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Search of human proteins with 239787760
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
(359 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 741 0.0
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 718 0.0
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 640 0.0
gi|26665869 WD repeat domain 51B [Homo sapiens] 424 e-119
gi|32189425 WD repeat domain 69 [Homo sapiens] 162 4e-40
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 157 1e-38
gi|23199987 WD repeat domain 5B [Homo sapiens] 156 3e-38
gi|16554629 WD repeat domain 5 [Homo sapiens] 136 3e-32
gi|16554627 WD repeat domain 5 [Homo sapiens] 136 3e-32
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 132 5e-31
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 130 1e-30
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 130 1e-30
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 130 1e-30
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 130 2e-30
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 129 5e-30
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 128 9e-30
gi|21071067 TBP-associated factor 5 [Homo sapiens] 126 3e-29
gi|113865883 WD repeat domain 38 [Homo sapiens] 125 4e-29
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 125 8e-29
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 125 8e-29
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 117 2e-26
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 117 2e-26
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 116 3e-26
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 116 3e-26
gi|19913367 transducin beta-like 1Y [Homo sapiens] 116 3e-26
gi|19913365 transducin beta-like 1Y [Homo sapiens] 116 3e-26
gi|15150805 transducin beta-like 1Y [Homo sapiens] 116 3e-26
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 115 8e-26
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 115 8e-26
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 115 8e-26
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 741 bits (1912), Expect = 0.0
Identities = 359/359 (100%), Positives = 359/359 (100%)
Query: 1 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH 60
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH
Sbjct: 1 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH 60
Query: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
Query: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Query: 301 NFDIVDHGEVTKVPRPPATLASSMGNLTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 359
NFDIVDHGEVTKVPRPPATLASSMGNLTVSILEQRLTLTEDKLKQCLENQQLIMQRATP
Sbjct: 301 NFDIVDHGEVTKVPRPPATLASSMGNLTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 359
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 718 bits (1853), Expect = 0.0
Identities = 359/407 (88%), Positives = 359/407 (88%), Gaps = 48/407 (11%)
Query: 1 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH 60
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH
Sbjct: 1 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH 60
Query: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
Query: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Query: 301 NFDIVDHGEVTKVPRPPATLASSMGNL--------------------------------- 327
NFDIVDHGEVTKVPRPPATLASSMGNL
Sbjct: 301 NFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLT 360
Query: 328 ---------------TVSILEQRLTLTEDKLKQCLENQQLIMQRATP 359
TVSILEQRLTLTEDKLKQCLENQQLIMQRATP
Sbjct: 361 STLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 407
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 640 bits (1651), Expect = 0.0
Identities = 321/369 (86%), Positives = 321/369 (86%), Gaps = 48/369 (13%)
Query: 39 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 98
MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218
LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
Query: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
Query: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNL----------- 327
FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNL
Sbjct: 241 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGR 300
Query: 328 -------------------------------------TVSILEQRLTLTEDKLKQCLENQ 350
TVSILEQRLTLTEDKLKQCLENQ
Sbjct: 301 GRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQ 360
Query: 351 QLIMQRATP 359
QLIMQRATP
Sbjct: 361 QLIMQRATP 369
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/102 (31%), Positives = 45/102 (44%), Gaps = 4/102 (3%)
Query: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
L +H++ H AV + F + L + S DS L + + Y GH+ T V FS
Sbjct: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
Query: 71 PSGHLLASGSRDKTVRIWVPNV----KGESTVFRAHTATVRS 108
+G ASG D+ V +W N GE T AT+ S
Sbjct: 243 RTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLAS 284
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 424 bits (1089), Expect = e-119
Identities = 194/310 (62%), Positives = 252/310 (81%)
Query: 3 APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62
A EDP LER+FKGH+ A+T +D S N KQLA+ S D+ LM+W+ KP +RAYR+ GHKD
Sbjct: 2 ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD 61
Query: 63 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122
VT V FSP G+LLAS SRD+TVR+W+P+ +G+ + F+AHTA VRSV F +DGQ TAS
Sbjct: 62 VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121
Query: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
+DK++KVW+ +RQ+FL+SL +H +WVRCAKFSPDGRLIVS S+DKT+K+WD ++++CV++
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
+ + GF +VDF+PSGTCIA+AG D TVKVWDVR ++LLQHYQ+HS VN +SFHPSGN
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
Query: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302
YLITASSD TLKILDL+EGRL+YTL GH GP TV+FS+ GE FASGG+D QV++W++NF
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301
Query: 303 DIVDHGEVTK 312
D + +TK
Sbjct: 302 DELHCKGLTK 311
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 162 bits (410), Expect = 4e-40
Identities = 88/285 (30%), Positives = 143/285 (50%), Gaps = 1/285 (0%)
Query: 16 KGHRDAVTCVDFSINT-KQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
+GHR+ V + F+ ++A+GS D +W ++ + F GH + C++F+P
Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190
Query: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
L+A+GS D T ++W E R H+A + S+ F + G +T S D TV VW
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
+ + L H + A F+ D LI++ S DKT KLWD ++ +CV + H +
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
F +G IA A D T +++ T + + + H ++ +SF+P GN+L+T SSD T +
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
Query: 255 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
I D G+ L L GH + AF+ G +G D +W+
Sbjct: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 139 bits (351), Expect = 3e-33
Identities = 70/241 (29%), Positives = 126/241 (52%)
Query: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
F+GH + C+ F+ + +A+GSMD+ +W ++ Y GH + ++F+ SG
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
+ +GS D TV +W + + + H A + S F D +T S DKT K+W
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
K + +L+ H + + + F G+LI +AS D T +++ ++R+C+ H G ++ +
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
F+P G + D T ++WD +T + LQ + H+ + +F+ GN +IT S D+T +
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
Query: 255 I 255
I
Sbjct: 413 I 413
Score = 117 bits (292), Expect = 2e-26
Identities = 69/238 (28%), Positives = 108/238 (45%), Gaps = 1/238 (0%)
Query: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSFVTAS 122
+T V + SG +GS D+T ++W E H V ++ F + G T S
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
DKT K+W+ K + H + C F+P L+ + S D T KLWD + E V++
Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
Query: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
H + + F+ SG I D+TV VWD T R + H A ++ SF+ +
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
Query: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
++T S D T K+ D G+ + TL GH F TG+ A+ +D ++ +
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332
Score = 116 bits (291), Expect = 3e-26
Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 1/202 (0%)
Query: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF-SPD 156
V +AH + +V G F+T S D+T K+W T + L +L H N V F +P
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
Query: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
G I + S DKT KLW + +C H++ H + + F+P T +A MD T K+WD+
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 276
+ + + HSA + LSF+ SG+ +IT S D T+ + D GR + L GH ++
Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
Query: 277 VAFSRTGEYFASGGSDEQVMVW 298
+F+ +G D+ +W
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLW 288
Score = 96.7 bits (239), Expect = 3e-20
Identities = 59/198 (29%), Positives = 98/198 (49%), Gaps = 12/198 (6%)
Query: 116 QSFVTASDDKTVKVWATHRQK----------FLFS-LSQHINWVRCAKFSPDGRLIVSAS 164
+ +TAS + VK+ Q+ +LF L HI + + G ++ S
Sbjct: 52 EPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGS 111
Query: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQ 223
D+T KLWD +S E +++ H V + F+ P G IA D T K+W V T +
Sbjct: 112 YDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYH 171
Query: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
++ H+A + LSF+P + T S D+T K+ D+ G +YTL GH +++F+ +G
Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSG 231
Query: 284 EYFASGGSDEQVMVWKSN 301
+ +G D V+VW ++
Sbjct: 232 DRIITGSFDHTVVVWDAD 249
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 157 bits (397), Expect = 1e-38
Identities = 93/305 (30%), Positives = 145/305 (47%), Gaps = 24/305 (7%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
GHR VT V F + S S D+ + VW + GH D+V ++F SG LL
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
Query: 77 ASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
AS S D T+++W + +G + H V SV +G V+AS DKT+K+W
Sbjct: 166 ASCSADMTIKLW--DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
+ + + H WVR + + DG LI S S+D+TV++W +++EC EH V +
