Search of human proteins with 24497531

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24497531 Ellis van Creveld syndrome protein [Homo sapiens]
         (992 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24497531 Ellis van Creveld syndrome protein [Homo sapiens]        1931   0.0  
gi|21735548 centrosomal protein 2 [Homo sapiens]                       74   7e-13
gi|16262452 cingulin [Homo sapiens]                                    60   8e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        60   1e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        60   1e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         60   1e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         60   1e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         60   1e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         60   1e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         60   1e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         60   1e-08
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    59   2e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    55   2e-07
gi|81295809 pericentrin [Homo sapiens]                                 55   4e-07
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    53   2e-06
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           52   3e-06
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           52   3e-06
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           52   3e-06
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         50   1e-05
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]             50   1e-05
gi|115511012 coiled-coil domain containing 136 [Homo sapiens]          49   2e-05
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    49   2e-05
gi|42794779 myosin 18A isoform b [Homo sapiens]                        49   2e-05
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             48   4e-05
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    48   4e-05
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    48   5e-05
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    48   5e-05
gi|148746195 trichohyalin [Homo sapiens]                               47   7e-05
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                47   7e-05
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]    47   9e-05

>gi|24497531 Ellis van Creveld syndrome protein [Homo sapiens]
          Length = 992

 Score = 1931 bits (5002), Expect = 0.0
 Identities = 992/992 (100%), Positives = 992/992 (100%)

Query: 1   MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGLWLGCRAGRQRTRHQKD 60
           MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGLWLGCRAGRQRTRHQKD
Sbjct: 1   MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGLWLGCRAGRQRTRHQKD 60

Query: 61  DTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNITAFALKAKVI 120
           DTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNITAFALKAKVI
Sbjct: 61  DTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNITAFALKAKVI 120

Query: 121 YPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHS 180
           YPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHS
Sbjct: 121 YPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHS 180

Query: 181 ATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIF 240
           ATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIF
Sbjct: 181 ATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIF 240

Query: 241 KMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVE 300
           KMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVE
Sbjct: 241 KMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVE 300

Query: 301 KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDS 360
           KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDS
Sbjct: 301 KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDS 360

Query: 361 QELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEE 420
           QELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEE
Sbjct: 361 QELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEE 420

Query: 421 LLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPT 480
           LLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPT
Sbjct: 421 LLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPT 480

Query: 481 ADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFL 540
           ADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFL
Sbjct: 481 ADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFL 540

Query: 541 QTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECAL 600
           QTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECAL
Sbjct: 541 QTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECAL 600

Query: 601 SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLT 660
           SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLT
Sbjct: 601 SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLT 660

Query: 661 QMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ 720
           QMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ
Sbjct: 661 QMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ 720

Query: 721 LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVY 780
           LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVY
Sbjct: 721 LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVY 780

Query: 781 VTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRT 840
           VTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRT
Sbjct: 781 VTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRT 840

Query: 841 AGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
           AGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ
Sbjct: 841 AGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900

Query: 901 NFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQT 960
           NFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQT
Sbjct: 901 NFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQT 960

Query: 961 SGSLSSKRLSQQESEAGDSGNSKKMLKRRSNL 992
           SGSLSSKRLSQQESEAGDSGNSKKMLKRRSNL
Sbjct: 961 SGSLSSKRLSQQESEAGDSGNSKKMLKRRSNL 992


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 213/950 (22%), Positives = 398/950 (41%), Gaps = 169/950 (17%)

Query: 138  SLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHSATSDDRFLSRTFLRVNA 197
            +L E L+ + L  + +    +    +L++ E+     SSS ++  ++   L    ++++A
Sbjct: 544  TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603

Query: 198  FPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDEL 257
              E LA + V ++  +  L  ++          E+    +Q+      DL   +K  + L
Sbjct: 604  LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV------DLAEAEKRREAL 657

Query: 258  YQKI------LSKQE----------KDLEELEKGLQVKLSNTE-MSGAGDSEYITLADVE 300
            ++K       L K E          +D++E ++ +Q KLS +     A  ++   L    
Sbjct: 658  WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA 717

Query: 301  KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDS 360
            K++ E   + +   EA  ++ A ++  L    +     A QL   L+      E  L ++
Sbjct: 718  KRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ-GLSSAKELLESSLFEA 776

Query: 361  QELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEE 420
            Q+  ++  +E T G+         L++Q+Q  T+ +        E++ GE +     K E
Sbjct: 777  QQQNSV--IEVTKGQ---------LEVQIQTVTQAK--------EVIQGEVRCL---KLE 814

Query: 421  LLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQE--EEQRSF----L 474
            L T++ +A  QE +  +R+  Q  ++  TA    +     ++   +E  E++RS+    L
Sbjct: 815  LDTERSQAE-QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873

Query: 475  AEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKF 534
            A+A  + + EK +E    + E+Q  M+    + E  R T+A  ALCQ      ++T ++ 
Sbjct: 874  AKALESLEREK-MELEMRLKEQQTEMEAIQAQREEER-TQAESALCQ----MQLETEKER 927

Query: 535  VDAL--FLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQ 592
            V  L   LQT   +     ++ + LRQ+++     +   +   + Q  +  +EL E  +Q
Sbjct: 928  VSLLETLLQTQKELADAS-QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986

Query: 593  VWMEECAL----SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSA--- 645
               +  AL    SS+LQ  +  D +  +  +  +L    ++S R V Q     LR     
Sbjct: 987  HRDDLAALQEESSSLLQDKM--DLQKQVEDLKSQLVA-QDDSQRLVEQEVQEKLRETQEY 1043

Query: 646  --LRRLALRGNALATLTQMRLSGKKHLLQE---LREQR--ALEQGSSQCLDEH-----QW 693
              +++   R  A  TL+ M    +  +LQE   +R+Q   AL Q   +   E      Q 
Sbjct: 1044 NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103

Query: 694  QLLR-----------ALEARVLEE------------ASRLEEEAQQTRLQLQQR------ 724
            +LLR           A EA++LEE            AS   +EA+  +LQL+ R      
Sbjct: 1104 ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL 1163

Query: 725  -LLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAK--------------------D 763
              LA  Q+ G   Q   + A   + L  A  +  +SR +                     
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223

Query: 764  RDDFKRTLMEAAVESVYVTSAGVSRLVQAYY--QQIGRIMEDHEERKLQHLKTLQGERME 821
            R  FKR  +  A+ +  V SA + +L Q  +  QQ   ++ D  ++  + L   + E+ +
Sbjct: 1224 RSLFKRGPLLTALSAEAVASA-LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282

Query: 822  NYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQA 881
             +   + Q+L    S ++      E  Q   +  L +    +A      Q RL   + Q 
Sbjct: 1283 VHT--ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASL----QSRLRRAELQR 1336

Query: 882  GVMDLLEAQLETQL-QEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKR----- 935
                 +EAQ E +L Q A++N  +++  L +  + E++   +  G+LE+ LRT R     
Sbjct: 1337 -----MEAQGERELLQAAKENLTAQVEHL-QAAVVEARAQASAAGILEEDLRTARSALKL 1390

Query: 936  ----------KKPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQESE 975
                      +    QE+G+L V   + L    Q + +L ++ L+++E E
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKAL----QENLALLTQTLAEREEE 1436



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 192/918 (20%), Positives = 368/918 (40%), Gaps = 129/918 (14%)

Query: 54   RTRHQKDDTQNLLKNLESNAQTPSETGSPSRRRKREVQMSK-DKEAVDECEPPSNSNITA 112
            + + +K   +    +LES      ET +  + R R  ++ + + +   E    +  N+TA
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355

Query: 113  FA--LKAKVIYPINQKFRPLADGSSNPSLHENLKQA----VLPHQPVEASPSSSLGSLSQ 166
                L+A V+          A  S+   L E+L+ A     L ++ VE+    +     Q
Sbjct: 1356 QVEHLQAAVV-------EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQ 1408

Query: 167  GEKDDCSSSSSVHSATSDDRFLSRTFLRVNAFPEVLACESVDVD---------LCIYSLH 217
            GE       +   +       L++T        E L  +  +++         L + SL 
Sbjct: 1409 GELKVAQGKALQENLA----LLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464

Query: 218  LKDLLHLDTALRQEKHMMFIQIFKMC--LLDLLPKKKSDDELYQKILSKQEKDLEELEKG 275
            LK   + +  L+QE+    IQ  + C  +L+ LP    + E  QK L+ Q + + ELEK 
Sbjct: 1465 LKKR-NQEVDLQQEQ----IQELEKCRSVLEHLPMAVQERE--QK-LTVQREQIRELEKD 1516

Query: 276  LQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVD----- 330
             + + +  E           L ++EKK++    Q    ++   KQ+  ++   ++     
Sbjct: 1517 RETQRNVLEHQ---------LLELEKKDQMIESQR-GQVQDLKKQLVTLECLALELEENH 1566

Query: 331  -QFKCSSSKARQLMMTLTERMIAAEGLLCD----SQELQALDALERTMGRAHMAKVIEFL 385
             + +C     ++L      + +A   L  D    SQELQA  +    +  +H   +   L
Sbjct: 1567 HKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL-ESHSTVLAREL 1625

Query: 386  KLQVQE--ETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQR 443
            + + QE    R ++  +    E L  + +   R+ +EL+ Q+ +    E +R +R+    
Sbjct: 1626 QERDQEVKSQREQIEELQRQKEHLTQDLE---RRDQELMLQKERIQVLEDQR-TRQTKIL 1681

Query: 444  GKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCD 503
             +DL    L+ +  G    T  Q  ++R     A+    P K   A    LE  +L+  D
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQER-----AEEGKGPSK---AQRGSLEHMKLILRD 1733

Query: 504  LEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGL----PPEECDYLRQ 559
             E+E  V   +  +   QEL     D  ++ +  L  +   G T L      +E   L+Q
Sbjct: 1734 KEKE--VECQQEHIHELQELK----DQLEQQLQGLHRKV--GETSLLLSQREQEIVVLQQ 1785

Query: 560  EVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVW-MEECALSSVLQTHLREDHEGTIRG 618
            ++QE       K    + Q  +  + L ++DQ++  +++    +  Q    ++    ++G
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQG 1845

Query: 619  VLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQR 678
             L +   +T +     LQ H    R     LA+ G  +  L ++    +    ++ +   
Sbjct: 1846 ALEQ-AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL 1904

Query: 679  ALEQGSSQCLDEHQ---------WQLLRA--------LEA-RVLEEASRLEEEAQQTRLQ 720
            AL+Q  ++   EH+         W   +A        LEA R   ++SR +EEA + R +
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964

Query: 721  LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRD---DFKRTLMEA--- 774
              Q  L +A    Q  +QH+   + QA L  +  A+T +     D      R L EA   
Sbjct: 1965 ALQEALGKAHAALQGKEQHL---LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021

Query: 775  ----AVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQE 830
                  +        V +L QA  Q+   +   H++ + Q L+    +R++   +++KQ 
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELR--HQQEREQLLEKSLAQRVQENMIQEKQN 2079

Query: 831  LSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHA---------QQQQA 881
            L           G H++ + +   +  +++  L      Q+  L A          ++Q+
Sbjct: 2080 LGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS 2138

Query: 882  GVMDLLEAQLETQLQEAE 899
              +D LE +L+ +L+  +
Sbjct: 2139 LKLDSLEPRLQRELERLQ 2156



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 181/817 (22%), Positives = 309/817 (37%), Gaps = 140/817 (17%)

Query: 252  KSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLI 311
            + + EL Q         +E L+  +    +    +G  + +  T     K + E  E   
Sbjct: 1340 QGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESER 1399

Query: 312  DNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQ------- 364
            +  +A  +Q        V Q K        L  TL ER    E L    QEL+       
Sbjct: 1400 ERAQALQEQ----GELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQK 1455

Query: 365  -ALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLT 423
             AL+ L   + + +    ++  + Q+QE  +CR       LE L     ++ +++E+ LT
Sbjct: 1456 AALELLSLDLKKRNQE--VDLQQEQIQELEKCRSV-----LEHLP----MAVQEREQKLT 1504

Query: 424  QQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADP 483
             Q +   +         +++ ++     L HQ+       L  E++ +   ++     D 
Sbjct: 1505 VQREQIRE---------LEKDRETQRNVLEHQL-------LELEKKDQMIESQRGQVQDL 1548

Query: 484  EKFLEAFH----EVLERQRLMQCD---LEEEENVRATEAVVALCQELYFSTVDTFQKFVD 536
            +K L        E+ E    M+C    ++E E  R T+ V      L   T+D  ++  +
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVA-----LTHLTLDLEERSQE 1603

Query: 537  ALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR-----FRRQQWKLFQELLEQDQ 591
               LQ               L +E+QE    Q  KS R      +RQ+  L Q+L  +DQ
Sbjct: 1604 ---LQAQSSQIHDLESHSTVLARELQERD--QEVKSQREQIEELQRQKEHLTQDLERRDQ 1658

Query: 592  QVWMEECALSSV-----LQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQ-------GHD 639
            ++ +++  +  +      QT + E+    I+  L R  G    + R ++Q       G  
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL-RERGRELTTQRQLMQERAEEGKGPS 1717

Query: 640  LLLRSALR--RLALRGNALATLTQMRLSGKKHLLQELREQRALEQ---------GSSQCL 688
               R +L   +L LR        Q       H LQEL++Q  LEQ         G +  L
Sbjct: 1718 KAQRGSLEHMKLILRDKEKEVECQQE---HIHELQELKDQ--LEQQLQGLHRKVGETSLL 1772

Query: 689  DEHQWQLLRALEARVLE--EASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQ 746
               + Q +  L+ ++ E  E   L+E++ Q++L   QR LA+  +  + LQQ  + A GQ
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832

Query: 747  ALLVHARNAAT-----------KSRAKDRDDFK----RTLMEAAVESVYVT--------- 782
               V  +  A            K R  +  D K    R   E AVE   V          
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892

Query: 783  ---SAGVSRLVQAYYQQIGRIMEDHE--ERKLQHL------------KTLQGERMENYKL 825
               S    + + A  QQ     ++HE   R LQ              + L+  R E+   
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS 1952

Query: 826  RKKQELSNPSSGS--RTAGGAHETSQAVHQRMLSQQK--RFLAQFPVHQQMRLHAQQQQA 881
            R ++E +   + +     G AH   Q   Q +L Q +  R L       Q  L A Q  +
Sbjct: 1953 RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHS 2012

Query: 882  GVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLL---PAKRGLLEKPLRTKRKKP 938
              ++      E ++Q+ +  +  ++  L +      + L     +  LLEK L  + ++ 
Sbjct: 2013 RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072

Query: 939  LPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQESE 975
            + QE+ +LG    E+   G   S       L+Q+E E
Sbjct: 2073 MIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE 2109



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 141/579 (24%), Positives = 229/579 (39%), Gaps = 85/579 (14%)

Query: 405 ELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTL 464
           EL+  E  LS   +EE L+ Q     Q  +  ++  V+ G ++   S  H+         
Sbjct: 322 ELMEHEASLSRNAQEEKLSLQ-----QVIKDITQVMVEEGDNIAQGS-GHE--------- 366

Query: 465 AQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELY 524
               E  S +       D +K L     VL R+R    DL ++  +   +  V L Q+ +
Sbjct: 367 -NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQ--LAGCQEAVNLLQQQH 423

Query: 525 FSTVDT-------FQKFV---DALFLQT--LPGMTGLPPEECDYLRQ---------EVQE 563
               +         QK     D L  QT  L G      +E + L++         EV E
Sbjct: 424 DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483

Query: 564 NAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLRE---DHEGTIRGVL 620
             AW+L + N   + Q    Q   E+ Q    EE  L+   +  L+E     E      L
Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQ----EELHLAVRERERLQEMLMGLEAKQSESL 539

Query: 621 GRLGGLTEESTRCVLQGHDLL-----LRSALRR-------LALRGNALAT-LTQMRLSGK 667
             L  L E      L+G  L      + +AL R       L+   N L T +  +R +  
Sbjct: 540 SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV 599

Query: 668 KHLLQELREQRALEQ-GSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLL 726
           K  L  L E  AL++ G +Q       QLL+ LE       SR+E  A+Q R  LQ  L 
Sbjct: 600 K--LSALNEALALDKVGLNQ-------QLLQ-LEEENQSVCSRMEA-AEQARNALQVDL- 647

Query: 727 AEAQEVGQLLQQ---HMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTS 783
           AEA++  + L +   H+E  + +A       A  ++  +D  + K  + +   ES +   
Sbjct: 648 AEAEKRREALWEKNTHLEAQLQKA---EEAGAELQADLRDIQEEKEEIQKKLSESRHQQE 704

Query: 784 AGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERME-NYKL----RKKQELSNPSSGS 838
           A  ++L Q +  Q  +  E+   R +Q  + L  E+     +L    R +Q+L+    G 
Sbjct: 705 AATTQLEQLH--QEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762

Query: 839 RTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEA 898
            +A    E+S    Q+  S  +    Q  V  Q    A++   G +  L+ +L+T+  +A
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822

Query: 899 EQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKK 937
           EQ   +    LA+        L  ++   EK +   R+K
Sbjct: 823 EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK 861



 Score = 38.9 bits (89), Expect = 0.024
 Identities = 129/618 (20%), Positives = 230/618 (37%), Gaps = 123/618 (19%)

Query: 247  LLPKKKSDDELYQKILSKQEKDLEELEK---GLQVKLSNTEMS-GAGDSEYITLADVEKK 302
            +L  K+ + E  Q+ + + ++  ++LE+   GL  K+  T +     + E + L    ++
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789

Query: 303  EREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQE 362
             RE  E    ++++            +D+ + + ++  Q +  L +    A+G   + + 
Sbjct: 1790 AREQGELKEQSLQS-----------QLDEAQRALAQRDQELEALQQEQQQAQGQ--EERV 1836

Query: 363  LQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLA---AIS----HGLELLAGEGKLSG 415
             +  DAL+  + +AHM       +LQ  +E   RL    A+       LE + G+ +   
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896

Query: 416  RQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLA 475
            R++E+ L    +   ++A+    E  +  +D    + A   E   +L   + E Q S   
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVE-TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQ 1955

Query: 476  EAQPTADPEKFLEAF---HEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQ 532
            E    A  E   EA    H  L+ +   Q  LE+ E  R+ EA  A  Q    +     +
Sbjct: 1956 EEAARARAEALQEALGKAHAALQGKE--QHLLEQAELSRSLEASTATLQASLDACQAHSR 2013

Query: 533  KFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQ 592
            +  +AL +Q      G   ++    +++VQ+       +    R QQ +  ++LLE+   
Sbjct: 2014 QLEEALRIQE-----GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQER--EQLLEKSLA 2066

Query: 593  VWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALR 652
              ++E  +    Q   +E  E  IRG                       L  ++R L   
Sbjct: 2067 QRVQENMIQEK-QNLGQEREEEEIRG-----------------------LHQSVREL--- 2099

Query: 653  GNALATLTQMRLSGKKHLLQELREQR------ALEQGSSQCLDEHQWQLLRALEARVLEE 706
                    Q+ L+ K+  + ELRE +      AL         E Q   L +LE R+  E
Sbjct: 2100 --------QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRE 2151

Query: 707  ASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              RL+   +QT                                  AR    + +A+D   
Sbjct: 2152 LERLQAALRQTE---------------------------------AREIEWREKAQD--- 2175

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQ-AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKL 825
                       S+  T A VS L + A + Q   +  D E+++LQ    L    +E  +L
Sbjct: 2176 --------LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227

Query: 826  RKKQELSNPSSGSRTAGG 843
                  S    GSR   G
Sbjct: 2228 HSPGATSTAELGSRGEQG 2245


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 160/698 (22%), Positives = 291/698 (41%), Gaps = 122/698 (17%)

Query: 250 KKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQ 309
           ++K D+E+      K+ + LE  + GL+ +L   E      S    L +  K E + S +
Sbjct: 372 QRKLDEEV------KKRQKLEPSQVGLERQL---EEKTEECSRLQELLERRKGEAQQSNK 422

Query: 310 LIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDAL 369
            + NM+    Q  +++H L  Q           +M L  ++   +G    ++E+   D L
Sbjct: 423 ELQNMKRLLDQGEDLRHGLETQ-----------VMELQNKLKHVQGPE-PAKEVLLKDLL 470

Query: 370 ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAF 429
           E    R  + +V+E  K +V+E+ R R   ++           L G  KEE+ ++  +  
Sbjct: 471 ET---RELLEEVLEG-KQRVEEQLRLRERELT----------ALKGALKEEVASRDQEVE 516

Query: 430 WQEAERFSREFVQRGKDLVTASLAHQV--EGTAKLTLAQEEEQRSFLAEAQPTADPEKFL 487
               +++ R+  Q  + +  A+  H V      K++      QR     ++ T   +   
Sbjct: 517 -HVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF 575

Query: 488 EAFHEVLE--RQRLMQCDLEEEE-NVRATEAVVALCQELY---FSTVDTFQKFVDALFLQ 541
           +   E L   +Q L+Q  +E+EE      E +  L +EL     S  DT Q  V+ L  +
Sbjct: 576 QKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQ--VEVLKKE 633

Query: 542 TLPGMTGLPPEECDYLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECAL 600
            L     L   + +   QEV   +   +L K     R +    +EL EQ+ Q       L
Sbjct: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQ-------L 686

Query: 601 SSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLT 660
              LQ  LR+D E   +  +        E+   VL      + + LR      +      
Sbjct: 687 QKTLQ-QLRQDCEEASKAKM------VAEAEATVLGQRRAAVETTLRETQEENDEF---- 735

Query: 661 QMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ 720
           + R+ G   L Q+L+E R L  G              A+EAR+ ++  RLE E Q    Q
Sbjct: 736 RRRILG---LEQQLKETRGLVDGGE------------AVEARLRDKLQRLEAEKQ----Q 776

Query: 721 LQQRLLAEAQEVGQL--LQQHMECAIGQALLVHAR---NAATKSRAKDRDDFKRTLMEAA 775
           L++ L A  +E G L   ++ +E  + +A    AR      T +RA + +  +R ++   
Sbjct: 777 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRG 836

Query: 776 VESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSN-- 833
              +      + R V    +++ +I ED +    Q L+ LQ + +E+YK + ++E+++  
Sbjct: 837 KAELEEQKRLLDRTVDRLNKELEKIGEDSK----QALQQLQAQ-LEDYKEKARREVADAQ 891

Query: 834 ------PSSGSRTAGG-------------AHETSQA------VHQRMLSQQKRFLAQFPV 868
                  S   +T+GG             A + SQA      + + +L+Q+ + L Q   
Sbjct: 892 RQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAE 951

Query: 869 HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISEL 906
           +++     + +Q   ++   ++LET+L E E+N +  L
Sbjct: 952 NKKRSQDDRARQLKGLEEKVSRLETELDE-EKNTVELL 988


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)

Query: 291  SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
            S+YI     TL  +E++ER   +Q  +  E    ++A ++  L  Q + + +        
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1386

Query: 338  --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
              +A++L   + E ++  E    D+Q        ELQ L   +      +A  A+  E  
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446

Query: 386  KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
            +L+++EE R  RL   +   +    EG+L   R + E    Q +   +EAER  R+    
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 444  G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
               K      LA +V+  A+   A  E+QR+  A  +     E+      +  +ER R +
Sbjct: 1507 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563

Query: 501  QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
            Q  LE  +  R+ EA +   +  +       ++      V    L+           E +
Sbjct: 1564 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621

Query: 556  YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
              R+E + E   WQL K+N   R + +  +E+ +Q      E        +   R   + 
Sbjct: 1622 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679

Query: 615  TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
              + V  R L     E  R + +G      +A +RLA       L   T+     ++ L 
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733

Query: 672  QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
            +EL   +     ++Q   E + +L  +RA    +L   +R EEE++ T  + +QRL AEA
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793

Query: 730  QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
                +L +   E A  +AL   A   R  A +  A+ R + +R L E  AA+       T
Sbjct: 1794 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850

Query: 783  SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
             A ++ +  +A  +++ R+ ED        EE+  QH   ++ ER+   +     EL   
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1906

Query: 835  SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
                R  G   +T    + V + +L+ +  F        ++ L   + ++   D L ++ 
Sbjct: 1907 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 892  ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
            + +L+ A Q    +LAA            + +   AE +    ++  LE+  R K K   
Sbjct: 1964 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2017

Query: 940  PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
             +E   L     ++ A   Q +   + KRL  +E
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
            + K  QL  +L E  +A   L  +  E +A    E    R    + +E  +L+  E  R 
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
            RL A     E +A +  L+  + E+    Q +   +EA R  +  E   R ++L    L 
Sbjct: 1645 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1695

