = 4e-24
 Identities = 93/336 (27%), Positives = 121/336 (36%), Gaps = 87/336 (25%)

Query: 521  NCHGNGEC--VSGTCHCFPGFLGPDCSRAA--------CPVLCSGNGQY-----SKGRCL 565
            +C     C  V+G C C PGF G  C +A         C  +C   G+      + G C 
Sbjct: 1133 SCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCS 1192

Query: 566  CFSGWKGTECDVPTTQC----IDPQC--------GGRGICIMGSCACNSGYKGESCEEA- 612
            C +G+ G  C     +C      P C        GG      G+C C +G+ G  C    
Sbjct: 1193 CAAGYHGPSCQ---QRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTC 1249

Query: 613  -------DCIDP-GCSNHGVC--IHGECHCSPGWGGSNCEILKTMCPDQ----------- 651
                   +C    GC     C  + G C C PG  G  CE     CP             
Sbjct: 1250 PQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCE---RGCPQNRFGVGCEHTCS 1306

Query: 652  CSGHGTYLQESGSCTCDPNWTGPDCS--------NEICSVDCGSHG--VC--MGGTCRCE 699
            C   G     +GSC+C   WTG  C            C ++C  H    C    GTCRC 
Sbjct: 1307 CRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCG 1366

Query: 700  EGWTGPACNQ--------RACHPRC-AEHGTCKD---GKCECSQGWNGEHCTI------- 740
             G+ G AC            C   C  +HG   D   G+C C  G++G  C         
Sbjct: 1367 PGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSF 1426

Query: 741  -EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDV 775
             EGC   C+ +G    D     C+C PG  GA C++
Sbjct: 1427 GEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNL 1462



 Score =  102 bits (255), Expect = 4e-21
 Identities = 89/317 (28%), Positives = 114/317 (35%), Gaps = 81/317 (25%)

Query: 521 NCHGNGEC--VSGTCHCFPGFLGPDCSRAACP-----------VLCSGNGQYSK--GRCL 565
           +C   G C  V+G C C PG  G +C    CP             C+  G+  +  G CL
Sbjct: 569 SCQNGGTCDSVTGACRCPPGVSGTNCEDG-CPKGYYGKHCRKKCNCANRGRCHRLYGACL 627

Query: 566 CFSGWKGTECDVPTTQ-CIDPQCGGRGICIM----------GSCACNSGYKGESCEEADC 614
           C  G  G  C +        P C     C+           GSC+C +G++GE C+ A+C
Sbjct: 628 CDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQ-AEC 686

Query: 615 ----IDPGCSNHGVC--------IHGEC--HCSPGWGGSNCE------ILKTMCPDQCSG 654
                 PGC     C        + GEC   C  G+ G +C            C   CS 
Sbjct: 687 ELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC 746

Query: 655 HGTYLQE-SGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACH 713
            G      +G C C P  TG DC  +                  C EG  G  C Q  C 
Sbjct: 747 GGAPCHGVTGQCRCPPGRTGEDCEAD------------------CPEGRWGLGC-QEIC- 786

Query: 714 PRCAEHGTC--KDGKCECSQGWNGEHCTIEGCPG-----LCNSNGRCTLDQN----GWHC 762
           P C     C  + G C C  G+ G  C  + CP       C +   C  D +      HC
Sbjct: 787 PACQHAARCDPETGACLCLPGFVGSRCQ-DVCPAGWYGPSCQTRCSCANDGHCHPATGHC 845

Query: 763 VCQPGWRGAGCDVAMET 779
            C PGW G  C  A +T
Sbjct: 846 SCAPGWTGFSCQRACDT 862



 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 75/271 (27%), Positives = 96/271 (35%), Gaps = 71/271 (26%)

Query: 565 LCFSGWKGTECDVPTTQCIDPQCGGRGICIMG--SCACNSGYKGESCEEA--------DC 614
           +C     G +C +    C D  C   G C++G   C C  G+ G  C E         +C
Sbjct: 510 VCLDDSFGHDCSLT---CDD--CRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNC 564

Query: 615 -IDPGCSNHGVC--IHGECHCSPGWGGSNCEILKTMCPD-----------QCSGHGTYLQ 660
                C N G C  + G C C PG  G+NCE     CP             C+  G   +
Sbjct: 565 SFSCSCQNGGTCDSVTGACRCPPGVSGTNCE---DGCPKGYYGKHCRKKCNCANRGRCHR 621

Query: 661 ESGSCTCDPN------------WT-GPDCSNEICSVDCGSHGV-CMGGTCRCEEGWTGPA 706
             G+C CDP             W  GP CS E   V   +       G+C C+ G+ G  
Sbjct: 622 LYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGER 681

Query: 707 CNQRACH-----PRCAEHGTCK--------DGKC--ECSQGWNGEHCTIE--------GC 743
           C Q  C      P C +  TC          G+C   C  G+ GE C  E         C
Sbjct: 682 C-QAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNC 740

Query: 744 PGLCNSNGRCTLDQNGWHCVCQPGWRGAGCD 774
              C+  G       G  C C PG  G  C+
Sbjct: 741 SSSCSCGGAPCHGVTG-QCRCPPGRTGEDCE 770



 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 66/233 (28%), Positives = 88/233 (37%), Gaps = 52/233 (22%)

Query: 529  VSGTCHCFPGFLGPDCSRAA--------CPVLCS----GNGQYSKGRCLCFSGWKGTECD 576
            V+GTC C PG  G  C R          C   CS    G    S G C C  GW G  C+
Sbjct: 1273 VTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCE 1332

Query: 577  VPT------TQC-IDPQCGGRGIC--IMGSCACNSGYKGESCEE--------ADCIDPGC 619
            +          C ++  C     C    G+C C  G+ G++CE         A C     
Sbjct: 1333 LACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCW 1392

Query: 620  SNHGV-C--IHGECHCSPGWGGSNCE------ILKTMCPDQCSGHGTYLQE--SGSCTCD 668
              HG  C  I G C C  G+ G  CE           C  +C   G    +  +G C C 
Sbjct: 1393 CQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCP 1452

Query: 669  PNWTGPDCSNEI--------CSV--DCGSHGVC--MGGTCRCEEGWTGPACNQ 709
            P  +G  C+ +         C++  DCG    C  + G C C +G+ GP C +
Sbjct: 1453 PGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCRE 1505



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 92/374 (24%), Positives = 123/374 (32%), Gaps = 118/374 (31%)

Query: 510 IVIESVVECPRNCHGNGECVSGTCHCFPGFLGP------------------DCSRA-ACP 550
           I +E V  C  N   NG C  G  H   G L                    DC+ +  C 
Sbjct: 327 IEMEIVNSCEAN---NGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQ 383

Query: 551 VLCSGN-GQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGIC------IMGS--CACN 601
            +C+ N G Y    C C++G++    D    + +D     RG C      + GS  C+C 
Sbjct: 384 QVCTNNPGGYE---CGCYAGYR-LSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCE 439

Query: 602 SGYK------GESCEEADCID-----------------------------PGCSNHGVCI 626
           +GY+      G S  E   +D                              G       +
Sbjct: 440 AGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAEL 499

Query: 627 HGECH------CSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEI 680
            GE        C     G +C +    C D C   GT L     C C   WTG  C NE 
Sbjct: 500 RGEHTLTEKFVCLDDSFGHDCSLT---C-DDCRNGGTCLLGLDGCDCPEGWTGLIC-NET 554

Query: 681 C-----------SVDCGSHGVC--MGGTCRCEEGWTGPACNQ--------RACHPR--CA 717
           C           S  C + G C  + G CRC  G +G  C          + C  +  CA
Sbjct: 555 CPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCA 614

Query: 718 EHGTCKD--GKCECSQGWNGEHCTIEGCPGL-----CNSNGRC------TLDQNGWHCVC 764
             G C    G C C  G  G  C +  CP       C+   +C      + D+    C C
Sbjct: 615 NRGRCHRLYGACLCDPGLYGRFCHLT-CPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSC 673

Query: 765 QPGWRGAGCDVAME 778
           + G+RG  C    E
Sbjct: 674 KAGFRGERCQAECE 687



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 80/325 (24%), Positives = 110/325 (33%), Gaps = 80/325 (24%)

Query: 517 ECPRN-CHGNGECVSGT---CHCFPGFLGPDCS---------RAACPVLCSGN-GQYSKG 562
           EC  + C   G CV G+   CHC PGF GP C             C   C    G Y   
Sbjct: 127 ECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSY--- 183

Query: 563 RCLCFSGWKGTECDVPTTQCIDPQCGGRGIC---------IMGSCACNSGYKGESCEEAD 613
            C C  G++    D  T   I+    G G C             C C  G++ +  +   
Sbjct: 184 LCECKPGFR-LHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQE-DGRH 241

Query: 614 CI--DPGCSNHGVCIH--------GECHCSPGW----GGSNCEILKTMCPD--QCSGHGT 657
           C+   P  + +G C+H          C C  G+     G  CE +        QC+    
Sbjct: 242 CVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCL 301

