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Search of human proteins with 239787764
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
(369 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 757 0.0
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 757 0.0
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 640 0.0
gi|26665869 WD repeat domain 51B [Homo sapiens] 384 e-107
gi|23199987 WD repeat domain 5B [Homo sapiens] 156 3e-38
gi|16554629 WD repeat domain 5 [Homo sapiens] 153 3e-37
gi|16554627 WD repeat domain 5 [Homo sapiens] 153 3e-37
gi|32189425 WD repeat domain 69 [Homo sapiens] 151 1e-36
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 146 3e-35
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 129 5e-30
gi|21071067 TBP-associated factor 5 [Homo sapiens] 126 3e-29
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 125 6e-29
gi|113865883 WD repeat domain 38 [Homo sapiens] 125 8e-29
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 124 1e-28
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 118 7e-27
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 116 3e-26
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 116 3e-26
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 116 3e-26
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 116 3e-26
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 116 3e-26
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 113 2e-25
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 112 7e-25
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 111 9e-25
gi|19913367 transducin beta-like 1Y [Homo sapiens] 111 9e-25
gi|19913365 transducin beta-like 1Y [Homo sapiens] 111 9e-25
gi|15150805 transducin beta-like 1Y [Homo sapiens] 111 9e-25
gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens] 110 2e-24
gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens] 110 2e-24
gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens] 110 2e-24
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 110 3e-24
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 757 bits (1955), Expect = 0.0
Identities = 369/369 (100%), Positives = 369/369 (100%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
Query: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
Query: 241 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR 300
FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR
Sbjct: 241 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR 300
Query: 301 GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ 360
GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ
Sbjct: 301 GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ 360
Query: 361 QLIMQRATP 369
QLIMQRATP
Sbjct: 361 QLIMQRATP 369
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 757 bits (1955), Expect = 0.0
Identities = 369/369 (100%), Positives = 369/369 (100%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV
Sbjct: 39 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 98
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR
Sbjct: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
Query: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218
Query: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA
Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
Query: 241 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR 300
FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR
Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR 338
Query: 301 GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ 360
GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ
Sbjct: 339 GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ 398
Query: 361 QLIMQRATP 369
QLIMQRATP
Sbjct: 399 QLIMQRATP 407
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/102 (31%), Positives = 45/102 (44%), Gaps = 4/102 (3%)
Query: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
L +H++ H AV + F + L + S DS L + + Y GH+ T V FS
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 243 RTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLAS 284
+G ASG D+ V +W N GE T AT+ S
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNV----KGESTVFRAHTATVRS 108
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 640 bits (1651), Expect = 0.0
Identities = 321/369 (86%), Positives = 321/369 (86%), Gaps = 48/369 (13%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV
Sbjct: 39 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 98
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR
Sbjct: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
Query: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218
Query: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA
Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
Query: 241 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR 300
FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNL
Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNL----------- 327
Query: 301 GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ 360
TVSILEQRLTLTEDKLKQCLENQ
Sbjct: 328 -------------------------------------TVSILEQRLTLTEDKLKQCLENQ 350
Query: 361 QLIMQRATP 369
QLIMQRATP
Sbjct: 351 QLIMQRATP 359
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/102 (31%), Positives = 45/102 (44%), Gaps = 4/102 (3%)
Query: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
L +H++ H AV + F + L + S DS L + + Y GH+ T V FS
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 243 RTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLAS 284
+G ASG D+ V +W N GE T AT+ S
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNV----KGESTVFRAHTATVRS 108
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 384 bits (985), Expect = e-107
Identities = 178/297 (59%), Positives = 232/297 (78%), Gaps = 12/297 (4%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D+ LM+W+ KP +RAYR+ GHKD VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F
Sbjct: 39 DTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEF 98
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
+AHTA VRSV F +DGQ TAS+DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRL
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
IVS S+DKT+K+WD ++++CV+++ + GF +VDF+PSGTCIA+AG D TVKVWDVR +
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218
Query: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 241
+LLQHYQ+HS VN +SFHPSGNYLITASSD TLKILDL+EGRL+YTL GH GP TV+F
Sbjct: 219 KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSF 278
Query: 242 SRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPP 298
S+ GE FASGG+D QV++W++NFD + +TK NL + F PP
Sbjct: 279 SKGGELFASGGADTQVLLWRTNFDELHCKGLTK------------RNLKRLHFDSPP 323
Score = 110 bits (275), Expect = 2e-24
Identities = 64/200 (32%), Positives = 92/200 (46%)
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
F+ H A + S+ +G+ TAS D + +W + H + V +FSP G
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
L+ SAS D+TV+LW R + H V VDF G +A A D ++KVW +
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
Query: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
R L H+ V F P G +++ S D T+KI D + + G A V
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193
Query: 241 FSRTGEYFASGGSDEQVMVW 260
F+ +G AS GSD+ V VW
Sbjct: 194 FNPSGTCIASAGSDQTVKVW 213
Score = 48.5 bits (114), Expect = 9e-06
Identities = 26/78 (33%), Positives = 38/78 (48%)
Query: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
L ++++ H AA+ L P+G L TAS D+ L + + Y GH+ T+V FS
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 243 RTGEYFASGGSDEQVMVW 260
G AS D V +W
Sbjct: 70 PHGNLLASASRDRTVRLW 87
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 156 bits (394), Expect = 3e-38
Identities = 89/245 (36%), Positives = 136/245 (55%), Gaps = 6/245 (2%)
Query: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 79
GH +AV+ V FSP+G LAS S D+ + IW + K E T++ H + V + SD
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSR 97
Query: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
V+ASDDKT+K+W K L +L H N+V C F+P LI+S S D+TVK+W+ +
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH-YQLHSAAVNGLS 198
+C+ + H V+ V F+ SG+ I + D ++WD + + L+ + V+ +
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
Query: 199 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYFASGGSDE 255
F P+G Y++TA+ D+TLK+ D GR L T GH+ + FS T G++ SG D
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
Query: 256 QVMVW 260
V +W
Sbjct: 278 LVYIW 282
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/159 (30%), Positives = 81/159 (50%)
Query: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161
+L H V KFSP+G + S+S D+ + +W + + H ++ V +
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 162 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 221
+ + +A D T+K+WDVR+ + L+ + HS V +F+P N +I+ S D T+KI ++
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 222 EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
G+ L TL H P + V F+ +G SG D +W
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 61.6 bits (148), Expect = 1e-09
Identities = 34/142 (23%), Positives = 69/142 (48%)
Query: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
+L +S+S +++ ++ + + + H V+ V F P+G +A++ D + +W
Sbjct: 12 QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY 71
Query: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239
+ + H+ ++ +++ + L++AS D TLK+ D+ G+ L TL GH
Sbjct: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
Query: 240 AFSRTGEYFASGGSDEQVMVWK 261
F+ SG DE V +W+
Sbjct: 132 NFNPPSNLIISGSFDETVKIWE 153
Score = 44.7 bits (104), Expect = 1e-04
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 7/101 (6%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCV--NFS-PSGHLLASGSRDKTVRIWVPNVKGE 57
+D+ L +W +TGHK+ C+ NFS G + SGS D V IW K
Sbjct: 230 LDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 289
Query: 58 STVFRAHTATVRSVHFCSDGQSFVTAS---DDKTVKVWATH 95
+ HT V S C ++ + ++ +DKT+K+W ++
Sbjct: 290 VQKLQGHTDVVISA-ACHPTENLIASAALENDKTIKLWMSN 329
