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Search of human proteins with 27502413
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27502413 CD46 antigen, complement regulatory protein isoform
7 precursor [Homo sapiens]
(378 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 805 0.0
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 795 0.0
gi|27502425 CD46 antigen, complement regulatory protein isoform ... 773 0.0
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 764 0.0
gi|27502423 CD46 antigen, complement regulatory protein isoform ... 763 0.0
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 760 0.0
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 744 0.0
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 733 0.0
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 733 0.0
gi|24432108 CD46 antigen, complement regulatory protein isoform ... 728 0.0
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 712 0.0
gi|27502427 CD46 antigen, complement regulatory protein isoform ... 701 0.0
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 685 0.0
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 669 0.0
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 195 5e-50
gi|4502503 complement component 4 binding protein, alpha chain p... 167 1e-41
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 159 4e-39
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 159 4e-39
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 143 3e-34
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 137 1e-32
gi|148886654 polydom [Homo sapiens] 125 6e-29
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 110 3e-24
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 110 3e-24
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 110 3e-24
gi|153266841 apolipoprotein H precursor [Homo sapiens] 108 6e-24
gi|168693643 decay accelerating factor for complement isoform 2 ... 107 2e-23
gi|10835143 decay accelerating factor for complement isoform 1 p... 107 2e-23
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 103 3e-22
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 101 1e-21
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 101 1e-21
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 805 bits (2078), Expect = 0.0
Identities = 378/378 (100%), Positives = 378/378 (100%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
Query: 361 KGTYLTDETHREVKFTSL 378
KGTYLTDETHREVKFTSL
Sbjct: 361 KGTYLTDETHREVKFTSL 378
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 795 bits (2053), Expect = 0.0
Identities = 378/392 (96%), Positives = 378/392 (96%), Gaps = 14/392 (3%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
Query: 301 VSTSSTTKSPASSAS--------------GYPKPEEGILDSLDVWVIAVIVIAIVVGVAV 346
VSTSSTTKSPASSAS GYPKPEEGILDSLDVWVIAVIVIAIVVGVAV
Sbjct: 301 VSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAV 360
Query: 347 ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL 378
ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL
Sbjct: 361 ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL 392
>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
precursor [Homo sapiens]
Length = 385
Score = 773 bits (1995), Expect = 0.0
Identities = 362/362 (100%), Positives = 362/362 (100%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
Query: 361 KG 362
KG
Sbjct: 361 KG 362
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 764 bits (1974), Expect = 0.0
Identities = 363/378 (96%), Positives = 363/378 (96%), Gaps = 15/378 (3%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 286 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 345
Query: 361 KGTYLTDETHREVKFTSL 378
KGTYLTDETHREVKFTSL
Sbjct: 346 KGTYLTDETHREVKFTSL 363
>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
precursor [Homo sapiens]
Length = 399
Score = 763 bits (1970), Expect = 0.0
Identities = 362/376 (96%), Positives = 362/376 (96%), Gaps = 14/376 (3%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
Query: 301 VSTSSTTKSPASSAS--------------GYPKPEEGILDSLDVWVIAVIVIAIVVGVAV 346
VSTSSTTKSPASSAS GYPKPEEGILDSLDVWVIAVIVIAIVVGVAV
Sbjct: 301 VSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAV 360
Query: 347 ICVVPYRYLQRRKKKG 362
ICVVPYRYLQRRKKKG
Sbjct: 361 ICVVPYRYLQRRKKKG 376
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 760 bits (1963), Expect = 0.0
Identities = 360/378 (95%), Positives = 362/378 (95%), Gaps = 1/378 (0%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV S+TK PA S S
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
T K P S+ GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 301 -GPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 359
Query: 361 KGTYLTDETHREVKFTSL 378
KGTYLTDETHREVKFTSL
Sbjct: 360 KGTYLTDETHREVKFTSL 377
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 744 bits (1921), Expect = 0.0
Identities = 353/378 (93%), Positives = 354/378 (93%), Gaps = 16/378 (4%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK P
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP----------- 289
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
T K P S+ GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 290 -----TYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 344
Query: 361 KGTYLTDETHREVKFTSL 378
KGTYLTDETHREVKFTSL
Sbjct: 345 KGTYLTDETHREVKFTSL 362
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 733 bits (1892), Expect = 0.0
Identities = 348/378 (92%), Positives = 348/378 (92%), Gaps = 30/378 (7%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 286 ---------------GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 330
Query: 361 KGTYLTDETHREVKFTSL 378
KGTYLTDETHREVKFTSL
Sbjct: 331 KGTYLTDETHREVKFTSL 348
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 733 bits (1891), Expect = 0.0
Identities = 347/362 (95%), Positives = 347/362 (95%), Gaps = 15/362 (4%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 286 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 345
Query: 361 KG 362
KG
Sbjct: 346 KG 347
>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
precursor [Homo sapiens]
Length = 384
Score = 728 bits (1880), Expect = 0.0
Identities = 344/362 (95%), Positives = 346/362 (95%), Gaps = 1/362 (0%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV S+TK PA S S
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
T K P S+ GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 301 -GPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 359
Query: 361 KG 362
KG
Sbjct: 360 KG 361
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 712 bits (1838), Expect = 0.0
Identities = 337/362 (93%), Positives = 338/362 (93%), Gaps = 16/362 (4%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK P
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP----------- 289
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
T K P S+ GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 290 -----TYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 344
Query: 361 KG 362
KG
Sbjct: 345 KG 346
>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
precursor [Homo sapiens]
Length = 355
Score = 701 bits (1809), Expect = 0.0
Identities = 332/362 (91%), Positives = 332/362 (91%), Gaps = 30/362 (8%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK--------------- 285
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 360
GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK
Sbjct: 286 ---------------GYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKK 330
Query: 361 KG 362
KG
Sbjct: 331 KG 332
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 685 bits (1767), Expect = 0.0
Identities = 322/340 (94%), Positives = 324/340 (95%), Gaps = 1/340 (0%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV S+TK PA S S
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSAS 300
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAI 340
T K P S+ GYPKPEEGILDSLDVWVIAVIVIAI
Sbjct: 301 -GPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAI 339
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 669 bits (1725), Expect = 0.0
Identities = 315/340 (92%), Positives = 316/340 (92%), Gaps = 16/340 (4%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV 60
Query: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG 120
Query: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
Sbjct: 121 YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV 180
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
Sbjct: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
Query: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS 300
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK P
Sbjct: 241 GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP----------- 289
Query: 301 VSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAI 340
T K P S+ GYPKPEEGILDSLDVWVIAVIVIAI
Sbjct: 290 -----TYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAI 324
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 195 bits (496), Expect = 5e-50
Identities = 116/310 (37%), Positives = 155/310 (50%), Gaps = 16/310 (5%)
Query: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
Query: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
Query: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Query: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
Query: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTK 293
ENG +S F V F C GF + G + C + + W+P +P C +V P
Sbjct: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP---- 291
Query: 294 PPALSHSVST 303
PP + H+ T
Sbjct: 292 PPDVLHAERT 301
Score = 105 bits (262), Expect = 7e-23
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
Query: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
Query: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
Score = 99.4 bits (246), Expect = 5e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
Query: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
Query: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
Query: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
F L G TI S N W P P+C
Sbjct: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
Score = 80.1 bits (196), Expect = 3e-15
Identities = 70/265 (26%), Positives = 103/265 (38%), Gaps = 30/265 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
Query: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
Query: 262 LDGSDTIVC---DSNSTWDPPVPKC 283
L GS C S W+ VP C
Sbjct: 384 LKGSSASYCVLAGMESLWNSSVPVC 408
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 167 bits (424), Expect = 1e-41
Identities = 113/333 (33%), Positives = 162/333 (48%), Gaps = 39/333 (11%)
Query: 14 WRFPGLLLAAMVL---LLYSFSDACEEPPT--FEAMELIGKPKPYYEIGERVDYKCKKGY 68
W+ +L M L LL + C PPT F A I + ++ G + Y C GY
Sbjct: 26 WKVSDPILFQMTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGY 85
Query: 69 FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICN 128
T T C+ + W V + C + C + + NGQ V FG Q+ F C+
Sbjct: 86 VRSHSTQTLT-CNSDGEW--VYNTFCIYKRCRHPGELRNGQ-VEIKTDLSFGSQIEFSCS 141
Query: 129 EGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT 188
EG++LIG CE++ WS P CE V C PPP I+NG+H+ E + Y +VT
Sbjct: 142 EGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVT 200
Query: 189 YSCDPAPGPDPFSLIGESTIYCGDNS----VWSRAAPECKVVKCRFPVVENGKQISGFGK 244
YSCDP FSL+G ++I C + VW + P C+ + CR P V +G+ +SGFG
Sbjct: 201 YSCDPR-----FSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255
Query: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTS 304
+ YK T++F+C KGF L GS I CD++S W+P P C P S P + H
Sbjct: 256 IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC---EPNSCINLPDIPH----- 307
Query: 305 STTKSPASSASGYPKPEEGILDSLDVWVIAVIV 337
+S YP+P + DV+V+ ++
Sbjct: 308 -------ASWETYPRPTKE-----DVYVVGTVL 328
Score = 99.8 bits (247), Expect = 4e-21
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 29/238 (12%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAV-- 111
Y +G + Y+C GY T IC +N W P C CP LN +
Sbjct: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQ--GCEALCCP--EPKLNNGEITQ 377
Query: 112 -----PANG-TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
PAN Y +G ++ F C+E C+ G+ WS + P C + C P
Sbjct: 378 HRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGT---WSPRTPSCGDI-CNFP 429
Query: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
PKI +G + S F + + + Y CD + L+G++ + C S WS AP+CK
Sbjct: 430 PKIAHGHYKQSSSYSF-FKEEIIYECDKG-----YILVGQAKLSCS-YSHWSAPAPQCKA 482
Query: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
+ CR P + NG+ +S ++ V +CD G+ + G +I C N TW P VPKC
Sbjct: 483 L-CRKPELVNGR-LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
Score = 55.1 bits (131), Expect = 1e-07
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Y G+ + + C + + IC + TW P + + C + +G +
Sbjct: 389 YFYGDEISFSCHETSRF------SAICQGDGTWSPRTPSC--GDICNFPPKIAHGHYKQS 440
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
+ F ++ + C++GY L+G+ L C S + WS P C K LC P ++ NG+
Sbjct: 441 SSYSFFKEEIIYECDKGYILVGQAKLSC----SYSHWSAPAPQC-KALCRKP-ELVNGRL 494
Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
+ + + E + VT CD G ++G +I C N W P+C+
Sbjct: 495 SVDKDQYVEP-ENVTIQCDSGYG-----VVGPQSITCSGNRTWYPEVPKCE 539
>gi|86793109 complement receptor 1 isoform S precursor [Homo
sapiens]
Length = 2489
Score = 159 bits (402), Expect = 4e-39
Identities = 99/294 (33%), Positives = 138/294 (46%), Gaps = 17/294 (5%)
Query: 18 GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75
G LLA +VLL + C P + + IG ++Y+C+ GY P
Sbjct: 25 GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
Query: 76 THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135
IC +N W D C R++C DP+NG G +FG Q+ + C +GY LIG
Sbjct: 82 FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
Query: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194
C + G IW + PIC+++ C PP I NG + E F Y VTY C+P +
Sbjct: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
Query: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249
G F L+GE +IYC N +WS AP+C + KC P VENG +S F
Sbjct: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
Query: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303
V F C GF + G + C + + W+P +P C +V P PP + H+ T
Sbjct: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP----PPDVLHAERT 309
Score = 154 bits (389), Expect = 1e-37
Identities = 90/258 (34%), Positives = 120/258 (46%), Gaps = 15/258 (5%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+ +G ++Y+C+ GYF C N W V D+ C R++C +P NG V
Sbjct: 1866 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1920
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
N +FG +++ CNEG+ LIG C + G+ W K PICE + C PPP I NG
Sbjct: 1921 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
Query: 174 TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227
+ F VTY C P G F L+GE +IYC VWS P C K
Sbjct: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 2040
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287
C P VEN ++ G F + F C GF + GS T+ C +N W P +P C +V
Sbjct: 2041 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 2100
Query: 288 PPSSTKPPALSHSVSTSS 305
P PP + H T S
Sbjct: 2101 QP----PPEILHGEHTLS 2114
Score = 151 bits (382), Expect = 8e-37
Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+ IG + Y+C+ Y+ P T C N W D C R++C DP+NG V
Sbjct: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
+ G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG
Sbjct: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
Query: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
+ E F Y VTY C+P + G F L+GE +IYC N +WS AP+C + K
Sbjct: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287
C P VENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
Query: 288 PPSSTKPPALSHSVST 303
P PP + H+ T
Sbjct: 748 QP----PPDVLHAERT 759
Score = 151 bits (382), Expect = 8e-37
Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+ IG + Y+C+ Y+ P T C N W D C R++C DP+NG V
Sbjct: 963 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
+ G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG
Sbjct: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 1077
Query: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
+ E F Y VTY C+P + G F L+GE +IYC N +WS AP+C + K
Sbjct: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287
C P VENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
Query: 288 PPSSTKPPALSHSVST 303
P PP + H+ T
Sbjct: 1198 QP----PPDVLHAERT 1209
Score = 149 bits (377), Expect = 3e-36
Identities = 90/258 (34%), Positives = 125/258 (48%), Gaps = 15/258 (5%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+ IG + Y+C+ Y+ P T C N W D C R++C DP+NG V
Sbjct: 1413 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1467
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
+ G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG
Sbjct: 1468 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1527
Query: 174 TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
+ E F Y VTY C+ + G F L+GE +IYC N +WS AP+C + K
Sbjct: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287
C P VENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647
Query: 288 PPSSTKPPALSHSVSTSS 305
P PP + H T S
Sbjct: 1648 QP----PPEILHGEHTPS 1661
Score = 130 bits (327), Expect = 2e-30
Identities = 84/265 (31%), Positives = 121/265 (45%), Gaps = 14/265 (5%)
Query: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
L S S C+ PP E + K + G+ V Y C+ GY A C W
Sbjct: 1190 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 1247
Query: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
P + + ++ LNG+ + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
++W+ P+CE++ C PP I NG+HT +EVF + AV Y+CDP P F LIGE
Sbjct: 1306 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
Query: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
STI C N VWS AP C ++ C+ P + + F ++ +EC
Sbjct: 1366 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 1425
Query: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283
+Y +I C N W P C
Sbjct: 1426 EYY-GRPFSITCLDNLVWSSPKDVC 1449
Score = 129 bits (323), Expect = 6e-30
Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)
Query: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
L S S C+ PP E + K + G+ V Y C+ GY A C W
Sbjct: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
Query: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
P + + ++ LNG+ + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
++W+ P+CE++ C PP I NG+HT +EVF + V Y+CDP P F LIGE
Sbjct: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
Query: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
STI C N VWS AP C ++ C+ P + + F ++ +EC
Sbjct: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
Query: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283
+Y +I C N W P C
Sbjct: 526 EYY-GRPFSITCLDNLVWSSPKDVC 549
Score = 129 bits (323), Expect = 6e-30
Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)
Query: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
L S S C+ PP E + K + G+ V Y C+ GY A C W
Sbjct: 740 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
Query: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
P + + ++ LNG+ + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
++W+ P+CE++ C PP I NG+HT +EVF + V Y+CDP P F LIGE
