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Search of human proteins with 11761619
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11761619 GDP-mannose pyrophosphorylase B isoform 1 [Homo
sapiens]
(387 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11761619 GDP-mannose pyrophosphorylase B isoform 1 [Homo sapi... 783 0.0
gi|11761621 GDP-mannose pyrophosphorylase B isoform 2 [Homo sapi... 710 0.0
gi|31881779 GDP-mannose pyrophosphorylase A [Homo sapiens] 200 2e-51
gi|45447090 GDP-mannose pyrophosphorylase A [Homo sapiens] 200 2e-51
gi|9966779 eukaryotic translation initiation factor 2B, subunit ... 48 2e-05
gi|83267879 eukaryotic translation initiation factor 2B, subunit... 39 0.010
gi|4505749 phosphofructokinase, muscle [Homo sapiens] 30 3.7
gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Hom... 30 4.8
>gi|11761619 GDP-mannose pyrophosphorylase B isoform 1 [Homo
sapiens]
Length = 387
Score = 783 bits (2021), Expect = 0.0
Identities = 387/387 (100%), Positives = 387/387 (100%)
Query: 1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL 60
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL
Sbjct: 1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL 60
Query: 61 EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM
Sbjct: 61 EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
Query: 121 VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP 180
VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP
Sbjct: 121 VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP 180
Query: 181 AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ 240
AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ
Sbjct: 181 AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ 240
Query: 241 PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH 300
PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH
Sbjct: 241 PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH 300
Query: 301 SWLESCIVGWRCRVGQWVSLWAGLGGERGGECACLPDKAYPLLEVRMENVTVLGEDVIVN 360
SWLESCIVGWRCRVGQWVSLWAGLGGERGGECACLPDKAYPLLEVRMENVTVLGEDVIVN
Sbjct: 301 SWLESCIVGWRCRVGQWVSLWAGLGGERGGECACLPDKAYPLLEVRMENVTVLGEDVIVN 360
Query: 361 DELYLNGASVLPHKSIGESVPEPRIIM 387
DELYLNGASVLPHKSIGESVPEPRIIM
Sbjct: 361 DELYLNGASVLPHKSIGESVPEPRIIM 387
>gi|11761621 GDP-mannose pyrophosphorylase B isoform 2 [Homo
sapiens]
Length = 360
Score = 710 bits (1832), Expect = 0.0
Identities = 360/387 (93%), Positives = 360/387 (93%), Gaps = 27/387 (6%)
Query: 1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL 60
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL
Sbjct: 1 MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL 60
Query: 61 EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM
Sbjct: 61 EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
Query: 121 VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP 180
VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP
Sbjct: 121 VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP 180
Query: 181 AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ 240
AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ
Sbjct: 181 AVLRRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ 240
Query: 241 PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH 300
PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH
Sbjct: 241 PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH 300
Query: 301 SWLESCIVGWRCRVGQWVSLWAGLGGERGGECACLPDKAYPLLEVRMENVTVLGEDVIVN 360
SWLESCIVGWRCRVGQW VRMENVTVLGEDVIVN
Sbjct: 301 SWLESCIVGWRCRVGQW---------------------------VRMENVTVLGEDVIVN 333
Query: 361 DELYLNGASVLPHKSIGESVPEPRIIM 387
DELYLNGASVLPHKSIGESVPEPRIIM
Sbjct: 334 DELYLNGASVLPHKSIGESVPEPRIIM 360
>gi|31881779 GDP-mannose pyrophosphorylase A [Homo sapiens]
Length = 420
Score = 200 bits (508), Expect = 2e-51
Identities = 132/412 (32%), Positives = 202/412 (49%), Gaps = 33/412 (8%)
Query: 1 MKALILVGG--YGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA-GVDHVILAVSYM- 56
+KA+IL+GG GTR RPL+ PKPL P++ H +EA A G+ ++L Y
Sbjct: 2 LKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQP 61
Query: 57 SQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARD-LLSETADPFFVLNSDVICDF 115
+ L + ++A +Q + + E PLGT G L RD +L+ + + FFVLN+DV DF
Sbjct: 62 DEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDF 121
Query: 116 PFQAMVQFHRHHGQEGSILVTKVEEPSK--YGVVVCEADTGRIHRFVEKPQVFVSNKINA 173
P AM++ HR +L T YG +V T + +VEKP F+S+ IN
Sbjct: 122 PLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINC 181
Query: 174 GMYILSPAVLRRI-----------QLQPTS----------IEKEVFPIMAKEGQLYAMEL 212
G+Y+ SP L+ + QL+ + +E++VF +A +GQ+Y
Sbjct: 182 GIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLT 241
Query: 213 QGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCS----GPGIVGNVLVDPSARIGQNCSI 268