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 153 bits (386), Expect = 3e-37
Identities = 90/252 (35%), Positives = 139/252 (55%), Gaps = 8/252 (3%)
Query: 16 AYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVH 72
A +FT GH AV+ V FSP+G LAS S DK ++IW + K E T+ H + V
Sbjct: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVA 94
Query: 73 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 132
+ SD V+ASDDKT+K+W K L +L H N+V C F+P LIVS S D++V+
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 133 LWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH-YQLHS 191
+WD + +C+ + H V+ V F+ G+ I ++ D ++WD + + L+ +
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 192 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYF 248
V+ + F P+G Y++ A+ D+TLK+ D +G+ L T GH+ + FS T G++
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 249 ASGGSDEQVMVW 260
SG D V +W
Sbjct: 275 VSGSEDNLVYIW 286
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCV--NFS-PSGHLLASGSRDKTVRIWVPNVKGE 57
+D+ L +W +TGHK+ C+ NFS G + SGS D V IW K
Sbjct: 234 LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
Query: 58 STVFRAHTATVRSVHFCSDGQSFVTAS---DDKTVKVW 92
+ HT V S C ++ + ++ +DKT+K+W
Sbjct: 294 VQKLQGHTDVVIST-ACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 153 bits (386), Expect = 3e-37
Identities = 90/252 (35%), Positives = 139/252 (55%), Gaps = 8/252 (3%)
Query: 16 AYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVH 72
A +FT GH AV+ V FSP+G LAS S DK ++IW + K E T+ H + V
Sbjct: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVA 94
Query: 73 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 132
+ SD V+ASDDKT+K+W K L +L H N+V C F+P LIVS S D++V+
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 133 LWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH-YQLHS 191
+WD + +C+ + H V+ V F+ G+ I ++ D ++WD + + L+ +
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 192 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYF 248
V+ + F P+G Y++ A+ D+TLK+ D +G+ L T GH+ + FS T G++
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 249 ASGGSDEQVMVW 260
SG D V +W
Sbjct: 275 VSGSEDNLVYIW 286
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCV--NFS-PSGHLLASGSRDKTVRIWVPNVKGE 57
+D+ L +W +TGHK+ C+ NFS G + SGS D V IW K
Sbjct: 234 LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
Query: 58 STVFRAHTATVRSVHFCSDGQSFVTAS---DDKTVKVW 92
+ HT V S C ++ + ++ +DKT+K+W
Sbjct: 294 VQKLQGHTDVVIST-ACHPTENIIASAALENDKTIKLW 330
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 151 bits (381), Expect = 1e-36
Identities = 80/260 (30%), Positives = 128/260 (49%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D +W ++ + F GH + C++F+P L+A+GS D T ++W E
Sbjct: 156 DKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
R H+A + S+ F + G +T S D TV VW + + L H + A F+ D L
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSL 275
Query: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
I++ S DKT KLWD ++ +CV + H + F +G IA A D T +++ T
Sbjct: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
Query: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 241
+ + + H ++ +SF+P GN+L+T SSD T +I D G+ L L GH + AF
Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAF 395
Query: 242 SRTGEYFASGGSDEQVMVWK 261
+ G +G D +W+
Sbjct: 396 NYKGNIVITGSKDNTCRIWR 415
Score = 120 bits (302), Expect = 1e-27
Identities = 62/217 (28%), Positives = 111/217 (51%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
MD+ +W ++ Y GH + ++F+ SG + +GS D TV +W + + +
Sbjct: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI 256
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
H A + S F D +T S DKT K+W K + +L+ H + + + F G+
Sbjct: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
Query: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
LI +AS D T +++ ++R+C+ H G ++ + F+P G + D T ++WD +T
Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376
Query: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
+ LQ + H+ + +F+ GN +IT S D+T +I
Sbjct: 377 GQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Score = 117 bits (292), Expect = 2e-26
Identities = 69/238 (28%), Positives = 108/238 (45%), Gaps = 1/238 (0%)
Query: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSFVTAS 84
+T V + SG +GS D+T ++W E H V ++ F + G T S
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 85 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 144
DKT K+W+ K + H + C F+P L+ + S D T KLWD + E V++
Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
Query: 145 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 204
H + + F+ SG I D+TV VWD T R + H A ++ SF+ +
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
Query: 205 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 262
++T S D T K+ D G+ + TL GH F TG+ A+ +D ++ +
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332
Score = 116 bits (291), Expect = 3e-26
Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 1/202 (0%)
Query: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF-SPD 118
V +AH + +V G F+T S D+T K+W T + L +L H N V F +P
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
Query: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
G I + S DKT KLW + +C H++ H + + F+P T +A MD T K+WD+
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 238
+ + + HSA + LSF+ SG+ +IT S D T+ + D GR + L GH ++
Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
Query: 239 VAFSRTGEYFASGGSDEQVMVW 260
+F+ +G D+ +W
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLW 288
Score = 96.7 bits (239), Expect = 3e-20
Identities = 59/198 (29%), Positives = 98/198 (49%), Gaps = 12/198 (6%)
Query: 78 QSFVTASDDKTVKVWATHRQK----------FLFS-LSQHINWVRCAKFSPDGRLIVSAS 126
+ +TAS + VK+ Q+ +LF L HI + + G ++ S
Sbjct: 52 EPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGS 111
Query: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQ 185
D+T KLWD +S E +++ H V + F+ P G IA D T K+W V T +
Sbjct: 112 YDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYH 171
Query: 186 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 245
++ H+A + LSF+P + T S D+T K+ D+ G +YTL GH +++F+ +G
Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSG 231
Query: 246 EYFASGGSDEQVMVWKSN 263
+ +G D V+VW ++
Sbjct: 232 DRIITGSFDHTVVVWDAD 249
Score = 64.7 bits (156), Expect = 1e-10
Identities = 34/134 (25%), Positives = 56/134 (41%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
MD +W TGH D + F +G L+A+ S D T RI+ +
Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK 340
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
H + + F G +T S DKT ++W + L L H + + F+ G
Sbjct: 341 LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGN 400
Query: 121 LIVSASDDKTVKLW 134
++++ S D T ++W
Sbjct: 401 IVITGSKDNTCRIW 414
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 146 bits (369), Expect = 3e-35
Identities = 84/282 (29%), Positives = 135/282 (47%), Gaps = 24/282 (8%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60
D+ + VW + GH D+V ++F SG LLAS S D T+++W + +G +
Sbjct: 129 DATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW--DFQGFECIR 186
Query: 61 -FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
H V SV +G V+AS DKT+K+W + + + H WVR + + DG
Sbjct: 187 TMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDG 246
Query: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS------------------- 160
LI S S+D+TV++W +++EC EH V + + P
Sbjct: 247 TLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGK 306
Query: 161 -GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219
G + + D T+K+WDV T L H V G+ FH G ++++ + D TL++ D
Sbjct: 307 PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366
Query: 220 LMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
R + TL+ H+ T++ F +T Y +G D+ V VW+
Sbjct: 367 YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 130 bits (327), Expect = 2e-30
Identities = 79/273 (28%), Positives = 125/273 (45%), Gaps = 21/273 (7%)
Query: 8 WHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT 67
W +P + Y +GH+ VT V F P ++ S S D T+++W + HT +
Sbjct: 94 WIPRPPEK-YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152
Query: 68 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 127
V+ + F G+ + S D T+K+W + + ++ H + V P+G IVSAS
Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
Query: 128 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 187
DKT+K+W+ + CV ++ H +V V + GT IA+ D TV+VW V T
Sbjct: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
Query: 188 QLHSAAVNGLSFHPSGNY--------------------LITASSDSTLKILDLMEGRLLY 227
+ H V +S+ P +Y L++ S D T+K+ D+ G L
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
Query: 228 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
TL GH V F G++ S D+ + VW
Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 115 bits (288), Expect = 6e-26
Identities = 62/198 (31%), Positives = 95/198 (47%), Gaps = 20/198 (10%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D + +W ++ FTGH++ V V + G L+AS S D+TVR+WV K
Sbjct: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
Query: 62 RAHTATVRSVHFCSD--------------------GQSFVTASDDKTVKVWATHRQKFLF 101
R H V + + + G ++ S DKT+K+W L
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
Query: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161
+L H NWVR F G+ I+S +DDKT+++WD ++ C+ + H FVT +DFH +
Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA 392
Query: 162 TCIAAAGMDNTVKVWDVR 179
+ +D TVKVW+ R
Sbjct: 393 PYVVTGSVDQTVKVWECR 410
Score = 75.5 bits (184), Expect = 7e-14
Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 7/148 (4%)
Query: 148 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 207
H VT V FHP + + +A D T+KVWD T + + H+ +V +SF SG L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 208 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF--- 264
+ S+D T+K+ D + T+HGH ++VA G++ S D+ + +W+
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
Query: 265 --DIVDHGEVTKVPRP--PATLASSMGN 288
H E ++ RP TL +S N
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSN 254
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 129 bits (323), Expect = 5e-30
