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Search of human proteins with 120432044
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
(847 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 1741 0.0
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 1012 0.0
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 935 0.0
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 917 0.0
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 581 e-166
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 99 1e-20
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 99 2e-20
gi|71274148 pleckstrin homology domain containing, family G (wit... 97 5e-20
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 96 1e-19
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 96 2e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 96 2e-19
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 93 1e-18
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 93 1e-18
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 89 1e-17
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 89 1e-17
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 89 2e-17
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 87 5e-17
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 82 2e-15
gi|55749621 pleckstrin homology domain containing, family G, mem... 82 2e-15
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 80 8e-15
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 80 8e-15
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 79 1e-14
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 79 2e-14
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 79 2e-14
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 79 2e-14
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 78 3e-14
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 78 3e-14
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 75 2e-13
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 75 2e-13
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 75 3e-13
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 1741 bits (4508), Expect = 0.0
Identities = 847/847 (100%), Positives = 847/847 (100%)
Query: 1 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60
MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
Sbjct: 1 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60
Query: 61 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI 120
NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
Sbjct: 61 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI 120
Query: 121 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE 180
ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
Sbjct: 121 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE 180
Query: 181 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE 240
EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
Sbjct: 181 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE 240
Query: 241 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE 300
LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
Sbjct: 241 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE 300
Query: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA 360
DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
Sbjct: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA 360
Query: 361 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER 420
MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
Sbjct: 361 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER 420
Query: 421 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL 480
HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
Sbjct: 421 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL 480
Query: 481 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ 540
EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
Sbjct: 481 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ 540
Query: 541 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI 600
GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
Sbjct: 541 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI 600
Query: 601 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC 660
RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
Sbjct: 601 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC 660
Query: 661 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK 720
VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
Sbjct: 661 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK 720
Query: 721 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA 780
ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
Sbjct: 721 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA 780
Query: 781 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS 840
GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
Sbjct: 781 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS 840
Query: 841 TYVEEDE 847
TYVEEDE
Sbjct: 841 TYVEEDE 847
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 1012 bits (2616), Expect = 0.0
Identities = 498/849 (58%), Positives = 639/849 (75%), Gaps = 12/849 (1%)
Query: 1 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60
ME W+QC WLI C+VLP +HRVTWD AQV +LAQ LRDGVLLCQLLNNL H+INL+E+
Sbjct: 1 MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
Query: 61 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI 120
NLRPQMSQFLCLKNIRTFL+ CCE FG+++SELFEAFDLFDV+DFGKVI TLS LS TPI
Sbjct: 61 NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
Query: 121 ALATGIRPFPTEE-SINDEDIYKGLPDLIDETLVEDEEDLYDCVYGED-EGGEVYEDLMK 178
A GI PFPTEE S+ DEDIY GL D ID+T VE++EDLYDCV E+ EG E+YEDLM+
Sbjct: 121 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDT-VEEDEDLYDCVENEEAEGDEIYEDLMR 179
Query: 179 AEEAHQP-KCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFIN 237
+E P K E D R CCL EI+QTEEKYT+TL SI+++F+ PL+RFL + + +FIN
