Search of human proteins with 24497490

Search of human proteins with 24497490

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
         (551 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24497490 solute carrier family 22 member 4 [Homo sapiens]         1099   0.0  
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           860   0.0  
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        301   1e-81
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           266   4e-71
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   254   1e-67
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          250   2e-66
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       248   8e-66
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   246   5e-65
gi|166064021 solute carrier family 22 (organic anion transporter...   243   3e-64
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   241   2e-63
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          239   5e-63
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          234   1e-61
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   222   6e-58
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   219   4e-57
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       219   7e-57
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   214   1e-55
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          206   6e-53
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   180   3e-45
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   177   2e-44
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       177   3e-44
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       173   4e-43
gi|157426885 organic cation transporter like 4 [Homo sapiens]         166   5e-41
gi|42542386 solute carrier family 22 (organic anion/cation trans...   158   1e-38
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          155   7e-38
gi|153791484 putative UST1-like organic anion transporter [Homo ...   151   1e-36
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   127   2e-29
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   124   3e-28
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   120   4e-27
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       118   1e-26
gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo sap...   111   2e-24

>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score = 1099 bits (2842), Expect = 0.0
 Identities = 551/551 (100%), Positives = 551/551 (100%)

Query: 1   MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS 60
           MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS
Sbjct: 1   MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS 60

Query: 61  AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120
           AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
Sbjct: 61  AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120

Query: 121 QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ 180
           QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ
Sbjct: 121 QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ 180

Query: 181 TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFA 240
           TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFA
Sbjct: 181 TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFA 240

Query: 241 VGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKA 300
           VGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKA
Sbjct: 241 VGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKA 300

Query: 301 AKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALS 360
           AKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALS
Sbjct: 301 AKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALS 360

Query: 361 LDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPV 420
           LDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPV
Sbjct: 361 LDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPV 420

Query: 421 DYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVY 480
           DYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVY
Sbjct: 421 DYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVY 480

Query: 481 LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMET 540
           LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMET
Sbjct: 481 LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMET 540

Query: 541 EENPKVLITAF 551
           EENPKVLITAF
Sbjct: 541 EENPKVLITAF 551


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  860 bits (2221), Expect = 0.0
 Identities = 425/557 (76%), Positives = 482/557 (86%), Gaps = 6/557 (1%)

Query: 1   MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS 60
           MRDYDEV AFLGEWGPFQRLIFFLLSASIIPNGF G+S VFL  TPEHRCRVPDAANLSS
Sbjct: 1   MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 60

Query: 61  AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120
           AWRN++VPLRLRDGREVPHSC RYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
Sbjct: 61  AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120

Query: 121 QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ 180
           QDVYLST+VTEWNLVCED+WK PLT SLFFVGVLLGSF+SGQLSDRFGRKNVLF TM +Q
Sbjct: 121 QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ 180

Query: 181 TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFA 240
           TGFSFLQIFS ++EMF VLFV+VGMGQISNYV AF+LGTEILGKSVRIIFSTLGVC F+A
Sbjct: 181 TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA 240

Query: 241 VGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKA 300
            GYM+LPLFAYFIRDWRMLL+ALT+PGVLCV LWWFIPESPRWLISQ RF EAE II+KA
Sbjct: 241 FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA 300

Query: 301 AKMNNIAVPAVIFD--SVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFA 358
           AK N I VP+ IFD   +++L+  KQQ   ILDL RT NI ++TIMS++LWM  SVGYF 
Sbjct: 301 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 360

Query: 359 LSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLV 418
           LSLD PNLHGD ++NCFLSA++E+PAY+ AWLLL+ LPRRY +A  LF GG VLLF+QLV
Sbjct: 361 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV 420

Query: 419 PVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYF 478
           P D Y+L+  LVM+GKFG+T+AFSM+YV+TAELYPT+VRNM VGV+STASR+GSI++PYF
Sbjct: 421 PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF 480

Query: 479 VYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGK---KTR 535
           VYLGAY+R LPYI+MGSLT+L  ILTLF PES G  LP+T++QM +VK  +  K    TR
Sbjct: 481 VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR 540

Query: 536 DSMETEENPKVL-ITAF 551
              + +E P +L  TAF
Sbjct: 541 MLKDGQERPTILKSTAF 557


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  301 bits (771), Expect = 1e-81
 Identities = 186/569 (32%), Positives = 304/569 (53%), Gaps = 39/569 (6%)

Query: 2   RDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP-------- 53
           R ++ +   +G +G FQR+++F+ +   I  G + ++ VF+  TP H CR P        
Sbjct: 4   RHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVF 63

Query: 54  ---------DAANLSSAWRNNSVPLRLRDGREVPHS-CSRYRLATIANFSALGLEPGRDV 103
                    D   L S+ + + V ++L++G     S CSR +     N S+LG E     
Sbjct: 64  HNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRE---NTSSLGYEY---- 116

Query: 104 DLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQL 163
             G  ++  C+DG+ + Q+ + ST VT+WNLVC+  W   L   LF  GVLLGS   G  
Sbjct: 117 -TGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYF 175

Query: 164 SDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILG 223
           SDR GR+ VL+AT +    F     F++ +  F      + M      VV F+   E +G
Sbjct: 176 SDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIG 235

Query: 224 KSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDW---RMLLLALTVPGVLCVPLWWFIPES 280
              R  ++++ + +FFAVG +L+ L  Y +R W   +M+L  +TVP +LC    W +PE+
Sbjct: 236 MKSRT-WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCC---WVLPET 291

Query: 281 PRWLISQRRFREAEDIIQKAAKMNNIA------VPAVIFDSVEELNPLKQQKAFILDLFR 334
           P WL+S+ R+ EA+ I+   AK N  +      + ++        +P + QK  +  LF 
Sbjct: 292 PFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFY 351

Query: 335 TRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRT 394
             +I   T+   L+W   S+G+++ SL++ NL G+ YLN FL  ++EIPAY    + +  
Sbjct: 352 NWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDK 411

Query: 395 LPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPT 454
           + RR ++A  LF        + ++P  +Y L +   M+GKF I +AF ++Y++TAELYPT
Sbjct: 412 VGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPT 471

Query: 455 LVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMT 514
           +VR++AVG  S   R+ SI+AP+ V L +    +P + +G++ +L G+LTL  PE+LG  
Sbjct: 472 IVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKR 531

Query: 515 LPETLEQMQKVKWFRSGKKTRDSMETEEN 543
           L  T E+  K++     K ++  + T  +
Sbjct: 532 LATTWEEAAKLESENESKSSKLLLTTNNS 560


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  266 bits (680), Expect = 4e-71
 Identities = 181/540 (33%), Positives = 270/540 (50%), Gaps = 16/540 (2%)

Query: 5   DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLS--SAW 62
           D+V+   GE+  FQ+ +FFLL+          + +VFL  TP+HRCR P  A LS    W
Sbjct: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGW 65

Query: 63  R-----NNSVPLRLRDGREVPHSCSRYRLA-TIANFSALGLEPGRDVDLGQLEQESCLDG 116
                 N +VP     G   P  C RY +    + F  +      D +  +L    C DG
Sbjct: 66  SPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDG 125

Query: 117 WEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFAT 176
           W +      S++VTE+NLVC ++W + L  S   VG  +GS   G ++DRFGRK  L  T
Sbjct: 126 WVYETPG--SSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183

Query: 177 MAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVC 236
           + +      L   S ++    +  +I G+   + +++ +IL TE +G+  R    T+G+ 
Sbjct: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYR---RTVGIF 240

