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Search of human proteins with 122937249
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
(1141 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 2298 0.0
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 1138 0.0
gi|112382257 InaD-like [Homo sapiens] 107 8e-23
gi|148746189 multiple PDZ domain protein [Homo sapiens] 105 2e-22
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 95 3e-19
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 95 4e-19
gi|45827729 scribble isoform b [Homo sapiens] 90 1e-17
gi|45827731 scribble isoform a [Homo sapiens] 90 1e-17
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 87 7e-17
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 87 7e-17
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 86 2e-16
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 86 2e-16
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 86 2e-16
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 84 6e-16
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 84 6e-16
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 83 1e-15
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 80 1e-14
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 80 1e-14
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 79 2e-14
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 78 5e-14
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 78 5e-14
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 78 5e-14
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 77 7e-14
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 77 7e-14
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 73 2e-12
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 73 2e-12
gi|87196343 PDZ domain containing 2 [Homo sapiens] 73 2e-12
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 72 2e-12
gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens] 72 2e-12
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 70 1e-11
>gi|122937249 glutamate receptor interacting protein 2 [Homo sapiens]
Length = 1141
Score = 2298 bits (5955), Expect = 0.0
Identities = 1141/1141 (100%), Positives = 1141/1141 (100%)
Query: 1 MRLSSLTEEAVDGGNGGEWGEDLLEQFTCIPSRVVEAKTAPEWPLCPGEGQGLHGEPLPD 60
MRLSSLTEEAVDGGNGGEWGEDLLEQFTCIPSRVVEAKTAPEWPLCPGEGQGLHGEPLPD
Sbjct: 1 MRLSSLTEEAVDGGNGGEWGEDLLEQFTCIPSRVVEAKTAPEWPLCPGEGQGLHGEPLPD 60
Query: 61 HCQGTGGQIDPSLGRGGRAKQRGSRGSWWAAGETIANMLCGLSRETPGEADDGPYSKGGK 120
HCQGTGGQIDPSLGRGGRAKQRGSRGSWWAAGETIANMLCGLSRETPGEADDGPYSKGGK
Sbjct: 61 HCQGTGGQIDPSLGRGGRAKQRGSRGSWWAAGETIANMLCGLSRETPGEADDGPYSKGGK 120
Query: 121 DAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGL 180
DAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGL
Sbjct: 121 DAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGL 180
Query: 181 AARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRII 240
AARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRII
Sbjct: 181 AARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRII 240
Query: 241 SKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVD 300
SKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVD
Sbjct: 241 SKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVD 300
Query: 301 GIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISL 360
GIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISL
Sbjct: 301 GIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISL 360
Query: 361 TTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEK 420
TTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEK
Sbjct: 361 TTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEK 420
Query: 421 VRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQD 480
VRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQD
Sbjct: 421 VRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQD 480
Query: 481 QSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASST 540
QSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASST
Sbjct: 481 QSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASST 540
Query: 541 VGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLL 600
VGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLL
Sbjct: 541 VGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLL 600
Query: 601 QVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPK 660
QVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPK
Sbjct: 601 QVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPK 660
Query: 661 KRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDA 720
KRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDA
Sbjct: 661 KRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDA 720
Query: 721 VQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVI 780
VQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVI
Sbjct: 721 VQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVI 780
Query: 781 SGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPL 840
SGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPL
Sbjct: 781 SGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPL 840
Query: 841 LPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVESWDSSATEGGFGGPGSY 900
LPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVESWDSSATEGGFGGPGSY
Sbjct: 841 LPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVESWDSSATEGGFGGPGSY 900
Query: 901 TPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEEEEDDWEPPTSPAPG 960
TPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEEEEDDWEPPTSPAPG
Sbjct: 901 TPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEEEEDDWEPPTSPAPG 960
Query: 961 PAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGTVQRVALEGRPGHRPWQRGREVR 1020
PAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGTVQRVALEGRPGHRPWQRGREVR
Sbjct: 961 PAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGTVQRVALEGRPGHRPWQRGREVR 1020
Query: 1021 ASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGGL 1080
ASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGGL
Sbjct: 1021 ASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGGL 1080
Query: 1081 QPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSPGPSSPRM 1140
QPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSPGPSSPRM
Sbjct: 1081 QPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSPGPSSPRM 1140
Query: 1141 L 1141
L
Sbjct: 1141 L 1141
>gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens]
Length = 1076
Score = 1138 bits (2943), Expect = 0.0
Identities = 623/1077 (57%), Positives = 766/1077 (71%), Gaps = 115/1077 (10%)
Query: 111 DDGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKP 170
D+ PY+K D +LA RRQSIPEEF+G TVVEL+KKEG+TLGLT+SGG DKDGKP
Sbjct: 19 DESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP 78
Query: 171 RVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPP 230
RVSNLR GG+AARSD L++GDYI++VNGI+L + RHDEII+LLKNVGERVVLEVEYELPP
Sbjct: 79 RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPP 138
Query: 231 PAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSL 290
+ + + +I +TV+V+L+KEGN+FGFV+RGGAH+D +KSRP+V+T VRPGGPADREG++
Sbjct: 139 VSVQGSS-VIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTI 197
Query: 291 KVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVK 350
K GDRLLSVDGI L G +HA A++ L+QC EA +EYDV+ D+VA ASGPL+VE+ K
Sbjct: 198 KPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAK 257
Query: 351 TPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEA 410
TPG++LG++LTT+ NK VI ID+IK AS+ DR GALH GDHILSIDGTSME+C+L EA
Sbjct: 258 TPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEA 317
Query: 411 TKLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRM 470
T+ LA+ +++V+LEILP Q++ L+
Sbjct: 318 TQFLANTTDQVKLEILPHHQTRLALK---------------------------------- 343
Query: 471 PTWATPAGQDQSRSLSSTPFSSPTLNHAFSCN--NPSTLPRGSQPMSPRTTMGRRRQRRR 528
G D + +SS+ SPT A+S + N TLPR SPR TM RRR +++
Sbjct: 344 -------GPDHAALVSSS--FSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKK 394
Query: 529 EHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFI 588
+ KSSLSLASSTVG GQ+VHTETTEVVL DP++GFG+QLQG +FATETLSSPPL+ +I
Sbjct: 395 DFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYI 454
Query: 589 EPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVI 648
E DSPAERCG+LQ+GDRV++INGI TED T EEA+QLLRD+++ KV LE+EFDVAESVI
Sbjct: 455 EADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVI 514
Query: 649 PSSGTFHVKLPKKRSVELGITISS-ASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAI 707
PSSGTFHVKLPKK +VELGITISS +SRK G+PL+ISDIKKGSVAHRTGTLE GDKLLAI
Sbjct: 515 PSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAI 574
Query: 708 DNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGIT 767
DNIRLDNC MEDAVQIL+QCEDLVKLKIRKDEDNSDE E++GA+ YTVELKRYGGPLGIT
Sbjct: 575 DNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGIT 634
Query: 768 ISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGET 827
ISGTEEPFDPI+IS LTK GLAERTGAIH+GDRILAIN+ SLKG+PLSEAIHLLQ+AGET
Sbjct: 635 ISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGET 694
Query: 828 VTLKIKKQLDRPLL--PRK---SGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAV 882
VTLKIKKQ D P+K S LS+ D +ED + A K G + + VPSVDSAV
Sbjct: 695 VTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAV 754
Query: 883 ESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESF 942
+SWD SA + +G G+ + T R P P T+PR +Y
Sbjct: 755 DSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSY-- 812
Query: 943 PEEEEEDDWEPPTSPAPGPA-------REEGFWRMFGEALEDLESCGQSELLRELE---- 991
+DW+ T+ A +EE FW +ALEDLE+CGQS +LRELE
Sbjct: 813 ------EDWDRSTASGFAGAADSAETEQEENFW---SQALEDLETCGQSGILRELEEKAD 863
Query: 992 -----------ASIMTGTV---------------QRVALEGRPGHRPWQR---------- 1015
A+IM+G+ ++ + + R RP
Sbjct: 864 RRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPS 923
Query: 1016 --GRE---VRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVR 1070
GR+ +R E++E++ PTP+E+HKVTL+KD DFGFSV+DGLLEKGVYV +R
Sbjct: 924 DVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIR 983
Query: 1071 PDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSS 1127
P GP GGL+P+DR+LQVNHVRTRDFDCCL VPL+AE+G+ L+L+ISR P + S
Sbjct: 984 PAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKS 1040
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 107 bits (266), Expect = 8e-23
Identities = 160/750 (21%), Positives = 286/750 (38%), Gaps = 121/750 (16%)
Query: 145 VVELIKKEGSTLGLTISGGTD-----KDGKPR----VSNLRPGGLAARSDLLNIGDYIRS 195
+VE+ ++ +LG++I GG K+G+ + + A +++ L GD I
Sbjct: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
Query: 196 VNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSF 255
V+G+ L H E + +KN G VV V+ + + PR+I +++ + N
Sbjct: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFIVQ------SLSSTPRVIP-----NVHNKANK- 1175
Query: 256 GFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALAT 315
+ G ++D + + + G A L + L+ D
Sbjct: 1176 ---ITGNQNQDTQEKKE------KRQGTAPPPMKLPPPYKALTDDS-------------- 1212
Query: 316 LRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDR 375
+ E F D A+ G L + ++ + LG+SL R++ I +
Sbjct: 1213 -DENEEEDAFT---DQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVG 1268
Query: 376 IKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPL 435
I P G + GD +L I+ + S A+ ++ + KV+L + + +
Sbjct: 1269 INPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQM 1328
Query: 436 RPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTL 495
V + P S G + P + ++S
Sbjct: 1329 AVTPFPVPSSSPSSIEDQSGTEP-ISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPT 1387
Query: 496 NHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEV 555
+FS P S + G + S+ A+ + PG +++
Sbjct: 1388 KVSFSSQEIPLAPASSYHSTDADFTG---YGGFQAPLSVDPATCPIVPGQEMI------- 1437
Query: 556 VLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATE 615
+ SG GL + GG +T + ++ + + A R G L GD++L +NG+
Sbjct: 1438 IEISKGRSGLGLSIVGG---KDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLR 1494
Query: 616 DGTMEEANQLLRDAALAHKVVL---EVEFDVAESVIPSSGTFHVKLPKKRSVELGITISS 672
+ + EEA LR ++V+ E + E++ F V L KK LG++I
Sbjct: 1495 NSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENL----EIFPVDLQKKAGRGLGLSI-- 1548
Query: 673 ASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVK 732
++ G + ISDI KG A G L GD++L+++ + N E IL+ + LV+
Sbjct: 1549 VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQ 1608
Query: 733 LKI----------------------------------------------RKDEDNSDELE 746
L+I ++ D S +
Sbjct: 1609 LEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNS 1668
Query: 747 TTGAVSYTVELKR-YGGPLGITISGTE-EPFD--PIVISGLTKRGLAERTGAIHVGDRIL 802
T TVE+ R LGI+I+G P P+ I+ + G+A RT + VGDRI+
Sbjct: 1669 GTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIV 1728
Query: 803 AINNVSLKGRPLSEAIHLLQVAGETVTLKI 832
+IN L G ++ ++LL+ A + L++
Sbjct: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQV 1758
Score = 81.3 bits (199), Expect = 5e-15
Identities = 76/306 (24%), Positives = 128/306 (41%), Gaps = 46/306 (15%)
Query: 172 VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTR-LRHDEIITLLKNVGERVVLEVEYE--- 227
V +++PG +A R L D I ++N L + + H + I LL+ + L V E
Sbjct: 164 VKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVH 223
Query: 228 -LPPPAPENNPRIISKTV------DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRP 280
+ N + +TV +V L +G+ GF + GG K+ +V+ + P
Sbjct: 224 TKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGG------KTSGVVVRTIVP 277
Query: 281 GGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYD---------- 330
GG ADR+G L+ GD +L + G + G + LR C + V D
Sbjct: 278 GGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPP 337
Query: 331 ------VATPDTVANASG-------PLMVEIVKTPGSALGISLT----TTSLRNKSVITI 373
VA P + G VE+V+ G +LGI + T+ S I +
Sbjct: 338 APAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYV 397
Query: 374 DRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEIL--PVPQS 431
I P S +G + D I+++DG +++ + + ++L + + V L ++ S
Sbjct: 398 KSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457
Query: 432 QRPLRP 437
PL P
Sbjct: 458 TSPLEP 463
Score = 74.7 bits (182), Expect = 5e-13
Identities = 101/426 (23%), Positives = 153/426 (35%), Gaps = 93/426 (21%)
Query: 233 PENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPL---VLTYVRPGGPADREGS 289
P P + + + + + K + G + GG K PL V+ V G A R+G
Sbjct: 1425 PATCPIVPGQEMIIEISKGRSGLGLSIVGG------KDTPLNAIVIHEVYEEGAAARDGR 1478
Query: 290 LKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIV 349
L GD++L V+G+ L +SH A+ LRQ + V D A N V++
Sbjct: 1479 LWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLE-IFPVDLQ 1537
Query: 350 KTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLE 409
K G LG+S+ RN S + I I D G L GD ILS++G M + S
Sbjct: 1538 KKAGRGLGLSI--VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQET 1595
Query: 410 ATKLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCR 469
+L V+LEI G R
Sbjct: 1596 VATILKCAQGLVQLEI----------------------------------------GRLR 1615
Query: 470 MPTWAT-------PAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGR 522
+W + G QS S P +P + + + SQ S R
Sbjct: 1616 AGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPR 1675
Query: 523 RRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSP 582
+ RE +L ++ + GG+ G PL P
Sbjct: 1676 TVEINRELSDALGISIA----GGR------------GSPLGDI----------------P 1703
Query: 583 PLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFD 642
+ I+ A R L+VGDR++SING + + + LL++A +++L+V D
Sbjct: 1704 VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA--YGRIILQVVAD 1761
Query: 643 VAESVI 648
S I
Sbjct: 1762 TNISAI 1767
Score = 68.2 bits (165), Expect = 4e-11
Identities = 59/227 (25%), Positives = 98/227 (43%), Gaps = 38/227 (16%)
Query: 549 HTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLS 608
H E E++ G SG G + GG +S +V I P A+R G LQ GD +L
Sbjct: 245 HVEEVELINDG---SGLGFGIVGG------KTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 609 INGIATEDGTMEEANQLLRDAALAHKVVL--------------EVEFDVAESVIPSSG-- 652
I G + T E+ Q+LR+ + ++++ VA + S G
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPG 355
Query: 653 -------TFHVKLPKKRSVELGITI----SSASRKRGEPLIISDIKKGSVAHRTGTLEPG 701
T++V+L +K LGI I ++ + + I GS A+ G ++
Sbjct: 356 SDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
Query: 702 DKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKI--RKDEDNSDELE 746
DK++A+D + + D V++LR +V L + RK ++ LE
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLE 462
Score = 63.9 bits (154), Expect = 8e-10
Identities = 79/345 (22%), Positives = 139/345 (40%), Gaps = 52/345 (15%)
Query: 588 IEPDSPAERCGLLQVGDRVLSINGIATEDG-TMEEANQLLRDAALAHKVVLEVEFDVAES 646
++P S A+R L+ D++L+IN + + ++A LL+ + ++++ E V
Sbjct: 167 VQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVARE-PVHTK 225
Query: 647 VIPSSGTFHVKLPKK------RSVEL-----GITISSASRKRGEPLIISDIKKGSVAHRT 695
SS LP+ VEL G+ K +++ I G +A R
Sbjct: 226 SSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSG-VVVRTIVPGGLADRD 284
Query: 696 GTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDEL---------- 745
G L+ GD +L I + E Q+LR C + V++ + +D +
Sbjct: 285 GRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPV 344
Query: 746 ------------ETTGAVSYTVELKRYGG-PLGITISG------TEEPFDPIVISGLTKR 786
+++ +Y VEL R G LGI I G T E I + +
Sbjct: 345 ALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA-SGIYVKSIIPG 403
Query: 787 GLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRKSG 846
A G I V D+I+A++ V+++G + + +L+ AG+ V L L+ RK+
Sbjct: 404 SAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL--------TLVRRKTS 455
Query: 847 SLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVESWDSSATE 891
S + + D ++ P A F ++ V+ D E
Sbjct: 456 SSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKE 500
Score = 60.5 bits (145), Expect = 9e-09
Identities = 68/257 (26%), Positives = 108/257 (42%), Gaps = 48/257 (18%)
Query: 649 PSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAID 708
PS+G + RS LG + + D++ GSVA R L+ D++LAI+
Sbjct: 140 PSTGGLGFSVVALRSQNLGKV----------DIFVKDVQPGSVADRDQRLKENDQILAIN 189
Query: 709 NIRLD-NCPMEDAVQILRQCEDLVKLKIRKD-----EDNSDELETT--------GAVSYT 754
+ LD N + A+ +L+Q ++L + ++ S L T G V
Sbjct: 190 HTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVE-E 248
Query: 755 VELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPL 814
VEL G LG I G + +V+ + GLA+R G + GD IL I +++G
Sbjct: 249 VELINDGSGLGFGIVGGKT--SGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTS 306
Query: 815 SEAIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPA 874
+ +L+ G +V + + + +G +S T A PAA A
Sbjct: 307 EQVAQVLRNCGNSVRMLVARD--------PAGDISVTPPA------------PAA-LPVA 345
Query: 875 VPSVDSAVESWDSSATE 891
+P+V S DSS E
Sbjct: 346 LPTVASKGPGSDSSLFE 362
Score = 60.1 bits (144), Expect = 1e-08
Identities = 52/202 (25%), Positives = 84/202 (41%), Gaps = 40/202 (19%)
Query: 657 KLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCP 716
KL ++ LG+ + S IS I G G L+P D+LL ++ ++L
Sbjct: 561 KLLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKS 616
Query: 717 MEDAVQILRQ---------CEDLV-----------------------KLKIRKDEDNSDE 744
+AV L++ C L + + +ED+ E
Sbjct: 617 RREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGE 676
Query: 745 LETTGAVSYTVELKRYGGPLGITISGTEEPFDP----IVISGLTKRGLAERTGAIHVGDR 800
L VEL + LG +I ++P DP IVI L G+AER+G + GDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 801 ILAINNVSLKGRPLSEAIHLLQ 822
++++N L L+EA+ +L+
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILK 758
Score = 53.9 bits (128), Expect = 8e-07
Identities = 62/244 (25%), Positives = 97/244 (39%), Gaps = 59/244 (24%)
Query: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVN 197
EE I V+L KK G LGL+I G + G +S++ GG A L GD I SVN
Sbjct: 1526 EENLEIFPVDLQKKAGRGLGLSIVGKRNGSGV-FISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 198 GIHLTRLRHDEIITLLKNVGERVVLEV--------------------------------- 224
G + + + T+LK V LE+
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSF 1644
Query: 225 ------------EYELPPPAPENNPRIIS-KTVDVSLYKEGNSFGFVLRGGAHEDGHKSR 271
+ P+ +N+ + +TV+++ + ++ G + GG +
Sbjct: 1645 APVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEIN-RELSDALGISIAGG------RGS 1697
Query: 272 PL-----VLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQ 326
PL + ++ G A R LKVGDR++S++G PL G SHA + L+ + Q
Sbjct: 1698 PLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQ 1757
Query: 327 VEYD 330
V D
Sbjct: 1758 VVAD 1761
Score = 53.9 bits (128), Expect = 8e-07
Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 13/147 (8%)
Query: 86 GSWWAAGETIANMLCGLSRETPGEADDGPYSKGGKDAGGADVSLACRRQSIPEEFRGIT- 144
GSW +A T N S+ + A + G + +R S P + T
Sbjct: 1617 GSWTSARTTSQN-----SQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTD 1671
Query: 145 ----VVELIKKEGSTLGLTISGGTDK---DGKPRVSNLRPGGLAARSDLLNIGDYIRSVN 197
VE+ ++ LG++I+GG D ++ ++ G+AAR+ L +GD I S+N
Sbjct: 1672 MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSIN 1731
Query: 198 GIHLTRLRHDEIITLLKNVGERVVLEV 224
G L L H +++ LLKN R++L+V
Sbjct: 1732 GQPLDGLSHADVVNLLKNAYGRIILQV 1758
Score = 53.5 bits (127), Expect = 1e-06
Identities = 49/187 (26%), Positives = 82/187 (43%), Gaps = 39/187 (20%)
Query: 266 DGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSH---- 321
DGH ++ + GGP D G L+ D LL V+G+ L+G S A++ L++
Sbjct: 578 DGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTL 633
Query: 322 ---EALFQVEYDVATP------------------DTVANASGPLM-----VEIVKTPGSA 355
LF E V P +T + G L V+IV+
Sbjct: 634 VCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDC 693
Query: 356 LGISLTTTSLRN-----KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEA 410
G+ + ++ +SVI I + V +RSG L PGD ++S++ +++ SL EA
Sbjct: 694 KGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEA 753
Query: 411 TKLLASI 417
++L ++
Sbjct: 754 VEILKAV 760
Score = 52.8 bits (125), Expect = 2e-06
Identities = 78/315 (24%), Positives = 125/315 (39%), Gaps = 36/315 (11%)
Query: 126 DVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPR-VSNLRPGGLAARS 184
D + R +P E ++EL +K+ + LGL+++G D+ V + P G AA
Sbjct: 1223 DQKIRQRYADLPGELH---IIEL-EKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAAD 1278
Query: 185 DLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLE-VEYE--------LPPPAPEN 235
+ IGD + +N L H ++K +V L + E P P P +
Sbjct: 1279 GRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSS 1338
Query: 236 NPRII---SKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKV 292
+P I S T +S ++G+ V G +S L ++ ++ ++ KV
Sbjct: 1339 SPSSIEDQSGTEPISSEEDGS----VEVGIKQLPESESFKLAVSQMK-----QQKYPTKV 1389
Query: 293 GDRLLSVDGIPLHGAS--HATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVK 350
S IPL AS H+T +A V+ P T G M+ +
Sbjct: 1390 S---FSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVD-----PATCPIVPGQEMIIEIS 1441
Query: 351 TPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEA 410
S LG+S+ + I I + R G L GD IL ++G + + S EA
Sbjct: 1442 KGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEA 1501
Query: 411 TKLLASISEKVRLEI 425
L +KVRL +
Sbjct: 1502 ITALRQTPQKVRLVV 1516
Score = 45.8 bits (107), Expect = 2e-04
Identities = 25/82 (30%), Positives = 48/82 (58%), Gaps = 5/82 (6%)
Query: 146 VELIKKEGSTLGLTISG--GTDKDGKPR---VSNLRPGGLAARSDLLNIGDYIRSVNGIH 200
VEL++K+G +LG+ I G GT G+ V ++ PG A + + + D I +V+G++
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 201 LTRLRHDEIITLLKNVGERVVL 222
+ + +++ +L+N G+ V L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHL 447
Score = 44.3 bits (103), Expect = 7e-04
Identities = 52/192 (27%), Positives = 82/192 (42%), Gaps = 42/192 (21%)
Query: 593 PAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVL-------EVEFDV-- 643
P + GLLQ D +L +NG+ + EA L++ +V E D
Sbjct: 591 PVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPR 650
Query: 644 -AESVIPSSGTFH---------------VKLPKKRSVEL-----GITISSASRKRGEPL- 681
E+ +P + H + P+ + VEL G+ S + +PL
Sbjct: 651 RTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQ--DPLD 708
Query: 682 ------IISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQC-EDLVKLK 734
+I + VA R+G L PGD+L++++ LDN + +AV+IL+ LV L
Sbjct: 709 PTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLG 768
Query: 735 IRKD--EDNSDE 744
I K EDN +E
Sbjct: 769 ICKPLVEDNEEE 780
Score = 37.4 bits (85), Expect = 0.082
Identities = 44/181 (24%), Positives = 66/181 (36%), Gaps = 30/181 (16%)
Query: 167 DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVL---- 222
DG +S++ GG LL D + VNG+ L E ++ LK V L
Sbjct: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
Query: 223 -------------EVEYELPPPAPENNPRIISKTVD-------------VSLYKEGNSFG 256
E LP ++N + ++ D V L K+ G
Sbjct: 638 RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLG 697
Query: 257 FVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATL 316
F + +V+ + G A+R G L GDRL+SV+ L S A A+ L
Sbjct: 698 FSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEIL 757
Query: 317 R 317
+
Sbjct: 758 K 758
Score = 35.4 bits (80), Expect = 0.31
Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 343 PLMVEIVKTPGSALGISLT---TTSLRNKS-----VITIDRIKPASVVDRSGALHPGDHI 394
P +VEI + P +LGIS+ T R K+ I I ++ S ++ AL GD I
Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 395 LSIDGTSMEHCSLLEATKLLASISEKV 421
L + G +++ S EA + + + V
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPV 1152
Score = 35.4 bits (80), Expect = 0.31
Identities = 34/145 (23%), Positives = 62/145 (42%), Gaps = 16/145 (11%)
Query: 764 LGITISGTE---------EPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPL 814
LGI+I G + E I I + + A +T A+ GD+IL ++ V L+
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
Query: 815 SEAIHLLQVAGETVTLKIKKQLDRP-LLP---RKSGSLSETSDAD-EDPADALKGGLPAA 869
SEA+ ++ AG V ++ P ++P K+ ++ + D ++ + +G P
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
Query: 870 RFSPAVPSVDSAVESWDSSATEGGF 894
P P + + D + E F
Sbjct: 1199 MKLP--PPYKALTDDSDENEEEDAF 1221
Score = 35.0 bits (79), Expect = 0.41
Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 3/72 (4%)
Query: 1063 GVYVHTVRPDGPA-HRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKP 1121
G+YV ++ P A H G +Q D+++ V+ V + F V +L AG V+ L + R+
Sbjct: 394 GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR- 452
Query: 1122 HTAHSSRAPRSP 1133
SS +P P
Sbjct: 453 -KTSSSTSPLEP 463
Score = 33.5 bits (75), Expect = 1.2
Identities = 25/87 (28%), Positives = 42/87 (48%), Gaps = 3/87 (3%)
Query: 346 VEIVKTPGSALGISLTTTSLRN--KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSM- 402
++I + LG S+ +N K I + ++P SV DR L D IL+I+ T +
Sbjct: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
Query: 403 EHCSLLEATKLLASISEKVRLEILPVP 429
++ S +A LL + +RL + P
Sbjct: 195 QNISHQQAIALLQQTTGSLRLIVAREP 221
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 105 bits (262), Expect = 2e-22
Identities = 147/623 (23%), Positives = 246/623 (39%), Gaps = 130/623 (20%)
Query: 267 GHKSRPLVLTYV---RPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLR------ 317
G+K R + ++ P G A ++G L++ D LL ++G L+G SH A + ++
Sbjct: 1366 GNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKV 1425
Query: 318 ---------------QCSHEALF------------QVEYDVATPDTVANASGPLMVEIVK 350
C A+ + E V T D + S V+ ++
Sbjct: 1426 KIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLE 1485
Query: 351 TPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEA 410
P G+ + + S + I + V G L GD IL++D + + +
Sbjct: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545
Query: 411 TKLLASISEKVRLEIL---PVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGH 467
LL + V+L I P Q+ K S+ L VP SP P
Sbjct: 1546 ISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL-----MVPQSGSPEPES 1600
Query: 468 CRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRR 527
R + S SSTP A ++P+T P
Sbjct: 1601 IR------------NTSRSSTP--------AIFASDPATCP------------------- 1621
Query: 528 REHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCF 587
+ PG ETT + G +G GL + GG ++TL ++
Sbjct: 1622 -------------IIPG-----CETTIEISKGR--TGLGLSIVGG---SDTLLGAIIIHE 1658
Query: 588 IEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVL-EVEFDVAES 646
+ + A + G L GD++L +NGI T +EA +LR ++ L E E
Sbjct: 1659 VYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEE 1718
Query: 647 VIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLA 706
+ T ++L KK LG++I ++ + +SDI KG +A G L GD++L
Sbjct: 1719 EV--CDTLTIELQKKPGKGLGLSI--VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILM 1774
Query: 707 IDNIRLDNCPMEDAVQILRQCEDLVKLKI--RKDEDNSDELETTGAVS---------YTV 755
++ + N E +L+ E + S+ LE++ + TV
Sbjct: 1775 VNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTV 1834
Query: 756 ELKRYGGP---LGITIS-GTEEPFD--PIVISGLTKRGLAERTGAIHVGDRILAINNVSL 809
E+K+ GP LGI+I+ G P PI I+ + G+A +T + VGDRI+ I S
Sbjct: 1835 EMKK--GPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTST 1892
Query: 810 KGRPLSEAIHLLQVAGETVTLKI 832
+G ++A++LL+ A ++ +++
Sbjct: 1893 EGMTHTQAVNLLKNASGSIEMQV 1915
Score = 102 bits (254), Expect = 2e-21
Identities = 170/770 (22%), Positives = 290/770 (37%), Gaps = 156/770 (20%)
Query: 141 RGITVVELIKKEGSTLGLTISGGTDKDGKPR---VSNLRPGGLAARSDLLNIGDYIRSVN 197
R + V EL+K LG ++ G ++ V ++ G +A R L D I ++N
Sbjct: 133 RHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAIN 192
Query: 198 GIHLTR-LRHDEIITLLKNVGERVVLEVEY----ELPPPAPENNPRIISKTV-------- 244
G L + + H + I++L+ + V L + +L P +P S
Sbjct: 193 GQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHW 252
Query: 245 ----DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVD 300
+ L +G+ GF + GG K+ +++ + PGG AD+ G L GD +L +
Sbjct: 253 QHMETIELVNDGSGLGFGIIGG------KATGVIVKTILPGGVADQHGRLCSGDHILKIG 306
Query: 301 GIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLM--------------- 345
L G S LRQC + + T A G +
Sbjct: 307 DTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDAS 366
Query: 346 -----------VEIVKTPGSALGISLTTTSLRNK---SVITIDRIKPASVVDRSGALHPG 391
VE+ K LGI++ K S I + I +S V+ G + G
Sbjct: 367 TQKGEESETFDVELTKNV-QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIG 425
Query: 392 DHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLH 451
D I+++DGT+++ + +A ++L + V L ++ R+ +K Q +E +
Sbjct: 426 DQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLM------------RRGMK-QEAELMS 472
Query: 452 RWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGS 511
R D + SP A + F S T N N T G
Sbjct: 473 REDVTKDADLSP-----------VNASIIKENYEKDEDFLSSTRN----TNILPTEEEGY 517
Query: 512 QPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQG 571
+S + +++ + L+ +G +IV ++ SG G+ L+
Sbjct: 518 PLLSAE--IEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKF----SENSGLGISLEA 571
Query: 572 GIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAAL 631
+ + + P+ P G L GD +L +NGI ++ +L++ +
Sbjct: 572 TV-------GHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI 624
Query: 632 AHKVVL--EVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKG 689
+V +S + S ++L +K V+LG I S+
Sbjct: 625 EVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSS---------------- 668
Query: 690 SVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTG 749
E D +LA M DA Q E+ L