Query: 454  HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
             Q    EGTA+  LA E+E     AE +      + LE     L+R+        +E   
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755

Query: 508  --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
                VRA   V+    A  +E   ST +  ++ ++A    F +       L    EE   
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815

Query: 557  LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
             RQ  +E+AA Q  ++ R   ++     E   L+ + ++ ++E    +     L ED   
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 612  -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
                       H+  I   L +L            GL E++ R   Q   ++L   A   
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
             A  G A   L   R+          +EQ  LE    + L   + +  R  E RV +  +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995

Query: 709  RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              EE A+Q +  L++  RL A+ +E  +L ++  + +  Q  L                 
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2040

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
                  EAA + +       +  VQ             +E++LQ  +TLQ E+    +LR
Sbjct: 2041 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2080

Query: 827  KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
             + E       +R A    E ++   +R  +Q +R + +    +Q      Q +A     
Sbjct: 2081 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134

Query: 887  LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
             E   +   QEA +   +E AAL +   A++++   K+   E+ LR K
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2181



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)

Query: 231  EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
            EKH  F +        L  K + + EL    L  +E D ++  L++ LQ +K   TE + 
Sbjct: 2168 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2221

Query: 288  AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
                    L  V  +  E S+       +N     +   N Q FL ++    + K +Q+ 
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2277

Query: 344  MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
                   +AA+    ++  L+ L   +    RA   K+++     VQE TR +  A    
Sbjct: 2278 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2329

Query: 404  LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
                            ELL QQ +   ++A R     +Q  K+ +   LA + +G  +  
Sbjct: 2330 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2368

Query: 464  LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
             A+ + Q    AEA                 ER +L   ++       EE+  R  +   
Sbjct: 2369 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 518  ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
             + ++L+ + + T +K      +QTL         + + LR+ + E     L +     +
Sbjct: 2412 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2463

Query: 578  QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
            Q+ KL Q   E+ Q V  E+          L+E                T+   +  L  
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2498

Query: 638  HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
             D LL+   R +      L  L Q  ++  + L +E  R+Q+ +EQ   + +   +    
Sbjct: 2499 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557

Query: 697  RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
            R  EA   E   R +EE QQ   Q +Q+  LLAE     +E  QLL++    A+  +  V
Sbjct: 2558 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615

Query: 751  HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
             A   AATK+    RD       EA  E  +    G+ R V A   Q   I+   E ++L
Sbjct: 2616 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2672



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
            +D   +K+S  E  Q++    E +++   K  Q + +        +   +    +E  ER
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1466

Query: 305  EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
            +               +  EA  +Q       L  Q +  S + RQ  + L  R+ A AE
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 355  GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
                  + LQAL+ L    E    R   A+V    ++QV  ET  R A      EL +  
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1582

Query: 411  GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
               + +  Q E  L ++H A  Q   EAER +++  +  R ++     L   Q++    L
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642

Query: 463  TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
             L   A+E  Q+  LA+A+     E   EA  E       E Q + Q +L E+E  +  +
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 515  AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
                  Q+   +  +  +     L  +T  G       E +  R + +  AA Q  +   
Sbjct: 1700 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754

Query: 575  FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
                + +   E+L   +    EE   +S       E   G  R +     RL  L EE+ 
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814

Query: 632  RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
            R   L   D   + A        +LA  G A  L T  ++ L  K+   + LR       
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874

Query: 676  -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
             ++R LE+ ++Q    ++E   QL +A ++  LE    L E+  + R Q+++ +LA   +
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1933

Query: 730  QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
             E     +  +E  +G+       NA    R+K++ +     +EAA +          R 
Sbjct: 1934 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1984

Query: 790  VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
                  Q     E+   R+    L+ ++ L+ +  E  +LR++ E         +A    
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2037

Query: 846  ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
               +A  +R+ +++K         +Q      QQ+  V+D L  + E   + AE+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
            ++ L K K+  E   + L  ++KD       EE EK  QV      +S A         +
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296

Query: 295  TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
               D+ ++     + L + M+A  +  ++      L  Q + +  +AR+L     ++   
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2353

Query: 353  AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
            A+ L  ++Q  Q     ER   +  M+   E LKL+V E +R +  A            +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412

Query: 413  LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
            +  +  + EL TQ+     Q                     E ER   +  Q  K L   
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472

Query: 451  SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
            S   Q     +L    +  Q+SFL+E       E+F+E   A  E L +  + +     E
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 508  ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
            E  R  + +    Q L  S  +  ++  +A              EE   L Q+ ++    
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2585

Query: 568  QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
             L + N+  R+Q +L +E     L   ++V   + A +  L            +      
Sbjct: 2586 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645

Query: 612  HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
             +G  R V    L   G L+ E  + + QGH   D L R    R  L+G +      ++ 
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2705

Query: 665  SGKKHLLQELREQRALEQGSSQCLDEHQ 692
            + +K  +    +++ L  G++  L E Q
Sbjct: 2706 TNEKLSVYAALQRQLLSPGTALILLEAQ 2733


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)

Query: 291  SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
            S+YI     TL  +E++ER   +Q  +  E    ++A ++  L  Q + + +        
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1390

Query: 338  --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
              +A++L   + E ++  E    D+Q        ELQ L   +      +A  A+  E  
Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1450

Query: 386  KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
            +L+++EE R  RL   +   +    EG+L   R + E    Q +   +EAER  R+    
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510

Query: 444  G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
               K      LA +V+  A+   A  E+QR+  A  +     E+      +  +ER R +
Sbjct: 1511 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1567

Query: 501  QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
            Q  LE  +  R+ EA +   +  +       ++      V    L+           E +
Sbjct: 1568 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1625

Query: 556  YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
              R+E + E   WQL K+N   R + +  +E+ +Q      E        +   R   + 
Sbjct: 1626 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683

Query: 615  TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
              + V  R L     E  R + +G      +A +RLA       L   T+     ++ L 
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737

Query: 672  QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
            +EL   +     ++Q   E + +L  +RA    +L   +R EEE++ T  + +QRL AEA
Sbjct: 1738 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1797

Query: 730  QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
                +L +   E A  +AL   A   R  A +  A+ R + +R L E  AA+       T
Sbjct: 1798 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1854

Query: 783  SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
             A ++ +  +A  +++ R+ ED        EE+  QH   ++ ER+   +     EL   
Sbjct: 1855 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1910

Query: 835  SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
                R  G   +T    + V + +L+ +  F        ++ L   + ++   D L ++ 
Sbjct: 1911 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967

Query: 892  ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
            + +L+ A Q    +LAA            + +   AE +    ++  LE+  R K K   
Sbjct: 1968 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2021

Query: 940  PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
             +E   L     ++ A   Q +   + KRL  +E
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
            + K  QL  +L E  +A   L  +  E +A    E    R    + +E  +L+  E  R 
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1648

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
            RL A     E +A +  L+  + E+    Q +   +EA R  +  E   R ++L    L 
Sbjct: 1649 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1699

Query: 454  HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
             Q    EGTA+  LA E+E     AE +      + LE     L+R+        +E   
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759

Query: 508  --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
                VRA   V+    A  +E   ST +  ++ ++A    F +       L    EE   
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1819

Query: 557  LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
             RQ  +E+AA Q  ++ R   ++     E   L+ + ++ ++E    +     L ED   
Sbjct: 1820 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879

Query: 612  -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
                       H+  I   L +L            GL E++ R   Q   ++L   A   
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
             A  G A   L   R+          +EQ  LE    + L   + +  R  E RV +  +
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999

Query: 709  RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              EE A+Q +  L++  RL A+ +E  +L ++  + +  Q  L                 
Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2044

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
                  EAA + +       +  VQ             +E++LQ  +TLQ E+    +LR
Sbjct: 2045 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2084

Query: 827  KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
             + E       +R A    E ++   +R  +Q +R + +    +Q      Q +A     
Sbjct: 2085 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138

Query: 887  LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
             E   +   QEA +   +E AAL +   A++++   K+   E+ LR K
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2185



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)

Query: 231  EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
            EKH  F +        L  K + + EL    L  +E D ++  L++ LQ +K   TE + 
Sbjct: 2172 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2225

Query: 288  AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
                    L  V  +  E S+       +N     +   N Q FL ++    + K +Q+ 
Sbjct: 2226 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2281

Query: 344  MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
                   +AA+    ++  L+ L   +    RA   K+++     VQE TR +  A    
Sbjct: 2282 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2333

Query: 404  LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
                            ELL QQ +   ++A R     +Q  K+ +   LA + +G  +  
Sbjct: 2334 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2372

Query: 464  LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
             A+ + Q    AEA                 ER +L   ++       EE+  R  +   
Sbjct: 2373 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415

Query: 518  ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
             + ++L+ + + T +K      +QTL         + + LR+ + E     L +     +
Sbjct: 2416 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2467

Query: 578  QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
            Q+ KL Q   E+ Q V  E+          L+E                T+   +  L  
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2502

Query: 638  HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
             D LL+   R +      L  L Q  ++  + L +E  R+Q+ +EQ   + +   +    
Sbjct: 2503 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561

Query: 697  RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
            R  EA   E   R +EE QQ   Q +Q+  LLAE     +E  QLL++    A+  +  V
Sbjct: 2562 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619

Query: 751  HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
             A   AATK+    RD       EA  E  +    G+ R V A   Q   I+   E ++L
Sbjct: 2620 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2676



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
            +D   +K+S  E  Q++    E +++   K  Q + +        +   +    +E  ER
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1470

Query: 305  EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
            +               +  EA  +Q       L  Q +  S + RQ  + L  R+ A AE
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530

Query: 355  GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
                  + LQAL+ L    E    R   A+V    ++QV  ET  R A      EL +  
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1586

Query: 411  GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
               + +  Q E  L ++H A  Q   EAER +++  +  R ++     L   Q++    L
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646

Query: 463  TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
             L   A+E  Q+  LA+A+     E   EA  E       E Q + Q +L E+E  +  +
Sbjct: 1647 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703

Query: 515  AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
                  Q+   +  +  +     L  +T  G       E +  R + +  AA Q  +   
Sbjct: 1704 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758

Query: 575  FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
                + +   E+L   +    EE   +S       E   G  R +     RL  L EE+ 
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818

Query: 632  RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
            R   L   D   + A        +LA  G A  L T  ++ L  K+   + LR       
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878

Query: 676  -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
             ++R LE+ ++Q    ++E   QL +A ++  LE    L E+  + R Q+++ +LA   +
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1937

Query: 730  QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
             E     +  +E  +G+       NA    R+K++ +     +EAA +          R 
Sbjct: 1938 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1988

Query: 790  VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
                  Q     E+   R+    L+ ++ L+ +  E  +LR++ E         +A    
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2041

Query: 846  ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
               +A  +R+ +++K         +Q      QQ+  V+D L  + E   + AE+
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
            ++ L K K+  E   + L  ++KD       EE EK  QV      +S A         +
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300

Query: 295  TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
               D+ ++     + L + M+A  +  ++      L  Q + +  +AR+L     ++   
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2357

Query: 353  AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
            A+ L  ++Q  Q     ER   +  M+   E LKL+V E +R +  A            +
Sbjct: 2358 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416

Query: 413  LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
            +  +  + EL TQ+     Q                     E ER   +  Q  K L   
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476

Query: 451  SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
            S   Q     +L    +  Q+SFL+E       E+F+E   A  E L +  + +     E
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536

Query: 508  ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
            E  R  + +    Q L  S  +  ++  +A              EE   L Q+ ++    
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2589

Query: 568  QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
             L + N+  R+Q +L +E     L   ++V   + A +  L            +      
Sbjct: 2590 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2649

Query: 612  HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
             +G  R V    L   G L+ E  + + QGH   D L R    R  L+G +      ++ 
Sbjct: 2650 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2709

Query: 665  SGKKHLLQELREQRALEQGSSQCLDEHQ 692
            + +K  +    +++ L  G++  L E Q
Sbjct: 2710 TNEKLSVYAALQRQLLSPGTALILLEAQ 2737


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)

Query: 291  SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
            S+YI     TL  +E++ER   +Q  +  E    ++A ++  L  Q + + +        
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1386

Query: 338  --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
              +A++L   + E ++  E    D+Q        ELQ L   +      +A  A+  E  
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446

Query: 386  KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
            +L+++EE R  RL   +   +    EG+L   R + E    Q +   +EAER  R+    
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 444  G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
               K      LA +V+  A+   A  E+QR+  A  +     E+      +  +ER R +
Sbjct: 1507 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563

Query: 501  QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
            Q  LE  +  R+ EA +   +  +       ++      V    L+           E +
Sbjct: 1564 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621

Query: 556  YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
              R+E + E   WQL K+N   R + +  +E+ +Q      E        +   R   + 
Sbjct: 1622 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679

Query: 615  TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
              + V  R L     E  R + +G      +A +RLA       L   T+     ++ L 
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733

Query: 672  QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
            +EL   +     ++Q   E + +L  +RA    +L   +R EEE++ T  + +QRL AEA
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793

Query: 730  QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
                +L +   E A  +AL   A   R  A +  A+ R + +R L E  AA+       T
Sbjct: 1794 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850

Query: 783  SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
             A ++ +  +A  +++ R+ ED        EE+  QH   ++ ER+   +     EL   
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1906

Query: 835  SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
                R  G   +T    + V + +L+ +  F        ++ L   + ++   D L ++ 
Sbjct: 1907 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 892  ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
            + +L+ A Q    +LAA            + +   AE +    ++  LE+  R K K   
Sbjct: 1964 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2017

Query: 940  PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
             +E   L     ++ A   Q +   + KRL  +E
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
            + K  QL  +L E  +A   L  +  E +A    E    R    + +E  +L+  E  R 
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
            RL A     E +A +  L+  + E+    Q +   +EA R  +  E   R ++L    L 
Sbjct: 1645 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1695

Query: 454  HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
             Q    EGTA+  LA E+E     AE +      + LE     L+R+        +E   
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755

Query: 508  --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
                VRA   V+    A  +E   ST +  ++ ++A    F +       L    EE   
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815

Query: 557  LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
             RQ  +E+AA Q  ++ R   ++     E   L+ + ++ ++E    +     L ED   
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 612  -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
                       H+  I   L +L            GL E++ R   Q   ++L   A   
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
             A  G A   L   R+          +EQ  LE    + L   + +  R  E RV +  +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995

Query: 709  RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              EE A+Q +  L++  RL A+ +E  +L ++  + +  Q  L                 
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2040

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
                  EAA + +       +  VQ             +E++LQ  +TLQ E+    +LR
Sbjct: 2041 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2080

Query: 827  KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
             + E       +R A    E ++   +R  +Q +R + +    +Q      Q +A     
Sbjct: 2081 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134

Query: 887  LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
             E   +   QEA +   +E AAL +   A++++   K+   E+ LR K
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2181



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)

Query: 231  EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
            EKH  F +        L  K + + EL    L  +E D ++  L++ LQ +K   TE + 
Sbjct: 2168 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2221

Query: 288  AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
                    L  V  +  E S+       +N     +   N Q FL ++    + K +Q+ 
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2277

Query: 344  MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
                   +AA+    ++  L+ L   +    RA   K+++     VQE TR +  A    
Sbjct: 2278 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2329

Query: 404  LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
                            ELL QQ +   ++A R     +Q  K+ +   LA + +G  +  
Sbjct: 2330 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2368

Query: 464  LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
             A+ + Q    AEA                 ER +L   ++       EE+  R  +   
Sbjct: 2369 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 518  ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
             + ++L+ + + T +K      +QTL         + + LR+ + E     L +     +
Sbjct: 2412 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2463

Query: 578  QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
            Q+ KL Q   E+ Q V  E+          L+E                T+   +  L  
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2498

Query: 638  HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
             D LL+   R +      L  L Q  ++  + L +E  R+Q+ +EQ   + +   +    
Sbjct: 2499 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557

Query: 697  RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
            R  EA   E   R +EE QQ   Q +Q+  LLAE     +E  QLL++    A+  +  V
Sbjct: 2558 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615

Query: 751  HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
             A   AATK+    RD       EA  E  +    G+ R V A   Q   I+   E ++L
Sbjct: 2616 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2672



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
            +D   +K+S  E  Q++    E +++   K  Q + +        +   +    +E  ER
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1466

Query: 305  EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
            +               +  EA  +Q       L  Q +  S + RQ  + L  R+ A AE
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 355  GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
                  + LQAL+ L    E    R   A+V    ++QV  ET  R A      EL +  
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1582

Query: 411  GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
               + +  Q E  L ++H A  Q   EAER +++  +  R ++     L   Q++    L
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642

Query: 463  TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
             L   A+E  Q+  LA+A+     E   EA  E       E Q + Q +L E+E  +  +
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 515  AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
                  Q+   +  +  +     L  +T  G       E +  R + +  AA Q  +   
Sbjct: 1700 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754

Query: 575  FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
                + +   E+L   +    EE   +S       E   G  R +     RL  L EE+ 
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814

Query: 632  RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
            R   L   D   + A        +LA  G A  L T  ++ L  K+   + LR       
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874

Query: 676  -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
             ++R LE+ ++Q    ++E   QL +A ++  LE    L E+  + R Q+++ +LA   +
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1933

Query: 730  QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
             E     +  +E  +G+       NA    R+K++ +     +EAA +          R 
Sbjct: 1934 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1984

Query: 790  VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
                  Q     E+   R+    L+ ++ L+ +  E  +LR++ E         +A    
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2037

Query: 846  ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
               +A  +R+ +++K         +Q      QQ+  V+D L  + E   + AE+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
            ++ L K K+  E   + L  ++KD       EE EK  QV      +S A         +
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296

Query: 295  TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
               D+ ++     + L + M+A  +  ++      L  Q + +  +AR+L     ++   
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2353

Query: 353  AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
            A+ L  ++Q  Q     ER   +  M+   E LKL+V E +R +  A            +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412

Query: 413  LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
            +  +  + EL TQ+     Q                     E ER   +  Q  K L   
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472

Query: 451  SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
            S   Q     +L    +  Q+SFL+E       E+F+E   A  E L +  + +     E
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 508  ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
            E  R  + +    Q L  S  +  ++  +A              EE   L Q+ ++    
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2585

Query: 568  QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
             L + N+  R+Q +L +E     L   ++V   + A +  L            +      
Sbjct: 2586 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645

Query: 612  HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
             +G  R V    L   G L+ E  + + QGH   D L R    R  L+G +      ++ 
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2705

Query: 665  SGKKHLLQELREQRALEQGSSQCLDEHQ 692
            + +K  +    +++ L  G++  L E Q
Sbjct: 2706 TNEKLSVYAALQRQLLSPGTALILLEAQ 2733


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)

Query: 291  SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
            S+YI     TL  +E++ER   +Q  +  E    ++A ++  L  Q + + +        
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1354

Query: 338  --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
              +A++L   + E ++  E    D+Q        ELQ L   +      +A  A+  E  
Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1414

Query: 386  KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
            +L+++EE R  RL   +   +    EG+L   R + E    Q +   +EAER  R+    
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474

Query: 444  G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
               K      LA +V+  A+   A  E+QR+  A  +     E+      +  +ER R +
Sbjct: 1475 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1531

Query: 501  QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
            Q  LE  +  R+ EA +   +  +       ++      V    L+           E +
Sbjct: 1532 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1589

Query: 556  YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
              R+E + E   WQL K+N   R + +  +E+ +Q      E        +   R   + 
Sbjct: 1590 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647

Query: 615  TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
              + V  R L     E  R + +G      +A +RLA       L   T+     ++ L 
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701

Query: 672  QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
            +EL   +     ++Q   E + +L  +RA    +L   +R EEE++ T  + +QRL AEA
Sbjct: 1702 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1761

Query: 730  QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
                +L +   E A  +AL   A   R  A +  A+ R + +R L E  AA+       T
Sbjct: 1762 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1818

Query: 783  SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
             A ++ +  +A  +++ R+ ED        EE+  QH   ++ ER+   +     EL   
Sbjct: 1819 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1874

Query: 835  SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
                R  G   +T    + V + +L+ +  F        ++ L   + ++   D L ++ 
Sbjct: 1875 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931

Query: 892  ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
            + +L+ A Q    +LAA            + +   AE +    ++  LE+  R K K   
Sbjct: 1932 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 1985

Query: 940  PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
             +E   L     ++ A   Q +   + KRL  +E
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
            + K  QL  +L E  +A   L  +  E +A    E    R    + +E  +L+  E  R 
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1612

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
            RL A     E +A +  L+  + E+    Q +   +EA R  +  E   R ++L    L 
Sbjct: 1613 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1663

Query: 454  HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
             Q    EGTA+  LA E+E     AE +      + LE     L+R+        +E   
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723

Query: 508  --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
                VRA   V+    A  +E   ST +  ++ ++A    F +       L    EE   
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1783

Query: 557  LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
             RQ  +E+AA Q  ++ R   ++     E   L+ + ++ ++E    +     L ED   
Sbjct: 1784 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843

Query: 612  -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
                       H+  I   L +L            GL E++ R   Q   ++L   A   
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
             A  G A   L   R+          +EQ  LE    + L   + +  R  E RV +  +
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963

Query: 709  RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              EE A+Q +  L++  RL A+ +E  +L ++  + +  Q  L                 
Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2008

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
                  EAA + +       +  VQ             +E++LQ  +TLQ E+    +LR
Sbjct: 2009 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2048

Query: 827  KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
             + E       +R A    E ++   +R  +Q +R + +    +Q      Q +A     
Sbjct: 2049 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102

Query: 887  LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
             E   +   QEA +   +E AAL +   A++++   K+   E+ LR K
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2149



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)

Query: 231  EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
            EKH  F +        L  K + + EL    L  +E D ++  L++ LQ +K   TE + 
Sbjct: 2136 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2189

Query: 288  AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
                    L  V  +  E S+       +N     +   N Q FL ++    + K +Q+ 
Sbjct: 2190 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2245

Query: 344  MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
                   +AA+    ++  L+ L   +    RA   K+++     VQE TR +  A    
Sbjct: 2246 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2297

Query: 404  LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
                            ELL QQ +   ++A R     +Q  K+ +   LA + +G  +  
Sbjct: 2298 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2336

Query: 464  LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
             A+ + Q    AEA                 ER +L   ++       EE+  R  +   
Sbjct: 2337 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379

Query: 518  ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
             + ++L+ + + T +K      +QTL         + + LR+ + E     L +     +
Sbjct: 2380 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2431

Query: 578  QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
            Q+ KL Q   E+ Q V  E+          L+E                T+   +  L  
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2466

Query: 638  HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
             D LL+   R +      L  L Q  ++  + L +E  R+Q+ +EQ   + +   +    
Sbjct: 2467 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525

Query: 697  RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
            R  EA   E   R +EE QQ   Q +Q+  LLAE     +E  QLL++    A+  +  V
Sbjct: 2526 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583

Query: 751  HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
             A   AATK+    RD       EA  E  +    G+ R V A   Q   I+   E ++L
Sbjct: 2584 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2640



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
            +D   +K+S  E  Q++    E +++   K  Q + +        +   +    +E  ER
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1434

Query: 305  EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
            +               +  EA  +Q       L  Q +  S + RQ  + L  R+ A AE
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494

Query: 355  GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
                  + LQAL+ L    E    R   A+V    ++QV  ET  R A      EL +  
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1550

Query: 411  GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
               + +  Q E  L ++H A  Q   EAER +++  +  R ++     L   Q++    L
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610

Query: 463  TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
             L   A+E  Q+  LA+A+     E   EA  E       E Q + Q +L E+E  +  +
Sbjct: 1611 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667

Query: 515  AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
                  Q+   +  +  +     L  +T  G       E +  R + +  AA Q  +   
Sbjct: 1668 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722

Query: 575  FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
                + +   E+L   +    EE   +S       E   G  R +     RL  L EE+ 
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782

Query: 632  RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
            R   L   D   + A        +LA  G A  L T  ++ L  K+   + LR       
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842

Query: 676  -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
             ++R LE+ ++Q    ++E   QL +A ++  LE    L E+  + R Q+++ +LA   +
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1901

Query: 730  QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
             E     +  +E  +G+       NA    R+K++ +     +EAA +          R 
Sbjct: 1902 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1952

Query: 790  VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
                  Q     E+   R+    L+ ++ L+ +  E  +LR++ E         +A    
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2005

Query: 846  ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
               +A  +R+ +++K         +Q      QQ+  V+D L  + E   + AE+
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
            ++ L K K+  E   + L  ++KD       EE EK  QV      +S A         +
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264

