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Search of human proteins with 10835203
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10835203 advanced glycosylation end product-specific
receptor isoform 1 precursor [Homo sapiens]
(404 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10835203 advanced glycosylation end product-specific receptor... 826 0.0
gi|26787962 advanced glycosylation end product-specific receptor... 530 e-151
gi|68163411 activated leukocyte cell adhesion molecule [Homo sap... 82 9e-16
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 78 2e-14
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 78 2e-14
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 78 2e-14
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 74 2e-13
gi|109150416 peroxidasin [Homo sapiens] 73 5e-13
gi|224994173 roundabout 1 isoform d [Homo sapiens] 72 9e-13
gi|224994171 roundabout 1 isoform c [Homo sapiens] 72 9e-13
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 72 9e-13
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 72 9e-13
gi|19743806 roundabout 1 isoform b [Homo sapiens] 70 3e-12
gi|71274107 melanoma cell adhesion molecule [Homo sapiens] 70 3e-12
gi|4506569 roundabout 1 isoform a [Homo sapiens] 70 3e-12
gi|169214048 PREDICTED: hypothetical protein [Homo sapiens] 69 1e-11
gi|89057602 PREDICTED: hypothetical protein [Homo sapiens] 69 1e-11
gi|37551995 PREDICTED: hypothetical protein [Homo sapiens] 69 1e-11
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 67 4e-11
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 67 4e-11
gi|118572606 hemicentin 1 [Homo sapiens] 65 8e-11
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 65 1e-10
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 65 1e-10
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 64 3e-10
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens] 62 1e-09
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 61 2e-09
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 61 2e-09
gi|15147240 brother of CDO [Homo sapiens] 61 2e-09
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 60 4e-09
gi|21686977 cell adhesion molecule 4 [Homo sapiens] 60 5e-09
>gi|10835203 advanced glycosylation end product-specific receptor
isoform 1 precursor [Homo sapiens]
Length = 404
Score = 826 bits (2133), Expect = 0.0
Identities = 404/404 (100%), Positives = 404/404 (100%)
Query: 1 MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA
Sbjct: 1 MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
Query: 61 WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 120
WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI
Sbjct: 61 WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 120
Query: 121 PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH 180
PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH
Sbjct: 121 PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH 180
Query: 181 PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL 240
PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL
Sbjct: 181 PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL 240
Query: 241 VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYS 300
VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYS
Sbjct: 241 VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYS 300
Query: 301 CVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGV 360
CVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGV
Sbjct: 301 CVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGV 360
Query: 361 ILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP 404
ILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
Sbjct: 361 ILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP 404
>gi|26787962 advanced glycosylation end product-specific receptor
isoform 2 precursor [Homo sapiens]
Length = 342
Score = 530 bits (1365), Expect = e-151
Identities = 260/274 (94%), Positives = 260/274 (94%), Gaps = 14/274 (5%)
Query: 1 MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKL
Sbjct: 1 MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKL------- 53
Query: 61 WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 120
GGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI
Sbjct: 54 -------GGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 106
Query: 121 PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH 180
PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH
Sbjct: 107 PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH 166
Query: 181 PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL 240
PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL
Sbjct: 167 PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL 226
Query: 241 VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 274
VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD
Sbjct: 227 VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD 260