Sbjct: 180 SEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFIN 239
Query: 238 IPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISK 297
I +L+++H + ++E+ +++ NLYQVFI YKER ++YG+YCS VESA LD ++
Sbjct: 240 IEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAA 299
Query: 298 TKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLA 357
+EDV++KLEECS+RANNG+FTLRDLL+VPMQRVLKYHLLLQELVKHT + EK NL+LA
Sbjct: 300 AREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLA 359
Query: 358 LDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTK 417
LDAM+DLAQ VNEVKRDNETLR+I FQLSIENL+Q + +GRP+ DGE++IT++++ +K
Sbjct: 360 LDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSK 419
Query: 418 QERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQ 477
+R+ FL D A+++CKR+GD+Y++K+ ++L +++ ++ + D++NKKWS+ F LI QG
Sbjct: 420 MDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGA 479
Query: 478 NGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGT 537
G E + KT++LKKKW+EQFEMA+SNI P+ A +N HDF+M +F TSCK CQMLLRGT
Sbjct: 480 QGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGT 539
Query: 538 FYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKM 597
FYQGY C +C A AHKECLGRV CGR GT+K + + + + K+ + GLPKM
Sbjct: 540 FYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMK--KDKLHRRAQDKKRNELGLPKM 597
Query: 598 QVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKP 657
+V + Y G PPP GP L+L GD VEL K +A +W+GRN ++ E+G+FP + VKP
Sbjct: 598 EVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKP 657
Query: 658 CPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAK 717
P P D S WYAG MER AE+ L NR + T+LVR R K++ E+AISIKYN E K
Sbjct: 658 YVHGP-PQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVK 716
Query: 718 HIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG 777
HIKI+T +G + I E + F+ L ELVE+Y+ +SLK+ F++LDTTLQFP+KEPE R
Sbjct: 717 HIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISR- 775
Query: 778 NRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGW 837
++ S K G A ARYDFCARD ELSL +GD++KI K GWWRGE+ GRVGW
Sbjct: 776 ----PAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGW 831
Query: 838 FPSTYVEED 846
FP+ YVEED
Sbjct: 832 FPANYVEED 840
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 935 bits (2417), Expect = 0.0
Identities = 463/859 (53%), Positives = 621/859 (72%), Gaps = 36/859 (4%)
Query: 1 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60
ME W+QC +WLI CKVLP NHRV W SA VFDLAQ LRDGVLLCQLL+NL SI+LK+I
Sbjct: 1 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
Query: 61 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI 120
N RPQMSQFLCLKNIRTFL C + FG+R SELF+ FDLFDVRDFGKVI +SRLS I
Sbjct: 61 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
Query: 121 ALATGIRPFPTEESI-NDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKA 179
A GIRPFP+EE+ ND+D+Y+ L +L DE + ED+YDCV ED G ++YED++K
Sbjct: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEH--DLGEDIYDCVPCEDGGDDIYEDIIKV 178
Query: 180 EEAHQPKC--PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFIN 237
E K E+D R+CCL EI++TE KY TLE IEK +M+PL+ L+ A+ +VFIN
Sbjct: 179 EVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFIN 238
Query: 238 IPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISK 297
+ +L+K+H + ++ I S++ L +VF+++KERL+IYG+YCS +E A ++L+ +
Sbjct: 239 LEDLIKVHHSFLRAIDVSVM-VGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLA 297
Query: 298 TKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLA 357
++ED + K+EEC+ + +GKF L+DLLVVPMQRVLKYHLLL+EL+ H+ + E+ LK A
Sbjct: 298 SREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEA 357
Query: 358 LDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTK 417
L+AM+DLA Y+NEVKRD ETLR+I +FQ SIENL + FGRP+ DGE+++ ++ HTK
Sbjct: 358 LEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTK 417
Query: 418 QERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQ 477
Q+R++FLFD VIVCKRKG +YE+KEII+L +K+ ++P +K+ KKWSYGFYLIH QG+
Sbjct: 418 QDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGK 477
Query: 478 NGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGT 537
G +F+CKT+D+K+KW+EQFEMA+SNI+PD A++N H F+M+TF + T+CK C+M LRGT
Sbjct: 478 QGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGT 537
Query: 538 FYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKM 597
FYQGY+C KCG AHKECL + C K T+ PG PKM
Sbjct: 538 FYQGYMCTKCGVGAHKECLEVIPPC---------------KFTSPADLDASGAGPG-PKM 581
Query: 598 QVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKP 657
++NY G P P P L Q GD +ELL+GD S +W+GR + + + G+FPS +VKP
Sbjct: 582 VAMQNYHGNPAPP--GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKP 639
Query: 658 CPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAI 708
CP +P +DY+ PW+AG MER Q + L + + TYL+R R E+ +AI
Sbjct: 640 CPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAI 699
Query: 709 SIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKE 768
SIK+N+E KHIK++ +D + HI E +KF SL+ELVEYY+ HSLKE F+ LDTTL++PYK
Sbjct: 700 SIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKS 759
Query: 769 PEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSAN-GWW 827
E SA + +R + + +P+V+G A+ARY+F ARDMRELSL +GDVV+IY+++ + GWW
Sbjct: 760 RERSASRASSR--SPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWW 817
Query: 828 RGEVNGRVGWFPSTYVEED 846
+GE NGR+GWFPSTYVEE+
Sbjct: 818 KGETNGRIGWFPSTYVEEE 836
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 917 bits (2371), Expect = 0.0
Identities = 465/897 (51%), Positives = 623/897 (69%), Gaps = 73/897 (8%)
Query: 1 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60
ME W+QC +WLI CKVLP NHRV W SA VFDLAQ LRDGVLLCQLL+NL SI+LK+I
Sbjct: 1 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
Query: 61 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI 120
N RPQMSQFLCLKNIRTFL C + FG+R SELF+ FDLFDVRDFGKVI +SRLS I
Sbjct: 61 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