Sbjct: 856 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
Query: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
STI C N VWS AP C ++ C+ P + + F ++ +EC
Sbjct: 916 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
Query: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283
+Y +I C N W P C
Sbjct: 976 EYY-GRPFSITCLDNLVWSSPKDVC 999
Score = 122 bits (306), Expect = 5e-28
Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 14/265 (5%)
Query: 32 SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
S C+ PP E + + G+ V Y C+ Y + H C W P +
Sbjct: 2097 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 2154
Query: 92 DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
+ ++ +G+ + P N + G ++ F+C+EG+ L G +C L G A+W
Sbjct: 2155 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 2212
Query: 151 SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209
+ P+CE++ C PP I NG+HT + Y ++Y+CD P F+LIGES+I
Sbjct: 2213 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 2272
Query: 210 CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
C N VWS AP C++ C P ++NG I G + T+ + CD G+
Sbjct: 2273 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 2332
Query: 262 LDGSDTIVCDSNSTWDPPVPKCLKV 286
L G I C W C +V
Sbjct: 2333 LVGKGFIFCTDQGIWSQLDHYCKEV 2357
Score = 114 bits (286), Expect = 1e-25
Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 21/270 (7%)
Query: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
L S S C+ PP E + + G+ V Y C+ GY + H C W
Sbjct: 1640 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1697
Query: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
P + + ++ +G+ + P N + G ++ F+C+EG+ L G + +C L G
Sbjct: 1698 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205
++W+ P+CE + C PP I NG+HT + Y ++Y+CDP P F+LIGE
Sbjct: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
Query: 206 STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253
STI C N VWS AP C++ C+ FP I+ F +F ++
Sbjct: 1816 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1873
Query: 254 FECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
+EC G Y +I C N W C
Sbjct: 1874 YECRPG-YFGKMFSISCLENLVWSSVEDNC 1902
Score = 110 bits (274), Expect = 3e-24
Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)
Query: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
++G +V + C +G+ A+H + S C + CP LNG+
Sbjct: 2180 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
Query: 115 -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162
G +G ++ + C+ + LIGE + C + +G+ +WS P CE C
Sbjct: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 2298
Query: 163 TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
PPKI+NG + V ++ ++Y CDP + L+G+ I+C D +WS+
Sbjct: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 2353
Query: 223 CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280
CK V C FP+ NG K++ K ++Y V +C+ G+ L+GS C ++ WDPP+
Sbjct: 2354 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
Query: 281 PKC 283
KC
Sbjct: 2413 AKC 2415
Score = 90.5 bits (223), Expect = 2e-18
Identities = 83/314 (26%), Positives = 128/314 (40%), Gaps = 37/314 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
C PPT + I + + G V Y+C G F + P + + D+ W
Sbjct: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
Query: 87 LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
+ C P + NG V N + + F C G+ + G + C+
Sbjct: 1576 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1631
Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
++ W + P C +V C PPP+I +G+HT S + F V YSC+P + L
Sbjct: 1632 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1683
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
G ++++C WS AP C V C + +G+ + F A V F CD+GF
Sbjct: 1684 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1741
Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKS-PASSASGY 317
L GS C S W+ VP C + P+ PPA+ + T + + P Y
Sbjct: 1742 LKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPN---PPAILNGRHTGTPSGDIPYGKEISY 1798
Query: 318 ---PKPEEGILDSL 328
P P+ G+ +L
Sbjct: 1799 TCDPHPDRGMTFNL 1812
Score = 87.8 bits (216), Expect = 1e-17
Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)
Query: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
++G R++Y C G+ I + I N C R C NG + N
Sbjct: 1472 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1531
Query: 115 G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166
+ +G + + CN G + L+GE +YC V IWSG P C PP
Sbjct: 1532 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1591
Query: 167 KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226
++NG +F + V + C P F + G + C + W P C V
Sbjct: 1592 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1646
Query: 227 KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
P + +G+ F V + C+ G+ L G+ ++ C W P P+C
Sbjct: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703
Score = 87.0 bits (214), Expect = 2e-17
Identities = 81/309 (26%), Positives = 123/309 (39%), Gaps = 37/309 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
C PPT + I + + G V Y+C G F + P + + D+ W
Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
Query: 87 LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
+ C P + NG V N + + F C G+ + G + C+
Sbjct: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
++ W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 1182 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 1233
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
G +++ C WS AAP C+V C + NG+ + F A V F CD+GF
Sbjct: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 1291
Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317
L GS C S W+ VP C ++ PS PP + + T + P A Y
Sbjct: 1292 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKAVNY 1348
Query: 318 ---PKPEEG 323
P P+ G
Sbjct: 1349 TCDPHPDRG 1357
Score = 85.5 bits (210), Expect = 7e-17
Identities = 80/309 (25%), Positives = 121/309 (39%), Gaps = 37/309 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
C PPT + I + + G V Y+C G F + P + + D+ W
Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
Query: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282
Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
G +++ C WS AAP C+V C + NG+ + F A V F CD+GF
Sbjct: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391
Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317
L GS C S W+ VP C ++ PS PP + + T + P Y
Sbjct: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKTVNY 448
Query: 318 ---PKPEEG 323
P P+ G
Sbjct: 449 TCDPHPDRG 457
Score = 85.5 bits (210), Expect = 7e-17
Identities = 80/309 (25%), Positives = 122/309 (39%), Gaps = 37/309 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
C PPT + I + + G V Y+C G F + P + + D+ W
Sbjct: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
Query: 87 LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
+ C P + NG V N + + F C G+ + G + C+
Sbjct: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
++ W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
G +++ C WS AAP C+V C + NG+ + F A V F CD+GF
Sbjct: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317
L GS C S W+ VP C ++ PS PP + + T + P Y
Sbjct: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKTVNY 898
Query: 318 ---PKPEEG 323
P P+ G
Sbjct: 899 TCDPHPDRG 907
Score = 85.1 bits (209), Expect = 9e-17
Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)
Query: 34 ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91
+C PP F M I + G V+Y C +G+ I P T + N TW
Sbjct: 1906 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1961
Query: 92 DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144
C +C NG N T + G + + C+ G + L+GE +YC K
Sbjct: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021
Query: 145 GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
V +WS PP C P+++N F + + + C P F ++
Sbjct: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 2076
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263
G T+ C N W P C V P + +G+ F V + C+ + L
Sbjct: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
Query: 264 GSDTIVCDSNSTWDPPVPKC 283
G+ ++ C W P P+C
Sbjct: 2137 GAASLHCTPQGDWSPEAPRC 2156
Score = 73.2 bits (178), Expect = 4e-13
Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)
Query: 38 PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97
PP E L+ + + + E V+++C+ G+ P C + W P +C R
Sbjct: 1590 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1645
Query: 98 TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
C + L+G+ P++ + G ++ + C GY L G L+C +G WS + P
Sbjct: 1646 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1702
Query: 157 CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212
C C ++ +G+ F + V++ CD + F L G S +C G
Sbjct: 1703 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1755
Query: 213 NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265
S+W+ + P C+ + C P + NG+ Y + + CD F L G
Sbjct: 1756 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1815
Query: 266 DTIVCDS----NSTWDPPVPKC 283
TI C S N W P P+C
Sbjct: 1816 STIRCTSDPHGNGVWSSPAPRC 1837
Score = 71.6 bits (174), Expect = 1e-12
Identities = 77/349 (22%), Positives = 123/349 (35%), Gaps = 93/349 (26%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG------YFYIPPLATHTIC--DRNHT 85
+CE PPT + + + G V Y+C G + + + + D+
Sbjct: 1968 SCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGV 2027
Query: 86 WLP-----VSDDACYRETCPYIRDPLNGQAVPANGTY-EFGYQMHFICNEGYYLIGEEIL 139
W +S + C T P + + + VP N ++ + F C G+ ++G +
Sbjct: 2028 WSSPPPRCISTNKC---TAPEVENAIR---VPGNRSFFTLTEIIRFRCQPGFVMVGSHTV 2081
Query: 140 YCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYS--------- 190
C+ G W K P C +V C PPP+I +G+HT S + F V YS
Sbjct: 2082 QCQTNGR---WGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRG 2137
Query: 191 -----------------------CDPAPGPDP-----------------------FSLIG 204
CD G P F L G
Sbjct: 2138 AASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKG 2197
Query: 205 ESTIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISG------FGKKFYYKATVMF 254
S +C G ++W+ + P C+ + C P + NG+ +GK+ Y
Sbjct: 2198 RSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHP 2257
Query: 255 ECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKVLPPSSTKPPALSH 299
+ F L G +I C S N W P P+C +P + PP + +
Sbjct: 2258 DRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQN 2306
>gi|86793036 complement receptor 1 isoform F precursor [Homo
sapiens]
Length = 2039
Score = 159 bits (402), Expect = 4e-39
Identities = 99/294 (33%), Positives = 138/294 (46%), Gaps = 17/294 (5%)
Query: 18 GLLLAAMVLLLYSFS-DACEEPPTFEAMELIGKPKPY-YEIGERVDYKCKKGYFYIPPLA 75
G LLA +VLL + C P + + IG ++Y+C+ GY P
Sbjct: 25 GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRP--- 81
Query: 76 THTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIG 135
IC +N W D C R++C DP+NG G +FG Q+ + C +GY LIG
Sbjct: 82 FSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIG 139
Query: 136 EEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP-A 194
C + G IW + PIC+++ C PP I NG + E F Y VTY C+P +
Sbjct: 140 SSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGS 199
Query: 195 PGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVVENGKQISGFGKKFYYK 249
G F L+GE +IYC N +WS AP+C + KC P VENG +S F
Sbjct: 200 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN 259
Query: 250 ATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303
V F C GF + G + C + + W+P +P C +V P PP + H+ T
Sbjct: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQP----PPDVLHAERT 309
Score = 154 bits (389), Expect = 1e-37
Identities = 90/258 (34%), Positives = 120/258 (46%), Gaps = 15/258 (5%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+ +G ++Y+C+ GYF C N W V D+ C R++C +P NG V
Sbjct: 1416 FPVGTSLNYECRPGYF---GKMFSISCLENLVWSSVEDN-CRRKSCGPPPEPFNGM-VHI 1470
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
N +FG +++ CNEG+ LIG C + G+ W K PICE + C PPP I NG
Sbjct: 1471 NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1530
Query: 174 TFSEVEVFEYLDAVTYSCDPAP-GPDPFSLIGESTIYCGDN----SVWSRAAPEC-KVVK 227
+ F VTY C P G F L+GE +IYC VWS P C K
Sbjct: 1531 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNK 1590
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287
C P VEN ++ G F + F C GF + GS T+ C +N W P +P C +V
Sbjct: 1591 CTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVC 1650
Query: 288 PPSSTKPPALSHSVSTSS 305
P PP + H T S
Sbjct: 1651 QP----PPEILHGEHTLS 1664
Score = 151 bits (382), Expect = 8e-37
Identities = 90/256 (35%), Positives = 126/256 (49%), Gaps = 15/256 (5%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+ IG + Y+C+ Y+ P T C N W D C R++C DP+NG V
Sbjct: 513 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 567
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
+ G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG
Sbjct: 568 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF 627
Query: 174 TFSEVEVFEYLDAVTYSCDP-APGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
+ E F Y VTY C+P + G F L+GE +IYC N +WS AP+C + K
Sbjct: 628 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 687
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287
C P VENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
Query: 288 PPSSTKPPALSHSVST 303
P PP + H+ T
Sbjct: 748 QP----PPDVLHAERT 759
Score = 149 bits (377), Expect = 3e-36
Identities = 90/258 (34%), Positives = 125/258 (48%), Gaps = 15/258 (5%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+ IG + Y+C+ Y+ P T C N W D C R++C DP+NG V
Sbjct: 963 FPIGTSLKYECRPEYYGRPFSIT---CLDNLVWSSPKD-VCKRKSCKTPPDPVNGM-VHV 1017
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
+ G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG
Sbjct: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF 1077
Query: 174 TFSEVEVFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-K 227
+ E F Y VTY C+ + G F L+GE +IYC N +WS AP+C + K
Sbjct: 1078 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287
C P VENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
Query: 288 PPSSTKPPALSHSVSTSS 305
P PP + H T S
Sbjct: 1198 QP----PPEILHGEHTPS 1211
Score = 130 bits (327), Expect = 2e-30
Identities = 84/265 (31%), Positives = 121/265 (45%), Gaps = 14/265 (5%)
Query: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
L S S C+ PP E + K + G+ V Y C+ GY A C W
Sbjct: 740 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 797
Query: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
P + + ++ LNG+ + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
++W+ P+CE++ C PP I NG+HT +EVF + AV Y+CDP P F LIGE
Sbjct: 856 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 915
Query: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
STI C N VWS AP C ++ C+ P + + F ++ +EC
Sbjct: 916 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 975
Query: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283
+Y +I C N W P C
Sbjct: 976 EYY-GRPFSITCLDNLVWSSPKDVC 999
Score = 129 bits (323), Expect = 6e-30
Identities = 83/265 (31%), Positives = 120/265 (45%), Gaps = 14/265 (5%)
Query: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
L S S C+ PP E + K + G+ V Y C+ GY A C W
Sbjct: 290 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--AASMRCTPQGDWS 347
Query: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
P + + ++ LNG+ + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPG-PDPFSLIGE 205
++W+ P+CE++ C PP I NG+HT +EVF + V Y+CDP P F LIGE
Sbjct: 406 ESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
Query: 206 STIYCGD----NSVWSRAAPECKVV-KCRFP--VVENGKQISGFGKKFYYKATVMFECDK 258
STI C N VWS AP C ++ C+ P + + F ++ +EC
Sbjct: 466 STIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRP 525
Query: 259 GFYLDGSDTIVCDSNSTWDPPVPKC 283
+Y +I C N W P C
Sbjct: 526 EYY-GRPFSITCLDNLVWSSPKDVC 549
Score = 122 bits (306), Expect = 5e-28
Identities = 77/265 (29%), Positives = 118/265 (44%), Gaps = 14/265 (5%)
Query: 32 SDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
S C+ PP E + + G+ V Y C+ Y + H C W P +
Sbjct: 1647 SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH--CTPQGDWSPEAP 1704
Query: 92 DACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
+ ++ +G+ + P N + G ++ F+C+EG+ L G +C L G A+W
Sbjct: 1705 RCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALW 1762
Query: 151 SGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIY 209
+ P+CE++ C PP I NG+HT + Y ++Y+CD P F+LIGES+I
Sbjct: 1763 NSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIR 1822
Query: 210 CGD----NSVWSRAAPECKV---VKCRF-PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
C N VWS AP C++ C P ++NG I G + T+ + CD G+
Sbjct: 1823 CTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYL 1882
Query: 262 LDGSDTIVCDSNSTWDPPVPKCLKV 286
L G I C W C +V
Sbjct: 1883 LVGKGFIFCTDQGIWSQLDHYCKEV 1907
Score = 114 bits (286), Expect = 1e-25
Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 21/270 (7%)
Query: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
L S S C+ PP E + + G+ V Y C+ GY + H C W
Sbjct: 1190 LPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLH--CTPQGDWS 1247
Query: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
P + + ++ +G+ + P N + G ++ F+C+EG+ L G + +C L G
Sbjct: 1248 PEAPRCAVKSCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1305
Query: 147 VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGE 205
++W+ P+CE + C PP I NG+HT + Y ++Y+CDP P F+LIGE
Sbjct: 1306 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1365
Query: 206 STIYCGD----NSVWSRAAPECKVV----KCR----FPVVENGKQISGFGKKFYYKATVM 253
STI C N VWS AP C++ C+ FP I+ F +F ++
Sbjct: 1366 STIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLN 1423
Query: 254 FECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
+EC G Y +I C N W C
Sbjct: 1424 YECRPG-YFGKMFSISCLENLVWSSVEDNC 1452
Score = 110 bits (274), Expect = 3e-24
Identities = 70/243 (28%), Positives = 115/243 (47%), Gaps = 21/243 (8%)
Query: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
++G +V + C +G+ A+H + S C + CP LNG+
Sbjct: 1730 QLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 1789
Query: 115 -GTYEFGYQMHFICNEG------YYLIGEEILYC--ELKGSVAIWSGKPPICE---KVLC 162
G +G ++ + C+ + LIGE + C + +G+ +WS P CE C
Sbjct: 1790 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN-GVWSSPAPRCELSVPAAC 1848
Query: 163 TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
PPKI+NG + V ++ ++Y CDP + L+G+ I+C D +WS+
Sbjct: 1849 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPG-----YLLVGKGFIFCTDQGIWSQLDHY 1903
Query: 223 CKVVKCRFPVVENG--KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280
CK V C FP+ NG K++ K ++Y V +C+ G+ L+GS C ++ WDPP+
Sbjct: 1904 CKEVNCSFPLFMNGISKELE-MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 1962
Query: 281 PKC 283
KC
Sbjct: 1963 AKC 1965
Score = 90.5 bits (223), Expect = 2e-18
Identities = 83/314 (26%), Positives = 128/314 (40%), Gaps = 37/314 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
C PPT + I + + G V Y+C G F + P + + D+ W
Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1125
Query: 87 LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
+ C P + NG V N + + F C G+ + G + C+
Sbjct: 1126 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 1181
Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
++ W + P C +V C PPP+I +G+HT S + F V YSC+P + L
Sbjct: 1182 --ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG-----YDLR 1233