Identities = 76/237 (32%), Positives = 115/237 (48%), Gaps = 3/237 (1%)
Query: 34 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 93
SG LLA+G D V +W N HT+ V SV + + V S +++VW
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Query: 94 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 153
K L +L H + F P G + S S D +KLWD + CV Y H V
Sbjct: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
Query: 154 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 213
+ F P G +A+A D+TVK+WD+ +++ + H+ VN + FHP+ L + SSD
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
Query: 214 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE-QVMVWKSN--FDIV 267
T++ DL + +++ + G GP +V F+ G SG D +V W+ FD+V
Sbjct: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV 268
Score = 122 bits (306), Expect = 5e-28
Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 1/199 (0%)
Query: 63 AHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
AH + V S+ + G+ T DD V +W+ ++ + SL+ H + V + + L
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
IV+ S ++++WD + + + + H + +DFHP G +A+ D +K+WD+R
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 241
+ Y+ HS AV L F P G +L +A+ D T+K+ DL G+++ GH GP V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 242 SRTGEYFASGGSDEQVMVW 260
ASG SD + W
Sbjct: 198 HPNEYLLASGSSDRTIRFW 216
Score = 120 bits (301), Expect = 2e-27
Identities = 62/213 (29%), Positives = 104/213 (48%), Gaps = 1/213 (0%)
Query: 2 DSCLM-VWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
D C + +W + + TGH V V + L+ +GS+ ++R+W
Sbjct: 41 DDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRT 100
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
H A + S+ F G+ + S D +K+W R+ +F H VRC +FSPDG+
Sbjct: 101 LMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK 160
Query: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
+ SA+DD TVKLWD ++ + + + H G V V+FHP+ +A+ D T++ WD+
Sbjct: 161 WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
Query: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 213
+++ + V + F+P G L + DS
Sbjct: 221 FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 126 bits (317), Expect = 3e-29
Identities = 75/244 (30%), Positives = 115/244 (47%), Gaps = 11/244 (4%)
Query: 17 YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 76
Y F +T V+ + L+A G D TVR+W K +RSV SD
Sbjct: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPK-----------KLRSVKQASD 512
Query: 77 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 136
SDD ++ L L H V A FSPD ++S+S+D TV+LW
Sbjct: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
Query: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196
+ C+ Y H V F P G + G D ++W ++ L+ + H A VN
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
Query: 197 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 256
FHP+ NY+ T S+D T+++ D++ G + GH+GP ++ FS G + A+G +D +
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692
Query: 257 VMVW 260
V++W
Sbjct: 693 VLLW 696
Score = 110 bits (275), Expect = 2e-24
Identities = 59/202 (29%), Positives = 96/202 (47%)
Query: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
GH V +FSP + L S S D TVR+W ++ H V F G F
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
Query: 81 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140
V+ D+ ++WAT + L + H+ V C +F P+ + + S D+TV+LWD +
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 200
CV + H G + + F P+G +A D V +WD+ ++ + H+ V L F
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
Query: 201 PSGNYLITASSDSTLKILDLME 222
G L + S D+T+++ D ++
Sbjct: 721 RDGEILASGSMDNTVRLWDAIK 742
Score = 89.4 bits (220), Expect = 5e-18
Identities = 49/176 (27%), Positives = 76/176 (43%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D + +W ++ + + GH V FSP G+ SG D+ R+W + +F
Sbjct: 564 DGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF 623
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
H A V F + T S D+TV++W + + H + FSP+GR
Sbjct: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF 683
Query: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
+ + + D V LWD V H V + F G +A+ MDNTV++WD
Sbjct: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 61.6 bits (148), Expect = 1e-09
Identities = 42/154 (27%), Positives = 59/154 (38%), Gaps = 31/154 (20%)
Query: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL----------- 189
C +++ +T VD + IA D+TV+VW V +L Q
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
Query: 190 --------------------HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 229
HS V G SF P NYL+++S D T+++ L L
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 230 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
GH P FS G YF SGG D +W ++
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 125 bits (314), Expect = 6e-29
Identities = 79/241 (32%), Positives = 118/241 (48%), Gaps = 3/241 (1%)
Query: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQS 79
GH D ++ F PSG LA+ S D TV++W KG+ + F H+ V S + S G
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLW-DLCKGDCILTFEGHSRAVWSCTWHSCGNF 450
Query: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
++S DKT K+W + ++ +L H + V +F P ++++S DKT+ +WD +
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
Query: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199
C S H + F P G IA+ K+WD R + + + N ++F
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
Query: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
SG L AS + + +LDL G ++ L GH+ A TV FS GE SGGSD V
Sbjct: 571 DSSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRT 629
Query: 260 W 260
W
Sbjct: 630 W 630
Score = 103 bits (257), Expect = 2e-22
Identities = 59/201 (29%), Positives = 91/201 (45%)
Query: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
+FR H V V V+ +D+ KV + L + H +W+ F P G
Sbjct: 347 IFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSG 406
Query: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
+ ++S D TVKLWD +C+ ++ H V +H G +A++ +D T K+WDV
Sbjct: 407 DKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVN 466
Query: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239
+ R H+ +VN + F P N L+T+S+D TL I D G +L+GH
Sbjct: 467 SERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDA 526
Query: 240 AFSRTGEYFASGGSDEQVMVW 260
F G AS + +W
Sbjct: 527 IFDPRGHMIASCDACGVTKLW 547
Score = 80.9 bits (198), Expect = 2e-15
Identities = 59/218 (27%), Positives = 93/218 (42%), Gaps = 7/218 (3%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D+ + +W + F GH AV + G+ +AS S DKT +IW N +
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
HT +V S+ F + +T+S DKT+ +W SL H++ + A F P G +
Sbjct: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHM 534
Query: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT- 180
I S KLWD + S V+F SG +A A + + + D+++
Sbjct: 535 IASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSG 594
Query: 181 --HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 216
H+L+ H V F G L + SD T++
Sbjct: 595 EIHKLMGHENEAHTVV----FSHDGEILFSGGSDGTVR 628
Score = 76.6 bits (187), Expect = 3e-14
Identities = 42/159 (26%), Positives = 76/159 (47%)
Query: 110 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 169
V C P ++VS +D+ K+ + + H +++ FHPSG +A +
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 170 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 229
D TVK+WD+ + ++ HS AV ++H GN++ ++S D T KI D+ R TL
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
Query: 230 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 268
+GH ++ F + +D+ + +W + I +
Sbjct: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513
Score = 58.5 bits (140), Expect = 9e-09
Identities = 40/176 (22%), Positives = 65/176 (36%), Gaps = 1/176 (0%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
+D +W + + GH D+V + F P + L + S DKT+ IW
Sbjct: 456 LDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQS 515
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
H ++ F G + K+W + + S+ + F GR
Sbjct: 516 LYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGR 575
Query: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
++ AS + + L D S E +H H V F G + + G D TV+ W
Sbjct: 576 VLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 40.4 bits (93), Expect = 0.003
Identities = 21/80 (26%), Positives = 38/80 (47%)
Query: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
++L ++LH V+ +S P + L++ D K+L L + +L T GH +
Sbjct: 342 YKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCC 401
Query: 241 FSRTGEYFASGGSDEQVMVW 260
F +G+ A+ D V +W
Sbjct: 402 FHPSGDKLATSSGDTTVKLW 421
Score = 33.9 bits (76), Expect = 0.24
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 1/65 (1%)
Query: 29 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 88
VNF SG +LA S + + + + GE H +V F DG+ + D T
Sbjct: 568 VNFDSSGRVLAQASGNGVIHL-LDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGT 626
Query: 89 VKVWA 93
V+ W+
Sbjct: 627 VRTWS 631
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 125 bits (313), Expect = 8e-29
Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)
Query: 15 RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 71
R +F G H V FSP G +L +GS D V W + ++R HT V+
Sbjct: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69
Query: 72 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 131
F DG F +AS D TV++W R K L L H V FSPD R + S DK V
Sbjct: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
Query: 132 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 185
LWD S + + H + DF P+ C+A D+TV +WD+R +H+ L+
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
Query: 186 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 245
HSA ++ L + SG L + S D T+ I LL L GH ++AFS
Sbjct: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
Query: 246 EYFASGGSDEQVMVWKSN 263
+ AS G V VW N
Sbjct: 246 LWLASAGYSRMVKVWDCN 263
Score = 116 bits (290), Expect = 4e-26
Identities = 76/257 (29%), Positives = 115/257 (44%), Gaps = 4/257 (1%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D C+ W + +R GH V FSP GHL AS S D TVR+W V
