BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|29789054 FCH domain only 1 isoform b [Homo sapiens] (889 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239049457 FCH domain only 1 isoform b [Homo sapiens] 1786 0.0 gi|29789054 FCH domain only 1 isoform b [Homo sapiens] 1786 0.0 gi|239049440 FCH domain only 1 isoform a [Homo sapiens] 1771 0.0 gi|239049540 FCH domain only 1 isoform c [Homo sapiens] 1682 0.0 gi|226371723 FCH domain only 2 isoform a [Homo sapiens] 736 0.0 gi|226371725 FCH domain only 2 isoform b [Homo sapiens] 684 0.0 gi|116235472 SH3-domain GRB2-like (endophilin) interacting prote... 312 8e-85 gi|20149528 proline-serine-threonine phosphatase interacting pro... 95 3e-19 gi|165905601 proline-serine-threonine phosphatase interacting pr... 90 8e-18 gi|195546919 growth arrest-specific 7 isoform d [Homo sapiens] 88 4e-17 gi|41406080 growth arrest-specific 7 isoform c [Homo sapiens] 88 4e-17 gi|41406078 growth arrest-specific 7 isoform b [Homo sapiens] 88 4e-17 gi|41406076 growth arrest-specific 7 isoform a [Homo sapiens] 88 4e-17 gi|19224660 protein kinase C and casein kinase substrate in neur... 57 6e-08 gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 55 2e-07 gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 55 3e-07 gi|116256464 hypothetical protein LOC343990 [Homo sapiens] 54 6e-07 gi|163965366 nascent polypeptide-associated complex alpha subuni... 54 6e-07 gi|157168329 formin 1 [Homo sapiens] 53 1e-06 gi|239752265 PREDICTED: hypothetical protein XP_002348186 [Homo ... 52 3e-06 gi|51702222 SPT2, Suppressor of Ty, domain containing 1 [Homo sa... 51 5e-06 gi|157743252 pecanex-like 3 [Homo sapiens] 50 7e-06 gi|18959210 WIRE protein [Homo sapiens] 50 7e-06 gi|187829452 autism susceptibility candidate 2 isoform 2 [Homo s... 50 9e-06 gi|17864090 autism susceptibility candidate 2 isoform 1 [Homo sa... 50 9e-06 gi|157074225 nuclear pore complex interacting protein-like 3 [Ho... 50 9e-06 gi|150170670 piccolo isoform 2 [Homo sapiens] 50 1e-05 gi|150378539 piccolo isoform 1 [Homo sapiens] 50 1e-05 gi|33356148 formin-like 1 [Homo sapiens] 49 2e-05 gi|223972704 hypothetical protein LOC284418 [Homo sapiens] 49 3e-05 >gi|239049457 FCH domain only 1 isoform b [Homo sapiens] Length = 889 Score = 1786 bits (4625), Expect = 0.0 Identities = 889/889 (100%), Positives = 889/889 (100%) Query: 1 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN Sbjct: 1 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 Query: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST Sbjct: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 Query: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE Sbjct: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180 Query: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI Sbjct: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240 Query: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE Sbjct: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300 Query: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH Sbjct: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360 Query: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS 420 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS Sbjct: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS 420 Query: 421 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP 480 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP Sbjct: 421 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP 480 Query: 481 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA 540 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA Sbjct: 481 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA 540 Query: 541 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER 600 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER Sbjct: 541 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER 600 Query: 601 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP 660 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP Sbjct: 601 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP 660 Query: 661 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA 720 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA Sbjct: 661 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA 720 Query: 721 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA 780 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA Sbjct: 721 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA 780 Query: 781 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS 840 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS Sbjct: 781 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS 840 Query: 841 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC Sbjct: 841 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889 >gi|29789054 FCH domain only 1 isoform b [Homo sapiens] Length = 889 Score = 1786 bits (4625), Expect = 0.0 Identities = 889/889 (100%), Positives = 889/889 (100%) Query: 1 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN Sbjct: 1 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 Query: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST Sbjct: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 Query: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE Sbjct: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180 Query: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI Sbjct: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240 Query: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE Sbjct: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300 Query: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH Sbjct: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360 Query: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS 420 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS Sbjct: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS 420 Query: 421 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP 480 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP Sbjct: 421 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP 480 Query: 481 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA 540 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA Sbjct: 481 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA 540 Query: 541 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER 600 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER Sbjct: 541 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER 600 Query: 601 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP 660 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP Sbjct: 601 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP 660 Query: 661 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA 720 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA Sbjct: 661 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA 720 Query: 721 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA 780 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA Sbjct: 721 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA 780 Query: 781 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS 840 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS Sbjct: 781 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS 840 Query: 841 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC Sbjct: 841 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889 >gi|239049440 FCH domain only 1 isoform a [Homo sapiens] Length = 891 Score = 1771 bits (4586), Expect = 0.0 Identities = 882/882 (100%), Positives = 882/882 (100%) Query: 1 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN Sbjct: 1 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 Query: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST Sbjct: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 Query: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE Sbjct: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180 Query: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI Sbjct: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240 Query: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE Sbjct: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300 Query: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH Sbjct: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360 Query: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS 420 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS Sbjct: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSS 420 Query: 421 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP 480 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP Sbjct: 421 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP 480 Query: 481 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA 540 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA Sbjct: 481 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALA 540 Query: 541 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER 600 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER Sbjct: 541 GGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALER 600 Query: 601 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP 660 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP Sbjct: 601 PSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFP 660 Query: 661 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA 720 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA Sbjct: 661 AGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEA 720 Query: 721 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA 780 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA Sbjct: 721 LQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATA 780 Query: 781 