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Search of human proteins with 28467003
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28467003 kinase interacting stathmin [Homo sapiens]
(419 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28467003 kinase interacting stathmin [Homo sapiens] 853 0.0
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 82 1e-15
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 82 1e-15
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 80 4e-15
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 80 4e-15
gi|60279268 U2 (RNU2) small nuclear RNA auxiliary factor 2 isofo... 79 8e-15
gi|6005926 U2 (RNU2) small nuclear RNA auxiliary factor 2 isofor... 79 8e-15
gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens] 77 2e-14
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 77 3e-14
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 77 3e-14
gi|23308722 TTK protein kinase [Homo sapiens] 77 4e-14
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 77 4e-14
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 76 6e-14
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 75 8e-14
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 75 8e-14
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 75 8e-14
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 75 8e-14
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 75 8e-14
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 75 8e-14
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 75 8e-14
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 75 8e-14
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 75 1e-13
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 75 1e-13
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 74 2e-13
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 72 7e-13
gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens] 72 7e-13
gi|33383241 protein kinase Myt1 isoform 1 [Homo sapiens] 72 7e-13
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 71 2e-12
gi|7657498 MAPK/MAK/MRK overlapping kinase [Homo sapiens] 70 4e-12
gi|156105707 SNF related kinase [Homo sapiens] 69 6e-12
>gi|28467003 kinase interacting stathmin [Homo sapiens]
Length = 419
Score = 853 bits (2205), Expect = 0.0
Identities = 419/419 (100%), Positives = 419/419 (100%)
Query: 1 MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPG 60
MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPG
Sbjct: 1 MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPG 60
Query: 61 TTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSE 120
TTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSE
Sbjct: 61 TTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSE 120
Query: 121 LLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL 180
LLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL
Sbjct: 121 LLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL 180
Query: 181 SFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMK 240
SFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMK
Sbjct: 181 SFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMK 240
Query: 241 LKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALC 300
LKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALC
Sbjct: 241 LKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALC 300
Query: 301 SPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSL 360
SPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSL
Sbjct: 301 SPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSL 360
Query: 361 LVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL 419
LVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL
Sbjct: 361 LVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL 419
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 81.6 bits (200), Expect = 1e-15
