Search of human proteins with 29837648

Search of human proteins with 29837648

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide
1 [Homo sapiens]
         (509 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...  1054   0.0  
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        572   e-163
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   501   e-142
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   489   e-138
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   477   e-135
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   472   e-133
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   416   e-116
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   410   e-114
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   410   e-114
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   397   e-111
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   397   e-110
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   387   e-107
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   374   e-104
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   276   3e-74
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   167   2e-41
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   163   3e-40
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   159   6e-39
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   153   3e-37
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   152   7e-37
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   132   7e-31
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   132   7e-31
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ...   123   5e-28
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   119   9e-27
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  116   6e-26
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   115   9e-26
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid...   114   3e-25
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   105   1e-22
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   103   3e-22
gi|239757171 PREDICTED: similar to cytochrome P450, family 4, su...   103   5e-22
gi|239751683 PREDICTED: similar to cytochrome P450, family 4, su...   103   5e-22

>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score = 1054 bits (2726), Expect = 0.0
 Identities = 509/509 (100%), Positives = 509/509 (100%)

Query: 1   MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 60
           MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF
Sbjct: 1   MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 60

Query: 61  IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL 120
           IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL
Sbjct: 61  IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL 120

Query: 121 LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEV 180
           LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEV
Sbjct: 121 LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEV 180

Query: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240
           YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL
Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

Query: 241 SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS 300
           SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS
Sbjct: 241 SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS 300

Query: 301 FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ 360
           FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ
Sbjct: 301 FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ 360

Query: 361 LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW 420
           LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW
Sbjct: 361 LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW 420

Query: 421 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD 480
           KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD
Sbjct: 421 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD 480

Query: 481 PTRPLTFPNHFILKPKNGMYLHLKKLSEC 509
           PTRPLTFPNHFILKPKNGMYLHLKKLSEC
Sbjct: 481 PTRPLTFPNHFILKPKNGMYLHLKKLSEC 509


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  572 bits (1473), Expect = e-163
 Identities = 271/506 (53%), Positives = 372/506 (73%), Gaps = 2/506 (0%)

Query: 1   MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 60
           ME SWL+   A PF L  + C++L L Q I+LY RR+ ++R L  FPAPP HWF GH++F
Sbjct: 1   MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEF 60

Query: 61  IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL 120
                 E   +++EKYP A P W+GPF  FF ++DPDYAK LL R DPKS    K     
Sbjct: 61  YPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESW 120

Query: 121 LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEV 180
           +G+GL  LDG KW +HR+++ PGF+ +ILK +I +M+ SV+MML+KWE+  + Q++ +E+
Sbjct: 121 VGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIA-QNSRLEL 179

Query: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240
           ++H++ M+LD IMKCAFS + + Q +ST D Y KA+F LSKI   R+ + L+H+D++FK 
Sbjct: 180 FQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKF 239

Query: 241 SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS 300
           S QG  F K ++ L+Q+T+ +IQ+RK+SL+  +KQD T KR++ DFLDI+LSAK E+   
Sbjct: 240 SSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRW-DFLDILLSAKSENTKD 298

Query: 301 FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ 360
           FS+ D+ +EV TF+ AGHDT +++ISWILYCLA  PEHQ+RCR+E+R +LGDGSSITW+ 
Sbjct: 299 FSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEH 358

Query: 361 LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW 420
           L +M YTTMCIKE  RL   V +ISR L KP+TFPDG +LPAGITV ++IW LHHNP  W
Sbjct: 359 LSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFW 418

Query: 421 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD 480
           ++P+VF+PLRFS+ENS++ HPYA++PFSAG RNCIGQ FA+IE KV +AL LL F++ PD
Sbjct: 419 EDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPD 478

Query: 481 PTRPLTFPNHFILKPKNGMYLHLKKL 506
            +RP       +LK KNG+++  KK+
Sbjct: 479 HSRPPQPVRQVVLKSKNGIHVFAKKV 504


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  501 bits (1290), Expect = e-142
 Identities = 243/491 (49%), Positives = 343/491 (69%), Gaps = 4/491 (0%)

Query: 17  AFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGH-QKFIQDDNMEKLEEIIEK 75
           A +  L L L++A++LYL RQ LL+ L+ FP PP+HW  GH Q+  QD  ++++++ +E 
Sbjct: 22  ASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVET 81

Query: 76  YPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQ 135
           +P A P W+   +    +YDPDY K +L R+DPKS    +F  P +G GL  L+G  WFQ
Sbjct: 82  FPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQ 141

Query: 136 HRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKC 195
           HRR+LTP FH++ILK Y+ +MA SV++MLDKWE++   QD+ +EV++H++ M+LD IMKC
Sbjct: 142 HRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLG-QDSPLEVFQHVSLMTLDTIMKC 200

Query: 196 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 255
           AFS + + Q +     Y +AI +L+ ++F R+ +  + +D I+ L+  G    +  ++ +
Sbjct: 201 AFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAH 260

Query: 256 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 315
           Q+TD +IQ RK  LQ   + +   ++++ DFLDI+L AK E+GS  SD D+ +EV TF+ 
Sbjct: 261 QHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMF 320

Query: 316 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETC 375
            GHDT A+ ISWILY LA +P+HQERCREE+  +LGDG+SITW+ L +M YTTMCIKE  
Sbjct: 321 EGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEAL 380

Query: 376 RLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 435
           RL P VP I R+LS P+TFPDG +LP GI V+LSI+GLHHNP VW NP+VFDP RF+  +
Sbjct: 381 RLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS 440

Query: 436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKP 495
           +  +H +A+LPFS GSRNCIG++FAM ELKV  AL LL F + PDPTR        +LK 
Sbjct: 441 A--QHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKS 498

Query: 496 KNGMYLHLKKL 506
           KNG++L L++L
Sbjct: 499 KNGIHLRLRRL 509


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  489 bits (1259), Expect = e-138
 Identities = 241/486 (49%), Positives = 338/486 (69%), Gaps = 4/486 (0%)

Query: 22  LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGH-QKFIQDDNMEKLEEIIEKYPRAF 80
           L L L++A +LYL RQ LL+ L+ FP PP+HW  GH Q+F  D  +++++E ++ +P A 
Sbjct: 27  LLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSAC 86

Query: 81  PFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLL 140
           P+WI   +    +YDPDY K +L R+DPKS    KF  P +G GL  L+G  WFQHRR+L
Sbjct: 87  PYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRML 146

Query: 141 TPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKE 200
           TP FH +ILK Y+ +MA SV++MLDKWE++   QD+ +EV++H++ M+LD IMK AFS +
Sbjct: 147 TPAFHNDILKPYVGLMADSVRVMLDKWEELLG-QDSPLEVFQHVSLMTLDTIMKSAFSHQ 205