Query: 237 --TFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAE 294
               + VG ++L   AY +  WR L   + +P    +  +W IPESPRWLISQ +  EA 
Sbjct: 241 YQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAM 300

Query: 295 DIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSV 354
            II+  AK N  ++PA +     E    K+     LDL RT  I   T++ +  W  +SV
Sbjct: 301 RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV 360

Query: 355 GYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLF 414
            Y  L +       + YL+ F SAL+E PA     L +  + RRY  AA     G   L 
Sbjct: 361 LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA 420

Query: 415 IQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSII 474
              +P D  +L I +  LG+ GIT A+ ++ +  AELYPT +RN+ V + S+   +G II
Sbjct: 421 SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII 480

Query: 475 APYFVY-LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKK 533
            P+ VY L      LP +V G L ++ G L L  PE+ G  LPET+E+ + ++  R  K+
Sbjct: 481 TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE 540


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  254 bits (649), Expect = 1e-67
 Identities = 189/555 (34%), Positives = 278/555 (50%), Gaps = 29/555 (5%)

Query: 1   MRDYDEVIAFLGEWGPFQR---LIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAAN 57
           M   D+++  +GE G FQ+   LI  LLSA+  P     + +VFL  TP+H C+ P  A 
Sbjct: 1   MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPIC---VGIVFLGFTPDHHCQSPGVAE 57

Query: 58  LSS--AWR-----NNSVPLRLRDGREVPHSCSRYRLATIANFSALG-LEPGRDV--DLGQ 107
           LS    W      N +VP     G      C RY +    N SAL  ++P   +  +   
Sbjct: 58  LSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDW--NQSALSCVDPLASLATNRSH 115

Query: 108 LEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRF 167
           L    C DGW +  D   S++VTE+NLVC D+WK+ L  S    G L GS   G  +DRF
Sbjct: 116 LPLGPCQDGWVY--DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF 173

Query: 168 GRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVR 227
           GRK  L  T+ V      L  FS ++    +  ++ G+    N++  + L TE +G   R
Sbjct: 174 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 233

Query: 228 IIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQ 287
              + +    F  VG + L   AY +  WR L LA+++P  L +  +W +PESPRWL+SQ
Sbjct: 234 RTVAIMYQMAF-TVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQ 292

Query: 288 RRFREAEDIIQKAAKMNNIAVPAVI-FDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSL 346
           +R  EA  I+   A+ N    PA +   S+EE    K   +F  DLFRT  +   T + +
Sbjct: 293 KRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFA-DLFRTPRLRKRTFILM 351

Query: 347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 406
            LW   SV Y  L L      G+ YL+   SAL+EIP    A + +  + R Y +A    
Sbjct: 352 YLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNL 411

Query: 407 WGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTST 466
             G   L +  +  D ++L+I ++ +G+ GIT A  M+ +  AELYPT VRN+ V V S+
Sbjct: 412 LAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSS 471

Query: 467 ASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKV 525
              +G II P+ V+ L    + LP I+   L +L   +TL  PE+ G+ LPET++  + +
Sbjct: 472 LCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENL 531

Query: 526 KWFRSGKKTRDSMET 540
                G+K +    T
Sbjct: 532 -----GRKAKPKENT 541


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  250 bits (639), Expect = 2e-66
 Identities = 171/551 (31%), Positives = 280/551 (50%), Gaps = 42/551 (7%)

Query: 1   MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHR-CRVPDAANLS 59
           M  +DE +  +GE+G FQR +F LL  + +   F  + VVFL   P+H  CR P AA L+
Sbjct: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60

Query: 60  SA--------WRNNSVPLRLRDGREVPHSCSRYRLATIANFSA-----------LGLEPG 100
                     W   +   R  +  E    C RY L   AN SA           L   P 
Sbjct: 61  ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEA-ANDSASATSALSCADPLAAFPN 119

Query: 101 RDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVS 160
           R   L       C  GW ++Q    ST+V+E++LVC + W + LT ++  +G L G+F  
Sbjct: 120 RSAPL-----VPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTL 172

Query: 161 GQLSDRFGRKNVLFATMAVQTGFSFLQI-FSISWEMFTVLFVIVGMGQISNYVVAFILGT 219
           G  +DR+GR  V++    +  G + + + F+ ++ +F +   + G+     ++  +++ T
Sbjct: 173 GYAADRYGRI-VIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVT 231

Query: 220 EILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPE 279
           EI+G   R I   + +  FF +G ++LP  AYFI +W+ + LA+T+P  L +  +W +PE
Sbjct: 232 EIVGSKQRRIVGIV-IQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPE 290

Query: 280 SPRWLISQRRFREAEDIIQKAAKMNNIAVPA----VIFDSVEELNPLKQQKAFILDLFRT 335
           SPRWLI++++  +A  I+++ AK N   + +    +     E  NP        LDL RT
Sbjct: 291 SPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPS------FLDLVRT 344

Query: 336 RNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTL 395
             +   T++ +  W  ++V Y  L +    + G+ Y++ F+S ++E+P  +   L +  L
Sbjct: 345 PQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERL 404

Query: 396 PRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTL 455
            RR   AA     G   L    +P    +L   +  LG+ GIT AF ++Y+  +ELYPT 
Sbjct: 405 GRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTT 464

Query: 456 VRNMAVGVTSTASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMT 514
           +RN  V + S     G IIAP+ ++ L A    LP I+ G L  + G L +  PE+ G+ 
Sbjct: 465 LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIA 524

Query: 515 LPETLEQMQKV 525
           LPET++ ++K+
Sbjct: 525 LPETVDDVEKL 535


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  248 bits (634), Expect = 8e-66
 Identities = 158/431 (36%), Positives = 230/431 (53%), Gaps = 15/431 (3%)

Query: 115 DGWEFSQDVYLST----VVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRK 170
           +G E  + V+ S+    + +EW L+   ++KV   +S FF GV +G    GQLSDRFGRK
Sbjct: 80  NGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRK 139

Query: 171 NVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIF 230
            V     A+   F+    FS S+E F V   +VGM      +VAF+L  E +G +   + 
Sbjct: 140 KVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALA 199

Query: 231 STLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRF 290
            ++G   FFAVG     L  YFIR WR L + + + G +   L  FIPESPRWL SQ R 
Sbjct: 200 GSIGGL-FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRL 258

Query: 291 REAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWM 350
            EAE+ +   AK N        F      N   ++    LDLFR R +   T++ + +W 
Sbjct: 259 SEAEEALYLIAKRNRKL--KCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWF 316

Query: 351 LTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLL--RTLPRRYIIAAVLFWG 408
           + S+ Y+ L+L A +L G  Y N  LS LIEIP+Y     L+  +   R+  ++A L  G
Sbjct: 317 VCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLG 376

Query: 409 GGVLLFIQLVP------VDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVG 462
           G   L +  +P      V     S  L +LGK  I++AF+++Y++T+ELYPT++RN+ +G
Sbjct: 377 GLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLG 436

Query: 463 VTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQM 522
             S  SRVG IIAP+   L      LP+IV G+  +  G+L+L  PE+L   L ET   +
Sbjct: 437 TCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDL 496

Query: 523 QKVKWFRSGKK 533
           Q   + R G++
Sbjct: 497 QVYSYRRLGEE 507


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  246 bits (627), Expect = 5e-65
 Identities = 177/559 (31%), Positives = 266/559 (47%), Gaps = 39/559 (6%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDA-ANLS--S 60
           ++E++  +G +GPFQ     LL+   +    + +  +FLA  P HRC +P A AN S   
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62

