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Search of human proteins with 118402584
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118402584 F-box and WD repeat domain containing 2 [Homo
sapiens]
(454 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens] 937 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 128 1e-29
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 128 1e-29
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 128 1e-29
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 105 1e-22
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 105 1e-22
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 105 1e-22
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 103 3e-22
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 103 3e-22
gi|32189425 WD repeat domain 69 [Homo sapiens] 93 4e-19
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 87 3e-17
gi|16554629 WD repeat domain 5 [Homo sapiens] 86 5e-17
gi|16554627 WD repeat domain 5 [Homo sapiens] 86 5e-17
gi|23199987 WD repeat domain 5B [Homo sapiens] 82 8e-16
gi|157266266 WD repeat domain 86 [Homo sapiens] 82 1e-15
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 79 1e-14
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 74 2e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 74 4e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 72 8e-13
gi|19913369 transducin beta-like 3 [Homo sapiens] 72 8e-13
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 69 7e-12
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 69 9e-12
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 69 9e-12
gi|21071067 TBP-associated factor 5 [Homo sapiens] 69 1e-11
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 68 2e-11
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 68 2e-11
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 68 2e-11
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 68 2e-11
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 65 1e-10
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 65 2e-10
>gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens]
Length = 454
Score = 937 bits (2423), Expect = 0.0
Identities = 454/454 (100%), Positives = 454/454 (100%)
Query: 1 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL 60
MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL
Sbjct: 1 MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL 60
Query: 61 PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK 120
PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK
Sbjct: 61 PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWK 120
Query: 121 KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC 180
KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC
Sbjct: 121 KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC 180
Query: 181 VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI 240
VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI
Sbjct: 181 VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI 240
Query: 241 LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE 300
LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE
Sbjct: 241 LVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE 300
Query: 301 IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV 360
IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV
Sbjct: 301 IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV 360
Query: 361 IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA 420
IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA
Sbjct: 361 IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA 420
Query: 421 SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 454
SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG
Sbjct: 421 SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG 454
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 128 bits (321), Expect = 1e-29
Identities = 109/440 (24%), Positives = 189/440 (42%), Gaps = 107/440 (24%)
Query: 17 FLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQT 76
F S + +K LD LI Q++H+ +E +RDF+ LLP EL+ Y+L +L+P+
Sbjct: 123 FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD 182
Query: 77 LLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALH---------------WKK 121
LL + W ++++ +W+ CK ++ + + LH WK
Sbjct: 183 LLQAAQTCRYW-RILAEDNLLWREKCK------EEGIDEPLHIKRRKVIKPGFIHSPWKS 235
Query: 122 VYLK-----------AILRMKQLEDHEAFETS---------------------------- 142
Y++ + K L+ H+ +
Sbjct: 236 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKC 295
Query: 143 --SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKFDEQK 198
+L+GH+ V++ +D ++ +GS D + K+W+ TG+C++ + HT + E++
Sbjct: 296 LRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR 355
Query: 199 LVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258
+V+GS D T+ W+ +G GH AV V Y+ +VSG+ DF VKVW
Sbjct: 356 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETE 413
Query: 259 TCLNTLTGHTEWV----------------TKVVLQKCKVKSLLHS------------PGD 290
TCL+TL GHT V T + + + + +H+ D
Sbjct: 414 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD 473
Query: 291 YILLSAD-KYEIKIWPIGREINCKCLKTL---SVSEDRSICLQPRLHFDGKYIVCSSALG 346
IL+S + +KIW I +CL+TL + + CLQ F+ +++ SS G
Sbjct: 474 NILVSGNADSTVKIWDIK---TGQCLQTLQGPNKHQSAVTCLQ----FNKNFVITSSDDG 526
Query: 347 LYQ-WDFASYDILRVIKTPE 365
+ WD + + +R + T E
Sbjct: 527 TVKLWDLKTGEFIRNLVTLE 546
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 128 bits (321), Expect = 1e-29
Identities = 109/440 (24%), Positives = 189/440 (42%), Gaps = 107/440 (24%)
Query: 17 FLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQT 76
F S + +K LD LI Q++H+ +E +RDF+ LLP EL+ Y+L +L+P+
Sbjct: 241 FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD 300
Query: 77 LLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALH---------------WKK 121
LL + W ++++ +W+ CK ++ + + LH WK
Sbjct: 301 LLQAAQTCRYW-RILAEDNLLWREKCK------EEGIDEPLHIKRRKVIKPGFIHSPWKS 353
Query: 122 VYLK-----------AILRMKQLEDHEAFETS---------------------------- 142
Y++ + K L+ H+ +
Sbjct: 354 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKC 413
Query: 143 --SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKFDEQK 198
+L+GH+ V++ +D ++ +GS D + K+W+ TG+C++ + HT + E++
Sbjct: 414 LRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR 473
Query: 199 LVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258
+V+GS D T+ W+ +G GH AV V Y+ +VSG+ DF VKVW
Sbjct: 474 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETE 531
Query: 259 TCLNTLTGHTEWV----------------TKVVLQKCKVKSLLHS------------PGD 290
TCL+TL GHT V T + + + + +H+ D
Sbjct: 532 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD 591
Query: 291 YILLSAD-KYEIKIWPIGREINCKCLKTL---SVSEDRSICLQPRLHFDGKYIVCSSALG 346
IL+S + +KIW I +CL+TL + + CLQ F+ +++ SS G
Sbjct: 592 NILVSGNADSTVKIWDIK---TGQCLQTLQGPNKHQSAVTCLQ----FNKNFVITSSDDG 644
Query: 347 LYQ-WDFASYDILRVIKTPE 365
+ WD + + +R + T E
Sbjct: 645 TVKLWDLKTGEFIRNLVTLE 664
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 128 bits (321), Expect = 1e-29
Identities = 109/440 (24%), Positives = 189/440 (42%), Gaps = 107/440 (24%)
Query: 17 FLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQT 76
F S + +K LD LI Q++H+ +E +RDF+ LLP EL+ Y+L +L+P+
Sbjct: 161 FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD 220
Query: 77 LLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALH---------------WKK 121
LL + W ++++ +W+ CK ++ + + LH WK
Sbjct: 221 LLQAAQTCRYW-RILAEDNLLWREKCK------EEGIDEPLHIKRRKVIKPGFIHSPWKS 273
Query: 122 VYLK-----------AILRMKQLEDHEAFETS---------------------------- 142
Y++ + K L+ H+ +
Sbjct: 274 AYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKC 333
Query: 143 --SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKFDEQK 198
+L+GH+ V++ +D ++ +GS D + K+W+ TG+C++ + HT + E++
Sbjct: 334 LRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR 393
Query: 199 LVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258
+V+GS D T+ W+ +G GH AV V Y+ +VSG+ DF VKVW
Sbjct: 394 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETE 451
Query: 259 TCLNTLTGHTEWV----------------TKVVLQKCKVKSLLHS------------PGD 290
TCL+TL GHT V T + + + + +H+ D
Sbjct: 452 TCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD 511
Query: 291 YILLSAD-KYEIKIWPIGREINCKCLKTL---SVSEDRSICLQPRLHFDGKYIVCSSALG 346
IL+S + +KIW I +CL+TL + + CLQ F+ +++ SS G
Sbjct: 512 NILVSGNADSTVKIWDIK---TGQCLQTLQGPNKHQSAVTCLQ----FNKNFVITSSDDG 564
Query: 347 LYQ-WDFASYDILRVIKTPE 365
+ WD + + +R + T E
Sbjct: 565 TVKLWDLKTGEFIRNLVTLE 584
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 105 bits (261), Expect = 1e-22
Identities = 99/397 (24%), Positives = 178/397 (44%), Gaps = 66/397 (16%)