Sbjct: 42 DGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL 101
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
+ H +V +V F D + + DK V +W + L L H + ++ + FSP
Sbjct: 102 KGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC 161
Query: 122 IVSASDDKTVKLWDKS--SRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
+ + S D TV +WD + H E H ++ + + SG +A+ D T+ +W
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKP 220
Query: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 238
T LL + H V ++F P +L +A +K+ D G+ L TL G A T
Sbjct: 221 TTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHT 280
Query: 239 VAFSRTGEYFASGGSDE 255
AF+ G+ SG +D+
Sbjct: 281 CAFTPDGKILVSGAADQ 297
Score = 77.0 bits (188), Expect = 2e-14
Identities = 44/141 (31%), Positives = 72/141 (51%), Gaps = 4/141 (2%)
Query: 2 DSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 58
DS + +W ++ P GH ++C+ +S SG LLASGS DKT+ IW P
Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLL 226
Query: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
+ H V+S+ F D +A + VKVW + K L +L ++ F+PD
Sbjct: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
Query: 119 GRLIVSASDDKTVKLWDKSSR 139
G+++VS + D+T + ++S+
Sbjct: 287 GKILVSGAADQTRRQISRTSK 307
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 124 bits (312), Expect = 1e-28
Identities = 76/257 (29%), Positives = 130/257 (50%), Gaps = 23/257 (8%)
Query: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 76
+GH+ V C F P+G LAS D+ + +W NV G+ + H+ V +H+ +D
Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120
Query: 77 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 135
G +AS DKTV VW + + + L H ++V C +L+ + SDD TVKLWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195
+ + ++ ++ V V F+ + I + G+DN +KVWD+R ++L + H+ +V
Sbjct: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
Query: 196 GLSFHPSGNYLITASSDSTLKILD------------LMEGRLLYTLHGHQGPATTVAFSR 243
GLS G+YL++ + D+T+++ D + +G +H + ++S
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG----NVHNFEKNLLRCSWSP 295
Query: 244 TGEYFASGGSDEQVMVW 260
G A+G +D V VW
Sbjct: 296 DGSKIAAGSADRFVYVW 312
Score = 96.3 bits (238), Expect = 4e-20
Identities = 63/226 (27%), Positives = 104/226 (46%), Gaps = 16/226 (7%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAV-TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
D + VW + R R GH V +C L+ +GS D TV++W K
Sbjct: 130 DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT 189
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
F+ +T V +V F ++ D +KVW + K +++ H + V S +G
Sbjct: 190 FQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGS 248
Query: 121 LIVSASDDKTVKLWD-----------KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 169
++S + D TV++WD K + VH++ ++ + + P G+ IAA
Sbjct: 249 YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN---LLRCSWSPDGSKIAAGSA 305
Query: 170 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 215
D V VWD + R+L H+ ++N ++FHP +I+ASSD L
Sbjct: 306 DRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 80.5 bits (197), Expect = 2e-15
Identities = 56/202 (27%), Positives = 83/202 (41%), Gaps = 45/202 (22%)
Query: 103 LSQHINWVRCAKFSP-------------------------------------------DG 119
LS H V C KF P DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN-TVKVWDV 178
++ SAS DKTV +WD + E V H FV G + G D+ TVK+WD+
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 238
R +Q +Q ++ V ++F+ + + +I+ D+ +K+ DL + +L YT+ GH T
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 239 VAFSRTGEYFASGGSDEQVMVW 260
++ S G Y S D V VW
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVW 262
Score = 72.0 bits (175), Expect = 8e-13
Identities = 47/187 (25%), Positives = 85/187 (45%), Gaps = 11/187 (5%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D + +W ++ ++ F V V F+ + + SG D +++W +
Sbjct: 173 DGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM 231
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH------RQKFLFSLSQHI---NWVRC 112
R H +V + S+G ++ + D TV+VW R +F + H N +RC
Sbjct: 232 RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291
Query: 113 AKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT 172
+ +SPDG I + S D+ V +WD +SR ++ H G + V FHP I +A D
Sbjct: 292 S-WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKR 350
Query: 173 VKVWDVR 179
+ + +++
Sbjct: 351 LYMGEIQ 357
Score = 68.9 bits (167), Expect = 7e-12
Identities = 42/139 (30%), Positives = 64/139 (46%), Gaps = 12/139 (8%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
+D+ + VW ++ Y GH D+VT ++ S G L S + D TVR+W +V+ +
Sbjct: 213 IDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVW--DVRPFAPK 270
Query: 61 FRAHTATVRSVH----------FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV 110
R +VH + DG S D+ V VW T ++ L+ L H +
Sbjct: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSI 330
Query: 111 RCAKFSPDGRLIVSASDDK 129
F PD +I+SAS DK
Sbjct: 331 NEVAFHPDEPIIISASSDK 349
Score = 37.7 bits (86), Expect = 0.017
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 248
H V FHP+G+ L +A D + + ++ Y TL GH G + ++ G
Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
Query: 249 ASGGSDEQVMVWKS 262
S +D+ V VW S
Sbjct: 125 FSASTDKTVAVWDS 138
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 118 bits (296), Expect = 7e-27
Identities = 83/279 (29%), Positives = 131/279 (46%), Gaps = 23/279 (8%)
Query: 2 DSCLMVWHMKPQSRAY-----RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKG 56
D +++W + Y GH V+ V S G SGS D T+R+W
Sbjct: 37 DKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT 96
Query: 57 ESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ-KFLFSLSQHINWVRCAKF 115
+ F HT V SV F SD + V+ S DKT+K+W T K+ H WV C +F
Sbjct: 97 TTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRF 156
Query: 116 SPDGR--LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173
SP+ +IVS DK VK+W+ ++ + ++ H G++ V P G+ A+ G D
Sbjct: 157 SPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQA 216
Query: 174 KVWDVRTHRLLQHYQLHSA-AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY----- 227
+WD+ + L Y L +N L F P+ Y + A++ ++KI DL EG+++
Sbjct: 217 MLWDLNEGKHL--YTLDGGDIINALCFSPN-RYWLCAATGPSIKIWDL-EGKIIVDELKQ 272
Query: 228 -----TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
+ T++A+S G+ +G +D V VW+
Sbjct: 273 EVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
Score = 97.8 bits (242), Expect = 1e-20
Identities = 73/250 (29%), Positives = 111/250 (44%), Gaps = 13/250 (5%)
Query: 21 GHKDAVTCVNFSPS-GHLLASGSRDKTVRIW-----VPNVKGESTVFRAHTATVRSVHFC 74
GH VT + +P ++ S SRDKT+ +W N R H+ V V
Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72
Query: 75 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
SDGQ ++ S D T+++W H V FS D R IVS S DKT+KLW
Sbjct: 73 SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132
Query: 135 DKSSRECVHSYCE--HGGFVTYVDFHP--SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 190
+ + C ++ + H +V+ V F P S I + G D VKVW++ +L ++ H
Sbjct: 133 N-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGH 191
Query: 191 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 250
+ +N ++ P G+ + D + DL EG+ LYTL G G Y+
Sbjct: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG--GDIINALCFSPNRYWLC 249
Query: 251 GGSDEQVMVW 260
+ + +W
Sbjct: 250 AATGPSIKIW 259
Score = 80.5 bits (197), Expect = 2e-15
Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 8/191 (4%)
Query: 81 VTASDDKTVKVWATHRQKFLFSLSQ-----HINWVRCAKFSPDGRLIVSASDDKTVKLWD 135
++AS DKT+ +W R + + + Q H ++V S DG+ +S S D T++LWD
Sbjct: 32 LSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
Query: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAV 194
++ + H V V F I + D T+K+W+ + + + HS V
Sbjct: 92 LTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWV 151
Query: 195 NGLSFHPSGN--YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 252
+ + F P+ + +++ D +K+ +L +L GH G TV S G ASGG
Sbjct: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211
Query: 253 SDEQVMVWKSN 263
D Q M+W N
Sbjct: 212 KDGQAMLWDLN 222
Score = 62.8 bits (151), Expect = 5e-10
Identities = 58/231 (25%), Positives = 80/231 (34%), Gaps = 56/231 (24%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D L +W + + RF GH V V FS + SGSRDKT+++W + TV
Sbjct: 84 DGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQ 143
Query: 62 -RAHTATVRSVHFCSDGQS--FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
+H+ V V F + + V+ DK VKVW K + H ++ SPD
Sbjct: 144 DESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPD 203
Query: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV-------------------------- 152
G L S D LWD + E H Y GG +
Sbjct: 204 GSLCASGGKDGQAMLWDLN--EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDL 261
Query: 153 -------------------------TYVDFHPSGTCIAAAGMDNTVKVWDV 178
T + + G + A DN V+VW V
Sbjct: 262 EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
Score = 48.9 bits (115), Expect = 7e-06
Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 6/121 (4%)
Query: 148 HGGFVTYVDFHPS-GTCIAAAGMDNTVKVW----DVRTHRLLQH-YQLHSAAVNGLSFHP 201
H G+VT + P I +A D T+ +W D + + Q + HS V+ +
Sbjct: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73
Query: 202 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
G + ++ S D TL++ DL G GH +VAFS SG D+ + +W
Sbjct: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Query: 262 S 262
+
Sbjct: 134 T 134
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 116 bits (291), Expect = 3e-26
Identities = 75/262 (28%), Positives = 123/262 (46%), Gaps = 15/262 (5%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D+ L VW GH V + ++ SGS D+T+++W
Sbjct: 282 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTL 339
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
HT+TVR +H + V+ S D T++VW + L L H+ VRC ++ DGR
Sbjct: 340 YGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRR 395
Query: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
+VS + D VK+WD + C+H+ H V + F G + + +D +++VWDV T
Sbjct: 396 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETG 453
Query: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG---HQGPATT 238
