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Search of human proteins with 27262638
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27262638 sperm associated antigen 1 [Homo sapiens]
(926 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27262638 sperm associated antigen 1 [Homo sapiens] 1859 0.0
gi|27262636 sperm associated antigen 1 [Homo sapiens] 1859 0.0
gi|21361356 translocase of outer mitochondrial membrane 34 [Homo... 270 5e-72
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 117 5e-26
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H... 114 5e-25
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H... 109 1e-23
gi|225735595 RNA polymerase II associated protein 3 isoform 3 [H... 99 1e-20
gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens] 89 1e-17
gi|54607135 translocase of outer mitochondrial membrane 70 homol... 89 2e-17
gi|17149853 WAF-1/CIP1 stabilizing protein 39 [Homo sapiens] 80 7e-15
gi|19923193 heat shock 70kD protein binding protein [Homo sapiens] 75 3e-13
gi|4503729 FK506 binding protein 52 [Homo sapiens] 75 4e-13
gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens] 72 2e-12
gi|89179321 smooth muscle cell associated protein-1 isoform 3 [H... 70 7e-12
gi|29725607 smooth muscle cell associated protein-1 isoform 2 [H... 70 7e-12
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-... 70 7e-12
gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Hom... 70 1e-11
gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens] 70 1e-11
gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens] 69 2e-11
gi|224809329 FK506 binding protein 5 isoform 1 [Homo sapiens] 67 6e-11
gi|224809327 FK506 binding protein 5 isoform 1 [Homo sapiens] 67 6e-11
gi|4758384 FK506 binding protein 5 isoform 1 [Homo sapiens] 67 6e-11
gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 67 6e-11
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 66 1e-10
gi|52630440 FK506-binding protein 8 [Homo sapiens] 66 2e-10
gi|56181387 STIP1 homology and U-box containing protein 1 [Homo ... 64 5e-10
gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens] 64 5e-10
gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens] 64 5e-10
gi|156627581 tetratricopeptide repeat domain 4 [Homo sapiens] 63 1e-09
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 62 2e-09
>gi|27262638 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 1859 bits (4816), Expect = 0.0
Identities = 926/926 (100%), Positives = 926/926 (100%)
Query: 1 MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEF 60
MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEF
Sbjct: 1 MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEF 60
Query: 61 CEKHLQALAPESRALRKDKPAATAASFTAEEWEKIDGDIKSWVSEIKKEEDKMHFHETET 120
CEKHLQALAPESRALRKDKPAATAASFTAEEWEKIDGDIKSWVSEIKKEEDKMHFHETET
Sbjct: 61 CEKHLQALAPESRALRKDKPAATAASFTAEEWEKIDGDIKSWVSEIKKEEDKMHFHETET 120
Query: 121 FPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK 180
FPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK
Sbjct: 121 FPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK 180
Query: 181 TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP 240
TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP
Sbjct: 181 TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP 240
Query: 241 TVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLS 300
TVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLS
Sbjct: 241 TVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLS 300
Query: 301 KVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED 360
KVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED
Sbjct: 301 KVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED 360
Query: 361 GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPR 420
GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPR
Sbjct: 361 GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPR 420
Query: 421 RASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGS 480
RASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGS
Sbjct: 421 RASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGS 480
Query: 481 EIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA 540
EIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA
Sbjct: 481 EIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA 540
Query: 541 YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKE 600
YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKE
Sbjct: 541 YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKE 600
Query: 601 MISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIY 660
MISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIY
Sbjct: 601 MISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIY 660
Query: 661 TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL 720
TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL
Sbjct: 661 TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL 720
Query: 721 DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCL 780
DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCL
Sbjct: 721 DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCL 780
Query: 781 ASEKGGKSSRSPEDPEKLPIAKPNNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMF 840
ASEKGGKSSRSPEDPEKLPIAKPNNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMF
Sbjct: 781 ASEKGGKSSRSPEDPEKLPIAKPNNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMF 840
Query: 841 LSNKLEGDTFLLLIQSLKNNLIEKDPSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQL 900
LSNKLEGDTFLLLIQSLKNNLIEKDPSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQL
Sbjct: 841 LSNKLEGDTFLLLIQSLKNNLIEKDPSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQL 900
Query: 901 FEDLSDTPNNHFTLEDIQALKRQYEL 926
FEDLSDTPNNHFTLEDIQALKRQYEL
Sbjct: 901 FEDLSDTPNNHFTLEDIQALKRQYEL 926
>gi|27262636 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 1859 bits (4816), Expect = 0.0
Identities = 926/926 (100%), Positives = 926/926 (100%)
Query: 1 MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEF 60
MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEF
Sbjct: 1 MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEF 60
Query: 61 CEKHLQALAPESRALRKDKPAATAASFTAEEWEKIDGDIKSWVSEIKKEEDKMHFHETET 120
CEKHLQALAPESRALRKDKPAATAASFTAEEWEKIDGDIKSWVSEIKKEEDKMHFHETET
Sbjct: 61 CEKHLQALAPESRALRKDKPAATAASFTAEEWEKIDGDIKSWVSEIKKEEDKMHFHETET 120
Query: 121 FPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK 180
FPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK
Sbjct: 121 FPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEK 180
Query: 181 TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP 240
TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP
Sbjct: 181 TVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP 240
Query: 241 TVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLS 300
TVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLS
Sbjct: 241 TVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLS 300
Query: 301 KVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED 360
KVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED
Sbjct: 301 KVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHED 360
Query: 361 GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPR 420
GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPR
Sbjct: 361 GGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPR 420
Query: 421 RASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGS 480
RASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGS
Sbjct: 421 RASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGS 480
Query: 481 EIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA 540
EIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA
Sbjct: 481 EIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA 540
Query: 541 YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKE 600
YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKE
Sbjct: 541 YVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKE 600
Query: 601 MISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIY 660
MISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIY
Sbjct: 601 MISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIY 660
Query: 661 TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL 720
TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL
Sbjct: 661 TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL 720
Query: 721 DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCL 780
DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCL
Sbjct: 721 DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCL 780
Query: 781 ASEKGGKSSRSPEDPEKLPIAKPNNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMF 840
ASEKGGKSSRSPEDPEKLPIAKPNNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMF
Sbjct: 781 ASEKGGKSSRSPEDPEKLPIAKPNNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMF 840
Query: 841 LSNKLEGDTFLLLIQSLKNNLIEKDPSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQL 900
LSNKLEGDTFLLLIQSLKNNLIEKDPSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQL
Sbjct: 841 LSNKLEGDTFLLLIQSLKNNLIEKDPSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQL 900
Query: 901 FEDLSDTPNNHFTLEDIQALKRQYEL 926
FEDLSDTPNNHFTLEDIQALKRQYEL
Sbjct: 901 FEDLSDTPNNHFTLEDIQALKRQYEL 926
>gi|21361356 translocase of outer mitochondrial membrane 34 [Homo
sapiens]
Length = 309
Score = 270 bits (690), Expect = 5e-72
Identities = 145/299 (48%), Positives = 199/299 (66%), Gaps = 8/299 (2%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
L++ GNE FR+GQ+AEA+ Y A+ +L+ GS ++ S+LYSNRAAC+LK+GNC CI
Sbjct: 12 LRAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDGNCRDCI 71
Query: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRI 567
+DC AL L PFS+KPLLRRA AYE LE+Y AYVDYKTVLQID + A + +NR++R
Sbjct: 72 KDCTSALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGINRMTRA 131
Query: 568 LMELDGPNWREKLSPIPAVPASVPLQAWHPA-----KEMISKQAGDSSS--HRQQGITDE 620