Query: 201 TNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDT 260
            + Q +     Y +AI +L+ ++F  + +  + +D I+ L+  G    +  ++ +Q+TD 
Sbjct: 206 GSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQ 265

Query: 261 IIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDT 320
           +IQ RK  LQ   + +   ++++ DFLDI+L AK E+GS  SD D+ +EV TF+  GHDT
Sbjct: 266 VIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 321 LAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPA 380
            A+ ISWILY LA +P+HQERCREE+ G+LGDG+SITW+ L +M YTTMCIKE  RL P 
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPP 385

Query: 381 VPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRH 440
           VP I R+LS P+TFPDG +LP GI V+LSI+GLHHNP VW N +VFDP RF+  ++  +H
Sbjct: 386 VPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSA--QH 443

Query: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 500
            +A+LPFS GSRNCIG++FAM +LKV  AL LL F + PDPTR        +LK KNG++
Sbjct: 444 SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIH 503

Query: 501 LHLKKL 506
           L L++L
Sbjct: 504 LRLRRL 509


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  477 bits (1228), Expect = e-135
 Identities = 234/487 (48%), Positives = 320/487 (65%), Gaps = 4/487 (0%)

Query: 22  LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDD-NMEKLEEIIEKYPRAF 80
           L LG L+ I L LRRQ L + +  FP PPTHW  GH   IQ+  +++K+     ++P A 
Sbjct: 22  LVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAH 81

Query: 81  PFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLL 140
           P W G F  F  IY+PDYAK + SR DPK+  +  F    +G+GL  L+GPKW QHR+LL
Sbjct: 82  PLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLL 141

Query: 141 TPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKE 200
           TPGFH+++LK Y+ V   S ++MLDKWE+  + +  S +++  +  M+L+ +MKC F + 
Sbjct: 142 TPGFHYDVLKPYVAVFTESTRIMLDKWEEK-AREGKSFDIFCDVGHMALNTLMKCTFGRG 200

Query: 201 TNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDT 260
                +S    Y  A+ +L+ ++  RL S  YH+D I+ L+P G RF +  +V + +TD 
Sbjct: 201 DTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQ 260

Query: 261 IIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDT 320
           +I+ERK +LQ    +     R++ DFLDI+L A+DE     SD D+ +EV TF+  GHDT
Sbjct: 261 VIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDT 320

Query: 321 LAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPA 380
             + ISW LYC+AL PEHQ RCREEVR ILGD     WD LG+M+Y TMCIKE+ RL P 
Sbjct: 321 TTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPP 380

Query: 381 VPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRH 440
           VP + R LSKP+TF DG +LPAG  + + I+ LH N AVW +P+VFD LRFS EN+ +RH
Sbjct: 381 VPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRH 440

Query: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR-PLTFPNHFILKPKNGM 499
           P+A++PFSAG RNCIGQ+FAM E+KV  A+ LL F  + DP+R P+  P   +L+ KNG 
Sbjct: 441 PFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGF 499

Query: 500 YLHLKKL 506
           +LHLK L
Sbjct: 500 HLHLKPL 506


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  472 bits (1215), Expect = e-133
 Identities = 235/489 (48%), Positives = 320/489 (65%), Gaps = 9/489 (1%)

Query: 22  LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDD-NMEKLEEIIEKYPRAF 80
           L LG L+ I L LRRQ L + +  FP PPTHW  GH   IQ+  +++K+     ++P A 
Sbjct: 22  LVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAH 81

Query: 81  PFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLL 140
           P W G F  F  IY+PDYAK + SR DPK+  +  F    +G+GL  L+GPKW QHR+LL
Sbjct: 82  PLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLL 141

Query: 141 TPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKE 200
           TPGFH+++LK Y+ V   S ++MLDKWE+  + +  S +++  +  M+L+ +MKC F + 
Sbjct: 142 TPGFHYDVLKPYVAVFTESTRIMLDKWEEK-AREGKSFDIFCDVGHMALNTLMKCTFGRG 200

Query: 201 TNCQTNSTH--DPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYT 258
               T   H    Y  A+ +L+ ++  RL S  YH+D I+ L+P G RF +  +V + +T
Sbjct: 201 ---DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHT 257

Query: 259 DTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGH 318
           D +I+ERK +LQ    +     R++ DFLDI+L A+DE     SD D+ +EV TF+  GH
Sbjct: 258 DQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGH 317

Query: 319 DTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLI 378
           DT  + ISW LYC+AL PEHQ RCREEVR ILGD     WD LG+M+Y TMCIKE+ RL 
Sbjct: 318 DTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLY 377

Query: 379 PAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQ 438
           P VP + R LSKP+TF DG +LPAG  + + I+ LH N AVW +P+VFD LRFS EN+ +
Sbjct: 378 PPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASK 437

Query: 439 RHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR-PLTFPNHFILKPKN 497
           RHP+A++PFSAG RNCIGQ+FAM E+KV  A+ LL F  + DP+R P+  P   +L+ KN
Sbjct: 438 RHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKN 496

Query: 498 GMYLHLKKL 506
           G +LHLK L
Sbjct: 497 GFHLHLKPL 505


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  416 bits (1070), Expect = e-116
 Identities = 204/478 (42%), Positives = 302/478 (63%), Gaps = 14/478 (2%)

Query: 41  RDLRPFPAPPT-HWFLGHQKFIQ--DDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPD 97
           R LR FP PP  +WF GHQ  +   ++ M  L +++  YP+ F  W+GP      +  PD
Sbjct: 46  RRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPD 105

Query: 98  YAKTLLSRTD---PKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIE 154
             +++++ +    PK ++   F  P LG GL    G KW +HRR+LTP FHFNILK Y++
Sbjct: 106 IIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMK 165

Query: 155 VMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAK 214
           +   SV +M  KW+ + S     ++++EHI+ M+LD + KC FS +++CQ   +   Y  
Sbjct: 166 IFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSE--YIA 223

Query: 215 AIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVK 274
           AI ELS ++  R + +L H D ++ L+P G RF++  R+++ +TD +IQER+++L +   
Sbjct: 224 AILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGV 283

Query: 275 QD---NTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYC 331
            D      K K  DF+D++L +KDE G   SD D+ +E  TF+  GHDT A+ +SW+LY 
Sbjct: 284 DDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYH 343

Query: 332 LALNPEHQERCREEVRGILGDGS--SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLS 389
           LA +PE+QERCR+EV+ +L D     I WD L  + + TMC+KE+ RL P VP ISR ++
Sbjct: 344 LAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVT 403

Query: 390 KPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSA 449
           + +  PDG  +P GI  ++S++G HHNPAVW +P+V+DP RF  EN  +R P A++PFSA
Sbjct: 404 QDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSA 463

Query: 450 GSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLS 507
           G RNCIGQ FAM E+KV +AL LL FRV PD T P   P   +L+ + G++L ++ LS
Sbjct: 464 GPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKP-ELVLRAEGGLWLRVEPLS 520