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS 840 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS Sbjct: 781 VPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLS 840 Query: 841 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFAT 882 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFAT Sbjct: 841 GPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFAT 882 >gi|239049540 FCH domain only 1 isoform c [Homo sapiens] Length = 839 Score = 1682 bits (4356), Expect = 0.0 Identities = 839/839 (100%), Positives = 839/839 (100%) Query: 51 MAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTH 110 MAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTH Sbjct: 1 MAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTH 60 Query: 111 KKCKEEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKK 170 KKCKEEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKK Sbjct: 61 KKCKEEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKK 120 Query: 171 AAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIG 230 AAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIG Sbjct: 121 AAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIG 180 Query: 231 QVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFR 290 QVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFR Sbjct: 181 QVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFR 240 Query: 291 LPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFD 350 LPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFD Sbjct: 241 LPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFD 300 Query: 351 DEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQ 410 DEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQ Sbjct: 301 DEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQ 360 Query: 411 RPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPE 470 RPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPE Sbjct: 361 RPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPE 420 Query: 471 NVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASS 530 NVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASS Sbjct: 421 NVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASS 480 Query: 531 PGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLG 590 PGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLG Sbjct: 481 PGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLG 540 Query: 591 SSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLAR 650 SSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLAR Sbjct: 541 SSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLAR 600 Query: 651 VTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDF 710 VTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDF Sbjct: 601 VTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDF 660 Query: 711 WLNMAALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSV 770 WLNMAALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSV Sbjct: 661 WLNMAALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSV 720 Query: 771 EYGYRPGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSG 830 EYGYRPGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSG Sbjct: 721 EYGYRPGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSG 780 Query: 831 RLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889 RLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC Sbjct: 781 RLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 839 >gi|226371723 FCH domain only 2 isoform a [Homo sapiens] Length = 810 Score = 736 bits (1901), Expect = 0.0 Identities = 404/897 (45%), Positives = 568/897 (63%), Gaps = 97/897 (10%) Query: 1 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 M+YF E+FWGEKN GF+VLYH++K G ISTKELADF+RERATIEE YS++M KL+K ASN Sbjct: 3 MAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASN 62 Query: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 + +GTFAP+W+VF+ S++KLA CHL+L RKLQ+LIK+V +YGEEQ+K+HKK KEEV T Sbjct: 63 YSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGT 122 Query: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180 L+AVQ + ++Q L KS+ENY +C++QERL++E +Q+E++KA K+KKA ++ + VE Sbjct: 123 LEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVE 182 Query: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240 KY A+ADFEQKM ++A +FQ +EETHL H+K ++GS ++++++ H+QIGQVHEEF N+ Sbjct: 183 KYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNM 242 Query: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300 N +VE L++KFAESKGTG+E+PG ++FE A+ E +K R K F LPG+ ++E++ Sbjct: 243 ANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKP-RKRKTFALPGIIKKEKD 301 Query: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360 E +V+ + DS P+VDEEG++++P+ QN T E +SSSDSD +DEEP+K+ + Sbjct: 302 AE---SVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIE 358 Query: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGG----TMKRHSSRDAAGKPQRPRSAP 416 IKP + A+ +L+ + G++ L P M R+ S + K +P + P Sbjct: 359 IKPMHPN-NSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTK-SKPSAPP 416 Query: 417 RTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSG 476 ++ L + LFGP L+S SSS TSS S Sbjct: 417 NEKGTSDLLAWDP-----LFGPSLDS---------SSSSSLTSSSS-------------- 448 Query: 477 LDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGL 536 RP TP S + I PP P S L S Sbjct: 449 -----------------ARPTTPLSVGT----------IVPPPRPASRPKLTSG------ 475 Query: 537 EALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAAST 596 L+G + +P P P + PP + PL R+ S S + SSA+ + Sbjct: 476 -KLSGINEIPRPFSPPVTSNTSPPP--------AAPLARAE-------SSSSISSSASLS 519 Query: 597 ALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPS-CLARVTGEL 655 A P+ GVSRGPSPV LG+QD LP+A A TE V+AYF+G P+ C+ ++TG++ Sbjct: 520 AANTPTV------GVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDM 573 Query: 656 TMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMA 715 TM+FP+GI++VF+ P P VL FR+ + + +E PNA L+FSDPSQ D TKDFW+NM Sbjct: 574 TMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQ 633 Query: 716 ALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYR 775 A+T L++ +EQNP ASYYNV +L+YQ S G QS PL L+ +W+C A+ T + V+Y Y Sbjct: 634 AVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYN 693 Query: 776 PGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEA---GGSGRL 832 P A P+ L+N+Q+++PV VTN++ P A WN E+ + W+L +SE GGSG L Sbjct: 694 PEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSGSL 753 Query: 833 SASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889 A ++ GPS P+ +A QF SEG+TLSGVD ELVG+GYR+SL+K+RFATG YL C Sbjct: 754 RAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFATGRYLADC 810 >gi|226371725 FCH domain only 2 isoform b [Homo sapiens] Length = 777 Score = 684 bits (1765), Expect = 0.0 Identities = 389/897 (43%), Positives = 541/897 (60%), Gaps = 130/897 (14%) Query: 1 MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 M+YF E+FWGEKN GF+VLYH++K G ISTKELADF+RERATIEE YS++M KL+K ASN Sbjct: 3 MAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASN 62 Query: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 + +GTFAP+W+VF+ S++KLA CHL+L RKLQ+LIK+V +YGEEQ+K+HKK KEEV T Sbjct: 63 YSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGT 122 Query: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180 L+AVQ + ++Q L KS+ENY +C++QERL++E +Q+E++KA K+KKA ++ + VE Sbjct: 123 LEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVE 182 Query: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240 KY A+ADFEQKM ++A QVHEEF N+ Sbjct: 183 KYALAKADFEQKMTETA---------------------------------QVHEEFINNM 209 Query: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300 N +VE L++KFAESKGTG+E+PG ++FE A+ E +K R K F LPG+ ++E++ Sbjct: 210 ANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKP-RKRKTFALPGIIKKEKD 268 Query: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360 E +V+ + DS P+VDEEG++++P+ QN T E +SSSDSD +DEEP+K+ + Sbjct: 269 AE---SVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIE 325 Query: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGG----TMKRHSSRDAAGKPQRPRSAP 416 IKP + A+ +L+ + G++ L P M R+ S + K +P + P Sbjct: 326 IKPMHPNN-SHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTK-SKPSAPP 383 Query: 417 RTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSG 476 ++ L + LFGP L+S SSS TSS S Sbjct: 384 NEKGTSDLLAWDP-----LFGPSLDS---------SSSSSLTSSSSA------------- 416 Query: 477 LDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGL 536 RP TP S + I PP P S L S Sbjct: 417 ------------------RPTTPLSVGT----------IVPPPRPASRPKLTSGK----- 443 Query: 537 EALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAAST 596 L+G + +P P P + PP + PL R+ S S + SSA+ + Sbjct: 444 --LSGINEIPRPFSPPVTSNTSPPP--------AAPLARAE-------SSSSISSSASLS 486 Query: 597 ALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPS-CLARVTGEL 655 A P+ GVSRGPSPV LG+QD LP+A A TE V+AYF+G P+ C+ ++TG++ Sbjct: 487 AANTPTV------GVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDM 540 Query: 656 TMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMA 715 TM+FP+GI++VF+ P P VL FR+ + + +E PNA L+FSDPSQ D TKDFW+NM Sbjct: 541 TMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQ 600 Query: 716 ALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYR 775 A+T L++ +EQNP ASYYNV +L+YQ S G QS PL L+ +W+C A+ T + V+Y Y Sbjct: 601 AVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYN 660 Query: 776 PGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEA---GGSGRL 832 P A P+ L+N+Q+++PV VTN++ P A WN E+ + W+L +SE GGSG L Sbjct: 661 PEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSGSL 720 Query: 833 SASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889 A ++ GPS P+ +A QF SEG+TLSGVD ELVG+GYR+SL+K+RFATG YL C Sbjct: 721 RAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFATGRYLADC 777 >gi|116235472 SH3-domain GRB2-like (endophilin) interacting protein 1 [Homo sapiens] Length = 828 Score = 312 bits (800), Expect = 8e-85 Identities = 201/548 (36%), Positives = 288/548 (52%), Gaps = 47/548 (8%) Query: 349 FDDEEPRKFYVHIKPAP-ARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAG 407 F D P + P +P +P+ A + A + PPGP G G Sbjct: 315 FSDTSPEHVTPELTPREKVVSPPATPDNPAD---SPAPGPLGPPGPTGP---------PG 362 Query: 408 KPQRPRS--APRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFS 465 P PR+ +P ++ +E+ K+ + LE+ +DF LG ++P P Sbjct: 363 PPGPPRNVLSPLNLEEVQKKVAEQTFIKDDY---LETISSPKDF----GLGQRATPPP-- 413 Query: 466 SSSPENVEDSGLDSPSHAA-PGPSPDSWVPRPGTPQSP-PSCRAPPPEARGIRAPPLPDS 523 P + + SP + PGP S P P +P CR+ P PP P Sbjct: 414 --PPPPTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPP------PPPPRP 465 Query: 524 PQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRS 583 P PG G+ GD+ P P + PP +R S S LS + Sbjct: 466 PSRPKLPPGKPGV-----GDVS-RPFSPPIHSS-SPPPIAPLARAESTSSISSTNSLSAA 518 Query: 584 LSPSPLGSSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGH 643 +P+ + +R F T G SRGPSP+ +G+QD LP+A AFTE V+AYF+G Sbjct: 519 TTPTVENEQPSLVWFDRGKFYL-TFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGA 577 Query: 644 SPS-CLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQ 702 PS C+ ++TGE+ ++FPAGI R F+ P P L+FR+++ + +EH PN LL D +Q Sbjct: 578 DPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQ 637 Query: 703 SDPETKDFWLNMAALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCG 762 +D TK+FW+NM L L++ +EQ P A+YYNV +L+YQ S G QS PL L+ +W+C Sbjct: 638 NDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCE 697 Query: 763 ATLTQVSVEYGYRPGATAVPTPLTNVQILLPVGEPVTNVR-LQPAATWNLEEKRLTWRLP 821 + T + ++Y Y A L NVQ L+P+ VT ++ + P A WN E++R+ W++P Sbjct: 698 PSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIP 757 Query: 822 DV---SEAGGSGRLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKR 878 D+ SE GG G L A ++ GPS PSP+ QFTSEG+TLSG D+ELVG+GYR SL+K+ Sbjct: 758 DISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKK 817 Query: 879 RFATGMYL 886 RFA G YL Sbjct: 818 RFAAGKYL 825 Score = 84.3 bits (207), Expect = 4e-16 Identities = 81/294 (27%), Positives = 127/294 (43%), Gaps = 40/294 (13%) Query: 318 PEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVHIKPAPARAPACSPEAAA 377 PE+DEEG+++RP+ ST +SSS+S+ ++E +KF + IKP ++ A Sbjct: 79 PELDEEGYSIRPE-EPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSK-DILKNAATV 136 Query: 378 AQLRATAGSLILPPGP--------GGTMKRHSSRDAAGKPQRPRSAPRTSSCAERLQSEE 429 +L+A+ G++ L P P G +KR+ S + +P+R S P +++ + Sbjct: 137 DELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRR--STPTPELISKKPPDDT 194 Query: 430 QVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSP 489 LFGPPLESAFD + + P + S P N ++SP P P Sbjct: 195 TALAPLFGPPLESAFDEQ-----KTEVLLDQPEIWGSGQPIN---PSMESPKLTRPFP-- 244 Query: 490 DSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPD---SPQPLASSPGPWGLEALAGGDLMP 546 + P P P++ P+ PP + P D + + P L+++ G L P Sbjct: 245 -TGTPPPLPPKNVPA--TPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFGPVLSP 301 Query: 547 APADPTAREGL----------AAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLG 590 A E P R + VS P T N + S +P PLG Sbjct: 302 KSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNP--ADSPAPGPLG 353 >gi|20149528 proline-serine-threonine phosphatase interacting protein 1 [Homo sapiens] Length = 416 Score = 94.7 bits (234), Expect = 3e-19 Identities = 63/285 (22%), Positives = 140/285 (49%), Gaps = 21/285 (7%) Query: 4 FGEHFWGEK---NHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60 F + FW + G+EVL + G K++ + +R+RA EE Y K + ++++ A Sbjct: 7 FKDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGG 66 Query: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120 T + + ++ + + + H++L L++ ++ + + E Q + KK + + Sbjct: 67 QTEINSLRASFDSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYE----AV 122 Query: 121 LDAVQVLS-GVSQLLPKSRENYLNRCMD----QERLRRESTS--QKEMDKAETKTKKAAE 173 +D VQ + + +S++ Y +C D ++ R S + QK+++K++ K ++ + Sbjct: 123 MDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKD 182 Query: 174 SL-------RRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTH 226 S R+S+ + RA++EQ+ + FQ E L ++ L +++ + Sbjct: 183 SATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQC 242 Query: 227 VQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAY 271 V+ +++EE + +E S++ + F ++K TG E P P+ ++ Y Sbjct: 243 VKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQNY 287 >gi|165905601 proline-serine-threonine phosphatase interacting protein 2 [Homo sapiens] Length = 334 Score = 90.1 bits (222), Expect = 8e-18 Identities = 70/324 (21%), Positives = 146/324 (45%), Gaps = 25/324 (7%) Query: 2 SYFGEHFWGE---KNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLA 58 S F +FW G++ + + G + KE DF++ERA IEE Y K + LS+ Sbjct: 4 SLFKGNFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRKK 63 Query: 59 SNG-TPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEV 117 G + + T EVF+ D +A CH++L + L++ + + + E+Q K +K E + Sbjct: 64 PCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQSLREEARKMEEFREKQ-KLQRKKTELI 122 Query: 118 VSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLRR------ESTSQKEMDKAETKTKKA 171 + + + L + +++NY +C D++ + + K+ +K K + Sbjct: 123 MDAIHKQKSLQFKKTM--DAKKNYEQKCRDKDEAEQAVSRSANLVNPKQQEKLFVKLATS 180 Query: 172 AESLRRSVEKY-------NSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVED 224 ++ S + Y + R +++ + + + F+A E + + L + + + Sbjct: 181 KTAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEAQECERINFFRNALWLHVNQLSQ 240 Query: 225 THVQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLR 284 V +++E+ ++++E S++ + F + TG+ P P+ +E + + K Sbjct: 241 QCVTSDEMYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENF-----YSSQKNAV 295 Query: 285 GAKAFRLPGLSRREREPEPPAAVD 308 A P L+RR P P ++ D Sbjct: 296 PAGKATGPNLARRGPLPIPKSSPD 319 >gi|195546919 growth arrest-specific 7 isoform d [Homo sapiens] Length = 412 Score = 87.8 bits (216), Expect = 4e-17 Identities = 69/266 (25%), Positives = 125/266 (46%), Gaps = 27/266 (10%) Query: 6 EHFWGEKNH--------GFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKL 57 ++FW +K GFE+L +G KE+++FIRER IEE Y+K +AKLS+ Sbjct: 138 DYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQN 197 Query: 58 ASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKL-QDLIKDVLRYGEEQLKTHKKCKEE 116 + G+ W + S A HL+ + KL ++ K ++ + E K KKC Sbjct: 198 SLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHH 257 Query: 117 VVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQE------RLRRESTSQKEMDKAETKTKK 170 + D + L+ + K+R+ R D E ++ + +++++ KA K+ + Sbjct: 258 IA---DLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQ 314 Query: 171 AAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIG 230 A + L R V+ YN A++ + ++M+ + L + +E + ++ L Y +T Sbjct: 315 AGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHET----- 369 Query: 231 QVHEEFKQNIENVSVEMLLRKFAESK 256 + F Q+ V+ LLRK +K Sbjct: 370 ---DMFNQSTVE-PVDQLLRKVDPAK 391 >gi|41406080 growth arrest-specific 7 isoform c [Homo sapiens] Length = 476 Score = 87.8 bits (216), Expect = 4e-17 Identities = 69/266 (25%), Positives = 125/266 (46%), Gaps = 27/266 (10%) Query: 6 EHFWGEKNH--------GFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKL 57 ++FW +K GFE+L +G KE+++FIRER IEE Y+K +AKLS+ Sbjct: 202 DYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQN 261 Query: 58 ASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKL-QDLIKDVLRYGEEQLKTHKKCKEE 116 + G+ W + S A HL+ + KL ++ K ++ + E K KKC Sbjct: 262 SLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHH 321 Query: 117 VVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQE------RLRRESTSQKEMDKAETKTKK 170 + D + L+ + K+R+ R D E ++ + +++++ KA K+ + Sbjct: 322 IA---DLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQ 378 Query: 171 AAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIG 230 A + L R V+ YN A++ + ++M+ + L + +E + ++ L Y +T Sbjct: 379 AGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHET----- 433 Query: 231 QVHEEFKQNIENVSVEMLLRKFAESK 256 + F Q+ V+ LLRK +K Sbjct: 434 ---DMFNQSTVE-PVDQLLRKVDPAK 455 >gi|41406078 growth arrest-specific 7 isoform b [Homo sapiens] Length = 416 Score = 87.8 bits (216), Expect = 4e-17 Identities = 69/266 (25%), Positives = 125/266 (46%), Gaps = 27/266 (10%) Query: 6 EHFWGEKNH--------GFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKL 57 ++FW +K GFE+L +G KE+++FIRER IEE Y+K +AKLS+ Sbjct: 142 DYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQN 201 Query: 58 ASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKL-QDLIKDVLRYGEEQLKTHKKCKEE 116 + G+ W + S A HL+ + KL ++ K ++ + E K KKC Sbjct: 202 SLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHH 261 Query: 117 VVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQE------RLRRESTSQKEMDKAETKTKK 170 + D + L+ + K+R+ R D E ++ + +++++ KA K+ + Sbjct: 262 IA---DLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQ 318 Query: 171 AAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIG 230 A + L R V+ YN A++ + ++M+ + L + +E + ++ L Y +T Sbjct: 319 AGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHET----- 373 Query: 231 QVHEEFKQNIENVSVEMLLRKFAESK 256 + F Q+ V+ LLRK +K Sbjct: 374 ---DMFNQSTVE-PVDQLLRKVDPAK 395 >gi|41406076 growth arrest-specific 7 isoform a [Homo sapiens] Length = 336 Score = 87.8 bits (216), Expect = 4e-17 Identities = 69/266 (25%), Positives = 125/266 (46%), Gaps = 27/266 (10%) Query: 6 EHFWGEKNH--------GFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKL 57 ++FW +K GFE+L +G KE+++FIRER IEE Y+K +AKLS+ Sbjct: 62 DYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQN 121 Query: 58 ASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKL-QDLIKDVLRYGEEQLKTHKKCKEE 116 + G+ W + S A HL+ + KL ++ K ++ + E K KKC Sbjct: 122 SLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHH 181 Query: 117 VVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQE------RLRRESTSQKEMDKAETKTKK 170 + D + L+ + K+R+ R D E ++ + +++++ KA K+ + Sbjct: 182 IA---DLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQ 238 Query: 171 AAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIG 230 A + L R V+ YN A++ + ++M+ + L + +E + ++ L Y +T Sbjct: 239 AGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHET----- 293 Query: 231 QVHEEFKQNIENVSVEMLLRKFAESK 256 + F Q+ V+ LLRK +K Sbjct: 294 ---DMFNQSTVE-PVDQLLRKVDPAK 315 >gi|19224660 protein kinase C and casein kinase substrate in neurons 3 [Homo sapiens] Length = 424 Score = 57.4 bits (137), Expect = 6e-08 Identities = 80/382 (20%), Positives = 132/382 (34%), Gaps = 63/382 (16%) Query: 5 GEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSK----LASN 60 G FW N+ V V+ G +L +ERA IE+ Y++ +A ++ Sbjct: 13 GGSFWEAGNYRRTV--QRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEK 70 Query: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLR------------------- 101 G GT W F ++++L+ HLE+ KLQ + +R Sbjct: 71 GPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESR 130 Query: 102 -----YGEEQLKTHKKCKEEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLRREST 156 + + Q K+ KE S + + + QE+LR+ Sbjct: 131 AAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQE 190 Query: 157 SQKEMDKAETKTKKAAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMK-ALL 215 + K KTK E + +Y + ++ ++ QA E L K LL Sbjct: 191 RVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETC---QAAERQRLLFFKDMLL 247 Query: 216 GSYAHSVEDTHVQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAA 275 + H + + ++H + Q IE S E LR + + G G P FE +S Sbjct: 248 TLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWP-QFEEWSLDT 306 Query: 276 LQEAMKRLRGAKAFRLPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNS 335 + ++ +G R P+ + GT P G Sbjct: 307 QRTISRKEKGG------------RSPDEVTLTSIVPTRDGTAPPPQSPG----------- 343 Query: 336 TAEPSRFSSSDSDFDDEE-PRK 356 S + D ++ DEE PRK Sbjct: 344 ----SPGTGQDEEWSDEESPRK 361 >gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 1124 Score = 55.5 bits (132), Expect = 2e-07 Identities = 141/575 (24%), Positives = 204/575 (35%), Gaps = 77/575 (13%) Query: 303 PPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVHIK 362 PP V P S T P + + Q +T+ S + F PR+ + Sbjct: 387 PPIQV----PHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLT 442 Query: 363 PAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCA 422 +P+R + P++ Q L LP P + P SS A Sbjct: 443 -SPSRPASTPPDSPPLQ-----APLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLA 496 Query: 423 ERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVED--SGLDSP 480 S + +L PPLE+ SSL S +P +S + +E+ S P Sbjct: 497 SH--SPQAPLSSLIMPPLET---------QSSLAPPSLQTPPASLTTPPLENLPSLAPPP 545 Query: 481 SHAAPGPSPDSWVPRPGTP-----QSPPS-CRAPPPEARGIRAPPLPDSPQPLASSPGPW 534 A P + P P Q+PPS PPPE A P P +P LAS P Sbjct: 546 LQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP--- 602 Query: 535 GLEALAGGDLMP-APADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSA 593 L+ L L P A P A LA PP + + P ++ LS +PSP +A Sbjct: 603 -LQGLPSPPLSPLATPPPQAPPXLALPPLQ------APPSPPASPPLSPLATPSPQAPNA 655 Query: 594 ASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTG 653 + L + F V SP S P AT ++ +P LA Sbjct: 656 LAVHLLQAPFSPPPSPPVQAPFSPP--ASPPVSPSATPPSQ---------APPSLAAPPL 704 Query: 654 ELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLN 713 ++ + PA S TPPP + P + + PS + P Sbjct: 705 QVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPM--SPSATPPP------R 756 Query: 714 MAALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQC-GATLTQVSVEY 772 + L A Q +P AS L ++P PQ+ P + Q + + Sbjct: 757 VPPLLAAPPLQVPPSPPAS-----LPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQA 811 Query: 773 GYRPGATAVPTPLTNVQILLP--VGEPVTNVRLQPAATWNLE-EKRLTWRLPDVSEAGGS 829 + P A+ +PL P + P+ V P A+ L+ +R PD S +G Sbjct: 812 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG-- 869 Query: 830 GRLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDL 864 RL+ + P GP P S +TLSG DL Sbjct: 870 PRLTLALAP--GPPPPPS-----RSPSSTLSGPDL 897 Score = 52.0 bits (123), Expect = 2e-06 Identities = 88/353 (24%), Positives = 124/353 (35%), Gaps = 55/353 (15%) Query: 256 KGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRREREPEPPAAVDFLEPDSG 315 + +G +PGPL + +A +E + R + +A + LS R SG Sbjct: 119 RASGTTRPGPLGQKGLRISA-EETVARGKATEAPKRSALSAGARRDT-----------SG 166 Query: 316 TCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYV----HIKPAPARAPAC 371 P R P S+ E PRK H P+ A Sbjct: 167 PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 226 Query: 372 SPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCAERLQSEEQV 431 P A R + SL P + R S A G P+ P + + QV Sbjct: 227 RPSAGGGLQRPASRSLSSSATPLSSPAR-SGPSARGTPRAPAHPSQPKPKGLQALRPPQV 285 Query: 432 SKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPDS 491 + PP + A + +LG SS SP ++ SP S + A P P PD+ Sbjct: 286 T-----PPRKDA--------APALGPLSS-SPLATPSP---------SGTKARPVPPPDN 322 Query: 492 WV-PRPGT-PQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPA 549 P P T P SPP P APP P +P L + P P A P+ Sbjct: 323 AATPLPATLPPSPPLATPLP------LAPPSPSAPPSLQTLPSP---PATPPSQAPPSMT 373 Query: 550 DPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALERPS 602 P + APP + P + ++ L SP L S A+T+L P+ Sbjct: 374 TPP----MQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPT 422 Score = 48.5 bits (114), Expect = 3e-05 Identities = 74/294 (25%), Positives = 100/294 (34%), Gaps = 44/294 (14%) Query: 352 EEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKP-Q 410 + P VH+ AP P P A A+ P P T + A P Q Sbjct: 651 QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP-----PVSPSATPPSQAPPSLAAPPLQ 705 Query: 411 RPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPE 470 P S P + + Q L PPL+ +SP S++P Sbjct: 706 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPP-----------ASPPMSPSATPP 754 Query: 471 NVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASS 530 L +P P PSP + +P + PP +APP + PPL P P AS Sbjct: 755 PRVPPLLAAPPLQVP-PSPPASLPMSPLAKPPP--QAPP----ALATPPLQALPSPPASF 807 Query: 531 PGPWGLEALAGGDLMP-APADPTAREGLAAP----------------PRRLRSRKVSCPL 573 PG A + P A P A LAAP PRR + + Sbjct: 808 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSV 867 Query: 574 TRSNGDLSRSLSPSPLGSSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALP 627 + L+ + P P S + S+ L P GH S +P L D+ P Sbjct: 868 SGPRLTLALAPGPPPPPSRSPSSTLSGPDL---AGHSSSATSTPEELRGYDSGP 918 Score = 34.7 bits (78), Expect = 0.40 Identities = 48/189 (25%), Positives = 65/189 (34%), Gaps = 46/189 (24%) Query: 364 APARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCAE 423 AP R P P+ + + R T L L PGP P P +P Sbjct: 854 APRRPPTPGPDTSVSGPRLT---LALAPGP---------------PPPPSRSP------- 888 Query: 424 RLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHA 483 S L GP L T G+ S P +++SP + P+ Sbjct: 889 --------SSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAW 940 Query: 484 APGPSPD-SWVPRPGTPQSPPSCRAPPPEARGI----------RAPPLPDSPQPLASSPG 532 + GP+P ++ PG P P P A G+ A P P + P SPG Sbjct: 941 SRGPAPPLAFRGAPGAPLPWPPATG-PGSADGLCTIYETEGPESATPAPGALDP-GPSPG 998 Query: 533 PWGLEALAG 541 G +A AG Sbjct: 999 TSGGKAAAG 1007 Score = 34.3 bits (77), Expect = 0.53 Identities = 57/245 (23%), Positives = 80/245 (32%), Gaps = 61/245 (24%) Query: 474 DSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPP----------------------E 511 D+ D A +P + P TP+ P S R PPP Sbjct: 2 DNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAER 61 Query: 512 ARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSC 571 A GI +P+S A GP + PA P + G APP Sbjct: 62 AGGIGGATIPES----APRAGP--TRSAGTSSRNPASRPPASGRGERAPP---------- 105 Query: 572 PLTRSNGDLSRSLSPSPLGSSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATA 631 +++ SP P+ S ++ RP L Q G +S V G P +A Sbjct: 106 ---------AKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS-AEETVARGKATEAPKRSA 155 Query: 632 FTEYVHAYFRGHSPSC-------LARVTG-ELTMTFPAGIVRVFSGTPPPPVLSFRLVHT 683 + G +P +R G E+ + PA S P PP R + Sbjct: 156 LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP-----SARPRPPTEGPRKSVS 210 Query: 684 TAIEH 688 +A EH Sbjct: 211 SASEH 215 >gi|158854042 hypothetical protein LOC222183 [Homo sapiens] Length = 653 Score = 55.1 bits (131), Expect = 3e-07 Identities = 71/238 (29%), Positives = 93/238 (39%), Gaps = 32/238 (13%) Query: 398 KRHSSRDAAGKPQ---RPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFD--------- 445 +RH SR + K + + + P T S R S S + P L S + Sbjct: 222 RRHRSRSSKCKRKEKNKEKKRPHTESPGRR--SHRHSSGSSHSPSLSSHYSDSRSPSRLS 279 Query: 446 --HEDF---TGSSSLGFTSSPSPFSSS---SPENVEDSGLDSPSHAAPGPSPDSWVPRPG 497 H D TGS + SPSP S SP+ SG S +H S S +P Sbjct: 280 PKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPS 339 Query: 498 TP----QSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEA-LAGGDLMPAPADPT 552 +P + + AP P ARG +P SP+ SS G G A AG Sbjct: 340 SPSPRVRDKAAAAAPTPPARGKESP----SPRSAPSSQGRGGRAAGGAGRRRRRRRRRRR 395 Query: 553 AREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALERPSFLSQTGHG 610 +R +AP RR R R P S+ LSR+ S S GS + P S+ GHG Sbjct: 396 SRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRGAPG-PGPEPGSERGHG 452 Score = 33.1 bits (74), Expect = 1.2 Identities = 63/261 (24%), Positives = 84/261 (32%), Gaps = 35/261 (13%) Query: 362 KPAPARAPACSPEAAAAQLRATAGSLILPPGPG---GTMKRHSSRDAAGKPQRPRSAPRT 418 +P PA S + A+ + +GS PGPG G+ + H K + PR+ P + Sbjct: 410 RPRPAPPRGSSRSLSRARSSSDSGSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPAS 469 Query: 419 SSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLD 478 +S P A S + P P S SS + S Sbjct: 470 TS------------------PSPGAHGRRGGPEGKSSSRSPGPHPRSWSSSRSPSKSRSR 511 Query: 479 SPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLAS--SPGPWGL 536 S PS +P + RA EA RA S P+ P + Sbjct: 512 SAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSRSYSPIRKRRRDSPSFM 571 Query: 537 EALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAAST 596 E P T+ P R S L+ S S SPSP G S S Sbjct: 572 E----------PRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRSHSRSPSP-GHSHGSY 620 Query: 597 ALERPSFLSQTGHGVSRGPSP 617 + S+T SR PSP Sbjct: 621 SSRSHGTRSRT-RSPSRTPSP 640 >gi|116256464 hypothetical protein LOC343990 [Homo sapiens] Length = 962 Score = 53.9 bits (128), Expect = 6e-07 Identities = 94/377 (24%), Positives = 131/377 (34%), Gaps = 96/377 (25%) Query: 297 REREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDF---DDEE 353 +E EP PP D + G PE + E T + + + EP R + S Sbjct: 437 KEAEPTPPVLPDEEKGPPGPAPEPEREAET---EPERGAGTEPERIGTEPSTAPAPSPPA 493 Query: 354 PRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDA-AGKPQRP 412 P+ H A + PA SP AAA+ S + PGPG S DA A P+RP Sbjct: 494 PKSCLKHRPAAASEGPAASPPLAAAE------SPPVEPGPG-------SLDAEAAAPERP 540 Query: 413 RS--APRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSS-----------LGFTS 459 ++ A + AER E + + G L A + F+ SS L S Sbjct: 541 KAERAEAPPAGAERAAPERKAERG--GAELRGA---KKFSVSSCRARPRPGVSRPLERAS 595 Query: 460 SPSPFSSSSPENVEDSGLDS------PSHAAPGP-----------------------SPD 490 P + S P ++ LD P HA PGP SP Sbjct: 596 GRLPLARSGPVWRSEAALDDLQGLPEPQHAKPGPRKLAERGPQDSGDRAASPAGPRKSPQ 655 Query: 491 SWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPAD 550 PGT + P+ + P AP +P P+ L Sbjct: 656 EAAAAPGTREPCPAAQEP--------APSEDRNPFPV---------------KLRSTSLS 692 Query: 551 PTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALERPSFLSQTGHG 610 R+G + + ++ L RS L + PLG++ A P S G G Sbjct: 693 LKYRDGASQEVKGVKRYSAEVRLERSLTVLPKE-EKCPLGTAPALRGTRAP---SDQGKG 748 Query: 611 VSRGPSPVVLGSQDALP 627 +R P P L S+ LP Sbjct: 749 KARPPEP--LSSKPPLP 763 Score = 47.0 bits (110), Expect = 8e-05 Identities = 57/223 (25%), Positives = 80/223 (35%), Gaps = 25/223 (11%) Query: 365 PARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCAER 424 PA PE+A LR S P GP +D P P AP T E Sbjct: 336 PATPELAEPESAPT-LRVEPPSP--PEGPPNPGPDGGKQDGEAPPAGP-CAPATDKAEEV 391 Query: 425 LQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPE-NVEDSGLDSP--- 480 + + E V+ P +A D T + +S +P + PE +V +P Sbjct: 392 VCAPEDVAS-----PFPTAIPEGDTTPPETDPAATSEAPSARDGPERSVPKEAEPTPPVL 446 Query: 481 ---SHAAPGPSPD-----SWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDS---PQPLAS 529 PGP+P+ P G P P A +PP P S +P A+ Sbjct: 447 PDEEKGPPGPAPEPEREAETEPERGAGTEPERIGTEPSTAPA-PSPPAPKSCLKHRPAAA 505 Query: 530 SPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCP 572 S GP LA + P P + + AA P R ++ + P Sbjct: 506 SEGPAASPPLAAAESPPVEPGPGSLDAEAAAPERPKAERAEAP 548 Score = 32.7 bits (73), Expect = 1.5 Identities = 37/136 (27%), Positives = 52/136 (38%), Gaps = 19/136 (13%) Query: 465 SSSSPENVEDSGLDSPSHAAPGPSPDSW--VPRPGTPQSPPSCRAPPPEARGIRAPPLPD 522 SS+ +VE+ G+ PG P S P P+S P+ R PP P PD Sbjct: 315 SSALTASVEEGGV-------PGEDPSSRPATPELAEPESAPTLRVEPPSPPEGPPNPGPD 367 Query: 523 SPQPLASSP--GPWGLEALAGGDLMPAPAD-----PTA-REGLAAPPRRLRSRKVSCPLT 574 + +P GP +++ AP D PTA EG PP + P Sbjct: 368 GGKQDGEAPPAGPCAPATDKAEEVVCAPEDVASPFPTAIPEGDTTPPETDPAATSEAPSA 427 Query: 575 RSNGDLS--RSLSPSP 588 R + S + P+P Sbjct: 428 RDGPERSVPKEAEPTP 443 Score = 30.8 bits (68), Expect = 5.8 Identities = 57/260 (21%), Positives = 81/260 (31%), Gaps = 35/260 (13%) Query: 363 PAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKR--HSSRDAAGKPQRPRSAPRTSS 420 P P EAA L+ PGP +R S D A P PR +P+ ++ Sbjct: 599 PLARSGPVWRSEAALDDLQGLPEPQHAKPGPRKLAERGPQDSGDRAASPAGPRKSPQEAA 658 Query: 421 --------CAERLQSEEQVSKNLFGPPLES---AFDHEDFTGSSSLGFTSSPSPFSSSSP 469 C + +N F L S + + D G + Sbjct: 659 AAPGTREPCPAAQEPAPSEDRNPFPVKLRSTSLSLKYRDGASQEVKGVKRYSAEVRLERS 718 Query: 470 ENVEDSGLDSPSHAAPG----PSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQ 525 V P AP +P P P S + P P +++ LP P Sbjct: 719 LTVLPKEEKCPLGTAPALRGTRAPSDQGKGKARPPEPLSSKPPLPRKPLLQSFTLPHQPA 778 Query: 526 PLASSPG------------PWGLEALAGGDLMPAPADPTAREGLAAPP-----RRLRSRK 568 P + PG L A L PA P A +G APP R+ R Sbjct: 779 PPDAGPGEREPRKEPRTAEKRPLRRGAEKSLPPAATGPGA-DGQPAPPWITVTRQKRRGT 837 Query: 569 VSCPLTRSNGDLSRSLSPSP 588 + P + + +R+L P Sbjct: 838 LDQPPNQEDKPGARTLKSEP 857 >gi|163965366 nascent polypeptide-associated complex alpha subunit isoform a [Homo sapiens] Length = 2078 Score = 53.9 bits (128), Expect = 6e-07 Identities = 84/360 (23%), Positives = 117/360 (32%), Gaps = 50/360 (13%) Query: 273 AAALQEAMKRLRGAKAFRLPGLSRREREPEP-----PAAVDFLEPDSGTCPEVDEEGFTV 327 A+ L E +G+K P + P P P+AV L P T P + T Sbjct: 833 ASFLPENSLSFQGSKDS--PATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKE----TP 886 Query: 328 RPDVT-----QNSTAEPSRFSSSDSDFDDEEPRKFYVHIKPAPARAPAC-SPEAAAAQLR 381 P V + A P+ + P+K PAP PA SP+ A Sbjct: 887 TPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKK--ARATPAPKGIPASPSPKGAPTPPA 944 Query: 382 ATAGS-----------------LILPPGPGGTMKRHSSRDA----AGKPQRPRSAPRTSS 420 AT S PP P G S + A A P P+ P T S Sbjct: 945 ATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPS 1004 Query: 421 CAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP 480 + G P + F G+S+ + PSP S + + +P Sbjct: 1005 PKGAPTPPAVTPPSPKGSPAATPFPK----GASTPPAATPPSPKGSPAATPLPKGAPTTP 1060 Query: 481 SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEAL- 539 + P P P +PP+ P P+ P P A+ P P G A Sbjct: 1061 AATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATP 1120 Query: 540 --AGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTA 597 G PA P+ + GLA PP + + G L+ +P P G+ A Sbjct: 1121 PHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLA---TPPPKGAPTTPAA 1177 Score = 48.5 bits (114), Expect = 3e-05 Identities = 56/219 (25%), Positives = 79/219 (36%), Gaps = 20/219 (9%) Query: 363 PAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCA 422 P+P +PA +P A A GP + + A P P+ P T S Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK 1100 Query: 423 ER----LQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSS-SSPENVEDS-- 475 + L PP + A T S G ++P P + ++P S Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1160 Query: 476 -GLDSP-------SHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDS--PQ 525 GL +P + AA PSP + P +P + A PP +G A P P Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220 Query: 526 PLASSPGPWG---LEALAGGDLMPAPADPTAREGLAAPP 561 P A+ P P G + G PA P+ + G A PP Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPP 1259 Score = 45.1 bits (105), Expect = 3e-04 Identities = 67/325 (20%), Positives = 109/325 (33%), Gaps = 41/325 (12%) Query: 332 TQNSTAEPSRFSSSDSDFDDEEPRKFYVHIKPAPARAP----ACSPEAAAAQLRATAGSL 387 T++S A + S + + P V + P R P + P+ L + + Sbjct: 772 TEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPV 831 Query: 388 ILPPGPGGTMKRHSSRDAAGK-----PQRPRSAPRTSSCAE------RLQSEEQVSKNLF 436 P ++ S+D+ P P+ AP S+ L +E + ++ Sbjct: 832 EASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVV 891 Query: 437 -------GPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSP 489 GP + + +SS + +P P + G +P A P PSP Sbjct: 892 NLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATP-PSP 950 Query: 490 DSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQ--PLASSPGPWGLEALA---GGDL 544 P +P A PP +G A P P P A+ P P G A G Sbjct: 951 KGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPT 1010 Query: 545 MPAPADPTAR---------EGLAAPPRRL----RSRKVSCPLTRSNGDLSRSLSPSPLGS 591 PA P+ + +G + PP + + PL + + PSP G Sbjct: 1011 PPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGG 1070 Query: 592 SAASTALERPSFLSQTGHGVSRGPS 616 A + P+ + T GP+ Sbjct: 1071 PATPSLKGAPTPPAATPPSPKGGPA 1095 Score = 43.1 bits (100), Expect = 0.001 Identities = 59/221 (26%), Positives = 79/221 (35%), Gaps = 44/221 (19%) Query: 363 PAPARAPAC-SPEAAAAQLRATA----GSLILPPGPGG----TMKRHSSRDAAGKPQRPR 413 P+P PA SP+ A AT G L PP G S + P P+ Sbjct: 1088 PSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPP-PK 1146 Query: 414 SAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSS-SSPENV 472 AP T + + L PP + A T S G ++PSP + ++P Sbjct: 1147 GAPTTPAA-----TPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT 1201 Query: 473 EDS---GLDSPSH-------AAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPD 522 S GL +PS AA PSP + P +P + A PP +G A P P Sbjct: 1202 PPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPP- 1260 Query: 523 SPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRR 563 G PA P+ + GLA PP + Sbjct: 1261 -----------------KGAPTPPAATPPSLKGGLATPPHK 1284 Score = 42.7 bits (99), Expect = 0.001 Identities = 61/266 (22%), Positives = 92/266 (34%), Gaps = 37/266 (13%) Query: 363 PAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCA 422 P+P +P P A A + PP P GT ++ ++ + P T S Sbjct: 1318 PSPKGSPGTPPPKGAPTPPA-----VTPPSPKGTPTLPATTPSS------KGGPTTPSSK 1366 Query: 423 ERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPEN----VEDSGLD 478 E + GP + S G +SP+ S + V G Sbjct: 1367 EGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAA 1426 Query: 479 SPSHAAPGP----------SPDSWVPR--PGTPQSPPSCRAPPPEARGIRAPPLP----- 521 +PS P +P + P+ P TP S P + PP P Sbjct: 1427 TPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVAT 1486 Query: 522 -DSPQPLASSPGPWG---LEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSN 577 SP+ ++P P G L A+ PA P++R AP L S+K L Sbjct: 1487 SSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKE 1546 Query: 578 GDLSRSLS-PSPLGSSAASTALERPS 602 + +++ PSP + A T E P+ Sbjct: 1547 ALIPPAMTVPSPKKTPAIPTPKEAPA 1572 Score = 42.4 bits (98), Expect = 0.002 