Identities = 54/148 (36%), Positives = 77/148 (52%), Gaps = 15/148 (10%)
Query: 98 IHFSPNVPSR---CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGY 154
IH N R C+ ELL +++ EL+ + QG S+ +++ A +L+ L LH
Sbjct: 285 IHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRI 344
Query: 155 VHADLKPRNILWSAENEC-FKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGL 213
+H DLKP NIL + K+IDFG S E + YIQ+ YRAPE L A+ G+
Sbjct: 345 IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILG---ARYGM 401
Query: 214 QSDTECTSAVDLWSLGIILLEMFSGMKL 241
+D+WSLG IL E+ +G L
Sbjct: 402 --------PIDMWSLGCILAELLTGYPL 421
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 81.6 bits (200), Expect = 1e-15
Identities = 54/148 (36%), Positives = 77/148 (52%), Gaps = 15/148 (10%)
Query: 98 IHFSPNVPSR---CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGY 154
IH N R C+ ELL +++ EL+ + QG S+ +++ A +L+ L LH
Sbjct: 212 IHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRI 271
Query: 155 VHADLKPRNILWSAENEC-FKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGL 213
+H DLKP NIL + K+IDFG S E + YIQ+ YRAPE L A+ G+
Sbjct: 272 IHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILG---ARYGM 328
Query: 214 QSDTECTSAVDLWSLGIILLEMFSGMKL 241
+D+WSLG IL E+ +G L
Sbjct: 329 --------PIDMWSLGCILAELLTGYPL 348
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 79.7 bits (195), Expect = 4e-15
Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 17/158 (10%)
Query: 85 GHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLE 144
G N++ + FT F +V C+ ELL + + EL+ + QG S+ +++ A+ +L+
Sbjct: 247 GSMNVIHMLESFT--FRNHV---CMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 301
Query: 145 ALAFLHHEGYVHADLKPRNILWSAE-NECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAE 203
+L LH +H DLKP NIL K+IDFG S E + YIQ+ YRAPE
Sbjct: 302 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEII 361
Query: 204 LQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKL 241
L + ++ +D+WS G IL E+ +G L
Sbjct: 362 L-----------GSRYSTPIDIWSFGCILAELLTGQPL 388
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 79.7 bits (195), Expect = 4e-15
Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 17/158 (10%)
Query: 85 GHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLE 144
G N++ + FT F +V C+ ELL + + EL+ + QG S+ +++ A+ +L+
Sbjct: 267 GSMNVIHMLESFT--FRNHV---CMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321
Query: 145 ALAFLHHEGYVHADLKPRNILWSAE-NECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAE 203
+L LH +H DLKP NIL K+IDFG S E + YIQ+ YRAPE
Sbjct: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEII 381
Query: 204 LQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKL 241
L + ++ +D+WS G IL E+ +G L
Sbjct: 382 L-----------GSRYSTPIDIWSFGCILAELLTGQPL 408
>gi|60279268 U2 (RNU2) small nuclear RNA auxiliary factor 2 isoform
b [Homo sapiens]
Length = 471
Score = 79.0 bits (193), Expect = 8e-15
Identities = 41/98 (41%), Positives = 63/98 (64%), Gaps = 5/98 (5%)
Query: 319 PTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPK-----ENPGRGQVF 373
PT VL L+N++ + L ++EEYE++VEDV++EC KYG V S+ +P+ E PG G++F
Sbjct: 370 PTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIF 429
Query: 374 VEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKR 411
VE+ + D + A + LTGR F + VV + +Y R
Sbjct: 430 VEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHR 467
>gi|6005926 U2 (RNU2) small nuclear RNA auxiliary factor 2 isoform a
[Homo sapiens]
Length = 475
Score = 79.0 bits (193), Expect = 8e-15
Identities = 41/98 (41%), Positives = 63/98 (64%), Gaps = 5/98 (5%)
Query: 319 PTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPK-----ENPGRGQVF 373
PT VL L+N++ + L ++EEYE++VEDV++EC KYG V S+ +P+ E PG G++F
Sbjct: 374 PTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIF 433
Query: 374 VEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKR 411
