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Search of human proteins with 31317292
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1
[Homo sapiens]
(757 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 1570 0.0
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 1503 0.0
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 1146 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 466 e-131
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 459 e-129
gi|222352183 neural precursor cell expressed, developmentally do... 456 e-128
gi|21361472 neural precursor cell expressed, developmentally dow... 456 e-128
gi|222352094 neural precursor cell expressed, developmentally do... 456 e-128
gi|222352092 neural precursor cell expressed, developmentally do... 456 e-128
gi|222352090 neural precursor cell expressed, developmentally do... 456 e-128
gi|222352088 neural precursor cell expressed, developmentally do... 456 e-128
gi|222352086 neural precursor cell expressed, developmentally do... 456 e-128
gi|222352084 neural precursor cell expressed, developmentally do... 456 e-128
gi|222352082 neural precursor cell expressed, developmentally do... 456 e-128
gi|114520609 neural precursor cell expressed, developmentally do... 448 e-126
gi|114520607 neural precursor cell expressed, developmentally do... 448 e-126
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 447 e-125
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 430 e-120
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 360 2e-99
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 360 2e-99
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 330 3e-90
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 272 1e-72
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 197 2e-50
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 197 2e-50
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 197 2e-50
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 192 1e-48
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 187 2e-47
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 176 5e-44
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 176 7e-44
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 176 7e-44
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 1570 bits (4066), Expect = 0.0
Identities = 757/757 (100%), Positives = 757/757 (100%)
Query: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
Sbjct: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
Query: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
Sbjct: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
Query: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA 180
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
Sbjct: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA 180
Query: 181 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY 240
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
Sbjct: 181 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY 240
Query: 241 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV 300
EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
Sbjct: 241 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV 300
Query: 301 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS 360
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
Sbjct: 301 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS 360
Query: 361 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR 420
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
Sbjct: 361 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR 420
Query: 421 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS 480
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
Sbjct: 421 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS 480
Query: 481 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV 540
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
Sbjct: 481 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV 540
Query: 541 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI 600
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
Sbjct: 541 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI 600
Query: 601 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR 660
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
Sbjct: 601 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR 660
Query: 661 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP 720
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
Sbjct: 661 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP 720
Query: 721 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 757
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
Sbjct: 721 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 757
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 1503 bits (3890), Expect = 0.0
Identities = 731/757 (96%), Positives = 731/757 (96%), Gaps = 26/757 (3%)
Query: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
Sbjct: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
Query: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
Sbjct: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
Query: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA 180
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
Sbjct: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA 180
Query: 181 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY 240
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
Sbjct: 181 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY 240
Query: 241 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV 300
EQRTTVQGQVYFLHTQTGVSTWHDPRIP RDLNSV
Sbjct: 241 EQRTTVQGQVYFLHTQTGVSTWHDPRIP--------------------------RDLNSV 274
Query: 301 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS 360
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
Sbjct: 275 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS 334
Query: 361 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR 420
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
Sbjct: 335 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR 394
Query: 421 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS 480
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
Sbjct: 395 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS 454
Query: 481 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV 540
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
Sbjct: 455 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV 514
Query: 541 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI 600
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
Sbjct: 515 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI 574
Query: 601 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR 660
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
Sbjct: 575 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR 634
Query: 661 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP 720
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
Sbjct: 635 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP 694
Query: 721 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 757
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
Sbjct: 695 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 1146 bits (2965), Expect = 0.0
Identities = 573/792 (72%), Positives = 636/792 (80%), Gaps = 79/792 (9%)
Query: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
MSNPG RRNG +K+RLTVLCAKNL KKDFFRLPDPFAK+VVDGSGQCHSTDTVKNTLDP
Sbjct: 1 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDP 59
Query: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
KWNQHYDLY+GK+DS+TISVWNHKKIHKKQGAGFLGCVRLLSNAI+RLKDTGYQRLDLCK