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
G ++++C WS AP C V C + +G+ + F A V F CD+GF
Sbjct: 1234 GAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL--FPLNLQLGAKVSFVCDEGFR 1291
Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKS-PASSASGY 317
L GS C S W+ VP C + P+ PPA+ + T + + P Y
Sbjct: 1292 LKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPN---PPAILNGRHTGTPSGDIPYGKEISY 1348
Query: 318 ---PKPEEGILDSL 328
P P+ G+ +L
Sbjct: 1349 TCDPHPDRGMTFNL 1362
Score = 87.8 bits (216), Expect = 1e-17
Identities = 58/237 (24%), Positives = 90/237 (37%), Gaps = 13/237 (5%)
Query: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
++G R++Y C G+ I + I N C R C NG + N
Sbjct: 1022 QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN 1081
Query: 115 G-TYEFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPP 166
+ +G + + CN G + L+GE +YC V IWSG P C PP
Sbjct: 1082 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1141
Query: 167 KIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226
++NG +F + V + C P F + G + C + W P C V
Sbjct: 1142 NVENGILVSDNRSLFSLNEVVEFRCQPG-----FVMKGPRRVKCQALNKWEPELPSCSRV 1196
Query: 227 KCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
P + +G+ F V + C+ G+ L G+ ++ C W P P+C
Sbjct: 1197 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1253
Score = 87.0 bits (214), Expect = 2e-17
Identities = 81/309 (26%), Positives = 123/309 (39%), Gaps = 37/309 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
C PPT + I + + G V Y+C G F + P + + D+ W
Sbjct: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
Query: 87 LPVSDDACYRETC--PYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCEL 143
+ C P + NG V N + + F C G+ + G + C+
Sbjct: 676 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ- 731
Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
++ W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 732 --ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 783
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
G +++ C WS AAP C+V C + NG+ + F A V F CD+GF
Sbjct: 784 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 841
Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317
L GS C S W+ VP C ++ PS PP + + T + P A Y
Sbjct: 842 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKAVNY 898
Query: 318 ---PKPEEG 323
P P+ G
Sbjct: 899 TCDPHPDRG 907
Score = 85.5 bits (210), Expect = 7e-17
Identities = 80/309 (25%), Positives = 121/309 (39%), Gaps = 37/309 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
C PPT + I + + G V Y+C G F + P + + D+ W
Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
Query: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 226 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 282
Query: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 283 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 333
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
G +++ C WS AAP C+V C + NG+ + F A V F CD+GF
Sbjct: 334 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL--FPVNLQLGAKVDFVCDEGFQ 391
Query: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTK-SPASSASGY 317
L GS C S W+ VP C ++ PS PP + + T + P Y
Sbjct: 392 LKGSSASYCVLAGMESLWNSSVPVCEQIFCPS---PPVIPNGRHTGKPLEVFPFGKTVNY 448
Query: 318 ---PKPEEG 323
P P+ G
Sbjct: 449 TCDPHPDRG 457
Score = 85.1 bits (209), Expect = 9e-17
Identities = 64/260 (24%), Positives = 98/260 (37%), Gaps = 19/260 (7%)
Query: 34 ACEEPPT-FEAMELIGKPKPYYEIGERVDYKCKKGYFYI-PPLATHTICDRNHTWLPVSD 91
+C PP F M I + G V+Y C +G+ I P T + N TW
Sbjct: 1456 SCGPPPEPFNGMVHINTDTQF---GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTW-DKKA 1511
Query: 92 DACYRETCPYIRDPLNGQAVPANGT-YEFGYQMHFICNEG------YYLIGEEILYCELK 144
C +C NG N T + G + + C+ G + L+GE +YC K
Sbjct: 1512 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 1571
Query: 145 GS-VAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
V +WS PP C P+++N F + + + C P F ++
Sbjct: 1572 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPG-----FVMV 1626
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLD 263
G T+ C N W P C V P + +G+ F V + C+ + L
Sbjct: 1627 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 1686
Query: 264 GSDTIVCDSNSTWDPPVPKC 283
G+ ++ C W P P+C
Sbjct: 1687 GAASLHCTPQGDWSPEAPRC 1706
Score = 73.2 bits (178), Expect = 4e-13
Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 30/262 (11%)
Query: 38 PPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRE 97
PP E L+ + + + E V+++C+ G+ P C + W P +C R
Sbjct: 1140 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP--RRVKCQALNKWEP-ELPSCSR- 1195
Query: 98 TCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
C + L+G+ P++ + G ++ + C GY L G L+C +G WS + P
Sbjct: 1196 VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPR 1252
Query: 157 CEKVLCTP-PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC---GD 212
C C ++ +G+ F + V++ CD + F L G S +C G
Sbjct: 1253 CAVKSCDDFLGQLPHGRVLFP--LNLQLGAKVSFVCD-----EGFRLKGSSVSHCVLVGM 1305
Query: 213 NSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD------KGFYLDGS 265
S+W+ + P C+ + C P + NG+ Y + + CD F L G
Sbjct: 1306 RSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGE 1365
Query: 266 DTIVCDS----NSTWDPPVPKC 283
TI C S N W P P+C
Sbjct: 1366 STIRCTSDPHGNGVWSSPAPRC 1387
Score = 71.6 bits (174), Expect = 1e-12
Identities = 77/349 (22%), Positives = 123/349 (35%), Gaps = 93/349 (26%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG------YFYIPPLATHTIC--DRNHT 85
+CE PPT + + + G V Y+C G + + + + D+
Sbjct: 1518 SCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGV 1577
Query: 86 WLP-----VSDDACYRETCPYIRDPLNGQAVPANGTY-EFGYQMHFICNEGYYLIGEEIL 139
W +S + C T P + + + VP N ++ + F C G+ ++G +
Sbjct: 1578 WSSPPPRCISTNKC---TAPEVENAIR---VPGNRSFFTLTEIIRFRCQPGFVMVGSHTV 1631
Query: 140 YCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYS--------- 190
C+ G W K P C +V C PPP+I +G+HT S + F V YS
Sbjct: 1632 QCQTNGR---WGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRG 1687
Query: 191 -----------------------CDPAPGPDP-----------------------FSLIG 204
CD G P F L G
Sbjct: 1688 AASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKG 1747
Query: 205 ESTIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISG------FGKKFYYKATVMF 254
S +C G ++W+ + P C+ + C P + NG+ +GK+ Y
Sbjct: 1748 RSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHP 1807
Query: 255 ECDKGFYLDGSDTIVCDS----NSTWDPPVPKCLKVLPPSSTKPPALSH 299
+ F L G +I C S N W P P+C +P + PP + +
Sbjct: 1808 DRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQN 1856
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 143 bits (360), Expect = 3e-34
Identities = 93/283 (32%), Positives = 130/283 (45%), Gaps = 25/283 (8%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
Query: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
Query: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
Query: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
Query: 265 SDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
S I C +++TWDP +P C K PP L H T T
Sbjct: 639 SSQIRCKADNTWDPEIPVCEK----GCQSPPGLHHGRHTGGNT 677
Score = 134 bits (337), Expect = 1e-31
Identities = 86/269 (31%), Positives = 125/269 (46%), Gaps = 23/269 (8%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
C+ PP G ++ G VDY C GY + + H C + W P S C
Sbjct: 661 CQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIH--CMPSGNWSP-SAPRC 717
Query: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 718 -EETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 770
Query: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 771 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 825
Query: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 826 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 885
Query: 267 TIVCDSNSTWDPPVPKCLKVLPPSSTKPP 295
I C +++TW P VP C+K PP
Sbjct: 886 VIRCHTDNTWVPGVPTCIKKAFIGCPPPP 914
Score = 132 bits (332), Expect = 5e-31
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
Query: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
Query: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
Score = 111 bits (277), Expect = 1e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
C PP + G + G V Y+C +G++ + D + H
Sbjct: 778 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 837
Query: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 838 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 894
Query: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 895 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 949
Query: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 950 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 1009
Query: 266 DTIVCDSNSTWDPPVPKC 283
C S+ W+PP+ C
Sbjct: 1010 PQSQCQSDHQWNPPLAVC 1027
Score = 106 bits (265), Expect = 3e-23
Identities = 74/282 (26%), Positives = 121/282 (42%), Gaps = 32/282 (11%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW---LPVSD 91
C ++ GK PY+ + V +KC G+ ++ C ++TW +PV +
Sbjct: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDPEIPVCE 658
Query: 92 DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151
C + G V + G + + C+ GY L+G + ++C G+ WS
Sbjct: 659 KGCQSPPGLHHGRHTGGNTV----FFVSGMTVDYTCDPGYLLVGNKSIHCMPSGN---WS 711
Query: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
P CE+ ++ + + E+ ++ V SC D + L G + C
Sbjct: 712 PSAPRCEETC-------QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQ 759
Query: 212 D--NSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTI 268
D N +W + P CKV+ C P V+ NGK + F Y V +ECD+GFYL G +
Sbjct: 760 DAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKL 819
Query: 269 VCDSNS----TWDPPVPKCLKVLPPSSTKPPALSHSVSTSST 306
C S+S +W P P+CL+ P + P + H + T
Sbjct: 820 QCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKT 861
Score = 92.4 bits (228), Expect = 6e-19
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
Query: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
Query: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
Query: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
Query: 276 WDPPVPKC 283
W PPVP+C
Sbjct: 459 WTPPVPQC 466
Score = 85.1 bits (209), Expect = 9e-17
Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 799 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 857
Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 858 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 910
Query: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
P NG G +F ++++ CD+G+ L G ++C TW P P C +V
Sbjct: 911 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEV 969
Score = 67.8 bits (164), Expect = 2e-11
Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 16/175 (9%)
Query: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
Query: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
Query: 272 SNSTWDPP-VPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGIL 325
+N+ W P +P C+ V P P + + TS S A S E G L
Sbjct: 134 ANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYL 188
Score = 63.5 bits (153), Expect = 3e-10
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
Query: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
Query: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
Query: 277 DPPVPKC 283
P C
Sbjct: 204 SAVPPTC 210
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 137 bits (346), Expect = 1e-32
Identities = 87/261 (33%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
C+ PP + + ++ G + Y C GY + + C W P
Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQ--CTSEGVWTPPVPQ-- 465
Query: 95 YRETCPYIRDPLNGQAVPANGTYEFGY-QMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
C G+ + ++F ++ C EGY L G +Y E +G++ W +
Sbjct: 466 ----CKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS--VYQECQGTIP-WFME 518
Query: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD 212
+C+++ C PPP I NG HT S +E F Y VTY+C+P P FSLIGESTI C
Sbjct: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578
Query: 213 NS----VWSRAAPECKV----VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDG 264
N WS AP CK+ V+C + NG +ISG ++Y TV F+C GF L G
Sbjct: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
Query: 265 SDTIVCDSNSTWDPPVPKCLK 285
S I C +++TWDP +P C K
Sbjct: 639 SSQIRCKADNTWDPEIPVCEK 659
Score = 132 bits (332), Expect = 5e-31
Identities = 80/238 (33%), Positives = 114/238 (47%), Gaps = 14/238 (5%)
Query: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
G V Y C+ GY + + + + +P + C C + NG+ V
Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT---CEEARCKSLGRFPNGK-VKEPPI 231
Query: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
G +F C+EGY L G C + G W+ K P+CE++ C PP I NG+H +
Sbjct: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
Query: 177 EVEVFEYLDAVTYSCDPAPGPDP-FSLIGESTIYCGDNS----VWSRAAPECKV----VK 227
+ Y VTY+CDP P F LIGEST+ C +S WS AP C++ V+
Sbjct: 291 SLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQ 350
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
C P + G+ +SG ++ Y TV+F C GF L GS I C++ TW+P P C K
Sbjct: 351 CPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK 408
Score = 131 bits (329), Expect = 1e-30
Identities = 83/269 (30%), Positives = 127/269 (47%), Gaps = 23/269 (8%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
C ++ GK PY+ + V +KC G+ ++ C ++TW P C
Sbjct: 602 CSHVHIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKG--SSQIRCKADNTWDP-EIPVC 657
Query: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
+ETC ++R L Q +PA E ++ C +GY L G C+ IW K
Sbjct: 658 EKETCQHVRQSL--QELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQ-DAENGIWFKKI 711
Query: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
P+C+ + C PPP I NGKHT E F Y + V+Y CD F L+GE + C +S
Sbjct: 712 PLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG-----FYLLGEKKLQCRSDS 766
Query: 215 ----VWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
WS +P+C V +C P V++G +++ + + V +C+ GF ++GS
Sbjct: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
Query: 267 TIVCDSNSTWDPPVPKCLKVLPPSSTKPP 295
I C +++TW P VP C+K PP
Sbjct: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPP 855
Score = 111 bits (277), Expect = 1e-24
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 17/258 (6%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICD-RNHTWLPVSDDA 93
C PP + G + G V Y+C +G++ + D + H
Sbjct: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
Query: 94 CYRET----CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
C R CP + + Y ++ CN G+ + G ++ C +
Sbjct: 779 CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT--- 835
Query: 150 WSGKPPICEK---VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGES 206
W P C K + C PPPK NG HT + F ++ YSCD + L+GE+
Sbjct: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQG-----YLLVGEA 890
Query: 207 TIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY-YKATVMFECDKGFYLDGS 265
+ C WS+ AP CK V C P +G Q +K Y Y A V EC+ G+ L+GS
Sbjct: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 950
Query: 266 DTIVCDSNSTWDPPVPKC 283
C S+ W+PP+ C
Sbjct: 951 PQSQCQSDHQWNPPLAVC 968
Score = 93.2 bits (230), Expect = 3e-19
Identities = 59/208 (28%), Positives = 94/208 (45%), Gaps = 25/208 (12%)
Query: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPP 165
++G+ P Y + + F C G+ L G + C+ + W + P+CEK C
Sbjct: 613 ISGKEAP----YFYNDTVTFKCYSGFTLKGSSQIRCKADNT---WDPEIPVCEKETC--- 662
Query: 166 PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD--NSVWSRAAPEC 223
++ + + E+ ++ V SC D + L G + C D N +W + P C
Sbjct: 663 ---QHVRQSLQELPAGSRVELVNTSCQ-----DGYQLTGHAYQMCQDAENGIWFKKIPLC 714
Query: 224 KVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDP 278
KV+ C P V+ NGK + F Y V +ECD+GFYL G + C S+S +W
Sbjct: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774
Query: 279 PVPKCLKVLPPSSTKPPALSHSVSTSST 306
P P+CL+ P + P + H + T
Sbjct: 775 PSPQCLRSPPVTRCPNPEVKHGYKLNKT 802
Score = 92.4 bits (228), Expect = 6e-19
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 21/248 (8%)
Query: 49 KPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLN 107
K P +G ++ C +GY PP + I + W + C CP LN
Sbjct: 227 KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMP--VCEEIFCPSPPPILN 284
Query: 108 GQAVPAN-GTYEFGYQMHFICN----EG--YYLIGEEILYCELKGS-VAIWSGKPPICE- 158
G+ + + +G + + C+ EG + LIGE L C + WSG P CE
Sbjct: 285 GRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCEL 344
Query: 159 ---KVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
V C P P+I G+ + + + Y D V ++C F+L G I C
Sbjct: 345 STSAVQC-PHPQILRGRMVSGQKDRYTYNDTVIFACMFG-----FTLKGSKQIRCNAQGT 398
Query: 216 WSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNST 275
W +AP C+ P + NG++ +F ++ + C+ G+ L G ++I C S
Sbjct: 399 WEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGV 458
Query: 276 WDPPVPKC 283
W PPVP+C
Sbjct: 459 WTPPVPQC 466
Score = 85.1 bits (209), Expect = 9e-17
Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 119 FGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEK---VLCTPPPKIKNGKH 173
+G ++ + C++G+YL+GE+ L C + KG + WSG P C + V P P++K+G
Sbjct: 740 YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQCLRSPPVTRCPNPEVKHGYK 798
Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF--- 230
+ + D V C+P F + G I C ++ W P C +K F
Sbjct: 799 LNKTHSAYSHNDIVYVDCNPG-----FIMNGSRVIRCHTDNTWVPGVPTC--IKKAFIGC 851
Query: 231 ---PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
P NG G +F ++++ CD+G+ L G ++C TW P P C +V
Sbjct: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEV 910
Score = 67.8 bits (164), Expect = 2e-11
Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 16/175 (9%)
Query: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD----NSV 215
+ C PP I NG+ ++ + + YSC F LIGE ++ C +
Sbjct: 21 ISCGSPPPILNGRISYYSTPI-AVGTVIRYSCSGT-----FRLIGEKSLLCITKDKVDGT 74
Query: 216 WSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
W + AP+C K C P+V G +I G + + +V F C F ++G+ ++ C
Sbjct: 75 WDKPAPKCEYFNKYSSCPEPIVPGGYKIRG-STPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
Query: 272 SNSTWDPP-VPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGIL 325
+N+ W P +P C+ V P P + + TS S A S E G L
Sbjct: 134 ANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYL 188
Score = 63.5 bits (153), Expect = 3e-10
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%)
Query: 106 LNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPICE---KVL 161
LNG+ + G + + C+ + LIGE+ L C K V W P CE K
Sbjct: 30 LNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYS 89
Query: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS-RAA 220
P P + G + + + D+VT++C FS+ G +++C N++W
Sbjct: 90 SCPEPIVPGG-YKIRGSTPYRHGDSVTFAC-----KTNFSMNGNKSVWCQANNMWGPTRL 143
Query: 221 PECKVV---KC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTW 276
P C V +C P++ NG S +V + C+ G+ L G I C S+ W
Sbjct: 144 PTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKW 203
Query: 277 DPPVPKC 283
P C
Sbjct: 204 SAVPPTC 210
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 125 bits (314), Expect = 6e-29
Identities = 82/253 (32%), Positives = 118/253 (46%), Gaps = 33/253 (13%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ-AVP 112
Y +G V + C++GY + T C + W PY + G+ A+P
Sbjct: 1805 YTVGAEVTFSCQEGYQLMG--VTKITCLESGEW---------NHLIPYCKAVSCGKPAIP 1853
Query: 113 ANGTYE-----FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