LM+ GP WR KL IP VP S + W+ KEM ++ ++++ +R D
Sbjct: 132 LMDSLGPEWRLKLPSIPLVPVSAQ-KRWNSLPSENHKEMAKSKSKETTATKNRVPSAGDV 190
Query: 621 KTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDC 680
+ + LKEEGN+ V N+K A+ KYSE L +N E A Y+NRALCYL L Q+ EA +DC
Sbjct: 191 EKARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDC 250
Query: 681 DQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLN 739
+AL+L NVKAFYRRA AHK LK+Y+ S D++ ++ ++P A+ +EV + L+
Sbjct: 251 TEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIEPRNGPAQKLRQEVKQNLH 309
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/150 (31%), Positives = 80/150 (53%), Gaps = 6/150 (4%)
Query: 175 EDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTR 234
E++KE + + R+ +AG EK + KE+GNE G++++A+ Y+
Sbjct: 164 ENHKEMAKSKSKETTATKNRVPSAGDVEKARVL-----KEEGNELVKKGNHKKAIEKYSE 218
Query: 235 SISALPTVVA-YNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLR 293
S+ A Y+NRA + L+ + A +DC + L+L+ NVKA RRA +K +
Sbjct: 219 SLLCSNLESATYSNRALCYLVLKQYTEAVKDCTEALKLDGKNVKAFYRRAQAHKALKDYK 278
Query: 294 EATEDLSKVLDVEPDNDLAKKTLSEVERDL 323
+ D+S +L +EP N A+K EV+++L
Sbjct: 279 SSFADISNLLQIEPRNGPAQKLRQEVKQNL 308
Score = 63.9 bits (154), Expect = 6e-10
Identities = 51/196 (26%), Positives = 82/196 (41%), Gaps = 13/196 (6%)
Query: 216 GNEAFNSGDYEEAVMYYTRSISALPTV---------VAYNNRAQAEIKLQNWNSAFQDCE 266
GNE+F +G Y EA Y R++ L V Y+NRA +K N +DC
Sbjct: 16 GNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDGNCRDCIKDCT 75
Query: 267 KVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNS 326
L L P ++K LLRRA+ Y+ K A D VL ++ + A + ++ + R L +S
Sbjct: 76 SALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGINRMTRALMDS 135
Query: 327 EAASETQTKGKRMVIQEIENSEDEEGKSGRKHEDGGGDKKPAEPAGAARAAQPCVMGNIQ 386
E + K + + + + H++ K A R G+++
Sbjct: 136 -LGPEWRLKLPSIPLVPVSAQKRWNSLPSENHKEMAKSKSKETTATKNRVPS---AGDVE 191
Query: 387 KKLTGKAEGGKRPARG 402
K K EG + +G
Sbjct: 192 KARVLKEEGNELVKKG 207
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 117 bits (293), Expect = 5e-26
Identities = 122/533 (22%), Positives = 220/533 (41%), Gaps = 94/533 (17%)
Query: 213 KEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQAEIKLQNWNSAFQDCEKVLEL 271
KEKGN+A + G+ ++A+ Y+ +I P V Y+NR+ A K ++ A++D K ++L
Sbjct: 8 KEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDL 67
Query: 272 EPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDL-------- 323
+P K R+A + N+ EA + L E +N K+ L +E L
Sbjct: 68 KPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNP 127
Query: 324 -------KNSEAASETQTKGKRMVIQE-IENSEDEEGKSGRKHEDGGGDKKPAEPAGAAR 375
+ E+ T+T +E IE ++ G K +D
Sbjct: 128 FNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDP-----------RIM 176
Query: 376 AAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGH 435
++G + + E P P++ PE + + A
Sbjct: 177 TTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKE-------- 228
Query: 436 PGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILY-SNRA 494
K GN+ ++ F A Y A L D ++ Y +N+A
Sbjct: 229 -------------KELGNDAYKKKDFDTALKHYDKAKEL---------DPTNMTYITNQA 266
Query: 495 ACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGL 554
A Y ++G+ + C + C +A+E+ + + + A AY + G +Y +
Sbjct: 267 AVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARI---GNSYFKEEKY------- 316
Query: 555 QLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQ 614
D+++ ++ L E P+ +K A++++ +Q R
Sbjct: 317 ---KDAIHFYNKSLAEHRTPDVLKKCQQ---------------AEKILKEQ------ERL 352
Query: 615 QGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFE 674
I + + K +GN+C +Y A+ Y+E +K N K+ +Y+NRA CY KL +F+
Sbjct: 353 AYINPDLALEE-KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQ 411
Query: 675 EAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEA 727
A +DC++ +QL +K + R+A A + +K+Y K++ K + LD S EA
Sbjct: 412 LALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEA 464
Score = 70.9 bits (172), Expect = 5e-12
Identities = 37/100 (37%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 208 LATREKEKGNEAFNSGDYEEAVMYYTRSISALPT-VVAYNNRAQAEIKLQNWNSAFQDCE 266
LA EK KGNE F GDY +A+ +YT +I P Y+NRA KL + A +DCE
Sbjct: 359 LALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCE 418
Query: 267 KVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVE 306
+ ++LEP +K R+A + +A + K LD++
Sbjct: 419 ECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD 458
Score = 64.7 bits (156), Expect = 4e-10
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 8/115 (6%)
Query: 449 KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQ 508
K++GNE F+ G + +A Y+ AI P ++ LYSNRAACY K ++
Sbjct: 364 KNKGNECFQKGDYPQAMKHYTEAIKR-NPKDAK-------LYSNRAACYTKLLEFQLALK 415
Query: 509 DCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNR 563
DC ++L P +K R+A A E ++ Y KA Y+ L +D + A D R
Sbjct: 416 DCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQR 470
Score = 62.8 bits (151), Expect = 1e-09
Identities = 77/377 (20%), Positives = 149/377 (39%), Gaps = 72/377 (19%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
LK +GN+ G +A YS AI L +P +LYSNR+A Y K+G+
Sbjct: 7 LKEKGNKALSVGNIDDALQCYSEAIKL-DPHNH-------VLYSNRSAAYAKKGDYQKAY 58
Query: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRI 567
+D + ++L P K R+A A E L ++ +A Y+ L+ + + + +
Sbjct: 59 EDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEAR 118
Query: 568 LME------LDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQ------ 615
L E + PN +KL P + + E + + D + Q
Sbjct: 119 LAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTT 178
Query: 616 ---------GITDEK----------------------------TFKALKEE--GNQCVND 636
G DE+ +ALKE+ GN
Sbjct: 179 LSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKK 238
Query: 637 KNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYR 696
K++ AL Y + +++ TN+A Y + + + ++ C++A+++ N + + +
Sbjct: 239 KDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQ 298
Query: 697 RALAHKGLKN-------YQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNK 749
A A+ + N Y+ ++ NK L + + + ++ ++L +++ A N
Sbjct: 299 IAKAYARIGNSYFKEEKYKDAIHFYNK-SLAEHRTPDVLKKCQQAEKILKEQERLAYINP 357
Query: 750 EKERRKIEIQEVNEGKE 766
+ + ++E N+G E
Sbjct: 358 D-----LALEEKNKGNE 369
Score = 52.0 bits (123), Expect = 3e-06
Identities = 45/152 (29%), Positives = 71/152 (46%), Gaps = 17/152 (11%)
Query: 200 LTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAY-NNRAQAEIKLQNW 258
L E +K A +EKE GN+A+ D++ A+ +Y ++ PT + Y N+A + ++
Sbjct: 218 LPENKKQ--ALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDY 275
Query: 259 NSAFQDCEKVLELEPGN-------VKALLRRATTYKHQNKLREATEDLSKVL------DV 305
N + CEK +E+ N KA R +Y + K ++A +K L DV
Sbjct: 276 NKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDV 335
Query: 306 EPDNDLAKKTLSEVER-DLKNSEAASETQTKG 336
A+K L E ER N + A E + KG
Sbjct: 336 LKKCQQAEKILKEQERLAYINPDLALEEKNKG 367
>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
sapiens]
Length = 631
Score = 114 bits (284), Expect = 5e-25
Identities = 133/607 (21%), Positives = 245/607 (40%), Gaps = 93/607 (15%)
Query: 379 PCVMGNIQKKLTGKAEGGKRPARGAPQRGQTP----EAGA--------DKRSPRRASAAA 426
P GN +KK GKA+ + R + + EA A D+ ++ +
Sbjct: 55 PIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHES 114
Query: 427 AAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDL 486
+ + G ++ LK +GN+ F+ G++ EA Y+ G +
Sbjct: 115 LSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTK--------GMDADPYN 166
Query: 487 SILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKT 546
+L +NRA+ Y + + DCN A+ L+ K RR A L++ +A DY+
Sbjct: 167 PVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYER 226
Query: 547 VLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQA 606
VL+++ A + + ++S+ L + +E A + +++ ++ I Q
Sbjct: 227 VLELEPNNFEATNELRKISQALASKENSYPKE---------ADIVIKSTEGERKQIEAQ- 276
Query: 607 GDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALC 666
++QQ I++ K+ GN + Y+ A+ Y+ + + + NRA+
Sbjct: 277 ----QNKQQAISE-------KDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMA 325
Query: 667 YLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIE 726
YLK+ ++EEA++DC QA+ L KAF RR A L ++ D V+LL+P +
Sbjct: 326 YLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQ 385
Query: 727 AKMELEEVTR----------------LLNLKDKT---APFNKEKERRKIEIQEVNEGKEE 767
A EL ++ + +++ D T AP N + K+
Sbjct: 386 AVTELSKIKKKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKN 445
Query: 768 PGR----PAGEVSMGCL--ASEKGGKSSRSPED----------PEKLPIAKPNNAYEFGQ 811
+ P + + E SS P+ EK+PI +F
Sbjct: 446 SSQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFAT 505
Query: 812 II------NALSTRKD-------KEACAHLLAITAPKDLPMFLSNKLEGDTFLLLIQSLK 858
+ N+ D + L P P L+ D F +++ L
Sbjct: 506 TVLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILH 565
Query: 859 NNLIEKD-PSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQLFEDLSDTPNNHFTLEDI 917
+ IEK+ P L+++ L LS+ +RF M + +S+ +K++ LF + + ++E+
Sbjct: 566 DFYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEE- 624
Query: 918 QALKRQY 924
LK++Y
Sbjct: 625 --LKKRY 629
Score = 102 bits (255), Expect = 1e-21
Identities = 82/284 (28%), Positives = 134/284 (47%), Gaps = 29/284 (10%)
Query: 89 AEEWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSN-SCLHVGKEKYSK 147
AEE + D+++W +IK+++ M P ++NLPP+R N GK K S
Sbjct: 18 AEELQDFMRDLENWEKDIKQKD--MELRRQNGVP--EENLPPIRNGNFRKKKKGKAKESS 73
Query: 148 RPTKKKTPR------DYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLS-KIETRIDTAGL 200
+ T+++ + DY W K DV++ ++D+D D +H S E+ + G+
Sbjct: 74 KKTREENTKNRIKSYDYEAWAKLDVDRILDELDKD-------DSTHESLSQESESEEDGI 126
Query: 201 TEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQAEIKLQNWN 259
+ L KEKGN+ F G Y+EA+ YT+ + A P V NRA A +L+ +
Sbjct: 127 HVDSQKALVL--KEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFA 184
Query: 260 SAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEV 319
A DC + L KA RR KL EA +D +VL++EP+N A L ++
Sbjct: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244
Query: 320 ERDLKNSEAASETQ-------TKGKRMVIQEIENSEDEEGKSGR 356
