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Search of human proteins with 30089962
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
(1719 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 3438 0.0
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 2976 0.0
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 2106 0.0
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 1311 0.0
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 521 e-147
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 521 e-147
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 516 e-146
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 478 e-134
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 476 e-133
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 464 e-130
gi|32698688 citron [Homo sapiens] 404 e-112
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 308 2e-83
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 212 2e-54
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 209 2e-53
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 209 2e-53
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 206 1e-52
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 206 1e-52
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 206 1e-52
gi|4885563 protein kinase C, epsilon [Homo sapiens] 206 2e-52
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 206 2e-52
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 206 2e-52
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 205 4e-52
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 204 6e-52
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 204 6e-52
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 204 6e-52
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 204 6e-52
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 204 6e-52
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 204 8e-52
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 203 1e-51
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 202 2e-51
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 3438 bits (8914), Expect = 0.0
Identities = 1719/1719 (100%), Positives = 1719/1719 (100%)
Query: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA
Sbjct: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
Query: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA
Sbjct: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
Sbjct: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT
Sbjct: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
Query: 241 PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER
Sbjct: 241 PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
Query: 301 FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
Sbjct: 301 FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
Query: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA
Sbjct: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
Query: 421 GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP
Sbjct: 421 GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
Query: 481 LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540
LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
Sbjct: 481 LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540
Query: 541 QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV 600
QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV
Sbjct: 541 QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV 600
Query: 601 RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLE 660
RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLE
Sbjct: 601 RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLE 660
Query: 661 NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK 720
NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
Sbjct: 661 NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK 720
Query: 721 ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT 780
ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT
Sbjct: 721 ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT 780
Query: 781 SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA 840
SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA
Sbjct: 781 SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA 840
Query: 841 LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL 900
LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
Sbjct: 841 LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL 900
Query: 901 NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTP 960
NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTP
Sbjct: 901 NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTP 960
Query: 961 TDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLM 1020
TDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLM
Sbjct: 961 TDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLM 1020
Query: 1021 VGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPK 1080
VGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPK
Sbjct: 1021 VGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPK 1080
Query: 1081 PAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIH 1140
PAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIH
Sbjct: 1081 PAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIH 1140
Query: 1141 ASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSV 1200
ASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSV
Sbjct: 1141 ASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSV 1200
Query: 1201 YVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIEL 1260
YVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIEL
Sbjct: 1201 YVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIEL 1260
Query: 1261 IPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVA 1320
IPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVA
Sbjct: 1261 IPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVA 1320
Query: 1321 MKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYS 1380
MKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYS
Sbjct: 1321 MKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYS 1380
Query: 1381 MLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPS 1440
MLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPS
Sbjct: 1381 MLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPS 1440
Query: 1441 SCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKN 1500
SCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKN
Sbjct: 1441 SCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKN 1500
Query: 1501 KMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISN 1560
KMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISN
Sbjct: 1501 KMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISN 1560
Query: 1561 PTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSG 1620
PTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSG
Sbjct: 1561 PTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSG 1620
Query: 1621 LSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDS 1680
LSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDS
Sbjct: 1621 LSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDS 1680
Query: 1681 PRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP 1719
PRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP
Sbjct: 1681 PRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP 1719
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 2976 bits (7715), Expect = 0.0
Identities = 1529/1722 (88%), Positives = 1554/1722 (90%), Gaps = 87/1722 (5%)
Query: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA
Sbjct: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
Query: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA
Sbjct: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
Sbjct: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT
Sbjct: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
Query: 241 PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER
Sbjct: 241 PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
Query: 301 FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
Sbjct: 301 FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
Query: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA
Sbjct: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
Query: 421 GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP
Sbjct: 421 GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
Query: 481 LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540
LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
Sbjct: 481 LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540
Query: 541 QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARH- 599
QQEREDLNK V SK+ RKL Q + EL KQK +
Sbjct: 541 QQEREDLNKLEVHTEALAAEASKD-------RKLREQSEHYSKQLENELEGLKQKQISYS 593
Query: 600 --VRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSK 657
V E + ++ K + ++ + E K +H + K
Sbjct: 594 PGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEI------------------K 635
Query: 658 QLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKN 717
L+ EL + +Q++ + +EI LK LEK ++RE
Sbjct: 636 NLKKELHDSEGQQLALN---------KEIMILKDKLEK---------TRRE-------SQ 670
Query: 718 LKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENK 777
++E +SE +Q Q ERE K E LT E
Sbjct: 671 SEREEFESEFKQ---------------------QYERE------KVLLTEENKKLTSELD 703
Query: 778 KLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGY 837
KL TTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGY
Sbjct: 704 KL-------TTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGY 756
Query: 838 LQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQ 897
LQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQ
Sbjct: 757 LQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQ 816
Query: 898 EELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFL 957
EELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFL
Sbjct: 817 EELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFL 876
Query: 958 NTPTDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCT 1017
NTPTDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCT
Sbjct: 877 NTPTDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCT 936
Query: 1018 SLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVR 1077
SLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVR
Sbjct: 937 SLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVR 996
Query: 1078 IPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASD 1137
IPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASD
Sbjct: 997 IPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASD 1056
Query: 1138 VIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRD 1197
VIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRD
Sbjct: 1057 VIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRD 1116
Query: 1198 RSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQ 1257
RSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQ
Sbjct: 1117 RSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQ 1176
Query: 1258 IELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCL 1317
IELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCL
Sbjct: 1177 IELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCL 1236
Query: 1318 CVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGN 1377
CVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGN
Sbjct: 1237 CVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGN 1296
Query: 1378 PYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPA 1437
PYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPA
Sbjct: 1297 PYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPA 1356
Query: 1438 NPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIY 1497
NPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIY
Sbjct: 1357 NPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIY 1416
Query: 1498 FKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKL 1557
FKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKL
Sbjct: 1417 FKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKL 1476
Query: 1558 ISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSA 1617
ISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSA
Sbjct: 1477 ISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSA 1536
Query: 1618 SSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGED 1677
SSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGED
Sbjct: 1537 SSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGED 1596
Query: 1678 SDSPRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP 1719
SDSPRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP
Sbjct: 1597 SDSPRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP 1638
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 2106 bits (5456), Expect = 0.0
Identities = 1061/1749 (60%), Positives = 1347/1749 (77%), Gaps = 70/1749 (4%)
Query: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
MS +VRL++LEQ +LDGP + N SVETLLD+L+CLY EC++S LRR+K + E+LEWA
Sbjct: 1 MSAKVRLKKLEQLLLDGPWR-NESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWA 59
Query: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
KPFT VK+M+LHREDFEI+KVIGRGAFGEVAVVK+KN ++++AMKILNKWEMLKRAETA
Sbjct: 60 KPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETA 119
Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
CFREERDVLVNGD +WIT LHYAFQD+N+LYLVMDYYVGGDLLTLLSKFED+LPEDMARF
Sbjct: 120 CFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARF 179
Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
Y+ EMV+AIDS+HQLHYVHRDIKPDN+L+D+NGHIRLADFGSCLK+ +DGTVQSSVAVGT
Sbjct: 180 YIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGT 239
Query: 241 PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
PDYISPEILQAMEDG G+YGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH+ER
Sbjct: 240 PDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEER 299
Query: 301 FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
FQFP+ VTDVSE AKDLI+RLICSRE RLGQNGIEDFKKH FF G++W+NIRN EAPYIP
Sbjct: 300 FQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIP 359
Query: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
+VSSP+DTSNFDVDDD L+N+E +PP +HT FSG HLPF+GFT+T+ SDR L+
Sbjct: 360 DVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIM 419
Query: 421 GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
+L D +VQR L+++L EAYERRI+RLEQEKLELSRKLQESTQTVQ+L S+
Sbjct: 420 QSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSS-RAL 478
Query: 481 LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540
+++D EIK L EEIE+L+ ++ +S+ LE+QLE+ A+RQE +D+ ++++ EKQ + +
Sbjct: 479 SNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVV 538
Query: 541 QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV 600
+QE+E+L+K+LV+ASERLK+Q+KELKDAH QRKLA+QEF E+NER+ EL QKQK++R +
Sbjct: 539 RQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQL 598
Query: 601 RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLE 660
RDKEEE+++ QKV+++RQE+RR E+ +KELE + AEASK+RKLRE SE++ KQ+E
Sbjct: 599 RDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQME 658
Query: 661 NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK 720
+ELE LK KQ G ++EHQQEI+K+K++LEKK +FYEEEL +RE H E+KN+KK
Sbjct: 659 SELEALKVKQGGRGAG-ATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKK 717
Query: 721 ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT 780
E+HDSE QLAL KEI++LKDKLEK++RE +E EE K +YERE+ +L +ENKKLT
Sbjct: 718 EVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLT 777
Query: 781 SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA 840
+E +KL + + L+ N+QLE+E++DLA KKESVAHWEAQI EIIQWVSDEKDARGYLQA
Sbjct: 778 AENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQA 837
Query: 841 LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL 900
LASKMTEELEALR+SSLG+R D WK+RR KLDMSARLELQSAL+AEIRAKQ +QEEL
Sbjct: 838 LASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEEL 897
Query: 901 NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEE-LRSEKGIEHQDSQHSFLAFLNT 959
KVK +N+ E KLKDSE KN ELL E+E L K EE R++ G++ D Q S + NT
Sbjct: 898 RKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNT 957
Query: 960 PTDALD-QFETVDSTPLSVHTP------------------TLRKKGCPGSTGFP------ 994
A D F T ++ P R P + P
Sbjct: 958 APLAHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALA 1017
Query: 995 ---PKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPV 1051
PK K HQF +KSF++PT+C CTSLMVGLIRQG +CEVC F+CH++C + AP CP+
Sbjct: 1018 LAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPI 1077
Query: 1052 PPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKAS 1111
PPEQ+K PLG+D Q+GIGTAY+GHV++PKP GVKKGWQRA A+VCD KLFLYD+ EGK++
Sbjct: 1078 PPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKST 1137
Query: 1112 QPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLAD 1171
QP V+ SQV+D+RD+EFSVSSVLASDVIHA+R+DIPCIFRVTAS L A + S+L+L +
Sbjct: 1138 QPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTE 1197
Query: 1172 TENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALG 1231
ENEK KWVG+L L IL KN+ R++ V+VP EAYDS+LPLIK AAI+D +RIA+G
Sbjct: 1198 NENEKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVG 1257
Query: 1232 NEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETD 1291
EEGL+V+ VT+D I+R D KK+HQIEL P +++V ++ GRN HV L+P S+LDG E
Sbjct: 1258 LEEGLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGS 1317
Query: 1292 F-YKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQ 1350
F KL ETKGCQ + + ++ + TCL VA+KR +LCYE+ ++K HRKF EI P +VQ
Sbjct: 1318 FDIKLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQ 1377
Query: 1351 WMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEY 1410
+A+ ++LCVG+ SGF + G+G P ++++ ND +L+F++ Q DA+CAVE+ S+EY
Sbjct: 1378 CLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEY 1437
Query: 1411 LLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQT 1470
LLCF+ +G+Y D QGRR+R QELMWPA P +C + +++VYSE VD+FDV +MEW+QT
Sbjct: 1438 LLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQT 1497
Query: 1471 LPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRR 1530
+ L+++RPLN+EG+LNLL E RLIYFK+K + G L VP+TSDNS+KQM+R +KRR
Sbjct: 1498 IGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFS-GAVLNVPDTSDNSKKQMLRT-RSKRR 1555
Query: 1531 YSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQE 1590
+ F+VPEEER+QQRREMLRDPE+R+K+ISNPTNFNH+AHMGPGDG+Q+L DLP++
Sbjct: 1556 FVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLS----- 1610
Query: 1591 SRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMP 1650
++P + RP P A + L+ + ++N + SGGS + P+
Sbjct: 1611 ---------AVPPSQEERPGP-----APTNLARQPPSRNKPYISWPSSGGSEPSVTVPLR 1656
Query: 1651 SPSEGSLSSGGMDQGSDAPARDFDGE-DSDSPRHSTASNSSNLSSPPSPASPRKTKSLSL 1709
S S+ P +DFD E DSDS +HST SNSSN S PPSP SP +++ L L
Sbjct: 1657 SMSD--------------PDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQ-LPL 1701
Query: 1710 ESTDRGSWD 1718
E ++ + D
Sbjct: 1702 EGLEQPACD 1710
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 1311 bits (3392), Expect = 0.0
Identities = 749/1696 (44%), Positives = 1025/1696 (60%), Gaps = 198/1696 (11%)
Query: 4 EVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPF 63
E RLR LEQ + G A G C ++ LLD+L+ L+ E ++ PLRRE+++ ++L WA PF
Sbjct: 2 ERRLRALEQ-LARGEA---GGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPF 57
Query: 64 TSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFR 123
SKVK++RL R+DFEILKVIGRGAFGEV VV+ ++ ++FAMK+L+KWEMLKRAETACFR
Sbjct: 58 VSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFR 117
Query: 124 EERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLA 183
EERDVLV GD++W+TTLHYAFQD+ LYLVMDYY GGDLLTLLS+FEDRLP ++A+FYLA
Sbjct: 118 EERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLA 177
Query: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 243
EMV+AI S+HQL YVHRD+KPDN+L+D+NGHIRLADFGSCL+L +G V SSVAVGTPDY
Sbjct: 178 EMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDY 237
Query: 244 ISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQF 303
ISPEILQAME+GKG YGP+CDWWSLGVC YE+L+GETPFYAESLVETYGKIMNH++ QF
Sbjct: 238 ISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQF 297
Query: 304 PAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVS 363
P V DV +A+DLIR+L+C +E RLG+ G++DF+ HPFF G+DW+ + + APYIPE+