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  410 bits (1055), Expect = e-114
 Identities = 205/477 (42%), Positives = 296/477 (62%), Gaps = 14/477 (2%)

Query: 41  RDLRPFPAPPT-HWFLGHQKFIQ--DDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPD 97
           R L+ FP PP  +WF GHQ  +   ++ M+ L +++  YP+ F  W+GP      +  PD
Sbjct: 46  RRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPD 105

Query: 98  YAKTLLSRTD---PKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIE 154
             + + S +    PK      F  P LG GL    G KW +HRR+LTP FHFNILK Y++
Sbjct: 106 IIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMK 165

Query: 155 VMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAK 214
           +   SV +M DKW+++ S     ++++EHI+ M+LD + KC FS E+NCQ   +   Y  
Sbjct: 166 IFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSE--YIA 223

Query: 215 AIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVK 274
           AI ELS  +  R   +L H+D ++ L+P G RF++   +++ +TD +IQER+ +L     
Sbjct: 224 AILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGI 283

Query: 275 QD---NTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYC 331
            D   N  K K  DF+D++L +KDE G   SD D+ +E  TF+  GHDT A+ +SW+LY 
Sbjct: 284 DDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYH 343

Query: 332 LALNPEHQERCREEVRGILGDGS--SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLS 389
           LA +PE+QE+CR+EV+ +L D     I WD L ++ + TMCIKE+ RL P VP ISR  +
Sbjct: 344 LAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCT 403

Query: 390 KPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSA 449
           +    PDG  +P GI  +++I G+H+NP VW +P+V+DP RF QEN  +R P A++PFSA
Sbjct: 404 QDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSA 463

Query: 450 GSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKL 506
           G RNCIGQ FAM E+KV +AL LLHFR+ P  T P   P   IL+ + G++L ++ L
Sbjct: 464 GPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKP-ELILRAEGGLWLRVEPL 519


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  410 bits (1055), Expect = e-114
 Identities = 205/477 (42%), Positives = 296/477 (62%), Gaps = 14/477 (2%)

Query: 41  RDLRPFPAPPT-HWFLGHQKFIQ--DDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPD 97
           R L+ FP PP  +WF GHQ  +   ++ M+ L +++  YP+ F  W+GP      +  PD
Sbjct: 46  RRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPD 105

Query: 98  YAKTLLSRTD---PKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIE 154
             + + S +    PK      F  P LG GL    G KW +HRR+LTP FHFNILK Y++
Sbjct: 106 IIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMK 165

Query: 155 VMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAK 214
           +   SV +M DKW+++ S     ++++EHI+ M+LD + KC FS E+NCQ   +   Y  
Sbjct: 166 IFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSE--YIA 223

Query: 215 AIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVK 274
           AI ELS  +  R   +L H+D ++ L+P G RF++   +++ +TD +IQER+ +L     
Sbjct: 224 AILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGI 283

Query: 275 QD---NTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYC 331
            D   N  K K  DF+D++L +KDE G   SD D+ +E  TF+  GHDT A+ +SW+LY 
Sbjct: 284 DDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYH 343

Query: 332 LALNPEHQERCREEVRGILGDGS--SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLS 389
           LA +PE+QE+CR+EV+ +L D     I WD L ++ + TMCIKE+ RL P VP ISR  +
Sbjct: 344 LAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCT 403

Query: 390 KPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSA 449
           +    PDG  +P GI  +++I G+H+NP VW +P+V+DP RF QEN  +R P A++PFSA
Sbjct: 404 QDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSA 463

Query: 450 GSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKL 506
           G RNCIGQ FAM E+KV +AL LLHFR+ P  T P   P   IL+ + G++L ++ L
Sbjct: 464 GPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKP-ELILRAEGGLWLRVEPL 519


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  397 bits (1021), Expect = e-111
 Identities = 198/478 (41%), Positives = 296/478 (61%), Gaps = 14/478 (2%)

Query: 41  RDLRPFPAPPT-HWFLGHQKFIQ--DDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPD 97
           R L+ FP PP  +WF GH   I   ++ ++   ++   Y + F  W+GP   F  +  PD
Sbjct: 46  RRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPD 105

Query: 98  YAKTLLSRTD---PKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIE 154
             +++ + +    PK     +F  P LG+G+    G KW +HRR+LTP FHFNILK+YI 
Sbjct: 106 TIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYIT 165

Query: 155 VMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAK 214
           +   S  +MLDKW+ + S   + ++++EHI+ M+LD + KC FS +++CQ   +   Y  
Sbjct: 166 IFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSE--YIA 223

Query: 215 AIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVK 274
            I ELS ++  R   +L H D ++ LS  G RF +  R+++ +TD +I+ER+++L     
Sbjct: 224 TILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGI 283

Query: 275 QD---NTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYC 331
            D   +  K K  DF+D++L +KDE G + SD D+ +E  TF+  GHDT A+ +SW+LY 
Sbjct: 284 DDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYN 343

Query: 332 LALNPEHQERCREEVRGILGDGS--SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLS 389
           LA +PE+QERCR+EV+ +L D     I WD L ++ + TMC+KE+ RL P  P ISR  +
Sbjct: 344 LARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCT 403

Query: 390 KPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSA 449
           + +  PDG  +P GIT ++ I G+HHNP VW +P+V+DP RF  ENS  R P A++PFSA
Sbjct: 404 QDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSA 463

Query: 450 GSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLS 507
           G RNCIGQ FAM E+KV +AL+LLHFR  PD T P       I++ + G++L ++ L+
Sbjct: 464 GPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRR-KLELIMRAEGGLWLRVEPLN 520


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  397 bits (1020), Expect = e-110
 Identities = 200/476 (42%), Positives = 296/476 (62%), Gaps = 14/476 (2%)

Query: 43  LRPFPAPPT-HWFLGHQKFIQ--DDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYA 99
           LR FP PP  +WFLGH   I   ++ +   + +   +     +W+GP+ A   I+ P Y 
Sbjct: 48  LRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYI 107

Query: 100 KTLL---SRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVM 156
           K +L   +   PK +    F  P LG GL    G KW +HRR+LTP FHFNILK Y+++ 
Sbjct: 108 KPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIF 167

Query: 157 AHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAI 216
             SV +M  KW+ + S     ++++EHI+ M+LD + KC FS +++CQ   +   Y  AI
Sbjct: 168 NESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSE--YIAAI 225

Query: 217 FELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQD 276
            ELS ++  R   +L + D ++ L+P G RF++  R+++ +TD +IQER+++L +    D
Sbjct: 226 LELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDD 285

Query: 277 ---NTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLA 333
                 K K  DF+D++L +KDE G   SD D+ +E  TF+  GHDT A+ +SW+LY LA
Sbjct: 286 FLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLA 345

