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Search of human proteins with 29725609
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29725609 epidermal growth factor receptor isoform a
precursor [Homo sapiens]
(1210 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29725609 epidermal growth factor receptor isoform a precursor... 2518 0.0
gi|41327736 epidermal growth factor receptor isoform d precursor... 1334 0.0
gi|41327732 epidermal growth factor receptor isoform b precursor... 1334 0.0
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 1267 0.0
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 1263 0.0
gi|54792096 erbB-2 isoform a [Homo sapiens] 1198 0.0
gi|54792098 erbB-2 isoform b [Homo sapiens] 1186 0.0
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 984 0.0
gi|41327734 epidermal growth factor receptor isoform c precursor... 847 0.0
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 215 2e-55
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 215 2e-55
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 209 1e-53
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 205 2e-52
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 204 5e-52
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 204 5e-52
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 203 7e-52
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 203 7e-52
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 202 1e-51
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 201 3e-51
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 201 3e-51
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 201 3e-51
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 201 3e-51
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 201 3e-51
gi|221316650 ephrin receptor EphA1 [Homo sapiens] 199 1e-50
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 199 1e-50
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 199 1e-50
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 199 1e-50
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 198 3e-50
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 198 3e-50
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 198 3e-50
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 2518 bits (6525), Expect = 0.0
Identities = 1210/1210 (100%), Positives = 1210/1210 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
Query: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
Sbjct: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
Query: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
Sbjct: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
Query: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
Sbjct: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
Query: 601 GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV 660
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
Sbjct: 601 GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV 660
Query: 661 ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS 720
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
Sbjct: 661 ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS 720
Query: 721 GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI 780
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
Sbjct: 721 GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI 780
Query: 781 CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA 840
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
Sbjct: 781 CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA 840
Query: 841 RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY 900
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
Sbjct: 841 RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY 900
Query: 901 GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK 960
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
Sbjct: 901 GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK 960
Query: 961 FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ 1020
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
Sbjct: 961 FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ 1020
Query: 1021 QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED 1080
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
Sbjct: 1021 QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED 1080
Query: 1081 SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN 1140
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
Sbjct: 1081 SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN 1140
Query: 1141 TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV 1200
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
Sbjct: 1141 TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV 1200
Query: 1201 APQSSEFIGA 1210
APQSSEFIGA
Sbjct: 1201 APQSSEFIGA 1210
>gi|41327736 epidermal growth factor receptor isoform d precursor
[Homo sapiens]
Length = 705
Score = 1334 bits (3453), Expect = 0.0
Identities = 630/634 (99%), Positives = 630/634 (99%), Gaps = 3/634 (0%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
Query: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
Sbjct: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
Query: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
Sbjct: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
Query: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
Sbjct: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
Query: 601 GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLE 634
GENNTLVWKYADAGHVCHLCHPNCTY GPG E
Sbjct: 601 GENNTLVWKYADAGHVCHLCHPNCTY---GPGNE 631
Score = 64.3 bits (155), Expect = 7e-10
Identities = 79/316 (25%), Positives = 113/316 (35%), Gaps = 108/316 (34%)
Query: 334 RKVCNGIG-----IGEFKDS-LSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPL 387
+KVC G +G F+D LS+ + F NC + G+L I V D
Sbjct: 28 KKVCQGTSNKLTQLGTFEDHFLSLQ----RMFNNCEVVLGNLEITYVQRNYD-------- 75
Query: 388 DPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVS----- 442
L LKT++E+ G++LI N + ENL+IIRG ++LAV+S
Sbjct: 76 ----LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVLSNYDAN 128
Query: 443 -LNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKA 501
+ L +R+L+EI G V S N
Sbjct: 129 KTGLKELPMRNLQEILHGAVRFSNNP---------------------------------- 154
Query: 502 TGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVEN-SECIQCHP 560
ALC+ E + RD VS + L +F + C +C P
Sbjct: 155 ------ALCNVESI---QWRDIVSS-------------DFLSNMSMDFQNHLGSCQKCDP 192
Query: 561 ECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLC 620
C N +C G G +NC + I C + C G++ + C
Sbjct: 193 SC----PNGSCWGAGEENCQKLTKII----CAQQCSGRCRGKSPS------------DCC 232
Query: 621 HPNCTYGCTGPGLEGC 636