NG E FG ++ + CN+GY L G++ C S WS PP+CE V C+ P
Sbjct: 1854 ENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSS---WSHSPPVCEPVKCSSPEN 1910
Query: 168 IKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVK 227
I NGK+ S + YL +YSCD +SL G S I C + +W RA P C +V
Sbjct: 1911 INNGKYILSGL---TYLSTASYSCDTG-----YSLQGPSIIECTASGIWDRAPPACHLVF 1962
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVL 287
C P I+ G F ++ TV + C +G+ L G DTI C ++ W +CL V
Sbjct: 1963 CGEPPAIKDAVIT--GNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAV- 2019
Query: 288 PPSSTKPPALSHS 300
S +PP + H+
Sbjct: 2020 --SCDEPPIVDHA 2030
Score = 108 bits (269), Expect = 1e-23
Identities = 78/277 (28%), Positives = 118/277 (42%), Gaps = 24/277 (8%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA- 93
CE+PP+ L K + G V +KC +G+ + + C R W P
Sbjct: 2083 CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGF--VLNTSAKIECMRGGQWNPSPMSIQ 2140
Query: 94 CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
C C +NG A +N Y FG + + CN+G+Y+ GE+ CE G WS
Sbjct: 2141 CIPVRCGEPPSIMNGYASGSN--YSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WSSP 2195
Query: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
P C V C PPK++NG + +FE V Y C+P + +G C N
Sbjct: 2196 IPTCHPVSCGEPPKVENGFLEHTTGRIFE--SEVRYQCNPG-----YKSVGSPVFVCQAN 2248
Query: 214 SVWSRAAP-ECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
W +P C + C + P ++NG G+ F + V F C++G+ L G + C
Sbjct: 2249 RHWHSESPLMCVPLDCGKPPPIQNGFM---KGENFEVGSKVQFFCNEGYELVGDSSWTCQ 2305
Query: 272 SNSTWDPPV-PKCLKVLPPSSTKPPALSHSVSTSSTT 307
+ W+ PKC +P +PP L + + T
Sbjct: 2306 KSGKWNKKSNPKC---MPAKCPEPPLLENQLVLKELT 2339
Score = 103 bits (258), Expect = 2e-22
Identities = 80/293 (27%), Positives = 122/293 (41%), Gaps = 51/293 (17%)
Query: 16 FPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYF------ 69
FPG +A + S PT ++ G P P+ + G+ K +GYF
Sbjct: 2583 FPGFQVAGHAMQTCEESGWSSSIPTCMPIDC-GLP-PHIDFGDCTKLKDDQGYFEQEDDM 2640
Query: 70 ----YIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA--NGTYEFGYQM 123
Y+ P + + TW N + PA + + +G +
Sbjct: 2641 MEVPYVTPHPPYHLGAVAKTWE-------------------NTKESPATHSSNFLYGTMV 2681
Query: 124 HFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEY 183
+ CN GY L+G +L C+ G+ W+G P C + C P +NG F+E +
Sbjct: 2682 SYTCNPGYELLGNPVLICQEDGT---WNGSAPSCISIECDLPTAPENGFLRFTETSMGS- 2737
Query: 184 LDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP-VVENGKQISGF 242
AV YSC P L G C +N WS A+P C+ + C+ P V NG S
Sbjct: 2738 --AVQYSCKPG-----HILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNG---SIK 2787
Query: 243 GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPP 295
G + Y +T+ +ECD G+ L+G++ C + WD P C +P + PP
Sbjct: 2788 GSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPIC---IPVDCSSPP 2837
Score = 102 bits (255), Expect = 4e-22
Identities = 79/267 (29%), Positives = 116/267 (43%), Gaps = 27/267 (10%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
+C EPP E L +E V Y+C GY + + +C N W S
Sbjct: 2203 SCGEPPKVENGFLEHTTGRIFE--SEVRYQCNPGYKSVG--SPVFVCQANRHWHSESPLM 2258
Query: 94 CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
C C NG N +E G ++ F CNEGY L+G+ C+ G W+ K
Sbjct: 2259 CVPLDCGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQKSGK---WNKK 2313
Query: 154 P-PICEKVLCTPPPKIKNG---KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIY 209
P C C PP ++N K +EV V VT+SC + L G S +
Sbjct: 2314 SNPKCMPAKCPEPPLLENQLVLKELTTEVGV------VTFSCK-----EGHVLQGPSVLK 2362
Query: 210 CGDNSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTI 268
C + W+ + P CK+V C P ++ G I ++ +TV + C GF+L G+ T
Sbjct: 2363 CLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPS--SALHFGSTVKYSCVGGFFLRGNSTT 2420
Query: 269 VCDSNSTWDPPVPKCLKVLPPSSTKPP 295
+C + TW P+P+C+ V P + P
Sbjct: 2421 LCQPDGTWSSPLPECVPVECPQPEEIP 2447
Score = 102 bits (253), Expect = 7e-22
Identities = 73/245 (29%), Positives = 108/245 (44%), Gaps = 23/245 (9%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLNGQAVP 112
+ + +V C +GY + ++C + TW P SD++C +C P +G V
Sbjct: 3197 FSVNRQVSVSCAEGYTFEG--VNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVG 3254
Query: 113 ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
+ T+E + + C GY L G C+ WSG IC++ C P + NGK
Sbjct: 3255 SKYTFES--TIIYQCEPGYELEGNRERVCQENRQ---WSGGVAICKETRCETPLEFLNGK 3309
Query: 173 HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP- 231
+++E V YSC+ +SL G S +C +N WS P CK C P
Sbjct: 3310 ---ADIENRTTGPNVVYSCNRG-----YSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPF 3361
Query: 232 VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSS 291
V+ +S K+FY V +C +GF L G I C+ + TW KC K+ S
Sbjct: 3362 VIPENALLSE--KEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKI----S 3415
Query: 292 TKPPA 296
PPA
Sbjct: 3416 CGPPA 3420
Score = 101 bits (252), Expect = 1e-21
Identities = 74/251 (29%), Positives = 105/251 (41%), Gaps = 24/251 (9%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
C EPP E ++ + E+G V + CK+G+ P C + W S C
Sbjct: 2323 CPEPPLLENQLVLKELTT--EVGV-VTFSCKEGHVLQGPSVLK--CLPSQQWND-SFPVC 2376
Query: 95 YRETCPYIRDPLNGQAVPA-NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
C PL VP + FG + + C G++L G C+ G+ WS
Sbjct: 2377 KIVLCT--PPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGT---WSSP 2431
Query: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
P C V C P +I NG +V+ YL Y+C P F L+G +T CG+N
Sbjct: 2432 LPECVPVECPQPEEIPNG---IIDVQGLAYLSTALYTCKPG-----FELVGNTTTLCGEN 2483
Query: 214 SVWSRAAPECKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
W P CK ++C P + NGK +Y TV + C++GF L+G + C
Sbjct: 2484 GHWLGGKPTCKAIECLKPKEILNGKFSY---TDLHYGQTVTYSCNRGFRLEGPSALTCLE 2540
Query: 273 NSTWDPPVPKC 283
WD P C
Sbjct: 2541 TGDWDVDAPSC 2551
Score = 97.8 bits (242), Expect = 1e-20
Identities = 71/253 (28%), Positives = 103/253 (40%), Gaps = 35/253 (13%)
Query: 57 GERVDYKCKKGYFYI--PPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
G V Y C GY + P L IC + TW S +C C P N
Sbjct: 2678 GTMVSYTCNPGYELLGNPVL----ICQEDGTWNG-SAPSCISIECDL-------PTAPEN 2725
Query: 115 GTYEF-----GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
G F G + + C G+ L G ++ C WSG P CE + C P +
Sbjct: 2726 GFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRK---WSGASPRCEAISCKKPNPVM 2782
Query: 170 NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
NG S + YL + Y CDP + L G C D+ W P C V C
Sbjct: 2783 NGSIKGSN---YTYLSTLYYECDPG-----YVLNGTERRTCQDDKNWDEDEPICIPVDCS 2834
Query: 230 FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
P V Q+ G ++ ++ + + C++GF L+G+ + VC +N +W P C +P
Sbjct: 2835 SPPVSANGQVRG--DEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDC---VPV 2889
Query: 290 SSTKPPALSHSVS 302
PP L++ V+
Sbjct: 2890 RCATPPQLANGVT 2902
Score = 97.4 bits (241), Expect = 2e-20
Identities = 84/289 (29%), Positives = 114/289 (39%), Gaps = 60/289 (20%)
Query: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD-----------------------DA 93
G V Y+C GY+ + + C N +W VS D
Sbjct: 1709 GSTVTYQCNNGYYLLGD--SRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDG 1766
Query: 94 CYRETC--PYIRDPLN--------GQAVPANG-----TYEFGYQMHFICNEGYYLIGEEI 138
Y +C PY D N P NG Y G ++ F C EGY L+G
Sbjct: 1767 SYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTK 1826
Query: 139 LYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPD 198
+ C G W+ P C+ V C P +NG E F + VTY C+
Sbjct: 1827 ITCLESGE---WNHLIPYCKAVSCGKPAIPENG---CIEELAFTFGSKVTYRCNKG---- 1876
Query: 199 PFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV-VENGKQI-SGFGKKFYYKATVMFEC 256
++L G+ C NS WS + P C+ VKC P + NGK I SG Y +T + C
Sbjct: 1877 -YTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG----LTYLSTASYSC 1931
Query: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSS 305
D G+ L G I C ++ WD P C V +PPA+ +V T +
Sbjct: 1932 DTGYSLQGPSIIECTASGIWDRAPPACHLVF---CGEPPAIKDAVITGN 1977
Score = 95.9 bits (237), Expect = 5e-20
Identities = 70/249 (28%), Positives = 103/249 (41%), Gaps = 22/249 (8%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
C PP ++ G Y + ++Y C +G+ A +C N +W + D C
Sbjct: 2833 CSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLLEG--ARSRVCLANGSWSGATPD-C 2886
Query: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
C NG V Y F ++ F C+EGY L G L C+ G+ W +
Sbjct: 2887 VPVRCATPPQLANG--VTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGN---WDAEI 2941
Query: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
P+C+ V C PP + +G F F + + Y C P + L G S+ C N
Sbjct: 2942 PLCKPVNCGPPEDLAHG---FPNGFSFIHGGHIQYQCFPG-----YKLHGNSSRRCLSNG 2993
Query: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS 274
WS ++P C +C PV+E G + G F +C KGF L G I C+++
Sbjct: 2994 SWSGSSPSCLPCRCSTPVIEYG---TVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADG 3050
Query: 275 TWDPPVPKC 283
W P C
Sbjct: 3051 QWSSGFPHC 3059
Score = 93.2 bits (230), Expect = 3e-19
Identities = 72/259 (27%), Positives = 105/259 (40%), Gaps = 26/259 (10%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
C PP I P G V Y C G+F + T+C + TW + C
Sbjct: 2381 CTPPPLISFGVPI--PSSALHFGSTVKYSCVGGFFLRGN--STTLCQPDGTWSSPLPE-C 2435
Query: 95 YRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
CP + NG + G + + C G+ L+G C G W G
Sbjct: 2436 VPVECPQPEEIPNG-IIDVQGLAYLSTAL-YTCKPGFELVGNTTTLCGENGH---WLGGK 2490
Query: 155 PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
P C+ + C P +I NGK +++++ Y VTYSC+ F L G S + C +
Sbjct: 2491 PTCKAIECLKPKEILNGKFSYTDLH---YGQTVTYSCNRG-----FRLEGPSALTCLETG 2542
Query: 215 VWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSN 273
W AP C + C P +ENG G + Y A +++ C GF + G C+
Sbjct: 2543 DWDVDAPSCNAIHCDSPQPIENG---FVEGADYSYGAIIIYSCFPGFQVAGHAMQTCE-E 2598
Query: 274 STWDPPVPKCLKV---LPP 289
S W +P C+ + LPP
Sbjct: 2599 SGWSSSIPTCMPIDCGLPP 2617
Score = 92.4 bits (228), Expect = 6e-19
Identities = 69/245 (28%), Positives = 104/245 (42%), Gaps = 23/245 (9%)
Query: 56 IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANG 115
+G V Y CK G+ + +C N W S C +C +NG +N
Sbjct: 2735 MGSAVQYSCKPGHILAG--SDLRLCLENRKWSGASP-RCEAISCKKPNPVMNGSIKGSNY 2791
Query: 116 TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF 175
TY +++ C+ GY L G E C+ + W PIC V C+ PP NG+
Sbjct: 2792 TYLS--TLYYECDPGYVLNGTERRTCQDDKN---WDEDEPICIPVDCSSPPVSANGQVRG 2846
Query: 176 SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV-VE 234
E + + + Y+C+ + F L G + C N WS A P+C V+C P +
Sbjct: 2847 DE---YTFQKEIEYTCN-----EGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLA 2898
Query: 235 NGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKP 294
NG G + + V F C +G+ L G+ + C S+ WD +P C P + P
Sbjct: 2899 NGVTE---GLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLC---KPVNCGPP 2952
Query: 295 PALSH 299
L+H
Sbjct: 2953 EDLAH 2957
Score = 79.0 bits (193), Expect = 7e-15
Identities = 71/277 (25%), Positives = 104/277 (37%), Gaps = 25/277 (9%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTI-CDRNHTWLPVSDDA 93
C EPP + + G + V Y CK+GY TI C + W SD
Sbjct: 1963 CGEPPAIKDAVITGNN---FTFRNTVTYTCKEGYTLA---GLDTIECLADGKWSR-SDQQ 2015
Query: 94 CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
C +C P+ A P FG + C++GY L L C +G G+
Sbjct: 2016 CLAVSCD--EPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQ 2073
Query: 154 P-PICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD 212
P C C PP + F V++ C + F L + I C
Sbjct: 2074 DMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKC-----MEGFVLNTSAKIECMR 2128
Query: 213 NSVW--SRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
W S + +C V+C P + NG G + + A V + C+KGFY+ G
Sbjct: 2129 GGQWNPSPMSIQCIPVRCGEPPSIMNGY---ASGSNYSFGAMVAYSCNKGFYIKGEKKST 2185
Query: 270 CDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSST 306
C++ W P+P C P S +PP + + +T
Sbjct: 2186 CEATGQWSSPIPTC---HPVSCGEPPKVENGFLEHTT 2219
Score = 77.8 bits (190), Expect = 1e-14
Identities = 55/225 (24%), Positives = 92/225 (40%), Gaps = 54/225 (24%)
Query: 105 PLNGQAVP----ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKV 160
P G +VP A+ + G +++ C+ G+ L+G + YC +G W+ P CE++
Sbjct: 1632 PRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQ---WTQPLPHCERI 1688
Query: 161 LCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAA 220
C PP ++NG H+ + F VTY C+ + + L+G+S ++C DN W+ +
Sbjct: 1689 SCGVPPPLENGFHSADD---FYAGSTVTYQCN-----NGYYLLGDSRMFCTDNGSWNGVS 1740
Query: 221 PECK------------------------VVKCRFPVVENGKQIS---------------G 241
P C + C P +GK +
Sbjct: 1741 PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS 1800
Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
G+ + A V F C +G+ L G I C + W+ +P C V
Sbjct: 1801 SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAV 1845
Score = 74.3 bits (181), Expect = 2e-13
Identities = 70/255 (27%), Positives = 103/255 (40%), Gaps = 25/255 (9%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
+C +P + E ++G Y + Y+C+ GY +C N W
Sbjct: 3240 SCGKPESPEHGFVVGSK---YTFESTIIYQCEPGYELEGN--RERVCQENRQWSG-GVAI 3293
Query: 94 CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
C C + LNG+A N T G + + CN GY L G +C G+ WS
Sbjct: 3294 CKETRCETPLEFLNGKADIENRTT--GPNVVYSCNRGYSLEGPSEAHCTENGT---WSHP 3348
Query: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDA-VTYSCDPAPGPDPFSLIGESTIYCGD 212
P+C+ C P P + SE E Y+D V+ C + F L G I C
Sbjct: 3349 VPLCKPNPC-PVPFVIPENALLSEKEF--YVDQNVSIKCR-----EGFLLQGHGIITCNP 3400
Query: 213 NSVWSRAAPECKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271
+ W++ + +C+ + C P VEN G + Y + + C G+ L+G VC
Sbjct: 3401 DETWTQTSAKCEKISCGPPAHVENA---IARGVHYQYGDMITYSCYSGYMLEGFLRSVCL 3457
Query: 272 SNSTWDPPVPKCLKV 286
N TW P P C V
Sbjct: 3458 ENGTWTSP-PICRAV 3471
Score = 72.4 bits (176), Expect = 6e-13
Identities = 50/161 (31%), Positives = 71/161 (44%), Gaps = 27/161 (16%)
Query: 126 ICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLD 185
+C EGY G+ CEL A+ KPP +NG F + + +
Sbjct: 361 VCREGYRASGQT---CELVHCPAL---KPP-------------ENGY--FIQNTCNNHFN 399
Query: 186 AVT-YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGK 244
A C P F L+G S I C N +WS + C+V C IS +
Sbjct: 400 AACGVRCHPG-----FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTR 454
Query: 245 KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
+ YK T + CD+G+ L+GSD + C NS WD P P+C++
Sbjct: 455 EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVE 495
Score = 70.1 bits (170), Expect = 3e-12
Identities = 50/186 (26%), Positives = 67/186 (36%), Gaps = 23/186 (12%)
Query: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG-----KHTFSEVE 179
+ C GY + G L C KG +WS P+CE + C PP + N HT+
Sbjct: 3088 YSCRSGYVIQGSSDLICTEKG---VWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEV 3144
Query: 180 VFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQI 239
L+ T D T C + W C KC P+ EN I
Sbjct: 3145 KLRCLEGYTMDTDT------------DTFTCQKDGRWFPERISCSPKKC--PLPENITHI 3190
Query: 240 SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSH 299
G F V C +G+ +G + VC + TW+PP P S KP + H
Sbjct: 3191 LVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSD-ESCSPVSCGKPESPEH 3249
Query: 300 SVSTSS 305
S
Sbjct: 3250 GFVVGS 3255
Score = 68.6 bits (166), Expect = 9e-12
Identities = 45/153 (29%), Positives = 68/153 (44%), Gaps = 18/153 (11%)
Query: 144 KGSVAIWS-------GKPPICEK-VLCTPPPKIKNG-KHTFSEVEVFEYLDAVTYSCDPA 194
KG+V W GK I K + C+ P++ H + E + V CDP
Sbjct: 1602 KGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPG 1661
Query: 195 PGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV-VENGKQISGFGKKFYYKATVM 253
F L+G YC + W++ P C+ + C P +ENG + FY +TV
Sbjct: 1662 -----FQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSAD---DFYAGSTVT 1713
Query: 254 FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
++C+ G+YL G + C N +W+ P CL V
Sbjct: 1714 YQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDV 1746
Score = 59.7 bits (143), Expect = 4e-09
Identities = 51/200 (25%), Positives = 75/200 (37%), Gaps = 29/200 (14%)
Query: 90 SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAI 149
S C CP ++ P NG + F C+ G+ L+G I+ C G +
Sbjct: 369 SGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNG---L 425
Query: 150 WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVT--YSCDPAPGPDPFSLIGEST 207
WSG C C P ++ KH E L T +CD + + L G
Sbjct: 426 WSGSESYCRVRTC---PHLRQPKHGHISCSTREMLYKTTCLVACD-----EGYRLEGSDK 477
Query: 208 IYCGDNSVWSRAAPECKVVKC-RFPVVEN--------GKQISGFGKKFYYKATVMFECDK 258
+ C NS W P C C F + ++ GKQ + FG Y C +
Sbjct: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICY------VSCRQ 531
Query: 259 GFYLDG-SDTIVCDSNSTWD 277
GF L G + + C ++ W+
Sbjct: 532 GFILSGVKEMLRCTTSGKWN 551
Score = 30.8 bits (68), Expect = 2.1
Identities = 31/116 (26%), Positives = 42/116 (36%), Gaps = 3/116 (2%)
Query: 190 SCDPAPGPDPFSLIGESTIY-CGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFY 247
SC P P + S G ++ C + + C++V C ENG I +
Sbjct: 339 SCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNN-H 397
Query: 248 YKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVST 303
+ A C GF L GS I+C N W C P +P S ST
Sbjct: 398 FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCST 453
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 110 bits (274), Expect = 3e-24
Identities = 80/251 (31%), Positives = 112/251 (44%), Gaps = 23/251 (9%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Y +G+ V Y C+ GY + C N TW V C TCP NG+
Sbjct: 3149 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP-TCRAVTCPTPPQISNGRLEGT 3207
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
N +++G+ + +IC+ GY L +L C G+ WSG+ P C C P GK
Sbjct: 3208 N--FDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKR 3262
Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC---KVVKCRF 230
E + F Y V++SC+ PF L+G ST C + WS ++P C C
Sbjct: 3263 ---EGKSFIYQSEVSFSCN-----FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN 3314
Query: 231 P-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
P V +G Q + FG F + V F C KG L GS T C + TW P+C +P
Sbjct: 3315 PGVPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC---IPH 3369
Query: 290 SSTKPPALSHS 300
S +P +H+
Sbjct: 3370 SCKQPETPAHA 3380
Score = 103 bits (258), Expect = 2e-22
Identities = 76/248 (30%), Positives = 106/248 (42%), Gaps = 32/248 (12%)
Query: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT--- 116
V Y C +GY P C N TW + C +C DP +PANG
Sbjct: 3097 VIYSCMEGYILSGPSVRQ--CTANGTWSGTLPN-CTIISCG---DP----GIPANGLRYG 3146
Query: 117 --YEFGYQMHFICNEGYY--LIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
Y G + ++C GY L G I C + G+ WSG P C V C PP+I NG+
Sbjct: 3147 DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGR 3203
Query: 173 HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP- 231
E F++ +++Y C P + L + + C N WS P+C C P
Sbjct: 3204 ---LEGTNFDWGFSISYICSPG-----YELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3255
Query: 232 VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSS 291
+ GK+ GK F Y++ V F C+ F L GS T +C ++ TW P C++ S
Sbjct: 3256 IPAQGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSC 3312
Query: 292 TKPPALSH 299
P H
Sbjct: 3313 ENPGVPRH 3320
Score = 102 bits (254), Expect = 6e-22
Identities = 73/257 (28%), Positives = 112/257 (43%), Gaps = 25/257 (9%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
+C E PT IG Y G + C G+ + C + W S+
Sbjct: 2718 SCGELPTPPNGNKIGTQTSY---GSTAIFTCDLGFMLVGSAVRE--CLSSGLWSE-SETR 2771
