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Search of human proteins with 11761621
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11761621 GDP-mannose pyrophosphorylase B isoform 2 [Homo
sapiens]
(360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11761621 GDP-mannose pyrophosphorylase B isoform 2 [Homo sapi... 724 0.0
gi|11761619 GDP-mannose pyrophosphorylase B isoform 1 [Homo sapi... 710 0.0
gi|31881779 GDP-mannose pyrophosphorylase A [Homo sapiens] 201 6e-52
gi|45447090 GDP-mannose pyrophosphorylase A [Homo sapiens] 201 6e-52
gi|9966779 eukaryotic translation initiation factor 2B, subunit ... 48 2e-05
gi|83267879 eukaryotic translation initiation factor 2B, subunit... 32 0.68
gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Hom... 30 4.4
gi|126352608 elastin isoform e precursor [Homo sapiens] 28 9.8
gi|126352446 elastin isoform d precursor [Homo sapiens] 28 9.8
gi|126352322 elastin isoform c precursor [Homo sapiens] 28 9.8
gi|126352700 elastin isoform b precursor [Homo sapiens] 28 9.8
gi|126352440 elastin isoform a precursor [Homo sapiens] 28 9.8
gi|241982802 HMG box domain containing 3 [Homo sapiens] 28 9.8
gi|189027121 solute carrier family 35, member F1 [Homo sapiens] 28 9.8
>gi|11761621 GDP-mannose pyrophosphorylase B isoform 2 [Homo
sapiens]
Length = 360
Score = 724 bits (1870), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL 60
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL
Sbjct: 1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL 60
Query: 61 EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM
Sbjct: 61 EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
Query: 121 VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP 180
VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP
Sbjct: 121 VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP 180
Query: 181 AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ 240
AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ
Sbjct: 181 AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ 240
Query: 241 PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH 300
PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH
Sbjct: 241 PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH 300
Query: 301 SWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM 360
SWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM
Sbjct: 301 SWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM 360
>gi|11761619 GDP-mannose pyrophosphorylase B isoform 1 [Homo
sapiens]
Length = 387
Score = 710 bits (1832), Expect = 0.0
Identities = 360/387 (93%), Positives = 360/387 (93%), Gaps = 27/387 (6%)
Query: 1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL 60
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL
Sbjct: 1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL 60
Query: 61 EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM
Sbjct: 61 EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
Query: 121 VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP 180
VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP
Sbjct: 121 VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP 180
Query: 181 AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ 240
AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ
Sbjct: 181 AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ 240
Query: 241 PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH 300
PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH
Sbjct: 241 PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH 300
Query: 301 SWLESCIVGWRCRVGQW---------------------------VRMENVTVLGEDVIVN 333
SWLESCIVGWRCRVGQW VRMENVTVLGEDVIVN
Sbjct: 301 SWLESCIVGWRCRVGQWVSLWAGLGGERGGECACLPDKAYPLLEVRMENVTVLGEDVIVN 360
Query: 334 DELYLNGASVLPHKSIGESVPEPRIIM 360
DELYLNGASVLPHKSIGESVPEPRIIM
Sbjct: 361 DELYLNGASVLPHKSIGESVPEPRIIM 387
>gi|31881779 GDP-mannose pyrophosphorylase A [Homo sapiens]
Length = 420
Score = 201 bits (512), Expect = 6e-52
Identities = 133/412 (32%), Positives = 199/412 (48%), Gaps = 60/412 (14%)