+ L + E + + T+G+R I+ +N + + R
Sbjct: 245 SQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDR 288
Score = 74.3 bits (181), Expect = 5e-13
Identities = 51/165 (30%), Positives = 80/165 (48%), Gaps = 3/165 (1%)
Query: 160 EWDKFDVEKECLKIDEDY--KEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGN 217
E + F+ E KI + KE + ++ + T + + ++ A EK++GN
Sbjct: 231 EPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGN 290
Query: 218 EAFNSGDYEEAVMYYTRSISAL-PTVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNV 276
F G YE A+ YTR I+A + NRA A +K+Q + A +DC + + L+
Sbjct: 291 GFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYS 350
Query: 277 KALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVER 321
KA RR T KL EA +D VL +EP N A LS++++
Sbjct: 351 KAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKK 395
>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
sapiens]
Length = 665
Score = 109 bits (273), Expect = 1e-23
Identities = 117/499 (23%), Positives = 209/499 (41%), Gaps = 47/499 (9%)
Query: 379 PCVMGNIQKKLTGKAEGGKRPARGAPQRGQTP----EAGA--------DKRSPRRASAAA 426
P GN +KK GKA+ + R + + EA A D+ ++ +
Sbjct: 55 PIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHES 114
Query: 427 AAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDL 486
+ + G ++ LK +GN+ F+ G++ EA Y+ G +
Sbjct: 115 LSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTK--------GMDADPYN 166
Query: 487 SILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKT 546
+L +NRA+ Y + + DCN A+ L+ K RR A L++ +A DY+
Sbjct: 167 PVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYER 226
Query: 547 VLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQA 606
VL+++ A + + ++S+ L + +E A + +++ ++ I Q
Sbjct: 227 VLELEPNNFEATNELRKISQALASKENSYPKE---------ADIVIKSTEGERKQIEAQ- 276
Query: 607 GDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALC 666
++QQ I++ K+ GN + Y+ A+ Y+ + + + NRA+
Sbjct: 277 ----QNKQQAISE-------KDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMA 325
Query: 667 YLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIE 726
YLK+ ++EEA++DC QA+ L KAF RR A L ++ D V+LL+P +
Sbjct: 326 YLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQ 385
Query: 727 AKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGG 786
A EL ++ + L K + +R Q V + + P P + + E+ G
Sbjct: 386 AVTELSKIKKELIEKGHWDDVFLDSTQR----QNVVKPIDNPPHPGSTKPLKKVIIEETG 441
Query: 787 KSSRSPEDPEKLPIAKP-NNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMFLSNKL 845
++ + P+ A P NN +I A T K + L T+ L +
Sbjct: 442 NLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEE 501
Query: 846 EGDTFLLLIQ-SLKNNLIE 863
DT L Q SLK ++ +
Sbjct: 502 VSDTSSLQPQASLKQDVCQ 520
Score = 102 bits (255), Expect = 1e-21
Identities = 82/284 (28%), Positives = 134/284 (47%), Gaps = 29/284 (10%)
Query: 89 AEEWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSN-SCLHVGKEKYSK 147
AEE + D+++W +IK+++ M P ++NLPP+R N GK K S
Sbjct: 18 AEELQDFMRDLENWEKDIKQKD--MELRRQNGVP--EENLPPIRNGNFRKKKKGKAKESS 73
Query: 148 RPTKKKTPR------DYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLS-KIETRIDTAGL 200
+ T+++ + DY W K DV++ ++D+D D +H S E+ + G+
Sbjct: 74 KKTREENTKNRIKSYDYEAWAKLDVDRILDELDKD-------DSTHESLSQESESEEDGI 126
Query: 201 TEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQAEIKLQNWN 259
+ L KEKGN+ F G Y+EA+ YT+ + A P V NRA A +L+ +
Sbjct: 127 HVDSQKALVL--KEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFA 184
Query: 260 SAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEV 319
A DC + L KA RR KL EA +D +VL++EP+N A L ++
Sbjct: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244
Query: 320 ERDLKNSEAASETQ-------TKGKRMVIQEIENSEDEEGKSGR 356
+ L + E + + T+G+R I+ +N + + R
Sbjct: 245 SQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDR 288
Score = 76.6 bits (187), Expect = 1e-13
Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 3/167 (1%)
Query: 160 EWDKFDVEKECLKIDEDY--KEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGN 217
E + F+ E KI + KE + ++ + T + + ++ A EK++GN
Sbjct: 231 EPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGN 290
Query: 218 EAFNSGDYEEAVMYYTRSISAL-PTVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNV 276
F G YE A+ YTR I+A + NRA A +K+Q + A +DC + + L+
Sbjct: 291 GFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYS 350
Query: 277 KALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDL 323
KA RR T KL EA +D VL +EP N A LS+++++L
Sbjct: 351 KAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 397
>gi|225735595 RNA polymerase II associated protein 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 99.4 bits (246), Expect = 1e-20
Identities = 93/378 (24%), Positives = 165/378 (43%), Gaps = 27/378 (7%)
Query: 488 ILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTV 547
+L +NRA+ Y + + DCN A+ L+ K RR A L++ +A DY+ V
Sbjct: 9 VLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERV 68
Query: 548 LQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAG 607
L+++ A + + ++S+ L + +E A + +++ ++ I Q
Sbjct: 69 LELEPNNFEATNELRKISQALASKENSYPKE---------ADIVIKSTEGERKQIEAQ-- 117
Query: 608 DSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCY 667
++QQ I++ K+ GN + Y+ A+ Y+ + + + NRA+ Y
Sbjct: 118 ---QNKQQAISE-------KDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAY 167
Query: 668 LKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEA 727
LK+ ++EEA++DC QA+ L KAF RR A L ++ D V+LL+P +A
Sbjct: 168 LKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQA 227
Query: 728 KMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGGK 787
EL ++ + L K + +R Q V + + P P + + E+ G
Sbjct: 228 VTELSKIKKELIEKGHWDDVFLDSTQR----QNVVKPIDNPPHPGSTKPLKKVIIEETGN 283
Query: 788 SSRSPEDPEKLPIAKP-NNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMFLSNKLE 846
++ + P+ A P NN +I A T K + L T+ L +
Sbjct: 284 LIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEEV 343
Query: 847 GDTFLLLIQ-SLKNNLIE 863
DT L Q SLK ++ +
Sbjct: 344 SDTSSLQPQASLKQDVCQ 361
Score = 76.6 bits (187), Expect = 1e-13
Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 3/167 (1%)
Query: 160 EWDKFDVEKECLKIDEDY--KEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGN 217
E + F+ E KI + KE + ++ + T + + ++ A EK++GN
Sbjct: 72 EPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGN 131
Query: 218 EAFNSGDYEEAVMYYTRSISAL-PTVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNV 276
F G YE A+ YTR I+A + NRA A +K+Q + A +DC + + L+
Sbjct: 132 GFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYS 191
Query: 277 KALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDL 323
KA RR T KL EA +D VL +EP N A LS+++++L
Sbjct: 192 KAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 238
Score = 53.1 bits (126), Expect = 1e-06
Identities = 52/208 (25%), Positives = 87/208 (41%), Gaps = 25/208 (12%)
Query: 412 AGADKRSPRRASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAA 471
A + P+ A + G Q + K +GN F+ G++ A Y+
Sbjct: 90 ASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRG 149
Query: 472 IALLEPAGSEIADDLS-ILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMA 530
IA AD + +L +NRA YLK +DC +A+ L K RR A
Sbjct: 150 IA---------ADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTA 200
Query: 531 YETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRILME--------LDGPNWREKLSP 582
L + +A D++TVL ++ G + A ++++ + L+E LD + + P
Sbjct: 201 RTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKP 260
Query: 583 I--PAVPASVPLQAWHPAKEMISKQAGD 608
I P P S P K++I ++ G+
Sbjct: 261 IDNPPHPGST-----KPLKKVIIEETGN 283
Score = 48.9 bits (115), Expect = 2e-05
Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 7/117 (5%)
Query: 247 NRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVE 306
NRA A +L+ + A DC + L KA RR KL EA +D +VL++E
Sbjct: 13 NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 72
Query: 307 PDNDLAKKTLSEVERDLKNSEAASETQ-------TKGKRMVIQEIENSEDEEGKSGR 356
P+N A L ++ + L + E + + T+G+R I+ +N + + R
Sbjct: 73 PNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDR 129
Score = 38.1 bits (87), Expect = 0.038
Identities = 41/138 (29%), Positives = 58/138 (42%), Gaps = 23/138 (16%)
Query: 244 AYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVL 303
AY+ R A LQ A +D E+VLELEP N +A N+LR+ ++ L+
Sbjct: 44 AYSRRGAARFALQKLEEAKKDYERVLELEPNNFEA----------TNELRKISQALASKE 93
Query: 304 DVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHE---- 359
+ P A + E + K EA Q K + + ++ N +EGK R E
Sbjct: 94 NSYPKE--ADIVIKSTEGERKQIEA---QQNKQQAISEKDRGNGFFKEGKYERAIECYTR 148
Query: 360 ----DGGGDKKPAEPAGA 373
DG PA A A
Sbjct: 149 GIAADGANALLPANRAMA 166
>gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens]
Length = 292
Score = 89.4 bits (220), Expect = 1e-17
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 24/212 (11%)
Query: 132 RGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKI 191
+G C H + + P K K +ED +D+ +L ++
Sbjct: 57 QGEEECFHDCSASFEEEPGADKVEN---------------KSNEDVNSSE-LDEEYLIEL 100
Query: 192 ETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTV------VAY 245
E + ++ ++ +TR KE+GNE F GDY EA Y+R++ P+ + +
Sbjct: 101 EKNMSDEEKQKRREE--STRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILF 158
Query: 246 NNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDV 305
+NRA A +K A DC K ++L P ++A+LRRA Y+ +KL EA ED +L+
Sbjct: 159 SNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEK 218
Query: 306 EPDNDLAKKTLSEVERDLKNSEAASETQTKGK 337
+P A++ + + ++ + + GK
Sbjct: 219 DPSIHQAREACMRLPKQIEERNERLKEEMLGK 250
Score = 84.3 bits (207), Expect = 5e-16
Identities = 47/128 (36%), Positives = 73/128 (57%), Gaps = 3/128 (2%)
Query: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGN 502
E LK +GNE F+ G + EA YS A LE S + SIL+SNRAA +K+
Sbjct: 114 EESTRLKEEGNEQFKKGDYIEAESSYSRA---LEMCPSCFQKERSILFSNRAAARMKQDK 170
Query: 503 CSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVN 562
I DC++A++L+P ++ +LRRA YE ++ +A DYK++L+ D + A ++
Sbjct: 171 KEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACM 230
Query: 563 RLSRILME 570
RL + + E