Query: 334 LNPEHQERCREEVRGILGDGS--SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKP 391
            +PE+QERCR+EV+ +L D     I WD L ++ + TMCIKE+ RL P VP++SR  ++ 
Sbjct: 346 KHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQD 405

Query: 392 LTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGS 451
           +  PDG  +P GI  ++S++G HHNPAVW +P+V+DP RF  +N  +R P A++PFSAG 
Sbjct: 406 IVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGP 465

Query: 452 RNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLS 507
           RNCIGQ FAM E+KV + L LL FRV PD T P   P   +L+ + G++L ++ LS
Sbjct: 466 RNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKP-ELVLRAEGGLWLRVEPLS 520


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  387 bits (995), Expect = e-107
 Identities = 200/519 (38%), Positives = 308/519 (59%), Gaps = 16/519 (3%)

Query: 1   MEFSWLETR--WARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAP-PTHWFLGH 57
           +  SWL  R   A P+ L  V   +  L + +          R LR FP P   +WFLGH
Sbjct: 4   LSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGH 63

Query: 58  QKFIQ--DDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDP---KSQY 112
              +   ++ +  L +++  YP+ F  W+GP      +  PD  +++++ +D    K   
Sbjct: 64  LGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIV 123

Query: 113 LQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICS 172
             K   P LG GL    G KW  HRRLLTP FHFNILK YI++ + S  +M  KW+++  
Sbjct: 124 FYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAM 183

Query: 173 TQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLY 232
              T ++V+EHI+ M+LD + KC FS ++NCQ   +   Y  AI ELS ++  R      
Sbjct: 184 EGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSE--YITAIMELSALVVKRNNQFFR 241

Query: 233 HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQD---NTPKRKYQDFLDI 289
           + D ++ L+P G RF +  R+++ +TD +IQER+++L +    D      K K  DF+D+
Sbjct: 242 YKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDV 301

Query: 290 VLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGI 349
           +L ++D++G   SD D+ +E  TF+  GHDT A+ +SW+LY LA +PE+QERCR+EV+ +
Sbjct: 302 LLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361

Query: 350 LGDGS--SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVV 407
           L D     I WD L ++ + TMC+KE+ RL P +P+ +R  ++ +  PD   +P G    
Sbjct: 362 LKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCN 421

Query: 408 LSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVT 467
           ++I+ +HHNP+VW +P+V+DP RF  EN+ +R P A++PFSAG RNCIGQ+FAM E+KV 
Sbjct: 422 INIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVV 481

Query: 468 IALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKL 506
           +AL LL FR+ PD   P   P   +L+ ++G++L ++ L
Sbjct: 482 LALTLLRFRILPDHREPRRTP-EIVLRAEDGLWLRVEPL 519


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  374 bits (961), Expect = e-104
 Identities = 200/503 (39%), Positives = 295/503 (58%), Gaps = 15/503 (2%)

Query: 14  FYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPT-HWFLGHQKFI--QDDNMEKLE 70
           F L F+F L L  L+  + +       R LR FP PP  +W LGH       +  ++  +
Sbjct: 30  FLLFFLFRLLLRFLRLCRSFYIT---CRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEK 86

Query: 71  EIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTD---PKSQYLQKFSPPLLGKGLAA 127
           ++++        W+GP      +  PDY K LL  +    PK      F  P LG GL  
Sbjct: 87  KVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLL 146

Query: 128 LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSM 187
             G KW +HRRLLTP FHF+ILK Y+++   S  +M  KW  +      S++++EHI+ M
Sbjct: 147 SKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLM 206

Query: 188 SLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRF 247
           +LD + KC FS  +NCQ   +   Y  AI ELS +   R Y L ++ D I+  S  G RF
Sbjct: 207 TLDSLQKCVFSYNSNCQEKMSD--YISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRF 264

Query: 248 QKLSRVLNQYTDTIIQERKKSL-QAGVKQDNTPKR-KYQDFLDIVLSAKDESGSSFSDID 305
           ++   +++ +T  +IQER+++L Q G +     K+ K  DF+D++L A+DE G   SD D
Sbjct: 265 RQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDED 324

Query: 306 VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILG--DGSSITWDQLGE 363
           + +E  TF+  GHDT ++ ISW+L+ LA  PE+QE+CREE++ ++   +   + WD L +
Sbjct: 325 IRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQ 384

Query: 364 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNP 423
           + +TTMCIKE+ R  P V  +SR  ++ +  PDG  +P GI  ++SI+G HHNP VW + 
Sbjct: 385 LPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDS 444

Query: 424 KVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR 483
           KV++P RF  +N  QR P AY+PFSAG RNCIGQ FAM EL+V +AL LL FR++ D TR
Sbjct: 445 KVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTR 504

Query: 484 PLTFPNHFILKPKNGMYLHLKKL 506
            +      IL+ +NG++L ++ L
Sbjct: 505 KVRRKPELILRTENGLWLKVEPL 527


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  276 bits (706), Expect = 3e-74
 Identities = 168/501 (33%), Positives = 270/501 (53%), Gaps = 27/501 (5%)

Query: 22  LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHW-FLGHQKFIQDDNMEKLEEIIE-----K 75
           L L LLQ +  Y R+ +    +RP P     +  +GH   ++ D  E  ++IIE     +
Sbjct: 29  LVLSLLQRVASYARKWQ---QMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYR 85

Query: 76  YPRAFPFWIGPFQAFFCIYDPDYAKTLLSRT---DPKSQYLQKFSPPLLGKGLAALDGPK 132
           +      W+GP      +Y+ +  + +L+ +   D  S Y  KF  P LG GL    G K
Sbjct: 86  HMPLLKLWVGPVP-MVALYNAENVEVILTSSKQIDKSSMY--KFLEPWLGLGLLTSTGNK 142

Query: 133 WFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDII 192
           W   R++LTP FHF IL+ ++++M     +++ K EK  + +  +   + +I   +LDII
Sbjct: 143 WRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQE--AFNCFFYITLCALDII 200

Query: 193 MKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSR 252
            + A  K    Q+N   + Y +A++ +S++IF R+       D+ + +  +G+  +K  +
Sbjct: 201 CETAMGKNIGAQSNDDSE-YVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQ 259

Query: 253 VLNQYTDTIIQERKKSLQA-----GVKQDNTP-KRKYQDFLDIVLSAKDESGSSFSDIDV 306
           +L+ +T+++I ER   + A     G  + + P K K + FLD++LS  D+ G+  S  D+
Sbjct: 260 ILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDI 319

Query: 307 HSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMS 365
             EV TF+  GHDT AA+I+W LY L  NPE Q++   E+  + G      T + L ++ 
Sbjct: 320 REEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLR 379

