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Search of human proteins with 24307971
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 946 0.0
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 824 0.0
gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens] 389 e-108
gi|4758666 LATS homolog 1 [Homo sapiens] 387 e-107
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 305 7e-83
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 303 2e-82
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 303 2e-82
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 297 1e-80
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 291 1e-78
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 285 5e-77
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 275 6e-74
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 275 6e-74
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 275 6e-74
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 275 6e-74
gi|32698688 citron [Homo sapiens] 250 2e-66
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 236 4e-62
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 233 4e-61
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 233 4e-61
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 232 6e-61
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 230 2e-60
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 229 4e-60
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 228 9e-60
gi|148727255 microtubule associated serine/threonine kinase fami... 226 3e-59
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 223 4e-58
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 221 8e-58
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 221 8e-58
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 219 4e-57
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 217 2e-56
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 217 2e-56
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 217 2e-56
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 946 bits (2446), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLAD 60
MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLAD
Sbjct: 1 MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLAD 60
Query: 61 EEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKI 120
EEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKI
Sbjct: 61 EEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKI 120
Query: 121 LRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLM 180
LRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLM
Sbjct: 121 LRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLM 180
Query: 181 KKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKK 240
KKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKK
Sbjct: 181 KKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKK 240
Query: 241 AHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGY 300
AHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGY
Sbjct: 241 AHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGY 300
Query: 301 NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR 360
NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR
Sbjct: 301 NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR 360
Query: 361 FCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL 420
FCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL
Sbjct: 361 FCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL 420
Query: 421 QPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL 464
QPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL
Sbjct: 421 QPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL 464
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 824 bits (2128), Expect = 0.0
Identities = 405/466 (86%), Positives = 430/466 (92%), Gaps = 4/466 (0%)
Query: 1 MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLAD 60
MAMT G+T MSNHT+ERVT+ K+TLENFYSNLI QHEERE RQKKLE MEEEGL D
Sbjct: 1 MAMT-GSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKD 59
Query: 61 EEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKI 120
EEK+LRRS HARKETEFLRLKRTRLGL+DFESLKVIGRGAFGEVRLVQKKDTGH+YAMKI
Sbjct: 60 EEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKI 119
Query: 121 LRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLM 180
LRK+DMLEKEQV HIRAERDILVEAD WVVKMFYSFQDK NLYLIMEFLPGGDMMTLLM
Sbjct: 120 LRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLM 179
Query: 181 KKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKK 240
KKDTLTEEETQFYI+ETVLAID+IHQLGFIHRDIKPDNLLLD+KGHVKLSDFGLCTGLKK
Sbjct: 180 KKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKK 239
Query: 241 AHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGY 300
AHRTEFYRNL H+ PSDF+FQNMNSKRKAETWK+NRRQLA+STVGTPDYIAPEVFMQTGY
Sbjct: 240 AHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGY 299
Query: 301 NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR 360
NKLCDWWSLGVIMYEMLIGYPPFCSETPQETY+KVMNWKETL FPPEVPISEKAKDLILR
Sbjct: 300 NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILR 359
Query: 361 FCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL 420
FC + E+RIG GVEEIK + FFEGVDWEHIRERPAAI IEIKSIDDTSNFD+FPESDIL
Sbjct: 360 FCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDIL 419
Query: 421 QP---VPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGK 463
+P N E DYK+KDWVF+NYTYKRFEGLT RG+IP+YMKA K
Sbjct: 420 KPTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK 465
>gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]
Length = 1088
Score = 389 bits (998), Expect = e-108
Identities = 194/443 (43%), Positives = 286/443 (64%), Gaps = 21/443 (4%)
Query: 25 KLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTR 84
K +E N+I ++++ R+ +LE M + GL + E++ R +KE+ + RLKR +
Sbjct: 603 KFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAK 662
Query: 85 LGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE 144
+ F +K +G GAFGEV L K DT +YAMK LRK D+L + QVAH++AERDIL E
Sbjct: 663 MDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAE 722
Query: 145 ADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAI 204
AD WVVK++YSFQDK +LY +M+++PGGDMM+LL++ + E +FYI+E LAI+++
Sbjct: 723 ADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESV 782
Query: 205 HQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTH-----NPPSDF- 258
H++GFIHRDIKPDN+L+D GH+KL+DFGLCTG + H +++Y+ +H PSD
Sbjct: 783 HKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLW 842