Sbjct: 231 RLPKQIEE 238
Score = 58.2 bits (139), Expect = 4e-08
Identities = 39/135 (28%), Positives = 68/135 (50%), Gaps = 7/135 (5%)
Query: 599 KEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKI-----N 653
+E + + + S +Q +E T LKEEGN+ +Y +A S YS L++
Sbjct: 94 EEYLIELEKNMSDEEKQKRREEST--RLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQ 151
Query: 654 NKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLID 713
+ +++NRA +K + E A DC +A+QL ++A RRA ++ ++L D
Sbjct: 152 KERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALED 211
Query: 714 LNKVILLDPSIIEAK 728
++ DPSI +A+
Sbjct: 212 YKSILEKDPSIHQAR 226
>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
A [Homo sapiens]
Length = 608
Score = 88.6 bits (218), Expect = 2e-17
Identities = 86/344 (25%), Positives = 149/344 (43%), Gaps = 25/344 (7%)
Query: 398 RPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGGG------QGAENPAGLKSQ 451
R R RG+ +G + S R+ A+ +GHP G + K++
Sbjct: 61 RQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNK 120
Query: 452 GNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCN 511
GN+ F++G++ +A Y+ AI+L +E DLS Y NRAA + + QDC
Sbjct: 121 GNKYFKAGKYEQAIQCYTEAISLCP---TEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCT 177
Query: 512 RALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRILMEL 571
+A+EL+P +K L RRA A+E L+ + D V ++ G Q S+ ++L L
Sbjct: 178 KAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE-GFQ-NQQSMLLADKVLKLL 235
Query: 572 DGPNWREKL-SPIPAVPASVPLQAWHP-------AKEMISKQAGDSSSHRQQGITDEKTF 623
+EK + P +P+ ++++ ++ M+ + D ++ + K
Sbjct: 236 GKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKEN 295
Query: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKECA-IYTNRALCYLKLCQFEEAKQDCDQ 682
+ Q + ++NY +S+ S+ + K A RA YL + AK D D+
Sbjct: 296 SGYL-KAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDK 354
Query: 683 ALQLADGNVK----AFYRRALAHKGLKNYQKSLIDLNKVILLDP 722
+ L + NVK A +R + + S D N +DP
Sbjct: 355 VISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDP 398
Score = 80.5 bits (197), Expect = 7e-15
Identities = 48/129 (37%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 209 ATREKEKGNEAFNSGDYEEAVMYYTRSISALPTV------VAYNNRAQAEIKLQNWNSAF 262
A K KGN+ F +G YE+A+ YT +IS PT Y NRA A +LQ W
Sbjct: 114 AQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVA 173
Query: 263 QDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERD 322
QDC K +EL P VKAL RRA ++ + +E ED++ V +E + L++
Sbjct: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLK 233
Query: 323 LKNSEAASE 331
L E A E
Sbjct: 234 LLGKEKAKE 242
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 5/134 (3%)
Query: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKE-----CAIYTNRALCYLKLCQFEEAKQ 678
+A K +GN+ Y+ A+ Y+E + + E Y NRA + +L +++E Q
Sbjct: 115 QAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQ 174
Query: 679 DCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLL 738
DC +A++L VKA +RRA AH+ L N ++ L D+ V +L+ + M L + L
Sbjct: 175 DCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKL 234
Query: 739 NLKDKTAPFNKEKE 752
K+K K +E
Sbjct: 235 LGKEKAKEKYKNRE 248
Score = 48.1 bits (113), Expect = 4e-05
Identities = 48/184 (26%), Positives = 76/184 (41%), Gaps = 22/184 (11%)
Query: 171 LKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVM 230
LKI D E+ V D ++ + L + +K F R+ GN NS + A+
Sbjct: 410 LKILLDQVEEAVADFDECIRLRPE---SALAQAQKCFALYRQAYTGN---NSSQIQAAMK 463
Query: 231 YYTRSISALPTVV-AYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQ 289
+ I P Y AQA Q + A + +K ++LEP N ATTY H+
Sbjct: 464 GFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDN-------ATTYVHK 516
Query: 290 NKLR--------EATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVI 341
L+ E +SK ++++ D A +T+ +E N E A + K +
Sbjct: 517 GLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAK 576
Query: 342 QEIE 345
E+E
Sbjct: 577 SEME 580
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/164 (27%), Positives = 71/164 (43%), Gaps = 26/164 (15%)
Query: 168 KECLKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAF----NSG 223
KE K E KS+ S I + + + EK + +K+K EA NSG
Sbjct: 241 KEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEK---SDEDKDKEGEALEVKENSG 297
Query: 224 DYEEAVMY-----YTRSISALPTVVAYNNRAQAE---------IKLQNWNSAFQDCEKVL 269
Y +A Y Y + IS + + AE + + N N+A D +KV+
Sbjct: 298 -YLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVI 356
Query: 270 ELEPGNVK----ALLRRATTYKHQNKLREATEDLSKVLDVEPDN 309
L+ NVK AL++R + Y Q + +T+D + D++P N
Sbjct: 357 SLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQN 400
>gi|17149853 WAF-1/CIP1 stabilizing protein 39 [Homo sapiens]
Length = 349
Score = 80.5 bits (197), Expect = 7e-15
Identities = 51/142 (35%), Positives = 74/142 (52%), Gaps = 9/142 (6%)
Query: 196 DTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTV---------VAYN 246
D+ L EK+ LA E+ +G E F +G+ E A Y R++ L T+ V +
Sbjct: 197 DSWELETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHA 256
Query: 247 NRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVE 306
N A ++ L A Q C++VLE EPG++KAL RR L +AT DL KVL ++
Sbjct: 257 NLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAID 316
Query: 307 PDNDLAKKTLSEVERDLKNSEA 328
P N A++ L +V KN +A
Sbjct: 317 PKNRAAQEELGKVVIQGKNQDA 338
Score = 62.8 bits (151), Expect = 1e-09
Identities = 40/116 (34%), Positives = 58/116 (50%)
Query: 449 KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQ 508
+++G ELFR+G AA Y A+ LL + ++L++N AAC L G Q
Sbjct: 214 RARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQ 273
Query: 509 DCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRL 564
C+R LE P +K L RR +A L KA D K VL ID + A + + ++
Sbjct: 274 SCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKV 329
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 10/127 (7%)
Query: 618 TDEKTFKALKEE--GNQCVNDKNYKDALSKYSECLKI--------NNKECAIYTNRALCY 667
T EK A +E G + N + A Y L++ + ++ N A C
Sbjct: 203 TSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQ 262
Query: 668 LKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEA 727
L L Q + A Q CD+ L+ G++KA YRR +A L N +K+ DL KV+ +DP A
Sbjct: 263 LLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAA 322
Query: 728 KMELEEV 734
+ EL +V
Sbjct: 323 QEELGKV 329
>gi|19923193 heat shock 70kD protein binding protein [Homo sapiens]
Length = 369
Score = 75.1 bits (183), Expect = 3e-13
Identities = 79/325 (24%), Positives = 142/325 (43%), Gaps = 23/325 (7%)
Query: 98 DIKSWVSEIKKEEDKMHFHET----ETFPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKK 153
+++++V K++ +H E E +M +PP KE+ +P KK
Sbjct: 8 ELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVPPATQKAKSEENTKEE---KPDSKK 64
Query: 154 TPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREK 213
D D+ E+ L+ID++ VI+ + E + A +TE+ D A +K
Sbjct: 65 VEEDLKA-DEPSSEESDLEIDKE----GVIEPDTDAPQEMGDENAEITEEMMD-QANDKK 118
Query: 214 EKGNEAFNSGDYEEAVMYYTRSISALPTV-VAYNNRAQAEIKLQNWNSAFQDCEKVLELE 272
EA N G+ ++A+ +T +I P + + Y RA +KLQ N+A +DC++ +E+
Sbjct: 119 VAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEIN 178
Query: 273 PGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVE-RDLKNSEAASE 331
P + + R ++ EA DL+ ++ D D A L EV+ R K +E +
Sbjct: 179 PDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDED-ASAMLKEVQPRAQKIAEHRRK 237
Query: 332 TQTKGKRMVIQEIENSEDEEGKSGRKHEDGGGDKKPAEPAGAARAAQPCVMGNIQKKLTG 391
+ K + +EI+ + K+ +HE +++ +GA + P G + G
Sbjct: 238 YERKREE---REIKERIERVKKAREEHERAQREEEARRQSGAQYGSFP---GGFPGGMPG 291
Query: 392 KAEGGKRPARGAPQRGQTPEAGADK 416
GG P G G G ++
Sbjct: 292 NFPGG-MPGMGGGMPGMAGMPGLNE 315
Score = 61.6 bits (148), Expect = 3e-09
Identities = 40/173 (23%), Positives = 87/173 (50%), Gaps = 4/173 (2%)
Query: 604 KQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNR 663
++ GD ++ + + D+ K K + +ND + A+ +++ +K+N + +Y R
Sbjct: 97 QEMGDENAEITEEMMDQANDK--KVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKR 154
Query: 664 ALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPS 723
A ++KL + A +DCD+A+++ + + + R AH+ L +++++ DL LD
Sbjct: 155 ASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYD 214
Query: 724 IIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIE--IQEVNEGKEEPGRPAGE 774
+ M E R + + + +++E R+I+ I+ V + +EE R E
Sbjct: 215 EDASAMLKEVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQRE 267
Score = 47.4 bits (111), Expect = 6e-05
Identities = 33/114 (28%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 438 GGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACY 497
G + AE + Q N+ + A G+ AI L A ++ L+ILY+ RA+ +
Sbjct: 100 GDENAEITEEMMDQANDKKVAAIEALNDGELQKAIDLFTDA-IKLNPRLAILYAKRASVF 158
Query: 498 LKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID 551
+K + I+DC+RA+E++P S +P R A+ L + +A D ++D
Sbjct: 159 VKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLD 212
>gi|4503729 FK506 binding protein 52 [Homo sapiens]
Length = 459
Score = 74.7 bits (182), Expect = 4e-13
Identities = 53/194 (27%), Positives = 87/194 (44%), Gaps = 24/194 (12%)
Query: 187 HLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAYN 246
HL E ++ + +EK +T KE+G F G Y++A++ Y + +S L +++
Sbjct: 248 HLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFS 307
Query: 247 NR----------------AQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQN 290
N A +KLQ +++A + C K LEL+ N K L RR + N
Sbjct: 308 NEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVN 367
Query: 291 KLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDE 350
A D KVL + P+N AK L+ ++ ++ A + K++ E +E
Sbjct: 368 DFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLA------REKKLYANMFERLAEE 421
Query: 351 EGKSGRKHEDGGGD 364
E K+ K E GD
Sbjct: 422 ENKA--KAEASSGD 433
Score = 59.3 bits (142), Expect = 2e-08
Identities = 37/121 (30%), Positives = 60/121 (49%), Gaps = 15/121 (12%)
Query: 626 LKEEGNQCVNDKNYKDALSKYSECLK-------INNKEC--------AIYTNRALCYLKL 670
+KE G + YK AL +Y + + +N+E A + N A+C+LKL
Sbjct: 273 VKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKL 332