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECIS 283
Query: 195 FHPS--------------------GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
+ P G + + D T+K+WDV T L H V G
Sbjct: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 343
Query: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294
+ FH G ++++ + D TL++ D R + TL+ H+ T++ F +T Y +G D+
Sbjct: 344 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQT 403
Query: 295 VMVWK 299
V VW+
Sbjct: 404 VKVWE 408
Score = 141 bits (355), Expect = 1e-33
Identities = 82/269 (30%), Positives = 124/269 (46%), Gaps = 20/269 (7%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
E ER KGH D+V + F + K LAS S D + +W + GH V+
Sbjct: 138 ETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSS 197
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
V P+G + S SRDKT+++W F H VR V DG + S+D+T
Sbjct: 198 VAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQT 257
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--------------------GRLIVSASDD 166
V+VW ++ L +H + V C ++P+ G ++S S D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317
Query: 167 KTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 226
KT+K+WD S+ C+ + H +V V FH G I + D T++VWD + R ++
Sbjct: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377
Query: 227 LHSAAVNGLSFHPSGNYLITASSDSTLKI 255
H V L FH + Y++T S D T+K+
Sbjct: 378 AHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 130 bits (327), Expect = 2e-30
Identities = 79/273 (28%), Positives = 125/273 (45%), Gaps = 21/273 (7%)
Query: 46 WHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT 105
W +P + Y +GH+ VT V F P ++ S S D T+++W + HT +
Sbjct: 94 WIPRPPEK-YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152
Query: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
V+ + F G+ + S D T+K+W + + ++ H + V P+G IVSAS
Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
Query: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
DKT+K+W+ + CV ++ H +V V + GT IA+ D TV+VW V T
Sbjct: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
Query: 226 QLHSAAVNGLSFHPSGNY--------------------LITASSDSTLKILDLMEGRLLY 265
+ H V +S+ P +Y L++ S D T+K+ D+ G L
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
Query: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
TL GH V F G++ S D+ + VW
Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 125 bits (313), Expect = 8e-29
Identities = 70/225 (31%), Positives = 105/225 (46%), Gaps = 20/225 (8%)
Query: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
R GH V+ V N + S S D + +W ++ FTGH++ V V +
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245
Query: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD------------------ 114
G L+AS S D+TVR+WV K R H V + + +
Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
Query: 115 --GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
G ++ S DKT+K+W L +L H NWVR F G+ I+S +DDKT+++W
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Query: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
D ++ C+ + H FVT +DFH + + +D TVKVW+ R
Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 75.5 bits (184), Expect = 7e-14
Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 7/148 (4%)
Query: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 245
H VT V FHP + + +A D T+KVWD T + + H+ +V +SF SG L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF--- 302
+ S+D T+K+ D + T+HGH ++VA G++ S D+ + +W+
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
Query: 303 --DIVDHGEVTKVPRP--PATLASSMGN 326
H E ++ RP TL +S N
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSN 254
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 156 bits (394), Expect = 3e-38
Identities = 89/245 (36%), Positives = 136/245 (55%), Gaps = 6/245 (2%)
Query: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 117
GH +AV+ V FSP+G LAS S D+ + IW + K E T++ H + V + SD
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSR 97
Query: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
V+ASDDKT+K+W K L +L H N+V C F+P LI+S S D+TVK+W+ +
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLS 236
+C+ + H V+ V F+ SG+ I + D ++WD + + L+ + V+ +
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
Query: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYFASGGSDE 293
F P+G Y++TA+ D+TLK+ D GR L T GH+ + FS T G++ SG D
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
Query: 294 QVMVW 298
V +W
Sbjct: 278 LVYIW 282
Score = 130 bits (326), Expect = 2e-30
Identities = 86/291 (29%), Positives = 138/291 (47%), Gaps = 6/291 (2%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
GH +AV+ V FS N + LAS S D +++W GH ++ V +S L
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
Query: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
S S DKT+++W + H+ V +F ++ S D+TVK+W K
Sbjct: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158
Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG-FVTYVDF 195
L +LS H + V F+ G LIVS S D ++WD +S +C+ + + V++V F
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 196 HPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS---GNYLITASSDST 252
P+G I A +DNT+K+WD R L+ Y H + + S G ++++ S D+
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278
Query: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMVWKSN 301
+ I +L ++ L GH + A T AS +D+ + +W SN
Sbjct: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
Score = 130 bits (326), Expect = 2e-30
Identities = 80/256 (31%), Positives = 130/256 (50%), Gaps = 6/256 (2%)
Query: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
A D E+ GH ++ V +S ++ +L S S D L +W ++ GH + V
Sbjct: 70 AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129
Query: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
C NF+P +L+ SGS D+TV+IW AH+ V +VHF G V+ S D
Sbjct: 130 CCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG 189
Query: 126 TVKVWATHRQKFLFSLSQHIN-WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184
++W + L +L N V KFSP+G+ I++A+ D T+KLWD S C+ +Y
Sbjct: 190 LCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249
Query: 185 EHGG--FVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
H + + +F G I + DN V +W+++T ++Q Q H+ V + HP+
Sbjct: 250 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTE 309
Query: 242 NYLITAS--SDSTLKI 255
N + +A+ +D T+K+
Sbjct: 310 NLIASAALENDKTIKL 325
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/159 (30%), Positives = 81/159 (50%)
Query: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 199
+L H V KFSP+G + S+S D+ + +W + + H ++ V +
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259
+ + +A D T+K+WDVR+ + L+ + HS V +F+P N +I+ S D T+KI ++
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 260 EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
G+ L TL H P + V F+ +G SG D +W
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 61.6 bits (148), Expect = 1e-09
Identities = 34/142 (23%), Positives = 69/142 (48%)
Query: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
+L +S+S +++ ++ + + + H V+ V F P+G +A++ D + +W
Sbjct: 12 QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY 71
Query: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
+ + H+ ++ +++ + L++AS D TLK+ D+ G+ L TL GH
Sbjct: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
Query: 278 AFSRTGEYFASGGSDEQVMVWK 299
F+ SG DE V +W+
Sbjct: 132 NFNPPSNLIISGSFDETVKIWE 153
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 136 bits (342), Expect = 3e-32
Identities = 90/304 (29%), Positives = 149/304 (49%), Gaps = 6/304 (1%)
Query: 4 PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63
P + +L+ GH AV+ V FS N + LAS S D + +W +GHK
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89
Query: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
++ V +S +LL S S DKT++IW + + H+ V +F V+ S
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
D++V++W K L +L H + V F+ DG LIVS+S D ++WD +S +C+ +
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 184 CEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-- 240
+ V++V F P+G I AA +DNT+K+WD + L+ Y H + + S
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 241 -GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMV 297
G ++++ S D+ + I +L ++ L GH + A T AS +D+ + +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329
Query: 298 WKSN 301
WKS+
Sbjct: 330 WKSD 333
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 136 bits (342), Expect = 3e-32
Identities = 90/304 (29%), Positives = 149/304 (49%), Gaps = 6/304 (1%)
Query: 4 PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63
P + +L+ GH AV+ V FS N + LAS S D + +W +GHK
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89
Query: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
++ V +S +LL S S DKT++IW + + H+ V +F V+ S
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
D++V++W K L +L H + V F+ DG LIVS+S D ++WD +S +C+ +
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 184 CEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-- 240
+ V++V F P+G I AA +DNT+K+WD + L+ Y H + + S
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 241 -GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMV 297
G ++++ S D+ + I +L ++ L GH + A T AS +D+ + +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329
Query: 298 WKSN 301
WKS+
Sbjct: 330 WKSD 333
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 132 bits (332), Expect = 5e-31
Identities = 91/297 (30%), Positives = 137/297 (46%), Gaps = 3/297 (1%)
Query: 3 APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62
+P D L+ F+ H V+CV + L S D V + + GH D
Sbjct: 336 SPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTD 395
Query: 63 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQSFVTA 121
++ F PSG LA+ S D TV++W KG+ + F H+ V S + S G ++
Sbjct: 396 WLSDCCFHPSGDKLATSSGDTTVKLW-DLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454
Query: 122 SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181
S DKT K+W + ++ +L H + V +F P ++++S DKT+ +WD + C
Sbjct: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514
Query: 182 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