Query: 4 KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63
K F+ W ++ V F+ +HLIS Q H+++ L+ +L+RDF+ LP +
Sbjct: 78 KYFDQWSESDQVEFV-----------EHLISRMCHYQHGHINSYLKPMLQRDFITALPEQ 126
Query: 64 ----LSFYLLKWLDPQTLLTCCLVSKQWNKVISA-------------CTEVWQTACKNLG 106
++ +L +LD ++L LV K+W +VIS +W+ + G
Sbjct: 127 GLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRG 186
Query: 107 W-------QIDDSVQDALHWKKVYLKAILRMKQLED------HEAFETSSLIGHSARVYA 153
W + D ++ + + +Y K I ++ +E H +S VY
Sbjct: 187 WDQYLFKNRPTDGPPNSFY-RSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYC 245
Query: 154 LYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT--CAAVKFDEQKLVTGSFDNTVACW 211
L Y D + +G D S K+WD ++ +C+ + HT +++DE+ +VTGS D+TV W
Sbjct: 246 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 305
Query: 212 EWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCL---NTLTGHT 268
+ ++G H AV + +++ L +V+ S D ++ VW +++ T + L GH
Sbjct: 306 DVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVLVGHR 363
Query: 269 EWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICL 328
V +++ YI+ ++ IK+W C+ ++TL+ + CL
Sbjct: 364 AAV-----------NVVDFDDKYIVSASGDRTIKVWSTS---TCEFVRTLNGHKRGIACL 409
Query: 329 QPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPE 365
Q R D + SS + WD LRV++ E
Sbjct: 410 QYR---DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 443
Score = 85.9 bits (211), Expect = 7e-17
Identities = 70/247 (28%), Positives = 113/247 (45%), Gaps = 28/247 (11%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAA--VKFDEQKLVT 201
L GH+ V L Y + ++ TGS D + ++WDV+TG+ + + H A ++F +VT
Sbjct: 276 LTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVT 335
Query: 202 GSFDNTVACWEWSSGARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258
S D ++A W+ +S R GH AV VD++D+ +VS S D T+KVW+ S
Sbjct: 336 CSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTC 393
Query: 259 TCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINC-KCLKT 317
+ TL GH + + L ++ + I++W +I C CL+
Sbjct: 394 EFVRTLNGHKRGI-----------ACLQYRDRLVVSGSSDNTIRLW----DIECGACLRV 438
Query: 318 LSVSEDRSICLQPRLHFDGKYIVCSSALG-LYQWDFASYDILRVIKTPEIANLALLGFGD 376
L E+ C++ FD K IV + G + WD + R + + G
Sbjct: 439 LEGHEELVRCIR----FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGR 494
Query: 377 IFALLFD 383
+F L FD
Sbjct: 495 VFRLQFD 501
Score = 65.1 bits (157), Expect = 1e-10
Identities = 37/122 (30%), Positives = 65/122 (53%), Gaps = 13/122 (10%)
Query: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200
+L GH + L Y+D L+ +GS D + +LWD+ G C+ ++ H ++FD +++V
Sbjct: 398 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 457
Query: 201 TGSFDNTVACWEWSSG------ARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVK 251
+G++D + W+ + A T R H+G VF + + DE I +S S D T+
Sbjct: 458 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF-DEFQI-ISSSHDDTIL 515
Query: 252 VW 253
+W
Sbjct: 516 IW 517
Score = 32.3 bits (72), Expect = 0.91
Identities = 18/81 (22%), Positives = 39/81 (48%), Gaps = 11/81 (13%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192
L GH V + + + + +G+ D K+WD+ C+ + H+ +
Sbjct: 439 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRL 498
Query: 193 KFDEQKLVTGSFDNTVACWEW 213
+FDE ++++ S D+T+ W++
Sbjct: 499 QFDEFQIISSSHDDTILIWDF 519
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 105 bits (261), Expect = 1e-22
Identities = 99/397 (24%), Positives = 178/397 (44%), Gaps = 66/397 (16%)
Query: 4 KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63
K F+ W ++ V F+ +HLIS Q H+++ L+ +L+RDF+ LP +
Sbjct: 44 KYFDQWSESDQVEFV-----------EHLISRMCHYQHGHINSYLKPMLQRDFITALPEQ 92
Query: 64 ----LSFYLLKWLDPQTLLTCCLVSKQWNKVISA-------------CTEVWQTACKNLG 106
++ +L +LD ++L LV K+W +VIS +W+ + G
Sbjct: 93 GLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRG 152
Query: 107 W-------QIDDSVQDALHWKKVYLKAILRMKQLED------HEAFETSSLIGHSARVYA 153
W + D ++ + + +Y K I ++ +E H +S VY
Sbjct: 153 WDQYLFKNRPTDGPPNSFY-RSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYC 211
Query: 154 LYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT--CAAVKFDEQKLVTGSFDNTVACW 211
L Y D + +G D S K+WD ++ +C+ + HT +++DE+ +VTGS D+TV W
Sbjct: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 271
Query: 212 EWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCL---NTLTGHT 268
+ ++G H AV + +++ L +V+ S D ++ VW +++ T + L GH
Sbjct: 272 DVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVLVGHR 329
Query: 269 EWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICL 328
V +++ YI+ ++ IK+W C+ ++TL+ + CL
Sbjct: 330 AAV-----------NVVDFDDKYIVSASGDRTIKVWSTS---TCEFVRTLNGHKRGIACL 375
Query: 329 QPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPE 365
Q R D + SS + WD LRV++ E
Sbjct: 376 QYR---DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 409
Score = 85.9 bits (211), Expect = 7e-17
Identities = 70/247 (28%), Positives = 113/247 (45%), Gaps = 28/247 (11%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAA--VKFDEQKLVT 201
L GH+ V L Y + ++ TGS D + ++WDV+TG+ + + H A ++F +VT
Sbjct: 242 LTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVT 301
Query: 202 GSFDNTVACWEWSSGARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258
S D ++A W+ +S R GH AV VD++D+ +VS S D T+KVW+ S
Sbjct: 302 CSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTC 359
Query: 259 TCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINC-KCLKT 317
+ TL GH + + L ++ + I++W +I C CL+
Sbjct: 360 EFVRTLNGHKRGI-----------ACLQYRDRLVVSGSSDNTIRLW----DIECGACLRV 404
Query: 318 LSVSEDRSICLQPRLHFDGKYIVCSSALG-LYQWDFASYDILRVIKTPEIANLALLGFGD 376
L E+ C++ FD K IV + G + WD + R + + G
Sbjct: 405 LEGHEELVRCIR----FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGR 460
Query: 377 IFALLFD 383
+F L FD
Sbjct: 461 VFRLQFD 467
Score = 65.1 bits (157), Expect = 1e-10
Identities = 37/122 (30%), Positives = 65/122 (53%), Gaps = 13/122 (10%)
Query: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200
+L GH + L Y+D L+ +GS D + +LWD+ G C+ ++ H ++FD +++V
Sbjct: 364 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 423
Query: 201 TGSFDNTVACWEWSSG------ARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVK 251
+G++D + W+ + A T R H+G VF + + DE I +S S D T+
Sbjct: 424 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF-DEFQI-ISSSHDDTIL 481
Query: 252 VW 253
+W
Sbjct: 482 IW 483
Score = 32.3 bits (72), Expect = 0.91
Identities = 18/81 (22%), Positives = 39/81 (48%), Gaps = 11/81 (13%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192
L GH V + + + + +G+ D K+WD+ C+ + H+ +
Sbjct: 405 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRL 464
Query: 193 KFDEQKLVTGSFDNTVACWEW 213
+FDE ++++ S D+T+ W++
Sbjct: 465 QFDEFQIISSSHDDTILIWDF 485
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 105 bits (261), Expect = 1e-22
Identities = 99/397 (24%), Positives = 178/397 (44%), Gaps = 66/397 (16%)
Query: 4 KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63
K F+ W ++ V F+ +HLIS Q H+++ L+ +L+RDF+ LP +
Sbjct: 65 KYFDQWSESDQVEFV-----------EHLISRMCHYQHGHINSYLKPMLQRDFITALPEQ 113
Query: 64 ----LSFYLLKWLDPQTLLTCCLVSKQWNKVISA-------------CTEVWQTACKNLG 106
++ +L +LD ++L LV K+W +VIS +W+ + G
Sbjct: 114 GLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRG 173
Query: 107 W-------QIDDSVQDALHWKKVYLKAILRMKQLED------HEAFETSSLIGHSARVYA 153
W + D ++ + + +Y K I ++ +E H +S VY
Sbjct: 174 WDQYLFKNRPTDGPPNSFY-RSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYC 232
Query: 154 LYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT--CAAVKFDEQKLVTGSFDNTVACW 211
L Y D + +G D S K+WD ++ +C+ + HT +++DE+ +VTGS D+TV W
Sbjct: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 292
Query: 212 EWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCL---NTLTGHT 268
+ ++G H AV + +++ L +V+ S D ++ VW +++ T + L GH
Sbjct: 293 DVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVLVGHR 350
Query: 269 EWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICL 328
V +++ YI+ ++ IK+W C+ ++TL+ + CL
Sbjct: 351 AAV-----------NVVDFDDKYIVSASGDRTIKVWSTS---TCEFVRTLNGHKRGIACL 396
Query: 329 QPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPE 365
Q R D + SS + WD LRV++ E
Sbjct: 397 QYR---DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 430
Score = 85.9 bits (211), Expect = 7e-17
Identities = 70/247 (28%), Positives = 113/247 (45%), Gaps = 28/247 (11%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAA--VKFDEQKLVT 201
L GH+ V L Y + ++ TGS D + ++WDV+TG+ + + H A ++F +VT
Sbjct: 263 LTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVT 322
Query: 202 GSFDNTVACWEWSSGARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258
S D ++A W+ +S R GH AV VD++D+ +VS S D T+KVW+ S
Sbjct: 323 CSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTC 380