Query: 61  AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES----CLDG 116
            W    +P   R+      SC R+        + LG E       G+LE E     C  G
Sbjct: 63  VWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQ---SRGELEDEPATVPCSQG 116

Query: 117 WEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFAT 176
           WE+    + ST+ TEW+LVCE        ++ FF GVL+G+   G LSDRFGR+ +L   
Sbjct: 117 WEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVA 176

Query: 177 MAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVC 236
                        S+S+ MF +   + G       ++   L  E L    R +   L   
Sbjct: 177 YVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLS-S 235

Query: 237 TFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVP----LWWFIPESPRWLISQRRFRE 292
           TF+  G MLL L  Y IRDWR LLLA+T+P   C P    LWW +PES RWL++Q   +E
Sbjct: 236 TFWTGGVMLLALVGYLIRDWRWLLLAVTLP---CAPGILSLWW-VPESARWLLTQGHVKE 291

Query: 293 AEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFI-----LDLFRTRNIAIMTIMSLL 347
           A   +   A++N   V    F S E ++ +   +  +     LDLFRT  +  +++  ++
Sbjct: 292 AHRYLLHCARLNGRPVCEDSF-SQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVV 350

Query: 348 LWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFW 407
           +W   +  Y+ LSLD   L  + Y    L   +E+P+ +  +L +R   RR   A  L  
Sbjct: 351 VWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL- 409

Query: 408 GGGVLLF--IQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTS 465
            G  L F    LV  D    S  L ++GK    +AF+  Y+FT+ELYPT++R   +G+T+
Sbjct: 410 -GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTA 468

Query: 466 TASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKV 525
              R+G  +AP    L      LP +  G + +L     L  PE+    LPET++ +++ 
Sbjct: 469 LVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER- 527

Query: 526 KWFRSGKKTRDSMETEENP 544
                 K    S++ EE P
Sbjct: 528 ------KSAPTSLQEEEMP 540


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  243 bits (621), Expect = 3e-64
 Identities = 172/550 (31%), Positives = 272/550 (49%), Gaps = 26/550 (4%)

Query: 1   MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP----DAA 56
           M  + +V+A +G++G FQ  +  LL      + F   + VF+     H C V        
Sbjct: 1   MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF 60

Query: 57  NLSSAWRNN-SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLD 115
           NLS+A +   SVPL   D    P  C  +R    AN S   +   R       E + C  
Sbjct: 61  NLSAAEQLVLSVPL---DTAGHPEPCLMFRPPP-ANASLQDILSHRFN-----ETQPCDM 111

Query: 116 GWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFA 175
           GWE+ ++  L ++  E+NLVC+       T S+F  G+L+G+ + G L DR GRK  + A
Sbjct: 112 GWEYPEN-RLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILA 170

Query: 176 TMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGV 235
            + + T       F  S+E++  L   V             L TE +G S R     L  
Sbjct: 171 QLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQ 230

Query: 236 CTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAED 295
           C F ++G M+L   AY  R+WR+L +  T PG+L    +W +PES RWL+++ R  EA  
Sbjct: 231 CNF-SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQ 289

Query: 296 IIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAF----ILDLFRTRNIAIMTIMSLLLWML 351
           +IQKAA +N   +      S E +N L  +K       LDLFR   +  +T++   +W +
Sbjct: 290 LIQKAASVNRRKL------SPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFV 343

Query: 352 TSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGV 411
            S+GY+ LSL   +   D YL   +   +E+PA  ++  +++   R++     L  GG +
Sbjct: 344 DSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLM 403

Query: 412 LLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVG 471
            + I  +P D   +   L ++GK    +AF++ YV++AEL+PT++R   +G+    SR+G
Sbjct: 404 CIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIG 463

Query: 472 SIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSG 531
            I+ P  + LG Y+  LP ++ GSL ++ G+L    PE+ G  L +TL+ ++     RS 
Sbjct: 464 GILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSP 523

Query: 532 KKTRDSMETE 541
           K      ETE
Sbjct: 524 KSVPSEKETE 533


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  241 bits (614), Expect = 2e-63
 Identities = 177/561 (31%), Positives = 266/561 (47%), Gaps = 41/561 (7%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDA-ANLS--S 60
           ++E++  +G +GPFQ     LL+   +    + +  +FLA  P HRC +P A AN S   
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62

Query: 61  AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES----CLDG 116
            W    +P   R+      SC R+        + LG E       G+LE E     C  G
Sbjct: 63  VWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQ---SRGELEDEPATVPCSQG 116

Query: 117 WEFSQDVYLSTVVTE--WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLF 174
           WE+    + ST+ TE  W+LVCE        ++ FF GVL+G+   G LSDRFGR+ +L 
Sbjct: 117 WEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLL 176

Query: 175 ATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLG 234
                          S+S+ MF +   + G       ++   L  E L    R +   L 
Sbjct: 177 VAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLS 236

Query: 235 VCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVP----LWWFIPESPRWLISQRRF 290
             TF+  G MLL L  Y IRDWR LLLA+T+P   C P    LWW +PES RWL++Q   
Sbjct: 237 -STFWTGGVMLLALVGYLIRDWRWLLLAVTLP---CAPGILSLWW-VPESARWLLTQGHV 291

Query: 291 REAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFI-----LDLFRTRNIAIMTIMS 345
           +EA   +   A++N   V    F S E ++ +   +  +     LDLFRT  +  +++  
Sbjct: 292 KEAHRYLLHCARLNGRPVCEDSF-SQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCC 350

Query: 346 LLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVL 405
           +++W   +  Y+ LSLD   L  + Y    L   +E+P+ +  +L +R   RR   A  L
Sbjct: 351 VVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTL 410

Query: 406 FWGGGVLLFIQ--LVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGV 463
              G  L F    LV  D    S  L ++GK    +AF+  Y+FT+ELYPT++R   +G+
Sbjct: 411 L--GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGL 468

Query: 464 TSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523
           T+   R+G  +AP    L      LP +  G + +L     L  PE+    LPET++ ++
Sbjct: 469 TALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528

Query: 524 KVKWFRSGKKTRDSMETEENP 544
           +       K    S++ EE P
Sbjct: 529 R-------KSAPTSLQEEEMP 542


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  239 bits (610), Expect = 5e-63
 Identities = 170/551 (30%), Positives = 263/551 (47%), Gaps = 40/551 (7%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63
           + E++  +G  G FQ L   +L   I+    + +  +F A TP H CR P  A+ +  W 
Sbjct: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNAS-TGPWV 61

Query: 64  NNSVPLRLRDGREVPHSCSRY---RLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS 120
               P    +G+  P  C R+     A++ N +   +EP             CLDGW ++
Sbjct: 62  LPMGP----NGK--PERCLRFVHPPNASLPNDTQRAMEP-------------CLDGWVYN 102

Query: 121 QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ 180
                 ++VTEW+LVC  N    +  S+F  G+L+G  V G LSDRFGR+ +L  +  + 
Sbjct: 103 STK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLL 160

Query: 181 TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFST-LGVCTFF 239
                   FS ++ ++ V   + G G     +   IL  E +   +R I ST LG C  F
Sbjct: 161 AASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTF 220

Query: 240 AVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQK 299
             G  +LP  AY I  WR L L +++P  +     W+ PES RWL+   +  +A  I+++
Sbjct: 221 --GQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278