Query: 658 YLQESGSCTCDPNW----TGPDC---SNEICSVDCGSHGVCMGGTCRCEEGWTGPAC--- 707
             Q S  C C   +     G  C     EI +    ++G C  G   C     GP C   
Sbjct: 302 NTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG---CSHTSAGPLCTCP 358

Query: 708 -------NQRAC--------HPRCAEHGTCKDG--KCECSQGW--NGEHCTIEGCPGLCN 748
                  +QR C         P C +  T   G  +C C  G+  + + C  E      +
Sbjct: 359 RGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECAS 418

Query: 749 SNG----RCTLDQNGWHCVCQPGWR 769
           S G     CT     + C C+ G+R
Sbjct: 419 SRGGCEHHCTNLAGSFQCSCEAGYR 443



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 68/277 (24%), Positives = 96/277 (34%), Gaps = 80/277 (28%)

Query: 607 ESCEEADCIDPGCSNHGVCIHGE---CHCSPGWGGSNCEILKTMCPDQCSGHGTYLQE-- 661
           E C  A+C    C + G C+ G    CHC PG+ G  C+       D+C  H    Q   
Sbjct: 121 EGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQ----YDVDECRTHNGGCQHRC 176

Query: 662 -----SGSCTCDPNWTGPDCSNEICSVD--------CGSHGVCMGGT---CRCEEGW--- 702
                S  C C P +     S    +++        C  H V +  T   C+C  G+   
Sbjct: 177 VNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQ 236

Query: 703 -TGPACNQRACHPRCAEHGTCKD--------GKCECSQGW----NGEHC-TIEGC-PGLC 747
             G  C +R+  P    +G+C           +CEC  G+    +G+ C  ++ C  GL 
Sbjct: 237 EDGRHCVRRS--PCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLA 294

Query: 748 NSNGRCTLDQNGWHCVCQPGW----------------------RGAGCD-----VAMETL 780
                C   Q  + CVC  G+                         GC       +   L
Sbjct: 295 QCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPL 354

Query: 781 CTDSKDNEGD-------GLIDCMDPDCCLQSSCQNQP 810
           CT  +  E D        + DC D  CC Q  C N P
Sbjct: 355 CTCPRGYELDTDQRTCIDVDDCADSPCC-QQVCTNNP 390


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  122 bits (307), Expect = 4e-27
 Identities = 94/337 (27%), Positives = 129/337 (38%), Gaps = 64/337 (18%)

Query: 521  NCHGNGECVSGT----CHCFPGFLGPDCS---RAACPVLCSGNGQY----SKGRCLCFSG 569
            +C   G+C        C C PGF G  C           C  NG      ++  C C   
Sbjct: 898  SCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPE 957

Query: 570  WKGTECDVPTTQCIDPQCGGRGICIMGS----CACNSGYKGESCEEA--DCIDPGCSNHG 623
            + G  C++   +C    C     C+  +    C C  GY G +CE    +C+   C + G
Sbjct: 958  YHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDG 1017

Query: 624  VCIHG----ECHCSPGWGGSNCEILKTMCPDQCSGHG--TYLQESGSCTCDPNWTGPDCS 677
            VCI G     C C  G+ G++CE     C      HG  T L     C+CD + T   C 
Sbjct: 1018 VCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCK 1077

Query: 678  ---NEICSVDCGSHGVCM----GGTCRCEEGWTGPACNQ---RACHPR-----CAEHGTC 722
               N+  S+ C + G C     G TC C  G+TG  C +       P      C   G C
Sbjct: 1078 IKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGIC 1137

Query: 723  KDGK-----CECSQGWNGEHCTI---EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCD 774
             DG      C C  G++G+ C I   E     C     C    NG+ C CQPGW G  C+
Sbjct: 1138 VDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197

Query: 775  VAMETLCTDSKDNEGDGLIDCMDPDCCLQSSC-QNQP 810
              +E +                 P+ C+   C +N+P
Sbjct: 1198 NELECI-----------------PNSCVHELCMENEP 1217



 Score =  120 bits (301), Expect = 2e-26
 Identities = 88/322 (27%), Positives = 131/322 (40%), Gaps = 56/322 (17%)

Query: 543 DCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMG------ 596
           DC  A+C    +           C  G+KGT+C++   +C    C     CI        
Sbjct: 646 DCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFC 705

Query: 597 ------------SCACNSGYKGESCEE--ADCIDPGCSNHGVC----IHGECHCSPGWGG 638
                       SC CN GY G  CE+   DCI   C ++  C    +  +C C   W G
Sbjct: 706 QCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEG 765

Query: 639 SNCEILKTMCP-DQCSGHGTY--LQESGSCTCDPNWTGPDCSNEICSVD---CGSHGVCM 692
           + CE     C  + C  + T   L +S  C C   WTG +CS EI   D   C + G+C 
Sbjct: 766 NFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCH 825

Query: 693 GGT------CRCEEGWTGPACNQR-----ACHPRCAEHGTC-----KDGKCECSQGWNGE 736
             T      C C   +TG  C+QR       H  C  + TC      +  C C + + G+
Sbjct: 826 ESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGK 885

Query: 737 HCTIE--GCPGL-CNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLI 793
           +C I+   C  L C   G C    N + C+C+PG+ G+ C++ +    ++   N G    
Sbjct: 886 NCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNG---- 941

Query: 794 DCMDPDCCLQSSCQNQ---PYC 812
            C+D       +C+ +   P+C
Sbjct: 942 TCVDLTNRFFCNCEPEYHGPFC 963



 Score =  107 bits (268), Expect = 1e-22
 Identities = 75/301 (24%), Positives = 125/301 (41%), Gaps = 44/301 (14%)

Query: 532  TCHCFPGFLG-------PDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCID 584
            +C C PG++G        DC   AC    +    +   +C+C S W+G  C+  + +C  
Sbjct: 718  SCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKM 777

Query: 585  PQCGGRGICI----MGSCACNSGYKGESCEEA--DCIDPGCSNHGVC----IHGE--CHC 632
              C     C        C C SG+ G++C E   +C    C N G+C    I G+  C C
Sbjct: 778  NPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLC 837

Query: 633  SPGWGGSNCEILKTMCP---DQCSGHGTYL---QESGSCTCDPNWTGPDCSNEI---CSV 683
             P + G  C     +C    + C  + T L     +  C C   + G +C  ++     +
Sbjct: 838  PPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFL 897

Query: 684  DCGSHGVC----MGGTCRCEEGWTGPAC----NQRACHPRCAEHGTCKDGK----CECSQ 731
             C  +G C        C C  G++G  C    N+ +  P C  +GTC D      C C  
Sbjct: 898  SCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEP-CKNNGTCVDLTNRFFCNCEP 956

Query: 732  GWNGEHCTIE--GCP-GLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNE 788
             ++G  C ++   C    C     C    +G++C+C PG+ G  C++ ++   ++   ++
Sbjct: 957  EYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHD 1016

Query: 789  G 789
            G
Sbjct: 1017 G 1017



 Score =  105 bits (262), Expect = 6e-22
 Identities = 95/377 (25%), Positives = 134/377 (35%), Gaps = 94/377 (24%)

Query: 513  ESVVECPRN-CHGNGEC----VSGTCHCFPGFLGPDCSRAA--CPVL-CSGNGQ----YS 560
            + + +C  N C  N  C    +S  C C   + G  C + +  C +  C  N      Y 
Sbjct: 732  QDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYK 791

Query: 561  KGRCLCFSGWKGTECDVPTTQCIDPQCGGRGIC----IMGS------------------- 597
              RC C SGW G  C     +C    C   G+C    I G                    
Sbjct: 792  SYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYN 851

Query: 598  ------------------------CACNSGYKGESCE--EADCIDPGCSNHGVC----IH 627
                                    C C   ++G++CE    DC+   C ++G C     +
Sbjct: 852  LCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNN 911

Query: 628  GECHCSPGWGGSNCEILKTMCPDQ-CSGHGTYLQESGS--CTCDPNWTGPDCSNEI--CS 682
              C C PG+ GS CEI    C  + C  +GT +  +    C C+P + GP C  ++  C 
Sbjct: 912  FRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCK 971

Query: 683  VD-CGSHGVCM----GGTCRCEEGWTGPACN---QRACHPRCAEHGTCKDG----KCECS 730
            +  C     C+    G  C C  G+TG  C           C   G C DG     C+C 
Sbjct: 972  ISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCK 1031

Query: 731  QGWNGEHCTIEGCPGLCNS--NGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNE 788
             G+ G HC       L N   +GRCT   N + C C        C + +   CT      
Sbjct: 1032 SGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKIND-CTS----- 1085

Query: 789  GDGLIDCMDPDCCLQSS 805
                I CM+   C +S+
Sbjct: 1086 ----IPCMNEGFCQKSA 1098



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 77/307 (25%), Positives = 106/307 (34%), Gaps = 59/307 (19%)

Query: 553 CSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGIC----IMGSCACNSGYKGES 608
           C       + R LCF  W G      TT   + +C    +C        C+C+  Y G  
Sbjct: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRL 600