Query: 259 TCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINC-KCLKT 317
+ TL GH + + L ++ + I++W +I C CL+
Sbjct: 381 EFVRTLNGHKRGI-----------ACLQYRDRLVVSGSSDNTIRLW----DIECGACLRV 425
Query: 318 LSVSEDRSICLQPRLHFDGKYIVCSSALG-LYQWDFASYDILRVIKTPEIANLALLGFGD 376
L E+ C++ FD K IV + G + WD + R + + G
Sbjct: 426 LEGHEELVRCIR----FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGR 481
Query: 377 IFALLFD 383
+F L FD
Sbjct: 482 VFRLQFD 488
Score = 65.1 bits (157), Expect = 1e-10
Identities = 37/122 (30%), Positives = 65/122 (53%), Gaps = 13/122 (10%)
Query: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200
+L GH + L Y+D L+ +GS D + +LWD+ G C+ ++ H ++FD +++V
Sbjct: 385 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 444
Query: 201 TGSFDNTVACWEWSSG------ARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVK 251
+G++D + W+ + A T R H+G VF + + DE I +S S D T+
Sbjct: 445 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF-DEFQI-ISSSHDDTIL 502
Query: 252 VW 253
+W
Sbjct: 503 IW 504
Score = 32.3 bits (72), Expect = 0.91
Identities = 18/81 (22%), Positives = 39/81 (48%), Gaps = 11/81 (13%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192
L GH V + + + + +G+ D K+WD+ C+ + H+ +
Sbjct: 426 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRL 485
Query: 193 KFDEQKLVTGSFDNTVACWEW 213
+FDE ++++ S D+T+ W++
Sbjct: 486 QFDEFQIISSSHDDTILIWDF 506
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 103 bits (257), Expect = 3e-22
Identities = 114/463 (24%), Positives = 184/463 (39%), Gaps = 120/463 (25%)
Query: 4 KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63
K FE W ++ V F+ +HLIS Q H+++ L+ +L+RDF+ LP
Sbjct: 103 KYFEQWSESDQVEFV-----------EHLISQMCHYQHGHINSYLKPMLQRDFITALPAR 151
Query: 64 ----LSFYLLKWLDPQTLLTCCLVSKQWNKVIS-------------ACTEVWQTACKNLG 106
++ +L +LD ++L LV K+W +V S +W+ + G
Sbjct: 152 GLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRG 211
Query: 107 W--------QIDDSVQDALHWKKVYLKAILRMKQLED------------HEAFETSS--- 143
W D + ++ +Y K I ++ +E H ETS
Sbjct: 212 WGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVY 271
Query: 144 -------------------------------LIGHSARVYALYYKDGLLCTGSDDLSAKL 172
L GH+ V L Y + ++ TGS D + ++
Sbjct: 272 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRV 331
Query: 173 WDVSTGQCVYGIQTHTCAAV---KFDEQKLVTGSFDNTVACWEWSSGARTQHFR---GHT 226
WDV+TG+ + + H C AV +F+ +VT S D ++A W+ +S R GH
Sbjct: 332 WDVNTGEMLNTL-IHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHR 390
Query: 227 GAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLH 286
AV VD++D+ +VS S D T+KVW S + TL GH + + L
Sbjct: 391 AAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI-----------ACLQ 437
Query: 287 SPGDYILLSADKYEIKIWPIGREINC-KCLKTLSVSEDRSICLQPRLHFDGKYIVCSSAL 345
++ + I++W +I C CL+ L E+ C++ FD K IV
Sbjct: 438 YRDRLVVSGSSDNTIRLW----DIECGACLRVLEGHEELVRCIR----FDNKRIVS---- 485
Query: 346 GLYQWDFASYDILRVIKTPEIANLALL-----GFGDIFALLFD 383
G Y +D++ + A L G +F L FD
Sbjct: 486 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD 528
Score = 65.1 bits (157), Expect = 1e-10
Identities = 36/122 (29%), Positives = 64/122 (52%), Gaps = 13/122 (10%)
Query: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200
+L GH + L Y+D L+ +GS D + +LWD+ G C+ ++ H ++FD +++V
Sbjct: 425 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 484
Query: 201 TGSFDNTVACWEWSSGARTQHFRG---------HTGAVFSVDYNDELDILVSGSADFTVK 251
+G++D + W+ + + G H+G VF + + DE I VS S D T+
Sbjct: 485 SGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF-DEFQI-VSSSHDDTIL 542
Query: 252 VW 253
+W
Sbjct: 543 IW 544
Score = 32.3 bits (72), Expect = 0.91
Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 11/88 (12%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192
L GH V + + + + +G+ D K+WD+ C+ + H+ +
Sbjct: 466 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 525
Query: 193 KFDEQKLVTGSFDNTVACWEWSSGARTQ 220
+FDE ++V+ S D+T+ W++ + Q
Sbjct: 526 QFDEFQIVSSSHDDTILIWDFLNDPAAQ 553
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 103 bits (257), Expect = 3e-22
Identities = 114/463 (24%), Positives = 184/463 (39%), Gaps = 120/463 (25%)
Query: 4 KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63
K FE W ++ V F+ +HLIS Q H+++ L+ +L+RDF+ LP
Sbjct: 139 KYFEQWSESDQVEFV-----------EHLISQMCHYQHGHINSYLKPMLQRDFITALPAR 187
Query: 64 ----LSFYLLKWLDPQTLLTCCLVSKQWNKVIS-------------ACTEVWQTACKNLG 106
++ +L +LD ++L LV K+W +V S +W+ + G
Sbjct: 188 GLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRG 247
Query: 107 W--------QIDDSVQDALHWKKVYLKAILRMKQLED------------HEAFETSS--- 143
W D + ++ +Y K I ++ +E H ETS
Sbjct: 248 WGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVY 307
Query: 144 -------------------------------LIGHSARVYALYYKDGLLCTGSDDLSAKL 172
L GH+ V L Y + ++ TGS D + ++
Sbjct: 308 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRV 367
Query: 173 WDVSTGQCVYGIQTHTCAAV---KFDEQKLVTGSFDNTVACWEWSSGARTQHFR---GHT 226
WDV+TG+ + + H C AV +F+ +VT S D ++A W+ +S R GH
Sbjct: 368 WDVNTGEMLNTL-IHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHR 426
Query: 227 GAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLH 286
AV VD++D+ +VS S D T+KVW S + TL GH + + L
Sbjct: 427 AAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI-----------ACLQ 473
Query: 287 SPGDYILLSADKYEIKIWPIGREINC-KCLKTLSVSEDRSICLQPRLHFDGKYIVCSSAL 345
++ + I++W +I C CL+ L E+ C++ FD K IV
Sbjct: 474 YRDRLVVSGSSDNTIRLW----DIECGACLRVLEGHEELVRCIR----FDNKRIVS---- 521
Query: 346 GLYQWDFASYDILRVIKTPEIANLALL-----GFGDIFALLFD 383
G Y +D++ + A L G +F L FD
Sbjct: 522 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD 564
Score = 65.1 bits (157), Expect = 1e-10
Identities = 36/122 (29%), Positives = 64/122 (52%), Gaps = 13/122 (10%)
Query: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200
+L GH + L Y+D L+ +GS D + +LWD+ G C+ ++ H ++FD +++V
Sbjct: 461 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 520
Query: 201 TGSFDNTVACWEWSSGARTQHFRG---------HTGAVFSVDYNDELDILVSGSADFTVK 251
+G++D + W+ + + G H+G VF + + DE I VS S D T+
Sbjct: 521 SGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF-DEFQI-VSSSHDDTIL 578
Query: 252 VW 253
+W
Sbjct: 579 IW 580
Score = 32.3 bits (72), Expect = 0.91
Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 11/88 (12%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192
L GH V + + + + +G+ D K+WD+ C+ + H+ +
Sbjct: 502 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 561
Query: 193 KFDEQKLVTGSFDNTVACWEWSSGARTQ 220
+FDE ++V+ S D+T+ W++ + Q
Sbjct: 562 QFDEFQIVSSSHDDTILIWDFLNDPAAQ 589
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 93.2 bits (230), Expect = 4e-19
Identities = 44/130 (33%), Positives = 74/130 (56%), Gaps = 6/130 (4%)
Query: 146 GHSARVYALYY--KDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFD----EQKL 199
GH+A + L + + L+ TGS D +AKLWD+ G+ VY ++ H+ + ++
Sbjct: 175 GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRI 234
Query: 200 VTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGT 259
+TGSFD+TV W+ +G + GH + S +N + ++++GS D T K+W + G
Sbjct: 235 ITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGK 294
Query: 260 CLNTLTGHTE 269
C+ TLTGH +
Sbjct: 295 CVATLTGHDD 304
Score = 80.5 bits (197), Expect = 3e-15
Identities = 52/188 (27%), Positives = 89/188 (47%), Gaps = 21/188 (11%)
Query: 153 ALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDE---QKLVTGSFDNT 207
AL TGS D + KLWD ++G+ + ++ H A+ F+ K+ TGSFD T
Sbjct: 99 ALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKT 158
Query: 208 VACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGH 267
W +G FRGHT + + +N + ++ +GS D T K+W + G + TL GH
Sbjct: 159 CKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGH 218
Query: 268 TEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIW--PIGREIN-----CKCLKTLSV 320
+ + + ++ GD I+ + + + +W GR++N C + + S
Sbjct: 219 SAEI---------ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASF 269
Query: 321 SEDRSICL 328
+ D S+ L
Sbjct: 270 NWDCSLIL 277
Score = 72.8 bits (177), Expect = 6e-13
Identities = 39/132 (29%), Positives = 65/132 (49%), Gaps = 6/132 (4%)
Query: 144 LIGHSARVYALYYK--DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTC----AAVKFDEQ 197
LIGH A + + + L+ TGS D + KLWD + G+CV + H + + +
Sbjct: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
Query: 198 KLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSA 257
+ T S D T + ++ GH G + + +N + + L++GS+D T ++W
Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376
Query: 258 GTCLNTLTGHTE 269
G CL L GHT+
Sbjct: 377 GQCLQVLEGHTD 388
Score = 63.9 bits (154), Expect = 3e-10
Identities = 41/171 (23%), Positives = 79/171 (46%), Gaps = 15/171 (8%)
Query: 140 ETSSLIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTH----TCAAVK 193