Query: 295  TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
               D+ ++     + L + M+A  +  ++      L  Q + +  +AR+L     ++   
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2321

Query: 353  AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
            A+ L  ++Q  Q     ER   +  M+   E LKL+V E +R +  A            +
Sbjct: 2322 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380

Query: 413  LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
            +  +  + EL TQ+     Q                     E ER   +  Q  K L   
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440

Query: 451  SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
            S   Q     +L    +  Q+SFL+E       E+F+E   A  E L +  + +     E
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500

Query: 508  ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
            E  R  + +    Q L  S  +  ++  +A              EE   L Q+ ++    
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2553

Query: 568  QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
             L + N+  R+Q +L +E     L   ++V   + A +  L            +      
Sbjct: 2554 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2613

Query: 612  HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
             +G  R V    L   G L+ E  + + QGH   D L R    R  L+G +      ++ 
Sbjct: 2614 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2673

Query: 665  SGKKHLLQELREQRALEQGSSQCLDEHQ 692
            + +K  +    +++ L  G++  L E Q
Sbjct: 2674 TNEKLSVYAALQRQLLSPGTALILLEAQ 2701


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)

Query: 291  SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
            S+YI     TL  +E++ER   +Q  +  E    ++A ++  L  Q + + +        
Sbjct: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1523

Query: 338  --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
              +A++L   + E ++  E    D+Q        ELQ L   +      +A  A+  E  
Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1583

Query: 386  KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
            +L+++EE R  RL   +   +    EG+L   R + E    Q +   +EAER  R+    
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643

Query: 444  G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
               K      LA +V+  A+   A  E+QR+  A  +     E+      +  +ER R +
Sbjct: 1644 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1700

Query: 501  QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
            Q  LE  +  R+ EA +   +  +       ++      V    L+           E +
Sbjct: 1701 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1758

Query: 556  YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
              R+E + E   WQL K+N   R + +  +E+ +Q      E        +   R   + 
Sbjct: 1759 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816

Query: 615  TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
              + V  R L     E  R + +G      +A +RLA       L   T+     ++ L 
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870

Query: 672  QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
            +EL   +     ++Q   E + +L  +RA    +L   +R EEE++ T  + +QRL AEA
Sbjct: 1871 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1930

Query: 730  QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
                +L +   E A  +AL   A   R  A +  A+ R + +R L E  AA+       T
Sbjct: 1931 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1987

Query: 783  SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
             A ++ +  +A  +++ R+ ED        EE+  QH   ++ ER+   +     EL   
Sbjct: 1988 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 2043

Query: 835  SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
                R  G   +T    + V + +L+ +  F        ++ L   + ++   D L ++ 
Sbjct: 2044 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100

Query: 892  ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
            + +L+ A Q    +LAA            + +   AE +    ++  LE+  R K K   
Sbjct: 2101 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2154

Query: 940  PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
             +E   L     ++ A   Q +   + KRL  +E
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
            + K  QL  +L E  +A   L  +  E +A    E    R    + +E  +L+  E  R 
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1781

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
            RL A     E +A +  L+  + E+    Q +   +EA R  +  E   R ++L    L 
Sbjct: 1782 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1832

Query: 454  HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
             Q    EGTA+  LA E+E     AE +      + LE     L+R+        +E   
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892

Query: 508  --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
                VRA   V+    A  +E   ST +  ++ ++A    F +       L    EE   
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1952

Query: 557  LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
             RQ  +E+AA Q  ++ R   ++     E   L+ + ++ ++E    +     L ED   
Sbjct: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012

Query: 612  -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
                       H+  I   L +L            GL E++ R   Q   ++L   A   
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
             A  G A   L   R+          +EQ  LE    + L   + +  R  E RV +  +
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132

Query: 709  RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              EE A+Q +  L++  RL A+ +E  +L ++  + +  Q  L                 
Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2177

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
                  EAA + +       +  VQ             +E++LQ  +TLQ E+    +LR
Sbjct: 2178 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2217

Query: 827  KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
             + E       +R A    E ++   +R  +Q +R + +    +Q      Q +A     
Sbjct: 2218 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271

Query: 887  LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
             E   +   QEA +   +E AAL +   A++++   K+   E+ LR K
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2318



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)

Query: 231  EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
            EKH  F +        L  K + + EL    L  +E D ++  L++ LQ +K   TE + 
Sbjct: 2305 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2358

Query: 288  AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
                    L  V  +  E S+       +N     +   N Q FL ++    + K +Q+ 
Sbjct: 2359 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2414

Query: 344  MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
                   +AA+    ++  L+ L   +    RA   K+++     VQE TR +  A    
Sbjct: 2415 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2466

Query: 404  LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
                            ELL QQ +   ++A R     +Q  K+ +   LA + +G  +  
Sbjct: 2467 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2505

Query: 464  LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
             A+ + Q    AEA                 ER +L   ++       EE+  R  +   
Sbjct: 2506 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548

Query: 518  ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
             + ++L+ + + T +K      +QTL         + + LR+ + E     L +     +
Sbjct: 2549 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2600

Query: 578  QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
            Q+ KL Q   E+ Q V  E+          L+E                T+   +  L  
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2635

Query: 638  HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
             D LL+   R +      L  L Q  ++  + L +E  R+Q+ +EQ   + +   +    
Sbjct: 2636 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694

Query: 697  RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
            R  EA   E   R +EE QQ   Q +Q+  LLAE     +E  QLL++    A+  +  V
Sbjct: 2695 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752

Query: 751  HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
             A   AATK+    RD       EA  E  +    G+ R V A   Q   I+   E ++L
Sbjct: 2753 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2809



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
            +D   +K+S  E  Q++    E +++   K  Q + +        +   +    +E  ER
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1603

Query: 305  EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
            +               +  EA  +Q       L  Q +  S + RQ  + L  R+ A AE
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663

Query: 355  GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
                  + LQAL+ L    E    R   A+V    ++QV  ET  R A      EL +  
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1719

Query: 411  GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
               + +  Q E  L ++H A  Q   EAER +++  +  R ++     L   Q++    L
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779

Query: 463  TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
             L   A+E  Q+  LA+A+     E   EA  E       E Q + Q +L E+E  +  +
Sbjct: 1780 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836

Query: 515  AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
                  Q+   +  +  +     L  +T  G       E +  R + +  AA Q  +   
Sbjct: 1837 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891

Query: 575  FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
                + +   E+L   +    EE   +S       E   G  R +     RL  L EE+ 
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951

Query: 632  RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
            R   L   D   + A        +LA  G A  L T  ++ L  K+   + LR       
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011

Query: 676  -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
             ++R LE+ ++Q    ++E   QL +A ++  LE    L E+  + R Q+++ +LA   +
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 2070

Query: 730  QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
             E     +  +E  +G+       NA    R+K++ +     +EAA +          R 
Sbjct: 2071 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 2121

Query: 790  VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
                  Q     E+   R+    L+ ++ L+ +  E  +LR++ E         +A    
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2174

Query: 846  ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
               +A  +R+ +++K         +Q      QQ+  V+D L  + E   + AE+
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
            ++ L K K+  E   + L  ++KD       EE EK  QV      +S A         +
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433

Query: 295  TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
               D+ ++     + L + M+A  +  ++      L  Q + +  +AR+L     ++   
Sbjct: 2434 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2490

Query: 353  AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
            A+ L  ++Q  Q     ER   +  M+   E LKL+V E +R +  A            +
Sbjct: 2491 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549

Query: 413  LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
            +  +  + EL TQ+     Q                     E ER   +  Q  K L   
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609

Query: 451  SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
            S   Q     +L    +  Q+SFL+E       E+F+E   A  E L +  + +     E
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669

Query: 508  ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
            E  R  + +    Q L  S  +  ++  +A              EE   L Q+ ++    
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2722

Query: 568  QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
             L + N+  R+Q +L +E     L   ++V   + A +  L            +      
Sbjct: 2723 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2782

Query: 612  HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
             +G  R V    L   G L+ E  + + QGH   D L R    R  L+G +      ++ 
Sbjct: 2783 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2842

Query: 665  SGKKHLLQELREQRALEQGSSQCLDEHQ 692
            + +K  +    +++ L  G++  L E Q
Sbjct: 2843 TNEKLSVYAALQRQLLSPGTALILLEAQ 2870


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)

Query: 291  SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
            S+YI     TL  +E++ER   +Q  +  E    ++A ++  L  Q + + +        
Sbjct: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1364

Query: 338  --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
              +A++L   + E ++  E    D+Q        ELQ L   +      +A  A+  E  
Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1424

Query: 386  KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
            +L+++EE R  RL   +   +    EG+L   R + E    Q +   +EAER  R+    
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484

Query: 444  G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
               K      LA +V+  A+   A  E+QR+  A  +     E+      +  +ER R +
Sbjct: 1485 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1541

Query: 501  QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
            Q  LE  +  R+ EA +   +  +       ++      V    L+           E +
Sbjct: 1542 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1599

Query: 556  YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
              R+E + E   WQL K+N   R + +  +E+ +Q      E        +   R   + 
Sbjct: 1600 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657

Query: 615  TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
              + V  R L     E  R + +G      +A +RLA       L   T+     ++ L 
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711

Query: 672  QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
            +EL   +     ++Q   E + +L  +RA    +L   +R EEE++ T  + +QRL AEA
Sbjct: 1712 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1771

Query: 730  QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
                +L +   E A  +AL   A   R  A +  A+ R + +R L E  AA+       T
Sbjct: 1772 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1828

Query: 783  SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
             A ++ +  +A  +++ R+ ED        EE+  QH   ++ ER+   +     EL   
Sbjct: 1829 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1884

Query: 835  SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
                R  G   +T    + V + +L+ +  F        ++ L   + ++   D L ++ 
Sbjct: 1885 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941

Query: 892  ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
            + +L+ A Q    +LAA            + +   AE +    ++  LE+  R K K   
Sbjct: 1942 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 1995

Query: 940  PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
             +E   L     ++ A   Q +   + KRL  +E
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
            + K  QL  +L E  +A   L  +  E +A    E    R    + +E  +L+  E  R 
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1622

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
            RL A     E +A +  L+  + E+    Q +   +EA R  +  E   R ++L    L 
Sbjct: 1623 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1673

Query: 454  HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
             Q    EGTA+  LA E+E     AE +      + LE     L+R+        +E   
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733

Query: 508  --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
                VRA   V+    A  +E   ST +  ++ ++A    F +       L    EE   
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1793

Query: 557  LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
             RQ  +E+AA Q  ++ R   ++     E   L+ + ++ ++E    +     L ED   
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853

Query: 612  -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
                       H+  I   L +L            GL E++ R   Q   ++L   A   
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
             A  G A   L   R+          +EQ  LE    + L   + +  R  E RV +  +
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973

Query: 709  RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              EE A+Q +  L++  RL A+ +E  +L ++  + +  Q  L                 
Sbjct: 1974 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2018

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
                  EAA + +       +  VQ             +E++LQ  +TLQ E+    +LR
Sbjct: 2019 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2058

Query: 827  KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
             + E       +R A    E ++   +R  +Q +R + +    +Q      Q +A     
Sbjct: 2059 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112

Query: 887  LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
             E   +   QEA +   +E AAL +   A++++   K+   E+ LR K
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2159



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)

Query: 231  EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
            EKH  F +        L  K + + EL    L  +E D ++  L++ LQ +K   TE + 
Sbjct: 2146 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2199

Query: 288  AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
                    L  V  +  E S+       +N     +   N Q FL ++    + K +Q+ 
Sbjct: 2200 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2255

Query: 344  MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
                   +AA+    ++  L+ L   +    RA   K+++     VQE TR +  A    
Sbjct: 2256 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2307

Query: 404  LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
                            ELL QQ +   ++A R     +Q  K+ +   LA + +G  +  
Sbjct: 2308 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2346

Query: 464  LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
             A+ + Q    AEA                 ER +L   ++       EE+  R  +   
Sbjct: 2347 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389

Query: 518  ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
             + ++L+ + + T +K      +QTL         + + LR+ + E     L +     +
Sbjct: 2390 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2441

Query: 578  QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
            Q+ KL Q   E+ Q V  E+          L+E                T+   +  L  
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2476

Query: 638  HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
             D LL+   R +      L  L Q  ++  + L +E  R+Q+ +EQ   + +   +    
Sbjct: 2477 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535

Query: 697  RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
            R  EA   E   R +EE QQ   Q +Q+  LLAE     +E  QLL++    A+  +  V
Sbjct: 2536 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593

Query: 751  HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
             A   AATK+    RD       EA  E  +    G+ R V A   Q   I+   E ++L
Sbjct: 2594 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2650



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
            +D   +K+S  E  Q++    E +++   K  Q + +        +   +    +E  ER
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1444

Query: 305  EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
            +               +  EA  +Q       L  Q +  S + RQ  + L  R+ A AE
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504

Query: 355  GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
                  + LQAL+ L    E    R   A+V    ++QV  ET  R A      EL +  
Sbjct: 1505 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1560

Query: 411  GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
               + +  Q E  L ++H A  Q   EAER +++  +  R ++     L   Q++    L
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620

Query: 463  TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
             L   A+E  Q+  LA+A+     E   EA  E       E Q + Q +L E+E  +  +
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677

Query: 515  AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
                  Q+   +  +  +     L  +T  G       E +  R + +  AA Q  +   
Sbjct: 1678 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732

Query: 575  FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
                + +   E+L   +    EE   +S       E   G  R +     RL  L EE+ 
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792

Query: 632  RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
            R   L   D   + A        +LA  G A  L T  ++ L  K+   + LR       
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852

Query: 676  -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
             ++R LE+ ++Q    ++E   QL +A ++  LE    L E+  + R Q+++ +LA   +
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1911

Query: 730  QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
             E     +  +E  +G+       NA    R+K++ +     +EAA +          R 
Sbjct: 1912 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1962

Query: 790  VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
                  Q     E+   R+    L+ ++ L+ +  E  +LR++ E         +A    
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2015

Query: 846  ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
               +A  +R+ +++K         +Q      QQ+  V+D L  + E   + AE+
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
            ++ L K K+  E   + L  ++KD       EE EK  QV      +S A         +
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274

Query: 295  TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
               D+ ++     + L + M+A  +  ++      L  Q + +  +AR+L     ++   
Sbjct: 2275 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2331

Query: 353  AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
            A+ L  ++Q  Q     ER   +  M+   E LKL+V E +R +  A            +
Sbjct: 2332 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390

Query: 413  LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
            +  +  + EL TQ+     Q                     E ER   +  Q  K L   
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450

Query: 451  SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
            S   Q     +L    +  Q+SFL+E       E+F+E   A  E L +  + +     E
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510

Query: 508  ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
            E  R  + +    Q L  S  +  ++  +A              EE   L Q+ ++    
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2563

Query: 568  QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
             L + N+  R+Q +L +E     L   ++V   + A +  L            +      
Sbjct: 2564 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2623

Query: 612  HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
             +G  R V    L   G L+ E  + + QGH   D L R    R  L+G +      ++ 
Sbjct: 2624 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2683

Query: 665  SGKKHLLQELREQRALEQGSSQCLDEHQ 692
            + +K  +    +++ L  G++  L E Q
Sbjct: 2684 TNEKLSVYAALQRQLLSPGTALILLEAQ 2711


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)

Query: 291  SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
            S+YI     TL  +E++ER   +Q  +  E    ++A ++  L  Q + + +        
Sbjct: 1317 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1372

Query: 338  --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
              +A++L   + E ++  E    D+Q        ELQ L   +      +A  A+  E  
Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1432

Query: 386  KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
            +L+++EE R  RL   +   +    EG+L   R + E    Q +   +EAER  R+    
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492

Query: 444  G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
               K      LA +V+  A+   A  E+QR+  A  +     E+      +  +ER R +
Sbjct: 1493 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1549

Query: 501  QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
            Q  LE  +  R+ EA +   +  +       ++      V    L+           E +
Sbjct: 1550 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1607

Query: 556  YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
              R+E + E   WQL K+N   R + +  +E+ +Q      E        +   R   + 
Sbjct: 1608 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665

Query: 615  TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
              + V  R L     E  R + +G      +A +RLA       L   T+     ++ L 
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719

Query: 672  QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
            +EL   +     ++Q   E + +L  +RA    +L   +R EEE++ T  + +QRL AEA
Sbjct: 1720 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1779

Query: 730  QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
                +L +   E A  +AL   A   R  A +  A+ R + +R L E  AA+       T
Sbjct: 1780 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1836

Query: 783  SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
             A ++ +  +A  +++ R+ ED        EE+  QH   ++ ER+   +     EL   
Sbjct: 1837 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1892

Query: 835  SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
                R  G   +T    + V + +L+ +  F        ++ L   + ++   D L ++ 
Sbjct: 1893 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949

Query: 892  ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
            + +L+ A Q    +LAA            + +   AE +    ++  LE+  R K K   
Sbjct: 1950 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2003

Query: 940  PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
             +E   L     ++ A   Q +   + KRL  +E
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
            + K  QL  +L E  +A   L  +  E +A    E    R    + +E  +L+  E  R 
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1630

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
            RL A     E +A +  L+  + E+    Q +   +EA R  +  E   R ++L    L 
Sbjct: 1631 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1681

Query: 454  HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
             Q    EGTA+  LA E+E     AE +      + LE     L+R+        +E   
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741

Query: 508  --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
                VRA   V+    A  +E   ST +  ++ ++A    F +       L    EE   
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1801

Query: 557  LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
             RQ  +E+AA Q  ++ R   ++     E   L+ + ++ ++E    +     L ED   
Sbjct: 1802 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861

Query: 612  -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
                       H+  I   L +L            GL E++ R   Q   ++L   A   
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
             A  G A   L   R+          +EQ  LE    + L   + +  R  E RV +  +
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981

Query: 709  RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              EE A+Q +  L++  RL A+ +E  +L ++  + +  Q  L                 
Sbjct: 1982 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2026

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
                  EAA + +       +  VQ             +E++LQ  +TLQ E+    +LR
Sbjct: 2027 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2066

Query: 827  KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
             + E       +R A    E ++   +R  +Q +R + +    +Q      Q +A     
Sbjct: 2067 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120

Query: 887  LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
             E   +   QEA +   +E AAL +   A++++   K+   E+ LR K
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2167



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)

Query: 231  EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
            EKH  F +        L  K + + EL    L  +E D ++  L++ LQ +K   TE + 
Sbjct: 2154 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2207

Query: 288  AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
                    L  V  +  E S+       +N     +   N Q FL ++    + K +Q+ 
Sbjct: 2208 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2263

Query: 344  MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
                   +AA+    ++  L+ L   +    RA   K+++     VQE TR +  A    
Sbjct: 2264 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2315

Query: 404  LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
                            ELL QQ +   ++A R     +Q  K+ +   LA + +G  +  
Sbjct: 2316 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2354

Query: 464  LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
             A+ + Q    AEA                 ER +L   ++       EE+  R  +   
Sbjct: 2355 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397

Query: 518  ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
             + ++L+ + + T +K      +QTL         + + LR+ + E     L +     +
Sbjct: 2398 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2449

Query: 578  QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
            Q+ KL Q   E+ Q V  E+          L+E                T+   +  L  
Sbjct: 2450 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2484

Query: 638  HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
             D LL+   R +      L  L Q  ++  + L +E  R+Q+ +EQ   + +   +    
Sbjct: 2485 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543

Query: 697  RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
            R  EA   E   R +EE QQ   Q +Q+  LLAE     +E  QLL++    A+  +  V
Sbjct: 2544 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601

Query: 751  HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
             A   AATK+    RD       EA  E  +    G+ R V A   Q   I+   E ++L
Sbjct: 2602 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2658



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
            +D   +K+S  E  Q++    E +++   K  Q + +        +   +    +E  ER
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1452

Query: 305  EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
            +               +  EA  +Q       L  Q +  S + RQ  + L  R+ A AE
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512

Query: 355  GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
                  + LQAL+ L    E    R   A+V    ++QV  ET  R A      EL +  
Sbjct: 1513 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1568

Query: 411  GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
               + +  Q E  L ++H A  Q   EAER +++  +  R ++     L   Q++    L
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628

Query: 463  TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
             L   A+E  Q+  LA+A+     E   EA  E       E Q + Q +L E+E  +  +
Sbjct: 1629 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1685

Query: 515  AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
                  Q+   +  +  +     L  +T  G       E +  R + +  AA Q  +   
Sbjct: 1686 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740

Query: 575  FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
                + +   E+L   +    EE   +S       E   G  R +     RL  L EE+ 
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800

Query: 632  RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
            R   L   D   + A        +LA  G A  L T  ++ L  K+   + LR       
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860

Query: 676  -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
             ++R LE+ ++Q    ++E   QL +A ++  LE    L E+  + R Q+++ +LA   +
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1919

Query: 730  QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
             E     +  +E  +G+       NA    R+K++ +     +EAA +          R 
Sbjct: 1920 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 1970

Query: 790  VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
                  Q     E+   R+    L+ ++ L+ +  E  +LR++ E         +A    
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2023

Query: 846  ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
               +A  +R+ +++K         +Q      QQ+  V+D L  + E   + AE+
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
            ++ L K K+  E   + L  ++KD       EE EK  QV      +S A         +
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282

Query: 295  TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
               D+ ++     + L + M+A  +  ++      L  Q + +  +AR+L     ++   
Sbjct: 2283 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2339

Query: 353  AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
            A+ L  ++Q  Q     ER   +  M+   E LKL+V E +R +  A            +
Sbjct: 2340 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2398

Query: 413  LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
            +  +  + EL TQ+     Q                     E ER   +  Q  K L   
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458

Query: 451  SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
            S   Q     +L    +  Q+SFL+E       E+F+E   A  E L +  + +     E
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518

Query: 508  ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
            E  R  + +    Q L  S  +  ++  +A              EE   L Q+ ++    
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2571

Query: 568  QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
             L + N+  R+Q +L +E     L   ++V   + A +  L            +      
Sbjct: 2572 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2631

Query: 612  HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
             +G  R V    L   G L+ E  + + QGH   D L R    R  L+G +      ++ 
Sbjct: 2632 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2691

Query: 665  SGKKHLLQELREQRALEQGSSQCLDEHQ 692
            + +K  +    +++ L  G++  L E Q
Sbjct: 2692 TNEKLSVYAALQRQLLSPGTALILLEAQ 2719


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 170/754 (22%), Positives = 304/754 (40%), Gaps = 104/754 (13%)

Query: 291  SEYI-----TLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSS-------- 337
            S+YI     TL  +E++ER   +Q  +  E    ++A ++  L  Q + + +        
Sbjct: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERE----RLAEVEAALEKQRQLAEAHAQAKAQA 1413

Query: 338  --KARQLMMTLTERMIAAEGLLCDSQ--------ELQAL--DALERTMGRAHMAKVIEFL 385
              +A++L   + E ++  E    D+Q        ELQ L   +      +A  A+  E  
Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1473

Query: 386  KLQVQEETRC-RLAAISHGLELLAGEGKLSG-RQKEELLTQQHKAFWQEAERFSREFVQR 443
            +L+++EE R  RL   +   +    EG+L   R + E    Q +   +EAER  R+    
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533

Query: 444  G--KDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEV-LERQRLM 500
               K      LA +V+  A+   A  E+QR+  A  +     E+      +  +ER R +
Sbjct: 1534 SQRKRQAEVELASRVKAEAE---AAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1590

Query: 501  QCDLEEEENVRATEAVVALCQELYFSTVDTFQK-----FVDALFLQTLPGMTGLPPEECD 555
            Q  LE  +  R+ EA +   +  +       ++      V    L+           E +
Sbjct: 1591 QVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1648

Query: 556  YLRQEVQ-ENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEG 614
              R+E + E   WQL K+N   R + +  +E+ +Q      E        +   R   + 
Sbjct: 1649 RAREEAERELERWQL-KANEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706

Query: 615  TIRGVLGR-LGGLTEESTRCVLQGHDLLLRSALRRLALRGNA--LATLTQMRLSGKKHLL 671
              + V  R L     E  R + +G      +A +RLA       L   T+     ++ L 
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760

Query: 672  QELREQRALEQGSSQCLDEHQWQL--LRALEARVLEEASRLEEEAQQTRLQLQQRLLAEA 729
            +EL   +     ++Q   E + +L  +RA    +L   +R EEE++ T  + +QRL AEA
Sbjct: 1761 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1820

Query: 730  QEVGQLLQQHMECAIGQALLVHA---RNAATKSRAKDRDDFKRTLME--AAVESV--YVT 782
                +L +   E A  +AL   A   R  A +  A+ R + +R L E  AA+       T
Sbjct: 1821 GRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1877