Query: 300 AAKMNNIAVPAVIFDSVEELNPLKQQKAFIL--------DLFRTRNIAIMTIMSLLLWML 351
            A  N          S+EEL  L  QK   L        DLFR   +  MT    L W  
Sbjct: 279 VAVFNGKKEEGERL-SLEELK-LNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFA 336

Query: 352 TSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGV 411
           T   Y++L++       + Y+   +   +++PA     L L  L R    AA L   GG 
Sbjct: 337 TGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGA 396

Query: 412 LLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVG 471
           +L +  VP+D   +   L + GK  ++S+FS L+++T+ELYPT++R   +GV++  +RVG
Sbjct: 397 ILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVG 456

Query: 472 SIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSG 531
           S+++P     G     +P I+ G   +L G   LF PE+L   LPET+E ++   W    
Sbjct: 457 SMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLE--NWSLRA 514

Query: 532 KKTRDSMETEE 542
           KK +   E E+
Sbjct: 515 KKPKQEPEVEK 525


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  234 bits (598), Expect = 1e-61
 Identities = 162/539 (30%), Positives = 263/539 (48%), Gaps = 29/539 (5%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP-------DAA 56
           + E++  +G  G FQ L    L  SI+      M   F A  P HRC  P        A+
Sbjct: 3   FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQAS 62

Query: 57  NLSSAWRNNSVPLRLRDG-REVPHSCSRYRLATIANFSALGLEPGRDV-DLGQLEQESCL 114
            L S      + + +  G  + PH C R+R           L+P        + + E C+
Sbjct: 63  ILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQL-----LDPNATATSWSEADTEPCV 117

Query: 115 DGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVL- 173
           DGW + + ++ ST+V +WNLVC+ +   P+  S++  G+L+G+   G  SDRFGR+ VL 
Sbjct: 118 DGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLT 177

Query: 174 --FATMAVQ-TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIF 230
             +  MAV  T  +F   F + + +F  L      G + N     +  T    + + +  
Sbjct: 178 WSYLQMAVMGTAAAFAPAFPV-YCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTL 236

Query: 231 STLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRF 290
           ++LG    F+ G+ L    AY +RDW +L L ++VP  LC    W++ ES RWL++  R 
Sbjct: 237 NSLG----FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRL 292

Query: 291 REAEDIIQKAAKMN------NIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIM 344
                 + + A +N      +   P V+  ++ E   + Q  A +  L R   +   T +
Sbjct: 293 DWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCI 352

Query: 345 SLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAV 404
           S L W      +F L+LD   L  + +L      +++IPA + A LLL  L RR  +AA 
Sbjct: 353 STLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAAS 412

Query: 405 LFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVT 464
           L   G  +L   LVP +   L   L +LG  G+ +AF+ + ++++EL+PT++R  AVG+ 
Sbjct: 413 LLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLG 472

Query: 465 STASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523
             A+R G+I+ P    LG +   LP +V G++ VL G+  L  PE+  + LP+T++ +Q
Sbjct: 473 QMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQ 531


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  222 bits (566), Expect = 6e-58
 Identities = 152/546 (27%), Positives = 256/546 (46%), Gaps = 20/546 (3%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63
           +++++  +G  G FQ++   L+   ++    +     F A  P H CR P  ANLS   +
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59

Query: 64  NNSVPLRL-RDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
           N  + + L RD +  P SC R+           G E       G    E C DGW +   
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114

Query: 123 VYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTG 182
            + ST+VTEW+LVC       L  SL+ VGVLLG+ V G L+DR GR+ VL         
Sbjct: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAV 174

Query: 183 FSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVG 242
                 F+ ++ ++    ++ GM      +    L  E +    R    TL +   +++G
Sbjct: 175 SGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLG 233

Query: 243 YMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAK 302
             LL   AY +  WR L L ++ P        WF  ES RW  S  R       +Q+ A+
Sbjct: 234 QFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293

Query: 303 MNNIAVPA------VIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGY 356
           +N            V+  S+++   + + +A  ++L R   +  + +   +LW  TS  Y
Sbjct: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAY 353

Query: 357 FALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQ 416
           + L +D        YL   +   +++PA +  +L++ +L RR    A L   G  +L   
Sbjct: 354 YGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

Query: 417 LVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 476
           ++P D   +   L +LGK  + ++F+ ++++T ELYPT++R   +G+ ST +RVGSI++P
Sbjct: 414 VIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSP 473

Query: 477 YFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRD 536
                      +P  + G++ V    +T+  PE+LG  LP+T++ ++     R GK+TR 
Sbjct: 474 LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES----RKGKQTRQ 529

Query: 537 SMETEE 542
             E ++
Sbjct: 530 QQEHQK 535


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  219 bits (559), Expect = 4e-57
 Identities = 153/556 (27%), Positives = 258/556 (46%), Gaps = 27/556 (4%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63
           +++++  +G  G FQ++   L+   ++    +     F A  P H CR P  ANLS   +
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59

Query: 64  NNSVPLRL-RDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
           N  + + L RD +  P SC R+           G E       G    E C DGW +   
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114

Query: 123 VYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTG 182
            + ST+VTEW+LVC       L  SL+ VGVLLG+ V G L+DR GR+ VL         
Sbjct: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAV 174

Query: 183 FSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVG 242
                 F+ ++ ++    ++ GM      +    L  E +    R    TL +   +++G
Sbjct: 175 SGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLG 233

Query: 243 YMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAK 302
             LL   AY +  WR L L ++ P        WF  ES RW  S  R       +Q+ A+
Sbjct: 234 QFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293

Query: 303 MNNIAVPA------VIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGY 356
           +N            V+  S+++   + + +A  ++L R   +  + +   +LW  TS  Y
Sbjct: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAY 353

Query: 357 FALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQ 416
           + L +D        YL   +   +++PA +  +L++ +L RR    A L   G  +L   
Sbjct: 354 YGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

Query: 417 LVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 476
           ++P D   +   L +LGK  + ++F+ ++++T ELYPT++R   +G+ ST +RVGSI++P
Sbjct: 414 VIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSP 473

Query: 477 YFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWF-------- 528
                      +P  + G++ V    +T+  PE+LG  LP+T++ ++  +W         
Sbjct: 474 LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES-RWAPTQKEAGI 532

Query: 529 --RSGKKTRDSMETEE 542
             R GK+TR   E ++
Sbjct: 533 YPRKGKQTRQQQEHQK 548


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  219 bits (557), Expect = 7e-57
 Identities = 168/554 (30%), Positives = 252/554 (45%), Gaps = 35/554 (6%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGF---NGMSVVFLAGTPEHRCRVPD-----A 55
           + +++  LG  G FQ     LL   ++P G    +     F A  P H CR P      +
Sbjct: 3   FTDLLDALGSMGRFQLNHTALL---LLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAS 59

Query: 56  ANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLD 115
            N S AW   ++PL   D    P  C R+     A  S     PG          E C D
Sbjct: 60  TNDSGAWLRATIPL---DQLGAPEPCRRFTKPQWALLSPNSSIPGAAT-------EGCKD 109

Query: 116 GWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFA 175
           GW +++ V+ ST+V EW+LVCE      L  S++  GVL+G+ V G L+DR G K  L  
Sbjct: 110 GWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVW 169

Query: 176 TMAVQTGFSFLQIFSISWEMFTVLFVIVGM---GQISNYVVAFILGTEILGKSVRIIFST 232
           +            +  S+  + V   ++GM   G I N V   +      G++V  I   
Sbjct: 170 SYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGIL-- 227