Query: 366 YTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKV 425
           Y    IKET RL P+VP  +R +S+      G  +  G   V+  + LH +P  + NP+ 
Sbjct: 380 YLECVIKETLRLFPSVPLFARSVSEDCEVA-GYRVLKGTEAVIIPYALHRDPRYFPNPEE 438

Query: 426 FDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR-P 484
           F P RF  EN+  RHPYAY+PFSAG RNCIGQ+FA++E K  ++ IL HF +  +  R  
Sbjct: 439 FQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREE 498

Query: 485 LTFPNHFILKPKNGMYLHLKK 505
           L      IL+P NG+++ LK+
Sbjct: 499 LGLEGQLILRPSNGIWIKLKR 519


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  167 bits (424), Expect = 2e-41
 Identities = 128/469 (27%), Positives = 224/469 (47%), Gaps = 22/469 (4%)

Query: 47  PAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRT 106
           P P    FLG   F          E  EKY   +  + G  Q    I DPD  KT+L + 
Sbjct: 39  PGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQ-QPMLVIMDPDMIKTVLVKE 97

Query: 107 DPKSQYLQKFSPPL--LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMML 164
                  Q    P+  L   L+  +  +W + R LL+P F     K  + +++    M++
Sbjct: 98  CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV 157

Query: 165 DKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIF 224
               +       S+ + +   + ++D+I    F    +   N+  DP+ K + +L K+ F
Sbjct: 158 RSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLD-SLNNPQDPFLKNMKKLLKLDF 215

Query: 225 HRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRK-- 282
              + LL    +   L+P    F+ L+  +  +   +    K S++   +     K+K  
Sbjct: 216 LDPFLLLI--SLFPFLTPV---FEALN--IGLFPKDVTHFLKNSIERMKESRLKDKQKHR 268

Query: 283 ---YQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
              +Q  +D   S + +S  + SD+++ ++    + A +DT + ++ +I+Y LA +P+ Q
Sbjct: 269 VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQ 328

Query: 340 ERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCT 399
           ++ +EE+  +L + + +T+D L +M Y  M + ET RL P V  ++R   K +   +G  
Sbjct: 329 QKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVF 387

Query: 400 LPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEF 459
           +P G+ V++ I+ LHH+P  W  P+ F P RFS++N D    Y Y+PF AG RNCIG  F
Sbjct: 388 IPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRF 447

Query: 460 AMIELKVTIALILLHFRVTP--DPTRPLTFPNHFILKPKNGMYL--HLK 504
           A+  +K+ +   L +F   P  +   PL   N  IL+P+  + L  HL+
Sbjct: 448 ALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLR 496


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  163 bits (413), Expect = 3e-40
 Identities = 128/470 (27%), Positives = 224/470 (47%), Gaps = 23/470 (4%)

Query: 47  PAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRT 106
           P P    FLG   F          E  EKY   +  + G  Q    I DPD  KT+L + 
Sbjct: 39  PGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQ-QPMLVIMDPDMIKTVLVKE 97

Query: 107 DPKSQYLQKFSPPL--LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMML 164
                  Q    P+  L   L+  +  +W + R LL+P F     K  + +++    M++
Sbjct: 98  CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV 157

Query: 165 DKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIF 224
               +       S+ + +   + ++D+I    F    +   N+  DP+ K + +L K+ F
Sbjct: 158 RSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLD-SLNNPQDPFLKNMKKLLKLDF 215

Query: 225 HRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRK-- 282
              + LL    +   L+P    F+ L+  +  +   +    K S++   +     K+K  
Sbjct: 216 LDPFLLLI--SLFPFLTPV---FEALN--IGLFPKDVTHFLKNSIERMKESRLKDKQKHR 268

Query: 283 ---YQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
              +Q  +D   S + +S  + SD+++ ++    + A +DT + ++ +I+Y LA +P+ Q
Sbjct: 269 VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQ 328

Query: 340 ERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCT 399
           ++ +EE+  +L + + +T+D L +M Y  M + ET RL P V  ++R   K +   +G  
Sbjct: 329 QKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVF 387

Query: 400 LPAGITVVLSIWGLHHNPAVWKNPKVFDP-LRFSQENSDQRHPYAYLPFSAGSRNCIGQE 458
           +P G+ V++ I+ LHH+P  W  P+ F P  RFS++N D    Y Y+PF AG RNCIG  
Sbjct: 388 IPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMR 447

Query: 459 FAMIELKVTIALILLHFRVTP--DPTRPLTFPNHFILKPKNGMYL--HLK 504
           FA+  +K+ +   L +F   P  +   PL   N  IL+P+  + L  HL+
Sbjct: 448 FALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLR 497


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  159 bits (402), Expect = 6e-39
 Identities = 122/472 (25%), Positives = 232/472 (49%), Gaps = 30/472 (6%)

Query: 47  PAPPTHWFLG-----HQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKT 101
           P P    FLG     H+ F   D      E  +KY + + F+ G  Q    I DPD  KT
Sbjct: 39  PGPTPLPFLGNILSYHKGFCMFDM-----ECHKKYGKVWGFYDGQ-QPVLAITDPDMIKT 92

Query: 102 LLSRTDPKSQYLQK--FSPP-LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAH 158
           +L + +  S +  +  F P   +   ++  +  +W + R LL+P F    LK  + ++A 
Sbjct: 93  VLVK-ECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151

Query: 159 SVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFE 218
              +++    +   T    V + +   + S+D+I   +F    +   N+  DP+ +   +
Sbjct: 152 YGDVLVRNLRREAET-GKPVTLKDVFGAYSMDVITSTSFGVNID-SLNNPQDPFVENTKK 209

Query: 219 LSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNT 278
           L +  F   + L   S  +F           +     + T+ + +  K+  ++  + ++T
Sbjct: 210 LLRFDFLDPFFL---SITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES--RLEDT 264

Query: 279 PKRKYQDFLDIVLSAKD----ESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLAL 334
            K +  DFL +++ +++    ES  + SD+++ ++   F+ AG++T ++ +S+I+Y LA 
Sbjct: 265 QKHRV-DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323

Query: 335 NPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTF 394
           +P+ Q++ +EE+  +L + +  T+D + +M Y  M + ET RL P    + R   K +  
Sbjct: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383

Query: 395 PDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNC 454
            +G  +P G+ V++  + LH +P  W  P+ F P RFS++N D   PY Y PF +G RNC
Sbjct: 384 -NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442

Query: 455 IGQEFAMIELKVTIALILLHFRVTP--DPTRPLTFPNHFILKPKNGMYLHLK 504
           IG  FA++ +K+ +  +L +F   P  +   PL      +L+P+  + L ++
Sbjct: 443 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVE 494


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  153 bits (387), Expect = 3e-37
 Identities = 123/471 (26%), Positives = 226/471 (47%), Gaps = 31/471 (6%)