Query: 783  SAGVS-RLVQAYYQQIGRIMEDH-------EERKLQHLKTLQGERMENYKLRKKQELSNP 834
             A ++ +  +A  +++ R+ ED        EE+  QH   ++ ER+   +     EL   
Sbjct: 1878 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSEL--- 1933

Query: 835  SSGSRTAGGAHET---SQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQL 891
                R  G   +T    + V + +L+ +  F        ++ L   + ++   D L ++ 
Sbjct: 1934 ---ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990

Query: 892  ETQLQEAEQNFISELAA------------LARVPLAESKLLPAKRGLLEKPLRTKRKKPL 939
            + +L+ A Q    +LAA            + +   AE +    ++  LE+  R K K   
Sbjct: 1991 QAELEAARQR---QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK--- 2044

Query: 940  PQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQE 973
             +E   L     ++ A   Q +   + KRL  +E
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 147/648 (22%), Positives = 248/648 (38%), Gaps = 101/648 (15%)

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
            + K  QL  +L E  +A   L  +  E +A    E    R    + +E  +L+  E  R 
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1671

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSR--EFVQRGKDLVTASLA 453
            RL A     E +A +  L+  + E+    Q +   +EA R  +  E   R ++L    L 
Sbjct: 1672 RLQA-----EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQAVRQRELAEQELE 1722

Query: 454  HQ---VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEE--- 507
             Q    EGTA+  LA E+E     AE +      + LE     L+R+        +E   
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782

Query: 508  --ENVRATEAVV----ALCQELYFSTVDTFQKFVDA---LFLQTLPGMTGLPP--EECDY 556
                VRA   V+    A  +E   ST +  ++ ++A    F +       L    EE   
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1842

Query: 557  LRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LEQDQQVWMEECALSSVLQTHLRED--- 611
             RQ  +E+AA Q  ++ R   ++     E   L+ + ++ ++E    +     L ED   
Sbjct: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902

Query: 612  -----------HEGTIRGVLGRLG-----------GLTEESTRCVLQ-GHDLLLRSALRR 648
                       H+  I   L +L            GL E++ R   Q   ++L   A   
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
             A  G A   L   R+          +EQ  LE    + L   + +  R  E RV +  +
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022

Query: 709  RLEEEAQQTRLQLQQ--RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDD 766
              EE A+Q +  L++  RL A+ +E  +L ++  + +  Q  L                 
Sbjct: 2023 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--------------- 2067

Query: 767  FKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLR 826
                  EAA + +       +  VQ             +E++LQ  +TLQ E+    +LR
Sbjct: 2068 ------EAAQKRLQAEEKAHAFAVQ------------QKEQELQ--QTLQQEQSVLDQLR 2107

Query: 827  KKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDL 886
             + E       +R A    E ++   +R  +Q +R + +    +Q      Q +A     
Sbjct: 2108 GEAE------AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161

Query: 887  LEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTK 934
             E   +   QEA +   +E AAL +   A++++   K+   E+ LR K
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQK 2208



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 138/600 (23%), Positives = 229/600 (38%), Gaps = 116/600 (19%)

Query: 231  EKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEE--LEKGLQ-VKLSNTEMSG 287
            EKH  F +        L  K + + EL    L  +E D ++  L++ LQ +K   TE + 
Sbjct: 2195 EKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2248

Query: 288  AGDSEYITLADVEKKEREYSEQLI----DNMEAFWKQMANIQHFLVDQFKCSSSKARQLM 343
                    L  V  +  E S+       +N     +   N Q FL ++    + K +Q+ 
Sbjct: 2249 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVA 2304

Query: 344  MTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHG 403
                   +AA+    ++  L+ L   +    RA   K+++     VQE TR +  A    
Sbjct: 2305 EEAARLSVAAQ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA---- 2356

Query: 404  LELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT 463
                            ELL QQ +   ++A R     +Q  K+ +   LA + +G  +  
Sbjct: 2357 ----------------ELLQQQKELAQEQARR-----LQEDKEQMAQQLAEETQGFQRTL 2395

Query: 464  LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE------EEENVRATEAVV 517
             A+ + Q    AEA                 ER +L   ++       EE+  R  +   
Sbjct: 2396 EAERQRQLEMSAEA-----------------ERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438

Query: 518  ALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRR 577
             + ++L+ + + T +K      +QTL         + + LR+ + E     L +     +
Sbjct: 2439 EIGEKLHRTELATQEKVT---LVQTLEIQRQQSDHDAERLREAIAE-----LEREKEKLQ 2490

Query: 578  QQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQG 637
            Q+ KL Q   E+ Q V  E+          L+E                T+   +  L  
Sbjct: 2491 QEAKLLQLKSEEMQTVQQEQL---------LQE----------------TQALQQSFLSE 2525

Query: 638  HDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL-REQRALEQGSSQCLDEHQWQLL 696
             D LL+   R +      L  L Q  ++  + L +E  R+Q+ +EQ   + +   +    
Sbjct: 2526 KDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584

Query: 697  RALEARVLEEASRLEEEAQQTRLQLQQR--LLAEA----QEVGQLLQQHMECAIGQALLV 750
            R  EA   E   R +EE QQ   Q +Q+  LLAE     +E  QLL++    A+  +  V
Sbjct: 2585 RQHEAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642

Query: 751  HARN-AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKL 809
             A   AATK+    RD       EA  E  +    G+ R V A   Q   I+   E ++L
Sbjct: 2643 TASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQEAGILSAEELQRL 2699



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 157/715 (21%), Positives = 276/715 (38%), Gaps = 90/715 (12%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKER 304
            +D   +K+S  E  Q++    E +++   K  Q + +        +   +    +E  ER
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQA--KARQAEAAERSRLRIEEEIRVVRLQLEATER 1493

Query: 305  EYS---------EQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIA-AE 354
            +               +  EA  +Q       L  Q +  S + RQ  + L  R+ A AE
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553

Query: 355  GLLCDSQELQALDAL----ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGE 410
                  + LQAL+ L    E    R   A+V    ++QV  ET  R A      EL +  
Sbjct: 1554 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA----ELQSKR 1609

Query: 411  GKLSGR--QKEELLTQQHKAFWQ---EAERFSREFVQ--RGKDLVTASLAH-QVEGTAKL 462
               + +  Q E  L ++H A  Q   EAER +++  +  R ++     L   Q++    L
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669

Query: 463  TL---AQEEEQRSFLAEAQPTADPEKFLEAFHEV-----LERQRLMQCDLEEEENVRATE 514
             L   A+E  Q+  LA+A+     E   EA  E       E Q + Q +L E+E  +  +
Sbjct: 1670 RLRLQAEEVAQQKSLAQAEAEKQKE---EAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726

Query: 515  AVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNR 574
                  Q+   +  +  +     L  +T  G       E +  R + +  AA Q  +   
Sbjct: 1727 LAEGTAQQRLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781

Query: 575  FRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVL---GRLGGLTEEST 631
                + +   E+L   +    EE   +S       E   G  R +     RL  L EE+ 
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841

Query: 632  RC-VLQGHDLLLRSA------LRRLALRGNA--LATLTQMRLSGKKHLLQELR------- 675
            R   L   D   + A        +LA  G A  L T  ++ L  K+   + LR       
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901

Query: 676  -EQRALEQGSSQC---LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLA--EA 729
             ++R LE+ ++Q    ++E   QL +A ++  LE    L E+  + R Q+++ +LA   +
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSE-LERQKGLVEDTLRQRRQVEEEILALKAS 1960

Query: 730  QEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL 789
             E     +  +E  +G+       NA    R+K++ +     +EAA +          R 
Sbjct: 1961 FEKAAAGKAELELELGRI----RSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRR 2011

Query: 790  VQAYYQQIGRIMEDHEERK----LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
                  Q     E+   R+    L+ ++ L+ +  E  +LR++ E         +A    
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE-------QESARQLQ 2064

Query: 846  ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
               +A  +R+ +++K         +Q      QQ+  V+D L  + E   + AE+
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 107/508 (21%), Positives = 188/508 (37%), Gaps = 71/508 (13%)

Query: 245  LDLLPKKKSDDELYQKILSKQEKD------LEELEKGLQVKLSNTEMSGAGDS----EYI 294
            ++ L K K+  E   + L  ++KD       EE EK  QV      +S A         +
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323

Query: 295  TLADVEKKEREYSEQLIDNMEAFWK--QMANIQHFLVDQFKCSSSKARQLMMTLTERMIA 352
               D+ ++     + L + M+A  +  ++      L  Q + +  +AR+L     ++   
Sbjct: 2324 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ---EDKEQM 2380

Query: 353  AEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGK 412
            A+ L  ++Q  Q     ER   +  M+   E LKL+V E +R +  A            +
Sbjct: 2381 AQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439

Query: 413  LSGR-QKEELLTQQHKAFWQ---------------------EAERFSREFVQRGKDLVTA 450
            +  +  + EL TQ+     Q                     E ER   +  Q  K L   
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499

Query: 451  SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLE---AFHEVLERQRLMQCDLEEE 507
            S   Q     +L    +  Q+SFL+E       E+F+E   A  E L +  + +     E
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559

Query: 508  ENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAW 567
            E  R  + +    Q L  S  +  ++  +A              EE   L Q+ ++    
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEA------EEGVRRKQEELQQLEQQRRQQEE- 2612

Query: 568  QLGKSNRFRRQQWKLFQE----LLEQDQQVWMEECALSSVL------------QTHLRED 611
             L + N+  R+Q +L +E     L   ++V   + A +  L            +      
Sbjct: 2613 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2672

Query: 612  HEGTIRGV----LGRLGGLTEESTRCVLQGH---DLLLRSALRRLALRGNALATLTQMRL 664
             +G  R V    L   G L+ E  + + QGH   D L R    R  L+G +      ++ 
Sbjct: 2673 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKA 2732

Query: 665  SGKKHLLQELREQRALEQGSSQCLDEHQ 692
            + +K  +    +++ L  G++  L E Q
Sbjct: 2733 TNEKLSVYAALQRQLLSPGTALILLEAQ 2760


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 150/724 (20%), Positives = 290/724 (40%), Gaps = 114/724 (15%)

Query: 244  LLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYIT-----LAD 298
            L + L    S+ E YQ +++  E+ L + ++  +    N E+     +E+ T     L +
Sbjct: 951  LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010

Query: 299  VEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLC 358
            VEK+++E  +     +E+  +Q++ ++  L           ++    L+    A     C
Sbjct: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD--C 1068

Query: 359  DSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQK 418
              Q   A++A +    R  M    +   LQ  +E   ++A++   LE           QK
Sbjct: 1069 QEQAKIAVEA-QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE--------ETTQK 1119

Query: 419  EELLTQQHKAFWQEAERFSREFV---------------------QRGKDLVTASLAHQVE 457
             E    + KA W+E ER  ++ V                     ++  D V AS+   V+
Sbjct: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179

Query: 458  GTAKLTLAQEEEQRSFLAEAQPTADPEKFL-EAFHEVLE------RQR--LMQCDLEE-- 506
            G   ++L++E + +  + E       EK + E   EV +      RQR  L++ +L+E  
Sbjct: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQ 1239

Query: 507  ------EENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQE 560
                   E V+ T   +A  +EL   T +T    ++            +  EE + L Q+
Sbjct: 1240 DSLNAEREKVQVTAKTMAQHEELMKKT-ETMNVVMET---------NKMLREEKERLEQD 1289

Query: 561  VQENAA---------WQLGKSNRFRRQQWKLFQ---ELLEQDQQVWMEECALSSVLQTHL 608
            +Q+  A           L ++N    ++  + Q   +LLE+D + W    A +  L +  
Sbjct: 1290 LQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWK---ARNQHLVSQQ 1346

Query: 609  REDHEGTIRGVLG-------RLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQ 661
            ++      R +L        R+  LTEE  R             L+    R NA  T  Q
Sbjct: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGR-------------LKAEIARSNASLTNNQ 1393

Query: 662  MRLSGKKHLLQELR-EQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ 720
              +   K  L ++R E+  +++     + + Q ++    + + +    R + + ++ + Q
Sbjct: 1394 NLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKI--GRRYKTQYEELKAQ 1451

Query: 721  LQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDR--DDFKRTLMEAAVES 778
              + +   AQ  G   +QH+     Q L      A TKS++ +   ++ ++TL E   E+
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511

Query: 779  VYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGS 838
              +    V         ++ R+ +D ++R  Q  + L+ +  E  +  +K  ++  S  +
Sbjct: 1512 RNLQEQTVQ-----LQSELSRLRQDLQDRTTQE-EQLRQQITEKEEKTRKAIVAAKSKIA 1565

Query: 839  RTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHA-QQQQAGVMDLLEAQL-ETQLQ 896
              AG   + ++      L Q+   L Q      +R+ A + Q  G +  LE +L E Q +
Sbjct: 1566 HLAGVKDQLTK--ENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQER 1623

Query: 897  EAEQ 900
              EQ
Sbjct: 1624 HLEQ 1627


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 159/703 (22%), Positives = 266/703 (37%), Gaps = 118/703 (16%)

Query: 300  EKKEREYSE------QLIDNMEAFWKQMANIQHFL---VDQFKCSSSKARQLMMTLTERM 350
            +K E+E SE       L  N+E   +  A+ +       DQ   +  K  +L   L +  
Sbjct: 1264 QKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADAS 1323

Query: 351  IAAEGLLCDSQELQAL----DAL--ERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGL 404
                 L  +S EL  L    + L  + + G+A  A+ +E L+ Q++EE++ + +A++H +
Sbjct: 1324 TQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAK-SALAHAV 1382

Query: 405  ELLAGEGKLSGRQKEE----------LLTQQHKAFWQEAERFSREFVQRGKDLVTAS--- 451
            + L  +  L   Q EE          LL++ +    Q   ++  + +QR ++L  A    
Sbjct: 1383 QALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKL 1442

Query: 452  ---LAHQVEGT------------AKLTLAQEEEQRSFLAEAQPTA-----DPEKFLE-AF 490
               L    EG             AKL L  E E  +   E   +A       ++ LE A 
Sbjct: 1443 ALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERAL 1502

Query: 491  HEVLERQRLMQCDLE-------------------EEENVRATEAVVALCQELYFSTVD-T 530
             E   ++  MQ +LE                    EE + A E +    + L     D T
Sbjct: 1503 EERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLT 1562

Query: 531  FQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQD 590
             Q  +    +Q L         E   ++  ++E       +  +  R Q +L Q   E D
Sbjct: 1563 DQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVD 1622

Query: 591  QQVWM--EECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCV---------LQGHD 639
            +++    EECA       +LR +H+  +  +   L   T      +         L   +
Sbjct: 1623 RKLAEKDEECA-------NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE 1675

Query: 640  LLLRSALRRLALRGNALATLTQMRLSGKK-------HLLQELREQ-RALEQGSSQCLDEH 691
            L L  A R+ A    A   L Q +L  ++        L  EL EQ +ALE+ +S    E 
Sbjct: 1676 LQLGHATRQ-ATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAE- 1733

Query: 692  QWQLLRALEARVLEEASRLEEEAQQTRLQLQQRL-LAEAQEVGQLLQQHMECAIGQALLV 750
                L  L A  LE+  R    A+Q  L+  +RL L  +Q  G LL Q  +     A L 
Sbjct: 1734 ----LEELRA-ALEQGERSRRLAEQELLEATERLNLLHSQNTG-LLNQKKKLEADLAQLS 1787

Query: 751  HARNAATKSRAKDRDDFKRTLMEAAVESVYV-----TSAGVSRLVQAYYQQIGRIMEDHE 805
                 A + R +  +  K+ + +AA+ +  +     TSA + R+ +   Q +  +    E
Sbjct: 1788 GEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLE 1847

Query: 806  ERKLQHLKTLQGERMENYKLRKK-QELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLA 864
            E +      L+G + +  KL  K +EL       +            H+R + +    LA
Sbjct: 1848 EAE---QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKE----LA 1900

Query: 865  QFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELA 907
                  +  L   Q     +       + Q +EAEQ   + LA
Sbjct: 1901 YQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLA 1943



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 135/630 (21%), Positives = 243/630 (38%), Gaps = 93/630 (14%)

Query: 247  LLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSN-----TEMSGAGDSEYITLADVEK 301
            LL K K   E   K LS++ +D EE+   L  +        TE+    D   +TLA  EK
Sbjct: 956  LLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEK 1015

Query: 302  KEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQ 361
             E++ +E  + N+    ++MA +     D+     +K ++ +    ++ +    L  +  
Sbjct: 1016 -EKQATENKVKNLT---EEMAAL-----DESVARLTKEKKALQEAHQQALG--DLQAEED 1064

Query: 362  ELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEEL 421
             + AL     T  +  + + +E L+  +++E + R+       +    + KL G  K   
Sbjct: 1065 RVSAL-----TKAKLRLEQQVEDLECSLEQEKKLRM-------DTERAKRKLEGDLK--- 1109

Query: 422  LTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTA 481
            LTQ+  A   + ++   E +++ KD   + L+ +VE    L    +++ +   A A+   
Sbjct: 1110 LTQESVADAAQDKQQLEEKLKK-KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELE 1168

Query: 482  DPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQ 541
            +  +   A    +E+QR       EE + R  EA  A   +                   
Sbjct: 1169 EELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQ------------------- 1209

Query: 542  TLPGMTGLPPEECDY--LRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECA 599
                  G    E +   LR+E++E A          RR+Q +   EL EQ         +
Sbjct: 1210 ----REGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVD-------S 1258

Query: 600  LSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGH-------DLLLRSALRRLALR 652
            L  V Q   +E  E  +R  +  L    E  TR             D L  + ++   L+
Sbjct: 1259 LQRVRQKLEKEKSE--LRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQ 1316

Query: 653  GNALATLTQM-RLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLE 711
                   TQ  RL  +   L  L E++       +CL   Q    +AL A+ LEE  R  
Sbjct: 1317 RQLADASTQRGRLQTESGELSRLLEEK-------ECLIS-QLSRGKALAAQSLEELRRQL 1368

Query: 712  EEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTL 771
            EE  + +  L   + A   +   L +QH E A  QA L    + A    A+ R  ++   
Sbjct: 1369 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADA 1428

Query: 772  MEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQEL 831
            ++   E           L +A  +   R+ E  E  +  + K    E+ +     + +++
Sbjct: 1429 IQRTEE-----------LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 1477

Query: 832  SNPSSGSRTAGGAHETSQAVHQRMLSQQKR 861
            +     + +A  A +  Q   +R L +++R
Sbjct: 1478 TLELERATSAAAALDKKQRHLERALEERRR 1507


>gi|81295809 pericentrin [Homo sapiens]
          Length = 3336

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 73/305 (23%), Positives = 131/305 (42%), Gaps = 39/305 (12%)

Query: 638 HDLLLRSALRRLALRGNALATLTQMRLSGKKHL-LQELRE----QRALEQGSSQCLDEHQ 692
           H L L +    L+    A   LTQ  L  +K   L ELRE    +RA E    Q   +H+
Sbjct: 243 HGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHE 302

Query: 693 WQLLRALEARVLEE-ASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVH 751
            +LLR   AR  EE   R  +EA + + +LQ  +   AQ V + L++  E      L   
Sbjct: 303 LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIV-KTLKEDWESEKDLCLENL 361

Query: 752 ARNAATKSRAKDRD---DFKRTLME--AAVESVYVT---------------SAGVSRLVQ 791
            +  + K +++  D    F++ L E  A +E ++                  A + +L +
Sbjct: 362 RKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRE 421

Query: 792 AYYQQIGRIMED-------HEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGA 844
               + GR +ED        E+ K   L+ LQ    E+ K + ++E+    S   +A  +
Sbjct: 422 DLQSEHGRCLEDLEFKFKESEKEKQLELENLQAS-YEDLKAQSQEEIRRLWSQLDSARTS 480

Query: 845 HETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFIS 904
            +    +H+++L++  R        +Q++   + Q    ++ L    E +L++AE+ +  
Sbjct: 481 RQELSELHEQLLARTSR----VEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQE 536

Query: 905 ELAAL 909
           +L  L
Sbjct: 537 DLTLL 541



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 80/344 (23%), Positives = 154/344 (44%), Gaps = 46/344 (13%)

Query: 586  LLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLL--LR 643
            LLE+ +++  E+  L      HLR     ++   L  +  L  +     LQ  + L  LR
Sbjct: 2487 LLERLEKIIREQGDLQEKSLEHLRLPDRSSL---LSEIQALRAQLRMTHLQNQEKLQHLR 2543

Query: 644  SALRRLALRGNAL-------ATLTQMRLSGKKHLLQELREQRALEQ---GSSQCLDEHQW 693
            +AL     RG+           L   ++  +K +  +L++  + EQ    S Q L   + 
Sbjct: 2544 TALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQ 2603

Query: 694  QLLRALEARVLEEASRLEE------EAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQA 747
             ++R L++ + E   + E+      E QQ  LQL+  L ++  E+   LQ+ +E   G+ 
Sbjct: 2604 TVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQE-LESEQGKG 2662

Query: 748  LLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEER 807
              + ++    + R   R+      +E    S+    A  SRL  A   +  +  +D+ ++
Sbjct: 2663 RALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHE--QTAKDNLQK 2720

Query: 808  KLQHLKTLQGERMENYKLRKKQELSN-----PSSGSRTAGGAHETSQAV-HQRMLSQQ-K 860
            +L+    ++  R E    +++ +LS       +  SRT     E S+A+ H+R+L++Q  
Sbjct: 2721 ELR----IEHSRCEALLAQERSQLSELQKDLAAEKSRTL----ELSEALRHERLLTEQLS 2772

Query: 861  RFLAQFPVHQQMRLH------AQQQQAGVMDLLEAQLETQLQEA 898
            +   +  VHQ  + H       +++++ V+D L+A LE   Q+A
Sbjct: 2773 QRTQEACVHQDTQAHHALLQKLKEEKSRVVD-LQAMLEKVQQQA 2815



 Score = 37.0 bits (84), Expect = 0.092
 Identities = 167/808 (20%), Positives = 308/808 (38%), Gaps = 162/808 (20%)

Query: 217  HLKDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGL 276
            H   L  L T L++E     I++ K+   +L  K + +  L   +   +   +E+ +K L
Sbjct: 677  HKVQLSLLQTELKEE-----IELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKEL 731

Query: 277  QVKLSNTEMSGAGDSEYITLADVEKKE--REYSEQLIDNMEAFWKQMANIQHFLVDQFKC 334
                  TE+         T   V K+E  RE  E+L   +    ++  + +  ++++F+ 
Sbjct: 732  NNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFEL 791

Query: 335  SSSKARQLMMTLTERMIAAEGLLCD--------SQELQALDALERTM-GR-AHMAKVIEF 384
              ++ RQL      +++  E  L +         Q+L + DAL  +  GR    A+  E 
Sbjct: 792  REAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGEL 851

Query: 385  LKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKE--ELLTQQHKAFWQEA-ERFSREFV 441
              L V+E+           L+L+    +    +KE  E  + +  AF QEA E+ +RE  
Sbjct: 852  AALHVKEDC---------ALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQ 902

Query: 442  ------QRGKDLVTASL-AHQVEGTAKLTLAQEEEQRSFLA------EAQPTAD------ 482
                  Q+    VTA L A       +LT + E +Q + LA      + +  AD      
Sbjct: 903  LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALET 962

Query: 483  ---------PEKFLEAFHEVLERQR----LMQCDLEEEENVRATEAVVALCQE---LYFS 526
                        +L  F  + E  R    L++ D EE+   + +     L QE   L   
Sbjct: 963  RHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRK 1022

Query: 527  TVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQ------------EVQENAAWQLGKSNR 574
                 Q   D L  +    + G    E   + Q            E +E    Q  ++  
Sbjct: 1023 HEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQP 1082

Query: 575  FRRQQWK-LFQELLEQDQQVW------------MEEC--ALSSVLQTHLREDHE------ 613
            F +++ + L  +L +++ QV             +EEC   L  + Q   RE+ E      
Sbjct: 1083 FHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLS 1142

Query: 614  -------------GTIRGVLGRLGGLTEESTRCVL-------QGHDLLLRSALRRLAL-R 652
                         G ++  L RL GL  E+ R  +       +   L L  A   LAL  
Sbjct: 1143 MLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALST 1202

Query: 653  GNAL-ATLTQMRLSGKKHLLQELREQRALEQGSS----------QCLDEHQWQLLRALEA 701
              AL  T + + L      L E  E  ++ + SS          + + E +  + R  ++
Sbjct: 1203 APALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQS 1262