Query: 259 -SFQNMNSKRKAETW-----KKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 312
N + +T K+++R LA+S VGTP+YIAPEV ++ GY +LCDWWS+GVI
Sbjct: 843 DDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVI 902
Query: 313 MYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNS 372
++EML+G PPF + TP ET KV+NW+ TL P +V +S +A+DLI + C +++R+G +
Sbjct: 903 LFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRN 962
Query: 373 GVEEIKGHPFFEGVDW-EHIRERPAAIPIEIKSIDDTSNFDDFPESD--------ILQPV 423
G +++K HPFF +D+ IR++PA I DTSNFD E +
Sbjct: 963 GADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAW 1022
Query: 424 PNTTEPDYKSKDWVFLNYTYKRF 446
T P+ K + F +T++RF
Sbjct: 1023 DTLTSPNNKHPEHAFYEFTFRRF 1045
>gi|4758666 LATS homolog 1 [Homo sapiens]
Length = 1130
Score = 387 bits (994), Expect = e-107
Identities = 192/444 (43%), Positives = 287/444 (64%), Gaps = 22/444 (4%)
Query: 25 KLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTR 84
K +E N++ H++R R+K+LE M GL+ + + R +KE+ ++RLKR +
Sbjct: 640 KFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAK 699
Query: 85 LGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE 144
+ F +K +G GAFGEV L +K DT +YA K LRK D+L + QVAH++AERDIL E
Sbjct: 700 MDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAE 759
Query: 145 ADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAI 204
AD WVV+++YSFQDK NLY +M+++PGGDMM+LL++ E +FYI+E A++++
Sbjct: 760 ADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESV 819
Query: 205 HQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQN-- 262
H++GFIHRDIKPDN+L+D GH+KL+DFGLCTG + H +++Y++ H F N
Sbjct: 820 HKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEW 879
Query: 263 --MNSKRKAETWK--------KNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 312
+S R + K +++R LA+S VGTP+YIAPEV ++TGY +LCDWWS+GVI
Sbjct: 880 GDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVI 939
Query: 313 MYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNS 372
++EML+G PPF ++TP ET KV+NW+ +L PP+ +S +A DLI++ C E+R+G +
Sbjct: 940 LFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKN 999
Query: 373 GVEEIKGHPFFEGVDW-EHIRERPAAIPIEIKSIDDTSNFD---------DFPESDILQP 422
G +EIK HPFF+ +D+ +R++ A+ +I DTSNFD D E + +
Sbjct: 1000 GADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVND 1059
Query: 423 VPNTTEPDYKSKDWVFLNYTYKRF 446
N + K + F +T++RF
Sbjct: 1060 TLNGWYKNGKHPEHAFYEFTFRRF 1083
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 305 bits (780), Expect = 7e-83
Identities = 173/415 (41%), Positives = 244/415 (58%), Gaps = 51/415 (12%)
Query: 65 LRRSQHARKETEFLR-----LKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMK 119
LRR ++ + E+ + +K +L +DFE +KVIGRGAFGEV +V+ K+T IYAMK
Sbjct: 46 LRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMK 105
Query: 120 ILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLL 179
IL K +ML++ + A R ERD+LV D W+ + Y+FQD+ +LYL+M++ GGD++TLL
Sbjct: 106 ILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLL 165
Query: 180 MK-KDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGL 238
K +D L E+ +FYI E VLAID+IHQL ++HRDIKPDN+LLD GH++L+DFG C
Sbjct: 166 SKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCL-- 223
Query: 239 KKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVF--M 296
MN + + VGTPDYI+PE+ M
Sbjct: 224 -----------------------KMNDDGTVQ---------SSVAVGTPDYISPEILQAM 251
Query: 297 QTG---YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEV-PISE 352
+ G Y CDWWSLGV MYEML G PF +E+ ETY K+MN +E FP V +SE
Sbjct: 252 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSE 311
Query: 353 KAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
+AKDLI R E R+G +G+E+ K H FFEG++WE+IR A ++ S DTSNFD
Sbjct: 312 EAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFD 371
Query: 413 DFPESDIL---QPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL 464
+ D+L + +P + + F+ +T+ + RGS+ + M++ L
Sbjct: 372 --VDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTL 424
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 303 bits (777), Expect = 2e-82
Identities = 165/375 (44%), Positives = 228/375 (60%), Gaps = 46/375 (12%)
Query: 79 RLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAE 138
++K+ RL +DFE LKVIGRGAFGEV +V+ K+ ++AMKIL K +ML++ + A R E
Sbjct: 66 KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125
Query: 139 RDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISET 197
RD+LV D W+ + Y+FQD NLYL+M++ GGD++TLL K +D L E+ +FY++E
Sbjct: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
Query: 198 VLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSD 257
V+AID++HQL ++HRDIKPDN+L+D GH++L+DFG C L + D
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLME----------------D 229
Query: 258 FSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 312
+ Q+ VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 230 GTVQSS------------------VAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC 271
Query: 313 MYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEV-PISEKAKDLILRFCIDSENRIGN 371
MYEML G PF +E+ ETY K+MN KE FP +V +SE AKDLI R E+R+G
Sbjct: 272 MYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQ 331
Query: 372 SGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL---QPVPNTTE 428
+G+E+ K HPFF G+DW++IR A E+ S DTSNFD + D L + +P T
Sbjct: 332 NGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD--VDDDCLKNSETMPPPTH 389
Query: 429 PDYKSKDWVFLNYTY 443
+ F+ +TY
Sbjct: 390 TAFSGHHLPFVGFTY 404
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 303 bits (777), Expect = 2e-82
Identities = 165/375 (44%), Positives = 228/375 (60%), Gaps = 46/375 (12%)
Query: 79 RLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAE 138
++K+ RL +DFE LKVIGRGAFGEV +V+ K+ ++AMKIL K +ML++ + A R E
Sbjct: 66 KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125
Query: 139 RDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISET 197
RD+LV D W+ + Y+FQD NLYL+M++ GGD++TLL K +D L E+ +FY++E
Sbjct: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
Query: 198 VLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSD 257
V+AID++HQL ++HRDIKPDN+L+D GH++L+DFG C L + D
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLME----------------D 229
Query: 258 FSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 312
+ Q+ VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 230 GTVQSS------------------VAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC 271
Query: 313 MYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEV-PISEKAKDLILRFCIDSENRIGN 371