H C GCTGP C
Sbjct: 233 HNQCAAGCTGPRESDC 248
>gi|41327732 epidermal growth factor receptor isoform b precursor
[Homo sapiens]
Length = 628
Score = 1334 bits (3452), Expect = 0.0
Identities = 627/627 (100%), Positives = 627/627 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
Query: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
Sbjct: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
Query: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
Sbjct: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
Query: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
Sbjct: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
Query: 601 GENNTLVWKYADAGHVCHLCHPNCTYG 627
GENNTLVWKYADAGHVCHLCHPNCTYG
Sbjct: 601 GENNTLVWKYADAGHVCHLCHPNCTYG 627
Score = 64.3 bits (155), Expect = 7e-10
Identities = 79/316 (25%), Positives = 113/316 (35%), Gaps = 108/316 (34%)
Query: 334 RKVCNGIG-----IGEFKDS-LSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPL 387
+KVC G +G F+D LS+ + F NC + G+L I V D
Sbjct: 28 KKVCQGTSNKLTQLGTFEDHFLSLQ----RMFNNCEVVLGNLEITYVQRNYD-------- 75
Query: 388 DPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVS----- 442
L LKT++E+ G++LI N + ENL+IIRG ++LAV+S
Sbjct: 76 ----LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVLSNYDAN 128
Query: 443 -LNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKA 501
+ L +R+L+EI G V S N
Sbjct: 129 KTGLKELPMRNLQEILHGAVRFSNNP---------------------------------- 154
Query: 502 TGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVEN-SECIQCHP 560
ALC+ E + RD VS + L +F + C +C P
Sbjct: 155 ------ALCNVESI---QWRDIVSS-------------DFLSNMSMDFQNHLGSCQKCDP 192
Query: 561 ECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLC 620
C N +C G G +NC + I C + C G++ + C
Sbjct: 193 SC----PNGSCWGAGEENCQKLTKII----CAQQCSGRCRGKSPS------------DCC 232
Query: 621 HPNCTYGCTGPGLEGC 636
H C GCTGP C
Sbjct: 233 HNQCAAGCTGPRESDC 248
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 1267 bits (3279), Expect = 0.0
Identities = 643/1251 (51%), Positives = 815/1251 (65%), Gaps = 83/1251 (6%)
Query: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
Query: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
Query: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
Query: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
Query: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
Query: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443
+DP++L++ +TV+EITGFL IQ+WP N TD F NL I GR G L +
Sbjct: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
Query: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503
ITSL +SLKEIS G++ I+ N NLCY +TINW LF T Q+ I NR +C A G
Sbjct: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
Query: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563
VC+ LCS +GCWGP P C+SCR SRGR C++ CNL +GE REF S C++C P+C
Sbjct: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
Query: 564 PQAMNI-TCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622
+ TC G GPDNC +C+H+ DGP+CV+ CP G+ G N+ ++KYAD CH CHP
Sbjct: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANS-FIFKYADPDRECHPCHP 619
Query: 623 NCTYGCTGPGLEGC---PTNG-------PKIPSIATGMVGALLLLLVVALGIGLFMRRRH 672
NCT GC GP C P G + P IA G++G L +L++V L +++RR+
Sbjct: 620 NCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKS 679
Query: 673 IVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWI 732
I +KR LRR L E ELVEPLTPSG APNQA LRILKETE K++KVLGSGAFGTVYKG+W+
Sbjct: 680 IKKKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWV 738
Query: 733 PEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQL 792
PEGE VKIPVAIK L E T PKAN E +DEA +MAS+D+PH+ RLLG+CL+ T+QL+TQL
Sbjct: 739 PEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQL 798
Query: 793 MPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK 852
MP GCLL+YV EHKDNIGSQ LLNWCVQIAKGM YLE+RRLVHRDLAARNVLVK+P HVK
Sbjct: 799 MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVK 858
Query: 853 ITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 912
ITDFGLA+LL +EKEY+A+GGK+PIKWMALE I +R +THQSDVWSYGVT+WELMTFG
Sbjct: 859 ITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGG 918
Query: 913 KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMA 972
KPYDGIP EI +LEKGERLPQPPICTIDVYM+MVKCWMIDADSRPKF+EL EFS+MA
Sbjct: 919 KPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMA 978
Query: 973 RDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ------------ 1020
RDPQRYLVIQGD+RM LPSP DS F++ L+DEED++D++DA+EYL+PQ
Sbjct: 979 RDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSR 1038
Query: 1021 -------------QGFFSSPSTSRTPLLSSLSA-----TSNNSTVACIDR---NGLQSCP 1059
G F++ P + S + +T D NG P
Sbjct: 1039 ARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKP 1098
Query: 1060 ----IKEDSFLQRYSSDPT---------GALTEDSIDDTF--LPVPEYI-----NQSVPK 1099
++EDS QRYS+DPT G L E+ P EY+ N V +
Sbjct: 1099 VAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSR 1158
Query: 1100 RPAGSVQ---NPVYHNQPLNPAPSRD-----PHYQDPHSTAVGNPEYLNT---VQPTCVN 1148
R G +Q NP YHN P + D P Y + + +G EYL P
Sbjct: 1159 RKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAK 1218
Query: 1149 STFDSPAHWAQKGSHQISLDNPDYQQDFFPKE-AKPNGIFKGSTAENAEYL 1198
FD+P +W + +L +PDY Q++ K K NG + AEN EYL
Sbjct: 1219 KAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYL 1269
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 1263 bits (3269), Expect = 0.0
Identities = 645/1267 (50%), Positives = 817/1267 (64%), Gaps = 99/1267 (7%)
Query: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
Query: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
Query: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
Query: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
Query: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
Query: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443
+DP++L++ +TV+EITGFL IQ+WP N TD F NL I GR G L +
Sbjct: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
Query: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503
ITSL +SLKEIS G++ I+ N NLCY +TINW LF T Q+ I NR +C A G
Sbjct: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
Query: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563
VC+ LCS +GCWGP P C+SCR SRGR C++ CNL +GE REF S C++C P+C
Sbjct: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
Query: 564 PQAMNI-TCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622
+ TC G GPDNC +C+H+ DGP+CV+ CP G+ G N+ ++KYAD CH CHP
Sbjct: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANS-FIFKYADPDRECHPCHP 619
Query: 623 NCTYGCTGPGLEGC---PTNG-------PKIPSIATGMVGALLLLLVVALGIGLFMRRRH 672
NCT GC GP C P G + P IA G++G L +L++V L +++RR+
Sbjct: 620 NCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKS 679