Query: 702  RVLE---------EASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHA 752
              L          ++SR  EEA+Q   + ++    + +E  Q++++H E       L+  
Sbjct: 1263 LSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQE-------LLEC 1315

Query: 753  RNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHL 812
                + ++A+   +  +T  +  +E   V +A +  ++           ED E R +  L
Sbjct: 1316 LKEESAAKAELALELHKT--QGTLEGFKVETADLKEVLAG--------KEDSEHRLVLEL 1365

Query: 813  KTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQM 872
            ++L+  R      +++  L    +   + G A  T     +  L ++   L +     + 
Sbjct: 1366 ESLR--RQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTK--EQSET 1421

Query: 873  RLHAQQQQAGV---MDLLEAQLETQLQE 897
            R  A++ ++ +   M +LE++LE QL +
Sbjct: 1422 RKQAEKDRSALLSQMKILESELEEQLSQ 1449



 Score = 34.3 bits (77), Expect = 0.60
 Identities = 78/323 (24%), Positives = 124/323 (38%), Gaps = 61/323 (18%)

Query: 581  KLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLT--EESTRCVLQGH 638
            +  Q  LE++Q   ++  + S+     LR   E T R    RL      E++ +  LQ  
Sbjct: 2663 RALQSQLEEEQLRHLQRESQSAKALEELRASLE-TQRAQSSRLCVALKHEQTAKDNLQKE 2721

Query: 639  DLLLRSALRRLALRGNALATLTQMRLSGKK----HLLQELREQRALEQGSSQCLDE---H 691
              +  S    L  +  +  +  Q  L+ +K     L + LR +R L +  SQ   E   H
Sbjct: 2722 LRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVH 2781

Query: 692  Q-WQLLRALEARVLEEASRLE------EEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAI 744
            Q  Q   AL  ++ EE SR+       E+ QQ  L  QQ+L AEAQ+  + L++  E   
Sbjct: 2782 QDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKE--- 2838

Query: 745  GQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDH 804
                                                  SA +   V+A + Q  R +   
Sbjct: 2839 -------------------------------------VSATLKSTVEALHTQ-KRELRCS 2860

Query: 805  EERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLA 864
             ER+ +    LQ E  +++   K+QE     +  R+A      + A   R   + K  L 
Sbjct: 2861 LEREREKPAWLQAELEQSHPRLKEQE--GRKAARRSAEARQSPAAAEQWRKWQRDKEKLR 2918

Query: 865  QFPVHQQMRLH-AQQQQAGVMDL 886
            +  + +Q  LH  +Q Q  V DL
Sbjct: 2919 ELELQRQRDLHKIKQLQQTVRDL 2941



 Score = 30.4 bits (67), Expect = 8.6
 Identities = 69/299 (23%), Positives = 115/299 (38%), Gaps = 35/299 (11%)

Query: 629  ESTRCVLQGHDLLLRSALRRLALRGNALATL--TQMRLSGKKHLLQELREQRALEQGSSQ 686
            E T  V++ H  LL       A +      L  TQ  L G K    +L+E  A ++ S  
Sbjct: 1300 EETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEH 1359

Query: 687  CLDEHQWQLLRALEAR------VLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHM 740
             L      L R L+        + EE +RL    + T    + R  A  +EV  L ++  
Sbjct: 1360 RLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQS 1419

Query: 741  ECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSR---LVQAYYQQI 797
            E           R  A K R+      K  ++E+ +E       G ++    V A  QQ+
Sbjct: 1420 E----------TRKQAEKDRSALLSQMK--ILESELEEQLSQHRGCAKQAEAVTALEQQV 1467

Query: 798  GRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAG-----GAHETSQAV- 851
               ++ H   + Q +     ER E+ +   +QE+       R A      G  ++ QA  
Sbjct: 1468 AS-LDKHLRNQRQFMDEQAAER-EHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPL 1525

Query: 852  -HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAAL 909
              +  L QQK    +  + +   L  Q++ A    L++ +   +L+E   N   ++A L
Sbjct: 1526 DGEVELLQQK---LREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQL 1581


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 188/895 (21%), Positives = 335/895 (37%), Gaps = 193/895 (21%)

Query: 131  ADGSSNPSLHENLKQAVLPHQPVEASP-------SSSLGSLSQGEKDDCSSSSSVHSATS 183
            A  S+  SL +N   A      +  SP       ++SL   S  E D   S SS +S+ S
Sbjct: 265  APDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSSYSSAS 324

Query: 184  DDR---FLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIF 240
                   LS+T +     P ++  + +  D       +KD+L    A  Q++        
Sbjct: 325  TRGTYGILSKT-VGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQ------ 377

Query: 241  KMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVE 300
                 ++  + +S  +     +S +    E  E+ LQV      + G  ++  +  +   
Sbjct: 378  -----EVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQAL 432

Query: 301  KKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCS-SSKARQ------------------ 341
            K++ E   QL           A +   L  Q +CS SS+ RQ                  
Sbjct: 433  KEKAELQAQL-----------AALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLE 481

Query: 342  LMMTLTERMIAAEG--LLCDSQELQ-ALDALERTMGRAHMAKVIEFLKLQVQEETRCRLA 398
              MT  + M+ A+   L   + +LQ A +  +R M +    +     K     + R ++ 
Sbjct: 482  RAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMT 541

Query: 399  AISHGLE------------LLAGEGKLSGRQKEELLTQQHKAFWQEAE-RFSREF--VQR 443
            A+   L+            L A + ++S  Q      QQ  A  QEA  R   E   +Q 
Sbjct: 542  ALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQV 601

Query: 444  GKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEA--------FHEVLE 495
            G+      L H       L+    E Q   + E    A   + +EA        F ++ E
Sbjct: 602  GQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQE 661

Query: 496  RQRLMQCDL---------EEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGM 546
             + +++ DL         E E   R  ++  +L Q+L         + V    LQ    +
Sbjct: 662  AKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQL---------EQVKLTLLQRDQQL 712

Query: 547  TGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQT 606
              L  E  D ++Q                      L QE L+  +Q           LQT
Sbjct: 713  EALQQEHLDLMKQLT--------------------LTQEALQSREQSL-------DALQT 745

Query: 607  HLREDHEGTIRGVLGRLGG--LTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRL 664
            H  E     ++  LG L G   + E T C+LQ   ++L +AL+        L    +   
Sbjct: 746  HYDE-----LQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLE 800

Query: 665  SGKKHL---LQELREQRALEQGSSQCLDEH------QWQLLRA--LEARVLEEASRLEEE 713
             G +     L++LRE+ A++ G  + L +       Q Q ++   L+ +V+ EA R +  
Sbjct: 801  EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDAT 860

Query: 714  AQQTRLQ----LQQRLLAEAQEVGQ-LLQQHMECAIGQALL--VHARNAATK-------- 758
            ++   +      ++RL +E +E+ Q L+Q H E    +A L  +H   A  +        
Sbjct: 861  SKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEG 920

Query: 759  ---SRAKDRDDFKRTLMEAAVES---VYVTSAG--VSRLVQAYYQQIGRIMEDHEERKLQ 810
               S  K+RD+ +  L     +    V VT A   + + ++   Q+  + + + +++  +
Sbjct: 921  HLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRR 980

Query: 811  ---HLKTLQGERMENYKL---------RKKQELSNPSSGS-------RTAGGAHETSQAV 851
                L + Q E    +K          R+ QE       +       R  GG+ ++S A+
Sbjct: 981  LGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLAL 1040

Query: 852  HQRMLS--------QQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEA 898
            H+R+ +           + L +  + + + L +Q+ +     +LE  LE +LQE+
Sbjct: 1041 HERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE--LEDELQES 1093



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 187/952 (19%), Positives = 363/952 (38%), Gaps = 128/952 (13%)

Query: 121  YPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHS 180
            Y +N +  P       PS+ + L+ A   HQ      +  + S     +D   SS S+ S
Sbjct: 343  YMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRS----RRDSICSSVSLES 398

Query: 181  ATSDDRF----LSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMF 236
            + ++ +     + +  +R+    E L+ E+        S  LK+   L   L      + 
Sbjct: 399  SAAETQEEMLQVLKEKMRLEGQLEALSLEA--------SQALKEKAELQAQLAALSTKLQ 450

Query: 237  IQIFKMCLLDLLPKKKSDDELYQKILSKQEK--DLEELEKGLQVKLSNTEMSGAGDSEYI 294
             Q+   C       ++  D L  ++ + ++   DLE     LQ  L     S A  +   
Sbjct: 451  AQV--ECSHS---SQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNN-- 503

Query: 295  TLADVEKKEREYSEQL--IDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMM---TLTER 349
               D++  E +Y   +  +++M+       N  H L  Q     S+ +Q+ +   TLT +
Sbjct: 504  ---DLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSK 560

Query: 350  MIAAEGLLCDSQELQ---------ALDALERTMGR-AHM-------AKVIEFLKL----- 387
            + A++  +   Q ++         A +A  R  G  AH+       A ++E LKL     
Sbjct: 561  LKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSL 620

Query: 388  --QVQE------ETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFS-- 437
              Q+ E      + + R+AA   G+E    + + +  Q +E  T   +   +  E F   
Sbjct: 621  SQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGE 680

Query: 438  REFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQ 497
            RE +QR  D   ASL  Q+E   KLTL Q ++Q   L   Q   D  K L    E L+ +
Sbjct: 681  RERLQRMADSA-ASLEQQLE-QVKLTLLQRDQQLEAL--QQEHLDLMKQLTLTQEALQSR 736

Query: 498  R----LMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLP--- 550
                  +Q   +E +         A  +E     +   +  ++A       G   L    
Sbjct: 737  EQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGA 796

Query: 551  ------PEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVL 604
                   EE     ++++E  A + G+    +++   L +++ +  +Q   ++  + +  
Sbjct: 797  RRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYR 856

Query: 605  QTHLREDH-EGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMR 663
            +    +D     ++    RL    +E  + ++Q H    R+A   L+     +A + Q  
Sbjct: 857  RDATSKDQLISELKATRKRLDSELKELRQELMQVHG-EKRTAEAELSRLHREVAQVRQHM 915

Query: 664  LSGKKHLLQELREQRALEQG-SSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQ 722
               + HL    +E+  +E    S   D+ Q   +      + ++   L++EA++   + +
Sbjct: 916  ADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQK 975

Query: 723  QRL------LAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRD----------- 765
            Q++      L  AQ+  +   +  E A+G  L    + A     A D +           
Sbjct: 976  QKMRRLGSDLTSAQKEMKTKHKAYENAVG-ILSRRLQEALAAKEAADAELGQLRAQGGSS 1034

Query: 766  DFKRTL------MEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGER 819
            D    L      +EA +++V  +   + + +Q       + +E+  E+ L+    LQ  R
Sbjct: 1035 DSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESR 1094

Query: 820  MENYKLRKKQELSNP-------SSGSRTAGGAHETSQAVH----QRMLSQQKRFLAQFPV 868
                K+++ +E +           G  T  G    +   H    +  L++++  L Q  +
Sbjct: 1095 GFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNL 1154

Query: 869  HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ--NFISELAALARVPLAES----KLLPA 922
              Q  L  ++++   M  L   L+  L++ ++  N + E  A A+V    +    K    
Sbjct: 1155 QVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASL 1214

Query: 923  KRGLLEKPLRTKRK--KPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQ 972
            +   ++K L+ K    + L  E  DL +   +      Q    L+  R   Q
Sbjct: 1215 ELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQ 1266


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 175/791 (22%), Positives = 312/791 (39%), Gaps = 120/791 (15%)

Query: 246  DLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGA--GDSEYITLADVEKKE 303
            D L K++   +  +K+  + + +  EL++ +  +    E   A  G  E    A + + E
Sbjct: 1066 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1125

Query: 304  REYSE--QLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQ 361
             E     QL+ ++      +A  Q  L  + + + +KA +    L E + A  G L D+ 
Sbjct: 1126 DEGGARAQLLKSLREAQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDT- 1183

Query: 362  ELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEEL 421
             L + +A +    R+   + +  LK  ++EETR   AA+    EL    G+  G   E+L
Sbjct: 1184 -LDSTNAQQEL--RSKREQEVTELKKTLEEETRIHEAAVQ---ELRQRHGQALGELAEQL 1237

Query: 422  LTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQ--- 478
                     ++A R    + +    L       + E ++  T  QE EQR    E Q   
Sbjct: 1238 ---------EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1288

Query: 479  ---PTADPEKFLEAFHEVLERQRLMQCDLEEEENV--RATEAVVALCQELYFSTVDTFQK 533
                  D E+   A  E  E+ +  Q +LE        A    + L +EL  ST      
Sbjct: 1289 VQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHD 1344

Query: 534  FVDALFLQT-----LPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLE 588
              + L  +T     L         E   LR++++E AA +       +  Q +L +    
Sbjct: 1345 AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1404

Query: 589  QDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRR 648
            Q++    E  AL +  +   R   E     +  RL   TE   R         L    RR
Sbjct: 1405 QEE----EAGALEAGEEARRRAAREA--EALTQRLAEKTETVDR---------LERGRRR 1449

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
            L      L   T M L  ++ L+  L ++   ++   Q L E +  +LRA+E R   EA 
Sbjct: 1450 LQ---QELDDAT-MDLEQQRQLVSTLEKK---QRKFDQLLAEEKAAVLRAVEERERAEAE 1502

Query: 709  RLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMEC--AIGQALL---------VHARNAAT 757
              E EA+   L    R L E QE  + L++      A  +ALL         VH    A 
Sbjct: 1503 GREREARALSLT---RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1559

Query: 758  KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL-----VQAYYQQIGRIMEDH----EERK 808
            +   +  +D +  + E   E   +T+A  ++L     VQA   Q  R ++      EER+
Sbjct: 1560 RVAEQAANDLRAQVTELEDE---LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1616

Query: 809  LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPV 868
             Q  K L+   +E  + RK++ L                + A  +++  + +   AQ   
Sbjct: 1617 RQLAKQLRDAEVERDEERKQRTL----------------AVAARKKLEGELEELKAQMAS 1660

Query: 869  HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLL- 927
              Q +  A +Q    +  ++AQ++   +E E+   S     ++   +E +L   +  +L 
Sbjct: 1661 AGQGKEEAVKQ----LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1716

Query: 928  ---EKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSK------RLSQQESEAGD 978
               E     + ++   Q+R ++     +++A+G+ +  ++  +      RL Q E E  +
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMA----DEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1772

Query: 979  SGNSKKMLKRR 989
              ++ ++L  R
Sbjct: 1773 EQSNSELLNDR 1783



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 147/671 (21%), Positives = 255/671 (38%), Gaps = 72/671 (10%)

Query: 354  EGLLCDSQELQALDALERTMGRA-------------HMAKVIEFLKLQVQ-----EETRC 395
            E L   +QELQ +  L++   R                A++ E L+ + +     EETR 
Sbjct: 877  EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 936

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
            RLAA    LEL+  E +    ++EE   Q       E +R  +   +    L     A Q
Sbjct: 937  RLAARKQELELVVSELEARVGEEEECSRQMQ----TEKKRLQQHIQELEAHLEAEEGARQ 992

Query: 456  VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCD---LEEEENVRA 512
                 K+T   E + + F  +     D    L    ++LE  RL +      EEEE V++
Sbjct: 993  KLQLEKVT--TEAKMKKFEEDLLLLEDQNSKLSKERKLLE-DRLAEFSSQAAEEEEKVKS 1049

Query: 513  TEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKS 572
               +    +       D  +K  +    Q L  +        D    E+QE    Q  ++
Sbjct: 1050 LNKLRLKYEATIADMEDRLRK--EEKGRQELEKL----KRRLDGESSELQEQMVEQQQRA 1103

Query: 573  NRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTR 632
               R Q  +  +EL     +   E  A + +L++ LRE  +  +      L       T+
Sbjct: 1104 EELRAQLGRKEEELQAALARAEDEGGARAQLLKS-LRE-AQAALAEAQEDLESERVARTK 1161

Query: 633  CVLQGHDL-----LLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQ--------RA 679
               Q  DL      LR  L       NA   L   R      L + L E+        + 
Sbjct: 1162 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1221

Query: 680  LEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQH 739
            L Q   Q L E   QL +A   +   E +RL  EA+ + L+ +   L  A++ G+  ++ 
Sbjct: 1222 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1281

Query: 740  MECAI-------GQALLVHARNAATKSRAK-DRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
            +E  +       G      A  A    RA+ + ++    L EA  +++ ++    S   Q
Sbjct: 1282 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341

Query: 792  AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAV 851
             +  Q   ++++    KL     ++    E   LR  ++L   ++    AG   +T+QA 
Sbjct: 1342 LHDAQ--ELLQEETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQ 1397

Query: 852  HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLET--QLQEAEQNFISELAAL 909
                  +Q+         ++ R  A ++   +   L  + ET  +L+   +    EL   
Sbjct: 1398 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD- 1456

Query: 910  ARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDL--GVPNNE--DLASGDQTSGSLS 965
            A + L + + L +    LEK  R K  + L +E+  +   V   E  +    ++ + +LS
Sbjct: 1457 ATMDLEQQRQLVS---TLEKKQR-KFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1512

Query: 966  SKRLSQQESEA 976
              R  ++E EA
Sbjct: 1513 LTRALEEEQEA 1523


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 175/791 (22%), Positives = 312/791 (39%), Gaps = 120/791 (15%)

Query: 246  DLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGA--GDSEYITLADVEKKE 303
            D L K++   +  +K+  + + +  EL++ +  +    E   A  G  E    A + + E
Sbjct: 1058 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1117

Query: 304  REYSE--QLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQ 361
             E     QL+ ++      +A  Q  L  + + + +KA +    L E + A  G L D+ 
Sbjct: 1118 DEGGARAQLLKSLREAQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDT- 1175

Query: 362  ELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEEL 421
             L + +A +    R+   + +  LK  ++EETR   AA+    EL    G+  G   E+L
Sbjct: 1176 -LDSTNAQQEL--RSKREQEVTELKKTLEEETRIHEAAVQ---ELRQRHGQALGELAEQL 1229

Query: 422  LTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQ--- 478
                     ++A R    + +    L       + E ++  T  QE EQR    E Q   
Sbjct: 1230 ---------EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1280

Query: 479  ---PTADPEKFLEAFHEVLERQRLMQCDLEEEENV--RATEAVVALCQELYFSTVDTFQK 533
                  D E+   A  E  E+ +  Q +LE        A    + L +EL  ST      
Sbjct: 1281 VQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHD 1336

Query: 534  FVDALFLQT-----LPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLE 588
              + L  +T     L         E   LR++++E AA +       +  Q +L +    
Sbjct: 1337 AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1396

Query: 589  QDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRR 648
            Q++    E  AL +  +   R   E     +  RL   TE   R         L    RR
Sbjct: 1397 QEE----EAGALEAGEEARRRAAREA--EALTQRLAEKTETVDR---------LERGRRR 1441

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
            L      L   T M L  ++ L+  L ++   ++   Q L E +  +LRA+E R   EA 
Sbjct: 1442 LQ---QELDDAT-MDLEQQRQLVSTLEKK---QRKFDQLLAEEKAAVLRAVEERERAEAE 1494

Query: 709  RLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMEC--AIGQALL---------VHARNAAT 757
              E EA+   L    R L E QE  + L++      A  +ALL         VH    A 
Sbjct: 1495 GREREARALSLT---RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1551

Query: 758  KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL-----VQAYYQQIGRIMEDH----EERK 808
            +   +  +D +  + E   E   +T+A  ++L     VQA   Q  R ++      EER+
Sbjct: 1552 RVAEQAANDLRAQVTELEDE---LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1608

Query: 809  LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPV 868
             Q  K L+   +E  + RK++ L                + A  +++  + +   AQ   
Sbjct: 1609 RQLAKQLRDAEVERDEERKQRTL----------------AVAARKKLEGELEELKAQMAS 1652

Query: 869  HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLL- 927
              Q +  A +Q    +  ++AQ++   +E E+   S     ++   +E +L   +  +L 
Sbjct: 1653 AGQGKEEAVKQ----LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1708

Query: 928  ---EKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSK------RLSQQESEAGD 978
               E     + ++   Q+R ++     +++A+G+ +  ++  +      RL Q E E  +
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMA----DEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1764

Query: 979  SGNSKKMLKRR 989
              ++ ++L  R
Sbjct: 1765 EQSNSELLNDR 1775



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 147/671 (21%), Positives = 255/671 (38%), Gaps = 72/671 (10%)

Query: 354  EGLLCDSQELQALDALERTMGRA-------------HMAKVIEFLKLQVQ-----EETRC 395
            E L   +QELQ +  L++   R                A++ E L+ + +     EETR 
Sbjct: 869  EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 928

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
            RLAA    LEL+  E +    ++EE   Q       E +R  +   +    L     A Q
Sbjct: 929  RLAARKQELELVVSELEARVGEEEECSRQMQ----TEKKRLQQHIQELEAHLEAEEGARQ 984

Query: 456  VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCD---LEEEENVRA 512
                 K+T   E + + F  +     D    L    ++LE  RL +      EEEE V++
Sbjct: 985  KLQLEKVT--TEAKMKKFEEDLLLLEDQNSKLSKERKLLE-DRLAEFSSQAAEEEEKVKS 1041

Query: 513  TEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKS 572
               +    +       D  +K  +    Q L  +        D    E+QE    Q  ++
Sbjct: 1042 LNKLRLKYEATIADMEDRLRK--EEKGRQELEKL----KRRLDGESSELQEQMVEQQQRA 1095

Query: 573  NRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTR 632
               R Q  +  +EL     +   E  A + +L++ LRE  +  +      L       T+
Sbjct: 1096 EELRAQLGRKEEELQAALARAEDEGGARAQLLKS-LRE-AQAALAEAQEDLESERVARTK 1153

Query: 633  CVLQGHDL-----LLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQ--------RA 679
               Q  DL      LR  L       NA   L   R      L + L E+        + 
Sbjct: 1154 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1213

Query: 680  LEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQH 739
            L Q   Q L E   QL +A   +   E +RL  EA+ + L+ +   L  A++ G+  ++ 
Sbjct: 1214 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1273

Query: 740  MECAI-------GQALLVHARNAATKSRAK-DRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
            +E  +       G      A  A    RA+ + ++    L EA  +++ ++    S   Q
Sbjct: 1274 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333

Query: 792  AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAV 851
             +  Q   ++++    KL     ++    E   LR  ++L   ++    AG   +T+QA 
Sbjct: 1334 LHDAQ--ELLQEETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQ 1389

Query: 852  HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLET--QLQEAEQNFISELAAL 909
                  +Q+         ++ R  A ++   +   L  + ET  +L+   +    EL   
Sbjct: 1390 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD- 1448

Query: 910  ARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDL--GVPNNE--DLASGDQTSGSLS 965
            A + L + + L +    LEK  R K  + L +E+  +   V   E  +    ++ + +LS
Sbjct: 1449 ATMDLEQQRQLVS---TLEKKQR-KFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1504

Query: 966  SKRLSQQESEA 976
              R  ++E EA
Sbjct: 1505 LTRALEEEQEA 1515


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 175/791 (22%), Positives = 312/791 (39%), Gaps = 120/791 (15%)

Query: 246  DLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGA--GDSEYITLADVEKKE 303
            D L K++   +  +K+  + + +  EL++ +  +    E   A  G  E    A + + E
Sbjct: 1099 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE 1158

Query: 304  REYSE--QLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQ 361
             E     QL+ ++      +A  Q  L  + + + +KA +    L E + A  G L D+ 
Sbjct: 1159 DEGGARAQLLKSLREAQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDT- 1216

Query: 362  ELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEEL 421
             L + +A +    R+   + +  LK  ++EETR   AA+    EL    G+  G   E+L
Sbjct: 1217 -LDSTNAQQEL--RSKREQEVTELKKTLEEETRIHEAAVQ---ELRQRHGQALGELAEQL 1270

Query: 422  LTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQ--- 478
                     ++A R    + +    L       + E ++  T  QE EQR    E Q   
Sbjct: 1271 ---------EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1321

Query: 479  ---PTADPEKFLEAFHEVLERQRLMQCDLEEEENV--RATEAVVALCQELYFSTVDTFQK 533
                  D E+   A  E  E+ +  Q +LE        A    + L +EL  ST      
Sbjct: 1322 VQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHD 1377

Query: 534  FVDALFLQT-----LPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLE 588
              + L  +T     L         E   LR++++E AA +       +  Q +L +    
Sbjct: 1378 AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1437