MYEML G PF +E+ ETY K+MN KE FP +V +SE AKDLI R E+R+G
Sbjct: 272 MYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQ 331
Query: 372 SGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL---QPVPNTTE 428
+G+E+ K HPFF G+DW++IR A E+ S DTSNFD + D L + +P T
Sbjct: 332 NGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD--VDDDCLKNSETMPPPTH 389
Query: 429 PDYKSKDWVFLNYTY 443
+ F+ +TY
Sbjct: 390 TAFSGHHLPFVGFTY 404
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 297 bits (761), Expect = 1e-80
Identities = 162/375 (43%), Positives = 224/375 (59%), Gaps = 46/375 (12%)
Query: 79 RLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAE 138
++K RL DDFE LKVIGRGAFGEV +V+++DTG I+AMK+L K +ML++ + A R E
Sbjct: 60 KVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREE 119
Query: 139 RDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISET 197
RD+LV+ D WV + Y+FQD+ LYL+M++ GGD++TLL + +D L E QFY++E
Sbjct: 120 RDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEM 179
Query: 198 VLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSD 257
VLAI ++HQLG++HRD+KPDN+LLD GH++L+DFG C L N D
Sbjct: 180 VLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCL------------RLNTNGMVD 227
Query: 258 FSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 312
S VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 228 SSV----------------------AVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVC 265
Query: 313 MYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVP-ISEKAKDLILRFCIDSENRIGN 371
YE+L G PF +E+ ETY K+MN ++ L FPP+VP + A+DLI + E R+G
Sbjct: 266 AYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGR 325
Query: 372 SGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQ---PVPNTTE 428
G+++ + HPFFEGVDWE + A E++ DTSNFD + D L +P +
Sbjct: 326 GGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFD--VDDDTLNHPGTLPPPSH 383
Query: 429 PDYKSKDWVFLNYTY 443
+ F+ +TY
Sbjct: 384 GAFSGHHLPFVGFTY 398
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 291 bits (744), Expect = 1e-78
Identities = 156/374 (41%), Positives = 222/374 (59%), Gaps = 48/374 (12%)
Query: 79 RLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAE 138
+++ R+ +D+E +KVIGRGAFGEV+LV+ K T +YAMK+L K +M+++ A E
Sbjct: 65 KIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEE 124
Query: 139 RDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETV 198
RDI+ A+ WVV++FY+FQD R LY++ME++PGGD++ L+ D + E+ +FY +E V
Sbjct: 125 RDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVV 183
Query: 199 LAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDF 258
LA+DAIH +GFIHRD+KPDN+LLD GH+KL+DFG C + K
Sbjct: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVR------------- 230
Query: 259 SFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG----YNKLCDWWSLGVIMY 314
+ VGTPDYI+PEV G Y + CDWWS+GV +Y
Sbjct: 231 ---------------------CDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLY 269
Query: 315 EMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGV 374
EML+G PF +++ TY K+MN K +L FP + IS++AK+LI F D E R+G +GV
Sbjct: 270 EMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGV 329
Query: 375 EEIKGHPFFEGVD--WEHIRERPAAIPIEIKSIDDTSNFDDFPE---SDILQPVPNTTEP 429
EEIK H FF+ WE +R+ A + ++ S DTSNFDD E + P+P
Sbjct: 330 EEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKA--- 386
Query: 430 DYKSKDWVFLNYTY 443
+ F+ +TY
Sbjct: 387 -FVGNQLPFVGFTY 399
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 285 bits (730), Expect = 5e-77
Identities = 155/383 (40%), Positives = 228/383 (59%), Gaps = 48/383 (12%)
Query: 72 RKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQ 131
R E +++ ++ +D++ +KVIGRGAFGEV+LV+ K + +YAMK+L K +M+++
Sbjct: 74 RYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSD 133
Query: 132 VAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQ 191
A ERDI+ A+ WVV++FY+FQD R LY++ME++PGGD++ L+ D + E+ +
Sbjct: 134 SAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAK 192
Query: 192 FYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLT 251
FY +E VLA+DAIH +G IHRD+KPDN+LLD GH+KL+DFG C + + +
Sbjct: 193 FYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDET-------GMV 245
Query: 252 HNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG----YNKLCDWW 307
H + VGTPDYI+PEV G Y + CDWW
Sbjct: 246 H---------------------------CDTAVGTPDYISPEVLKSQGGDGFYGRECDWW 278
Query: 308 SLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSEN 367
S+GV +YEML+G PF +++ TY K+M+ K +L FP + IS+ AK+LI F D E
Sbjct: 279 SVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREV 338
Query: 368 RIGNSGVEEIKGHPFFEGVD--WEHIRERPAAIPIEIKSIDDTSNFDDFPE--SDI-LQP 422
R+G +GVEEI+ HPFF+ W++IRE A + E+ S D+SNFDD + D+ P
Sbjct: 339 RLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFP 398
Query: 423 VPNTTEPDYKSKDWVFLNYTYKR 445
+P + F+ +TY R
Sbjct: 399 IPKA----FVGNQLPFIGFTYYR 417
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 275 bits (703), Expect = 6e-74
Identities = 141/344 (40%), Positives = 206/344 (59%), Gaps = 43/344 (12%)
Query: 78 LRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRA 137
+RLK RL DDFE LKVIGRGAF EV +V+ K TG +YAMKI+ K DML++ +V+ R
Sbjct: 69 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 128
Query: 138 ERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISE 196
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY++E
Sbjct: 129 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 188
Query: 197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPS 256
V+AID++H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 189 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 232
Query: 257 DFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 309
D + +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 233 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 274
Query: 310 GVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFP-PEVPISEKAKDLILRFCIDSENR 368
GV YEM G PF +++ ETY K++++KE L P + + E+A+D I R E R
Sbjct: 275 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 334
Query: 369 IGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
+G G + + HPFF G+DW+ +R+ + + DT NFD
Sbjct: 335 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 378
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 275 bits (703), Expect = 6e-74
Identities = 141/344 (40%), Positives = 206/344 (59%), Gaps = 43/344 (12%)
Query: 78 LRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRA 137
+RLK RL DDFE LKVIGRGAF EV +V+ K TG +YAMKI+ K DML++ +V+ R