Query: 22  LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFP 81
           LA+ L+  + LY  R   L      P P    FLG+    +        E  +KY + + 
Sbjct: 15  LAVSLI-LLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG 73

Query: 82  FWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQK--FSPP-LLGKGLAALDGPKWFQHRR 138
            +    Q    I DPD  KT+L + +  S +  +  F P   +   ++  +  +W + R 
Sbjct: 74  IYDCQ-QPMLAITDPDMIKTVLVK-ECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRS 131

Query: 139 LLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFS 198
           LL+P F    LK  + ++A    +++    +   T    V +     + S+D+I   +F 
Sbjct: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAET-GKPVTLKHVFGAYSMDVITSTSFG 190

Query: 199 KETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYT 258
              +   N+  DP+ +   +L          L ++    F LS + + F  L+ +L    
Sbjct: 191 VSID-SLNNPQDPFVENTKKL----------LRFNPLDPFVLSIKVFPF--LTPILEALN 237

Query: 259 DTIIQERKKS-LQAGVKQDNTPKRKYQ-----DFLDIVLSAKD----ESGSSFSDIDVHS 308
            T+   +  S L   VKQ    + K       DFL +++ +++    E+  + SD+++ +
Sbjct: 238 ITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMA 297

Query: 309 EVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTT 368
           +   F+ AG++T ++ +S+I+Y LA +P+ Q++ ++E+  +L + +  T+D + ++ Y  
Sbjct: 298 QSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLD 357

Query: 369 MCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDP 428
           M + ET RL P    + R   K +   +G  +P G+ V++  + LHH+P  W  P+ F P
Sbjct: 358 MVVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLP 416

Query: 429 LRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP 479
            RFS++N D   PY Y PF +G RNCIG  FA++ +K+ +  +L +F   P
Sbjct: 417 ERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  152 bits (384), Expect = 7e-37
 Identities = 117/442 (26%), Positives = 220/442 (49%), Gaps = 25/442 (5%)

Query: 71  EIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLG---KGLAA 127
           E  +KY + +  + G       I DPD  +T+L + +  S +  + S   +G     ++ 
Sbjct: 63  ECYKKYGKMWGTYEGQLPVL-AITDPDVIRTVLVK-ECYSVFTNRRSLGPVGFMKSAISL 120

Query: 128 LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSM 187
            +  +W + R LL+P F    LK    ++A    +++    +    +   V + +   + 
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAE-KGKPVTLKDIFGAY 179

Query: 188 SLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK-LSPQGYR 246
           S+D+I   +F    +   N+  DP+ ++  +  K  F      L+ S I+F  L+P    
Sbjct: 180 SMDVITGTSFGVNID-SLNNPQDPFVESTKKFLKFGF---LDPLFLSIILFPFLTPV--- 232

Query: 247 FQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQ-DFLDIVLSAKD----ESGSSF 301
           F+ L+  ++ +    I    KS+    K     K+K++ DFL +++ +++    ES  + 
Sbjct: 233 FEALN--VSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKAL 290

Query: 302 SDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQL 361
           SD+++ ++   F+ AG++T ++ +S+ LY LA +P+ Q++ ++E+  +L + +  T+D +
Sbjct: 291 SDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAV 350

Query: 362 GEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWK 421
            +M Y  M + ET RL P    + R   K +   +G  +P G  VV+  + LHH+P  W 
Sbjct: 351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWT 409

Query: 422 NPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP-- 479
            P+ F P RFS++  D   PY Y PF  G RNCIG  FA++ +K+ +  +L +F   P  
Sbjct: 410 EPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 468

Query: 480 DPTRPLTFPNHFILKPKNGMYL 501
           +   PL      +L+P+  + L
Sbjct: 469 ETQIPLKLDTQGLLQPEKPIVL 490


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  132 bits (332), Expect = 7e-31
 Identities = 126/531 (23%), Positives = 227/531 (42%), Gaps = 69/531 (12%)

Query: 22  LALGLLQAIKLY----LRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYP 77
           L++ LL  +K Y      R   L    P P+P    F+G+  F +    E   E+ + Y 
Sbjct: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSP----FIGNLTFFRQGFWESQMELRKLYG 76

Query: 78  RAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAA----LDGPKW 133
               +++G  + F  I +PD  K +L   +  S +  + +  L  K +A     L   +W
Sbjct: 77  PLCGYYLGR-RMFIVISEPDMIKQVL--VENFSNFTNRMASGLEFKSVADSVLFLRDKRW 133

Query: 134 FQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIM 193
            + R  L   F    L   + +++ +  ++L   ++   + D + ++     + + D++ 
Sbjct: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGD-AFDIQRCYCNYTTDVVA 192

Query: 194 KCAFSKETNCQTNSTHDPYAKAIFELSKIIFHR--LYSLLYHSDIIFKLS---PQGYRFQ 248
             AF    +    +  DP+ K      +    R  L  LL    I+  L+   P   R  
Sbjct: 193 SVAFGTPVD-SWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNR-D 250

Query: 249 KLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-SGSSFSDIDVH 307
           +L+   N+    +I          ++     + + +DFL +VL A+   S     D D+ 
Sbjct: 251 ELNGFFNKLIRNVI---------ALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV 301

Query: 308 SEVST--------------------------------FLLAGHDTLAASISWILYCLALN 335
            +V +                                FL+AG++ +  ++S+  Y LA N
Sbjct: 302 RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN 361

Query: 336 PEHQERCREEVRGILGDGSSITWDQLGE-MSYTTMCIKETCRLIPAVPSISRDLSKPLTF 394
           P+ QE+   EV        +  +  L E + Y  M I ET R+ P     +R+ ++    
Sbjct: 362 PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV 421

Query: 395 PDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNC 454
             G  +PAG  + +++  LHH+P  W +P+ F+P RF+ E   Q  P+ YLPF AG R+C
Sbjct: 422 L-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480

Query: 455 IGQEFAMIELKVTIALIL--LHFRVTPDPTRPLTFPNHFILKPKNGMYLHL 503
           +G    ++E+K+T+  +L    F+  P+   PL   +   L PKNG+Y+ +
Sbjct: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  132 bits (332), Expect = 7e-31
 Identities = 126/531 (23%), Positives = 227/531 (42%), Gaps = 69/531 (12%)

Query: 22  LALGLLQAIKLY----LRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYP 77
           L++ LL  +K Y      R   L    P P+P    F+G+  F +    E   E+ + Y 
Sbjct: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSP----FIGNLTFFRQGFWESQMELRKLYG 76

Query: 78  RAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAA----LDGPKW 133
               +++G  + F  I +PD  K +L   +  S +  + +  L  K +A     L   +W
Sbjct: 77  PLCGYYLGR-RMFIVISEPDMIKQVL--VENFSNFTNRMASGLEFKSVADSVLFLRDKRW 133