VE+ + D + A + LTGR F + VV + +Y R
Sbjct: 434 VEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHR 471
>gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens]
Length = 406
Score = 77.4 bits (189), Expect = 2e-14
Identities = 74/250 (29%), Positives = 104/250 (41%), Gaps = 52/250 (20%)
Query: 74 RKERAALEQLQGHRNIVTLYGVF-TIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSM 132
R+E L Q+ GH +I+TL + + F V EL D ++ L M
Sbjct: 75 RRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIM 134
Query: 133 WMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLS--FKEGNQDVK 190
R +LEA++FLH VH DLKP NIL +N +L DFG S + G + +
Sbjct: 135 -------RSLLEAVSFLHANNIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKLRE 186
Query: 191 YIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSG------------ 238
T GY AP E+ C ++ VDLW+ G+IL + +G
Sbjct: 187 LCGTPGYLAP--EILKCSMD---ETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILM 241
Query: 239 ----MKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIP 294
M+ ++ S EW SS + +DLI +L DP R+
Sbjct: 242 LRMIMEGQYQFSSPEWDDRSSTV--------------------KDLISRLLQVDPEARLT 281
Query: 295 AEMALCSPFF 304
AE AL PFF
Sbjct: 282 AEQALQHPFF 291
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 77.0 bits (188), Expect = 3e-14
Identities = 84/307 (27%), Positives = 125/307 (40%), Gaps = 44/307 (14%)
Query: 23 WQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQ 82
++ + +G G+ V++ R N G + + G G S +E A L
Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-----REVAVLRH 67
Query: 83 LQG--HRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCAR 140
L+ H N+V L+ V T+ + L+ E +D ++ L G I+
Sbjct: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127
Query: 141 DVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL----SFKEGNQDVKYIQTDG 196
+L L FLH VH DLKP+NIL ++ + KL DFGL SF+ V + T
Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-IKLADFGLARIYSFQMALTSV--VVTLW 184
Query: 197 YRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSA 256
YRAPE LQ+ A + VDLWS+G I EMF L +
Sbjct: 185 YRAPEVLLQSSYA-----------TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233
Query: 257 IIDHIFASKAVVNAAIP--AYHL-----------------RDLIKSMLHDDPSRRIPAEM 297
+I + A+P A+H +DL+ L +P++RI A
Sbjct: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293
Query: 298 ALCSPFF 304
AL P+F
Sbjct: 294 ALSHPYF 300
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 77.0 bits (188), Expect = 3e-14
Identities = 84/307 (27%), Positives = 125/307 (40%), Gaps = 44/307 (14%)
Query: 23 WQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQ 82
++ + +G G+ V++ R N G + + G G S +E A L
Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-----REVAVLRH 67
Query: 83 LQG--HRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCAR 140
L+ H N+V L+ V T+ + L+ E +D ++ L G I+
Sbjct: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127
Query: 141 DVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL----SFKEGNQDVKYIQTDG 196
+L L FLH VH DLKP+NIL ++ + KL DFGL SF+ V + T
Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-IKLADFGLARIYSFQMALTSV--VVTLW 184
Query: 197 YRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSA 256
YRAPE LQ+ A + VDLWS+G I EMF L +
Sbjct: 185 YRAPEVLLQSSYA-----------TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233
Query: 257 IIDHIFASKAVVNAAIP--AYHL-----------------RDLIKSMLHDDPSRRIPAEM 297
+I + A+P A+H +DL+ L +P++RI A
Sbjct: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293
Query: 298 ALCSPFF 304
AL P+F
Sbjct: 294 ALSHPYF 300
>gi|23308722 TTK protein kinase [Homo sapiens]
Length = 857
Score = 76.6 bits (187), Expect = 4e-14
Identities = 79/297 (26%), Positives = 132/297 (44%), Gaps = 27/297 (9%)
Query: 20 GRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAA 79
GR++ + ++GSG S+ V++V N A+K A + +R E A