S H + F P G IA+ K+WD R + + + N ++F SG
Sbjct: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSG 574
Query: 242 NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
L AS + + +LDL G ++ L GH+ A TV FS GE SGGSD V W
Sbjct: 575 RVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 76.6 bits (187), Expect = 3e-14
Identities = 42/159 (26%), Positives = 76/159 (47%)
Query: 148 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 207
V C P ++VS +D+ K+ + + H +++ FHPSG +A +
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 208 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
D TVK+WD+ + ++ HS AV ++H GN++ ++S D T KI D+ R TL
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
Query: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306
+GH ++ F + +D+ + +W + I +
Sbjct: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513
Score = 41.2 bits (95), Expect = 0.001
Identities = 32/156 (20%), Positives = 51/156 (32%), Gaps = 41/156 (26%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
GH D+V ++F + L + S D L +W + GH ++ F P GH++
Sbjct: 476 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 535
Query: 77 ASGSRDKTVRIW-----VPNVK------------------------------------GE 95
AS ++W +P V GE
Sbjct: 536 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE 595
Query: 96 STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
H +V F DG+ + D TV+ W+
Sbjct: 596 IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 130 bits (328), Expect = 1e-30
Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)
Query: 16 KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
KGH D +TC+ F N ++ SGS D+ L VW GH V +
Sbjct: 259 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 314
Query: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
++ SGS D+T+++W HT+TVR +H + V+ S D T++VW
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 372
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
+ L L H+ VRC ++ DGR +VS + D VK+WD + C+H+ H V +
Sbjct: 373 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 430
Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
F G + + +D +++VWDV T + H + +G+ N L++ ++DST+K
Sbjct: 431 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 486
Query: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298
I D+ G+ L TL G HQ T + F++ + + D V +W
Sbjct: 487 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 531
Score = 92.8 bits (229), Expect = 4e-19
Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
GH V C+ ++ K++ SGS D+ L VW ++ + GH AV CV + G +
Sbjct: 341 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 396
Query: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
SG+ D V++W P + + HT V S+ F DG V+ S D +++VW
Sbjct: 397 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 454
Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193
+ +L+ H + + + ++VS + D TVK+WD + +C+ + +H VT +
Sbjct: 455 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 512
Query: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
F+ + + + D TVK+WD++T +++
Sbjct: 513 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 541
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/250 (27%), Positives = 115/250 (46%), Gaps = 19/250 (7%)
Query: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
+ + FC G V+ SDD T+KVW+ K L +L H V ++ + +I+S S
Sbjct: 266 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 321
Query: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
D+T+K+W+ + EC+H+ H V + H + + D T++VWD+ T + L
Sbjct: 322 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVL 379
Query: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
H AAV + + G +++ + D +K+ D L+TL GH ++ F G +
Sbjct: 380 MGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIH 435
Query: 286 FASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSM---GNLTVS-ILEQRLTLTED 341
SG D + VW V+ G +L S M N+ VS + + + +
Sbjct: 436 VVSGSLDTSIRVWD-----VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 490
Query: 342 KLKQCLENQQ 351
K QCL+ Q
Sbjct: 491 KTGQCLQTLQ 500
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 130 bits (328), Expect = 1e-30
Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)
Query: 16 KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
KGH D +TC+ F N ++ SGS D+ L VW GH V +
Sbjct: 377 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 432
Query: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
++ SGS D+T+++W HT+TVR +H + V+ S D T++VW
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 490
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
+ L L H+ VRC ++ DGR +VS + D VK+WD + C+H+ H V +
Sbjct: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
F G + + +D +++VWDV T + H + +G+ N L++ ++DST+K
Sbjct: 549 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 604
Query: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298
I D+ G+ L TL G HQ T + F++ + + D V +W
Sbjct: 605 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 649
Score = 92.8 bits (229), Expect = 4e-19
Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
GH V C+ ++ K++ SGS D+ L VW ++ + GH AV CV + G +
Sbjct: 459 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 514
Query: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
SG+ D V++W P + + HT V S+ F DG V+ S D +++VW
Sbjct: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 572
Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193
+ +L+ H + + + ++VS + D TVK+WD + +C+ + +H VT +
Sbjct: 573 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
Query: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
F+ + + + D TVK+WD++T +++
Sbjct: 631 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/250 (27%), Positives = 115/250 (46%), Gaps = 19/250 (7%)
Query: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
+ + FC G V+ SDD T+KVW+ K L +L H V ++ + +I+S S
Sbjct: 384 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 439
Query: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
D+T+K+W+ + EC+H+ H V + H + + D T++VWD+ T + L
Sbjct: 440 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVL 497
Query: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
H AAV + + G +++ + D +K+ D L+TL GH ++ F G +
Sbjct: 498 MGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIH 553
Query: 286 FASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSM---GNLTVS-ILEQRLTLTED 341
SG D + VW V+ G +L S M N+ VS + + + +
Sbjct: 554 VVSGSLDTSIRVWD-----VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
Query: 342 KLKQCLENQQ 351
K QCL+ Q
Sbjct: 609 KTGQCLQTLQ 618
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 130 bits (328), Expect = 1e-30
Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)
Query: 16 KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
KGH D +TC+ F N ++ SGS D+ L VW GH V +
Sbjct: 297 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 352
Query: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
++ SGS D+T+++W HT+TVR +H + V+ S D T++VW
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 410
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
+ L L H+ VRC ++ DGR +VS + D VK+WD + C+H+ H V +
Sbjct: 411 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 468
Query: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
F G + + +D +++VWDV T + H + +G+ N L++ ++DST+K
Sbjct: 469 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 524
Query: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298
I D+ G+ L TL G HQ T + F++ + + D V +W
Sbjct: 525 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 569
Score = 92.8 bits (229), Expect = 4e-19
Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
GH V C+ ++ K++ SGS D+ L VW ++ + GH AV CV + G +
Sbjct: 379 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 434
Query: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
SG+ D V++W P + + HT V S+ F DG V+ S D +++VW
Sbjct: 435 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 492
Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193
+ +L+ H + + + ++VS + D TVK+WD + +C+ + +H VT +
Sbjct: 493 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 550
Query: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
F+ + + + D TVK+WD++T +++
Sbjct: 551 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 579
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/250 (27%), Positives = 115/250 (46%), Gaps = 19/250 (7%)
Query: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
+ + FC G V+ SDD T+KVW+ K L +L H V ++ + +I+S S
Sbjct: 304 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 359
Query: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
D+T+K+W+ + EC+H+ H V + H + + D T++VWD+ T + L
Sbjct: 360 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVL 417
Query: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
H AAV + + G +++ + D +K+ D L+TL GH ++ F G +
Sbjct: 418 MGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIH 473
Query: 286 FASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSM---GNLTVS-ILEQRLTLTED 341
SG D + VW V+ G +L S M N+ VS + + + +
Sbjct: 474 VVSGSLDTSIRVWD-----VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 528
Query: 342 KLKQCLENQQ 351
K QCL+ Q
Sbjct: 529 KTGQCLQTLQ 538
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 130 bits (327), Expect = 2e-30
Identities = 93/337 (27%), Positives = 149/337 (44%), Gaps = 52/337 (15%)
Query: 14 HF--KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNF- 69
HF KGHR V + +S + ++LASG + +++W + R GH +T +++
Sbjct: 149 HFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE 208
Query: 70 ----SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
+P +AS S+D +VRIW + HT +V + + DG + +AS D+
Sbjct: 209 PLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDR 267
Query: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL-------------------------- 159
T+KVW H +L H +WV S D L
Sbjct: 268 TIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE 327
Query: 160 ----------------IVSASDDKTVKLWDKSS-RECVHSYCEHGGFVTYVDFHPSGTCI 202
+VS SDD T+ LW + ++ + H + V F P +
Sbjct: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIV 387