Query: 121 ALATGIRPFPTEESI-NDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKA 179
A GIRPFP+EE+ ND+D+Y+ L +L DE + ED+YDCV ED G ++YED++K
Sbjct: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEH--DLGEDIYDCVPCEDGGDDIYEDIIKV 178
Query: 180 EEAHQPKC--------PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEF 231
E QP E+D R+CCL EI++TE KY TLE IEK +M+PL+ L+ A+
Sbjct: 179 E-VQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADM 237
Query: 232 DSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISS 291
+VFIN+ +L+K+H + ++ I S++ L +VF+++KERL+IYG+YCS +E A ++
Sbjct: 238 AAVFINLEDLIKVHHSFLRAIDVSVM-VGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNT 296
Query: 292 LDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEK 351
L+ + ++ED + K+EEC+ + +GKF L+DLLVVPMQRVLKYHLLL+EL+ H+ + E+
Sbjct: 297 LNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPER 356
Query: 352 ANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITT 411
LK AL+AM+DLA Y+NEVKRD ETLR+I +FQ SIENL + FGRP+ DGE+++ +
Sbjct: 357 QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS 416
Query: 412 LDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKK-----WS 466
+ HTKQ+R++FLFD VIVCKRKG +YE+KEII+L +K+ ++P +K+ KK WS
Sbjct: 417 IVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWS 476
Query: 467 YGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTS 526
YGFYLIH QG+ G +F+CKT+D+K+KW+EQFEMA+SNI+PD A++N H F+M+TF + T+
Sbjct: 477 YGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTN 536
Query: 527 CKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRT 586
CK C+M LRGTFYQGY+C KCG AHKECL + C K T+
Sbjct: 537 CKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPC---------------KFTSPADLD 581
Query: 587 PKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGE 646
PG PKM ++NY G P P P L Q GD +ELL+GD S +W+GR + + +
Sbjct: 582 ASGAGPG-PKMVAMQNYHGNPAPP--GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRK 638
Query: 647 VGFFPSDAVKPCPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLVR 697
G+FPS +VKPCP +P +DY+ PW+AG MER Q + L + + TYL+R
Sbjct: 639 SGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIR 698
Query: 698 HRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRT 757
R E+ +AISIK+N+E KHIK++ +D + HI E +KF SL+ELVEYY+ HSLKE F+
Sbjct: 699 ERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQ 758
Query: 758 LDTTLQFPYKEPEHSAGQRGNRAGN---------------------------SLLSPKVL 790
LDTTL++PYK E SA + +R+ S+ +P+V+
Sbjct: 759 LDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVI 818
Query: 791 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSAN-GWWRGEVNGRVGWFPSTYVEED 846
G A+ARY+F ARDMRELSL +GDVV+IY+++ + GWW+GE NGR+GWFPSTYVEE+
Sbjct: 819 GTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEE 875
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 581 bits (1498), Expect = e-166
Identities = 279/279 (100%), Positives = 279/279 (100%)
Query: 569 EQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL 628
EQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL
Sbjct: 9 EQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL 68
Query: 629 KGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELIN 688
KGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELIN
Sbjct: 69 KGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELIN 128
Query: 689 RVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKH 748
RVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKH
Sbjct: 129 RVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKH 188
Query: 749 HSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELS 808
HSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELS
Sbjct: 189 HSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELS 248
Query: 809 LLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE 847
LLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
Sbjct: 249 LLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE 287
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 99.4 bits (246), Expect = 1e-20
Identities = 84/335 (25%), Positives = 160/335 (47%), Gaps = 15/335 (4%)
Query: 174 EDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR---FLTAAE 230
+D ++ H+ + +R+ + EI TE Y + L I + ++ ++ T A+
Sbjct: 222 QDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQ 281
Query: 231 FDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQV---FINYKERLVIYGQYCSGVES 287
++F NI ++ K R ++++ NK + +L ++ F+ +E IY +YC+
Sbjct: 282 LATIFGNIEDIYKFQRKFLKDLEKQY-NKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPG 340
Query: 288 AISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTT- 346
A L + K + + E C + L+ P+Q++ KY L L EL+K+TT
Sbjct: 341 ACLELANLMKQGK-YRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQ 399
Query: 347 DPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGE 406
+ + +N+K A +AMK++A +NE KR E++ +I ++Q+SI +L +
Sbjct: 400 EHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHS 459
Query: 407 IRITTLDKHTK-QERHIFLFDLAVIVCKR---KGDNYEMKEIIDLQQYKIAN-NPTTDKE 461
+T + K K Q+R FLFD ++ CK+ + D K +D+ + ++ + DK+
Sbjct: 460 GELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKD 519
Query: 462 -NKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLE 495
N F L+ F K ++ K +WL+
Sbjct: 520 CNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQ 554
Score = 39.7 bits (91), Expect = 0.012
Identities = 20/62 (32%), Positives = 32/62 (51%), Gaps = 1/62 (1%)
Query: 782 NSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPST 841
N L+S + A A +D D +EL GDV+++ + S WW G + WFP++
Sbjct: 141 NELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQV-LEASNKDWWWGRSEDKEAWFPAS 199
Query: 842 YV 843
+V
Sbjct: 200 FV 201
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 99.0 bits (245), Expect = 2e-20
Identities = 91/339 (26%), Positives = 151/339 (44%), Gaps = 37/339 (10%)
Query: 192 IRSCCLAEIKQTEEKYTETLESIEKYFMAPLK--------RFLTAAEFDSVFINIPELVK 243
+R C L EI TE Y TL ++ F+ ++ + LT +F NI ++++