Sbjct: 59 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
Query: 138 ERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISE 196
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY++E
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
Query: 197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPS 256
V+AID++H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
Query: 257 DFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 309
D + +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
Query: 310 GVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFP-PEVPISEKAKDLILRFCIDSENR 368
GV YEM G PF +++ ETY K++++KE L P + + E+A+D I R E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
Query: 369 IGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
+G G + + HPFF G+DW+ +R+ + + DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 275 bits (703), Expect = 6e-74
Identities = 141/344 (40%), Positives = 206/344 (59%), Gaps = 43/344 (12%)
Query: 78 LRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRA 137
+RLK RL DDFE LKVIGRGAF EV +V+ K TG +YAMKI+ K DML++ +V+ R
Sbjct: 59 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
Query: 138 ERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISE 196
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY++E
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
Query: 197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPS 256
V+AID++H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
Query: 257 DFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 309
D + +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
Query: 310 GVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFP-PEVPISEKAKDLILRFCIDSENR 368
GV YEM G PF +++ ETY K++++KE L P + + E+A+D I R E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
Query: 369 IGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
+G G + + HPFF G+DW+ +R+ + + DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 275 bits (703), Expect = 6e-74
Identities = 141/344 (40%), Positives = 206/344 (59%), Gaps = 43/344 (12%)
Query: 78 LRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRA 137
+RLK RL DDFE LKVIGRGAF EV +V+ K TG +YAMKI+ K DML++ +V+ R
Sbjct: 59 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
Query: 138 ERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISE 196
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY++E
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
Query: 197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPS 256
V+AID++H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
Query: 257 DFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 309
D + +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
Query: 310 GVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFP-PEVPISEKAKDLILRFCIDSENR 368
GV YEM G PF +++ ETY K++++KE L P + + E+A+D I R E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
Query: 369 IGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
+G G + + HPFF G+DW+ +R+ + + DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 250 bits (638), Expect = 2e-66
Identities = 141/394 (35%), Positives = 215/394 (54%), Gaps = 46/394 (11%)
Query: 68 SQHARKETEFL-RLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDM 126
S RK ++ + L+ + DFE ++G G F EV++V++K TG IYAMK+++K +
Sbjct: 74 SNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKAL 133
Query: 127 LEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTL 185
L +EQV+ ER+IL + W+ ++ Y+FQDK +LYL+ME+ PGGD+++LL + +D L
Sbjct: 134 LAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQL 193
Query: 186 TEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTE 245
E QFY++E +LA+ ++H +G++HRDIKP+N+L+D GH+KL DFG
Sbjct: 194 DENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFG------------ 241
Query: 246 FYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFM------QTG 299
S MNS N+ A +GTPDY+APEV +
Sbjct: 242 -------------SAAKMNS---------NKMVNAKLPIGTPDYMAPEVLTVMNGDGKGT 279
Query: 300 YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLIL 359
Y CDWWS+GVI YEM+ G PF T T+ +MN++ L FP + +S DLI
Sbjct: 280 YGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQ 339
Query: 360 RFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDI 419
+ R+ G + HPFF +DW +IR P +KS DDTSNFD+ ++
Sbjct: 340 SLLCGQKERLKFEG---LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSW 396
Query: 420 LQPVPNTTEPD-YKSKDWVFLNYTYKRFEGLTQR 452
+ P P + ++ F+ ++Y + G+ R
Sbjct: 397 VSSSPCQLSPSGFSGEELPFVGFSYSKALGILGR 430
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 236 bits (601), Expect = 4e-62
Identities = 138/410 (33%), Positives = 215/410 (52%), Gaps = 54/410 (13%)
Query: 22 TVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQH---ARKETEFL 78
T A LE F S L +H + +K + + ++ RS A+ + +FL
Sbjct: 16 TTALQKLEGFASRLFHRHSKGTAHDQKTALENDSLHFSEHTALWDRSMKEFLAKAKEDFL 75
Query: 79 RL----KRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAH 134
+ + GL+DFE K +G G+FG V LV+ K T YAMKIL K +++ +Q+ H
Sbjct: 76 KKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 135
Query: 135 IRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYI 194
E+ IL + ++V++ Y+F+D NLY++ME++PGG+M + L + +E +FY
Sbjct: 136 TLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 195
Query: 195 SETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNP 254
++ VL + +H L I+RD+KP+NLL+D +G+++++DFG
Sbjct: 196 AQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA------------------- 236
Query: 255 PSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMY 314
+ K TW + GTP+Y+APE+ + GYNK DWW+LGV++Y
Sbjct: 237 ----------KRVKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIY 277
Query: 315 EMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRIGN-- 371
EM GYPPF ++ P + Y K+++ K + FP S KDL+ +D R GN
Sbjct: 278 EMAAGYPPFFADQPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLK 333
Query: 372 SGVEEIKGHPFFEGVDWEHIRERPAAIPI--EIKSIDDTSNFDDFPESDI 419
+GV +IK H +F DW I +R P + + DTSNFDD+ E DI
Sbjct: 334 NGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDI 383
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 233 bits (593), Expect = 4e-61
Identities = 125/338 (36%), Positives = 191/338 (56%), Gaps = 47/338 (13%)
Query: 87 LDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEAD 146
LD FE +K +G G+FG V LV+ K+TG+ YAMKIL K +++ +Q+ H E+ IL +
Sbjct: 33 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 92
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
++VK+ +SF+D NLY++ME++PGG+M + L + +E +FY ++ VL + +H