Query: 609 CEEADCIDPGCSNHGVCIHG-------ECHCS--PGWGGSNCEILKTMCPDQCSGHG--- 656
           C     +D    NH + +HG        C+CS    +  + CEI    C      +G   
Sbjct: 601 C--VVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTS 658

Query: 657 TYLQESGSCTCDPNWTGPDCS---NEICSVDCGSHGVCM------------------GGT 695
           T+L+      C P + G  C    +E  S  C +   C+                  G +
Sbjct: 659 THLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFS 718

Query: 696 CRCEEGWTGPACNQRA--CHPRCAEH-GTCKD----GKCECSQGWNGEHCTIEG--CP-G 745
           C C  G+ G  C Q    C     EH  TCKD     +C C   W G  C  E   C   
Sbjct: 719 CLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMN 778

Query: 746 LCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSS 805
            C +N  CT     + C C  GW G  C   +    +D           CM+   C +S+
Sbjct: 779 PCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSD----------PCMNGGLCHEST 828

Query: 806 CQNQPYC 812
              Q  C
Sbjct: 829 IPGQFVC 835



 Score = 69.3 bits (168), Expect = 5e-11
 Identities = 64/237 (27%), Positives = 89/237 (37%), Gaps = 37/237 (15%)

Query: 577 VPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHG------EC 630
           V T   I     G   C +G    N   K + C+E+      CS HG C+         C
Sbjct: 143 VGTHYFITVMASGPSPCPLG-LRLNVTVKQQFCQES-LSSEFCSGHGKCLSEAWSKTYSC 200

Query: 631 HCSPGWGGSNCEILKTMCPDQCSGHGTYL-------QESGSCTCDPNWTGPDCSNEI--C 681
           HC P + G  C+ L       C  +G+ +       +++  C C P +TG +CS  I  C
Sbjct: 201 HCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQC 260

Query: 682 SVDCGSHGVCMGGT-----CRCEEGWTGPACNQRACHPRCAEHGTCKDGKC--------- 727
                 HG C   T     C C+E ++GP C   A    C      K G C         
Sbjct: 261 QPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSA--KPCVSLLFWKRGICPNSSSAYTY 318

Query: 728 ECSQG---WNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLC 781
           EC +G    NGE    E     C +   C    N   C+C P +    C  +++T C
Sbjct: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK-SIQTSC 374



 Score = 68.9 bits (167), Expect = 6e-11
 Identities = 59/233 (25%), Positives = 81/233 (34%), Gaps = 69/233 (29%)

Query: 522  CHGNGECVSG----TCHCFPGFLGPDCSRAA-------------------CPVLCSGNGQ 558
            C  +G C+ G    TC C  GF G  C   A                    P  C  +G 
Sbjct: 1013 CLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGT 1072

Query: 559  YSKGR-------------------------CLCFSGWKGTECDVPTTQCIDPQ-----CG 588
             ++ +                         C+C  G+ G  C+     C +P+     C 
Sbjct: 1073 STQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICL 1132

Query: 589  GRGICIMG-----SCACNSGYKGESCEEA--DCIDPGCSNHGVC---IHGE-CHCSPGWG 637
              GIC+ G      C C  G+ G+ CE    +C    C +   C   I+G  C C PGW 
Sbjct: 1133 NGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWS 1192

Query: 638  GSNCEILKTMCPDQCSGHGTYLQESGS-CTCDPNW----TGPDCSNEICSVDC 685
            G +CE      P+ C        E GS C C P +     G  C +EI  + C
Sbjct: 1193 GHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITC 1245



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 59/232 (25%), Positives = 83/232 (35%), Gaps = 44/232 (18%)

Query: 587 CGGRGICIMG------SCACNSGYKGESCEEAD-CIDPGCSNHGVCIHG---------EC 630
           C G G C+        SC C   + G+ C+E D C    C N+G CI+          EC
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242

Query: 631 HCSPGWGGSNCEILKTMCPDQCSGHGT---YLQESGSCTCDPNWTGPDCSNEICSVDCGS 687
            C P + G NC  +   C      HG        S  C CD  ++GP C  E+ +  C S
Sbjct: 243 VCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFC--EVSAKPCVS 300

Query: 688 -----HGVCMGG----TCRCEEGWT---GPACNQRACHPRCAEHGTC----KDGKCECSQ 731
                 G+C       T  C +G +   G           C     C     D  C CS 
Sbjct: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360

Query: 732 GWNGEHC-----TIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAME 778
            +    C     + E  P    +N  C   +  + C C  G+    C+ A++
Sbjct: 361 IFTDLLCKSIQTSCESFP--LRNNATCKKCEKDYPCSCISGFTEKNCEKAID 410



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 67/279 (24%), Positives = 101/279 (36%), Gaps = 52/279 (18%)

Query: 522 CHGNGECVSGT---------CHCFPGFLGPDCSR--AAC-PVLC----SGNGQYSKGRCL 565
           C  NG C++           C C P F G +CS     C P +C      N   +   C 
Sbjct: 222 CKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICE 281

Query: 566 CFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCAC-------NSGYKGESCEEADCIDPG 618
           C   + G  C+V    C+      RGIC   S A        +S   GE+      + P 
Sbjct: 282 CDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVP- 340

Query: 619 CSNHGVCIHGE----CHCSPGWGGSNCEILKTMC---PDQCSGHGTYLQESGSCTCDPNW 671
           C N   CI       C CSP +    C+ ++T C   P + +      ++   C+C   +
Sbjct: 341 CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF 400

Query: 672 TGPDCSN-----EICSVDCGSHGVCMGGTCR----CEEGWTGPAC---------NQRACH 713
           T  +C       ++ S++C +   C     R    C  G T   C         +Q  C+
Sbjct: 401 TEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCY 460

Query: 714 PRCAEHGTCKD-GKCECSQGWNGEHCTIEG--CPGLCNS 749
                HG C+D G  +    W       EG  C G+ ++
Sbjct: 461 CGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDA 499



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 73/291 (25%), Positives = 100/291 (34%), Gaps = 79/291 (27%)

Query: 522 CHGNGECVSG------TCHCFPGFLGPDCSRA-ACPVL-CSGNGQYSKGRCLCFSGWKGT 573
           C G+G+C+S       +CHC P F G  C    AC    C  NG     R      W   
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR----ENW--- 235

Query: 574 ECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGE---- 629
                     D Q           C C+  + G++C E   I   C  H VC HG     
Sbjct: 236 ----------DEQA--------YECVCHPPFTGKNCSE---IIGQCQPH-VCFHGNCSNI 273

Query: 630 ------CHCSPGWGGSNCEI-----------LKTMCPDQCSGHGTYLQESGSCTCDPNWT 672
                 C C   + G  CE+            + +CP+  S + TY    GS     +  
Sbjct: 274 TSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAY-TYECPKGS----SSQN 328

Query: 673 GPDCSNEICSVDCGSHGVCM----GGTCRCEEGWTGPACN--QRACHP-RCAEHGTC--- 722
           G    +E   V C +   C+       C C   +T   C   Q +C       + TC   
Sbjct: 329 GETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKC 388

Query: 723 -KDGKCECSQGWNGEHC--TIEGCPGL---CNSNGRCTLDQNGWHCVCQPG 767
            KD  C C  G+  ++C   I+ C  L   C +   C      +  VC PG
Sbjct: 389 EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 26/95 (27%), Positives = 37/95 (38%), Gaps = 13/95 (13%)

Query: 707  CNQRACH-PRCAEHGTCKDGK----CECSQGWNGEHCT--IEGC------PGLCNSNGRC 753
            C+   C   +C   GTC +      C C+ GW G  CT  +  C      P  C+    C
Sbjct: 2609 CHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATC 2668

Query: 754  TLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNE 788
                +G+ C C  G  G  C+ A+       + NE
Sbjct: 2669 ISLPHGYTCFCPLGTTGIYCEQALSISDPSFRSNE 2703



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 28/96 (29%), Positives = 37/96 (38%), Gaps = 26/96 (27%)

Query: 628  GECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGS--CTCDPNWTGPDCSNEICSVD- 684
            G+CH SP      C ++K      C   GT ++   S  C C   W G  C+  + + D 
Sbjct: 2607 GQCHASP------CSLMK------CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDP 2654

Query: 685  -------CGSHGVCM----GGTCRCEEGWTGPACNQ 709
                   C     C+    G TC C  G TG  C Q
Sbjct: 2655 EHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 39.7 bits (91), Expect = 0.041
 Identities = 28/103 (27%), Positives = 39/103 (37%), Gaps = 13/103 (12%)

Query: 677  SNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHP--RCAEHGTCKDGKCECSQGWN 734
            + E+   + G+ G    G C       G AC    C     C  +GT     C C   W 
Sbjct: 2855 NQELQLTEFGAKGGSNVGDC------DGTACGYNTCRNGGECTVNGTTFS--CRCLPDWA 2906