Score = 32.3 bits (72), Expect = 0.78
Identities = 18/57 (31%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 252 GGTVTLTCE-VPAQPSPQIHWMKDGVPLP----LPPSPVLILPEIGPQDQGTYSCVA 303
G + L C+ P +P ++ W G P + P+ L LP +G QD+G + C A
Sbjct: 31 GEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQA 87
>gi|68163411 activated leukocyte cell adhesion molecule [Homo
sapiens]
Length = 583
Score = 82.0 bits (201), Expect = 9e-16
Identities = 65/223 (29%), Positives = 100/223 (44%), Gaps = 6/223 (2%)
Query: 81 NGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK 140
N +L + I DE F C + + V+V++ P KPEIV A L K
Sbjct: 95 NYTLSISNARISDEKRFVCMLVTEDNVFEAPTI-VKVFKQPSKPEIVSKALFLETEQLKK 153
Query: 141 VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGG 200
+G C+SE SYP G ++W+ +GK L P E V + + P T L+T+ S L +
Sbjct: 154 LGDCISEDSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTK-A 212
Query: 201 DPRPTFSCSFSPGLPRHRALRTAPIQPRVWE-PVPLEEVQLVVEPEGGAVAPGGTVTLTC 259
D + F+CS + P + +T + V++ P E+V + V P A+ G +TL C
Sbjct: 213 DIQMPFTCSVTYYGPSGQ--KTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKC 270
Query: 260 EVPAQPSP-QIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSC 301
P P + + G P + S L ++ G Y C
Sbjct: 271 LGNGNPPPEEFLFYLPGQPEGIRSSNTYTLTDVRRNATGDYKC 313
Score = 36.6 bits (83), Expect = 0.042
Identities = 42/157 (26%), Positives = 60/157 (38%), Gaps = 17/157 (10%)
Query: 252 GGTVTLTCEVPAQPSPQIHWMKDG---VPLPLPPSPVL-------ILPEIGPQDQGTYSC 301
G + T+ C V P P I W G V SP + I+ I P++ T +C
Sbjct: 428 GLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKII--ISPEENVTLTC 485
Query: 302 VATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLA-LALGILGGLGTAALLIGV 360
A + S VS I +E + A L +GI+ GL AAL+ GV
Sbjct: 486 TAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAALVAGV 545
Query: 361 ILW----QRRQRRGEERKAPENQEEEEERAELNQSEE 393
+ W + + K N EE ++ E N E
Sbjct: 546 VYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTE 582
Score = 31.2 bits (69), Expect = 1.7
Identities = 18/70 (25%), Positives = 30/70 (42%), Gaps = 5/70 (7%)
Query: 233 VPLEEVQLVVEPEGGAVAP-GGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEI 291
+ + + L + P G G + ++C + A + + WMKD + L PS +
Sbjct: 327 ITVHYLDLSLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPS----FSSL 382
Query: 292 GPQDQGTYSC 301
QD G Y C
Sbjct: 383 HYQDAGNYVC 392
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 77.8 bits (190), Expect = 2e-14
Identities = 86/304 (28%), Positives = 124/304 (40%), Gaps = 53/304 (17%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVG 90
G+ + L C+ A +PP + W L G SP G + L GSL L +
Sbjct: 2041 GQEVRLDCE-ADGQPPPDVAW-LKDG--------SPLGQDMGPHLRFYLDGGSLVLKGLR 2090
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT--CVSEG 148
D G + C A N G++ + + V V P + D + L + P ++ T C G
Sbjct: 2091 ASDAGAYTCVAHNPAGEDARL-HTVNVLVPPTIKQGADGSGTLVSR-PGELVTMVCPVRG 2148
Query: 149 SYPAGTLSWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 202
S P +SW DG PL +++ G +++ + + G+FT + +PA D
Sbjct: 2149 SPPIH-VSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC---VAASPAGVADR 2204
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
T P V EPV + +VV G V L CE
Sbjct: 2205 NFTLQVQVPP----------------VLEPVEFQNDVVVVR--------GSLVELPCEAR 2240
Query: 263 AQPSPQIHWMKDGVPL---PLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSIS 319
P P + WMKDG PL L P L L +G D GTYSCVA S + R ++
Sbjct: 2241 GVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAV--SEAGEARRHFQLT 2298
Query: 320 IIEP 323
++EP
Sbjct: 2299 VMEP 2302
Score = 73.9 bits (180), Expect = 2e-13
Identities = 92/328 (28%), Positives = 127/328 (38%), Gaps = 62/328 (18%)
Query: 25 NITARIGEPLVLKCK--GAPK------KPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVA 76
N+T P +L C+ G+PK K Q+L+++L G
Sbjct: 2581 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG------------------AY 2622
Query: 77 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAG 136
R+LP+ +L L A G QD F C N G E Y+V V+ +P P I D ++ T
Sbjct: 2623 RLLPSNALLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVH-VP--PTIADDQTDFTVT 2678
Query: 137 VPNKVG-TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
+ V TC S G PA T+SW G L G V +G + L
Sbjct: 2679 MMAPVVLTCHSTG-IPAPTVSWSKAGAQLGARGSGYRVS-------PSGALEIGQAL--- 2727
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTV 255
P G R T S S G+ T P V +P+P V+ V E E V
Sbjct: 2728 PIHAG--RYTCSARNSAGVAHKHVFLTVQASP-VVKPLP-SVVRAVAEEE---------V 2774
Query: 256 TLTCEVPAQPSPQIHWMKD------GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHG 309
L CE P P I W K+ GV + P L + P+D G Y C+A +S+
Sbjct: 2775 LLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834
Query: 310 PQESRAVSISIIEPGEEG-PTAGSVGGS 336
+ + + E G P + GS
Sbjct: 2835 AMGKTRLVVQVPPVIENGLPDLSTTEGS 2862
Score = 70.9 bits (172), Expect = 2e-12
Identities = 89/346 (25%), Positives = 138/346 (39%), Gaps = 53/346 (15%)
Query: 11 VLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGG 70