Query: 134 FQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIM 193
            + R  L   F    L   + +++ +  ++L   ++   + D + ++     + + D++ 
Sbjct: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGD-AFDIQRCYCNYTTDVVA 192

Query: 194 KCAFSKETNCQTNSTHDPYAKAIFELSKIIFHR--LYSLLYHSDIIFKLS---PQGYRFQ 248
             AF    +    +  DP+ K      +    R  L  LL    I+  L+   P   R  
Sbjct: 193 SVAFGTPVD-SWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNR-D 250

Query: 249 KLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-SGSSFSDIDVH 307
           +L+   N+    +I          ++     + + +DFL +VL A+   S     D D+ 
Sbjct: 251 ELNGFFNKLIRNVI---------ALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV 301

Query: 308 SEVST--------------------------------FLLAGHDTLAASISWILYCLALN 335
            +V +                                FL+AG++ +  ++S+  Y LA N
Sbjct: 302 RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN 361

Query: 336 PEHQERCREEVRGILGDGSSITWDQLGE-MSYTTMCIKETCRLIPAVPSISRDLSKPLTF 394
           P+ QE+   EV        +  +  L E + Y  M I ET R+ P     +R+ ++    
Sbjct: 362 PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV 421

Query: 395 PDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNC 454
             G  +PAG  + +++  LHH+P  W +P+ F+P RF+ E   Q  P+ YLPF AG R+C
Sbjct: 422 L-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480

Query: 455 IGQEFAMIELKVTIALIL--LHFRVTPDPTRPLTFPNHFILKPKNGMYLHL 503
           +G    ++E+K+T+  +L    F+  P+   PL   +   L PKNG+Y+ +
Sbjct: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531


>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 509

 Score =  123 bits (308), Expect = 5e-28
 Identities = 106/425 (24%), Positives = 181/425 (42%), Gaps = 33/425 (7%)

Query: 54  FLGHQKFIQDDNMEKLEEIIEKYPRAFPF-WIGPFQAFFCIYDPDYAKTLLSRTDPK--- 109
           FLGH        +E LE   EKY   F F  +G  + F  +   D A  L +  +     
Sbjct: 76  FLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVG--KTFTYLLGSDAAALLFNSKNEDLNA 133

Query: 110 SQYLQKFSPPLLGKGLAA-LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWE 168
                + + P+ GKG+A  +  P + + +++L  G +    K ++ ++    K   + W 
Sbjct: 134 EDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWG 193

Query: 169 KICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLY 228
                +     V+E ++ + +     C   KE   Q N   +  A+   +L     H  +
Sbjct: 194 -----ESGEKNVFEALSELIILTASHCLHGKEIRSQLN---EKVAQLYADLDGGFSHAAW 245

Query: 229 SLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLD 288
            L     +     P   R  +  R +       IQ+R++S           + K  D L 
Sbjct: 246 LLPGWLPL-----PSFRRRDRAHREIKDIFYKAIQKRRQS-----------QEKIDDILQ 289

Query: 289 IVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRG 348
            +L A  + G   +D +V   +   LLAG  T + + +W+ + LA +   Q++C  E + 
Sbjct: 290 TLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT 349

Query: 349 ILGDG-SSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVV 407
           + G+    +T+DQL +++    CIKET RL P +  + R    P T   G T+P G  V 
Sbjct: 350 VCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVC 408

Query: 408 LSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVT 467
           +S          W     F+P R+ Q+N      +AY+PF AG   CIG+ FA +++K  
Sbjct: 409 VSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTI 468

Query: 468 IALIL 472
            + +L
Sbjct: 469 WSTML 473


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  119 bits (297), Expect = 9e-27
 Identities = 98/391 (25%), Positives = 181/391 (46%), Gaps = 18/391 (4%)

Query: 47  PAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRT 106
           P P    FLG   F          E  EKY   +  + G  Q    I DPD  KT+L + 
Sbjct: 39  PGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQ-QPMLVIMDPDMIKTVLVKE 97

Query: 107 DPKSQYLQKFSPPL--LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMML 164
                  Q    P+  L   L+  +  +W + R LL+P F     K  + +++    M++
Sbjct: 98  CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV 157

Query: 165 DKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIF 224
               +       S+ + +   + ++D+I    F    +   N+  DP+ K + +L K+ F
Sbjct: 158 RSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLD-SLNNPQDPFLKNMKKLLKLDF 215

Query: 225 HRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRK-- 282
              + LL    +   L+P    F+ L+  +  +   +    K S++   +     K+K  
Sbjct: 216 LDPFLLLI--SLFPFLTPV---FEALN--IGLFPKDVTHFLKNSIERMKESRLKDKQKHR 268

Query: 283 ---YQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
              +Q  +D   S + +S  + SD+++ ++    + A +DT + ++ +I+Y LA +P+ Q
Sbjct: 269 VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQ 328

Query: 340 ERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCT 399
           ++ +EE+  +L + + +T+D L +M Y  M + ET RL P V  ++R   K +   +G  
Sbjct: 329 QKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVF 387

Query: 400 LPAGITVVLSIWGLHHNPAVWKNPKVFDPLR 430
           +P G+ V++ I+ LHH+P  W  P+ F P R
Sbjct: 388 IPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  116 bits (290), Expect = 6e-26
 Identities = 96/371 (25%), Positives = 169/371 (45%), Gaps = 29/371 (7%)

Query: 116 FSPPLLGKGLAA-LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 174
           F   L G+GL +  +  +W + RR++   F  + L + +E      + +++  E     Q
Sbjct: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQ 175

Query: 175 DTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 234
            T V + + +   ++DI+ K AF  ET+    +           LS+ +   L  +    
Sbjct: 176 -TPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP--------LSQAVKLMLEGITASR 226

Query: 235 DIIFKLSP----QGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV 290
           + + K  P    Q    ++  R L Q     +Q R+++L+ G   +  P       L   
Sbjct: 227 NTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRG---EEVPADILTQILKAE 283

Query: 291 LSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGIL 350
             A+D+ G       +     TF +AGH+T A  +++ +  L+  PE   R + EV  ++
Sbjct: 284 EGAQDDEG-------LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI 336

Query: 351 GDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSI 410
           G    + ++ LG + Y +  +KE+ RL P      R L +  T  DG  +P    ++ S 
Sbjct: 337 GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFST 395

Query: 411 WGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIAL 470
           + +      +++P  F+P RF       R  + Y PFS G R+CIGQ+FA +E+KV +A 
Sbjct: 396 YVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAK 453

Query: 471 IL--LHFRVTP 479
           +L  L FR+ P
Sbjct: 454 LLQRLEFRLVP 464


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  115 bits (288), Expect = 9e-26
 Identities = 63/218 (28%), Positives = 108/218 (49%), Gaps = 7/218 (3%)