Sbjct: 60 KWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCK 119
Query: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY----- 163
L P+D D VRGQIVVSLQ+RDRIGTGG VVDC L +N+ G +
Sbjct: 120 LGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHI 179
Query: 164 --------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQA 209
E S PGRPLSCF++E P + + GA G S D RL
Sbjct: 180 TRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAE 230
Query: 210 QRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS 269
+R+R+ R + +R H H P+LPEGYEQRTT QGQVYFLHTQTGVSTWHDPR+
Sbjct: 231 RRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRV-- 284
Query: 270 PSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNN 329
PRDL+++NC+ELGPLPPGWE+R+T +GR+YFVDHNN
Sbjct: 285 ------------------------PRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNN 320
Query: 330 RTTQFTDPR----LHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVL 385
RTTQFTDPR LH ++N Q QLK+ Q + S + E L RY+RDLVQKLK+L
Sbjct: 321 RTTQFTDPRLSANLHLVLNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKIL 379
Query: 386 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAR 445
R ELS QQPQAGHCRIEVSREEIFEESYRQ+MKMRPKDL KRLM+KFRGEEGLDYGGVAR
Sbjct: 380 RQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR 439
Query: 446 EWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHY 505
EWLYLL HEMLNPYYGLFQYS D+IY LQINPDS++NP+HLSYFHFVGRIMG+AVFHGHY
Sbjct: 440 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY 499
Query: 506 INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRI 565
I+GGFT+PFYKQLLGK I L D+E VDP+LH SLVWILENDIT VLDHTFCVEHNA+G I
Sbjct: 500 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEI 559
Query: 566 LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ 625
+QHELKPNG+++PV EENKKEYVRLYVNWRF+RGIEAQFLALQKGFNE+IPQHLLK FD+
Sbjct: 560 IQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDE 619
Query: 626 KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGST 685
KELELII GL KID+NDWK NTRLKHC DSNIV+WFW+AVE FDEERRARLLQFVTGS+
Sbjct: 620 KELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSS 679
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVPLQGFKALQ GAAGPRLFTIH IDA T+NLPKAHTCFNRIDIPPYESYEKLYEKLL
Sbjct: 680 RVPLQGFKALQ---GAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLL 736
Query: 746 TAVEETCGFAVE 757
TA+EETCGFAVE
Sbjct: 737 TAIEETCGFAVE 748
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 466 bits (1199), Expect = e-131
Identities = 246/551 (44%), Positives = 338/551 (61%), Gaps = 36/551 (6%)
Query: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFL 286
LP G+E+R G++Y++ T +TW P + S + G F F+
Sbjct: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFI 378
Query: 287 LQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 346
G+ S D LGPLPPGWE R+ +GR+YFV+HN R TQ+ DPR +N +
Sbjct: 379 Y-GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEK 437
Query: 347 -----CQLKEPSQPLPL-------------PSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
+++ +P P G + P Y RD K++ R
Sbjct: 438 PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFW 497
Query: 389 LS-LQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L PQ H +I V+R+ +FE+S++QIM P+DL++RL V F GEEGLDYGGVAREW
Sbjct: 498 CQQLAMPQ--HIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREW 555
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYIN 507
+LL HE+LNP Y LF+Y+ + Y LQINP S INPDHL YF F+GR + +A+FHG +I+
Sbjct: 556 FFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFID 615
Query: 508 GGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRIL 566
GF++PFYK++L KP+ L DLES+DPE + SL+W+ EN+I L+ F V+ G I
Sbjct: 616 TGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIK 675
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
H+LKPNG N+ VTEENK+EY+R+ WR RG+E Q A +GFNE++PQ L+ FD K
Sbjct: 676 SHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAK 735
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTR 686
ELE+++ G+ +IDLNDW+ + +H S + WFWQ V+ D E+R RLLQFVTG+ R
Sbjct: 736 ELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCR 795
Query: 687 VPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLT 746
+P+ GF L GS GP+ F I + + LP++HTCFNR+D+PPY+SYE+L EKLL
Sbjct: 796 LPVGGFADLMGSN---GPQKFCIEKV-GKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLF 851
Query: 747 AVEETCGFAVE 757
A+EET GF E
Sbjct: 852 AIEETEGFGQE 862
Score = 75.1 bits (183), Expect = 2e-13
Identities = 73/326 (22%), Positives = 120/326 (36%), Gaps = 30/326 (9%)
Query: 14 KIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKT 73
++++TV+ AK K + P P+ ++ VDG Q T+ NT PKW Q + V
Sbjct: 19 QLQITVISAKLKENKKNWFGPSPYVEVTVDG--QSKKTEKCNNTNSPKWKQPLTVIVTPV 76
Query: 74 DSITISVWNHKKIHKKQ--GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRG 131
+ VW+H+ + G L L + +L++ P++T
Sbjct: 77 SKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLS 136
Query: 132 QIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAG 191
+ LQ + T G +N+ + + D T +
Sbjct: 137 ICLDGLQLESEVVTNGETTCSESASQND------------------DGSRSKDETRVSTN 178
Query: 192 GGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVY 251
G + +++R+ +P + P P + P P + +V G
Sbjct: 179 GSDDPEDAGAGENRRVSGNN--SPSLSNGGFKPSRPPRPSRPP--PPTPRRPASVNGSPS 234
Query: 252 FLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPG 311
G ST P + + T G + + + G S PR LN V PLPPG
Sbjct: 235 ATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGG-SGPRPLNPVT---QAPLPPG 290
Query: 312 WEVRSTVSGRIYFVDHNNRTTQFTDP 337
WE R GR+Y+VDH + T + P
Sbjct: 291 WEQRVDQHGRVYYVDHVEKRTTWDRP 316
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 459 bits (1182), Expect = e-129
Identities = 242/554 (43%), Positives = 338/554 (61%), Gaps = 47/554 (8%)
Query: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP---------SPSGTIPGGDAAFLYEFL 286
LP G+E+RT +G+ Y++ T +TW P S + G F FL
Sbjct: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
Query: 287 LQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPR-------- 338
Q ++ S + D LGPLPPGWE R +GR+Y+V+HN RTTQ+ DPR
Sbjct: 392 YQSSSA------STDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEP 444
Query: 339 --------------LHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKV 384
+ + ++H + P P G+ + R R + +
Sbjct: 445 ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRF 504
Query: 385 LRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVA 444
L H +L H +I VSR+ +FE+S++QIM M+P DL++RL + RGEEGLDYGG+A
Sbjct: 505 LCHSNALPS----HVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIA 560
Query: 445 REWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGH 504
REW +LL HE+LNP Y LF+Y+ N Y LQINP SSINPDHL+YF F+GR + +A++HG
Sbjct: 561 REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK 620
Query: 505 YINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFG 563
+I+ GFT+PFYK++L K L DLES+DPE + S+VWI EN++ L+ F + G
Sbjct: 621 FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILG 680
Query: 564 RILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPF 623
++ HELK G ++ VTEENK+EY+ L +WRF RG+E Q A GFNE+ P L+ F
Sbjct: 681 KVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYF 740
Query: 624 DQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTG 683
D+KELEL++ G+ +ID++DW+ +T +H +S ++WFWQ V+ D E+R RLLQFVTG
Sbjct: 741 DEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG 800
Query: 684 STRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEK 743
+ R+P+ GF L GS GP+ F I + T LP++HTCFNR+D+PPY+SYE+L EK
Sbjct: 801 TCRLPVGGFAELIGSN---GPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREK 856
Query: 744 LLTAVEETCGFAVE 757
LL A+EET GF E
Sbjct: 857 LLYAIEETEGFGQE 870
Score = 61.2 bits (147), Expect = 3e-09
Identities = 52/191 (27%), Positives = 71/191 (37%), Gaps = 67/191 (35%)