Query: 673 IVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWI 732
I +KR LRR L E ELVEPLTPSG APNQA LRILKETE K++KVLGSGAFGTVYKG+W+
Sbjct: 680 IKKKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWV 738
Query: 733 PEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQL 792
PEGE VKIPVAIK L E T PKAN E +DEA +MAS+D+PH+ RLLG+CL+ T+QL+TQL
Sbjct: 739 PEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQL 798
Query: 793 MPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK 852
MP GCLL+YV EHKDNIGSQ LLNWCVQIAKGM YLE+RRLVHRDLAARNVLVK+P HVK
Sbjct: 799 MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVK 858
Query: 853 ITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 912
ITDFGLA+LL +EKEY+A+GGK+PIKWMALE I +R +THQSDVWSYGVT+WELMTFG
Sbjct: 859 ITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGG 918
Query: 913 KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMA 972
KPYDGIP EI +LEKGERLPQPPICTIDVYM+MVKCWMIDADSRPKF+EL EFS+MA
Sbjct: 919 KPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMA 978
Query: 973 RDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSP-STSR 1031
RDPQRYLVIQGD+RM LPSP DS F++ L+DEED++D++DA+EYL+PQ P TSR
Sbjct: 979 RDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSR 1038
Query: 1032 TPLLSSLSATSNNSTVACIDRNGLQ----------------------------------- 1056
+ S+ S ++ A +G Q
Sbjct: 1039 ARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGAT 1098
Query: 1057 ------SC-----------PIKEDSFLQRYSSDPT---------GALTEDSIDDTF--LP 1088
SC ++EDS QRYS+DPT G L E+ P
Sbjct: 1099 AEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKP 1158
Query: 1089 VPEYI-----NQSVPKRPAGSVQ---NPVYHNQPLNPAPSRD-----PHYQDPHSTAVGN 1135
EY+ N V +R G +Q NP YHN P + D P Y + + +G
Sbjct: 1159 KQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGK 1218
Query: 1136 PEYLNT---VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKE-AKPNGIFKGST 1191
EYL P FD+P +W + +L +PDY Q++ K K NG +
Sbjct: 1219 AEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIV 1278
Query: 1192 AENAEYL 1198
AEN EYL
Sbjct: 1279 AENPEYL 1285
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 1198 bits (3099), Expect = 0.0
Identities = 628/1252 (50%), Positives = 802/1252 (64%), Gaps = 80/1252 (6%)
Query: 14 LLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRN 73
LL AL P A +VC GT KL + E H L+ ++ C+VV GNLE+TY+ N
Sbjct: 11 LLLALLPPGAA--STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN 68
Query: 74 YDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYD------- 126
LSFL+ IQEV GYVLIA N V ++PL+ L+I+RG +E++YALAVL N D
Sbjct: 69 ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTP 128
Query: 127 ---ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNH 183
A+ GL+EL +R+L EIL G V NP LC ++I W+DI + +++ N
Sbjct: 129 VTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNR 188
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
+C C P C CWG E+CQ LT+ +CA C+ RC+G P+DCCH QCAAGCTGP
Sbjct: 189 SRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA-RCKGPLPTDCCHEQCAAGCTGP 247
Query: 244 RESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTD 303
+ SDCL C F C+ CP L+ YN T++ NPEG+Y+FGA+CV CP NY+ TD
Sbjct: 248 KHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTD 307
Query: 304 HGSCVRACGADSYEME-EDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNC 362
GSC C + E+ EDG ++C+KC PC +VC G+G+ ++ ++ + NI+ F C
Sbjct: 308 VGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGC 367
Query: 363 TSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFEN 422
I G L LP +F GD ++T PL P++L + +T++EITG+L I AWP++ DL F+N
Sbjct: 368 KKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQN 427
Query: 423 LEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFG 482
L++IRGR +G +SL + L I+ LGLRSL+E+ G +I N +LC+ +T+ W +LF
Sbjct: 428 LQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFR 487
Query: 483 TSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLL 542
Q +NR E+ C G CH LC+ CWGP P CV+C RG+ECV++C +L
Sbjct: 488 NPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVL 547
Query: 543 EGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGE 602
+G PRE+V C+ CHPEC PQ ++TC G D C+ CAHY D P CV CP+GV +
Sbjct: 548 QGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPD 607
Query: 603 NNTL-VWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIP--SIATGMVGALLLLLV 659
+ + +WK+ D C C NCT+ C +GCP P SI + +VG LL++++
Sbjct: 608 LSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVL 667
Query: 660 -VALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVL 718
V GI L RR+ +RK T+RRLLQE ELVEPLTPSG PNQA +RILKETE +K+KVL
Sbjct: 668 GVVFGI-LIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVL 726
Query: 719 GSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLL 778
GSGAFGTVYKG+WIP+GE VKIPVAIK LRE TSPKANKEILDEAYVMA V +P+V RLL
Sbjct: 727 GSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLL 786
Query: 779 GICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDL 838
GICLTSTVQL+TQLMP+GCLLD+VRE++ +GSQ LLNWC+QIAKGM+YLED RLVHRDL
Sbjct: 787 GICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDL 846
Query: 839 AARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVW 898
AARNVLVK+P HVKITDFGLA+LL +E EYHA+GGKVPIKWMALESIL R +THQSDVW
Sbjct: 847 AARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVW 906
Query: 899 SYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSR 958
SYGVTVWELMTFG+KPYDGIPA EI +LEKGERLPQPPICTIDVYMIMVKCWMID++ R
Sbjct: 907 SYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECR 966
Query: 959 PKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLI 1018
P+FREL+ EFS+MARDPQR++VIQ +E + SP DS FYR+L++++DM D+VDA+EYL+
Sbjct: 967 PRFRELVSEFSRMARDPQRFVVIQ-NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLV 1025
Query: 1019 PQQGFF----------------------------------SSPSTSRTPLLSSLSATSN- 1043
PQQGFF S R+PL S A S+
Sbjct: 1026 PQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDV 1085
Query: 1044 -NSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDS----IDDTFLPVPEYINQ-SV 1097
+ + GLQS P + S LQRYS DPT L ++ T P PEY+NQ V
Sbjct: 1086 FDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDV 1145
Query: 1098 PKRPAGSVQNPVYHNQPLNP--------APSRDPHYQD--PHSTAVGNPEYLNTVQPTCV 1147
+P + P+ +P +P ++ +D AV NPEYL T Q
Sbjct: 1146 RPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYL-TPQGGAA 1204
Query: 1148 NSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGS-TAENAEYL 1198
PA + DN Y P+ P FKG+ TAEN EYL
Sbjct: 1205 PQPHPPPA-------FSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYL 1249
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 1186 bits (3068), Expect = 0.0
Identities = 616/1221 (50%), Positives = 788/1221 (64%), Gaps = 78/1221 (6%)
Query: 45 EDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENL 104