Sbjct: 298 PPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELR 357
Query: 364 SPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPT 423
P DTSNFDVDDD L + T+PPP+H AFSGHHLPFVGFTYTS + P
Sbjct: 358 GPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSG-----------SHSPE 406
Query: 424 SLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTA 483
S ++ A A ER+++ LEQEK+ELSRK QE+ L A
Sbjct: 407 S------------SSEAWAALERKLQCLEQEKVELSRKHQEA---------------LHA 439
Query: 484 SKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQE 543
D E+E+LRK+V L +L E + L Q L+QE
Sbjct: 440 PTD------HRELEQLRKEV---QTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQE 490
Query: 544 REDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDK 603
+ L++EL + L+ Q +EL A Q++ +Q E ER E T Q
Sbjct: 491 LDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQER--EAATASQ--------- 539
Query: 604 EEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASK-----DRKLREQSEHYSKQ 658
+L +L A++ELE +L+ + ++ +++L E S+ +
Sbjct: 540 ----------TRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIH 589
Query: 659 LENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNL 718
+E G+ + G + ++E+ L+ LE
Sbjct: 590 TASETNGMGPPE----GGPQEAQLRKEVAALREQLE------------------------ 621
Query: 719 KKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKK 778
+ H G++ AL +L++ R E+E E+E Q+ E +
Sbjct: 622 QAHSHRPSGKEEAL--------CQLQEENRRLSREQERLEAELAQEQESK---------- 663
Query: 779 LTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYL 838
Q+LE E ++E+ ++WEAQ+ +I+ WV+DEK +RGYL
Sbjct: 664 -------------------QRLEGE------RRETESNWEAQLADILSWVNDEKVSRGYL 698
Query: 839 QALASKMTEELEALRN---SSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQA 895
QALA+KM EELE+LRN +L R D WK RR K++ SARLELQSAL+AEIRAKQ
Sbjct: 699 QALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQG 758
Query: 896 IQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQH--SF 953
+QE L +V+ + + E +L+++EK++ L E+ L EELR+ ++ + S F
Sbjct: 759 LQERLTQVQEAQLQAERRLQEAEKQSQALQQELAML---REELRARGPVDTKPSNSLIPF 815
Query: 954 LAFLNTPTDALDQFETVDSTPLSVHTPTLRKKG-----------------CPGSTGFPPK 996
L+F ++ D+ P LR +G + G P K
Sbjct: 816 LSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAK 875
Query: 997 RKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQT 1056
+H +SF +PTKC +CTSLM+GL RQG C+ CG+ CH TC +AP CPVPP+
Sbjct: 876 PGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAP-PCPVPPDLL 934
Query: 1057 KGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVV 1116
+ LG+ P+ G GTAYEG + +P+P+GV++GWQR A + D +L L+D + + S PS
Sbjct: 935 RTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGA 994
Query: 1117 ISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEK 1176
+ QV+D+RD +FS + VLASDVIHA +D+P IFRVT SQL+ C++L+LA++E E+
Sbjct: 995 LLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGER 1054
Query: 1177 NKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGL 1236
+W+ VL EL ++L + R R VY KEAYD+ LPL+ T AAI+D +R+ALG EEGL
Sbjct: 1055 ERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGL 1114
Query: 1237 FVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLS 1296
FV+H+ ++I +VG+ +++ Q+ L P+ L+ V+ GR VRLF ++ L+ E K+
Sbjct: 1115 FVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIP 1174
Query: 1297 ETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSK-TRHRKFKEIQVPYNVQWMAIF 1355
E++GCQ + +G + LCVA+KRQVLCY+L R+ +E+Q P VQ + +
Sbjct: 1175 ESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLL 1234
Query: 1356 SEQLCVGFQSGFLRYPLNGEGNPYSM-LHSNDHTLSFIAHQPMDAICAVEISSKEYLLCF 1414
++LCVG GF YPL E P ++ L +A+ AVE+S E+LL F
Sbjct: 1235 GDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLF 1294
Query: 1415 NSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLK 1474
+ GIY D GR+SR EL+WPA P Y APYL+V+SEN++D+FDV EW+QT+PLK
Sbjct: 1295 TTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLK 1354
Query: 1475 KVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFR 1534
KVRPLN EGSL L G E +RL Y +N++AE DE +P+ +DNSR+Q+ R +KRR+ FR
Sbjct: 1355 KVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRT-KSKRRFFFR 1413
Query: 1535 VPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTV 1594
V EE++ QQRREML+DP +R+KLIS PTNFNH+ H+GP +G +D +P P+E V
Sbjct: 1414 VSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARD--KSPAPEEKGRV 1471
Query: 1595 FSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSE 1654
GS P R S S L R A GS G + KR+P S S
Sbjct: 1472 ARGS-----------GPQRPHSFSEAL--RRPASMGS---EGLGGDADPMKRKPWTSLSS 1515
Query: 1655 GSLSSGGMDQGSDAPA 1670
S+S QGS +PA
Sbjct: 1516 ESVS---CPQGSLSPA 1528
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 521 bits (1342), Expect = e-147
Identities = 279/551 (50%), Positives = 374/551 (67%), Gaps = 34/551 (6%)
Query: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
MS EVRLR+L+Q +LD +E LLD+L+ ++ E S L ++K + ++L+WA
Sbjct: 1 MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54
Query: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
+P ++K++RL R+DFEILKVIGRGAF EVAVVK+K +V+AMKI+NKW+MLKR E +
Sbjct: 55 EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114
Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174
Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
YLAE+V+AIDSVH+L YVHRDIKPDNIL+D GHIRLADFGSCLKL DGTV+S VAVGT
Sbjct: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234
Query: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
PDY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI+++K
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
Query: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358
E P V E A+D I+RL+C E RLG+ G DF+ HPFF G+DWD +R+ P+
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
Query: 359 IPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRV 418
P+ TDT NFD+ +D L ET+ A G HLPFVG++Y S L D
Sbjct: 355 TPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY-SCMALRDSE---- 409
Query: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQTVQAL 472
GPT ++L+ ++ L+ ++ + E + + E E++ E+ T++ L
Sbjct: 410 VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEVTLREL 466
Query: 473 QYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKA 532
Q + + LT ++L E+E +R T++ + QL EA A ++L+ RQ+
Sbjct: 467 QEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHVRQL-- 515
Query: 533 YEKQIKTLQQE 543
+++++ LQ E
Sbjct: 516 -QERMELLQAE 525
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 521 bits (1342), Expect = e-147
Identities = 279/551 (50%), Positives = 374/551 (67%), Gaps = 34/551 (6%)
Query: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
MS EVRLR+L+Q +LD +E LLD+L+ ++ E S L ++K + ++L+WA
Sbjct: 1 MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54
Query: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
+P ++K++RL R+DFEILKVIGRGAF EVAVVK+K +V+AMKI+NKW+MLKR E +
Sbjct: 55 EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114
Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174
Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
YLAE+V+AIDSVH+L YVHRDIKPDNIL+D GHIRLADFGSCLKL DGTV+S VAVGT
Sbjct: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234
Query: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
PDY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI+++K
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
Query: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358
E P V E A+D I+RL+C E RLG+ G DF+ HPFF G+DWD +R+ P+
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
Query: 359 IPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRV 418
P+ TDT NFD+ +D L ET+ A G HLPFVG++Y S L D
Sbjct: 355 TPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY-SCMALRDSE---- 409
Query: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQTVQAL 472
GPT ++L+ ++ L+ ++ + E + + E E++ E+ T++ L
Sbjct: 410 VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEVTLREL 466
Query: 473 QYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKA 532
Q + + LT ++L E+E +R T++ + QL EA A ++L+ RQ+
Sbjct: 467 QEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHVRQL-- 515
Query: 533 YEKQIKTLQQE 543
+++++ LQ E
Sbjct: 516 -QERMELLQAE 525
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 516 bits (1329), Expect = e-146
Identities = 279/556 (50%), Positives = 374/556 (67%), Gaps = 39/556 (7%)
Query: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
MS EVRLR+L+Q +LD +E LLD+L+ ++ E S L ++K + ++L+WA
Sbjct: 1 MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54
Query: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
+P ++K++RL R+DFEILKVIGRGAF EVAVVK+K +V+AMKI+NKW+MLKR E +
Sbjct: 55 EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114
Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174
Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
YLAE+V+AIDSVH+L YVHRDIKPDNIL+D GHIRLADFGSCLKL DGTV+S VAVGT
Sbjct: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234
Query: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
PDY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI+++K
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
Query: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358
E P V E A+D I+RL+C E RLG+ G DF+ HPFF G+DWD +R+ P+
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
Query: 359 IPEVSSPTDTSNFDVDDDCLK-----NSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDR 413
P+ TDT NFD+ +D L ET+ A G HLPFVG++Y S L D
Sbjct: 355 TPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSY-SCMALRDS 413
Query: 414 SCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQ 467
GPT ++L+ ++ L+ ++ + E + + E E++ E+
Sbjct: 414 E----VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEV 466
Query: 468 TVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAF 527
T++ LQ + + LT ++L E+E +R T++ + QL EA A ++L+
Sbjct: 467 TLRELQEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHV 517
Query: 528 RQIKAYEKQIKTLQQE 543
RQ+ +++++ LQ E
Sbjct: 518 RQL---QERMELLQAE 530
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 478 bits (1230), Expect = e-134
Identities = 257/497 (51%), Positives = 338/497 (68%), Gaps = 33/497 (6%)
Query: 60 AKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAET 119
A+P ++K++RL R+DFEILKVIGRGAF EVAVVK+K +V+AMKI+NKW+MLKR E