Query: 233 LGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFRE 292
           LG    F +G ++L   AY IR WR L  A++ P ++     W++PES RWL+   + + 
Sbjct: 228 LGYS--FTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQL 285

Query: 293 AEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAF------ILDLFRTRNIAIMTIMSL 346
           A   +QK A MN               + ++ + A       ILDLFRT  I  +T   +
Sbjct: 286 AVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLM 345

Query: 347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 406
           ++W   SV Y+ L++D        YL   L  +I  PA + A   +  + RR  +A+ L 
Sbjct: 346 VIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLI 405

Query: 407 WGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTST 466
             G +++    VP     L      LGK  + S+F  +Y+FT ELYPT +R M +G  S 
Sbjct: 406 LAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASV 465

Query: 467 ASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ-KV 525
            +R+G + AP    LG Y+ +LP +  G+  +L G+      E+  M L ET+  M+ +V
Sbjct: 466 HARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRV 525

Query: 526 KWFRSGKKTRDSME 539
           K   S K   +  E
Sbjct: 526 KEGSSKKHVEEKSE 539


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  214 bits (546), Expect = 1e-55
 Identities = 165/486 (33%), Positives = 240/486 (49%), Gaps = 26/486 (5%)

Query: 1   MRDYDEVIAFLGEWGPFQR---LIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAAN 57
           M   D+++  +GE G FQ+   LI  LLSA+  P     + +VFL  TP+H C+ P  A 
Sbjct: 1   MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPIC---VGIVFLGFTPDHHCQSPGVAE 57

Query: 58  LSS--AWR-----NNSVPLRLRDGREVPHSCSRYRLATIANFSALG-LEPGRDV--DLGQ 107
           LS    W      N +VP     G      C RY +    N SAL  ++P   +  +   
Sbjct: 58  LSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDW--NQSALSCVDPLASLATNRSH 115

Query: 108 LEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRF 167
           L    C DGW +  D   S++VTE+NLVC D+WK+ L  S    G L GS   G  +DRF
Sbjct: 116 LPLGPCQDGWVY--DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF 173

Query: 168 GRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVR 227
           GRK  L  T+ V      L  FS ++    +  ++ G+    N++  + L TE +G   R
Sbjct: 174 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 233

Query: 228 IIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQ 287
              + +    F  VG + L   AY +  WR L LA+++P  L +  +W +PESPRWL+SQ
Sbjct: 234 RTVAIMYQMAF-TVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQ 292

Query: 288 RRFREAEDIIQKAAKMNNIAVPAVI-FDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSL 346
           +R  EA  I+   A+ N    PA +   S+EE    K   +F  DLFRT  +   T + +
Sbjct: 293 KRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFA-DLFRTPRLRKRTFILM 351

Query: 347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 406
            LW   SV Y  L L      G+ YL+   SAL+EIP    A + +  + R Y +A    
Sbjct: 352 YLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNL 411

Query: 407 WGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAV---GV 463
             G   L +  +  D ++L+I ++ +G+ GIT A  M+ +  AELYPT V  +     G 
Sbjct: 412 LAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVGPACRGS 471

Query: 464 TSTASR 469
            +T+SR
Sbjct: 472 DATSSR 477


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  206 bits (523), Expect = 6e-53
 Identities = 161/544 (29%), Positives = 260/544 (47%), Gaps = 36/544 (6%)

Query: 4   YDEVIAFLGEWGPFQRL--IFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSA 61
           + +++   G  G FQ L  + F+L   +IP+    +   F A  P HRC      N  SA
Sbjct: 3   FSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQM--LLENFSAAIPGHRCWTHMLDN-GSA 59

Query: 62  WRNNSVPLRLRD------GREVPHSCSRYRLATIANFSALGLEPGRDV-DLGQLEQESCL 114
              N  P  L          + PH C R+R           L+P        + + E C+
Sbjct: 60  VSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQL-----LDPNATATSWSEADTEPCV 114

Query: 115 DGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLF 174
           DGW + + V+ ST+V +W+LVC      PL+ S+F  G+L+GSF+ G LS RFGRK +L 
Sbjct: 115 DGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLS 174

Query: 175 ATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLG 234
                        IF+ ++ ++  L  +   G    ++ +  L  E    S R +  T+ 
Sbjct: 175 WCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVV 234

Query: 235 VCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAE 294
            C F A G   L   A+ +RDWR L LA +VP      + W++PES RWLI + +  +A 
Sbjct: 235 GCAFSA-GQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQAL 293

Query: 295 DIIQKAAKMN------NIAVPAVIFDSVEELNPLKQQKAFILDLF-----RTRNIAIMTI 343
             ++K A++N      N+ +  ++    EE+   K+ ++ +LDLF     R R+ A++ +
Sbjct: 294 QELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRS-VLDLFCVPVLRWRSCAMLVV 352

Query: 344 MSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAA 403
              LL     + Y+ L  D  +L  D +L   L   ++     T  LLL  L RR I A 
Sbjct: 353 NFSLL-----ISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAG 407

Query: 404 VLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGV 463
                G  +L   LVP D   L +   +LGK     + + L ++ AEL+PT VR  A G+
Sbjct: 408 SQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGI 467

Query: 464 TSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFF-PESLGMTLPETLEQM 522
             T  R+G+++ P  +       +LP ++ G +++   ++ LFF PE+ G+ LP+T++ +
Sbjct: 468 LHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDL 527

Query: 523 QKVK 526
           +  K
Sbjct: 528 ESQK 531


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  180 bits (457), Expect = 3e-45
 Identities = 140/546 (25%), Positives = 235/546 (43%), Gaps = 64/546 (11%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63
           +++++  +G  G FQ++   L+   ++    +     F A  P H CR P  ANLS   +
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59

Query: 64  NNSVPLRL-RDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
           N  + + L RD +  P SC R+           G E       G    E C DGW +   
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114

Query: 123 VYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTG 182
            + ST+VTEW+LVC       L  SL+ VGVLLG+ V G L+DR GR+ VL         
Sbjct: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAV 174

Query: 183 FSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVG 242
                 F+ ++ ++    ++ GM      +    L  E +    R    TL +   +++G
Sbjct: 175 SGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLG 233

Query: 243 YMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAK 302
             LL   AY +  WR L L ++ P        WF  ES RW  S  R       +Q+ A+
Sbjct: 234 QFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293

Query: 303 MNNIAVPA------VIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGY 356
           +N            V+  S+++   + + +A  ++L R   +  + +   +LW  TS  Y
Sbjct: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAY 353

Query: 357 FALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQ 416
           + L +D        YL   +   +++PA +  +L++ +L RR    A L   G  +L   
Sbjct: 354 YGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

Query: 417 LVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 476
           ++P D   +   L +LGK  + ++F+ ++++T ELYPT++R                   
Sbjct: 414 VIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR------------------- 454

Query: 477 YFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRD 536
                                     +T+  PE+LG  LP+T++ ++     R GK+TR 
Sbjct: 455 -------------------------AVTVLLPETLGQPLPDTVQDLES----RKGKQTRQ 485

Query: 537 SMETEE 542
             E ++
Sbjct: 486 QQEHQK 491


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  177 bits (450), Expect = 2e-44
 Identities = 141/556 (25%), Positives = 237/556 (42%), Gaps = 71/556 (12%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63
           +++++  +G  G FQ++   L+   ++    +     F A  P H CR P  ANLS   +
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS---K 59