Query: 735  GEHC--TIEGCPGLCNSNGRCTLDQN-GWHCVCQPGWRGAGCD 774
            G  C  ++     LC     C  DQ+  + C+C  GW G  C+
Sbjct: 2907 GNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949



 Score = 39.7 bits (91), Expect = 0.041
 Identities = 26/88 (29%), Positives = 35/88 (39%), Gaps = 11/88 (12%)

Query: 603  GYKGES----CEEADCIDPGCSNHGVC-IHG---ECHCSPGWGGSNCEILKTMCPDQCSG 654
            G KG S    C+   C    C N G C ++G    C C P W G+ C    +   + C  
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLH 2923

Query: 655  HGTYLQE---SGSCTCDPNWTGPDCSNE 679
                + +   S SC C   W G  C N+
Sbjct: 2924 QSLCIPDQSFSYSCLCTLGWVGRYCENK 2951



 Score = 39.7 bits (91), Expect = 0.041
 Identities = 24/76 (31%), Positives = 31/76 (40%), Gaps = 12/76 (15%)

Query: 675  DCSNEICSVD-CGSHGVC-MGGT---CRCEEGWTGPACNQ--RACHPRCAEHGTCKDGK- 726
            DC    C  + C + G C + GT   CRC   W G  CNQ     +  C     C   + 
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQS 2932

Query: 727  ----CECSQGWNGEHC 738
                C C+ GW G +C
Sbjct: 2933 FSYSCLCTLGWVGRYC 2948



 Score = 38.1 bits (87), Expect = 0.12
 Identities = 31/100 (31%), Positives = 39/100 (39%), Gaps = 17/100 (17%)

Query: 523  HGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQC 582
            H N     G CH  P  L    +   C  + SG   Y    C C +GWKG+ C    + C
Sbjct: 2599 HPNAGRSVGQCHASPCSLMKCGNGGTC--IESGTSVY----CNCTTGWKGSFCTETVSTC 2652

Query: 583  IDPQ------CGGRGICIM----GSCACNSGYKGESCEEA 612
             DP+      C     CI      +C C  G  G  CE+A
Sbjct: 2653 -DPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQA 2691



 Score = 37.7 bits (86), Expect = 0.15
 Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 13/71 (18%)

Query: 522  CHGNGEC-VSGT---CHCFPGFLGPDCSRAACPV--------LCSGNGQYSKGRCLCFSG 569
            C   GEC V+GT   C C P + G  C+++   +        LC  +  +S   CLC  G
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYS-CLCTLG 2942

Query: 570  WKGTECDVPTT 580
            W G  C+  T+
Sbjct: 2943 WVGRYCENKTS 2953



 Score = 37.4 bits (85), Expect = 0.20
 Identities = 22/78 (28%), Positives = 31/78 (39%), Gaps = 11/78 (14%)

Query: 543  DCSRAACPV-LCSGNGQYSKG----RCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMG- 596
            DC   AC    C   G+ +       C C   W G  C+  +  C++  C  + +CI   
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCN-QSVSCLNNLCLHQSLCIPDQ 2931

Query: 597  ----SCACNSGYKGESCE 610
                SC C  G+ G  CE
Sbjct: 2932 SFSYSCLCTLGWVGRYCE 2949



 Score = 36.6 bits (83), Expect = 0.34
 Identities = 23/76 (30%), Positives = 28/76 (36%), Gaps = 11/76 (14%)

Query: 575  CDVPTTQCIDPQCGGRGICIMGS----CACNSGYKGESCEEADCIDPGCSNHGVCIHGE- 629
            C VP   C    C   G CI  +    C C   Y G+ C+ A C +  C N   C+    
Sbjct: 2334 CHVPW--CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSG 2391

Query: 630  ----CHCSPGWGGSNC 641
                C C  G  G  C
Sbjct: 2392 TDIVCLCPYGRSGPLC 2407



 Score = 36.2 bits (82), Expect = 0.45
 Identities = 18/67 (26%), Positives = 30/67 (44%), Gaps = 11/67 (16%)

Query: 651  QCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVD--CGSHGVCM-----GGTCRCEEGWT 703
            +C+ +GT      SC C P+W G  C+  +  ++  C    +C+       +C C  GW 
Sbjct: 2889 ECTVNGTTF----SCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWV 2944

Query: 704  GPACNQR 710
            G  C  +
Sbjct: 2945 GRYCENK 2951



 Score = 35.4 bits (80), Expect = 0.77
 Identities = 24/82 (29%), Positives = 36/82 (43%), Gaps = 10/82 (12%)

Query: 607  ESCEEADCIDPGCSNHGVCIHGE----CHCSPGWGGSNCEILKTMCPDQCSGHG-TYLQE 661
            E+C    C    C N+G CI       C C   + G  C+     C +   G+G T + +
Sbjct: 2332 ENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF--ASCENNPCGNGATCVPK 2389

Query: 662  SGS---CTCDPNWTGPDCSNEI 680
            SG+   C C    +GP C++ I
Sbjct: 2390 SGTDIVCLCPYGRSGPLCTDAI 2411



 Score = 35.0 bits (79), Expect = 1.0
 Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 16/87 (18%)

Query: 708  NQRACH-PRCAEH-----GTCKDGK----CECSQGWNGEHCTIEGCPGLCNSNGRCTLDQ 757
            N   CH P CA H     GTC        CEC + ++G+ C    C      NG   + +
Sbjct: 2330 NIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPK 2389

Query: 758  NGWHCVCQPGWRGAGCDVAMETLCTDS 784
            +G   VC   +  +G       LCTD+
Sbjct: 2390 SGTDIVCLCPYGRSG------PLCTDA 2410



 Score = 32.3 bits (72), Expect = 6.5
 Identities = 11/34 (32%), Positives = 18/34 (52%)

Query: 747  CNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETL 780
            C + G CT++   + C C P W G  C+ ++  L
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCL 2917


>gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]
          Length = 379

 Score =  122 bits (305), Expect = 6e-27
 Identities = 57/144 (39%), Positives = 75/144 (52%), Gaps = 7/144 (4%)

Query: 598 CACNSGYKGESCEEADCIDPGCSNHGVCIH-GECHCSPGWGGSNCEILKTMCPDQCSGHG 656
           C C  G+ G  CE+A C  P C N G+C+  G C C PG+ G NC+  K  C   C   G
Sbjct: 198 CECPDGFHGPHCEKALCT-PRCMNGGLCVTPGFCICPPGFYGVNCD--KANCSTTCFNGG 254

Query: 657 TYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGT-CRCEEGWTGPACNQRACHPR 715
           T     G C C P   G  C    C   C + G C+G + C+C +G+ G  C++  C P 
Sbjct: 255 TCFYP-GKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGDLCSKPVCEPG 313

Query: 716 CAEHGTCKD-GKCECSQGWNGEHC 738
           C  HGTC +  KC+C +GW+G HC
Sbjct: 314 CGAHGTCHEPNKCQCQEGWHGRHC 337



 Score =  120 bits (300), Expect = 2e-26
 Identities = 63/171 (36%), Positives = 86/171 (50%), Gaps = 11/171 (6%)

Query: 544 CSRAACPVLCSGNGQYSKGR-CLCFSGWKGTECDVPTTQCIDPQCGGRGICIM-GSCACN 601
           C +A CP  C   G  ++ R C C  G+ G  C+        P+C   G+C+  G C C 
Sbjct: 177 CQQAECPGGCRNGGFCNERRICECPDGFHGPHCE---KALCTPRCMNGGLCVTPGFCICP 233

Query: 602 SGYKGESCEEADCIDPGCSNHGVCIH-GECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQ 660
            G+ G +C++A+C    C N G C + G+C C PG  G  CEI K  CP  C   G  + 
Sbjct: 234 PGFYGVNCDKANC-STTCFNGGTCFYPGKCICPPGLEGEQCEISK--CPQPCRNGGKCIG 290

Query: 661 ESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMG-GTCRCEEGWTGPACNQR 710
           +S  C C   + G  CS  +C   CG+HG C     C+C+EGW G  CN+R
Sbjct: 291 KS-KCKCSKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCQEGWHGRHCNKR 340



 Score =  106 bits (264), Expect = 4e-22
 Identities = 65/187 (34%), Positives = 79/187 (42%), Gaps = 13/187 (6%)

Query: 497 NDGKNAEQVSFNTIVIESV--VECPRNCHGNGECVSGT-CHCFPGFLGPDCSRAACPVLC 553
           ++G    Q   N I  ++    ECP  C   G C     C C  GF GP C +A C   C
Sbjct: 159 SEGNTILQTPQNAIFFKTCQQAECPGGCRNGGFCNERRICECPDGFHGPHCEKALCTPRC 218

Query: 554 SGNGQ-YSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIM-GSCACNSGYKGESCEE 611
              G   + G C+C  G+ G  CD     C    C   G C   G C C  G +GE CE 
Sbjct: 219 MNGGLCVTPGFCICPPGFYGVNCD--KANC-STTCFNGGTCFYPGKCICPPGLEGEQCEI 275