Sbjct: 64 AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
Query: 120 ACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAR 179
+CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MAR
Sbjct: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
Query: 180 FYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVG 239
FYLAE+V+AIDSVH+L YVHRDIKPDNIL+D GHIRLADFGSCLKL DGTV+S VAVG
Sbjct: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
Query: 240 TPDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 297
TPDY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI+++
Sbjct: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
Query: 298 KERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAP 357
KE P V E A+D I+RL+C E RLG+ G DF+ HPFF G+DWD +R+ P
Sbjct: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
Query: 358 YIPEVSSPTDTSNFDVDDDCLK-----NSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSD 412
+ P+ TDT NFD+ +D L ET+ A G HLPFVG++Y S L D
Sbjct: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSY-SCMALRD 422
Query: 413 RSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQEST 466
GPT ++L+ ++ L+ ++ + E + + E E++ E+
Sbjct: 423 SE----VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAE 475
Query: 467 QTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDA 526
T++ LQ + + LT ++L E+E +R T++ + QL EA A ++L+
Sbjct: 476 VTLRELQEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAH 526
Query: 527 FRQIKAYEKQIKTLQQE 543
RQ+ +++++ LQ E
Sbjct: 527 VRQL---QERMELLQAE 540
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 476 bits (1224), Expect = e-133
Identities = 367/1255 (29%), Positives = 612/1255 (48%), Gaps = 146/1255 (11%)
Query: 2 SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAK 61
S E R +++ + D ++ N C LLD L L + + LR+ KNI +L K
Sbjct: 6 SFETRFEKMDNLLRDPKSEVNSDC-----LLDGLDALVYDLDFPALRKNKNIDNFLSRYK 60
Query: 62 PFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC 121
+K++ +R+ ED+E++KVIGRGAFGEV +V+ K+ KV+AMK+L+K+EM+KR+++A
Sbjct: 61 DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF 120
Query: 122 FREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFY 181
F EERD++ ++ W+ L YAFQDD LY+VM+Y GGDL+ L+S ++ +PE ARFY
Sbjct: 121 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFY 178
Query: 182 LAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 241
AE+V+A+D++H + ++HRD+KPDN+L+D +GH++LADFG+C+K+ ++G V+ AVGTP
Sbjct: 179 TAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTP 238
Query: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
DYISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIMNHK
Sbjct: 239 DYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSL 297
Query: 302 QFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID--WDNIRNCEAPYI 359
FP D+S+ AK+LI + RE RLG+NG+E+ K+H FF W+ +R+ AP +
Sbjct: 298 TFPDD-NDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVV 356
Query: 360 PEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVT 419
P++SS DTSNFD ++ ET P P AF G+ LPFVGFTY S+ S
Sbjct: 357 PDLSSDIDTSNFDDLEEDKGEEETFPIP--KAFVGNQLPFVGFTYYSN--RRYLSSANPN 412
Query: 420 AGPTSLDLDVNVQRTLD-----------------------------------NNLATEAY 444
TS + D ++Q +L L E
Sbjct: 413 DNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGN 472
Query: 445 ERR-----IKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKL 499
+RR + ++E+EK+ L ++ E + + + + + E+ LK+++E L
Sbjct: 473 QRRNLESTVSQIEKEKMLLQHRINEYQRKAEQ------ENEKRRNVENEVSTLKDQLEDL 526
Query: 500 RKQVTES-------SHLEQQLEEAN-AVRQELDDAFRQIKAYEKQIKTLQQEREDLNKEL 551
+K S S L++QLEEAN +R E D A R K++ + K++ Q E LN+EL
Sbjct: 527 KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQ-LESLNREL 585
Query: 552 VQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVM 611
+ + L+N + + Q + ++ +E+ Q ++++ + + +
Sbjct: 586 QERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNL 645
Query: 612 QKVESLRQE----LRRTERAKKELEV-------------------HTEALAAEASKDRKL 648
+KVE R+E L +E+ K LE+ H A K + +
Sbjct: 646 EKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSI 705
Query: 649 REQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKRE 708
E ++E +L+ ++ + V IE Q + L DL++ E +E
Sbjct: 706 EEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQ--CSMLDVDLKQSQQKLEHLTGNKE 763
Query: 709 GIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFES--EFKQQYE 766
+ +E+KNL +L ++L L E+ + + + + ++E + E K+ E
Sbjct: 764 RME-DEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLE 822
Query: 767 REKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQ 826
E LT++ + ++ +L E + + +VK+L KE + + + IQ
Sbjct: 823 FELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKEL---KEEIEEKNRENLKKIQ 879
Query: 827 WVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSAL 886
+ +EK+ LA E E L L + ++ + ++ A + + +
Sbjct: 880 ELQNEKETLATQLDLAETKAES-EQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTV 938
Query: 887 DAEIRAKQAIQEELNKVKASN-IITECKLKDSEKKNLELLSEIEQLIKDTEE-LRSEKGI 944
A + +++ ++ N +TE K E+ LE EI L E+ + +E+ +
Sbjct: 939 SRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTL 998
Query: 945 EHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPTLRKKGCPGS----TGFPPKRKTH 1000
+ Q + + +N +D+ +T LRKK + K +
Sbjct: 999 KTQ-AVNKLAEIMNRKDFKIDR--------KKANTQDLRKKEKENRKLQLELNQEREKFN 1049
Query: 1001 QFFVK--------SFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVP 1052
Q VK +C L + L + E + ++ + + P
Sbjct: 1050 QMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIE--QLRAKLLDLSDSTSVASFP 1107
Query: 1053 -PEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKK-GWQRALAIVCDFKLFLY-DIAEGK 1109
++T G L P+ I EG + +P +K+ GW++ +V K+ Y D + +
Sbjct: 1108 SADETDGNL---PESRI----EGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKE 1160
Query: 1110 ASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKC 1164
S PS+V+ D+ F V V DV A ++IP IF++ L A+ +C
Sbjct: 1161 QSNPSMVLD-----IDKLFHVRPVTQGDVYRAETEEIPKIFQI----LYANEGEC 1206
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 464 bits (1193), Expect = e-130
Identities = 357/1104 (32%), Positives = 561/1104 (50%), Gaps = 180/1104 (16%)
Query: 2 SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAK 61
+G R R+LE I D + N VE+LLD L L + + LR+ KNI +L +
Sbjct: 22 AGASRQRKLEALIRDPRSPIN-----VESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYE 76
Query: 62 PFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC 121
K++ +++ ED++++KVIGRGAFGEV +V+ K + KV+AMK+L+K+EM+KR+++A
Sbjct: 77 KIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAF 136
Query: 122 FREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFY 181
F EERD++ ++ W+ L YAFQDD LY+VM+Y GGDL+ L+S ++ +PE A+FY
Sbjct: 137 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFY 194
Query: 182 LAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 241
AE+V+A+D++H + +HRD+KPDN+L+D +GH++LADFG+C+K+ E G V AVGTP
Sbjct: 195 TAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTP 254
Query: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
DYISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIM+HK
Sbjct: 255 DYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSL 313
Query: 302 QFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID--WDNIRNCEAPYI 359
FP + ++S++AK+LI + RE RLG+NG+E+ ++HPFF WDNIR AP +
Sbjct: 314 CFP-EDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVV 372
Query: 360 PEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFT-YTSSCVLSDRSCLRV 418
PE+SS D+SNFD +D + ET P P AF G+ LPF+GFT Y + +LSD R
Sbjct: 373 PELSSDIDSSNFDDIEDDKGDVETFPIP--KAFVGNQLPFIGFTYYRENLLLSDSPSCRE 430
Query: 419 TAGPTSL--DLDVNVQR---TLDNNL-----ATEAYERRIK----RLEQEKLELSRKLQE 464
T S + +Q+ TL+ +L A E E++ K RLE+ EL ++
Sbjct: 431 TDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITL 490
Query: 465 STQTVQALQYSTVDGPLTASKDLE------------------IKNLKEEIEKLRKQVTES 506
AL+ + L K+ E + +LK+++E L+K+ S
Sbjct: 491 RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS 550
Query: 507 -------SHLEQQLEEANA-VRQELDDAFRQIKAY---EKQIKTLQQERED--------- 546
+ L++QL+E NA +R E D A R K KQI+ L+ D
Sbjct: 551 QISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLE 610
Query: 547 -----LNKELVQASERLKNQ---------------------SKELKDAHCQRKLAMQEFM 580
L KE + L+++ ++LK+ E
Sbjct: 611 TAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKR 670
Query: 581 EINERLTELHTQK-------------------QKLARHVRDKEEEVD--LVMQKVESLRQ 619
++ ER T+L +K Q+ A H K D + + +E +
Sbjct: 671 QLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKS 730
Query: 620 ELRRTERAKKELEVHT-----EALAAEASKDRKLREQSEHYSKQLENELEGLKQKQI-SY 673
E + E KK LE T E L EA K L + S+Q NEL LKQK + +
Sbjct: 731 EAMK-EMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINEL--LKQKDVLNE 787
Query: 674 SPGVCSIEHQQEITK---LKTDLEKK-----SIFYEEELSKREGIHANEIK--------N 717
+++ +QE K + DL+ + ++ E+ K+E H E+K
Sbjct: 788 DVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAE 847
Query: 718 LKKELHDSEGQQLALNKEIMILK--DKLEKTRRESQSEREEFESEFKQQYEREKVLLTEE 775
L+KE D++GQ L ++ + L KT+ E E +++ ++ +++K L +E
Sbjct: 848 LRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDE 907
Query: 776 NKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK--------KESVAHWEAQITEIIQW 827
L ++L+ T ++ + EE+ DL + KE +A + ++TE
Sbjct: 908 RDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDAT 967
Query: 828 VSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALD 887
++ ++ L + + + E E L N + D+ ++ R ++SA +A+
Sbjct: 968 IASLEETNRTLTSDVANLANEKEELNN-----KLKDVQEQLSRLKDEEISA-----AAIK 1017
Query: 888 AEIRAKQAIQEELNKVKASNIITEC-----------------KLKDSEKKNLELLSEIE- 929
A+ KQ + E K +A N + E K K++ K ++EL SE E
Sbjct: 1018 AQFE-KQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREK 1076
Query: 930 ---QLIKDTEELRSEKGIEHQDSQ 950
Q+IK +EL + ++SQ
Sbjct: 1077 LTQQMIKYQKELNEMQAQIAEESQ 1100
Score = 88.6 bits (218), Expect = 5e-17
Identities = 117/560 (20%), Positives = 245/560 (43%), Gaps = 67/560 (11%)
Query: 410 LSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTV 469
L D++CL TA +N+Q L++ ERR ++ S + + +
Sbjct: 602 LQDKNCLLETAKLKLEKEFINLQSALES-------ERR------DRTHGSEIINDLQGRI 648
Query: 470 QALQYSTVDGPLTASK-DLEIKNLKEEIEKLRKQVTESSHLEQQLE-EANAVRQELDDAF 527
L+ +G + +K +LE + L+E L K E S++E + + ++Q L+