Query: 157 ENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPD 216
E V S P PLS P P T S A A +P++ + P
Sbjct: 246 EEPSVVGVTSPPAAPLSV---TPNPNTTSLPAPA---------TPAEGEE--------PS 285
Query: 217 VRGSLQTPQNRPHGHQSPE-LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIP 275
G+ Q P Q+P+ LP G+EQR G+VY++ T +TW P
Sbjct: 286 TSGTQQLPA----AAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP---------- 331
Query: 276 GGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFT 335
LPPGWE R+ GR Y+VDHN RTT +
Sbjct: 332 --------------------------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQ 359
Query: 336 DPRLHHIMNHQ 346
P ++ N++
Sbjct: 360 RPTAEYVRNYE 370
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/59 (37%), Positives = 30/59 (50%)
Query: 232 QSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGH 290
Q P LP G+E + T +G YF+ T +T+ DPR SGT G A+ F + H
Sbjct: 442 QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYH 500
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 411 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 449
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 450 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 486
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 665
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 666 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 725
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 726 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 785
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 786 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 842 MAVENAQGF 850
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 46.6 bits (109), Expect = 9e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 348
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 349 LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
L P+ L P EG+ ++ P +R +D
Sbjct: 326 LSSPTVTLSAPLEGA---KDSPVRRAVKD 351
Score = 31.2 bits (69), Expect = 3.7
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
H SE DL E G +P WE S
Sbjct: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 452 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 511
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 512 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 550
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 551 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 587
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 588 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 647
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 648 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 707
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 708 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 766
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 767 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 826
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 827 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 886
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 887 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 942
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 943 MAVENAQGF 951
Score = 61.2 bits (147), Expect = 3e-09
Identities = 104/464 (22%), Positives = 172/464 (37%), Gaps = 124/464 (26%)
Query: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 17 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 76
Query: 65 HYDLYVGKTD-SITISVWNHKKIHKKQGAGFLGCVR----------------------LL 101
+ V ++ + V++ ++ + FLG V LL
Sbjct: 77 EFYFRVNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLL 133
Query: 102 SNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGT 161
+ + G+ RL + + + GQ + RD + G VVD + +
Sbjct: 134 RPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDS----NDSAS 184
Query: 162 VYEDSGPGRPLSCFMEEPAPYTDST-------------------GAAAGGGNCRFVESPS 202
+++ P PL EE T ++ N R + +
Sbjct: 185 QHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEA 244
Query: 203 QDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTW 262
+R +++R + D+ P + ++PE +E T+ +V G++
Sbjct: 245 AHRRFRSRRHISEDL---------EPEPSEGGDVPEPWE---TISEEVNIAGDSLGLALP 292
Query: 263 HDPRIPSPSGTIPGGDAAFL--------------YEFLLQGHTSEPRDLNSVN--CDELG 306
P P S T P + L + L+Q S SV E G
Sbjct: 293 PPPASPG-SRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQG 351
Query: 307 PLPP--------------GWEVRSTVSGRIYFVDHNNRTTQFTDPRL------------- 339
LPP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 352 HLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN 411
Query: 340 --HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 412 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 452
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 331 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 390
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 391 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 429
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 430 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 466
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 467 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 526
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 527 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 586
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 587 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 645
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 646 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 705
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 706 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 765
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 766 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 821
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 822 MAVENAQGF 830
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 47.0 bits (110), Expect = 7e-05
Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 27/110 (24%)
Query: 288 QGHTSEPRDLNSVNCDELGP-LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL------- 339
QGH P SV P LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 229 QGHLPPP----SVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGA 284
Query: 340 --------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 285 SGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 331
Score = 31.2 bits (69), Expect = 3.7
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
H SE DL E G +P WE S
Sbjct: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 331 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 390
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 391 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 429
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 430 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 466
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 467 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 526
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 527 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 586
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 587 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 645
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 646 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 705
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 706 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 765
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 766 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 821
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 822 MAVENAQGF 830
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 47.0 bits (110), Expect = 7e-05
Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 27/110 (24%)