Sbjct: 522 GRIYSILKQIGSGGSSKVFQVL---NEKKQIYAIKYV----NLEEADNQTLDSYRNEIAY 574
Query: 80 LEQLQGHRN-IVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHC 138
L +LQ H + I+ LY + +++E ++ ++ L + W +
Sbjct: 575 LNKLQQHSDKIIRLYD-----YEITDQYIYMVMECGNIDLNSWL--KKKKSIDPWERKSY 627
Query: 139 ARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQ----- 193
+++LEA+ +H G VH+DLKP N L + KLIDFG++ + ++
Sbjct: 628 WKNMLEAVHTIHQHGIVHSDLKPANFL--IVDGMLKLIDFGIANQMQPDTTSVVKDSQVG 685
Query: 194 TDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKAN 253
T Y PEA ++ +S ++ + D+WSLG IL M G + +Q K +
Sbjct: 686 TVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLH 745
Query: 254 SSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAP 310
AIID + + IP L+D++K L DP +RI L P+ I P
Sbjct: 746 --AIID---PNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 797
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 76.6 bits (187), Expect = 4e-14
Identities = 49/135 (36%), Positives = 72/135 (53%), Gaps = 12/135 (8%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNI-LW 166
C+ ELL +++ EL+ ++ QG S+ +++ VL+ L L E +H DLKP NI L+
Sbjct: 180 CITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLY 239
Query: 167 SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLW 226
K+IDFG S E + YIQ+ YR+PE L G D A+D+W
Sbjct: 240 QKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVIL-------GHPYDV----AIDMW 288
Query: 227 SLGIILLEMFSGMKL 241
SLG I E+++G L
Sbjct: 289 SLGCITAELYTGYPL 303
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 75.9 bits (185), Expect = 6e-14
Identities = 84/295 (28%), Positives = 130/295 (44%), Gaps = 43/295 (14%)
Query: 17 EAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKE 76
+A ++V+S LG G+++ VYR + G P ALK + + R E
Sbjct: 40 DALSDFFEVESELGRGATSIVYRCKQKGT--QKPYALKVL--------KKTVDKKIVRTE 89
Query: 77 RAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLL----ELLDVSVSELLLYSSHQGCSM 132
L +L H NI+ L +F +P S L L EL D + E YS
Sbjct: 90 IGVLLRLS-HPNIIKLKEIFE---TPTEISLVLELVTGGELFD-RIVEKGYYSERDAAD- 143
Query: 133 WMIQHCARDVLEALAFLHHEGYVHADLKPRNILWS--AENECFKLIDFGLSFKEGNQDV- 189
+ +LEA+A+LH G VH DLKP N+L++ A + K+ DFGLS +Q +
Sbjct: 144 -----AVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLM 198
Query: 190 -KYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQ 248
T GY APE L+ C VD+WS+GII + G + + R
Sbjct: 199 KTVCGTPGYCAPEI-LRGC----------AYGPEVDMWSVGIITYILLCGFEPFYDERGD 247
Query: 249 EWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPF 303
++ ++ F S ++ A +DL++ ++ DP +R+ AL P+
Sbjct: 248 QFMFRRILNCEYYFISPWWDEVSLNA---KDLVRKLIVLDPKKRLTTFQALQHPW 299
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/137 (35%), Positives = 74/137 (54%), Gaps = 14/137 (10%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHE--GYVHADLKPRNIL 165
CL+ ELL ++ +LL + +G S+ + + A+ + AL FL +H DLKP NIL
Sbjct: 187 CLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENIL 246
Query: 166 W-SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVD 224
+ + K++DFG S + G + +YIQ+ YR+PE L T A+D
Sbjct: 247 LCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL-----------GTPYDLAID 295
Query: 225 LWSLGIILLEMFSGMKL 241
+WSLG IL+EM +G L
Sbjct: 296 MWSLGCILVEMHTGEPL 312
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/137 (35%), Positives = 74/137 (54%), Gaps = 14/137 (10%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHE--GYVHADLKPRNIL 165
CL+ ELL ++ +LL + +G S+ + + A+ + AL FL +H DLKP NIL
Sbjct: 187 CLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENIL 246
Query: 166 W-SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVD 224
+ + K++DFG S + G + +YIQ+ YR+PE L T A+D
Sbjct: 247 LCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL-----------GTPYDLAID 295
Query: 225 LWSLGIILLEMFSGMKL 241
+WSLG IL+EM +G L
Sbjct: 296 MWSLGCILVEMHTGEPL 312