+LVL ++ + G +++ R+G+ L L+C A P R+ W +N + +S Q GG
Sbjct: 2934 ILVLPVFTTLPGDRSL--RLGDRLWLRC-AARGSPTPRIGWTVND--RPVTEGVSEQDGG 2988
Query: 71 PWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSA 130
+L AV +D G + C A NR G+ ++ V V + P ++
Sbjct: 2989 -----------STLQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG--EAF 3034
Query: 131 SELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ 189
S L V + CV G P + W DG PL +G ++ Q LQ
Sbjct: 3035 SYLVEPVGGSIQLDCVVRGD-PVPDIHWIKDGLPL----RGSHLRHQ-----------LQ 3078
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
+ + D + C L + + V + P+ +V EP+ V
Sbjct: 3079 NGSLTIHRTERDDAGRYQC-----LAENEMGVAKKVVILVLQSAPVFQV----EPQDMTV 3129
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLP------PSPVLILPEIGPQDQGTYSCVA 303
G V L C+ +P+P I W++ G PL P L L + D GTY CVA
Sbjct: 3130 RSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 3189
Query: 304 THSSHGPQESRAVSISIIEP-GEEGPTAGSVGGSGLGTLALALGIL 348
H+ G +RA + EP G G G + G G L ++
Sbjct: 3190 -HNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVM 3234
Score = 62.0 bits (149), Expect = 9e-10
Identities = 80/327 (24%), Positives = 125/327 (38%), Gaps = 86/327 (26%)
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS----ELTAGVP 138
SL L AVG D G + C A++ G E + ++++ V + P I DS LT G P
Sbjct: 2266 SLQLEAVGAGDSGTYSCVAVSEAG-EARRHFQLTVME---PPHIEDSGQPTELSLTPGAP 2321
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE------- 191
++ C ++G+ P ++WH DG+ L E S + R + GL+T +E
Sbjct: 2322 MEL-LCDAQGT-PQPNITWHKDGQALTRLENN-SRATRVLRVRDAGLYTCLAESPAGAIE 2378
Query: 192 ------LMVTPARGGDPRPTFSCSFSPG-LPRHRALRTAPIQPRVW--EPVPLEEVQLVV 242
+ P G P F +PG L ++ P W + + L+E
Sbjct: 2379 KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQ 2438
Query: 243 EPEGGA------------------------------------------------VAPGGT 254
PE G V+ T
Sbjct: 2439 FPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQT 2498
Query: 255 VTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVL-ILPE-------IGPQDQGTYSCVATHS 306
L C+ P+P + W KD VPL P SP ILPE + QD G Y C+A++S
Sbjct: 2499 ALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2557
Query: 307 SHGPQESRAVSISIIEPGEEGPTAGSV 333
+ ++ R + ++EP P+ ++
Sbjct: 2558 AGSDRQGR--DLRVLEPPAIAPSPSNL 2582
Score = 58.9 bits (141), Expect = 8e-09
Identities = 73/312 (23%), Positives = 123/312 (39%), Gaps = 50/312 (16%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPN 81
G+ + +R GE + + C PP + W + G P R L +
Sbjct: 2128 GSGTLVSRPGELVTMVCP-VRGSPPIHVSWL--------------KDGLPLPLSQRTLLH 2172
Query: 82 GS---LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 138
GS L + V + D GIF C A + G + N+ ++V Q+P E V+ +++
Sbjct: 2173 GSGHTLRISKVQLADAGIFTCVAASPAGVADR-NFTLQV-QVPPVLEPVEFQNDVVVVRG 2230
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPN--EKGVSVKEQTRRHPETGLFTLQSELMVTP 196
+ V P +SW DG+PL+ E+G S++ + ++G ++ V
Sbjct: 2231 SLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC-----VAV 2285
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
+ G+ R F Q V EP +E+ +P ++ PG +
Sbjct: 2286 SEAGEARRHF-------------------QLTVMEPPHIEDSG---QPTELSLTPGAPME 2323
Query: 257 LTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAV 316
L C+ P P I W KDG L + + +D G Y+C+A + ++S V
Sbjct: 2324 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2383
Query: 317 SISIIEPGEEGP 328
+ P GP
Sbjct: 2384 RVQ-APPNIVGP 2394
Score = 58.2 bits (139), Expect = 1e-08
Identities = 83/336 (24%), Positives = 132/336 (39%), Gaps = 60/336 (17%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ R+G+ VL C+ P +K A + + +GG L
Sbjct: 1851 VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ------------RLE 1898
Query: 86 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK--VGT 143
+ + D+G++ C+ N G+ ++ + + V Q+P P + +E + V V T
Sbjct: 1899 IQEAQVSDKGLYSCKVSNVAGEAVRT-FTLTV-QVP--PTFENPKTETVSQVAGSPLVLT 1954
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPR 203
C G PA T++W D P+ + +V R L LQ PA+ G
Sbjct: 1955 CDVSG-VPAPTVTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQ------PAQAG--- 2000
Query: 204 PTFSC--SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
T++C + R + + PR+ E V G V L CE
Sbjct: 2001 -TYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH---------VLEGQEVRLDCEA 2050
Query: 262 PAQPSPQIHWMKDGVPLPLPPSP---------VLILPEIGPQDQGTYSCVATHSSHGPQE 312
QP P + W+KDG PL P L+L + D G Y+CVA H+ G ++
Sbjct: 2051 DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA-HNPAG-ED 2108
Query: 313 SRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGIL 348
+R +++++ P PT G G GTL G L
Sbjct: 2109 ARLHTVNVLVP----PTI-KQGADGSGTLVSRPGEL 2139
Score = 57.0 bits (136), Expect = 3e-08
Identities = 76/319 (23%), Positives = 117/319 (36%), Gaps = 43/319 (13%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSL 84
NITA + PL L C+ A PP + W + P + + L
Sbjct: 1170 NITAALHSPLTLLCE-AMGIPPPAIRW-----------FRGEEPVSPGEDTYLLAGGWML 1217
Query: 85 FLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGT 143