Query: 288 QGHTSEPRDLNSVNCDELGP-LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL------- 339
QGH P SV P LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 229 QGHLPPP----SVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGA 284
Query: 340 --------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 285 SGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 331
Score = 31.2 bits (69), Expect = 3.7
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
H SE DL E G +P WE S
Sbjct: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 444 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 503
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 504 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 542
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 543 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 579
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 580 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 639
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 640 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 699
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 700 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 758
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 759 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 818
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 819 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 878
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 879 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 934
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 935 MAVENAQGF 943
Score = 61.2 bits (147), Expect = 3e-09
Identities = 104/464 (22%), Positives = 172/464 (37%), Gaps = 124/464 (26%)
Query: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 9 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 68
Query: 65 HYDLYVGKTD-SITISVWNHKKIHKKQGAGFLGCVR----------------------LL 101
+ V ++ + V++ ++ + FLG V LL
Sbjct: 69 EFYFRVNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLL 125
Query: 102 SNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGT 161
+ + G+ RL + + + GQ + RD + G VVD + +
Sbjct: 126 RPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDS----NDSAS 176
Query: 162 VYEDSGPGRPLSCFMEEPAPYTDST-------------------GAAAGGGNCRFVESPS 202
+++ P PL EE T ++ N R + +
Sbjct: 177 QHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEA 236
Query: 203 QDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTW 262
+R +++R + D+ P + ++PE +E T+ +V G++
Sbjct: 237 AHRRFRSRRHISEDL---------EPEPSEGGDVPEPWE---TISEEVNIAGDSLGLALP 284
Query: 263 HDPRIPSPSGTIPGGDAAFL--------------YEFLLQGHTSEPRDLNSVN--CDELG 306
P P S T P + L + L+Q S SV E G
Sbjct: 285 PPPASPG-SRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQG 343
Query: 307 PLPP--------------GWEVRSTVSGRIYFVDHNNRTTQFTDPRL------------- 339
LPP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 344 HLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN 403
Query: 340 --HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 404 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 444
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 464 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 523
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 524 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 562
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 563 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 599
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 600 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 659
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 660 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 719
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 720 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 778
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 779 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 838
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 839 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 898
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 899 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 954
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 955 MAVENAQGF 963
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
Score = 46.6 bits (109), Expect = 9e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 348
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 438
Query: 349 LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
L P+ L P EG+ ++ P +R +D
Sbjct: 439 LSSPTVTLSAPLEGA---KDSPVRRAVKD 464
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 5/62 (8%)
Query: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 9 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 68
Query: 65 HY 66
+
Sbjct: 69 EF 70
Score = 31.2 bits (69), Expect = 3.7
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 185 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 244
Query: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
H SE DL E G +P WE S
Sbjct: 245 RHISE--DLEP-EPSEGGDVPEPWETIS 269
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 472 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 531
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 532 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 570
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 571 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 607
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 608 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 667
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 668 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 727
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 728 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 786
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 787 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 846
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 847 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 906
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 907 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 962
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 963 MAVENAQGF 971
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
Score = 46.6 bits (109), Expect = 9e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 348
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 446
Query: 349 LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
L P+ L P EG+ ++ P +R +D
Sbjct: 447 LSSPTVTLSAPLEGA---KDSPVRRAVKD 472
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 5/62 (8%)
Query: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 17 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 76
Query: 65 HY 66
+
Sbjct: 77 EF 78
Score = 31.2 bits (69), Expect = 3.7
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 193 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 252
Query: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
H SE DL E G +P WE S
Sbjct: 253 RHISE--DLEP-EPSEGGDVPEPWETIS 277
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 411 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 449
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 450 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 486
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 665
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 666 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 725
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 726 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 785
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 786 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 842 MAVENAQGF 850