E +L GHSA + +L + + TGS D + +WD TG+ V + H + A+
Sbjct: 211 EVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFN 270
Query: 194 FDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
+D ++TGS D T W+ ++G GH + ++ ++ + SAD T +++
Sbjct: 271 WDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF 330
Query: 254 ALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIW 304
+ + C+ L GH ++K+ + G+++L + +IW
Sbjct: 331 SAATRKCIAKLEGHEGEISKI---------SFNPQGNHLLTGSSDKTARIW 372
Score = 63.2 bits (152), Expect = 5e-10
Identities = 35/118 (29%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 142 SSLIGHSARVY--ALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT--CAAVKFDEQ 197
++L GH + Y L+ T S D +A+++ +T +C+ ++ H + + F+ Q
Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ 356
Query: 198 --KLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
L+TGS D T W+ +G Q GHT +FS +N + +I+++GS D T ++W
Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 35.4 bits (80), Expect = 0.11
Identities = 27/106 (25%), Positives = 41/106 (38%), Gaps = 11/106 (10%)
Query: 223 RGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVK 282
+ H + +V N ++GS D T K+W ++G LNTL GH V +
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN----- 143
Query: 283 SLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICL 328
+ GD I + K+W + KC T +CL
Sbjct: 144 ---NPYGDKIATGSFDKTCKLWSVE---TGKCYHTFRGHTAEIVCL 183
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 87.0 bits (214), Expect = 3e-17
Identities = 71/228 (31%), Positives = 104/228 (45%), Gaps = 21/228 (9%)
Query: 142 SSLIGHSARVYALYYK-DG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKF 194
++L GHS V L+Y DG +L + S D + +WD TG+ V ++ HT C +
Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARR 162
Query: 195 DEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWA 254
Q + TGS D TV W+ A Q F+ +T V +V +ND D ++SG D +KVW
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWD 221
Query: 255 LSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIW---PIGREIN 311
L T+ GH + VT + L S G Y+L +A +++W P +
Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLS---------SEGSYLLSNAMDNTVRVWDVRPFAPKER 272
Query: 312 CKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSA-LGLYQWDFASYDIL 358
C + +V L+ DG I SA +Y WD S IL
Sbjct: 273 CVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320
Score = 67.8 bits (164), Expect = 2e-11
Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 11/128 (8%)
Query: 129 RMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQ-TH 187
R+K+L+ H +F S Y L+CTGSDD + KLWD+ + Q T+
Sbjct: 143 RVKRLKGHTSFVNSC--------YPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY 194
Query: 188 TCAAVKFDE--QKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGS 245
AV F++ ++++G DN + W+ T RGH +V + + E L+S +
Sbjct: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNA 254
Query: 246 ADFTVKVW 253
D TV+VW
Sbjct: 255 MDNTVRVW 262
Score = 47.8 bits (112), Expect = 2e-05
Identities = 25/74 (33%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 199 LVTGSFDNTVACWE-WSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSA 257
L + FD + W + +GH+GAV + YN + +L S S D TV VW
Sbjct: 81 LASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSET 140
Query: 258 GTCLNTLTGHTEWV 271
G + L GHT +V
Sbjct: 141 GERVKRLKGHTSFV 154
Score = 35.0 bits (79), Expect = 0.14
Identities = 30/121 (24%), Positives = 53/121 (43%), Gaps = 14/121 (11%)
Query: 141 TSSLIGHSARV--YALYYKDGLLCTGSDDLSAKLWDVST----GQCVYGIQTHTCAAVKF 194
T ++ GH+ V +L + L + + D + ++WDV +CV Q + K
Sbjct: 228 TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN 287
Query: 195 --------DEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSA 246
D K+ GS D V W+ +S GH G++ V ++ + I++S S+
Sbjct: 288 LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347
Query: 247 D 247
D
Sbjct: 348 D 348
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 31/273 (11%)
Query: 143 SLIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA----AVKFDE 196
+L GH+ V ++ + L + S D K+W G+ I H A D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 197 QKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALS 256
LV+ S D T+ W+ SSG + +GH+ VF ++N + +++VSGS D +V++W +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 257 AGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE--IKIWPIGREINCKC 314
G CL TL H++ V S +H D L+ + Y+ +IW + +C
Sbjct: 160 TGKCLKTLPAHSDPV-----------SAVHFNRDGSLIVSSSYDGLCRIWDTA---SGQC 205
Query: 315 LKTLSVSEDRSICLQPRLHFDGKYIVCSSALG-LYQWDFASYDILRVI------KTPEIA 367
LKTL + +D + +GKYI+ ++ L WD++ L+ K A
Sbjct: 206 LKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264
Query: 368 NLALLGFGDIFALLFDNRYLYIMDLRTESLISR 400
N ++ G I + DN +YI +L+T+ ++ +
Sbjct: 265 NFSVTGGKWIVSGSEDN-LVYIWNLQTKEIVQK 296
Score = 58.5 bits (140), Expect = 1e-08
Identities = 47/175 (26%), Positives = 83/175 (47%), Gaps = 23/175 (13%)
Query: 143 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKF-----D 195
+L HS V A+++ +DG L+ + S D ++WD ++GQC+ + V F +
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225
Query: 196 EQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELD---ILVSGSADFTVKV 252
+ ++ + DNT+ W++S G + + GH + + N + +VSGS D V +
Sbjct: 226 GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285
Query: 253 WALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSA---DKYEIKIW 304
W L + L GHT+ V + + H P + I+ SA + IK+W
Sbjct: 286 WNLQTKEIVQKLQGHTDVV---------ISTACH-PTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 31/273 (11%)
Query: 143 SLIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA----AVKFDE 196
+L GH+ V ++ + L + S D K+W G+ I H A D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 197 QKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALS 256
LV+ S D T+ W+ SSG + +GH+ VF ++N + +++VSGS D +V++W +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 257 AGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE--IKIWPIGREINCKC 314
G CL TL H++ V S +H D L+ + Y+ +IW + +C
Sbjct: 160 TGKCLKTLPAHSDPV-----------SAVHFNRDGSLIVSSSYDGLCRIWDTA---SGQC 205
Query: 315 LKTLSVSEDRSICLQPRLHFDGKYIVCSSALG-LYQWDFASYDILRVI------KTPEIA 367
LKTL + +D + +GKYI+ ++ L WD++ L+ K A
Sbjct: 206 LKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264
Query: 368 NLALLGFGDIFALLFDNRYLYIMDLRTESLISR 400
N ++ G I + DN +YI +L+T+ ++ +
Sbjct: 265 NFSVTGGKWIVSGSEDN-LVYIWNLQTKEIVQK 296
Score = 58.5 bits (140), Expect = 1e-08
Identities = 47/175 (26%), Positives = 83/175 (47%), Gaps = 23/175 (13%)
Query: 143 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKF-----D 195
+L HS V A+++ +DG L+ + S D ++WD ++GQC+ + V F +
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225
Query: 196 EQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELD---ILVSGSADFTVKV 252
+ ++ + DNT+ W++S G + + GH + + N + +VSGS D V +
Sbjct: 226 GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285
Query: 253 WALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSA---DKYEIKIW 304
W L + L GHT+ V + + H P + I+ SA + IK+W
Sbjct: 286 WNLQTKEIVQKLQGHTDVV---------ISTACH-PTENIIASAALENDKTIKLW 330
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 82.4 bits (202), Expect = 8e-16
Identities = 71/271 (26%), Positives = 125/271 (46%), Gaps = 27/271 (9%)
Query: 143 SLIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTHTC----AAVKFDE 196
+L+GH+ V ++ + L + S D +W G+ + H A D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 197 QKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALS 256
+LV+ S D T+ W+ SG + +GH+ VF ++N ++++SGS D TVK+W +
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 257 AGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLK 316
G CL TL+ H++ V+ V + G I+ + +IW + +CLK
Sbjct: 156 TGKCLKTLSAHSDPVSAV---------HFNCSGSLIVSGSYDGLCRIWDAA---SGQCLK 203
Query: 317 TLSVSEDRSICLQPRLHFDGKYIVCSSALG-LYQWDFASYDILRVI------KTPEIANL 369
TL V +D + +GKYI+ ++ L WD++ L+ K AN
Sbjct: 204 TL-VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
Query: 370 ALLGFGDIFALLFDNRYLYIMDLRTESLISR 400
++ G I + DN +YI +L+T+ ++ +
Sbjct: 263 SVTGGKWIVSGSEDN-LVYIWNLQTKEIVQK 292
Score = 61.2 bits (147), Expect = 2e-09
Identities = 39/139 (28%), Positives = 68/139 (48%), Gaps = 10/139 (7%)
Query: 143 SLIGHSARVYALYYK--DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKF-----D 195
+L HS V A+++ L+ +GS D ++WD ++GQC+ + V F +
Sbjct: 162 TLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPN 221
Query: 196 EQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELD---ILVSGSADFTVKV 252
+ ++T + DNT+ W++S G + + GH + + N + +VSGS D V +
Sbjct: 222 GKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 281
Query: 253 WALSAGTCLNTLTGHTEWV 271
W L + L GHT+ V
Sbjct: 282 WNLQTKEIVQKLQGHTDVV 300
Score = 45.4 bits (106), Expect = 1e-04
Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 9/102 (8%)
Query: 161 LCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDE---QKLVTGSFDNTVACWEW 213
+ T + D + KLWD S G+C+ H C F + +V+GS DN V W
Sbjct: 225 ILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
Query: 214 SSGARTQHFRGHTGAVFSVDYNDELDILVSGSA--DFTVKVW 253
+ Q +GHT V S + +++ S + D T+K+W
Sbjct: 285 QTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 82.0 bits (201), Expect = 1e-15
Identities = 58/202 (28%), Positives = 87/202 (43%), Gaps = 28/202 (13%)
Query: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAA--VKFDEQKLVT 201
L GH + V +D T S D + + WDV TGQC+ + HT + +L +
Sbjct: 53 LQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFS 112
Query: 202 GSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI--------------LVSGSAD 247
S+D T W G ++ FRGH V ++ Y+ D+ LV+GS D
Sbjct: 113 SSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTD 172
Query: 248 FTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIG 307
T KVW +++G C TL GHT V +VL +PG + I+ W I
Sbjct: 173 GTAKVWQVASGCCHQTLRGHTGAVLCLVLD---------TPGHTAFTGSTDATIRAWDI- 222
Query: 308 REINCKCLKTLSVSEDRSICLQ 329
++ + L+ ICL+
Sbjct: 223 --LSGEQLRVFREHRGSVICLE 242
Score = 79.3 bits (194), Expect = 6e-15
Identities = 44/113 (38%), Positives = 61/113 (53%), Gaps = 6/113 (5%)
Query: 159 GLLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWS 214
GLL TGS D +AK+W V++G C ++ HT C + TGS D T+ W+
Sbjct: 164 GLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDIL 223
Query: 215 SGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGH 267
SG + + FR H G+V ++ + L + SGSAD TVK W G C+ T T H
Sbjct: 224 SGEQLRVFREHRGSVICLELVNRL--VYSGSADRTVKCWLADTGECVRTFTAH 274
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 4/109 (3%)
Query: 147 HSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLVTGSF 204
H V L + L+ +GS D + K W TG+CV H +A+K+ L TGS
Sbjct: 234 HRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSG 293
Query: 205 DNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
D ++ SG + FRGHT + + + + +L + S D +++W
Sbjct: 294 DACARAFDAQSGELRRVFRGHTFIINCIQVHGQ--VLYTASHDGALRLW 340
Score = 49.7 bits (117), Expect = 6e-06
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 2/82 (2%)
Query: 195 DEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWA 254
D Q+L+TGS D T W + G +GH V DE + SAD T++ W
Sbjct: 26 DGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE--AAFTCSADCTIRRWD 83
Query: 255 LSAGTCLNTLTGHTEWVTKVVL 276
+ G CL GHT V ++++
Sbjct: 84 VLTGQCLQVYRGHTSIVNRILV 105
Score = 36.6 bits (83), Expect = 0.048
Identities = 22/68 (32%), Positives = 31/68 (45%), Gaps = 2/68 (2%)
Query: 147 HSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC--VYGIQTHTCAAVKFDEQKLVTGSF 204
H V AL Y G L TGS D A+ +D +G+ V+ T ++ Q L T S
Sbjct: 274 HRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASH 333
Query: 205 DNTVACWE 212
D + W+
Sbjct: 334 DGALRLWD 341
Score = 34.7 bits (78), Expect = 0.18
Identities = 15/48 (31%), Positives = 26/48 (54%)
Query: 225 HTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVT 272
H G + + + + L++GS D T ++W+ + G C L GH +VT
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT 61
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 78.6 bits (192), Expect = 1e-14
Identities = 75/263 (28%), Positives = 104/263 (39%), Gaps = 44/263 (16%)
Query: 111 DSVQDAL--HWKKVYLKAILRMK-QLEDHEAFET-SSLIGHSARV--YALYYKDGLLCTG 164
DSVQD H K+ M +L D + FE ++ GH V A+ + +
Sbjct: 151 DSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA 210
Query: 165 SDDLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQ 220
S D + K+W+V TG CV H D + + S D TV W ++
Sbjct: 211 SRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKA 270
Query: 221 HFRGHTGAVFSVDYNDELD--------------------ILVSGSADFTVKVWALSAGTC 260
R H V + + E L+SGS D T+K+W +S G C
Sbjct: 271 ELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC 330
Query: 261 LNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSV 320
L TL GH WV V L HS G +IL AD +++W N +C+KTL+
Sbjct: 331 LMTLVGHDNWVRGV---------LFHSGGKFILSCADDKTLRVWDYK---NKRCMKTLNA 378
Query: 321 SEDRSICLQPRLHFDGKYIVCSS 343
E L H Y+V S
Sbjct: 379 HEHFVTSLD--FHKTAPYVVTGS 399
Score = 73.2 bits (178), Expect = 5e-13
Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 65/286 (22%)
Query: 140 ETSSLIGHSARVYALYYKD--GLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAA--VKFD 195
E +L GH + V + + ++ + S+D + K+WD TG ++ HT + + FD
Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD 159
Query: 196 E--QKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
+ L + S D T+ W++ + GH V SV D +VS S D T+K+W
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
Query: 254 ALSAGTCLNTLTGHTEWVTK-----------------------VVLQKCKVKSLLH---- 286
+ G C+ T TGH EWV V ++CK + H
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Query: 287 --------------------------SPGDYILLSADKYEIKIWPIGREINCKCLKTLSV 320
PG ++L + IK+W + + CL TL V
Sbjct: 280 ECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM---CLMTL-V 335
Query: 321 SEDRSICLQPRLHFDGKYIV-CSSALGLYQWDFASYDILRVIKTPE 365
D + H GK+I+ C+ L WD+ + ++ + E
Sbjct: 336 GHDNWV-RGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHE 380
Score = 51.2 bits (121), Expect = 2e-06
Identities = 39/173 (22%), Positives = 72/173 (41%), Gaps = 34/173 (19%)
Query: 157 KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTH----------------TCAAVKFDEQK- 198
+DG L+ + S+D + ++W V+T +C ++ H + + E K
Sbjct: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKK 303
Query: 199 -------LVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVK 251
L++GS D T+ W+ S+G GH V V ++ ++S + D T++
Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 252 VWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIW 304
VW C+ TL H +VT + H Y++ + +K+W
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLD---------FHKTAPYVVTGSVDQTVKVW 407
Score = 40.4 bits (93), Expect = 0.003
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 6/76 (7%)
Query: 143 SLIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQK-- 198
+L+GH V + + G + + +DD + ++WD +C+ + H D K
Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA 392
Query: 199 --LVTGSFDNTVACWE 212
+VTGS D TV WE
Sbjct: 393 PYVVTGSVDQTVKVWE 408
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 74.3 bits (181), Expect = 2e-13
Identities = 58/239 (24%), Positives = 103/239 (43%), Gaps = 23/239 (9%)
Query: 163 TGSDDLSAKLWDVSTGQCVYGIQTHTCAA----VKFDEQKLVTGSFDNTVACWEWSSGAR 218
TGS D + K+WD+++G+ + H V L + D V CW+
Sbjct: 221 TGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKV 280
Query: 219 TQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQK 278
+H+ GH AV+ +D + +D+LV+ S D T ++W + ++TL+GHT V V Q
Sbjct: 281 IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQA 340
Query: 279 CKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSED--RSICLQPRLHFDG 336
+ + I+ + I++W + + K TL+ + R++ L PR H+
Sbjct: 341 AEPQ---------IITGSHDTTIRLWDL---VAGKTRVTLTNHKKSVRAVVLHPR-HYT- 386
Query: 337 KYIVCSSALGLYQWDFASYDILRVIKTPE-IANLALLGFGDIFALLFDNRYLYIMDLRT 394
S + QW F ++ + I N + + DN +++ D RT
Sbjct: 387 --FASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRT 443
Score = 58.9 bits (141), Expect = 9e-09
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 7/128 (5%)
Query: 146 GHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAV----KFDEQKL 199
GH + VY L + +L T S D +A++WDV T V+ + HT A + E ++
Sbjct: 286 GHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQI 345
Query: 200 VTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGT 259
+TGS D T+ W+ +G H +V +V + SGS D +K W G+
Sbjct: 346 ITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGS 404
Query: 260 CLNTLTGH 267
+ L+GH
Sbjct: 405 FIQNLSGH 412
Score = 40.8 bits (94), Expect = 0.003
Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 9/83 (10%)
Query: 224 GHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKS 283
GH G V + V+GSAD T+K+W L++G +LTGH V V++
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS------ 255
Query: 284 LLHSPGDYILLSADKYEIKIWPI 306
SP Y+ + ++K W +
Sbjct: 256 -TRSP--YLFSCGEDKQVKCWDL 275
Score = 34.3 bits (77), Expect = 0.24
Identities = 25/117 (21%), Positives = 46/117 (39%), Gaps = 12/117 (10%)
Query: 148 SARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKF---DEQKLVTGSF 204
S R L+ + +GS D + K W G + + H + LV+G+
Sbjct: 374 SVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGAD 432
Query: 205 DNTVACWEWSSGARTQHFRG--------HTGAVFSVDYNDELDILVSGSADFTVKVW 253
+ T+ W+W +G Q +F+ ++ L++ AD T+KV+
Sbjct: 433 NGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
Score = 30.0 bits (66), Expect = 4.5
Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 19/95 (20%)