E H L+ ++ C+VV GNLE+TY+ N LSFL+ IQEV GYVLIA N V ++PL+ L
Sbjct: 10 ETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRL 69
Query: 105 QIIRGNMYYENSYALAVLSNYD----------ANKTGLKELPMRNLQEILHGAVRFSNNP 154
+I+RG +E++YALAVL N D A+ GL+EL +R+L EIL G V NP
Sbjct: 70 RIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNP 129
Query: 155 ALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKII 214
LC ++I W+DI + +++ N +C C P C CWG E+CQ LT+ +
Sbjct: 130 QLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTV 189
Query: 215 CAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTT 274
CA C+ RC+G P+DCCH QCAAGCTGP+ SDCL C F C+ CP L+ YN T
Sbjct: 190 CAGGCA-RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDT 248
Query: 275 YQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEME-EDGVRKCKKCEGPC 333
++ NPEG+Y+FGA+CV CP NY+ TD GSC C + E+ EDG ++C+KC PC
Sbjct: 249 FESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPC 308
Query: 334 RKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELD 393
+VC G+G+ ++ ++ + NI+ F C I G L LP +F GD ++T PL P++L
Sbjct: 309 ARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQ 368
Query: 394 ILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSL 453
+ +T++EITG+L I AWP++ DL F+NL++IRGR +G +SL + L I+ LGLRSL
Sbjct: 369 VFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSL 428
Query: 454 KEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPE 513
+E+ G +I N +LC+ +T+ W +LF Q +NR E+ C G CH LC+
Sbjct: 429 RELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARG 488
Query: 514 GCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTG 573
CWGP P CV+C RG+ECV++C +L+G PRE+V C+ CHPEC PQ ++TC G
Sbjct: 489 HCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFG 548
Query: 574 RGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTL-VWKYADAGHVCHLCHPNCTYGCTGPG 632
D C+ CAHY D P CV CP+GV + + + +WK+ D C C NCT+ C
Sbjct: 549 PEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLD 608
Query: 633 LEGCPTNGPKIP--SIATGMVGALLLLLV-VALGIGLFMRRRHIVRKRTLRRLLQERELV 689
+GCP P SI + +VG LL++++ V GI L RR+ +RK T+RRLLQE ELV
Sbjct: 609 DKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGI-LIKRRQQKIRKYTMRRLLQETELV 667
Query: 690 EPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE 749
EPLTPSG PNQA +RILKETE +K+KVLGSGAFGTVYKG+WIP+GE VKIPVAIK LRE
Sbjct: 668 EPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRE 727
Query: 750 ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNI 809
TSPKANKEILDEAYVMA V +P+V RLLGICLTSTVQL+TQLMP+GCLLD+VRE++ +
Sbjct: 728 NTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRL 787
Query: 810 GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY 869
GSQ LLNWC+QIAKGM+YLED RLVHRDLAARNVLVK+P HVKITDFGLA+LL +E EY
Sbjct: 788 GSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEY 847
Query: 870 HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEK 929
HA+GGKVPIKWMALESIL R +THQSDVWSYGVTVWELMTFG+KPYDGIPA EI +LEK
Sbjct: 848 HADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEK 907
Query: 930 GERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHL 989
GERLPQPPICTIDVYMIMVKCWMID++ RP+FREL+ EFS+MARDPQR++VIQ +E +
Sbjct: 908 GERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQ-NEDLGP 966
Query: 990 PSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFF------------------------- 1024
SP DS FYR+L++++DM D+VDA+EYL+PQQGFF
Sbjct: 967 ASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGG 1026
Query: 1025 ---------SSPSTSRTPLLSSLSATSN--NSTVACIDRNGLQSCPIKEDSFLQRYSSDP 1073
S R+PL S A S+ + + GLQS P + S LQRYS DP
Sbjct: 1027 GDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDP 1086
Query: 1074 TGALTEDS----IDDTFLPVPEYINQ-SVPKRPAGSVQNPVYHNQPLNP--------APS 1120
T L ++ T P PEY+NQ V +P + P+ +P +P
Sbjct: 1087 TVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPG 1146
Query: 1121 RDPHYQD--PHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFP 1178
++ +D AV NPEYL T Q PA + DN Y P
Sbjct: 1147 KNGVVKDVFAFGGAVENPEYL-TPQGGAAPQPHPPPA-------FSPAFDNLYYWDQDPP 1198
Query: 1179 KEAKPNGIFKGS-TAENAEYL 1198
+ P FKG+ TAEN EYL
Sbjct: 1199 ERGAPPSTFKGTPTAENPEYL 1219
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 984 bits (2543), Expect = 0.0
Identities = 479/1013 (47%), Positives = 653/1013 (64%), Gaps = 18/1013 (1%)
Query: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
Query: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
Query: 131 -GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQK 189
L++L + L EIL G V N LC++++I WRDIV + + +++ SC
Sbjct: 129 HALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPP 185
Query: 190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCL 249
C C G CWG G E+CQ LTK ICA QC+G C G +P+ CCH++CA GC+GP+++DC
Sbjct: 186 CHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCF 244
Query: 250 VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVR 309
CR F D C CP ++YN T+Q++ NP KY +G CV CP N+VV D SCVR
Sbjct: 245 ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVR 303
Query: 310 ACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDL 369
AC D E++++G++ C+ C G C K C G G G + ++++NI F NCT I G+L
Sbjct: 304 ACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQT--VDSSNIDGFVNCTKILGNL 361
Query: 370 HILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGR 429
L GD + P LDP++L++ +TV+EITG+L IQ+WP + + F NL I GR
Sbjct: 362 DFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGR 421
Query: 430 TKQHGQFSLAVV-SLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF-GTSGQK 487
+ + FSL ++ +LN+TSLG RSLKEIS G + IS N+ LCY +++NW K+ G + ++
Sbjct: 422 SLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEER 481
Query: 488 TKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPR 547
I NR C A G+VC LCS GCWGP P C+SCRN SRG CV CN L GEPR
Sbjct: 482 LDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPR 541
Query: 548 EFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLV 607
EF +EC CHPEC P TC G G D C QCAH+ DGPHCV +CP GV+G +
Sbjct: 542 EFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGP-I 600
Query: 608 WKYADAGHVCHLCHPNCTYGCTGPGLEGCPTN-----GPKIPSIATGMVGALLLLLVVAL 662
+KY D + C CH NCT GC GP L+ C G ++A ++ L+++ ++
Sbjct: 601 YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG 660
Query: 663 GIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGA 722
G L+ R R I KR +RR L+ E +EPL PS +A N+ L RI KETE +K+KVLGSG
Sbjct: 661 GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKA-NKVLARIFKETELRKLKVLGSGV 719
Query: 723 FGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICL 782
FGTV+KG+WIPEGE +KIPV IK + + + ++ + + D + S+D+ H+ RLLG+C
Sbjct: 720 FGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCP 779
Query: 783 TSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARN 842