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/137 (35%), Positives = 74/137 (54%), Gaps = 14/137 (10%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHE--GYVHADLKPRNIL 165
CL+ ELL ++ +LL + +G S+ + + A+ + AL FL +H DLKP NIL
Sbjct: 187 CLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENIL 246
Query: 166 W-SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVD 224
+ + K++DFG S + G + +YIQ+ YR+PE L T A+D
Sbjct: 247 LCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL-----------GTPYDLAID 295
Query: 225 LWSLGIILLEMFSGMKL 241
+WSLG IL+EM +G L
Sbjct: 296 MWSLGCILVEMHTGEPL 312
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/137 (35%), Positives = 77/137 (56%), Gaps = 14/137 (10%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHE--GYVHADLKPRNIL 165
CL+ E+L ++ +LL ++ +G S+ + + A+ + AL FL +H DLKP NIL
Sbjct: 235 CLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENIL 294
Query: 166 W-SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVD 224
+ + K++DFG S + G + +YIQ+ YR+PE L G+ D A+D
Sbjct: 295 LCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL-------GMPYDL----AID 343
Query: 225 LWSLGIILLEMFSGMKL 241
+WSLG IL+EM +G L
Sbjct: 344 MWSLGCILVEMHTGEPL 360
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/137 (35%), Positives = 77/137 (56%), Gaps = 14/137 (10%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHE--GYVHADLKPRNIL 165
CL+ E+L ++ +LL ++ +G S+ + + A+ + AL FL +H DLKP NIL
Sbjct: 235 CLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENIL 294
Query: 166 W-SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVD 224
+ + K++DFG S + G + +YIQ+ YR+PE L G+ D A+D
Sbjct: 295 LCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL-------GMPYDL----AID 343
Query: 225 LWSLGIILLEMFSGMKL 241
+WSLG IL+EM +G L
Sbjct: 344 MWSLGCILVEMHTGEPL 360
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/137 (35%), Positives = 77/137 (56%), Gaps = 14/137 (10%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHE--GYVHADLKPRNIL 165
CL+ E+L ++ +LL ++ +G S+ + + A+ + AL FL +H DLKP NIL
Sbjct: 235 CLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENIL 294
Query: 166 W-SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVD 224
+ + K++DFG S + G + +YIQ+ YR+PE L G+ D A+D
Sbjct: 295 LCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL-------GMPYDL----AID 343
Query: 225 LWSLGIILLEMFSGMKL 241
+WSLG IL+EM +G L
Sbjct: 344 MWSLGCILVEMHTGEPL 360
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/137 (35%), Positives = 77/137 (56%), Gaps = 14/137 (10%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHE--GYVHADLKPRNIL 165
CL+ E+L ++ +LL ++ +G S+ + + A+ + AL FL +H DLKP NIL
Sbjct: 226 CLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENIL 285
Query: 166 W-SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVD 224
+ + K++DFG S + G + +YIQ+ YR+PE L G+ D A+D
Sbjct: 286 LCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL-------GMPYDL----AID 334
Query: 225 LWSLGIILLEMFSGMKL 241
+WSLG IL+EM +G L
Sbjct: 335 MWSLGCILVEMHTGEPL 351
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 75.5 bits (184), Expect = 8e-14
Identities = 49/137 (35%), Positives = 77/137 (56%), Gaps = 14/137 (10%)
Query: 108 CLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHE--GYVHADLKPRNIL 165
CL+ E+L ++ +LL ++ +G S+ + + A+ + AL FL +H DLKP NIL
Sbjct: 235 CLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENIL 294
Query: 166 W-SAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVD 224
+ + K++DFG S + G + +YIQ+ YR+PE L G+ D A+D
Sbjct: 295 LCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL-------GMPYDL----AID 343
Query: 225 LWSLGIILLEMFSGMKL 241
+WSLG IL+EM +G L
Sbjct: 344 MWSLGCILVEMHTGEPL 360
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 74.7 bits (182), Expect = 1e-13
Identities = 76/254 (29%), Positives = 113/254 (44%), Gaps = 44/254 (17%)
Query: 65 AASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLL----ELLDVSVSE 120