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 46.6 bits (109), Expect = 9e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 348
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 349 LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
L P+ L P EG+ ++ P +R +D
Sbjct: 326 LSSPTVTLSAPLEGA---KDSPVRRAVKD 351
Score = 31.2 bits (69), Expect = 3.7
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
H SE DL E G +P WE S
Sbjct: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 411 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 449
Query: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 450 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 486
Query: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
Query: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
Query: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 665
Query: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 666 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 725
Query: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 726 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 785
Query: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 786 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
Query: 746 TAVEETCGF 754
AVE GF
Sbjct: 842 MAVENAQGF 850
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 46.6 bits (109), Expect = 9e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 348
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 349 LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
L P+ L P EG+ ++ P +R +D
Sbjct: 326 LSSPTVTLSAPLEGA---KDSPVRRAVKD 351
Score = 31.2 bits (69), Expect = 3.7
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
H SE DL E G +P WE S
Sbjct: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 448 bits (1153), Expect = e-126
Identities = 237/522 (45%), Positives = 330/522 (63%), Gaps = 51/522 (9%)
Query: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPR 295
LP+G+E R G+ +F+ T +TW DPR+ P+ L+G TS
Sbjct: 423 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAH--------------LRGKTS--- 465
Query: 296 DLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQP 355
L++ N +LGPLPPGWE R+ GRI++++HN + TQ+ DPRL ++ + P+ P
Sbjct: 466 -LDTSN--DLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVA-----ITGPAVP 517
Query: 356 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ 415
Y RD +K + R +L Q +++ R + E+SYR+
Sbjct: 518 ------------------YSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRR 559
Query: 416 IMKMRPKD-LKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQ 474
IM ++ D LK RL ++F GE+GLDYGGVAREW +L+ EM NPYYGLF+YS + Y LQ
Sbjct: 560 IMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQ 619
Query: 475 INPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDP 533
INP+S + N DHLSYF F+GR+ G+AV+HG ++G F PFYK +L KPI L D+ESVD
Sbjct: 620 INPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDS 679
Query: 534 ELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 593
E + SL WILEND T LD F ++ FG+ QHELK G + VT +NKKEY+ L +
Sbjct: 680 EYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 738
Query: 594 WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-C 652
WRF+ I+ Q A ++GF ELIPQ L+K FD+ ELEL++ GL +D+NDW+ +T+ K+
Sbjct: 739 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGY 798
Query: 653 VADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLI 712
A+ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+ FT+
Sbjct: 799 SANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQSFTVEQW 855
Query: 713 DANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754
+ LP+AHTCFNR+D+PPYES+E+L++KL A+E T GF
Sbjct: 856 -GTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/34 (52%), Positives = 23/34 (67%)
Query: 304 ELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 337
E PLPPGWE R + GR Y+V+H +R TQ+ P
Sbjct: 189 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 222
Score = 38.5 bits (88), Expect = 0.023
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 4/54 (7%)
Query: 15 IRLTVLCAKNLAKKDFFRLPDPFAKIVV----DGSGQCHSTDTVKNTLDPKWNQ 64
+R+ V+ LAKKD DP+ ++ + +G T T+K +L+PKWN+
Sbjct: 21 VRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNE 74
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 448 bits (1153), Expect = e-126
Identities = 237/522 (45%), Positives = 330/522 (63%), Gaps = 51/522 (9%)
Query: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPR 295
LP+G+E R G+ +F+ T +TW DPR+ P+ L+G TS
Sbjct: 770 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAH--------------LRGKTS--- 812
Query: 296 DLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQP 355
L++ N +LGPLPPGWE R+ GRI++++HN + TQ+ DPRL ++ + P+ P
Sbjct: 813 -LDTSN--DLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVA-----ITGPAVP 864
Query: 356 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ 415
Y RD +K + R +L Q +++ R + E+SYR+
Sbjct: 865 ------------------YSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRR 906
Query: 416 IMKMRPKD-LKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQ 474
IM ++ D LK RL ++F GE+GLDYGGVAREW +L+ EM NPYYGLF+YS + Y LQ
Sbjct: 907 IMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQ 966
Query: 475 INPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDP 533
INP+S + N DHLSYF F+GR+ G+AV+HG ++G F PFYK +L KPI L D+ESVD
Sbjct: 967 INPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDS 1026
Query: 534 ELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 593
E + SL WILEND T LD F ++ FG+ QHELK G + VT +NKKEY+ L +
Sbjct: 1027 EYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 1085
Query: 594 WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-C 652
WRF+ I+ Q A ++GF ELIPQ L+K FD+ ELEL++ GL +D+NDW+ +T+ K+
Sbjct: 1086 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGY 1145
Query: 653 VADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLI 712
A+ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+ FT+
Sbjct: 1146 SANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQSFTVEQW 1202
Query: 713 DANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754
+ LP+AHTCFNR+D+PPYES+E+L++KL A+E T GF
Sbjct: 1203 -GTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/34 (52%), Positives = 23/34 (67%)
Query: 304 ELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 337
E PLPPGWE R + GR Y+V+H +R TQ+ P
Sbjct: 536 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 447 bits (1150), Expect = e-125
Identities = 239/557 (42%), Positives = 331/557 (59%), Gaps = 52/557 (9%)
Query: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFL 286
LP G+E+R + +VY++ T +TW P + S + G F +L
Sbjct: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYL 442
Query: 287 LQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 346
+ + D GPLPPGWE R + R+YFV+HN +TTQ+ DPR + N +
Sbjct: 443 YSA------SMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE 496
Query: 347 -------------------------CQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQK 381
K+P ++G P YER K
Sbjct: 497 PLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGG------PQIAYERGFRWK 550
Query: 382 LKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYG 441
L R+ L H +I VSR+ +FE+S++QIM ++P DL++RL V FRGEEGLDYG
Sbjct: 551 LAHFRY-LCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYG 609
Query: 442 GVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVF 501
G+AREW +LL HE+LNP Y LF+Y+ N Y LQINP S+INPDHLSYF F+GR + +A+F
Sbjct: 610 GLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALF 669
Query: 502 HGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHN 560
HG +I+ GF++PFYK++L K + + DLES+D E + SL+WI +N+I L+ F V+
Sbjct: 670 HGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDME 729
Query: 561 AFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLL 620