S++QL+TQ +P G LLD+VR+H+ +G Q LLNW VQIAKGM YLE+ +VHR+LAARN
Sbjct: 780 GSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARN 839
Query: 843 VLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV 902
VL+K+P V++ DFG+A LL ++K+ K PIKWMALESI YTHQSDVWSYGV
Sbjct: 840 VLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGV 899
Query: 903 TVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR 962
TVWELMTFG++PY G+ +E+ +LEKGERL QP ICTIDVYM+MVKCWMID + RP F+
Sbjct: 900 TVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFK 959
Query: 963 ELIIEFSKMARDPQRYLVIQGDERMHL-PSPTDSNFYRALMDEEDMDDVVDAD 1014
EL EF++MARDP RYLVI+ + + P P ++E +++ +D D
Sbjct: 960 ELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLD 1012
>gi|41327734 epidermal growth factor receptor isoform c precursor
[Homo sapiens]
Length = 405
Score = 847 bits (2188), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
Score = 94.4 bits (233), Expect = 6e-19
Identities = 78/277 (28%), Positives = 116/277 (41%), Gaps = 53/277 (19%)
Query: 334 RKVCNGIG-----IGEFKDS-LSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPL 387
+KVC G +G F+D LS+ + F NC + G+L I V D
Sbjct: 28 KKVCQGTSNKLTQLGTFEDHFLSLQ----RMFNNCEVVLGNLEITYVQRNYD-------- 75
Query: 388 DPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVS----- 442
L LKT++E+ G++LI N + ENL+IIRG ++LAV+S
Sbjct: 76 ----LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVLSNYDAN 128
Query: 443 -LNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKA 501
+ L +R+L+EI G V S N LC +I W+ + + +SN +
Sbjct: 129 KTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSD-----FLSNMSMDFQNH 183
Query: 502 TG--QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCH 559
G Q C C CWG +C + ++C +C G+ S+C CH
Sbjct: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRC---RGK-----SPSDC--CH 233
Query: 560 PECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCP 596
+C CTG +C+ C + D C TCP
Sbjct: 234 NQCA-----AGCTGPRESDCLVCRKFRDEATCKDTCP 265
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 215 bits (548), Expect = 2e-55
Identities = 112/283 (39%), Positives = 173/283 (61%), Gaps = 6/283 (2%)
Query: 691 PLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLW-IPEGEKVKIPVAIKELRE 749
P P+GE P Q+L ++ E + + ++ LG G+FG V +G W P G+ V + V +
Sbjct: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 164
Query: 750 ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNI 809
+ P+A + + E M S+D+ ++ RL G+ LT ++++T+L P G LLD +R+H+ +
Sbjct: 165 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 224
Query: 810 GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY 869
L + VQ+A+GM YLE +R +HRDLAARN+L+ T VKI DFGL + L + Y
Sbjct: 225 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 284
Query: 870 -HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE 928
E KVP W A ES+ R ++H SD W +GVT+WE+ T+G +P+ G+ S+I ++
Sbjct: 285 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 344
Query: 929 K-GERLPQPPICTIDVYMIMVKCWMIDADSRPKF---RELIIE 967
K GERLP+P C D+Y +MV+CW + RP F R+ ++E
Sbjct: 345 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLE 387
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 215 bits (548), Expect = 2e-55
Identities = 112/283 (39%), Positives = 173/283 (61%), Gaps = 6/283 (2%)
Query: 691 PLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLW-IPEGEKVKIPVAIKELRE 749
P P+GE P Q+L ++ E + + ++ LG G+FG V +G W P G+ V + V +
Sbjct: 168 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 227
Query: 750 ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNI 809
+ P+A + + E M S+D+ ++ RL G+ LT ++++T+L P G LLD +R+H+ +
Sbjct: 228 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 287
Query: 810 GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY 869
L + VQ+A+GM YLE +R +HRDLAARN+L+ T VKI DFGL + L + Y
Sbjct: 288 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 347
Query: 870 -HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE 928
E KVP W A ES+ R ++H SD W +GVT+WE+ T+G +P+ G+ S+I ++
Sbjct: 348 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 407
Query: 929 K-GERLPQPPICTIDVYMIMVKCWMIDADSRPKF---RELIIE 967
K GERLP+P C D+Y +MV+CW + RP F R+ ++E
Sbjct: 408 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLE 450
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 209 bits (532), Expect = 1e-53
Identities = 128/364 (35%), Positives = 194/364 (53%), Gaps = 20/364 (5%)
Query: 649 GMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQE------RELVEPLTP-----SGE 697
G V ++LL+V G+G F+ RR RK R E E ++PL + E
Sbjct: 539 GGVAVGVVLLLVLAGVGFFIHRR---RKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYE 595
Query: 698 APNQALLRILKETE---FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK 754
PNQA+L+ E + KV+G+G FG VYKG+ K ++PVAIK L+ + K
Sbjct: 596 DPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK 655
Query: 755 ANKEILDEAYVMASVDNPHVCRLLGICLT-STVQLITQLMPFGCLLDYVREHKDNIGSQY 813
+ L EA +M + ++ RL G+ + +IT+ M G L ++RE
Sbjct: 656 QRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQ 715
Query: 814 LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAE-EKEYHAE 872
L+ IA GM YL + VHRDLAARN+LV + K++DFGL+++L + E Y
Sbjct: 716 LVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS 775
Query: 873 GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER 932
GGK+PI+W A E+I +R +T SDVWS+G+ +WE+MT+G +PY + E+ + G R
Sbjct: 776 GGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR 835
Query: 933 LPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG-DERMHLPS 991
LP P C +Y +M++CW + RPKF +++ K+ R P + D R+ +
Sbjct: 836 LPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRL 895
Query: 992 PTDS 995
P+ S
Sbjct: 896 PSTS 899
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 205 bits (521), Expect = 2e-52
Identities = 124/345 (35%), Positives = 194/345 (56%), Gaps = 18/345 (5%)
Query: 651 VGALLLLLVVALGIGLFM--RRRHIVRKRTLR------RLLQERELVEPLTPSGEAPNQA 702
V +LL +V+ + IG F + +H ++ L +L R V+P T E P QA
Sbjct: 551 VAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTY--EDPTQA 608
Query: 703 LLRILKETEFKKI---KVLGSGAFGTVYKG-LWIPEGEKVKIPVAIKELREATSPKANKE 758
+ KE + I KV+G+G FG V G L +P K +I VAIK L+ + K ++
Sbjct: 609 VHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPS--KKEISVAIKTLKVGYTEKQRRD 666
Query: 759 ILDEAYVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNW 817
L EA +M D+P++ RL G+ S V ++T+ M G L ++R+H L+
Sbjct: 667 FLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGM 726
Query: 818 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAE-EKEYHAEGGKV 876
IA GM YL D VHRDLAARN+L+ + K++DFGL+++L + E Y GGK+
Sbjct: 727 LRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKI 786
Query: 877 PIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQP 936