Sbjct: 649 CGLEEDLKNGKILLAKVELEKRQLQERFTDLEK---EKSNMEIDMTYQLKVIQQSLE--- 702
Query: 528 RQIKAYEKQIKTLQQEREDLNKELVQA-SERLKNQSKELKDAHCQRKLAMQEFMEINERL 586
Q +A K K ++ + + + +A SE +K K+L + ++ +E +R
Sbjct: 703 -QEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRC 761
Query: 587 TELHTQKQKLARHVRDKEEEVDLVMQKVESL----RQELRRTERAKKELEVHTEALAAEA 642
+ L ++ + + + ++ D++ + V +L QE ++ + +L++ T+ +
Sbjct: 762 SLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLK 821
Query: 643 SKDRKLREQSEHYSKQ---LENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIF 699
+++L++++ H + LE + L++++ + ++ Q E + + L K +
Sbjct: 822 MSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVR 881
Query: 700 YEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRE------SQSE 753
+E + + E++ K+EL D E LA EI + K E+ R S E
Sbjct: 882 ELKEECEEKTKLGKELQQKKQELQD-ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940
Query: 754 REEF--ESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKK 811
+E+ E E K+ R K LTE++ + S L N+ L +V +LA++K
Sbjct: 941 KEKIMKELEIKEMMARHKQELTEKDATIAS-----------LEETNRTLTSDVANLANEK 989
Query: 812 ESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWK---- 867
E + + + E + + DE+ + ++A K L+ ++ A M K
Sbjct: 990 EELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVK 1049
Query: 868 ------MRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKN 921
+RR K + +EL+S + + Q+ELN+++A ++ + +
Sbjct: 1050 RGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQA-------QIAEESQIR 1102
Query: 922 LELLSEIEQLIKDTEELRSE 941
+EL ++ D E+LRS+
Sbjct: 1103 IELQMTLDSKDSDIEQLRSQ 1122
Score = 40.0 bits (92), Expect = 0.020
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1073 EGHVRIPKPAGVKK-GWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVS 1131
EG + +P KK GW + IV K+ YD + K ++ + D+ F V
Sbjct: 1154 EGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDI----DKLFHVR 1209
Query: 1132 SVLASDVIHASRKDIPCIFRV 1152
V +DV A K+IP IF++
Sbjct: 1210 PVTQTDVYRADAKEIPRIFQI 1230
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 404 bits (1037), Expect = e-112
Identities = 315/1052 (29%), Positives = 533/1052 (50%), Gaps = 150/1052 (14%)
Query: 27 SVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRG 86
S E +LD L L++EC+ L + K++ ++ +++++++ +DFE+ ++G G
Sbjct: 47 SREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCG 106
Query: 87 AFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQD 146
F EV VV+ K ++AMK++ K +L + + + F EER++L + WI L YAFQD
Sbjct: 107 HFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQD 166
Query: 147 DNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDN 206
N+LYLVM+Y GGDLL+LL+++ED+L E++ +FYLAE+++A+ SVH + YVHRDIKP+N
Sbjct: 167 KNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPEN 226
Query: 207 ILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME-DGKGRYGPECDW 265
IL+D GHI+L DFGS K+ + V + + +GTPDY++PE+L M DGKG YG +CDW
Sbjct: 227 ILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDW 286
Query: 266 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSR 325
WS+GV YEM+YG +PF + T+ IMN + +FP VS + DLI+ L+C +
Sbjct: 287 WSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDD-PKVSSDFLDLIQSLLCGQ 345
Query: 326 EHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMP 385
+ RL G+ HPFFS IDW+NIRN P++P + S DTSNFD + KNS
Sbjct: 346 KERLKFEGL---CCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPE---KNSWVSS 399
Query: 386 PP---THTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATE 442
P + + FSG LPFVGF+Y+ + + RS V+ + ++ L + +
Sbjct: 400 SPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQ 459
Query: 443 AYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQ 502
+ + ++EQE L R++ E V+A + + K++E+K + + L +
Sbjct: 460 DSQDKCHKMEQEMTRLHRRVSE----VEA---------VLSQKEVELKASETQRSLLEQD 506
Query: 503 ----VTESSHLEQQLEEAN-AVRQELDDAFRQIKAYEKQIKTLQQERE------------ 545
+TE S L++ LE+A V QE D A + + +Q + LQ+ +E
Sbjct: 507 LATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 566
Query: 546 ---DLNKELVQASERLKNQSKELKDA------------HCQRKLAM---QEFMEINE--R 585
L ++LV A R EL+++ CQ KL Q E+ E +
Sbjct: 567 MMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAK 626
Query: 586 LTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRT-ERAKKELEVHTEALAAEASK 644
L +++ ++Q + +++K E+ + L Q +R+ ERA++ELE +
Sbjct: 627 LEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGI 686
Query: 645 DRKLREQSEHYSKQLENELEG------LKQKQISYSPGVCSIEHQ-QEITKLKTDLEKKS 697
+KL E E K E ++ LKQK+ Y + +++Q ++ K LE
Sbjct: 687 RKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMM 746
Query: 698 IFYEEELSKREGIHA----------NEIKNLKKELHD-SEGQQLALNKEIMILKDKLEKT 746
+EEE ++ I + ++I++L++ + + SE +LA N + T
Sbjct: 747 QRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLF--------T 798
Query: 747 RRESQSEREEFESEFKQQ---YEREKVLLTEENKKLTSELDKL---------------TT 788
+R +++ EE SE +QQ E + L +N+KL +L+K+ T
Sbjct: 799 QRNMKAQ-EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETR 857
Query: 789 LYENLSIHNQQLEEEVKDLADKKESVAHWEAQI------------------TEIIQWVSD 830
L E H +Q E + L + + S+ E+Q+ TE+ + ++
Sbjct: 858 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAE 917
Query: 831 EKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRF----AKLD-----MSARLE 881
++ L A ++ + +ALRNS T TD+ ++ + A+L+ +S +L+
Sbjct: 918 AEEEIQALTAHRDEIQRKFDALRNSC--TVITDLEEQLNQLTEDNAELNNQNFYLSKQLD 975
Query: 882 LQSALDAEIRAKQAIQEELNKVKASNIITECKLK-DSEKKNLELL----SEIEQLIKDTE 936
S + EI ++ + L + ITE +++ S+K+ +E L + +E+ + D E
Sbjct: 976 EASGANDEIVQLRSEVDHLRRE-----ITEREMQLTSQKQTMEALKTTCTMLEEQVMDLE 1030
Query: 937 ELRSEKGIEHQDSQHSFLAFLNTPTDALDQFE 968
L E + + + A+ + D QFE
Sbjct: 1031 ALNDEL----LEKERQWEAWRSVLGDEKSQFE 1058
Score = 178 bits (452), Expect = 4e-44
Identities = 239/1114 (21%), Positives = 448/1114 (40%), Gaps = 153/1114 (13%)
Query: 442 EAYERRIKRLEQEKLEL----------SRKLQESTQTVQALQYSTVDGPLTASKDLEIKN 491
+A E I L Q+K L +RKL+E + + +S + L L +
Sbjct: 803 KAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVS 862
Query: 492 LKEEIEKL--RKQVTESS----HLEQQLEEANAVRQELDDAFRQIKAY--------EKQI 537
L+ E +KL ++Q+TE E QL A R L+ RQ K E++I
Sbjct: 863 LEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEI 922
Query: 538 KTLQQEREDLNK-------------ELVQASERLKNQSKELKDAHCQRKLAMQEFMEINE 584
+ L R+++ + +L + +L + EL + + + E N+
Sbjct: 923 QALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 982
Query: 585 RLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASK 644
+ +L ++ L R + ++E ++ Q +E+L+ E +LE + L + +
Sbjct: 983 EIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQ 1042
Query: 645 DRKLRE-------QSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKS 697
R Q E ++L+ L+ KQ + I +++ +L K
Sbjct: 1043 WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ---RITESRQVVELAVKEHKAE 1099
Query: 698 IFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEF 757
I ++ K + + A ++L +L+D E + L L+ KLE T RE + E
Sbjct: 1100 ILALQQALKEQKLKA---ESLSDKLNDLEKKHAMLEMNARSLQQKLE-TERELKQRLLEE 1155
Query: 758 ESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHW 817
+++ +QQ + +K + + L LD+ L S QLE + +K +
Sbjct: 1156 QAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGT 1215
Query: 818 EAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMS 877
+Q T++I ++ + D + +E AL T +P + ++
Sbjct: 1216 ISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPAL--------PTQVPLQYN-----ELK 1262
Query: 878 ARLELQSALDAEIR-AKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTE 936
LE + A AE+ A Q + EL + K ++ + + Q I +
Sbjct: 1263 LALEKEKARCAELEEALQKTRIELRSAREE----AAHRKATDHPHPSTPATARQQIAMSA 1318
Query: 937 ELRSEKGIEHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPK 996
+RS EHQ S S LA P+ R+K F +
Sbjct: 1319 IVRSP---EHQPSAMSLLA-----------------------PPSSRRKESSTPEEFSRR 1352
Query: 997 RKT-------HQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTC 1049
K H+F V TKC C V RQ C C CH C P TC
Sbjct: 1353 LKERMHHNIPHRFNVGLNMRATKCAVCLDT-VHFGRQASKCLECQVMCHPKCSTCLPATC 1411
Query: 1050 PVPPEQTK-----------GPLGIDPQKGIGTAY-EGHVRIPKP-AGVKKGWQRALAIVC 1096
+P E G+ ++ + + EG +++P+ ++GW R ++
Sbjct: 1412 GLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLE 1471
Query: 1097 DFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSV-SSVLASDVIHASRKDIPCIFRVTAS 1155
K+ +YD +A Q V ++ + D + S+ +V AS++ + ++ D+P I ++ +
Sbjct: 1472 GSKVLIYDNEAREAGQRPVEEFELC-LPDGDVSIHGAVGASELANTAKADVPYILKMESH 1530
Query: 1156 QLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIK 1215
+ ++ +LA + +K +WV L + + R+++ K +S L L
Sbjct: 1531 PHTTCWPGRTLYLLAPSFPDKQRWVTALESV--VAGGRVSREKAEADAKLLGNSLLKLEG 1588
Query: 1216 TTQ----AAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVIS 1271
+ + + +G EEGL+ ++V K+ + V + QI +I + + + +I+
Sbjct: 1589 DDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIA 1648
Query: 1272 GRNRHVRLFPMSALDGRETDFYKLSE----------TKGCQTVTSGKVRHGALTCLCVAM 1321
G R + L + + + ++ KGC +GK+ +G C+C AM
Sbjct: 1649 GEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGL--CICAAM 1706
Query: 1322 KRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVG----FQSGFLRYPLNGEGN 1377
+V+ ++ +++ KEI+ + + + +G ++ +Y L
Sbjct: 1707 PSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLE---- 1762
Query: 1378 PYSMLHSNDHTLS---FIAHQPMDAICAVEISS----KEYLLCFNSIGIYTDCQGRRSRQ 1430
L NDH+L+ F A + V+++S +EYLLCF+ G++ D GRRSR
Sbjct: 1763 --EFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRT 1820
Query: 1431 QELMWPANPSSCCYNAPYLSVYSENAVDIFDVNS 1464
+L W P + Y PYL V N++++ ++ +
Sbjct: 1821 DDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQA 1854
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 308 bits (790), Expect = 2e-83
Identities = 169/375 (45%), Positives = 225/375 (60%), Gaps = 43/375 (11%)
Query: 66 KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125
++K+ RL EDFE LKVIGRGAFGEV +V+ K+ V+AMKIL K +ML++ + R E
Sbjct: 78 RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
Query: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
RD+LV D+ W+ + Y+FQD NLYL+M++ GGD++TLL K +D L E+ +FY+AE
Sbjct: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196
Query: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL----------------KLMED 229
V+AIDS+HQL ++HRDIKPDN+L+D GH++L+DFG C L D