Query: 64  NNSVPLRL-RDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
           N  + + L RD +  P SC R+           G E       G    E C DGW +   
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNS 114

Query: 123 VYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTG 182
            + ST+VTEW+LVC       L  SL+ VGVLLG+ V G L+DR GR+ VL         
Sbjct: 115 TFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAV 174

Query: 183 FSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVG 242
                 F+ ++ ++    ++ GM      +    L  E +    R    TL +   +++G
Sbjct: 175 SGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLG 233

Query: 243 YMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAK 302
             LL   AY +  WR L L ++ P        WF  ES RW  S  R       +Q+ A+
Sbjct: 234 QFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVAR 293

Query: 303 MNNIAVPA------VIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGY 356
           +N            V+  S+++   + + +A  ++L R   +  + +   +LW  TS  Y
Sbjct: 294 INGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAY 353

Query: 357 FALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQ 416
           + L +D        YL   +   +++PA +  +L++ +L RR    A L   G  +L   
Sbjct: 354 YGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

Query: 417 LVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 476
           ++P D   +   L +LGK  + ++F+ ++++T ELYPT++R                   
Sbjct: 414 VIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR------------------- 454

Query: 477 YFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWF-------- 528
                                     +T+  PE+LG  LP+T++ ++  +W         
Sbjct: 455 -------------------------AVTVLLPETLGQPLPDTVQDLES-RWAPTQKEAGI 488

Query: 529 --RSGKKTRDSMETEE 542
             R GK+TR   E ++
Sbjct: 489 YPRKGKQTRQQQEHQK 504


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  177 bits (448), Expect = 3e-44
 Identities = 150/560 (26%), Positives = 251/560 (44%), Gaps = 33/560 (5%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP---------- 53
           +D ++  +G  G FQ  +      + I    N +   F A TP HRC VP          
Sbjct: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDN 62

Query: 54  DAANLSSA-WRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES 112
           D   LS       S+PL   D    P  C R+       +  L L  G   +  + + E 
Sbjct: 63  DTGTLSKDDLLRISIPL---DSNLRPQKCQRF---IHPQWQLLHLN-GTFPNTNEPDTEP 115

Query: 113 CLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRK-- 170
           C+DGW + +  +LST+VTEW+LVCE      +  SLF  G LLG  + G LSDR GRK  
Sbjct: 116 CVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKII 175

Query: 171 -NVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRII 229
             + F  +A+    +    F+ ++ ++ +L  + G   ++     FIL  E      R +
Sbjct: 176 CKLCFLQLAISNTCA---AFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSM 232

Query: 230 FSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRR 289
              + +C++ +VG MLL   A+ I+DW +L L ++ P ++     W + ES RWLI   +
Sbjct: 233 TIMVLLCSY-SVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQ 291

Query: 290 FREAEDIIQKAAKMNN-------IAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMT 342
             E    +++ A +N        +    V     +EL+ ++  K  I  LFR   + +  
Sbjct: 292 LDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRI-KTSIFSLFRAPKLRMRV 350

Query: 343 IMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIA 402
                +    +V ++ L L+  +L  +  L   L   +   A   + L L  + RR    
Sbjct: 351 FGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQI 410

Query: 403 AVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVG 462
              F  G  +L    +P +   L + L  LG   +++A +   V   EL PT++R+   G
Sbjct: 411 LFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAG 470

Query: 463 VTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQM 522
           + + + R G+ +AP  + L AY+  LP+I  G   +L   + L  PE+  + LP T++ +
Sbjct: 471 INAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDV 530

Query: 523 QKVKWFRSGKKTRDSMETEE 542
           +  K  R+ K+    M+  +
Sbjct: 531 ENEKDSRNIKQEDTCMKVTQ 550


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  173 bits (438), Expect = 4e-43
 Identities = 137/543 (25%), Positives = 245/543 (45%), Gaps = 31/543 (5%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63
           ++E+++ +G  G FQ L    +  S++    + +   F A  P HRC V    N + +  
Sbjct: 3   FEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGSGN 62

Query: 64  NN-----------SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES 112
                        S+PL   D    P  C R+       +  L L  G      + + E 
Sbjct: 63  ETGILSEDALLRISIPL---DSNLRPEKCRRF---VHPQWQLLHLN-GTIHSTSEADTEP 115

Query: 113 CLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNV 172
           C+DGW + Q  + ST+VT+W+LVC+      +   L   G+L+G  + G +SDRFGR+ +
Sbjct: 116 CVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFI 175

Query: 173 LFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQ---ISNYVVAFILGTEILGKSVRII 229
           L   +           F+ ++ ++ VL  + G      ISN  +          K++ +I
Sbjct: 176 LRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVI 235

Query: 230 FSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRR 289
            S+  +    ++G ++L   AY  RDW+ L +  +VP  +   L  ++ ES RWLI   +
Sbjct: 236 LSSGAL----SIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNK 291

Query: 290 FREAEDIIQKAAKMNNIAVPA------VIFDSVEELNPLKQQKAFILDLFRTRNIAIMTI 343
             E    ++K A+ N I          V+  +++E     Q K  + DLFR  ++     
Sbjct: 292 LDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRIC 351

Query: 344 MSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAA 403
           + + L    ++ ++   ++  ++  + +L   L   + +     A L L  + RR     
Sbjct: 352 ILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQIL 411

Query: 404 VLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGV 463
            +F  G  +L    VP +   L + L  LG     + FS + V   EL PT++R  A G+
Sbjct: 412 FMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGI 471

Query: 464 TSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523
             TASR+G+ +AP  + L  +   LP+I+ G   ++ G++    PE+  + LP+T++ ++
Sbjct: 472 DLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE 531

Query: 524 KVK 526
             K
Sbjct: 532 NQK 534


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  166 bits (420), Expect = 5e-41
 Identities = 120/455 (26%), Positives = 223/455 (49%), Gaps = 30/455 (6%)

Query: 103 VDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQ 162
           +  G  + ++C DGW +  D    +++ E++LVC    K      +F  G+ +GS +   
Sbjct: 145 IQFGLNDTDTCQDGWIYP-DAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRL 203

Query: 163 LSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQ-ISNYVVAFI-LGTE 220
           ++D+ GR   +  ++     F F   F  S+ ++  LF   G+ Q +  Y ++ I L TE
Sbjct: 204 ITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLY--LFFRFGISQSVVGYAISSISLATE 261

Query: 221 ILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLW---WFI 277
            L    R     LG C FFAVG +LL   AY +  W++L L   V G+L +P     W +
Sbjct: 262 WLVGEHRAHAIILGHC-FFAVGAVLLTGIAYSLPHWQLLFL---VGGILVIPFISYIWIL 317

Query: 278 PESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRN 337
           PESPRWL+ + + +EA+ ++  AA +N   +P+ + D + +L   K  +A +LD  + R 
Sbjct: 318 PESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDEL-QLPRKKVTRASVLDFCKNRQ 376

Query: 338 IAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPR 397
           +  +T++   +W   S  YF LSL    L    +    + +++E+PA +    LL+ + R
Sbjct: 377 LCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGR 436

Query: 398 RYIIAAVLFWGGGVLLFIQLVP---------------VDYYFLSIGLVMLGKFGITSAFS 442
           ++ +A  L       L +  +P                +   ++I ++ML +F + +  +
Sbjct: 437 KWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVT 496