Query: 589  QDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRR 648
            Q++    E  AL +  +   R   E     +  RL   TE   R         L    RR
Sbjct: 1438 QEE----EAGALEAGEEARRRAAREA--EALTQRLAEKTETVDR---------LERGRRR 1482

Query: 649  LALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEAS 708
            L      L   T M L  ++ L+  L ++   ++   Q L E +  +LRA+E R   EA 
Sbjct: 1483 LQ---QELDDAT-MDLEQQRQLVSTLEKK---QRKFDQLLAEEKAAVLRAVEERERAEAE 1535

Query: 709  RLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMEC--AIGQALL---------VHARNAAT 757
              E EA+   L    R L E QE  + L++      A  +ALL         VH    A 
Sbjct: 1536 GREREARALSLT---RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1592

Query: 758  KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL-----VQAYYQQIGRIMEDH----EERK 808
            +   +  +D +  + E   E   +T+A  ++L     VQA   Q  R ++      EER+
Sbjct: 1593 RVAEQAANDLRAQVTELEDE---LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1649

Query: 809  LQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPV 868
             Q  K L+   +E  + RK++ L                + A  +++  + +   AQ   
Sbjct: 1650 RQLAKQLRDAEVERDEERKQRTL----------------AVAARKKLEGELEELKAQMAS 1693

Query: 869  HQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLL- 927
              Q +  A +Q    +  ++AQ++   +E E+   S     ++   +E +L   +  +L 
Sbjct: 1694 AGQGKEEAVKQ----LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1749

Query: 928  ---EKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSK------RLSQQESEAGD 978
               E     + ++   Q+R ++     +++A+G+ +  ++  +      RL Q E E  +
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMA----DEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1805

Query: 979  SGNSKKMLKRR 989
              ++ ++L  R
Sbjct: 1806 EQSNSELLNDR 1816



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 147/671 (21%), Positives = 255/671 (38%), Gaps = 72/671 (10%)

Query: 354  EGLLCDSQELQALDALERTMGRA-------------HMAKVIEFLKLQVQ-----EETRC 395
            E L   +QELQ +  L++   R                A++ E L+ + +     EETR 
Sbjct: 910  EVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 969

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
            RLAA    LEL+  E +    ++EE   Q       E +R  +   +    L     A Q
Sbjct: 970  RLAARKQELELVVSELEARVGEEEECSRQMQ----TEKKRLQQHIQELEAHLEAEEGARQ 1025

Query: 456  VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCD---LEEEENVRA 512
                 K+T   E + + F  +     D    L    ++LE  RL +      EEEE V++
Sbjct: 1026 KLQLEKVT--TEAKMKKFEEDLLLLEDQNSKLSKERKLLE-DRLAEFSSQAAEEEEKVKS 1082

Query: 513  TEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKS 572
               +    +       D  +K  +    Q L  +        D    E+QE    Q  ++
Sbjct: 1083 LNKLRLKYEATIADMEDRLRK--EEKGRQELEKL----KRRLDGESSELQEQMVEQQQRA 1136

Query: 573  NRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTR 632
               R Q  +  +EL     +   E  A + +L++ LRE  +  +      L       T+
Sbjct: 1137 EELRAQLGRKEEELQAALARAEDEGGARAQLLKS-LRE-AQAALAEAQEDLESERVARTK 1194

Query: 633  CVLQGHDL-----LLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQ--------RA 679
               Q  DL      LR  L       NA   L   R      L + L E+        + 
Sbjct: 1195 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1254

Query: 680  LEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQH 739
            L Q   Q L E   QL +A   +   E +RL  EA+ + L+ +   L  A++ G+  ++ 
Sbjct: 1255 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1314

Query: 740  MECAI-------GQALLVHARNAATKSRAK-DRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
            +E  +       G      A  A    RA+ + ++    L EA  +++ ++    S   Q
Sbjct: 1315 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1374

Query: 792  AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAV 851
             +  Q   ++++    KL     ++    E   LR  ++L   ++    AG   +T+QA 
Sbjct: 1375 LHDAQ--ELLQEETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQ 1430

Query: 852  HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLET--QLQEAEQNFISELAAL 909
                  +Q+         ++ R  A ++   +   L  + ET  +L+   +    EL   
Sbjct: 1431 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD- 1489

Query: 910  ARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDL--GVPNNE--DLASGDQTSGSLS 965
            A + L + + L +    LEK  R K  + L +E+  +   V   E  +    ++ + +LS
Sbjct: 1490 ATMDLEQQRQLVS---TLEKKQR-KFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1545

Query: 966  SKRLSQQESEA 976
              R  ++E EA
Sbjct: 1546 LTRALEEEQEA 1556


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 136/706 (19%), Positives = 268/706 (37%), Gaps = 53/706 (7%)

Query: 222  LHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLS 281
            + L  AL +++  +     +  L   L +K+  D+   K+   +   ++ELE+  Q    
Sbjct: 1032 MRLQNALNEQR--VEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089

Query: 282  NTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQ 341
              E     + E+ + +  + +    +E     +EA   +++ ++     Q + + S  R 
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149

Query: 342  L---MMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCR-- 396
            L     +  ER  A E L    +E +A +        A   + +   + +VQ+ ++    
Sbjct: 1150 LEAERASRAERDSALETLQGQLEE-KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208

Query: 397  -LAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
              A ++ G +    +  L    +EE+     +   +E E  S+E     K LV A     
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE--SKEL----KRLVMAESEKS 1262

Query: 456  VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEA 515
             +   +L L Q E   +    A+ ++   + +++  E  E+QR+   +L +E   +A E 
Sbjct: 1263 QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQA-ER 1321

Query: 516  VVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRF 575
               L QEL       FQK      LQ     T     E    +   Q+  A Q     R 
Sbjct: 1322 AEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381

Query: 576  RRQQWKLFQELLEQDQQVWMEECALSSVLQTHLR-EDHEGTIRGVLGRLGGLTEESTRCV 634
            R +  +  Q       ++   +  L  ++    +  + E T + +        E+ +  +
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSM-L 1440

Query: 635  LQGHDLLLRSALRRLALRGNALATLTQMRLS-GKKHLLQELREQRALEQGSSQCLDEHQW 693
             + H LL     R L  R N      ++ L   ++  +QEL   RA  +     +     
Sbjct: 1441 KKAHGLLAEEN-RGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQ 1499

Query: 694  QLLRALEA----------RVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECA 743
               R LE           +VLEE  R +EE Q+   Q++Q  + + ++  Q+ +   + A
Sbjct: 1500 STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559

Query: 744  -IGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIME 802
               QA  V  +              +   ++A +  +    +   +  + Y  Q+ +   
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619

Query: 803  DHEERKLQH------LKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRML 856
             ++ +K Q+      L++L+  + EN +LR + E              HE  QA  +   
Sbjct: 1620 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERL-----------GHELQQAGLKTKE 1668

Query: 857  SQQ--KRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
            ++Q  +   AQ    +    HA QQ   + DL + Q+ T   ++ +
Sbjct: 1669 AEQTCRHLTAQVRSLEAQVAHADQQ---LRDLGKFQVATDALKSRE 1711



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 141/740 (19%), Positives = 275/740 (37%), Gaps = 72/740 (9%)

Query: 262  LSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQM 321
            LS   K  E+  K +  K   T    A   +  T A+  +      +  +  +EA  K+ 
Sbjct: 556  LSSSLKQKEQQLKEVAEKQEATRQDHA--QQLATAAEEREASLRERDAALKQLEALEKEK 613

Query: 322  ANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKV 381
            A     L  Q + ++        ++T+       L    +ELQA     R       A+V
Sbjct: 614  AAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV 673

Query: 382  IEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFV 441
             E L+LQ++ E +             A E +   ++K++L  Q+     +E+ + ++  +
Sbjct: 674  AE-LELQLRSEQQ------------KATEKERVAQEKDQL--QEQLQALKESLKVTKGSL 718

Query: 442  QRGKDLVTASLAHQVEGTAKL---TLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQR 498
            +  K     +L  Q    ++L   T +  E+ +    E +      K LEA  + L    
Sbjct: 719  EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAH 778

Query: 499  LMQCDL---EEEENVRATEAVVALCQELYFSTVDTFQKFVD---------ALFLQTLPGM 546
              + ++   E  E + A     + C++L        +++ D         A+F + L  +
Sbjct: 779  QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTL 838

Query: 547  TGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQT 606
                 EEC+  RQE+QE      G  +    Q  +   EL E    +     AL  V + 
Sbjct: 839  K----EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANL---ARALQQVQEK 891

Query: 607  HLR-EDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLS 665
             +R +     +  +  ++   ++E  R      + L+R A  +       L         
Sbjct: 892  EVRAQKLADDLSTLQEKMAATSKEVARL-----ETLVRKAGEQQETASRELVKEPARAGD 946

Query: 666  GKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRL 725
             +   L+E       +QG   C  +   Q +     ++  E  RL     +++ Q Q+  
Sbjct: 947  RQPEWLEE-------QQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999

Query: 726  LAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAG 785
              + +EV +L Q+      G+A    A   A ++  + R   +  L E  VE   +  A 
Sbjct: 1000 GQQEREVARLTQER-----GRAQADLALEKAARAELEMR--LQNALNEQRVEFATLQEAL 1052

Query: 786  VSRLV--QAYYQQIGRI--MEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTA 841
               L   +   Q++ ++  +E  + ++L+ L+    +  E    ++K+  S   + S  A
Sbjct: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA 1112

Query: 842  GGAHETSQAVHQ-----RMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQ 896
            G    T   +         L QQ +   +     +  L A++      D     L+ QL+
Sbjct: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172

Query: 897  EAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLAS 956
            E  Q      +ALA    +  + L A R  ++   + + +      RG         L S
Sbjct: 1173 EKAQELGHSQSALA----SAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228

Query: 957  GDQTSGSLSSKRLSQQESEA 976
              +   S+ ++++ ++E E+
Sbjct: 1229 SLEEEVSILNRQVLEKEGES 1248



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 71/341 (20%), Positives = 136/341 (39%), Gaps = 39/341 (11%)

Query: 584 QELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLR 643
           QEL    QQ   ++  L+  LQ       E   +G+  ++    E+ +  + Q    L  
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQ-----QQEQASQGLRHQV----EQLSSSLKQKEQQLKE 569

Query: 644 SALRRLALR---GNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALE 700
            A ++ A R      LAT  + R +  +     L++  ALE+  +  L+  Q QL  A E
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629

Query: 701 ARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQ---ALLVHARNAAT 757
           AR   + S  + + ++  L  +   L    E  +  Q   +  + +    L    + A  
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689

Query: 758 KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQG 817
           K R     D  +  ++A  ES+ VT   +    +     +     + ++R +  LK    
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL-----EEQQRCISELKAETR 744

Query: 818 ERMENYKLRKKQELSNPSSGSR-------TAGGAHETSQAVHQRML-----------SQQ 859
             +E +K R+++EL    +G +         G AH+    V +R L           S+ 
Sbjct: 745 SLVEQHK-RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803

Query: 860 KRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
           ++ + +    ++    +QQ++A    + + QL T  +E E+
Sbjct: 804 EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 56/263 (21%), Positives = 108/263 (41%), Gaps = 36/263 (13%)

Query: 700 EARVLEEASRLEEEAQQ-----TRLQLQQRLLAEA-QEVGQLLQQHMECAIGQALLVHAR 753
           EA++L E    EEE QQ     T LQ     L++A +E+ Q  Q H     G  L     
Sbjct: 447 EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH-----GARLTAQVA 501

Query: 754 NAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEE--RKLQH 811
           +  +          + T + A ++      AG+ +  +    Q+ + ++  E+  + L+H
Sbjct: 502 SLTS----------ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRH 551

Query: 812 -----LKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQF 866
                  +L+ +  +  ++ +KQE +      + A  A E   ++ +R  + ++  L   
Sbjct: 552 QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ--LEAL 609

Query: 867 PVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQ------NFISELAALARVPLAESKLL 920
              +  +L   QQQ  V +      +T + +A++        + EL A       E    
Sbjct: 610 EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669

Query: 921 PAKRGLLEKPLRTKRKKPLPQER 943
            A+   LE  LR++++K   +ER
Sbjct: 670 QAQVAELELQLRSEQQKATEKER 692


>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
          Length = 1133

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 137/613 (22%), Positives = 243/613 (39%), Gaps = 70/613 (11%)

Query: 337  SKARQLMMTLT--ERMIAAE-GLLCDSQELQALDALERTMGRAHMAKVIEFLKLQ-VQEE 392
            S AR L+ +    ++++AA+  L C   ELQA + L      A +   +  L+L+  Q E
Sbjct: 549  SLARSLLPSTEYQKQLLAAQVQLQCSPAELQA-ELLHSQARLAELEAQVRKLELERAQHE 607

Query: 393  TRCRLAAISH--GLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTA 450
                     H   LEL+    +   +  E    Q+ +   +E E  S  ++ + ++   A
Sbjct: 608  LLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQA 667

Query: 451  SLAHQVEGTAKLT-LAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEEN 509
                  +   +L  +AQE++Q          A          E L+R +L++ D E +  
Sbjct: 668  RAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLK-DREVDAA 726

Query: 510  VRATEAVVALCQ-----ELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQEN 564
              AT    +L       E + S++      V+A  L T      L   + D   + +QE 
Sbjct: 727  TSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERE-LGIRQRDEQLRALQER 785

Query: 565  AAWQLGKSNRFRRQQWKLF----------QELLEQDQQVWMEECALSSVLQTHLREDHEG 614
               Q       R +Q ++             LLEQ++     E + +  +Q  L E  + 
Sbjct: 786  LGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKV 845

Query: 615  TIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQEL 674
            T + +      L    +  + +   ++L+    R  L         Q +LS ++    E 
Sbjct: 846  TAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKER---AER 902

Query: 675  REQRALE-----QGSSQCLDEHQWQL------LRALEARVLEEASRLEEEAQQTRLQLQQ 723
              +RAL+     +G+   L + Q +L      LRA E ++  E + LE+E Q+ RL+ ++
Sbjct: 903  EAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLE-KE 961

Query: 724  RLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTS 783
            R+ A A  V +L  + +E             + +K  ++  ++ +R L EA      V +
Sbjct: 962  RINATALRV-KLRAEEVE-------------SMSKVASEKYEEGERALREAQ----QVQA 1003

Query: 784  AGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGG 843
               +RL QA  QQ  R+ +  +    +HL   Q +R++  + R+    S      R  G 
Sbjct: 1004 EQQARL-QAVQQQQERLRKQEQHMHQEHLSLAQ-QRLQLDRARQDLPSSLVGLFPRAQGP 1061

Query: 844  AHETSQAV-----HQRMLSQQKRFLAQFPVHQQMRL----HAQQQQAGVMDLLEAQLETQ 894
            A  +  A+       R  SQ    L   P+H   RL    H  +Q    ++  +  LET 
Sbjct: 1062 AASSQSALMPPAPTTRWCSQPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQFFLET- 1120

Query: 895  LQEAEQNFISELA 907
            L++   N  S  A
Sbjct: 1121 LKKGSYNLTSHSA 1133



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 57/246 (23%), Positives = 98/246 (39%), Gaps = 25/246 (10%)

Query: 699 LEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLV---HARNA 755
           L AR L +    E+   +   Q Q+RL A AQE  Q +++  E      L +   H    
Sbjct: 653 LSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQL 712

Query: 756 ATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDH----EERKLQH 811
                 KDR+    T   +   S+      + +   + ++   R+   H    +ER+L  
Sbjct: 713 QRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQEREL-- 770

Query: 812 LKTLQGERMENYKLRKKQE-LSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQ 870
                G R  + +LR  QE L              +      +  L++Q R L Q    +
Sbjct: 771 -----GIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQ----E 821

Query: 871 QMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKP 930
           + R+ A+Q +A   + ++  LE Q +   Q    E A L R   A+S LL  ++ ++ K 
Sbjct: 822 RWRVTAEQSKA---ESMQRALEEQRKVTAQQMAMERAELER---AKSALLEEQKSVMLKC 875

Query: 931 LRTKRK 936
              +R+
Sbjct: 876 GEERRR 881


>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
          Length = 1154

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 137/661 (20%), Positives = 259/661 (39%), Gaps = 126/661 (19%)

Query: 228 LRQEKHMMF--IQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEK----------- 274
           + QE H+    IQ  +    D   + +SD    Q+ L + + +LE++E+           
Sbjct: 139 IEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIAS 198

Query: 275 -GLQVKLSNTEMSGA-GDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQF 332
              ++++ ++E SG+ G S+Y  L +  ++ RE    L +   A  +  +++   L D  
Sbjct: 199 LRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLE 258

Query: 333 KCSSSKARQLMMTLTERMIAAEGLLCDSQELQA--LDALERTMGRAHMAKVIEFLKLQVQ 390
              + +A       TER + ++ L   S E Q   +D LE       + + +   + Q+ 
Sbjct: 259 SERTQRA-------TERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMH 311

Query: 391 ------EETRCRLAAISHGLELLAGEGK-----LSGRQKEELLTQQHKAFWQEAERFSRE 439
                 +E  C L  + H  ++   E +     L   Q E L  Q   +  Q  E  SR 
Sbjct: 312 GMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRL 371

Query: 440 FVQRGK---------DLVTASLAHQVE----GTAKLTLAQEEEQRSFLAEAQP------- 479
              + K         +L+   L  Q E       K TL + + ++  L   Q        
Sbjct: 372 CTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQN 431

Query: 480 -TADPEKFLEAFHEVLERQRLMQCDLE---------EEENVRATEAVVAL--CQELYFST 527
            T + EK LE   ++ E  +  + +L+         +E N + TE    L   ++LY ++
Sbjct: 432 VTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQAS 491

Query: 528 VDTFQK--------FVDALFLQ----------TLPGMTGLPPEECDYLRQEVQENAAWQL 569
            D  ++          D L  Q           +P   G    +CD L   + E      
Sbjct: 492 KDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTE------ 545

Query: 570 GKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLR-EDHEGTIRGVLGRLGGLTE 628
                  ++++K  Q+ + Q Q   ME+C L   L+   R ++ +G ++  L RL  L  
Sbjct: 546 ------LQEKYKASQKEMGQLQ---MEQCEL---LEDQRRMQEEQGQLQEELHRL-TLPL 592

Query: 629 ESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQE----LREQRALEQGS 684
             +  +L+  +LL +  L  L      L  L Q     +K L+Q     L+EQ  + +  
Sbjct: 593 PKSGLLLKSQELLTK--LEDLC----ELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEEL 646

Query: 685 SQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAI 744
            +  + H  ++L   +   L ++S+     Q   L  Q + L    + GQ  Q+ ++   
Sbjct: 647 RRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQ 706

Query: 745 GQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDH 804
           G+ L         + R + + D +  L E  ++ + V S  +   +++Y +  G ++  +
Sbjct: 707 GRLL---------EERKRLQADLQLCLEE--MQLLQVQSPSIKMSLESYGKSYGSMVPSN 755

Query: 805 E 805
           E
Sbjct: 756 E 756



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 132/598 (22%), Positives = 232/598 (38%), Gaps = 108/598 (18%)

Query: 391 EETRCRLAAISHGLEL---LAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDL 447
           EE R ++  +   LE    LAG+ +    + + LL  +  A  Q+AE F+++  Q   +L
Sbjct: 59  EELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGEL 118

Query: 448 VT-----ASLAHQVEGTAK-----LTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQ 497
            +     + L H+ E   K     L LAQ E Q    A      + E  + +  E L R 
Sbjct: 119 RSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCR- 177

Query: 498 RLMQCDLEEEENVRA--TEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECD 555
             MQ +LE+ E +R      + +L  E+   + +       +L L    G+     EE  
Sbjct: 178 --MQNELEDMERIRGDYEMEIASLRAEMEMKSSEP----SGSLGLSDYSGL----QEELQ 227

Query: 556 YLR-------------QEVQENAAWQLG--KSNRFRR--QQWKLFQEL------LEQDQQ 592
            LR             QE   +   QL   +S R +R  ++W   Q L       +  + 
Sbjct: 228 ELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEM 287

Query: 593 VWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRL--- 649
            ++E      +L+  LR D E  + G+  +   L  E     LQ H  +     RRL   
Sbjct: 288 DFLEPDPEMQLLRQQLR-DAEEQMHGMKNKCQELCCELEE--LQHHRQVSEEEQRRLQRE 344

Query: 650 -------ALRGNALATLTQ-MRLSGKKHLLQELREQRALEQG---SSQCLDEHQWQLLRA 698
                   LR     ++TQ   L  +   LQ+  +    EQ      Q   + + + L+ 
Sbjct: 345 LKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKV 404

Query: 699 LEARVLEEASRLEEEAQQTRLQLQ-QRLLAEAQ---EVGQLLQQHMECAIGQALLVHARN 754
           +++ ++E  S  E   +  +L LQ Q +  E +   E  Q LQ+ ++C   +A L H R+
Sbjct: 405 MKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQC--HEAELQHLRD 462

Query: 755 AATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKT 814
                +  +  D +             T A +  + Q Y     +  +D  ER+      
Sbjct: 463 TVASFKESNEKDTE-------------THAQLQEMKQLY-----QASKDELERQKHMYDQ 504

Query: 815 LQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRL 874
           L+ + +      K+ + S+P    +  G        +  R+   Q+++            
Sbjct: 505 LEQDLLLCQLELKELKASHPIPEDK--GKCANKCDTLLSRLTELQEKY------------ 550

Query: 875 HAQQQQAGVMDLLEAQL---ETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEK 929
            A Q++ G + + + +L   + ++QE +     EL  L  +PL +S LL   + LL K
Sbjct: 551 KASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLT-LPLPKSGLLLKSQELLTK 607


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 126/641 (19%), Positives = 261/641 (40%), Gaps = 83/641 (12%)

Query: 217 HLKDLLHL----DTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEEL 272
           HL+ LL      ++ LR+E H  F           L   ++  E+    +S  E+ L +L
Sbjct: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKAL---QTVIEMKDSKISSMERGLRDL 401

Query: 273 EKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNM-------EAFWKQMANIQ 325
           E+ +Q+  SN  +S     E +   +V +   ++ +  ++ +       EA W+++    
Sbjct: 402 EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKA 461

Query: 326 HFL---VDQFKCSSSKARQLMMTLTERMIAAEGLLCDS-QELQAL-DALERTMGRAHMAK 380
             L   + Q K   S+    ++ L  ++        DS Q ++ L ++L     RA + +
Sbjct: 462 AGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 521

Query: 381 V-IEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGR---QKEELLTQQHKAFWQEAERF 436
             ++ L+L+++E+            ++   +G  +G     K+ L  ++ K    + +  
Sbjct: 522 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 581

Query: 437 SREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLER 496
           + +   R K+   +SL  +V+     T    +   + L EA   A+ E+ +E   E  +R
Sbjct: 582 NLQEQLRDKEKQMSSLKERVKSLQADT-TNTDTALTTLEEA--LAEKERTIERLKEQRDR 638

Query: 497 QRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDY 556
                 + E++E +                  D ++K +  L  +       L  +E   
Sbjct: 639 D-----EREKQEEI------------------DNYKKDLKDLKEKVSLLQGDLSEKEASL 675

Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTI 616
           L  +++E+A+  L  S   +  + K  +  LEQ +    EEC     +++ L++ HE  +
Sbjct: 676 L--DLKEHAS-SLASSGLKKDSRLKTLEIALEQKK----EECLK---MESQLKKAHEAAL 725

Query: 617 RG-----VLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLL 671
                  +  R+  L  E TR   +      ++ + RL      +    +   + K   +
Sbjct: 726 EARASPEMSDRIQHLEREITR--YKDESSKAQAEVDRLL----EILKEVENEKNDKDKKI 779

Query: 672 QELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQE 731
            EL E++  +Q       +H+ Q+ +   A++LEEA R E+    +  QLQ  L  +   
Sbjct: 780 AEL-ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR 838

Query: 732 VGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
           + +L          +AL    +  A +     +++  RT  E  VE + +    V + ++
Sbjct: 839 IEEL---------EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 889

Query: 792 AYYQQIGRIMEDHEERKLQHLKTLQGERMENYK--LRKKQE 830
           +   ++    +   E++  HL  L+ ER ++ +  L  KQE
Sbjct: 890 SMKAKLSSTQQSLAEKE-THLTNLRAERRKHLEEVLEMKQE 929


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 90/396 (22%), Positives = 147/396 (37%), Gaps = 74/396 (18%)

Query: 642  LRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEA 701
            LRS L +     N L   +    S    L  EL ++R   + +SQ LD            
Sbjct: 1266 LRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDA----------- 1314