G++ H+LK G N+ VTEENK EY+ L WRF RG++ Q A GFNE++P L
Sbjct: 730 ILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWL 789
Query: 621 KPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQF 680
+ FD+KELE+++ G+ ++DL DW+ NT +H +S + WFWQ V+ D E R RLLQF
Sbjct: 790 QYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQF 849
Query: 681 VTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKL 740
VTG+ R+PL GF L GS GP+ F I + +T LP++HTCFNR+D+PPY+SYE+L
Sbjct: 850 VTGTCRLPLGGFAELMGSN---GPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQL 905
Query: 741 YEKLLTAVEETCGFAVE 757
EKLL A+EET GF E
Sbjct: 906 KEKLLFAIEETEGFGQE 922
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/140 (27%), Positives = 55/140 (39%), Gaps = 44/140 (31%)
Query: 208 QAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR 266
+A + R PD P + G+ + E LP G+EQR G+ Y++ T +TW P+
Sbjct: 325 EAAKSRQPD---GCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
Query: 267 IPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVD 326
PLPPGWE R R+Y+VD
Sbjct: 382 ----------------------------------------PLPPGWERRVDDRRRVYYVD 401
Query: 327 HNNRTTQFTDPRLHHIMNHQ 346
HN RTT + P + + N +
Sbjct: 402 HNTRTTTWQRPTMESVRNFE 421
Score = 48.9 bits (115), Expect = 2e-05
Identities = 82/390 (21%), Positives = 144/390 (36%), Gaps = 76/390 (19%)
Query: 6 TRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQH 65
+ + +++++TV AK KK++F + ++VVDG + T ++ +PKW++
Sbjct: 11 SNNHSGRLQLQVTVSSAKLKRKKNWFGTAI-YTEVVVDG--EITKTAKSSSSSNPKWDEQ 67
Query: 66 YDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSD 125
+ V ++ VW+H+ L LL A LK ++
Sbjct: 68 LTVNVTPQTTLEFQVWSHRT---------LKADALLGKATIDLKQA-------LLIHNRK 111
Query: 126 TDAVRGQIVVSLQTRDRIGTGG--------------SVVDCRG-----LLENEGTVYEDS 166
+ V+ Q+ +SL+ ++ I G ++ +C + EN ++E+
Sbjct: 112 LERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENG 171
Query: 167 GP-GRPLSCFMEEPAPYTDS---TGAAAGGGNCRFV----ESPSQDQRLQAQRLRNPDVR 218
P R + E D+ T C +V +PS ++ A+ P +
Sbjct: 172 EPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPK 231
Query: 219 GSLQTP-QNRPHGHQSPELP--EGYEQRTTVQGQVYFLHTQTGVSTWHDPRI------PS 269
P + +G S P T V + L +T DP +
Sbjct: 232 PLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSE 291
Query: 270 PSGTIPGGDAAFLYE--FLLQGHTSEPRDLNSVNCDE-------LGP------------L 308
+ IP A E +L+ TS R ++ + + P L
Sbjct: 292 NNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETL 351
Query: 309 PPGWEVRSTVSGRIYFVDHNNRTTQFTDPR 338
P GWE R GR Y+VDHN RTT + P+
Sbjct: 352 PSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 430 bits (1106), Expect = e-120
Identities = 218/451 (48%), Positives = 295/451 (65%), Gaps = 27/451 (5%)
Query: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDE 367
LPPGWE++ T G YFVDHN RTT F DPR P G+ +
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR------------------PGFESGTKQGS 48
Query: 368 ELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKR 427
R R + + L H +L H +I VSR+ +FE+S++QIM M+P DL++R
Sbjct: 49 PGAYDRSFRWKYHQFRFLCHSNALPS----HVKISVSRQTLFEDSFQQIMNMKPYDLRRR 104
Query: 428 LMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLS 487
L + RGEEGLDYGG+AREW +LL HE+LNP Y LF+Y+ N Y LQINP SSINPDHL+
Sbjct: 105 LYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLT 164
Query: 488 YFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDI 547
YF F+GR + +A++HG +I+ GFT+PFYK++L K L DLES+DPE + S+VWI EN++
Sbjct: 165 YFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNL 224
Query: 548 TPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLA 606
L+ F + G++ HELK G ++ VTEENK+EY+ L +WRF RG+E Q A
Sbjct: 225 EECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKA 284
Query: 607 LQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAV 666
GFNE+ P L+ FD+KELEL++ G+ +ID++DW+ +T +H +S ++WFWQ V
Sbjct: 285 FLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVV 344
Query: 667 ETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCF 726
+ D E+R RLLQFVTG+ R+P+ GF L GS GP+ F I + T LP++HTCF
Sbjct: 345 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN---GPQKFCIDKVGKET-WLPRSHTCF 400
Query: 727 NRIDIPPYESYEKLYEKLLTAVEETCGFAVE 757
NR+D+PPY+SYE+L EKLL A+EET GF E
Sbjct: 401 NRLDLPPYKSYEQLREKLLYAIEETEGFGQE 431
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/59 (37%), Positives = 30/59 (50%)
Query: 232 QSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGH 290
Q P LP G+E + T +G YF+ T +T+ DPR SGT G A+ F + H
Sbjct: 3 QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYH 61
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 360 bits (925), Expect = 2e-99
Identities = 187/388 (48%), Positives = 255/388 (65%), Gaps = 8/388 (2%)
Query: 374 YERDLVQKLKVLRHELSLQQPQAGHCRIE--VSREEIFEESYRQIMKMRPKDLKK-RLMV 430
Y RD KL+ +L + G +I+ + R+ + E ++ Q+M K+L++ +L V
Sbjct: 1223 YRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYV 1282
Query: 431 KFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFH 490
F GEEGLDY G +RE+ +LL E+ NPYYGLF+YS ++ Y +QI+P S+ +HL +F
Sbjct: 1283 TFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFR 1342
Query: 491 FVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV 550
F GRI+GLA+ H + ++ FT PFYK LL P LSDLE +D E H+SL W+ +N+IT +
Sbjct: 1343 FSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI 1402
Query: 551 LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKG 610
LD TF V FG++ + ELK G N VTE+NKKEY+ V WR RG+ Q AL +G
Sbjct: 1403 LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRG 1462
Query: 611 FNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETF 669
F E++ L+ FD +ELEL+I G +IDLNDW++NT + D + ++RWFW AVE F
Sbjct: 1463 FYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERF 1522
Query: 670 DEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRI 729
+ E+R RLLQFVTG++ VP +GF AL+GS G R F I T +LP+AHTCFNR+
Sbjct: 1523 NNEQRLRLLQFVTGTSSVPYEGFAALRGSNGL---RRFCIEKWGKIT-SLPRAHTCFNRL 1578
Query: 730 DIPPYESYEKLYEKLLTAVEETCGFAVE 757
D+PPY SY LYEKLLTAVEET F +E
Sbjct: 1579 DLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
Score = 46.6 bits (109), Expect = 9e-05
Identities = 23/48 (47%), Positives = 31/48 (64%), Gaps = 3/48 (6%)
Query: 295 RDL-NSVN--CDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
RDL N +N D LP GWE+++ G+ +FVDHN+R T F DPR+
Sbjct: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
Score = 43.1 bits (100), Expect = 0.001
Identities = 17/31 (54%), Positives = 21/31 (67%)
Query: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 337
PLPP WE R GR+++VDH NRTT + P
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 39.7 bits (91), Expect = 0.010
Identities = 17/41 (41%), Positives = 27/41 (65%)
Query: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIP 275
ELP G+E +T QG+ +F+ + +T+ DPRIP +G +P
Sbjct: 1019 ELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLP 1059
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 360 bits (925), Expect = 2e-99
Identities = 192/424 (45%), Positives = 268/424 (63%), Gaps = 11/424 (2%)
Query: 341 HIMNHQCQLKEP-SQPLPLP--SEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQ--PQ 395
H + H + P P+ P S G+ Y+RD KL+ +L +
Sbjct: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQG 1212
Query: 396 AGHCRIEVSREEIFEESYRQIMKMRPKDLKK-RLMVKFRGEEGLDYGGVAREWLYLLCHE 454
G ++ + R+ + E+++ QIM KDL++ +L V F GEEGLDY G +RE+ +L+ E
Sbjct: 1213 PGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE 1272
Query: 455 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 514
+ NPYYGLF+YS ++ Y +QI+P S+ +H +F F GRI+GLA+ H + ++ FT PF
Sbjct: 1273 LFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPF 1332
Query: 515 YKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNG 574
YK LL LSDLE +D E H+SL W+ +NDI +LD TF V FG+I + ELKP G
Sbjct: 1333 YKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGG 1392