Query: 94 CYRETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWS 151
C C +NGQ + N +GY+ + + CN G+ LIG + C+ + WS
Sbjct: 2772 CLAGHCGIPELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHN---WS 2824
Query: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
G+ P C V C P G+ + + F + D VT+SC+ + + G + C
Sbjct: 2825 GQLPSCVPVSCGHPGSPIYGRTSGNG---FNFNDVVTFSCNIG-----YLMQGPTKAQCQ 2876
Query: 212 DNSVWSRAAPECKVVKCRFP-VVENGKQISGFGK-KFYYKATVMFECDKGFYLDGSDTIV 269
N WS P CKVV C P + N K+ S F Y V ++C+ G++L GS ++
Sbjct: 2877 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2936
Query: 270 CDSNSTWDPPVPKCLKV 286
C N WD P+P+C+ +
Sbjct: 2937 CQPNGQWDKPLPECIMI 2953
Score = 102 bits (253), Expect = 7e-22
Identities = 66/238 (27%), Positives = 109/238 (45%), Gaps = 17/238 (7%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVS-DDACYRETCPYIRDPL--NGQA 110
Y +G RV Y C GY T +C + TW + C TCP I + +G+
Sbjct: 2608 YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRW 2667
Query: 111 VPANGT-YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
NG+ YE+ ++ F C+ GY+ +G + C G+ + W + P C+ + C P
Sbjct: 2668 RIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS-WRNERPYCQIISCGELPTPP 2726
Query: 170 NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
NG ++ Y ++CD F L+G + C + +WS + C C
Sbjct: 2727 NGNKIGTQT---SYGSTAIFTCDLG-----FMLVGSAVRECLSSGLWSESETRCLAGHCG 2778
Query: 230 FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
P ++ NG+ I G+ + Y+ TV+++C+ GF L GS +C + W +P C+ V
Sbjct: 2779 IPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV 2833
Score = 95.9 bits (237), Expect = 5e-20
Identities = 75/263 (28%), Positives = 104/263 (39%), Gaps = 28/263 (10%)
Query: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD-DACYRETCPYIRDPLNGQAV 111
+YE +V + C GY + P + C N TW ++ C +C + P NG +
Sbjct: 2674 HYEYKTKVVFSCDPGYHGLGPASIE--CLPNGTWSWRNERPYCQIISCGELPTPPNGNKI 2731
Query: 112 PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG 171
+Y G F C+ G+ L+G + C G +WS C C P I NG
Sbjct: 2732 GTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNG 2786
Query: 172 KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP 231
+ E + Y D V Y C+P F LIG S C + WS P C V C P
Sbjct: 2787 QVI---GENYGYRDTVVYQCNPG-----FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP 2838
Query: 232 VVENGKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV--- 286
G I G G F + V F C+ G+ + G C +N W P P C V
Sbjct: 2839 ----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCS 2894
Query: 287 ---LPPSSTKPPALSHSVSTSST 306
+P +S + + H T T
Sbjct: 2895 DPGIPANSKRESKIEHGNFTYGT 2917
Score = 88.2 bits (217), Expect = 1e-17
Identities = 70/235 (29%), Positives = 95/235 (40%), Gaps = 24/235 (10%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTW-LPVSDDACYRETCPYIRDPLNGQAVP 112
+ G V Y C GYF ++ IC N W P+ + C C + P N AV
Sbjct: 2913 FTYGTVVFYDCNPGYFLFG--SSVLICQPNGQWDKPLPE--CIMIDCGHPGVPPN--AVL 2966
Query: 113 ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE---KVLCTPPPKIK 169
+ Y FG +H+ C L+G+ C+L G WSG P C C P
Sbjct: 2967 SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG 3023
Query: 170 NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
+G S F V Y+CD + L G C N W+ PECK V+C
Sbjct: 3024 HGSRQESN---FRTKSTVRYACDTG-----YILHGSEERTCLANGSWTGRQPECKAVQCG 3075
Query: 230 FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
P NGK G F ++V++ C +G+ L G C +N TW +P C
Sbjct: 3076 NPGTTANGKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC 3128
Score = 80.9 bits (198), Expect = 2e-15
Identities = 68/245 (27%), Positives = 97/245 (39%), Gaps = 35/245 (14%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNG--QAV 111
+ + V + C GY P T C N W C C P N ++
Sbjct: 2851 FNFNDVVTFSCNIGYLMQGP--TKAQCQANRQWSH-PPPMCKVVNCSDPGIPANSKRESK 2907
Query: 112 PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC----TPPPK 167
+G + +G + + CN GY+L G +L C+ G W P C + C PP
Sbjct: 2908 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNA 2964
Query: 168 IKNG-KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK-- 224
+ +G K+TF V YSC SL+G+S+ C N WS + P C
Sbjct: 2965 VLSGEKYTFGST--------VHYSCTGKR-----SLLGQSSRTCQLNGHWSGSQPHCSGD 3011
Query: 225 -VVKCRFPVV--ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
C P +Q S F K +TV + CD G+ L GS+ C +N +W P
Sbjct: 3012 ATGTCGDPGTPGHGSRQESNFRTK----STVRYACDTGYILHGSEERTCLANGSWTGRQP 3067
Query: 282 KCLKV 286
+C V
Sbjct: 3068 ECKAV 3072
Score = 70.5 bits (171), Expect = 2e-12
Identities = 80/284 (28%), Positives = 111/284 (39%), Gaps = 47/284 (16%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDA 93
C PP L G ++ G + Y C GY P + T C N TW
Sbjct: 3193 CPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLT---CVGNGTWSGEVPQ- 3245
Query: 94 CYRETCPYIRDPLNGQAVPANGTYE---FGYQ--MHFICNEGYYLIGEEILYCELKGSVA 148
C + C DP +PA G E F YQ + F CN + L+G C+ G+
Sbjct: 3246 CLPKFCG---DP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT-- 3296
Query: 149 IWSGKPPIC---EKVLCTPP--PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
WSG P C + C P P+ + +TF F+ V + C L
Sbjct: 3297 -WSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKG-----HLLQ 3346
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYL- 262
G +T C + WS PEC C+ P + G + T+++ C GF+L
Sbjct: 3347 GSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH-GYTLIYTCQPGFFLA 3405
Query: 263 DGSDTIVCDSNSTWDPPVPKC---LKVL-----PPSSTKPPALS 298
G++ VC S++TW VP C K+L P T P LS
Sbjct: 3406 GGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLS 3449
Score = 62.8 bits (151), Expect = 5e-10
Identities = 49/188 (26%), Positives = 76/188 (40%), Gaps = 21/188 (11%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSGKPPIC 157
C P +G + G + + + C+ G+ L+G+ C W P C
Sbjct: 2529 CSTPESPPHGYIISQTGG-QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587
Query: 158 EKVLCTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGE--STIYCGDN 213
+ + C P NG + +YL VTY C+ D + L + +T C +
Sbjct: 2588 QAISCGIPKAPTNGG-----ILTTDYLVGTRVTYFCN-----DGYRLSSKELTTAVCQSD 2637
Query: 214 SVWSR--AAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTI 268
WS P C VV C ++E+G+ G + YK V+F CD G++ G +I
Sbjct: 2638 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI 2697
Query: 269 VCDSNSTW 276
C N TW
Sbjct: 2698 ECLPNGTW 2705
Score = 51.2 bits (121), Expect = 1e-06
Identities = 67/285 (23%), Positives = 104/285 (36%), Gaps = 69/285 (24%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPIC 157
CP +P NG+ + ++ + G + F C+E Y L G + + C+ V A WS P+C
Sbjct: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 158 EKVLCTPPPKIKNGKHTF--------SEVEVFEYLDAVTYSCDPAPGPDPFSL-IGESTI 208
+ C + +G T S + + AV + + F L IG T+
Sbjct: 504 KVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTL 563
Query: 209 YCGD---------------------------NSVWSRAAPECKVVKCRFPVV-------- 233
GD + +W + V F V
Sbjct: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623
Query: 234 --ENGKQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
+ G + G G F + + FEC GF L G +IVC N+ W +P C+
Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF---- 679
Query: 290 SSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLD-VWVI 333
P LS+ + T SP YP EG ++L+ +W I
Sbjct: 680 -----PCLSNFTAPMGTVLSP-----DYP---EGYGNNLNCIWTI 711
Score = 43.5 bits (101), Expect = 3e-04
Identities = 68/270 (25%), Positives = 94/270 (34%), Gaps = 71/270 (26%)
Query: 103 RDPLNGQAVPANGTY-----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
RDP VP NGT E G + F C+ GY L GEE + C + W PP+C
Sbjct: 1489 RDP----GVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544
Query: 158 ----------------EKVLCTPPPKIKNGKHTFS-EVEVFEYLDAVTYSCDP------- 193
P P ++ T + + L +++S +P
Sbjct: 1545 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604
Query: 194 APGPDPFS-LIG-----------EST------IYCGDNSVWSRAAPECKVVKCRFPVVEN 235
GPD S LIG ES+ + D SV K R +
Sbjct: 1605 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1664
Query: 236 GKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCLKVLPP 289
G ++G G + +TV + CD G+ L G T+ C D W+ +P C
Sbjct: 1665 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC------ 1718
Query: 290 SSTKPPALSHSVSTSSTTKSPASSASGYPK 319
P S S + T SP YPK
Sbjct: 1719 ---HAPCGSRSTGSEGTVLSP-----NYPK 1740
Score = 42.0 bits (97), Expect = 0.001
Identities = 15/42 (35%), Positives = 23/42 (54%)
Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
+G F +TV F CD G+ L + ++C+ N W P+P C
Sbjct: 982 YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/268 (22%), Positives = 91/268 (33%), Gaps = 76/268 (28%)
Query: 54 YEIGERVDYKCKKGY--FYIPPLATHTICDRNHTW---LPVSDDAC-------------- 94
+ IG V + C GY + PL +C++NH W LP D C
Sbjct: 986 FSIGSTVSFSCDSGYRLSHEEPL----LCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 1041
Query: 95 -YRE------TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV 147
Y E C + D +G+ V N + H + Y LI E + +
Sbjct: 1042 GYPEFYPNSLNCTWTVDVTHGKGVQFNF-----HTFHLEDHHDYLLITENGSFTQ----- 1091
Query: 148 AIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGEST 207
P+ PP I G + ++ D S
Sbjct: 1092 -------PLARLTGSDLPPTINAGLYGNFRAQLRFISDF-------------------SI 1125
Query: 208 IYCGDNSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Y G N +S E + C P + + G +I G F T+ F C G+ L+G+
Sbjct: 1126 SYEGFNITFS----EYNLEPCEDPGIPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTS 1178
Query: 267 TIVC--DSNSTWDPPVPKCLKVLPPSST 292
I+C W P+P+C+ S+T
Sbjct: 1179 EIICLGGGRRVWSAPLPRCVAECGASAT 1206
Score = 39.7 bits (91), Expect = 0.005
Identities = 35/123 (28%), Positives = 54/123 (43%), Gaps = 24/123 (19%)
Query: 218 RAAPECKVVKCR-FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD----S 272
+A P +C P G++I G +F ++V+F+C+ G+ L GS I C+ S
Sbjct: 1828 QAVPRTSSTQCSSVPEPRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1884
Query: 273 NSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLDVWV 332
+ W+ +P C+ TK T SP GYP+P + L+ VW
Sbjct: 1885 LAQWNDSLPTCIVPCGGILTK---------RKGTILSP-----GYPEPYDNNLNC--VWK 1928
Query: 333 IAV 335
I V
Sbjct: 1929 ITV 1931
Score = 39.7 bits (91), Expect = 0.005
Identities = 58/238 (24%), Positives = 92/238 (38%), Gaps = 59/238 (24%)
Query: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
++CP + P +G + Y G + F C++GY L G + C + G V W+ PI
Sbjct: 2010 DSCPEPQTPSSG--IKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPI 2066
Query: 157 C-----------EKVLCTP------PPK----------IKNGKH----TFSEVEVFEYLD 185
C V+ +P P I G H FS + +YL+
Sbjct: 2067 CLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2126
Query: 186 AVTYSCDPA------PGP----DPFSLIGESTIYCGDNSVWSRAAPECKVV-------KC 228
+ S + + GP FS E+++Y +S +S+ +V C
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF--HSDYSQNKQGFHIVYQAYQLQSC 2184
Query: 229 RFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKC 283
P NG I G F T+ FEC G+ L G+ + C + W+ P+P+C
Sbjct: 2185 PDPRPFRNGFVI---GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2239
Score = 36.2 bits (82), Expect = 0.050
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 5/60 (8%)
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTWDPPVPKCL 284
CR P V +G G++ TV+F+CD G+ L G + I C ++ W P P C+
Sbjct: 1488 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1545
Score = 35.8 bits (81), Expect = 0.065
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 107 NGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC 162
N + + + +E G + + C G+ L+G IL C L G G PP+C+ VLC
Sbjct: 2363 NAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ-VLC 2416
Score = 35.8 bits (81), Expect = 0.065
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 4/38 (10%)
Query: 250 ATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKC 283
+ V + CD+GF L G + VC +S WD PVP C
Sbjct: 2550 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587
Score = 35.4 bits (80), Expect = 0.085
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 4/46 (8%)
Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKC 283
+G +F + + C G+ LDG + C +NS +WD PVP C
Sbjct: 150 YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195
Score = 35.0 bits (79), Expect = 0.11
Identities = 28/96 (29%), Positives = 38/96 (39%), Gaps = 22/96 (22%)
Query: 195 PGPD---PFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKAT 251
PG D FS++ E I N PE NGK+I G F +T
Sbjct: 423 PGKDNSNKFSILNEGGIKTASNLCPDPGEPE------------NGKRI---GSDFSLGST 467
Query: 252 VMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKC 283
V F CD+ + L G+ +I C + + W P C
Sbjct: 468 VQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Score = 33.9 bits (76), Expect = 0.25
Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 2/44 (4%)
Query: 243 GKKFYYKATVMFECDKGFYLDGSDTIVCDSNST--WDPPVPKCL 284
G ++ V F+CD+G+ L G I C W+ P+P CL
Sbjct: 2025 GDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2068
Score = 32.7 bits (73), Expect = 0.55
Identities = 26/86 (30%), Positives = 35/86 (40%), Gaps = 4/86 (4%)
Query: 77 HTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE 136
H+ +N + A ++CP R NG + + G + F C GY LIG
Sbjct: 2162 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGN 2219
Query: 137 EILYCELKGSVAIWSGKPPICEKVLC 162
L C L G W+ P CE LC
Sbjct: 2220 SALTC-LHGVSRNWNHPLPRCE-ALC 2243
Score = 32.3 bits (72), Expect = 0.72
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 3/60 (5%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPIC 157
CP P+N + N ++ G + IC EG+ G E + C L +WSG P C
Sbjct: 794 CPDPGIPINARRFGDN--FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851
Score = 32.3 bits (72), Expect = 0.72
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 3/60 (5%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWSGKPPIC 157
C + +P G+ + + G + F CN GY L G + CE + S+A W+ P C
Sbjct: 1838 CSSVPEPRFGRRI--GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1895
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 110 bits (274), Expect = 3e-24
Identities = 80/251 (31%), Positives = 112/251 (44%), Gaps = 23/251 (9%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Y +G+ V Y C+ GY + C N TW V C TCP NG+
Sbjct: 3020 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP-TCRAVTCPTPPQISNGRLEGT 3078
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
N +++G+ + +IC+ GY L +L C G+ WSG+ P C C P GK
Sbjct: 3079 N--FDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKR 3133
Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC---KVVKCRF 230
E + F Y V++SC+ PF L+G ST C + WS ++P C C
Sbjct: 3134 ---EGKSFIYQSEVSFSCN-----FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN 3185
Query: 231 P-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
P V +G Q + FG F + V F C KG L GS T C + TW P+C +P
Sbjct: 3186 PGVPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC---IPH 3240
Query: 290 SSTKPPALSHS 300
S +P +H+
Sbjct: 3241 SCKQPETPAHA 3251
Score = 103 bits (258), Expect = 2e-22
Identities = 76/248 (30%), Positives = 106/248 (42%), Gaps = 32/248 (12%)
Query: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT--- 116
V Y C +GY P C N TW + C +C DP +PANG
Sbjct: 2968 VIYSCMEGYILSGPSVRQ--CTANGTWSGTLPN-CTIISCG---DP----GIPANGLRYG 3017
Query: 117 --YEFGYQMHFICNEGYY--LIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
Y G + ++C GY L G I C + G+ WSG P C V C PP+I NG+
Sbjct: 3018 DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGR 3074
Query: 173 HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP- 231
E F++ +++Y C P + L + + C N WS P+C C P
Sbjct: 3075 ---LEGTNFDWGFSISYICSPG-----YELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3126
Query: 232 VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSS 291
+ GK+ GK F Y++ V F C+ F L GS T +C ++ TW P C++ S
Sbjct: 3127 IPAQGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSC 3183
Query: 292 TKPPALSH 299
P H
Sbjct: 3184 ENPGVPRH 3191
Score = 102 bits (254), Expect = 6e-22
Identities = 73/257 (28%), Positives = 112/257 (43%), Gaps = 25/257 (9%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
+C E PT IG Y G + C G+ + C + W S+
Sbjct: 2589 SCGELPTPPNGNKIGTQTSY---GSTAIFTCDLGFMLVGSAVRE--CLSSGLWSE-SETR 2642
Query: 94 CYRETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWS 151
C C +NGQ + N +GY+ + + CN G+ LIG + C+ + WS
Sbjct: 2643 CLAGHCGIPELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHN---WS 2695
Query: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
G+ P C V C P G+ + + F + D VT+SC+ + + G + C
Sbjct: 2696 GQLPSCVPVSCGHPGSPIYGRTSGNG---FNFNDVVTFSCNIG-----YLMQGPTKAQCQ 2747
Query: 212 DNSVWSRAAPECKVVKCRFP-VVENGKQISGFGK-KFYYKATVMFECDKGFYLDGSDTIV 269
N WS P CKVV C P + N K+ S F Y V ++C+ G++L GS ++
Sbjct: 2748 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2807
Query: 270 CDSNSTWDPPVPKCLKV 286
C N WD P+P+C+ +
Sbjct: 2808 CQPNGQWDKPLPECIMI 2824
Score = 101 bits (251), Expect = 1e-21
Identities = 76/262 (29%), Positives = 102/262 (38%), Gaps = 26/262 (9%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVS-DDACYRETCPYIRDPLNGQAVP 112
Y +G RV Y C GY T +C + TW + C +C + P NG +
Sbjct: 2544 YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIG 2603
Query: 113 ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
+Y G F C+ G+ L+G + C G +WS C C P I NG+
Sbjct: 2604 TQTSY--GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQ 2658
Query: 173 HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV 232
E + Y D V Y C+P F LIG S C + WS P C V C P
Sbjct: 2659 VI---GENYGYRDTVVYQCNPG-----FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP- 2709
Query: 233 VENGKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV---- 286
G I G G F + V F C+ G+ + G C +N W P P C V
Sbjct: 2710 ---GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSD 2766
Query: 287 --LPPSSTKPPALSHSVSTSST 306
+P +S + + H T T
Sbjct: 2767 PGIPANSKRESKIEHGNFTYGT 2788
Score = 88.2 bits (217), Expect = 1e-17
Identities = 70/235 (29%), Positives = 95/235 (40%), Gaps = 24/235 (10%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTW-LPVSDDACYRETCPYIRDPLNGQAVP 112
+ G V Y C GYF ++ IC N W P+ + C C + P N AV
Sbjct: 2784 FTYGTVVFYDCNPGYFLFG--SSVLICQPNGQWDKPLPE--CIMIDCGHPGVPPN--AVL 2837
Query: 113 ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE---KVLCTPPPKIK 169
+ Y FG +H+ C L+G+ C+L G WSG P C C P
Sbjct: 2838 SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG 2894
Query: 170 NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
+G S F V Y+CD + L G C N W+ PECK V+C
Sbjct: 2895 HGSRQESN---FRTKSTVRYACDTG-----YILHGSEERTCLANGSWTGRQPECKAVQCG 2946
Query: 230 FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
P NGK G F ++V++ C +G+ L G C +N TW +P C
Sbjct: 2947 NPGTTANGKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC 2999
Score = 80.9 bits (198), Expect = 2e-15
Identities = 68/245 (27%), Positives = 97/245 (39%), Gaps = 35/245 (14%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNG--QAV 111
+ + V + C GY P T C N W C C P N ++
Sbjct: 2722 FNFNDVVTFSCNIGYLMQGP--TKAQCQANRQWSH-PPPMCKVVNCSDPGIPANSKRESK 2778
Query: 112 PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC----TPPPK 167
+G + +G + + CN GY+L G +L C+ G W P C + C PP
Sbjct: 2779 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNA 2835
Query: 168 IKNG-KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK-- 224
+ +G K+TF V YSC SL+G+S+ C N WS + P C
Sbjct: 2836 VLSGEKYTFGST--------VHYSCTGKR-----SLLGQSSRTCQLNGHWSGSQPHCSGD 2882
Query: 225 -VVKCRFPVV--ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