PI+W + E+I +R +T SDVWSYG+ +WE+M++G +PY + ++ +++G RLP P
Sbjct: 787 PIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPP 846
Query: 937 PICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVI 981
C +Y +M+ CW D ++RPKF +++ K+ R+P +I
Sbjct: 847 MDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKII 891
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 204 bits (518), Expect = 5e-52
Identities = 110/314 (35%), Positives = 174/314 (55%), Gaps = 8/314 (2%)
Query: 716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 775
+ +G G FG V++G+++ E + VAIK + TS ++ L EA M D+PH+
Sbjct: 448 RCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIV 506
Query: 776 RLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVH 835
+L+G+ + V +I +L G L +++ K ++ L+ + Q++ + YLE +R VH
Sbjct: 507 KLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVH 566
Query: 836 RDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS 895
RD+AARNVLV + VK+ DFGL++ + + Y A GK+PIKWMA ESI R +T S
Sbjct: 567 RDIAARNVLVSSNDCVKLGDFGLSRYM-EDSTYYKASKGKLPIKWMAPESINFRRFTSAS 625
Query: 896 DVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDA 955
DVW +GV +WE++ G KP+ G+ +++ +E GERLP PP C +Y +M KCW D
Sbjct: 626 DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDP 685
Query: 956 DSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADE 1015
RP+F EL + S + + + Q +ERM + S + ++
Sbjct: 686 SRRPRFTELKAQLSTILEEEK----AQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPG 741
Query: 1016 YLIPQ--QGFFSSP 1027
Y P+ +GF+ SP
Sbjct: 742 YPSPRSSEGFYPSP 755
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 204 bits (518), Expect = 5e-52
Identities = 110/314 (35%), Positives = 174/314 (55%), Gaps = 8/314 (2%)
Query: 716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 775
+ +G G FG V++G+++ E + VAIK + TS ++ L EA M D+PH+
Sbjct: 426 RCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIV 484
Query: 776 RLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVH 835
+L+G+ + V +I +L G L +++ K ++ L+ + Q++ + YLE +R VH
Sbjct: 485 KLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVH 544
Query: 836 RDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS 895
RD+AARNVLV + VK+ DFGL++ + + Y A GK+PIKWMA ESI R +T S
Sbjct: 545 RDIAARNVLVSSNDCVKLGDFGLSRYM-EDSTYYKASKGKLPIKWMAPESINFRRFTSAS 603
Query: 896 DVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDA 955
DVW +GV +WE++ G KP+ G+ +++ +E GERLP PP C +Y +M KCW D
Sbjct: 604 DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDP 663
Query: 956 DSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADE 1015
RP+F EL + S + + + Q +ERM + S + ++
Sbjct: 664 SRRPRFTELKAQLSTILEEEK----AQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPG 719
Query: 1016 YLIPQ--QGFFSSP 1027
Y P+ +GF+ SP
Sbjct: 720 YPSPRSSEGFYPSP 733
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 203 bits (517), Expect = 7e-52
Identities = 107/248 (43%), Positives = 161/248 (64%), Gaps = 5/248 (2%)
Query: 716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 774
K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++
Sbjct: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409
Query: 775 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 834
R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ V
Sbjct: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468
Query: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG-GKVPIKWMALESILHRIYTH 893
HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++
Sbjct: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
Query: 894 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 953
+SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW
Sbjct: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588
Query: 954 DADSRPKF 961
D ++RP F
Sbjct: 589 DVENRPGF 596
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 203 bits (517), Expect = 7e-52
Identities = 107/248 (43%), Positives = 161/248 (64%), Gaps = 5/248 (2%)
Query: 716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 774
K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++
Sbjct: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432
Query: 775 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 834
R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ V
Sbjct: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
Query: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG-GKVPIKWMALESILHRIYTH 893
HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++
Sbjct: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
Query: 894 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 953
+SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW
Sbjct: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611
Query: 954 DADSRPKF 961
D ++RP F
Sbjct: 612 DVENRPGF 619
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 202 bits (515), Expect = 1e-51
Identities = 122/352 (34%), Positives = 197/352 (55%), Gaps = 22/352 (6%)
Query: 642 KIPSIA-TGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQE----------RELVE 690
++P IA + G + ++ +VA+ I + R+R ++ LQ + ++
Sbjct: 538 QLPLIAGSAAAGVVFVVSLVAISI-VCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYID 596
Query: 691 PLTPSGEAPNQALLRILKETEFKKIK---VLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL 747
P T E PN+A+ KE + +K V+G+G FG VYKG G++ +I VAIK L
Sbjct: 597 PFTY--EDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKR-EIYVAIKTL 653
Query: 748 REATSPKANKEILDEAYVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHK 806
+ S K ++ L EA +M D+P++ RL G+ S V +IT+ M G L ++R++
Sbjct: 654 KAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQND 713
Query: 807 DNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEE 866
L+ IA GM YL + VHRDLAARN+LV + K++DFGL++ L +
Sbjct: 714 GQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDT 773
Query: 867 KE---YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI 923
+ + GGK+P++W A E+I +R +T SDVWSYG+ +WE+M+FG +PY + ++
Sbjct: 774 SDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDV 833
Query: 924 SSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP 975
+ +E+ RLP P C ++ +M+ CW D +SRP+F E++ KM R+P
Sbjct: 834 INAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNP 885
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 201 bits (512), Expect = 3e-51
Identities = 109/270 (40%), Positives = 158/270 (58%), Gaps = 9/270 (3%)
Query: 707 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 766
++ T+ LG G +G VY G+W +K + VA+K L+E T +E L EA VM
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 321
Query: 767 ASVDNPHVCRLLGIC-LTSTVQLITQLMPFGCLLDYVRE-HKDNIGSQYLLNWCVQIAKG 824
+ +P++ +LLG+C L ++T+ MP+G LLDY+RE +++ + + LL QI+
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 825 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 884