A E E A L +++ H NIV L ++ SPN + L EL D + E
Sbjct: 58 ALKGKESSIENEIAVLRKIK-HENIVALEDIYE---SPNHLYLVMQLVSGGELFD-RIVE 112
Query: 121 LLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLI--DF 178
Y+ ++ R VL+A+ +LH G VH DLKP N+L+ +++E K++ DF
Sbjct: 113 KGFYTEKDASTL------IRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDF 166
Query: 179 GLSFKEGNQDVKYIQ--TDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMF 236
GLS EG DV T GY APE LAQ + AVD WS+G+I +
Sbjct: 167 GLSKMEGKGDVMSTACGTPGYVAPEV-----LAQ------KPYSKAVDCWSIGVIAYILL 215
Query: 237 SGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAY-----HLRDLIKSMLHDDPSR 291
G + N S + + I KA P + +D I++++ DP++
Sbjct: 216 CGY-------PPFYDENDSKLFEQIL--KAEYEFDSPYWDDISDSAKDFIRNLMEKDPNK 266
Query: 292 RIPAEMALCSPFFS 305
R E A P+ +
Sbjct: 267 RYTCEQAARHPWIA 280
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 74.7 bits (182), Expect = 1e-13
Identities = 76/254 (29%), Positives = 113/254 (44%), Gaps = 44/254 (17%)
Query: 65 AASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLL----ELLDVSVSE 120
A E E A L +++ H NIV L ++ SPN + L EL D + E
Sbjct: 58 ALKGKESSIENEIAVLRKIK-HENIVALEDIYE---SPNHLYLVMQLVSGGELFD-RIVE 112
Query: 121 LLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLI--DF 178
Y+ ++ R VL+A+ +LH G VH DLKP N+L+ +++E K++ DF
Sbjct: 113 KGFYTEKDASTL------IRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDF 166
Query: 179 GLSFKEGNQDVKYIQ--TDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMF 236
GLS EG DV T GY APE LAQ + AVD WS+G+I +
Sbjct: 167 GLSKMEGKGDVMSTACGTPGYVAPEV-----LAQ------KPYSKAVDCWSIGVIAYILL 215
Query: 237 SGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAY-----HLRDLIKSMLHDDPSR 291
G + N S + + I KA P + +D I++++ DP++
Sbjct: 216 CGY-------PPFYDENDSKLFEQIL--KAEYEFDSPYWDDISDSAKDFIRNLMEKDPNK 266
Query: 292 RIPAEMALCSPFFS 305
R E A P+ +
Sbjct: 267 RYTCEQAARHPWIA 280
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 73.9 bits (180), Expect = 2e-13
Identities = 89/339 (26%), Positives = 138/339 (40%), Gaps = 54/339 (15%)
Query: 28 RLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHR 87
++G GS V++ C A+K+FL A +E L+QL+ H
Sbjct: 10 KIGEGSYGVVFK--CRNRDTGQIVAIKKFLESEDDPVIKKIA----LREIRMLKQLK-HP 62
Query: 88 NIVTLYGVFT----IHFSPNVPSRCLLLELLDVSV-SELLLYSSHQGCSMWMIQHCARDV 142
N+V L VF +H L+ E D +V EL Y +G +++
Sbjct: 63 NLVNLLEVFRRKRRLH---------LVFEYCDHTVLHELDRYQ--RGVPEHLVKSITWQT 111
Query: 143 LEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLS-FKEGNQD--VKYIQTDGYRA 199
L+A+ F H +H D+KP NIL ++ KL DFG + G D Y+ T YR+
Sbjct: 112 LQAVNFCHKHNCIHRDVKPENIL-ITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRS 170
Query: 200 PEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIID 259
PE L DT+ VD+W++G + E+ SG+ L W S +D
Sbjct: 171 PEL----------LVGDTQYGPPVDVWAIGCVFAELLSGVPL--------WPGKSD--VD 210
Query: 260 HIFASKAVVNAAIP----AYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIED- 314
++ + + IP + + DP P E+ P S P ++
Sbjct: 211 QLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKF--PNISYPALGLLKGC 268
Query: 315 LVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQK 353
L M PT L +L Y EN E ED+ ++ + +K
Sbjct: 269 LHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRK 307
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 72.4 bits (176), Expect = 7e-13
Identities = 76/237 (32%), Positives = 112/237 (47%), Gaps = 35/237 (14%)
Query: 70 EYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVS-VSELLLYSSHQ 128
E +KE AL+ +GH NIV L+ VF L++ELL+ + E + H
Sbjct: 462 EANTQKEITALKLCEGHPNIVKLHEVFHDQLHT-----FLVMELLNGGELFERIKKKKH- 515
Query: 129 GCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENEC--FKLIDFGLSFKE-- 184
S + R ++ A++ +H G VH DLKP N+L++ EN+ K+IDFG + +
Sbjct: 516 -FSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPP 574