Identities = 63/259 (24%), Positives = 93/259 (35%), Gaps = 53/259 (20%) Query: 372 SPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDA----AGKPQRPRSAPRTSSCAERLQS 427 SP+ A AT PP P G + S + A A P P+ P T Sbjct: 1213 SPKGAPTTPAAT------PPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPP-----PK 1261 Query: 428 EEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGP 487 P L+ G+ + + PSP P G +P A P P Sbjct: 1262 GAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSP--KGGPATSPPKGAPTPPAATP-P 1318 Query: 488 SPDSWVPRPGTPQSPPSCRAPPPEA--------------------RGIRAPPLPDSPQPL 527 SP G+P +PP AP P A G P + P P Sbjct: 1319 SPK------GSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPP 1372 Query: 528 ASSPGPWGLEALA-----GGDLMPAP-ADPTAREGLAAPPRRLRSRKVS--CPLTRSNGD 579 A++P G A+ G +P+P DPT+ + P++ + V+ T S GD Sbjct: 1373 AATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGD 1432 Query: 580 LS-RSLSPSPLGSSAASTA 597 L+ +++P L + A++A Sbjct: 1433 LTPPAVTPVSLKKAPATSA 1451 Score = 40.4 bits (93), Expect = 0.007 Identities = 62/251 (24%), Positives = 89/251 (35%), Gaps = 27/251 (10%) Query: 352 EEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQR 411 E P V +P +APA A L A ++P P SSR R Sbjct: 1477 EPPAPKQVATSSSPKKAPATPAPMGAPTLPA-----VIPSSPKEVPATPSSR-------R 1524 Query: 412 PRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPEN 471 AP + +++ + + L P + + + ++PS +SSP Sbjct: 1525 DPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPA 1584 Query: 472 VEDS---GLDSPSH-----AAPGPSP-DSWVPRPGTPQSPPSCRAPPPEARGIRAPP--- 519 V S G SP A PSP ++ P TP SP A P +PP Sbjct: 1585 VTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTP 1644 Query: 520 --LPDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSN 577 L DSP AS G +PA PTA + + P + ++ P TR Sbjct: 1645 SSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAP-TRKG 1703 Query: 578 GDLSRSLSPSP 588 +S + SP Sbjct: 1704 PQTKKSSATSP 1714 Score = 34.3 bits (77), Expect = 0.53 Identities = 120/597 (20%), Positives = 202/597 (33%), Gaps = 124/597 (20%) Query: 299 REPEPPAAVDFLEPDSGTCPEVDE---------EGFTVRPDV-TQNSTAEPSRFSSSDSD 348 +EP A P S P+ ++ F + D+ T ++ E + FS + + Sbjct: 491 KEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAG 550 Query: 349 FDDEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAA-- 406 ++ ++ AP +P+ ++T+ S +P P T+ + S + Sbjct: 551 LTTKKDPTVLPLVQAAPKNSPS---------FQSTSSSPEIPLSPEATLAKKSLGEPLPI 601 Query: 407 GKPQRPRSAPR-TSSCAERLQSEEQVSKNLFGPPLES--------AFDHEDF-------- 449 GKP ++P +S A ++++ + GP L+S AF E Sbjct: 602 GKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPT 661 Query: 450 TGSSSLGFTSSPSPFS----SSSPEN--VEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPP 503 T + +T++ SPF S +P+N V++ L + P P +P Sbjct: 662 TAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPL 721 Query: 504 SCRAPPPEA-RGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPR 562 + PE + + +P LP P + PG ++ ++ +A +A+ P+ Sbjct: 722 ATLVLAPEIPKSVPSPSLP----PAGTPPGTKKVDGIS---------HTSALAPVASSPK 768 Query: 563 RLRSRKVSCPLTRSNGDLSRSL--SPSPLGSSAASTALERPSFLSQTGHGVSRGPSPVVL 620 + T S+ L SPSPLG S + P T G + +P+ Sbjct: 769 ECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPP-----TKKGSAGPDTPIGN 823 Query: 621 GSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRL 680 S P+ +F F+G S PA S TPP P + Sbjct: 824 LSSPVSPVEASFLPENSLSFQGSKDS-------------PA---TTHSPTPPSPKGA--- 864 Query: 681 VHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEALQRQAEQNPTASYYNVVLLR 740 PS P + + + ++ PT S N+ + Sbjct: 865 -----------------PTPSAVTPLSP----------KGVTLPPKETPTPSVVNLPFPK 897 Query: 741 YQFSRPGPQSVP-LQLSAHWQCGATLTQVSVEYGYRPGATAVPTPLTNVQILLPVGEPVT 799 + P P+ P L +++ A T P PTP P G P T Sbjct: 898 EGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPS-PKGGPAT 956 Query: 800 NVRLQPAATWNLEEKRLTWRLPDVSEAGGSGR------LSASWEPLSGPSTPSPVAA 850 P+ W T P A S + + P GP+TPSP A Sbjct: 957 -----PSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGA 1008 Score = 32.7 bits (73), Expect = 1.5 Identities = 43/177 (24%), Positives = 67/177 (37%), Gaps = 14/177 (7%) Query: 361 IKPAPARAPACSPEAAAAQLRATA--GSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRT 418 + P+ + SP + ++ AT S LP G T + A P S P Sbjct: 1642 VTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPA-----PESTPII 1696 Query: 419 SSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLD 478 ++ + ++ S PP+ D GS T +P+P ++ + + Sbjct: 1697 TAPTRKGPQTKKSSAT--SPPI--CPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGK 1752 Query: 479 SPSHAAPGP--SPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGP 533 SH+ GP P+S P T + P PE+ + A P P PLA SP P Sbjct: 1753 DASHSPKGPLAPPESKASTPLTAAAFEKV-LPKPESASVSAAPSPPVSLPLAPSPVP 1808 >gi|157168329 formin 1 [Homo sapiens] Length = 1196 Score = 52.8 bits (125), Expect = 1e-06 Identities = 46/124 (37%), Positives = 53/124 (42%), Gaps = 21/124 (16%) Query: 445 DHEDF-------TGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPDSWVPRPG 497 DH+D G +S + P P +S P SGL S S A P P + P P Sbjct: 623 DHKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPP 682 Query: 498 TPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGL 557 P PP PPP + G PP P P PL +SP P GG P PA P GL Sbjct: 683 PPPPPPP--LPPPSSAG---PPPPPPPPPLPNSPAP----PNPGG---PPPAPPP--PGL 728 Query: 558 AAPP 561 A PP Sbjct: 729 APPP 732 Score = 32.3 bits (72), Expect = 2.0 Identities = 103/452 (22%), Positives = 152/452 (33%), Gaps = 104/452 (23%) Query: 132 QLLPKSRENYLN--RCMDQERLRRESTSQ-KEMDKAETKTKKAAESLRRSVEKYNSARAD 188 ++ PKS E L + + R+ +T+ E++ + K + ESLR E+ NS AD Sbjct: 392 EVKPKSPETALEAFKALFIRPPRKGTTADTSELEALKRKMRHEKESLRAVFERSNSKPAD 451 Query: 189 FEQKMLDSALRFQAMEETHLRHMKALLGSYAH-SVEDTHVQIG-------------QVHE 234 DS ++ E R L + +DT ++G + Sbjct: 452 GPS---DSKSPDHSLTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEAEYQAAILHLKR 508 Query: 235 EFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGL 294 E K+ IEN+ + LR F +G A A L+E ++ L+ R G Sbjct: 509 EHKEEIENLQAQFELRAF-HIRGE----------HAMITARLEETIENLKHELEHRWRG- 556 Query: 295 SRREREPEPPAAVDFLEPDS--GTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDE 352 ER+ + D P + C + D E F ++P +++ T ++ Sbjct: 557 GCEERKDVCISTDDDCPPKTFRNVCVQTDRETF-LKPCESESKTTRSNQLV--------- 606 Query: 353 EPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRP 412 P+K ++I +P + A L+ G +S P P Sbjct: 607 -PKK--LNISSLSQLSPPNDHKDIHAALQPMEGM--------------ASNQQKALPPPP 649 Query: 413 RSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSP--- 469 S P PPL S G SL P S+ P Sbjct: 650 ASIPPP-------------------PPLPS--------GLGSLSPAPPMPPVSAGPPLPP 682 Query: 470 ENVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLAS 529 L PS A P P P P P +P +PP+ PPP APP P LA Sbjct: 683 PPPPPPPLPPPSSAGPPPPPPP-PPLPNSP-APPNPGGPPP------APP----PPGLAP 730 Query: 530 SPGPWGLEALAGGDLMPAPADPTAREGLAAPP 561 P P GL G P P P Sbjct: 731 PPPP-GLFFGLGSSSSQCPRKPAIEPSCPMKP 761 >gi|239752265 PREDICTED: hypothetical protein XP_002348186 [Homo sapiens] Length = 225 Score = 51.6 bits (122), Expect = 3e-06 Identities = 50/155 (32%), Positives = 64/155 (41%), Gaps = 11/155 (7%) Query: 466 SSSPENVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPP-LPDSP 524 S SP++V S P SPDS VP PG SP S PP + PP PDS Sbjct: 52 SRSPDSVVPPPGSPDSVVLPPRSPDSVVPPPG---SPDSVVLPPRSPDSVVPPPRSPDSV 108 Query: 525 QPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSL 584 P SP L + ++P P P + + PP RS P RS R+ Sbjct: 109 VPPPGSPDSVVLPPRSPDSVVPPPGSP---DSVVLPP---RSPDSVVPPARSPDSGGRAG 162 Query: 585 SPSPLGSSAASTALERPSFLSQTGH-GVSRGPSPV 618 SP L AA+ A P + + G ++R P V Sbjct: 163 SPRSLAPPAAARAEGAPGWAGRWGRVPLARSPPQV 197 Score = 38.9 bits (89), Expect = 0.021 Identities = 63/226 (27%), Positives = 82/226 (36%), Gaps = 32/226 (14%) Query: 369 PACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQR-PRSAPRTSSCAERLQS 427 P+ SP++ R+ S++LPPG S D+ P R P S + + Sbjct: 21 PSRSPDSVVLPSRSP-DSVVLPPG---------SPDSVVLPSRSPDSVVPPPGSPDSVVL 70 Query: 428 EEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSP----SHA 483 + ++ PP GS SP S P DS + P S Sbjct: 71 PPRSPDSVVPPP-----------GSPDSVVLPPRSPDSVVPPPRSPDSVVPPPGSPDSVV 119 Query: 484 APGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGD 543 P SPDS VP PG SP S PP + P A SP A A + Sbjct: 120 LPPRSPDSVVPPPG---SPDSVVLPPRSPDSVVPPARSPDSGGRAGSPRSLAPPAAARAE 176 Query: 544 LMPAPADPTAREGLAAPPRRLRSR--KVSCPLTRSNGDLSRSLSPS 587 P A R LA P ++ SR +S PL+ S L L PS Sbjct: 177 GAPGWAGRWGRVPLARSPPQVPSRPPSLSQPLS-SRVSLYELLFPS 221 >gi|51702222 SPT2, Suppressor of Ty, domain containing 1 [Homo sapiens] Length = 685 Score = 50.8 bits (120), Expect = 5e-06 Identities = 122/527 (23%), Positives = 190/527 (36%), Gaps = 96/527 (18%) Query: 126 VLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMD-KAETKTKKAAESLRRSVEKYNS 184 V S Q K +E L R +E+ R+E +K ++ K + K + A+ + + YN Sbjct: 39 VQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNG 98 Query: 185 ARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNIENVS 244 + + K + QA E +H+ + T E++ EN Sbjct: 99 IPIEEKSK------KRQATE--------------SHTSQGTD-------REYEMEEEN-- 129 Query: 245 VEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRREREPEPP 304 E L AES+ E+ P E+ L+ A + RL +++ EP Sbjct: 130 -EFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLA--EKKQFEPVEI 186 Query: 305 AAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVHIKPA 364 V E T E+ E F R +K K Sbjct: 187 KVVKKSEERPMTAEELREREFLERK----------------------HRRKKLETDGKLP 224 Query: 365 PARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCAER 424 P + + + + + GS P G H+ + + + +SS + Sbjct: 225 PTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMP 284 Query: 425 LQSEEQVSKNLFGPPLESAFDHEDFTGSSSL-GFTSSPS-PFSSSSP------ENVEDSG 476 + + S N P L D F G+ TSSPS P +S+S E+ Sbjct: 285 GERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKS 344 Query: 477 LDSPSHAAPGP--SPDSWVPRPGTPQ-SPPSCRAPPPEARGIRAPPLPDSPQPL----AS 529 L PSH+ PGP +P + PG Q S AP + G+ P + P P +S Sbjct: 345 LSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSS 404 Query: 530 SPGPWGLEALAGGDLMPAPADPTAR--EGLAAPPRRLRSRKVSCPLTRSNG---DLSRSL 584 S GP +++G ++P+ R G P + P + S G +S S+ Sbjct: 405 SSGP--ERSISGSKKPTNDSNPSRRTVSGTCGPGQ---------PASSSGGPGRPISGSV 453 Query: 585 SPS-PLGSS-------AASTALERP-SFLSQTGHGVSRGPSPVVLGS 622 S + PLGSS ++ L RP S L G VS GP + GS Sbjct: 454 SSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVS-GPGRSISGS 499 >gi|157743252 pecanex-like 3 [Homo sapiens] Length = 2034 Score = 50.4 bits (119), Expect = 7e-06 Identities = 55/170 (32%), Positives = 66/170 (38%), Gaps = 38/170 (22%) Query: 445 DHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPS 504 D D +G L S+ P + +PEN +G D P PG P S + G + PP Sbjct: 1836 DDSDCSGGGGLTSLSNNPPVAHPTPENTAGNG-DQPLPPGPGWGPRSSLSGSGDGRPPPL 1894 Query: 505 CRAPPPEARGIRAPPLPDSPQP-------------LASSPGP---W---GLEALAGGDLM 545 + PPP G P P SP P L SS GP W G + L G D Sbjct: 1895 LQWPPPRLPG----PPPASPIPTEGPRTSRPPGPGLLSSEGPSGKWSLGGRKGLGGSDGE 1950 Query: 546 PAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAAS 595 PA P + K PL S LS SLS SP S+ AS Sbjct: 1951 PASGSPKG-----------GTPKSQAPLDLS---LSLSLSLSPDVSTEAS 1986 Score = 30.4 bits (67), Expect = 7.6 Identities = 69/288 (23%), Positives = 99/288 (34%), Gaps = 35/288 (12%) Query: 363 PAPARAPACSPEAAAAQLRATAGSLI----LPPGPGGTMKRHSSRDAAGKPQRPRSAPRT 418 P+ A + P A +GS + + P G++ + S+ Q R+ RT Sbjct: 207 PSLASTDSSEPSPLAGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFLTLTQPDRALVRT 266 Query: 419 SSCAERLQSE---EQVSKNLFGPPL-------ESAFDHEDFTGSSSLGFTSSPSPFSSSS 468 SS E+ + + + + G P +S F D SS + S S Sbjct: 267 SSRREQRRGAGGYQPLDRRGSGEPTPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSP 326 Query: 469 PENV--EDSGLDSPSHAAPGPSPDSWVPRPGTPQS---------PPSCRAP----PPEAR 513 P E S D PS A SPD+ VP T +S PP P P+ Sbjct: 327 PGGPAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDL 386 Query: 514 GIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRS-RKVSCP 572 + P P S PG L G D T+ +P LRS R+ S Sbjct: 387 ALLRPSKRQPPLRRHSPPGRAPRRPLLEGGGFFEDED-TSEGSELSPASSLRSQRRYSTD 445 Query: 573 LTRSNG----DLSRSLSPSPLGSSAASTALERPSFLSQTGHGVSRGPS 616 + S + SR + P A A E + + +G R PS Sbjct: 446 SSSSTSCYSPESSRGAAGGPRKRRAPHGAEEGTAVPPKRPYGTQRTPS 493 >gi|18959210 WIRE protein [Homo sapiens] Length = 440 Score = 50.4 bits (119), Expect = 7e-06 Identities = 85/341 (24%), Positives = 115/341 (33%), Gaps = 67/341 (19%) Query: 383 TAGSLILPPG---PGGTMK------RHSSRDAAGKPQRPRSAPRTSSCAERLQSEEQVSK 433 + G+ + P G GG +K + S + AGKP P + + A R Sbjct: 76 SGGAALQPKGGLFQGGVLKLRPVGAKDGSENLAGKPAL--QIPSSRAAAPR--------- 124 Query: 434 NLFGPPLESAFDH-EDFTGSS-----SLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGP 487 PP+ +A +D T SS L PS S P +G+ S A P P Sbjct: 125 ----PPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP 180 Query: 488 SPDSWVPRPGTPQSPPSCRAPP-------PEARGIRAPP---LPDSPQPLASSPGPWGLE 537 P P TP S +AP P G R P P +P P+ P P + Sbjct: 181 PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIR 240 Query: 538 ALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCP--------LTRSNGDLSRSLSPSPL 589 G + AP P R+ P S P L R R L+P P Sbjct: 241 TGPSGQSL-APPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPP 299 Query: 590 GSSAASTALER--PSFLSQTGHGVSRGPSPVVL--GSQDALPIATAFTEYVHAYFRGHSP 645 S++ S R P G + P P V+ G++DA P + G P Sbjct: 300 TSASPSLLSNRPPPPARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYR------MHGSEP 353 Query: 646 SCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAI 686 + P R +G PPPP R H +I Sbjct: 354 PSRGKP--------PPPPSRTPAGPPPPPPPPLRNGHRDSI 386 >gi|187829452 autism susceptibility candidate 2 isoform 2 [Homo sapiens] Length = 1235 Score = 50.1 bits (118), Expect = 9e-06 Identities = 55/203 (27%), Positives = 75/203 (36%), Gaps = 39/203 (19%) Query: 487 PSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMP 546 P P P P PQ+ P RAP P+ ++ P P PL++ P EA L P Sbjct: 298 PCPQVAQPIP-QPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEA----QLQP 352 Query: 547 APADPTAREGLAAPPRRL------------RSRKVSCPLTRSNGDLSRSLSPSPLGSSAA 594 AP R P +L ++ +S PL+ N S SLS + L SS + Sbjct: 353 APQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYN---SSSLSLNSLSSSRS 409 Query: 595 STALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGE 654 ST + H S P P+ L + L +FT + H P+ A T Sbjct: 410 STPAKTQPAPPHISHHPSASPFPLSLPNHSPL---HSFTPTLQPPAHSHHPNMFAPPT-- 464 Query: 655 LTMTFPAGIVRVFSGTPPPPVLS 677 PPPP L+ Sbjct: 465 --------------ALPPPPPLT 473 >gi|17864090 autism susceptibility candidate 2 isoform 1 [Homo sapiens] Length = 1259 Score = 50.1 bits (118), Expect = 9e-06 Identities = 55/203 (27%), Positives = 75/203 (36%), Gaps = 39/203 (19%) Query: 487 PSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMP 546 P P P P PQ+ P RAP P+ ++ P P PL++ P EA L P Sbjct: 298 PCPQVAQPIP-QPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEA----QLQP 352 Query: 547 APADPTAREGLAAPPRRL------------RSRKVSCPLTRSNGDLSRSLSPSPLGSSAA 594 AP R P +L ++ +S PL+ N S SLS + L SS + Sbjct: 353 APQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYN---SSSLSLNSLSSSRS 409 Query: 595 STALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGE 654 ST + H S P P+ L + L +FT + H P+ A T Sbjct: 410 STPAKTQPAPPHISHHPSASPFPLSLPNHSPL---HSFTPTLQPPAHSHHPNMFAPPT-- 464 Query: 655 LTMTFPAGIVRVFSGTPPPPVLS 677 PPPP L+ Sbjct: 465 --------------ALPPPPPLT 473 >gi|157074225 nuclear pore complex interacting protein-like 3 [Homo sapiens] Length = 678 Score = 50.1 bits (118), Expect = 9e-06 Identities = 69/256 (26%), Positives = 94/256 (36%), Gaps = 49/256 (19%) Query: 361 IKPAPARAPACSPEAAAAQLRATAGSLI--LPPGPGGTMKRHSSRDAAGKPQR--PRSAP 416 + P P A +P +A L+ A L+ LPP +K S R P P + Sbjct: 347 LTPLPPSALPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQLTPLPPSAPPSADD 406 Query: 417 RTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSG 476 + AERL+ GP SA D+ L +P S+P + +D+ Sbjct: 407 NIKTPAERLR----------GPLPPSADDNLKTPSERQL------TPLPPSAPPSADDN- 449 Query: 477 LDSPSHAAPGPSPDSWVPRPGTPQS------PPSCRAPPPEARGIRAP------PLPDSP 524 + +P+ GP P S TP PPS APP I+ P PLP S Sbjct: 450 IKTPAERLRGPLPPSADDNLKTPSERQLTPLPPS--APPSADDNIKTPAERLRGPLPPSA 507 Query: 525 QPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSL 584 +P L L P A P+A + + P RLR PL S D +L Sbjct: 508 DDNLKTPSERQLTPL------PPSAPPSADDNIKTPAERLRG-----PLPPSADD---NL 553 Query: 585 SPSPLGSSAASTALER 600 PL + A R Sbjct: 554 KTPPLATQEAEAEKPR 569 Score = 39.3 bits (90), Expect = 0.016 Identities = 60/246 (24%), Positives = 88/246 (35%), Gaps = 39/246 (15%) Query: 360 HIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTS 419 ++K P P +A L+ L+ P P + + P P + P Sbjct: 300 NLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSALPSAP 359 Query: 420 SCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDS 479 A+ + + ++ L P SA D+ L +P S+P + +D+ + + Sbjct: 360 PSAD--DNLKTRAECLLHPLPPSADDNLKTPSERQL------TPLPPSAPPSADDN-IKT 410 Query: 480 PSHAAPGPSPDSWVPRPGTPQS------PPSCRAPPPEARGIRAP------PLPDSPQPL 527 P+ GP P S TP PPS APP I+ P PLP S Sbjct: 411 PAERLRGPLPPSADDNLKTPSERQLTPLPPS--APPSADDNIKTPAERLRGPLPPSADDN 468 Query: 528 ASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGD-----LSR 582 +P L L P A P+A + + P RLR PL S D R Sbjct: 469 LKTPSERQLTPL------PPSAPPSADDNIKTPAERLRG-----PLPPSADDNLKTPSER 517 Query: 583 SLSPSP 588 L+P P Sbjct: 518 QLTPLP 523 >gi|150170670 piccolo isoform 2 [Homo sapiens] Length = 4935 Score = 49.7 bits (117), Expect = 1e-05 Identities = 73/314 (23%), Positives = 106/314 (33%), Gaps = 66/314 (21%) Query: 326 TVRPDVTQNSTAEPSRFSSSDSDFDDEEPRK------FYVHIKPAPARAPACSPEAAAAQ 379 T + D+ + + +PS S S P K + +P PA+ PA P Sbjct: 283 TKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPA-QPSGLTKP 341 Query: 380 LRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPP 439 L G++ P P GT K +P P P + +E+ SE+ K L PP Sbjct: 342 LAQQPGTVKPPVQPPGTTK------PPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPP 395 Query: 440 LESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAA---------PGPS-- 488 T + G P+ + + GL SP+ A PGP Sbjct: 396 GVGK------TPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKI 449 Query: 489 -------------------PDSWVPRPGTPQ-SPPSCRAPPPEARGIRAPPL-------- 520 P S +P P P P PPP+ G PP Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKP 509 Query: 521 -PDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGD 579 P P P SP G + P A P+A++ A P +S K P++++ Sbjct: 510 PPQQPGPAKPSPQQPG--STKPPSQQPGSAKPSAQQPSPAKPSAQQSTK---PVSQTGS- 563 Query: 580 LSRSLSPSPLGSSA 593 + L P + SA Sbjct: 564 -GKPLQPPTVSPSA 576 Score = 47.4 bits (111), Expect = 6e-05 Identities = 61/241 (25%), Positives = 84/241 (34%), Gaps = 39/241 (16%) Query: 295 SRREREPEPPAAVDFLEPDSGTCPEVD-----EEGFTVRPDVTQNSTAEPSRFSSS---- 345 S+ E + PP D +P P + + RP + P S S Sbjct: 785 SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQK 844 Query: 346 --DSDFDDEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSR 403 D EEP+K + P P P R TAG + P + S R Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRR 904 Query: 404 ---DAAGKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSS 460 + P+S P T +E V+ LFG F F+ +S+L T+ Sbjct: 905 FSLNLGSITDAPKSQPTTP--------QETVTGKLFG------FGASIFSQASNLISTAG 950 Query: 461 -PSPFSSSSPENVEDSGLDSPSHAAPGPS--PDSWVPRPGTPQSPPSCRAPPPEARGIRA 517 P P S S P +P AP PS P S P T Q+PP+ P + +A Sbjct: 951 QPGPHSQSGP--------GAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKA 1002 Query: 518 P 518 P Sbjct: 1003 P 1003 Score = 39.3 bits (90), Expect = 0.016 Identities = 72/270 (26%), Positives = 100/270 (37%), Gaps = 56/270 (20%) Query: 362 KPAPARAPACSPE---AAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRT 418 KPAP + P+ E A A + ++ P T SS A KP P S ++ Sbjct: 731 KPAPPKEPSVPSEQDKAPVADDKPKQPKMVKP-----TTDLVSSSSATTKPDIPSSKVQS 785 Query: 419 SSCAERLQSEEQVSKNLFGPPL--ESAFDHEDFTGSSSLGFTSSPSPFSSSS-PENVEDS 475 Q+EE+ + PPL +SA + F + SPF S + P DS Sbjct: 786 -------QAEEKTT-----PPLKTDSAKPSQSFPPTGE-----KVSPFDSKAIPRPASDS 828 Query: 476 GLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWG 535 + S PGPS +S G Q P + P+ + P PD+ SP P G Sbjct: 829 KIISH----PGPSSES----KGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPG 880 Query: 536 LEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSP------- 588 A G +P P +P + +SR+ S L S D +S +P Sbjct: 881 PRPTA-GQTVPTPQQ--------SPKPQEQSRRFSLNL-GSITDAPKSQPTTPQETVTGK 930 Query: 589 ---LGSSAASTALERPSFLSQTGHGVSRGP 615 G+S S A S Q G GP Sbjct: 931 LFGFGASIFSQASNLISTAGQPGPHSQSGP 960 Score = 32.3 bits (72), Expect = 2.0 Identities = 35/118 (29%), Positives = 44/118 (37%), Gaps = 16/118 (13%) Query: 422 AERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPS 481 AER +S +S+ +F P S S+ FTS + F P + SG S S Sbjct: 2328 AERTKSS--LSETVFDHPPSSVIALPMKEQLSTTYFTSGET-FGQEKPASQLPSGSPSVS 2384 Query: 482 HAAPGPSPD------SWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGP 533 P P +P P PP PPP PP P P P +SP P Sbjct: 2385 SLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPP-------PPPPPPPLPPPTSPKP 2435 Score = 30.8 bits (68), Expect = 5.8 Identities = 35/133 (26%), Positives = 46/133 (34%), Gaps = 28/133 (21%) Query: 406 AGKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFS 465 A + ++ A RT S + S ++ P++ FT + G S Sbjct: 2319 AYRDKKELEAERTKSSLSETVFDHPPS-SVIALPMKEQLSTTYFTSGETFGQEKPASQLP 2377 Query: 466 SSSPEN----------VEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGI 515 S SP S LD + P P P P P P PP PPP Sbjct: 2378 SGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPP----PPPPPPPPPP----PPP----- 2424 Query: 516 RAPPL--PDSPQP 526 PPL P SP+P Sbjct: 2425 --PPLPPPTSPKP 2435 >gi|150378539 piccolo isoform 1 [Homo sapiens] Length = 5142 Score = 49.7 bits (117), Expect = 1e-05 Identities = 73/314 (23%), Positives = 106/314 (33%), Gaps = 66/314 (21%) Query: 326 TVRPDVTQNSTAEPSRFSSSDSDFDDEEPRK------FYVHIKPAPARAPACSPEAAAAQ 379 T + D+ + + +PS S S P K + +P PA+ PA P Sbjct: 283 TKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPA-QPSGLTKP 341 Query: 380 LRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPP 439 L G++ P P GT K +P P P + +E+ SE+ K L PP Sbjct: 342 LAQQPGTVKPPVQPPGTTK------PPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPP 395 Query: 440 LESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAA---------PGPS-- 488 T + G P+ + + GL SP+ A PGP Sbjct: 396 GVGK------TPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKI 449 Query: 489 -------------------PDSWVPRPGTPQ-SPPSCRAPPPEARGIRAPPL-------- 520 P S +P P P P PPP+ G PP Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKP 509 Query: 521 -PDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGD 579 P P P SP G + P A P+A++ A P +S K P++++ Sbjct: 510 PPQQPGPAKPSPQQPG--STKPPSQQPGSAKPSAQQPSPAKPSAQQSTK---PVSQTGS- 563 Query: 580 LSRSLSPSPLGSSA 593 + L P + SA Sbjct: 564 -GKPLQPPTVSPSA 576 Score = 47.4 bits (111), Expect = 6e-05 Identities = 61/241 (25%), Positives = 84/241 (34%), Gaps = 39/241 (16%) Query: 295 SRREREPEPPAAVDFLEPDSGTCPEVD-----EEGFTVRPDVTQNSTAEPSRFSSS---- 345 S+ E + PP D +P P + + RP + P S S Sbjct: 785 SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQK 844 Query: 346 --DSDFDDEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSR 403 D EEP+K + P P P R TAG + P + S R Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRR 904 Query: 404 ---DAAGKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSS 460 + P+S P T +E V+ LFG F F+ +S+L T+ Sbjct: 905 FSLNLGSITDAPKSQPTTP--------QETVTGKLFG------FGASIFSQASNLISTAG 950 Query: 461 -PSPFSSSSPENVEDSGLDSPSHAAPGPS--PDSWVPRPGTPQSPPSCRAPPPEARGIRA 517 P P S S P +P AP PS P S P T Q+PP+ P + +A Sbjct: 951 QPGPHSQSGP--------GAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKA 1002 Query: 518 P 518 P Sbjct: 1003 P 1003 Score = 39.3 bits (90), Expect = 0.016 Identities = 72/270 (26%), Positives = 100/270 (37%), Gaps = 56/270 (20%) Query: 362 KPAPARAPACSPE---AAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRT 418 KPAP + P+ E A A + ++ P T SS A KP P S ++ Sbjct: 731 KPAPPKEPSVPSEQDKAPVADDKPKQPKMVKP-----TTDLVSSSSATTKPDIPSSKVQS 785 Query: 419 SSCAERLQSEEQVSKNLFGPPL--ESAFDHEDFTGSSSLGFTSSPSPFSSSS-PENVEDS 475 Q+EE+ + PPL +SA + F + SPF S + P DS Sbjct: 786 -------QAEEKTT-----PPLKTDSAKPSQSFPPTGE-----KVSPFDSKAIPRPASDS 828 Query: 476 GLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWG 535 + S PGPS +S G Q P + P+ + P PD+ SP P G Sbjct: 829 KIISH----PGPSSES----KGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPG 880 Query: 536 LEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSP------- 588 A G +P P +P + +SR+ S L S D +S +P Sbjct: 881 PRPTA-GQTVPTPQQ--------SPKPQEQSRRFSLNL-GSITDAPKSQPTTPQETVTGK 930 Query: 589 ---LGSSAASTALERPSFLSQTGHGVSRGP 615 G+S S A S Q G GP Sbjct: 931 LFGFGASIFSQASNLISTAGQPGPHSQSGP 960 Score = 32.3 bits (72), Expect = 2.0 Identities = 35/118 (29%), Positives = 44/118 (37%), Gaps = 16/118 (13%) Query: 422 AERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPS 481 AER +S +S+ +F P S S+ FTS + F P + SG S S Sbjct: 2328 AERTKSS--LSETVFDHPPSSVIALPMKEQLSTTYFTSGET-FGQEKPASQLPSGSPSVS 2384 Query: 482 HAAPGPSPD------SWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGP 533 P P +P P PP PPP PP P P P +SP P Sbjct: 2385 SLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPP-------PPPPPPPLPPPTSPKP 2435 Score = 30.8 bits (68), Expect = 5.8 Identities = 35/133 (26%), Positives = 46/133 (34%), Gaps = 28/133 (21%) Query: 406 AGKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFS 465 A + ++ A RT S + S ++ P++ FT + G S Sbjct: 2319 AYRDKKELEAERTKSSLSETVFDHPPS-SVIALPMKEQLSTTYFTSGETFGQEKPASQLP 2377 Query: 466 SSSPEN----------VEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGI 515 S SP S LD + P P P P P P PP PPP Sbjct: 2378 SGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPP----PPPPPPPPPP----PPP----- 2424 Query: 516 RAPPL--PDSPQP 526 PPL P SP+P Sbjct: 2425 --PPLPPPTSPKP 2435 >gi|33356148 formin-like 1 [Homo sapiens] Length = 1100 Score = 49.3 bits (116), Expect = 2e-05 Identities = 54/168 (32%), Positives = 69/168 (41%), Gaps = 34/168 (20%) Query: 405 AAGKPQRPRSAPR---TSSCAERLQSEEQVSKNLF----GPPLESAFDHEDFT-GSSSLG 456 A+ +P P AP T A L+ EE K L GP + + + S G Sbjct: 455 ASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGG 514 Query: 457 FTSSPS-PFSSSSPENVEDSGLDSPSHAAPGPSPDSWVPRPGTP---QSPPSCRAPPPEA 512 +P P S SP+ L + APG +P P PG P ++PPS APP Sbjct: 515 DAPTPGVPTGSPSPD------LAPAAEPAPGAAPPPPPPLPGLPSPQEAPPS--APP--- 563 Query: 513 RGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAP 560 +APPLP SP+P + P P GDL P P P G P Sbjct: 564 ---QAPPLPGSPEPPPAPPLP--------GDLPPPPPPPPPPPGTDGP 600 Score = 39.7 bits (91), Expect = 0.013 Identities = 30/99 (30%), Positives = 37/99 (37%), Gaps = 14/99 (14%) Query: 450 TGSSSLGFTSSPSPFSSSSPENVED-SGLDSPSHAAPGPSPDSWVPRPGTPQSPPSC--- 505 TGS S + P ++P GL SP A P P + P PG+P+ PP+ Sbjct: 523 TGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQA-PPLPGSPEPPPAPPLP 581 Query: 506 ---------RAPPPEARGIRAPPLPDSPQPLASSPGPWG 535 PPP G PP P P P P G Sbjct: 582 GDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALG 620 >gi|223972704 hypothetical protein LOC284418 [Homo sapiens] Length = 922 Score = 48.5 bits (114), Expect = 3e-05 Identities = 109/455 (23%), Positives = 158/455 (34%), Gaps = 125/455 (27%) Query: 481 SHAAPGPSPDSWVPRPGT--PQSPPSCRAPPPEARGI-----RAPPLPDSPQPLASSPGP 533 S P SW P PG PQ P+ APP +A + +AP +P Q + P P Sbjct: 419 SQKLPAVPASSWKPPPGLAPPQKAPAASAPPRKAPAVPAPSQKAPAVPAPSQKAPAIPAP 478 Query: 534 WGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSA 593 A A P + APP++ P P+ + Sbjct: 479 -------SRKASAASASPRKASAVPAPPQKTPPPSQKAPSV-----------PTIPQKAV 520 Query: 594 ASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTG 653 + TA ++ S L P+P SQ ALP T+ TEY A P+ ++ G Sbjct: 521 SPTAPKKKSLLL---------PAP----SQKALP--TSPTEYQMAL---SPPASRGKLPG 562 Query: 654 ELTMTFPAGI------VRVFSGTPPPPVLSFRLVHTTAIEHF--------------QPNA 693 + + P GI R SG P PV++ R T +E + + Sbjct: 563 DFDV-LPTGIPGRAVLERSQSGGKPEPVVTVRTQETDVVEMTTQAKSPESPFTVTKKESK 621 Query: 694 DLLFSDPSQSDPET------KDFWLNMAALTE--------------------ALQRQAEQ 727 D+L S + E + W + A L E + A + Sbjct: 622 DILISQTKEVTLEAFRGQGKLEDWAHWAKLEERSPDLPGVRSKELEQRKRWVKAKELAVE 681 Query: 728 NPTASY---YNVVLL-----------RYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYG 773 P+ + ++V L + Q S+ S+P L A Q AT SV Sbjct: 682 GPSQEHSRPFSVEALTLTKLMITANSKEQPSKSALVSLPSWLLATPQASATSMMASVP-- 739 Query: 774 YRPGATAVPTPLTNVQILLPVGEPVTNVRLQPAA-TWNLEEKRLTWRLPDVSEAGGSGRL 832 RPG Q+ L G+PV VR QP + TW E KR W ++ E Sbjct: 740 SRPG-----------QLSLLEGKPVV-VREQPESHTWVKEGKR-PW--GEMKEQPWGEMK 784 Query: 833 SASWEPLSGPSTP---SPVAAQFTSEGTTLSGVDL 864 W+P P P P +A EG + + + L Sbjct: 785 EPPWDPKGPPKVPFRSKPTSASLKREGISQAPIPL 819 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.129 0.382 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 40,912,717 Number of Sequences: 37866 Number of extensions: 2437987 Number of successful extensions: 19792 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 238 Number of HSP's successfully gapped in prelim test: 1496 Number of HSP's that attempted gapping in prelim test: 12409 Number of HSP's gapped (non-prelim): 5967 length of query: 889 length of database: 18,247,518 effective HSP length: 111 effective length of query: 778 effective length of database: 14,044,392 effective search space: 10926536976 effective search space used: 10926536976 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.