Sbjct: 93 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 152
Query: 207 LGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSK 266
L I+RD+KP+NLL+D +G+++++DFG +
Sbjct: 153 LDLIYRDLKPENLLIDQQGYIQVTDFGFA-----------------------------KR 183
Query: 267 RKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 326
K TW + GTP+Y+APE+ + GYNK DWW+LGV++YEM GYPPF ++
Sbjct: 184 VKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 234
Query: 327 TPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRIGN--SGVEEIKGHPFF 383
P + Y K+++ K + FP S KDL+ +D R GN +GV +IK H +F
Sbjct: 235 QPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 290
Query: 384 EGVDWEHIRERPAAIPI--EIKSIDDTSNFDDFPESDI 419
DW I +R P + K DTSNFDD+ E +I
Sbjct: 291 ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 328
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 233 bits (593), Expect = 4e-61
Identities = 125/338 (36%), Positives = 191/338 (56%), Gaps = 47/338 (13%)
Query: 87 LDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEAD 146
LD FE +K +G G+FG V LV+ K+TG+ YAMKIL K +++ +Q+ H E+ IL +
Sbjct: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
++VK+ +SF+D NLY++ME++PGG+M + L + +E +FY ++ VL + +H
Sbjct: 101 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
Query: 207 LGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSK 266
L I+RD+KP+NLL+D +G+++++DFG +
Sbjct: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFA-----------------------------KR 191
Query: 267 RKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 326
K TW + GTP+Y+APE+ + GYNK DWW+LGV++YEM GYPPF ++
Sbjct: 192 VKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 242
Query: 327 TPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRIGN--SGVEEIKGHPFF 383
P + Y K+++ K + FP S KDL+ +D R GN +GV +IK H +F
Sbjct: 243 QPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298
Query: 384 EGVDWEHIRERPAAIPI--EIKSIDDTSNFDDFPESDI 419
DW I +R P + K DTSNFDD+ E +I
Sbjct: 299 ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 336
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 232 bits (591), Expect = 6e-61
Identities = 138/359 (38%), Positives = 205/359 (57%), Gaps = 46/359 (12%)
Query: 90 FESLKVIGRGAFGEVRLVQKK---DTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEAD 146
FE LKV+G+G+FG+V LV+KK D G +YAMK+L+K+ + +++V + ERDILVE +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVN 131
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
++VK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY++E LA+D +HQ
Sbjct: 132 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 191
Query: 207 LGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSK 266
LG ++RD+KP+N+LLD GH+KL+DFGL SK
Sbjct: 192 LGIVYRDLKPENILLDEIGHIKLTDFGL------------------------------SK 221
Query: 267 RKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 326
+ KK AYS GT +Y+APEV + G+++ DWWS GV+M+EML G PF +
Sbjct: 222 ESVDQEKK-----AYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGK 276
Query: 327 TPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGV 386
ET ++ K + P+ +E L + F + NR+G+ GVEEIK H FF +
Sbjct: 277 DRNETMNMILKAKLGM---PQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANI 333
Query: 387 DWEHIRERPAAIPIEIKS--IDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTY 443
DW+ + +R P + S DDT FD PE P + P + +F +++
Sbjct: 334 DWDKLYKREVQPPFKPASGKPDDTFCFD--PEFTAKTPKDSPGLPASANAHQLFKGFSF 390
Score = 100 bits (249), Expect = 3e-21
Identities = 73/277 (26%), Positives = 124/277 (44%), Gaps = 50/277 (18%)
Query: 90 FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE-ADGA 148
+E + IG G++ + T +A+KI+ KS E++ +IL+
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI-------EILMRYGQHP 478
Query: 149 WVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLG 208
++ + F D R +YL+ + + GG+++ ++K+ +E E + +D +H G
Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
Query: 209 FIHRDIKPDNLLL----DAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMN 264
+HRD+KP N+L + +++ DFG L+
Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLR------------------------- 573
Query: 265 SKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFC 324
L + T +++APEV MQ GY+ CD WSLGV+ Y ML GY PF
Sbjct: 574 ----------GENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFA 623
Query: 325 ---SETPQETYRKVMNWKETLVFPPEVPISEKAKDLI 358
++TP+E ++ N K +L IS+ AKDL+
Sbjct: 624 NGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL 660
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 230 bits (586), Expect = 2e-60
Identities = 121/326 (37%), Positives = 189/326 (57%), Gaps = 24/326 (7%)
Query: 89 DFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGA 148
DFE++K+I GA+G V LV+ +DT +A+K + K +++ + Q+ + ERDIL A+
Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
Query: 149 WVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLG 208
+VV MF SF+ +R+L ++ME++ GGD TLL L + + Y +ETVLA++ +H G
Sbjct: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYG 485
Query: 209 FIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRK 268
+HRD+KPDNLL+ + GH+KL+DFGL + T Y +
Sbjct: 486 IVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLY--------------------E 525
Query: 269 AETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 328
K R + GTP+YIAPEV + GY K DWW++GV++YE L+G PF +TP
Sbjct: 526 GHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTP 585
Query: 329 QETYRKVMNWKETLVFPP-EVPISEKAKDLILRFCIDSE-NRIGNSGVEEIKGHPFFEGV 386
+E + +V++ + +++P + + A+DLI R S +R+G G E+K HPFF +
Sbjct: 586 EELFGQVVS--DEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLAL 643
Query: 387 DWEHIRERPAAIPIEIKSIDDTSNFD 412
DW + A ++++ DDTS FD
Sbjct: 644 DWAGLLRHKAEFVPQLEAEDDTSYFD 669
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 229 bits (584), Expect = 4e-60
Identities = 127/358 (35%), Positives = 197/358 (55%), Gaps = 51/358 (14%)
Query: 71 ARKETEFLRL----KRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDM 126
A+ + +FL+ + GL+DFE K +G G+FG V LV+ K T YAMKIL K +
Sbjct: 21 AKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKV 80
Query: 127 LEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLT 186
++ +Q+ H E+ IL + ++V++ Y+F+D NLY++ME++PGG+M + L + +
Sbjct: 81 VKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140
Query: 187 EEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEF 246
E +FY ++ VL + +H L I+RD+KP+NLL+D +G+++++DFG
Sbjct: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA----------- 189
Query: 247 YRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDW 306