Query: 443 MLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGI 502
           + +++TAEL PT++R   +G+ S AS  G+I++     +     +LP  +   L ++   
Sbjct: 497 VFFLYTAELLPTVLRATGLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFS 554

Query: 503 LTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDS 537
           L+   PE+    L E+L    +++      KT+++
Sbjct: 555 LSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKET 589


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  158 bits (400), Expect = 1e-38
 Identities = 147/569 (25%), Positives = 248/569 (43%), Gaps = 39/569 (6%)

Query: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP---------- 53
           + +++   G+   FQ L    LS   +    + M   F A  P HRC V           
Sbjct: 3   FQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDN 62

Query: 54  DAANLSS-AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES 112
           D   LS  A    S+PL   D    P  C R+       +  L L  G   +    + E 
Sbjct: 63  DTGALSQDALLRISIPL---DSNMRPEKCRRF---VHPQWQLLHLN-GTFPNTSDADMEP 115

Query: 113 CLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNV 172
           C+DGW + +  + ST+VTEW+LVC+      +   +F  G+++G  + G LSDRFGR+ V
Sbjct: 116 CVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFV 175

Query: 173 L---FATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRII 229
           L   +  +A+    + L    + +     L  I  M  I+N +   +L  E      + +
Sbjct: 176 LRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTI---MLIAEWATHRFQAM 232

Query: 230 FSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRR 289
             TLG+C    + +M L   A+ IRDW +L L ++VP  +      ++ ES RWLI   +
Sbjct: 233 GITLGMCP-SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNK 291

Query: 290 FREAEDIIQKAAKMNNI-----AVPAVIFDSV--EELNPLKQQKAFILDLFRTRNIAIMT 342
             E    ++KAA  + +      +   I  S   +EL   +++K  + ++    NI    
Sbjct: 292 PEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRI 351

Query: 343 IMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIA 402
            +         + YF L+L   +L  + +L   L   + + A   A   L+ + RR    
Sbjct: 352 SLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQM 411

Query: 403 AVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVG 462
            ++F     LL I  VP +   L   L  LG      A ++ +    E+ PT++R  A+G
Sbjct: 412 LLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMG 471

Query: 463 VTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQM 522
           + +T + +   +AP  + L  Y+  LP+I+ G    + G   L  PE+    L +T++  
Sbjct: 472 INATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDE 531

Query: 523 QKVKWFRSGKKTRDSMETEENPKVLITAF 551
           +  +     K  R+    +E+P+V +T F
Sbjct: 532 KNER-----KDPRE--PKQEDPRVEVTQF 553


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  155 bits (393), Expect = 7e-38
 Identities = 94/291 (32%), Positives = 153/291 (52%), Gaps = 6/291 (2%)

Query: 239 FAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQ 298
           F+ G+ L    AY +RDW +L L ++VP  LC    W++ ES RWL++  R       + 
Sbjct: 20  FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 79

Query: 299 KAAKMN------NIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLT 352
           + A +N      +   P V+  ++ E   + Q  A +  L R   +   T +S L W   
Sbjct: 80  RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 139

Query: 353 SVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVL 412
              +F L+LD   L  + +L      +++IPA + A LLL  L RR  +AA L   G  +
Sbjct: 140 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 199

Query: 413 LFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGS 472
           L   LVP +   L   L +LG  G+ +AF+ + ++++EL+PT++R  AVG+   A+R G+
Sbjct: 200 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 259

Query: 473 IIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523
           I+ P    LG +   LP +V G++ VL G+  L  PE+  + LP+T++ +Q
Sbjct: 260 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQ 310


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  151 bits (382), Expect = 1e-36
 Identities = 136/538 (25%), Positives = 236/538 (43%), Gaps = 27/538 (5%)

Query: 4   YDEVIAFLGEWGPFQRL-IFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP--------- 53
           + +++  +G  G FQ L + FL+  ++I      +   F A   +HRC V          
Sbjct: 3   FQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLEN-FAAFILDHRCWVHILDNDTIPD 61

Query: 54  -DAANLSS-AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQE 111
            D   LS  A    S+P    D    P  C R+           G  P    +  + + E
Sbjct: 62  NDPGTLSQDALLRISIPF---DSNLRPEKCRRFVHPQWKLIHLNGTFP----NTSEPDTE 114

Query: 112 SCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKN 171
            C+DGW + Q  + ST+VT+W+LVCE      +   LF  G+++G  + G LSDRFGRK 
Sbjct: 115 PCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKF 174

Query: 172 VLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFS 231
           VL  +            F+ +  ++  L  + G    S  V   +L  E +      +  
Sbjct: 175 VLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMAL 234

Query: 232 TLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFR 291
           TL +C   ++G++ L   A+ IRD  +L L ++ P  +      ++ ES RWLI   +  
Sbjct: 235 TLTLCA-ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPE 293

Query: 292 EAEDIIQKAAKMN------NIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMS 345
           E    ++KAA  N      +I    V+  ++++     Q+K  + +L R  NI       
Sbjct: 294 EGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFL 353

Query: 346 LLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVL 405
             +   +++ ++ L+L   +L  + +L   L   + + A   A   L  + RR     ++
Sbjct: 354 SFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLM 413

Query: 406 FWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTS 465
           F     LL I  VP +   L + L  LG    +   +       EL P+++R  A G+T 
Sbjct: 414 FLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITG 473

Query: 466 TASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523
             + +G  +A   + L  Y+R LP+I+ G   +L G++ L  PE+    L ++++ ++
Sbjct: 474 NFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 531


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  127 bits (320), Expect = 2e-29
 Identities = 113/414 (27%), Positives = 183/414 (44%), Gaps = 25/414 (6%)

Query: 132 WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSI 191
           WNLVC D WKVPL      +G LLG  + G   DRFGR+ V  A++ + TG    +  + 
Sbjct: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178

Query: 192 SWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAY 251
           S+    VL ++ G       +  ++   E+     R+ FS +G   F  VG +LLP  A 
Sbjct: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGLAA 237

Query: 252 FIRDWRMLL-LALTVPGVLCVPLWWF---IPESPRWLISQRRFREAEDIIQKAAKMNNI- 306
            ++DWR+L  L   + G+L +  W F    PESP WL++  +   A  I+ + A+ + + 
Sbjct: 238 LVQDWRLLQGLGALMSGLLLL-FWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 296

Query: 307 ----AVPAVIFDSVEELNPLKQQKA-----FILDLFRT----RNIAIMTIMSLLLWMLTS 353
               ++      +  EL  L  +         L L RT    RN  I+   SL+   + +
Sbjct: 297 PGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA 356

Query: 354 VGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRR-YIIAAVLFWGGGVL 412
               +L+   P      YL  FL A +E  A +   L      RR  ++   +  G   L
Sbjct: 357 SFRRSLAPQVPTF----YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASL 412

Query: 413 LFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGS 472
           L +        +  + L +LG     +  ++  +F AE++PT++R   +G+   A  +G 
Sbjct: 413 LLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQ 472

Query: 473 IIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVK 526
              P     G     L  +V  SL VL  +  L  PES    LP++L+   +++
Sbjct: 473 AAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 526


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  124 bits (310), Expect = 3e-28
 Identities = 112/414 (27%), Positives = 182/414 (43%), Gaps = 25/414 (6%)

Query: 132 WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSI 191
           WNLVC D WKVPL      +G LLG  + G   DRFGR+ V  A++ + TG    +  + 
Sbjct: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180

Query: 192 SWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAY 251
           S+    VL ++ G       +  ++   E+     R+ FS +G   F  VG +LLP  A 
Sbjct: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGLAA 239