Sbjct: 669 ---------ETEDPVLA----------MTDAGQ--------------STEEVQAPLAMWE 695
Query: 750 AVSYTVELKRYGGPLGITISGTEEPFDP----IVISGLTKRGLAERTGAIHVGDRILAIN 805
A +EL++ LG +I ++P DP I+I L G+AE+ G + GDR++ +N
Sbjct: 696 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 806 NVSLKGRPLSEAIHLLQVA-GETVTLKIKKQLDRPLLPRKSGSLSETSDA 854
+V+L+ L EA+ L+ A TV + + K L PL P + G +S D+
Sbjct: 756 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPL--PLSP-EEGYVSAKEDS 802
Score = 90.5 bits (223), Expect = 8e-18
Identities = 85/300 (28%), Positives = 138/300 (46%), Gaps = 28/300 (9%)
Query: 144 TVVELIKKEGSTLGLTISGGTDKD-GKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLT 202
T +E I K + LGL+I GG+D G + + G A + L GD I VNGI L
Sbjct: 1628 TTIE-ISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLR 1686
Query: 203 RLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKE-GNSFGFVLRG 261
+ HDE I +L+ +RV L + + P E + T+ + L K+ G G + G
Sbjct: 1687 KATHDEAINVLRQTPQRVRLTLYRDEAPYKEEE----VCDTLTIELQKKPGKGLGLSIVG 1742
Query: 262 GAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSH 321
++ G + ++ + GG AD +G L GD++L V+G + A+ A+A L + S
Sbjct: 1743 KRNDTG-----VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQ-EAVAALLKVSE 1796
Query: 322 EALFQVEYDVATPDT-------------VANASGPLMVEIVKTPGSALGISLT--TTSLR 366
+L + ++ T + G VE+ K P +LGIS+ S
Sbjct: 1797 GSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL 1856
Query: 367 NKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEIL 426
I I + P V ++ L GD I++I GTS E + +A LL + S + ++++
Sbjct: 1857 GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV 1916
Score = 81.3 bits (199), Expect = 5e-15
Identities = 142/702 (20%), Positives = 269/702 (38%), Gaps = 81/702 (11%)
Query: 146 VELIKKEGSTLGLTISGGTDKDGKPRVSNLRPG---------GLAARSDLLNIGDYIRSV 196
VEL ++ +LG++I GG + + G A ++ L GD I V
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 197 NGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFG 256
+G+ L H++ + ++ G VV V+ + P P ++ + N F
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFA 1271
Query: 257 FVLRGGAHEDGHKS----RPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATA 312
L+ A + +S L V P P+ G+ H +
Sbjct: 1272 DSLQINADKAPSQSESEPEKAPLCSVPPPPPS----------------AFAEMGSDHTQS 1315
Query: 313 LATLRQCSHEALFQVEYDVA---TPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKS 369
A+ + S + + E+ + + +G L + ++ S LG+SL R++
Sbjct: 1316 SAS--KISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM 1373
Query: 370 VITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVP 429
+ I I P + G L D +L I+G + S A+ ++ KV+
Sbjct: 1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVK------- 1426
Query: 430 QSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHC----RMPTWATPAGQDQSRSL 485
++ ++ + +++ C + P P + T T D + L
Sbjct: 1427 -----------IIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDL 1475
Query: 486 SSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGG 545
S S + H + L G T G + EH ++ + G
Sbjct: 1476 S----SFKNVQHLELPKDQGGL--GIAISEEDTLSGVIIKSLTEH--GVAATDGRLKVGD 1527
Query: 546 QIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPA--ERCGLLQVG 603
QI+ + VV G+ ++ + T ++ + PDS A G
Sbjct: 1528 QILAVDDEIVV-------GYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE 1580
Query: 604 DRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRS 663
+ S + + + G+ E + +R+ + + + +IP T +++ K R+
Sbjct: 1581 KKNSSQSLMVPQSGSPEP--ESIRNTSRSSTPAIFASDPATCPIIPGCET-TIEISKGRT 1637
Query: 664 VELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQI 723
LG++I S +II ++ + A + G L GD++L ++ I L ++A+ +
Sbjct: 1638 -GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINV 1696
Query: 724 LRQCEDLVKLKIRKDEDNSDELETTGAVSYTVEL-KRYGGPLGITISGTEEPFDPIVISG 782
LRQ V+L + +DE E E + T+EL K+ G LG++I G + +S
Sbjct: 1697 LRQTPQRVRLTLYRDEAPYKEEEVCDTL--TIELQKKPGKGLGLSIVGKRND-TGVFVSD 1753
Query: 783 LTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVA 824
+ K G+A+ G + GD+IL +N ++ LL+V+
Sbjct: 1754 IVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795
Score = 79.3 bits (194), Expect = 2e-14
Identities = 146/733 (19%), Positives = 265/733 (36%), Gaps = 179/733 (24%)
Query: 246 VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLH 305
+++ K +S G + A++DG +++ + GG R+G + +GD +LS++
Sbjct: 1009 INIAKGNSSLGMTV--SANKDG---LGMIVRSIIHGGAISRDGRIAIGDCILSINEESTI 1063
Query: 306 GASHATALATLRQCS--------------HEALFQVEYDVATPDTVA------------- 338
++A A A LR+ S H F++ + +A
Sbjct: 1064 SVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIP 1123
Query: 339 ---------------------NASGPLMVEIVKTPGSALGISLTT-----TSLRNKSV-- 370
N + P VE+ + P +LGIS+ + L N V
Sbjct: 1124 ELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMR 1183
Query: 371 -ITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVP 429
I I + S ++G L PGD I+ +DG + S +A + + V + +
Sbjct: 1184 GIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSII 1243
Query: 430 QSQRPLRPQRQVVK--VQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSS 487
RP++ + + + + P S + + P+ + + + L S
Sbjct: 1244 N-----RPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQS--ESEPEKAPLCS 1296
Query: 488 TPFSSPT-LNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQ 546
P P+ S + S+ + SQ + G + RE +L
Sbjct: 1297 VPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTL------------ 1344
Query: 547 IVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRV 606
T ++ SG GL L G + + I+P+ A + G LQ+ D +
Sbjct: 1345 ---TGELHMIELEKGHSGLGLSLAGN---KDRSRMSVFIVGIDPNGAAGKDGRLQIADEL 1398
Query: 607 LSINGIATEDGTMEEANQLLRDAALAHKVVL----------------------------- 637
L ING + + A+ +++ A K++
Sbjct: 1399 LEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQ 1458
Query: 638 --EVE-----FDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGS 690
E E D A + H++LPK + LGI IS G +II + +
Sbjct: 1459 NKETEPTVTTSDAAVDLSSFKNVQHLELPKDQG-GLGIAISEEDTLSG--VIIKSLTEHG 1515
Query: 691 VAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDEL-ETTG 749
VA G L+ GD++LA+D+ + P+E + +L+ + VKL I + +S + G
Sbjct: 1516 VAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAG 1575
Query: 750 AVS-------------------------------------------------YTVELKRY 760
A S T+E+ +
Sbjct: 1576 AASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKG 1635
Query: 761 GGPLGITI-SGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIH 819
LG++I G++ I+I + + G A + G + GD+IL +N + L+ EAI+
Sbjct: 1636 RTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAIN 1695
Query: 820 LLQVAGETVTLKI 832
+L+ + V L +
Sbjct: 1696 VLRQTPQRVRLTL 1708
Score = 79.0 bits (193), Expect = 2e-14
Identities = 96/371 (25%), Positives = 156/371 (42%), Gaps = 75/371 (20%)
Query: 549 HTETTEVVLCGDPLSGFGLQLQG---------GIFATETLSSPPLVCFIEPDSPAERCGL 599
H E E L P G G + G GIF E I+ S A R G
Sbjct: 134 HVEVFE--LLKPPSGGLGFSVVGLRSENRGELGIFVQE----------IQEGSVAHRDGR 181
Query: 600 LQVGDRVLSINGIATEDG-TMEEANQLLRDAALAHKVVLE-----------VEFDVAESV 647
L+ D++L+ING A + T ++A +L+ A ++V+ V + +
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAAS 241
Query: 648 IPSSGTFHVKLPKKRSVEL-----GITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGD 702
S+ + V ++EL G+ K +I+ I G VA + G L GD
Sbjct: 242 TISAHSNPVHWQHMETIELVNDGSGLGFGIIGGK-ATGVIVKTILPGGVADQHGRLCSGD 300
Query: 703 KLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK------------------DEDNSDE 744
+L I + L E Q+LRQC + VKL I + ++ E
Sbjct: 301 HILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPE 360
Query: 745 LETTGAV-------SYTVELKRYGGPLGITISGT--EEPFDP--IVISGLTKRGLAERTG 793
L + ++ VEL + LGITI+G ++ +P I + +TK E G
Sbjct: 361 LRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDG 420
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK---QLDRPLLPRKSGSLSE 850
I +GD+I+A++ +L+G +A+ +L+ G+TV L + + + + L+ R+
Sbjct: 421 RIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSRE----DV 476
Query: 851 TSDADEDPADA 861
T DAD P +A
Sbjct: 477 TKDADLSPVNA 487
Score = 73.6 bits (179), Expect = 1e-12
Identities = 83/330 (25%), Positives = 132/330 (40%), Gaps = 61/330 (18%)
Query: 140 FRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGI 199
F+ + +EL K +G LG+ IS G + +L G+AA L +GD I +V+
Sbjct: 1478 FKNVQHLELPKDQGG-LGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 200 HLTRLRHDEIITLLKNVGERVVLEVEYELP-----------------------------P 230
+ ++ I+LLK V L + E P
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGS 1595
Query: 231 PAPE--------NNPRIISK-------------TVDVSLYKEGNSFGFVLRGGAHEDGHK 269
P PE + P I + T+++S + G G + GG+
Sbjct: 1596 PEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTG--LGLSIVGGSDT---L 1650
Query: 270 SRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEY 329
+++ V G A ++G L GD++L V+GI L A+H A+ LRQ +
Sbjct: 1651 LGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
Query: 330 DVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALH 389
D A P L +E+ K PG LG+S+ RN + + + I + D G L
Sbjct: 1711 DEA-PYKEEEVCDTLTIELQKKPGKGLGLSI--VGKRNDTGVFVSDIVKGGIADADGRLM 1767
Query: 390 PGDHILSIDGTSMEHCSLLEATKLLASISE 419
GD IL ++G + + + EA L +SE
Sbjct: 1768 QGDQILMVNGEDVRNAT-QEAVAALLKVSE 1796
Score = 73.6 bits (179), Expect = 1e-12
Identities = 68/305 (22%), Positives = 131/305 (42%), Gaps = 39/305 (12%)
Query: 47 PGEGQGLH--------GEPLPDHCQGTGGQIDPSLGRGGRAKQRGSRGSWWAAGETIANM 98
PG+G GL G + D +G D L +G + A E +A +
Sbjct: 1732 PGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAAL 1791
Query: 99 LCGLSRETPGEADDGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGL 158
L + + G + G + + + ++ ++ E +G+ VE+ K +LG+
Sbjct: 1792 L----KVSEGSLSSFTFPLSGSSTSES-LESSSKKNALASEIQGLRTVEMKKGPTDSLGI 1846
Query: 159 TISGGTDK---DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKN 215
+I+GG D ++ + P G+AA++ L +GD I ++ G + H + + LLKN
Sbjct: 1847 SIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKN 1906
Query: 216 VGERVVLEV-----------EYELPPPAPENNPRIISKTV-----------DVSLYKEGN 253
+ ++V + P + + + S ++ ++L + +
Sbjct: 1907 ASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPD 1966
Query: 254 SFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATAL 313
GF + GG + H P+ + V G A +G LK GD++++V+G L G +H A+
Sbjct: 1967 GLGFSIVGG-YGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAV 2025
Query: 314 ATLRQ 318
A L++
Sbjct: 2026 AILKR 2030
Score = 67.0 bits (162), Expect = 1e-10
Identities = 79/328 (24%), Positives = 133/328 (40%), Gaps = 56/328 (17%)
Query: 551 ETTEVVLCGDPLSGFGLQLQG-----GIFATETLSSPPLVCFIEPDSPAERCGLLQVGDR 605
+T + L P G GL + G G+F ++ + A+ G L GD+
Sbjct: 1722 DTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKG----------GIADADGRLMQGDQ 1771
Query: 606 VLSINGIATEDGTMEEANQLLR--DAALAHKVVLEVEFDVAESVIPSS----------GT 653
+L +NG + T E LL+ + +L+ +ES+ SS G
Sbjct: 1772 ILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGL 1831
Query: 654 FHVKLPKKRSVELGITISSA--SRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIR 711
V++ K + LGI+I+ S P+ I+ + VA +T L GD+++ I
Sbjct: 1832 RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891
Query: 712 LDNCPMEDAVQILRQCEDLVKLKI-----------RKDEDNSDELETTGAVSYTVELKRY 760
+ AV +L+ +++++ + E S L TG S ++
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL 1951
Query: 761 GGP-------------LGITI-SGTEEPFD--PIVISGLTKRGLAERTGAIHVGDRILAI 804
G P LG +I G P PI + + +G A G + GD+I+A+
Sbjct: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAV 2011
Query: 805 NNVSLKGRPLSEAIHLLQVAGETVTLKI 832
N SL+G EA+ +L+ TVTL +
Sbjct: 2012 NGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 63.9 bits (154), Expect = 8e-10
Identities = 84/341 (24%), Positives = 129/341 (37%), Gaps = 45/341 (13%)
Query: 127 VSLACRRQSIP---EEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAAR 183
V L R P EE +EL KK G LGL+I G + G VS++ GG+A
Sbjct: 1704 VRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTG-VFVSDIVKGGIADA 1762
Query: 184 SDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKT 243
L GD I VNG + + + LLK V E + + L + + SK
Sbjct: 1763 DGRLMQGDQILMVNGEDVRNATQEAVAALLK-VSEGSLSSFTFPLSGSSTSESLESSSKK 1821
Query: 244 VDVSLYKEG-----------NSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKV 292
++ +G +S G + GG P+ + + P G A + L+V
Sbjct: 1822 NALASEIQGLRTVEMKKGPTDSLGISIAGGVGSP-LGDVPIFIAMMHPTGVAAQTQKLRV 1880
Query: 293 GDRLLSVDGIPLHGASHATALATLRQCSHEALFQV----EYDVATPDTVANASGPL---- 344
GDR++++ G G +H A+ L+ S QV + V T AS L
Sbjct: 1881 GDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTG 1940
Query: 345 -----------------MVEIVKTPGSALGISLT--TTSLRNKSVITIDRIKPASVVDRS 385
+ + + P LG S+ S I + +
Sbjct: 1941 LTSSSIFQDDLGPPQCKSITLERGP-DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASED 1999
Query: 386 GALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEIL 426
G L GD I++++G S+E + EA +L V L +L
Sbjct: 2000 GRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 61.6 bits (148), Expect = 4e-09
Identities = 75/302 (24%), Positives = 128/302 (42%), Gaps = 48/302 (15%)
Query: 589 EPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEF-----DV 643
+ +S E+ L V S D T A+++ +D V E EF ++
Sbjct: 1284 QSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD------VDKEDEFGYSWKNI 1337
Query: 644 AESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDK 703
E +G H+ +K LG++++ + + I I A + G L+ D+
Sbjct: 1338 RERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADE 1397
Query: 704 LLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED------------------NSDEL 745
LL I+ L ++A I++ VK+ +++D NS+ L
Sbjct: 1398 LLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENL 1457
Query: 746 ---ETTGAVSYT--------------VELKRYGGPLGITISGTEEPFDPIVISGLTKRGL 788
ET V+ + +EL + G LGI IS E+ ++I LT+ G+
Sbjct: 1458 QNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS-EEDTLSGVIIKSLTEHGV 1516
Query: 789 AERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKI-KKQLDRPLLPRKSGS 847
A G + VGD+ILA+++ + G P+ + I LL+ A TV L I + D +P +G+
Sbjct: 1517 AATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGA 1576
Query: 848 LS 849
S
Sbjct: 1577 AS 1578
Score = 54.3 bits (129), Expect = 6e-07
Identities = 64/243 (26%), Positives = 97/243 (39%), Gaps = 64/243 (26%)
Query: 149 IKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNG---IHLTRL- 204
I K S+LG+T+S D G V ++ GG +R + IGD I S+N I +T
Sbjct: 1011 IAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQ 1069
Query: 205 ------RHDEI------------------ITLLKNVGERVVLEVEYELP----PPAPE-- 234
RH I I+L + G + L++ P PE
Sbjct: 1070 ARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPERE 1129
Query: 235 -----------------NNPRIISKTVDVSLYKE-GNSFGFVLRGGAH-----EDGHKSR 271
N PR V L++E S G + GG +G R
Sbjct: 1130 EGEGEESELQNTAYSNWNQPR------RVELWREPSKSLGISIVGGRGMGSRLSNGEVMR 1183
Query: 272 PLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDV 331
+ + +V PA + G+LK GDR++ VDG+ L ASH A+ +R+ + +F V+ +
Sbjct: 1184 GIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSII 1243
Query: 332 ATP 334
P
Sbjct: 1244 NRP 1246
Score = 46.2 bits (108), Expect = 2e-04
Identities = 139/663 (20%), Positives = 242/663 (36%), Gaps = 138/663 (20%)
Query: 369 SVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASI-SEKVRLEILP 427
+VI I + P + ++ G L PGD ++ ++ ++E+ SL EA + L S VR+ +
Sbjct: 726 TVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVA- 784
Query: 428 VPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRP--------------GHCRMPTW 473
PL P+ V + L+ C + + +P T+
Sbjct: 785 ---KPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTF 841
Query: 474 ATPAGQDQSRSLSSTPFSSPTLNHAFSC----NNPSTLPRGSQPMSPRTTMGRRRQRRRE 529
+P + S+ ST S +L H SC N S+LP S P P+ + +
Sbjct: 842 ESPYSPEND-SIYSTQASILSL-HGSSCGDGLNYGSSLP--SSP--PKDVIENSCDPVLD 895
Query: 530 HKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATET-LSSPPLVCFI 588
SL + Q +T + ++ + P SGF + A E + +
Sbjct: 896 LHMSLEELYTQNLLQRQDENTPSVDISM--GPASGFTINDYTPANAIEQQYECENTIVWT 953
Query: 589 EPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVI 648
E P+E ++ D + + LL ++LA E + ++V
Sbjct: 954 ESHLPSEVISSAELPS--------VLPDSAGKGSEYLLEQSSLA----CNAECVMLQNVS 1001
Query: 649 PSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAID 708
S + + K S LG+T+S+ K G +I+ I G R G + GD +L+I+
Sbjct: 1002 KESFERTINIAKGNS-SLGMTVSA--NKDGLGMIVRSIIHGGAISRDGRIAIGDCILSIN 1058
Query: 709 NIRLDNCPMEDAVQILRQ--------------CEDLVKLKI------------------- 735
+ A +LR+ E L + KI
Sbjct: 1059 EESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYT 1118
Query: 736 ----------RKDEDNSDELETTGAVSYT----VELKRYGGP-LGITISGTE-------- 772
+ E EL+ T ++ VEL R LGI+I G
Sbjct: 1119 GRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSN 1178
Query: 773 -EPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLK 831
E I I + + A + G + GDRI+ ++ + L+ +A+ ++ AG V
Sbjct: 1179 GEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFM 1238
Query: 832 IKKQLDRPLLPRKSGSLSETSDADEDPADALKGGL-PAARFSPAVPSVDSAVESWDSSAT 890
++ ++R PRKS P +L L P FS P DS + D
Sbjct: 1239 VQSIINR---PRKS------------PLPSLLHNLYPKYNFSSTNPFADSLQINAD---- 1279
Query: 891 EGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPT--EPRRTSYTPTPADESFPEEEEE 948
+A ++ + E+ P PPP+ + +T + A + + ++E
Sbjct: 1280 ------------KAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKE 1327
Query: 949 DDW 951
D++
Sbjct: 1328 DEF 1330
Score = 42.0 bits (97), Expect = 0.003
Identities = 54/248 (21%), Positives = 91/248 (36%), Gaps = 53/248 (21%)
Query: 120 KDAGGADVSLACRRQSIPEEFRGITVVELIK-KEGSTLGLTISGGTDKDGKPRVSNLRPG 178
+DA + +L + Q I I V + K E S LG+++ G + ++ P
Sbjct: 528 EDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATV---GHHFIRSVLPE 584
Query: 179 GLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPEN--- 235
G S L GD + VNGI L H +++ +LK + V + PP ++
Sbjct: 585 GPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELD 644
Query: 236 -----------NPRI-------ISKTVD----------------------------VSLY 249
P + S+T D + L
Sbjct: 645 SLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELE 704
Query: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309
K GF + S +++ + PGG A+++G L GDRL+ V+ + L +S
Sbjct: 705 KGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSL 764
Query: 310 ATALATLR 317
A+ L+
Sbjct: 765 EEAVEALK 772
Score = 38.1 bits (87), Expect = 0.048
Identities = 25/86 (29%), Positives = 48/86 (55%), Gaps = 6/86 (6%)
Query: 1052 GFSVSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAVPLLAEAG 1110
G +S+G + +G+++ V D PA + G L+P DR+++V+ + RD AV + +AG
Sbjct: 1173 GSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAG 1232
Query: 1111 DVLELIISRKPHTAHSSRAPRSPGPS 1136
+ + ++ + +R +SP PS
Sbjct: 1233 NPVVFMVQ-----SIINRPRKSPLPS 1253
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 95.1 bits (235), Expect = 3e-19
Identities = 179/830 (21%), Positives = 292/830 (35%), Gaps = 193/830 (23%)
Query: 137 PEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSV 196
P E +G + ++K G T+ GG + D ++ +L G AA + GD I SV
Sbjct: 463 PSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522
Query: 197 NGIHLTRLRHDEIITLLKN--VGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNS 254
N + H +++ + ++ +G V LE+ P P ++P T L KE
Sbjct: 523 NDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKE--- 579
Query: 255 FGFVLRGGAHEDGHKSRPLVLTYV------RPGGPADREGSLKVGDRLLSVDGIPLHGAS 308
++ G D S V RP PAD + S G P S
Sbjct: 580 -PIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASN--------SSHGYPNDTVS 630
Query: 309 HATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNK 368
A+++AT P+ + V IVK P +G T
Sbjct: 631 LASSIAT-----------------QPELIT-------VHIVKGP---MGFGFTIADSPGG 663
Query: 369 SVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLL------ASISEKVR 422
R+K R L GD I+ ++ +++ + + +L + ++ V+
Sbjct: 664 GG---QRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 423 LEILPVPQ---SQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQ 479
LPVP+ +PL + Q S HR S H+ P H P +
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHR------SLHTASPSHSTQVLPEFPPAE 774
Query: 480 DQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASS 539
Q+ T S F S ++PMSP G + R +S +
Sbjct: 775 AQAP--DQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGEC 832
Query: 540 TVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGL 599
+ P Q + + +GFG ++ GG P + I P A+ G
Sbjct: 833 PI-PDYQ------EQDIFLWRKETGFGFRILGG----NEPGEPIYIGHIVPLGAADTDGR 881
Query: 600 LQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDV------AESVIPSSGT 653
L+ GD ++ ++G + + QL++ AA V L V V E+ +PS +
Sbjct: 882 LRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPAS 941
Query: 654 FH------VKLPKKRSVELGI-----TISSASR--------------------------- 675
H L +++ G T+SS S
Sbjct: 942 SHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 1001
Query: 676 KRGEP-----LIISDIKK-----------------------GSVAHRTGTLEPGDKLLAI 707
+RGE +I+S + + GS A R G L+ GD++LA+
Sbjct: 1002 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1061
Query: 708 DNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVS--------------- 752
+ + N D V ++++ + V L+I +++S+ T A
Sbjct: 1062 NGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGT 1121
Query: 753 ----------------------------YTVELKRYGGPLGITISGTEEPFDPIVISGLT 784
YTVEL+R G ++ G E + + L
Sbjct: 1122 QETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLA 1181
Query: 785 KRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ G AER G + +GD IL IN + K S AI L++ G V L +K+
Sbjct: 1182 EDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
Score = 52.4 bits (124), Expect = 2e-06
Identities = 46/213 (21%), Positives = 76/213 (35%), Gaps = 58/213 (27%)
Query: 171 RVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV------ 224
++ + G A R L +GD I +VNG +T H +I+ L+K G V L +
Sbjct: 1036 KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1095
Query: 225 -----------------------------------------EYELPPPAPENNPRIISKT 243
E++ P E +
Sbjct: 1096 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQD------F 1149
Query: 244 VDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIP 303
V L + FGF LRGG + L + + GPA+R G +++GD +L ++G
Sbjct: 1150 YTVELERGAKGFGFSLRGGREYN----MDLYVLRLAEDGPAERCGKMRIGDEILEINGET 1205
Query: 304 LHGASHATALATLRQCSHEA-LFQVEYDVATPD 335
H+ A+ ++ LF D + P+
Sbjct: 1206 TKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPE 1238
Score = 41.2 bits (95), Expect = 0.006
Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 8/91 (8%)
Query: 149 IKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDE 208
+++ G ++ GG + + V L G A R + IGD I +NG ++H
Sbjct: 1154 LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1213
Query: 209 IITLLKNVGERVVLEV--------EYELPPP 231
I L+KN G RV L + EY + PP
Sbjct: 1214 AIELIKNGGRRVRLFLKRGDGSVPEYAMIPP 1244
Score = 38.9 bits (89), Expect = 0.028
Identities = 32/138 (23%), Positives = 56/138 (40%), Gaps = 5/138 (3%)
Query: 765 GITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVA 824
G I G EP +PI I + G A+ G + GD ++ ++ + G+ + L+Q A
Sbjct: 852 GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911
Query: 825 GE----TVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDS 880
+ +T++ K P + S + + + PA + ++ +V S
Sbjct: 912 AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSS 971
Query: 881 AVESWDSSATEGGFGGPG 898
S S GG GG G
Sbjct: 972 GSGS-TSGIGSGGGGGSG 988
Score = 38.1 bits (87), Expect = 0.048
Identities = 38/167 (22%), Positives = 68/167 (40%), Gaps = 10/167 (5%)
Query: 756 ELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLS 815
+L++ G T+ G +EP + + I L G A G + GD I+++N+ + G +
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 816 EAIHLLQ--VAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPA----A 869
+ + + Q G +V L++ + P P + TS A D + G A
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
Query: 870 RFSPAVPSVDSAVESWDSS----ATEGGFGGPGSYTPQAAARGTTPQ 912
S V+ ++ SS A+ G P A++ T P+
Sbjct: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPE 640
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 94.7 bits (234), Expect = 4e-19
Identities = 179/831 (21%), Positives = 292/831 (35%), Gaps = 194/831 (23%)
Query: 137 PEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSV 196
P E +G + ++K G T+ GG + D ++ +L G AA + GD I SV
Sbjct: 463 PSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522
Query: 197 NGIHLTRLRHDEIITLLKN--VGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNS 254
N + H +++ + ++ +G V LE+ P P ++P T L KE
Sbjct: 523 NDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKE--- 579
Query: 255 FGFVLRGGAHEDGHKSRPLVLTYV------RPGGPADREGSLKVGDRLLSVDGIPLHGAS 308
++ G D S V RP PAD + S G P S
Sbjct: 580 -PIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASN--------SSHGYPNDTVS 630
Query: 309 HATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNK 368
A+++AT P+ + V IVK P +G T
Sbjct: 631 LASSIAT-----------------QPELIT-------VHIVKGP---MGFGFTIADSPGG 663
Query: 369 SVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLL------ASISEKVR 422
R+K R L GD I+ ++ +++ + + +L + ++ V+
Sbjct: 664 GG---QRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 423 LEILPVPQ---SQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQ 479
LPVP+ +PL + Q S HR S H+ P H P +
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHR------SLHTASPSHSTQVLPEFPPAE 774
Query: 480 DQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASS 539
Q+ T S F S ++PMSP G + R +S +
Sbjct: 775 AQAP--DQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGEC 832
Query: 540 TVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGL 599
+ P Q + + +GFG ++ GG P + I P A+ G
Sbjct: 833 PI-PDYQ------EQDIFLWRKETGFGFRILGG----NEPGEPIYIGHIVPLGAADTDGR 881
Query: 600 LQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDV------AESVIPSSGT 653
L+ GD ++ ++G + + QL++ AA V L V V E+ +PS +
Sbjct: 882 LRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPAS 941
Query: 654 FH------VKLPKKRSVELGI-----TISSASR--------------------------- 675
H L +++ G T+SS S
Sbjct: 942 SHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 1001
Query: 676 KRGEP-----LIISDIKK------------------------GSVAHRTGTLEPGDKLLA 706
+RGE +I+S + + GS A R G L+ GD++LA
Sbjct: 1002 RRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILA 1061
Query: 707 IDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVS-------------- 752
++ + N D V ++++ + V L+I +++S+ T A
Sbjct: 1062 VNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQG 1121
Query: 753 -----------------------------YTVELKRYGGPLGITISGTEEPFDPIVISGL 783
YTVEL+R G ++ G E + + L
Sbjct: 1122 TQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRL 1181
Query: 784 TKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ G AER G + +GD IL IN + K S AI L++ G V L +K+
Sbjct: 1182 AEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1232
Score = 54.3 bits (129), Expect = 6e-07
Identities = 51/242 (21%), Positives = 86/242 (35%), Gaps = 60/242 (24%)
Query: 142 GITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHL 201
G +V + + + G T +G ++ + G A R L +GD I +VNG +
Sbjct: 1010 GFVIVSSVSRPEA--GTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSI 1067
Query: 202 TRLRHDEIITLLKNVGERVVLEV------------------------------------- 224
T H +I+ L+K G V L +
Sbjct: 1068 TNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRN 1127
Query: 225 ----------EYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLV 274
E++ P E + V L + FGF LRGG + L
Sbjct: 1128 TTKPKQESQFEFKAPQATQEQD------FYTVELERGAKGFGFSLRGGREYN----MDLY 1177
Query: 275 LTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEA-LFQVEYDVAT 333
+ + GPA+R G +++GD +L ++G H+ A+ ++ LF D +
Sbjct: 1178 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSV 1237
Query: 334 PD 335
P+
Sbjct: 1238 PE 1239
Score = 38.9 bits (89), Expect = 0.028
Identities = 32/138 (23%), Positives = 56/138 (40%), Gaps = 5/138 (3%)
Query: 765 GITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVA 824
G I G EP +PI I + G A+ G + GD ++ ++ + G+ + L+Q A
Sbjct: 852 GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911
Query: 825 GE----TVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDS 880
+ +T++ K P + S + + + PA + ++ +V S
Sbjct: 912 AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSS 971
Query: 881 AVESWDSSATEGGFGGPG 898
S S GG GG G
Sbjct: 972 GSGS-TSGIGSGGGGGSG 988
Score = 38.1 bits (87), Expect = 0.048
Identities = 38/167 (22%), Positives = 68/167 (40%), Gaps = 10/167 (5%)
Query: 756 ELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLS 815
+L++ G T+ G +EP + + I L G A G + GD I+++N+ + G +
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 816 EAIHLLQ--VAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPA----A 869
+ + + Q G +V L++ + P P + TS A D + G A
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
Query: 870 RFSPAVPSVDSAVESWDSS----ATEGGFGGPGSYTPQAAARGTTPQ 912
S V+ ++ SS A+ G P A++ T P+
Sbjct: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPE 640
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 90.1 bits (222), Expect = 1e-17
Identities = 85/319 (26%), Positives = 133/319 (41%), Gaps = 63/319 (19%)
Query: 156 LGLTISGGTDK------DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEI 209
LG +I+GG D VS + GG A R+ L +GD + S+NG+ +T RHD
Sbjct: 872 LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHA 931
Query: 210 ITLLKNVGERVVLEVEYE----LPP-PAPENNPRIISKTV-------------------- 244
++LL + L +E E LPP P P ++P +
Sbjct: 932 VSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSL 991
Query: 245 ------------DVSLYKEGNSFGFVLRGGAHEDGH----KSRPLVLTYVRPGGPADREG 288
++ L + G G + GG+ H + + ++ V P G A R G
Sbjct: 992 LAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG 1051
Query: 289 SLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEI 348
L+VGDR+L+V+G + A+H A++ L + E V D A P G + I
Sbjct: 1052 -LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPP-------GLRELCI 1103
Query: 349 VKTPGSALGISLTTTSLRN--------KSVITIDRIKPASVVDRSGALHPGDHILSIDGT 400
K PG LGIS+ + + I I ++ P R G L G +L ++
Sbjct: 1104 QKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQ 1163
Query: 401 SMEHCSLLEATKLLASISE 419
S+ + EA +LL S+ +
Sbjct: 1164 SLLGLTHGEAVQLLRSVGD 1182
Score = 77.4 bits (189), Expect = 7e-14
Identities = 142/596 (23%), Positives = 215/596 (36%), Gaps = 138/596 (23%)
Query: 564 GFGLQLQGGIFATETLSSPP--LVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
G G + GG +T + V I A R G LQVGDRVLSING+ + +
Sbjct: 871 GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDH 930
Query: 622 ANQLLRDAALAHKVVLEVEFD--VAESVIPSSG--------------------------- 652
A LL A+ ++LE E + S +P S
Sbjct: 931 AVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990
Query: 653 -----------TFHVKLPKKRSVELGITISSASRKRGEP-------LIISDIKKGSVAHR 694
++LP+ LG++I S P + IS + +A R
Sbjct: 991 LLAAALEGPYPVEEIRLPRAGG-PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR 1049
Query: 695 TGTLEPGDKLLAIDNIRLDNCPMEDAVQ-ILRQCEDLVKLKIRKDEDNSDELETTGAVSY 753
+G L GD++LA++ + + ++AV +LR C +L L +R+D G
Sbjct: 1050 SG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLEL-SLLVRRDP------APPGLREL 1101
Query: 754 TVELKRYGGPLGITISG-----TEEPFDP----IVISGLTKRGLAERTGAIHVGDRILAI 804
++ K G LGI+I G P DP I IS ++ G A R G + VG R+L +
Sbjct: 1102 CIQ-KAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160
Query: 805 NNVSLKGRPLSEAIHLLQVAGETVT----------------------------------- 829