Query: 185 GNQDVKY-IQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKH 243
NQ +K T Y APE QN D C DLWSLG+IL M SG ++
Sbjct: 575 DNQPLKTPCFTLHYAAPELLNQN-------GYDESC----DLWSLGVILYTMLSG-QVPF 622
Query: 244 TVRSQEWKANSSAII-------DHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRI 293
+ S+ I D F +A N + A +DLI+ +L DP++R+
Sbjct: 623 QSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA---KDLIQGLLTVDPNKRL 676
Score = 58.9 bits (141), Expect = 8e-09
Identities = 69/269 (25%), Positives = 117/269 (43%), Gaps = 25/269 (9%)
Query: 29 LGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRN 88
LG+G+ V+ VR + + L T A E+ R ER LE ++
Sbjct: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHT-RTERQVLEHIRQSPF 113
Query: 89 IVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAF 148
+VTL+ F ++ + L +S+ ++ H+ +Q +++ AL
Sbjct: 114 LVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHE------VQIYVGEIVLALEH 167
Query: 149 LHHEGYVHADLKPRNILWSAENECFKLIDFGLSFK----EGNQDVKYIQTDGYRAPEAEL 204
LH G ++ D+K NIL + L DFGLS + E + + T Y AP+
Sbjct: 168 LHKLGIIYRDIKLENILLDSNGHVV-LTDFGLSKEFVADETERAYSFCGTIEYMAPD--- 223
Query: 205 QNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFAS 264
+ + G D+ AVD WSLG+++ E+ +G TV + K + + I I S
Sbjct: 224 ---IVRGG---DSGHDKAVDWWSLGVLMYELLTGAS-PFTVDGE--KNSQAEISRRILKS 274
Query: 265 KAVVNAAIPAYHLRDLIKSMLHDDPSRRI 293
+ + A +DLI+ +L DP +R+
Sbjct: 275 EPPYPQEMSAL-AKDLIQRLLMKDPKKRL 302
>gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens]
Length = 480
Score = 72.4 bits (176), Expect = 7e-13
Identities = 90/312 (28%), Positives = 122/312 (39%), Gaps = 54/312 (17%)
Query: 9 GAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPP--GTTGAAA 66
G +P R F + +Q SRLG GS V++VR A+K+ + P G A
Sbjct: 96 GYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVR--SKEDGRLYAVKRSMSPFRGPKDRAR 153
Query: 67 SAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSS 126
AE G E++ H V L + L L+ +EL S
Sbjct: 154 KLAEVGSH------EKVGQHPCCVRLEQAWE-------EGGILYLQ------TELCGPSL 194
Query: 127 HQGCSMW-------MIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFG 179
Q C W + RD L ALA LH +G VH D+KP NI C KL DFG
Sbjct: 195 QQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRC-KLGDFG 253
Query: 180 LSFKEGNQDVKYIQTDG--YRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFS 237
L + G +Q Y APE LQ +A D++SLG+ +LE+
Sbjct: 254 LLVELGTAGAGEVQEGDPRYMAPEL-LQGSYG-----------TAADVFSLGLTILEVAC 301
Query: 238 GMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEM 297
M+L H + W+ + F + + LR ++ ML DP R AE
Sbjct: 302 NMELPH--GGEGWQQLRQGYLPPEFTAGL-------SSELRSVLVMMLEPDPKLRATAEA 352
Query: 298 ALCSPFFSIPFA 309
L P P A
Sbjct: 353 LLALPVLRQPRA 364
>gi|33383241 protein kinase Myt1 isoform 1 [Homo sapiens]
Length = 499
Score = 72.4 bits (176), Expect = 7e-13
Identities = 90/312 (28%), Positives = 122/312 (39%), Gaps = 54/312 (17%)
Query: 9 GAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPP--GTTGAAA 66
G +P R F + +Q SRLG GS V++VR A+K+ + P G A
Sbjct: 96 GYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVR--SKEDGRLYAVKRSMSPFRGPKDRAR 153
Query: 67 SAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSS 126
AE G E++ H V L + L L+ +EL S
Sbjct: 154 KLAEVGSH------EKVGQHPCCVRLEQAWE-------EGGILYLQ------TELCGPSL 194
Query: 127 HQGCSMW-------MIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFG 179
Q C W + RD L ALA LH +G VH D+KP NI C KL DFG
Sbjct: 195 QQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRC-KLGDFG 253
Query: 180 LSFKEGNQDVKYIQTDG--YRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFS 237
L + G +Q Y APE LQ +A D++SLG+ +LE+
Sbjct: 254 LLVELGTAGAGEVQEGDPRYMAPEL-LQGSYG-----------TAADVFSLGLTILEVAC 301
Query: 238 GMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEM 297
M+L H + W+ + F + + LR ++ ML DP R AE
Sbjct: 302 NMELPH--GGEGWQQLRQGYLPPEFTAGL-------SSELRSVLVMMLEPDPKLRATAEA 352