Query: 1 MKALILVGG--YGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA-GVDHVILAVSYM- 56
+KA+IL+GG GTR RPL+ PKPL P++ H +EA A G+ ++L Y
Sbjct: 2 LKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQP 61
Query: 57 SQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARD-LLSETADPFFVLNSDVICDF 115
+ L + ++A +Q + + E PLGT G L RD +L+ + + FFVLN+DV DF
Sbjct: 62 DEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDF 121
Query: 116 PFQAMVQFHRHHGQEGSILVTKVEEPSK--YGVVVCEADTGRIHRFVEKPQVFVSNKINA 173
P AM++ HR +L T YG +V T + +VEKP F+S+ IN
Sbjct: 122 PLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINC 181
Query: 174 GMYILSPAVLRRI-----------QLQPTS----------IEKEVFPIMAKEGQLYAMEL 212
G+Y+ SP L+ + QL+ + +E++VF +A +GQ+Y
Sbjct: 182 GIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLT 241
Query: 213 QGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCS----GPGIVGNVLVDPSARIGQNCSI 268
G W I L L+L + PERL GP I GNV + P+A++ + +
Sbjct: 242 DGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVL 301
Query: 269 GPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVRMEN------ 322
GPNVS+G GV V +GV +R VL A ++ H+ + IVGW VG+W R+E
Sbjct: 302 GPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPN 361
Query: 323 ----------------------VTVLGEDVIVNDELYLNGASVLPHKSIGES 352
+T+LG V + E+ + + VLPHK + S
Sbjct: 362 PNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRS 413
>gi|45447090 GDP-mannose pyrophosphorylase A [Homo sapiens]
Length = 420
Score = 201 bits (512), Expect = 6e-52
Identities = 133/412 (32%), Positives = 199/412 (48%), Gaps = 60/412 (14%)
Query: 1 MKALILVGG--YGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA-GVDHVILAVSYM- 56
+KA+IL+GG GTR RPL+ PKPL P++ H +EA A G+ ++L Y
Sbjct: 2 LKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQP 61
Query: 57 SQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARD-LLSETADPFFVLNSDVICDF 115
+ L + ++A +Q + + E PLGT G L RD +L+ + + FFVLN+DV DF
Sbjct: 62 DEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDF 121
Query: 116 PFQAMVQFHRHHGQEGSILVTKVEEPSK--YGVVVCEADTGRIHRFVEKPQVFVSNKINA 173
P AM++ HR +L T YG +V T + +VEKP F+S+ IN
Sbjct: 122 PLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINC 181
Query: 174 GMYILSPAVLRRI-----------QLQPTS----------IEKEVFPIMAKEGQLYAMEL 212
G+Y+ SP L+ + QL+ + +E++VF +A +GQ+Y
Sbjct: 182 GIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLT 241
Query: 213 QGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCS----GPGIVGNVLVDPSARIGQNCSI 268
G W I L L+L + PERL GP I GNV + P+A++ + +
Sbjct: 242 DGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVL 301
Query: 269 GPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVRMEN------ 322
GPNVS+G GV V +GV +R VL A ++ H+ + IVGW VG+W R+E
Sbjct: 302 GPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPN 361
Query: 323 ----------------------VTVLGEDVIVNDELYLNGASVLPHKSIGES 352
+T+LG V + E+ + + VLPHK + S
Sbjct: 362 PNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRS 413
>gi|9966779 eukaryotic translation initiation factor 2B, subunit 3
gamma [Homo sapiens]
Length = 452
Score = 47.8 bits (112), Expect = 2e-05
Identities = 35/140 (25%), Positives = 71/140 (50%), Gaps = 7/140 (5%)
Query: 2 KALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLE 61
+A+++ G G+R+ LT S PKPL+ NKP++ + + L G + VI+ ++ ++
Sbjct: 4 QAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVT---TRDVQ 60
Query: 62 KEMKAQ-EQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
K + A+ + ++ I ++ +GTA L R + + VL+ D+I D +
Sbjct: 61 KALCAEFKMKMKPDIVCIPDDADMGTADSL---RYIYPKLKTDVLVLSCDLITDVALHEV 117
Query: 121 VQFHRHHGQEGSILVTKVEE 140
V R + ++L+ K ++
Sbjct: 118 VDLFRAYDASLAMLMRKGQD 137
Score = 29.6 bits (65), Expect = 4.4
Identities = 19/76 (25%), Positives = 36/76 (47%), Gaps = 5/76 (6%)
Query: 262 IGQNCSIGPNVS-----LGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQ 316
IG +C I V+ L V VE+G I+ + +A I + ++ C++G R+
Sbjct: 375 IGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSVICNNAVIEKGADIKDCLIGSGQRIEA 434
Query: 317 WVRMENVTVLGEDVIV 332
+ N ++G D ++
Sbjct: 435 KAKRVNEVIVGNDQLM 450