Query: 575 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG 634
N+PVTE+NKKEY+ V WR RG+ Q +L +GF E++ L+ FD +ELEL+I G
Sbjct: 1393 ANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAG 1452
Query: 635 LDKIDLNDWKSNTRLKHCVADSNIV-RWFWQAVETFDEERRARLLQFVTGSTRVPLQGFK 693
+IDL+DW++NT + D++IV RWFW AVE F+ E+R RLLQFVTG++ +P +GF
Sbjct: 1453 TAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFA 1512
Query: 694 ALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCG 753
+L+GS GPR F + T LP+AHTCFNR+D+PPY S+ LYEKLLTAVEET
Sbjct: 1513 SLRGSN---GPRRFCVEKWGKIT-ALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETST 1568
Query: 754 FAVE 757
F +E
Sbjct: 1569 FGLE 1572
Score = 47.4 bits (111), Expect = 5e-05
Identities = 19/32 (59%), Positives = 24/32 (75%)
Query: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
LP GWE++ G+ +FVDHN+RTT F DPRL
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Score = 43.5 bits (101), Expect = 7e-04
Identities = 29/100 (29%), Positives = 44/100 (44%), Gaps = 20/100 (20%)
Query: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDE 367
LPP WE R GRI++VDH NRTT + P P P L S++
Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP------------TAPPAPQVLQRSNSIQQM 856
Query: 368 ELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREE 407
E +RY+ +R ++ ++P+ I+ + EE
Sbjct: 857 EQLNRRYQS--------IRRTMTNERPEENTNAIDGAGEE 888
Score = 33.5 bits (75), Expect = 0.75
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPS 271
ELP G+E + QG+ +F+ + +T+ DPR+P S
Sbjct: 986 ELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQS 1022
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 330 bits (846), Expect = 3e-90
Identities = 165/351 (47%), Positives = 229/351 (65%), Gaps = 4/351 (1%)
Query: 401 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 460
+ V R+ +FE+SYR++ + P+++K RL + F GEEG D GG+ REW ++ EM NP Y
Sbjct: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
Query: 461 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 520
LF+ S + INP S NP+HLSYF FVGRI+ AV+ + FT FYK +LG
Sbjct: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
Query: 521 KPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPV 579
K ++ +D+ES D ++ LV++LEND++ + D TF E FG +LKPNG N+ V
Sbjct: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
Query: 580 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 639
TEENKKEYV L R I Q A +GF E+IP+ L+ F ++ELEL+I GL ID
Sbjct: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
Query: 640 LNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGST 699
++D KSNT ++S ++WFW+A+ +FD+ RA+ LQFVTG+++VPLQGF AL+G
Sbjct: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
Query: 700 GAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 750
G + F IH D +TD LP AHTCFN++D+P YES+EKL LL A++E
Sbjct: 4319 GI---QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQE 4366
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 272 bits (695), Expect = 1e-72
Identities = 149/353 (42%), Positives = 211/353 (59%), Gaps = 9/353 (2%)
Query: 403 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 462
V R+ IF S + K LK+ + V+F GEEG+ G V REW +L +E++NP Y L
Sbjct: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
Query: 463 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 522
F S D Q N +S +NPDHL+YF F G+I+GLA+ H +N FT FYK +LG P
Sbjct: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
Query: 523 IQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTE 581
+ D+ S+DPE K+L WIL+NDI+ + L+ TF VE + FG + + LKP G ++ VT+
Sbjct: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
Query: 582 ENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLN 641
NK EYV+L R R I+ Q A +GF+ IP L++ FD+ ELEL++ G+ +ID++
Sbjct: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
Query: 642 DWKSNTR-LKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTG 700
DW NT + +++WFW+ VE +E R LLQFVTGS+RVP GF + G +G
Sbjct: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
Query: 701 AAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCG 753
FTI + + LP + TC N + +P Y S E L ++LL A+ CG
Sbjct: 855 LQN---FTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH--CG 902
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 197 bits (502), Expect = 2e-50
Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)
Query: 398 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 454
+ R++V R+ I +++ I P DLKK+L V+F GE+G+D GGV++E+ L+ E
Sbjct: 519 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 578
Query: 455 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 514
+ NP G+F Y ++ + NP S + F +G ++GLA+++ ++ F +
Sbjct: 579 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 634
Query: 515 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 571
Y++L+GK DL P L++SL +LE ++ + TF + + FG + ++LK
Sbjct: 635 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 694
Query: 572 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 630
NG +P+T EN+KE+V LY ++ + +E QF A ++GF+ + + LK F +E+EL
Sbjct: 695 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 754
Query: 631 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 689
+I G +D + T DS ++R FW+ V +F +E++ LQF TG+ R P+
Sbjct: 755 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 814
Query: 690 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749
G L+ GP +T+ LP +HTCFN + +P Y S EKL E+LL A+
Sbjct: 815 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 864
Query: 750 ETCGFAV 756
GF +
Sbjct: 865 YAKGFGM 871
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 197 bits (502), Expect = 2e-50
Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)
Query: 398 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 454
+ R++V R+ I +++ I P DLKK+L V+F GE+G+D GGV++E+ L+ E
Sbjct: 499 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 558
Query: 455 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 514
+ NP G+F Y ++ + NP S + F +G ++GLA+++ ++ F +
Sbjct: 559 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 614
Query: 515 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 571
Y++L+GK DL P L++SL +LE ++ + TF + + FG + ++LK
Sbjct: 615 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 674
Query: 572 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 630
NG +P+T EN+KE+V LY ++ + +E QF A ++GF+ + + LK F +E+EL
Sbjct: 675 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 734
Query: 631 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 689
+I G +D + T DS ++R FW+ V +F +E++ LQF TG+ R P+
Sbjct: 735 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 794
Query: 690 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749
G L+ GP +T+ LP +HTCFN + +P Y S EKL E+LL A+
Sbjct: 795 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 844
Query: 750 ETCGFAV 756
GF +
Sbjct: 845 YAKGFGM 851
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 197 bits (502), Expect = 2e-50
Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)
Query: 398 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 454
+ R++V R+ I +++ I P DLKK+L V+F GE+G+D GGV++E+ L+ E
Sbjct: 522 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 581
Query: 455 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 514
+ NP G+F Y ++ + NP S + F +G ++GLA+++ ++ F +
Sbjct: 582 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 637
Query: 515 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 571
Y++L+GK DL P L++SL +LE ++ + TF + + FG + ++LK
Sbjct: 638 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 697
Query: 572 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 630
NG +P+T EN+KE+V LY ++ + +E QF A ++GF+ + + LK F +E+EL
Sbjct: 698 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 757
Query: 631 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 689