N SL G EA+ LL+ G+T+T
Sbjct: 1161 NQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNS 1220
Query: 830 LKIKKQLDRPLLPRKSGSLSET--------SDADEDPADALK---------GGLPAARFS 872
L+ +DR L P G E +A E L+ +P+A
Sbjct: 1221 LESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSV 1280
Query: 873 PAVPSVDSAVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTS 932
VPS + + +S + G P +P R + S PP +
Sbjct: 1281 QRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQP 1340
Query: 933 YTPTPADE----SFPEEEEEDDWEPPTSPAPGPARE------EGFWRMFGEALEDLESCG 982
TP PA SF E ++ + E A GP + + +M E L+
Sbjct: 1341 PTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQ-K 1399
Query: 983 QSELLRELEASIMTGTVQRVALEGRPGHRPWQRGRE---VRASPAEMEELLLPTPL 1035
++++LRE + G R+AL+G Q + SP + P PL
Sbjct: 1400 RAQMLRE---AAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPL 1452
Score = 75.1 bits (183), Expect = 4e-13
Identities = 131/546 (23%), Positives = 199/546 (36%), Gaps = 126/546 (23%)
Query: 238 RIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKS--RPLVLTYVRPGGPADREGSLKVGDR 295
RI + + +++ ++ G + GG +K + ++ V GPA R G ++VGD+
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDK 779
Query: 296 LLSVDGIPLHGASHATALATLRQCS--------HEALFQVEYDVA--------------- 332
LL V+G+ L GA H A+ LR E + + E V
Sbjct: 780 LLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRER 839
Query: 333 ------TPDTVANASGPLM---VEIVKTPGSALGISL-----TTTSLRNKSVITIDRIKP 378
P + GPL V + LG S+ +T + I + RI
Sbjct: 840 RGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAE 899
Query: 379 ASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQ 438
R+G L GD +LSI+G + A LL + S + L L ++ PL P
Sbjct: 900 GGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL--LLEREAGGPLPPS 957
Query: 439 RQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHA 498
P HS P T T A + + P +P+L A
Sbjct: 958 -------------------PLPHSSPPTAAVATTSITTA----TPGVPGLPSLAPSLLAA 994
Query: 499 FSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLC 558
G P+ + R ++ L S VG H
Sbjct: 995 --------ALEGPYPV----------EEIRLPRAGGPLGLSIVGGSDHSSHP-------- 1028
Query: 559 GDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGT 618
FG+Q + G+F ++ L P A R G L+VGDR+L++NG D T
Sbjct: 1029 ------FGVQ-EPGVFISKVL----------PRGLAARSG-LRVGDRILAVNGQDVRDAT 1070
Query: 619 MEEA-NQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKR 677
+EA + LLR LE+ V P G + + K LGI+I +R
Sbjct: 1071 HQEAVSALLRPC-------LELSLLVRRDPAP-PGLRELCIQKAPGERLGISIRGGARGH 1122
Query: 678 G--------EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCED 729
E + IS + A R G L G +LL ++ L +AVQ+LR D
Sbjct: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
Query: 730 LVKLKI 735
+ + +
Sbjct: 1183 TLTVLV 1188
Score = 74.3 bits (181), Expect = 6e-13
Identities = 96/368 (26%), Positives = 145/368 (39%), Gaps = 58/368 (15%)
Query: 149 IKKEGSTLGLTISGGTDKDGKPR--------VSNLRPGGLAARSDLLNIGDYIRSVNGIH 200
+ + G LGL+I GG+D P +S + P GLAARS L +GD I +VNG
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGL-RVGDRILAVNGQD 1065
Query: 201 LTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLR 260
+ H E ++ L + L V + PP I K G G +R
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE--LCIQKA-------PGERLGISIR 1116
Query: 261 GGAHEDGHKSRP-------LVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATAL 313
GGA GH P + ++ V P G A R+G L+VG RLL V+ L G +H A+
Sbjct: 1117 GGAR--GHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAV 1174
Query: 314 ATLRQCSHEALFQV--EYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVI 371
LR V ++ +T + + G ++ P +A GI + +S+
Sbjct: 1175 QLLRSVGDTLTVLVCDGFEASTDAALEVSPG-----VIANPFAA-GIGHRNSL---ESIS 1225
Query: 372 TIDR----IKPASVVDRSG-ALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEIL 426
+IDR P + G LH G G ++ L + LA++ ++ +
Sbjct: 1226 SIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKL--DYRALAAVPSAGSVQRV 1283
Query: 427 P-------------VPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTW 473
P P Q+P P +Q +R VP+ H P + PT
Sbjct: 1284 PSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTP 1343
Query: 474 ATPAGQDQ 481
A +Q
Sbjct: 1344 GPAASPEQ 1351
Score = 68.6 bits (166), Expect = 3e-11
Identities = 89/379 (23%), Positives = 150/379 (39%), Gaps = 92/379 (24%)
Query: 149 IKKEGSTLGLTISGGTDK------DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLT 202
I ++ LG++I+GG D +S + G AAR+ + +GD + VNG+ L
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGV-RVGDKLLEVNGVALQ 789
Query: 203 RLRHDEIITLLKNVGERVVLEVEYE----------LPPPAPEN----------------- 235
H E + L+ G V + V E + P PE+
Sbjct: 790 GAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLL 849
Query: 236 ---NPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKS--RPLVLTYVRPGGPADREGSL 290
+P + + L + GF + GG +++ + ++ + GG A R G+L
Sbjct: 850 PPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTL 909
Query: 291 KVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDV-----------ATPDTVAN 339
+VGDR+LS++G+ + A H A++ L S +E + ++P T A
Sbjct: 910 QVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAV 969
Query: 340 AS--------------------------GPLMVEIVKTP--GSALGISLTTTSLRN---- 367
A+ GP VE ++ P G LG+S+ S +
Sbjct: 970 ATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPF 1029
Query: 368 ---KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLL----ASISEK 420
+ + I ++ P + RSG L GD IL+++G + + EA L +S
Sbjct: 1030 GVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLL 1088
Query: 421 VRLEILPVPQSQRPLRPQR 439
VR + P P R L Q+
Sbjct: 1089 VRRD--PAPPGLRELCIQK 1105
Score = 63.2 bits (152), Expect = 1e-09
Identities = 68/273 (24%), Positives = 109/273 (39%), Gaps = 54/273 (19%)
Query: 667 GITISSASRKRGEP-------LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMED 719
G+ IS A K P + IS + + A R G + GDKLL ++ + L +
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795
Query: 720 AVQILRQCEDLVKLKI-----------------RKDEDNSDELETTGAVSYTVELKRYGG 762
AV+ LR V++++ R ++D S G + + G
Sbjct: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPG 855
Query: 763 PL---------------GITISGTE--EPFDP----IVISGLTKRGLAERTGAIHVGDRI 801
PL G +I+G + P+ I +S + + G A R G + VGDR+
Sbjct: 856 PLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRV 915
Query: 802 LAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADA 861
L+IN V + A+ LL A T+ L ++++ PL P L +S P A
Sbjct: 916 LSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPP---SPLPHSS-----PPTA 967
Query: 862 LKGGLPAARFSPAVPSVDSAVESWDSSATEGGF 894
+P VP + S S ++A EG +
Sbjct: 968 AVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
Score = 45.8 bits (107), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 12/108 (11%)
Query: 126 DVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGT-DKDGKPR--------VSNLR 176
++SL RR P R + + K G LG++I GG G PR +S +
Sbjct: 1084 ELSLLVRRDPAPPGLRELCIQ---KAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140
Query: 177 PGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV 224
P G A R L +G + VN L L H E + LL++VG+ + + V
Sbjct: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 42.0 bits (97), Expect = 0.003
Identities = 58/251 (23%), Positives = 96/251 (38%), Gaps = 55/251 (21%)
Query: 904 AAARGTTPQERRP----GWLRGSPPPTEPRRTSYTPTPADESFPEEEEEDDWEPPTSPAP 959
A +G P P GW G P PR +E P+EEEE++ E +
Sbjct: 627 ALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQK-EEEEEEEGSPQEEEEEEEEENRAEEE 685
Query: 960 GPAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGTVQRVALEGRPGHRPWQRGREV 1019
+ EE ED E A + +V+ V+ + + +
Sbjct: 686 EASTEE----------EDKEG-----------AVVSAPSVKGVSFD---------QANNL 715
Query: 1020 RASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLL-------EKGVYVHTVRPD 1072
PA +EE ++TL G S++ G ++G+++ V +
Sbjct: 716 LIEPARIEE---------EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
Query: 1073 GPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISR----KPHTAHSSR 1128
GPA R G++ D++L+VN V + + AV L AG +++ + R +P A +
Sbjct: 767 GPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTIT 826
Query: 1129 APRSPGPSSPR 1139
R SPR
Sbjct: 827 PLRPEDDYSPR 837
Score = 40.4 bits (93), Expect = 0.010
Identities = 35/102 (34%), Positives = 45/102 (44%), Gaps = 10/102 (9%)
Query: 1023 PAEMEELLLPT---PLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGG 1079
P +EE+ LP PL + + D H FG E GV++ V P G A R G
Sbjct: 999 PYPVEEIRLPRAGGPLGL-SIVGGSDHSSHPFGVQ------EPGVFISKVLPRGLAARSG 1051
Query: 1080 LQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKP 1121
L+ DR+L VN RD AV L L L++ R P
Sbjct: 1052 LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
Score = 38.9 bits (89), Expect = 0.028
Identities = 36/114 (31%), Positives = 48/114 (42%), Gaps = 13/114 (11%)
Query: 1032 PTPLEMHKVTLHKDPMRHDFGFSVSDG-------LLEKGVYVHTVRPDGPAHRGG-LQPF 1083
P PL V R GFS++ G + G++V + G AHR G LQ
Sbjct: 854 PGPLRQRHVACLARSER-GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 1084 DRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSPGPSS 1137
DRVL +N V + AV LL A + L++ R+ P SP P S
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREA----GGPLPPSPLPHS 962
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 90.1 bits (222), Expect = 1e-17
Identities = 85/319 (26%), Positives = 133/319 (41%), Gaps = 63/319 (19%)
Query: 156 LGLTISGGTDK------DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEI 209
LG +I+GG D VS + GG A R+ L +GD + S+NG+ +T RHD
Sbjct: 872 LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHA 931
Query: 210 ITLLKNVGERVVLEVEYE----LPP-PAPENNPRIISKTV-------------------- 244
++LL + L +E E LPP P P ++P +
Sbjct: 932 VSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSL 991
Query: 245 ------------DVSLYKEGNSFGFVLRGGAHEDGH----KSRPLVLTYVRPGGPADREG 288
++ L + G G + GG+ H + + ++ V P G A R G
Sbjct: 992 LAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG 1051
Query: 289 SLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEI 348
L+VGDR+L+V+G + A+H A++ L + E V D A P G + I
Sbjct: 1052 -LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPP-------GLRELCI 1103
Query: 349 VKTPGSALGISLTTTSLRN--------KSVITIDRIKPASVVDRSGALHPGDHILSIDGT 400
K PG LGIS+ + + I I ++ P R G L G +L ++
Sbjct: 1104 QKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQ 1163
Query: 401 SMEHCSLLEATKLLASISE 419
S+ + EA +LL S+ +
Sbjct: 1164 SLLGLTHGEAVQLLRSVGD 1182
Score = 77.4 bits (189), Expect = 7e-14
Identities = 142/596 (23%), Positives = 215/596 (36%), Gaps = 138/596 (23%)
Query: 564 GFGLQLQGGIFATETLSSPP--LVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
G G + GG +T + V I A R G LQVGDRVLSING+ + +
Sbjct: 871 GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDH 930
Query: 622 ANQLLRDAALAHKVVLEVEFD--VAESVIPSSG--------------------------- 652
A LL A+ ++LE E + S +P S
Sbjct: 931 AVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990
Query: 653 -----------TFHVKLPKKRSVELGITISSASRKRGEP-------LIISDIKKGSVAHR 694
++LP+ LG++I S P + IS + +A R
Sbjct: 991 LLAAALEGPYPVEEIRLPRAGG-PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR 1049
Query: 695 TGTLEPGDKLLAIDNIRLDNCPMEDAVQ-ILRQCEDLVKLKIRKDEDNSDELETTGAVSY 753
+G L GD++LA++ + + ++AV +LR C +L L +R+D G
Sbjct: 1050 SG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLEL-SLLVRRDP------APPGLREL 1101
Query: 754 TVELKRYGGPLGITISG-----TEEPFDP----IVISGLTKRGLAERTGAIHVGDRILAI 804
++ K G LGI+I G P DP I IS ++ G A R G + VG R+L +
Sbjct: 1102 CIQ-KAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160
Query: 805 NNVSLKGRPLSEAIHLLQVAGETVT----------------------------------- 829
N SL G EA+ LL+ G+T+T
Sbjct: 1161 NQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNS 1220
Query: 830 LKIKKQLDRPLLPRKSGSLSET--------SDADEDPADALK---------GGLPAARFS 872
L+ +DR L P G E +A E L+ +P+A
Sbjct: 1221 LESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSV 1280
Query: 873 PAVPSVDSAVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTS 932
VPS + + +S + G P +P R + S PP +
Sbjct: 1281 QRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQP 1340
Query: 933 YTPTPADE----SFPEEEEEDDWEPPTSPAPGPARE------EGFWRMFGEALEDLESCG 982
TP PA SF E ++ + E A GP + + +M E L+
Sbjct: 1341 PTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQ-K 1399
Query: 983 QSELLRELEASIMTGTVQRVALEGRPGHRPWQRGRE---VRASPAEMEELLLPTPL 1035
++++LRE + G R+AL+G Q + SP + P PL
Sbjct: 1400 RAQMLRE---AAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPL 1452
Score = 75.1 bits (183), Expect = 4e-13
Identities = 131/546 (23%), Positives = 199/546 (36%), Gaps = 126/546 (23%)
Query: 238 RIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKS--RPLVLTYVRPGGPADREGSLKVGDR 295
RI + + +++ ++ G + GG +K + ++ V GPA R G ++VGD+
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDK 779
Query: 296 LLSVDGIPLHGASHATALATLRQCS--------HEALFQVEYDVA--------------- 332
LL V+G+ L GA H A+ LR E + + E V
Sbjct: 780 LLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRER 839
Query: 333 ------TPDTVANASGPLM---VEIVKTPGSALGISL-----TTTSLRNKSVITIDRIKP 378
P + GPL V + LG S+ +T + I + RI
Sbjct: 840 RGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAE 899
Query: 379 ASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQ 438
R+G L GD +LSI+G + A LL + S + L L ++ PL P
Sbjct: 900 GGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL--LLEREAGGPLPPS 957
Query: 439 RQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHA 498
P HS P T T A + + P +P+L A
Sbjct: 958 -------------------PLPHSSPPTAAVATTSITTA----TPGVPGLPSLAPSLLAA 994
Query: 499 FSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLC 558
G P+ + R ++ L S VG H
Sbjct: 995 --------ALEGPYPV----------EEIRLPRAGGPLGLSIVGGSDHSSHP-------- 1028
Query: 559 GDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGT 618
FG+Q + G+F ++ L P A R G L+VGDR+L++NG D T
Sbjct: 1029 ------FGVQ-EPGVFISKVL----------PRGLAARSG-LRVGDRILAVNGQDVRDAT 1070
Query: 619 MEEA-NQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKR 677
+EA + LLR LE+ V P G + + K LGI+I +R
Sbjct: 1071 HQEAVSALLRPC-------LELSLLVRRDPAP-PGLRELCIQKAPGERLGISIRGGARGH 1122
Query: 678 G--------EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCED 729
E + IS + A R G L G +LL ++ L +AVQ+LR D
Sbjct: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
Query: 730 LVKLKI 735
+ + +
Sbjct: 1183 TLTVLV 1188
Score = 74.3 bits (181), Expect = 6e-13
Identities = 96/368 (26%), Positives = 145/368 (39%), Gaps = 58/368 (15%)
Query: 149 IKKEGSTLGLTISGGTDKDGKPR--------VSNLRPGGLAARSDLLNIGDYIRSVNGIH 200
+ + G LGL+I GG+D P +S + P GLAARS L +GD I +VNG
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGL-RVGDRILAVNGQD 1065
Query: 201 LTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLR 260
+ H E ++ L + L V + PP I K G G +R
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE--LCIQKA-------PGERLGISIR 1116
Query: 261 GGAHEDGHKSRP-------LVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATAL 313
GGA GH P + ++ V P G A R+G L+VG RLL V+ L G +H A+
Sbjct: 1117 GGAR--GHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAV 1174
Query: 314 ATLRQCSHEALFQV--EYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVI 371
LR V ++ +T + + G ++ P +A GI + +S+
Sbjct: 1175 QLLRSVGDTLTVLVCDGFEASTDAALEVSPG-----VIANPFAA-GIGHRNSL---ESIS 1225
Query: 372 TIDR----IKPASVVDRSG-ALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEIL 426
+IDR P + G LH G G ++ L + LA++ ++ +
Sbjct: 1226 SIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKL--DYRALAAVPSAGSVQRV 1283
Query: 427 P-------------VPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTW 473
P P Q+P P +Q +R VP+ H P + PT
Sbjct: 1284 PSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTP 1343
Query: 474 ATPAGQDQ 481
A +Q
Sbjct: 1344 GPAASPEQ 1351
Score = 68.6 bits (166), Expect = 3e-11
Identities = 89/379 (23%), Positives = 150/379 (39%), Gaps = 92/379 (24%)
Query: 149 IKKEGSTLGLTISGGTDK------DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLT 202
I ++ LG++I+GG D +S + G AAR+ + +GD + VNG+ L
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGV-RVGDKLLEVNGVALQ 789
Query: 203 RLRHDEIITLLKNVGERVVLEVEYE----------LPPPAPEN----------------- 235
H E + L+ G V + V E + P PE+
Sbjct: 790 GAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLL 849
Query: 236 ---NPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKS--RPLVLTYVRPGGPADREGSL 290
+P + + L + GF + GG +++ + ++ + GG A R G+L
Sbjct: 850 PPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTL 909
Query: 291 KVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDV-----------ATPDTVAN 339
+VGDR+LS++G+ + A H A++ L S +E + ++P T A
Sbjct: 910 QVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAV 969
Query: 340 AS--------------------------GPLMVEIVKTP--GSALGISLTTTSLRN---- 367
A+ GP VE ++ P G LG+S+ S +
Sbjct: 970 ATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPF 1029
Query: 368 ---KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLL----ASISEK 420
+ + I ++ P + RSG L GD IL+++G + + EA L +S
Sbjct: 1030 GVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLL 1088
Query: 421 VRLEILPVPQSQRPLRPQR 439
VR + P P R L Q+
Sbjct: 1089 VRRD--PAPPGLRELCIQK 1105
Score = 63.2 bits (152), Expect = 1e-09
Identities = 68/273 (24%), Positives = 109/273 (39%), Gaps = 54/273 (19%)
Query: 667 GITISSASRKRGEP-------LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMED 719
G+ IS A K P + IS + + A R G + GDKLL ++ + L +
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795
Query: 720 AVQILRQCEDLVKLKI-----------------RKDEDNSDELETTGAVSYTVELKRYGG 762
AV+ LR V++++ R ++D S G + + G
Sbjct: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPG 855
Query: 763 PL---------------GITISGTE--EPFDP----IVISGLTKRGLAERTGAIHVGDRI 801
PL G +I+G + P+ I +S + + G A R G + VGDR+
Sbjct: 856 PLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRV 915
Query: 802 LAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADA 861
L+IN V + A+ LL A T+ L ++++ PL P L +S P A
Sbjct: 916 LSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPP---SPLPHSS-----PPTA 967
Query: 862 LKGGLPAARFSPAVPSVDSAVESWDSSATEGGF 894
+P VP + S S ++A EG +
Sbjct: 968 AVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
Score = 45.8 bits (107), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 12/108 (11%)
Query: 126 DVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGT-DKDGKPR--------VSNLR 176
++SL RR P R + + K G LG++I GG G PR +S +
Sbjct: 1084 ELSLLVRRDPAPPGLRELCIQ---KAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140
Query: 177 PGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV 224
P G A R L +G + VN L L H E + LL++VG+ + + V
Sbjct: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 42.0 bits (97), Expect = 0.003
Identities = 58/251 (23%), Positives = 96/251 (38%), Gaps = 55/251 (21%)
Query: 904 AAARGTTPQERRP----GWLRGSPPPTEPRRTSYTPTPADESFPEEEEEDDWEPPTSPAP 959
A +G P P GW G P PR +E P+EEEE++ E +
Sbjct: 627 ALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQK-EEEEEEEGSPQEEEEEEEEENRAEEE 685
Query: 960 GPAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGTVQRVALEGRPGHRPWQRGREV 1019
+ EE ED E A + +V+ V+ + + +
Sbjct: 686 EASTEE----------EDKEG-----------AVVSAPSVKGVSFD---------QANNL 715
Query: 1020 RASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLL-------EKGVYVHTVRPD 1072
PA +EE ++TL G S++ G ++G+++ V +
Sbjct: 716 LIEPARIEE---------EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
Query: 1073 GPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISR----KPHTAHSSR 1128
GPA R G++ D++L+VN V + + AV L AG +++ + R +P A +
Sbjct: 767 GPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTIT 826
Query: 1129 APRSPGPSSPR 1139
R SPR
Sbjct: 827 PLRPEDDYSPR 837
Score = 40.4 bits (93), Expect = 0.010
Identities = 35/102 (34%), Positives = 45/102 (44%), Gaps = 10/102 (9%)
Query: 1023 PAEMEELLLPT---PLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGG 1079
P +EE+ LP PL + + D H FG E GV++ V P G A R G
Sbjct: 999 PYPVEEIRLPRAGGPLGL-SIVGGSDHSSHPFGVQ------EPGVFISKVLPRGLAARSG 1051
Query: 1080 LQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKP 1121
L+ DR+L VN RD AV L L L++ R P
Sbjct: 1052 LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
Score = 38.9 bits (89), Expect = 0.028
Identities = 36/114 (31%), Positives = 48/114 (42%), Gaps = 13/114 (11%)
Query: 1032 PTPLEMHKVTLHKDPMRHDFGFSVSDG-------LLEKGVYVHTVRPDGPAHRGG-LQPF 1083
P PL V R GFS++ G + G++V + G AHR G LQ
Sbjct: 854 PGPLRQRHVACLARSER-GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 1084 DRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSPGPSS 1137
DRVL +N V + AV LL A + L++ R+ P SP P S
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREA----GGPLPPSPLPHS 962
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 87.4 bits (215), Expect = 7e-17
Identities = 84/332 (25%), Positives = 134/332 (40%), Gaps = 68/332 (20%)
Query: 149 IKKEGSTLGLTISGGTDK-----DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTR 203
+++ S LG +I+GGTD D ++ + PGG AA+ L + D I VN + +
Sbjct: 111 LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 170
Query: 204 LRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGA 263
+ H + LK G V L V PP K +++ L K GF + GG
Sbjct: 171 VTHSAAVEALKEAGSIVRLYVMRRKPPA---------EKVMEIKLIKGPKGLGFSIAGGV 221
Query: 264 ---HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
H G S + +T + GG A ++G L++GD++L+V+ + L H A+A L+
Sbjct: 222 GNQHIPGDNS--IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTY 279
Query: 321 HEALFQV--------EYDVATPDTVANASGPLMVEIVKTP--GSALGISLTTTSLRNKSV 370
+V A PD + S L EI + G+ ++T TS R S
Sbjct: 280 DVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSP 339
Query: 371 ITIDRI-------KPASVV--------------------------------DRSGALHPG 391
+ D + +P +V D SG L G
Sbjct: 340 VAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKG 399
Query: 392 DHILSIDGTSMEHCSLLEATKLLASISEKVRL 423
D ILS++G + + S +A L + + V +
Sbjct: 400 DQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431
Score = 79.7 bits (195), Expect = 1e-14
Identities = 77/319 (24%), Positives = 132/319 (41%), Gaps = 54/319 (16%)
Query: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
SG G + GG P + + I P A + G L+V D +L +N + + T
Sbjct: 116 SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175
Query: 622 ANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPL 681
A + L++A ++ + AE V+ +K PK + + + +
Sbjct: 176 AVEALKEAGSIVRLYVMRRKPPAEKVMEIK---LIKGPKGLGFSIAGGVGNQHIPGDNSI 232
Query: 682 IISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED- 740
++ I +G AH+ G L+ GDK+LA++++ L++ EDAV L+ D+V LK+ K +
Sbjct: 233 YVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNA 292
Query: 741 ------------------------NSDELETTGAVSYTVELKRYGGPLGITISGTEE-PF 775
+S L T + T R P+ + G E+ P
Sbjct: 293 YLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR 352
Query: 776 DP------------------------IVISGLTKRGLAERTGAIHVGDRILAINNVSLKG 811
+P I IS + G A+ +G + GD+IL++N V L+
Sbjct: 353 EPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 412
Query: 812 RPLSEAIHLLQVAGETVTL 830
+A L+ AG+TVT+
Sbjct: 413 ASHEQAAIALKNAGQTVTI 431
Score = 70.1 bits (170), Expect = 1e-11
Identities = 78/342 (22%), Positives = 132/342 (38%), Gaps = 75/342 (21%)
Query: 124 GADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDK-----DGKPRVSNLRPG 178
G+ V L R+ P E + ++LIK LG +I+GG D V+ + G
Sbjct: 184 GSIVRLYVMRRKPPAE--KVMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEG 240
Query: 179 GLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEY------------ 226
G A + L IGD I +VN + L + H++ + LKN + V L+V
Sbjct: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
Query: 227 -----------------------ELPPPAPENNPRIISKTVD--------------VSLY 249
+ P +PR S + ++
Sbjct: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
Query: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309
+ GF + GG +G + ++++ GGPAD G L+ GD++LSV+G+ L ASH
Sbjct: 361 RGSTGLGFNIVGGEDGEG-----IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASH 415
Query: 310 ATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRN-- 367
A L+ +Y P+ + + + S+LG T SLR+
Sbjct: 416 EQAAIALKNAGQTVTIIAQY---KPEEYSRFEAKIHDLREQLMNSSLGSG--TASLRSNP 470
Query: 368 ------KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSME 403
+++ D+ K + ++ + GD + ID + E
Sbjct: 471 KRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEE 512
Score = 59.7 bits (143), Expect = 2e-08
Identities = 79/399 (19%), Positives = 147/399 (36%), Gaps = 77/399 (19%)
Query: 245 DVSLYKEGNSFGFVLRGGAHEDGHKSRPLV-LTYVRPGGPADREGSLKVGDRLLSVDGIP 303
+++L + + GF + GG P + +T + PGG A ++G L+V D +L V+ +
Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167
Query: 304 LHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLT-- 361
+ +H+ A+ L++ V + V + ++++K P LG S+
Sbjct: 168 VREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKV------MEIKLIKGP-KGLGFSIAGG 220
Query: 362 --TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISE 419
+ + I + +I + G L GD IL+++ +E +A L + +
Sbjct: 221 VGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYD 280
Query: 420 KVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQ 479
V L KV + + D P P T Q
Sbjct: 281 VVYL-------------------KVAKPSNAYLSDSYAP------------PDITTSYSQ 309
Query: 480 DQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASS 539
+S + + A + +P ++ + + R +R H+ S L
Sbjct: 310 HLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGL--- 366
Query: 540 TVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGL 599
G IV E E GIF + FI PA+ G
Sbjct: 367 ----GFNIVGGEDGE-----------------GIF----------ISFILAGGPADLSGE 395
Query: 600 LQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLE 638
L+ GD++LS+NG+ + + E+A L++A ++ +
Sbjct: 396 LRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Score = 55.8 bits (133), Expect = 2e-07
Identities = 41/161 (25%), Positives = 81/161 (50%), Gaps = 16/161 (9%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED 740
+ I+ I G A + G L D +L ++ + + AV+ L++ +V+L + + +
Sbjct: 137 IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP 196
Query: 741 NSDELETTGAVSYTVELKRYGGP--LGITISG----TEEPFD-PIVISGLTKRGLAERTG 793
++++ +E+K GP LG +I+G P D I ++ + + G A + G
Sbjct: 197 PAEKV---------MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 247
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ +GD+ILA+N+V L+ +A+ L+ + V LK+ K
Sbjct: 248 RLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK 288
Score = 37.4 bits (85), Expect = 0.082
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 3/89 (3%)
Query: 1034 PLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHV 1092
P E ++ +H+ GF++ G +G+++ + GPA G L+ D++L VN V
Sbjct: 351 PREPRRIVIHRGST--GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGV 408
Query: 1093 RTRDFDCCLAVPLLAEAGDVLELIISRKP 1121
R+ A L AG + +I KP
Sbjct: 409 DLRNASHEQAAIALKNAGQTVTIIAQYKP 437
Score = 33.9 bits (76), Expect = 0.91
Identities = 33/109 (30%), Positives = 51/109 (46%), Gaps = 10/109 (9%)
Query: 1032 PTPLEMHKVTLHKDPMRHDFGFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFD 1084
P ++ ++ L K P GFS++ G+ + +YV + G AH+ G LQ D
Sbjct: 196 PPAEKVMEIKLIKGPK--GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGD 253
Query: 1085 RVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSP 1133
++L VN V D AV L DV+ L ++ KP A+ S + P
Sbjct: 254 KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVA-KPSNAYLSDSYAPP 301
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 87.4 bits (215), Expect = 7e-17
Identities = 84/332 (25%), Positives = 134/332 (40%), Gaps = 68/332 (20%)
Query: 149 IKKEGSTLGLTISGGTDK-----DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTR 203
+++ S LG +I+GGTD D ++ + PGG AA+ L + D I VN + +
Sbjct: 65 LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 124
Query: 204 LRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGA 263
+ H + LK G V L V PP K +++ L K GF + GG
Sbjct: 125 VTHSAAVEALKEAGSIVRLYVMRRKPPA---------EKVMEIKLIKGPKGLGFSIAGGV 175
Query: 264 ---HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
H G S + +T + GG A ++G L++GD++L+V+ + L H A+A L+
Sbjct: 176 GNQHIPGDNS--IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTY 233
Query: 321 HEALFQV--------EYDVATPDTVANASGPLMVEIVKTP--GSALGISLTTTSLRNKSV 370
+V A PD + S L EI + G+ ++T TS R S
Sbjct: 234 DVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSP 293
Query: 371 ITIDRI-------KPASVV--------------------------------DRSGALHPG 391
+ D + +P +V D SG L G
Sbjct: 294 VAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKG 353
Query: 392 DHILSIDGTSMEHCSLLEATKLLASISEKVRL 423
D ILS++G + + S +A L + + V +
Sbjct: 354 DQILSVNGVDLRNASHEQAAIALKNAGQTVTI 385
Score = 79.7 bits (195), Expect = 1e-14
Identities = 77/319 (24%), Positives = 132/319 (41%), Gaps = 54/319 (16%)
Query: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
SG G + GG P + + I P A + G L+V D +L +N + + T
Sbjct: 70 SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129
Query: 622 ANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPL 681
A + L++A ++ + AE V+ +K PK + + + +
Sbjct: 130 AVEALKEAGSIVRLYVMRRKPPAEKVMEIK---LIKGPKGLGFSIAGGVGNQHIPGDNSI 186
Query: 682 IISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED- 740
++ I +G AH+ G L+ GDK+LA++++ L++ EDAV L+ D+V LK+ K +
Sbjct: 187 YVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNA 246
Query: 741 ------------------------NSDELETTGAVSYTVELKRYGGPLGITISGTEE-PF 775
+S L T + T R P+ + G E+ P
Sbjct: 247 YLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR 306
Query: 776 DP------------------------IVISGLTKRGLAERTGAIHVGDRILAINNVSLKG 811
+P I IS + G A+ +G + GD+IL++N V L+
Sbjct: 307 EPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 366
Query: 812 RPLSEAIHLLQVAGETVTL 830
+A L+ AG+TVT+
Sbjct: 367 ASHEQAAIALKNAGQTVTI 385
Score = 70.1 bits (170), Expect = 1e-11
Identities = 78/342 (22%), Positives = 132/342 (38%), Gaps = 75/342 (21%)
Query: 124 GADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDK-----DGKPRVSNLRPG 178
G+ V L R+ P E + ++LIK LG +I+GG D V+ + G
Sbjct: 138 GSIVRLYVMRRKPPAE--KVMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEG 194
Query: 179 GLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEY------------ 226
G A + L IGD I +VN + L + H++ + LKN + V L+V
Sbjct: 195 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254
Query: 227 -----------------------ELPPPAPENNPRIISKTVD--------------VSLY 249
+ P +PR S + ++
Sbjct: 255 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314
Query: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309
+ GF + GG +G + ++++ GGPAD G L+ GD++LSV+G+ L ASH
Sbjct: 315 RGSTGLGFNIVGGEDGEG-----IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASH 369
Query: 310 ATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRN-- 367
A L+ +Y P+ + + + S+LG T SLR+
Sbjct: 370 EQAAIALKNAGQTVTIIAQY---KPEEYSRFEAKIHDLREQLMNSSLGSG--TASLRSNP 424
Query: 368 ------KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSME 403
+++ D+ K + ++ + GD + ID + E
Sbjct: 425 KRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEE 466
Score = 59.7 bits (143), Expect = 2e-08
Identities = 79/399 (19%), Positives = 147/399 (36%), Gaps = 77/399 (19%)
Query: 245 DVSLYKEGNSFGFVLRGGAHEDGHKSRPLV-LTYVRPGGPADREGSLKVGDRLLSVDGIP 303
+++L + + GF + GG P + +T + PGG A ++G L+V D +L V+ +
Sbjct: 62 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121