Query: 612 ADCIDPGCSNHGVCI-HGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPN 670
           + C  P C N G CI   +C CS G+ G  C   K +C   C  HGT   E   C C   
Sbjct: 276 SKCPQP-CRNGGKCIGKSKCKCSKGYQGDLCS--KPVCEPGCGAHGT-CHEPNKCQCQEG 331

Query: 671 WTGPDCS 677
           W G  C+
Sbjct: 332 WHGRHCN 338



 Score =  106 bits (264), Expect = 4e-22
 Identities = 58/175 (33%), Positives = 79/175 (45%), Gaps = 10/175 (5%)

Query: 607 ESCEEADCIDPGCSNHGVCIHGE-CHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSC 665
           ++C++A+C   GC N G C     C C  G+ G +CE  K +C  +C   G  +   G C
Sbjct: 175 KTCQQAEC-PGGCRNGGFCNERRICECPDGFHGPHCE--KALCTPRCMNGGLCVTP-GFC 230

Query: 666 TCDPNWTGPDCSNEICSVDCGSHGVCM-GGTCRCEEGWTGPACNQRACHPRCAEHGTC-K 723
            C P + G +C    CS  C + G C   G C C  G  G  C    C   C   G C  
Sbjct: 231 ICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIG 290

Query: 724 DGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAME 778
             KC+CS+G+ G+ C+   C   C ++G C        C CQ GW G  C+   E
Sbjct: 291 KSKCKCSKGYQGDLCSKPVCEPGCGAHGTCHEPNK---CQCQEGWHGRHCNKRYE 342



 Score = 88.6 bits (218), Expect = 8e-17
 Identities = 49/156 (31%), Positives = 69/156 (44%), Gaps = 13/156 (8%)

Query: 648 CPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMG-GTCRCEEGWTGPA 706
           CP  C  +G +  E   C C   + GP C   +C+  C + G+C+  G C C  G+ G  
Sbjct: 182 CPGGCR-NGGFCNERRICECPDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGVN 240

Query: 707 CNQRACHPRCAEHGTC-KDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQ 765
           C++  C   C   GTC   GKC C  G  GE C I  CP  C + G+C        C C 
Sbjct: 241 CDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSK---CKCS 297

Query: 766 PGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCC 801
            G++G   D+  + +C       G     C +P+ C
Sbjct: 298 KGYQG---DLCSKPVCEPGCGAHG----TCHEPNKC 326


>gi|33598931 scavenger receptor class F, member 1 isoform 3
           precursor [Homo sapiens]
          Length = 569

 Score =  119 bits (298), Expect = 4e-26
 Identities = 99/337 (29%), Positives = 119/337 (35%), Gaps = 74/337 (21%)

Query: 515 VVECPRNCHGNGECVS-GTCHCFPGFLGPDCS------------RAACPVLCSGNGQYSK 561
           + E P  C  +  CV  G C C PGF G  CS            R +CP    G  + + 
Sbjct: 56  ICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPAT 115

Query: 562 GRCLCFSGWKGTECDVPTTQCIDPQCGGRGIC--IMGSCACNSGYKGESCEEADCIDPGC 619
           G C C +   G  C+ P        CG  G C    G C C  G+   +C    C     
Sbjct: 116 GACQCQADRWGARCEFPCA------CGPHGRCDPATGVCHCEPGWWSSTCRR-PCQCNTA 168

Query: 620 SNHGVCIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYL-QESGSCTCDPNWTGPDCSN 678
           +       G C C PGW G  C         +C+ HG+   Q+SG C C P W GP+C  
Sbjct: 169 AARCEQATGACVCKPGWWGRRCSF-------RCNCHGSPCEQDSGRCACRPGWWGPECQQ 221

Query: 679 EICSVDCGSHGVC--MGGTCRCEEGWTGPAC---------NQRACHP--RCAEHGTCK-- 723
           +   V     G C    G C C  G+ G  C           +  H   RC  +  C   
Sbjct: 222 QCECV----RGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPD 277

Query: 724 DGKCE-CSQGWNGEHCTIEGCPGL-----------CNSNGRCTLDQNGWHCV-CQPGWRG 770
            G CE C  GWNG  C     PG            C     C  D    HC  C PGW G
Sbjct: 278 TGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTG--HCQRCDPGWLG 335

Query: 771 AGCDVAMETLCTDSKDNEGDGLIDCMDP-DCCLQSSC 806
             C    E  C      E     DC      C+Q SC
Sbjct: 336 PRC----EDPCPTGTFGE-----DCGSTCPTCVQGSC 363



 Score =  110 bits (275), Expect = 2e-23
 Identities = 86/299 (28%), Positives = 112/299 (37%), Gaps = 61/299 (20%)

Query: 517 ECPRNCHGNGEC--VSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           E P  C  +G C   +G CHC PG+    C R       +   + + G C+C  GW G  
Sbjct: 130 EFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRR 189

Query: 575 CDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESC-EEADCIDPGCSNHGVCIHGECHCS 633
           C      C    C        G CAC  G+ G  C ++ +C+   CS       GEC C 
Sbjct: 190 CSF-RCNCHGSPCEQDS----GRCACRPGWWGPECQQQCECVRGRCS----AASGECTCP 240

Query: 634 PGWGGSNCEILKTMCP------------DQCSGHGTYLQESGSC-TCDPNWTGPDCS--- 677
           PG+ G+ CE+    CP             +C  +     ++GSC +C+P W G  C    
Sbjct: 241 PGFRGARCEL---PCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPC 297

Query: 678 -----NEICSVDCG--SHGVC----MGGTCRCEEGWTGPACNQ--------RACHPRC-- 716
                 E C   C    HG       G   RC+ GW GP C            C   C  
Sbjct: 298 LPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPT 357

Query: 717 AEHGTCK--DGKCECSQGWNGEHCTIEGCPGLCNSNG---RCTLDQNGWHCV---CQPG 767
              G+C    G C CS G+ G  C    CP   + N     C   +   H V   CQPG
Sbjct: 358 CVQGSCDTVTGDCVCSAGYWGPSCN-ASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPG 415



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 69/236 (29%), Positives = 92/236 (38%), Gaps = 41/236 (17%)

Query: 583 IDPQCGGRGICIMGS------CACNSGYKGESCEEADCIDP-GCSNHGVCIH-GECHCSP 634
           +DP+  G+ +C+  S      C      K + C    C  P  C    VC+  G C C P
Sbjct: 22  LDPK--GQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKP 79

Query: 635 GWGGSNCEILKTMCPDQ-----------CSGHGTYLQESGSCTCDPNWTGPDCSNEICSV 683
           G+ G++C    + CP Q           C  HG     +G+C C  +  G  C       
Sbjct: 80  GFFGAHCS---SRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCA-- 134

Query: 684 DCGSHGVC--MGGTCRCEEGWTGPACNQRACHPRCAEHGTCKD--GKCECSQGWNGEHCT 739
            CG HG C    G C CE GW    C +R C    A    C+   G C C  GW G  C+
Sbjct: 135 -CGPHGRCDPATGVCHCEPGWWSSTC-RRPCQCNTAA-ARCEQATGACVCKPGWWGRRCS 191

Query: 740 IEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDC 795
                  CN +G    +Q+   C C+PGW G  C    E  C   + +   G   C
Sbjct: 192 FR-----CNCHGS-PCEQDSGRCACRPGWWGPECQQQCE--CVRGRCSAASGECTC 239


>gi|33598929 scavenger receptor class F, member 1 isoform 1
           precursor [Homo sapiens]
          Length = 830

 Score =  119 bits (298), Expect = 4e-26
 Identities = 99/337 (29%), Positives = 119/337 (35%), Gaps = 74/337 (21%)

Query: 515 VVECPRNCHGNGECVS-GTCHCFPGFLGPDCS------------RAACPVLCSGNGQYSK 561
           + E P  C  +  CV  G C C PGF G  CS            R +CP    G  + + 
Sbjct: 56  ICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPAT 115

Query: 562 GRCLCFSGWKGTECDVPTTQCIDPQCGGRGIC--IMGSCACNSGYKGESCEEADCIDPGC 619
           G C C +   G  C+ P        CG  G C    G C C  G+   +C    C     
Sbjct: 116 GACQCQADRWGARCEFPCA------CGPHGRCDPATGVCHCEPGWWSSTCRR-PCQCNTA 168

Query: 620 SNHGVCIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYL-QESGSCTCDPNWTGPDCSN 678
           +       G C C PGW G  C         +C+ HG+   Q+SG C C P W GP+C  
Sbjct: 169 AARCEQATGACVCKPGWWGRRCSF-------RCNCHGSPCEQDSGRCACRPGWWGPECQQ 221

Query: 679 EICSVDCGSHGVC--MGGTCRCEEGWTGPAC---------NQRACHP--RCAEHGTCK-- 723
           +   V     G C    G C C  G+ G  C           +  H   RC  +  C   
Sbjct: 222 QCECV----RGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPD 277

Query: 724 DGKCE-CSQGWNGEHCTIEGCPGL-----------CNSNGRCTLDQNGWHCV-CQPGWRG 770
            G CE C  GWNG  C     PG            C     C  D    HC  C PGW G
Sbjct: 278 TGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTG--HCQRCDPGWLG 335