+ K TW + GTP+Y+APE+ + GYNK DW
Sbjct: 190 ------------------KRVKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDW 222
Query: 307 WSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDS 365
W+LGV++YEM GYPPF ++ P + Y K+++ K + FP S KDL+ +D
Sbjct: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDL 278
Query: 366 ENRIGN--SGVEEIKGHPFFEGVDWEHIRERPAAIPI--EIKSIDDTSNFDDFPESDI 419
R GN +GV +IK H +F DW I +R P + + DTSNFDD+ E DI
Sbjct: 279 TKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDI 336
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 228 bits (581), Expect = 9e-60
Identities = 123/327 (37%), Positives = 187/327 (57%), Gaps = 24/327 (7%)
Query: 88 DDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADG 147
+DFE++K+I GA+G V LV+ K T +AMK + K +++ + Q+ ERDIL A+
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
Query: 148 AWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQL 207
+VV MF SF KR+L ++ME++ GGD TLL L + + Y +ETVLA++ +H
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 629
Query: 208 GFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKR 267
G +HRD+KPDNLL+ + GH+KL+DFGL + T Y
Sbjct: 630 GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLY-------------------- 669
Query: 268 KAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 327
+ K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF +T
Sbjct: 670 EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDT 729
Query: 328 PQETYRKVMNWKETLVFPP-EVPISEKAKDLILRFCIDSE-NRIGNSGVEEIKGHPFFEG 385
P+E + +V++ + +V+P + + A+DL + + R+G E+K HPFF G
Sbjct: 730 PEELFGQVIS--DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTG 787
Query: 386 VDWEHIRERPAAIPIEIKSIDDTSNFD 412
+DW + + A +++S DDTS FD
Sbjct: 788 LDWTGLLRQKAEFIPQLESEDDTSYFD 814
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 226 bits (577), Expect = 3e-59
Identities = 129/370 (34%), Positives = 200/370 (54%), Gaps = 33/370 (8%)
Query: 89 DFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGA 148
DFE++K+I GA+G V V+ K++ +AMK + K +++ + Q+ ERDIL A+
Sbjct: 380 DFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 439
Query: 149 WVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLG 208
+VV M+ SF+ +R+L ++ME++ GGD TL+ L + + Y +ETVLA++ +H G
Sbjct: 440 FVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYG 499
Query: 209 FIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRK 268
+HRD+KPDNLL+ + GH+KL+DFGL + T Y +
Sbjct: 500 IVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLY--------------------E 539
Query: 269 AETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 328
K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF +TP
Sbjct: 540 GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTP 599
Query: 329 QETYRKV----MNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFE 384
+E + +V +NW E PP P ++ L+LR + R+G G E+K H FF
Sbjct: 600 EELFGQVISDEINWPEKDEAPP--PDAQDLITLLLR--QNPLERLGTGGAYEVKQHRFFR 655
Query: 385 GVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYK 444
+DW + + A +++S DDTS FD S+ + E D +D+ N +
Sbjct: 656 SLDWNSLLRQKAEFIPQLESEDDTSYFD--TRSEKYHHMETEEEDDTNDEDF---NVEIR 710
Query: 445 RFEGLTQRGS 454
+F + R S
Sbjct: 711 QFSSCSHRFS 720
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 223 bits (567), Expect = 4e-58
Identities = 121/337 (35%), Positives = 188/337 (55%), Gaps = 47/337 (13%)
Query: 88 DDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADG 147
D FE L+ +G G+FG V LV+ ++TG YAMKIL K +++ +QV HI E+ IL D
Sbjct: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101
Query: 148 AWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQL 207
++VK+ +SF+D LYL+ME++PGG+M + L + +E FY ++ VLA+ +H L
Sbjct: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSL 161
Query: 208 GFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKR 267
IHRD+KP+NLL+D +G+++++DFG +
Sbjct: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFA-----------------------------KRV 192
Query: 268 KAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 327
K TW + GTP+Y+APE+ + GYNK DWW+LGV++YEM +G+PPF ++
Sbjct: 193 KGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQ 243
Query: 328 PQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRIGN--SGVEEIKGHPFFE 384
P + Y K+++ + + FP + +S K L+ +D R GN +GV +IK H +F
Sbjct: 244 PIQIYEKIVSGR--VRFPSK--LSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFA 299
Query: 385 GVDWEHIRERPAAIPI--EIKSIDDTSNFDDFPESDI 419
W I E+ P + D SNFDD+ E ++
Sbjct: 300 TTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEEL 336
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 221 bits (564), Expect = 8e-58
Identities = 119/329 (36%), Positives = 185/329 (56%), Gaps = 24/329 (7%)
Query: 86 GLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEA 145
G +DF+++K+I GA+G V LV+ +DT +AMK + K +++ + Q+ ERDIL A
Sbjct: 370 GENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 429
Query: 146 DGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIH 205
+ +VV MF SF+ +R+L ++ME++ GGD TLL L E + Y +ETVLA++ +H
Sbjct: 430 ENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLH 489
Query: 206 QLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNS 265
G +HRD+KPDNLL+ + GH+KL+DFGL + T Y
Sbjct: 490 NYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLY------------------ 531
Query: 266 KRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS 325
+ K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF
Sbjct: 532 --EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG 589
Query: 326 ETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSEN--RIGNSGVEEIKGHPFF 383
+TP+E + +V++ + +++P L++ + + R+G G E+K H FF
Sbjct: 590 DTPEELFGQVIS--DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFF 647
Query: 384 EGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
+DW + + A ++S DDTS FD
Sbjct: 648 RDLDWTGLLRQKAEFIPHLESEDDTSYFD 676
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 221 bits (564), Expect = 8e-58
Identities = 145/431 (33%), Positives = 231/431 (53%), Gaps = 63/431 (14%)
Query: 21 VTVAKLTLENFYSNLILQHEERETRQKKLEVA-MEEEGLADEEKKLRRSQHARKETEFLR 79
+++ K + F+S + R++R K ++ +EEEG+ K++ S H ++ E
Sbjct: 3 LSMKKFAVRRFFSVYL----RRKSRSKSSSLSRLEEEGVV---KEIDISHHVKEGFE--- 52
Query: 80 LKRTRLGLDDFESLKVIGRGAFGEVRLVQK---KDTGHIYAMKILRKSDMLEKEQVAHIR 136
+ FE LKV+G+G++G+V LV+K D G +YAMK+L+K+ + +++V +
Sbjct: 53 ----KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-K 107
Query: 137 AERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISE 196