M YLE + +HRDLAARN LV VK+ DFGL++L+ + HA G K PIKW A E
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 440
Query: 885 SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY 944
S+ + ++ +SDVW++GV +WE+ T+G PY GI S++ +LEKG R+ QP C VY
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 945 MIMVKCWMIDADSRPKFRELIIEFSKMARD 974
+M CW RP F E F M D
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 201 bits (512), Expect = 3e-51
Identities = 109/270 (40%), Positives = 158/270 (58%), Gaps = 9/270 (3%)
Query: 707 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 766
++ T+ LG G +G VY G+W +K + VA+K L+E T +E L EA VM
Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 336
Query: 767 ASVDNPHVCRLLGIC-LTSTVQLITQLMPFGCLLDYVRE-HKDNIGSQYLLNWCVQIAKG 824
+ +P++ +LLG+C L ++T+ MP+G LLDY+RE +++ + + LL QI+
Sbjct: 337 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 396
Query: 825 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 884
M YLE + +HRDLAARN LV VK+ DFGL++L+ + HA G K PIKW A E
Sbjct: 397 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 455
Query: 885 SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY 944
S+ + ++ +SDVW++GV +WE+ T+G PY GI S++ +LEKG R+ QP C VY
Sbjct: 456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 515
Query: 945 MIMVKCWMIDADSRPKFRELIIEFSKMARD 974
+M CW RP F E F M D
Sbjct: 516 ELMRACWKWSPADRPSFAETHQAFETMFHD 545
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 201 bits (512), Expect = 3e-51
Identities = 109/270 (40%), Positives = 158/270 (58%), Gaps = 9/270 (3%)
Query: 707 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 766
++ T+ LG G +G VY G+W +K + VA+K L+E T +E L EA VM
Sbjct: 262 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 315
Query: 767 ASVDNPHVCRLLGIC-LTSTVQLITQLMPFGCLLDYVRE-HKDNIGSQYLLNWCVQIAKG 824
+ +P++ +LLG+C L ++T+ MP+G LLDY+RE +++ + + LL QI+
Sbjct: 316 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 375
Query: 825 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 884
M YLE + +HRDLAARN LV VK+ DFGL++L+ + HA G K PIKW A E
Sbjct: 376 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 434
Query: 885 SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY 944
S+ + ++ +SDVW++GV +WE+ T+G PY GI S++ +LEKG R+ QP C VY
Sbjct: 435 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 494
Query: 945 MIMVKCWMIDADSRPKFRELIIEFSKMARD 974
+M CW RP F E F M D
Sbjct: 495 ELMRACWKWSPADRPSFAETHQAFETMFHD 524
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 201 bits (512), Expect = 3e-51
Identities = 109/270 (40%), Positives = 158/270 (58%), Gaps = 9/270 (3%)
Query: 707 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 766
++ T+ LG G +G VY G+W +K + VA+K L+E T +E L EA VM
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 321
Query: 767 ASVDNPHVCRLLGIC-LTSTVQLITQLMPFGCLLDYVRE-HKDNIGSQYLLNWCVQIAKG 824
+ +P++ +LLG+C L ++T+ MP+G LLDY+RE +++ + + LL QI+
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 825 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 884
M YLE + +HRDLAARN LV VK+ DFGL++L+ + HA G K PIKW A E
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 440
Query: 885 SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY 944
S+ + ++ +SDVW++GV +WE+ T+G PY GI S++ +LEKG R+ QP C VY
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 945 MIMVKCWMIDADSRPKFRELIIEFSKMARD 974
+M CW RP F E F M D
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 201 bits (512), Expect = 3e-51
Identities = 109/270 (40%), Positives = 158/270 (58%), Gaps = 9/270 (3%)
Query: 707 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 766
++ T+ LG G +G VY G+W +K + VA+K L+E T +E L EA VM
Sbjct: 247 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEV--EEFLKEAAVM 300
Query: 767 ASVDNPHVCRLLGIC-LTSTVQLITQLMPFGCLLDYVRE-HKDNIGSQYLLNWCVQIAKG 824
+ +P++ +LLG+C L ++T+ MP+G LLDY+RE +++ + + LL QI+
Sbjct: 301 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 360
Query: 825 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 884
M YLE + +HRDLAARN LV VK+ DFGL++L+ + HA G K PIKW A E
Sbjct: 361 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 419
Query: 885 SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY 944
S+ + ++ +SDVW++GV +WE+ T+G PY GI S++ +LEKG R+ QP C VY
Sbjct: 420 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 479
Query: 945 MIMVKCWMIDADSRPKFRELIIEFSKMARD 974
+M CW RP F E F M D
Sbjct: 480 ELMRACWKWSPADRPSFAETHQAFETMFHD 509
>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
Length = 976
Score = 199 bits (507), Expect = 1e-50
Identities = 127/371 (34%), Positives = 189/371 (50%), Gaps = 22/371 (5%)
Query: 644 PSIATGMVGALLLLLVVALGIG-------LFMRRRHIVRKRTLRRLLQ----ERELVEPL 692
P ++ G+ G ++ ++ L +G L R R R+R R+ + +RE L
Sbjct: 537 PPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWL 596
Query: 693 TP-----SGEAPNQALLRILKETEFKKIKV---LGSGAFGTVYKGLWIPEGEKVKIPVAI 744
P + E P Q L +E + + V +G G FG VY+G + K VAI
Sbjct: 597 KPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKT-VAI 655
Query: 745 KELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLT-STVQLITQLMPFGCLLDYVR 803
K L++ + L EA +M +PH+ L G+ + +IT+ M G L ++R
Sbjct: 656 KTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLR 715
Query: 804 EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLG 863
E +D + L+ IA GMNYL + VHRDLAARN+LV K++DFGL +LL
Sbjct: 716 EREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLD 775
Query: 864 AEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI 923
+ Y +GGK+PI+W A E+I HRI+T SDVWS+G+ +WE+++FG KPY + E+
Sbjct: 776 DFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEV 835
Query: 924 SSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 983
+E G RLP P C +Y +M CW D RP F++L ++ +P I
Sbjct: 836 MKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIAN 895
Query: 984 -DERMHLPSPT 993
D RM L P+
Sbjct: 896 FDPRMTLRLPS 906
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 199 bits (506), Expect = 1e-50
Identities = 121/353 (34%), Positives = 193/353 (54%), Gaps = 25/353 (7%)
Query: 642 KIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQE--------------RE 687
+IP IA + ++LL VV IG+ + R + + +E R
Sbjct: 571 QIPVIAVSVTVGVILLAVV---IGVLLSGRRCGYSKAKQDPEEEKMHFHNGHIKLPGVRT 627
Query: 688 LVEPLTPSGEAPNQALLRILKETEFKKI---KVLGSGAFGTVYKGLWIPEGEKVKIPVAI 744
++P T E PNQA+ KE E I +V+G+G FG V G G++ ++PVAI
Sbjct: 628 YIDPHTY--EDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKR-ELPVAI 684
Query: 745 KELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVR 803
K L+ + K ++ L EA +M D+P++ L G+ S V ++T+ M G L +++
Sbjct: 685 KTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLK 744
Query: 804 EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLG 863