Query: 671 CQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKME 730
F A + C++AL+L N K +RR AH + +++ + D KV+ L P+ AK +
Sbjct: 333 QAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQ 392
Query: 731 L 731
L
Sbjct: 393 L 393
Score = 52.0 bits (123), Expect = 3e-06
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 7/110 (6%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGS---EIADDLSIL----YSNRAACYLKE 500
+K +G F+ G++ +A +Y ++ LE S E A L + N A C+LK
Sbjct: 273 VKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKL 332
Query: 501 GNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQI 550
S I+ CN+ALEL + K L RR A+ + + A D++ VLQ+
Sbjct: 333 QAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQL 382
>gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]
Length = 705
Score = 72.0 bits (175), Expect = 2e-12
Identities = 61/205 (29%), Positives = 94/205 (45%), Gaps = 29/205 (14%)
Query: 165 DVEKECLKIDEDYKE---KTVIDKSHLSKIETRIDTAG-------LTEKEKD-------- 206
+ EK L ++ED +E +T ++K+ +S +T + +A L EKD
Sbjct: 40 ETEKRLLLMEEDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEKDAKERAKRR 99
Query: 207 ----FLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTV-VAYNNRAQAEIKLQNWNSA 261
LA KEKGNEAF G+YE A++ Y+ + L + V Y NRAQA +KL+++ A
Sbjct: 100 RENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKA 159
Query: 262 FQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPD-NDLAKKTLSEVE 320
DCE L+ + KA + E K+L++ P K L++V+
Sbjct: 160 LVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLQTQVKGYLNQVD 219
Query: 321 ----RDLKNSEAASETQTKGKRMVI 341
DL+ E A E GK +
Sbjct: 220 LQEKADLQEKE-AHELLDSGKNTAV 243
Score = 72.0 bits (175), Expect = 2e-12
Identities = 43/147 (29%), Positives = 80/147 (54%), Gaps = 6/147 (4%)
Query: 602 ISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYT 661
+ K A + + R++ ++ ALKE+GN+ + NY+ A+ +YSE L+ +YT
Sbjct: 88 VEKDAKERAKRRRE---NKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYT 144
Query: 662 NRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLD 721
NRA Y+KL +E+A DC+ AL+ + KA++ A+ LKNY S K++ ++
Sbjct: 145 NRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEIN 204
Query: 722 PSI---IEAKMELEEVTRLLNLKDKTA 745
P + ++ + ++ +L++K A
Sbjct: 205 PKLQTQVKGYLNQVDLQEKADLQEKEA 231
Score = 52.0 bits (123), Expect = 3e-06
Identities = 33/108 (30%), Positives = 50/108 (46%), Gaps = 8/108 (7%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
LK +GNE F G + A +YS + L+ D+ +LY+NRA Y+K + +
Sbjct: 109 LKEKGNEAFAEGNYETAILRYSEGLEKLK--------DMKVLYTNRAQAYMKLEDYEKAL 160
Query: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQ 555
DC AL+ K A L+ Y + YK +L+I+ LQ
Sbjct: 161 VDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLQ 208
>gi|89179321 smooth muscle cell associated protein-1 isoform 3 [Homo
sapiens]
Length = 929
Score = 70.5 bits (171), Expect = 7e-12
Identities = 45/166 (27%), Positives = 85/166 (51%), Gaps = 13/166 (7%)
Query: 213 KEKGNEAFNSGDYEEAVMYYTRSISALPT----VVAYNNRAQAEIKLQNWNSAFQDCEKV 268
+++GNE F GDY A+ YT+++ T V + NRA +KL++++ A + K
Sbjct: 10 RKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKA 69
Query: 269 LELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNS-E 327
+E + G+VKAL RR+ + +L +A DL + + +EP N + ++ L + ++
Sbjct: 70 IEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVR 129
Query: 328 AASETQTKGKRM---VIQEIENSEDEEGKSGRK-----HEDGGGDK 365
S T K ++M ++ E +++ K+ + ED G +K
Sbjct: 130 YMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVVLAREDAGAEK 175
Score = 63.9 bits (154), Expect = 6e-10
Identities = 31/100 (31%), Positives = 62/100 (62%), Gaps = 3/100 (3%)
Query: 626 LKEEGNQCVNDKNYKDALSKYSECLKIN---NKECAIYTNRALCYLKLCQFEEAKQDCDQ 682
L++EGN+ +Y AL+ Y++ L ++ + ++ NRA C+LKL +++A+ + +
Sbjct: 9 LRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASK 68
Query: 683 ALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDP 722
A++ G+VKA YRR+ A + L ++++DL + + L+P
Sbjct: 69 AIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEP 108
Score = 55.5 bits (132), Expect = 2e-07
Identities = 31/104 (29%), Positives = 55/104 (52%), Gaps = 5/104 (4%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
L+ +GNELF+ G + A Y+ A+ L D ++L+ NRAAC+LK +
Sbjct: 9 LRKEGNELFKCGDYGGALAAYTQALGL-----DATPQDQAVLHRNRAACHLKLEDYDKAE 63
Query: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID 551
+ ++A+E +K L RR+ A E L + +A +D + + ++
Sbjct: 64 TEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLE 107
>gi|29725607 smooth muscle cell associated protein-1 isoform 2 [Homo
sapiens]
Length = 944
Score = 70.5 bits (171), Expect = 7e-12
Identities = 45/166 (27%), Positives = 85/166 (51%), Gaps = 13/166 (7%)
Query: 213 KEKGNEAFNSGDYEEAVMYYTRSISALPT----VVAYNNRAQAEIKLQNWNSAFQDCEKV 268
+++GNE F GDY A+ YT+++ T V + NRA +KL++++ A + K
Sbjct: 25 RKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKA 84
Query: 269 LELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNS-E 327
+E + G+VKAL RR+ + +L +A DL + + +EP N + ++ L + ++
Sbjct: 85 IEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVR 144
Query: 328 AASETQTKGKRM---VIQEIENSEDEEGKSGRK-----HEDGGGDK 365
S T K ++M ++ E +++ K+ + ED G +K
Sbjct: 145 YMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVVLAREDAGAEK 190
Score = 63.9 bits (154), Expect = 6e-10
Identities = 31/100 (31%), Positives = 62/100 (62%), Gaps = 3/100 (3%)
Query: 626 LKEEGNQCVNDKNYKDALSKYSECLKIN---NKECAIYTNRALCYLKLCQFEEAKQDCDQ 682
L++EGN+ +Y AL+ Y++ L ++ + ++ NRA C+LKL +++A+ + +
Sbjct: 24 LRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASK 83
Query: 683 ALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDP 722
A++ G+VKA YRR+ A + L ++++DL + + L+P
Sbjct: 84 AIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEP 123
Score = 57.8 bits (138), Expect = 5e-08
Identities = 33/111 (29%), Positives = 58/111 (52%), Gaps = 5/111 (4%)
Query: 441 GAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKE 500
GA + L+ +GNELF+ G + A Y+ A+ L D ++L+ NRAAC+LK
Sbjct: 17 GASSVEQLRKEGNELFKCGDYGGALAAYTQALGL-----DATPQDQAVLHRNRAACHLKL 71
Query: 501 GNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID 551
+ + ++A+E +K L RR+ A E L + +A +D + + ++
Sbjct: 72 EDYDKAETEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLE 122
>gi|24308141 small glutamine-rich tetratricopeptide repeat
(TPR)-containing, beta [Homo sapiens]
Length = 304
Score = 70.5 bits (171), Expect = 7e-12
Identities = 45/127 (35%), Positives = 64/127 (50%), Gaps = 3/127 (2%)
Query: 209 ATREKEKGNEAFNSGDYEEAVMYYTRSISALPT-VVAYNNRAQAEIKLQNWNSAFQDCEK 267
A + K++GN +Y AV YT++I P V Y NRA A+ KL ++ A +DCEK
Sbjct: 85 ADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEK 144
Query: 268 VLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSE 327
+ ++ KA R NK EA K LD++P+ND K L E+ L+ E
Sbjct: 145 AIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLR--E 202
Query: 328 AASETQT 334
+S T T
Sbjct: 203 VSSPTGT 209
Score = 61.6 bits (148), Expect = 3e-09
Identities = 31/107 (28%), Positives = 57/107 (53%)
Query: 626 LKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQ 685
LK+EGN + ++NY A+ Y++ ++++ Y NRA KL + +A +DC++A+
Sbjct: 88 LKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIA 147
Query: 686 LADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELE 732
+ KA+ R LA L +++++ K + LDP K L+
Sbjct: 148 IDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLK 194
Score = 48.1 bits (113), Expect = 4e-05
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 8/104 (7%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
LK +GN + +A A Y+ AI E+ + ++ Y NRAA K G+ + I
Sbjct: 88 LKDEGNNHMKEENYAAAVDCYTQAI--------ELDPNNAVYYCNRAAAQSKLGHYTDAI 139
Query: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID 551
+DC +A+ + K R +A L ++ +A Y+ L +D
Sbjct: 140 KDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLD 183
>gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Homo
sapiens]
Length = 420
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/128 (31%), Positives = 71/128 (55%), Gaps = 8/128 (6%)
Query: 619 DEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQ 678
+EK + LK++GN+ +NY A++ Y+ +++NNK +Y NRA C+LKL +A +
Sbjct: 286 EEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIE 345
Query: 679 DCDQALQL--------ADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKME 730
D +AL+L A+ +KA RR A L+ Y + L D + +DPS +++
Sbjct: 346 DSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSNKIVQID 405
Query: 731 LEEVTRLL 738
E++ ++
Sbjct: 406 AEKIRNVI 413
Score = 63.9 bits (154), Expect = 6e-10
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 16/134 (11%)
Query: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGN 502
+NP LK +GN+LF + + A Y+ AI L + + +LY NRAAC+LK N
Sbjct: 288 KNPEWLKDKGNKLFATENYLAAINAYNLAIRL--------NNKMPLLYLNRAACHLKLKN 339
Query: 503 CSGCIQDCNRALEL--HPFS------MKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGL 554
I+D ++ALEL P + MK +RR A+ LE Y + DY+ L+ID
Sbjct: 340 LHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSN 399
Query: 555 QLANDSVNRLSRIL 568
++ ++ ++
Sbjct: 400 KIVQIDAEKIRNVI 413
Score = 56.6 bits (135), Expect = 1e-07
Identities = 65/263 (24%), Positives = 111/263 (42%), Gaps = 32/263 (12%)
Query: 89 AEEWEKIDGDIKSWVSEIK-KEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSK 147
AEE +KI + K E + KEE K +++ T NL P ++ + K K
Sbjct: 169 AEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDS 228
Query: 148 RPTKKK--------TPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAG 199
P + TPR V L+ + +E+ + K ++ D A
Sbjct: 229 IPAPRSVGSIKINFTPR---------VFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
Query: 200 LTE-KEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSI---SALPTVVAYNNRAQAEIKL 255
L + KE++ K+KGN+ F + +Y A+ Y +I + +P + Y NRA +KL
Sbjct: 280 LCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLL--YLNRAACHLKL 337
Query: 256 QNWNSAFQDCEKVLEL--------EPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEP 307
+N + A +D K LEL +KA +RR T + E +D L ++P