Sbjct: 49 LRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILE 108
Query: 244 LHRNLMQEIHDSI--VNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKED 301
+H++ + + + ++ L VF+ +K++ +Y +YCS E A+ L ++K
Sbjct: 109 VHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKI-PT 167
Query: 302 VKLKLEECSKRA--NNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDP-TEKANLKLAL 358
V+ L C L L+ P+QR+ KY LLL+EL K T + ++ AL
Sbjct: 168 VRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSAL 227
Query: 359 DAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQ 418
AMK + +NE KR E L ++Q Q IE L Q + + + Q
Sbjct: 228 QAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQ 287
Query: 419 ERHIFLFDLAVIVCKRK-----------------GDNYEMKEIIDLQQYKIAN--NPTTD 459
ER FLFD ++ CKRK G Y + I+ + ++ N + T D
Sbjct: 288 ERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTAD 347
Query: 460 KENKKWSY-GFYLIHTQGQNGLEFYC--KTKDLKKKWLE 495
+ ++ + IH +N F C KT + K+KWL+
Sbjct: 348 YHSNGYTVTNGWKIHNTAKNKW-FVCMAKTAEEKQKWLD 385
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 97.4 bits (241), Expect = 5e-20
Identities = 72/251 (28%), Positives = 127/251 (50%), Gaps = 16/251 (6%)
Query: 199 EIKQTEEKYTETLESIEKYFMAPL----KRFLTAAEFDSVFINIPELVKLHRNLMQEIHD 254
EI +TE Y + L+SI + ++ + K L E ++F NI ++ + L+Q++ +
Sbjct: 120 EILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLEN 179
Query: 255 SIVNKNDQ-NLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRA 313
+ND + + F++ E IY QYC+ +++ L + K K E +
Sbjct: 180 C---ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRER--QET 234
Query: 314 NNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKL-ALDAMKDLAQYVNEVK 372
L L+ P+QR+LKYHLLL E+ H TE ++ L A+D M+ +A ++N++K
Sbjct: 235 LKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMK 294
Query: 373 RDNETLREIKQFQLSIENLNQPVLL-FGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIV 431
R +E +++ Q + N P L +G +G RI + K ER +FLFD +++
Sbjct: 295 RKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI----QRAKNERTLFLFDKLLLI 350
Query: 432 CKRKGDNYEMK 442
K++ D + K
Sbjct: 351 TKKRDDTFTYK 361
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 96.3 bits (238), Expect = 1e-19
Identities = 64/233 (27%), Positives = 109/233 (46%), Gaps = 33/233 (14%)
Query: 613 EGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPW 672
E L GDT+++L + +++ G GF P + ++ P PW
Sbjct: 13 ESDELAFNKGDTLKILNMEDDQNWYKAE--LRGVEGFIPKNYIRVKP----------HPW 60
Query: 673 YAGAMERLQAETELINRVN-STYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 731
Y+G + R AE L+ R + +L+R GE+++S+ Y ++ +H K+L +
Sbjct: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
Query: 732 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLG 791
KF SL ELV++Y+ T+ Q ++ E LL
Sbjct: 121 WEEKFNSLNELVDFYR-------TTTIAKKRQIFLRDEE------------PLLKSPGAC 161
Query: 792 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 844
A A++DF A+D +LS +GD++++ + + WWRG GRVG+FP +YV+
Sbjct: 162 FAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPH-WWRGRSCGRVGFFPRSYVQ 213
Score = 40.0 bits (92), Expect = 0.009
Identities = 17/51 (33%), Positives = 27/51 (52%)
Query: 793 AIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 843
++A Y F A + EL+ KGD +KI W++ E+ G G+ P Y+
Sbjct: 3 SVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
Score = 33.1 bits (74), Expect = 1.1
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 12/88 (13%)
Query: 572 TLKLPEKRTNGLR-RTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL-K 629
T + +KR LR P PG Q ++S P L + GD +E+L +
Sbjct: 137 TTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQL------SFRRGDIIEVLER 190
Query: 630 GDAHSLFWQGRNLASGEVGFFPSDAVKP 657
D H +W+GR+ G VGFFP V+P
Sbjct: 191 PDPH--WWRGRSC--GRVGFFPRSYVQP 214
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 95.5 bits (236), Expect = 2e-19
Identities = 73/265 (27%), Positives = 129/265 (48%), Gaps = 30/265 (11%)
Query: 192 IRSCCLAEIKQTEEKYTETLESIEKYFM--------APLKRFLTAAEFDSVFINIPELVK 243
+R C L+E+++TE Y TLE + F+ + + + +T +F NI +++
Sbjct: 23 LRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILA 82
Query: 244 LHRNLMQEIHDSIVNKND--QNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKED 301
+H+ ++ + + + + + Q + F+++K++ IY +YCS E A L ++K +
Sbjct: 83 VHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT- 141
Query: 302 VKLKLEECSKRAN--NGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLAL 358
++ L C N L LV P+QR+ KY L+L+EL+K T ++ A + AL
Sbjct: 142 IRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEAL 201
Query: 359 DAMKDLAQYVNEVKRDNETLREIKQFQLSIENLN--------QPVLLFGRPQGDGEIRIT 410
AMK + +NE KR E L ++++Q IE +L+ G +
Sbjct: 202 QAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCG--------VLL 253
Query: 411 TLDKHTKQERHIFLFDLAVIVCKRK 435
+ QER FLFD ++ CKRK
Sbjct: 254 KISSGNIQERVFFLFDNLLVYCKRK 278
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 95.5 bits (236), Expect = 2e-19
Identities = 73/265 (27%), Positives = 129/265 (48%), Gaps = 30/265 (11%)
Query: 192 IRSCCLAEIKQTEEKYTETLESIEKYFM--------APLKRFLTAAEFDSVFINIPELVK 243
+R C L+E+++TE Y TLE + F+ + + + +T +F NI +++
Sbjct: 23 LRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILA 82
Query: 244 LHRNLMQEIHDSIVNKND--QNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKED 301
+H+ ++ + + + + + Q + F+++K++ IY +YCS E A L ++K +
Sbjct: 83 VHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT- 141
Query: 302 VKLKLEECSKRAN--NGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLAL 358
++ L C N L LV P+QR+ KY L+L+EL+K T ++ A + AL
Sbjct: 142 IRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEAL 201
Query: 359 DAMKDLAQYVNEVKRDNETLREIKQFQLSIENLN--------QPVLLFGRPQGDGEIRIT 410
AMK + +NE KR E L ++++Q IE +L+ G +
Sbjct: 202 QAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCG--------VLL 253
Query: 411 TLDKHTKQERHIFLFDLAVIVCKRK 435
+ QER FLFD ++ CKRK
Sbjct: 254 KISSGNIQERVFFLFDNLLVYCKRK 278