Query: 203 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 262
A+A D ++K+WD RT + L + H AAV +++ L++ SSDSTLK+ D+ +
Sbjct: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 447
Query: 263 LLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
L L GH V +S G+ ASGG D+ + +W+
Sbjct: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 106 bits (265), Expect = 3e-23
Identities = 81/332 (24%), Positives = 137/332 (41%), Gaps = 50/332 (15%)
Query: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
+GH +AV V FS K LASGS D+ + W + ++ + GH+ V +++SP G
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
Query: 76 LASGSRDKTVRIWVPNV-KGESTVFRAHTATV-----RSVHFCSDGQSFVTASDDKTVKV 129
LASG ++ + +W P+ K H+ + +H + + ++S D +V++
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
Query: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
W T + L+ H V C ++ DG L+ SAS D+T+K+W + HG +
Sbjct: 231 WDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHW 289
Query: 190 VTYV-----------DFHPSGTCI-------------------------------AAAGM 207
V + F P+ + +
Sbjct: 290 VNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349
Query: 208 DNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
D T+ +W + L H A +N + F P + +AS D ++K+ D G+ L +
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409
Query: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
L GH +A+S SG SD + VW
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Score = 71.6 bits (174), Expect = 1e-12
Identities = 49/169 (28%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPS 198
SL H V FSP G+ + S S D TV+ WD S+ E H C+ H +V + + P
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST-ETPHFTCKGHRHWVLSISWSPD 167
Query: 199 GTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSF-----HPSGNYLITASSDST 252
G +A+ + + +WD T + + + HS + GLS+ +P Y+ ++S D +
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
Query: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
++I D GR L GH T + + G + S D + VW+++
Sbjct: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAH 275
Score = 62.4 bits (150), Expect = 6e-10
Identities = 35/125 (28%), Positives = 57/125 (45%)
Query: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
AED GH+ + V FS +++ +AS S D + +W + GH AV
Sbjct: 359 AEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 418
Query: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
+ +S LL SGS D T+++W + + H V +V + DGQ + DK
Sbjct: 419 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478
Query: 126 TVKVW 130
+++W
Sbjct: 479 CLRIW 483
Score = 44.7 bits (104), Expect = 1e-04
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 6/126 (4%)
Query: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
C S H V V F P+G +A+ D TV+ WD+ T + H V +S+
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 239 PSGNYLITASSDSTLKILDLMEGRLL-YTLHGHQGPATTVAF-----SRTGEYFASGGSD 292
P G L + + + + D G+ + TL GH T +++ + Y AS D
Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 293 EQVMVW 298
V +W
Sbjct: 226 GSVRIW 231
Score = 36.6 bits (83), Expect = 0.036
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
R +L GH +VAFS TG+Y ASG D V W
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFW 141
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 129 bits (323), Expect = 5e-30
Identities = 76/237 (32%), Positives = 115/237 (48%), Gaps = 3/237 (1%)
Query: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
SG LLA+G D V +W N HT+ V SV + + V S +++VW
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Query: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 191
K L +L H + F P G + S S D +KLWD + CV Y H V
Sbjct: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
Query: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
+ F P G +A+A D+TVK+WD+ +++ + H+ VN + FHP+ L + SSD
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
Query: 252 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE-QVMVWKSN--FDIV 305
T++ DL + +++ + G GP +V F+ G SG D +V W+ FD+V
Sbjct: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV 268
Score = 124 bits (312), Expect = 1e-28
Identities = 64/218 (29%), Positives = 107/218 (49%)
Query: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 93
LA+G D + +W + + TGH V V + L+ +GS+ ++R+W
Sbjct: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
Query: 94 GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF 153
H A + S+ F G+ + S D +K+W R+ +F H VRC +F
Sbjct: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155
Query: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
SPDG+ + SA+DD TVKLWD ++ + + + H G V V+FHP+ +A+ D T++
Sbjct: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
Query: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
WD+ +++ + V + F+P G L + DS
Sbjct: 216 WDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
Score = 122 bits (306), Expect = 5e-28
Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 1/199 (0%)
Query: 101 AHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159
AH + V S+ + G+ T DD V +W+ ++ + SL+ H + V + + L
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
IV+ S ++++WD + + + + H + +DFHP G +A+ D +K+WD+R
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 279
+ Y+ HS AV L F P G +L +A+ D T+K+ DL G+++ GH GP V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 280 SRTGEYFASGGSDEQVMVW 298
ASG SD + W
Sbjct: 198 HPNEYLLASGSSDRTIRFW 216
Score = 107 bits (267), Expect = 2e-23
Identities = 58/201 (28%), Positives = 93/201 (46%)
Query: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVN 68
P+ GH V V + + + +GS + VW ++ GHK + ++
Sbjct: 53 PNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLD 112
Query: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
F P G +ASGS+D +++W KG +R H+ VR + F DG+ +A+DD TVK
Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172
Query: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
+W K + H V +F P+ L+ S S D+T++ WD + V G
Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG 232
Query: 189 FVTYVDFHPSGTCIAAAGMDN 209
V V F+P G C+ + D+
Sbjct: 233 PVRSVLFNPDGCCLYSGCQDS 253
Score = 88.6 bits (218), Expect = 8e-18
Identities = 47/160 (29%), Positives = 77/160 (48%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
E + R GH+ + +DF + +ASGS D+ + +W ++ + +R+ GH AV C
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
+ FSP G LAS + D TV++W + F HT V V F + + S D+T
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD 166
++ W + + + + VR F+PDG + S D
Sbjct: 213 IRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 128 bits (321), Expect = 9e-30
Identities = 88/289 (30%), Positives = 132/289 (45%), Gaps = 11/289 (3%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHL 75
GH V C F N LAS D +++W++ Y GH AV ++++ G +
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV-TASDDKTVKVWATHR 134
L S S DKTV +W + HT+ V S + G V T SDD TVK+W R
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-R 182
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
+K Q+ V F+ I+S D +K+WD + ++ H VT +
Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
Query: 195 FHPSGTCIAAAGMDNTVKVWDVRT----HRLLQHYQ--LHSAAVNGL--SFHPSGNYLIT 246
G+ + + MDNTV+VWDVR R ++ +Q +H+ N L S+ P G+ +
Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
Query: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
S+D + + D R+LY L GH G VAF S SD+++
Sbjct: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 124 bits (312), Expect = 1e-28
Identities = 76/257 (29%), Positives = 130/257 (50%), Gaps = 23/257 (8%)
Query: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 114
+GH+ V C F P+G LAS D+ + +W NV G+ + H+ V +H+ +D
Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120
Query: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 173
G +AS DKTV VW + + + L H ++V C +L+ + SDD TVKLWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
+ + ++ ++ V V F+ + I + G+DN +KVWD+R ++L + H+ +V
Sbjct: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
Query: 234 GLSFHPSGNYLITASSDSTLKILD------------LMEGRLLYTLHGHQGPATTVAFSR 281
GLS G+YL++ + D+T+++ D + +G +H + ++S
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG----NVHNFEKNLLRCSWSP 295
Query: 282 TGEYFASGGSDEQVMVW 298
G A+G +D V VW
Sbjct: 296 DGSKIAAGSADRFVYVW 312
Score = 108 bits (269), Expect = 1e-23
Identities = 71/250 (28%), Positives = 116/250 (46%), Gaps = 16/250 (6%)
Query: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV-TCVNFSPSGH 74
KGH AV + ++ + L S S D + VW + R R GH V +C
Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
Query: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
L+ +GS D TV++W K F+ +T V +V F ++ D +KVW +
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----------KSSRECVHSY 183
K +++ H + V S +G ++S + D TV++WD K + VH++
Sbjct: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284
Query: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
++ + + P G+ IAA D V VWD + R+L H+ ++N ++FHP
Sbjct: 285 EKN---LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
Query: 244 LITASSDSTL 253
+I+ASSD L
Sbjct: 342 IISASSDKRL 351
Score = 80.5 bits (197), Expect = 2e-15
Identities = 56/202 (27%), Positives = 83/202 (41%), Gaps = 45/202 (22%)
Query: 141 LSQHINWVRCAKFSP-------------------------------------------DG 157
LS H V C KF P DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN-TVKVWDV 216
++ SAS DKTV +WD + E V H FV G + G D+ TVK+WD+
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 276
R +Q +Q ++ V ++F+ + + +I+ D+ +K+ DL + +L YT+ GH T
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 277 VAFSRTGEYFASGGSDEQVMVW 298
++ S G Y S D V VW
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVW 262
Score = 37.7 bits (86), Expect = 0.016
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 286
H V FHP+G+ L +A D + + ++ Y TL GH G + ++ G
Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
Query: 287 ASGGSDEQVMVWKS 300
S +D+ V VW S
Sbjct: 125 FSASTDKTVAVWDS 138
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 126 bits (317), Expect = 3e-29
Identities = 75/244 (30%), Positives = 115/244 (47%), Gaps = 11/244 (4%)