C P +Q S F K +TV + CD G+ L GS+ C +N +W P
Sbjct: 2883 ATGTCGDPGTPGHGSRQESNFRTK----STVRYACDTGYILHGSEERTCLANGSWTGRQP 2938
Query: 282 KCLKV 286
+C V
Sbjct: 2939 ECKAV 2943
Score = 70.5 bits (171), Expect = 2e-12
Identities = 80/284 (28%), Positives = 111/284 (39%), Gaps = 47/284 (16%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDA 93
C PP L G ++ G + Y C GY P + T C N TW
Sbjct: 3064 CPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLT---CVGNGTWSGEVPQ- 3116
Query: 94 CYRETCPYIRDPLNGQAVPANGTYE---FGYQ--MHFICNEGYYLIGEEILYCELKGSVA 148
C + C DP +PA G E F YQ + F CN + L+G C+ G+
Sbjct: 3117 CLPKFCG---DP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT-- 3167
Query: 149 IWSGKPPIC---EKVLCTPP--PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
WSG P C + C P P+ + +TF F+ V + C L
Sbjct: 3168 -WSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKG-----HLLQ 3217
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYL- 262
G +T C + WS PEC C+ P + G + T+++ C GF+L
Sbjct: 3218 GSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH-GYTLIYTCQPGFFLA 3276
Query: 263 DGSDTIVCDSNSTWDPPVPKC---LKVL-----PPSSTKPPALS 298
G++ VC S++TW VP C K+L P T P LS
Sbjct: 3277 GGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLS 3320
Score = 66.6 bits (161), Expect = 3e-11
Identities = 52/194 (26%), Positives = 77/194 (39%), Gaps = 22/194 (11%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSGKPPIC 157
C P +G + G + + + C+ G+ L+G+ C W P C
Sbjct: 2465 CSTPESPPHGYIISQTGG-QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2523
Query: 158 EKVLCTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGE--STIYCGDN 213
+ + C P NG + +YL VTY C+ D + L + +T C +
Sbjct: 2524 QAISCGIPKAPTNG-----GILTTDYLVGTRVTYFCN-----DGYRLSSKELTTAVCQSD 2573
Query: 214 SVWS--RAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC 270
WS P C V+ C P NG +I G + Y +T +F CD GF L GS C
Sbjct: 2574 GTWSNHNKTPRCVVISCGELPTPPNGNKI---GTQTSYGSTAIFTCDLGFMLVGSAVREC 2630
Query: 271 DSNSTWDPPVPKCL 284
S+ W +CL
Sbjct: 2631 LSSGLWSESETRCL 2644
Score = 51.2 bits (121), Expect = 1e-06
Identities = 67/285 (23%), Positives = 104/285 (36%), Gaps = 69/285 (24%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPIC 157
CP +P NG+ + ++ + G + F C+E Y L G + + C+ V A WS P+C
Sbjct: 382 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439
Query: 158 EKVLCTPPPKIKNGKHTF--------SEVEVFEYLDAVTYSCDPAPGPDPFSL-IGESTI 208
+ C + +G T S + + AV + + F L IG T+
Sbjct: 440 KVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTL 499
Query: 209 YCGD---------------------------NSVWSRAAPECKVVKCRFPVV-------- 233
GD + +W + V F V
Sbjct: 500 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 559
Query: 234 --ENGKQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
+ G + G G F + + FEC GF L G +IVC N+ W +P C+
Sbjct: 560 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF---- 615
Query: 290 SSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLD-VWVI 333
P LS+ + T SP YP EG ++L+ +W I
Sbjct: 616 -----PCLSNFTAPMGTVLSP-----DYP---EGYGNNLNCIWTI 647
Score = 43.5 bits (101), Expect = 3e-04
Identities = 68/270 (25%), Positives = 94/270 (34%), Gaps = 71/270 (26%)
Query: 103 RDPLNGQAVPANGTY-----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
RDP VP NGT E G + F C+ GY L GEE + C + W PP+C
Sbjct: 1425 RDP----GVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480
Query: 158 ----------------EKVLCTPPPKIKNGKHTFS-EVEVFEYLDAVTYSCDP------- 193
P P ++ T + + L +++S +P
Sbjct: 1481 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1540
Query: 194 APGPDPFS-LIG-----------EST------IYCGDNSVWSRAAPECKVVKCRFPVVEN 235
GPD S LIG ES+ + D SV K R +
Sbjct: 1541 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1600
Query: 236 GKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCLKVLPP 289
G ++G G + +TV + CD G+ L G T+ C D W+ +P C
Sbjct: 1601 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC------ 1654
Query: 290 SSTKPPALSHSVSTSSTTKSPASSASGYPK 319
P S S + T SP YPK
Sbjct: 1655 ---HAPCGSRSTGSEGTVLSP-----NYPK 1676
Score = 42.0 bits (97), Expect = 0.001
Identities = 15/42 (35%), Positives = 23/42 (54%)
Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
+G F +TV F CD G+ L + ++C+ N W P+P C
Sbjct: 918 YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 959
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/268 (22%), Positives = 91/268 (33%), Gaps = 76/268 (28%)
Query: 54 YEIGERVDYKCKKGY--FYIPPLATHTICDRNHTW---LPVSDDAC-------------- 94
+ IG V + C GY + PL +C++NH W LP D C
Sbjct: 922 FSIGSTVSFSCDSGYRLSHEEPL----LCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 977
Query: 95 -YRE------TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV 147
Y E C + D +G+ V N + H + Y LI E + +
Sbjct: 978 GYPEFYPNSLNCTWTVDVTHGKGVQFNF-----HTFHLEDHHDYLLITENGSFTQ----- 1027
Query: 148 AIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGEST 207
P+ PP I G + ++ D S
Sbjct: 1028 -------PLARLTGSDLPPTINAGLYGNFRAQLRFISDF-------------------SI 1061
Query: 208 IYCGDNSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Y G N +S E + C P + + G +I G F T+ F C G+ L+G+
Sbjct: 1062 SYEGFNITFS----EYNLEPCEDPGIPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTS 1114
Query: 267 TIVC--DSNSTWDPPVPKCLKVLPPSST 292
I+C W P+P+C+ S+T
Sbjct: 1115 EIICLGGGRRVWSAPLPRCVAECGASAT 1142
Score = 39.7 bits (91), Expect = 0.005
Identities = 35/123 (28%), Positives = 54/123 (43%), Gaps = 24/123 (19%)
Query: 218 RAAPECKVVKCR-FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD----S 272
+A P +C P G++I G +F ++V+F+C+ G+ L GS I C+ S
Sbjct: 1764 QAVPRTSSTQCSSVPEPRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1820
Query: 273 NSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLDVWV 332
+ W+ +P C+ TK T SP GYP+P + L+ VW
Sbjct: 1821 LAQWNDSLPTCIVPCGGILTK---------RKGTILSP-----GYPEPYDNNLNC--VWK 1864
Query: 333 IAV 335
I V
Sbjct: 1865 ITV 1867
Score = 39.7 bits (91), Expect = 0.005
Identities = 58/238 (24%), Positives = 92/238 (38%), Gaps = 59/238 (24%)
Query: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
++CP + P +G + Y G + F C++GY L G + C + G V W+ PI
Sbjct: 1946 DSCPEPQTPSSG--IKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPI 2002
Query: 157 C-----------EKVLCTP------PPK----------IKNGKH----TFSEVEVFEYLD 185
C V+ +P P I G H FS + +YL+
Sbjct: 2003 CLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2062
Query: 186 AVTYSCDPA------PGP----DPFSLIGESTIYCGDNSVWSRAAPECKVV-------KC 228
+ S + + GP FS E+++Y +S +S+ +V C
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF--HSDYSQNKQGFHIVYQAYQLQSC 2120
Query: 229 RFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKC 283
P NG I G F T+ FEC G+ L G+ + C + W+ P+P+C
Sbjct: 2121 PDPRPFRNGFVI---GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2175
Score = 38.9 bits (89), Expect = 0.008
Identities = 64/268 (23%), Positives = 102/268 (38%), Gaps = 60/268 (22%)
Query: 54 YEIGERVDYKCKKGYFYI--PPLATHTICDRNHTW---LPV--SDDAC---YRETCPYIR 103
+++G+++ Y C GY P L +W +P+ ++DAC R + I
Sbjct: 194 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIIS 253
Query: 104 DPL--NGQAVPANGTY----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
P N A+ T+ E G + I + + + E+ Y E++GS P I
Sbjct: 254 SPSFPNEYHNNADCTWTIVAEPGDTISLIFTD--FQMEEKYDYLEIEGSEP-----PTIW 306
Query: 158 EKVLCTPPPKIKN-----------GKHTF----SEVEVFEYLDAVTYSCDPAPGPD---P 199
+ PPP I N H + + +V + +D + PG D
Sbjct: 307 LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNK 366
Query: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKG 259
FS++ E I N PE NGK+I G F +TV F CD+
Sbjct: 367 FSILNEGGIKTASNLCPDPGEPE------------NGKRI---GSDFSLGSTVQFSCDED 411
Query: 260 FYLDGSDTIVC----DSNSTWDPPVPKC 283
+ L G+ +I C + + W P C
Sbjct: 412 YVLQGAKSITCQRIAEVFAAWSDHRPVC 439
Score = 36.2 bits (82), Expect = 0.050
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 5/60 (8%)
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTWDPPVPKCL 284
CR P V +G G++ TV+F+CD G+ L G + I C ++ W P P C+
Sbjct: 1424 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1481
Score = 35.8 bits (81), Expect = 0.065
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 107 NGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC 162
N + + + +E G + + C G+ L+G IL C L G G PP+C+ VLC
Sbjct: 2299 NAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ-VLC 2352
Score = 35.4 bits (80), Expect = 0.085
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 4/46 (8%)
Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKC 283
+G +F + + C G+ LDG + C +NS +WD PVP C
Sbjct: 190 YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235
Score = 33.9 bits (76), Expect = 0.25
Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 2/44 (4%)
Query: 243 GKKFYYKATVMFECDKGFYLDGSDTIVCDSNST--WDPPVPKCL 284
G ++ V F+CD+G+ L G I C W+ P+P CL
Sbjct: 1961 GDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2004
Score = 32.7 bits (73), Expect = 0.55
Identities = 26/86 (30%), Positives = 35/86 (40%), Gaps = 4/86 (4%)
Query: 77 HTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE 136
H+ +N + A ++CP R NG + + G + F C GY LIG
Sbjct: 2098 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGN 2155
Query: 137 EILYCELKGSVAIWSGKPPICEKVLC 162
L C L G W+ P CE LC
Sbjct: 2156 SALTC-LHGVSRNWNHPLPRCE-ALC 2179
Score = 32.3 bits (72), Expect = 0.72
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 3/60 (5%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPIC 157
CP P+N + N ++ G + IC EG+ G E + C L +WSG P C
Sbjct: 730 CPDPGIPINARRFGDN--FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787
Score = 32.3 bits (72), Expect = 0.72
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 3/60 (5%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWSGKPPIC 157
C + +P G+ + + G + F CN GY L G + CE + S+A W+ P C
Sbjct: 1774 CSSVPEPRFGRRI--GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1831
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 110 bits (274), Expect = 3e-24
Identities = 80/251 (31%), Positives = 112/251 (44%), Gaps = 23/251 (9%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Y +G+ V Y C+ GY + C N TW V C TCP NG+
Sbjct: 3189 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP-TCRAVTCPTPPQISNGRLEGT 3247
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
N +++G+ + +IC+ GY L +L C G+ WSG+ P C C P GK
Sbjct: 3248 N--FDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKR 3302
Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC---KVVKCRF 230
E + F Y V++SC+ PF L+G ST C + WS ++P C C
Sbjct: 3303 ---EGKSFIYQSEVSFSCN-----FPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN 3354
Query: 231 P-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
P V +G Q + FG F + V F C KG L GS T C + TW P+C +P
Sbjct: 3355 PGVPRHGSQNNTFG--FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC---IPH 3409
Query: 290 SSTKPPALSHS 300
S +P +H+
Sbjct: 3410 SCKQPETPAHA 3420
Score = 103 bits (258), Expect = 2e-22
Identities = 76/248 (30%), Positives = 106/248 (42%), Gaps = 32/248 (12%)
Query: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT--- 116
V Y C +GY P C N TW + C +C DP +PANG
Sbjct: 3137 VIYSCMEGYILSGPSVRQ--CTANGTWSGTLPN-CTIISCG---DP----GIPANGLRYG 3186
Query: 117 --YEFGYQMHFICNEGYY--LIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGK 172
Y G + ++C GY L G I C + G+ WSG P C V C PP+I NG+
Sbjct: 3187 DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGR 3243
Query: 173 HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP- 231
E F++ +++Y C P + L + + C N WS P+C C P
Sbjct: 3244 ---LEGTNFDWGFSISYICSPG-----YELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG 3295
Query: 232 VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSS 291
+ GK+ GK F Y++ V F C+ F L GS T +C ++ TW P C++ S
Sbjct: 3296 IPAQGKRE---GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSC 3352
Query: 292 TKPPALSH 299
P H
Sbjct: 3353 ENPGVPRH 3360
Score = 102 bits (254), Expect = 6e-22
Identities = 73/257 (28%), Positives = 112/257 (43%), Gaps = 25/257 (9%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
+C E PT IG Y G + C G+ + C + W S+
Sbjct: 2758 SCGELPTPPNGNKIGTQTSY---GSTAIFTCDLGFMLVGSAVRE--CLSSGLWSE-SETR 2811
Query: 94 CYRETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWS 151
C C +NGQ + N +GY+ + + CN G+ LIG + C+ + WS
Sbjct: 2812 CLAGHCGIPELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHN---WS 2864
Query: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
G+ P C V C P G+ + + F + D VT+SC+ + + G + C
Sbjct: 2865 GQLPSCVPVSCGHPGSPIYGRTSGNG---FNFNDVVTFSCNIG-----YLMQGPTKAQCQ 2916
Query: 212 DNSVWSRAAPECKVVKCRFP-VVENGKQISGFGK-KFYYKATVMFECDKGFYLDGSDTIV 269
N WS P CKVV C P + N K+ S F Y V ++C+ G++L GS ++
Sbjct: 2917 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2976
Query: 270 CDSNSTWDPPVPKCLKV 286
C N WD P+P+C+ +
Sbjct: 2977 CQPNGQWDKPLPECIMI 2993
Score = 102 bits (253), Expect = 7e-22
Identities = 66/238 (27%), Positives = 109/238 (45%), Gaps = 17/238 (7%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVS-DDACYRETCPYIRDPL--NGQA 110
Y +G RV Y C GY T +C + TW + C TCP I + +G+
Sbjct: 2648 YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRW 2707
Query: 111 VPANGT-YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
NG+ YE+ ++ F C+ GY+ +G + C G+ + W + P C+ + C P
Sbjct: 2708 RIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS-WRNERPYCQIISCGELPTPP 2766
Query: 170 NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
NG ++ Y ++CD F L+G + C + +WS + C C
Sbjct: 2767 NGNKIGTQT---SYGSTAIFTCDLG-----FMLVGSAVRECLSSGLWSESETRCLAGHCG 2818
Query: 230 FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
P ++ NG+ I G+ + Y+ TV+++C+ GF L GS +C + W +P C+ V
Sbjct: 2819 IPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV 2873
Score = 95.9 bits (237), Expect = 5e-20
Identities = 75/263 (28%), Positives = 104/263 (39%), Gaps = 28/263 (10%)
Query: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD-DACYRETCPYIRDPLNGQAV 111
+YE +V + C GY + P + C N TW ++ C +C + P NG +
Sbjct: 2714 HYEYKTKVVFSCDPGYHGLGPASIE--CLPNGTWSWRNERPYCQIISCGELPTPPNGNKI 2771
Query: 112 PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG 171
+Y G F C+ G+ L+G + C G +WS C C P I NG
Sbjct: 2772 GTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNG 2826
Query: 172 KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP 231
+ E + Y D V Y C+P F LIG S C + WS P C V C P
Sbjct: 2827 QVI---GENYGYRDTVVYQCNPG-----FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP 2878
Query: 232 VVENGKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV--- 286
G I G G F + V F C+ G+ + G C +N W P P C V
Sbjct: 2879 ----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCS 2934
Query: 287 ---LPPSSTKPPALSHSVSTSST 306
+P +S + + H T T
Sbjct: 2935 DPGIPANSKRESKIEHGNFTYGT 2957
Score = 88.2 bits (217), Expect = 1e-17
Identities = 70/235 (29%), Positives = 95/235 (40%), Gaps = 24/235 (10%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTW-LPVSDDACYRETCPYIRDPLNGQAVP 112
+ G V Y C GYF ++ IC N W P+ + C C + P N AV
Sbjct: 2953 FTYGTVVFYDCNPGYFLFG--SSVLICQPNGQWDKPLPE--CIMIDCGHPGVPPN--AVL 3006
Query: 113 ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE---KVLCTPPPKIK 169
+ Y FG +H+ C L+G+ C+L G WSG P C C P
Sbjct: 3007 SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPG 3063
Query: 170 NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR 229
+G S F V Y+CD + L G C N W+ PECK V+C
Sbjct: 3064 HGSRQESN---FRTKSTVRYACDTG-----YILHGSEERTCLANGSWTGRQPECKAVQCG 3115
Query: 230 FP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
P NGK G F ++V++ C +G+ L G C +N TW +P C
Sbjct: 3116 NPGTTANGKVFRIDGTTF--SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC 3168
Score = 80.9 bits (198), Expect = 2e-15
Identities = 68/245 (27%), Positives = 97/245 (39%), Gaps = 35/245 (14%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNG--QAV 111
+ + V + C GY P T C N W C C P N ++
Sbjct: 2891 FNFNDVVTFSCNIGYLMQGP--TKAQCQANRQWSH-PPPMCKVVNCSDPGIPANSKRESK 2947
Query: 112 PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC----TPPPK 167
+G + +G + + CN GY+L G +L C+ G W P C + C PP
Sbjct: 2948 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNA 3004
Query: 168 IKNG-KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK-- 224
+ +G K+TF V YSC SL+G+S+ C N WS + P C
Sbjct: 3005 VLSGEKYTFGST--------VHYSCTGKR-----SLLGQSSRTCQLNGHWSGSQPHCSGD 3051
Query: 225 -VVKCRFPVV--ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
C P +Q S F K +TV + CD G+ L GS+ C +N +W P
Sbjct: 3052 ATGTCGDPGTPGHGSRQESNFRTK----STVRYACDTGYILHGSEERTCLANGSWTGRQP 3107
Query: 282 KCLKV 286
+C V
Sbjct: 3108 ECKAV 3112
Score = 70.5 bits (171), Expect = 2e-12
Identities = 80/284 (28%), Positives = 111/284 (39%), Gaps = 47/284 (16%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY-FYIPPLATHTICDRNHTWLPVSDDA 93
C PP L G ++ G + Y C GY P + T C N TW
Sbjct: 3233 CPTPPQISNGRLEGTN---FDWGFSISYICSPGYELSFPAVLT---CVGNGTWSGEVPQ- 3285
Query: 94 CYRETCPYIRDPLNGQAVPANGTYE---FGYQ--MHFICNEGYYLIGEEILYCELKGSVA 148
C + C DP +PA G E F YQ + F CN + L+G C+ G+
Sbjct: 3286 CLPKFCG---DP----GIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGT-- 3336
Query: 149 IWSGKPPIC---EKVLCTPP--PKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
WSG P C + C P P+ + +TF F+ V + C L
Sbjct: 3337 -WSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG----FQVGSVVQFHCKKG-----HLLQ 3386
Query: 204 GESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYL- 262
G +T C + WS PEC C+ P + G + T+++ C GF+L
Sbjct: 3387 GSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH-GYTLIYTCQPGFFLA 3445
Query: 263 DGSDTIVCDSNSTWDPPVPKC---LKVL-----PPSSTKPPALS 298
G++ VC S++TW VP C K+L P T P LS
Sbjct: 3446 GGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLS 3489
Score = 62.8 bits (151), Expect = 5e-10
Identities = 49/188 (26%), Positives = 76/188 (40%), Gaps = 21/188 (11%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSGKPPIC 157
C P +G + G + + + C+ G+ L+G+ C W P C
Sbjct: 2569 CSTPESPPHGYIISQTGG-QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2627
Query: 158 EKVLCTPPPKIKNGKHTFSEVEVFEYL--DAVTYSCDPAPGPDPFSLIGE--STIYCGDN 213
+ + C P NG + +YL VTY C+ D + L + +T C +
Sbjct: 2628 QAISCGIPKAPTNGG-----ILTTDYLVGTRVTYFCN-----DGYRLSSKELTTAVCQSD 2677
Query: 214 SVWSR--AAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTI 268
WS P C VV C ++E+G+ G + YK V+F CD G++ G +I
Sbjct: 2678 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI 2737
Query: 269 VCDSNSTW 276
C N TW
Sbjct: 2738 ECLPNGTW 2745
Score = 51.2 bits (121), Expect = 1e-06
Identities = 67/285 (23%), Positives = 104/285 (36%), Gaps = 69/285 (24%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV-AIWSGKPPIC 157
CP +P NG+ + ++ + G + F C+E Y L G + + C+ V A WS P+C
Sbjct: 486 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 158 EKVLCTPPPKIKNGKHTF--------SEVEVFEYLDAVTYSCDPAPGPDPFSL-IGESTI 208
+ C + +G T S + + AV + + F L IG T+
Sbjct: 544 KVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTL 603
Query: 209 YCGD---------------------------NSVWSRAAPECKVVKCRFPVV-------- 233
GD + +W + V F V
Sbjct: 604 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 663
Query: 234 --ENGKQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
+ G + G G F + + FEC GF L G +IVC N+ W +P C+
Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF---- 719