>gi|83267879 eukaryotic translation initiation factor 2B, subunit 5
epsilon, 82kDa [Homo sapiens]
Length = 721
Score = 32.3 bits (72), Expect = 0.68
Identities = 25/93 (26%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 269 GPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVRMENVTVLGE 328
GP VSLG G ++E+ V + TV I S+ ++ + ++G C +G V ++ T L +
Sbjct: 345 GPEVSLGHGSILEENVLLGSGTV-----IGSNCFITNSVIGPGCHIGDNVVLDQ-TYLWQ 398
Query: 329 DVIVNDELYLNGASVLPHKSIGESVP-EPRIIM 360
V V ++ + + + + E V +PR ++
Sbjct: 399 GVRVAAGAQIHQSLLCDNAEVKERVTLKPRSVL 431
>gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Homo
sapiens]
Length = 453
Score = 29.6 bits (65), Expect = 4.4
Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 3/47 (6%)
Query: 110 DVICDFPFQAMV---QFHRHHGQEGSILVTKVEEPSKYGVVVCEADT 153
DV+CD P+Q ++ F ++ GQE S ++ + P V DT
Sbjct: 78 DVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDT 124
>gi|126352608 elastin isoform e precursor [Homo sapiens]
Length = 705
Score = 28.5 bits (62), Expect = 9.8
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 249 GIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGV 284
G+V V V P + + P V L PGV V GV
Sbjct: 453 GLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGV 488
>gi|126352446 elastin isoform d precursor [Homo sapiens]
Length = 711
Score = 28.5 bits (62), Expect = 9.8
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 249 GIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGV 284
G+V V V P + + P V L PGV V GV
Sbjct: 477 GLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGV 512
>gi|126352322 elastin isoform c precursor [Homo sapiens]
Length = 692
Score = 28.5 bits (62), Expect = 9.8
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 249 GIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGV 284
G+V V V P + + P V L PGV V GV
Sbjct: 458 GLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGV 493
>gi|126352700 elastin isoform b precursor [Homo sapiens]
Length = 677
Score = 28.5 bits (62), Expect = 9.8
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 249 GIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGV 284
G+V V V P + + P V L PGV V GV
Sbjct: 443 GLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGV 478
>gi|126352440 elastin isoform a precursor [Homo sapiens]
Length = 724
Score = 28.5 bits (62), Expect = 9.8
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 249 GIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGV 284
G+V V V P + + P V L PGV V GV
Sbjct: 472 GLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGV 507
>gi|241982802 HMG box domain containing 3 [Homo sapiens]
Length = 1292
Score = 28.5 bits (62), Expect = 9.8
Identities = 50/207 (24%), Positives = 82/207 (39%), Gaps = 27/207 (13%)
Query: 163 PQVFVSNKINAGMYILSPAVLRRIQLQPTSIEKEVFPIMAKEGQLYAM--ELQGFWMDIG 220
PQ ++ KI+ +LS A R L+ +EKE +K L A+ ++ GF I
Sbjct: 68 PQSEINKKISESWRLLSVAE-RSYYLEKAKLEKEGLDPNSKLSALTAVVPDIPGF-RKIL 125
Query: 221 QPKDFLTGMCLFLQSLRQKQPERLC--------SGPGIVGNVL---VDPSARIGQNCSIG 269
D++ LQ R LC GP +V N V A + + C
Sbjct: 126 PRSDYIIIPKSSLQEDRSCPQLELCVAQNQMSPKGPPLVSNTAPETVPSHAGMAEQCLAV 185
Query: 270 PNVSLGPGVVVEDGVC--IRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVRMENVTVLG 327
++ G + + G I +L + + LE VG+ + +++
Sbjct: 186 EALAEEVGALTQSGAVQEIATSEILSQDVLLEDASLE---------VGESHQPYQTSLVI 236
Query: 328 EDVIVNDELYL-NGASVLPHKSIGESV 353
E+ +VN L G+ +PH +GESV
Sbjct: 237 EETLVNGSPDLPTGSLAVPHPQVGESV 263
>gi|189027121 solute carrier family 35, member F1 [Homo sapiens]
Length = 408
Score = 28.5 bits (62), Expect = 9.8
Identities = 16/46 (34%), Positives = 24/46 (52%)
Query: 306 CIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGE 351
CI+G C VG V + GE+ +V D L L GA++ ++ E
Sbjct: 192 CILGMGCMVGADVLVGRHQGAGENKLVGDLLVLGGATLYGISNVWE 237
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,508,569
Number of Sequences: 37866
Number of extensions: 662353
Number of successful extensions: 1273
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1210
Number of HSP's gapped (non-prelim): 37
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.