Query: 702  RVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRA 761
               E A RL  E +   LQ Q   L +  EV       ME  + +A L+ A     +   
Sbjct: 1315 ---ETAERLRAEKEMKELQTQYDALKKQMEV-------MEMEVMEARLIRAAEINGEVDD 1364

Query: 762  KDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYY--------------QQIGRIMEDHEE- 806
             D     R   E AV  V  T     RL Q +               +++G +  D EE 
Sbjct: 1365 DDAGGEWRLKYERAVREVDFTK---KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEES 1421

Query: 807  -RKLQHLKT---------------LQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQ- 849
             R LQ LK                L+G+++ N++L KKQ   +          AHE +Q 
Sbjct: 1422 QRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQ-----AHEEAQR 1476

Query: 850  -AVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAA 908
              + +  L ++K  L       + +L  +             LE +LQ+       + A+
Sbjct: 1477 EKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEAS 1536

Query: 909  LARVPL----AESKLLPAKRGLLEK----PLRTKRKKPLPQERGDLGVPNNEDLASGD-- 958
            LA+V       E+K+   +  L E+     +  + K  L  E   +   +++++ S D  
Sbjct: 1537 LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEE 1596

Query: 959  -QTSGSLSSKRLSQQESEAGDSGNSK-KMLKRRSNL 992
             + +     K+L Q E +  +    K K+L+ +  L
Sbjct: 1597 VEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1632



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 124/562 (22%), Positives = 220/562 (39%), Gaps = 92/562 (16%)

Query: 252  KSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLI 311
            ++D E  Q+ L + +K  + L   LQ    +T++   G  + +   ++EKK+R +  +L 
Sbjct: 1415 QADSEESQRALQQLKKKCQRLTAELQ----DTKLHLEG--QQVRNHELEKKQRRFDSELS 1468

Query: 312  DNMEAFWK---QMANIQH----FLVDQFKCSSSKARQLM--MTLTERMIAAEGLLCDSQE 362
               E   +   Q   +Q      L + F        + M     T+++++ E  L D   
Sbjct: 1469 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISS 1528

Query: 363  LQALDALERTMGRAHMAKVIEFL-----KLQVQEETRCRLAAISHGLELLAGEGKLSGRQ 417
             ++ D        A +AKV + L     K++ QEE     A     LE    + KL    
Sbjct: 1529 QESKD-------EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLE----QAKLRLEM 1577

Query: 418  KEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEA 477
            + E + Q H          S+E   R +++  A  + Q +   ++ +  EEE        
Sbjct: 1578 EMERMRQTH----------SKEMESRDEEVEEARQSCQKK-LKQMEVQLEEEYEDKQKVL 1626

Query: 478  QPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRA----TEAVVALCQELYFSTVDTFQK 533
            +   + E  L    + + R+     D E E+ +R     T+A++A  Q            
Sbjct: 1627 REKRELEGKLATLSDQVNRR-----DFESEKRLRKDLKRTKALLADAQ------------ 1669

Query: 534  FVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQV 593
                L L  L   +     E   L+ +++E+  +    + + R+      ++L  Q   +
Sbjct: 1670 ----LMLDHLKN-SAPSKREIAQLKNQLEESE-FTCAAAVKARKAMEVEIEDLHLQIDDI 1723

Query: 594  WMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRG 653
               + AL   L    RE +E     +  RL    E+    +++ H   +  A R LA   
Sbjct: 1724 AKAKTALEEQLSRLQREKNE-----IQNRLEEDQEDMNE-LMKKHKAAVAQASRDLAQIN 1777

Query: 654  NALATLTQMRLSGKK--HLLQELREQ-RALEQGS-SQCLDEHQWQLLRALEARVLEE--- 706
            +  A L +     ++    LQ L+ Q   LEQ    + L   Q   +R LE R+  E   
Sbjct: 1778 DLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ 1837

Query: 707  -------ASRLEEEAQQTRLQLQQRLLAEAQEVGQ--LLQQHMECAIGQALLVHARNAAT 757
                   ASRL+E  ++   +  QR+ AE +E  Q   LQ+ +     + +   AR  A 
Sbjct: 1838 VKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLR-DTKEEMGELARKEAE 1896

Query: 758  KSRAKDRDDFKRTLMEAAVESV 779
             SR K   +     +EAA +S+
Sbjct: 1897 ASRKKHELEMDLESLEAANQSL 1918


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 112/520 (21%), Positives = 211/520 (40%), Gaps = 76/520 (14%)

Query: 266  EKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQ 325
            EK  +EL+  LQV++ NT        E   L    +KE+E S QL   + +  +Q+   Q
Sbjct: 891  EKTCKELKHQLQVQMENTL------KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944

Query: 326  HFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFL 385
            + L    K +  + +QL   + E   ++E      Q+ + ++AL+  +  A + K     
Sbjct: 945  NTL----KQNEKEEQQLQGNINELKQSSE------QKKKQIEALQGELKIAVLQKTELEN 994

Query: 386  KLQVQ-EETRCRLAAISHGLELLAGEGKLS------------GRQKEELLTQQH-KAFWQ 431
            KLQ Q  +    LAA    + +L    + S            GR+ E L T+Q  K+  +
Sbjct: 995  KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054

Query: 432  EAERFSREFVQRGKDLVTASLAHQVEGTAKLTL----AQEEEQRSFLAEAQPTADPEKFL 487
            +      + +     +   +   Q   TAK TL    A++E+Q     +A      EK L
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114

Query: 488  EAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVD-----ALFLQT 542
            +    V E+ +L +    EE   R  + +  L +EL    +++ ++  +      L +Q 
Sbjct: 1115 KEKELVNEKSKLAEI---EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171

Query: 543  LPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSS 602
               + G    + D L+  V++    Q    ++ ++++ +L +E +E++ ++  E      
Sbjct: 1172 KLELQG----KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227

Query: 603  VLQTHLREDHEGT--IRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLA--------LR 652
             ++ H   + + T  I  +   LG + +E             +S+ RR++        LR
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKE------------WQSSQRRVSELEKQTDDLR 1275

Query: 653  GNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALE--ARVLEEASRL 710
            G     + +  +   +   + L E+    +G  + L     +L R L+     ++E  R 
Sbjct: 1276 GE--IAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333

Query: 711  EEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLV 750
             +  Q    Q   R  AE  EV    Q  M C  G ++ V
Sbjct: 1334 NQSLQIKHTQALNRKWAEDNEV----QNCMACGKGFSVTV 1369



 Score = 37.0 bits (84), Expect = 0.092
 Identities = 163/797 (20%), Positives = 299/797 (37%), Gaps = 142/797 (17%)

Query: 298  DVEKKEREYSEQLID--NMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEG 355
            D  K E +++E+ +   N++A   Q       L  +   S +   ++ + L+E+  A + 
Sbjct: 317  DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376

Query: 356  LLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLEL--------- 406
            L  +  E++            +     EF +LQ Q E + +     HGL+L         
Sbjct: 377  LKEELSEVET----------KYQHLKAEFKQLQQQREEKEQ-----HGLQLQSEINQLHS 421

Query: 407  --LAGE---GKLSGRQKEELLTQQHKAFWQEAE------RFSREFVQRGKDLVTAS--LA 453
              L  E   G+  GR KE+      K   +E +      + SR   ++ K+ VT S  L 
Sbjct: 422  KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR-LEEQLKEKVTNSTELQ 480

Query: 454  HQVEGTAKLTLAQEEEQRSFLA---EAQ--------PTADPEKFLEAFHEVLERQRLMQC 502
            HQ++ T +    Q+  Q+S  A   EAQ           D ++ ++    +L++ +    
Sbjct: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 503  DLEEEEN-----VRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYL 557
             LE+E       ++A E   A+  +L      T Q+ V  L  + L   +    +  + L
Sbjct: 541  LLEKEREDLYAKIQAGEGETAVLNQLQEKN-HTLQEQVTQL-TEKLKNQSESHKQAQENL 598

Query: 558  RQEVQENAAWQLGKSNRFRRQQW---KLFQELLEQDQQVWMEECALSSV----------- 603
              +VQE  A      +R    +    +L  +L E  ++V   +  + +            
Sbjct: 599  HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK 658

Query: 604  ------LQTHLR------EDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLAL 651
                  LQ HL       +D +  +  +  +L  +T +      Q H   L S L+    
Sbjct: 659  TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD--KQEHCSQLESHLKEYKE 716

Query: 652  RGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLE 711
            +  +L   T+      K L  +  E +A ++ + Q L + Q QL   LE R  E + +LE
Sbjct: 717  KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLE 775

Query: 712  EEAQ---QTRLQLQQRL---------LAEAQEVGQLLQQHMECAIGQALLVHAR-NAATK 758
             E +    TRL LQ++          L + +E  Q+L+Q  E    +  + H   N   +
Sbjct: 776  MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835

Query: 759  SRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHE---------ERKL 809
            +   +    K    EA +  +      +S++  +         ++++         E+  
Sbjct: 836  TTVTELQKVKME-KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894

Query: 810  QHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVH 869
            + LK     +MEN  L++++EL       + A    +      Q  L Q +  L Q    
Sbjct: 895  KELKHQLQVQMEN-TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953

Query: 870  QQM-----------------RLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARV 912
            +Q                  ++ A Q +  +  L + +LE +LQ+       ELA     
Sbjct: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA----- 1008

Query: 913  PLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQ 972
              AE + +   +   EK   T       Q + D     +E LA+            L+Q+
Sbjct: 1009 --AEKEKISVLQNNYEKSQET-----FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061

Query: 973  E--SEAGDSGNSKKMLK 987
            +  S     GN  K+++
Sbjct: 1062 DLISNRNQIGNQNKLIQ 1078


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 131/688 (19%), Positives = 272/688 (39%), Gaps = 91/688 (13%)

Query: 253  SDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLID 312
            +D ++  ++L  + K+L++    L+            + +   + +  K E E  ++ ++
Sbjct: 1945 TDAQIKNELLESEMKNLKKCVSELE------------EEKQQLVKEKTKVESEIRKEYLE 1992

Query: 313  NMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQA-LDALER 371
             ++   K+  N  H            A++L   L E+    + L  D    Q  + ALER
Sbjct: 1993 KIQGAQKEPGNKSH------------AKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040

Query: 372  TMGRAHMAKVIEFLKLQVQEE---TRCRLA-AISHG----LELLAGEGKLSGRQKEELLT 423
            T+      K +EF++ + Q++   T+  LA A+ H      EL + +  L   Q E    
Sbjct: 2041 TV------KALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094

Query: 424  QQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADP 483
                   ++  + ++E V+         L  ++E   +  L +++  +  L   +   + 
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR--REK 2152

Query: 484  EKFLEAFHEVLERQRLMQCDLEE-EENVRATEAVVALCQELYFSTVDTFQKFVDAL---- 538
                E   E+         ++++ +EN+ +T   +A   +   S  D   + +D      
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212

Query: 539  -----FLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQV 593
                  +Q+      L  + C  L+ ++++ +            ++ K+    LE D+Q+
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMS---------IHMEELKINISRLEHDKQI 2263

Query: 594  WMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVL---QGHDLLLRSALRRLA 650
            W  +      LQ  + +  +G  + +L +L     E TR +    Q     L S L+ L 
Sbjct: 2264 WESKAQTEVQLQQKVCDTLQGENKELLSQL-----EETRHLYHSSQNELAKLESELKSLK 2318

Query: 651  LRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLD--EHQWQLLRALEARVLEEAS 708
             +   L+   +     K +L   +R+Q A  Q S    +  E   Q  R L +R+ EE +
Sbjct: 2319 DQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEIN 2378

Query: 709  RLE----------EEAQQTRL-QLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAAT 757
              E          EEA Q  + +L+Q+   E +E+  LL Q  E    + +++   N   
Sbjct: 2379 MKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE----ENIVLEEENKKA 2434

Query: 758  KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLK-TLQ 816
              +     +  +T+ +  ++      + V + + +      RI+ D+++ + +HL   L+
Sbjct: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFV-KSMSSLQNDRDRIVGDYQQLEERHLSIILE 2493

Query: 817  GERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQF----PVHQQM 872
             +++      +  +L     G R+      +  A     L Q +  L Q        Q+ 
Sbjct: 2494 KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQ 2553

Query: 873  RLHAQQQQAGVMDLLEAQLETQLQEAEQ 900
             L  Q QQ   ++   A+LE +L+E+E+
Sbjct: 2554 LLEVQLQQNKELENKYAKLEEKLKESEE 2581



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 164/889 (18%), Positives = 332/889 (37%), Gaps = 147/889 (16%)

Query: 52   RQRTRHQKDDTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNIT 111
            R+  + QKDD   L +  +  ++     G   R+ + +V+ S D +       PS     
Sbjct: 1202 REELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKL------PSTDQQE 1255

Query: 112  AFALKAKVIYPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSL---------- 161
            + +    +  P+   F+      + P L  NL     P  P  +  +S+L          
Sbjct: 1256 SCSSTPGLEEPL---FKATEQHHTQPVLESNL----CPDWPSHSEDASALQGGTSVAQIK 1308

Query: 162  GSLSQGEKDDCSSSSSVHSATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDL 221
              L + E +       V S TS+   L++    V    E +  + ++++      H  ++
Sbjct: 1309 AQLKEIEAEKVELELKVSSTTSE---LTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365

Query: 222  LHLDTALRQEKHMMFIQIFKM-CLLDLLPKKKSDDELYQKILSKQEKDLEEL-----EKG 275
             H ++ L+Q+     +QI  +  L +L PK    DEL QK++SK+E+D+  L     EK 
Sbjct: 1366 -HAES-LQQKLESSQLQIAGLEHLRELQPKL---DEL-QKLISKKEEDVSYLSGQLSEKE 1419

Query: 276  LQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCS 335
              +    TE+    D        +E + +E+ E+ I  ++    +M      + ++ +  
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDER-IKQLQVELCEMKQKPEEIGEESRAK 1478

Query: 336  SSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRC 395
                R+L   L  R  A    L +++ LQ     E ++ R  + ++ + L      +   
Sbjct: 1479 QQIQRKLQAALISRKEA----LKENKSLQE----ELSLARGTIERLTKSL-----ADVES 1525

Query: 396  RLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQ 455
            +++A +   + + G   L   ++++L+T+  ++          + +    + +  +L   
Sbjct: 1526 QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSL------LENQSLSSSCESLKLALEGL 1579

Query: 456  VEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEA 515
             E   KL    E  + S +AE+    +  K L+  +E+L  Q       E E      EA
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL-LQSYENVSNEAERIQHVVEA 1638

Query: 516  VVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRF 575
            V    QELY     T                     +E +   QE ++       K  +F
Sbjct: 1639 VRQEKQELYGKLRSTEAN-----------------KKETEKQLQEAEQEMEEMKEKMRKF 1681

Query: 576  RRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVL 635
             + + +   EL E++ +                       +R  +   G   +E    +L
Sbjct: 1682 AKSKQQKILELEEENDR-----------------------LRAEVHPAGDTAKECMETLL 1718

Query: 636  QGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQL 695
               +  ++  L R+ +    L+   Q  +S K  L +E+++ +            HQ   
Sbjct: 1719 SS-NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLK------------HQ--- 1762

Query: 696  LRALEARVLEEAS--RLEEEAQQTRLQLQ--QRLLAEAQEVGQLLQQHMECAIGQALLVH 751
               +E  V ++A+    E+   QT +  +  Q +  E +E   L                
Sbjct: 1763 ---IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAK 1819

Query: 752  ARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQH 811
            + N A        D+    L +  ++ +    AG+    Q   ++  + +E+ +   L  
Sbjct: 1820 SANPAVSKDFSSHDEINNYLQQ--IDQLKERIAGLEEEKQK-NKEFSQTLENEKNTLLSQ 1876

Query: 812  LKTLQGE---------RMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRF 862
            + T  GE         +M     + ++ELS  +    T   A E    + +R+++Q    
Sbjct: 1877 ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET---AEEEKDDLEERLMNQLAEL 1933

Query: 863  LAQFPVHQQMRLHAQQQQAGVMDLLEAQLE------TQLQEAEQNFISE 905
                  + Q    AQ +     +LLE++++      ++L+E +Q  + E
Sbjct: 1934 NGSIGNYCQDVTDAQIKN----ELLESEMKNLKKCVSELEEEKQQLVKE 1978



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 123/539 (22%), Positives = 215/539 (39%), Gaps = 89/539 (16%)

Query: 390 QEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQE---AERFSREFVQRGKD 446
           QE+ + RLA      E L  E K   RQK+  L Q+ +A  +E   A+   ++     K 
Sbjct: 47  QEDVQERLAYA----EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA 102

Query: 447 LVTASLAHQVE------GTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRL- 499
            +T SL   +E      GT   T  Q EEQ S   +   T +  +  +  H++ E++ L 
Sbjct: 103 KLT-SLNKYIEEMKAQGGTVLPTEPQSEEQLS-KHDKSSTEEEMEIEKIKHKLQEKEELI 160

Query: 500 --MQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYL 557
             +Q  L + +  +  ++   +  E +       Q+  +  F+ TL             L
Sbjct: 161 STLQAQLTQAQAEQPAQSSTEM--EEFVMMKQQLQEKEE--FISTLQAQ----------L 206

Query: 558 RQEVQENAAWQL--GKSNRFRRQ----QWKLFQELLEQDQQVWMEECALSSVLQTHLRED 611
            Q   E AA Q+   K  RF  Q    + +L Q + + D +  M++     VLQ  L E+
Sbjct: 207 SQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKL--RVLQRKL-EE 263

Query: 612 HEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLL 671
           HE ++ G    +  L +E T    +  + +L   L+++    N L    +      K LL
Sbjct: 264 HEESLVGRAQVVDLLQQELTAA--EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321

Query: 672 QELREQRALEQGSSQCLDEHQWQLLRA----------LEAR--VLEEASRLEEEA----- 714
           +++  + A  + S   L E    LL            LE+R   LE+  + E E      
Sbjct: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI 381

Query: 715 ---QQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTL 771
              Q+T  +LQ    A   +  +LLQ   E A+  A  +       + ++K+   F   L
Sbjct: 382 LSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRL 441

Query: 772 ----MEAAVESVY--VTSAGVSRLVQAYYQQI-GRIMEDHEERKLQHLKTLQGERM--EN 822
                E A ++ +  V + G   + +     +  R++E   E+    L +++ E +  EN
Sbjct: 442 PLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAEN 501

Query: 823 YKL-----------------RKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLA 864
            KL                 R+  E+S     ++ +  A E+ Q V +   SQ+ + L+
Sbjct: 502 EKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELS 560


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 92/489 (18%), Positives = 197/489 (40%), Gaps = 64/489 (13%)

Query: 248 LPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYS 307
           L  +  ++EL+ ++  +QE+ +   E+ +Q      E       +   + + E+K RE  
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQ------EWEEKIQEQEEKIREQEEKIREQE 334

Query: 308 EQLIDNMEAFWKQMANI--QHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQA 365
           E++    E  W++   +  Q  ++ + +    +  ++M    E+M   E ++ + +E   
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE--K 392

Query: 366 LDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQ 425
           +  LE  M   H  + I   + + QEE + R        E      +   R++EE + +Q
Sbjct: 393 IRELEEKM---HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449

Query: 426 HKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEK 485
            K  W++ E+                  H+ E        +EEE+R      Q   +  +
Sbjct: 450 EKKMWRQEEKI-----------------HEQEKI------REEEKR------QEQEEMWR 480

Query: 486 FLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPG 545
             E  HE  E  R  +   E+EE +R  E  V   +E      +  ++  + ++ Q    
Sbjct: 481 QEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI 540

Query: 546 MTGLPPEECDYLRQEV---QENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSS 602
                 E+ +  R+E    ++   W+  K      + W+  +++ EQ+++VW +E  +  
Sbjct: 541 R-----EQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE 595

Query: 603 VLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQM 662
             Q   R++ E  +     ++    E+     +Q  +  +R    +  +R     T  Q 
Sbjct: 596 --QEEKRQEQEEKMWKQEEKIREQEEK-----IQEQEEKIREQEEK--IREQEEMTQEQE 646

Query: 663 RLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQ 722
              G++      +E++  EQ  +    E +   +R  E ++ E+  ++ E  Q+  +Q Q
Sbjct: 647 EKMGEQEEKMCEQEEKMQEQEETMWRQEEK---IREQEKKIREQEEKIRE--QEEMMQEQ 701

Query: 723 QRLLAEAQE 731
           +  + E +E
Sbjct: 702 EEKMWEQEE 710



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 31/140 (22%), Positives = 57/140 (40%), Gaps = 14/140 (10%)

Query: 300 EKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCD 359
           E+K RE  E+  +  E  WKQ   I+            +  + +    E++   E  + +
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIR------------EQEEKIQEQEEKIREQEEKIRE 637

Query: 360 SQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKE 419
            +E+      E  MG        +  K+Q QEET  R        E    E +   R++E
Sbjct: 638 QEEMT--QEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695

Query: 420 ELLTQQHKAFWQEAERFSRE 439
           E++ +Q +  W++ E+   +
Sbjct: 696 EMMQEQEEKMWEQEEKMCEQ 715


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 74/351 (21%), Positives = 147/351 (41%), Gaps = 38/351 (10%)

Query: 259 QKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFW 318
           +K L +QEK+L E EK L+ +    E       +   + + E+K RE  E++    E  W
Sbjct: 320 EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379

Query: 319 KQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHM 378
           +Q   ++            +  Q M    ERM   +  L + +E       E+      +
Sbjct: 380 EQEKQMR------------EQEQKMRDQEERMWEQDERLREKEERMR----EQEKMWEQV 423

Query: 379 AKVIEFLKLQVQE-ETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFS 437
            K+ E  K+Q QE +TR +   +     +   E K+  R++EE + +Q +   ++ E   
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM--REEEETMREQEEKMQKQEENM- 480

Query: 438 REFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQ 497
             + Q  K+     L  Q E   +    QE+E++ +  E +   D E+      ++  ++
Sbjct: 481 --WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE-EKIRDQEEMWGQEKKMWRQE 537

Query: 498 RLMQCD---LEEEENVR--------ATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGM 546
           ++ + +    E+EE +R          E +    QE    T D  +K  +    + +   
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE---ERMRER 594

Query: 547 TGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEE 597
                EE + +R++ +E    Q  K      + W+  +++ EQ++++W +E
Sbjct: 595 EKKMREEEEMMREQ-EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644



 Score = 38.1 bits (87), Expect = 0.041
 Identities = 62/292 (21%), Positives = 114/292 (39%), Gaps = 44/292 (15%)

Query: 228 LRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSG 287
           +R+++  M+ Q  KM   D   K    +E  +K   +QEK   + E+ ++ +    E   
Sbjct: 539 MREQEDQMWEQEEKM--RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596

Query: 288 AGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLT 347
               E   + + E+K +E  E++ +  E  W+Q   +Q            +  + M    
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQ------------EQEEKMWEQE 644

Query: 348 ERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELL 407
           E+M   E  + + Q L                K+ E  K+Q QE             ++ 
Sbjct: 645 EKMWEQEEKMWEQQRLP-----------EQKEKLWEHEKMQEQE-------------KMQ 680

Query: 408 AGEGKLSGRQKEELLTQ-QHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQ 466
             E K+  ++K E  TQ Q K  W + +    E ++  +  +        E   K+   Q
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM---Q 737

Query: 467 EEEQRSFLAEAQPTADPEKFLEAFHEVLERQRL--MQCDLEEEENVRATEAV 516
           E+E++    E +     EK  E   ++ E+QRL   +  L E E ++  E +
Sbjct: 738 EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKI 789



 Score = 37.0 bits (84), Expect = 0.092
 Identities = 67/357 (18%), Positives = 149/357 (41%), Gaps = 35/357 (9%)

Query: 259 QKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFW 318
           +K + +QEK   + E+ +Q +    E       E  T+ + E+K ++  E + +  E  W
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 488

Query: 319 KQ--MANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRA 376
           +Q  +   +  L +Q K         M    E++   E  + D +E+      E+ M R 
Sbjct: 489 QQQRLPEQKEKLWEQEK---------MQEQEEKIWEQEEKIRDQEEMWGQ---EKKMWRQ 536

Query: 377 HMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQK-----------EELLTQQ 425
              +  E    + +E+ R +   +    E +  E K   ++K           EE + ++
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERM--EKKTQEQEKKTWDQEEKMREEERMRER 594