+ QD G++ C A N G E + N+ V V P + E ++ ++ G +
Sbjct: 1218 KMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 1276
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKG-VSVKEQTRRHPETGLFTLQSELMVTPARGGDP 202
V+ +P L+W DG+PL + +S + + L + + G+
Sbjct: 1277 NVT--GHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1334
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
F S + AP E EEV + V ++L CE
Sbjct: 1335 TKHFQLS----------VLLAPTILGGAEDSADEEVTVTVN---------NPISLICEAL 1375
Query: 263 AQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRA 315
A PSP I WMKDG P LP + L + +D G Y+CV T+ ++
Sbjct: 1376 AFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYH 1435
Query: 316 VSISIIEPGEEGPTAGSVG 334
V + I + G VG
Sbjct: 1436 VEVLIPPSISKDDPLGEVG 1454
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/247 (22%), Positives = 103/247 (41%), Gaps = 33/247 (13%)
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE-LTAGVPNKV 141
+L L + D G++ C+A+N G++ K ++ V P + + + V +K
Sbjct: 1801 TLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 1859
Query: 142 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
+ P T++W+ DG+PLV ++ +++ R L + A+ D
Sbjct: 1860 VLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR-------------LEIQEAQVSD 1906
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQ-PRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCE 260
+ +SC S T +Q P +E E V V G + LTC+
Sbjct: 1907 -KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA---------GSPLVLTCD 1956
Query: 261 VPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
V P+P + W+KD +P+ + L L + P GTY+CVA ++ ++
Sbjct: 1957 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKD 2016
Query: 314 RAVSISI 320
V++ +
Sbjct: 2017 FVVAVLV 2023
Score = 56.2 bits (134), Expect = 5e-08
Identities = 74/323 (22%), Positives = 121/323 (37%), Gaps = 43/323 (13%)
Query: 11 VLVLSLWGAVVGAQ-NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGG 69
VL + + +++G + N++ E + L+C+ PP WK GR L P+ G
Sbjct: 873 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK--DGRP-----LEPRPG 925
Query: 70 GPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS 129
V L + + D G + C+A+N+ G+ K +Y + V+ P P
Sbjct: 926 -----VHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEK-HYNLNVWVAPVFPLRESH 979
Query: 130 ASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ 189
+ G P + +C G P +SW DG+PL G+ R L+ Q
Sbjct: 980 TLTVREGHPTSL-SCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRL----LYLGQ 1033
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
++L + T CS G + P++ P P +V
Sbjct: 1034 AQL------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE--------PPTQVSV 1079
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLP-------PSPVLILPEIGPQDQGTYSCV 302
G TL C +P P + W +DG P+ L + G YSCV
Sbjct: 1080 VQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCV 1139
Query: 303 ATHSSHGPQESRAVSISIIEPGE 325
A + + + R +S++ P E
Sbjct: 1140 AENLA--GRAERKFELSVLVPPE 1160
Score = 55.8 bits (133), Expect = 7e-08
Identities = 82/285 (28%), Positives = 109/285 (38%), Gaps = 53/285 (18%)
Query: 32 EPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWD-SVARVLPNGSLFLPAVG 90
+P V + GA KPP E W G P VA LP L + V
Sbjct: 617 DPPVHRGWGAHPKPPL----------VEGWCSPGSLWGEPTGIPVAYSLPP-PLQIEKVD 665
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGTCVSEGS 149
++DEGI+ C A N G E+K ++V P +P V+ A A V + C++ G
Sbjct: 666 LRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLE---CLASG- 720
Query: 150 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 209
P +SW +P V + GV+V R L + A+ D ++ C
Sbjct: 721 VPPPDVSWFKGHQP-VSSWMGVTVSVDGR------------VLRIEQAQLSDAG-SYRCV 766
Query: 210 FS--PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP 267
S G R + PR+ P L LV P V LTC PSP
Sbjct: 767 ASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP----------VRLTCNATGAPSP 816
Query: 268 QIHWMKDGVPLP---------LPPSPVLILPEIGPQDQGTYSCVA 303
+ W+KDG P+ P VL L D G YSCVA
Sbjct: 817 TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVA 861
Score = 51.2 bits (121), Expect = 2e-06
Identities = 75/281 (26%), Positives = 103/281 (36%), Gaps = 45/281 (16%)
Query: 77 RVLPNGS-LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA 135
+V P G L L + D G + C A++ G++ + V Q+ P I+ ++
Sbjct: 836 QVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV----VLQVHMPPSILGEELNVSV 891
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
V + P LSW DG+PL P P L ++ L V
Sbjct: 892 VANESVALECQSHAMPPPVLSWWKDGRPLEPR-------------PGVHLSADKALLQVD 938
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVW-EPV-PLEEVQLVVEPEGGAVAPGG 253
A D ++C R VW PV PL E + V G
Sbjct: 939 RADVWDAGH-YTCEALNQAGRSEKHYNL----NVWVAPVFPLRESHTLT------VREGH 987
Query: 254 TVTLTCEVPAQPSPQIHWMKDGVPLP---------LPPSPVLILPEIGPQDQGTYSC--- 301
+L+CE P P+I W KDG PLP +L L + +GTY+C
Sbjct: 988 PTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS 1047
Query: 302 -VATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTL 341