Query: 304 LHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLT-- 361
+ +H+ A+ L++ V + V + ++++K P LG S+
Sbjct: 122 VREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKV------MEIKLIKGP-KGLGFSIAGG 174
Query: 362 --TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISE 419
+ + I + +I + G L GD IL+++ +E +A L + +
Sbjct: 175 VGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYD 234
Query: 420 KVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQ 479
V L KV + + D P P T Q
Sbjct: 235 VVYL-------------------KVAKPSNAYLSDSYAP------------PDITTSYSQ 263
Query: 480 DQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASS 539
+S + + A + +P ++ + + R +R H+ S L
Sbjct: 264 HLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGL--- 320
Query: 540 TVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGL 599
G IV E E GIF + FI PA+ G
Sbjct: 321 ----GFNIVGGEDGE-----------------GIF----------ISFILAGGPADLSGE 349
Query: 600 LQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLE 638
L+ GD++LS+NG+ + + E+A L++A ++ +
Sbjct: 350 LRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
Score = 55.8 bits (133), Expect = 2e-07
Identities = 41/161 (25%), Positives = 81/161 (50%), Gaps = 16/161 (9%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED 740
+ I+ I G A + G L D +L ++ + + AV+ L++ +V+L + + +
Sbjct: 91 IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP 150
Query: 741 NSDELETTGAVSYTVELKRYGGP--LGITISG----TEEPFD-PIVISGLTKRGLAERTG 793
++++ +E+K GP LG +I+G P D I ++ + + G A + G
Sbjct: 151 PAEKV---------MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 201
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ +GD+ILA+N+V L+ +A+ L+ + V LK+ K
Sbjct: 202 RLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK 242
Score = 37.4 bits (85), Expect = 0.082
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 3/89 (3%)
Query: 1034 PLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHV 1092
P E ++ +H+ GF++ G +G+++ + GPA G L+ D++L VN V
Sbjct: 305 PREPRRIVIHRGST--GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGV 362
Query: 1093 RTRDFDCCLAVPLLAEAGDVLELIISRKP 1121
R+ A L AG + +I KP
Sbjct: 363 DLRNASHEQAAIALKNAGQTVTIIAQYKP 391
Score = 33.9 bits (76), Expect = 0.91
Identities = 33/109 (30%), Positives = 51/109 (46%), Gaps = 10/109 (9%)
Query: 1032 PTPLEMHKVTLHKDPMRHDFGFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFD 1084
P ++ ++ L K P GFS++ G+ + +YV + G AH+ G LQ D
Sbjct: 150 PPAEKVMEIKLIKGPK--GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGD 207
Query: 1085 RVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSP 1133
++L VN V D AV L DV+ L ++ KP A+ S + P
Sbjct: 208 KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVA-KPSNAYLSDSYAPP 255
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 86.3 bits (212), Expect = 2e-16
Identities = 63/200 (31%), Positives = 94/200 (47%), Gaps = 23/200 (11%)
Query: 136 IPEEFRGITVVELIKKEGSTLGLTISGGTDK-----DGKPRVSNLRPGGLAARSDLLNIG 190
I EF IT +++ S LG +I+GGTD D ++ + PGG AA L +
Sbjct: 41 IEYEFEEIT----LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 96
Query: 191 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYK 250
D I VN + ++ + H + + LK G V L V P I+ V++ L+K
Sbjct: 97 DCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP---------ILETVVEIKLFK 147
Query: 251 EGNSFGFVLRGGA---HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGA 307
GF + GG H G S + +T + GG A ++G L+VGDRLL V+ L
Sbjct: 148 GPKGLGFSIAGGVGNQHIPGDNS--IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 205
Query: 308 SHATALATLRQCSHEALFQV 327
+H A+A L+ S +V
Sbjct: 206 THEEAVAILKNTSEVVYLKV 225
Score = 78.6 bits (192), Expect = 3e-14
Identities = 107/482 (22%), Positives = 181/482 (37%), Gaps = 71/482 (14%)
Query: 233 PENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRP-LVLTYVRPGGPADREGSLK 291
P N I + +++L + + GF + GG P + +T + PGG A +G L+
Sbjct: 35 PVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLR 94
Query: 292 VGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKT 351
V D +L V+ + + SH+ A+ L++ V +TV +++ K
Sbjct: 95 VNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVE------IKLFKG 148
Query: 352 PGSALGISLT----TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSL 407
P LG S+ + + I + +I + G L GD +L ++ S+E +
Sbjct: 149 P-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTH 207
Query: 408 LEATKLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGH 467
EA +L + SE V L KV + ++ DP P P H
Sbjct: 208 EEAVAILKNTSEVVYL-------------------KVGKPTTIYMTDPYGP----PDITH 244
Query: 468 CRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRR 527
P + +L P S S +P+ T+ +
Sbjct: 245 SYSPPMENHLLSGNNGTLEYKTSLPP-----ISPGRYSPIPKHMLVDDDYTSHSQHSTAT 299
Query: 528 REHKSSLSLASSTVG-PGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVC 586
R+ +L A S G P ++H +T G G + GG V
Sbjct: 300 RQPSMTLQRAVSLEGEPRKVVLHKGST----------GLGFNIVGG-----EDGEGIFVS 344
Query: 587 FIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVE------ 640
FI PA+ G LQ GD++LS+NGI + E+A L+ A ++ + +
Sbjct: 345 FILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYAR 404
Query: 641 -----FDVAESVI---PSSGTFHVKLPKKRSVELGITIS-SASRKRGEPLIISDIKKGSV 691
D+ E ++ SSG+ ++ +KRS+ + S+ G P K G +
Sbjct: 405 FEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDI 464
Query: 692 AH 693
H
Sbjct: 465 LH 466
Score = 70.5 bits (171), Expect = 9e-12
Identities = 96/400 (24%), Positives = 153/400 (38%), Gaps = 87/400 (21%)
Query: 120 KDAGGADVSLACRRQSIPEEFRGITVVEL-IKKEGSTLGLTISGGTDK-----DGKPRVS 173
K+AG RR+ I E TVVE+ + K LG +I+GG D V+
Sbjct: 120 KEAGSIVRLYVRRRRPILE-----TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVT 174
Query: 174 NLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV--------- 224
+ GG A + L +GD + VN L + H+E + +LKN E V L+V
Sbjct: 175 KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMT 234
Query: 225 ----------------------------EYE--LPPPAP--------------------- 233
EY+ LPP +P
Sbjct: 235 DPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQ 294
Query: 234 -ENNPRIISKTVDVSLYKEGNSFGFVLRGGAH------EDGHKSRPLVLTYVRPGGPADR 286
R S T+ ++ EG VL G+ G + ++++ GGPAD
Sbjct: 295 HSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADL 354
Query: 287 EGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEY---DVATPDTVANASGP 343
G L+ GD++LSV+GI L GASH A A L+ +Y D A + +
Sbjct: 355 SGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLRE 414
Query: 344 LMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSME 403
M+ + GS + SL +++ D+ K + + + + GD + I+ + E
Sbjct: 415 QMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDE 474
Query: 404 HCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQRQVVK 443
+L SE++ + +P +R R +R +K
Sbjct: 475 WWQARRV--MLEGDSEEMGV----IPSKRRVERKERARLK 508
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/161 (30%), Positives = 80/161 (49%), Gaps = 16/161 (9%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED 740
+ I+ I G A G L D +L ++ + + AV+ L++ +V+L +R+
Sbjct: 76 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR--- 132
Query: 741 NSDELETTGAVSYTVELKRYGGP--LGITISG----TEEPFD-PIVISGLTKRGLAERTG 793
LET VE+K + GP LG +I+G P D I ++ + G A++ G
Sbjct: 133 RRPILETV------VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDG 186
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ VGDR+L +NN SL+ EA+ +L+ E V LK+ K
Sbjct: 187 RLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 227
Score = 58.9 bits (141), Expect = 3e-08
Identities = 47/180 (26%), Positives = 84/180 (46%), Gaps = 12/180 (6%)
Query: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
SG G + GG P + + I P A G L+V D +L +N + + + +
Sbjct: 55 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 114
Query: 622 ANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEP- 680
A + L++A ++ + + E+V+ +KL K LG +I+ + P
Sbjct: 115 AVEALKEAGSIVRLYVRRRRPILETVV------EIKLFKGPK-GLGFSIAGGVGNQHIPG 167
Query: 681 ---LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK 737
+ ++ I G A + G L+ GD+LL ++N L+ E+AV IL+ ++V LK+ K
Sbjct: 168 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 227
Score = 53.1 bits (126), Expect = 1e-06
Identities = 68/277 (24%), Positives = 107/277 (38%), Gaps = 44/277 (15%)
Query: 564 GFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622
G G + GG+ + V I A++ G LQVGDR+L +N + E+ T EEA
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210
Query: 623 NQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLI 682
+L++ +S ++K+ K ++ + + G P I
Sbjct: 211 VAILKN---------------------TSEVVYLKVGKPTTIYM-------TDPYGPPDI 242
Query: 683 ISDIKKGSVAH----RTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKD 738
H GTLE L I R P V +D
Sbjct: 243 THSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVD-----DDYTSHSQHST 297
Query: 739 EDNSDELETTGAVSYTVE-----LKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTG 793
+ AVS E L + LG I G E+ + I +S + G A+ +G
Sbjct: 298 ATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-EGIFVSFILAGGPADLSG 356
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTL 830
+ GD+IL++N + L+G +A L+ AG+TVT+
Sbjct: 357 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
Score = 37.7 bits (86), Expect = 0.063
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 3/87 (3%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRT 1094
E KV LHK GF++ G +G++V + GPA G LQ D++L VN +
Sbjct: 315 EPRKVVLHKGST--GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 372
Query: 1095 RDFDCCLAVPLLAEAGDVLELIISRKP 1121
R A L AG + +I +P
Sbjct: 373 RGASHEQAAAALKGAGQTVTIIAQYQP 399
Score = 36.6 bits (83), Expect = 0.14
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFDRVLQ 1088
E ++TL + GFS++ G + G+++ + P G A G L+ D +L+
Sbjct: 44 EFEEITLERG--NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 101
Query: 1089 VNHVRTRDFDCCLAVPLLAEAGDVLELIISRK 1120
VN V + AV L EAG ++ L + R+
Sbjct: 102 VNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 133
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 86.3 bits (212), Expect = 2e-16
Identities = 63/200 (31%), Positives = 94/200 (47%), Gaps = 23/200 (11%)
Query: 136 IPEEFRGITVVELIKKEGSTLGLTISGGTDK-----DGKPRVSNLRPGGLAARSDLLNIG 190
I EF IT +++ S LG +I+GGTD D ++ + PGG AA L +
Sbjct: 197 IEYEFEEIT----LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 252
Query: 191 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYK 250
D I VN + ++ + H + + LK G V L V P I+ V++ L+K
Sbjct: 253 DCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP---------ILETVVEIKLFK 303
Query: 251 EGNSFGFVLRGGA---HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGA 307
GF + GG H G S + +T + GG A ++G L+VGDRLL V+ L
Sbjct: 304 GPKGLGFSIAGGVGNQHIPGDNS--IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 361
Query: 308 SHATALATLRQCSHEALFQV 327
+H A+A L+ S +V
Sbjct: 362 THEEAVAILKNTSEVVYLKV 381
Score = 79.3 bits (194), Expect = 2e-14
Identities = 112/505 (22%), Positives = 194/505 (38%), Gaps = 69/505 (13%)
Query: 235 NNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRP-LVLTYVRPGGPADREGSLKVG 293
N I + +++L + + GF + GG P + +T + PGG A +G L+V
Sbjct: 193 NGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 252
Query: 294 DRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPG 353
D +L V+ + + SH+ A+ L++ V +TV +++ K P
Sbjct: 253 DCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVE------IKLFKGP- 305
Query: 354 SALGISLT----TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLE 409
LG S+ + + I + +I + G L GD +L ++ S+E + E
Sbjct: 306 KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 365
Query: 410 ATKLLASISEKVRLEI-----------LPVPQSQRPLRPQRQVVKVQRS----EQLHRWD 454
A +L + SE V L++ P P + + + E
Sbjct: 366 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLP 425
Query: 455 PCVPSCHSPRPGHCRM---------PTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNP- 504
P P +SP P H + P ++T + + S +S + +F + P
Sbjct: 426 PISPGRYSPIPKHMLVDDDYTRPPEPVYST-VNKLCDKPASPRHYSPVECDKSFLLSAPY 484
Query: 505 STLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVG-PGGQIVHTETTEVVLCGDPLS 563
S G P S T+ + R+ +L A S G P ++H +T
Sbjct: 485 SHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST---------- 534
Query: 564 GFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEAN 623
G G + GG V FI PA+ G LQ GD++LS+NGI + E+A
Sbjct: 535 GLGFNIVGG-----EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAA 589
Query: 624 QLLRDAALAHKVVLEVE-----------FDVAESVI---PSSGTFHVKLPKKRSVELGIT 669
L+ A ++ + + D+ E ++ SSG+ ++ +KRS+ +
Sbjct: 590 AALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAM 649
Query: 670 IS-SASRKRGEPLIISDIKKGSVAH 693
S+ G P K G + H
Sbjct: 650 FDYDKSKDSGLPSQGLSFKYGDILH 674
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/161 (30%), Positives = 80/161 (49%), Gaps = 16/161 (9%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED 740
+ I+ I G A G L D +L ++ + + AV+ L++ +V+L +R+
Sbjct: 232 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR--- 288
Query: 741 NSDELETTGAVSYTVELKRYGGP--LGITISG----TEEPFD-PIVISGLTKRGLAERTG 793
LET VE+K + GP LG +I+G P D I ++ + G A++ G
Sbjct: 289 RRPILETV------VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDG 342
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ VGDR+L +NN SL+ EA+ +L+ E V LK+ K
Sbjct: 343 RLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 58.9 bits (141), Expect = 3e-08
Identities = 47/180 (26%), Positives = 84/180 (46%), Gaps = 12/180 (6%)
Query: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
SG G + GG P + + I P A G L+V D +L +N + + + +
Sbjct: 211 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 270
Query: 622 ANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEP- 680
A + L++A ++ + + E+V+ +KL K LG +I+ + P
Sbjct: 271 AVEALKEAGSIVRLYVRRRRPILETVV------EIKLFKGPK-GLGFSIAGGVGNQHIPG 323
Query: 681 ---LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK 737
+ ++ I G A + G L+ GD+LL ++N L+ E+AV IL+ ++V LK+ K
Sbjct: 324 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 57.4 bits (137), Expect = 8e-08
Identities = 52/201 (25%), Positives = 90/201 (44%), Gaps = 14/201 (6%)
Query: 246 VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLH 305
V L+K GF + GG +G + ++++ GGPAD G L+ GD++LSV+GI L
Sbjct: 527 VVLHKGSTGLGFNIVGGEDGEG-----IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581
Query: 306 GASHATALATLRQCSHEALFQVEY---DVATPDTVANASGPLMVEIVKTPGSALGISLTT 362
GASH A A L+ +Y D A + + M+ + GS +
Sbjct: 582 GASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQK 641
Query: 363 TSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVR 422
SL +++ D+ K + + + + GD + I+ + E +L SE++
Sbjct: 642 RSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV--MLEGDSEEMG 699
Query: 423 LEILPVPQSQRPLRPQRQVVK 443
+ +P +R R +R +K
Sbjct: 700 V----IPSKRRVERKERARLK 716
Score = 49.3 bits (116), Expect = 2e-05
Identities = 37/101 (36%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 147 ELIKKEGST-LGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLR 205
+++ +GST LG I GG D +G VS + GG A S L GD I SVNGI L
Sbjct: 526 KVVLHKGSTGLGFNIVGGEDGEGI-FVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584
Query: 206 HDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDV 246
H++ LK G+ V + +Y+ PE+ R +K D+
Sbjct: 585 HEQAAAALKGAGQTVTIIAQYQ-----PEDYARFEAKIHDL 620
Score = 48.1 bits (113), Expect = 5e-05
Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 11/111 (9%)
Query: 120 KDAGGADVSLACRRQSIPEEFRGITVVEL-IKKEGSTLGLTISGGTDK-----DGKPRVS 173
K+AG RR+ I E TVVE+ + K LG +I+GG D V+
Sbjct: 276 KEAGSIVRLYVRRRRPILE-----TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVT 330
Query: 174 NLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV 224
+ GG A + L +GD + VN L + H+E + +LKN E V L+V
Sbjct: 331 KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 1/67 (1%)
Query: 764 LGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQV 823
LG I G E+ + I +S + G A+ +G + GD+IL++N + L+G +A L+
Sbjct: 536 LGFNIVGGEDG-EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594
Query: 824 AGETVTL 830
AG+TVT+
Sbjct: 595 AGQTVTI 601
Score = 36.6 bits (83), Expect = 0.14
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFDRVLQ 1088
E ++TL + GFS++ G + G+++ + P G A G L+ D +L+
Sbjct: 200 EFEEITLERG--NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 257
Query: 1089 VNHVRTRDFDCCLAVPLLAEAGDVLELIISRK 1120
VN V + AV L EAG ++ L + R+
Sbjct: 258 VNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 289
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 86.3 bits (212), Expect = 2e-16
Identities = 63/200 (31%), Positives = 94/200 (47%), Gaps = 23/200 (11%)
Query: 136 IPEEFRGITVVELIKKEGSTLGLTISGGTDK-----DGKPRVSNLRPGGLAARSDLLNIG 190
I EF IT +++ S LG +I+GGTD D ++ + PGG AA L +
Sbjct: 92 IEYEFEEIT----LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 147
Query: 191 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYK 250
D I VN + ++ + H + + LK G V L V P I+ V++ L+K
Sbjct: 148 DCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP---------ILETVVEIKLFK 198
Query: 251 EGNSFGFVLRGGA---HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGA 307
GF + GG H G S + +T + GG A ++G L+VGDRLL V+ L
Sbjct: 199 GPKGLGFSIAGGVGNQHIPGDNS--IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 256
Query: 308 SHATALATLRQCSHEALFQV 327
+H A+A L+ S +V
Sbjct: 257 THEEAVAILKNTSEVVYLKV 276
Score = 79.3 bits (194), Expect = 2e-14
Identities = 112/505 (22%), Positives = 194/505 (38%), Gaps = 69/505 (13%)
Query: 235 NNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRP-LVLTYVRPGGPADREGSLKVG 293
N I + +++L + + GF + GG P + +T + PGG A +G L+V
Sbjct: 88 NGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 147
Query: 294 DRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPG 353
D +L V+ + + SH+ A+ L++ V +TV +++ K P
Sbjct: 148 DCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVE------IKLFKGP- 200
Query: 354 SALGISLT----TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLE 409
LG S+ + + I + +I + G L GD +L ++ S+E + E
Sbjct: 201 KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 260
Query: 410 ATKLLASISEKVRLEI-----------LPVPQSQRPLRPQRQVVKVQRS----EQLHRWD 454
A +L + SE V L++ P P + + + E
Sbjct: 261 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLP 320
Query: 455 PCVPSCHSPRPGHCRM---------PTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNP- 504
P P +SP P H + P ++T + + S +S + +F + P
Sbjct: 321 PISPGRYSPIPKHMLVDDDYTRPPEPVYST-VNKLCDKPASPRHYSPVECDKSFLLSAPY 379
Query: 505 STLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVG-PGGQIVHTETTEVVLCGDPLS 563
S G P S T+ + R+ +L A S G P ++H +T
Sbjct: 380 SHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST---------- 429
Query: 564 GFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEAN 623
G G + GG V FI PA+ G LQ GD++LS+NGI + E+A
Sbjct: 430 GLGFNIVGG-----EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAA 484
Query: 624 QLLRDAALAHKVVLEVE-----------FDVAESVI---PSSGTFHVKLPKKRSVELGIT 669
L+ A ++ + + D+ E ++ SSG+ ++ +KRS+ +
Sbjct: 485 AALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAM 544
Query: 670 IS-SASRKRGEPLIISDIKKGSVAH 693
S+ G P K G + H
Sbjct: 545 FDYDKSKDSGLPSQGLSFKYGDILH 569
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/161 (30%), Positives = 80/161 (49%), Gaps = 16/161 (9%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED 740
+ I+ I G A G L D +L ++ + + AV+ L++ +V+L +R+
Sbjct: 127 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR--- 183
Query: 741 NSDELETTGAVSYTVELKRYGGP--LGITISG----TEEPFD-PIVISGLTKRGLAERTG 793
LET VE+K + GP LG +I+G P D I ++ + G A++ G
Sbjct: 184 RRPILETV------VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDG 237
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ VGDR+L +NN SL+ EA+ +L+ E V LK+ K
Sbjct: 238 RLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 278
Score = 58.9 bits (141), Expect = 3e-08
Identities = 47/180 (26%), Positives = 84/180 (46%), Gaps = 12/180 (6%)
Query: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
SG G + GG P + + I P A G L+V D +L +N + + + +
Sbjct: 106 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 165
Query: 622 ANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEP- 680
A + L++A ++ + + E+V+ +KL K LG +I+ + P
Sbjct: 166 AVEALKEAGSIVRLYVRRRRPILETVV------EIKLFKGPK-GLGFSIAGGVGNQHIPG 218
Query: 681 ---LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK 737
+ ++ I G A + G L+ GD+LL ++N L+ E+AV IL+ ++V LK+ K
Sbjct: 219 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 278
Score = 57.4 bits (137), Expect = 8e-08
Identities = 52/201 (25%), Positives = 90/201 (44%), Gaps = 14/201 (6%)
Query: 246 VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLH 305
V L+K GF + GG +G + ++++ GGPAD G L+ GD++LSV+GI L
Sbjct: 422 VVLHKGSTGLGFNIVGGEDGEG-----IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476
Query: 306 GASHATALATLRQCSHEALFQVEY---DVATPDTVANASGPLMVEIVKTPGSALGISLTT 362
GASH A A L+ +Y D A + + M+ + GS +
Sbjct: 477 GASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQK 536
Query: 363 TSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVR 422
SL +++ D+ K + + + + GD + I+ + E +L SE++
Sbjct: 537 RSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV--MLEGDSEEMG 594
Query: 423 LEILPVPQSQRPLRPQRQVVK 443
+ +P +R R +R +K
Sbjct: 595 V----IPSKRRVERKERARLK 611
Score = 49.3 bits (116), Expect = 2e-05
Identities = 37/101 (36%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 147 ELIKKEGST-LGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLR 205
+++ +GST LG I GG D +G VS + GG A S L GD I SVNGI L
Sbjct: 421 KVVLHKGSTGLGFNIVGGEDGEGI-FVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479
Query: 206 HDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDV 246
H++ LK G+ V + +Y+ PE+ R +K D+
Sbjct: 480 HEQAAAALKGAGQTVTIIAQYQ-----PEDYARFEAKIHDL 515
Score = 48.1 bits (113), Expect = 5e-05
Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 11/111 (9%)
Query: 120 KDAGGADVSLACRRQSIPEEFRGITVVEL-IKKEGSTLGLTISGGTDK-----DGKPRVS 173
K+AG RR+ I E TVVE+ + K LG +I+GG D V+
Sbjct: 171 KEAGSIVRLYVRRRRPILE-----TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVT 225
Query: 174 NLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV 224
+ GG A + L +GD + VN L + H+E + +LKN E V L+V
Sbjct: 226 KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 1/67 (1%)
Query: 764 LGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQV 823
LG I G E+ + I +S + G A+ +G + GD+IL++N + L+G +A L+
Sbjct: 431 LGFNIVGGEDG-EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489
Query: 824 AGETVTL 830
AG+TVT+
Sbjct: 490 AGQTVTI 496
Score = 36.6 bits (83), Expect = 0.14
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFDRVLQ 1088
E ++TL + GFS++ G + G+++ + P G A G L+ D +L+
Sbjct: 95 EFEEITLERG--NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 152
Query: 1089 VNHVRTRDFDCCLAVPLLAEAGDVLELIISRK 1120
VN V + AV L EAG ++ L + R+
Sbjct: 153 VNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 184
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 84.3 bits (207), Expect = 6e-16
Identities = 84/328 (25%), Positives = 136/328 (41%), Gaps = 66/328 (20%)
Query: 149 IKKEGSTLGLTISGGTDK-----DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTR 203
+++ S LG +I+GGTD D ++ + GG AA+ L + D I VN + +
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
Query: 204 LRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGA 263
+ H + + LK G V L V+ P + K +++ L K GF + GG
Sbjct: 287 VTHSKAVEALKEAGSIVRLYVKRRKP---------VSEKIMEIKLIKGPKGLGFSIAGGV 337
Query: 264 ---HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
H G S + +T + GG A ++G L++GD+LL+V+ + L +H A+ L+ S
Sbjct: 338 GNQHIPGDNS--IYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTS 395
Query: 321 HEALFQVEYDV--------ATPDTVANASGPLMVEIVKTPGSALG---ISLTTTSLRNKS 369
+V A PD ++S P V+ +P S LG S S +K+
Sbjct: 396 DFVYLKVAKPTSMYMNDGYAPPDITNSSSQP--VDNHVSPSSFLGQTPASPARYSPVSKA 453
Query: 370 VITIDRI--KPASVV--------------------------------DRSGALHPGDHIL 395
V+ D I +P VV D SG L GD I+
Sbjct: 454 VLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRII 513
Query: 396 SIDGTSMEHCSLLEATKLLASISEKVRL 423
S++ + S +A L + + V +
Sbjct: 514 SVNSVDLRAASHEQAAAALKNAGQAVTI 541
Score = 80.9 bits (198), Expect = 6e-15
Identities = 78/314 (24%), Positives = 130/314 (41%), Gaps = 50/314 (15%)
Query: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
SG G + GG + + I A + G L+V D +L +N + D T +
Sbjct: 232 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291
Query: 622 ANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPL 681
A + L++A ++ ++ V+E ++ +K PK + + + +
Sbjct: 292 AVEALKEAGSIVRLYVKRRKPVSEKIMEIK---LIKGPKGLGFSIAGGVGNQHIPGDNSI 348
Query: 682 IISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK---- 737
++ I +G AH+ G L+ GDKLLA++N+ L+ E+AV L+ D V LK+ K
Sbjct: 349 YVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSM 408
Query: 738 ---------DEDNSDELETTGAVSYT--------------------------------VE 756
D NS VS + V
Sbjct: 409 YMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVV 468
Query: 757 LKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSE 816
L R LG I G E+ + I IS + G A+ +G + GDRI+++N+V L+ +
Sbjct: 469 LHRGSTGLGFNIVGGEDG-EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQ 527
Query: 817 AIHLLQVAGETVTL 830
A L+ AG+ VT+
Sbjct: 528 AAAALKNAGQAVTI 541
Score = 79.0 bits (193), Expect = 2e-14
Identities = 68/258 (26%), Positives = 105/258 (40%), Gaps = 57/258 (22%)
Query: 120 KDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDK-----DGKPRVSN 174
K+AG RR+ + E+ I ++ K LG +I+GG D V+
Sbjct: 297 KEAGSIVRLYVKRRKPVSEKIMEIKLI----KGPKGLGFSIAGGVGNQHIPGDNSIYVTK 352
Query: 175 LRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV---------E 225
+ GG A + L IGD + +VN + L + H+E +T LKN + V L+V +
Sbjct: 353 IIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMND 412
Query: 226 YELPP-----------------------PAPENNPRIISKTV-----------DVSLYKE 251
PP PA +SK V V L++
Sbjct: 413 GYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRG 472
Query: 252 GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHAT 311
GF + GG +G + ++++ GGPAD G L+ GDR++SV+ + L ASH
Sbjct: 473 STGLGFNIVGGEDGEG-----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQ 527
Query: 312 ALATLRQCSHEALFQVEY 329
A A L+ +Y
Sbjct: 528 AAAALKNAGQAVTIVAQY 545
Score = 65.1 bits (157), Expect = 4e-10
Identities = 58/212 (27%), Positives = 103/212 (48%), Gaps = 24/212 (11%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED 740
+ I+ I G A + G L D +L ++ + + + AV+ L++ +V+L +++ +
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP 312
Query: 741 NSDELETTGAVSYTVELKRYGGP--LGITISG----TEEPFD-PIVISGLTKRGLAERTG 793
S+++ +E+K GP LG +I+G P D I ++ + + G A + G
Sbjct: 313 VSEKI---------MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 363
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQL-----DRPLLPRKSGSL 848
+ +GD++LA+NNV L+ EA+ L+ + V LK+ K D P + S
Sbjct: 364 KLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSS 423
Query: 849 SETSDADEDPADALKGGLPA--ARFSPAVPSV 878
S+ D P+ L G PA AR+SP +V
Sbjct: 424 SQPVDNHVSPSSFL-GQTPASPARYSPVSKAV 454
Score = 59.3 bits (142), Expect = 2e-08
Identities = 97/463 (20%), Positives = 173/463 (37%), Gaps = 103/463 (22%)
Query: 229 PPPAPENNPRIISKTV-----------DVSLYKEGNSFGFVLRGGAHEDGH--KSRPLVL 275
PPP N + + T +++L + + GF + GG ++ H + +
Sbjct: 197 PPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGT-DNPHIGDDSSIFI 255
Query: 276 TYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPD 335
T + GG A ++G L+V D +L V+ + + +H+ A+ L++ V+ +
Sbjct: 256 TKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSE 315
Query: 336 TVANASGPLMVEIVKTPGSALGISLT----TTSLRNKSVITIDRIKPASVVDRSGALHPG 391
+ + ++++K P LG S+ + + I + +I + G L G
Sbjct: 316 KI------MEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIG 368
Query: 392 DHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLH 451
D +L+++ +E + EA L + S+ V L KV + ++
Sbjct: 369 DKLLAVNNVCLEEVTHEEAVTALKNTSDFVYL-------------------KVAKPTSMY 409
Query: 452 RWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGS 511
D P D + S SS P + +F P++ R S
Sbjct: 410 MNDGYAPP--------------------DITNS-SSQPVDNHVSPSSFLGQTPASPARYS 448
Query: 512 QPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQG 571
P+S + +G R K L S+ G G IV E E
Sbjct: 449 -PVS-KAVLGDDEITREPRKVVLHRGST--GLGFNIVGGEDGE----------------- 487
Query: 572 GIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAAL 631
GIF + FI PA+ G L+ GDR++S+N + + E+A L++A
Sbjct: 488 GIF----------ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQ 537
Query: 632 AHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSAS 674
A +V + + F K+ R + +ISS S
Sbjct: 538 AVTIVAQYRPE-------EYSRFEAKIHDLREQMMNSSISSGS 573
Score = 47.0 bits (110), Expect = 1e-04
Identities = 35/101 (34%), Positives = 49/101 (48%), Gaps = 7/101 (6%)
Query: 147 ELIKKEGST-LGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLR 205
+++ GST LG I GG D +G +S + GG A S L GD I SVN + L
Sbjct: 466 KVVLHRGSTGLGFNIVGGEDGEGI-FISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 206 HDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDV 246
H++ LKN G+ V + +Y PE R +K D+
Sbjct: 525 HEQAAAALKNAGQAVTIVAQYR-----PEEYSRFEAKIHDL 560
Score = 37.0 bits (84), Expect = 0.11
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 3/87 (3%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRT 1094
E KV LH+ GF++ G +G+++ + GPA G L+ DR++ VN V
Sbjct: 463 EPRKVVLHRGST--GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDL 520
Query: 1095 RDFDCCLAVPLLAEAGDVLELIISRKP 1121
R A L AG + ++ +P
Sbjct: 521 RAASHEQAAAALKNAGQAVTIVAQYRP 547
Score = 35.4 bits (80), Expect = 0.31
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFDRVLQ 1088
E ++TL + GFS++ G + +++ + G A + G L+ D +L+
Sbjct: 221 EYEEITLERG--NSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 1089 VNHVRTRDFDCCLAVPLLAEAGDVLELIISRK 1120
VN V RD AV L EAG ++ L + R+
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 84.3 bits (207), Expect = 6e-16
Identities = 84/328 (25%), Positives = 136/328 (41%), Gaps = 66/328 (20%)
Query: 149 IKKEGSTLGLTISGGTDK-----DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTR 203
+++ S LG +I+GGTD D ++ + GG AA+ L + D I VN + +
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
Query: 204 LRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGA 263
+ H + + LK G V L V+ P + K +++ L K GF + GG
Sbjct: 287 VTHSKAVEALKEAGSIVRLYVKRRKP---------VSEKIMEIKLIKGPKGLGFSIAGGV 337
Query: 264 ---HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
H G S + +T + GG A ++G L++GD+LL+V+ + L +H A+ L+ S
Sbjct: 338 GNQHIPGDNS--IYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTS 395
Query: 321 HEALFQVEYDV--------ATPDTVANASGPLMVEIVKTPGSALG---ISLTTTSLRNKS 369
+V A PD ++S P V+ +P S LG S S +K+
Sbjct: 396 DFVYLKVAKPTSMYMNDGYAPPDITNSSSQP--VDNHVSPSSFLGQTPASPARYSPVSKA 453
Query: 370 VITIDRI--KPASVV--------------------------------DRSGALHPGDHIL 395
V+ D I +P VV D SG L GD I+
Sbjct: 454 VLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRII 513
Query: 396 SIDGTSMEHCSLLEATKLLASISEKVRL 423
S++ + S +A L + + V +
Sbjct: 514 SVNSVDLRAASHEQAAAALKNAGQAVTI 541
Score = 80.9 bits (198), Expect = 6e-15