Query: 426 HKAFWQEAE--RFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADP 483
            K   +E E  R   E +Q  ++ +        E   K+   QE+E++ +  E +     
Sbjct: 595 EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKM---QEQEEKMWEQEEKMWEQE 651

Query: 484 EKFLEAFHEVLERQRLMQCD-LEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQT 542
           EK  E      ++++L + + ++E+E ++  E  +   +++   T +  +K  D   ++ 
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE 711

Query: 543 LPGMTGLPPE--ECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEE 597
              M     +  E + + +E +E    Q  K      + W+  +++ EQ++++W ++
Sbjct: 712 EESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 132/692 (19%), Positives = 265/692 (38%), Gaps = 77/692 (11%)

Query: 248  LPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSN-TEMSGAGDSEYITLADVEKKEREY 306
            L  ++S  +L   +  +QE+D E+  +  Q +  +  E       E       ++K +E 
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317

Query: 307  SEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQAL 366
             + L +  E   ++    + F  ++      + + L     +R    E L    Q  + L
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377

Query: 367  DALERTMGRAHMAKVI-EFLKLQVQE--------------ETRCRLAAISHGLELLAGEG 411
            +  +R   +    K + E  +L+ QE              E   +L+      +    E 
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437

Query: 412  KLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLT-----LAQ 466
            ++  +++E    ++ +   QE  R  RE  Q  ++     L H+ E   K       L +
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL-HRQERDRKFLEEEQQLRR 1496

Query: 467  EEEQRSFLAEAQPTADPE-KFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYF 525
            +E  R F  +   + +PE KFLE   + L RQ+  +  L+EE+ +R  E      Q    
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEE-EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ---- 1551

Query: 526  STVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQE 585
               D  +KF                  E + LRQE +E    +  +  +FR ++ K+ ++
Sbjct: 1552 ---DRDRKF-----------------REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591

Query: 586  -----LLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDL 640
                  +E +QQ+  +E       Q  LR++ +   R     L    E+      +    
Sbjct: 1592 EQERKFMEDEQQLRRQEG------QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645

Query: 641  LLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLR-AL 699
            L      R   R   L      +   ++ LLQE  EQ+   Q   +   E + QL R   
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER 1705

Query: 700  EARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKS 759
            E + L+E  +L  +  + + + +++L  E ++  QL +Q     I +   +       + 
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQ-EQLRRQERYRKILEEEQLRPEREEQQL 1764

Query: 760  RAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGER 819
            R ++RD  ++   E  +          S+     +++  ++ ++ EE++L+  +     R
Sbjct: 1765 RRQERD--RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822

Query: 820  MENYKL-------RKKQELSNP-------SSGSRTAGGAHETSQAVHQRMLSQQKRFLAQ 865
             E  +L       R +QE           ++  ++     E  Q   Q+   +++R L +
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882

Query: 866  FPVHQQMRLHAQQQQAGVMDLLEAQLETQLQE 897
              + +Q +   + +Q G +   E +   +L E
Sbjct: 1883 EHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 47/242 (19%), Positives = 102/242 (42%), Gaps = 17/242 (7%)

Query: 659 LTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTR 718
           L ++R  G++   Q+ RE+   +    Q  +E +W   R  E  + +E  +L+EE  Q +
Sbjct: 215 LLELRRKGREEKQQQRRER---QDRVFQEEEEKEW---RKRETVLRKEEEKLQEEEPQRQ 268

Query: 719 LQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVES 778
            +LQ+    E +++ +L +Q +     +      R    +   + +++ +R   E   E 
Sbjct: 269 RELQE----EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324

Query: 779 VYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGS 838
                    R  Q   ++  ++  + EER+ Q L+  Q E     +LR++QE        
Sbjct: 325 Q-------ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377

Query: 839 RTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEA 898
           R         Q   ++ L ++++   +  + ++ +L  +QQ      L   Q E + ++ 
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437

Query: 899 EQ 900
            +
Sbjct: 438 HE 439



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 114/537 (21%), Positives = 206/537 (38%), Gaps = 86/537 (16%)

Query: 388  QVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAF---WQEAERFSREFVQRG 444
            Q QEE R R  +     EL   E + + RQ++E   +Q + F   WQ  E+      +RG
Sbjct: 733  QEQEEKRRRRES-----ELQWQEEERAHRQQQE--EEQRRDFTWQWQAEEKS-----ERG 780

Query: 445  KDLVTAS--LAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEK----------FLEAFHE 492
            +  ++A   L  Q E   +    Q+ EQR FL E +      +          FLE   +
Sbjct: 781  RQRLSARPPLREQRERQLRAEERQQREQR-FLPEEEEKEQRRRQRREREKELQFLEEEEQ 839

Query: 493  VLERQRLMQCDLEE----EENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTG 548
            +  R+R  Q   EE    E+  R         Q+  +   +  ++    L+ +  P +  
Sbjct: 840  LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK--PALQE 897

Query: 549  LPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHL 608
               +E   L++E +E     L +  R +R++ +  ++  E++Q    EE  L    +   
Sbjct: 898  QLRKEQQLLQEEEEE-----LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952

Query: 609  REDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKK 668
            R++ E   R           +  +   +   LL     +R            +     ++
Sbjct: 953  RQERERQYR-----------KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001

Query: 669  HLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAE 728
             LL+E RE+R  ++   Q   + + Q          EE   L EE ++ RLQ ++R   E
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQ---------QEEEQLLREEREKRRLQERERQYRE 1052

Query: 729  AQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSR 788
             +E    LQQ  E  +G+      R    +   K+ +      ++   E +        R
Sbjct: 1053 EEE----LQQEEEQLLGEERETRRRQELERQYRKEEE------LQQEEEQLLREEPEKRR 1102

Query: 789  LVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETS 848
                  Q+  R   + EE + +  + L+ ER    + R++QEL              E  
Sbjct: 1103 -----RQERERQCREEEELQQEEEQLLREER----EKRRRQELERQYR-------EEEEV 1146

Query: 849  QAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISE 905
            Q   +++L ++     +  + +Q R   + QQ     LL  + E + QE E+ +  E
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQE-EEQLLREEQEKRRQERERQYREE 1202



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 98/477 (20%), Positives = 184/477 (38%), Gaps = 78/477 (16%)

Query: 466 QEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYF 525
           QEEE++ +          E+ L+   E  +RQR +Q   EEEE +R  E      QEL  
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQ--EEEPQRQRELQ---EEEEQLRKLER-----QELRR 288

Query: 526 STVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQE 585
              +  Q+       Q L     L  ++ +  R++ +E    Q  +  +  R++ +L +E
Sbjct: 289 ERQEEEQQ------QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342

Query: 586 LLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSA 645
             E+ +Q    E       Q   RE  E      L R     E+  R             
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEERREQQLRR-----EQQLR------------- 384

Query: 646 LRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLE 705
                 R   L    Q+R   +    Q+LR ++ L +         + QL R  + R  +
Sbjct: 385 ------REQQLRREQQLRREQQLRREQQLRREQQLRR---------EQQLRREQQLRREQ 429

Query: 706 EASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRD 765
           E  R E++ +Q R +  QRL  E +E    L++  E         H +    +   +D++
Sbjct: 430 EEERHEQKHEQERRE--QRLKREQEERRDWLKREEETER------HEQERRKQQLKRDQE 481

Query: 766 DFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKL 825
           + +R       E          R  Q   +Q  ++  + EER+ Q LK  + E     +L
Sbjct: 482 EERRERWLKLEEEE-------RREQQERREQ--QLRREQEERREQRLKRQEEEERLQQRL 532

Query: 826 RKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMD 885
           R +Q+L              E  +   Q +  ++++ L Q    Q+++   ++++  ++ 
Sbjct: 533 RSEQQL------------RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580

Query: 886 LLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQE 942
             E + + +L+  ++  + +      V   E +    +R   E+P   +R++ L  E
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637



 Score = 37.7 bits (86), Expect = 0.054
 Identities = 79/359 (22%), Positives = 141/359 (39%), Gaps = 31/359 (8%)

Query: 557 LRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTI 616
           LR+E Q     QL +  + RR+Q    ++ L ++QQ+  E+       +    + HE   
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442

Query: 617 RGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELRE 676
           R    RL    EE         D L R        +      L + +   ++    +L E
Sbjct: 443 REQ--RLKREQEER-------RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493

Query: 677 QRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQ-QTRLQLQQRLLAEAQEVG-Q 734
           +   EQ      +  + QL R  E R  +   R EEE + Q RL+ +Q+L  E +E   Q
Sbjct: 494 EERREQQ-----ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 735 LLQQHMECAIGQALLVHA--------RNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGV 786
           LL++  E  + Q              R+   K   + R    +   E  +E   +    V
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ-RLKREEV 607

Query: 787 SRLVQAYY-QQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAH 845
            RL Q    +Q  +  E  EER+ Q LK+ + E     +LR++Q+        R      
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-----E 662

Query: 846 ETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFIS 904
           E  + + QR+  + +    +  + ++ +  A+++    +   + QLE++    +    S
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721



 Score = 34.3 bits (77), Expect = 0.60
 Identities = 110/563 (19%), Positives = 203/563 (36%), Gaps = 102/563 (18%)

Query: 416  RQKEELLTQQHKAFWQEAERFSREFVQRG--KDLVTASLAHQVEGTAKLTLAQEEEQRSF 473
            R++E+L  ++ +   +E E+  R+  +R   KD        Q+ G       ++E ++ +
Sbjct: 931  REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990

Query: 474  LAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQK 533
              E +   + E+ L                 EE E  R  E       E  +   D  Q+
Sbjct: 991  REEEELQQEEEQLLR----------------EEREKRRRQE------WERQYRKKDELQQ 1028

Query: 534  FVDALFLQTLPGMTGLPPEECDYLRQE-VQENAAWQLGKSNRFRRQQ-----WKLFQELL 587
              + L L+       L   E  Y  +E +Q+     LG+    RR+Q     ++  +EL 
Sbjct: 1029 EEEQL-LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087

Query: 588  EQDQQVWMEE------------CALSSVLQTH----LREDHEGTIRGVLGRLGGLTEEST 631
            ++++Q+  EE            C     LQ      LRE+ E   R  L R     EE  
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE-- 1145

Query: 632  RCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEH 691
              V Q  + LLR    +                  ++ L ++ RE+  L+Q   Q L E 
Sbjct: 1146 --VQQEEEQLLREEPEKRR----------------RQELERQYREEEELQQEEEQLLREE 1187

Query: 692  QWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVH 751
            Q       E R  E   +  EE +  R + +QR   E Q      Q   E          
Sbjct: 1188 Q-------EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA------ 1234

Query: 752  ARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQH 811
             R+     + ++ + F R L ++ +              +   Q +  ++ + +ER  + 
Sbjct: 1235 VRDNKVYCKGRENEQF-RQLEDSQLRD------------RQSQQDLQHLLGEQQERDREQ 1281

Query: 812  LKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQ 871
             +    +R  ++   ++ E        R    + E  Q + +    +++R        ++
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341

Query: 872  MRLHAQQQQAGV----MDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGL- 926
             +L  ++++  +     D    + E + QE  + F+ E   L R    E K L  ++ L 
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE-RERKFLKEEQQLR 1400

Query: 927  ---LEKPLRTKRKKPLPQERGDL 946
                E+ LR  R +   +E   L
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQL 1423



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 46/271 (16%), Positives = 107/271 (39%), Gaps = 9/271 (3%)

Query: 672  QELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQE 731
            ++ R QR   +   Q L+E +    R    ++ EE   L+E+ ++ R Q Q+R      +
Sbjct: 818  EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ 877

Query: 732  VGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
            + +  ++       +  L        +   ++ ++ +R   E                +Q
Sbjct: 878  LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ 937

Query: 792  AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAV 851
               +Q+ R     EER+ +  +  + +  ++ KL++K+E        +      E     
Sbjct: 938  QEEEQLLR-----EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE 992

Query: 852  HQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALAR 911
             + +  ++++ L +    ++ R    ++Q    D L+ + E  L+E  +     L    R
Sbjct: 993  EEELQQEEEQLLRE--EREKRRRQEWERQYRKKDELQQEEEQLLREEREK--RRLQERER 1048

Query: 912  VPLAESKLLPAKRGLLEKPLRTKRKKPLPQE 942
                E +L   +  LL +   T+R++ L ++
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQ 1079


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 178/873 (20%), Positives = 342/873 (39%), Gaps = 124/873 (14%)

Query: 199  PEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELY 258
            P     +S  + L   +LH + L   D   R E     +   +  L D   ++++ +E  
Sbjct: 511  PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL 570

Query: 259  QKILSKQEKDL---EELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNME 315
            Q++  K +  +   E+ ++ +Q   S  E+     S       V +++ E   Q  + ++
Sbjct: 571  QRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQ 630

Query: 316  AFWKQMANIQHFLVDQFKCSSSKA-----------RQLMMTLTERMIAAEGLLCDSQELQ 364
            A  +++   +  L ++ + +               RQL     +R + A+ L+ + +E  
Sbjct: 631  AAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELV-EVREAL 689

Query: 365  ALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQ 424
            +   L+R M +A  A+V E L       T+                   +GR + EL   
Sbjct: 690  SRATLQRDMLQAEKAEVAEAL-------TKAE-----------------AGRVELELSMT 725

Query: 425  QHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPE 484
            + +A     E  S +        +  SLA       +L +AQ EE++S L   Q  A+ E
Sbjct: 726  KLRA-----EEASLQDSLSKLSALNESLAQDKLDLNRL-VAQLEEEKSALQGRQRQAEQE 779

Query: 485  KFLEAFHEVLERQRLMQCDLEEE---ENVRATEAVVALCQELYFSTVDTFQKFVDALF-- 539
              +       E++RL +  LE+E   + +  +  V    QE     + T +     L   
Sbjct: 780  ATVARE----EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ 835

Query: 540  LQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECA 599
            L  L        +E +  R+E Q     Q+    R  R++  L +E      Q+   E  
Sbjct: 836  LAQLSRQLSGREQELEQARREAQR----QVEALERAAREKEALAKEHAGLAVQLVAAERE 891

Query: 600  LSSVLQ--THLR---EDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSAL---RRLAL 651
              ++ +  T LR   E  EG++  V  +L  L     +   +G  LLL           L
Sbjct: 892  GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951

Query: 652  RGNALAT----------LTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEA 701
            R   +AT          + Q  +  ++     LREQRA  +   Q L   +    R LEA
Sbjct: 952  RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011

Query: 702  RVLEEASRLEEEAQQ--TRLQ------------LQQR-----LLAEAQEVGQL-LQQHME 741
               +  S+L+ E ++   RL+            LQQ      LLAE+++   L L++  +
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071

Query: 742  CAIGQALLVHARNAAT--------KSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAY 793
             A+ + L+    + AT        K  A+ R +  R+ + A    +    A       A+
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131

Query: 794  YQQIGRIMEDHEE---------RKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGA 844
             Q++ R+ E   +         R+ + L+T Q   +E+ +   ++EL       R +   
Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRT-QLRLLEDARDGLRRELLEAQRKLRES--- 1187

Query: 845  HETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFIS 904
             +  + V ++   + +R L +    ++    + ++    +   E++    L+ A ++   
Sbjct: 1188 -QEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE-RISLKLANEDKEQ 1245

Query: 905  ELAALARVPLAESKLLPAKR-GLLE-KPLRTKRKKPLPQERGDLGVPNNEDLASGDQTS- 961
            +LA L     A  K     R GL E +  R + ++ L + R  + + ++E+   G + + 
Sbjct: 1246 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1305

Query: 962  --GSLSSKRLSQQESEAGDSGNSKKMLKRRSNL 992
              G L+    +++ES     G  +++LK  ++L
Sbjct: 1306 LQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 130/541 (24%), Positives = 213/541 (39%), Gaps = 108/541 (19%)

Query: 399  AISHGLELLAGEGKLSGRQKEELLTQQHKAFWQ----EAERFSREFVQRGKDLVTA---- 450
            A+   L     E + + R+++EL TQ      Q    EAER S     R + L  A    
Sbjct: 1506 AVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSA--TSRARQLQKAVAES 1563

Query: 451  -----SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLE 505
                 S+  ++ G       QEE  R    E + T D    LE   +  E +  ++   E
Sbjct: 1564 EEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESE--LRASQE 1621

Query: 506  EEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENA 565
            +   ++A E  +   +      +D  +     L LQ               L  E+Q + 
Sbjct: 1622 KISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRS------------LEGELQRS- 1668

Query: 566  AWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLR---------EDHEGTI 616
              +LG S+R    Q +  Q+ ++  Q+   +    +  LQ  +          E+ EG +
Sbjct: 1669 --RLGLSDR--EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL 1724

Query: 617  RGVLGRLGGLTE---ESTRCVLQGHD--LLLRSALRRLALRGNALATLTQMRLSGKKHLL 671
            R    ++ GLTE   +S+  +    D  L L+ AL         L    Q RL   +  L
Sbjct: 1725 RD---KVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL----QERLDAARQAL 1777

Query: 672  QELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQE 731
             E R+Q       S  L E Q Q LR   A +  E  R+E E Q              Q+
Sbjct: 1778 SEARKQ-------SSSLGE-QVQTLRGEVADL--ELQRVEAEGQ-------------LQQ 1814

Query: 732  VGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQ 791
            + ++L+Q  E   G+A       AA  +  K +D+  R L++  + S+    A +    +
Sbjct: 1815 LREVLRQRQE---GEA-------AALNTVQKLQDE--RRLLQERLGSLQRALAQL----E 1858

Query: 792  AYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGS----RTAGGAH-E 846
            A  +++ R     E+ ++   +TL  +++E  KLR  ++    S+      RT  GA  E
Sbjct: 1859 AEKREVERSALRLEKDRVALRRTL--DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE 1916

Query: 847  TSQAVHQ-RMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLE------AQLETQLQEAE 899
             ++A  Q + L  Q   L Q     Q+ + AQQQQ  +   +E      AQ E  L+  E
Sbjct: 1917 LAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARE 1976

Query: 900  Q 900
            +
Sbjct: 1977 R 1977


>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 99/388 (25%), Positives = 163/388 (42%), Gaps = 59/388 (15%)

Query: 416 RQKEELLTQQHKAFWQEAERFSREFVQRGKD----LVTASLAHQVEGTAKLTLAQEEEQR 471
           R+ EE+     + F ++   F +  VQ  KD    L     AH+ E   +L  +Q++   
Sbjct: 36  REVEEI----RRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRRE-IQELLKSQQDHSA 90

Query: 472 SFLAEAQPTADPEKF-LEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDT 530
           S     +   +  +  +E+ +++LE  RL +  L E+   +  +A     Q  Y   +DT
Sbjct: 91  SVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKA-----QSFYERELDT 145

Query: 531 FQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQEL--LE 588
            ++    LF  T   +     +E D LR+E Q       G+    R+   KL  EL  ++
Sbjct: 146 LKR--SQLF--TAESLQASKEKEAD-LRKEFQ-------GQEAILRKTIGKLKTELQMVQ 193

Query: 589 QDQQVWMEEC-----ALS------SVLQTHLREDHEGTI------RGVLGRLGGLTEEST 631
            +    +++C     AL+       VLQ  L +  EG +      + V   L    E   
Sbjct: 194 DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARE--- 250

Query: 632 RCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKK----HLLQELREQRALEQGSSQC 687
           R   Q  DL+L+++   +         +T   L  +K      L +L E+RA  +  +Q 
Sbjct: 251 RLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS 310

Query: 688 LDEHQWQLLRALEARVLEEASRLEEEAQQTRLQ-LQQRLLAEAQEVGQLLQQHMECAIGQ 746
           LDE Q Q +  LE +V  EA R ++E  +  L+ LQ RL    +EV QL + H +     
Sbjct: 311 LDEEQKQQILELEKKV-NEAKRTQQEYYERELKNLQSRL---EEEVTQLNEAHSKTLEEL 366

Query: 747 ALLVHARNAATKSRA-KDRDDFKRTLME 773
           A   H    A  S A +D+   +  L E
Sbjct: 367 AWKHHMAIEAVHSNAIRDKKKLQMDLEE 394



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 110/556 (19%), Positives = 214/556 (38%), Gaps = 67/556 (12%)

Query: 260 KILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWK 319
           ++L KQ  D +E E  L  K    E   A        A  E+ +++ S+ ++        
Sbjct: 218 QVLQKQLDDAKEGEMALLSKHKEVESELA--------AARERLQQQASDLVLKASHIGML 269

Query: 320 QMANI-QHFLVDQFKCSSSKARQLMMTLTER--MIAAEGLLCDSQELQALDALERTMGRA 376
           Q   + Q   +   +   S+  + +  L E    + ++    D ++ Q +  LE+ +  A
Sbjct: 270 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEA 329

Query: 377 ------HMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFW 430
                 +  + ++ L+ +++EE      A S  LE LA +  ++         +  K   
Sbjct: 330 KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQ 389

Query: 431 QEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAF 490
            + E       Q  KD              KL L +++ Q     E       +K   A 
Sbjct: 390 MDLEE------QHNKD--------------KLNLEEDKNQLQQELENLKEVLEDKLNTAN 429

Query: 491 HEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLP 550
            E+   Q +++   + E+ + + E ++A  Q+      +      D+L  +T   +  + 
Sbjct: 430 QEIGHLQDMVR---KSEQGLGSAEGLIASLQDSQERLQNELDLTKDSL-KETKDALLNVE 485

Query: 551 PEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQV-WME----ECALSSVLQ 605
            E    L QE Q++      ++    +++ KL  + +  D ++ W E    EC   S L+
Sbjct: 486 GE----LEQERQQHE-----ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQEC---SKLR 533

Query: 606 THLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLAL-RGNALATLTQMRL 664
             LR  HE   +  + +L  L +             +   L +++L + N    L+Q + 
Sbjct: 534 EELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQT 593

Query: 665 SGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRL---QL 721
           S ++   Q  +E++ L Q   +  ++HQ +     EA VL   +  EE+ ++ R     L
Sbjct: 594 SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 653

Query: 722 QQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYV 781
           QQ+  AE Q    L   H E   G    +         R +  D+ K  L     E  + 
Sbjct: 654 QQKHSAELQS---LKDAHRESMEG--FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 708

Query: 782 TSAGVSRLVQAYYQQI 797
            +A +  L   ++Q++
Sbjct: 709 HAAAIDLLRHNHHQEL 724



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 88/404 (21%), Positives = 162/404 (40%), Gaps = 57/404 (14%)

Query: 134 SSNPSLHENLKQAVLPHQPV--EASPSSS------LGSLSQGEKDDCSSSSSVHSATSDD 185
           S   SL E  KQ +L  +    EA  +        L +L    +++ +  +  HS T ++
Sbjct: 306 SKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEE 365

Query: 186 RFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLD---TALRQEKHMMFIQIFKM 242
               +  + + A       +   + + +   H KD L+L+     L+QE     ++  K 
Sbjct: 366 -LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQE-----LENLKE 419

Query: 243 CLLDLLPKKKSDDELYQKILSKQEK----------DLEELEKGLQVKLSNTEMSGAGDSE 292
            L D L     +    Q ++ K E+           L++ ++ LQ +L  T+ S     +
Sbjct: 420 VLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKD 479

Query: 293 YITLADVE-KKEREYSEQLIDNMEAFWK-QMANIQHFL----VDQFKCSSSKARQLMMTL 346
            +   + E ++ER+  E+ I  M+   K ++  + H L     +  +   SK R+ +   
Sbjct: 480 ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL--- 536

Query: 347 TERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLEL 406
             R+   E       +L  L   E+   R    K +E L  Q+        + +   LE+
Sbjct: 537 --RLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQI--------SLLKQNLEI 586

Query: 407 LAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTAS-LAHQVEGTAKLTLA 465
              + + S +Q +   TQ+ +   QE E    +  QR K L  A  LA Q     K    
Sbjct: 587 QLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEK---- 642

Query: 466 QEEEQRSFLAEAQP--TADPEKFLEAFHEVLERQRLMQCDLEEE 507
            E+EQR+     Q   +A+ +   +A  E +E  R+   ++E+E
Sbjct: 643 -EKEQRALENHLQQKHSAELQSLKDAHRESMEGFRI---EMEQE 682


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.129    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,480,558
Number of Sequences: 37866
Number of extensions: 1594032
Number of successful extensions: 9606
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 375
Number of HSP's that attempted gapping in prelim test: 8180
Number of HSP's gapped (non-prelim): 1324
length of query: 992
length of database: 18,247,518
effective HSP length: 112
effective length of query: 880
effective length of database: 14,006,526
effective search space: 12325742880
effective search space used: 12325742880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.