+ H + +G+ N L++ ++DST+KI D+ G+ L TL G HQ T
Sbjct: 454 NCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 511
Query: 239 VAFSRTGEYFASGGSDEQVMVW 260
+ F++ + + D V +W
Sbjct: 512 LQFNK--NFVITSSDDGTVKLW 531
Score = 106 bits (264), Expect = 4e-23
Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 13/241 (5%)
Query: 21 GHKD-AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79
GH D +TC+ F G+ + SGS D T+++W HT V S +
Sbjct: 260 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 315
Query: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
++ S D+T+KVW + + +L H + VRC + +VS S D T+++WD +
Sbjct: 316 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 373
Query: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199
+C+H H V V + G + + D VKVWD T L Q H+ V L F
Sbjct: 374 QCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 431
Query: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
G ++++ S D+++++ D+ G ++TL GHQ + T SG +D V +
Sbjct: 432 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKI 487
Query: 260 W 260
W
Sbjct: 488 W 488
Score = 79.7 bits (195), Expect = 4e-15
Identities = 51/188 (27%), Positives = 93/188 (49%), Gaps = 11/188 (5%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D+ L VW ++ + GH AV CV + G + SG+ D V++W P +
Sbjct: 362 DATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTL 419
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
+ HT V S+ F DG V+ S D +++VW + +L+ H + + + +
Sbjct: 420 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--I 475
Query: 122 IVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
+VS + D TVK+WD + +C+ + +H VT + F+ + + + D TVK+WD+
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 533
Query: 179 RTHRLLQH 186
+T +++
Sbjct: 534 KTGEFIRN 541
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 116 bits (291), Expect = 3e-26
Identities = 75/262 (28%), Positives = 123/262 (46%), Gaps = 15/262 (5%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D+ L VW GH V + ++ SGS D+T+++W
Sbjct: 400 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTL 457
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
HT+TVR +H + V+ S D T++VW + L L H+ VRC ++ DGR
Sbjct: 458 YGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRR 513
Query: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
+VS + D VK+WD + C+H+ H V + F G + + +D +++VWDV T
Sbjct: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETG 571
Query: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG---HQGPATT 238
+ H + +G+ N L++ ++DST+KI D+ G+ L TL G HQ T
Sbjct: 572 NCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
Query: 239 VAFSRTGEYFASGGSDEQVMVW 260
+ F++ + + D V +W
Sbjct: 630 LQFNK--NFVITSSDDGTVKLW 649
Score = 106 bits (264), Expect = 4e-23
Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 13/241 (5%)
Query: 21 GHKD-AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79
GH D +TC+ F G+ + SGS D T+++W HT V S +
Sbjct: 378 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 433
Query: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
++ S D+T+KVW + + +L H + VRC + +VS S D T+++WD +
Sbjct: 434 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 491
Query: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199
+C+H H V V + G + + D VKVWD T L Q H+ V L F
Sbjct: 492 QCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
Query: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
G ++++ S D+++++ D+ G ++TL GHQ + T SG +D V +
Sbjct: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKI 605
Query: 260 W 260
W
Sbjct: 606 W 606
Score = 79.7 bits (195), Expect = 4e-15
Identities = 51/188 (27%), Positives = 93/188 (49%), Gaps = 11/188 (5%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D+ L VW ++ + GH AV CV + G + SG+ D V++W P +
Sbjct: 480 DATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTL 537
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
+ HT V S+ F DG V+ S D +++VW + +L+ H + + + +
Sbjct: 538 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--I 593
Query: 122 IVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
+VS + D TVK+WD + +C+ + +H VT + F+ + + + D TVK+WD+
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
Query: 179 RTHRLLQH 186
+T +++
Sbjct: 652 KTGEFIRN 659
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 116 bits (291), Expect = 3e-26
Identities = 75/262 (28%), Positives = 123/262 (46%), Gaps = 15/262 (5%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D+ L VW GH V + ++ SGS D+T+++W
Sbjct: 320 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTL 377
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
HT+TVR +H + V+ S D T++VW + L L H+ VRC ++ DGR
Sbjct: 378 YGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRR 433
Query: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
+VS + D VK+WD + C+H+ H V + F G + + +D +++VWDV T
Sbjct: 434 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETG 491
Query: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG---HQGPATT 238
+ H + +G+ N L++ ++DST+KI D+ G+ L TL G HQ T
Sbjct: 492 NCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 549
Query: 239 VAFSRTGEYFASGGSDEQVMVW 260
+ F++ + + D V +W
Sbjct: 550 LQFNK--NFVITSSDDGTVKLW 569
Score = 106 bits (264), Expect = 4e-23
Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 13/241 (5%)
Query: 21 GHKD-AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79
GH D +TC+ F G+ + SGS D T+++W HT V S +
Sbjct: 298 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 353
Query: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
++ S D+T+KVW + + +L H + VRC + +VS S D T+++WD +
Sbjct: 354 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 411
Query: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199
+C+H H V V + G + + D VKVWD T L Q H+ V L F
Sbjct: 412 QCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 469
Query: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
G ++++ S D+++++ D+ G ++TL GHQ + T SG +D V +
Sbjct: 470 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKI 525
Query: 260 W 260
W
Sbjct: 526 W 526
Score = 79.7 bits (195), Expect = 4e-15
Identities = 51/188 (27%), Positives = 93/188 (49%), Gaps = 11/188 (5%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D+ L VW ++ + GH AV CV + G + SG+ D V++W P +
Sbjct: 400 DATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTL 457
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
+ HT V S+ F DG V+ S D +++VW + +L+ H + + + +
Sbjct: 458 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--I 513
Query: 122 IVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
+VS + D TVK+WD + +C+ + +H VT + F+ + + + D TVK+WD+
Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571
Query: 179 RTHRLLQH 186
+T +++
Sbjct: 572 KTGEFIRN 579
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 116 bits (291), Expect = 3e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)
Query: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 74
F H V V FSP LLA+G D+ V++W V GE F+ A + S+ F
Sbjct: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 375
Query: 75 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
S G + AS+D ++W + +L+ H V AKF D IVS S D+T+KLW
Sbjct: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
Query: 135 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 194
D S+ C+ + + D + C+ + D ++ WD+R+ +++ +L +
Sbjct: 436 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 491
Query: 195 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 250
L +P L++ S D LK++DL + T T V FS G Y A+
Sbjct: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 551
Query: 251 GGSDEQVMVWKSNFDIVDHGEVTKV 275
G ++ + +W V G+V KV
Sbjct: 552 GSAEGSLYIWS-----VLTGKVEKV 571
Score = 62.0 bits (149), Expect = 8e-10
Identities = 41/212 (19%), Positives = 99/212 (46%), Gaps = 9/212 (4%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D +W + + TGH V F + SGS D+T+++W +++ + +
Sbjct: 387 DFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW--DLRSKVCIK 444
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
+ + C++ Q ++ DK ++ W + + + + + + +P+
Sbjct: 445 TVFAGSSCNDIVCTE-QCVMSGHFDKKIRFWDIRSESIVREM-ELLGKITALDLNPERTE 502
Query: 122 IVSASDDKTVKLWDKSSRECVHSYC----EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
++S S D +K+ D + ++ + G T V F P G+ +AA + ++ +W
Sbjct: 503 LLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWS 562
Query: 178 VRTHRLLQHY-QLHSAAVNGLSFHPSGNYLIT 208
V T ++ + + HS+++N +++ PSG+++++
Sbjct: 563 VLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 594
Score = 31.6 bits (70), Expect = 1.2
Identities = 33/140 (23%), Positives = 53/140 (37%), Gaps = 10/140 (7%)
Query: 2 DSCLMVWHMKPQS--RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59
D + W ++ +S R G +T ++ +P L S SRD +++
Sbjct: 468 DKKIRFWDIRSESIVREMELLGK---ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQ 524
Query: 60 VFRAHTATVRS----VHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLS-QHINWVRCAK 114
F A S V F DG S + ++ +W+ K LS QH + +
Sbjct: 525 TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVA 584
Query: 115 FSPDGRLIVSASDDKTVKLW 134
+SP G +VS LW
Sbjct: 585 WSPSGSHVVSVDKGCKAVLW 604
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 116 bits (291), Expect = 3e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)
Query: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 74
F H V V FSP LLA+G D+ V++W V GE F+ A + S+ F
Sbjct: 299 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 356
Query: 75 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
S G + AS+D ++W + +L+ H V AKF D IVS S D+T+KLW
Sbjct: 357 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 416
Query: 135 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 194
D S+ C+ + + D + C+ + D ++ WD+R+ +++ +L +
Sbjct: 417 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 472
Query: 195 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 250
L +P L++ S D LK++DL + T T V FS G Y A+
Sbjct: 473 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 532
Query: 251 GGSDEQVMVWKSNFDIVDHGEVTKV 275
G ++ + +W V G+V KV
Sbjct: 533 GSAEGSLYIWS-----VLTGKVEKV 552
Score = 62.0 bits (149), Expect = 8e-10