++ L+ I+ GM YL D VHRDLAARN+L+ + K++DFGL+++L
Sbjct: 745 KNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLE 804
Query: 864 AE-EKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE 922
+ E Y GGK+PI+W A E+I R +T SDVWSYG+ +WE++++G +PY + +
Sbjct: 805 DDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD 864
Query: 923 ISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP 975
+ +E+G RLP P C +Y +M+ CW + +SRPKF E++ K+ R+P
Sbjct: 865 VIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNP 917
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 199 bits (506), Expect = 1e-50
Identities = 114/331 (34%), Positives = 181/331 (54%), Gaps = 34/331 (10%)
Query: 716 KVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHV 774
K LG G FG V K +G VA+K L+E SP +++L E V+ V++PHV
Sbjct: 728 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHV 787
Query: 775 CRLLGICLTS-TVQLITQLMPFGCLLDYVREHKDNIGSQYL------------------- 814
+L G C + LI + +G L ++RE + +G YL
Sbjct: 788 IKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR-KVGPGYLGSGGSRNSSSLDHPDERAL 846
Query: 815 -----LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY 869
+++ QI++GM YL + +LVHRDLAARN+LV + +KI+DFGL++ + E+
Sbjct: 847 TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV 906
Query: 870 HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEK 929
G++P+KWMA+ES+ IYT QSDVWS+GV +WE++T G PY GIP + ++L+
Sbjct: 907 KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKT 966
Query: 930 GERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHL 989
G R+ +P C+ ++Y +M++CW + D RP F ++ + KM + YL +
Sbjct: 967 GHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAS----- 1021
Query: 990 PSPTDSNFYRALMDEEDMDDVVDADEYLIPQ 1020
+P+DS Y + EE+ +VD + +P+
Sbjct: 1022 -TPSDSLIYDDGLSEEE-TPLVDCNNAPLPR 1050
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 199 bits (506), Expect = 1e-50
Identities = 114/331 (34%), Positives = 181/331 (54%), Gaps = 34/331 (10%)
Query: 716 KVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHV 774
K LG G FG V K +G VA+K L+E SP +++L E V+ V++PHV
Sbjct: 728 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHV 787
Query: 775 CRLLGICLTS-TVQLITQLMPFGCLLDYVREHKDNIGSQYL------------------- 814
+L G C + LI + +G L ++RE + +G YL
Sbjct: 788 IKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR-KVGPGYLGSGGSRNSSSLDHPDERAL 846
Query: 815 -----LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY 869
+++ QI++GM YL + +LVHRDLAARN+LV + +KI+DFGL++ + E+
Sbjct: 847 TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV 906
Query: 870 HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEK 929
G++P+KWMA+ES+ IYT QSDVWS+GV +WE++T G PY GIP + ++L+
Sbjct: 907 KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKT 966
Query: 930 GERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHL 989
G R+ +P C+ ++Y +M++CW + D RP F ++ + KM + YL +
Sbjct: 967 GHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAS----- 1021
Query: 990 PSPTDSNFYRALMDEEDMDDVVDADEYLIPQ 1020
+P+DS Y + EE+ +VD + +P+
Sbjct: 1022 -TPSDSLIYDDGLSEEE-TPLVDCNNAPLPR 1050
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 198 bits (503), Expect = 3e-50
Identities = 97/255 (38%), Positives = 161/255 (63%), Gaps = 4/255 (1%)
Query: 716 KVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHV 774
++LG G FG VY+G++ +GEK+ VA+K ++ + ++ + EA +M ++D+PH+
Sbjct: 429 RILGEGFFGEVYEGVYTNHKGEKIN--VAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
Query: 775 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 834
+L+GI +I +L P+G L Y+ +K+++ L+ + +QI K M YLE V
Sbjct: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
Query: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQ 894
HRD+A RN+LV +P+ VK+ DFGL++ + +E Y A ++PIKWM+ ESI R +T
Sbjct: 547 HRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVTRLPIKWMSPESINFRRFTTA 605
Query: 895 SDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMID 954
SDVW + V +WE+++FG +P+ + ++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
Query: 955 ADSRPKFRELIIEFS 969
RP+F EL+ S
Sbjct: 666 PSDRPRFTELVCSLS 680
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 198 bits (503), Expect = 3e-50
Identities = 97/255 (38%), Positives = 161/255 (63%), Gaps = 4/255 (1%)
Query: 716 KVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHV 774
++LG G FG VY+G++ +GEK+ VA+K ++ + ++ + EA +M ++D+PH+
Sbjct: 429 RILGEGFFGEVYEGVYTNHKGEKIN--VAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
Query: 775 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 834
+L+GI +I +L P+G L Y+ +K+++ L+ + +QI K M YLE V
Sbjct: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
Query: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQ 894
HRD+A RN+LV +P+ VK+ DFGL++ + +E Y A ++PIKWM+ ESI R +T
Sbjct: 547 HRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVTRLPIKWMSPESINFRRFTTA 605
Query: 895 SDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMID 954
SDVW + V +WE+++FG +P+ + ++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
Query: 955 ADSRPKFRELIIEFS 969
RP+F EL+ S
Sbjct: 666 PSDRPRFTELVCSLS 680
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 198 bits (503), Expect = 3e-50
Identities = 97/255 (38%), Positives = 161/255 (63%), Gaps = 4/255 (1%)
Query: 716 KVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHV 774
++LG G FG VY+G++ +GEK+ VA+K ++ + ++ + EA +M ++D+PH+
Sbjct: 429 RILGEGFFGEVYEGVYTNHKGEKIN--VAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486
Query: 775 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 834
+L+GI +I +L P+G L Y+ +K+++ L+ + +QI K M YLE V
Sbjct: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546
Query: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQ 894
HRD+A RN+LV +P+ VK+ DFGL++ + +E Y A ++PIKWM+ ESI R +T
Sbjct: 547 HRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVTRLPIKWMSPESINFRRFTTA 605
Query: 895 SDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMID 954
SDVW + V +WE+++FG +P+ + ++ +LEKG+RLP+P +C +Y +M +CW D
Sbjct: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665
Query: 955 ADSRPKFRELIIEFS 969
RP+F EL+ S
Sbjct: 666 PSDRPRFTELVCSLS 680
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,846,741
Number of Sequences: 37866
Number of extensions: 2677620
Number of successful extensions: 8878
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 558
Number of HSP's successfully gapped in prelim test: 324
Number of HSP's that attempted gapping in prelim test: 6530
Number of HSP's gapped (non-prelim): 1404
length of query: 1210
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1096
effective length of database: 13,930,794
effective search space: 15268150224
effective search space used: 15268150224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.