Query: 252 FIRDWRMLL-LALTVPGVLCVPLWWF---IPESPRWLISQRRFREAEDIIQKAAKMNNI- 306
            ++DWR+L  L   + G+L +  W F    PESP WL++  +   A  I+ + A+ + + 
Sbjct: 240 LVQDWRLLQGLGALMSGLLLL-FWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 298

Query: 307 ----AVPAVIFDSVEELNPLKQQKA-----FILDLFRT----RNIAIMTIMSLLLWMLTS 353
               ++      +  EL  L  +         L L RT    RN  I+   SL+   + +
Sbjct: 299 PGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA 358

Query: 354 VGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRR-YIIAAVLFWGGGVL 412
               +L+   P      YL  FL A +E  A +   L      RR  ++   +  G   L
Sbjct: 359 SFRRSLAPQVPTF----YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASL 414

Query: 413 LFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGS 472
           L +        +  + L +LG     +  ++  +F AE++PT++R   +G+   A  +G 
Sbjct: 415 LLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQ 474

Query: 473 IIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVK 526
                    G     L  +V  SL VL  +  L  PES    LP++L+   +++
Sbjct: 475 AAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 528


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  120 bits (300), Expect = 4e-27
 Identities = 137/568 (24%), Positives = 231/568 (40%), Gaps = 67/568 (11%)

Query: 3   DYD-EVIAFLGEWGP-FQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP----DAA 56
           DYD  V+ FLG  G  +Q+ +  L     +  GF+  S  FL   P   CR      + A
Sbjct: 79  DYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELA 138

Query: 57  NLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDV-------DLGQLE 109
            +++  R   +          P + + +  A   N S      G D        D G   
Sbjct: 139 GVTTTGRGGDMG-NWTSLPTTPFATAPWEAA--GNRSNSSGADGGDTPPLPSPPDKGDNA 195

Query: 110 QESCLDGWEFSQDVYL-STVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFG 168
                  W++     L   VV++W+LVC++ WKV +      VG++ G  ++G ++D  G
Sbjct: 196 SNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVG 255

Query: 169 RKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRI 228
           R+ VL  ++     F      S++  MF+ L    G       +  + L  E+     R 
Sbjct: 256 RRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRF 315

Query: 229 IFSTLGVCTFFAV-GYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQ 287
           + +   V +F A+ G  L+P  A   RDW++L   +  P +L +  W   PES RWL++ 
Sbjct: 316 MITM--VASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMAT 373

Query: 288 RRFREAEDIIQKAAKMNNIAVPAVIFDSVEELN---PLKQQKAFILDLFRTRNIAIMTIM 344
           ++F  A+ +I    + N +     I   + EL      + +K  I+ +  TRN+    I+
Sbjct: 374 QQFESAKRLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNL-WKNIV 432

Query: 345 SLLLWMLTSVGY---FALSLDAPN----LHGDAYLNCFLSALIEIPAYITAWLLLRTLPR 397
            L +  LT  G    FA S+        L  + Y + + +A I + + +   +++R L R
Sbjct: 433 VLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGR 492

Query: 398 RYIIAAVLFWGGGVLLFIQLVPVDYYF--------------------------LSIGLVM 431
           R          GG+LLF+ L  +                               SI   +
Sbjct: 493 R----------GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSI 542

Query: 432 LGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYI 491
           +G F   +  S+   F AE+ PT++R   +G+   ++  G + AP           L +I
Sbjct: 543 VGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHI 602

Query: 492 VMGSLTVLIGILTLFFPESLGMTLPETL 519
           +    T++  I  L  PES    LPE +
Sbjct: 603 IFACCTLICIICILLLPESRDQNLPENI 630


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  118 bits (296), Expect = 1e-26
 Identities = 100/432 (23%), Positives = 193/432 (44%), Gaps = 53/432 (12%)

Query: 131 EWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFS 190
           EW L   +NW+V L T++ F G ++ S + G L+DR+GR  +L  +      FS L  F+
Sbjct: 78  EWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134

Query: 191 ISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFA 250
            S+  F  L  +VG G +S +    I+ TE L    R     L    + A   +++ L +
Sbjct: 135 PSYIWFVFLRTMVGCG-VSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193

Query: 251 YFIR--DWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAV 308
             I    WR L+   ++PG++ +  + FIPES R+ +S    R A   +++ AKMN   +
Sbjct: 194 VIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVM 253

Query: 309 PAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNL-- 366
           P       + + P+ +++    DL   + +   T+   ++W+  S  Y+ + L +  L  
Sbjct: 254 P-----EGKLVEPVLEKRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLE 307

Query: 367 ----------------HGDA----------------YLNCFLSALIEIPAYITAWLLLRT 394
                            GD+                Y    +S + EI       L +  
Sbjct: 308 RDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINF 367

Query: 395 LPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPT 454
           L RR  ++  +  G   L F+ L         IG + + +  + + F+ +Y++TAE+YPT
Sbjct: 368 LGRRLSLSITM--GCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPT 425

Query: 455 LVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMT 514
            +R + +G + +  R+G+++AP+   +     ++   ++G+L +   +  +    +  + 
Sbjct: 426 TMRALGMGTSGSLCRIGAMVAPFISQV-----LMSASILGALCLFSSVCVVCAISAFTLP 480

Query: 515 LPETLEQMQKVK 526
           +      +Q++K
Sbjct: 481 IETKGRALQQIK 492


>gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo
           sapiens]
          Length = 495

 Score =  111 bits (277), Expect = 2e-24
 Identities = 106/402 (26%), Positives = 167/402 (41%), Gaps = 64/402 (15%)

Query: 132 WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSI 191
           WNLVC D WKVPL      +G LLG  + G   DRFGR+ V  A++ + TG    +  + 
Sbjct: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178

Query: 192 SWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAY 251
           S+    VL ++ G       +  ++   E+     R+ FS +G   F  VG +LLP  A 
Sbjct: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGLAA 237

Query: 252 FIRDWRMLL-LALTVPGVLCVPLWWF---IPESPRWLISQRRFREAEDIIQKAAKMNNIA 307
            ++DWR+L  L   + G+L +  W F    PESP WL++  +   A  I+ + A+ + + 
Sbjct: 238 LVQDWRLLQGLGALMSGLLLL-FWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 296

Query: 308 VPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLH 367
                  S+EE                  ++A  T +++                     
Sbjct: 297 PGD---SSLEE-----------------NSLATATELTM--------------------- 315

Query: 368 GDAYLNCFLSALIEIPAYITAWLLLR---TLPRRYIIAAVLFWGGGVLLFIQLVPVDYYF 424
                   LSA    P Y +   LLR   T     I+      GGG+     L      F
Sbjct: 316 --------LSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIR--ANLPGWTVLF 365

Query: 425 LSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAY 484
           LS+    LG     +  ++  +F AE++PT++R   +G+   A  +G          G  
Sbjct: 366 LSV----LGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQ 421

Query: 485 NRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVK 526
              L  +V  SL VL  +  L  PES    LP++L+   +++
Sbjct: 422 GFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 463


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.142    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,797,686
Number of Sequences: 37866
Number of extensions: 791171
Number of successful extensions: 2668
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2469
Number of HSP's gapped (non-prelim): 98
length of query: 551
length of database: 18,247,518
effective HSP length: 107
effective length of query: 444
effective length of database: 14,195,856
effective search space: 6302960064
effective search space used: 6302960064
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.