Sbjct: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256
Query: 230 GTVQSS------------------VAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC 271
T Q+ VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311
Query: 272 MYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQ 331
MYEML G PF +E+ ETY K+MN KE FP +V +SE AKDLI R C EHR+G
Sbjct: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV-PISEKAKDLILRFCCEWEHRIGA 370
Query: 332 NGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD--VDDDCLKNSETMPPPTH 389
G+E+ K + FF G+DW++IR A E+ S DTSNFD + D LK +
Sbjct: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
Query: 390 TAFSGHHLPFVGFTY 404
T + F+ +TY
Sbjct: 431 TDYKNKDWVFINYTY 445
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 212 bits (540), Expect = 2e-54
Identities = 133/367 (36%), Positives = 206/367 (56%), Gaps = 24/367 (6%)
Query: 62 PFTSKVKQ--MRLHREDFEILKVIGRGAFGEVAVVKLK---NADKVFAMKILNKWEMLKR 116
P T VK+ + FE+LKV+G+G+FG+V +V+ K +A +++AMK+L K LK
Sbjct: 56 PITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKK-ASLKV 114
Query: 117 AETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176
+ + ERD+LV ++ +I LHYAFQ + LYL++D+ GGD+ T LSK E E+
Sbjct: 115 RDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEE 173
Query: 177 MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSV 236
+FYLAE+ +A+D +HQL V+RD+KP+NIL+D GHI+L DFG K D ++
Sbjct: 174 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG-LSKESVDQEKKAYS 232
Query: 237 AVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 296
GT +Y++PE++ + + DWWS GV M+EML G PF + ET I+
Sbjct: 233 FCGTVEYMAPEVV-----NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL- 286
Query: 297 HKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLGQNGIEDFKKHPFFSGIDWDNI--RN 353
K + P +S A+ L+R L + +RLG G+E+ K+H FF+ IDWD + R
Sbjct: 287 -KAKLGMP---QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKRE 342
Query: 354 CEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDR 413
+ P+ P P DT FD + ++ P A + H F GF++ ++ + +
Sbjct: 343 VQPPFKPASGKPDDTFCFDPEFTAKTPKDS---PGLPASANAHQLFKGFSFVATSIAEEY 399
Query: 414 SCLRVTA 420
+T+
Sbjct: 400 KITPITS 406
Score = 89.0 bits (219), Expect = 4e-17
Identities = 90/285 (31%), Positives = 139/285 (48%), Gaps = 33/285 (11%)
Query: 75 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN-GD 133
E +E+ + IG G++ + FA+KI++K KR + EE ++L+ G
Sbjct: 424 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK---SKRDPS----EEIEILMRYGQ 476
Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVIAID 190
+ I TL F D +YLV D GG+LL + K F +R D+ L + +D
Sbjct: 477 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDI----LYVISKTVD 532
Query: 191 SVHQLHYVHRDIKPDNIL-MDMNGH---IRLADFGSCLKLM-EDGTVQSSVAVGTPDYIS 245
+H VHRD+KP NIL MD + IR+ DFG +L E+G + + T ++++
Sbjct: 533 YLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCY--TANFVA 590
Query: 246 PEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFP- 304
PE+L M+ G Y CD WSLGV Y ML G TPF A +T +I+ +F
Sbjct: 591 PEVL--MQQG---YDAACDIWSLGVLFYTMLAGYTPF-ANGPNDTPEEILLRIGNGKFSL 644
Query: 305 --AQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID 347
++S+ AKDL+ ++ H+ + E KH + + D
Sbjct: 645 SGGNWDNISDGAKDLLSHMLHMDPHQ--RYTAEQILKHSWITHRD 687
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 209 bits (531), Expect = 2e-53
Identities = 125/344 (36%), Positives = 204/344 (59%), Gaps = 20/344 (5%)
Query: 77 FEILKVIGRGAFGEVAVV-KLKNAD--KVFAMKILNKWEMLKRAETACFREERDVLVNGD 133
FE+LKV+G+G++G+V +V K+K +D +++AMK+L K LK + + ERD+L +
Sbjct: 67 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK-ATLKVRDRVRSKMERDILAEVN 125
Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193
+ +I LHYAFQ + LYL++D+ GGDL T LSK E E+ +FYLAE+ +A+D +H
Sbjct: 126 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 184
Query: 194 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 253
L ++RD+KP+NIL+D GHI++ DFG + + D ++ GT +Y++PE++
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMAPEVV---- 239
Query: 254 DGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSEN 313
+ + DWWS GV M+EML G PF + ET I+ K + P ++ +++
Sbjct: 240 -NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQFLSGEAQS 296
Query: 314 -AKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSN 370
+ L +R C+R G +G+E+ K+HPFF IDW+ + + + P+ P V P DT +
Sbjct: 297 LLRALFKRNPCNR-LGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 355
Query: 371 FDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRS 414
F D + + T P + + HHL F GF++ +S ++ + S
Sbjct: 356 F--DPEFTARTPTDSPGVPPSANAHHL-FRGFSFVASSLIQEPS 396
Score = 88.6 bits (218), Expect = 5e-17
Identities = 82/279 (29%), Positives = 134/279 (48%), Gaps = 30/279 (10%)
Query: 62 PFTSKVKQMRLHRED-FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
P ++ +H D +EI + IG G++ K D +A+KI++K KR +
Sbjct: 407 PIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK---SKRDPS- 462
Query: 121 CFREERDVLVN-GDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSK---FEDRLPED 176
EE ++L+ G + I TL + D +YLVM+ GG+LL + + F +R D
Sbjct: 463 ---EEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASD 519
Query: 177 MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILM-DMNGH---IRLADFGSCLKLMEDGTV 232
+ L + +D +H VHRD+KP NIL D +G IR+ DFG K + G
Sbjct: 520 V----LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA-KQLRAGNG 574
Query: 233 QSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFY---AESLVE 289
T ++++PE+L+ + Y CD WSLG+ +Y ML G TPF ++ E
Sbjct: 575 LLMTPCYTANFVAPEVLK-----RQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEE 629
Query: 290 TYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHR 328
+I + K +S+ AKD++ +++ H+
Sbjct: 630 ILARIGSGKYALS-GGNWDSISDAAKDVVSKMLHVDPHQ 667
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 209 bits (531), Expect = 2e-53
Identities = 125/344 (36%), Positives = 204/344 (59%), Gaps = 20/344 (5%)
Query: 77 FEILKVIGRGAFGEVAVV-KLKNAD--KVFAMKILNKWEMLKRAETACFREERDVLVNGD 133
FE+LKV+G+G++G+V +V K+K +D +++AMK+L K LK + + ERD+L +
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK-ATLKVRDRVRSKMERDILAEVN 117
Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193
+ +I LHYAFQ + LYL++D+ GGDL T LSK E E+ +FYLAE+ +A+D +H
Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 176
Query: 194 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 253
L ++RD+KP+NIL+D GHI++ DFG + + D ++ GT +Y++PE++
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMAPEVV---- 231
Query: 254 DGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSEN 313
+ + DWWS GV M+EML G PF + ET I+ K + P ++ +++
Sbjct: 232 -NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQFLSGEAQS 288
Query: 314 -AKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSN 370
+ L +R C+R G +G+E+ K+HPFF IDW+ + + + P+ P V P DT +
Sbjct: 289 LLRALFKRNPCNR-LGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 347
Query: 371 FDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRS 414
F D + + T P + + HHL F GF++ +S ++ + S
Sbjct: 348 F--DPEFTARTPTDSPGVPPSANAHHL-FRGFSFVASSLIQEPS 388
Score = 88.6 bits (218), Expect = 5e-17
Identities = 82/279 (29%), Positives = 134/279 (48%), Gaps = 30/279 (10%)
Query: 62 PFTSKVKQMRLHRED-FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
P ++ +H D +EI + IG G++ K D +A+KI++K KR +
Sbjct: 399 PIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK---SKRDPS- 454
Query: 121 CFREERDVLVN-GDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSK---FEDRLPED 176
EE ++L+ G + I TL + D +YLVM+ GG+LL + + F +R D
Sbjct: 455 ---EEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASD 511
Query: 177 MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILM-DMNGH---IRLADFGSCLKLMEDGTV 232
+ L + +D +H VHRD+KP NIL D +G IR+ DFG K + G
Sbjct: 512 V----LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA-KQLRAGNG 566
Query: 233 QSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFY---AESLVE 289
T ++++PE+L+ + Y CD WSLG+ +Y ML G TPF ++ E
Sbjct: 567 LLMTPCYTANFVAPEVLK-----RQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEE 621
Query: 290 TYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHR 328
+I + K +S+ AKD++ +++ H+
Sbjct: 622 ILARIGSGKYALS-GGNWDSISDAAKDVVSKMLHVDPHQ 659
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 206 bits (525), Expect = 1e-52
Identities = 121/332 (36%), Positives = 195/332 (58%), Gaps = 24/332 (7%)
Query: 50 EKNILEYLEWAKP-FTSKVK---QMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAM 105
++++ E+L AK F K + Q H + FE +K +G G+FG V +VK K +AM
Sbjct: 13 QESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAM 72
Query: 106 KILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTL 165
KIL+K +++K + E+ +L + ++ L ++F+D++NLY+VM+Y GG++ +
Sbjct: 73 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSH 132
Query: 166 LSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLK 225
L + R E ARFY A++V+ + +H L ++RD+KP+N+L+D G+I++ DFG +
Sbjct: 133 LRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191
Query: 226 LMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAE 285
+ ++ GTP+Y++PEI+ + KG Y DWW+LGV +YEM G PF+A+
Sbjct: 192 VKG----RTWTLCGTPEYLAPEIILS----KG-YNKAVDWWALGVLIYEMAAGYPPFFAD 242
Query: 286 SLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLG--QNGIEDFKKHPF 342
++ Y KI++ K RF + S + KDL+R L+ R G +NG+ D K H +
Sbjct: 243 QPIQIYEKIVSGKVRFP-----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297
Query: 343 FSGIDWDNI--RNCEAPYIPEVSSPTDTSNFD 372
F+ DW I R EAP+IP+ P DTSNFD
Sbjct: 298 FATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 329
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 206 bits (525), Expect = 1e-52
Identities = 125/336 (37%), Positives = 189/336 (56%), Gaps = 19/336 (5%)
Query: 76 DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
DF+ LKVIG+G +G+V + K K+ +A+K+L K +LK+ E + ER VL+ N +
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
++ L Y+FQ LY V+DY GG+L L + E R E ARFY AE+ AI +H
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR-ERRFLEPRARFYAAEVASAIGYLHS 152
Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
L+ ++RD+KP+NIL+D GH+ L DFG C + +E S+ GTP+Y++PE+L+
Sbjct: 153 LNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFC-GTPEYLAPEVLR---- 207
Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENA 314
K Y DWW LG +YEML+G PFY++ + + Y I++ + Q P T A
Sbjct: 208 -KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVA---A 261
Query: 315 KDLIRRLI-CSREHRLGQNG-IEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSN 370
DL++ L+ + RLG + K H FFS I+WD++ + P+ P V+ P D +
Sbjct: 262 CDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 321
Query: 371 FDVD--DDCLKNSETMPPPTHTAFSGHHLPFVGFTY 404
FD + + + S P T + SG F+GF+Y
Sbjct: 322 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 206 bits (525), Expect = 1e-52
Identities = 125/336 (37%), Positives = 189/336 (56%), Gaps = 19/336 (5%)
Query: 76 DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
DF+ LKVIG+G +G+V + K K+ +A+K+L K +LK+ E + ER VL+ N +
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
++ L Y+FQ LY V+DY GG+L L + E R E ARFY AE+ AI +H
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR-ERRFLEPRARFYAAEVASAIGYLHS 212
Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
L+ ++RD+KP+NIL+D GH+ L DFG C + +E S+ GTP+Y++PE+L+
Sbjct: 213 LNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFC-GTPEYLAPEVLR---- 267
Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENA 314
K Y DWW LG +YEML+G PFY++ + + Y I++ + Q P T A
Sbjct: 268 -KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVA---A 321
Query: 315 KDLIRRLI-CSREHRLGQNG-IEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSN 370
DL++ L+ + RLG + K H FFS I+WD++ + P+ P V+ P D +
Sbjct: 322 CDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 381
Query: 371 FDVD--DDCLKNSETMPPPTHTAFSGHHLPFVGFTY 404
FD + + + S P T + SG F+GF+Y
Sbjct: 382 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 206 bits (523), Expect = 2e-52
Identities = 116/312 (37%), Positives = 187/312 (59%), Gaps = 20/312 (6%)
Query: 71 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV 130
RL ++F +KV+G+G+FG+V + +LK D+V+A+K+L K +L+ + C E+ +L
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461
Query: 131 NG-DNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAI 189
+ ++T L+ FQ + L+ VM+Y GGDL+ + + + E +RFY AE+ A+
Sbjct: 462 LARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSR-KFDEPRSRFYAAEVTSAL 520
Query: 190 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 249
+HQ ++RD+K DNIL+D GH +LADFG C + + +G V ++ GTPDYI+PEIL
Sbjct: 521 MFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNG-VTTTTFCGTPDYIAPEIL 579
Query: 250 QAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTD 309
Q +E YGP DWW+LGV MYEM+ G+ PF A++ + + I++ + +P
Sbjct: 580 QELE-----YGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILH--DDVLYPVW--- 629
Query: 310 VSENAKDLIRRLICSREH-RLG----QNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEV 362
+S+ A +++ + H RLG QNG + K+HPFF IDW + + + P+ P +
Sbjct: 630 LSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRI 689
Query: 363 SSPTDTSNFDVD 374
+ D +NFD D
Sbjct: 690 KTKRDVNNFDQD 701
Score = 51.6 bits (122), Expect = 6e-06
Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 3/70 (4%)
Query: 1000 HQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPE---QT 1056
H+F + ++ PT C C SL+ GL+RQG C+VC + H C C V +
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKV 302
Query: 1057 KGPLGIDPQK 1066
LG+ P K
Sbjct: 303 LADLGVTPDK 312
Score = 34.7 bits (78), Expect = 0.82
Identities = 17/51 (33%), Positives = 22/51 (43%), Gaps = 1/51 (1%)
Query: 1000 HQFFVKSFTTPTKCHQCTSLMVGLI-RQGCSCEVCGFSCHITCVNKAPTTC 1049
H+F PT C C + G+I +QG C+VC H C T C
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKC 220
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 206 bits (523), Expect = 2e-52
Identities = 117/320 (36%), Positives = 186/320 (58%), Gaps = 25/320 (7%)
Query: 58 EWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRA 117
+W P Q H + FE +K +G G+FG V +VK K +AMKIL+K +++K
Sbjct: 22 KWESP-----AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLK 76
Query: 118 ETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDM 177
+ E+ +L + ++ L ++F+D++NLY+VM+Y GG++ + L + R E
Sbjct: 77 QIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPH 135
Query: 178 ARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVA 237
ARFY A++V+ + +H L ++RD+KP+N+L+D G+I++ DFG ++ ++
Sbjct: 136 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTL 191
Query: 238 VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 297
GTP+Y++PEI+ + KG Y DWW+LGV +YEM G PF+A+ ++ Y KI++
Sbjct: 192 CGTPEYLAPEIILS----KG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 246
Query: 298 KERFQFPAQVTDVSENAKDLIRRLI-CSREHRLG--QNGIEDFKKHPFFSGIDWDNI--R 352
K RF + S + KDL+R L+ R G +NG+ D K H +F+ DW I R
Sbjct: 247 KVRFP-----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQR 301
Query: 353 NCEAPYIPEVSSPTDTSNFD 372
EAP+IP+ P DTSNFD
Sbjct: 302 KVEAPFIPKFKGPGDTSNFD 321
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 206 bits (523), Expect = 2e-52
Identities = 127/389 (32%), Positives = 207/389 (53%), Gaps = 24/389 (6%)
Query: 76 DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNK 135
DFE +K+I GA+G V +V+ ++ + FA+K +NK ++ R + ERD+L +N
Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
Query: 136 WITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQL 195
++ ++ +F+ +L +VM+Y GGD TLL LP DMAR Y AE V+A++ +H
Sbjct: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-LPVDMARLYFAETVLALEYLHNY 484
Query: 196 HYVHRDIKPDNILMDMNGHIRLADFG-SCLKLME------DGTVQSSV-------AVGTP 241
VHRD+KPDN+L+ GHI+L DFG S + LM +G ++ GTP
Sbjct: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544
Query: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
+YI+PE++ + YG DWW++GV +YE L G PF+ ++ E +G++++ +
Sbjct: 545 EYIAPEVI-----FRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS--DEI 597
Query: 302 QFPAQVTDVSENAKDLIRRLI-CSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
+P + +A+DLI RL+ S RLG G + K+HPFF +DW + +A ++P
Sbjct: 598 MWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVP 657
Query: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLP-FVGFTYTSSCVLSDRSCLRVT 419
++ + DTS FD + ++ + T+ S +P F ++ S V S L V
Sbjct: 658 QLEAEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQ 717
Query: 420 AGPTSLDLDVNVQRTLDNNLATEAYERRI 448
PT + + R + Y RR+
Sbjct: 718 PTPTFAERSFSEDREEGWERSEVDYGRRL 746
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 205 bits (521), Expect = 4e-52
Identities = 122/332 (36%), Positives = 192/332 (57%), Gaps = 31/332 (9%)
Query: 57 LEWAKPFTSKVKQMRLHR-----------EDFEILKVIGRGAFGEVAVVKLKNADKVFAM 105
+E K F +K K+ L + EDFE K +G G+FG V +VK K ++ +AM
Sbjct: 13 VESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAM 72
Query: 106 KILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTL 165
KIL+K +++K + E+ +L + ++ L YAF+D++NLY+VM+Y GG++ +
Sbjct: 73 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSH 132
Query: 166 LSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLK 225
L + R E ARFY A++V+ + +H L ++RD+KP+N+L+D G+I++ DFG +
Sbjct: 133 LRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR 191
Query: 226 LMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAE 285
+ ++ GTP+Y++PEI+ + KG Y DWW+LGV +YEM G PF+A+
Sbjct: 192 VKG----RTWTLCGTPEYLAPEIILS----KG-YNKAVDWWALGVLIYEMAAGYPPFFAD 242
Query: 286 SLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLG--QNGIEDFKKHPF 342
++ Y KI++ K RF + S + KDL+R L+ R G +NG+ D K H +
Sbjct: 243 QPIQIYEKIVSGKVRFP-----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKW 297
Query: 343 FSGIDWDNI--RNCEAPYIPEVSSPTDTSNFD 372
F+ DW I R EAP+IP+ DTSNFD
Sbjct: 298 FATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD 329
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 204 bits (519), Expect = 6e-52
Identities = 120/303 (39%), Positives = 178/303 (58%), Gaps = 19/303 (6%)
Query: 76 DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
DF LKVIG+G+FG+V + + K + +A+K+L K +LK+ E ER+VL+ N +
Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
++ LH++FQ + LY V+DY GG+L L + E E ARFY AE+ A+ +H
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 215
Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
L+ V+RD+KP+NIL+D GHI L DFG C + +E + S+ GTP+Y++PE+L
Sbjct: 216 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC-GTPEYLAPEVLH---- 270
Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQV-TDVSEN 313
K Y DWW LG +YEMLYG PFY+ + E Y I+N P Q+ +++ +
Sbjct: 271 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK------PLQLKPNITNS 323
Query: 314 AKDLIRRLI-CSREHRLG-QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPEVSSPTDTS 369
A+ L+ L+ R RLG ++ + K H FFS I+WD++ N P+ P VS P D
Sbjct: 324 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 383
Query: 370 NFD 372
+FD
Sbjct: 384 HFD 386
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 204 bits (519), Expect = 6e-52
Identities = 120/303 (39%), Positives = 178/303 (58%), Gaps = 19/303 (6%)
Query: 76 DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
DF LKVIG+G+FG+V + + K + +A+K+L K +LK+ E ER+VL+ N +
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170
Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
++ LH++FQ + LY V+DY GG+L L + E E ARFY AE+ A+ +H
Sbjct: 171 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 229
Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
L+ V+RD+KP+NIL+D GHI L DFG C + +E + S+ GTP+Y++PE+L
Sbjct: 230 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC-GTPEYLAPEVLH---- 284
Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQV-TDVSEN 313
K Y DWW LG +YEMLYG PFY+ + E Y I+N P Q+ +++ +
Sbjct: 285 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK------PLQLKPNITNS 337
Query: 314 AKDLIRRLI-CSREHRLG-QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPEVSSPTDTS 369
A+ L+ L+ R RLG ++ + K H FFS I+WD++ N P+ P VS P D
Sbjct: 338 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 397
Query: 370 NFD 372
+FD
Sbjct: 398 HFD 400
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 204 bits (519), Expect = 6e-52
Identities = 120/303 (39%), Positives = 178/303 (58%), Gaps = 19/303 (6%)
Query: 76 DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
DF LKVIG+G+FG+V + + K + +A+K+L K +LK+ E ER+VL+ N +
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