Query: 771 AGCDVAMETLCTDSKDNEGDGLIDCMDP-DCCLQSSC 806
             C    E  C      E     DC      C+Q SC
Sbjct: 336 PRC----EDPCPTGTFGE-----DCGSTCPTCVQGSC 363



 Score =  110 bits (275), Expect = 2e-23
 Identities = 86/299 (28%), Positives = 112/299 (37%), Gaps = 61/299 (20%)

Query: 517 ECPRNCHGNGEC--VSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           E P  C  +G C   +G CHC PG+    C R       +   + + G C+C  GW G  
Sbjct: 130 EFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRR 189

Query: 575 CDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESC-EEADCIDPGCSNHGVCIHGECHCS 633
           C      C    C        G CAC  G+ G  C ++ +C+   CS       GEC C 
Sbjct: 190 CSF-RCNCHGSPCEQDS----GRCACRPGWWGPECQQQCECVRGRCS----AASGECTCP 240

Query: 634 PGWGGSNCEILKTMCP------------DQCSGHGTYLQESGSC-TCDPNWTGPDCS--- 677
           PG+ G+ CE+    CP             +C  +     ++GSC +C+P W G  C    
Sbjct: 241 PGFRGARCEL---PCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPC 297

Query: 678 -----NEICSVDCG--SHGVC----MGGTCRCEEGWTGPACNQ--------RACHPRC-- 716
                 E C   C    HG       G   RC+ GW GP C            C   C  
Sbjct: 298 LPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPT 357

Query: 717 AEHGTCK--DGKCECSQGWNGEHCTIEGCPGLCNSNG---RCTLDQNGWHCV---CQPG 767
              G+C    G C CS G+ G  C    CP   + N     C   +   H V   CQPG
Sbjct: 358 CVQGSCDTVTGDCVCSAGYWGPSCN-ASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPG 415



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 69/236 (29%), Positives = 92/236 (38%), Gaps = 41/236 (17%)

Query: 583 IDPQCGGRGICIMGS------CACNSGYKGESCEEADCIDP-GCSNHGVCIH-GECHCSP 634
           +DP+  G+ +C+  S      C      K + C    C  P  C    VC+  G C C P
Sbjct: 22  LDPK--GQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKP 79

Query: 635 GWGGSNCEILKTMCPDQ-----------CSGHGTYLQESGSCTCDPNWTGPDCSNEICSV 683
           G+ G++C    + CP Q           C  HG     +G+C C  +  G  C       
Sbjct: 80  GFFGAHCS---SRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCA-- 134

Query: 684 DCGSHGVC--MGGTCRCEEGWTGPACNQRACHPRCAEHGTCKD--GKCECSQGWNGEHCT 739
            CG HG C    G C CE GW    C +R C    A    C+   G C C  GW G  C+
Sbjct: 135 -CGPHGRCDPATGVCHCEPGWWSSTC-RRPCQCNTAA-ARCEQATGACVCKPGWWGRRCS 191

Query: 740 IEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDC 795
                  CN +G    +Q+   C C+PGW G  C    E  C   + +   G   C
Sbjct: 192 FR-----CNCHGS-PCEQDSGRCACRPGWWGPECQQQCE--CVRGRCSAASGECTC 239


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score =  119 bits (297), Expect = 5e-26
 Identities = 99/387 (25%), Positives = 145/387 (37%), Gaps = 102/387 (26%)

Query: 522 CHGNGECV------SGTCHCFPGFLGP-------DCSRAACPV--LCSGNGQYSKGRCLC 566
           C G+  CV      S  C C PG+ G         C + +C    +C  +  Y    C+C
Sbjct: 79  CQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPV--CIC 136

Query: 567 FSGWKGTECDVPTTQCIDPQCGGRGICIMG----SCACNSGYKGESC--EEADCIDPGCS 620
            +G+ G  C++   +C    C    +C  G    SC C  GY+G  C  E  +C    C 
Sbjct: 137 PAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCK 196

Query: 621 NHGVCIHG----ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGS---CTCDPNWTG 673
           N   C++      C C   + G NCE+    C  Q   +G   Q++     C C P + G
Sbjct: 197 NEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLG 256

Query: 674 PDC---SNEICSVDCGSHGVCMGG----TCRCE-EGWTG-------PACNQRACHPRCAE 718
             C   ++E  S  C   G+C+ G    +C C   G+TG       P C  + CH     
Sbjct: 257 DHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCH----N 312

Query: 719 HGTCKDG----KCECSQGWNGEHCTI---EGCPGLCNSNGRCTL---------------- 755
           + TC+D      C C  G+ G  C I   E     C SNG C                  
Sbjct: 313 NATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSS 372

Query: 756 ----DQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPY 811
               + +G+ C+CQPG+ G  C+                      D + C  + CQN   
Sbjct: 373 FSYHEASGYVCICQPGFTGIHCE---------------------EDVNECSSNPCQNGGT 411

Query: 812 CRGLPDPQDIISQSLQSPSQQAAKSFY 838
           C  LP      + +   P    +++FY
Sbjct: 412 CENLPG-----NYTCHCPFDNLSRTFY 433



 Score =  114 bits (286), Expect = 1e-24
 Identities = 86/287 (29%), Positives = 120/287 (41%), Gaps = 39/287 (13%)

Query: 537 PGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGIC--- 593
           P F  P C  +A  V   G   +    C C  G+ GT C+     C    C   GIC   
Sbjct: 73  PCFSNP-CQGSATCVNTPGERSFL---CKCPPGYSGTICETTIGSCGKNSCQHGGICHQD 128

Query: 594 -IMGSCACNSGYKGESCE--EADCIDPGCSNHGVCIHG----ECHCSPGWGGSNCEILKT 646
            I   C C +GY G  CE    +C    C N  VC  G     C C PG+ G +C++   
Sbjct: 129 PIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVD 188

Query: 647 MCP-DQCSGHGTYLQESG--SCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCR------ 697
            C  D C    T L E G  +C C  N++G +C  EI   +C S     G TC+      
Sbjct: 189 ECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEID--ECWSQPCLNGATCQDALGAY 246

Query: 698 ---CEEGWTGPAC--NQRACHPR-CAEHGTCKDGK----CECS-QGWNGEHCT--IEGCP 744
              C  G+ G  C  N   C  + C   G C DG+    C C+  G+ G HC   +  C 
Sbjct: 247 FCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCW 306

Query: 745 GL-CNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGD 790
              C++N  C    + + C C PG+ GA C++ +    ++   + G+
Sbjct: 307 SKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGE 353



 Score =  105 bits (263), Expect = 5e-22
 Identities = 90/351 (25%), Positives = 145/351 (41%), Gaps = 81/351 (23%)

Query: 517 ECPRN-CHGNGECVSG----TCHCFPGFLG-------PDCSRAACPVLCSGNGQYSKGRC 564
           EC  + C     C  G    +C C PG+ G        +C+   C    +   +  +  C
Sbjct: 151 ECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTC 210

Query: 565 LCFSGWKGTECDVPTTQCIDPQCGGRGIC--IMGS--CACNSGYKGESCE--EADCIDPG 618
           +C   + G  C++   +C    C     C   +G+  C C  G+ G+ CE    +C    
Sbjct: 211 ICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQP 270

Query: 619 CSNHGVCIHGE----CHCS-PGWGGSNCEILKTMCPDQ-CSGHGTYLQ--ESGSCTCDPN 670
           C + G+C+ GE    C+C+  G+ G++CE L  +C  + C  + T     ++ +C C P 
Sbjct: 271 CLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPG 330

Query: 671 WTGPDCS---NEICSVDCGSHGVCM------------------------GGTCRCEEGWT 703
           +TG  C    NE  S  C S+G C+                        G  C C+ G+T
Sbjct: 331 YTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFT 390

Query: 704 GPAC----NQRACHPRCAEHGTCKD----GKCECSQG------WNGEHCT--IEGCPGL- 746
           G  C    N+ + +P C   GTC++      C C         + G  C+  + GC    
Sbjct: 391 GIHCEEDVNECSSNP-CQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQ 449

Query: 747 CNSNGRCTLD----QNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLI 793
           C +NG C       Q+G+ C+C  G+ G+ C++A       +   EGDG +
Sbjct: 450 CLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIA------TTLSFEGDGFL 494



 Score = 75.9 bits (185), Expect = 5e-13
 Identities = 55/198 (27%), Positives = 77/198 (38%), Gaps = 36/198 (18%)

Query: 614  CIDPGCSNHGVCIHG----------ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESG 663
            C+     N   C+HG           C C  GW G +CE+    C      HG       
Sbjct: 1137 CLQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVA 1196

Query: 664  S--CTCDPNWTGPDCSNEI--C-SVDCGSHGVCM----GGTCRCEEGWTGPACNQ----- 709
            +  CTC+P +TG +C  +I  C S  C +   C+    G +C C   +TG  C Q     
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPS 1256