Identities = 78/314 (24%), Positives = 130/314 (41%), Gaps = 50/314 (15%)
Query: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
SG G + GG + + I A + G L+V D +L +N + D T +
Sbjct: 232 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291
Query: 622 ANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPL 681
A + L++A ++ ++ V+E ++ +K PK + + + +
Sbjct: 292 AVEALKEAGSIVRLYVKRRKPVSEKIMEIK---LIKGPKGLGFSIAGGVGNQHIPGDNSI 348
Query: 682 IISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK---- 737
++ I +G AH+ G L+ GDKLLA++N+ L+ E+AV L+ D V LK+ K
Sbjct: 349 YVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSM 408
Query: 738 ---------DEDNSDELETTGAVSYT--------------------------------VE 756
D NS VS + V
Sbjct: 409 YMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVV 468
Query: 757 LKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSE 816
L R LG I G E+ + I IS + G A+ +G + GDRI+++N+V L+ +
Sbjct: 469 LHRGSTGLGFNIVGGEDG-EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQ 527
Query: 817 AIHLLQVAGETVTL 830
A L+ AG+ VT+
Sbjct: 528 AAAALKNAGQAVTI 541
Score = 79.0 bits (193), Expect = 2e-14
Identities = 68/258 (26%), Positives = 105/258 (40%), Gaps = 57/258 (22%)
Query: 120 KDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDK-----DGKPRVSN 174
K+AG RR+ + E+ I ++ K LG +I+GG D V+
Sbjct: 297 KEAGSIVRLYVKRRKPVSEKIMEIKLI----KGPKGLGFSIAGGVGNQHIPGDNSIYVTK 352
Query: 175 LRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV---------E 225
+ GG A + L IGD + +VN + L + H+E +T LKN + V L+V +
Sbjct: 353 IIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMND 412
Query: 226 YELPP-----------------------PAPENNPRIISKTV-----------DVSLYKE 251
PP PA +SK V V L++
Sbjct: 413 GYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRG 472
Query: 252 GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHAT 311
GF + GG +G + ++++ GGPAD G L+ GDR++SV+ + L ASH
Sbjct: 473 STGLGFNIVGGEDGEG-----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQ 527
Query: 312 ALATLRQCSHEALFQVEY 329
A A L+ +Y
Sbjct: 528 AAAALKNAGQAVTIVAQY 545
Score = 65.1 bits (157), Expect = 4e-10
Identities = 58/212 (27%), Positives = 103/212 (48%), Gaps = 24/212 (11%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED 740
+ I+ I G A + G L D +L ++ + + + AV+ L++ +V+L +++ +
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP 312
Query: 741 NSDELETTGAVSYTVELKRYGGP--LGITISG----TEEPFD-PIVISGLTKRGLAERTG 793
S+++ +E+K GP LG +I+G P D I ++ + + G A + G
Sbjct: 313 VSEKI---------MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 363
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQL-----DRPLLPRKSGSL 848
+ +GD++LA+NNV L+ EA+ L+ + V LK+ K D P + S
Sbjct: 364 KLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSS 423
Query: 849 SETSDADEDPADALKGGLPA--ARFSPAVPSV 878
S+ D P+ L G PA AR+SP +V
Sbjct: 424 SQPVDNHVSPSSFL-GQTPASPARYSPVSKAV 454
Score = 59.3 bits (142), Expect = 2e-08
Identities = 97/463 (20%), Positives = 173/463 (37%), Gaps = 103/463 (22%)
Query: 229 PPPAPENNPRIISKTV-----------DVSLYKEGNSFGFVLRGGAHEDGH--KSRPLVL 275
PPP N + + T +++L + + GF + GG ++ H + +
Sbjct: 197 PPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGT-DNPHIGDDSSIFI 255
Query: 276 TYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPD 335
T + GG A ++G L+V D +L V+ + + +H+ A+ L++ V+ +
Sbjct: 256 TKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSE 315
Query: 336 TVANASGPLMVEIVKTPGSALGISLT----TTSLRNKSVITIDRIKPASVVDRSGALHPG 391
+ + ++++K P LG S+ + + I + +I + G L G
Sbjct: 316 KI------MEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIG 368
Query: 392 DHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLH 451
D +L+++ +E + EA L + S+ V L KV + ++
Sbjct: 369 DKLLAVNNVCLEEVTHEEAVTALKNTSDFVYL-------------------KVAKPTSMY 409
Query: 452 RWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGS 511
D P D + S SS P + +F P++ R S
Sbjct: 410 MNDGYAPP--------------------DITNS-SSQPVDNHVSPSSFLGQTPASPARYS 448
Query: 512 QPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQG 571
P+S + +G R K L S+ G G IV E E
Sbjct: 449 -PVS-KAVLGDDEITREPRKVVLHRGST--GLGFNIVGGEDGE----------------- 487
Query: 572 GIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAAL 631
GIF + FI PA+ G L+ GDR++S+N + + E+A L++A
Sbjct: 488 GIF----------ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQ 537
Query: 632 AHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSAS 674
A +V + + F K+ R + +ISS S
Sbjct: 538 AVTIVAQYRPE-------EYSRFEAKIHDLREQMMNSSISSGS 573
Score = 47.0 bits (110), Expect = 1e-04
Identities = 35/101 (34%), Positives = 49/101 (48%), Gaps = 7/101 (6%)
Query: 147 ELIKKEGST-LGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLR 205
+++ GST LG I GG D +G +S + GG A S L GD I SVN + L
Sbjct: 466 KVVLHRGSTGLGFNIVGGEDGEGI-FISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 206 HDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDV 246
H++ LKN G+ V + +Y PE R +K D+
Sbjct: 525 HEQAAAALKNAGQAVTIVAQYR-----PEEYSRFEAKIHDL 560
Score = 37.0 bits (84), Expect = 0.11
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 3/87 (3%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRT 1094
E KV LH+ GF++ G +G+++ + GPA G L+ DR++ VN V
Sbjct: 463 EPRKVVLHRGST--GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDL 520
Query: 1095 RDFDCCLAVPLLAEAGDVLELIISRKP 1121
R A L AG + ++ +P
Sbjct: 521 RAASHEQAAAALKNAGQAVTIVAQYRP 547
Score = 35.4 bits (80), Expect = 0.31
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFDRVLQ 1088
E ++TL + GFS++ G + +++ + G A + G L+ D +L+
Sbjct: 221 EYEEITLERG--NSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 1089 VNHVRTRDFDCCLAVPLLAEAGDVLELIISRK 1120
VN V RD AV L EAG ++ L + R+
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 83.2 bits (204), Expect = 1e-15
Identities = 84/349 (24%), Positives = 141/349 (40%), Gaps = 75/349 (21%)
Query: 120 KDAGGADVSLACRRQSIPEEFRGITVVEL-IKKEGSTLGLTISGGTDK-----DGKPRVS 173
K+AG V L RR+ P E T++E+ + K LG +I+GG D ++
Sbjct: 204 KEAGPV-VRLVVRRRQPPPE----TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYIT 258
Query: 174 NLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV--------- 224
+ GG A + L IGD + +VN +L +RH+E + LKN + V L+V
Sbjct: 259 KIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLN 318
Query: 225 ------------------------------------EYELPPPAPENN----PRIISKTV 244
Y PP P PR +
Sbjct: 319 DMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEE 378
Query: 245 D-------VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLL 297
D + L+K GF + GG +G + ++++ GGPAD G L+ GDR+L
Sbjct: 379 DFTREPRKIILHKGSTGLGFNIVGGEDGEG-----IFVSFILAGGPADLSGELRRGDRIL 433
Query: 298 SVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALG 357
SV+G+ L A+H A A L++ +Y + L +++ + S+
Sbjct: 434 SVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGS 493
Query: 358 ISLTTTSLRN---KSVITIDRIKPASVVDRSGALHPGDHILSIDGTSME 403
SL T+ R+ +++ DR + + + + + GD + I+ + E
Sbjct: 494 GSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDE 542
Score = 82.8 bits (203), Expect = 2e-15
Identities = 56/188 (29%), Positives = 89/188 (47%), Gaps = 19/188 (10%)
Query: 148 LIKKEGSTLGLTISGGTDKDGKPR-----VSNLRPGGLAARSDLLNIGDYIRSVNGIHLT 202
++++ S LG +I+GG D P ++ + PGG AA L + D + VN + ++
Sbjct: 133 VLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVS 192
Query: 203 RLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGG 262
+ H + LK G V L V PPP ++V+L K GF + GG
Sbjct: 193 EVVHSRAVEALKEAGPVVRLVVRRRQPPP---------ETIMEVNLLKGPKGLGFSIAGG 243
Query: 263 A---HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQC 319
H G S + +T + GG A ++G L++GDRLL+V+ L H A+A+L+
Sbjct: 244 IGNQHIPGDNS--IYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT 301
Query: 320 SHEALFQV 327
S +V
Sbjct: 302 SDMVYLKV 309
Score = 70.1 bits (170), Expect = 1e-11
Identities = 104/444 (23%), Positives = 167/444 (37%), Gaps = 88/444 (19%)
Query: 242 KTVDVSLYKEGNSFGFVLRGGAHEDGHKSRP-LVLTYVRPGGPADREGSLKVGDRLLSVD 300
K ++ L + + GF + GG P + +T + PGG A +G L V D +L V+
Sbjct: 128 KYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 187
Query: 301 GIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISL 360
+ + H+ A+ L++ V P+T+ + V ++K P LG S+
Sbjct: 188 EVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETI------MEVNLLKGP-KGLGFSI 240
Query: 361 T----TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLAS 416
+ + I I +I + G L GD +L+++ T+++ EA L +
Sbjct: 241 AGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKN 300
Query: 417 ISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATP 476
S+ V L KV + LH D P P +A+
Sbjct: 301 TSDMVYL-------------------KVAKPGSLHLNDMYAP------------PDYAST 329
Query: 477 --AGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSL 534
A D S +S+ + S P +P PR + R K +
Sbjct: 330 FTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRK--I 387
Query: 535 SLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPA 594
L + G G IV E E GIF V FI PA
Sbjct: 388 ILHKGSTGLGFNIVGGEDGE-----------------GIF----------VSFILAGGPA 420
Query: 595 ERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEV---EFDVAESVI--- 648
+ G L+ GDR+LS+NG+ + T E+A L+ A + +V + E+ ES I
Sbjct: 421 DLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDL 480
Query: 649 --------PSSGTFHVKLPKKRSV 664
SSG+ ++ +KRS+
Sbjct: 481 REQMMNSSMSSGSGSLRTSEKRSL 504
Score = 62.0 bits (149), Expect = 3e-09
Identities = 48/176 (27%), Positives = 80/176 (45%), Gaps = 4/176 (2%)
Query: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
SG G + GGI P + + I P A G L V D VL +N + +
Sbjct: 139 SGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSR 198
Query: 622 ANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPL 681
A + L++A ++V+ E+++ + +K PK + I + +
Sbjct: 199 AVEALKEAGPVVRLVVRRRQPPPETIMEVN---LLKGPKGLGFSIAGGIGNQHIPGDNSI 255
Query: 682 IISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK 737
I+ I +G A + G L+ GD+LLA++N L + E+AV L+ D+V LK+ K
Sbjct: 256 YITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK 311
Score = 55.8 bits (133), Expect = 2e-07
Identities = 43/161 (26%), Positives = 79/161 (49%), Gaps = 16/161 (9%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDED 740
+ I+ I G A G L D +L ++ + + AV+ L++ +V+L +R+ +
Sbjct: 160 IFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQP 219
Query: 741 NSDELETTGAVSYTVELKRYGGP--LGITISG----TEEPFD-PIVISGLTKRGLAERTG 793
+ + +E+ GP LG +I+G P D I I+ + + G A++ G
Sbjct: 220 PPETI---------MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDG 270
Query: 794 AIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ +GDR+LA+NN +L+ EA+ L+ + V LK+ K
Sbjct: 271 RLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK 311
Score = 41.2 bits (95), Expect = 0.006
Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 1/67 (1%)
Query: 764 LGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQV 823
LG I G E+ + I +S + G A+ +G + GDRIL++N V+L+ +A L+
Sbjct: 396 LGFNIVGGEDG-EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKR 454
Query: 824 AGETVTL 830
AG++VT+
Sbjct: 455 AGQSVTI 461
Score = 38.5 bits (88), Expect = 0.037
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRT 1094
E K+ LHK GF++ G +G++V + GPA G L+ DR+L VN V
Sbjct: 383 EPRKIILHKGST--GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
Query: 1095 RDFDCCLAVPLLAEAGDVLELIISRKP 1121
R+ A L AG + ++ +P
Sbjct: 441 RNATHEQAAAALKRAGQSVTIVAQYRP 467
Score = 35.4 bits (80), Expect = 0.31
Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 7/76 (9%)
Query: 1052 GFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAVP 1104
GFS++ G+ + G+++ + P G A G L D VL+VN V + AV
Sbjct: 142 GFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVE 201
Query: 1105 LLAEAGDVLELIISRK 1120
L EAG V+ L++ R+
Sbjct: 202 ALKEAGPVVRLVVRRR 217
Score = 34.3 bits (77), Expect = 0.69
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 10/101 (9%)
Query: 1032 PTPLEMHKVTLHKDPMRHDFGFSVSDGLL------EKGVYVHTVRPDGPAHRGG-LQPFD 1084
P P + +V L K P GFS++ G+ + +Y+ + G A + G LQ D
Sbjct: 219 PPPETIMEVNLLKGPK--GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGD 276
Query: 1085 RVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAH 1125
R+L VN+ +D AV L D++ L ++ KP + H
Sbjct: 277 RLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVA-KPGSLH 316
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 79.7 bits (195), Expect = 1e-14
Identities = 90/328 (27%), Positives = 127/328 (38%), Gaps = 56/328 (17%)
Query: 203 RLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGG 262
RLRH LK G PP PE + + V L KE + GF + GG
Sbjct: 897 RLRHQLSFLPLKGAGS--------SCPPSPPEISA---GEIYFVELVKEDGTLGFSVTGG 945
Query: 263 AHEDGHKSRPLVLTYVR---PGGPADREGSLKVGDRLLSVDGIPLHGASHATALATL--- 316
+ S P YV+ PGGPA +EG + GDRLL VDG+ L G +H A+ L
Sbjct: 946 INT----SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGP 1001
Query: 317 ----------------RQCSH------EALFQVEYDVATP----DTVANASGPLMVEIVK 350
+QC + V A P V+ GP +K
Sbjct: 1002 GQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLK 1061
Query: 351 TPGSALGISLT-----TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405
+ LG S + S ++ I R+ P + +GA+ GD IL+++G S E
Sbjct: 1062 KNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGL 1121
Query: 406 SLLEATKLLASISEKVRLEIL-PVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPR 464
E LL ++V L + P P + L + Q ++ ++ R C SC SP
Sbjct: 1122 IFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTR-ATCTDSCTSPI 1180
Query: 465 PGHCRMPTWATPAGQDQSRSLSSTPFSS 492
+ +W A D L P SS
Sbjct: 1181 LD--QEDSWRDSASPDAGEGLGLRPESS 1206
Score = 61.2 bits (147), Expect = 5e-09
Identities = 70/249 (28%), Positives = 104/249 (41%), Gaps = 45/249 (18%)
Query: 135 SIPEEFRG-ITVVELIKKEGSTLGLTISGGTDKD---GKPRVSNLRPGGLAARSDLLNIG 190
S PE G I VEL+K++G TLG +++GG + G V ++ PGG AA+ + G
Sbjct: 917 SPPEISAGEIYFVELVKEDG-TLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQG 975
Query: 191 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELP------PPA------------ 232
D + V+G+ L L H + + L G+ L +E +P P A
Sbjct: 976 DRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVS 1035
Query: 233 -----PENNPRIISKT----VDVSLYKEGNSFGFVLRGGAHED-GHKSRPLV-LTYVRPG 281
P +S T +V L K N GF E H LV + + PG
Sbjct: 1036 LVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 1095
Query: 282 GPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHE-----------ALFQVEYD 330
PA+ G++ GD +L+V+G G L LR E AL ++E +
Sbjct: 1096 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQE 1155
Query: 331 VATPDTVAN 339
TP+ A+
Sbjct: 1156 WQTPELSAD 1164
Score = 52.4 bits (124), Expect = 2e-06
Identities = 29/89 (32%), Positives = 54/89 (60%), Gaps = 6/89 (6%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDG----LLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVN 1090
E+ +VTL +DP R FGF +++G + G+++ ++ P GPA + ++P ++L +N
Sbjct: 750 EIVRVTLKRDPHR-GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 808
Query: 1091 HVRTRDFDCCLAVPLLAEAGDVLELIISR 1119
H+ F +AV ++ + D +ELIIS+
Sbjct: 809 HISLEGFTFNMAVRMIQNSPDNIELIISQ 837
Score = 50.8 bits (120), Expect = 7e-06
Identities = 50/185 (27%), Positives = 74/185 (40%), Gaps = 35/185 (18%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK--- 737
+ + I G A + G + GD+LL +D + L + AVQ L + +L + +
Sbjct: 955 IYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
Query: 738 --------------DEDNSDELET------------TGAVSYTVELKRYGGPLGITISGT 771
DE + L T T + V+LK+ LG +
Sbjct: 1015 RSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQM 1074
Query: 772 EEPF------DPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAG 825
E+ D + I L AE GAI GD ILA+N S +G E +HLL+ A
Sbjct: 1075 EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAP 1134
Query: 826 ETVTL 830
+ VTL
Sbjct: 1135 QEVTL 1139
Score = 37.7 bits (86), Expect = 0.063
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 2/66 (3%)
Query: 769 SGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETV 828
SG +P I IS + G AE+ I G +ILA+N++SL+G + A+ ++Q + + +
Sbjct: 774 SGQADP--GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNI 831
Query: 829 TLKIKK 834
L I +
Sbjct: 832 ELIISQ 837
Score = 37.7 bits (86), Expect = 0.063
Identities = 47/203 (23%), Positives = 75/203 (36%), Gaps = 37/203 (18%)
Query: 566 GLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
G + GGI T V I P PA + G + GDR+L ++G+ T ++A Q
Sbjct: 939 GFSVTGGI-NTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQC 997
Query: 626 LRDAALAHKVVLEVEFDVAESVIPSSG------------------------------TFH 655
L ++VLE + PS+ F
Sbjct: 998 LTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFE 1057
Query: 656 VKLPKKRSVELGITI-----SSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNI 710
VKL KK + LG + S S + + + I + G A G + GD +LA++
Sbjct: 1058 VKL-KKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGR 1116
Query: 711 RLDNCPMEDAVQILRQCEDLVKL 733
+ ++ + +LR V L
Sbjct: 1117 STEGLIFQEVLHLLRGAPQEVTL 1139
Score = 37.0 bits (84), Expect = 0.11
Identities = 18/63 (28%), Positives = 37/63 (58%), Gaps = 1/63 (1%)
Query: 255 FGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALA 314
FGFV+ G + G + ++ + PGGPA++ ++K G ++L+++ I L G + A+
Sbjct: 764 FGFVINEGEYS-GQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 822
Query: 315 TLR 317
++
Sbjct: 823 MIQ 825
Score = 36.6 bits (83), Expect = 0.14
Identities = 26/74 (35%), Positives = 38/74 (51%), Gaps = 5/74 (6%)
Query: 1052 GFSVSDGLLEK----GVYVHTVRPDGPAHR-GGLQPFDRVLQVNHVRTRDFDCCLAVPLL 1106
GFSV+ G+ G+YV ++ P GPA + G + DR+LQV+ V AV L
Sbjct: 939 GFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL 998
Query: 1107 AEAGDVLELIISRK 1120
G V L++ R+
Sbjct: 999 TGPGQVARLVLERR 1012
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 79.7 bits (195), Expect = 1e-14
Identities = 90/328 (27%), Positives = 127/328 (38%), Gaps = 56/328 (17%)
Query: 203 RLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGG 262
RLRH LK G PP PE + + V L KE + GF + GG
Sbjct: 919 RLRHQLSFLPLKGAGS--------SCPPSPPEISA---GEIYFVELVKEDGTLGFSVTGG 967
Query: 263 AHEDGHKSRPLVLTYVR---PGGPADREGSLKVGDRLLSVDGIPLHGASHATALATL--- 316
+ S P YV+ PGGPA +EG + GDRLL VDG+ L G +H A+ L
Sbjct: 968 INT----SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGP 1023
Query: 317 ----------------RQCSH------EALFQVEYDVATP----DTVANASGPLMVEIVK 350
+QC + V A P V+ GP +K
Sbjct: 1024 GQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLK 1083
Query: 351 TPGSALGISLT-----TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405
+ LG S + S ++ I R+ P + +GA+ GD IL+++G S E
Sbjct: 1084 KNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGL 1143
Query: 406 SLLEATKLLASISEKVRLEIL-PVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPR 464
E LL ++V L + P P + L + Q ++ ++ R C SC SP
Sbjct: 1144 IFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTR-ATCTDSCTSPI 1202
Query: 465 PGHCRMPTWATPAGQDQSRSLSSTPFSS 492
+ +W A D L P SS
Sbjct: 1203 LD--QEDSWRDSASPDAGEGLGLRPESS 1228
Score = 61.2 bits (147), Expect = 5e-09
Identities = 70/249 (28%), Positives = 104/249 (41%), Gaps = 45/249 (18%)
Query: 135 SIPEEFRG-ITVVELIKKEGSTLGLTISGGTDKD---GKPRVSNLRPGGLAARSDLLNIG 190
S PE G I VEL+K++G TLG +++GG + G V ++ PGG AA+ + G
Sbjct: 939 SPPEISAGEIYFVELVKEDG-TLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQG 997
Query: 191 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELP------PPA------------ 232
D + V+G+ L L H + + L G+ L +E +P P A
Sbjct: 998 DRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVS 1057
Query: 233 -----PENNPRIISKT----VDVSLYKEGNSFGFVLRGGAHED-GHKSRPLV-LTYVRPG 281
P +S T +V L K N GF E H LV + + PG
Sbjct: 1058 LVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 1117
Query: 282 GPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHE-----------ALFQVEYD 330
PA+ G++ GD +L+V+G G L LR E AL ++E +
Sbjct: 1118 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQE 1177
Query: 331 VATPDTVAN 339
TP+ A+
Sbjct: 1178 WQTPELSAD 1186
Score = 52.4 bits (124), Expect = 2e-06
Identities = 29/89 (32%), Positives = 54/89 (60%), Gaps = 6/89 (6%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDG----LLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVN 1090
E+ +VTL +DP R FGF +++G + G+++ ++ P GPA + ++P ++L +N
Sbjct: 772 EIVRVTLKRDPHR-GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 830
Query: 1091 HVRTRDFDCCLAVPLLAEAGDVLELIISR 1119
H+ F +AV ++ + D +ELIIS+
Sbjct: 831 HISLEGFTFNMAVRMIQNSPDNIELIISQ 859
Score = 50.8 bits (120), Expect = 7e-06
Identities = 50/185 (27%), Positives = 74/185 (40%), Gaps = 35/185 (18%)
Query: 681 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK--- 737
+ + I G A + G + GD+LL +D + L + AVQ L + +L + +
Sbjct: 977 IYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1036
Query: 738 --------------DEDNSDELET------------TGAVSYTVELKRYGGPLGITISGT 771
DE + L T T + V+LK+ LG +
Sbjct: 1037 RSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQM 1096
Query: 772 EEPF------DPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAG 825
E+ D + I L AE GAI GD ILA+N S +G E +HLL+ A
Sbjct: 1097 EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAP 1156
Query: 826 ETVTL 830
+ VTL
Sbjct: 1157 QEVTL 1161
Score = 37.7 bits (86), Expect = 0.063
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 2/66 (3%)
Query: 769 SGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETV 828
SG +P I IS + G AE+ I G +ILA+N++SL+G + A+ ++Q + + +
Sbjct: 796 SGQADP--GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNI 853
Query: 829 TLKIKK 834
L I +
Sbjct: 854 ELIISQ 859
Score = 37.7 bits (86), Expect = 0.063
Identities = 47/203 (23%), Positives = 75/203 (36%), Gaps = 37/203 (18%)
Query: 566 GLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
G + GGI T V I P PA + G + GDR+L ++G+ T ++A Q
Sbjct: 961 GFSVTGGI-NTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQC 1019
Query: 626 LRDAALAHKVVLEVEFDVAESVIPSSG------------------------------TFH 655
L ++VLE + PS+ F
Sbjct: 1020 LTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFE 1079
Query: 656 VKLPKKRSVELGITI-----SSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNI 710
VKL KK + LG + S S + + + I + G A G + GD +LA++
Sbjct: 1080 VKL-KKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGR 1138
Query: 711 RLDNCPMEDAVQILRQCEDLVKL 733
+ ++ + +LR V L
Sbjct: 1139 STEGLIFQEVLHLLRGAPQEVTL 1161
Score = 37.0 bits (84), Expect = 0.11
Identities = 18/63 (28%), Positives = 37/63 (58%), Gaps = 1/63 (1%)
Query: 255 FGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALA 314
FGFV+ G + G + ++ + PGGPA++ ++K G ++L+++ I L G + A+
Sbjct: 786 FGFVINEGEYS-GQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 844
Query: 315 TLR 317
++
Sbjct: 845 MIQ 847
Score = 36.6 bits (83), Expect = 0.14
Identities = 26/74 (35%), Positives = 38/74 (51%), Gaps = 5/74 (6%)
Query: 1052 GFSVSDGLLEK----GVYVHTVRPDGPAHR-GGLQPFDRVLQVNHVRTRDFDCCLAVPLL 1106
GFSV+ G+ G+YV ++ P GPA + G + DR+LQV+ V AV L
Sbjct: 961 GFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL 1020
Query: 1107 AEAGDVLELIISRK 1120
G V L++ R+
Sbjct: 1021 TGPGQVARLVLERR 1034
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 79.3 bits (194), Expect = 2e-14
Identities = 185/881 (20%), Positives = 299/881 (33%), Gaps = 234/881 (26%)
Query: 137 PEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSV 196
P E +G + ++K G T+ GG + D ++ +L G AA + GD I SV
Sbjct: 463 PSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522
Query: 197 NGIHLTRLRHDEIITLLKN--VGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNS 254
N + H +++ + ++ +G V LE+ P P ++P T L KE
Sbjct: 523 NDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKE--- 579
Query: 255 FGFVLRGGAHEDGHKSRPLVLTYV------RPGGPADREGSLKVGDRLLSVDGIPLHGAS 308
++ G D S V RP PAD + S G P S
Sbjct: 580 -PIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASN--------SSHGYPNDTVS 630
Query: 309 HATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNK 368
A+++AT P+ + V IVK P +G T
Sbjct: 631 LASSIAT-----------------QPELIT-------VHIVKGP---MGFGFTIADSPGG 663
Query: 369 SVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLL------ASISEKVR 422
R+K R L GD I+ ++ +++ + + +L + ++ V+
Sbjct: 664 GG---QRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 423 LEILPVPQ---SQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQ 479
LPVP+ +PL + Q S HR S H+ P H P +
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHR------SLHTASPSHSTQVLPEFPPAE 774
Query: 480 DQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASS 539
Q +P + P +Q S M R + +
Sbjct: 775 AQ----------APDQTDSSGQKKPDPFKIWAQSRS----MYENRLPDYQEQDIFLWRKE 820
Query: 540 TVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGL 599
T GFG ++ GG P + I P A+ G
Sbjct: 821 T-----------------------GFGFRILGG----NEPGEPIYIGHIVPLGAADTDGR 853
Query: 600 LQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDV------AESVIPSSGT 653
L+ GD ++ ++G + + QL++ AA V L V V E+ +PS +
Sbjct: 854 LRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPAS 913
Query: 654 FH------VKLPKKRSVELGI-----TISSASR--------------------------- 675
H L +++ G T+SS S
Sbjct: 914 SHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 973
Query: 676 KRGEP-----LIISDIKK-----------------------GSVAHRTGTLEPGDKLLAI 707
+RGE +I+S + + GS A R G L+ GD++LA+
Sbjct: 974 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1033
Query: 708 DNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVS--------------- 752
+ + N D V ++++ + V L+I +++S+ T A
Sbjct: 1034 NGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGT 1093
Query: 753 ----------------------------YTVELKRYGGPLGITISGTEEPFDPIVISGLT 784
YTVEL+R G ++ G E + + L
Sbjct: 1094 QETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLA 1153
Query: 785 KRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRK 844
+ G AER G + +GD IL IN + K S AI L++ G V L +K R
Sbjct: 1154 EDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLK---------RG 1204
Query: 845 SGSLSETSDADEDPADAL-KGGLPAARFSP---AVPSVDSA 881
GS+ E + + A G+P R P PS++S+
Sbjct: 1205 DGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESS 1245
Score = 38.9 bits (89), Expect = 0.028
Identities = 32/138 (23%), Positives = 56/138 (40%), Gaps = 5/138 (3%)
Query: 765 GITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVA 824
G I G EP +PI I + G A+ G + GD ++ ++ + G+ + L+Q A
Sbjct: 824 GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 883
Query: 825 GE----TVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDS 880
+ +T++ K P + S + + + PA + ++ +V S
Sbjct: 884 AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSS 943
Query: 881 AVESWDSSATEGGFGGPG 898
S S GG GG G
Sbjct: 944 GSGS-TSGIGSGGGGGSG 960
Score = 38.1 bits (87), Expect = 0.048
Identities = 38/167 (22%), Positives = 68/167 (40%), Gaps = 10/167 (5%)
Query: 756 ELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLS 815
+L++ G T+ G +EP + + I L G A G + GD I+++N+ + G +
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 816 EAIHLLQ--VAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPA----A 869
+ + + Q G +V L++ + P P + TS A D + G A
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
Query: 870 RFSPAVPSVDSAVESWDSS----ATEGGFGGPGSYTPQAAARGTTPQ 912
S V+ ++ SS A+ G P A++ T P+
Sbjct: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPE 640
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 77.8 bits (190), Expect = 5e-14
Identities = 124/601 (20%), Positives = 214/601 (35%), Gaps = 108/601 (17%)
Query: 245 DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPL 304
+V L K NS G + GG + V + P G A+ +G + GDR+L+V+G+ L
Sbjct: 1177 EVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVI-PQGAAESDGRIHKGDRVLAVNGVSL 1235
Query: 305 HGASHATALATLRQCSH---------EALFQVEYDVATPDTVA---NASGPLMVEIVKTP 352
GA+H A+ TLR ++ E+ TP NA G ++ KT
Sbjct: 1236 EGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTT 1295
Query: 353 ---------------------GSALGISLTTTSLR-----NKSVITIDRIKPASVVDRSG 386
S LG S + N S++ + ++ P SG
Sbjct: 1296 QVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1355
Query: 387 ALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRL-------EILP------------ 427
+ GD IL ++G S++ S E L + +V L +LP
Sbjct: 1356 KIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQS 1415
Query: 428 ----VPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPR------------------- 464
+P S + V + S++ D C SP
Sbjct: 1416 PAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTA 1475
Query: 465 PGHCRMPTWATPAGQDQSRSLSSTP--FSSPTLNHAFSC----------NNPSTLPRGSQ 512
P + TW++ Q S +S +P C N P
Sbjct: 1476 PANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPS 1535
Query: 513 PMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVL--CGDPLSGFGLQLQ 570
P+ P G+ Q + E SS S+ + + E + + L F L+++
Sbjct: 1536 PLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVE 1595
Query: 571 ----------GGIFATETLSSPPLVCFIEP--DSPAERCGLLQVGDRVLSINGIATEDGT 618
G + T T + + C++ PA+ G L+ GDR++ +N + T
Sbjct: 1596 LLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMT 1655
Query: 619 MEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRG 678
+A LLR A+ ++V+ ++ + + L + ELG ++
Sbjct: 1656 HTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1714
Query: 679 EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKD 738
+ + ISDI SVA G L+ D + ++ + +E+ + L + LK ++
Sbjct: 1715 QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRN 1774
Query: 739 E 739
+
Sbjct: 1775 D 1775
Score = 67.8 bits (164), Expect = 6e-11
Identities = 121/533 (22%), Positives = 190/533 (35%), Gaps = 104/533 (19%)
Query: 246 VSLYKEGN-SFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPL 304
V+L K+ GF + GG + G + ++ V PGGPAD +G LK GDRL+SV+ + L
Sbjct: 903 VNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 961
Query: 305 HGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTS 364
G SH A+ L+ P+ V +I K P + + ++ +
Sbjct: 962 EGVSHHAAIEILQN--------------APEDVTLVISQPKEKISKVPSTPVHLTNEMKN 1007
Query: 365 LRNKSVITIDRIKPASVVDRSGALHPGDH--ILSIDGTSMEHCSLLEATKLLASISEKVR 422
KS D S +D S H + I S L L S+ R
Sbjct: 1008 YMKKSSYMQD-----SAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSL---SSQDSR 1059
Query: 423 LEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQS 482
E + QSQ + E H SP P T D +
Sbjct: 1060 TESASLSQSQVNGFFASHLGDQTWQESQH---------GSPSPSVISKAT-EKETFTDSN 1109
Query: 483 RSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSL------ 536
+S + P S +++ RG M T + + + +SS S+
Sbjct: 1110 QSKTKKPGISDVTDYS---------DRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKM 1160
Query: 537 -----ASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPD 591
+SS PG + EV L + + G+ + GG+ T V + P
Sbjct: 1161 NFKTFSSSPPKPG------DIFEVELAKND-NSLGISVTGGV-NTSVRHGGIYVKAVIPQ 1212
Query: 592 SPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAE------ 645
AE G + GDRVL++NG++ E T ++A + LR+ ++LE
Sbjct: 1213 GAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPV 1272
Query: 646 ----------------------------SVIPSSGTFHVKLPKKRSVELGITISSASRKR 677
S + TF VKL K S LG + S
Sbjct: 1273 TPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKL-FKNSSGLGFSFSREDNLI 1331
Query: 678 GEPLIISDIK-----KGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILR 725
E + S ++ G A +G ++ GD +L ++ L ++ + LR
Sbjct: 1332 PEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384