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 92.8 bits (229), Expect = 1e-18
Identities = 84/333 (25%), Positives = 154/333 (46%), Gaps = 16/333 (4%)
Query: 189 ENDIRSCCLAEIKQTEEKYTETLESI-EKYFMAPLKR--FLTAAEFDSVFINIPELVKLH 245
++ +R+ + EI TE Y + L I E Y KR + + ++F NI ++ +
Sbjct: 281 KDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQ 340
Query: 246 RNLMQEIHDSIVNKNDQNLYQV---FINYKERLVIYGQYCSGVESAISSLDYISKTKEDV 302
+ ++ + N+ +L ++ F+ ++ IY +YC+ +A L ++K + V
Sbjct: 341 KAFVKALEQRF-NRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYV 399
Query: 303 KLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALDAM 361
E C +L L+ P+Q++ KY L L EL+K+T + +++ AL AM
Sbjct: 400 YF-FEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAM 458
Query: 362 KDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQ--GDGEIRITTLDKHTKQE 419
K++AQ +NE KR E + +I Q+Q SIE+ LL + GE+ T + Q+
Sbjct: 459 KNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQ 518
Query: 420 RHIFLFDLAVIVCKR---KGDNYEMKEIIDLQQYKIAN-NPTTDKENKKWSYGFYLIHTQ 475
R FLFD +I CK+ + D K +D+ ++ + D++ + +H
Sbjct: 519 RMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRG 578
Query: 476 GQNGLEFYCKTK-DLKKKWLEQFEMALSNIRPD 507
C K + K++WL+ F ++ D
Sbjct: 579 ATGDSHLLCTRKPEQKQRWLKAFAREREQVQLD 611
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
Query: 771 HSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGE 830
H G A N L+S + A A +D D +EL GDV+++ + WW G
Sbjct: 177 HPGGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWW-GR 235
Query: 831 VNGRVGWFPSTYV 843
V GWFP+++V
Sbjct: 236 VADGEGWFPASFV 248
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 92.8 bits (229), Expect = 1e-18
Identities = 84/333 (25%), Positives = 154/333 (46%), Gaps = 16/333 (4%)
Query: 189 ENDIRSCCLAEIKQTEEKYTETLESI-EKYFMAPLKR--FLTAAEFDSVFINIPELVKLH 245
++ +R+ + EI TE Y + L I E Y KR + + ++F NI ++ +
Sbjct: 281 KDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQ 340
Query: 246 RNLMQEIHDSIVNKNDQNLYQV---FINYKERLVIYGQYCSGVESAISSLDYISKTKEDV 302
+ ++ + N+ +L ++ F+ ++ IY +YC+ +A L ++K + V
Sbjct: 341 KAFVKALEQRF-NRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYV 399
Query: 303 KLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALDAM 361
E C +L L+ P+Q++ KY L L EL+K+T + +++ AL AM
Sbjct: 400 YF-FEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAM 458
Query: 362 KDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQ--GDGEIRITTLDKHTKQE 419
K++AQ +NE KR E + +I Q+Q SIE+ LL + GE+ T + Q+
Sbjct: 459 KNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQ 518
Query: 420 RHIFLFDLAVIVCKR---KGDNYEMKEIIDLQQYKIAN-NPTTDKENKKWSYGFYLIHTQ 475
R FLFD +I CK+ + D K +D+ ++ + D++ + +H
Sbjct: 519 RMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRG 578
Query: 476 GQNGLEFYCKTK-DLKKKWLEQFEMALSNIRPD 507
C K + K++WL+ F ++ D
Sbjct: 579 ATGDSHLLCTRKPEQKQRWLKAFAREREQVQLD 611
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
Query: 771 HSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGE 830
H G A N L+S + A A +D D +EL GDV+++ + WW G
Sbjct: 177 HPGGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWW-GR 235
Query: 831 VNGRVGWFPSTYV 843
V GWFP+++V
Sbjct: 236 VADGEGWFPASFV 248
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 89.4 bits (220), Expect = 1e-17
Identities = 72/282 (25%), Positives = 134/282 (47%), Gaps = 25/282 (8%)
Query: 110 ETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEG 169
ETL++LSR T + PFP + + E + L+D + + Y
Sbjct: 354 ETLAQLSRE-----TDVSPFPPRKRPSAEHSLS-IGSLLDISNTPESSINY--------- 398
Query: 170 GEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR----- 224
G+ + K+ ++ P + R E+ QTE Y L +I + F PL+
Sbjct: 399 GDTPKSCTKSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRG 458
Query: 225 --FLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKND-QNLYQVFINYKERLV-IYGQ 280
L E ++F +IP++ +H + ++ D IVN ++ +++ +F+ Y + LV Y
Sbjct: 459 GPILAPEEIKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPP 518
Query: 281 YCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQE 340
+ + E + ++ K K L+ + G+ +L +LL+ P+QR+ LLL +
Sbjct: 519 FVNFFEMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLND 578
Query: 341 LVKHTTDPT-EKANLKLALDAMKDLAQYVNEVKRDNETLREI 381
L KHT D +K+ L+ A+ ++K++ ++NE KR E ++I
Sbjct: 579 LKKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQI 620
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 89.4 bits (220), Expect = 1e-17
Identities = 74/269 (27%), Positives = 136/269 (50%), Gaps = 28/269 (10%)
Query: 188 PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR-----FLTAAEFDSVFINIPELV 242
P+ D+R + TE+ Y E+L ++ + +M PLK+ + D +F IPEL+
Sbjct: 1062 PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELL 1121
Query: 243 KLHRNLMQEIHDSIVNKN-DQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE- 300
+ H ++++ + + Q + + + + V+ Y + +++ +++ D + KE
Sbjct: 1122 EHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 1181
Query: 301 -DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALD 359
LK E S R N K L DL++ P+QR+ +Y LL+++L+KHT P + + L L+
Sbjct: 1182 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT--PEDHPDHPLLLE 1239
Query: 360 A---MKDLAQYVN-------EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRI 409
A +K +A+ +N E +R L+EI+ +E+L P+ F R + E++
Sbjct: 1240 AQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKA 1299
Query: 410 TTLDKHTKQERHIFLFDLAVIVC---KRK 435
K++R +FLF +IVC KRK
Sbjct: 1300 I----GGKKDRSLFLF-TDLIVCTTLKRK 1323
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 89.0 bits (219), Expect = 2e-17
Identities = 83/340 (24%), Positives = 155/340 (45%), Gaps = 20/340 (5%)
Query: 184 QPKCPENDIRSCCLAEIKQTEEKYTETLESI-EKYFMAPLKR--FLTAAEFDSVFINIPE 240
+P + +R+ + EI TE Y + L+ I E Y KR + + +F NI +
Sbjct: 95 RPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIED 154
Query: 241 LVKLHRNLMQEIHDSIVNKNDQNLYQV---FINYKERLVIYGQYCSGVESAISSLDYISK 297
+ + ++++ N +D +L ++ F+ +++ IY +YC+ A L SK