Query: 130 MKQLEDHEAFETSSLIGHSARVYALYYK-DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT 188
+KQ + + +L GH+A + L DG+L +G+D+ + LWD TG Y Q
Sbjct: 395 IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTG---YNFQRVH 451
Query: 189 CA-------------AVKFD--EQKLVTGSFDNTV 208
A A FD E +L+T D T+
Sbjct: 452 AAVQPGSLDSESGIFACAFDQSESRLLTAEADKTI 486
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 73.6 bits (179), Expect = 4e-13
Identities = 42/177 (23%), Positives = 81/177 (45%), Gaps = 18/177 (10%)
Query: 138 AFETSSLIGHSARVYALYYKDG---LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAA--- 191
A++ ++ H++ V +L LL TG DD LW ++ C+ + HT
Sbjct: 10 AWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESV 69
Query: 192 -VKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTV 250
+ E+ +V GS ++ W+ + + GH + S+D++ + + SGS D +
Sbjct: 70 RLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129
Query: 251 KVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSP-GDYILLSADKYEIKIWPI 306
K+W + C+ GH++ V+ L SP G ++ +AD + +K+W +
Sbjct: 130 KLWDIRRKGCVFRYRGHSQ----------AVRCLRFSPDGKWLASAADDHTVKLWDL 176
Score = 73.6 bits (179), Expect = 4e-13
Identities = 49/183 (26%), Positives = 89/183 (48%), Gaps = 18/183 (9%)
Query: 128 LRMKQLEDHEAFETSSLIGHSARVYALYYKD--GLLCTGSDDLSAKLWDVSTGQCVYGIQ 185
+R+ LE + T L+GH A + +L + + +GS D + KLWD+ CV+ +
Sbjct: 87 IRVWDLEAAKILRT--LMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYR 144
Query: 186 THT----CAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDIL 241
H+ C D + L + + D+TV W+ ++G F GHTG V V+++ +L
Sbjct: 145 GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLL 204
Query: 242 VSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEI 301
SGS+D T++ W L ++ + G + V+S+L +P L S + +
Sbjct: 205 ASGSSDRTIRFWDLEKFQVVSCIEG----------EPGPVRSVLFNPDGCCLYSGCQDSL 254
Query: 302 KIW 304
+++
Sbjct: 255 RVY 257
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 72.4 bits (176), Expect = 8e-13
Identities = 54/189 (28%), Positives = 89/189 (47%), Gaps = 32/189 (16%)
Query: 160 LLCTGSDDLSAKLWDVSTGQCVYGIQTHTC---------AAVKFDEQKLVTGSFDNTVAC 210
++ + S D + +W ++ + YGI + D Q ++GS+D T+
Sbjct: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89
Query: 211 WEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTL--TGHT 268
W+ ++G T+ F GHT V SV ++ + +VSGS D T+K+W + G C T+ H+
Sbjct: 90 WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHS 148
Query: 269 EWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKC----------LKTL 318
EWV+ V ++ S G DK +K+W + NCK L T+
Sbjct: 149 EWVSCVRFSPNSSNPIIVSCG------WDKL-VKVWNLA---NCKLKTNHIGHTGYLNTV 198
Query: 319 SVSEDRSIC 327
+VS D S+C
Sbjct: 199 TVSPDGSLC 207
Score = 55.8 bits (133), Expect = 8e-08
Identities = 49/191 (25%), Positives = 82/191 (42%), Gaps = 22/191 (11%)
Query: 141 TSSLIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKF 194
T +GH+ V ++ + + +GS D + KLW+ + G C Y +Q + + V+F
Sbjct: 98 TRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRF 156
Query: 195 DEQK----LVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTV 250
+V+ +D V W ++ + GHTG + +V + + + SG D
Sbjct: 157 SPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQA 216
Query: 251 KVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREI 310
+W L+ G L TL G + +L SP Y L +A IKIW + +I
Sbjct: 217 MLWDLNEGKHLYTLDGGD-----------IINALCFSPNRYWLCAATGPSIKIWDLEGKI 265
Query: 311 NCKCLKTLSVS 321
LK +S
Sbjct: 266 IVDELKQEVIS 276
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 72.4 bits (176), Expect = 8e-13
Identities = 54/187 (28%), Positives = 78/187 (41%), Gaps = 31/187 (16%)
Query: 157 KDGLLCTGSDDLSAKLWDV-----------STGQCVYGIQTH--------TCAAVKFDEQ 197
K+ L TGS D + KLW + G + QT A+ +++
Sbjct: 433 KESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDK 492
Query: 198 KLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSA 257
L TGS D T W F GH ++ V ++ +L + SAD T+K+WAL
Sbjct: 493 LLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQD 552
Query: 258 GTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKT 317
+CL T GH V KV S G +L S +K+W I N +C++T
Sbjct: 553 FSCLKTFEGHDASVLKVAFV---------SRGTQLLSSGSDGLVKLWTIK---NNECVRT 600
Query: 318 LSVSEDR 324
L ED+
Sbjct: 601 LDAHEDK 607
Score = 61.2 bits (147), Expect = 2e-09
Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 4/123 (3%)
Query: 153 ALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTV 208
A+ D LL TGS D +AKLW + Q + H C +Q L T S D T+
Sbjct: 486 AIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTI 545
Query: 209 ACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHT 268
W + + F GH +V V + L+S +D VK+W + C+ TL H
Sbjct: 546 KLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHE 605
Query: 269 EWV 271
+ V
Sbjct: 606 DKV 608
Score = 57.0 bits (136), Expect = 3e-08
Identities = 57/205 (27%), Positives = 83/205 (40%), Gaps = 31/205 (15%)
Query: 126 AILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVY--- 182
A+LR + ED E + L + +L T S L W G
Sbjct: 56 AVLRSLEQEDQE----------DITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWK 105
Query: 183 GIQTHTCAAVKFDEQK--LVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELD- 239
I T A + FD L TG D V W+ T HFRG G V V ++ +
Sbjct: 106 AIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTR 165
Query: 240 -ILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADK 298
+L S + D ++VW+L +CL LT H VT SL S + +LS+ +
Sbjct: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVT----------SLAFSADGHTMLSSGR 215
Query: 299 YEI-KIWPIGREINCKCLKTLSVSE 322
+I IW + +C+ +T+ V E
Sbjct: 216 DKICIIWDLQ---SCQATRTVPVFE 237
Score = 35.4 bits (80), Expect = 0.11
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 9/117 (7%)
Query: 163 TGSDDLSAKLWDVSTGQCVYGI-------QTHTCAAVKFDEQKLVTGSFDNTVACWEWSS 215
T D + ++W+ ++GQCVY Q T + ++T + D+ + +E S
Sbjct: 264 TAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARS 323
Query: 216 GARTQHFRGHTGAVFSVDY-NDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWV 271
+ F G++ V V + E +V S +KV+ L C L GHT+ V
Sbjct: 324 LRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIV 379
Score = 33.1 bits (74), Expect = 0.53
Identities = 25/122 (20%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 195 DEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWA 254
++ +V S + +E + A Q GHT V ++D + + S + D +V++W
Sbjct: 346 EDSHVVVASNSPCLKVFELQTSA-CQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWR 404
Query: 255 LSAG---TCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREIN 311
++ C+ +GHT V V + K +++ + +K+WP+ + +
Sbjct: 405 MNKAGQVMCVAQGSGHTHSVGTVCCSRLK--------ESFLVTGSQDCTVKLWPLPKALL 456
Query: 312 CK 313
K
Sbjct: 457 SK 458
Score = 33.1 bits (74), Expect = 0.53
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 12/93 (12%)
Query: 128 LRMKQLEDHEAFETSSLIGHSARVYALYYKDG---LLCTGSDDLSAKLWDVSTGQCVYGI 184
+++ L+D +T GH A V + + LL +GSD L KLW + +CV +
Sbjct: 545 IKLWALQDFSCLKTFE--GHDASVLKVAFVSRGTQLLSSGSDGL-VKLWTIKNNECVRTL 601
Query: 185 QTHT-----CAAVKFDEQKLVTGSFDNTVACWE 212
H + D+ L TG+ D+ V W+
Sbjct: 602 DAHEDKVWGLHCSRLDDHAL-TGASDSRVILWK 633
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 69.3 bits (168), Expect = 7e-12
Identities = 55/176 (31%), Positives = 78/176 (44%), Gaps = 21/176 (11%)
Query: 152 YALYYKDGLLCTGSDDLSAKLW--DVSTGQCVYGIQTHTCAAVKF--DEQKLVTGSFDNT 207
Y+LY+ +GS D +A+LW D + +Y VKF + L TGS D T
Sbjct: 395 YSLYF-----ASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 208 VACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGH 267
V W G + F GH G V S+ ++ L S D +K+W L++GT L GH
Sbjct: 450 VRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGH 509
Query: 268 TEWVTKVVLQKCKVKSLLHSPGDYILLSAD-KYEIKIWPIGREINCKCLKTLSVSE 322
T+ +T SL SP ++ SA +++W I R C S SE
Sbjct: 510 TDNIT----------SLTFSPDSGLIASASMDNSVRVWDI-RNTYCSAPADGSSSE 554
Score = 42.0 bits (97), Expect = 0.001
Identities = 68/310 (21%), Positives = 113/310 (36%), Gaps = 66/310 (21%)
Query: 92 SACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKA-ILRMKQLEDHEA-FETSSLIGHSA 149
++C ++W K L S + +++L IL + ED A E L GH
Sbjct: 289 NSCIKLWSLRSKKL-----KSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCG 343
Query: 150 RVYALYY---KDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDN 206
VY+ + GLL S+D+S + WD+ GSF N
Sbjct: 344 PVYSTRFLADSSGLLSC-SEDMSIRYWDL--------------------------GSFTN 376
Query: 207 TVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTG 266
TV ++GH V+ +D + SGS D T ++W+ L G
Sbjct: 377 TVL------------YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAG 424
Query: 267 HTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSI 326
H V V H +Y+ + +++W ++ N L T S+
Sbjct: 425 HLADVDCV---------KFHPNSNYLATGSTDKTVRLWS-AQQGNSVRLFTGHRGPVLSL 474