Query: 55 YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 114
Y F +T V+ + L+A G D TVR+W K +RSV SD
Sbjct: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPK-----------KLRSVKQASD 512
Query: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
SDD ++ L L H V A FSPD ++S+S+D TV+LW
Sbjct: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
+ C+ Y H V F P G + G D ++W ++ L+ + H A VN
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
Query: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294
FHP+ NY+ T S+D T+++ D++ G + GH+GP ++ FS G + A+G +D +
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692
Query: 295 VMVW 298
V++W
Sbjct: 693 VLLW 696
Score = 124 bits (310), Expect = 2e-28
Identities = 74/277 (26%), Positives = 122/277 (44%), Gaps = 11/277 (3%)
Query: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
+T VD + ++ +A G DS + VW + P+ + V + L+ S
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESD 521
Query: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
D RI E + H+ V F D +++S+D TV++W+ L
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
H V +FSP G VS D+ +LW + + + H V FHP+
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641
Query: 202 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 261
+A D TV++WDV ++ + H ++ L+F P+G +L T ++D + + D+ G
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Query: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
++ L GH ++ FSR GE ASG D V +W
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 99.0 bits (245), Expect = 6e-21
Identities = 57/199 (28%), Positives = 85/199 (42%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
GH V FS + L S S D + +W ++ + + GH V FSP G+
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
Query: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
SG D+ R+W + +F H A V F + T S D+TV++W
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH 196
+ + H + FSP+GR + + + D V LWD V H V + F
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
Query: 197 PSGTCIAAAGMDNTVKVWD 215
G +A+ MDNTV++WD
Sbjct: 721 RDGEILASGSMDNTVRLWD 739
Score = 85.9 bits (211), Expect = 5e-17
Identities = 49/159 (30%), Positives = 70/159 (44%)
Query: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
+KGH V FS SG D +W F GH V C F P+ +
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
Query: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
+A+GS D+TVR+W +F H + S+ F +G+ T + D V +W
Sbjct: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
Query: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
+ L H + V +FS DG ++ S S D TV+LWD
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 76.3 bits (186), Expect = 4e-14
Identities = 41/118 (34%), Positives = 60/118 (50%)
Query: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
R F GH V C F N+ +A+GS D + +W + + FTGHK + + FSP+
Sbjct: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680
Query: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
G LA+G+ D V +W + HT TV S+ F DG+ + S D TV++W
Sbjct: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 61.6 bits (148), Expect = 1e-09
Identities = 42/154 (27%), Positives = 59/154 (38%), Gaps = 31/154 (20%)
Query: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL----------- 227
C +++ +T VD + IA D+TV+VW V +L Q
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
Query: 228 --------------------HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
HS V G SF P NYL+++S D T+++ L L
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
GH P FS G YF SGG D +W ++
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 125 bits (315), Expect = 4e-29
Identities = 84/284 (29%), Positives = 127/284 (44%), Gaps = 4/284 (1%)
Query: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
+ F H V FS + + L +GS D C+ W + +R GH V FSP
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
GHL AS S D TVR+W V + H +V +V F D + + DK V +W
Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSRECVHSYCE-HGGF 189
+ L L H + ++ + FSP + + S D TV +WD + H E H
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
Query: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
++ + + SG +A+ D T+ +W T LL + H V ++F P +L +A
Sbjct: 195 ISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253
Query: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 293
+K+ D G+ L TL G A T AF+ G+ SG +D+
Sbjct: 254 SRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
Score = 125 bits (313), Expect = 8e-29
Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)
Query: 53 RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 109
R +F G H V FSP G +L +GS D V W + ++R HT V+
Sbjct: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69
Query: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169
F DG F +AS D TV++W R K L L H V FSPD R + S DK V
Sbjct: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
Query: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 223
LWD S + + H + DF P+ C+A D+TV +WD+R +H+ L+
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
Query: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
HSA ++ L + SG L + S D T+ I LL L GH ++AFS
Sbjct: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
Query: 284 EYFASGGSDEQVMVWKSN 301
+ AS G V VW N
Sbjct: 246 LWLASAGYSRMVKVWDCN 263
Score = 108 bits (271), Expect = 6e-24
Identities = 62/203 (30%), Positives = 100/203 (49%), Gaps = 8/203 (3%)
Query: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
R KGH+ +V V FS +++QLASG D +M+W ++ GH+D++ +FSP+
Sbjct: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
Query: 73 GHLLASGSRDKTVRIW-----VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127
+ LA+GS D TV IW P V ++ H+A + + + + G + S DKT+
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQA--LEGHSANISCLCYSASG-LLASGSWDKTI 215
Query: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
+W L L H+ WV+ FSPD + SA + VK+WD ++ +C+ +
Sbjct: 216 HIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVL 275
Query: 188 GFVTYVDFHPSGTCIAAAGMDNT 210
F P G + + D T
Sbjct: 276 DVAHTCAFTPDGKILVSGAADQT 298
Score = 97.4 bits (241), Expect = 2e-20
Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 4/164 (2%)
Query: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSG 73
GHRD++ DFS LA+GS DS + +W ++ P GH ++C+ +S SG
Sbjct: 145 GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204
Query: 74 HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
LLASGS DKT+ IW P + H V+S+ F D +A + VKVW +
Sbjct: 205 -LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
Query: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
K L +L ++ F+PDG+++VS + D+T + ++S+
Sbjct: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
Score = 35.8 bits (81), Expect = 0.061
Identities = 24/77 (31%), Positives = 31/77 (40%)
Query: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
SL KGH V + FS + LAS + VW G D F
Sbjct: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283
Query: 70 SPSGHLLASGSRDKTVR 86
+P G +L SG+ D+T R
Sbjct: 284 TPDGKILVSGAADQTRR 300
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 125 bits (313), Expect = 8e-29
Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 10/296 (3%)
Query: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
R KGH + V C+D+ + +++ S S D ++VW ++ + T V ++PS
Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
Query: 73 GHLLASGSRDKTVRIWV------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
G +A G D ++ N+ + HT + + F + +TAS D T
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--GRLIVSASDDKTVKLWDKSSRECVHSYC 184
+W + L S H V C +P G VS DK +WD S +CV ++
Sbjct: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236
Query: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGN 242
H + V ++PSG A+ D T +++D+R R + Y S + + F SG
Sbjct: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 296
Query: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
L +D T+ + D+++G + L GH+ +T+ S G F SG D + VW
Sbjct: 297 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/171 (26%), Positives = 60/171 (35%), Gaps = 46/171 (26%)
Query: 7 EDPSLERHFKGHRDAVTCVDF--SINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV 64
E L + F GH V C+D S SG D MVW M+ F H+ +
Sbjct: 183 ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI 242
Query: 65 TCVNFSPSGHLLASGSRDKTVRIW-------VPNVKGESTVFRA---------------- 101
V + PSG ASGS D T R++ V ES +F A
Sbjct: 243 NSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGY 302
Query: 102 ---------------------HTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
H V ++ DG +F + S D T++VWA
Sbjct: 303 NDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 125 bits (313), Expect = 8e-29
Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 10/296 (3%)
Query: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
R KGH + V C+D+ + +++ S S D ++VW ++ + T V ++PS
Sbjct: 99 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
Query: 73 GHLLASGSRDKTVRIWV------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
G +A G D ++ N+ + HT + + F + +TAS D T
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--GRLIVSASDDKTVKLWDKSSRECVHSYC 184
+W + L S H V C +P G VS DK +WD S +CV ++
Sbjct: 219 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 278
Query: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGN 242
H + V ++PSG A+ D T +++D+R R + Y S + + F SG
Sbjct: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 338
Query: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
L +D T+ + D+++G + L GH+ +T+ S G F SG D + VW
Sbjct: 339 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 51.6 bits (122), Expect = 1e-06
Identities = 45/171 (26%), Positives = 60/171 (35%), Gaps = 46/171 (26%)
Query: 7 EDPSLERHFKGHRDAVTCVDF--SINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV 64
E L + F GH V C+D S SG D MVW M+ F H+ +
Sbjct: 225 ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI 284
Query: 65 TCVNFSPSGHLLASGSRDKTVRIW-------VPNVKGESTVFRA---------------- 101
V + PSG ASGS D T R++ V ES +F A
Sbjct: 285 NSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGY 344
Query: 102 ---------------------HTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