Query: 275 QDNTPKRKYQDFLDIVL-----SAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWIL 329
           Q++  +   QDF+D+ L       K+ S SSF +  +   +    +AG DT   S+ W L
Sbjct: 306 QESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCL 365

Query: 330 YCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLS 389
             ++LNP+ QE+  EE+  ++G   + +     +M YT   I E  RL   VP     ++
Sbjct: 366 LYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMT 425

Query: 390 KPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSA 449
              T   G T+P G  ++ ++W +H +PA+W+ P+ F P RF  +         ++PF  
Sbjct: 426 SENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGI 485

Query: 450 GSRNCIGQEFAMIELKVTIALIL--LHFRVTPDPTRPL 485
           G R C+G++ A +EL +    ++    F +  D  +PL
Sbjct: 486 GKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPL 523


>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 2 [Homo sapiens]
          Length = 404

 Score =  114 bits (284), Expect = 3e-25
 Identities = 89/360 (24%), Positives = 158/360 (43%), Gaps = 27/360 (7%)

Query: 115 KFSPPLLGKGLAA-LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICST 173
           + + P+ GKG+A  +  P + + +++L  G +    K ++ ++    K   + W      
Sbjct: 34  RLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWG----- 88

Query: 174 QDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYH 233
           +     V+E ++ + +     C   KE   Q N   +  A+   +L     H  + L   
Sbjct: 89  ESGEKNVFEALSELIILTASHCLHGKEIRSQLN---EKVAQLYADLDGGFSHAAWLLPGW 145

Query: 234 SDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSA 293
             +     P   R  +  R +       IQ+R++S           + K  D L  +L A
Sbjct: 146 LPL-----PSFRRRDRAHREIKDIFYKAIQKRRQS-----------QEKIDDILQTLLDA 189

Query: 294 KDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDG 353
             + G   +D +V   +   LLAG  T + + +W+ + LA +   Q++C  E + + G+ 
Sbjct: 190 TYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGEN 249

Query: 354 -SSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWG 412
              +T+DQL +++    CIKET RL P +  + R    P T   G T+P G  V +S   
Sbjct: 250 LPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGHQVCVSPTV 308

Query: 413 LHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALIL 472
                  W     F+P R+ Q+N      +AY+PF AG   CIG+ FA +++K   + +L
Sbjct: 309 NQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTML 368


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  105 bits (261), Expect = 1e-22
 Identities = 92/384 (23%), Positives = 171/384 (44%), Gaps = 34/384 (8%)

Query: 122 GKGLAALDGPKWFQHR-----RLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDT 176
           G GL  L+G  W + R     +L+ PG    +     EV+A      + + +++C  +  
Sbjct: 144 GYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLAD----FMGRIDELCDERGH 199

Query: 177 SVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKII--FHRLYSLLYHS 234
             ++Y  +N  S + I    + K       +  D     I  +  ++  F R+       
Sbjct: 200 VEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMM------ 253

Query: 235 DIIFKLSPQGYRFQKLSRVLNQYT---DTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVL 291
                ++P        ++V   +T   DTI     KS++A +  +   K   Q   D + 
Sbjct: 254 -----VTPVELHKSLNTKVWQDHTLAWDTIF----KSVKACI-DNRLEKYSQQPSADFLC 303

Query: 292 SAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILG 351
               ++    S  ++++ V+   LA  +T A S+ WILY L+ NP+ Q++  +E++ +L 
Sbjct: 304 DIYHQN--RLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLP 361

Query: 352 DGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIW 411
           +      + L  M Y   C+KE+ RL P+VP  +R L K     +   LP G  ++L+  
Sbjct: 362 ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGTVLMLNTQ 420

Query: 412 GLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALI 471
            L  +   +++   F P R+ QE  ++ +P+A+LPF  G R CIG+  A ++L + +  I
Sbjct: 421 VLGSSEDNFEDSSQFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWI 479

Query: 472 LLHFRVTPDPTRPLTFPNHFILKP 495
           +  + +      P+   +   L P
Sbjct: 480 VRKYDIQATDNEPVEMLHSGTLVP 503


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  103 bits (258), Expect = 3e-22
 Identities = 67/195 (34%), Positives = 98/195 (50%), Gaps = 5/195 (2%)

Query: 310 VSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSI--TWDQLGEMSYT 367
           V+  LLAG DT++ ++SW LY L+ +PE Q     E+   L  GSS   +   L ++   
Sbjct: 311 VTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLL 370

Query: 368 TMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFD 427
              +KE  RL P VP  SR   K +   D   +P    V L  +    +PA +  P  F 
Sbjct: 371 KAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRDPAQFPEPNSFR 429

Query: 428 PLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDP-TRPLT 486
           P R+  E     HP+A LPF  G R+C+G+  A +EL++ +A IL HF V P+P   P+ 
Sbjct: 430 PARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVR 488

Query: 487 FPNHFILKPKNGMYL 501
                +L P+  + L
Sbjct: 489 PKTRTVLVPERSINL 503


>gi|239757171 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  103 bits (256), Expect = 5e-22
 Identities = 52/159 (32%), Positives = 89/159 (55%), Gaps = 5/159 (3%)

Query: 139 LLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFS 198
           +L P FHFNILK Y+++   SV +M  KW  +    +  ++++EH+N M+LD + KC FS
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 199 KETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYT 258
            ++ CQ   +   Y  ++ ELS ++  R   +L H D ++ L+  G  F +  R+ + + 
Sbjct: 61  FDSQCQEKPSE--YIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118

Query: 259 DTIIQERKKSLQAGVKQD---NTPKRKYQDFLDIVLSAK 294
           D  IQE++ +L +    D      K K  DF+D++L +K
Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157


>gi|239751683 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  103 bits (256), Expect = 5e-22
 Identities = 52/159 (32%), Positives = 89/159 (55%), Gaps = 5/159 (3%)

Query: 139 LLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFS 198
           +L P FHFNILK Y+++   SV +M  KW  +    +  ++++EH+N M+LD + KC FS
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 199 KETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYT 258
            ++ CQ   +   Y  ++ ELS ++  R   +L H D ++ L+  G  F +  R+ + + 
Sbjct: 61  FDSQCQEKPSE--YIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118

Query: 259 DTIIQERKKSLQAGVKQD---NTPKRKYQDFLDIVLSAK 294
           D  IQE++ +L +    D      K K  DF+D++L +K
Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,773,461
Number of Sequences: 37866
Number of extensions: 938166
Number of successful extensions: 2750
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2522
Number of HSP's gapped (non-prelim): 109
length of query: 509
length of database: 18,247,518
effective HSP length: 107
effective length of query: 402
effective length of database: 14,195,856
effective search space: 5706734112
effective search space used: 5706734112
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.