Identities = 41/212 (19%), Positives = 99/212 (46%), Gaps = 9/212 (4%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
D +W + + TGH V F + SGS D+T+++W +++ + +
Sbjct: 368 DFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW--DLRSKVCIK 425
Query: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
+ + C++ Q ++ DK ++ W + + + + + + +P+
Sbjct: 426 TVFAGSSCNDIVCTE-QCVMSGHFDKKIRFWDIRSESIVREM-ELLGKITALDLNPERTE 483
Query: 122 IVSASDDKTVKLWDKSSRECVHSYC----EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
++S S D +K+ D + ++ + G T V F P G+ +AA + ++ +W
Sbjct: 484 LLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWS 543
Query: 178 VRTHRLLQHY-QLHSAAVNGLSFHPSGNYLIT 208
V T ++ + + HS+++N +++ PSG+++++
Sbjct: 544 VLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 575
Score = 31.6 bits (70), Expect = 1.2
Identities = 33/140 (23%), Positives = 53/140 (37%), Gaps = 10/140 (7%)
Query: 2 DSCLMVWHMKPQS--RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59
D + W ++ +S R G +T ++ +P L S SRD +++
Sbjct: 449 DKKIRFWDIRSESIVREMELLGK---ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQ 505
Query: 60 VFRAHTATVRS----VHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLS-QHINWVRCAK 114
F A S V F DG S + ++ +W+ K LS QH + +
Sbjct: 506 TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVA 565
Query: 115 FSPDGRLIVSASDDKTVKLW 134
+SP G +VS LW
Sbjct: 566 WSPSGSHVVSVDKGCKAVLW 585
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 113 bits (283), Expect = 2e-25
Identities = 81/306 (26%), Positives = 131/306 (42%), Gaps = 50/306 (16%)
Query: 5 LMVWHMKPQSRAYR-FTGHKDAVTCVNF-----SPSGHLLASGSRDKTVRIWVPNVKGES 58
+++W + R GH +T +++ +P +AS S+D +VRIW
Sbjct: 180 ILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCE 239
Query: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
+ HT +V + + DG + +AS D+T+KVW H +L H +WV S D
Sbjct: 240 RILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTD 298
Query: 119 GRL------------------------------------------IVSASDDKTVKLWDK 136
L +VS SDD T+ LW
Sbjct: 299 YALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSP 358
Query: 137 SS-RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195
+ ++ + H + V F P +A+A D ++K+WD RT + L + H AAV
Sbjct: 359 AEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 418
Query: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 255
+++ L++ SSDSTLK+ D+ +L L GH V +S G+ ASGG D+
Sbjct: 419 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478
Query: 256 QVMVWK 261
+ +W+
Sbjct: 479 CLRIWR 484
Score = 86.7 bits (213), Expect = 3e-17
Identities = 68/308 (22%), Positives = 122/308 (39%), Gaps = 50/308 (16%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNV-KGESTV 60
D+ + W + ++ + GH+ V +++SP G LASG ++ + +W P+ K
Sbjct: 135 DTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRT 194
Query: 61 FRAHTATV-----RSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF 115
H+ + +H + + ++S D +V++W T + L+ H V C ++
Sbjct: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRW 254
Query: 116 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYV-----------DFHPSGTCI 164
DG L+ SAS D+T+K+W + HG +V + F P+ +
Sbjct: 255 GGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASV 313
Query: 165 -------------------------------AAAGMDNTVKVWD-VRTHRLLQHYQLHSA 192
+ D T+ +W + L H A
Sbjct: 314 NPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQA 373
Query: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 252
+N + F P + +AS D ++K+ D G+ L +L GH +A+S SG
Sbjct: 374 LINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGS 433
Query: 253 SDEQVMVW 260
SD + VW
Sbjct: 434 SDSTLKVW 441
Score = 84.3 bits (207), Expect = 2e-16
Identities = 72/289 (24%), Positives = 115/289 (39%), Gaps = 50/289 (17%)
Query: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
GH +AV V FSP+G LASGS D TVR W + + + H V S+ + DG+
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
Query: 81 VTASDDKTVKVWATHRQKFL-FSLSQHINWVRCAKF-----SPDGRLIVSASDDKTVKLW 134
+ + + +W K + +L+ H W+ + +P+ R + S+S D +V++W
Sbjct: 172 ASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIW 231
Query: 135 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 194
D ++ C H VT + + G + +A D T+KVW L + Q H V
Sbjct: 232 DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWV 290
Query: 195 NGL-----------SFHPS-------------------------------GNYLITASSD 212
N + +F P+ L++ S D
Sbjct: 291 NTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDD 350
Query: 213 STLKILDLMEGRL-LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
TL + E + L + GHQ V FS AS D+ + +W
Sbjct: 351 FTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
Score = 82.8 bits (203), Expect = 4e-16
Identities = 42/134 (31%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 2 DSCLMVWHMKPQSRAY-RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
D L +W + R TGH+ + V FSP ++AS S DK++++W
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
R H A V + + +D + V+ S D T+KVW QK L H + V +SPDG+
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ 469
Query: 121 LIVSASDDKTVKLW 134
+ S DK +++W
Sbjct: 470 RVASGGKDKCLRIW 483
Score = 71.6 bits (174), Expect = 1e-12
Identities = 49/169 (28%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPS 160
SL H V FSP G+ + S S D TV+ WD S+ E H C+ H +V + + P
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST-ETPHFTCKGHRHWVLSISWSPD 167
Query: 161 GTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSF-----HPSGNYLITASSDST 214
G +A+ + + +WD T + + + HS + GLS+ +P Y+ ++S D +
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
Query: 215 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
++I D GR L GH T + + G + S D + VW+++
Sbjct: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAH 275
Score = 44.7 bits (104), Expect = 1e-04
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 6/126 (4%)
Query: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 200
C S H V V F P+G +A+ D TV+ WD+ T + H V +S+
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 201 PSGNYLITASSDSTLKILDLMEGRLL-YTLHGHQGPATTVAF-----SRTGEYFASGGSD 254
P G L + + + + D G+ + TL GH T +++ + Y AS D
Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 255 EQVMVW 260
V +W
Sbjct: 226 GSVRIW 231
Score = 36.6 bits (83), Expect = 0.037
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 224 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
R +L GH +VAFS TG+Y ASG D V W
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFW 141
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 112 bits (279), Expect = 7e-25
Identities = 80/252 (31%), Positives = 119/252 (47%), Gaps = 13/252 (5%)
Query: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH--TATVRSVHFCSDG 77
+GH+ AV+ +F L SGS D TV++W P V G H A V D
Sbjct: 99 SGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDP-VDGSVVRDFEHRPKAPVVECSITGDS 157
Query: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD-DKTVKLWDK 136
+ AS DKTV+ W K L+ + V C KFSPDG+ +VS D D + + D
Sbjct: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSGFDVDHGICIMDA 216
Query: 137 SSRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH-RLLQHYQLHSAAV 194
+ V + H +T F P +A+ +D +K+WDV + LL + HS A+
Sbjct: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
Query: 195 NGLSFHPSGNYLITASSDSTLKILDLMEGRL------LYTLHGHQGPATTVAFSRTGEYF 248
+ F SG++L T+S D LKI ++ G + + GH+G ++ F+R +
Sbjct: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFL 336
Query: 249 ASGGSDEQVMVW 260
SGG D V +W
Sbjct: 337 ISGGFDRTVAIW 348
Score = 79.3 bits (194), Expect = 5e-15
Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 7/142 (4%)
Query: 1 MDSCLMVWHMKPQSRAYRFT-GHKDAVTCVNFSPSGHLLASGSRDKTVRIW------VPN 53
+D C+ +W + Q+ T H +A++ F+ SGH L + S DK ++IW N
Sbjct: 250 LDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRN 309
Query: 54 VKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 113
T+ + H +V S HF D ++ D+TV +W SL H +WV
Sbjct: 310 CGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV 369
Query: 114 KFSPDGRLIVSASDDKTVKLWD 135
S + + I+SAS D+T++LW+
Sbjct: 370 AISNNKKWILSASKDRTMRLWN 391
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 111 bits (278), Expect = 9e-25
Identities = 79/260 (30%), Positives = 123/260 (47%), Gaps = 7/260 (2%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTV 60
D ++V+ + GH VT V F PS L+ S S D T+RIW VPN V
Sbjct: 243 DKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVV 302
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW--VRCAKFSPD 118
RAH + V + + G +++SDD+ + L ++ + + CA+F PD
Sbjct: 303 -RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD 361
Query: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
G + + + D +K+WD R V ++ H G +T + F +G +A A D++VK+WD+
Sbjct: 362 GLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421
Query: 179 RTHRLLQHYQL-HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
R + + QL ++ V L F SG YL +D + I L +T H G T
Sbjct: 422 RKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFT--EHSGLTT 479
Query: 238 TVAFSRTGEYFASGGSDEQV 257
VAF ++ AS G D +
Sbjct: 480 GVAFGHHAKFIASTGMDRSL 499
Score = 100 bits (249), Expect = 2e-21
Identities = 58/188 (30%), Positives = 86/188 (45%), Gaps = 2/188 (1%)
Query: 75 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
SD +T DK V V+ ++ L +L H V F P L+ SAS D T+++W
Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
Query: 135 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--QLHSA 192
+ CV H VT + H +G + ++ D D++T R+L +
Sbjct: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
Query: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 252
++ FHP G T + DS +KI DL E + GH GP T++AFS G Y A+
Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
Query: 253 SDEQVMVW 260
D V +W
Sbjct: 412 DDSSVKLW 419
Score = 97.1 bits (240), Expect = 2e-20
Identities = 60/242 (24%), Positives = 111/242 (45%), Gaps = 6/242 (2%)
Query: 38 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 97
+ +G DK V ++ + + + HT V SV F +AS D T+++W+
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
Query: 98 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH--GGFVTYV 155