ERDIL E + ++VK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY++E
Sbjct: 108 MERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 167
Query: 197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPS 256
LA+D +H LG I+RD+KP+N+LLD +GH+K++DFGL
Sbjct: 168 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---------------------- 205
Query: 257 DFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEM 316
SK + K+ AYS GT +Y+APEV + G+ + DWWS GV+M+EM
Sbjct: 206 --------SKEAIDHDKR-----AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEM 252
Query: 317 LIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGN--SGV 374
L G PF + +ET ++ K + P+ E L F + NR+G GV
Sbjct: 253 LTGSLPFQGKDRKETMALILKAKLGM---PQFLSGEAQSLLRALFKRNPCNRLGAGIDGV 309
Query: 375 EEIKGHPFFEGVDWEHIRERPAAIPIE--IKSIDDTSNFDDFPESDILQPVPNTTEPDYK 432
EEIK HPFF +DW + + P + + +DT +FD PE P + P
Sbjct: 310 EEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD--PEFTARTPTDSPGVPPSA 367
Query: 433 SKDWVFLNYTY 443
+ +F +++
Sbjct: 368 NAHHLFRGFSF 378
Score = 101 bits (251), Expect = 2e-21
Identities = 73/291 (25%), Positives = 133/291 (45%), Gaps = 51/291 (17%)
Query: 88 DDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE-AD 146
D +E + IG G++ + K T YA+KI+ KS E++ +IL+
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI-------EILLRYGQ 465
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
++ + + D + +YL+ME + GG+++ ++++ +E E + +D +H
Sbjct: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 525
Query: 207 LGFIHRDIKPDNLLL-DAKG---HVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQN 262
G +HRD+KP N+L D G +++ DFG L+ +
Sbjct: 526 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGN-------------------- 565
Query: 263 MNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 322
L + T +++APEV + GY+ CD WSLG+++Y ML G+ P
Sbjct: 566 ---------------GLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTP 610
Query: 323 FCS---ETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRI 369
F + +TP+E ++ + K L IS+ AKD++ + +D R+
Sbjct: 611 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL 661
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 219 bits (558), Expect = 4e-57
Identities = 145/429 (33%), Positives = 228/429 (53%), Gaps = 61/429 (14%)
Query: 28 LENFYSNLILQHEERETRQKKLEVAMEE--EGLADEE----KKLRRSQHARKETEFLRLK 81
L + + ++ E ET ++ L + +E E A+EE K++ S H ++ E
Sbjct: 6 LLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFE----- 60
Query: 82 RTRLGLDDFESLKVIGRGAFGEVRLVQK---KDTGHIYAMKILRKSDMLEKEQVAHIRAE 138
+ FE LKV+G+G++G+V LV+K D G +YAMK+L+K+ + +++V + E
Sbjct: 61 --KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KME 117
Query: 139 RDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETV 198
RDIL E + ++VK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY++E
Sbjct: 118 RDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 177
Query: 199 LAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDF 258
LA+D +H LG I+RD+KP+N+LLD +GH+K++DFGL
Sbjct: 178 LALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL------------------------ 213
Query: 259 SFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLI 318
SK + K+ AYS GT +Y+APEV + G+ + DWWS GV+M+EML
Sbjct: 214 ------SKEAIDHDKR-----AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT 262
Query: 319 GYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGN--SGVEE 376
G PF + +ET ++ K + P+ E L F + NR+G GVEE
Sbjct: 263 GSLPFQGKDRKETMALILKAKLGM---PQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEE 319
Query: 377 IKGHPFFEGVDWEHIRERPAAIPIE--IKSIDDTSNFDDFPESDILQPVPNTTEPDYKSK 434
IK HPFF +DW + + P + + +DT +FD PE P + P +
Sbjct: 320 IKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD--PEFTARTPTDSPGVPPSANA 377
Query: 435 DWVFLNYTY 443
+F +++
Sbjct: 378 HHLFRGFSF 386
Score = 101 bits (251), Expect = 2e-21
Identities = 73/291 (25%), Positives = 133/291 (45%), Gaps = 51/291 (17%)
Query: 88 DDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE-AD 146
D +E + IG G++ + K T YA+KI+ KS E++ +IL+
Sbjct: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI-------EILLRYGQ 473
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
++ + + D + +YL+ME + GG+++ ++++ +E E + +D +H
Sbjct: 474 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 533
Query: 207 LGFIHRDIKPDNLLL-DAKG---HVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQN 262
G +HRD+KP N+L D G +++ DFG L+ +
Sbjct: 534 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGN-------------------- 573
Query: 263 MNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 322
L + T +++APEV + GY+ CD WSLG+++Y ML G+ P
Sbjct: 574 ---------------GLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTP 618
Query: 323 FCS---ETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRI 369
F + +TP+E ++ + K L IS+ AKD++ + +D R+
Sbjct: 619 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL 669
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 217 bits (553), Expect = 2e-56
Identities = 140/399 (35%), Positives = 214/399 (53%), Gaps = 51/399 (12%)
Query: 55 EEGLADEEKKLRRSQHARKE---TEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQK-- 109
+E + +EE + + + KE T ++ + FE LKV+G+G+FG+V LV+K
Sbjct: 30 DEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKIS 89
Query: 110 -KDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIME 168
D +YAMK+L+K+ + +++V + ERDILVE + ++VK+ Y+FQ + LYLI++
Sbjct: 90 GSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILD 148
Query: 169 FLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVK 228
FL GGD+ T L K+ TEE+ +FY++E LA+D +H LG I+RD+KP+N+LLD +GH+K
Sbjct: 149 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 208
Query: 229 LSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPD 288
L+DFGL SK + KK AYS GT +
Sbjct: 209 LTDFGL------------------------------SKESIDHEKK-----AYSFCGTVE 233
Query: 289 YIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEV 348
Y+APEV + G+ + DWWS GV+M+EML G PF + +ET ++ K + P+
Sbjct: 234 YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGM---PQF 290
Query: 349 PISEKAKDLILRFCIDSENRI--GNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKS-- 404
E L + F + NR+ G GVEEIK H FF +DW + R P + +
Sbjct: 291 LSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGR 350
Query: 405 IDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTY 443
+DT FD PE P + P + +F +++
Sbjct: 351 PEDTFYFD--PEFTAKTPKDSPGIPPSANAHQLFRGFSF 387
Score = 100 bits (250), Expect = 2e-21
Identities = 84/353 (23%), Positives = 162/353 (45%), Gaps = 60/353 (16%)