Sbjct: 155 IYRFQMGFVRDLEKQY-NNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMEL---SK 210
Query: 298 TKEDVKLK--LEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTT-DPTEKANL 354
+D + + E C + L+ P+Q++ KY L L EL+K+T D ++ +
Sbjct: 211 LMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYV 270
Query: 355 KLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQ--GDGEIRITTL 412
AL M+++ Q +NE KR E + +I Q+Q S+ + +L + GE+
Sbjct: 271 AAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQ 330
Query: 413 DKHTKQERHIFLFDLAVIVCKR---KGDNYEMKEIIDLQQYKIAN--NPTTDKENKKWSY 467
Q+R FLFD +++CK+ + D K ID+ +Y++ + + D N
Sbjct: 331 PYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKN 390
Query: 468 GFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPD 507
F L + + + F+ K + K +WL F ++ D
Sbjct: 391 AFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQED 430
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/72 (33%), Positives = 40/72 (55%), Gaps = 12/72 (16%)
Query: 781 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS 840
G+S++S A A +D REL+ GDV+K+ + + WW G+++ GWFP+
Sbjct: 7 GDSIVS------AEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWW-GQIDDEEGWFPA 59
Query: 841 TYV-----EEDE 847
++V +EDE
Sbjct: 60 SFVRLWVNQEDE 71
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 87.4 bits (215), Expect = 5e-17
Identities = 75/274 (27%), Positives = 128/274 (46%), Gaps = 27/274 (9%)
Query: 199 EIKQTEEKYTETLESIEKYFMAPLKRF----LTAAEFDSVFINIPELVKLHRNLMQEIHD 254
EI +TE Y L SI + ++ PL L+ + ++F NI ++ + L++++ +
Sbjct: 109 EIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLEN 168
Query: 255 SIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRAN 314
S + + + F+ E IY YC S+++ L +S + L L+E +
Sbjct: 169 S---SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPP-AALWLQERQAQLR 224
Query: 315 NGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKL---ALDAMKDLAQYVNEV 371
+ L+ L+ P+QR+LKYHLLLQEL KH + ++ A+ +M +A Y+N++
Sbjct: 225 HS-LPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDM 283
Query: 372 KRDNETLREIKQFQLSIENLNQPVL-LFG--------RPQGDGEIRITTLDKHTKQERHI 422
KR E +++ Q + P L FG R G G R+ ER +
Sbjct: 284 KRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRL------RGGERLL 337
Query: 423 FLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNP 456
FLF ++V KR+G Y K I ++ +P
Sbjct: 338 FLFSRMLLVAKRRGLEYTYKGHIFCCNLSVSESP 371
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 82.0 bits (201), Expect = 2e-15
Identities = 65/202 (32%), Positives = 104/202 (51%), Gaps = 27/202 (13%)
Query: 661 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 718
VP P + +PWY ++ R +AE +++ R+ + +L+R R + S YAI+ + + KH
Sbjct: 635 VPNPNPHESKPWYYDSLSRGEAE-DMLMRIPRDGAFLIRKR-EGSDSYAITFRARGKVKH 692
Query: 719 IKILTRDG-FFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG 777
+I RDG F + + F+SL+ELV YY+ HSL R L++P PE
Sbjct: 693 CRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPVT-PELLERYNM 745
Query: 778 NRAGNSL-------LSPKVLGIAI------ARYDFCARDMRELSLLKGDVVKIYTKMSAN 824
R NSL + P + ++ A YD+ A+ ELS +G ++ +K
Sbjct: 746 ERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSK-EPG 804
Query: 825 GWWRGEVNGRV-GWFPSTYVEE 845
GWW+G+ R+ +FPS YVE+
Sbjct: 805 GWWKGDYGTRIQQYFPSNYVED 826
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 82.0 bits (201), Expect = 2e-15
Identities = 59/220 (26%), Positives = 105/220 (47%), Gaps = 16/220 (7%)
Query: 277 IYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHL 336
IY QYC+ +++++L + K+ K + + L L+ P+QR+LKYHL
Sbjct: 123 IYTQYCNNYPNSVAALTECMRDKQQAKFFRDR--QELLQHSLPLGSYLLKPVQRILKYHL 180
Query: 337 LLQELVKHTTDPTEKAN-LKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPV 395
LLQE+ KH + + ++ A+D M +A Y+N++KR +E +++ Q + N P
Sbjct: 181 LLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPD 240
Query: 396 L-LFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIAN 454
L +G +G R+ + ER FLFD +++ K++GD++ K I +
Sbjct: 241 LTTYGELVLEGTFRV----HRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLI- 295
Query: 455 NPTTDKENKKWSYGFYLIH-TQGQNGLEFYCKTKDLKKKW 493
E+ + S F + H + KT + K+ W
Sbjct: 296 ------ESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNW 329
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 80.1 bits (196), Expect = 8e-15
Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 25/201 (12%)
Query: 661 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 718
VP+ + + WY ++ R QAE ++ RV + +LVR R E YAIS + + KH
Sbjct: 657 VPQTNAHESKEWYHASLTRAQAE-HMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKH 714
Query: 719 IKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYK----------E 768
++ ++G + N +F SL++L+ YY+ H L + L++P E
Sbjct: 715 CRV-QQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMK-----LRYPINEEALEKIGTAE 768
Query: 769 PEHSAGQRGNRAG---NSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANG 825
P++ A G G + P A +D+ A+ EL+ +K +++ K G
Sbjct: 769 PDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQE-GG 827
Query: 826 WWRGEVNGRVG-WFPSTYVEE 845
WWRG+ G+ WFPS YVEE
Sbjct: 828 WWRGDYGGKKQLWFPSNYVEE 848
Score = 33.5 bits (75), Expect = 0.85
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 4/66 (6%)
Query: 691 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGF----FHIAENRKFKSLMELVEYY 746
+ ++LVR G+Y +S N + +H +I +R F + +N F SL +L+ +Y
Sbjct: 580 DGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHY 639
Query: 747 KHHSLK 752
+ L+
Sbjct: 640 QQVPLR 645
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 80.1 bits (196), Expect = 8e-15
Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 25/201 (12%)
Query: 661 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 718
VP+ + + WY ++ R QAE ++ RV + +LVR R E YAIS + + KH
Sbjct: 657 VPQTNAHESKEWYHASLTRAQAE-HMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKH 714
Query: 719 IKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYK----------E 768
++ ++G + N +F SL++L+ YY+ H L + L++P E