Score = 65.5 bits (158), Expect = 3e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 43/227 (18%)
Query: 135 SIPEEFRGITVVELIKKEGSTLGLTISGGTD---KDGKPRVSNLRPGGLAARSDLLNIGD 191
S P + I VEL K + S LG++++GG + + G V + P G A ++ GD
Sbjct: 1167 SSPPKPGDIFEVELAKNDNS-LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGD 1225
Query: 192 YIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPEN---------------- 235
+ +VNG+ L H + + L+N G+ V L +E P + E+
Sbjct: 1226 RVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQG 1285
Query: 236 -NPRIISKTV--------------DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVR- 279
P + KT +V L+K + GF + ED + + VR
Sbjct: 1286 QGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSF---SREDNLIPEQINASIVRV 1342
Query: 280 ----PGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHE 322
PG PA G + VGD +L V+G L G S ++ LR + E
Sbjct: 1343 KKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE 1389
Score = 62.4 bits (150), Expect = 2e-09
Identities = 130/555 (23%), Positives = 195/555 (35%), Gaps = 110/555 (19%)
Query: 638 EVEFDVAESVIPSSGT-FHVKLPKKRSVELGITIS---SASRKRGEPLIISDIKKGSVAH 693
++ F S P G F V+L K + LGI+++ + S + G + + I +G+ A
Sbjct: 1159 KMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVNTSVRHGGIYVKAVIPQGA-AE 1216
Query: 694 RTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDE--------- 744
G + GD++LA++ + L+ + AV+ LR +V L + K + + +
Sbjct: 1217 SDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQC 1276
Query: 745 ---------------LETTGAVSY-------TVELKRYGGPLGITISGTEEP-------- 774
+TT Y T E+K + G+ S + E
Sbjct: 1277 TLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQIN 1336
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ + L A +G I VGD IL +N SLKG E I L+ V L
Sbjct: 1337 ASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLL--- 1393
Query: 835 QLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPS-VDSAVES--------- 884
L RP G L E A P + LP + + PS V+ + S
Sbjct: 1394 -LCRP----PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKS 1448
Query: 885 ---------WDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGS--------PPPTE 927
DS + G G T A +T L P
Sbjct: 1449 KKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKS 1508
Query: 928 PRRTSYTPTPADESFPEEEEEDDWEP---PTSPAPGPAREEGFWRMFGEALEDLESCGQS 984
T T + P + E +D P P APG + + ES S
Sbjct: 1509 QEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQP-----------QSESASSS 1557
Query: 985 ELLRELEASIMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHK 1044
+ + I T Q P + E E+E LL T ++ K +L
Sbjct: 1558 SMDKYHIHHISEPTRQE-------NWTPLKNDLENHLEDFELEVELLITLIKSEKGSL-- 1608
Query: 1045 DPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVP 1104
GF+V+ G G YVH V D G L+P DR+++VN + AV
Sbjct: 1609 -------GFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1661
Query: 1105 LLAEAGDVLELIISR 1119
LL A + L+I R
Sbjct: 1662 LLRAASKTVRLVIGR 1676
Score = 54.3 bits (129), Expect = 6e-07
Identities = 104/449 (23%), Positives = 164/449 (36%), Gaps = 82/449 (18%)
Query: 720 AVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKR---YGGPLGITISGTEEPFD 776
A Q + +D+ L R +S E E T V LK+ YG LG I G E+
Sbjct: 873 ARQSNQDAQDIDVLHKRWSIVSSPEREIT-----LVNLKKDAKYG--LGFQIIGGEKMGR 925
Query: 777 ---PIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIK 833
I IS + G A+ G + GDR++++N+VSL+G AI +LQ A E VTL I
Sbjct: 926 LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVIS 985
Query: 834 KQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVES------WDS 887
+ ++ +S+ + +K + + + DSA++S W
Sbjct: 986 QPKEK---------ISKVPSTPVHLTNEMKNYMKKSSYMQ-----DSAIDSSSKDHHWSR 1031
Query: 888 SA----TEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFP 943
+E FG G R G L TE S + + + F
Sbjct: 1032 GTLRHISENSFGPSGGL--------------REGSLSSQDSRTE--SASLSQSQVNGFFA 1075
Query: 944 EEEEEDDWEPPTSPAPGP-----AREEGFWRMFGEA---------LEDLESCGQSELLRE 989
+ W+ +P P A E+ + ++ + D G S++
Sbjct: 1076 SHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEA 1135
Query: 990 LEASIMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRH 1049
+S + + +SP P P ++ +V L K+ +
Sbjct: 1136 TYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSP--------PKPGDIFEVELAKND--N 1185
Query: 1050 DFGFSVSDG----LLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAVP 1104
G SV+ G + G+YV V P G A G + DRVL VN V AV
Sbjct: 1186 SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE 1245
Query: 1105 LLAEAGDVLELIISRKPHTAHSSRAPRSP 1133
L G V+ L++ + P +P
Sbjct: 1246 TLRNTGQVVHLLLEKGQSPTSKEHVPVTP 1274
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/193 (24%), Positives = 88/193 (45%), Gaps = 6/193 (3%)
Query: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715
+ L K LG T++ +++ G + D+ + A G L+PGD+L+ +++ + N
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQRIG--CYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1654
Query: 716 PMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEP- 774
DAV +LR V+L I + + + + + L LG ++ G +
Sbjct: 1655 THTDAVNLLRAASKTVRLVIGRVLE-LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSL 1713
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ + IS + R +A G + + D I +N VS +G L E L ++ ++ LK +
Sbjct: 1714 YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATR 1773
Query: 835 QLDRPLLPRKSGS 847
D P++P S
Sbjct: 1774 N-DLPVVPSSKRS 1785
Score = 45.8 bits (107), Expect = 2e-04
Identities = 43/163 (26%), Positives = 77/163 (47%), Gaps = 10/163 (6%)
Query: 145 VVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSD-LLNIGDYIRSVNGIHLTR 203
++ LIK E +LG T++ G + G ++ A+SD L GD + VN +T
Sbjct: 1597 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQD---PAKSDGRLKPGDRLIKVNDTDVTN 1653
Query: 204 LRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGA 263
+ H + + LL+ + V L + L P P ++ D++L GF L GG
Sbjct: 1654 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLP---DITLTCNKEELGFSLCGG- 1709
Query: 264 HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHG 306
H+ + + + ++ + P A EG+L++ D + V+G+ G
Sbjct: 1710 HDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQG 1750
Score = 45.1 bits (105), Expect = 4e-04
Identities = 36/142 (25%), Positives = 66/142 (46%), Gaps = 10/142 (7%)
Query: 621 EANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASR--KRG 678
++NQ +D + HK + + S P V L K LG I + +
Sbjct: 875 QSNQDAQDIDVLHK-----RWSIVSS--PEREITLVNLKKDAKYGLGFQIIGGEKMGRLD 927
Query: 679 EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKD 738
+ IS + G A G L+PGD+L++++++ L+ A++IL+ + V L I +
Sbjct: 928 LGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQP 987
Query: 739 EDNSDELETTGAVSYTVELKRY 760
++ ++ +T V T E+K Y
Sbjct: 988 KEKISKVPST-PVHLTNEMKNY 1008
Score = 43.9 bits (102), Expect = 9e-04
Identities = 38/106 (35%), Positives = 53/106 (50%), Gaps = 10/106 (9%)
Query: 126 DVSLACRRQSI---PEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPR----VSNLRPG 178
D+ + +R SI PE R IT+V L K LG I GG +K G+ +S++ PG
Sbjct: 882 DIDVLHKRWSIVSSPE--REITLVNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPG 938
Query: 179 GLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV 224
G A L GD + SVN + L + H I +L+N E V L +
Sbjct: 939 GPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 984
Score = 39.7 bits (91), Expect = 0.017
Identities = 24/71 (33%), Positives = 35/71 (49%)
Query: 171 RVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPP 230
RV L PG AA S +++GD I VNG L L E+I+ L+ V L + P
Sbjct: 1341 RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG 1400
Query: 231 PAPENNPRIIS 241
PE + +++
Sbjct: 1401 VLPEIDTALLT 1411
Score = 38.9 bits (89), Expect = 0.028
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 551 ETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIE---PDSPAERCGLLQVGDRVL 607
E T V L D G G Q+ GG E + L FI P PA+ G L+ GDR++
Sbjct: 899 EITLVNLKKDAKYGLGFQIIGG----EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 954
Query: 608 SINGIATEDGTMEEANQLLRDA 629
S+N ++ E + A ++L++A
Sbjct: 955 SVNSVSLEGVSHHAAIEILQNA 976
Score = 38.5 bits (88), Expect = 0.037
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 6/110 (5%)
Query: 566 GLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
G L GG ++L + I P S A G LQ+ D + +NG++T+ T+EE N+
Sbjct: 1703 GFSLCGG---HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1759
Query: 626 LRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASR 675
L D +L V+ D+ V+PSS V PK ++ S S+
Sbjct: 1760 L-DMSLPSLVLKATRNDL--PVVPSSKRSAVSAPKSTKGNGSYSVGSCSQ 1806
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 77.8 bits (190), Expect = 5e-14
Identities = 124/601 (20%), Positives = 214/601 (35%), Gaps = 108/601 (17%)
Query: 245 DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPL 304
+V L K NS G + GG + V + P G A+ +G + GDR+L+V+G+ L
Sbjct: 1368 EVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVI-PQGAAESDGRIHKGDRVLAVNGVSL 1426
Query: 305 HGASHATALATLRQCSH---------EALFQVEYDVATPDTVA---NASGPLMVEIVKTP 352
GA+H A+ TLR ++ E+ TP NA G ++ KT
Sbjct: 1427 EGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTT 1486
Query: 353 ---------------------GSALGISLTTTSLR-----NKSVITIDRIKPASVVDRSG 386
S LG S + N S++ + ++ P SG
Sbjct: 1487 QVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1546
Query: 387 ALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRL-------EILP------------ 427
+ GD IL ++G S++ S E L + +V L +LP
Sbjct: 1547 KIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQS 1606
Query: 428 ----VPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPR------------------- 464
+P S + V + S++ D C SP
Sbjct: 1607 PAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTA 1666
Query: 465 PGHCRMPTWATPAGQDQSRSLSSTP--FSSPTLNHAFSC----------NNPSTLPRGSQ 512
P + TW++ Q S +S +P C N P
Sbjct: 1667 PANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPS 1726
Query: 513 PMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVL--CGDPLSGFGLQLQ 570
P+ P G+ Q + E SS S+ + + E + + L F L+++
Sbjct: 1727 PLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVE 1786
Query: 571 ----------GGIFATETLSSPPLVCFIEP--DSPAERCGLLQVGDRVLSINGIATEDGT 618
G + T T + + C++ PA+ G L+ GDR++ +N + T
Sbjct: 1787 LLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMT 1846
Query: 619 MEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRG 678
+A LLR A+ ++V+ ++ + + L + ELG ++
Sbjct: 1847 HTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1905
Query: 679 EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKD 738
+ + ISDI SVA G L+ D + ++ + +E+ + L + LK ++
Sbjct: 1906 QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRN 1965
Query: 739 E 739
+
Sbjct: 1966 D 1966
Score = 67.8 bits (164), Expect = 6e-11
Identities = 121/533 (22%), Positives = 190/533 (35%), Gaps = 104/533 (19%)
Query: 246 VSLYKEGN-SFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPL 304
V+L K+ GF + GG + G + ++ V PGGPAD +G LK GDRL+SV+ + L
Sbjct: 1094 VNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152
Query: 305 HGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTS 364
G SH A+ L+ P+ V +I K P + + ++ +
Sbjct: 1153 EGVSHHAAIEILQN--------------APEDVTLVISQPKEKISKVPSTPVHLTNEMKN 1198
Query: 365 LRNKSVITIDRIKPASVVDRSGALHPGDH--ILSIDGTSMEHCSLLEATKLLASISEKVR 422
KS D S +D S H + I S L L S+ R
Sbjct: 1199 YMKKSSYMQD-----SAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSL---SSQDSR 1250
Query: 423 LEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQS 482
E + QSQ + E H SP P T D +
Sbjct: 1251 TESASLSQSQVNGFFASHLGDQTWQESQH---------GSPSPSVISKAT-EKETFTDSN 1300
Query: 483 RSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSL------ 536
+S + P S +++ RG M T + + + +SS S+
Sbjct: 1301 QSKTKKPGISDVTDYS---------DRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKM 1351
Query: 537 -----ASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPD 591
+SS PG + EV L + + G+ + GG+ T V + P
Sbjct: 1352 NFKTFSSSPPKPG------DIFEVELAKND-NSLGISVTGGV-NTSVRHGGIYVKAVIPQ 1403
Query: 592 SPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAE------ 645
AE G + GDRVL++NG++ E T ++A + LR+ ++LE
Sbjct: 1404 GAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPV 1463
Query: 646 ----------------------------SVIPSSGTFHVKLPKKRSVELGITISSASRKR 677
S + TF VKL K S LG + S
Sbjct: 1464 TPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKL-FKNSSGLGFSFSREDNLI 1522
Query: 678 GEPLIISDIK-----KGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILR 725
E + S ++ G A +G ++ GD +L ++ L ++ + LR
Sbjct: 1523 PEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575
Score = 65.5 bits (158), Expect = 3e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 43/227 (18%)
Query: 135 SIPEEFRGITVVELIKKEGSTLGLTISGGTD---KDGKPRVSNLRPGGLAARSDLLNIGD 191
S P + I VEL K + S LG++++GG + + G V + P G A ++ GD
Sbjct: 1358 SSPPKPGDIFEVELAKNDNS-LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGD 1416
Query: 192 YIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPEN---------------- 235
+ +VNG+ L H + + L+N G+ V L +E P + E+
Sbjct: 1417 RVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQG 1476
Query: 236 -NPRIISKTV--------------DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVR- 279
P + KT +V L+K + GF + ED + + VR
Sbjct: 1477 QGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSF---SREDNLIPEQINASIVRV 1533
Query: 280 ----PGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHE 322
PG PA G + VGD +L V+G L G S ++ LR + E
Sbjct: 1534 KKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE 1580
Score = 62.4 bits (150), Expect = 2e-09
Identities = 130/555 (23%), Positives = 195/555 (35%), Gaps = 110/555 (19%)
Query: 638 EVEFDVAESVIPSSGT-FHVKLPKKRSVELGITIS---SASRKRGEPLIISDIKKGSVAH 693
++ F S P G F V+L K + LGI+++ + S + G + + I +G+ A
Sbjct: 1350 KMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVNTSVRHGGIYVKAVIPQGA-AE 1407
Query: 694 RTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDE--------- 744
G + GD++LA++ + L+ + AV+ LR +V L + K + + +
Sbjct: 1408 SDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQC 1467
Query: 745 ---------------LETTGAVSY-------TVELKRYGGPLGITISGTEEP-------- 774
+TT Y T E+K + G+ S + E
Sbjct: 1468 TLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQIN 1527
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ + L A +G I VGD IL +N SLKG E I L+ V L
Sbjct: 1528 ASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLL--- 1584
Query: 835 QLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPS-VDSAVES--------- 884
L RP G L E A P + LP + + PS V+ + S
Sbjct: 1585 -LCRP----PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKS 1639
Query: 885 ---------WDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGS--------PPPTE 927
DS + G G T A +T L P
Sbjct: 1640 KKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKS 1699
Query: 928 PRRTSYTPTPADESFPEEEEEDDWEP---PTSPAPGPAREEGFWRMFGEALEDLESCGQS 984
T T + P + E +D P P APG + + ES S
Sbjct: 1700 QEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQP-----------QSESASSS 1748
Query: 985 ELLRELEASIMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHK 1044
+ + I T Q P + E E+E LL T ++ K +L
Sbjct: 1749 SMDKYHIHHISEPTRQE-------NWTPLKNDLENHLEDFELEVELLITLIKSEKGSL-- 1799
Query: 1045 DPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVP 1104
GF+V+ G G YVH V D G L+P DR+++VN + AV
Sbjct: 1800 -------GFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1852
Query: 1105 LLAEAGDVLELIISR 1119
LL A + L+I R
Sbjct: 1853 LLRAASKTVRLVIGR 1867
Score = 53.9 bits (128), Expect = 8e-07
Identities = 85/385 (22%), Positives = 139/385 (36%), Gaps = 69/385 (17%)
Query: 778 IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLD 837
I IS + G A+ G + GDR++++N+VSL+G AI +LQ A E VTL I + +
Sbjct: 1121 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Query: 838 RPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVES------WDSSA-- 889
+ +S+ + +K + + + DSA++S W
Sbjct: 1181 K---------ISKVPSTPVHLTNEMKNYMKKSSYMQ-----DSAIDSSSKDHHWSRGTLR 1226
Query: 890 --TEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEEE 947
+E FG G R G L TE S + + + F
Sbjct: 1227 HISENSFGPSGGL--------------REGSLSSQDSRTE--SASLSQSQVNGFFASHLG 1270
Query: 948 EDDWEPPTSPAPGP-----AREEGFWRMFGEA---------LEDLESCGQSELLRELEAS 993
+ W+ +P P A E+ + ++ + D G S++ +S
Sbjct: 1271 DQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSS 1330
Query: 994 IMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGF 1053
+ + +SP P P ++ +V L K+ + G
Sbjct: 1331 SQDHQTPKQESSSSVNTSNKMNFKTFSSSP--------PKPGDIFEVELAKND--NSLGI 1380
Query: 1054 SVSDG----LLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAVPLLAE 1108
SV+ G + G+YV V P G A G + DRVL VN V AV L
Sbjct: 1381 SVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN 1440
Query: 1109 AGDVLELIISRKPHTAHSSRAPRSP 1133
G V+ L++ + P +P
Sbjct: 1441 TGQVVHLLLEKGQSPTSKEHVPVTP 1465
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/193 (24%), Positives = 88/193 (45%), Gaps = 6/193 (3%)
Query: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715
+ L K LG T++ +++ G + D+ + A G L+PGD+L+ +++ + N
Sbjct: 1789 ITLIKSEKGSLGFTVTKGNQRIG--CYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1845
Query: 716 PMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEP- 774
DAV +LR V+L I + + + + + L LG ++ G +
Sbjct: 1846 THTDAVNLLRAASKTVRLVIGRVLE-LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSL 1904
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ + IS + R +A G + + D I +N VS +G L E L ++ ++ LK +
Sbjct: 1905 YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATR 1964
Query: 835 QLDRPLLPRKSGS 847
D P++P S
Sbjct: 1965 N-DLPVVPSSKRS 1976
Score = 45.8 bits (107), Expect = 2e-04
Identities = 43/163 (26%), Positives = 77/163 (47%), Gaps = 10/163 (6%)
Query: 145 VVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSD-LLNIGDYIRSVNGIHLTR 203
++ LIK E +LG T++ G + G ++ A+SD L GD + VN +T
Sbjct: 1788 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQD---PAKSDGRLKPGDRLIKVNDTDVTN 1844
Query: 204 LRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGA 263
+ H + + LL+ + V L + L P P ++ D++L GF L GG
Sbjct: 1845 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLP---DITLTCNKEELGFSLCGG- 1900
Query: 264 HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHG 306
H+ + + + ++ + P A EG+L++ D + V+G+ G
Sbjct: 1901 HDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQG 1941
Score = 45.4 bits (106), Expect = 3e-04
Identities = 36/145 (24%), Positives = 63/145 (43%), Gaps = 5/145 (3%)
Query: 618 TMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASR-- 675
TM + L VL + + S P V L K LG I +
Sbjct: 1058 TMHSSGNSSSQVPLKENDVLHKRWSIVSS--PEREITLVNLKKDAKYGLGFQIIGGEKMG 1115
Query: 676 KRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKI 735
+ + IS + G A G L+PGD+L++++++ L+ A++IL+ + V L I
Sbjct: 1116 RLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
Query: 736 RKDEDNSDELETTGAVSYTVELKRY 760
+ ++ ++ +T V T E+K Y
Sbjct: 1176 SQPKEKISKVPST-PVHLTNEMKNY 1199
Score = 43.9 bits (102), Expect = 9e-04
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 8/103 (7%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDG----LLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVN 1090
E+ V L KD ++ GF + G L+ G+++ +V P GPA G L+P DR++ VN
Sbjct: 1090 EITLVNLKKDA-KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1148
Query: 1091 HVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSP 1133
V A+ +L A + + L+IS+ S+ P +P
Sbjct: 1149 SVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKI--SKVPSTP 1189
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 7/94 (7%)
Query: 135 SIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPR----VSNLRPGGLAARSDLLNIG 190
S PE R IT+V L K LG I GG +K G+ +S++ PGG A L G
Sbjct: 1085 SSPE--REITLVNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141
Query: 191 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV 224
D + SVN + L + H I +L+N E V L +
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
Score = 39.7 bits (91), Expect = 0.017
Identities = 24/71 (33%), Positives = 35/71 (49%)
Query: 171 RVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPP 230
RV L PG AA S +++GD I VNG L L E+I+ L+ V L + P
Sbjct: 1532 RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG 1591
Query: 231 PAPENNPRIIS 241
PE + +++
Sbjct: 1592 VLPEIDTALLT 1602
Score = 38.9 bits (89), Expect = 0.028
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 551 ETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIE---PDSPAERCGLLQVGDRVL 607
E T V L D G G Q+ GG E + L FI P PA+ G L+ GDR++
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIGG----EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 1145
Query: 608 SINGIATEDGTMEEANQLLRDA 629
S+N ++ E + A ++L++A
Sbjct: 1146 SVNSVSLEGVSHHAAIEILQNA 1167
Score = 38.5 bits (88), Expect = 0.037
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 6/110 (5%)
Query: 566 GLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
G L GG ++L + I P S A G LQ+ D + +NG++T+ T+EE N+
Sbjct: 1894 GFSLCGG---HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1950
Query: 626 LRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASR 675
L D +L V+ D+ V+PSS V PK ++ S S+
Sbjct: 1951 L-DMSLPSLVLKATRNDL--PVVPSSKRSAVSAPKSTKGNGSYSVGSCSQ 1997
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 77.8 bits (190), Expect = 5e-14
Identities = 124/601 (20%), Positives = 214/601 (35%), Gaps = 108/601 (17%)
Query: 245 DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPL 304
+V L K NS G + GG + V + P G A+ +G + GDR+L+V+G+ L
Sbjct: 1349 EVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVI-PQGAAESDGRIHKGDRVLAVNGVSL 1407
Query: 305 HGASHATALATLRQCSH---------EALFQVEYDVATPDTVA---NASGPLMVEIVKTP 352
GA+H A+ TLR ++ E+ TP NA G ++ KT
Sbjct: 1408 EGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTT 1467
Query: 353 ---------------------GSALGISLTTTSLR-----NKSVITIDRIKPASVVDRSG 386
S LG S + N S++ + ++ P SG
Sbjct: 1468 QVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1527
Query: 387 ALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRL-------EILP------------ 427
+ GD IL ++G S++ S E L + +V L +LP
Sbjct: 1528 KIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQS 1587
Query: 428 ----VPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPR------------------- 464
+P S + V + S++ D C SP
Sbjct: 1588 PAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTA 1647
Query: 465 PGHCRMPTWATPAGQDQSRSLSSTP--FSSPTLNHAFSC----------NNPSTLPRGSQ 512
P + TW++ Q S +S +P C N P
Sbjct: 1648 PANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPS 1707
Query: 513 PMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVL--CGDPLSGFGLQLQ 570
P+ P G+ Q + E SS S+ + + E + + L F L+++
Sbjct: 1708 PLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVE 1767
Query: 571 ----------GGIFATETLSSPPLVCFIEP--DSPAERCGLLQVGDRVLSINGIATEDGT 618
G + T T + + C++ PA+ G L+ GDR++ +N + T
Sbjct: 1768 LLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMT 1827
Query: 619 MEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRG 678
+A LLR A+ ++V+ ++ + + L + ELG ++
Sbjct: 1828 HTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1886
Query: 679 EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKD 738
+ + ISDI SVA G L+ D + ++ + +E+ + L + LK ++
Sbjct: 1887 QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRN 1946
Query: 739 E 739
+
Sbjct: 1947 D 1947
Score = 70.5 bits (171), Expect = 9e-12
Identities = 127/577 (22%), Positives = 208/577 (36%), Gaps = 110/577 (19%)
Query: 203 RLRHDEIITLLKNVGERVVLEVEYELPP--PAPENNPRIISKTVDVSLYKEGNSFGFVLR 260
R +H+ + +++ G+ VL+V ++ +PE +++ D GF +
Sbjct: 1036 RRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKY-----GLGFQII 1090
Query: 261 GGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
GG + G + ++ V PGGPAD +G LK GDRL+SV+ + L G SH A+ L+
Sbjct: 1091 GG-EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQN-- 1147
Query: 321 HEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPAS 380
P+ V +I K P + + ++ + KS D S
Sbjct: 1148 ------------APEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQD-----S 1190
Query: 381 VVDRSGALHPGDH--ILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQ 438
+D S H + I S L L S+ R E + QSQ
Sbjct: 1191 AIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSL---SSQDSRTESASLSQSQVNGFFA 1247
Query: 439 RQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHA 498
+ E H SP P T D ++S + P S +++
Sbjct: 1248 SHLGDQTWQESQH---------GSPSPSVISKAT-EKETFTDSNQSKTKKPGISDVTDYS 1297
Query: 499 FSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSL-----------ASSTVGPGGQI 547
RG M T + + + +SS S+ +SS PG
Sbjct: 1298 ---------DRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPG--- 1345
Query: 548 VHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVL 607
+ EV L + + G+ + GG+ T V + P AE G + GDRVL
Sbjct: 1346 ---DIFEVELAKND-NSLGISVTGGV-NTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 1400
Query: 608 SINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAE---------------------- 645
++NG++ E T ++A + LR+ ++LE
Sbjct: 1401 AVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGP 1460
Query: 646 ------------SVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIK-----K 688
S + TF VKL K S LG + S E + S ++
Sbjct: 1461 EKVKKTTQVKDYSFVTEENTFEVKL-FKNSSGLGFSFSREDNLIPEQINASIVRVKKLFP 1519
Query: 689 GSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILR 725
G A +G ++ GD +L ++ L ++ + LR
Sbjct: 1520 GQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556
Score = 65.5 bits (158), Expect = 3e-10
Identities = 61/227 (26%), Positives = 95/227 (41%), Gaps = 43/227 (18%)
Query: 135 SIPEEFRGITVVELIKKEGSTLGLTISGGTD---KDGKPRVSNLRPGGLAARSDLLNIGD 191
S P + I VEL K + S LG++++GG + + G V + P G A ++ GD
Sbjct: 1339 SSPPKPGDIFEVELAKNDNS-LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGD 1397
Query: 192 YIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPEN---------------- 235
+ +VNG+ L H + + L+N G+ V L +E P + E+
Sbjct: 1398 RVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQG 1457
Query: 236 -NPRIISKTV--------------DVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVR- 279
P + KT +V L+K + GF + ED + + VR
Sbjct: 1458 QGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSF---SREDNLIPEQINASIVRV 1514
Query: 280 ----PGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHE 322
PG PA G + VGD +L V+G L G S ++ LR + E
Sbjct: 1515 KKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE 1561
Score = 62.4 bits (150), Expect = 2e-09
Identities = 130/555 (23%), Positives = 195/555 (35%), Gaps = 110/555 (19%)
Query: 638 EVEFDVAESVIPSSGT-FHVKLPKKRSVELGITIS---SASRKRGEPLIISDIKKGSVAH 693
++ F S P G F V+L K + LGI+++ + S + G + + I +G+ A
Sbjct: 1331 KMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVNTSVRHGGIYVKAVIPQGA-AE 1388
Query: 694 RTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDE--------- 744
G + GD++LA++ + L+ + AV+ LR +V L + K + + +
Sbjct: 1389 SDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQC 1448
Query: 745 ---------------LETTGAVSY-------TVELKRYGGPLGITISGTEEP-------- 774
+TT Y T E+K + G+ S + E
Sbjct: 1449 TLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQIN 1508
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ + L A +G I VGD IL +N SLKG E I L+ V L
Sbjct: 1509 ASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLL--- 1565
Query: 835 QLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPS-VDSAVES--------- 884
L RP G L E A P + LP + + PS V+ + S
Sbjct: 1566 -LCRP----PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKS 1620
Query: 885 ---------WDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGS--------PPPTE 927
DS + G G T A +T L P
Sbjct: 1621 KKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKS 1680
Query: 928 PRRTSYTPTPADESFPEEEEEDDWEP---PTSPAPGPAREEGFWRMFGEALEDLESCGQS 984
T T + P + E +D P P APG + + ES S
Sbjct: 1681 QEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQP-----------QSESASSS 1729
Query: 985 ELLRELEASIMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHK 1044
+ + I T Q P + E E+E LL T ++ K +L
Sbjct: 1730 SMDKYHIHHISEPTRQE-------NWTPLKNDLENHLEDFELEVELLITLIKSEKGSL-- 1780
Query: 1045 DPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVP 1104
GF+V+ G G YVH V D G L+P DR+++VN + AV
Sbjct: 1781 -------GFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1833
Query: 1105 LLAEAGDVLELIISR 1119
LL A + L+I R
Sbjct: 1834 LLRAASKTVRLVIGR 1848
Score = 53.9 bits (128), Expect = 8e-07
Identities = 85/385 (22%), Positives = 139/385 (36%), Gaps = 69/385 (17%)
Query: 778 IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLD 837
I IS + G A+ G + GDR++++N+VSL+G AI +LQ A E VTL I + +
Sbjct: 1102 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1161
Query: 838 RPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVES------WDSSA-- 889
+ +S+ + +K + + + DSA++S W
Sbjct: 1162 K---------ISKVPSTPVHLTNEMKNYMKKSSYMQ-----DSAIDSSSKDHHWSRGTLR 1207
Query: 890 --TEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEEE 947
+E FG G R G L TE S + + + F
Sbjct: 1208 HISENSFGPSGGL--------------REGSLSSQDSRTE--SASLSQSQVNGFFASHLG 1251
Query: 948 EDDWEPPTSPAPGP-----AREEGFWRMFGEA---------LEDLESCGQSELLRELEAS 993
+ W+ +P P A E+ + ++ + D G S++ +S
Sbjct: 1252 DQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSS 1311
Query: 994 IMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGF 1053
+ + +SP P P ++ +V L K+ + G
Sbjct: 1312 SQDHQTPKQESSSSVNTSNKMNFKTFSSSP--------PKPGDIFEVELAKND--NSLGI 1361
Query: 1054 SVSDG----LLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAVPLLAE 1108
SV+ G + G+YV V P G A G + DRVL VN V AV L
Sbjct: 1362 SVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN 1421
Query: 1109 AGDVLELIISRKPHTAHSSRAPRSP 1133
G V+ L++ + P +P
Sbjct: 1422 TGQVVHLLLEKGQSPTSKEHVPVTP 1446
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/193 (24%), Positives = 88/193 (45%), Gaps = 6/193 (3%)
Query: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715
+ L K LG T++ +++ G + D+ + A G L+PGD+L+ +++ + N
Sbjct: 1770 ITLIKSEKGSLGFTVTKGNQRIG--CYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1826
Query: 716 PMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEP- 774
DAV +LR V+L I + + + + + L LG ++ G +
Sbjct: 1827 THTDAVNLLRAASKTVRLVIGRVLE-LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSL 1885
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ + IS + R +A G + + D I +N VS +G L E L ++ ++ LK +
Sbjct: 1886 YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATR 1945
Query: 835 QLDRPLLPRKSGS 847
D P++P S
Sbjct: 1946 N-DLPVVPSSKRS 1957
Score = 45.8 bits (107), Expect = 2e-04
Identities = 43/163 (26%), Positives = 77/163 (47%), Gaps = 10/163 (6%)
Query: 145 VVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSD-LLNIGDYIRSVNGIHLTR 203
++ LIK E +LG T++ G + G ++ A+SD L GD + VN +T
Sbjct: 1769 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQD---PAKSDGRLKPGDRLIKVNDTDVTN 1825
Query: 204 LRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGA 263
+ H + + LL+ + V L + L P P ++ D++L GF L GG
Sbjct: 1826 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLP---DITLTCNKEELGFSLCGG- 1881
Query: 264 HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHG 306