+I G +D + T DS ++R FW+ V +F +E++ LQF TG+ R P+
Sbjct: 758 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 817
Query: 690 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749
G L+ GP +T+ LP +HTCFN + +P Y S EKL E+LL A+
Sbjct: 818 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 867
Query: 750 ETCGFAV 756
GF +
Sbjct: 868 YAKGFGM 874
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 192 bits (488), Expect = 1e-48
Identities = 122/373 (32%), Positives = 192/373 (51%), Gaps = 31/373 (8%)
Query: 401 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 460
++V R + +S ++ + R DLKK+L V F GE GLD GG+ +EW LL ++ +P Y
Sbjct: 419 MKVRRTHLVSDSLDELTRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDY 477
Query: 461 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 520
G+F Y D+ + SS D+ S F VG +MGLAV++ ++ F YK+LL
Sbjct: 478 GMFTYHKDS----HCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLS 533
Query: 521 KPI--------------QLSDLESVDPELHKSLVWIL--ENDITPVLDHTFCVEHNAFGR 564
PI + DL + PEL L +L E ++ TF V FG
Sbjct: 534 PPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGI 593
Query: 565 ILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFD 624
I + LKP G + VT +N+KEYV+LY ++ + I QF A GF+ + + L
Sbjct: 594 IKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLR 653
Query: 625 QKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGS 684
+E+E+++ G +D++ + +T+ +++FW V F + + +LL F TGS
Sbjct: 654 PEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGS 713
Query: 685 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKL 744
RVP+ G L F I + +T+ LP AHTCFN++ +PPY+S + L +KL
Sbjct: 714 DRVPVGGMADLN----------FKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
Query: 745 LTAVEETCGFAVE 757
+ + + GF +E
Sbjct: 764 IIGISNSEGFGLE 776
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 187 bits (476), Expect = 2e-47
Identities = 133/400 (33%), Positives = 204/400 (51%), Gaps = 43/400 (10%)
Query: 381 KLKVLRHELSLQQPQAGHCRI--EVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGL 438
K+ + EL + H ++ +VSR + E S + D K V F+ EE L
Sbjct: 442 KVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEAL 501
Query: 439 DYGGVAREWLYLLCHEMLNPYYGLF-QYSTDNIYMLQINPDSSINPDHL--SYFHFVGRI 495
D+GG REW L+C + + LF ++S +N ++ NP+ P HL + F GR+
Sbjct: 502 DWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFAGRL 558
Query: 496 MGLAVFH----GHY---INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV-WILENDI 547
+G ++ G Y + FT F Q++G + E+ DPE +KS V +IL ND+
Sbjct: 559 VGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDM 618
Query: 548 TPVLDHTFCVE-HNAFGRILQH-ELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFL 605
+ ++ F E +N G++ + EL G PVT NK Y+ L +R ++ +
Sbjct: 619 SE-MELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVE 677
Query: 606 ALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVA-------DSNI 658
KG NEL+P++LL FD+ ELEL++ G I ++D+K+ H V +
Sbjct: 678 HFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKA-----HAVVVGGSWHFREKV 732
Query: 659 VRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANT-D 717
+RWFW V + +E ARLLQF TGS+++P GF AL S +I A T
Sbjct: 733 MRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS----------FQIIAAPTHS 782
Query: 718 NLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETC-GFAV 756
LP AHTCFN++ +P Y+SYE+++ L A+ E C GF +
Sbjct: 783 TLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGM 822
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 176 bits (447), Expect = 5e-44
Identities = 121/382 (31%), Positives = 194/382 (50%), Gaps = 24/382 (6%)
Query: 386 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG-----EEGLDY 440
+ E+ P + + R I+E++Y ++ DLKKR+ V E G+D
Sbjct: 710 KQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDG 769
Query: 441 GGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS--INPDHLSYFHFVGRIMGL 498
GG+ RE+L L NP G F+ T N +L NP + + +++F+GR++G
Sbjct: 770 GGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGK 827
Query: 499 AVFHGHYINGGFTVPFYKQLLGKP--IQLSDLESVDPELHKSLVWI--LENDITPVLDHT 554
A++ + F F +LLG + + L S+DPE++K+L+++ E+D+ L
Sbjct: 828 ALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE-LGLN 886
Query: 555 FCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNEL 614
F V +N G ELK G+++PVT N+ Y+ L ++R R I LA ++G +
Sbjct: 887 FTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANV 946
Query: 615 IPQHLLKPFDQKELELIIGGLD-KIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEE 672
+ L+ FDQ+E++++I G I L D KS T AD +++ FW+ VE F +E
Sbjct: 947 VSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDE 1006
Query: 673 RRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 732
+ +LL+FVT +R PL GFK L + F IH ++ + LP A TC N + +P
Sbjct: 1007 EKRKLLKFVTSCSRPPLLGFKELYPA--------FCIHNGGSDLERLPTASTCMNLLKLP 1058
Query: 733 PYESYEKLYEKLLTAVEETCGF 754
+ L KLL A+E GF
Sbjct: 1059 EFYDETLLRSKLLYAIECAAGF 1080
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 176 bits (446), Expect = 7e-44
Identities = 111/358 (31%), Positives = 184/358 (51%), Gaps = 18/358 (5%)
Query: 403 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 462
V RE I ++ + K + D KK L V F GE+ +D GGV +E+ L+ E+L+P YG+
Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
Query: 463 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 522
F+Y D+ L D + L FH +G I GLA+++ ++ F + YK+LL K
Sbjct: 765 FRYYEDS--RLIWFSDKTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
Query: 523 IQLSDLESVDPELHKSLVWIL---ENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPV 579
L DL+ + P++ +S+ +L E+DI F + FG EL NG + V
Sbjct: 821 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 880
Query: 580 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 639
++N++E+V YV++ F + + + F A GF+++ +L F EL+ ++ G D
Sbjct: 881 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 940
Query: 640 LNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 698
+ + NT K A+ ++ FW+ E++ + L F+TGS R+P+ G K+L+
Sbjct: 941 WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 998
Query: 699 TGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 756
I + LP +HTCFN +D+P Y E L KL+ A++ GF++
Sbjct: 999 --------LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 176 bits (446), Expect = 7e-44
Identities = 111/358 (31%), Positives = 184/358 (51%), Gaps = 18/358 (5%)
Query: 403 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 462
V RE I ++ + K + D KK L V F GE+ +D GGV +E+ L+ E+L+P YG+
Sbjct: 713 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 772
Query: 463 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 522
F+Y D+ L D + L FH +G I GLA+++ ++ F + YK+LL K
Sbjct: 773 FRYYEDS--RLIWFSDKTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 828
Query: 523 IQLSDLESVDPELHKSLVWIL---ENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPV 579
L DL+ + P++ +S+ +L E+DI F + FG EL NG + V
Sbjct: 829 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 888
Query: 580 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 639
++N++E+V YV++ F + + + F A GF+++ +L F EL+ ++ G D
Sbjct: 889 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 948
Query: 640 LNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 698
+ + NT K A+ ++ FW+ E++ + L F+TGS R+P+ G K+L+
Sbjct: 949 WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 1006
Query: 699 TGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 756
I + LP +HTCFN +D+P Y E L KL+ A++ GF++
Sbjct: 1007 --------LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,881,150
Number of Sequences: 37866
Number of extensions: 1668523
Number of successful extensions: 4666
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 4114
Number of HSP's gapped (non-prelim): 366
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.