Query: 290 SSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLD-VWVI 333
P LS+ + T SP YP EG ++L+ +W I
Sbjct: 720 -----PCLSNFTAPMGTVLSP-----DYP---EGYGNNLNCIWTI 751
Score = 43.5 bits (101), Expect = 3e-04
Identities = 68/270 (25%), Positives = 94/270 (34%), Gaps = 71/270 (26%)
Query: 103 RDPLNGQAVPANGTY-----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
RDP VP NGT E G + F C+ GY L GEE + C + W PP+C
Sbjct: 1529 RDP----GVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584
Query: 158 ----------------EKVLCTPPPKIKNGKHTFS-EVEVFEYLDAVTYSCDP------- 193
P P ++ T + + L +++S +P
Sbjct: 1585 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1644
Query: 194 APGPDPFS-LIG-----------EST------IYCGDNSVWSRAAPECKVVKCRFPVVEN 235
GPD S LIG ES+ + D SV K R +
Sbjct: 1645 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1704
Query: 236 GKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKCLKVLPP 289
G ++G G + +TV + CD G+ L G T+ C D W+ +P C
Sbjct: 1705 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC------ 1758
Query: 290 SSTKPPALSHSVSTSSTTKSPASSASGYPK 319
P S S + T SP YPK
Sbjct: 1759 ---HAPCGSRSTGSEGTVLSP-----NYPK 1780
Score = 42.0 bits (97), Expect = 0.001
Identities = 15/42 (35%), Positives = 23/42 (54%)
Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
+G F +TV F CD G+ L + ++C+ N W P+P C
Sbjct: 1022 YGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/268 (22%), Positives = 91/268 (33%), Gaps = 76/268 (28%)
Query: 54 YEIGERVDYKCKKGY--FYIPPLATHTICDRNHTW---LPVSDDAC-------------- 94
+ IG V + C GY + PL +C++NH W LP D C
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPL----LCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 1081
Query: 95 -YRE------TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSV 147
Y E C + D +G+ V N + H + Y LI E + +
Sbjct: 1082 GYPEFYPNSLNCTWTVDVTHGKGVQFNF-----HTFHLEDHHDYLLITENGSFTQ----- 1131
Query: 148 AIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGEST 207
P+ PP I G + ++ D S
Sbjct: 1132 -------PLARLTGSDLPPTINAGLYGNFRAQLRFISDF-------------------SI 1165
Query: 208 IYCGDNSVWSRAAPECKVVKCRFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSD 266
Y G N +S E + C P + + G +I G F T+ F C G+ L+G+
Sbjct: 1166 SYEGFNITFS----EYNLEPCEDPGIPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTS 1218
Query: 267 TIVC--DSNSTWDPPVPKCLKVLPPSST 292
I+C W P+P+C+ S+T
Sbjct: 1219 EIICLGGGRRVWSAPLPRCVAECGASAT 1246
Score = 39.7 bits (91), Expect = 0.005
Identities = 35/123 (28%), Positives = 54/123 (43%), Gaps = 24/123 (19%)
Query: 218 RAAPECKVVKCR-FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCD----S 272
+A P +C P G++I G +F ++V+F+C+ G+ L GS I C+ S
Sbjct: 1868 QAVPRTSSTQCSSVPEPRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNS 1924
Query: 273 NSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLDVWV 332
+ W+ +P C+ TK T SP GYP+P + L+ VW
Sbjct: 1925 LAQWNDSLPTCIVPCGGILTK---------RKGTILSP-----GYPEPYDNNLNC--VWK 1968
Query: 333 IAV 335
I V
Sbjct: 1969 ITV 1971
Score = 39.7 bits (91), Expect = 0.005
Identities = 58/238 (24%), Positives = 92/238 (38%), Gaps = 59/238 (24%)
Query: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
++CP + P +G + Y G + F C++GY L G + C + G V W+ PI
Sbjct: 2050 DSCPEPQTPSSG--IKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPGPVRRWNYPIPI 2106
Query: 157 C-----------EKVLCTP------PPK----------IKNGKH----TFSEVEVFEYLD 185
C V+ +P P I G H FS + +YL+
Sbjct: 2107 CLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2166
Query: 186 AVTYSCDPA------PGP----DPFSLIGESTIYCGDNSVWSRAAPECKVV-------KC 228
+ S + + GP FS E+++Y +S +S+ +V C
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYF--HSDYSQNKQGFHIVYQAYQLQSC 2224
Query: 229 RFP-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKC 283
P NG I G F T+ FEC G+ L G+ + C + W+ P+P+C
Sbjct: 2225 PDPRPFRNGFVI---GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2279
Score = 36.2 bits (82), Expect = 0.050
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 5/60 (8%)
Query: 228 CRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC---DSNSTWDPPVPKCL 284
CR P V +G G++ TV+F+CD G+ L G + I C ++ W P P C+
Sbjct: 1528 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1585
Score = 35.8 bits (81), Expect = 0.065
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 107 NGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLC 162
N + + + +E G + + C G+ L+G IL C L G G PP+C+ VLC
Sbjct: 2403 NAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMDGAPPVCQ-VLC 2456
Score = 35.8 bits (81), Expect = 0.065
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 4/38 (10%)
Query: 250 ATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKC 283
+ V + CD+GF L G + VC +S WD PVP C
Sbjct: 2590 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2627
Score = 35.4 bits (80), Expect = 0.085
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 4/46 (8%)
Query: 242 FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS----TWDPPVPKC 283
+G +F + + C G+ LDG + C +NS +WD PVP C
Sbjct: 190 YGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235
Score = 35.0 bits (79), Expect = 0.11
Identities = 28/96 (29%), Positives = 38/96 (39%), Gaps = 22/96 (22%)
Query: 195 PGPD---PFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKAT 251
PG D FS++ E I N PE NGK+I G F +T
Sbjct: 463 PGKDNSNKFSILNEGGIKTASNLCPDPGEPE------------NGKRI---GSDFSLGST 507
Query: 252 VMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKC 283
V F CD+ + L G+ +I C + + W P C
Sbjct: 508 VQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Score = 33.9 bits (76), Expect = 0.25
Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 2/44 (4%)
Query: 243 GKKFYYKATVMFECDKGFYLDGSDTIVCDSNST--WDPPVPKCL 284
G ++ V F+CD+G+ L G I C W+ P+P CL
Sbjct: 2065 GDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2108
Score = 32.7 bits (73), Expect = 0.55
Identities = 26/86 (30%), Positives = 35/86 (40%), Gaps = 4/86 (4%)
Query: 77 HTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE 136
H+ +N + A ++CP R NG + + G + F C GY LIG
Sbjct: 2202 HSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGN 2259
Query: 137 EILYCELKGSVAIWSGKPPICEKVLC 162
L C L G W+ P CE LC
Sbjct: 2260 SALTC-LHGVSRNWNHPLPRCE-ALC 2283
Score = 32.3 bits (72), Expect = 0.72
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 3/60 (5%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPIC 157
CP P+N + N ++ G + IC EG+ G E + C L +WSG P C
Sbjct: 834 CPDPGIPINARRFGDN--FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891
Score = 32.3 bits (72), Expect = 0.72
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 3/60 (5%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWSGKPPIC 157
C + +P G+ + + G + F CN GY L G + CE + S+A W+ P C
Sbjct: 1878 CSSVPEPRFGRRI--GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1935
>gi|153266841 apolipoprotein H precursor [Homo sapiens]
Length = 345
Score = 108 bits (271), Expect = 6e-24
Identities = 75/242 (30%), Positives = 106/242 (43%), Gaps = 28/242 (11%)
Query: 51 KPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQA 110
K +YE GE + Y CK GY + IC W P++ C CP+ NG
Sbjct: 38 KTFYEPGEEITYSCKPGYVSRGGMRKF-ICPLTGLW-PINTLKCTPRVCPFAGILENGAV 95
Query: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN 170
T+E+ + F CN G+YL G + C +G WS + P+C ++C PPP I
Sbjct: 96 --RYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGK---WSPELPVCAPIIC-PPPSIP- 148
Query: 171 GKHTFSEVEVFE--------YLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
TF+ + V++ Y D + C P ++ G TI C + W++ PE
Sbjct: 149 ---TFATLRVYKPSAGNNSLYRDTAVFECLPQ-----HAMFGNDTITCTTHGNWTKL-PE 199
Query: 223 CKVVKCRFPV-VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
C+ VKC FP +NG YYK F C G+ LDG + I C W +P
Sbjct: 200 CREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMP 258
Query: 282 KC 283
C
Sbjct: 259 SC 260
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 17/202 (8%)
Query: 98 TCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILY-CELKGSVAIWSGKPPI 156
TCP D VP YE G ++ + C GY G + C L G +W
Sbjct: 22 TCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG---LWPINTLK 78
Query: 157 CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVW 216
C +C ++NG ++ FEY + +++SC+ F L G + C + W
Sbjct: 79 CTPRVCPFAGILENGAVRYT---TFEYPNTISFSCNTG-----FYLNGADSAKCTEEGKW 130
Query: 217 SRAAPECKVVKCRFPVVENGKQISGF----GKKFYYKATVMFECDKGFYLDGSDTIVCDS 272
S P C + C P + + + G Y+ T +FEC + G+DTI C +
Sbjct: 131 SPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTT 190
Query: 273 NSTWDPPVPKCLKVLPPSSTKP 294
+ W +P+C +V P ++P
Sbjct: 191 HGNW-TKLPECREVKCPFPSRP 211
>gi|168693643 decay accelerating factor for complement isoform 2
precursor [Homo sapiens]
Length = 440
Score = 107 bits (266), Expect = 2e-23
Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)
Query: 34 ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
+CE P + L + Y+ +G V+Y+C+ GY P L+ C +N W +
Sbjct: 97 SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
Query: 92 DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151
+ C +++CP + NGQ + G FG + F CN GY L G +C + GS WS
Sbjct: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
Query: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210
P C ++ C PP+I NG E + + Y +VTY+C+ F++IGE +IYC
Sbjct: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
Query: 211 --GDNSVWSRAAPECK 224
D WS PEC+
Sbjct: 269 VNNDEGEWSGPPPECR 284
Score = 82.4 bits (202), Expect = 6e-16
Identities = 74/319 (23%), Positives = 130/319 (40%), Gaps = 25/319 (7%)
Query: 17 PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76
P LLL ++ L + D C PP + + + + + YKC++ + IP
Sbjct: 19 PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
Query: 77 HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134
IC + W + ++ C R E + Q + G + + C GY
Sbjct: 78 SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
Query: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193
E L +L + WS C+K C P +I+NG+ +F +++SC+
Sbjct: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
Query: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250
+ L G ++ +C G + WS PEC+ + C P + I G + Y+
Sbjct: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
Query: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC-----LKVLPPSSTKPPALSHSVS 302
+V + C+KGF + G +I C N+ W P P+C +PP+ KP ++ +
Sbjct: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTT 307
Query: 303 TSSTTKSPASSASGYPKPE 321
S T ++ + P +
Sbjct: 308 EVSPTSQKTTTKTTTPNAQ 326
>gi|10835143 decay accelerating factor for complement isoform 1
preproprotein [Homo sapiens]
Length = 381
Score = 107 bits (266), Expect = 2e-23
Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 13/196 (6%)
Query: 34 ACEEPPTFEAMELIGK--PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSD 91
+CE P + L + Y+ +G V+Y+C+ GY P L+ C +N W +
Sbjct: 97 SCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKW-STAV 155
Query: 92 DACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWS 151
+ C +++CP + NGQ + G FG + F CN GY L G +C + GS WS
Sbjct: 156 EFCKKKSCPNPGEIRNGQ-IDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWS 214
Query: 152 GKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC- 210
P C ++ C PP+I NG E + + Y +VTY+C+ F++IGE +IYC
Sbjct: 215 DPLPECREIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKG-----FTMIGEHSIYCT 268
Query: 211 --GDNSVWSRAAPECK 224
D WS PEC+
Sbjct: 269 VNNDEGEWSGPPPECR 284
Score = 82.4 bits (202), Expect = 6e-16
Identities = 74/319 (23%), Positives = 130/319 (40%), Gaps = 25/319 (7%)
Query: 17 PGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLAT 76
P LLL ++ L + D C PP + + + + + YKC++ + IP
Sbjct: 19 PRLLLLVLLCLPAVWGD-CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKD 77
Query: 77 HTICDRNHTWLPVSDDACYR--ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLI 134
IC + W + ++ C R E + Q + G + + C GY
Sbjct: 78 SVICLKGSQWSDI-EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRR- 135
Query: 135 GEEILYCELKGSVAI-WSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDP 193
E L +L + WS C+K C P +I+NG+ +F +++SC+
Sbjct: 136 -EPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGA--TISFSCNT 192
Query: 194 APGPDPFSLIGESTIYC---GDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKA 250
+ L G ++ +C G + WS PEC+ + C P + I G + Y+
Sbjct: 193 G-----YKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQ 247
Query: 251 TVMFECDKGFYLDGSDTIVCDSNS---TWDPPVPKC-----LKVLPPSSTKPPALSHSVS 302
+V + C+KGF + G +I C N+ W P P+C +PP+ KP ++ +
Sbjct: 248 SVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTT 307
Query: 303 TSSTTKSPASSASGYPKPE 321
S T ++ + P +
Sbjct: 308 EVSPTSQKTTTKTTTPNAQ 326
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 103 bits (256), Expect = 3e-22
Identities = 67/235 (28%), Positives = 101/235 (42%), Gaps = 23/235 (9%)
Query: 57 GERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT 116
G + C GY + C N W S+ C C DP+ + +G
Sbjct: 2642 GATAIFTCNTGYTLVGSHVRE--CLANGLWSG-SETRCLAGHCGS-PDPIVNGHISGDG- 2696
Query: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFS 176
+ + + + CN G+ L+G + C WSG+ P+C + C P N H F+
Sbjct: 2697 FSYRDTVVYQCNPGFRLVGTSVRICLQDHK---WSGQTPVCVPITCGHPG---NPAHGFT 2750
Query: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFP----- 231
F D V ++C+ + L G S C N WS P C+VV C P
Sbjct: 2751 NGSEFNLNDVVNFTCNTG-----YLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVEN 2805
Query: 232 VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
+ +G+Q F + F Y ++++ C KGFYL GS + C +N WD +PKCL +
Sbjct: 2806 AIRHGQQ--NFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAI 2858
Score = 99.4 bits (246), Expect = 5e-21
Identities = 72/247 (29%), Positives = 107/247 (43%), Gaps = 23/247 (9%)
Query: 58 ERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGT- 116
+ V Y+C G+ + + IC ++H W + C TC + +P +G NG+
Sbjct: 2701 DTVVYQCNPGFRLVG--TSVRICLQDHKWSGQTP-VCVPITCGHPGNPAHGFT---NGSE 2754
Query: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKN----GK 172
+ ++F CN GY L G C G WS P C V C+ P ++N G+
Sbjct: 2755 FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQ---WSSPLPTCRVVNCSDPGFVENAIRHGQ 2811
Query: 173 HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPV 232
F E FEY ++ Y C F L+G S + C N +W R+ P+C + C P
Sbjct: 2812 QNFPES--FEYGMSILYHCKKG-----FYLLGSSALTCMANGLWDRSLPKCLAISCGHPG 2864
Query: 233 VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSST 292
V ++ G+ F Y A V + C L G+DT VC +S W +P C P
Sbjct: 2865 VPANAVLT--GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCG 2922
Query: 293 KPPALSH 299
P +H
Sbjct: 2923 DPGTPAH 2929
Score = 97.1 bits (240), Expect = 2e-20
Identities = 71/243 (29%), Positives = 105/243 (43%), Gaps = 23/243 (9%)
Query: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
V Y C +GY + H C N TW + D C +C NG + + F
Sbjct: 3002 VIYACWEGYKTSGLMTRH--CTANGTWTGTAPD-CTIISCGDPGTLANG--IQFGTDFTF 3056
Query: 120 GYQMHFICNEGYYL--IGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSE 177
+ + CN GY + + + C G W+ P+C+ VLC PP ++NG S+
Sbjct: 3057 NKTVSYQCNPGYVMEAVTSATIRCTKDGR---WNPSKPVCKAVLCPQPPPVQNGTVEGSD 3113
Query: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGK 237
F + +++YSC D + L + + C VW P+C V C P +
Sbjct: 3114 ---FRWGSSISYSC-----MDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEG 3165
Query: 238 QISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKP-PA 296
++SG K F YK+ V F+C F L GS VC ++ TW P C+ P +T P P
Sbjct: 3166 RLSG--KSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCID--PAHNTCPDPG 3221
Query: 297 LSH 299
H
Sbjct: 3222 TPH 3224
Score = 89.0 bits (219), Expect = 6e-18
Identities = 69/251 (27%), Positives = 103/251 (41%), Gaps = 23/251 (9%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+ + V Y+C GY + C ++ W P S C CP NG +
Sbjct: 3054 FTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNP-SKPVCKAVLCPQPPPVQNGTVEGS 3112
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKH 173
+ + +G + + C +GY L IL CE +G +W G+ P C V C P G+
Sbjct: 3113 D--FRWGSSISYSCMDGYQLSHSAILSCEGRG---VWKGEIPQCLPVFCGDPGIPAEGRL 3167
Query: 174 TFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPEC---KVVKCRF 230
+ F Y V + C PF L+G S C + WS P C C
Sbjct: 3168 SGKS---FTYKSEVFFQCK-----SPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPD 3219
Query: 231 PVVEN-GKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
P + G Q S G + +TV F C KG+++ GS T C +N TW +C +P
Sbjct: 3220 PGTPHFGIQNSSRG--YEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTEC---IPH 3274
Query: 290 SSTKPPALSHS 300
+ +P +H+
Sbjct: 3275 ACRQPETPAHA 3285
Score = 74.3 bits (181), Expect = 2e-13
Identities = 68/244 (27%), Positives = 101/244 (41%), Gaps = 33/244 (13%)
Query: 56 IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA---CYRETCPYIRDPLNGQAVP 112
+G +V Y CK GY + ++ C RN + D C +C P NG
Sbjct: 2452 VGSKVHYFCKPGYRMVGH--SNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFT- 2508
Query: 113 ANGTYEFGYQMHFICNEGYYLIGEE--ILYCELKGSVAIWS--GKPPICEKVLCTPPPKI 168
+ ++ + C+EG+ L + C+ G +WS GKPP C+ V C P +
Sbjct: 2509 -GNEFTLDSKVVYECHEGFKLESSQQATAVCQEDG---LWSNKGKPPTCKPVAC-PSIEA 2563
Query: 169 KNGKHTFSEV---EVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA--APEC 223
+ +H + + EY V SC P + L G + C N W+ P C
Sbjct: 2564 QLSEHVIWRLVSGSLNEYGAQVLLSCSPG-----YYLEGWRLLRCQANGTWNIGDERPSC 2618
Query: 224 KVVKC---RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280
+V+ C FP NG +I G Y AT +F C+ G+ L GS C +N W
Sbjct: 2619 RVISCGSLSFP--PNGNKI---GTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSE 2673
Query: 281 PKCL 284
+CL
Sbjct: 2674 TRCL 2677
Score = 73.9 bits (180), Expect = 2e-13
Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 26/238 (10%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCP---YIRDPLN 107
+ + + V++ C GY + C N W LP C C ++ + +
Sbjct: 2755 FNLNDVVNFTCNTGYLLQG--VSRAQCRSNGQWSSPLPT----CRVVNCSDPGFVENAIR 2808
Query: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
++E+G + + C +G+YL+G L C G +W P C + C P
Sbjct: 2809 HGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANG---LWDRSLPKCLAISCGHPGV 2865
Query: 168 IKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVK 227
N T E+F Y V YSC + SLIG T C ++S WS A P C
Sbjct: 2866 PANAVLTG---ELFTYGAVVHYSCRGSE-----SLIGNDTRVCQEDSHWSGALPHCTGNN 2917
Query: 228 CRFPVVENGKQISG--FGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
F + G G G F K+ + F C+ G L GS C N +W P C
Sbjct: 2918 PGF-CGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVC 2974
Score = 71.6 bits (174), Expect = 1e-12
Identities = 62/234 (26%), Positives = 91/234 (38%), Gaps = 22/234 (9%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
+E G + Y CKKG++ + A C N W S C +C + P N AV
Sbjct: 2818 FEYGMSILYHCKKGFYLLGSSAL--TCMANGLW-DRSLPKCLAISCGHPGVPAN--AVLT 2872
Query: 114 NGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC---EKVLCTPPPKIKN 170
+ +G +H+ C LIG + C+ WSG P C C P +
Sbjct: 2873 GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSH---WSGALPHCTGNNPGFCGDPGTPAH 2929
Query: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
G + F+ + +SC+ L G C N WS P C+ V C
Sbjct: 2930 GSRLGDD---FKTKSLLRFSCEMG-----HQLRGSPERTCLLNGSWSGLQPVCEAVSCGN 2981
Query: 231 P-VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
P NG +S G + ++V++ C +G+ G T C +N TW P C
Sbjct: 2982 PGTPTNGMIVSSDG--ILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDC 3033