V +SS Q V I P E PT SV G+ TL
Sbjct: 1048 NVVGNSSQDLQLEVHVPPQIAGP-REPPTQVSVVQDGVATL 1087
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/311 (24%), Positives = 125/311 (40%), Gaps = 51/311 (16%)
Query: 2 AAGTAVGAWVLVLSLWGAVV-GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
+AG+A+G LV+ + + G +++ G L CK A P + W
Sbjct: 2831 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK-ARGSPEPNITWD-------- 2881
Query: 61 WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 120
K P G + + P+G L + + QD G + C A N G+ + RV + I
Sbjct: 2882 -KDGQPVSGA--EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR---RVHL-TI 2934
Query: 121 PGKPEIVDSASELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRR 179
P + + + +++ C + GS P + W ++ +P+ +GVS ++
Sbjct: 2935 LVLPVFTTLPGDRSLRLGDRLWLRCAARGS-PTPRIGWTVNDRPVT---EGVSEQD---- 2986
Query: 180 HPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEV- 238
G TLQ + G T+ C + R +A+ ++ PV E
Sbjct: 2987 ----GGSTLQRAAVSREDSG-----TYVCWAENRVGRTQAVSFVHVKEA---PVLQGEAF 3034
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPL------PLPPSPVLILPEIG 292
+VEP GG++ L C V P P IHW+KDG+PL + L +
Sbjct: 3035 SYLVEPVGGSIQ------LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTE 3088
Query: 293 PQDQGTYSCVA 303
D G Y C+A
Sbjct: 3089 RDDAGRYQCLA 3099
Score = 50.1 bits (118), Expect = 4e-06
Identities = 58/230 (25%), Positives = 94/230 (40%), Gaps = 45/230 (19%)
Query: 93 DEGIFRCQAMNRNGKETKSNYRVRVYQIP------GKPEIVDSASELTAGVPNKVGTCVS 146
D G++ C+A N G K+ R+ VY P G+P +V + AG P + CV+
Sbjct: 376 DAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAV----AGRPVAL-ECVA 429
Query: 147 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 206
G +P+ TLSWH +G P V+ ++R + + L+S G +
Sbjct: 430 RG-HPSPTLSWHHEGLP-------VAESNESRLETDGSVLRLESP-------GEASSGLY 474
Query: 207 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP--GGTVTLTCEVPAQ 264
SC S P A+ ++ +V QL+V G V G + L C+
Sbjct: 475 SCVASS--PAGEAVLQYSVEVQV-------PPQLLVAEGLGQVTTIVGQPLELPCQASGS 525
Query: 265 PSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSS 307
P P I W+++G P L + + G ++C AT+ +
Sbjct: 526 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 575
Score = 48.9 bits (115), Expect = 8e-06
Identities = 64/241 (26%), Positives = 94/241 (39%), Gaps = 40/241 (16%)
Query: 78 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE--LTA 135
+LP GSL + V QD G + C A N G + + R ++ P I S S LTA
Sbjct: 2531 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG----RDLRVLEPPAIAPSPSNLTLTA 2586
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
P + C + GS P + W DG+ L R + L S ++
Sbjct: 2587 HTPALL-PCEASGS-PKPLVVWWKDGQKL------------DFRLQQGAYRLLPSNALLL 2632
Query: 196 PARGGDPRPTFSCSFSPGL-PRHRALR-TAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGG 253
A G F C S + HR + T + P + + ++ V +AP
Sbjct: 2633 TAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD----DQTDFTVT----MMAP-- 2682
Query: 254 TVTLTCEVPAQPSPQIHWMKDGVPL-------PLPPSPVLILPEIGPQDQGTYSCVATHS 306
V LTC P+P + W K G L + PS L + + P G Y+C A +S
Sbjct: 2683 -VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS 2741
Query: 307 S 307
+
Sbjct: 2742 A 2742
Score = 48.5 bits (114), Expect = 1e-05
Identities = 64/284 (22%), Positives = 103/284 (36%), Gaps = 53/284 (18%)
Query: 36 LKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEG 95
L+C A KPP + W+ + A L Q G SL + G
Sbjct: 1087 LECN-ATGKPPPTVTWERDGQPVGAELGLQLQNQGQ-----------SLHVERAQAAHTG 1134
Query: 96 IFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTL 155
+ C A N G+ + + + V P +D + +TA + + + P +
Sbjct: 1135 RYSCVAENLAGRAERK-FELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAI 1193
Query: 156 SWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 209
W +P+ P E G +K + ++GL++ + G+ R FS
Sbjct: 1194 RWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVE 1248
Query: 210 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 269
+ P E LEEV V++ G T L C V P P++
Sbjct: 1249 V--------------LVPPSIENEDLEEVIKVLD--------GQTAHLMCNVTGHPQPKL 1286
Query: 270 HWMKDGVPLP------LPPSPVLI-LPEIGPQDQGTYSCVATHS 306
W KDG PL + P VL+ + + G YSC+A ++
Sbjct: 1287 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA 1330
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/245 (25%), Positives = 98/245 (40%), Gaps = 35/245 (14%)
Query: 72 WDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSA- 130
W V + L + + D G +RC A N G T+ Y +RV +P + + S
Sbjct: 738 WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS-TELRYGLRV-NVPPRITLPPSLP 795
Query: 131 SELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP-NEKGVSVKEQTRRHPETGLFTLQ 189
+ P ++ TC + G+ P+ TL W DG P+ P G+ V P + TL
Sbjct: 796 GPVLVNTPVRL-TCNATGA-PSPTLMWLKDGNPVSPAGTPGLQV------FPGGRVLTLA 847
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
S AR D +SC + R + +Q + + EE+ + +V
Sbjct: 848 S------ARASDSG-RYSCVAVSAVGEDR--QDVVLQVHMPPSILGEELNV-------SV 891