Query: 327 CLQPRLHFDGKYIVCSSA-LGLYQWDFASYDILRVIK--TPEIANLALLGFGDIFALLFD 383
P +GKY+ + L WD AS + + ++ T I +L + A
Sbjct: 475 AFSP----NGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASM 530
Query: 384 NRYLYIMDLR 393
+ + + D+R
Sbjct: 531 DNSVRVWDIR 540
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 68.9 bits (167), Expect = 9e-12
Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 5/109 (4%)
Query: 160 LLCTGSDDLSAKLWDVSTGQCVYGIQTH-----TCAAVKFDEQKLVTGSFDNTVACWEWS 214
+L TG+ D K+W + +GQC+ + TC + D ++++ SFD T+
Sbjct: 278 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK 337
Query: 215 SGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNT 263
SG + FRGH+ V + + ++S S+D TVK+W + C NT
Sbjct: 338 SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT 386
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/107 (28%), Positives = 52/107 (48%), Gaps = 10/107 (9%)
Query: 182 YGIQTHT-CAAVKFDEQKLVTGSFDNTVACWEWSSGA--------RTQHFRGHTGAVFSV 232
+G ++H CA D Q LVTGS D + W +++G +F AV +
Sbjct: 211 FGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
Query: 233 DYNDELDILVSGSADFTVKVWALSAGTCLNTL-TGHTEWVTKVVLQK 278
++ + ++L +G+ D +KVW + +G CL H++ VT + K
Sbjct: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSK 317
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 68.9 bits (167), Expect = 9e-12
Identities = 57/206 (27%), Positives = 96/206 (46%), Gaps = 31/206 (15%)
Query: 141 TSSLIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKF---- 194
TSSL GHS V ++ + L +GS D + + WD+ST + + H +
Sbjct: 107 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP 166
Query: 195 DEQKLVTGSFDNTVACWEWSSGART-QHFRGHTGAVFSVDY-----NDELDILVSGSADF 248
D +KL +G + + W+ S+G + + GH+ + + + N E + S S D
Sbjct: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
Query: 249 TVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADK-YEIKIWPIG 307
+V++W +AG C LTGHT+ VT L GD +L SA + IK+W
Sbjct: 227 SVRIWDTTAGRCERILTGHTQSVT-----------CLRWGGDGLLYSASQDRTIKVWRAH 275
Query: 308 REINCKCLK-------TLSVSEDRSI 326
+ C+ L+ T+++S D ++
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYAL 301
Score = 60.8 bits (146), Expect = 2e-09
Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 5/119 (4%)
Query: 161 LCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKF-----DEQKLVTGSFDNTVACWEWSS 215
L +GSDD + LW + + T A + D + + + SFD ++ W+ +
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403
Query: 216 GARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKV 274
G RGH AV+ + ++ + +LVSGS+D T+KVW + A L GH + V V
Sbjct: 404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 462
Score = 57.8 bits (138), Expect = 2e-08
Identities = 31/116 (26%), Positives = 58/116 (50%), Gaps = 6/116 (5%)
Query: 144 LIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKF----DEQ 197
+ GH A + + + ++ + S D S KLWD TG+ + ++ H A + D +
Sbjct: 368 MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSR 427
Query: 198 KLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
LV+GS D+T+ W+ + GH V++VD++ + + SG D +++W
Sbjct: 428 LLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 68.6 bits (166), Expect = 1e-11
Identities = 49/184 (26%), Positives = 77/184 (41%), Gaps = 21/184 (11%)
Query: 133 LEDHEAFETSSLIGHSARVYALYYKD--GLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA 190
+++ A E L GHS VY + L + S+D + +LW + T C+ G + H
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587
Query: 191 AVKFDEQ------KLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSG 244
+D Q V+G D W + F GH V ++ + + +G
Sbjct: 588 V--WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATG 645
Query: 245 SADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSP-GDYILLSADKYEIKI 303
SAD TV++W + G C+ TGH K + SL SP G ++ A + +
Sbjct: 646 SADRTVRLWDVLNGNCVRIFTGH----------KGPIHSLTFSPNGRFLATGATDGRVLL 695
Query: 304 WPIG 307
W IG
Sbjct: 696 WDIG 699
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/134 (32%), Positives = 61/134 (45%), Gaps = 12/134 (8%)
Query: 146 GHSARVYALYY--KDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKL 199
GH A V + + TGS D + +LWDV G CV H + + L
Sbjct: 625 GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFL 684
Query: 200 VTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW-ALSAG 258
TG+ D V W+ G +GHT V S+ ++ + +IL SGS D TV++W A+ A
Sbjct: 685 ATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAF 744
Query: 259 TCL-----NTLTGH 267
L T TGH
Sbjct: 745 EDLETDDFTTATGH 758
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 67.8 bits (164), Expect = 2e-11
Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 14/157 (8%)
Query: 153 ALYYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQK----LVTGSFDNT 207
A + DG L+ + SDD + KLWD S+ +CV+ H D + DNT
Sbjct: 113 AKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT 172
Query: 208 VACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGH 267
V W+ + QH++ H+ AV + ++ + L++ S+D T+K+ L G L TL GH
Sbjct: 173 VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 232
Query: 268 TEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIW 304
T V + G+Y ++ +W
Sbjct: 233 QGPATTVAFSR---------TGEYFASGGSDEQVMVW 260
Score = 56.2 bits (134), Expect = 6e-08
Identities = 43/170 (25%), Positives = 74/170 (43%), Gaps = 15/170 (8%)
Query: 140 ETSSLIGHSARVYALYY-KDGL-LCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVK 193
E++ H+A V ++++ DG T SDD + K+W + ++ + H CA
Sbjct: 57 ESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFS 116
Query: 194 FDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
D + +V+ S D TV W+ SS + H G V VD++ + + D TVKVW
Sbjct: 117 PDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
Query: 254 ALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKI 303
+ L H+ V + H G+Y++ ++ +KI
Sbjct: 177 DVRTHRLLQHYQLHSAAVNGL---------SFHPSGNYLITASSDSTLKI 217
Score = 53.1 bits (126), Expect = 5e-07
Identities = 40/142 (28%), Positives = 57/142 (40%), Gaps = 13/142 (9%)
Query: 167 DLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHF 222
D +W + Y H TC L +GS D TV W + + F
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 223 RGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVK 282
R HT V SV + + V+ S D TVKVWA L +L+ H WV +C
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV------RC--- 112
Query: 283 SLLHSPGDYILLSADKYEIKIW 304
+ G I+ ++D +K+W
Sbjct: 113 AKFSPDGRLIVSASDDKTVKLW 134
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 67.8 bits (164), Expect = 2e-11
Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 14/157 (8%)
Query: 153 ALYYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQK----LVTGSFDNT 207
A + DG L+ + SDD + KLWD S+ +CV+ H D + DNT
Sbjct: 151 AKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT 210
Query: 208 VACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGH 267
V W+ + QH++ H+ AV + ++ + L++ S+D T+K+ L G L TL GH
Sbjct: 211 VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270
Query: 268 TEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIW 304
T V + G+Y ++ +W
Sbjct: 271 QGPATTVAFSR---------TGEYFASGGSDEQVMVW 298
Score = 56.6 bits (135), Expect = 5e-08
Identities = 43/156 (27%), Positives = 68/156 (43%), Gaps = 14/156 (8%)
Query: 188 TCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSAD 247
TC + ++L +GS D+ + W +R F GH AV V+++ +L SGS D
Sbjct: 23 TCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRD 82
Query: 248 FTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIG 307
TV++W + HT V V C S G + ++D +K+W
Sbjct: 83 KTVRIWVPNVKGESTVFRAHTATVRSV--HFC-------SDGQSFVTASDDKTVKVWATH 133
Query: 308 REINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSS 343
R+ K L +LS + C + DG+ IV +S
Sbjct: 134 RQ---KFLFSLSQHINWVRC--AKFSPDGRLIVSAS 164
Score = 56.2 bits (134), Expect = 6e-08
Identities = 43/170 (25%), Positives = 74/170 (43%), Gaps = 15/170 (8%)
Query: 140 ETSSLIGHSARVYALYY-KDGL-LCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVK 193
E++ H+A V ++++ DG T SDD + K+W + ++ + H CA
Sbjct: 95 ESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFS 154
Query: 194 FDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
D + +V+ S D TV W+ SS + H G V VD++ + + D TVKVW
Sbjct: 155 PDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
Query: 254 ALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKI 303
+ L H+ V + H G+Y++ ++ +KI
Sbjct: 215 DVRTHRLLQHYQLHSAAVNGL---------SFHPSGNYLITASSDSTLKI 255
Score = 42.4 bits (98), Expect = 9e-04
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 11/86 (12%)
Query: 220 QHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKC 279
+HF+GH AV VD++ L SGS D + VW + + TGH + VT V
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF--- 69
Query: 280 KVKSLLHSPGDYILLSADKYE-IKIW 304
SP ++L S + + ++IW