Sbjct: 715 CRV-QQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMK-----LRYPINEEALEKIGTAE 768
Query: 769 PEHSAGQRGNRAG---NSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANG 825
P++ A G G + P A +D+ A+ EL+ +K +++ K G
Sbjct: 769 PDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQE-GG 827
Query: 826 WWRGEVNGRVG-WFPSTYVEE 845
WWRG+ G+ WFPS YVEE
Sbjct: 828 WWRGDYGGKKQLWFPSNYVEE 848
Score = 33.5 bits (75), Expect = 0.85
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 4/66 (6%)
Query: 691 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGF----FHIAENRKFKSLMELVEYY 746
+ ++LVR G+Y +S N + +H +I +R F + +N F SL +L+ +Y
Sbjct: 580 DGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHY 639
Query: 747 KHHSLK 752
+ L+
Sbjct: 640 QQVPLR 645
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 79.3 bits (194), Expect = 1e-14
Identities = 57/232 (24%), Positives = 105/232 (45%), Gaps = 43/232 (18%)
Query: 617 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA 676
L + GD +++L + +++ +G+ GF P + ++ P PW+ G
Sbjct: 17 LSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYIEMKP----------HPWFFGK 64
Query: 677 MERLQAETELIN-RVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDG----FFHIA 731
+ R +AE L R + +L+R G++++S+K+ N+ +H K+L RDG F +
Sbjct: 65 IPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVL-RDGAGKYFLWVV 123
Query: 732 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLG 791
KF SL ELV+Y++ S+ + ++ ++P +
Sbjct: 124 ---KFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTY-------------------- 160
Query: 792 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 843
A +DF ++ EL +GD + + N WW+G +G+ G FP YV
Sbjct: 161 -VQALFDFDPQEDGELGFRRGDFIHVMDNSDPN-WWKGACHGQTGMFPRNYV 210
Score = 50.4 bits (119), Expect = 7e-06
Identities = 21/52 (40%), Positives = 33/52 (63%)
Query: 793 AIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 844
AIA+YDF A ELS +GD++K+ + W++ E+NG+ G+ P Y+E
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 79.0 bits (193), Expect = 2e-14
Identities = 81/340 (23%), Positives = 148/340 (43%), Gaps = 78/340 (22%)
Query: 197 LAEIKQTEEKYTETLESIEKYFMAPLKR--FLTAAEFDSVFINIPELVKLHRNLMQEIHD 254
+ E+ TE+ Y + L + + ++ PL+ FLT E +S+F ++PE+++ + ++ + D
Sbjct: 29 IQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLED 88
Query: 255 SIVNKNDQNLYQV--------------FINYKERLVIYGQYCSGVESAISSLDYISKTKE 300
I +D N + F+ Y + +Y +C+ L+ +KT +
Sbjct: 89 GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLER-AKTDK 147
Query: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEK-ANLKLALD 359
K L+ + + TL L+ P+QRVLKY LLL+ELV T +E+ +L AL
Sbjct: 148 AFKAFLDARNPTKQHSS-TLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALK 206
Query: 360 AMKDLAQYVNEVKRDNE---------------TLREIKQFQL------SIENLNQPVLLF 398
AM+ +A ++NE+++ E T +E+ + + S + P L
Sbjct: 207 AMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSL 266
Query: 399 GRPQGDGEIRITTLDKHTKQERHIFLFDLAVIV-----CKRKG---------------DN 438
G+ + D E+ +F+F AVI+ CK K D
Sbjct: 267 GKARKDLELT-------------VFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDP 313
Query: 439 YEMKEIIDLQQYKI-ANNPTTDKENKKWSYGFYLIHTQGQ 477
++ + +I + ++ NP + N W LIHT+ +
Sbjct: 314 FKFRWLIPISALQVRLGNPAGTENNSIWE----LIHTKSE 349
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 79.0 bits (193), Expect = 2e-14
Identities = 81/340 (23%), Positives = 148/340 (43%), Gaps = 78/340 (22%)
Query: 197 LAEIKQTEEKYTETLESIEKYFMAPLKR--FLTAAEFDSVFINIPELVKLHRNLMQEIHD 254
+ E+ TE+ Y + L + + ++ PL+ FLT E +S+F ++PE+++ + ++ + D
Sbjct: 1104 IQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLED 1163
Query: 255 SIVNKNDQNLYQV--------------FINYKERLVIYGQYCSGVESAISSLDYISKTKE 300
I +D N + F+ Y + +Y +C+ L+ +KT +
Sbjct: 1164 GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLER-AKTDK 1222
Query: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEK-ANLKLALD 359
K L+ + + TL L+ P+QRVLKY LLL+ELV T +E+ +L AL
Sbjct: 1223 AFKAFLDARNPTKQHSS-TLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALK 1281
Query: 360 AMKDLAQYVNEVKRDNE---------------TLREIKQFQL------SIENLNQPVLLF 398
AM+ +A ++NE+++ E T +E+ + + S + P L
Sbjct: 1282 AMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSL 1341
Query: 399 GRPQGDGEIRITTLDKHTKQERHIFLFDLAVIV-----CKRKG---------------DN 438
G+ + D E+ +F+F AVI+ CK K D
Sbjct: 1342 GKARKDLELT-------------VFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDP 1388
Query: 439 YEMKEIIDLQQYKI-ANNPTTDKENKKWSYGFYLIHTQGQ 477
++ + +I + ++ NP + N W LIHT+ +
Sbjct: 1389 FKFRWLIPISALQVRLGNPAGTENNSIWE----LIHTKSE 1424
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 78.6 bits (192), Expect = 2e-14
Identities = 69/272 (25%), Positives = 128/272 (47%), Gaps = 29/272 (10%)
Query: 197 LAEIKQTEEKYTETLESIEKYFMAPLKR--FLTAAEFDSVFINIPELVKLHRNLMQEIHD 254
+ E+ +TE Y + L + + ++ PL++ FLT E D +F N+ E+V+ ++ + D
Sbjct: 1045 ICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLED 1104
Query: 255 SI--------VNKNDQ------NLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE 300
+ + K DQ +L F+ Y +R +Y +C+ + + + +KT
Sbjct: 1105 GVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCAS-HTKVPKVLVKAKTDT 1163
Query: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALD 359
K L+ + + + TL L+ P+QR+LKY LLL+EL T + E +L +A+
Sbjct: 1164 AFKAFLDAQNPKQQHSS-TLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIK 1222
Query: 360 AMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRIT--------T 411
M +A ++NE+++ +E + QL E + + GD + T +
Sbjct: 1223 TMNKVASHINEMQKIHEEFGAVFD-QLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPAS 1281
Query: 412 LDKHTKQ-ERHIFLFDLAVIVCKRKGDNYEMK 442
L K K+ E F+F AV++ + G + K
Sbjct: 1282 LGKWKKEPELAAFVFKTAVVLVYKDGSKQKKK 1313
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 78.2 bits (191), Expect = 3e-14
Identities = 68/306 (22%), Positives = 136/306 (44%), Gaps = 16/306 (5%)
Query: 199 EIKQTEEKYTETLESIEKYFMAPLKRFLTAAE-FDSVFINIPELVKLHRN-LMQEIHDSI 256