G W I L L+L + PERL GP I GNV + P+A++ + +
Sbjct: 242 DGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVL 301
Query: 269 GPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVSLWAGLGGER 328
GPNVS+G GV V +GV +R VL A ++ H+ + IVGW VG+W +
Sbjct: 302 GPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPN 361
Query: 329 GGECACLPDKAYPLLEVR-MENVTVLGEDVIVNDELYLNGASVLPHKSIGES 379
+ D + + + +T+LG V + E+ + + VLPHK + S
Sbjct: 362 PNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRS 413
>gi|45447090 GDP-mannose pyrophosphorylase A [Homo sapiens]
Length = 420
Score = 200 bits (508), Expect = 2e-51
Identities = 132/412 (32%), Positives = 202/412 (49%), Gaps = 33/412 (8%)
Query: 1 MKALILVGG--YGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA-GVDHVILAVSYM- 56
+KA+IL+GG GTR RPL+ PKPL P++ H +EA A G+ ++L Y
Sbjct: 2 LKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQP 61
Query: 57 SQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARD-LLSETADPFFVLNSDVICDF 115
+ L + ++A +Q + + E PLGT G L RD +L+ + + FFVLN+DV DF
Sbjct: 62 DEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDF 121
Query: 116 PFQAMVQFHRHHGQEGSILVTKVEEPSK--YGVVVCEADTGRIHRFVEKPQVFVSNKINA 173
P AM++ HR +L T YG +V T + +VEKP F+S+ IN
Sbjct: 122 PLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINC 181
Query: 174 GMYILSPAVLRRI-----------QLQPTS----------IEKEVFPIMAKEGQLYAMEL 212
G+Y+ SP L+ + QL+ + +E++VF +A +GQ+Y
Sbjct: 182 GIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLT 241
Query: 213 QGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCS----GPGIVGNVLVDPSARIGQNCSI 268
G W I L L+L + PERL GP I GNV + P+A++ + +
Sbjct: 242 DGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVL 301
Query: 269 GPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVSLWAGLGGER 328
GPNVS+G GV V +GV +R VL A ++ H+ + IVGW VG+W +
Sbjct: 302 GPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPN 361
Query: 329 GGECACLPDKAYPLLEVR-MENVTVLGEDVIVNDELYLNGASVLPHKSIGES 379
+ D + + + +T+LG V + E+ + + VLPHK + S
Sbjct: 362 PNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRS 413
>gi|9966779 eukaryotic translation initiation factor 2B, subunit 3
gamma [Homo sapiens]
Length = 452
Score = 47.8 bits (112), Expect = 2e-05
Identities = 35/140 (25%), Positives = 71/140 (50%), Gaps = 7/140 (5%)
Query: 2 KALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLE 61
+A+++ G G+R+ LT S PKPL+ NKP++ + + L G + VI+ ++ ++
Sbjct: 4 QAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVT---TRDVQ 60
Query: 62 KEMKAQ-EQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM 120
K + A+ + ++ I ++ +GTA L R + + VL+ D+I D +
Sbjct: 61 KALCAEFKMKMKPDIVCIPDDADMGTADSL---RYIYPKLKTDVLVLSCDLITDVALHEV 117
Query: 121 VQFHRHHGQEGSILVTKVEE 140
V R + ++L+ K ++
Sbjct: 118 VDLFRAYDASLAMLMRKGQD 137
>gi|83267879 eukaryotic translation initiation factor 2B, subunit 5
epsilon, 82kDa [Homo sapiens]
Length = 721
Score = 38.5 bits (88), Expect = 0.010
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 12/110 (10%)
Query: 269 GPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWV-----SLWAG 323
GP VSLG G ++E+ V + TV I S+ ++ + ++G C +G V LW G
Sbjct: 345 GPEVSLGHGSILEENVLLGSGTV-----IGSNCFITNSVIGPGCHIGDNVVLDQTYLWQG 399
Query: 324 LGGERGGEC--ACLPDKAYPLLEVRMENVTVLGEDVIVNDELYLNGASVL 371
+ G + + L D A V ++ +VL V+V + L SV+
Sbjct: 400 VRVAAGAQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPNITLPEGSVI 449
>gi|4505749 phosphofructokinase, muscle [Homo sapiens]
Length = 780
Score = 30.0 bits (66), Expect = 3.7
Identities = 17/79 (21%), Positives = 33/79 (41%), Gaps = 5/79 (6%)
Query: 309 GWRCRVGQWVSLWAGLGGERGGECACLPDKAYPLLEVRMENVTVLGEDVIVNDELYLNGA 368
GW +V W G GG + G LP K++ + + + G +I E Y G
Sbjct: 452 GW-----SYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGL 506
Query: 369 SVLPHKSIGESVPEPRIIM 387
++ + + + P +++
Sbjct: 507 ELMEGRKQFDELCIPFVVI 525
>gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Homo
sapiens]
Length = 453
Score = 29.6 bits (65), Expect = 4.8
Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 3/47 (6%)
Query: 110 DVICDFPFQAMV---QFHRHHGQEGSILVTKVEEPSKYGVVVCEADT 153
DV+CD P+Q ++ F ++ GQE S ++ + P V DT
Sbjct: 78 DVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDT 124
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,869,496
Number of Sequences: 37866
Number of extensions: 737870
Number of successful extensions: 1424
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1391
Number of HSP's gapped (non-prelim): 14
length of query: 387
length of database: 18,247,518
effective HSP length: 104
effective length of query: 283
effective length of database: 14,309,454
effective search space: 4049575482
effective search space used: 4049575482
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.