H+ + + + ++ + P A EG+L++ D + V+G+ G
Sbjct: 1882 HDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQG 1922
Score = 43.9 bits (102), Expect = 9e-04
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 8/103 (7%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDG----LLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVN 1090
E+ V L KD ++ GF + G L+ G+++ +V P GPA G L+P DR++ VN
Sbjct: 1071 EITLVNLKKDA-KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1129
Query: 1091 HVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSP 1133
V A+ +L A + + L+IS+ S+ P +P
Sbjct: 1130 SVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKI--SKVPSTP 1170
Score = 43.9 bits (102), Expect = 9e-04
Identities = 29/107 (27%), Positives = 53/107 (49%), Gaps = 3/107 (2%)
Query: 656 VKLPKKRSVELGITISSASR--KRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLD 713
V L K LG I + + + IS + G A G L+PGD+L++++++ L+
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134
Query: 714 NCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRY 760
A++IL+ + V L I + ++ ++ +T V T E+K Y
Sbjct: 1135 GVSHHAAIEILQNAPEDVTLVISQPKEKISKVPST-PVHLTNEMKNY 1180
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 7/94 (7%)
Query: 135 SIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPR----VSNLRPGGLAARSDLLNIG 190
S PE R IT+V L K LG I GG +K G+ +S++ PGG A L G
Sbjct: 1066 SSPE--REITLVNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPGGPADLDGCLKPG 1122
Query: 191 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV 224
D + SVN + L + H I +L+N E V L +
Sbjct: 1123 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1156
Score = 40.8 bits (94), Expect = 0.007
Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 24/124 (19%)
Query: 523 RRQRRREHKSSLSLASSTVGPGGQIV--------------HTETTEVVLCGDPLSGFGLQ 568
R RR+H+S +SS PG V E T V L D G G Q
Sbjct: 1032 RSPERRKHESD---SSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQ 1088
Query: 569 LQGGIFATETLSSPPLVCFIE---PDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
+ GG E + L FI P PA+ G L+ GDR++S+N ++ E + A ++
Sbjct: 1089 IIGG----EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEI 1144
Query: 626 LRDA 629
L++A
Sbjct: 1145 LQNA 1148
Score = 39.7 bits (91), Expect = 0.017
Identities = 24/71 (33%), Positives = 35/71 (49%)
Query: 171 RVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPP 230
RV L PG AA S +++GD I VNG L L E+I+ L+ V L + P
Sbjct: 1513 RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG 1572
Query: 231 PAPENNPRIIS 241
PE + +++
Sbjct: 1573 VLPEIDTALLT 1583
Score = 38.5 bits (88), Expect = 0.037
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 6/110 (5%)
Query: 566 GLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
G L GG ++L + I P S A G LQ+ D + +NG++T+ T+EE N+
Sbjct: 1875 GFSLCGG---HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1931
Query: 626 LRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASR 675
L D +L V+ D+ V+PSS V PK ++ S S+
Sbjct: 1932 L-DMSLPSLVLKATRNDL--PVVPSSKRSAVSAPKSTKGNGSYSVGSCSQ 1978
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 77.4 bits (189), Expect = 7e-14
Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 33/206 (16%)
Query: 145 VVELIKKEGSTLGLTISGGTDK---DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHL 201
VV + K G +LG+T++GG D V ++ PGG+ +R + GD + +V+G+ L
Sbjct: 507 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVEL 566
Query: 202 TRLRHDEIITLLKNVGERVVLEV----EYE-----LPPPAPENN---------------- 236
T + E + LLK +VL+ EYE P A ++N
Sbjct: 567 TEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 626
Query: 237 ---PRIISKTVDVSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKV 292
PR + D+ L + S GF + GG +E+ + ++P + + G PA +G ++
Sbjct: 627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRC 685
Query: 293 GDRLLSVDGIPLHGASHATALATLRQ 318
GD LL+V+G G HA L++
Sbjct: 686 GDILLAVNGRSTSGMIHACLARLLKE 711
Score = 70.1 bits (170), Expect = 1e-11
Identities = 90/331 (27%), Positives = 136/331 (41%), Gaps = 52/331 (15%)
Query: 543 PGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQV 602
P G+I + V DP ++L GG +ET ++ I D R G L
Sbjct: 268 PDGEITSIKINRV----DPSESLSIRLVGG---SETPLVHIIIQHIYRDGVIARDGRLLP 320
Query: 603 GDRVLSINGIATEDGTMEEANQLLRD--AALAHKVVLEVEF------DVAESVIPSSGTF 654
GD +L +NG+ + A +LLR L V+ E +F ++ P +F
Sbjct: 321 GDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSF 380
Query: 655 HVKLPKKRSVE-LGITISSASRKRGEP-LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRL 712
HV L K E LGI + RK EP + I ++ G VA+R G LE D++LAI+ L
Sbjct: 381 HVILNKSSPEEQLGIKL---VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDL 437
Query: 713 DNCPMEDAVQILRQCEDLVKLKIRKD--------------EDNSDELETTGAVSYTVE-- 756
E A +++ E V L + + N G S T +
Sbjct: 438 RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 497
Query: 757 -------------LKRYGGPLGITISG--TEEPFD-PIVISGLTKRGLAERTGAIHVGDR 800
K G LG+T++G + +D PI + + G+ R G I GD
Sbjct: 498 HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDI 557
Query: 801 ILAINNVSLKGRPLSEAIHLLQVAGETVTLK 831
+L ++ V L SEA+ LL+ ++ LK
Sbjct: 558 LLNVDGVELTEVSRSEAVALLKRTSSSIVLK 588
Score = 65.5 bits (158), Expect = 3e-10
Identities = 79/330 (23%), Positives = 127/330 (38%), Gaps = 49/330 (14%)
Query: 172 VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPP 231
+ ++ G+ AR L GD I VNG+ ++ + H+ + LL+ + + L V E
Sbjct: 303 IQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFR 362
Query: 232 APENN-------PRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPA 284
+ N PR S V ++ G L E G + + V GG A
Sbjct: 363 SRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPG-----VFIFNVLDGGVA 417
Query: 285 DREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVAT----------- 333
R G L+ DR+L+++G L S +A ++ V V
Sbjct: 418 YRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGW 477
Query: 334 ---------PDTVANASGPL---------MVEIVKTPGSALGISLTTTSLRNK--SVITI 373
P +N PL +V I K PG +LG+++ + + I +
Sbjct: 478 NSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYV 537
Query: 374 DRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQR 433
++P V+ R G + GD +L++DG + S EA LL S + L+ L V + +
Sbjct: 538 ISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE- 596
Query: 434 PLRPQRQVVKVQRSEQLHRWDPCVPSCHSP 463
PQ + H P PS SP
Sbjct: 597 ---PQEDCSSPAALDSNHNMAP--PSDWSP 621
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/216 (26%), Positives = 92/216 (42%), Gaps = 48/216 (22%)
Query: 134 QSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYI 193
+S PEE GI +V + + G + N+ GG+A R L D +
Sbjct: 386 KSSPEEQLGIKLVRKVDEPGVF----------------IFNVLDGGVAYRHGQLEENDRV 429
Query: 194 RSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPE------------------- 234
++NG L + L++ RV L V ++ +P+
Sbjct: 430 LAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGE 489
Query: 235 --NNPRIISKTVD-----VSLYKE-GNSFGFVLRGGAHEDGHKS--RPLVLTYVRPGGPA 284
N P+ + T+ V++ K+ G S G + GGA H+ P+ + V PGG
Sbjct: 490 RSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGA---SHREWDLPIYVISVEPGGVI 546
Query: 285 DREGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
R+G +K GD LL+VDG+ L S + A+A L++ S
Sbjct: 547 SRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTS 582
Score = 55.5 bits (132), Expect = 3e-07
Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 9/199 (4%)
Query: 647 VIPSSGTFHVKLPK-KRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLL 705
+IP +K+ + S L I + S +II I + V R G L PGD +L
Sbjct: 266 LIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIIL 325
Query: 706 AIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDE-------DNSDELETTGAVSYTVELK 758
++ + + N P AV++LRQ ++ L + +++ + + S+ V L
Sbjct: 326 KVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILN 385
Query: 759 RYGGPLGITISGTEEPFDP-IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEA 817
+ + I + +P + I + G+A R G + DR+LAIN L+ A
Sbjct: 386 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA 445
Query: 818 IHLLQVAGETVTLKIKKQL 836
HL+Q + V L + +Q+
Sbjct: 446 AHLIQASERRVHLVVSRQV 464
Score = 44.3 bits (103), Expect = 7e-04
Identities = 39/162 (24%), Positives = 67/162 (41%), Gaps = 11/162 (6%)
Query: 273 LVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQ--------CSHEAL 324
+++ ++ G R+G L GD +L V+G+ + H A+ LRQ E
Sbjct: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
Query: 325 FQVEYDVATPDTVANASGPLMVEIVK-TPGSALGISLTTTSLRNKSVITIDRIKPASVVD 383
F+ + PD V + K +P LGI L ++ + I + V
Sbjct: 361 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV--DEPGVFIFNVLDGGVAY 418
Query: 384 RSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425
R G L D +L+I+G + + S A L+ + +V L +
Sbjct: 419 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV 460
Score = 30.8 bits (68), Expect = 7.7
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 10/106 (9%)
Query: 1040 VTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHR-GGLQPFDRVLQVNHVRTRDFD 1098
V L+K G + + E GV++ V G A+R G L+ DRVL +N R
Sbjct: 382 VILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGS 441
Query: 1099 CCLAVPLLAEAGDVLELIISRK---------PHTAHSSRAPRSPGP 1135
A L+ + + L++SR+ +S SPGP
Sbjct: 442 PESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGP 487
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 77.4 bits (189), Expect = 7e-14
Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 33/206 (16%)
Query: 145 VVELIKKEGSTLGLTISGGTDK---DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHL 201
VV + K G +LG+T++GG D V ++ PGG+ +R + GD + +V+G+ L
Sbjct: 411 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVEL 470
Query: 202 TRLRHDEIITLLKNVGERVVLEV----EYE-----LPPPAPENN---------------- 236
T + E + LLK +VL+ EYE P A ++N
Sbjct: 471 TEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 530
Query: 237 ---PRIISKTVDVSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKV 292
PR + D+ L + S GF + GG +E+ + ++P + + G PA +G ++
Sbjct: 531 LELPRCLYNCKDIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRC 589
Query: 293 GDRLLSVDGIPLHGASHATALATLRQ 318
GD LL+V+G G HA L++
Sbjct: 590 GDILLAVNGRSTSGMIHACLARLLKE 615
Score = 70.1 bits (170), Expect = 1e-11
Identities = 90/331 (27%), Positives = 136/331 (41%), Gaps = 52/331 (15%)
Query: 543 PGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQV 602
P G+I + V DP ++L GG +ET ++ I D R G L
Sbjct: 172 PDGEITSIKINRV----DPSESLSIRLVGG---SETPLVHIIIQHIYRDGVIARDGRLLP 224
Query: 603 GDRVLSINGIATEDGTMEEANQLLRD--AALAHKVVLEVEF------DVAESVIPSSGTF 654
GD +L +NG+ + A +LLR L V+ E +F ++ P +F
Sbjct: 225 GDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSF 284
Query: 655 HVKLPKKRSVE-LGITISSASRKRGEP-LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRL 712
HV L K E LGI + RK EP + I ++ G VA+R G LE D++LAI+ L
Sbjct: 285 HVILNKSSPEEQLGIKL---VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDL 341
Query: 713 DNCPMEDAVQILRQCEDLVKLKIRKD--------------EDNSDELETTGAVSYTVE-- 756
E A +++ E V L + + N G S T +
Sbjct: 342 RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 401
Query: 757 -------------LKRYGGPLGITISG--TEEPFD-PIVISGLTKRGLAERTGAIHVGDR 800
K G LG+T++G + +D PI + + G+ R G I GD
Sbjct: 402 HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDI 461
Query: 801 ILAINNVSLKGRPLSEAIHLLQVAGETVTLK 831
+L ++ V L SEA+ LL+ ++ LK
Sbjct: 462 LLNVDGVELTEVSRSEAVALLKRTSSSIVLK 492
Score = 65.5 bits (158), Expect = 3e-10
Identities = 79/330 (23%), Positives = 127/330 (38%), Gaps = 49/330 (14%)
Query: 172 VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPP 231
+ ++ G+ AR L GD I VNG+ ++ + H+ + LL+ + + L V E
Sbjct: 207 IQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFR 266
Query: 232 APENN-------PRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPA 284
+ N PR S V ++ G L E G + + V GG A
Sbjct: 267 SRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPG-----VFIFNVLDGGVA 321
Query: 285 DREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVAT----------- 333
R G L+ DR+L+++G L S +A ++ V V
Sbjct: 322 YRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGW 381
Query: 334 ---------PDTVANASGPL---------MVEIVKTPGSALGISLTTTSLRNK--SVITI 373
P +N PL +V I K PG +LG+++ + + I +
Sbjct: 382 NSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYV 441
Query: 374 DRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQR 433
++P V+ R G + GD +L++DG + S EA LL S + L+ L V + +
Sbjct: 442 ISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE- 500
Query: 434 PLRPQRQVVKVQRSEQLHRWDPCVPSCHSP 463
PQ + H P PS SP
Sbjct: 501 ---PQEDCSSPAALDSNHNMAP--PSDWSP 525
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/216 (26%), Positives = 92/216 (42%), Gaps = 48/216 (22%)
Query: 134 QSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYI 193
+S PEE GI +V + + G + N+ GG+A R L D +
Sbjct: 290 KSSPEEQLGIKLVRKVDEPGVF----------------IFNVLDGGVAYRHGQLEENDRV 333
Query: 194 RSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPE------------------- 234
++NG L + L++ RV L V ++ +P+
Sbjct: 334 LAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGE 393
Query: 235 --NNPRIISKTVD-----VSLYKE-GNSFGFVLRGGAHEDGHKS--RPLVLTYVRPGGPA 284
N P+ + T+ V++ K+ G S G + GGA H+ P+ + V PGG
Sbjct: 394 RSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGA---SHREWDLPIYVISVEPGGVI 450
Query: 285 DREGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
R+G +K GD LL+VDG+ L S + A+A L++ S
Sbjct: 451 SRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTS 486
Score = 55.5 bits (132), Expect = 3e-07
Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 9/199 (4%)
Query: 647 VIPSSGTFHVKLPK-KRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLL 705
+IP +K+ + S L I + S +II I + V R G L PGD +L
Sbjct: 170 LIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIIL 229
Query: 706 AIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDE-------DNSDELETTGAVSYTVELK 758
++ + + N P AV++LRQ ++ L + +++ + + S+ V L
Sbjct: 230 KVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILN 289
Query: 759 RYGGPLGITISGTEEPFDP-IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEA 817
+ + I + +P + I + G+A R G + DR+LAIN L+ A
Sbjct: 290 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA 349
Query: 818 IHLLQVAGETVTLKIKKQL 836
HL+Q + V L + +Q+
Sbjct: 350 AHLIQASERRVHLVVSRQV 368
Score = 44.3 bits (103), Expect = 7e-04
Identities = 39/162 (24%), Positives = 67/162 (41%), Gaps = 11/162 (6%)
Query: 273 LVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQ--------CSHEAL 324
+++ ++ G R+G L GD +L V+G+ + H A+ LRQ E
Sbjct: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264
Query: 325 FQVEYDVATPDTVANASGPLMVEIVK-TPGSALGISLTTTSLRNKSVITIDRIKPASVVD 383
F+ + PD V + K +P LGI L ++ + I + V
Sbjct: 265 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV--DEPGVFIFNVLDGGVAY 322
Query: 384 RSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425
R G L D +L+I+G + + S A L+ + +V L +
Sbjct: 323 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV 364
Score = 30.8 bits (68), Expect = 7.7
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 10/106 (9%)
Query: 1040 VTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHR-GGLQPFDRVLQVNHVRTRDFD 1098
V L+K G + + E GV++ V G A+R G L+ DRVL +N R
Sbjct: 286 VILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGS 345
Query: 1099 CCLAVPLLAEAGDVLELIISRK---------PHTAHSSRAPRSPGP 1135
A L+ + + L++SR+ +S SPGP
Sbjct: 346 PESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGP 391
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 72.8 bits (177), Expect = 2e-12
Identities = 107/469 (22%), Positives = 171/469 (36%), Gaps = 89/469 (18%)
Query: 242 KTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDG 301
K +DV L + + FGF + GG +P+++ V G ADR+G L GD L+ VDG
Sbjct: 775 KELDVHLRRMESGFGFRILGG----DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDG 830
Query: 302 IPLHGASHATAL-------------ATLRQ-------------------CSHEALFQVEY 329
IP+ G +H + T+R+ +H + + +Y
Sbjct: 831 IPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDY 890
Query: 330 DVATPDTVA----NASGP------------LMVEIVKTPGSALGISLTTTSLRNKSVIT- 372
T A NAS P +++ + G I + + S IT
Sbjct: 891 ATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITV 950
Query: 373 ---IDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVP 429
I RI S DR L GD IL+++G S+ + + KL+ V L I+P
Sbjct: 951 PHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQE 1010
Query: 430 QSQRPL--------RPQRQVVKVQRSEQLHRWDPCVPSCHSPRP---------GHCRMPT 472
+ P P Q + + L + P P+ +P GH
Sbjct: 1011 ELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYR 1070
Query: 473 WATPAGQDQSRSLSSTPFS---SPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRRE 529
A QD + PF+ P L++ P G P R+
Sbjct: 1071 SEVKARQDVKPDIRQPPFTDYRQPPLDY--------RQPPGGDYQQPPPLDYRQPPLLDY 1122
Query: 530 HKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIE 589
+ S + Q + V + GFG ++GG V +
Sbjct: 1123 RQHSPDTRQYPLSDYRQPQDFDYFTVDM-EKGAKGFGFSIRGG----REYKMDLYVLRLA 1177
Query: 590 PDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLE 638
D PA R G ++VGD+++ ING +T D T A +L++ +++L+
Sbjct: 1178 EDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLK 1226
Score = 50.8 bits (120), Expect = 7e-06
Identities = 97/408 (23%), Positives = 148/408 (36%), Gaps = 71/408 (17%)
Query: 563 SGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622
SGFG ++ GG + P L+ + A+R G L GD ++ ++GI
Sbjct: 786 SGFGFRILGG----DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPV-------- 833
Query: 623 NQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLI 682
A H+ V+++ A + V L +R V G GEP
Sbjct: 834 ------AGKTHRYVIDLMHHAARNG-------QVNLTVRRKVLCG----------GEPCP 870
Query: 683 ISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNS 742
+ GSV+ T P N P +A + S
Sbjct: 871 ENGRSPGSVS--THHSSPRSDYATYTNSN-HAAPSSNASP--------------PEGFAS 913
Query: 743 DELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGL------AERTGAIH 796
L+T+ V + E + +G + IS P I+ K G A+R +
Sbjct: 914 HSLQTSDVVIHRKENEGFGF---VIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLK 970
Query: 797 VGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADE 856
VGDRILA+N S+ P ++ + L++ AG +VTL+I Q + S ++ A +
Sbjct: 971 VGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQ 1030
Query: 857 DPADALKGGLPAARFSPAVPSVDSAVESWDSSATEGGFGGPGSYTPQAAAR-GTTPQERR 915
P L P A+ SPA P+ A + G SY + AR P R+
Sbjct: 1031 SP---LAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGH--ENSYRSEVKARQDVKPDIRQ 1085
Query: 916 PGWLRGSPPPTEPRRTS----YTPTPADESFPEEEEEDDWEPPTSPAP 959
P + PP + R+ P P D P + P T P
Sbjct: 1086 PPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYP 1133
Score = 47.0 bits (110), Expect = 1e-04
Identities = 52/244 (21%), Positives = 93/244 (38%), Gaps = 22/244 (9%)
Query: 597 CGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHV 656
C L GD ++ IN ++ + E +L+D + + L +I G F
Sbjct: 637 CPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL---------IIHRGGFFSP 687
Query: 657 KLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCP 716
K ++ S P I ++ HR+ D A D + D
Sbjct: 688 WKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSF---PDSTEAFDPRKPDPYE 744
Query: 717 MEDAVQILRQCEDLV--KLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEP 774
+ + + + + V + R D D E V L+R G I G +EP
Sbjct: 745 LYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELD------VHLRRMESGFGFRILGGDEP 798
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGET--VTLKI 832
PI+I + G A+R G +H GD ++ ++ + + G+ I L+ A V L +
Sbjct: 799 GQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTV 858
Query: 833 KKQL 836
++++
Sbjct: 859 RRKV 862
Score = 44.3 bits (103), Expect = 7e-04
Identities = 37/131 (28%), Positives = 62/131 (47%), Gaps = 5/131 (3%)
Query: 753 YTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGR 812
+TV++++ G +I G E + + L + G A R G + VGD+I+ IN S +
Sbjct: 1146 FTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDM 1205
Query: 813 PLSEAIHLLQVAGETVTLKIKK---QLDRPLLPRKSGSLSETSDADEDPADALKGGLPAA 869
+ AI L++ G V L +K+ Q+ P S + + + +L GL A
Sbjct: 1206 THARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGL--A 1263
Query: 870 RFSPAVPSVDS 880
FSP+ P+ S
Sbjct: 1264 PFSPSHPAPPS 1274
Score = 42.4 bits (98), Expect = 0.003
Identities = 28/111 (25%), Positives = 48/111 (43%), Gaps = 12/111 (10%)
Query: 246 VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLH 305
V + K FGF +RGG L + + GPA R G ++VGD+++ ++G
Sbjct: 1148 VDMEKGAKGFGFSIRGGREY----KMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203
Query: 306 GASHATALATLRQCSHEALFQV--------EYDVATPDTVANASGPLMVEI 348
+HA A+ ++ + EYD P + A+ P + E+
Sbjct: 1204 DMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEV 1254
Score = 41.2 bits (95), Expect = 0.006
Identities = 31/104 (29%), Positives = 51/104 (49%), Gaps = 6/104 (5%)
Query: 139 EFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNG 198
+ +G + +KK G TI GG + D +V ++ P G AA+ + GD I +N
Sbjct: 419 QLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE 478
Query: 199 IHLTRLRHDEIITLLKNV--GERV--VLEVEYELP--PPAPENN 236
+ + H +++ L ++V G+ V VL Y LP P P N+
Sbjct: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANS 522
Score = 41.2 bits (95), Expect = 0.006
Identities = 32/107 (29%), Positives = 49/107 (45%), Gaps = 8/107 (7%)
Query: 137 PEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSV 196
P++F TV ++K G +I GG + V L G A R+ + +GD I +
Sbjct: 1140 PQDFDYFTVD--MEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEI 1197
Query: 197 NGIHLTRLRHDEIITLLKNVGERVVLEVEY------ELPPPAPENNP 237
NG + H I L+K+ G RV L ++ E PAP ++P
Sbjct: 1198 NGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSP 1244
Score = 40.8 bits (94), Expect = 0.007
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 2/88 (2%)
Query: 1034 PLEMHKVTLHKDPMRHDFGFSVSDGLLEK-GVYVHTVRPDGPAHRGG-LQPFDRVLQVNH 1091
P + T+ + FGFS+ G K +YV + DGPA R G ++ D+++++N
Sbjct: 1140 PQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEING 1199
Query: 1092 VRTRDFDCCLAVPLLAEAGDVLELIISR 1119
TRD A+ L+ G + L++ R
Sbjct: 1200 ESTRDMTHARAIELIKSGGRRVRLLLKR 1227
Score = 39.7 bits (91), Expect = 0.017
Identities = 41/158 (25%), Positives = 66/158 (41%), Gaps = 14/158 (8%)
Query: 757 LKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSE 816
LK+ G TI G +EP + + + + G A + G + GD I+ IN V + G ++
Sbjct: 429 LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 488
Query: 817 AIHLLQVA--GETVTLKIKKQLDRPLLPR-KSGSLSETSDADEDPADALKGGLP------ 867
+ L Q G++V L + + P P + S+ E P + G
Sbjct: 489 VVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYL 548
Query: 868 --AARFSPAVPSV-DSAVESWDSSATEGGFGGPGSYTP 902
+R S +VP + D S S T+G G+Y P
Sbjct: 549 EYISRTSQSVPDITDRPPHSLHSMPTDGQL--DGTYPP 584
Score = 37.4 bits (85), Expect = 0.082
Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 15/103 (14%)
Query: 138 EEFRGITVVELIKKE-GSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSV 196
E F + + L + E GST+ + G DG P A R L +GD I +V
Sbjct: 929 EGFGFVIISSLNRPESGSTITVPHKIGRIIDGSP----------ADRCAKLKVGDRILAV 978
Query: 197 NGIHLTRLRHDEIITLLKNVGERVVLEV----EYELPPPAPEN 235
NG + + H +I+ L+K+ G V L + E P AP +
Sbjct: 979 NGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSS 1021
Score = 36.2 bits (82), Expect = 0.18
Identities = 20/67 (29%), Positives = 35/67 (52%), Gaps = 4/67 (5%)
Query: 244 VDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIP 303
+ +L K FGF + GG D L + V P GPA ++G ++ GD ++ ++ +
Sbjct: 425 LSTTLKKSNMGFGFTIIGGDEPDEF----LQVKSVIPDGPAAQDGKMETGDVIVYINEVC 480
Query: 304 LHGASHA 310
+ G +HA
Sbjct: 481 VLGHTHA 487
Score = 31.6 bits (70), Expect = 4.5
Identities = 17/74 (22%), Positives = 40/74 (54%), Gaps = 2/74 (2%)
Query: 665 ELGITISSASRKRGEPLIISDIKKGSVAHRTGT-LEPGDKLLAIDNIRLDNCPMEDAVQI 723
+LG + + + G+ + ++K G VA+ +G+ L + LL ++ + + D + +
Sbjct: 27 QLGFELKGGA-ENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAV 85
Query: 724 LRQCEDLVKLKIRK 737
++ C+D ++LK K
Sbjct: 86 IKHCKDPLRLKCVK 99
Score = 31.6 bits (70), Expect = 4.5
Identities = 20/74 (27%), Positives = 33/74 (44%), Gaps = 4/74 (5%)
Query: 564 GFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEAN 623
GFG + GG E L ++ PD PA + G ++ GD ++ IN + T +
Sbjct: 435 GFGFTIIGGDEPDEFLQVKSVI----PDGPAAQDGKMETGDVIVYINEVCVLGHTHADVV 490
Query: 624 QLLRDAALAHKVVL 637
+L + + V L
Sbjct: 491 KLFQSVPIGQSVNL 504
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 72.8 bits (177), Expect = 2e-12
Identities = 124/606 (20%), Positives = 215/606 (35%), Gaps = 113/606 (18%)
Query: 245 DVSLYKEGNSFGFVL-----RGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSV 299
+V L K NS G + +GG + V + P G A+ +G + GDR+L+V
Sbjct: 1368 EVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVI-PQGAAESDGRIHKGDRVLAV 1426
Query: 300 DGIPLHGASHATALATLRQCSH---------EALFQVEYDVATPDTVA---NASGPLMVE 347
+G+ L GA+H A+ TLR ++ E+ TP NA G +
Sbjct: 1427 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1486
Query: 348 IVKTP---------------------GSALGISLTTTSLR-----NKSVITIDRIKPASV 381
+ KT S LG S + N S++ + ++ P
Sbjct: 1487 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1546
Query: 382 VDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRL-------EILP------- 427
SG + GD IL ++G S++ S E L + +V L +LP
Sbjct: 1547 AAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALL 1606
Query: 428 ---------VPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPR-------------- 464
+P S + V + S++ D C SP
Sbjct: 1607 TPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGED 1666
Query: 465 -----PGHCRMPTWATPAGQDQSRSLSSTP--FSSPTLNHAFSC----------NNPSTL 507
P + TW++ Q S +S +P C N P
Sbjct: 1667 DLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFE 1726
Query: 508 PRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVL--CGDPLSGF 565
P+ P G+ Q + E SS S+ + + E + + L F
Sbjct: 1727 DSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDF 1786
Query: 566 GLQLQ----------GGIFATETLSSPPLVCFIEP--DSPAERCGLLQVGDRVLSINGIA 613
L+++ G + T T + + C++ PA+ G L+ GDR++ +N
Sbjct: 1787 ELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTD 1846
Query: 614 TEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSA 673
+ T +A LLR A+ ++V+ ++ + + L + ELG ++
Sbjct: 1847 VTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKE-ELGFSLCGG 1905
Query: 674 SRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKL 733
+ + ISDI SVA G L+ D + ++ + +E+ + L + L
Sbjct: 1906 HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVL 1965
Query: 734 KIRKDE 739
K +++
Sbjct: 1966 KATRND 1971
Score = 60.5 bits (145), Expect = 9e-09
Identities = 130/560 (23%), Positives = 195/560 (34%), Gaps = 115/560 (20%)
Query: 638 EVEFDVAESVIPSSGT-FHVKLPKKRSVELGITIS--------SASRKRGEPLIISDIKK 688
++ F S P G F V+L K + LGI+++ + S + G + + I +
Sbjct: 1350 KMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQ 1408
Query: 689 GSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDE---- 744
G+ A G + GD++LA++ + L+ + AV+ LR +V L + K + + +
Sbjct: 1409 GA-AESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 1467
Query: 745 --------------------LETTGAVSY-------TVELKRYGGPLGITISGTEEP--- 774
+TT Y T E+K + G+ S + E
Sbjct: 1468 VTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLI 1527
Query: 775 -----FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVT 829
+ + L A +G I VGD IL +N SLKG E I L+ V
Sbjct: 1528 PEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVF 1587
Query: 830 LKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPS-VDSAVES---- 884
L L RP G L E A P + LP + + PS V+ + S
Sbjct: 1588 LL----LCRP----PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENE 1639
Query: 885 --------------WDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGS-------- 922
DS + G G T A +T L
Sbjct: 1640 MSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHH 1699
Query: 923 PPPTEPRRTSYTPTPADESFPEEEEEDDWEP---PTSPAPGPAREEGFWRMFGEALEDLE 979
P T T + P + E +D P P APG + + E
Sbjct: 1700 EAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQP-----------QSE 1748
Query: 980 SCGQSELLRELEASIMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHK 1039
S S + + I T Q P + E E+E LL T ++ K
Sbjct: 1749 SASSSSMDKYHIHHISEPTRQE-------NWTPLKNDLENHLEDFELEVELLITLIKSEK 1801
Query: 1040 VTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGGLQPFDRVLQVNHVRTRDFDC 1099
+L GF+V+ G G YVH V D G L+P DR+++VN +
Sbjct: 1802 GSL---------GFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1852
Query: 1100 CLAVPLLAEAGDVLELIISR 1119
AV LL A + L+I R
Sbjct: 1853 TDAVNLLRAASKTVRLVIGR 1872
Score = 60.1 bits (144), Expect = 1e-08
Identities = 64/234 (27%), Positives = 99/234 (42%), Gaps = 52/234 (22%)
Query: 135 SIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGL---------AARSD 185
S P + I VEL K + S LG++++ DK G +++R GG+ AA SD
Sbjct: 1358 SSPPKPGDIFEVELAKNDNS-LGISVTVLFDKGGVN--TSVRHGGIYVKAVIPQGAAESD 1414
Query: 186 -LLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPEN--------- 235
++ GD + +VNG+ L H + + L+N G+ V L +E P + E+
Sbjct: 1415 GRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTL 1474
Query: 236 --------NPRIISKTV--------------DVSLYKEGNSFGFVLRGGAHEDGHKSRPL 273
P + KT +V L+K + GF + ED +
Sbjct: 1475 SDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSF---SREDNLIPEQI 1531
Query: 274 VLTYVR-----PGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHE 322
+ VR PG PA G + VGD +L V+G L G S ++ LR + E
Sbjct: 1532 NASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE 1585
Score = 53.1 bits (126), Expect = 1e-06
Identities = 30/78 (38%), Positives = 44/78 (56%), Gaps = 2/78 (2%)
Query: 246 VSLYKEGN-SFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPL 304
V+L K+ GF + GG + G + ++ V PGGPAD +G LK GDRL+SV+ + L
Sbjct: 1094 VNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152
Query: 305 HGASHATALATLRQCSHE 322
G SH A+ L+ +
Sbjct: 1153 EGVSHHAAIEILQNAPED 1170
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/193 (24%), Positives = 88/193 (45%), Gaps = 6/193 (3%)
Query: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715
+ L K LG T++ +++ G + D+ + A G L+PGD+L+ +++ + N
Sbjct: 1794 ITLIKSEKGSLGFTVTKGNQRIG--CYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1850
Query: 716 PMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEP- 774
DAV +LR V+L I + + + + + L LG ++ G +
Sbjct: 1851 THTDAVNLLRAASKTVRLVIGRVLE-LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSL 1909
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ + IS + R +A G + + D I +N VS +G L E L ++ ++ LK +
Sbjct: 1910 YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATR 1969
Query: 835 QLDRPLLPRKSGS 847
D P++P S
Sbjct: 1970 N-DLPVVPSSKRS 1981
Score = 49.7 bits (117), Expect = 2e-05
Identities = 84/390 (21%), Positives = 138/390 (35%), Gaps = 74/390 (18%)
Query: 778 IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLD 837
I IS + G A+ G + GDR++++N+VSL+G AI +LQ A E VTL I + +
Sbjct: 1121 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Query: 838 RPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVES------WDSSA-- 889
+ +S+ + +K + + + DSA++S W
Sbjct: 1181 K---------ISKVPSTPVHLTNEMKNYMKKSSYMQ-----DSAIDSSSKDHHWSRGTLR 1226
Query: 890 --TEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEEE 947
+E FG G R G L TE S + + + F