+ + H + V G ++S+SDD+ D + + + G +T
Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
Query: 156 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 215
FHP G MD+ +K+WD++ + ++ HS + ++F +G YL TA+ DS++
Sbjct: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSV 416
Query: 216 KILDLMEGRLLYTLH-GHQGPATTVAFSRTGEYFASGGSDEQVMV---WKSNFDIVDHGE 271
K+ DL + + TL + ++ F ++G Y A GG+D Q+ + W +H
Sbjct: 417 KLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSG 476
Query: 272 VT 273
+T
Sbjct: 477 LT 478
Score = 72.0 bits (175), Expect = 8e-13
Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 3/155 (1%)
Query: 25 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 84
++TC F P G + +G+ D ++IW + F H+ + S+ F +G TA+
Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
Query: 85 DDKTVKVWATHRQKFLFSLSQHINW-VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 143
DD +VK+W + K +L N+ V+ F G + D + + K E +H
Sbjct: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYIC-KQWTEILH 470
Query: 144 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
+ EH G T V F IA+ GMD ++K + +
Sbjct: 471 -FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
Score = 55.5 bits (132), Expect = 8e-08
Identities = 31/135 (22%), Positives = 63/135 (46%), Gaps = 3/135 (2%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGEST 59
MDS + +W +K ++ F GH +T + FS +G+ LA+ + D +V++W + +K T
Sbjct: 370 MDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKT 429
Query: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
+ + V+S+ F G D V+++ + + ++H F
Sbjct: 430 LQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHA 487
Query: 120 RLIVSASDDKTVKLW 134
+ I S D+++K +
Sbjct: 488 KFIASTGMDRSLKFY 502
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 111 bits (278), Expect = 9e-25
Identities = 85/322 (26%), Positives = 133/322 (41%), Gaps = 65/322 (20%)
Query: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK---GESTVFRAH---- 64
P ++A GH+ V ++P LLASGS D T RIW N G + + H
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 65 -------TATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117
V S+ + SDG S D ++W T +L QH + K++
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNK 286
Query: 118 DGRLIVSASDDKTVKLWDKSSRE------------------------------CVH---- 143
G ++SA DKT +WD + E C+H
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 144 -------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196
++ H V + + PSG +A+ D T+K+W ++ + Q HS +
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 197 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 247
+ + P+G L +AS DST+++ D+ +G +TL HQ P +VAFS G+Y
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 248 FASGGSDEQVMVWKSNFDIVDH 269
ASG D+ V +W + + H
Sbjct: 467 LASGSFDKYVHIWNTQSGSLVH 488
Score = 102 bits (255), Expect = 4e-22
Identities = 68/251 (27%), Positives = 111/251 (44%), Gaps = 19/251 (7%)
Query: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
HK + + ++ G+ + S DKT IW + F H+A V + + +F
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFA 333
Query: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141
+ S D + V + + H N V K+ P G L+ S SDD T+K+W C
Sbjct: 334 SCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDAC 393
Query: 142 VHSYCEHGGFVTYVDFHPSGTC---------IAAAGMDNTVKVWDVR----THRLLQHYQ 188
VH H + + + P+G +A+A D+TV++WDV TH L++H +
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE 453
Query: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248
V ++F P G YL + S D + I + G L+++ G G V ++ G+
Sbjct: 454 ----PVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKV 508
Query: 249 ASGGSDEQVMV 259
+ SD V V
Sbjct: 509 GASASDGSVCV 519
Score = 87.4 bits (215), Expect = 2e-17
Identities = 56/229 (24%), Positives = 101/229 (44%), Gaps = 11/229 (4%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
+D ++W +F H V++ + AS S D + +
Sbjct: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
F+ HT V ++ + G + SDD T+K+W+ + + L H + K+SP G
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGP 414
Query: 121 ---------LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171
++ SAS D TV+LWD C H+ +H V V F P G +A+ D
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDK 474
Query: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220
V +W+ ++ L+ YQ + + + ++ G+ + ++SD ++ +LDL
Sbjct: 475 YVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 111 bits (278), Expect = 9e-25
Identities = 85/322 (26%), Positives = 133/322 (41%), Gaps = 65/322 (20%)
Query: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK---GESTVFRAH---- 64
P ++A GH+ V ++P LLASGS D T RIW N G + + H
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 65 -------TATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117
V S+ + SDG S D ++W T +L QH + K++
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNK 286
Query: 118 DGRLIVSASDDKTVKLWDKSSRE------------------------------CVH---- 143
G ++SA DKT +WD + E C+H
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 144 -------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196
++ H V + + PSG +A+ D T+K+W ++ + Q HS +
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 197 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 247
+ + P+G L +AS DST+++ D+ +G +TL HQ P +VAFS G+Y
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 248 FASGGSDEQVMVWKSNFDIVDH 269
ASG D+ V +W + + H
Sbjct: 467 LASGSFDKYVHIWNTQSGSLVH 488
Score = 102 bits (255), Expect = 4e-22
Identities = 68/251 (27%), Positives = 111/251 (44%), Gaps = 19/251 (7%)
Query: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
HK + + ++ G+ + S DKT IW + F H+A V + + +F
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFA 333
Query: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141
+ S D + V + + H N V K+ P G L+ S SDD T+K+W C
Sbjct: 334 SCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDAC 393
Query: 142 VHSYCEHGGFVTYVDFHPSGTC---------IAAAGMDNTVKVWDVR----THRLLQHYQ 188
VH H + + + P+G +A+A D+TV++WDV TH L++H +
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE 453
Query: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248
V ++F P G YL + S D + I + G L+++ G G V ++ G+
Sbjct: 454 ----PVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKV 508
Query: 249 ASGGSDEQVMV 259
+ SD V V
Sbjct: 509 GASASDGSVCV 519
Score = 87.4 bits (215), Expect = 2e-17
Identities = 56/229 (24%), Positives = 101/229 (44%), Gaps = 11/229 (4%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
+D ++W +F H V++ + AS S D + +
Sbjct: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
F+ HT V ++ + G + SDD T+K+W+ + + L H + K+SP G
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGP 414
Query: 121 ---------LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171
++ SAS D TV+LWD C H+ +H V V F P G +A+ D
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDK 474
Query: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220
V +W+ ++ L+ YQ + + + ++ G+ + ++SD ++ +LDL
Sbjct: 475 YVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 111 bits (278), Expect = 9e-25
Identities = 85/322 (26%), Positives = 133/322 (41%), Gaps = 65/322 (20%)
Query: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK---GESTVFRAH---- 64
P ++A GH+ V ++P LLASGS D T RIW N G + + H
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 65 -------TATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117
V S+ + SDG S D ++W T +L QH + K++
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNK 286
Query: 118 DGRLIVSASDDKTVKLWDKSSRE------------------------------CVH---- 143
G ++SA DKT +WD + E C+H
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 144 -------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196
++ H V + + PSG +A+ D T+K+W ++ + Q HS +
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 197 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 247
+ + P+G L +AS DST+++ D+ +G +TL HQ P +VAFS G+Y
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 248 FASGGSDEQVMVWKSNFDIVDH 269
ASG D+ V +W + + H
Sbjct: 467 LASGSFDKYVHIWNTQSGSLVH 488
Score = 102 bits (255), Expect = 4e-22
Identities = 68/251 (27%), Positives = 111/251 (44%), Gaps = 19/251 (7%)
Query: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
HK + + ++ G+ + S DKT IW + F H+A V + + +F
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFA 333
Query: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141
+ S D + V + + H N V K+ P G L+ S SDD T+K+W C
Sbjct: 334 SCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDAC 393
Query: 142 VHSYCEHGGFVTYVDFHPSGTC---------IAAAGMDNTVKVWDVR----THRLLQHYQ 188
VH H + + + P+G +A+A D+TV++WDV TH L++H +
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE 453
Query: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248
V ++F P G YL + S D + I + G L+++ G G V ++ G+
Sbjct: 454 ----PVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKV 508
Query: 249 ASGGSDEQVMV 259
+ SD V V
Sbjct: 509 GASASDGSVCV 519
Score = 87.4 bits (215), Expect = 2e-17
Identities = 56/229 (24%), Positives = 101/229 (44%), Gaps = 11/229 (4%)
Query: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
+D ++W +F H V++ + AS S D + +
Sbjct: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
F+ HT V ++ + G + SDD T+K+W+ + + L H + K+SP G
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGP 414
Query: 121 ---------LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171
++ SAS D TV+LWD C H+ +H V V F P G +A+ D
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDK 474
Query: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220
V +W+ ++ L+ YQ + + + ++ G+ + ++SD ++ +LDL
Sbjct: 475 YVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]
Length = 919
Score = 110 bits (276), Expect = 2e-24
Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)
Query: 11 KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 65
+P R R HK ++ CV +SP G LLA+GS DK V++ N G F H
Sbjct: 649 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 708
Query: 66 ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
T+R + F S G ++A + D + R + L +LS H + A ++ G
Sbjct: 709 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 767