++ LH++FQ + LY V+DY GG+L L + E E ARFY AE+ A+ +H
Sbjct: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 243
Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
L+ V+RD+KP+NIL+D GHI L DFG C + +E + S+ GTP+Y++PE+L
Sbjct: 244 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC-GTPEYLAPEVLH---- 298
Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQV-TDVSEN 313
K Y DWW LG +YEMLYG PFY+ + E Y I+N P Q+ +++ +
Sbjct: 299 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK------PLQLKPNITNS 351
Query: 314 AKDLIRRLI-CSREHRLG-QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPEVSSPTDTS 369
A+ L+ L+ R RLG ++ + K H FFS I+WD++ N P+ P VS P D
Sbjct: 352 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 411
Query: 370 NFD 372
+FD
Sbjct: 412 HFD 414
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 204 bits (519), Expect = 6e-52
Identities = 120/303 (39%), Positives = 178/303 (58%), Gaps = 19/303 (6%)
Query: 76 DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
DF LKVIG+G+FG+V + + K + +A+K+L K +LK+ E ER+VL+ N +
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
++ LH++FQ + LY V+DY GG+L L + E E ARFY AE+ A+ +H
Sbjct: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 310
Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
L+ V+RD+KP+NIL+D GHI L DFG C + +E + S+ GTP+Y++PE+L
Sbjct: 311 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC-GTPEYLAPEVLH---- 365
Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQV-TDVSEN 313
K Y DWW LG +YEMLYG PFY+ + E Y I+N P Q+ +++ +
Sbjct: 366 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK------PLQLKPNITNS 418
Query: 314 AKDLIRRLI-CSREHRLG-QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPEVSSPTDTS 369
A+ L+ L+ R RLG ++ + K H FFS I+WD++ N P+ P VS P D
Sbjct: 419 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 478
Query: 370 NFD 372
+FD
Sbjct: 479 HFD 481
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 204 bits (519), Expect = 6e-52
Identities = 116/303 (38%), Positives = 182/303 (60%), Gaps = 20/303 (6%)
Query: 75 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDN 134
EDFE K +G G+FG V +VK K ++ +AMKIL+K +++K + E+ +L +
Sbjct: 89 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148
Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
++ L YAF+D++NLY+VM+Y GG++ + L + R E ARFY A++V+ + +H
Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHS 207
Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
L ++RD+KP+N+L+D G+I++ DFG ++ ++ GTP+Y++PEI+ +
Sbjct: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILS--- 260
Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENA 314
KG Y DWW+LGV +YEM G PF+A+ ++ Y KI++ K RF + S +
Sbjct: 261 -KG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP-----SHFSSDL 313
Query: 315 KDLIRRLI-CSREHRLG--QNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTS 369
KDL+R L+ R G +NG+ D K H +F+ DW I R EAP+IP+ DTS
Sbjct: 314 KDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTS 373
Query: 370 NFD 372
NFD
Sbjct: 374 NFD 376
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 204 bits (518), Expect = 8e-52
Identities = 140/380 (36%), Positives = 210/380 (55%), Gaps = 35/380 (9%)
Query: 77 FEILKVIGRGAFGEVAVVKL---KNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 133
FE+LKV+G+G+FG+V +VK +A +++AMK+L K LK + + ERD+LV +
Sbjct: 68 FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKK-ATLKVRDRVRTKMERDILVEVN 126
Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193
+ +I LHYAFQ + LYL++D+ GGDL T LSK E E+ +FYLAE+ +A+D +H
Sbjct: 127 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 185
Query: 194 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 253
L ++RD+KP+NIL+D GHI+L DFG K D ++ GT +Y++PE++
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFG-LSKESIDHEKKAYSFCGTVEYMAPEVV---- 240
Query: 254 DGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSEN 313
+ + DWWS GV M+EML G PF + ET I+ K + P +S
Sbjct: 241 -NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL--KAKLGMP---QFLSPE 294
Query: 314 AKDLIRRLI-CSREHRL--GQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDT 368
A+ L+R L + +RL G +G+E+ K+H FFS IDW+ + R P+ P P DT
Sbjct: 295 AQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDT 354
Query: 369 SNFDVDDDCL--KNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLD 426
FD + K+S +PP + H F GF++ + D S T G S+
Sbjct: 355 FYFDPEFTAKTPKDSPGIPPSANA-----HQLFRGFSFV-AITSDDESQAMQTVGVHSI- 407
Query: 427 LDVNVQRTLDNNLA-TEAYE 445
VQ+ N++ T+ YE
Sbjct: 408 ----VQQLHRNSIQFTDGYE 423
Score = 90.9 bits (224), Expect = 1e-17
Identities = 87/296 (29%), Positives = 146/296 (49%), Gaps = 35/296 (11%)
Query: 71 RLHR------EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFRE 124
+LHR + +E+ + IG G++ K + FA+KI++K KR T E
Sbjct: 410 QLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDK---SKRDPT----E 462
Query: 125 ERDVLVN-GDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLA 183
E ++L+ G + I TL + D +Y+V + GG+LL + + + E A L
Sbjct: 463 EIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILR-QKFFSEREASAVLF 521
Query: 184 EMVIAIDSVHQLHYVHRDIKPDNIL-MDMNGH---IRLADFGSCLKLM-EDGTVQSSVAV 238
+ ++ +H VHRD+KP NIL +D +G+ IR+ DFG +L E+G + +
Sbjct: 522 TITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY- 580
Query: 239 GTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
T ++++PE+L+ + Y CD WSLGV +Y ML G TPF A +T +I+
Sbjct: 581 -TANFVAPEVLK-----RQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARI 633
Query: 299 ERFQFP---AQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNI 351
+F VS+ AKDL+ +++ H+ + +HP+ + WD +
Sbjct: 634 GSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAAL--VLRHPWI--VHWDQL 685
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 203 bits (517), Expect = 1e-51
Identities = 126/349 (36%), Positives = 195/349 (55%), Gaps = 23/349 (6%)
Query: 71 RLHREDFEILKVIGRGAFGEVAVVKL---KNADKVFAMKILNKWEMLKRA-ETACFREER 126
++ E FE+L+V+G+G +G+V V+ N K+FAMK+L K +++ A +TA + ER
Sbjct: 85 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 144
Query: 127 DVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMV 186
++L + +I L YAFQ LYL+++Y GG+L L + E ED A FYLAE+
Sbjct: 145 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLER-EGIFMEDTACFYLAEIS 203
Query: 187 IAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISP 246
+A+ +HQ ++RD+KP+NI+++ GH++L DFG C + + DGTV + GT +Y++P
Sbjct: 204 MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC-GTIEYMAP 262
Query: 247 EILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQ 306
EIL M G R DWWSLG MY+ML G PF E+ +T KI+ K + P
Sbjct: 263 EIL--MRSGHNR---AVDWWSLGALMYDMLTGAPPFTGENRKKTIDKIL--KCKLNLPPY 315
Query: 307 VTDVSENAKDLIRRLI---CSREHRLGQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPE 361
+T + A+DL+++L+ + G + + HPFF I+W+ + R E P+ P
Sbjct: 316 LT---QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPL 372
Query: 362 VSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVL 410
+ S D S F D + + P T + F+GFTY + VL
Sbjct: 373 LQSEEDVSQF--DSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVL 419
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 202 bits (514), Expect = 2e-51
Identities = 127/356 (35%), Positives = 202/356 (56%), Gaps = 28/356 (7%)
Query: 77 FEILKVIGRGAFGEVAVVKL---KNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 133
FE+LKV+G+G+FG+V +V+ ++ ++AMK+L K LK + + ERD+L + +
Sbjct: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK-ATLKVRDRVRTKMERDILADVN 129
Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193
+ ++ LHYAFQ + LYL++D+ GGDL T LSK E E+ +FYLAE+ + +D +H
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALGLDHLH 188
Query: 194 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 253
L ++RD+KP+NIL+D GHI+L DFG + + D ++ GT +Y++PE++
Sbjct: 189 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV---- 243
Query: 254 DGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSEN 313
+ + DWWS GV M+EML G PF + ET I+ K + P +S
Sbjct: 244 -NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL--KAKLGMP---QFLSTE 297
Query: 314 AKDLIRRLI-CSREHRLGQ--NGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDT 368
A+ L+R L + +RLG +G E+ K+H F+S IDW+ + R + P+ P V+ P DT
Sbjct: 298 AQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDT 357
Query: 369 SNFDVD--DDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGP 422
FD + K+S +PP +G H F GF++ ++ ++ D R P
Sbjct: 358 FYFDTEFTSRTPKDSPGIPPS-----AGAHQLFRGFSFVATGLMEDDGKPRAPQAP 408
Score = 94.0 bits (232), Expect = 1e-18
Identities = 82/280 (29%), Positives = 142/280 (50%), Gaps = 29/280 (10%)
Query: 62 PFTSKVKQMR----LHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRA 117
P S V+Q+ + + + + + IG G++ E K + +A+K+++K KR
Sbjct: 408 PLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK---SKRD 464
Query: 118 ETACFREERDVLVN-GDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176
+ EE ++L+ G + I TL + D ++YLV + GG+LL + + + E
Sbjct: 465 PS----EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR-QKFFSER 519
Query: 177 MARFYLAEMVIAIDSVHQLHYVHRDIKPDNIL-MDMNGH---IRLADFGSCLKLM-EDGT 231
A F L + ++ +H VHRD+KP NIL +D +G+ +R+ DFG +L E+G
Sbjct: 520 EASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGL 579
Query: 232 VQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETY 291
+ + T ++++PE+L+ + Y CD WSLG+ +Y ML G TPF A +T
Sbjct: 580 LMTPCY--TANFVAPEVLK-----RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTP 631
Query: 292 GKIMNHKERFQFP---AQVTDVSENAKDLIRRLICSREHR 328
+I+ +F VSE AKDL+ +++ H+
Sbjct: 632 EEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQ 671
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,677,867
Number of Sequences: 37866
Number of extensions: 3183457
Number of successful extensions: 33770
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 989
Number of HSP's successfully gapped in prelim test: 1664
Number of HSP's that attempted gapping in prelim test: 14316
Number of HSP's gapped (non-prelim): 9663
length of query: 1719
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1603
effective length of database: 13,855,062
effective search space: 22209664386
effective search space used: 22209664386
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.