Query: 710  -----RACHPRCAEHGTCKDG----KCECSQGWNGEHCT--IEGCPG-LCNSNGRCTLDQ 757
                    +  C   G C +     KC C  G+ GE C   I+ C    C + G C    
Sbjct: 1257 TVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLL 1316

Query: 758  NGWHCVCQPGWRGAGCDV 775
            N + C+C   + G  C+V
Sbjct: 1317 NKFQCLCDVAFAGERCEV 1334



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 56/218 (25%), Positives = 77/218 (35%), Gaps = 55/218 (25%)

Query: 550  PVLCSGNGQ--YSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGE 607
            P L  GN +  YS   C C  GW G  C++   +C    C                    
Sbjct: 1147 PCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPC-------------------- 1186

Query: 608  SCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCEILKTMCPD-QCSGHGTYLQESG--S 664
                   I   CS+     H  C   PG+ G NCE+    C   QC+   T +  +   S
Sbjct: 1187 -------IHGNCSDRVAAYHCTC--EPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYS 1237

Query: 665  CTCDPNWTG----------PDCSNEICSVDCGSHGVCMGG----TCRCEEGWTGPACNQ- 709
            C C  N+TG            C NE  ++ C + G C        C C  G+TG  C + 
Sbjct: 1238 CLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKD 1297

Query: 710  --RACHPRCAEHGTCKD----GKCECSQGWNGEHCTIE 741
                    C   G C+D     +C C   + GE C ++
Sbjct: 1298 IDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVD 1335



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 57/227 (25%), Positives = 84/227 (37%), Gaps = 50/227 (22%)

Query: 614 CIDPGCSNHGVCIH----GECHCSPGWGG--SNCEILKTMC-PDQCSGHGTYLQESGS-- 664
           C+   C N+  C       +C CS        +C+ +K  C  + C G  T +   G   
Sbjct: 34  CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERS 93

Query: 665 --CTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTC 722
             C C P ++G  C   I S  CG +    GG C           +Q   +P C      
Sbjct: 94  FLCKCPPGYSGTICETTIGS--CGKNSCQHGGIC-----------HQDPIYPVCI----- 135

Query: 723 KDGKCECSQGWNGEHCTI---EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMET 779
                 C  G+ G  C I   E     C +   C    +G+ C C PG++G  CD+ ++ 
Sbjct: 136 ------CPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDE 189

Query: 780 LCTDSKDNEGD-----GLIDCMDP------DCCLQ-SSCQNQPYCRG 814
             +D   NE       G   C+ P      +C L+   C +QP   G
Sbjct: 190 CASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNG 236



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 44/158 (27%), Positives = 63/158 (39%), Gaps = 28/158 (17%)

Query: 514  SVVECPRNCHGNGECVSGT----CHCFPGFLGPDCSRAA--CPVLCSGNG----QYSKG- 562
            ++ EC  N   +G C        C C PG+ G +C      C      NG     ++ G 
Sbjct: 1177 NIDECFSNPCIHGNCSDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGY 1236

Query: 563  RCLCFSGWKGTEC---DVPTTQCIDPQ----CGGRGICIMG----SCACNSGYKGESCEE 611
             CLCF  + G  C    +P+T C + +    C   G C        C C  G+ GE CE+
Sbjct: 1237 SCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEK 1296

Query: 612  --ADCIDPGCSNHGVC----IHGECHCSPGWGGSNCEI 643
               +C    C N G+C       +C C   + G  CE+
Sbjct: 1297 DIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEV 1334


>gi|145309306 scavenger receptor class F, member 1 isoform 5
           precursor [Homo sapiens]
          Length = 744

 Score =  118 bits (296), Expect = 7e-26
 Identities = 90/282 (31%), Positives = 107/282 (37%), Gaps = 67/282 (23%)

Query: 515 VVECPRNCHGNGECVS-GTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGT 573
           + E P  C  +  CV  G C C PGF G  CS + CP      GQY          W G 
Sbjct: 56  ICEGPDACQKDEVCVKPGLCRCKPGFFGAHCS-SRCP------GQY----------W-GP 97

Query: 574 ECDVPTTQCIDPQCGGRGIC--IMGSCACNSGYKGESCEEADCIDPGCSNHGVC--IHGE 629
           +C      C    C   G C    G+C C +   G  CE        C  HG C    G 
Sbjct: 98  DC---RESC---PCHPHGQCEPATGACQCQADRWGARCE----FPCACGPHGRCDPATGV 147

Query: 630 CHCSPGWGGSNCEILKTMCPDQCSGHGTYLQES-GSCTCDPNWTGPDCSNEICSVDCGSH 688
           CHC PGW  S C       P QC+      +++ G+C C P W G       CS  C  H
Sbjct: 148 CHCEPGWWSSTCRR-----PCQCNTAAARCEQATGACVCKPGWWG-----RRCSFRCNCH 197

Query: 689 GVCM---GGTCRCEEGWTGPACNQRACHPRCAEHGTCK--DGKCECSQGWNGEHCTIEGC 743
           G       G C C  GW GP C Q+     C   G C    G+C C  G+ G  C +  C
Sbjct: 198 GSPCEQDSGRCACRPGWWGPECQQQC---ECVR-GRCSAASGECTCPPGFRGARCELP-C 252

Query: 744 P------------GLCNSNGRCTLDQNGWHCVCQPGWRGAGC 773
           P            G C  N  C+ D       C+PGW G  C
Sbjct: 253 PAGSHGVQCAHSCGRCKHNEPCSPDTGSCES-CEPGWNGTQC 293



 Score =  100 bits (250), Expect = 1e-20
 Identities = 70/227 (30%), Positives = 91/227 (40%), Gaps = 34/227 (14%)

Query: 566 CFSGW--KGTECDVPTTQCIDPQCGGRGICIM-GSCACNSGYKGESCEEA--------DC 614
           C +GW  K  EC +P  +  D  C    +C+  G C C  G+ G  C           DC
Sbjct: 41  CCAGWRQKDQECTIPICEGPDA-CQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDC 99

Query: 615 IDP-GCSNHGVC--IHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNW 671
            +   C  HG C    G C C     G+ CE      P  C  HG     +G C C+P W
Sbjct: 100 RESCPCHPHGQCEPATGACQCQADRWGARCEF-----PCACGPHGRCDPATGVCHCEPGW 154

Query: 672 TGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGT-CKD--GKCE 728
               C          +      G C C+ GW G     R C  RC  HG+ C+   G+C 
Sbjct: 155 WSSTCRRPCQCNTAAARCEQATGACVCKPGWWG-----RRCSFRCNCHGSPCEQDSGRCA 209

Query: 729 CSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDV 775
           C  GW G  C  + C  +    GRC+       C C PG+RGA C++
Sbjct: 210 CRPGWWGPECQ-QQCECV---RGRCSAASG--ECTCPPGFRGARCEL 250



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 69/236 (29%), Positives = 92/236 (38%), Gaps = 41/236 (17%)

Query: 583 IDPQCGGRGICIMGS------CACNSGYKGESCEEADCIDP-GCSNHGVCIH-GECHCSP 634
           +DP+  G+ +C+  S      C      K + C    C  P  C    VC+  G C C P
Sbjct: 22  LDPK--GQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKP 79

Query: 635 GWGGSNCEILKTMCPDQ-----------CSGHGTYLQESGSCTCDPNWTGPDCSNEICSV 683
           G+ G++C    + CP Q           C  HG     +G+C C  +  G  C       
Sbjct: 80  GFFGAHCS---SRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCA-- 134

Query: 684 DCGSHGVC--MGGTCRCEEGWTGPACNQRACHPRCAEHGTCKD--GKCECSQGWNGEHCT 739
            CG HG C    G C CE GW    C +R C    A    C+   G C C  GW G  C+
Sbjct: 135 -CGPHGRCDPATGVCHCEPGWWSSTC-RRPCQCNTAA-ARCEQATGACVCKPGWWGRRCS 191

Query: 740 IEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDC 795
                  CN +G    +Q+   C C+PGW G  C    E  C   + +   G   C
Sbjct: 192 FR-----CNCHGS-PCEQDSGRCACRPGWWGPECQQQCE--CVRGRCSAASGECTC 239



 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 74/241 (30%), Positives = 96/241 (39%), Gaps = 51/241 (21%)

Query: 517 ECPRNCHGNGEC--VSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
           E P  C  +G C   +G CHC PG+    C R       +   + + G C+C  GW G  
Sbjct: 130 EFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRR 189

Query: 575 CDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESC-EEADCIDPGCSNHGVCIHGECHCS 633
           C      C    C        G CAC  G+ G  C ++ +C+   CS       GEC C 
Sbjct: 190 CSF-RCNCHGSPCEQDS----GRCACRPGWWGPECQQQCECVRGRCS----AASGECTCP 240

Query: 634 PGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMG 693
           PG+ G+ CE+     P     HG  +Q + SC       G    NE CS D GS   C  
Sbjct: 241 PGFRGARCEL-----PCPAGSHG--VQCAHSC-------GRCKHNEPCSPDTGS---CES 283