Query: 298 ALCSPFFSIPFA 309
L P P A
Sbjct: 353 LLALPVLRQPRA 364
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 71.2 bits (173), Expect = 2e-12
Identities = 82/308 (26%), Positives = 127/308 (41%), Gaps = 51/308 (16%)
Query: 75 KERAALEQLQGHRNIVTLYGVFTIHFS-PNVPSRCLLLELLDVSVSELLLYSSHQGCSMW 133
+E L+ +Q H N++ L VFT S N L++ + + +++ S
Sbjct: 71 RELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM----GMEFSEE 125
Query: 134 MIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQ 193
IQ+ +L+ L ++H G VH DLKP N+ + + E K++DFGL+ + Y+
Sbjct: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARHADAEMTGYVV 184
Query: 194 TDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMK------------- 240
T YRAPE L S VD+WS+G I+ EM +G
Sbjct: 185 TRWYRAPEVIL----------SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234
Query: 241 -LKHT-VRSQEW--KANSSAIIDHIFASKAVVNAAIPAYHLR------DLIKSMLHDDPS 290
LK T V E+ K N A +I + R DL++ ML D
Sbjct: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294
Query: 291 RRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEE-EYEDVVEDVKE 349
+R+ A AL PFF P E P DD LE+E+ ++ + + +
Sbjct: 295 KRLTAAQALTHPFFEPFRDPEEETEAQQPF----------DDSLEHEKLTVDEWKQHIYK 344
Query: 350 ECQKYGPV 357
E + P+
Sbjct: 345 EIVNFSPI 352
>gi|7657498 MAPK/MAK/MRK overlapping kinase [Homo sapiens]
Length = 419
Score = 70.1 bits (170), Expect = 4e-12
Identities = 74/253 (29%), Positives = 103/253 (40%), Gaps = 39/253 (15%)
Query: 75 KERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWM 134
+E AL +L H NI+ L+ V F S L+ EL+D+++ EL+ + S
Sbjct: 49 REIQALRRLNPHPNILMLHEVV---FDRKSGSLALICELMDMNIYELIRGRRYP-LSEKK 104
Query: 135 IQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFG--LSFKEGNQDVKYI 192
I H + ++L +H G H D+KP NIL + + KL DFG S +YI
Sbjct: 105 IMHYMYQLCKSLDHIHRNGIFHRDVKPENIL--IKQDVLKLGDFGSCRSVYSKQPYTEYI 162
Query: 193 QTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQE--- 249
T YRAPE CL G T +DLWS G + E+ S L V +
Sbjct: 163 STRWYRAPE-----CLLTDGFY-----TYKMDLWSAGCVFYEIASLQPLFPGVNELDQIS 212
Query: 250 --------------WKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHD----DPSR 291
K S ++ F K + +L S+LH DP
Sbjct: 213 KIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDE 272
Query: 292 RIPAEMALCSPFF 304
RI A AL P+F
Sbjct: 273 RIAAHQALQHPYF 285
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 69.3 bits (168), Expect = 6e-12
Identities = 63/217 (29%), Positives = 92/217 (42%), Gaps = 25/217 (11%)
Query: 82 QLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARD 141
+L H NIV LY V L+LEL D + +G + + +
Sbjct: 68 KLVQHPNIVRLYEVIDTQ-----TKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122
Query: 142 VLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLS--FKEGNQDVKYIQTDGYRA 199
++ A+++ H VH DLKP N+++ + KL DFG S F+ G + + Y A
Sbjct: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 182
Query: 200 PEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIID 259
PE L D AVD+WSLG+IL + G + +AN S +
Sbjct: 183 PEI----------LLGDEYDAPAVDIWSLGVILFMLVCG-------QPPFQEANDSETLT 225
Query: 260 HIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAE 296
I K V + + + +DLI ML DP RR E
Sbjct: 226 MIMDCKYTVPSHV-SKECKDLITRMLQRDPKRRASLE 261
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,380,459
Number of Sequences: 37866
Number of extensions: 823192
Number of successful extensions: 4403
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 414
Number of HSP's successfully gapped in prelim test: 382
Number of HSP's that attempted gapping in prelim test: 3023
Number of HSP's gapped (non-prelim): 1024
length of query: 419
length of database: 18,247,518
effective HSP length: 105
effective length of query: 314
effective length of database: 14,271,588
effective search space: 4481278632
effective search space used: 4481278632
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.