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPP-------SPVLILPEIGPQDQGTYSCV 302
+V L C+ A P P + W KDG PL P +L + D G Y+C
Sbjct: 892 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCE 951
Query: 303 ATHSS 307
A + +
Sbjct: 952 ALNQA 956
Score = 47.4 bits (111), Expect = 2e-05
Identities = 70/291 (24%), Positives = 115/291 (39%), Gaps = 48/291 (16%)
Query: 67 QGGGPWDSVAR--VLPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGK 123
Q G P+ R VL +G + + + D + C A N+ G K + +RV Q+P +
Sbjct: 1690 QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKL-FTLRV-QVPPR 1747
Query: 124 PEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEK-----GVSVKEQTR 178
+D ++TA + + V ++P ++W+ D + L E+ G + R
Sbjct: 1748 IAGLD-LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGR 1806
Query: 179 -RHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEE 237
R ++G++T ++ A G D + P A R AP P+
Sbjct: 1807 ARLSDSGMYTCEA----LNAAGRDQKLVQLSVLVPP-----AFRQAPRGPQ--------- 1848
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPP-------SPVLILPE 290
+ V G L+CE A P P + W KDG PL L L + E
Sbjct: 1849 -------DAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 1901
Query: 291 IGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGP---TAGSVGGSGL 338
D+G YSC ++ + + +++ + P E P T V GS L
Sbjct: 1902 AQVSDKGLYSCKVSNVAGEAVRTFTLTVQ-VPPTFENPKTETVSQVAGSPL 1951
Score = 46.6 bits (109), Expect = 4e-05
Identities = 72/266 (27%), Positives = 97/266 (36%), Gaps = 29/266 (10%)
Query: 78 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGV 137
VL GSLFL +V D G + CQA N G T ++ VY P E D +G+
Sbjct: 53 VLEEGSLFLASVSPADSGDYECQATNEVGS-TSRRAKLVVYVPPSIRE--DGRKANVSGM 109
Query: 138 PNKVGT--CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM-- 193
+ T C + G +P + W D + LV G + + G L E
Sbjct: 110 AGQSLTLECDANG-FPVPEIVWLKDAQ-LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL 167
Query: 194 ----VTPARGGDPRPTFSCSFSPGLPRHRAL---RTAPIQPRVWEPVPLEEVQLVVEPEG 246
+ P R G S P L P P P + E
Sbjct: 168 HFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEV 227
Query: 247 GAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGP---------QDQG 297
+A G V L C P+PQ+ W KD P+ LP P L + E G D+G
Sbjct: 228 LGLA-GADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEG 285
Query: 298 TYSCVATHSSHGPQESRAVSISIIEP 323
Y CVA S Q++R + + P
Sbjct: 286 RYQCVA--FSPAGQQARDFQLRVHAP 309
Score = 45.4 bits (106), Expect = 9e-05
Identities = 48/195 (24%), Positives = 72/195 (36%), Gaps = 39/195 (20%)
Query: 151 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 210
P + W D +P++P + V+E + L +T + GD +F
Sbjct: 245 PTPQVEWTKDRQPVLPGGPHLQVQEDGQ------------VLRITGSHVGDEGRYQCVAF 292
Query: 211 SPGLPRHRALRT---APIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP 267
SP + R + AP P +W EV AV V L CE P+P
Sbjct: 293 SPAGQQARDFQLRVHAP--PTIWGSNETGEV---------AVMEDHLVQLLCEARGVPTP 341
Query: 268 QIHWMKDGVPLPLPPSPV-------LILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
I W KDG LP V L L D G Y+C A+++ +++ + + +
Sbjct: 342 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 401
Query: 321 IEPGEEGPTAGSVGG 335
PT GG
Sbjct: 402 ------PPTIEGAGG 410
Score = 43.9 bits (102), Expect = 3e-04
Identities = 74/330 (22%), Positives = 123/330 (37%), Gaps = 68/330 (20%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLP 80
VG + + ++ L L+C+ PP +K T + ++ +VL
Sbjct: 1453 VGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL-------------QVLG 1499
Query: 81 NGSLF-LPAVGIQDEGIFRCQAMNRNGKETKS-NYRVRVYQIPGKP-------EIVDSAS 131
G L + + D G + C A N G++ + N ++V + K EI+
Sbjct: 1500 EGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1559
Query: 132 ELTAGVP--------NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPET 183
E GV N + P L+W+ + +PL ++ VSV + R
Sbjct: 1560 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE-VSVLQGGR----- 1613
Query: 184 GLFTLQSELMVTPARGGDPRPTFSCSFSPGLPR----HRALRTAPIQPRVWEPVPLEEVQ 239
LQ L+ G +SC S + + L P PV L + +
Sbjct: 1614 ---VLQIPLVRAENAG-----RYSCKASNEVGEDWLHYELLVLTP-------PVILGDTE 1658
Query: 240 LVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGP------ 293
+VE V TV+L C P P I W+++G LP PSP L + E G
Sbjct: 1659 ELVEEV--TVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVST 1714
Query: 294 ---QDQGTYSCVATHSSHGPQESRAVSISI 320
D +Y CVA + + ++ + + +
Sbjct: 1715 AEVADAASYMCVAENQAGSAEKLFTLRVQV 1744
Score = 43.5 bits (101), Expect = 3e-04
Identities = 83/339 (24%), Positives = 136/339 (40%), Gaps = 49/339 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ A G P+ L+C A P L W E V + +R+ +GS+
Sbjct: 415 VKAVAGRPVALECV-ARGHPSPTLSW-----HHEGLPVAE-------SNESRLETDGSVL 461
Query: 86 -LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA--GVPNKVG 142
L + G G++ C A + G E Y V V Q+P + + + ++T G P ++
Sbjct: 462 RLESPGEASSGLYSCVASSPAG-EAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLEL- 518
Query: 143 TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQ-TRRHPE------TGLFTLQSELMVT 195
C + GS P T+ W +G+P GV V Q T H + +GLF Q+