Query: 121 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
+I S S DKTV+ WD CV ++ G V V PSG +A D++ ++
Sbjct: 768 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 827
Query: 177 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 231
D+R R++Q Y HS+ V + F P +YL+T S D +K+ DL +G L + +
Sbjct: 828 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 886
Query: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
H+ + F S +D V +W N
Sbjct: 887 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 918
Score = 80.5 bits (197), Expect = 2e-15
Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 25 AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 71
AV V F P+G L A GS KT+R+ P+V S V R H ++ V
Sbjct: 608 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 667
Query: 72 HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 122
+ GQ T S+DK VKV + + S H +R F G ++
Sbjct: 668 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 727
Query: 123 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
+SA + D + D + +H+ H G + + + SG IA+ D TV+ WD+R
Sbjct: 728 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 786
Query: 182 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
++ + +AV ++ PSG L T DS+ + D+ GR++ + H H
Sbjct: 787 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 846
Query: 238 TVAFSRTGEYFASGGSDEQVMV 259
+V FS Y +G D ++ V
Sbjct: 847 SVRFSPGAHYLLTGSYDMKIKV 868
Score = 42.0 bits (97), Expect = 9e-04
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-- 59
DS M++ ++ + H V V FSP H L +GS D ++I V +++G+ T
Sbjct: 821 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYD--MKIKVTDLQGDLTKQ 878
Query: 60 ----VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 92
V H V + + SF+++S D+TV +W
Sbjct: 879 LPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 915
>gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
Length = 927
Score = 110 bits (276), Expect = 2e-24
Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)
Query: 11 KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 65
+P R R HK ++ CV +SP G LLA+GS DK V++ N G F H
Sbjct: 657 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 716
Query: 66 ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
T+R + F S G ++A + D + R + L +LS H + A ++ G
Sbjct: 717 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 775
Query: 121 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
+I S S DKTV+ WD CV ++ G V V PSG +A D++ ++
Sbjct: 776 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 835
Query: 177 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 231
D+R R++Q Y HS+ V + F P +YL+T S D +K+ DL +G L + +
Sbjct: 836 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 894
Query: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
H+ + F S +D V +W N
Sbjct: 895 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 926
Score = 80.5 bits (197), Expect = 2e-15
Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 25 AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 71
AV V F P+G L A GS KT+R+ P+V S V R H ++ V
Sbjct: 616 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 675
Query: 72 HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 122
+ GQ T S+DK VKV + + S H +R F G ++
Sbjct: 676 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 735
Query: 123 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
+SA + D + D + +H+ H G + + + SG IA+ D TV+ WD+R
Sbjct: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 794
Query: 182 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
++ + +AV ++ PSG L T DS+ + D+ GR++ + H H
Sbjct: 795 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 854
Query: 238 TVAFSRTGEYFASGGSDEQVMV 259
+V FS Y +G D ++ V
Sbjct: 855 SVRFSPGAHYLLTGSYDMKIKV 876
Score = 42.0 bits (97), Expect = 9e-04
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-- 59
DS M++ ++ + H V V FSP H L +GS D ++I V +++G+ T
Sbjct: 829 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYD--MKIKVTDLQGDLTKQ 886
Query: 60 ----VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 92
V H V + + SF+++S D+TV +W
Sbjct: 887 LPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
>gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
Length = 920
Score = 110 bits (276), Expect = 2e-24
Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)
Query: 11 KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 65
+P R R HK ++ CV +SP G LLA+GS DK V++ N G F H
Sbjct: 650 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 709
Query: 66 ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
T+R + F S G ++A + D + R + L +LS H + A ++ G
Sbjct: 710 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 768
Query: 121 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
+I S S DKTV+ WD CV ++ G V V PSG +A D++ ++
Sbjct: 769 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 828
Query: 177 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 231
D+R R++Q Y HS+ V + F P +YL+T S D +K+ DL +G L + +
Sbjct: 829 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 887
Query: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
H+ + F S +D V +W N
Sbjct: 888 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 919
Score = 80.5 bits (197), Expect = 2e-15
Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 25 AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 71
AV V F P+G L A GS KT+R+ P+V S V R H ++ V
Sbjct: 609 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 668
Query: 72 HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 122
+ GQ T S+DK VKV + + S H +R F G ++
Sbjct: 669 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 728
Query: 123 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
+SA + D + D + +H+ H G + + + SG IA+ D TV+ WD+R
Sbjct: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 787
Query: 182 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
++ + +AV ++ PSG L T DS+ + D+ GR++ + H H
Sbjct: 788 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 847
Query: 238 TVAFSRTGEYFASGGSDEQVMV 259
+V FS Y +G D ++ V
Sbjct: 848 SVRFSPGAHYLLTGSYDMKIKV 869
Score = 42.0 bits (97), Expect = 9e-04
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-- 59
DS M++ ++ + H V V FSP H L +GS D ++I V +++G+ T
Sbjct: 822 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYD--MKIKVTDLQGDLTKQ 879
Query: 60 ----VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 92
V H V + + SF+++S D+TV +W
Sbjct: 880 LPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 110 bits (274), Expect = 3e-24
Identities = 68/273 (24%), Positives = 119/273 (43%), Gaps = 30/273 (10%)
Query: 18 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 77
+F V ++F P + + + +++W + F H VR + F
Sbjct: 4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ 63
Query: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
FV+ DD +KVW ++ LF+L H++++R F + I+SASDD+T+++W+
Sbjct: 64 PLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
Query: 138 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV------------------- 178
SR CV H +V FHP+ + +A +D TV+VWD+
Sbjct: 124 SRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRG 183
Query: 179 --------RTHRLLQH-YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL--LY 227
T +++H + H VN +FHP+ +++ + D +KI + E + +
Sbjct: 184 ITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVD 243
Query: 228 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
T GH + F E S D+ + VW
Sbjct: 244 TCRGHYNNVSCAVFHPRQELILSNSEDKSIRVW 276
Score = 81.3 bits (199), Expect = 1e-15
Identities = 64/234 (27%), Positives = 104/234 (44%), Gaps = 19/234 (8%)
Query: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTV 60
D + VW+ + ++ TGH V C F P+ L+ S S D+TVR+W + ++ ++
Sbjct: 114 DQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLS 173
Query: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
A + VR + G +D V H + +NW A F P
Sbjct: 174 PGAVESDVRGI----TGVDLFGTTDAVVKHVLEGH--------DRGVNW---AAFHPTMP 218
Query: 121 LIVSASDDKTVKLW--DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
LIVS +DD+ VK+W ++S V + H V+ FHP I + D +++VWD+
Sbjct: 219 LIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
Query: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 232
+Q ++ L+ HP+ N L A D + + L R Y +HG+
Sbjct: 279 SKRTGVQTFRRDHDRFWVLAAHPNLN-LFAAGHDGGMIVFKLERERPAYAVHGN 331
Score = 78.2 bits (191), Expect = 1e-14
Identities = 52/233 (22%), Positives = 92/233 (39%), Gaps = 28/233 (12%)
Query: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
T F +A V+ + F +T+ + +++W + +H VR F
Sbjct: 3 TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQ 62
Query: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
L VS DD +K+W+ R C+ + H ++ FH I +A D T++VW+
Sbjct: 63 QPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNW 122
Query: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL------------------ 220
++ + H+ V FHP+ + +++AS D T+++ D+
Sbjct: 123 QSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVR 182
Query: 221 ----------MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
+ + + L GH AF T SG D QV +W+ N
Sbjct: 183 GITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
Score = 52.4 bits (124), Expect = 7e-07
Identities = 24/78 (30%), Positives = 40/78 (51%)
Query: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
+L ++ SA V GLSFHP +++T+ + +++ D L+ H GP + F
Sbjct: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
Query: 243 RTGEYFASGGSDEQVMVW 260
+ F SGG D ++ VW
Sbjct: 61 KQQPLFVSGGDDYKIKVW 78
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.131 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,261,445
Number of Sequences: 37866
Number of extensions: 693394
Number of successful extensions: 6420
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 2271
Number of HSP's gapped (non-prelim): 1801
length of query: 369
length of database: 18,247,518
effective HSP length: 104
effective length of query: 265
effective length of database: 14,309,454
effective search space: 3792005310
effective search space used: 3792005310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.