Sbjct: 338 KNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDP 397
Query: 308 DNDLAKKTLSEVERDLKNSEAAS 330
N + + ++ ++ +E S
Sbjct: 398 SNKIVQIDAEKIRNVIQGTELKS 420
>gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]
Length = 313
Score = 69.7 bits (169), Expect = 1e-11
Identities = 47/125 (37%), Positives = 63/125 (50%), Gaps = 3/125 (2%)
Query: 209 ATREKEKGNEAFNSGDYEEAVMYYTRSISALPT-VVAYNNRAQAEIKLQNWNSAFQDCEK 267
A R K +GNE ++E AV +Y ++I P V + NRA A KL N+ A QDCE+
Sbjct: 91 AERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCER 150
Query: 268 VLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSE 327
+ ++P KA R NK EA K L+++PDN+ K L E LK E
Sbjct: 151 AICIDPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAE--LKLRE 208
Query: 328 AASET 332
A S T
Sbjct: 209 APSPT 213
Score = 61.2 bits (147), Expect = 4e-09
Identities = 44/141 (31%), Positives = 63/141 (44%), Gaps = 21/141 (14%)
Query: 411 EAGADKRSPRRASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSA 470
E D RSP R P + + LK++GNE + F A Y
Sbjct: 70 EMPQDLRSPART-------------PPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGK 116
Query: 471 AIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMA 530
AI L PA + + + NRAA Y K GN +G +QDC RA+ + P K R +A
Sbjct: 117 AIEL-NPANA-------VYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLA 168
Query: 531 YETLEQYGKAYVDYKTVLQID 551
+L ++ +A YK L++D
Sbjct: 169 LSSLNKHVEAVAYYKKALELD 189
Score = 60.8 bits (146), Expect = 5e-09
Identities = 46/164 (28%), Positives = 77/164 (46%), Gaps = 8/164 (4%)
Query: 585 AVPASVP--LQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDA 642
A+P ++P +A KEM Q S + D + LK EGN+ + +N++ A
Sbjct: 53 ALPQTLPEIFEAAATGKEM--PQDLRSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAA 110
Query: 643 LSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHK 702
+ Y + +++N + NRA Y KL + A QDC++A+ + KA+ R LA
Sbjct: 111 VHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLALS 170
Query: 703 GLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAP 746
L + +++ K + LDP K L ++ LK + AP
Sbjct: 171 SLNKHVEAVAYYKKALELDPDNETYKSNL----KIAELKLREAP 210
>gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens]
Length = 499
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/155 (30%), Positives = 78/155 (50%), Gaps = 8/155 (5%)
Query: 213 KEKGNEAFNSGDYEEAVMYYTRSISALPT-VVAYNNRAQAEIKLQNWNSAFQDCEKVLEL 271
K + N+ F + DYE A+ +Y+++I P+ + Y NR+ A ++ + + A D + +EL
Sbjct: 32 KTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIEL 91
Query: 272 EPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASE 331
+ +K RRA + K R A D V+ V+P + AK E + +K + A E
Sbjct: 92 DKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVK--QKAFE 149
Query: 332 TQTKG---KRMVIQ--EIENSEDEEGKSGRKHEDG 361
G KR V+ +IE+ E+ SG K EDG
Sbjct: 150 RAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDG 184
Score = 68.6 bits (166), Expect = 3e-11
Identities = 36/136 (26%), Positives = 71/136 (52%)
Query: 621 KTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDC 680
K + LK + N K+Y++A+ YS+ +++N Y NR+L YL+ + A D
Sbjct: 26 KRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDA 85
Query: 681 DQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNL 740
+A++L +K +YRRA ++ L ++ +L D V+ + P +AKM+ +E +++
Sbjct: 86 TRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQ 145
Query: 741 KDKTAPFNKEKERRKI 756
K ++ +R +
Sbjct: 146 KAFERAIAGDEHKRSV 161
Score = 48.9 bits (115), Expect = 2e-05
Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 8/103 (7%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
LK+Q N+ F++ + A YS AI E+ +I Y NR+ YL+ +
Sbjct: 31 LKTQANDYFKAKDYENAIKFYSQAI--------ELNPSNAIYYGNRSLAYLRTECYGYAL 82
Query: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQI 550
D RA+EL +K RRA + L ++ A DY+TV+++
Sbjct: 83 GDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKV 125
>gi|224809329 FK506 binding protein 5 isoform 1 [Homo sapiens]
Length = 457
Score = 67.4 bits (163), Expect = 6e-11
Identities = 51/195 (26%), Positives = 78/195 (40%), Gaps = 16/195 (8%)
Query: 188 LSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPT------ 241
L E ++ + KEK A KEKG F G Y +AV+ Y + +S L
Sbjct: 247 LKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSE 306
Query: 242 ----------VVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNK 291
+ A+ N A +KL+ + A + C+K L L+ N K L RR N+
Sbjct: 307 KESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNE 366
Query: 292 LREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEE 351
A D KVL+V P N A+ +S ++ K E + E+
Sbjct: 367 FESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEAN 426
Query: 352 GKSGRKHEDGGGDKK 366
G+K +G ++K
Sbjct: 427 KAMGKKTSEGVTNEK 441
Score = 61.6 bits (148), Expect = 3e-09
Identities = 51/198 (25%), Positives = 91/198 (45%), Gaps = 28/198 (14%)
Query: 618 TDEKTFKA--LKEEGNQCVNDKNYKDALSKYSECLK-------INNKEC--------AIY 660
T EK +A +KE+G Y A+ +Y + + ++ KE A +
Sbjct: 261 TKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAF 320
Query: 661 TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL 720
N A+CYLKL ++ +A + CD+AL L N K YRR A + ++ + D KV+ +
Sbjct: 321 LNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEV 380
Query: 721 DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERR----KIEIQEVNEGKEEPGRPAGEVS 776
+P A+++ +++ K A + E++RR + + KEE + G+ +
Sbjct: 381 NPQNKAARLQ-------ISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKT 433
Query: 777 MGCLASEKGGKSSRSPED 794
+ +EKG S E+
Sbjct: 434 SEGVTNEKGTDSQAMEEE 451
Score = 49.7 bits (117), Expect = 1e-05
Identities = 49/197 (24%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLE------PAGSEIADD-LSILYSNRAA 495
E A +K +G F+ G++ +A +Y ++ LE S+ ++ L + N A
Sbjct: 266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAM 325
Query: 496 CYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQ 555
CYLK + ++ C++AL L + K L RR A + ++ A D++ VL++
Sbjct: 326 CYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEV----- 380
Query: 556 LANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQ-AWHPAKEMISKQAGDSSSHRQ 614
+ N+ +R+ + + +E + A++ + A AKE +K G +S
Sbjct: 381 ---NPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTS--- 434
Query: 615 QGITDEK--TFKALKEE 629
+G+T+EK +A++EE
Sbjct: 435 EGVTNEKGTDSQAMEEE 451
>gi|224809327 FK506 binding protein 5 isoform 1 [Homo sapiens]
Length = 457
Score = 67.4 bits (163), Expect = 6e-11
Identities = 51/195 (26%), Positives = 78/195 (40%), Gaps = 16/195 (8%)
Query: 188 LSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPT------ 241
L E ++ + KEK A KEKG F G Y +AV+ Y + +S L
Sbjct: 247 LKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSE 306
Query: 242 ----------VVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNK 291
+ A+ N A +KL+ + A + C+K L L+ N K L RR N+
Sbjct: 307 KESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNE 366
Query: 292 LREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEE 351
A D KVL+V P N A+ +S ++ K E + E+
Sbjct: 367 FESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEAN 426
Query: 352 GKSGRKHEDGGGDKK 366
G+K +G ++K
Sbjct: 427 KAMGKKTSEGVTNEK 441
Score = 61.6 bits (148), Expect = 3e-09
Identities = 51/198 (25%), Positives = 91/198 (45%), Gaps = 28/198 (14%)
Query: 618 TDEKTFKA--LKEEGNQCVNDKNYKDALSKYSECLK-------INNKEC--------AIY 660
T EK +A +KE+G Y A+ +Y + + ++ KE A +
Sbjct: 261 TKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAF 320
Query: 661 TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL 720
N A+CYLKL ++ +A + CD+AL L N K YRR A + ++ + D KV+ +
Sbjct: 321 LNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEV 380
Query: 721 DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERR----KIEIQEVNEGKEEPGRPAGEVS 776
+P A+++ +++ K A + E++RR + + KEE + G+ +
Sbjct: 381 NPQNKAARLQ-------ISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKT 433
Query: 777 MGCLASEKGGKSSRSPED 794
+ +EKG S E+
Sbjct: 434 SEGVTNEKGTDSQAMEEE 451
Score = 49.7 bits (117), Expect = 1e-05
Identities = 49/197 (24%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLE------PAGSEIADD-LSILYSNRAA 495
E A +K +G F+ G++ +A +Y ++ LE S+ ++ L + N A
Sbjct: 266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAM 325
Query: 496 CYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQ 555
CYLK + ++ C++AL L + K L RR A + ++ A D++ VL++
Sbjct: 326 CYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEV----- 380
Query: 556 LANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQ-AWHPAKEMISKQAGDSSSHRQ 614
+ N+ +R+ + + +E + A++ + A AKE +K G +S
Sbjct: 381 ---NPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTS--- 434
Query: 615 QGITDEK--TFKALKEE 629
+G+T+EK +A++EE
Sbjct: 435 EGVTNEKGTDSQAMEEE 451
>gi|4758384 FK506 binding protein 5 isoform 1 [Homo sapiens]
Length = 457
Score = 67.4 bits (163), Expect = 6e-11
Identities = 51/195 (26%), Positives = 78/195 (40%), Gaps = 16/195 (8%)
Query: 188 LSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPT------ 241
L E ++ + KEK A KEKG F G Y +AV+ Y + +S L
Sbjct: 247 LKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSE 306
Query: 242 ----------VVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNK 291
+ A+ N A +KL+ + A + C+K L L+ N K L RR N+
Sbjct: 307 KESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNE 366
Query: 292 LREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEE 351
A D KVL+V P N A+ +S ++ K E + E+
Sbjct: 367 FESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEAN 426
Query: 352 GKSGRKHEDGGGDKK 366
G+K +G ++K
Sbjct: 427 KAMGKKTSEGVTNEK 441
Score = 61.6 bits (148), Expect = 3e-09
Identities = 51/198 (25%), Positives = 91/198 (45%), Gaps = 28/198 (14%)
Query: 618 TDEKTFKA--LKEEGNQCVNDKNYKDALSKYSECLK-------INNKEC--------AIY 660
T EK +A +KE+G Y A+ +Y + + ++ KE A +
Sbjct: 261 TKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAF 320
Query: 661 TNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL 720
N A+CYLKL ++ +A + CD+AL L N K YRR A + ++ + D KV+ +
Sbjct: 321 LNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEV 380