Sbjct: 519 PCQASGS-PVPTIQWLQNGRP-AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 576
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEP---EGGAVAPG 252
A G + + ++PG+ PI W +P G P
Sbjct: 577 TA-GAEVEVSVHGEWAPGVLE------VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPK 629
Query: 253 GTVTLTCEVPAQPSPQIHWMKD-GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQ 311
+ V SP W + G+P+ P L + ++ +D+G Y+C AT+ + +
Sbjct: 630 PPL-----VEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLA--GE 682
Query: 312 ESRAVSISIIEPG--EEGPTAGSVGGSGLGTL-ALALGI 347
R V++ ++ P E GP +V + TL LA G+
Sbjct: 683 SKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGV 721
Score = 37.7 bits (86), Expect = 0.019
Identities = 67/315 (21%), Positives = 104/315 (33%), Gaps = 80/315 (25%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVA--RVL 79
G +T +G+PL L C+ A P ++W Q G P + +A +V
Sbjct: 504 GLGQVTTIVGQPLELPCQ-ASGSPVPTIQWL--------------QNGRPAEELAGVQVA 548
Query: 80 PNGS-LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 138
G+ L + V + G+F CQA N G + +E+ V
Sbjct: 549 SQGTTLHIDHVELDHSGLFACQATNEAG---------------------TAGAEVEVSVH 587
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLF-------TLQSE 191
+ V E P G W + P V HP+ L +L E
Sbjct: 588 GEWAPGVLE--VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE 645
Query: 192 LMVTPARGGDPRP------------TFSCSFS--PGLPRHRALRTAPIQPRVWEPVPLEE 237
P P P ++C+ + G + + P + EP P+ +
Sbjct: 646 PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNI-EPGPVNK 704
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPE 290
AV +VTL C P P + W K P+ VL + +
Sbjct: 705 ----------AVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 754
Query: 291 IGPQDQGTYSCVATH 305
D G+Y CVA++
Sbjct: 755 AQLSDAGSYRCVASN 769
Score = 35.0 bits (79), Expect = 0.12
Identities = 47/204 (23%), Positives = 74/204 (36%), Gaps = 30/204 (14%)
Query: 152 AGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM----VTPARGGDPRPTFS 207
AG H KP V KG S + H + G+ L+ + V+PA GD +
Sbjct: 21 AGGCGTHGTPKPQVTWRKGPSSEPL---HGQPGVAVLEEGSLFLASVSPADSGD----YE 73
Query: 208 CSFSP--GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
C + G RA + P + E V + G ++TL C+ P
Sbjct: 74 CQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMA---------GQSLTLECDANGFP 124
Query: 266 SPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGE 325
P+I W+KD + +P ++G G + + E +++ I+PG
Sbjct: 125 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLL--------DEGQSLHFPRIQPGR 176
Query: 326 EGPTAGSVGGSGLGTLALALGILG 349
G GGS G+ G
Sbjct: 177 SGRRGAQAGGSAQTKAPWXAGLAG 200
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 77.8 bits (190), Expect = 2e-14
Identities = 86/304 (28%), Positives = 124/304 (40%), Gaps = 53/304 (17%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVG 90
G+ + L C+ A +PP + W L G SP G + L GSL L +
Sbjct: 3232 GQEVRLDCE-ADGQPPPDVAW-LKDG--------SPLGQDMGPHLRFYLDGGSLVLKGLR 3281
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT--CVSEG 148
D G + C A N G++ + + V V P + D + L + P ++ T C G
Sbjct: 3282 ASDAGAYTCVAHNPAGEDARL-HTVNVLVPPTIKQGADGSGTLVSR-PGELVTMVCPVRG 3339
Query: 149 SYPAGTLSWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 202
S P +SW DG PL +++ G +++ + + G+FT + +PA D
Sbjct: 3340 SPPIH-VSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC---VAASPAGVADR 3395
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
T P V EPV + +VV G V L CE
Sbjct: 3396 NFTLQVQVPP----------------VLEPVEFQNDVVVVR--------GSLVELPCEAR 3431
Query: 263 AQPSPQIHWMKDGVPL---PLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSIS 319
P P + WMKDG PL L P L L +G D GTYSCVA S + R ++
Sbjct: 3432 GVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAV--SEAGEARRHFQLT 3489
Query: 320 IIEP 323
++EP
Sbjct: 3490 VMEP 3493
Score = 73.9 bits (180), Expect = 2e-13
Identities = 92/328 (28%), Positives = 127/328 (38%), Gaps = 62/328 (18%)
Query: 25 NITARIGEPLVLKCK--GAPK------KPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVA 76
N+T P +L C+ G+PK K Q+L+++L G
Sbjct: 3772 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG------------------AY 3813
Query: 77 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAG 136
R+LP+ +L L A G QD F C N G E Y+V V+ +P P I D ++ T
Sbjct: 3814 RLLPSNALLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVH-VP--PTIADDQTDFTVT 3869
Query: 137 VPNKVG-TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
+ V TC S G PA T+SW G L G V +G + L
Sbjct: 3870 MMAPVVLTCHSTG-IPAPTVSWSKAGAQLGARGSGYRVS-------PSGALEIGQAL--- 3918
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTV 255
P G R T S S G+ T P V +P+P V+ V E E V
Sbjct: 3919 PIHAG--RYTCSARNSAGVAHKHVFLTVQASP-VVKPLP-SVVRAVAEEE---------V 3965
Query: 256 TLTCEVPAQPSPQIHWMKD------GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHG 309
L CE P P I W K+ GV + P L + P+D G Y C+A +S+
Sbjct: 3966 LLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025
Query: 310 PQESRAVSISIIEPGEEG-PTAGSVGGS 336