E+ TEE Y + L +++ F L E +F NI + + H L+ E+ I
Sbjct: 164 ELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223
Query: 257 VNKNDQN--LYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRAN 314
+ D N L + L +YG+Y + A+ + ++ K + K+
Sbjct: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283
Query: 315 NGKFTLRDLLVVPMQRVLKYHLLLQELVKH-TTDPTEKANLKLALDAMKDLAQYVNEVKR 373
G TL+ ++ P+QRV +Y LLL++ +K D ++ + + +L+ + A + N R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343
Query: 374 DNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCK 433
E + ++ + + V +G+I+ + T Q+RH+FLF+ ++ C
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403
Query: 434 RK----GDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDL 489
K G + ++E +D+ ++ ++ K + I T + LE +T++
Sbjct: 404 PKLRLMGQKFSVREKMDISGLQV-------QDIVKPNTAHTFIITGRKRSLELQTRTEEE 456
Query: 490 KKKWLE 495
KK+W++
Sbjct: 457 KKEWIQ 462
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 78.2 bits (191), Expect = 3e-14
Identities = 68/306 (22%), Positives = 136/306 (44%), Gaps = 16/306 (5%)
Query: 199 EIKQTEEKYTETLESIEKYFMAPLKRFLTAAE-FDSVFINIPELVKLHRN-LMQEIHDSI 256
E+ TEE Y + L +++ F L E +F NI + + H L+ E+ I
Sbjct: 164 ELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223
Query: 257 VNKNDQN--LYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRAN 314
+ D N L + L +YG+Y + A+ + ++ K + K+
Sbjct: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283
Query: 315 NGKFTLRDLLVVPMQRVLKYHLLLQELVKH-TTDPTEKANLKLALDAMKDLAQYVNEVKR 373
G TL+ ++ P+QRV +Y LLL++ +K D ++ + + +L+ + A + N R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343
Query: 374 DNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCK 433
E + ++ + + V +G+I+ + T Q+RH+FLF+ ++ C
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403
Query: 434 RK----GDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDL 489
K G + ++E +D+ ++ ++ K + I T + LE +T++
Sbjct: 404 PKLRLMGQKFSVREKMDISGLQV-------QDIVKPNTAHTFIITGRKRSLELQTRTEEE 456
Query: 490 KKKWLE 495
KK+W++
Sbjct: 457 KKEWIQ 462
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 75.5 bits (184), Expect = 2e-13
Identities = 66/266 (24%), Positives = 121/266 (45%), Gaps = 33/266 (12%)
Query: 192 IRSCCLAEIKQTEEKYTETLESI--------EKYFMAPLKRFLTAAEFDSVFINIPELVK 243
+++ L E+ QTE Y L ++ + M L L + D +F N+ E+ +
Sbjct: 555 LKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYE 614
Query: 244 LHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVK 303
H ++ ++ + ++ + F+ K+ +Y +YC E +
Sbjct: 615 FHNDIFLSSLENCAHAPER-VGPCFLERKDDFQMYAKYCQN-----------KPRSETIW 662
Query: 304 LKLEECS-----KRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLAL 358
K EC+ +R + L L+ P+QR+ KY LLL+EL+K++ D A LK AL
Sbjct: 663 RKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKAL 722
Query: 359 DAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRP----QGDGEIRITTLDK 414
DAM DL + VN D+ I + ++ L + ++ G G ++ L +
Sbjct: 723 DAMLDLLKSVN----DSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLAR 778
Query: 415 HTKQERHIFLFDLAVIVCKRKGDNYE 440
+RH+FL++ A++ CKR+ ++ E
Sbjct: 779 FKPMQRHLFLYEKAIVFCKRRVESGE 804
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 75.5 bits (184), Expect = 2e-13
Identities = 66/266 (24%), Positives = 121/266 (45%), Gaps = 33/266 (12%)
Query: 192 IRSCCLAEIKQTEEKYTETLESI--------EKYFMAPLKRFLTAAEFDSVFINIPELVK 243
+++ L E+ QTE Y L ++ + M L L + D +F N+ E+ +
Sbjct: 495 LKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYE 554
Query: 244 LHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVK 303
H ++ ++ + ++ + F+ K+ +Y +YC E +
Sbjct: 555 FHNDIFLSSLENCAHAPER-VGPCFLERKDDFQMYAKYCQN-----------KPRSETIW 602
Query: 304 LKLEECS-----KRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLAL 358
K EC+ +R + L L+ P+QR+ KY LLL+EL+K++ D A LK AL
Sbjct: 603 RKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKAL 662
Query: 359 DAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRP----QGDGEIRITTLDK 414
DAM DL + VN D+ I + ++ L + ++ G G ++ L +
Sbjct: 663 DAMLDLLKSVN----DSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLAR 718
Query: 415 HTKQERHIFLFDLAVIVCKRKGDNYE 440
+RH+FL++ A++ CKR+ ++ E
Sbjct: 719 FKPMQRHLFLYEKAIVFCKRRVESGE 744
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 75.1 bits (183), Expect = 3e-13
Identities = 63/259 (24%), Positives = 121/259 (46%), Gaps = 21/259 (8%)
Query: 193 RSCCLAEIKQTEEKYTETLESIEKYFMAPLKRF--LTAAEFDSVFINIPELVKLHRNLMQ 250
R + E+ Q EE E L+ +K + P+ + +T E + +F + L+ LH L+
Sbjct: 129 RQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLS 188
Query: 251 EIHDSIVNKND---QNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLE 307
++ D V K D +++ + + + L Y YCS +A + LD+ K V+ L+
Sbjct: 189 QLRD--VRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDH-KKQDHRVQDFLQ 245
Query: 308 ECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALDAMKDLAQ 366
C + + K L + L +P R++KY LLL+E+++HT D ++ +L+ A++ ++ +
Sbjct: 246 RCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVA 305
Query: 367 YVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER----HI 422
+N K R K+ L +E + L+ R+ K R H+
Sbjct: 306 EIN-TKTGESECRYYKERLLYLEEGQKDSLI-------DSSRVLCCHGELKNNRGVKLHV 357
Query: 423 FLFDLAVIVCKRKGDNYEM 441
FLF +++ + N ++
Sbjct: 358 FLFQEVLVITRAVTHNEQL 376
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,057,899
Number of Sequences: 37866
Number of extensions: 1565904
Number of successful extensions: 5454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 265
Number of HSP's successfully gapped in prelim test: 217
Number of HSP's that attempted gapping in prelim test: 4527
Number of HSP's gapped (non-prelim): 842
length of query: 847
length of database: 18,247,518
effective HSP length: 111
effective length of query: 736
effective length of database: 14,044,392
effective search space: 10336672512
effective search space used: 10336672512
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.