Query: 88 DDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE-AD 146
D +E + IG G++ + K T +A+KI+ KS E++ +IL+
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI-------EILLRYGQ 472
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
++ + + D + +Y++ E + GG+++ ++++ +E E + ++ +H
Sbjct: 473 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHA 532
Query: 207 LGFIHRDIKPDNLL-LDAKGH---VKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQN 262
G +HRD+KP N+L +D G+ +++ DFG L+ +
Sbjct: 533 QGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENG------------------- 573
Query: 263 MNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 322
L + T +++APEV + GY+ CD WSLGV++Y ML GY P
Sbjct: 574 ----------------LLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTP 617
Query: 323 FCS---ETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRIGNSGVEEIK 378
F + +TP+E ++ + K +L +S+ AKDL+ + +D R+ + V
Sbjct: 618 FANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLR-- 675
Query: 379 GHPFFEGVDWEHIRE----RPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTT 427
HP+ V W+ + + R A + ++ T + + +S +L+PV +T
Sbjct: 676 -HPWI--VHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRST 725
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 217 bits (552), Expect = 2e-56
Identities = 128/330 (38%), Positives = 189/330 (57%), Gaps = 46/330 (13%)
Query: 90 FESLKVIGRGAFGEVRLVQK---KDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEAD 146
FE LKV+G+G+FG+V LV+K D+GH+YAMK+L+K+ + +++V + ERDIL + +
Sbjct: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVN 129
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
+VVK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY++E L +D +H
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 189
Query: 207 LGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSK 266
LG I+RD+KP+N+LLD +GH+KL+DFGL SK
Sbjct: 190 LGIIYRDLKPENILLDEEGHIKLTDFGL------------------------------SK 219
Query: 267 RKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 326
+ KK AYS GT +Y+APEV + G++ DWWS GV+M+EML G PF +
Sbjct: 220 EAIDHEKK-----AYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGK 274
Query: 327 TPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGN--SGVEEIKGHPFFE 384
+ET ++ K + P+ +E L F + NR+G+ G EEIK H F+
Sbjct: 275 DRKETMTLILKAKLGM---PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 331
Query: 385 GVDWEHIRERPAAIPIE--IKSIDDTSNFD 412
+DW + R P + + DDT FD
Sbjct: 332 TIDWNKLYRREIKPPFKPAVAQPDDTFYFD 361
Score = 110 bits (276), Expect = 2e-24
Identities = 77/304 (25%), Positives = 144/304 (47%), Gaps = 54/304 (17%)
Query: 88 DDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE-AD 146
D + + IG G++ E + K T YA+K++ KS E++ +IL+
Sbjct: 425 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI-------EILLRYGQ 477
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
++ + + D +++YL+ E + GG+++ ++++ +E E F + ++ +H
Sbjct: 478 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 537
Query: 207 LGFIHRDIKPDNLL-LDAKGH---VKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQN 262
G +HRD+KP N+L +D G+ +++ DFG L+ +
Sbjct: 538 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENG------------------- 578
Query: 263 MNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 322
L + T +++APEV + GY++ CD WSLG+++Y ML GY P
Sbjct: 579 ----------------LLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 622
Query: 323 FC---SETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRIGNSGVEEIK 378
F S+TP+E ++ + K TL +SE AKDL+ + +D R+ +++
Sbjct: 623 FANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL---TAKQVL 679
Query: 379 GHPF 382
HP+
Sbjct: 680 QHPW 683
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 217 bits (552), Expect = 2e-56
Identities = 128/330 (38%), Positives = 189/330 (57%), Gaps = 46/330 (13%)
Query: 90 FESLKVIGRGAFGEVRLVQK---KDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEAD 146
FE LKV+G+G+FG+V LV+K D+GH+YAMK+L+K+ + +++V + ERDIL + +
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVN 120
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
+VVK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY++E L +D +H
Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180
Query: 207 LGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSK 266
LG I+RD+KP+N+LLD +GH+KL+DFGL SK
Sbjct: 181 LGIIYRDLKPENILLDEEGHIKLTDFGL------------------------------SK 210
Query: 267 RKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 326
+ KK AYS GT +Y+APEV + G++ DWWS GV+M+EML G PF +
Sbjct: 211 EAIDHEKK-----AYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGK 265
Query: 327 TPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGN--SGVEEIKGHPFFE 384
+ET ++ K + P+ +E L F + NR+G+ G EEIK H F+
Sbjct: 266 DRKETMTLILKAKLGM---PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 322
Query: 385 GVDWEHIRERPAAIPIE--IKSIDDTSNFD 412
+DW + R P + + DDT FD
Sbjct: 323 TIDWNKLYRREIKPPFKPAVAQPDDTFYFD 352
Score = 110 bits (276), Expect = 2e-24
Identities = 77/304 (25%), Positives = 144/304 (47%), Gaps = 54/304 (17%)
Query: 88 DDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE-AD 146
D + + IG G++ E + K T YA+K++ KS E++ +IL+
Sbjct: 416 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI-------EILLRYGQ 468
Query: 147 GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQ 206
++ + + D +++YL+ E + GG+++ ++++ +E E F + ++ +H
Sbjct: 469 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 528
Query: 207 LGFIHRDIKPDNLL-LDAKGH---VKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQN 262
G +HRD+KP N+L +D G+ +++ DFG L+ +
Sbjct: 529 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENG------------------- 569
Query: 263 MNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 322
L + T +++APEV + GY++ CD WSLG+++Y ML GY P
Sbjct: 570 ----------------LLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 613
Query: 323 FC---SETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRIGNSGVEEIK 378
F S+TP+E ++ + K TL +SE AKDL+ + +D R+ +++
Sbjct: 614 FANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL---TAKQVL 670
Query: 379 GHPF 382
HP+
Sbjct: 671 QHPW 674
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,954,537
Number of Sequences: 37866
Number of extensions: 828790
Number of successful extensions: 5545
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 661
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 3045
Number of HSP's gapped (non-prelim): 1840
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.