Query: 721 DPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERR----KIEIQEVNEGKEEPGRPAGEVS 776
+P A+++ +++ K A + E++RR + + KEE + G+ +
Sbjct: 381 NPQNKAARLQ-------ISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKT 433
Query: 777 MGCLASEKGGKSSRSPED 794
+ +EKG S E+
Sbjct: 434 SEGVTNEKGTDSQAMEEE 451
Score = 49.7 bits (117), Expect = 1e-05
Identities = 49/197 (24%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLE------PAGSEIADD-LSILYSNRAA 495
E A +K +G F+ G++ +A +Y ++ LE S+ ++ L + N A
Sbjct: 266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAM 325
Query: 496 CYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQ 555
CYLK + ++ C++AL L + K L RR A + ++ A D++ VL++
Sbjct: 326 CYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEV----- 380
Query: 556 LANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQ-AWHPAKEMISKQAGDSSSHRQ 614
+ N+ +R+ + + +E + A++ + A AKE +K G +S
Sbjct: 381 ---NPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTS--- 434
Query: 615 QGITDEK--TFKALKEE 629
+G+T+EK +A++EE
Sbjct: 435 EGVTNEKGTDSQAMEEE 451
>gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 2
[Homo sapiens]
Length = 438
Score = 67.4 bits (163), Expect = 6e-11
Identities = 47/151 (31%), Positives = 70/151 (46%), Gaps = 11/151 (7%)
Query: 212 EKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAYN-----NRAQAEIKLQNWNSAFQDCE 266
+KE GN+AF G+Y+ A YT ++ P + N NR KL+ + A +DC
Sbjct: 203 KKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCT 262
Query: 267 KVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNS 326
++L+ +KA LRRA Y + EA D KV E + K+ L + +LK S
Sbjct: 263 NAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKE-HKQLLKNAQLELKKS 321
Query: 327 EAASETQTKGKRMVIQEIENSEDEEGKSGRK 357
+ + G + SEDE K+ RK
Sbjct: 322 KRKDYYKILG-----VDKNASEDEIKKAYRK 347
Score = 65.1 bits (157), Expect = 3e-10
Identities = 54/206 (26%), Positives = 91/206 (44%), Gaps = 19/206 (9%)
Query: 621 KTFKALKEEGNQCVNDKNYKDALSKYSECLKIN----NKECAIYTNRALCYLKLCQFEEA 676
K KA KE+GN+ + NYK A Y+E L I+ +Y NR KL + ++A
Sbjct: 198 KALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDA 257
Query: 677 KQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTR 736
+DC A++L D +KA+ RRA + + Y++++ D KV + + +E +
Sbjct: 258 IEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTE--------KTKEHKQ 309
Query: 737 LLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGGKSSRSPEDPE 796
LL +K K+ KI + N ++E + + ++ G S+ ++ E
Sbjct: 310 LLKNAQLELKKSKRKDYYKILGVDKNASEDEIKKAYRKRALMHHPDRHSGASAEVQKEEE 369
Query: 797 KLPIAKPNNAYEFGQIINALSTRKDK 822
K E G+ LS K K
Sbjct: 370 K-------KFKEVGEAFTILSDPKKK 388
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 4/103 (3%)
Query: 449 KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQ 508
K GN+ F+ G + A Y+ A+ + +P + + LY NR K I+
Sbjct: 204 KEDGNKAFKEGNYKLAYELYTEALGI-DPNNIKTN---AKLYCNRGTVNSKLRKLDDAIE 259
Query: 509 DCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID 551
DC A++L +K LRRA Y EQY +A DY+ V Q +
Sbjct: 260 DCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTE 302
Score = 40.8 bits (94), Expect = 0.006
Identities = 24/102 (23%), Positives = 45/102 (44%)
Query: 655 KECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDL 714
K + Y NRA + L +F EA D Q+++L D V+ R H L N +
Sbjct: 4 KNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSF 63
Query: 715 NKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKI 756
+ + LD +A+ E + ++ + ++++ RK+
Sbjct: 64 QRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKV 105
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 66.2 bits (160), Expect = 1e-10
Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 11/151 (7%)
Query: 212 EKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAYN-----NRAQAEIKLQNWNSAFQDCE 266
+KE GN+AF G+Y+ A YT ++ P + N NR KL+ + A +DC
Sbjct: 259 KKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCT 318
Query: 267 KVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNS 326
++L+ +KA LRRA Y + EA D KV E + K+ L + +L+ S
Sbjct: 319 NAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKE-HKQLLKNAQLELRKS 377
Query: 327 EAASETQTKGKRMVIQEIENSEDEEGKSGRK 357
+ + G + SEDE K+ RK
Sbjct: 378 KRKDYYKILG-----VDKNASEDEIKKAYRK 403
Score = 64.7 bits (156), Expect = 4e-10
Identities = 54/206 (26%), Positives = 91/206 (44%), Gaps = 19/206 (9%)
Query: 621 KTFKALKEEGNQCVNDKNYKDALSKYSECLKIN----NKECAIYTNRALCYLKLCQFEEA 676
K KA KE+GN+ + NYK A Y+E L I+ +Y NR KL + ++A
Sbjct: 254 KALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDA 313
Query: 677 KQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTR 736
+DC A++L D +KA+ RRA + + Y++++ D KV + + +E +
Sbjct: 314 IEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTE--------KTKEHKQ 365
Query: 737 LLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGGKSSRSPEDPE 796
LL +K K+ KI + N ++E + + ++ G S+ ++ E
Sbjct: 366 LLKNAQLELRKSKRKDYYKILGVDKNASEDEIKKAYRKRALMHHPDRHSGASAEVQKEEE 425
Query: 797 KLPIAKPNNAYEFGQIINALSTRKDK 822
K E G+ LS K K
Sbjct: 426 K-------KFKEVGEAFTILSDPKKK 444
Score = 57.0 bits (136), Expect = 8e-08
Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 3/143 (2%)
Query: 614 QQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQF 673
Q+ + +TFK E+GN K+Y +A + Y++ + + K + Y NRA + L +F
Sbjct: 22 QEAKREAETFK---EQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRF 78
Query: 674 EEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEE 733
EA D Q+++L D V+ R H L N + + + LD +A+ E +
Sbjct: 79 REALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKN 138
Query: 734 VTRLLNLKDKTAPFNKEKERRKI 756
++ + ++++ RK+
Sbjct: 139 ANAVMEYEKIAETDFEKRDFRKV 161
Score = 50.8 bits (120), Expect = 6e-06
Identities = 34/133 (25%), Positives = 59/133 (44%), Gaps = 8/133 (6%)
Query: 200 LTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVA-YNNRAQAEIKLQNW 258
L ++E A KE+GN + DY EA YYT++I P + Y NRA + L +
Sbjct: 19 LDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRF 78
Query: 259 NSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSE 318
A D ++ + L+ V+ LR + A + L+++ N ++
Sbjct: 79 REALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKN-------AQ 131
Query: 319 VERDLKNSEAASE 331
+++ KN+ A E
Sbjct: 132 AQQEFKNANAVME 144
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 4/103 (3%)
Query: 449 KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQ 508
K GN+ F+ G + A Y+ A+ + +P + + LY NR K I+
Sbjct: 260 KEDGNKAFKEGNYKLAYELYTEALGI-DPNNIKTN---AKLYCNRGTVNSKLRKLDDAIE 315
Query: 509 DCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID 551
DC A++L +K LRRA Y EQY +A DY+ V Q +
Sbjct: 316 DCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTE 358
Score = 31.6 bits (70), Expect = 3.6
Identities = 68/297 (22%), Positives = 109/297 (36%), Gaps = 46/297 (15%)
Query: 449 KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQ 508
K QGN + + EA Y+ AI + S Y NRAA + G +
Sbjct: 32 KEQGNAYYAKKDYNEAYNYYTKAIDMCPKNAS--------YYGNRAATLMMLGRFREALG 83
Query: 509 DCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRIL 568
D +++ L ++ LR + +L A ++ L++D A + ++
Sbjct: 84 DAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVM 143
Query: 569 -MELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALK 627
E EK V + PA HR FK LK
Sbjct: 144 EYEKIAETDFEKRDFRKVVFCMDRALEFAPA------------CHR---------FKILK 182
Query: 628 EEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALC-YLKLCQFEEAKQDCDQALQL 686
E + Y +A S S+ L++++ R LC Y + C E+A Q QAL++
Sbjct: 183 AECLAMLG--RYPEAQSVASDILRMDSTNADALYVRGLCLYYEDC-IEKAVQFFVQALRM 239
Query: 687 ADGNVKAFY--RRALAHKGLK----------NYQKSLIDLNKVILLDPSIIEAKMEL 731
A + KA R A A K K NY+ + + + +DP+ I+ +L
Sbjct: 240 APDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKL 296
>gi|52630440 FK506-binding protein 8 [Homo sapiens]
Length = 413
Score = 65.9 bits (159), Expect = 2e-10
Identities = 46/157 (29%), Positives = 72/157 (45%), Gaps = 21/157 (13%)
Query: 196 DTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPT-------------- 241
D LT +E+ LA R++E GN + D+ A Y +I A+ +
Sbjct: 209 DLEMLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQL 268
Query: 242 ----VVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATE 297
V NN A +++KL ++ +A + C VLE +P N+KAL R+ Q + EA
Sbjct: 269 LQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIP 328
Query: 298 DLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQT 334
L L +EP N K +E+ + +K A T+T
Sbjct: 329 ILRAALKLEPSN---KTIHAELSKLVKKHAAQRSTET 362
Score = 32.3 bits (72), Expect = 2.1
Identities = 22/77 (28%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 662 NRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYR--RALAHKGLKNYQKSLIDLNKVIL 719
N A LKL + A + C L+ N+KA +R + LA +G Y +++ L +
Sbjct: 278 NLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQG--EYSEAIPILRAALK 335
Query: 720 LDPSIIEAKMELEEVTR 736
L+PS EL ++ +
Sbjct: 336 LEPSNKTIHAELSKLVK 352
>gi|56181387 STIP1 homology and U-box containing protein 1 [Homo
sapiens]
Length = 303
Score = 64.3 bits (155), Expect = 5e-10
Identities = 33/95 (34%), Positives = 53/95 (55%)
Query: 626 LKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQ 685
LKE+GN+ + Y +A + Y + N YTNRALCYLK+ Q E+A DC +AL+
Sbjct: 29 LKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRALE 88
Query: 686 LADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILL 720
L +VKA + +++Y +++ +L + L
Sbjct: 89 LDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSL 123
Score = 58.5 bits (140), Expect = 3e-08
Identities = 41/113 (36%), Positives = 54/113 (47%), Gaps = 10/113 (8%)
Query: 430 GGATGHPGGGQGAENPAG--LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLS 487
GGA GGG ++P+ LK QGN LF ++ EAA Y AI P ++
Sbjct: 9 GGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITR-NPL-------VA 60
Query: 488 ILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKA 540
+ Y+NRA CYLK + DC RALEL S+K +E Y +A
Sbjct: 61 VYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEA 113
Score = 57.0 bits (136), Expect = 8e-08