H V ++ DG +F + S D T++VWA
Sbjct: 345 NDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 117 bits (292), Expect = 2e-26
Identities = 81/270 (30%), Positives = 129/270 (47%), Gaps = 7/270 (2%)
Query: 30 NTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW- 88
+T ++ +G D ++V+ + GH VT V F PS L+ S S D T+RIW
Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
Query: 89 VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW- 147
VPN V RAH + V + + G +++SDD+ + L ++ +
Sbjct: 293 VPNASCVQVV-RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
Query: 148 -VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206
+ CA+F PDG + + + D +K+WD R V ++ H G +T + F +G +A A
Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
Query: 207 MDNTVKVWDVRTHRLLQHYQL-HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 265
D++VK+WD+R + + QL ++ V L F SG YL +D + I L +
Sbjct: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHF 471
Query: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
T H G T VAF ++ AS G D +
Sbjct: 472 T--EHSGLTTGVAFGHHAKFIASTGMDRSL 499
Score = 100 bits (249), Expect = 2e-21
Identities = 58/188 (30%), Positives = 86/188 (45%), Gaps = 2/188 (1%)
Query: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
SD +T DK V V+ ++ L +L H V F P L+ SAS D T+++W
Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
Query: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--QLHSA 230
+ CV H VT + H +G + ++ D D++T R+L +
Sbjct: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
Query: 231 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
++ FHP G T + DS +KI DL E + GH GP T++AFS G Y A+
Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
Query: 291 SDEQVMVW 298
D V +W
Sbjct: 412 DDSSVKLW 419
Score = 97.1 bits (240), Expect = 2e-20
Identities = 60/242 (24%), Positives = 111/242 (45%), Gaps = 6/242 (2%)
Query: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
+ +G DK V ++ + + + HT V SV F +AS D T+++W+
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
Query: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH--GGFVTYV 193
+ + H + V G ++S+SDD+ D + + + G +T
Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
Query: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
FHP G MD+ +K+WD++ + ++ HS + ++F +G YL TA+ DS++
Sbjct: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSV 416
Query: 254 KILDLMEGRLLYTLH-GHQGPATTVAFSRTGEYFASGGSDEQVMV---WKSNFDIVDHGE 309
K+ DL + + TL + ++ F ++G Y A GG+D Q+ + W +H
Sbjct: 417 KLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSG 476
Query: 310 VT 311
+T
Sbjct: 477 LT 478
Score = 80.5 bits (197), Expect = 2e-15
Identities = 63/249 (25%), Positives = 105/249 (42%), Gaps = 11/249 (4%)
Query: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
KGH VT V F + + S S D+ + +W + S H+ AVT ++ +G
Sbjct: 261 KGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY 320
Query: 76 LASGSRDKTVRIWVPNVKGESTVFRAHT-----ATVRSVHFCSDGQSFVTASDDKTVKVW 130
L S S D + W + V T ++ F DG F T + D +K+W
Sbjct: 321 LLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIW 377
Query: 131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF- 189
+ + + H + FS +G + +A+DD +VKLWD + + F
Sbjct: 378 DLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE 437
Query: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
V + F SGT +A G D V+++ + + H+ HS G++F ++ +
Sbjct: 438 VKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGM 495
Query: 250 DSTLKILDL 258
D +LK L
Sbjct: 496 DRSLKFYSL 504
Score = 37.7 bits (86), Expect = 0.016
Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 3/119 (2%)
Query: 14 HFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNFSPS 72
+F GH +T + FS N LA+ + DS + +W ++ + V + F S
Sbjct: 387 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQS 446
Query: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
G LA G D V+I++ E F H+ V F + + D+++K ++
Sbjct: 447 GTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 503
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 117 bits (292), Expect = 2e-26
Identities = 77/285 (27%), Positives = 126/285 (44%), Gaps = 12/285 (4%)
Query: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
VT +D++ LA+GS D +W K + A HK + + ++ G+ + S
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
DKT IW + F H+A V + S+ +F + S D + V + + + +
Sbjct: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN-TFASCSTDMCIHVCKLGQDRPIKTF 345
Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT- 200
H N V K+ P G L+ S SDD T+K+W CVH H + + + P+G
Sbjct: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405
Query: 201 --------CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
+A+A D+TV++WDV + H V ++F P G YL + S D
Sbjct: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465
Query: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
+ I + G L+++ G G V ++ G+ + SD V V
Sbjct: 466 VHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCV 509
Score = 110 bits (275), Expect = 2e-24
Identities = 83/322 (25%), Positives = 145/322 (45%), Gaps = 39/322 (12%)
Query: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA---------------YRFTGH 60
+GH V ++ + LASGS DS +W++ S + +
Sbjct: 166 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSN 225
Query: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
KD VT ++++ G LLA+GS D RIW + ST+ + H + ++ + G ++
Sbjct: 226 KD-VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQ-HKGPIFALKWNKKGNFILS 283
Query: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
A DKT +W H +Q+F F + ++W F+ S S D + +
Sbjct: 284 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFA-------SCSTDMCIHVCKL 336
Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
+ ++ H V + + P+G +A+ D T+K+W ++ + Q H+ +
Sbjct: 337 GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYT 396
Query: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
+ + P+G L +AS DST+++ D+ G ++TL HQ P +VAFS G Y
Sbjct: 397 IKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRY 456
Query: 286 FASGGSDEQVMVWKSNFDIVDH 307
ASG D+ V +W + + H
Sbjct: 457 LASGSFDKCVHIWNTQTGALVH 478
Score = 96.7 bits (239), Expect = 3e-20
Identities = 67/217 (30%), Positives = 107/217 (49%), Gaps = 15/217 (6%)
Query: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
++ F H VD+ N AS S D C+ V + F GH + V + + P
Sbjct: 301 KQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDP 359
Query: 72 SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
+G+LLAS S D T++IW ++K ++ V +AH + ++ + G +
Sbjct: 360 TGNLLASCSDDMTLKIW--SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417
Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
AS D TV++W R + +L++H V FSPDGR + S S DK V +W+ + V
Sbjct: 418 ASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALV 477
Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
HSY GG + V ++ +G + A+ D +V V D+R
Sbjct: 478 HSYRGTGG-IFEVCWNAAGDKVGASASDGSVCVLDLR 513
Score = 94.7 bits (234), Expect = 1e-19
Identities = 61/261 (23%), Positives = 116/261 (44%), Gaps = 11/261 (4%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
+D +L H+ + + ++ + S +D ++W +F H
Sbjct: 254 KDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 313
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
V++ S + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 314 VDWQ-SNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMT 372
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
+K+W+ + + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 373 LKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRG 432
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
C+H+ +H V V F P G +A+ D V +W+ +T L+ Y+ + + + +
Sbjct: 433 ICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR-GTGGIFEVCW 491
Query: 238 HPSGNYLITASSDSTLKILDL 258
+ +G+ + ++SD ++ +LDL
Sbjct: 492 NAAGDKVGASASDGSVCVLDL 512
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 116 bits (291), Expect = 3e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)
Query: 57 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 112
F H V V FSP LLA+G D+ V++W V GE F+ A + S+ F
Sbjct: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 375
Query: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
S G + AS+D ++W + +L+ H V AKF D IVS S D+T+KLW
Sbjct: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
Query: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 232
D S+ C+ + + D + C+ + D ++ WD+R+ +++ +L +
Sbjct: 436 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 491
Query: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 288
L +P L++ S D LK++DL + T T V FS G Y A+
Sbjct: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 551
Query: 289 GGSDEQVMVWKSNFDIVDHGEVTKV 313
G ++ + +W V G+V KV
Sbjct: 552 GSAEGSLYIWS-----VLTGKVEKV 571
Score = 99.8 bits (247), Expect = 3e-21
Identities = 74/294 (25%), Positives = 131/294 (44%), Gaps = 17/294 (5%)
Query: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPS 72
F H V V FS ++ LA+G MD + +W + + ++ +G +T + F +
Sbjct: 318 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 377
Query: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
G L + S D RIW + H+ V S F D V+ S D+T+K+W
Sbjct: 378 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
Query: 133 HRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
+ K +F+ S N + C + + ++S DK ++ WD S V E G
Sbjct: 438 RSKVCIKTVFAGSS-CNDIVCTE-----QCVMSGHFDKKIRFWDIRSESIVRE-MELLGK 490
Query: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG----LSFHPSGNYLI 245
+T +D +P T + + D+ +KV D+RT+ + Q + + F P G+Y+
Sbjct: 491 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 550
Query: 246 TASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
S++ +L I ++ G++ L H VA+S +G + S + ++W
Sbjct: 551 AGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
Score = 46.6 bits (109), Expect = 3e-05
Identities = 50/217 (23%), Positives = 89/217 (41%), Gaps = 17/217 (7%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVT 65
+D L GH V F ++ ++ SGS D L +W ++ + F G +
Sbjct: 396 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS----S 451