Score = 70.9 bits (172), Expect = 2e-12
Identities = 59/216 (27%), Positives = 86/216 (39%), Gaps = 28/216 (12%)
Query: 96 RETCPY--IRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKG-SVAIWSG 152
R PY + PL + G ++H+ C GY ++G C + W
Sbjct: 2427 RYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDS 2486
Query: 153 KPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIG--ESTIYC 210
P+C+ V C P NG T +E F V Y C + F L ++T C
Sbjct: 2487 LTPLCQAVSCGIPESPGNGSFTGNE---FTLDSKVVYECH-----EGFKLESSQQATAVC 2538
Query: 211 GDNSVWSRAA--PECKVVKCRFPVVENGKQISGF-------GKKFYYKATVMFECDKGFY 261
++ +WS P CK V C P +E Q+S G Y A V+ C G+Y
Sbjct: 2539 QEDGLWSNKGKPPTCKPVAC--PSIE--AQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYY 2594
Query: 262 LDGSDTIVCDSNSTWD--PPVPKCLKVLPPSSTKPP 295
L+G + C +N TW+ P C + S + PP
Sbjct: 2595 LEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPP 2630
Score = 51.2 bits (121), Expect = 1e-06
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 8/106 (7%)
Query: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
YE+G V ++C+KGY +I T T C N TW + + C C P + V A
Sbjct: 3234 YEVGSTVFFRCRKGY-HIQGSTTRT-CLANLTWSGIQTE-CIPHACRQPETPAHAD-VRA 3289
Query: 114 NGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPICE 158
FGY + + C+ G++L G E C+ W+GK P+C+
Sbjct: 3290 IDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMK---WTGKSPVCK 3332
Score = 47.8 bits (112), Expect = 2e-05
Identities = 56/243 (23%), Positives = 84/243 (34%), Gaps = 54/243 (22%)
Query: 93 ACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWS 151
A + CP P NG+ ++ + G + F C + Y L G + + C+ + ++A WS
Sbjct: 343 ALVSDMCPDPGIPENGRRAGSDFS-RVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWS 401
Query: 152 GKPPICEKVLC--------------------------------TPPPKIKNGKHTFSEVE 179
PIC C T P K+ K F E E
Sbjct: 402 DHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVI--KLAFEEFE 459
Query: 180 VFEYLDAVTYSCDPAPGPDP---FSLIGEST---IYCGDNSVWSRAAPECKV----VKCR 229
+ D +T G + L G S I N +W + + K
Sbjct: 460 LERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAV 519
Query: 230 FPVVENG----KQISGFGKK----FYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVP 281
+ +E G I +GK+ F + T+ FEC F L G I C N+ W P
Sbjct: 520 YQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKP 579
Query: 282 KCL 284
C+
Sbjct: 580 SCV 582
Score = 41.6 bits (96), Expect = 0.001
Identities = 33/112 (29%), Positives = 51/112 (45%), Gaps = 20/112 (17%)
Query: 225 VVKCRFPVVEN-GKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNS--TWDPPVP 281
+VKC P + N G +I G + V++ C+ G+ + GS+T+ C S WD P+P
Sbjct: 1215 LVKCEDPGIPNYGYRIRDEGH--FTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLP 1272
Query: 282 KCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLDVWVI 333
C+ + H+ +TS SP GYP P + L W+I
Sbjct: 1273 SCI-------AECGGQIHA-ATSGRILSP-----GYPAPYDNNLHC--TWII 1309
Score = 41.2 bits (95), Expect = 0.002
Identities = 52/233 (22%), Positives = 85/233 (36%), Gaps = 70/233 (30%)
Query: 111 VPANG-----TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC-------- 157
+PA G ++ G + F C + L+GE ++ C+ WSG P C
Sbjct: 533 IPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQ---WSGNKPSCVFSCFFNF 589
Query: 158 ---EKVLCTP--PPKIKNGKHT---------------FSEVEVFEYLDAVTYSCDPAPGP 197
++ +P P + N + F++ +V D + D G
Sbjct: 590 TASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDD---GI 646
Query: 198 DPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVEN---------------------G 236
+++G + N V S+ A +V+ F + G
Sbjct: 647 SDITVLGTFS----GNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPG 702
Query: 237 KQISG--FGKKFYYKATVMFECDKGFY-LDGSDTIVC---DSNSTWDPPVPKC 283
I+G FG +F ++V F CD GF GS++I C D N W VP+C
Sbjct: 703 IPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRC 755
Score = 40.4 bits (93), Expect = 0.003
Identities = 55/232 (23%), Positives = 83/232 (35%), Gaps = 61/232 (26%)
Query: 105 PLNGQAVPANGTYEFGYQMHFICNEGYYLI-GEEILYCELKGSVAIWSGKPPICEK---- 159
P+NG+ + G + F C++G+ G E + C L+ +WS P CE
Sbjct: 704 PINGRRF--GDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGG 761
Query: 160 -------VLCTP--PPKIKNGKH---------------TFSEVEVFEYLDAVTYSCDPAP 195
V+ P P K+ H TF + D + PA
Sbjct: 762 HLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPAS 821
Query: 196 GPDPFSLIGE-----------ST------IYCGDNSVWS------RAAPECKVVKCRFP- 231
LIGE ST ++ DNS S + + C P
Sbjct: 822 SS---PLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPG 878
Query: 232 VVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
+ NG + G F ++TV F CD G+ L + +VC+ N W+ +P C
Sbjct: 879 IPVNGHRHGG---DFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC 927
Score = 38.5 bits (88), Expect = 0.010
Identities = 53/233 (22%), Positives = 87/233 (37%), Gaps = 59/233 (25%)
Query: 107 NGQAVPANGTY-----EFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPIC---- 157
N +P NGT E G + F C+ GY L G+ + C + W PP C
Sbjct: 1393 NDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAAC 1452
Query: 158 -------EKVLCTP--PPKIKNGKHTFSEVEVF-EYLDAV---TYSCDPA-------PGP 197
V+ +P P GK V+V +++ A+ +++ +P+ G
Sbjct: 1453 GGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGE 1512
Query: 198 DPFS-LIGE-------STIYCGDNSVWSRAAPECKVVKCRFPV---------------VE 234
D S LIG I NS++ + V F + +
Sbjct: 1513 DSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIM 1572
Query: 235 NGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVC----DSNSTWDPPVPKC 283
NG ++ G F +T+ ++CD G+ + +I C D +WD +P C
Sbjct: 1573 NGTRV---GTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622
Score = 38.1 bits (87), Expect = 0.013
Identities = 27/73 (36%), Positives = 32/73 (43%), Gaps = 9/73 (12%)
Query: 158 EKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS 217
EK C P GK T S F + D +T+ C P F L+GE I C N+ WS
Sbjct: 524 EKGGCGDPGIPAYGKRTGSS---FLHGDTLTFEC-----PAAFELVGERVITCQQNNQWS 575
Query: 218 RAAPECKVVKCRF 230
P C V C F
Sbjct: 576 GNKPSC-VFSCFF 587
Score = 38.1 bits (87), Expect = 0.013
Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 24/123 (19%)
Query: 218 RAAPECKVVKCR-FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS---- 272
+A P +C P G++I G +F + V FEC+ G+ L GS + C S
Sbjct: 1732 QAVPRTSDTQCSSVPEPRYGRRI---GSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNA 1788
Query: 273 NSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLDVWV 332
+ W+ +P C+ P + T SP GYP+P L+ +W
Sbjct: 1789 LAQWNDTIPSCV---------VPCSGNFTQRRGTILSP-----GYPEPYGNNLNC--IWK 1832
Query: 333 IAV 335
I V
Sbjct: 1833 IIV 1835
Score = 34.3 bits (77), Expect = 0.19
Identities = 33/132 (25%), Positives = 55/132 (41%), Gaps = 18/132 (13%)
Query: 187 VTYSCDPAPGPDPFSLIGESTIYC--GDNSVWSRAAPECKVVKC--RFPVVENGKQIS-G 241
V YSC+P +++ G +T+ C GD VW + P C + +C + +G+ +S G
Sbjct: 1241 VLYSCNPG-----YAMHGSNTLTCLSGDRRVWDKPLPSC-IAECGGQIHAATSGRILSPG 1294
Query: 242 FGKKF--YYKATVMFECDKG-----FYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKP 294
+ + T + E D G ++ + D WD PV + + S +
Sbjct: 1295 YPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSAL 1354
Query: 295 PALSHSVSTSST 306
P HS S T
Sbjct: 1355 PEDIHSTFNSLT 1366
Score = 34.3 bits (77), Expect = 0.19
Identities = 16/47 (34%), Positives = 22/47 (46%), Gaps = 3/47 (6%)
Query: 251 TVMFECDKGFYLDGSDTIVC---DSNSTWDPPVPKCLKVLPPSSTKP 294
TV F+CD G+ L G I C ++ W P P C+ + T P
Sbjct: 1413 TVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGP 1459
Score = 33.1 bits (74), Expect = 0.42
Identities = 29/126 (23%), Positives = 52/126 (41%), Gaps = 18/126 (14%)
Query: 181 FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS 240
F VT+SCDP ++L + + C N W+ A P C + + ++G +S
Sbjct: 890 FGIRSTVTFSCDPG-----YTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLS 944
Query: 241 GFGKKFYYKA-----TVMFECDKG-------FYLDGS-DTIVCDSNSTWDPPVPKCLKVL 287
FY + T+ KG F+L+ S D ++ + ++ PV + +
Sbjct: 945 PGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSV 1004
Query: 288 PPSSTK 293
P + K
Sbjct: 1005 LPHTIK 1010
Score = 33.1 bits (74), Expect = 0.42
Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Query: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
+E G + + C+ GY L+G +IL C+L + + G P CE
Sbjct: 2277 FEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQ-FEGSLPTCE 2317
Score = 32.7 bits (73), Expect = 0.55
Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 3/60 (5%)
Query: 99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCE-LKGSVAIWSGKPPIC 157
C + +P G+ + + + G + F CN GY L G L+C+ + ++A W+ P C
Sbjct: 1742 CSSVPEPRYGRRIGSE--FSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799
Score = 32.3 bits (72), Expect = 0.72
Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 3/62 (4%)
Query: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
+ CP NG + N Y G + F C GY LIG +L C+ G W+ P
Sbjct: 2086 QNCPDPPPFQNGYMI--NSDYSVGQSVSFECYPGYILIGHPVLTCQ-HGINRNWNYPFPR 2142
Query: 157 CE 158
C+
Sbjct: 2143 CD 2144
Score = 32.3 bits (72), Expect = 0.72
Identities = 28/107 (26%), Positives = 42/107 (39%), Gaps = 21/107 (19%)
Query: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDS--NSTWDPPVPKCLKVLP 288
P +NG I+ + +V FEC G+ L G + C N W+ P P+C
Sbjct: 2092 PPFQNGYMINS---DYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRC----- 2143
Query: 289 PSSTKPPALSHSVSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAV 335
P + S + T SP G+P + D +W+I V
Sbjct: 2144 ----DAPCGYNVTSQNGTIYSP-----GFPDEYPILKDC--IWLITV 2179
Score = 29.6 bits (65), Expect = 4.7
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 6/63 (9%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYI--PPLATHTICDRNHTW-LPVSD 91
C +PP F+ +I Y +G+ V ++C GY I P L +RN + P D
Sbjct: 2088 CPDPPPFQNGYMINSD---YSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCD 2144
Query: 92 DAC 94
C
Sbjct: 2145 APC 2147
Score = 28.9 bits (63), Expect = 8.0
Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 9/77 (11%)
Query: 213 NSVWSRAAPECKVVKCRFP-VVENGKQI-SGFGKKFYYKATVMFECDKGFYLDGSDTIVC 270
NSV S+ C P + ENG++ S F + A V F C+ + L GS +I C
Sbjct: 334 NSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSR---VGANVQFSCEDNYVLQGSKSITC 390
Query: 271 ----DSNSTWDPPVPKC 283
++ + W P C
Sbjct: 391 QRVTETLAAWSDHRPIC 407
Score = 28.9 bits (63), Expect = 8.0
Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 6/49 (12%)
Query: 162 CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC 210
C PPP + + +E + FE D V Y C P ++L+G + C
Sbjct: 2259 CQPPPAVPQAE-MLTEDDDFEIGDFVKYQCHPG-----YTLVGTDILTC 2301
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 101 bits (251), Expect = 1e-21
Identities = 81/278 (29%), Positives = 123/278 (44%), Gaps = 31/278 (11%)
Query: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
Query: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
Query: 133 LIGEEILY--CELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAV 187
L+GE I Y C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 120 LLGE-INYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAV 174
Query: 188 TYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY 247
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K
Sbjct: 175 RFVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKII 226
Query: 248 YKATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
YK F+ C+ G+ VC + S W P+P C
Sbjct: 227 YKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
Score = 84.3 bits (207), Expect = 2e-16
Identities = 64/242 (26%), Positives = 101/242 (41%), Gaps = 22/242 (9%)
Query: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
Query: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
Query: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
Query: 264 GSDTIVCDSNSTWDPPVPKCLKV--LPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPE 321
G + + C + W PKC+++ P +S + + GY E
Sbjct: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSE 245
Query: 322 EG 323
G
Sbjct: 246 RG 247
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/266 (26%), Positives = 105/266 (39%), Gaps = 42/266 (15%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
Query: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
Query: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
Query: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
Query: 261 YLDGSDTIVCDSNSTWDPPVPKCLKV 286
L + T V + W P P+C++V
Sbjct: 421 ALPKAQTTVTCMENGWS-PTPRCIRV 445
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 101 bits (251), Expect = 1e-21
Identities = 81/278 (29%), Positives = 123/278 (44%), Gaps = 31/278 (11%)
Query: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
Query: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
Query: 133 LIGEEILY--CELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAV 187
L+GE I Y C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 120 LLGE-INYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAV 174
Query: 188 TYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFY 247
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K
Sbjct: 175 RFVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKII 226
Query: 248 YKATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
YK F+ C+ G+ VC + S W P+P C
Sbjct: 227 YKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
Score = 84.3 bits (207), Expect = 2e-16
Identities = 64/242 (26%), Positives = 101/242 (41%), Gaps = 22/242 (9%)
Query: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
Query: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
Query: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
Query: 264 GSDTIVCDSNSTWDPPVPKCLKV--LPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPE 321
G + + C + W PKC+++ P +S + + GY E
Sbjct: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSE 245
Query: 322 EG 323
G
Sbjct: 246 RG 247
Score = 72.0 bits (175), Expect = 8e-13
Identities = 62/242 (25%), Positives = 107/242 (44%), Gaps = 27/242 (11%)
Query: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
++++ + +DY+C GY T +I + W LP+ CY C + ++
Sbjct: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580
Query: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
Y+ G + F C G+ ++G + C G S PIC++ + C PPP++
Sbjct: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636
Query: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
NG E + + + V Y C+P F + G + I C D W+ P C V +
Sbjct: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689
Query: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
P +E+G Q+S +YY +V F C + F + G +I C + W +P+C+
Sbjct: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745
Query: 285 KV 286
+
Sbjct: 746 AI 747
Score = 71.6 bits (174), Expect = 1e-12
Identities = 60/240 (25%), Positives = 103/240 (42%), Gaps = 22/240 (9%)
Query: 49 KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
K K ++ + Y+C+ +I HT+C N W P V+ + CP N
Sbjct: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819
Query: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
+ Y G ++ +C E Y + E + C+ W P EK+ C+ PP+
Sbjct: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875
Query: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
I++G + S E + + ++Y+C+ G S E+T Y G WS + P+C+
Sbjct: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928
Query: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
+ C+ P + ++ + Y V ++C +GF +DG C W P P C+K
Sbjct: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986
Score = 68.2 bits (165), Expect = 1e-11
Identities = 68/287 (23%), Positives = 116/287 (40%), Gaps = 31/287 (10%)
Query: 35 CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
C +PP E + + Y G ++ Y C+ G+ I + N T +
Sbjct: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920
Query: 90 -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
S C C + +G + +Y++G ++ + C EG+ + G I C +
Sbjct: 921 SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
Query: 149 IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
WS PP C K C P +N + +V++ + VTY+C + + G S +
Sbjct: 978 -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030
Query: 209 YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
C NS W+ P C+ C P V+N +S K+ V ++C + + G +
Sbjct: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
Query: 268 IVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSV-STSSTTKSPASS 313
++C N W P P+C PP + + S + +PASS
Sbjct: 1089 VMC-LNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASS 1133
Score = 62.4 bits (150), Expect = 6e-10
Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)
Query: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
C P+FE +G+ K Y+ GE+V Y C +Y A++ C N W C
Sbjct: 989 CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043
Query: 95 YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
+C N V Y G ++ + C Y + G+E + C L G+ W+ +
Sbjct: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098
Query: 154 PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
PP C+ C PPP I NG T + V+ +V Y C + + L G I C
Sbjct: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152
Query: 212 DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
N WS KC P V + + + + +K Y + +V F C +G+
Sbjct: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206
Query: 262 LDG-SDTIVCDSNSTWDPPV--PKCLK 285
L S T+ + WD + P C K
Sbjct: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230
Score = 61.2 bits (147), Expect = 1e-09
Identities = 74/287 (25%), Positives = 112/287 (39%), Gaps = 42/287 (14%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
Query: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
Query: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
Query: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
Query: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
L + T V + W P P+C++V S + + +S S T
Sbjct: 421 ALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISESQYT 466
Score = 55.8 bits (133), Expect = 6e-08
Identities = 68/281 (24%), Positives = 129/281 (45%), Gaps = 37/281 (13%)
Query: 37 EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
E P + + + K Y++GE + + CK G+ + P + LP+ +
Sbjct: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627
Query: 97 ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
++C + LNG V E+G+ + + CN + + G + C + G W+ P
Sbjct: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682
Query: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
I E+ C P++++G S + Y D+V ++C + F++IG +I C +
Sbjct: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735
Query: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
VW++ P+C K+ KC+ + ++ K+F + + + + C +G +G V
Sbjct: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791
Query: 270 CDSNSTWDPPVPKC----LKVLPPSSTKPPAL--SHSVSTS 304
C N WDP V C +++ PP PP + SH+++T+
Sbjct: 792 C-INGRWDPEV-NCSMAQIQLCPP----PPQIPNSHNMTTT 826
Score = 32.0 bits (71), Expect = 0.94
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
+C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,338,052
Number of Sequences: 37866
Number of extensions: 1057506
Number of successful extensions: 5467
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 3675
Number of HSP's gapped (non-prelim): 804
length of query: 378
length of database: 18,247,518
effective HSP length: 104
effective length of query: 274
effective length of database: 14,309,454
effective search space: 3920790396
effective search space used: 3920790396
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.