Sbjct: 70 -------SPSGHLLASGSRDKTVRIW 88
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 67.8 bits (164), Expect = 2e-11
Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 14/157 (8%)
Query: 153 ALYYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQK----LVTGSFDNT 207
A + DG L+ + SDD + KLWD S+ +CV+ H D + DNT
Sbjct: 151 AKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT 210
Query: 208 VACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGH 267
V W+ + QH++ H+ AV + ++ + L++ S+D T+K+ L G L TL GH
Sbjct: 211 VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270
Query: 268 TEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIW 304
T V + G+Y ++ +W
Sbjct: 271 QGPATTVAFSR---------TGEYFASGGSDEQVMVW 298
Score = 56.6 bits (135), Expect = 5e-08
Identities = 43/156 (27%), Positives = 68/156 (43%), Gaps = 14/156 (8%)
Query: 188 TCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSAD 247
TC + ++L +GS D+ + W +R F GH AV V+++ +L SGS D
Sbjct: 23 TCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRD 82
Query: 248 FTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIG 307
TV++W + HT V V C S G + ++D +K+W
Sbjct: 83 KTVRIWVPNVKGESTVFRAHTATVRSV--HFC-------SDGQSFVTASDDKTVKVWATH 133
Query: 308 REINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSS 343
R+ K L +LS + C + DG+ IV +S
Sbjct: 134 RQ---KFLFSLSQHINWVRC--AKFSPDGRLIVSAS 164
Score = 56.2 bits (134), Expect = 6e-08
Identities = 43/170 (25%), Positives = 74/170 (43%), Gaps = 15/170 (8%)
Query: 140 ETSSLIGHSARVYALYY-KDGL-LCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVK 193
E++ H+A V ++++ DG T SDD + K+W + ++ + H CA
Sbjct: 95 ESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFS 154
Query: 194 FDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
D + +V+ S D TV W+ SS + H G V VD++ + + D TVKVW
Sbjct: 155 PDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
Query: 254 ALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKI 303
+ L H+ V + H G+Y++ ++ +KI
Sbjct: 215 DVRTHRLLQHYQLHSAAVNGL---------SFHPSGNYLITASSDSTLKI 255
Score = 42.4 bits (98), Expect = 9e-04
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 11/86 (12%)
Query: 220 QHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKC 279
+HF+GH AV VD++ L SGS D + VW + + TGH + VT V
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF--- 69
Query: 280 KVKSLLHSPGDYILLSADKYE-IKIW 304
SP ++L S + + ++IW
Sbjct: 70 -------SPSGHLLASGSRDKTVRIW 88
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 67.8 bits (164), Expect = 2e-11
Identities = 89/371 (23%), Positives = 145/371 (39%), Gaps = 73/371 (19%)
Query: 54 RDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQW------------------NKVI---- 91
RDF++ LP+ LS Y+L+ LD TL C VS+ W N++
Sbjct: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
Query: 92 SACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLED----HEAFETSSLIGH 147
S + + + V D + + K LR K + ++ ET ++
Sbjct: 335 SYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLME 394
Query: 148 SARVY-----------------ALYYKDGLLCTGSDDLSAKLWDVSTGQCV----YGIQT 186
V+ ++Y G L S + L D+ + + G
Sbjct: 395 ERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAG 454
Query: 187 HTCAAVKFDEQKLV-TGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGS 245
A +E+ + +GS+D ++ W+ SG T+ F GH G + +D + LVSG
Sbjct: 455 SVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK--NRLVSGG 512
Query: 246 ADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWP 305
D VKVW + G CL T H + + + YI+ S ++ +K+W
Sbjct: 513 RDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-----------DTYIVSSCERGLVKVWH 560
Query: 306 IGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQ-WDF-ASYD-ILRVIK 362
I + +KTLS E C L FD +++ S GL W Y+ L K
Sbjct: 561 IAM---AQLVKTLSGHEGAVKC----LFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK 613
Query: 363 TP-EIANLALL 372
P E+ +++LL
Sbjct: 614 HPKEVLDVSLL 624
Score = 56.6 bits (135), Expect = 5e-08
Identities = 48/183 (26%), Positives = 80/183 (43%), Gaps = 31/183 (16%)
Query: 222 FRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKV 281
FRGH G+V ++ +E + L+SGS D +++ W L +G C GH +T + L K ++
Sbjct: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRL 508
Query: 282 KSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVC 341
S ++K+W + KCLKT + L R+ + YIV
Sbjct: 509 VS-----------GGRDCQVKVWDVD---TGKCLKTF---RHKDPILATRI--NDTYIVS 549
Query: 342 SSALGLYQ-WDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISR 400
S GL + W A +++ + E G + L FD +L + T+ L+
Sbjct: 550 SCERGLVKVWHIAMAQLVKTLSGHE---------GAVKCLFFDQWHL--LSGSTDGLVMA 598
Query: 401 WPL 403
W +
Sbjct: 599 WSM 601
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 65.5 bits (158), Expect = 1e-10
Identities = 47/176 (26%), Positives = 69/176 (39%), Gaps = 51/176 (28%)
Query: 143 SLIGHSARVYALYY--KDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH-----TCAAVK-- 193
+L GH A++YA+++ LL + S D +WD T V+ I TCA
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 194 ------------------------------------------FDEQKLVTGSFDNTVACW 211
D+ ++VT S D T A W
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169
Query: 212 EWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGH 267
+ +G +T F GHTG V S+ + + VSG+ D + K+W + G C T TGH
Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/167 (24%), Positives = 70/167 (41%), Gaps = 14/167 (8%)
Query: 144 LIGHSARVYAL-YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKF----DEQK 198
L GH+ + + D + T S D + LWD+ TGQ HT + D +
Sbjct: 139 LAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL 198
Query: 199 LVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258
V+G+ D + W+ G Q F GH + ++ + + +GS D T +++ L A
Sbjct: 199 FVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD 258
Query: 259 TCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSA-DKYEIKIW 304
L T + H + C + S+ S +LL+ D + +W
Sbjct: 259 QELMTYS-HDNII-------CGITSVSFSKSGRLLLAGYDDFNCNVW 297
Score = 42.7 bits (99), Expect = 7e-04
Identities = 38/142 (26%), Positives = 58/142 (40%), Gaps = 10/142 (7%)
Query: 140 ETSSLIGHSARVYALYYKDG--LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF- 194
+T++ GH+ V +L L +G+ D SAKLWDV G C H A+ F
Sbjct: 176 QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF 235
Query: 195 -DEQKLVTGSFDNTVACWEWSSGARTQHFRGHTG---AVFSVDYNDELDILVSGSADFTV 250
+ TGS D T ++ + + H + SV ++ +L++G DF
Sbjct: 236 PNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLAGYDDFNC 294
Query: 251 KVWALSAGTCLNTLTGHTEWVT 272
VW L GH V+
Sbjct: 295 NVWDALKADRAGVLAGHDNRVS 316
Score = 37.0 bits (84), Expect = 0.037
Identities = 29/116 (25%), Positives = 47/116 (40%), Gaps = 8/116 (6%)
Query: 146 GHSARVYAL-YYKDG-LLCTGSDDLSAKLWDVSTGQ--CVYGIQTHTCAAVKFDEQK--- 198
GH + + A+ ++ +G TGSDD + +L+D+ Q Y C K
Sbjct: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR 283
Query: 199 -LVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 253
L+ G D W+ R GH V + D+ + +GS D +K+W
Sbjct: 284 LLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 64.7 bits (156), Expect = 2e-10
Identities = 60/228 (26%), Positives = 102/228 (44%), Gaps = 26/228 (11%)
Query: 137 EAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAV 192
+ FE L +A+ A + + TG+DD+ ++++ +T + V+ + H+ C AV
Sbjct: 51 KTFEVCDLPVRAAKFVA---RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAV 107
Query: 193 KFDEQKLVTGSFDNTVACWEWSSG-ARTQHFRGHTGAVFSVDYND-ELDILVSGSADFTV 250
+ ++T S D + W+W + +Q F GHT V + N + + S S D T+
Sbjct: 108 HPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTI 167
Query: 251 KVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGD--YILLSADKYEIKIWPIGR 308
KVW L + + TL GH + V + +S GD Y++ AD +KIW
Sbjct: 168 KVWQLGSSSPNFTLEGHEKGVNCID---------YYSGGDKPYLISGADDRLVKIWDYQ- 217
Query: 309 EINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQ-WDFASY 355
N C++TL C H + I+ S G + W ++Y
Sbjct: 218 --NKTCVQTLEGHAQNVSCAS--FHPELPIIITGSEDGTVRIWHSSTY 261
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/108 (25%), Positives = 50/108 (46%), Gaps = 6/108 (5%)
Query: 163 TGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFD------EQKLVTGSFDNTVACWEWSSG 216
+ S D + K+W + + + ++ H D + L++G+ D V W++ +
Sbjct: 160 SASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNK 219
Query: 217 ARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTL 264
Q GH V ++ EL I+++GS D TV++W S +TL
Sbjct: 220 TCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTL 267
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,267,940
Number of Sequences: 37866
Number of extensions: 725508
Number of successful extensions: 3155
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 1561
Number of HSP's gapped (non-prelim): 982
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.