Identities = 60/211 (28%), Positives = 81/211 (38%), Gaps = 26/211 (12%)
Query: 198 AGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTV-VAYNNRAQAEIKLQ 256
AG EK A KE+GN F Y EA Y R+I+ P V V Y NRA +K+Q
Sbjct: 15 AGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQ 74
Query: 257 NWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDL----- 311
A DC + LEL+ +VKA EA +L + + + L
Sbjct: 75 QHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDD 134
Query: 312 --------AKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHEDGGG 363
KK + +E + E SE + R++ E E +E R HE G
Sbjct: 135 IPSALRIAKKKRWNSIEERRIHQE--SELHSYLSRLIAAERERELEE---CQRNHE---G 186
Query: 364 DKKPAEPAGAARAAQPCVMGNIQKKLTGKAE 394
D E RA Q C+ K + E
Sbjct: 187 D----EDDSHVRAQQACIEAKHDKYMADMDE 213
>gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens]
Length = 929
Score = 64.3 bits (155), Expect = 5e-10
Identities = 46/167 (27%), Positives = 81/167 (48%), Gaps = 10/167 (5%)
Query: 626 LKEEGNQCVNDKNYKDALSKYSECLKINNKEC---AIYTNRALCYLKLCQFEEAKQDCDQ 682
LKEEGN+ ++YK A + YS+ LK+ + +Y NRA C LK + +A D +
Sbjct: 9 LKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASR 68
Query: 683 ALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLN--L 740
A+ + ++KA YRR A + L ++ D+ + L+P +E+ R LN +
Sbjct: 69 AIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEP----RNQNFQEMLRRLNTSI 124
Query: 741 KDK-TAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGG 786
++K F+ + +K+ ++E E R ++ L E+ G
Sbjct: 125 QEKLRVQFSTDSRVQKMFEILLDENSEADKREKAANNLIVLGREEAG 171
Score = 60.1 bits (144), Expect = 9e-09
Identities = 43/169 (25%), Positives = 79/169 (46%), Gaps = 12/169 (7%)
Query: 209 ATREKEKGNEAFNSGDYEEAVMYYTRSISALPT----VVAYNNRAQAEIKLQNWNSAFQD 264
A + KE+GN F DY+ A Y++++ Y NRA +K +++ A D
Sbjct: 6 AVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASD 65
Query: 265 CEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLK 324
+ +++ ++KAL RR +H KL +A +D+ + +EP N ++ L + ++
Sbjct: 66 ASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQ 125
Query: 325 NS-EAASETQTKGKRMV-IQEIENSE-DEEGKSGRK-----HEDGGGDK 365
T ++ ++M I ENSE D+ K+ E+ G +K
Sbjct: 126 EKLRVQFSTDSRVQKMFEILLDENSEADKREKAANNLIVLGREEAGAEK 174
Score = 55.1 bits (131), Expect = 3e-07
Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
LK +GN F+ + A YS A+ L + L+ LY NRAAC LK +
Sbjct: 9 LKEEGNRHFQLQDYKAATNSYSQALKLTKDKAL-----LATLYRNRAACGLKTESYVQAA 63
Query: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRI 567
D +RA++++ +K L RR A E L + +A+ D + ++ Q + + RL+
Sbjct: 64 SDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTS 123
Query: 568 LME 570
+ E
Sbjct: 124 IQE 126
>gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens]
Length = 931
Score = 64.3 bits (155), Expect = 5e-10
Identities = 46/167 (27%), Positives = 81/167 (48%), Gaps = 10/167 (5%)
Query: 626 LKEEGNQCVNDKNYKDALSKYSECLKINNKEC---AIYTNRALCYLKLCQFEEAKQDCDQ 682
LKEEGN+ ++YK A + YS+ LK+ + +Y NRA C LK + +A D +
Sbjct: 9 LKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASR 68
Query: 683 ALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLN--L 740
A+ + ++KA YRR A + L ++ D+ + L+P +E+ R LN +
Sbjct: 69 AIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEP----RNQNFQEMLRRLNTSI 124
Query: 741 KDK-TAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGG 786
++K F+ + +K+ ++E E R ++ L E+ G
Sbjct: 125 QEKLRVQFSTDSRVQKMFEILLDENSEADKREKAANNLIVLGREEAG 171
Score = 60.1 bits (144), Expect = 9e-09
Identities = 43/169 (25%), Positives = 79/169 (46%), Gaps = 12/169 (7%)
Query: 209 ATREKEKGNEAFNSGDYEEAVMYYTRSISALPT----VVAYNNRAQAEIKLQNWNSAFQD 264
A + KE+GN F DY+ A Y++++ Y NRA +K +++ A D
Sbjct: 6 AVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASD 65
Query: 265 CEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLK 324
+ +++ ++KAL RR +H KL +A +D+ + +EP N ++ L + ++
Sbjct: 66 ASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQ 125
Query: 325 NS-EAASETQTKGKRMV-IQEIENSE-DEEGKSGRK-----HEDGGGDK 365
T ++ ++M I ENSE D+ K+ E+ G +K
Sbjct: 126 EKLRVQFSTDSRVQKMFEILLDENSEADKREKAANNLIVLGREEAGAEK 174
Score = 55.1 bits (131), Expect = 3e-07
Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)
Query: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
LK +GN F+ + A YS A+ L + L+ LY NRAAC LK +
Sbjct: 9 LKEEGNRHFQLQDYKAATNSYSQALKLTKDKAL-----LATLYRNRAACGLKTESYVQAA 63
Query: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRI 567
D +RA++++ +K L RR A E L + +A+ D + ++ Q + + RL+
Sbjct: 64 SDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTS 123
Query: 568 LME 570
+ E
Sbjct: 124 IQE 126
>gi|156627581 tetratricopeptide repeat domain 4 [Homo sapiens]
Length = 387
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/148 (29%), Positives = 76/148 (51%), Gaps = 13/148 (8%)
Query: 620 EKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECA-------IYTNRALCYLKLCQ 672
E+ K K+EGN +K+YK A+ Y+E LK K+CA +YTNRA L
Sbjct: 76 EEQAKTYKDEGNDYFKEKDYKKAVISYTEGLK---KKCADPDLNAVLYTNRAAAQYYLGN 132
Query: 673 FEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLD---PSIIEAKM 729
F A D A +L ++KA R AL H LK++ +++ ++ + +D ++E +
Sbjct: 133 FRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRA 192
Query: 730 ELEEVTRLLNLKDKTAPFNKEKERRKIE 757
+ +++ R+ + A ++KER + E
Sbjct: 193 KADKLKRIEQRDVRKANLKEKKERNQNE 220
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/238 (23%), Positives = 105/238 (44%), Gaps = 26/238 (10%)
Query: 143 EKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAGLTE 202
EK+ +P + D +W+K + EK L + E + L+ +++ I +
Sbjct: 19 EKFQSQPYRGGFHED--QWEK-EFEKVPLFMSRAPSEIDPRENPDLACLQSIIFDEERSP 75
Query: 203 KEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSIS---ALPTV--VAYNNRAQAEIKLQN 257
+E+ A K++GN+ F DY++AV+ YT + A P + V Y NRA A+ L N
Sbjct: 76 EEQ---AKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQYYLGN 132
Query: 258 WNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLS 317
+ SA D +L+P ++KA++R A + EA + L + D +K L
Sbjct: 133 FRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQI----DAKEKKLL 188
Query: 318 EV-----------ERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHEDGGGD 364
E+ +RD++ + + + ++Q I+ ++ + ED +
Sbjct: 189 EMRAKADKLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSEAACEDEDSASE 246
Score = 44.3 bits (103), Expect = 5e-04
Identities = 31/105 (29%), Positives = 52/105 (49%), Gaps = 8/105 (7%)
Query: 449 KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIAD-DLS-ILYSNRAACYLKEGNCSGC 506
K +GN+ F+ + +A Y+ + + AD DL+ +LY+NRAA GN
Sbjct: 83 KDEGNDYFKEKDYKKAVISYTEGLK------KKCADPDLNAVLYTNRAAAQYYLGNFRSA 136
Query: 507 IQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID 551
+ D A +L P +K ++R A+ + L+ + +A LQID
Sbjct: 137 LNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 62.0 bits (149), Expect = 2e-09
Identities = 41/181 (22%), Positives = 87/181 (48%), Gaps = 12/181 (6%)
Query: 577 REKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVND 636
RE SP PAS P+ + + I +++ D + + F + NQ +D
Sbjct: 24 REPESP----PASAPIPLF--GADTIGQRSPDGP------VLSKAEFVEKVRQSNQACHD 71
Query: 637 KNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYR 696
++ A+ Y+E L ++ + C +Y+NR+ Y+K+ Q+++A D +A L KA++R
Sbjct: 72 GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFR 131
Query: 697 RALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKI 756
+ +A + L + +L + DP ++ + + E ++D P ++ ++ K+
Sbjct: 132 QGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKL 191
Query: 757 E 757
+
Sbjct: 192 D 192
Score = 45.8 bits (107), Expect = 2e-04
Identities = 86/363 (23%), Positives = 136/363 (37%), Gaps = 29/363 (7%)
Query: 399 PARGAPQRGQTPEAGADKRSPRR--ASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELF 456
P P +G TP +R P ASA G T G + + P K++ E
Sbjct: 6 PPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTI---GQRSPDGPVLSKAEFVEKV 62
Query: 457 RSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALEL 516
R A G + AI L A + + ILYSNR+A Y+K + D +A L
Sbjct: 63 RQSNQACHDGDFHTAIVLYNEALA-VDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLL 121
Query: 517 HPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQID-CGLQLANDSVNRLSRILM-ELDGP 574
+P K R+ +A + L ++ A + + L D LQL V + M + P
Sbjct: 122 NPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEP 181
Query: 575 NWRE----KLSPIPAVPASVP----LQAWHPAKEMISKQAG---DSSSHRQQGITDEKTF 623
+++ KL P V SV L A H ++ +A + S + +G
Sbjct: 182 TYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALS 241
Query: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEA----KQD 679
A GN Y ++ L EC + N + + EA +
Sbjct: 242 SAYWSLGN-TEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQ 300
Query: 680 CDQALQLADGNVKAFYRRALAH--KGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRL 737
A++L D + +L H + +Y +L + +LL ++K EL E L
Sbjct: 301 LVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAK---QSKDELSEAREL 357
Query: 738 LNL 740
N+
Sbjct: 358 GNM 360
Score = 45.1 bits (105), Expect = 3e-04
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 5/117 (4%)
Query: 196 DTAGLTEKEKDFLATRE----KEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQ 250
DT G + L+ E + N+A + GD+ A++ Y +++ P + Y+NR+
Sbjct: 41 DTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSA 100
Query: 251 AEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEP 307
A +K+Q ++ A D K L P KA R+ ++ + +A + L +P
Sbjct: 101 AYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDP 157
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,326,082
Number of Sequences: 37866
Number of extensions: 1870113
Number of successful extensions: 10818
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 387
Number of HSP's that attempted gapping in prelim test: 9223
Number of HSP's gapped (non-prelim): 1536
length of query: 926
length of database: 18,247,518
effective HSP length: 112
effective length of query: 814
effective length of database: 14,006,526
effective search space: 11401312164
effective search space used: 11401312164
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.