Query: 694 GTCRCEEGWTGPACNQ--------RACHPRCAEHGTCKDGK-CECSQGWNGEHCTIEGCP 744
               CE GW G  C Q         +C  +C     C+ G+ CE   G    HC  + C 
Sbjct: 284 ----CEPGWNGTQCQQPCLPGTFGESCEQQCPH---CRHGEACEPDTG----HC--QRCS 330

Query: 745 G 745
           G
Sbjct: 331 G 331


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score =  113 bits (283), Expect = 2e-24
 Identities = 85/290 (29%), Positives = 117/290 (40%), Gaps = 53/290 (18%)

Query: 522 CHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQY--SKGRCLCFSGWKGTECDVPT 579
           C   GE V     C PG+ GP C+   C   C     +    G C C  GW+G  CD   
Sbjct: 204 CGERGEKV-----CNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD--- 255

Query: 580 TQCIDPQCGGRGICIMG-SCACNSGYKGESCEEADCIDPGCSNHGVCIHGE--------- 629
            +CI       G C     C C  G+ G  C +       C++H  C +G          
Sbjct: 256 -ECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNY---CTHHKPCKNGATCTNTGQGS 311

Query: 630 --CHCSPGWGGSNCEILKTMC-PDQCSGHG--TYLQESGSCTCDPNWTGPDCSNEICSVD 684
             C C PG+ G+ CE+    C P  C   G  T L+ S SCTC P + G  C  E+ ++ 
Sbjct: 312 YTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKIC--ELSAMT 369

Query: 685 CGSHGVCMGG-----------TCRCEEGWTGPACNQRACH---PRCAEHGTCKD----GK 726
           C   G C  G           +CRC  G++G  C ++  +     C+    C D      
Sbjct: 370 CAD-GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYL 428

Query: 727 CECSQGWNGEHC--TIEGCPGL-CNSNGRCTLDQNGWHCVCQPGWRGAGC 773
           C C  G++G HC   ++ C    C + G C    N + C C PG+ G  C
Sbjct: 429 CRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478



 Score =  106 bits (265), Expect = 3e-22
 Identities = 81/283 (28%), Positives = 113/283 (39%), Gaps = 33/283 (11%)

Query: 531 GTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQ-CGG 589
           G C C  G+ G  C        C         +C C  GW G  C+     C   + C  
Sbjct: 241 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN 300

Query: 590 RGICI---MGS--CACNSGYKGESCEEA--DCIDPGCSNHGVCIHGE----CHCSPGWGG 638
              C     GS  C+C  GY G +CE    +C    C N G C   E    C C PG+ G
Sbjct: 301 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG 360

Query: 639 SNCEILKTMCPDQCSGHGTYLQESG----SCTCDPNWTGPDCSNEI--CSVDCGSHG--- 689
             CE+    C D    +G    +S     SC C   ++G +C  +I  CS    S+G   
Sbjct: 361 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC 420

Query: 690 VCMGGT--CRCEEGWTGPACNQRA---CHPRCAEHGTCKDG----KCECSQGWNGEHCT- 739
           V +G    CRC+ G++G  C+          CA  GTC+DG     C C  G+ G +C+ 
Sbjct: 421 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA 480

Query: 740 -IEGCP-GLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETL 780
            +  C    C++   C    + + C C  G+ G  C   +  L
Sbjct: 481 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPEL 523



 Score =  106 bits (264), Expect = 4e-22
 Identities = 77/253 (30%), Positives = 95/253 (37%), Gaps = 41/253 (16%)

Query: 600 CNSGYKGESCEEADCIDPGCSNHGVC-IHGECHCSPGWGGSNCEILKTMCPDQCSGHGTY 658
           C+  Y GE C            H  C   GE  C+PGW G  C   + +C   C     +
Sbjct: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCT--EPICLPGCDEQHGF 236

Query: 659 LQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGG-TCRCEEGWTGPACNQRACHPRCA 717
             + G C C   W G  C   I    C  HG C     C C+EGW G  CNQ   +  C 
Sbjct: 237 CDKPGECKCRVGWQGRYCDECIRYPGC-LHGTCQQPWQCNCQEGWGGLFCNQDLNY--CT 293

Query: 718 EHGTCKDGK-----------CECSQGWNGEHCT--IEGC-PGLCNSNGRCTLDQNGWHCV 763
            H  CK+G            C C  G+ G  C   I+ C P  C + G CT  +N + C 
Sbjct: 294 HHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCT 353

Query: 764 CQPGWRGAGCDVAMETLCTDSKDNEG-------DGLIDCMDP------------DCCLQS 804
           C PG+ G  C+++  T C D     G       DG   C  P            D C  S
Sbjct: 354 CPPGFYGKICELSAMT-CADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSS 412

Query: 805 SCQNQPYCRGLPD 817
            C N   C  L D
Sbjct: 413 PCSNGAKCVDLGD 425



 Score =  103 bits (256), Expect = 3e-21
 Identities = 82/274 (29%), Positives = 105/274 (38%), Gaps = 65/274 (23%)

Query: 587 CGGRGICIMGSCACNSGYKGESCEEADCIDPGC-SNHGVCIH-GECHCSPGWGGSNCEIL 644
           CG RG  +     CN G+KG  C E  C+ PGC   HG C   GEC C  GW G  C   
Sbjct: 204 CGERGEKV-----CNPGWKGPYCTEPICL-PGCDEQHGFCDKPGECKCRVGWQGRYC--- 254

Query: 645 KTMCPDQCSG-----HGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGG----- 694
                D+C       HGT  Q+   C C   W G  C+ ++    C  H  C  G     
Sbjct: 255 -----DECIRYPGCLHGT-CQQPWQCNCQEGWGGLFCNQDLNY--CTHHKPCKNGATCTN 306

Query: 695 ------TCRCEEGWTGPACNQ--RACHPR-CAEHGTCKD----GKCECSQGWNGEHCTIE 741
                 TC C  G+TG  C      C P  C   G+C D      C C  G+ G+ C + 
Sbjct: 307 TGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELS 366

Query: 742 G---CPGLCNSNGRCT-LDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMD 797
                 G C + GRC+     G+ C C  G+ G  C+  ++  C+ S  + G   +D  D
Sbjct: 367 AMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKID-YCSSSPCSNGAKCVDLGD 425

Query: 798 P------------------DCCLQSSCQNQPYCR 813
                              D C  S C N   CR
Sbjct: 426 AYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCR 459



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 73/257 (28%), Positives = 100/257 (38%), Gaps = 49/257 (19%)

Query: 528 CVSGTC------HCFPGFLGPDCSR--------AACP--VLCSGNGQYSKGRCLCFSGWK 571
           C+ GTC      +C  G+ G  C++          C     C+  GQ S   C C  G+ 
Sbjct: 263 CLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSY-TCSCRPGYT 321

Query: 572 GTECDVPTTQCIDPQCGGRGICI----MGSCACNSGYKGESCEEA--DCIDPGCSNHGVC 625
           G  C++   +C    C   G C       SC C  G+ G+ CE +   C D  C N G C
Sbjct: 322 GATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRC 381

Query: 626 IHG-----ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGS---CTCDPNWTGPDCS 677
                    C C  G+ G NCE     C      +G    + G    C C   ++G  C 
Sbjct: 382 SDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD 441

Query: 678 NEICSVDCGSHGVCMGGTCR---------CEEGWTGPACN---QRACHPRCAEHGTCKDG 725
           + +   DC S     GGTCR         C  G+TG  C+    R  H  C    TC + 
Sbjct: 442 DNVD--DCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER 499

Query: 726 K----CECSQGWNGEHC 738
                CEC++G+ G +C
Sbjct: 500 GHRYVCECARGYGGPNC 516



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 53/194 (27%), Positives = 63/194 (32%), Gaps = 61/194 (31%)

Query: 517 EC-PRNCHGNGECV----SGTCHCFPGFLGPDCSRAA----------------------- 548
           EC P  C   G C     S +C C PGF G  C  +A                       
Sbjct: 331 ECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYS 390

Query: 549 --CPVLCSG-----------NGQYSKGR----------CLCFSGWKGTECDVPTTQCIDP 585
             CPV  SG           +   S G           C C +G+ G  CD     C   
Sbjct: 391 CRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS 450

Query: 586 QCGGRGICIMG----SCACNSGYKGESCEE--ADCIDPGCSNHGVCIHGE----CHCSPG 635
            C   G C  G    SC C  GY G +C    + C    C N   C        C C+ G
Sbjct: 451 PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG 510

Query: 636 WGGSNCEILKTMCP 649
           +GG NC+ L    P
Sbjct: 511 YGGPNCQFLLPELP 524


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,504,181
Number of Sequences: 37866
Number of extensions: 5097662
Number of successful extensions: 21860
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 292
Number of HSP's that attempted gapping in prelim test: 13312
Number of HSP's gapped (non-prelim): 2856
length of query: 2699
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2579
effective length of database: 13,703,598
effective search space: 35341579242
effective search space used: 35341579242
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.