Query: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH-TATVRSVHFCSDGQSFVTASDD 124
C + + + SG DK +R W +++ ES V + ++ + ++ S D
Sbjct: 452 CNDIVCTEQCVMSGHFDKKIRFW--DIRSESIVREMELLGKITALDLNPERTELLSCSRD 509
Query: 125 KTVKV--WATHRQKFLFS---LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSR 177
+KV T+ K FS +W R FSPDG + + S + ++ +W
Sbjct: 510 DLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV-FSPDGSYVAAGSAEGSLYIWSVLTGKV 568
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
E V S +H + V + PSG+ + + +W
Sbjct: 569 EKVLSK-QHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 116 bits (291), Expect = 3e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 19/265 (7%)
Query: 57 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH----TATVRSVHFC 112
F H V V FSP LLA+G D+ V++W V GE F+ A + S+ F
Sbjct: 299 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW--EVFGEKCEFKGSLSGSNAGITSIEFD 356
Query: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
S G + AS+D ++W + +L+ H V AKF D IVS S D+T+KLW
Sbjct: 357 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 416
Query: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 232
D S+ C+ + + D + C+ + D ++ WD+R+ +++ +L +
Sbjct: 417 DLRSKVCIKTVFAGS---SCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMEL-LGKI 472
Query: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPATTVAFSRTGEYFAS 288
L +P L++ S D LK++DL + T T V FS G Y A+
Sbjct: 473 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 532
Query: 289 GGSDEQVMVWKSNFDIVDHGEVTKV 313
G ++ + +W V G+V KV
Sbjct: 533 GSAEGSLYIWS-----VLTGKVEKV 552
Score = 99.8 bits (247), Expect = 3e-21
Identities = 74/294 (25%), Positives = 131/294 (44%), Gaps = 17/294 (5%)
Query: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPS 72
F H V V FS ++ LA+G MD + +W + + ++ +G +T + F +
Sbjct: 299 FDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA 358
Query: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
G L + S D RIW + H+ V S F D V+ S D+T+K+W
Sbjct: 359 GSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 418
Query: 133 HRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
+ K +F+ S N + C + + ++S DK ++ WD S V E G
Sbjct: 419 RSKVCIKTVFAGSS-CNDIVCTE-----QCVMSGHFDKKIRFWDIRSESIVRE-MELLGK 471
Query: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG----LSFHPSGNYLI 245
+T +D +P T + + D+ +KV D+RT+ + Q + + F P G+Y+
Sbjct: 472 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVA 531
Query: 246 TASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
S++ +L I ++ G++ L H VA+S +G + S + ++W
Sbjct: 532 AGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 585
Score = 46.6 bits (109), Expect = 3e-05
Identities = 50/217 (23%), Positives = 89/217 (41%), Gaps = 17/217 (7%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVT 65
+D L GH V F ++ ++ SGS D L +W ++ + F G +
Sbjct: 377 DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGS----S 432
Query: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH-TATVRSVHFCSDGQSFVTASDD 124
C + + + SG DK +R W +++ ES V + ++ + ++ S D
Sbjct: 433 CNDIVCTEQCVMSGHFDKKIRFW--DIRSESIVREMELLGKITALDLNPERTELLSCSRD 490
Query: 125 KTVKV--WATHRQKFLFS---LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSR 177
+KV T+ K FS +W R FSPDG + + S + ++ +W
Sbjct: 491 DLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV-FSPDGSYVAAGSAEGSLYIWSVLTGKV 549
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
E V S +H + V + PSG+ + + +W
Sbjct: 550 EKVLSK-QHSSSINAVAWSPSGSHVVSVDKGCKAVLW 585
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 116 bits (291), Expect = 3e-26
Identities = 91/329 (27%), Positives = 148/329 (44%), Gaps = 39/329 (11%)
Query: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFT 58
P+ +GH V ++ + LASGS DS +W++ S R
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 59 GH-----KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
GH KD VT ++++ G LLA GS D RIW N ST+ + H + ++ +
Sbjct: 229 GHDVPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQ-HKGPIFALKWNK 286
Query: 114 DGQSFVTASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDK 167
G ++A DKT +W H +Q+F F + ++W F+ S S D
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-------SCSTDM 339
Query: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
+ + V ++ H V + + PSG +A+ D T+K+W ++ + Q
Sbjct: 340 CIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA 399
Query: 228 HSAAVNGLSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
HS + + + P+G L +AS DST+++ D+ +G +TL HQ P +VA
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459
Query: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDH 307
FS G+Y ASG D+ V +W + + H
Sbjct: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLVH 488
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/261 (22%), Positives = 113/261 (43%), Gaps = 11/261 (4%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
E+ +L H+ + + ++ + S +D ++W +F H
Sbjct: 264 ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 324 VDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
+K+W+ + + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 383 LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG 442
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
C H+ +H V V F P G +A+ D V +W+ ++ L+ YQ + + + +
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCW 501
Query: 238 HPSGNYLITASSDSTLKILDL 258
+ G+ + ++SD ++ +LDL
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 116 bits (291), Expect = 3e-26
Identities = 91/329 (27%), Positives = 148/329 (44%), Gaps = 39/329 (11%)
Query: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFT 58
P+ +GH V ++ + LASGS DS +W++ S R
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 59 GH-----KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
GH KD VT ++++ G LLA GS D RIW N ST+ + H + ++ +
Sbjct: 229 GHDVPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQ-HKGPIFALKWNK 286
Query: 114 DGQSFVTASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDK 167
G ++A DKT +W H +Q+F F + ++W F+ S S D
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-------SCSTDM 339
Query: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
+ + V ++ H V + + PSG +A+ D T+K+W ++ + Q
Sbjct: 340 CIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA 399
Query: 228 HSAAVNGLSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
HS + + + P+G L +AS DST+++ D+ +G +TL HQ P +VA
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459
Query: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDH 307
FS G+Y ASG D+ V +W + + H
Sbjct: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLVH 488
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/261 (22%), Positives = 113/261 (43%), Gaps = 11/261 (4%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
E+ +L H+ + + ++ + S +D ++W +F H
Sbjct: 264 ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 324 VDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
+K+W+ + + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 383 LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG 442
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
C H+ +H V V F P G +A+ D V +W+ ++ L+ YQ + + + +
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCW 501
Query: 238 HPSGNYLITASSDSTLKILDL 258
+ G+ + ++SD ++ +LDL
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 116 bits (291), Expect = 3e-26
Identities = 91/329 (27%), Positives = 148/329 (44%), Gaps = 39/329 (11%)
Query: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFT 58
P+ +GH V ++ + LASGS DS +W++ S R
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 59 GH-----KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
GH KD VT ++++ G LLA GS D RIW N ST+ + H + ++ +
Sbjct: 229 GHDVPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQ-HKGPIFALKWNK 286
Query: 114 DGQSFVTASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDK 167
G ++A DKT +W H +Q+F F + ++W F+ S S D
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-------SCSTDM 339
Query: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
+ + V ++ H V + + PSG +A+ D T+K+W ++ + Q
Sbjct: 340 CIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA 399
Query: 228 HSAAVNGLSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
HS + + + P+G L +AS DST+++ D+ +G +TL HQ P +VA
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459
Query: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDH 307
FS G+Y ASG D+ V +W + + H
Sbjct: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLVH 488
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/261 (22%), Positives = 113/261 (43%), Gaps = 11/261 (4%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
E+ +L H+ + + ++ + S +D ++W +F H
Sbjct: 264 ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 324 VDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
+K+W+ + + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 383 LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG 442
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
C H+ +H V V F P G +A+ D V +W+ ++ L+ YQ + + + +
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCW 501
Query: 238 HPSGNYLITASSDSTLKILDL 258
+ G+ + ++SD ++ +LDL
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 115 bits (287), Expect = 8e-26
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)
Query: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
VT +D++ N LA+GS D +W + + A HK + + ++ G+ + S
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
DKT IW + F H+A V + + +F + S D + V + + +
Sbjct: 299 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 357
Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
H N V K+ P G L+ S SDD T+K+W C+H H + + + P+G
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417
Query: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
+A+A D+TV++WD+ TH L +H + V ++F P G YL + S
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 473
Query: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
D + I + G L+++ G G V ++ G+ + SD V V
Sbjct: 474 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 521
Score = 113 bits (282), Expect = 3e-25
Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)
Query: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60
+GH V ++ + LASGS DS +W++ S R GH
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237
Query: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
KD VT ++++ +G LLA+GS D RIW + ST+ + H + ++ + G ++
Sbjct: 238 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 295
Query: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
A DKT +W H +Q+F F + ++W F+ S S D + +
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 348
Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
V ++ H V + + PSG +A+ D T+K+W ++ + Q H+ +
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408
Query: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
+ + P+G L +AS DST+++ D+ G +TL HQ P +VAFS G+Y
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468
Query: 286 FASGGSDEQVMVWKS 300
ASG D+ V +W +
Sbjct: 469 LASGSFDKCVHIWNT 483
Score = 97.1 bits (240), Expect = 2e-20
Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)
Query: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
++ F H VD+ NT AS S D C+ V + F GH + V + + P
Sbjct: 313 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 371
Query: 72 SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
SG LLAS S D T++IW ++K E + +AH + ++ + G + +
Sbjct: 372 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 429
Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
AS D TV++W R +L++H V FSPDG+ + S S DK V +W+ S V
Sbjct: 430 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 489
Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
HSY GG + V ++ G + A+ D +V V D+R
Sbjct: 490 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 92.4 bits (228), Expect = 5e-19
Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
ED +L H+ + + ++ + S +D ++W +F H
Sbjct: 266 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 325
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 326 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 384
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
+K+W+ ++ + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 385 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 444
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
C H+ +H V V F P G +A+ D V +W+ ++ L+ Y+ + + + +
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 503
Query: 238 HPSGNYLITASSDSTLKILDL 258
+ G+ + ++SD ++ +LDL
Sbjct: 504 NARGDKVGASASDGSVCVLDL 524
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 115 bits (287), Expect = 8e-26
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)
Query: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
VT +D++ N LA+GS D +W + + A HK + + ++ G+ + S
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
DKT IW + F H+A V + + +F + S D + V + + +
Sbjct: 299 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 357
Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
H N V K+ P G L+ S SDD T+K+W C+H H + + + P+G
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417
Query: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
+A+A D+TV++WD+ TH L +H + V ++F P G YL + S
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 473
Query: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
D + I + G L+++ G G V ++ G+ + SD V V
Sbjct: 474 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 521
Score = 113 bits (282), Expect = 3e-25
Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)
Query: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60
+GH V ++ + LASGS DS +W++ S R GH
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237
Query: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
KD VT ++++ +G LLA+GS D RIW + ST+ + H + ++ + G ++
Sbjct: 238 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 295
Query: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
A DKT +W H +Q+F F + ++W F+ S S D + +
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 348
Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
V ++ H V + + PSG +A+ D T+K+W ++ + Q H+ +
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408
Query: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
+ + P+G L +AS DST+++ D+ G +TL HQ P +VAFS G+Y
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468
Query: 286 FASGGSDEQVMVWKS 300
ASG D+ V +W +
Sbjct: 469 LASGSFDKCVHIWNT 483
Score = 97.1 bits (240), Expect = 2e-20
Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)
Query: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
++ F H VD+ NT AS S D C+ V + F GH + V + + P
Sbjct: 313 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 371
Query: 72 SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
SG LLAS S D T++IW ++K E + +AH + ++ + G + +
Sbjct: 372 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 429
Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
AS D TV++W R +L++H V FSPDG+ + S S DK V +W+ S V
Sbjct: 430 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 489
Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
HSY GG + V ++ G + A+ D +V V D+R
Sbjct: 490 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 92.4 bits (228), Expect = 5e-19
Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
ED +L H+ + + ++ + S +D ++W +F H
Sbjct: 266 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 325
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 326 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 384
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
+K+W+ ++ + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 385 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 444
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
C H+ +H V V F P G +A+ D V +W+ ++ L+ Y+ + + + +
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 503
Query: 238 HPSGNYLITASSDSTLKILDL 258
+ G+ + ++SD ++ +LDL
Sbjct: 504 NARGDKVGASASDGSVCVLDL 524
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 115 bits (287), Expect = 8e-26
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)
Query: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
VT +D++ N LA+GS D +W + + A HK + + ++ G+ + S
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
Query: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
DKT IW + F H+A V + + +F + S D + V + + +
Sbjct: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 408
Query: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
H N V K+ P G L+ S SDD T+K+W C+H H + + + P+G
Sbjct: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
Query: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
+A+A D+TV++WD+ TH L +H + V ++F P G YL + S
Sbjct: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 524
Query: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
D + I + G L+++ G G V ++ G+ + SD V V
Sbjct: 525 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 572
Score = 113 bits (282), Expect = 3e-25
Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)
Query: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60
+GH V ++ + LASGS DS +W++ S R GH
Sbjct: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
Query: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
KD VT ++++ +G LLA+GS D RIW + ST+ + H + ++ + G ++
Sbjct: 289 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 346
Query: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
A DKT +W H +Q+F F + ++W F+ S S D + +
Sbjct: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399
Query: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
V ++ H V + + PSG +A+ D T+K+W ++ + Q H+ +
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
Query: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
+ + P+G L +AS DST+++ D+ G +TL HQ P +VAFS G+Y
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
Query: 286 FASGGSDEQVMVWKS 300
ASG D+ V +W +
Sbjct: 520 LASGSFDKCVHIWNT 534
Score = 97.1 bits (240), Expect = 2e-20
Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)
Query: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
++ F H VD+ NT AS S D C+ V + F GH + V + + P
Sbjct: 364 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
Query: 72 SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
SG LLAS S D T++IW ++K E + +AH + ++ + G + +
Sbjct: 423 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
Query: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
AS D TV++W R +L++H V FSPDG+ + S S DK V +W+ S V
Sbjct: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
Query: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
HSY GG + V ++ G + A+ D +V V D+R
Sbjct: 541 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 576
Score = 92.4 bits (228), Expect = 5e-19
Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)
Query: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
ED +L H+ + + ++ + S +D ++W +F H
Sbjct: 317 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 376
Query: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 377 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435
Query: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
+K+W+ ++ + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 436 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
Query: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
C H+ +H V V F P G +A+ D V +W+ ++ L+ Y+ + + + +
Sbjct: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 554
Query: 238 HPSGNYLITASSDSTLKILDL 258
+ G+ + ++SD ++ +LDL
Sbjct: 555 NARGDKVGASASDGSVCVLDL 575
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.131 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,415,133
Number of Sequences: 37866
Number of extensions: 608836
Number of successful extensions: 5952
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 288
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 1325
Number of HSP's gapped (non-prelim): 1901
length of query: 359
length of database: 18,247,518
effective HSP length: 103
effective length of query: 256
effective length of database: 14,347,320
effective search space: 3672913920
effective search space used: 3672913920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.