Sbjct: 1227 HISENSFGPSGGL--------------REGSLSSQDSRTE--SASLSQSQVNGFFASHLG 1270
Query: 948 EDDWEPPTSPAPGP-----AREEGFWRMFGEA---------LEDLESCGQSELLRELEAS 993
+ W+ +P P A E+ + ++ + D G S++ +S
Sbjct: 1271 DQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSS 1330
Query: 994 IMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGF 1053
+ + +SP P P ++ +V L K+ + G
Sbjct: 1331 SQDHQTPKQESSSSVNTSNKMNFKTFSSSP--------PKPGDIFEVELAKND--NSLGI 1380
Query: 1054 S---------VSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAV 1103
S V+ + G+YV V P G A G + DRVL VN V AV
Sbjct: 1381 SVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAV 1440
Query: 1104 PLLAEAGDVLELIISRKPHTAHSSRAPRSP 1133
L G V+ L++ + P +P
Sbjct: 1441 ETLRNTGQVVHLLLEKGQSPTSKEHVPVTP 1470
Score = 45.8 bits (107), Expect = 2e-04
Identities = 43/163 (26%), Positives = 77/163 (47%), Gaps = 10/163 (6%)
Query: 145 VVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSD-LLNIGDYIRSVNGIHLTR 203
++ LIK E +LG T++ G + G ++ A+SD L GD + VN +T
Sbjct: 1793 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQD---PAKSDGRLKPGDRLIKVNDTDVTN 1849
Query: 204 LRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGA 263
+ H + + LL+ + V L + L P P ++ D++L GF L GG
Sbjct: 1850 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLP---DITLTCNKEELGFSLCGG- 1905
Query: 264 HEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHG 306
H+ + + + ++ + P A EG+L++ D + V+G+ G
Sbjct: 1906 HDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQG 1946
Score = 45.4 bits (106), Expect = 3e-04
Identities = 36/145 (24%), Positives = 63/145 (43%), Gaps = 5/145 (3%)
Query: 618 TMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASR-- 675
TM + L VL + + S P V L K LG I +
Sbjct: 1058 TMHSSGNSSSQVPLKENDVLHKRWSIVSS--PEREITLVNLKKDAKYGLGFQIIGGEKMG 1115
Query: 676 KRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKI 735
+ + IS + G A G L+PGD+L++++++ L+ A++IL+ + V L I
Sbjct: 1116 RLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
Query: 736 RKDEDNSDELETTGAVSYTVELKRY 760
+ ++ ++ +T V T E+K Y
Sbjct: 1176 SQPKEKISKVPST-PVHLTNEMKNY 1199
Score = 43.9 bits (102), Expect = 9e-04
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 8/103 (7%)
Query: 1036 EMHKVTLHKDPMRHDFGFSVSDG----LLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVN 1090
E+ V L KD ++ GF + G L+ G+++ +V P GPA G L+P DR++ VN
Sbjct: 1090 EITLVNLKKDA-KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1148
Query: 1091 HVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSP 1133
V A+ +L A + + L+IS+ S+ P +P
Sbjct: 1149 SVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKI--SKVPSTP 1189
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 7/94 (7%)
Query: 135 SIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPR----VSNLRPGGLAARSDLLNIG 190
S PE R IT+V L K LG I GG +K G+ +S++ PGG A L G
Sbjct: 1085 SSPE--REITLVNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141
Query: 191 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV 224
D + SVN + L + H I +L+N E V L +
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
Score = 39.7 bits (91), Expect = 0.017
Identities = 24/71 (33%), Positives = 35/71 (49%)
Query: 171 RVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPP 230
RV L PG AA S +++GD I VNG L L E+I+ L+ V L + P
Sbjct: 1537 RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG 1596
Query: 231 PAPENNPRIIS 241
PE + +++
Sbjct: 1597 VLPEIDTALLT 1607
Score = 38.9 bits (89), Expect = 0.028
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 551 ETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIE---PDSPAERCGLLQVGDRVL 607
E T V L D G G Q+ GG E + L FI P PA+ G L+ GDR++
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIGG----EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 1145
Query: 608 SINGIATEDGTMEEANQLLRDA 629
S+N ++ E + A ++L++A
Sbjct: 1146 SVNSVSLEGVSHHAAIEILQNA 1167
Score = 38.5 bits (88), Expect = 0.037
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 6/110 (5%)
Query: 566 GLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
G L GG ++L + I P S A G LQ+ D + +NG++T+ T+EE N+
Sbjct: 1899 GFSLCGG---HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1955
Query: 626 LRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASR 675
L D +L V+ D+ V+PSS V PK ++ S S+
Sbjct: 1956 L-DMSLPSLVLKATRNDL--PVVPSSKRSAVSAPKSTKGNGSYSVGSCSQ 2002
Score = 36.2 bits (82), Expect = 0.18
Identities = 19/55 (34%), Positives = 28/55 (50%)
Query: 371 ITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425
I I + P D G L PGD ++S++ S+E S A ++L + E V L I
Sbjct: 1121 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 72.8 bits (177), Expect = 2e-12
Identities = 59/206 (28%), Positives = 91/206 (44%), Gaps = 35/206 (16%)
Query: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKP-RVSNLRPGGLAARSDLLNIGDYIRSV 196
E + + L +KEGS LG +++GGTD + K V + G A++ +N GD++ SV
Sbjct: 2615 ENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSV 2674
Query: 197 NGIHLTRLRHDEIITLLKNV----GERVVLEVEYELPPPAPENNPRIIS-------KTVD 245
NG L L H ++ +L VV++ + P P+ P + KT+
Sbjct: 2675 NGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIP 2734
Query: 246 ----------------VSLYKEGNSFGFVLRGGAHE---DGHKSRPLVLTYVRPGGPADR 286
V + K G L GG DG PLV+ V GG A++
Sbjct: 2735 LEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDG----PLVIKRVYKGGAAEQ 2790
Query: 287 EGSLKVGDRLLSVDGIPLHGASHATA 312
G ++ GD +L+++G PL G H A
Sbjct: 2791 AGIIEAGDEILAINGKPLVGLMHFDA 2816
Score = 60.8 bits (146), Expect = 7e-09
Identities = 52/202 (25%), Positives = 86/202 (42%), Gaps = 36/202 (17%)
Query: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309
KEG+ GF + GG + + + + V G A +EG++ GD LLSV+G L G +H
Sbjct: 2628 KEGSGLGFSVAGGTDVE---PKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684
Query: 310 ATALATLRQCS--HEALFQVEYDVATPDTVANASGP------------------------ 343
L L Q +AL ++ + P A P
Sbjct: 2685 GNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVA 2744
Query: 344 ----LMVEIVKTPGSALGISLT--TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSI 397
L VE++KT + LG+SL +S+ + I R+ +++G + GD IL+I
Sbjct: 2745 VHDALCVEVLKT-SAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAI 2803
Query: 398 DGTSMEHCSLLEATKLLASISE 419
+G + +A ++ S+ E
Sbjct: 2804 NGKPLVGLMHFDAWNIMKSVPE 2825
Score = 55.8 bits (133), Expect = 2e-07
Identities = 130/573 (22%), Positives = 202/573 (35%), Gaps = 137/573 (23%)
Query: 111 DDGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKP 170
D +SKGGK + LA EE I +EL+K E LG+ +SGG P
Sbjct: 306 DKRRFSKGGKTDFQSSDCLA------REEVGRIWKMELLK-ESDGLGIQVSGGRGSKRSP 358
Query: 171 R---VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEV--- 224
V+ ++ GG A R L++GD + +NG L L H+E + +L++ V L V
Sbjct: 359 HAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASK 418
Query: 225 ---EYELPPPAPENNPRIISKTVDVSLY------------KEGNSFGFV----------- 258
+L ++ P + S DVS + EG S
Sbjct: 419 ENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQD 478
Query: 259 LRGGAHEDGHKSRP-----LVLTYVRPGGPADREGSLKVGDRLLSVDGIP---LHGASHA 310
+ G G+ P + R G R S++ + L+ +G P + S
Sbjct: 479 VCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRD 538
Query: 311 TALATLRQCSHEALFQVEYDVATPDTVANAS----------GPLMVEIV---KTPGSALG 357
+L Q + EY + T + ++ P ++ I+ K G LG
Sbjct: 539 GRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLG 598
Query: 358 ISLT--TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLA 415
S+ +R + I + I P G L GD IL ++G ++ + EA
Sbjct: 599 FSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 658
Query: 416 SISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWAT 475
I + L +L V + ++V SP C PT
Sbjct: 659 QI--RSGLFVLTV---------RTKLV-------------------SPSLTPCSTPT--- 685
Query: 476 PAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLS 535
SRS +SP N T G + SS S
Sbjct: 686 ----HMSRS------ASPNFN----------------------TSGGASAGGSDEGSSSS 713
Query: 536 LASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPP--LVCFIEPDSP 593
L T GP +IV EV L +P G G+ G +SPP + + P S
Sbjct: 714 LGRKTPGPKDRIV----MEVTLNKEPRVGLGI----GACCLALENSPPGIYIHSLAPGSV 765
Query: 594 AERCGLLQVGDRVLSINGIATEDGTMEEANQLL 626
A+ L GD++L +N + + + + +L
Sbjct: 766 AKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 798
Score = 54.7 bits (130), Expect = 5e-07
Identities = 30/87 (34%), Positives = 49/87 (56%), Gaps = 2/87 (2%)
Query: 661 KRSVELGITISSASRKRGEP--LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPME 718
K S LGI +S + P ++++ +K+G AHR G L GD+LL I+ L E
Sbjct: 339 KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398
Query: 719 DAVQILRQCEDLVKLKIRKDEDNSDEL 745
+AV ILR +V+L + E+++++L
Sbjct: 399 EAVAILRSATGMVQLVVASKENSAEDL 425
Score = 53.9 bits (128), Expect = 8e-07
Identities = 54/215 (25%), Positives = 83/215 (38%), Gaps = 47/215 (21%)
Query: 246 VSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPL 304
+ LYKE G GF + GG + V T + P G A +G LK GD +L V+GIP+
Sbjct: 587 IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKT-IFPNGSAAEDGRLKEGDEILDVNGIPI 645
Query: 305 HGASHATALATLRQCSHEALFQVEYDV----------ATPDTVANASGP----------- 343
G + A+ T +Q LF + +TP ++ ++ P
Sbjct: 646 KGLTFQEAIHTFKQI-RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAG 704
Query: 344 ----------------------LMVEIVKTPGSALGISLTTTSLRNKSV-ITIDRIKPAS 380
+ V + K P LGI +L N I I + P S
Sbjct: 705 GSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGS 764
Query: 381 VVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLA 415
V L GD IL ++ ++ H +L + +L+
Sbjct: 765 VAKMESNLSRGDQILEVNSVNVRHAALSKVHAILS 799
Score = 52.4 bits (124), Expect = 2e-06
Identities = 115/556 (20%), Positives = 199/556 (35%), Gaps = 96/556 (17%)
Query: 323 ALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVV 382
+ F V+ + + + +ANA P V G++ +S+++ I R S+V
Sbjct: 2331 SFFSVKQRIKSFENLANADRP-----VAKSGASPFLSVSSKP-------PIGRRSSGSIV 2378
Query: 383 DRSGAL-HPGDHILSIDGTSMEHCS--LLEATKLLASISEKVRLEILPVPQSQRPLRPQR 439
SG+L HPGD + S+ CS EA LL +++ + L + + P
Sbjct: 2379 --SGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPP----- 2431
Query: 440 QVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAF 499
T + + + +SL +PT+ A
Sbjct: 2432 -------------------------------ETSSKGSDSELKKSLGPLGIPTPTMTLAS 2460
Query: 500 SCNNPSTLPRGSQPMSP--RTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTET--TEV 555
+ R +QP SP R+ + R L + GP + TE T
Sbjct: 2461 PVKRNKSSVRHTQP-SPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPR 2519
Query: 556 VLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQ--VGDRVLSIN--G 611
G P G +GG A S P P S ++ Q R S+N
Sbjct: 2520 RSPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQ 2579
Query: 612 IATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITIS 671
+ G + +L ++ ++ A+S F V L +K LG +++
Sbjct: 2580 LLVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIV-LNRKEGSGLGFSVA 2638
Query: 672 SASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCE--- 728
+ + + + + A + GT+ GD LL+++ L + +++L Q +
Sbjct: 2639 GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHK 2698
Query: 729 -DLVKLKIRKDEDNSDELETTGAVS-------------------------YTVELKRYGG 762
LV +K D+ + + VE+ +
Sbjct: 2699 DALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSA 2758
Query: 763 PLGITISGTEEPFD---PIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIH 819
LG+++ G + P+VI + K G AE+ G I GD ILAIN L G +A +
Sbjct: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
Query: 820 LLQVAGE-TVTLKIKK 834
+++ E V L I+K
Sbjct: 2819 IMKSVPEGPVQLLIRK 2834
Score = 45.1 bits (105), Expect = 4e-04
Identities = 45/179 (25%), Positives = 79/179 (44%), Gaps = 18/179 (10%)
Query: 736 RKDEDNSDEL--ETTGAVSYTVELKRYGGPLGITISG---TEEPFDPIVISGLTKRGLAE 790
+ D +SD L E G + + +EL + LGI +SG ++ IV++ + + G A
Sbjct: 315 KTDFQSSDCLAREEVGRI-WKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAH 373
Query: 791 RTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK---------QLDRPLL 841
R G + +GD +L IN L G EA+ +L+ A V L + +L L
Sbjct: 374 RDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSL 433
Query: 842 PRKSGSLSETS---DADEDPADALKGGLPAARFSPAVPSVDSAVESWDSSATEGGFGGP 897
P + S+ + S D ++ AD + ++ A+P D + + ++G P
Sbjct: 434 PDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESP 492
Score = 41.2 bits (95), Expect = 0.006
Identities = 58/213 (27%), Positives = 88/213 (41%), Gaps = 37/213 (17%)
Query: 563 SGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622
SG G + GG T+ V + A + G + GD +LS+NG +
Sbjct: 2631 SGLGFSVAGG---TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
Query: 623 NQLLRDAALAHK---VVLEVEFD------------------VAESVIP------SSGTFH 655
++L A L HK VV++ D ++ IP S H
Sbjct: 2688 LKVLHQAQL-HKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVH 2746
Query: 656 VKL---PKKRSVELGITISSA-SRKRGE-PLIISDIKKGSVAHRTGTLEPGDKLLAIDNI 710
L K S LG+++ S G+ PL+I + KG A + G +E GD++LAI+
Sbjct: 2747 DALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGK 2806
Query: 711 RLDNCPMEDAVQILRQC-EDLVKLKIRKDEDNS 742
L DA I++ E V+L IRK ++S
Sbjct: 2807 PLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS 2839
Score = 39.3 bits (90), Expect = 0.022
Identities = 22/73 (30%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 149 IKKEGSTLGLTISGGTDK---DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLR 205
+ K + LGL++ GG DG + + GG A ++ ++ GD I ++NG L L
Sbjct: 2753 VLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLM 2812
Query: 206 HDEIITLLKNVGE 218
H + ++K+V E
Sbjct: 2813 HFDAWNIMKSVPE 2825
Score = 38.9 bits (89), Expect = 0.028
Identities = 51/241 (21%), Positives = 87/241 (36%), Gaps = 45/241 (18%)
Query: 531 KSSLSLASSTVGPGGQIVHTETTEVV-LCGDPLSGFGLQLQGGIFATETLSSPPLVCFIE 589
KS+ SL+++ V +++ ++ L + G G + GG V I
Sbjct: 562 KSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGI-FVKTIF 620
Query: 590 PDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIP 649
P+ A G L+ GD +L +NGI + T +EA + V+ V+ S+ P
Sbjct: 621 PNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTP 680
Query: 650 SSGTFH------------------------------------------VKLPKKRSVELG 667
S H V L K+ V LG
Sbjct: 681 CSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLG 740
Query: 668 ITISSASRKRGEP-LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQ 726
I + + P + I + GSVA L GD++L ++++ + + + IL +
Sbjct: 741 IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSK 800
Query: 727 C 727
C
Sbjct: 801 C 801
Score = 37.7 bits (86), Expect = 0.063
Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 4/88 (4%)
Query: 758 KRYGGPLGITISGTEEPFDP---IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPL 814
K G LG +I+G + I + + G A G + GD IL +N + +KG
Sbjct: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
Query: 815 SEAIHLL-QVAGETVTLKIKKQLDRPLL 841
EAIH Q+ L ++ +L P L
Sbjct: 651 QEAIHTFKQIRSGLFVLTVRTKLVSPSL 678
Score = 33.5 bits (75), Expect = 1.2
Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 564 GFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEAN 623
G G+Q+ GG ++ +V ++ A R G L +GD +L ING + EEA
Sbjct: 343 GLGIQVSGGR-GSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAV 401
Query: 624 QLLRDAALAHKVVLEVEFDVAESVI 648
+LR A ++V+ + + AE ++
Sbjct: 402 AILRSATGMVQLVVASKENSAEDLL 426
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 72.4 bits (176), Expect = 2e-12
Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 27/194 (13%)
Query: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309
+EG GF L GGA + ++ + + V P G A +EG+++ G+ +LS++G L G +H
Sbjct: 1119 EEGAGLGFSLAGGADLE---NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175
Query: 310 ATALATLRQCSHEALFQVEYDVATP----------DTVANASGPLMVEIVKTP------- 352
ALA LRQ + TP D+ A+AS V + T
Sbjct: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTV 1235
Query: 353 -----GSALGISLT--TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405
+ LG SL SL +TI+RI + ++S + PGD IL + GT+M+
Sbjct: 1236 TLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
Query: 406 SLLEATKLLASISE 419
+ EA ++ ++ +
Sbjct: 1296 TRFEAWNIIKALPD 1309
Score = 63.9 bits (154), Expect = 8e-10
Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 22/196 (11%)
Query: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKP-RVSNLRPGGLAARSDLLNIGDYIRSV 196
++ GI V L K+EG+ LG +++GG D + K V + P GLA++ + G+ + S+
Sbjct: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165
Query: 197 NGIHLTRLRHDEIITLLKNVGE-RVVLEVEYELPPPA-PENNPRI-------------IS 241
NG L H + + +L+ E R + V +L P A P+ N +
Sbjct: 1166 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225
Query: 242 KTVD-----VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRL 296
T + V+L K GF L GG H +PL + + G +++ +++ GD +
Sbjct: 1226 STAEATVCTVTLEKMSAGLGFSLEGG-KGSLHGDKPLTINRIFKGAASEQSETVQPGDEI 1284
Query: 297 LSVDGIPLHGASHATA 312
L + G + G + A
Sbjct: 1285 LQLGGTAMQGLTRFEA 1300
Score = 51.6 bits (122), Expect = 4e-06
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 28/229 (12%)
Query: 634 KVVLEVEFDVAESVIPSSGTFHVK-LPKKRSVELGITISSASRKRGEPLIISDIKKGSVA 692
K++ EV+ + E+ + HV L K+ LG +++ + + + + + +A
Sbjct: 1092 KLIEEVKV-LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLA 1150
Query: 693 HRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCED-----LVKLKIRKD-----EDNS 742
+ GT++ G+++L+I+ L DA+ ILRQ + +V K+ + ++
Sbjct: 1151 SQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSST 1210
Query: 743 DELETTGAVS------------YTVELKRYGGPLGITISGTEEPF---DPIVISGLTKRG 787
D + A S TV L++ LG ++ G + P+ I+ + K
Sbjct: 1211 DSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGA 1270
Query: 788 LAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGE-TVTLKIKKQ 835
+E++ + GD IL + +++G EA ++++ + VT+ I+++
Sbjct: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
Score = 49.3 bits (116), Expect = 2e-05
Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 28/212 (13%)
Query: 563 SGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622
+G G L GG + + V + P+ A + G +Q G+ VLSING + + T +A
Sbjct: 1122 AGLGFSLAGGADLENKVIT---VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
Query: 623 NQLLRDAALAHKVV-------------LEVEFDVAESVIPSS---------GTFHVKLPK 660
+LR A + V L D A S +S T +
Sbjct: 1179 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLE 1238
Query: 661 KRSVELGITI--SSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPME 718
K S LG ++ S +PL I+ I KG+ + ++ T++PGD++L + +
Sbjct: 1239 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRF 1298
Query: 719 DAVQILRQCED-LVKLKIRKDEDNSDELETTG 749
+A I++ D V + IR+ S E G
Sbjct: 1299 EAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 1330
Score = 43.5 bits (101), Expect = 0.001
Identities = 64/275 (23%), Positives = 107/275 (38%), Gaps = 53/275 (19%)
Query: 227 ELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADR 286
+L P+ +IS V + +G F V G + + + + + GG A
Sbjct: 201 QLVQPSGGLQASVISNIVLMKGQAKGLGFSIV---GGKDSIYGPIGIYVKTIFAGGAAAA 257
Query: 287 EGSLKVGDRLLSVDGIPLHGASHATALATLRQ--------------------CSH----- 321
+G L+ GD +L ++G + G +H AL +Q CSH
Sbjct: 258 DGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPL 317
Query: 322 -------------EALFQVEYDVATPDTVANASGPLMVEIV--KTPGSALGISLTTTS-L 365
+ F +E A P + A + +MVE+ K G LGI L +
Sbjct: 318 CRSLSSSTCITKDSSSFALESPSA-PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYF 376
Query: 366 RNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425
+ S I + + P SV G L GD I+ I + + HC L + S + + I
Sbjct: 377 QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPV-HCLTLNEVYTILSHCDPGPVPI 435
Query: 426 L----PVPQ-SQRPLRP--QRQVVKVQRSEQLHRW 453
+ P PQ S++ L+ + V + ++ H+W
Sbjct: 436 IVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQW 470
Score = 41.2 bits (95), Expect = 0.006
Identities = 25/92 (27%), Positives = 43/92 (46%)
Query: 328 EYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGA 387
E V T+ G + + K G+ LG SL + VIT+ R+ P + + G
Sbjct: 1096 EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGT 1155
Query: 388 LHPGDHILSIDGTSMEHCSLLEATKLLASISE 419
+ G+ +LSI+G S++ + +A +L E
Sbjct: 1156 IQKGNEVLSINGKSLKGTTHHDALAILRQARE 1187
Score = 39.7 bits (91), Expect = 0.017
Identities = 63/273 (23%), Positives = 101/273 (36%), Gaps = 48/273 (17%)
Query: 533 SLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPP--LVCFIEP 590
SLS A V P G + + + +VL G G + GG +++ P V I
Sbjct: 196 SLSTAQ-LVQPSGGLQASVISNIVLMKGQAKGLGFSIVGG---KDSIYGPIGIYVKTIFA 251
Query: 591 DSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDA-----ALAHKVVLEVEFDVAE 645
A G LQ GD +L +NG + T ++A Q + A L + L +
Sbjct: 252 GGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCS 311
Query: 646 SVIP------SSGT----------------------------FHVKLPKKRSVELGITIS 671
+ P SS T V L K+ V LGI +
Sbjct: 312 HLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLC 371
Query: 672 SASRKRG-EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCE-- 728
S + + + + GSVAH G L GD+++ I + + + + IL C+
Sbjct: 372 SVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPG 431
Query: 729 DLVKLKIRKDEDNSDELETTGAVSYTVELKRYG 761
+ + R + E + AV+ VE ++G
Sbjct: 432 PVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFG 464
Score = 36.2 bits (82), Expect = 0.18
Identities = 51/217 (23%), Positives = 78/217 (35%), Gaps = 42/217 (19%)
Query: 143 ITVVELIKKEGSTLGLTISGGTDKDGKP---RVSNLRPGGLAARSDLLNIGDYIRSVNGI 199
I+ + L+K + LG +I GG D P V + GG AA L GD I +NG
Sbjct: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
Query: 200 HLTRLRHDEIITLLKNVGERVV-LEVEYELPPP-------APENNPRIISKT-------- 243
+ L H + + K + ++ L V L P +P + S T
Sbjct: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSS 333
Query: 244 --------------------VDVSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGG 282
V+VSL KE G G L + + + + PG
Sbjct: 334 FALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG--IFVHTLSPGS 391
Query: 283 PADREGSLKVGDRLLSVDGIPLHGASHATALATLRQC 319
A +G L+ GD ++ + P+H + L C
Sbjct: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428
>gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
Length = 631
Score = 72.4 bits (176), Expect = 2e-12
Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 27/194 (13%)
Query: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309
+EG GF L GGA + ++ + + V P G A +EG+++ G+ +LS++G L G +H
Sbjct: 418 EEGAGLGFSLAGGADLE---NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 474
Query: 310 ATALATLRQCSHEALFQVEYDVATP----------DTVANASGPLMVEIVKTP------- 352
ALA LRQ + TP D+ A+AS V + T
Sbjct: 475 HDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTV 534
Query: 353 -----GSALGISLT--TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405
+ LG SL SL +TI+RI + ++S + PGD IL + GT+M+
Sbjct: 535 TLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 594
Query: 406 SLLEATKLLASISE 419
+ EA ++ ++ +
Sbjct: 595 TRFEAWNIIKALPD 608
Score = 63.9 bits (154), Expect = 8e-10
Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 22/196 (11%)
Query: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKP-RVSNLRPGGLAARSDLLNIGDYIRSV 196
++ GI V L K+EG+ LG +++GG D + K V + P GLA++ + G+ + S+
Sbjct: 405 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 464
Query: 197 NGIHLTRLRHDEIITLLKNVGE-RVVLEVEYELPPPA-PENNPRI-------------IS 241
NG L H + + +L+ E R + V +L P A P+ N +
Sbjct: 465 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 524
Query: 242 KTVD-----VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRL 296
T + V+L K GF L GG H +PL + + G +++ +++ GD +
Sbjct: 525 STAEATVCTVTLEKMSAGLGFSLEGG-KGSLHGDKPLTINRIFKGAASEQSETVQPGDEI 583
Query: 297 LSVDGIPLHGASHATA 312
L + G + G + A
Sbjct: 584 LQLGGTAMQGLTRFEA 599
Score = 51.6 bits (122), Expect = 4e-06
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 28/229 (12%)
Query: 634 KVVLEVEFDVAESVIPSSGTFHVK-LPKKRSVELGITISSASRKRGEPLIISDIKKGSVA 692
K++ EV+ + E+ + HV L K+ LG +++ + + + + + +A
Sbjct: 391 KLIEEVKV-LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLA 449
Query: 693 HRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCED-----LVKLKIRKD-----EDNS 742
+ GT++ G+++L+I+ L DA+ ILRQ + +V K+ + ++
Sbjct: 450 SQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSST 509
Query: 743 DELETTGAVS------------YTVELKRYGGPLGITISGTEEPF---DPIVISGLTKRG 787
D + A S TV L++ LG ++ G + P+ I+ + K
Sbjct: 510 DSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGA 569
Query: 788 LAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGE-TVTLKIKKQ 835
+E++ + GD IL + +++G EA ++++ + VT+ I+++
Sbjct: 570 ASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
Score = 49.3 bits (116), Expect = 2e-05
Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 28/212 (13%)
Query: 563 SGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622
+G G L GG + + V + P+ A + G +Q G+ VLSING + + T +A
Sbjct: 421 AGLGFSLAGGADLENKVIT---VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 477
Query: 623 NQLLRDAALAHKVV-------------LEVEFDVAESVIPSS---------GTFHVKLPK 660
+LR A + V L D A S +S T +
Sbjct: 478 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLE 537
Query: 661 KRSVELGITI--SSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPME 718
K S LG ++ S +PL I+ I KG+ + ++ T++PGD++L + +
Sbjct: 538 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRF 597
Query: 719 DAVQILRQCED-LVKLKIRKDEDNSDELETTG 749
+A I++ D V + IR+ S E G
Sbjct: 598 EAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 629
Score = 41.2 bits (95), Expect = 0.006
Identities = 25/92 (27%), Positives = 43/92 (46%)
Query: 328 EYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGA 387
E V T+ G + + K G+ LG SL + VIT+ R+ P + + G
Sbjct: 395 EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGT 454
Query: 388 LHPGDHILSIDGTSMEHCSLLEATKLLASISE 419
+ G+ +LSI+G S++ + +A +L E
Sbjct: 455 IQKGNEVLSINGKSLKGTTHHDALAILRQARE 486
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 70.1 bits (170), Expect = 1e-11
Identities = 59/204 (28%), Positives = 96/204 (47%), Gaps = 35/204 (17%)
Query: 149 IKKEG-STLGLTISGGT-DKDGKPR--VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRL 204
+KKE +LG+T++GG K G+ V+++ P G AR + GD + ++NGI LT L
Sbjct: 471 VKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNL 530
Query: 205 RHDEIITLLKNVGERVV-----LEVEY---------ELPPPAPENN-------------- 236
H E + +LK LEV+ E P EN
Sbjct: 531 SHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLG 590
Query: 237 -PRIISKTVDVSLYKEG-NSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGD 294
P + D+ L + S+GF + GG +E+ H ++P + + G PA +G LK GD
Sbjct: 591 LPSTLHSCHDIVLRRSYLGSWGFSIVGG-YEENHTNQPFFIKTIVLGTPAYYDGRLKCGD 649
Query: 295 RLLSVDGIPLHGASHATALATLRQ 318
+++V+G+ G SH+ + L++
Sbjct: 650 MIVAVNGLSTVGMSHSALVPMLKE 673
Score = 60.8 bits (146), Expect = 7e-09
Identities = 54/199 (27%), Positives = 91/199 (45%), Gaps = 15/199 (7%)
Query: 664 VELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQI 723
++LGI+I + ++I ++ + V R G L GD++L ++N + N A +
Sbjct: 243 IQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAV 302
Query: 724 LRQCEDLVKLKIRKDE-------DNSDELETTGAVSYTVELKRYGGP-LGIT-ISGTEEP 774
L Q + + L + ++ ++SD + KR G LGI + T+EP
Sbjct: 303 LSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP 362
Query: 775 FDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKK 834
+ I L + GLA + G + DR+LAIN LK A ++Q +GE V L I
Sbjct: 363 --GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA- 419
Query: 835 QLDRPLLPRKSGSLSETSD 853
RP P+ ++ E +
Sbjct: 420 ---RPGKPQPGNTIREAGN 435
Score = 57.0 bits (136), Expect = 1e-07
Identities = 55/200 (27%), Positives = 92/200 (46%), Gaps = 36/200 (18%)
Query: 150 KKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEI 209
+ G LG+ + TD+ G + +L GGLAA+ L+ D + ++NG L +
Sbjct: 345 RDSGEQLGIKLVRRTDEPGV-FILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELA 403
Query: 210 ITLLKNVGERVVLEV----------------------EYELPPP---APENNPR----II 240
+++ GERV L + ++ PPP P ++ +
Sbjct: 404 AQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVT 463
Query: 241 SKTVDVSLYKEGN-SFGFVLRGGAHEDGHKS--RPLVLTYVRPGGPADREGSLKVGDRLL 297
+ +++ KE + S G + GG G KS P+ +T V P G R+G +K GD LL
Sbjct: 464 CQEKHITVKKEPHESLGMTVAGGR---GSKSGELPIFVTSVPPHGCLARDGRIKRGDVLL 520
Query: 298 SVDGIPLHGASHATALATLR 317
+++GI L SH+ A+A L+
Sbjct: 521 NINGIDLTNLSHSEAVAMLK 540
Score = 43.5 bits (101), Expect = 0.001
Identities = 82/359 (22%), Positives = 144/359 (40%), Gaps = 65/359 (18%)
Query: 120 KDAGGADVSLACRRQSIPEEFRGITVVELIKKEGST-LGLTISGGTDKDG-KPRVSNLRP 177
+++ GAD + + S+PE IT +E+ + LG++I GG + + +
Sbjct: 212 EESAGADTTQ--QPLSLPEG--EITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYR 267
Query: 178 GGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYE------LPPP 231
G+ AR L GD I VN +++ + H+ +L + L V E
Sbjct: 268 DGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNH 327
Query: 232 APENNPRIISKTVDVSLYKE--GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGS 289
+ N+PR + V+L+K G G L E G + + + GG A ++G
Sbjct: 328 SDSNSPR--EEIFQVALHKRDSGEQLGIKLVRRTDEPG-----VFILDLLEGGLAAQDGR 380
Query: 290 LKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATP------DTVANASGP 343
L DR+L+++G L + A A + Q S E +V +A P +T+ A
Sbjct: 381 LSSNDRVLAINGHDLKYGTPELA-AQIIQASGE---RVNLTIARPGKPQPGNTIREAGNH 436
Query: 344 LM------------------------------VEIVKTPGSALGISLT--TTSLRNKSVI 371
+ + K P +LG+++ S + I
Sbjct: 437 SSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPI 496
Query: 372 TIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLL--ASISEKVRLEILPV 428
+ + P + R G + GD +L+I+G + + S EA +L ++ S V L+ L V
Sbjct: 497 FVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEV 555
Score = 38.5 bits (88), Expect = 0.037
Identities = 49/199 (24%), Positives = 80/199 (40%), Gaps = 13/199 (6%)
Query: 273 LVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVA 332
+V+ V G R+G L GD++L V+ + SH A A L Q + V +
Sbjct: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERR 319
Query: 333 TPDTVANASGP-------LMVEIVK-TPGSALGISLTTTSLRNKSVITIDRIKPASVVDR 384
+ N S V + K G LGI L + V +D ++ + +
Sbjct: 320 FGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRT-DEPGVFILDLLE-GGLAAQ 377
Query: 385 SGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQRQVVKV 444
G L D +L+I+G +++ + A +++ + E+V L I P +P R+
Sbjct: 378 DGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR-PGKPQPGNTIREAGNH 436
Query: 445 QRSEQLHRWDPCV--PSCH 461
S Q H P PS H
Sbjct: 437 SSSSQHHTPPPYYSRPSSH 455
Score = 30.8 bits (68), Expect = 7.7
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 554 EVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIA 613
++VL L +G + GG T + P + I +PA G L+ GD ++++NG++
Sbjct: 600 DIVLRRSYLGSWGFSIVGGYEENHT-NQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLS 658
Query: 614 T 614
T
Sbjct: 659 T 659
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,800,539
Number of Sequences: 37866
Number of extensions: 2890638
Number of successful extensions: 11786
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 147
Number of HSP's successfully gapped in prelim test: 262
Number of HSP's that attempted gapping in prelim test: 9532
Number of HSP's gapped (non-prelim): 2196
length of query: 1141
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1028
effective length of database: 13,968,660
effective search space: 14359782480
effective search space used: 14359782480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.