+ + + E G P + GS
Sbjct: 4026 AMGKTRLVVQVPPVIENGLPDLSTTEGS 4053
Score = 70.9 bits (172), Expect = 2e-12
Identities = 89/346 (25%), Positives = 138/346 (39%), Gaps = 53/346 (15%)
Query: 11 VLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGG 70
+LVL ++ + G +++ R+G+ L L+C A P R+ W +N + +S Q GG
Sbjct: 4125 ILVLPVFTTLPGDRSL--RLGDRLWLRC-AARGSPTPRIGWTVND--RPVTEGVSEQDGG 4179
Query: 71 PWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSA 130
+L AV +D G + C A NR G+ ++ V V + P ++
Sbjct: 4180 -----------STLQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG--EAF 4225
Query: 131 SELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ 189
S L V + CV G P + W DG PL +G ++ Q LQ
Sbjct: 4226 SYLVEPVGGSIQLDCVVRGD-PVPDIHWIKDGLPL----RGSHLRHQ-----------LQ 4269
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
+ + D + C L + + V + P+ +V EP+ V
Sbjct: 4270 NGSLTIHRTERDDAGRYQC-----LAENEMGVAKKVVILVLQSAPVFQV----EPQDMTV 4320
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLP------PSPVLILPEIGPQDQGTYSCVA 303
G V L C+ +P+P I W++ G PL P L L + D GTY CVA
Sbjct: 4321 RSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 4380
Query: 304 THSSHGPQESRAVSISIIEP-GEEGPTAGSVGGSGLGTLALALGIL 348
H+ G +RA + EP G G G + G G L ++
Sbjct: 4381 -HNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVM 4425
Score = 66.6 bits (161), Expect = 4e-11
Identities = 81/293 (27%), Positives = 121/293 (41%), Gaps = 50/293 (17%)
Query: 20 VVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVL 79
+V A N+T GE VL C+ + P L W W+VL S RV
Sbjct: 520 LVPAPNVTVSPGETAVLSCR-VLGEAPYNLTW------VRDWRVLPA-------STGRVA 565
Query: 80 PNGSLFLPAVGI--QDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGV 137
L L GI D G ++C A N NG T+++ + V + P + I S+ + GV
Sbjct: 566 QLADLSLEISGIIPTDGGRYQCVASNANG-VTRASVWLLVREAP-QVSIHTSSQHFSQGV 623
Query: 138 PNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPET-GLFTLQSELMVTP 196
KV +C + G YP +SW + + L +E +R H + G +Q V P
Sbjct: 624 EVKV-SCSASG-YPTPHISWSRESQAL---------QEDSRIHVDAQGTLIIQG---VAP 669
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
G+ +SC + + + T +P + V VV VA G
Sbjct: 670 EDAGN----YSCQATNEVGTDQETVTL----YYTDPPSVSAVNAVV-----LVAVGEEAV 716
Query: 257 LTCEVPAQPSPQIHWMKDGVPLPLPP----SPVLILPEIGPQDQGTYSCVATH 305
L CE P P++ W + G+ + L P S L +P +D GTY+C A +
Sbjct: 717 LVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 769
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/320 (24%), Positives = 130/320 (40%), Gaps = 59/320 (18%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ +GE VL C+ A PP R+ W R +L+P+G +G L
Sbjct: 707 VLVAVGEEAVLVCE-ASGVPPPRVIWY----RGGLEMILAPEGSS----------SGKLR 751
Query: 86 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
+PA +D G + C+A+N G + + ++ V P ++ + ++T +
Sbjct: 752 IPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAP---QLTELPRDVTVELGRSALLAC 807
Query: 146 SEGSYPAGTLSWHL-DGKPLVPNEKGVSV---KEQTRRHPETGLFTLQSELMVTPARGGD 201
P T++W DG+PL G+ + + R P++G+ +S V P +
Sbjct: 808 RATGRPPPTVTWRRGDGQPL-----GLRLGAGRGSRSRQPDSGVLFFES---VAP----E 855
Query: 202 PRPTFSCS----FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTL 257
+ + C F R + T P++ P V G V+L
Sbjct: 856 DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV-----------LEGQPVSL 904
Query: 258 TCEVPA-QPSPQIHWMKDGVPLP------LPPSPVLILPEIGPQDQGTYSCVATHSSHGP 310
C V A +P P+ HW+KDG PLP + L L + G YSCVAT+++
Sbjct: 905 PCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTA--G 962
Query: 311 QESRAVSISIIEPGEEGPTA 330
+ R V + + P PTA
Sbjct: 963 SQHRDVELVVQVPPRIHPTA 982
Score = 62.0 bits (149), Expect = 9e-10
Identities = 80/327 (24%), Positives = 125/327 (38%), Gaps = 86/327 (26%)
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS----ELTAGVP 138
SL L AVG D G + C A++ G E + ++++ V + P I DS LT G P
Sbjct: 3457 SLQLEAVGAGDSGTYSCVAVSEAG-EARRHFQLTVME---PPHIEDSGQPTELSLTPGAP 3512
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE------- 191
++ C ++G+ P ++WH DG+ L E S + R + GL+T +E
Sbjct: 3513 MEL-LCDAQGT-PQPNITWHKDGQALTRLENN-SRATRVLRVRDAGLYTCLAESPAGAIE 3569
Query: 192 ------LMVTPARGGDPRPTFSCSFSPG-LPRHRALRTAPIQPRVW--EPVPLEEVQLVV 242
+ P G P F +PG L ++ P W + + L+E
Sbjct: 3570 KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQ 3629
Query: 243 EPEGGA------------------------------------------------VAPGGT 254
PE G V+ T
Sbjct: 3630 FPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQT 3689
Query: 255 VTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVL-ILPE-------IGPQDQGTYSCVATHS 306
L C+ P+P + W KD VPL P SP ILPE + QD G Y C+A++S
Sbjct: 3690 ALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 3748
Query: 307 SHGPQESRAVSISIIEPGEEGPTAGSV 333
+ ++ R + ++EP P+ ++
Sbjct: 3749 AGSDRQGR--DLRVLEPPAIAPSPSNL 3773
Score = 58.9 bits (141), Expect = 8e-09
Identities = 73/312 (23%), Positives = 123/312 (39%), Gaps = 50/312 (16%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPN 81
G+ + +R GE + + C PP + W + G P R L +
Sbjct: 3319 GSGTLVSRPGELVTMVCP-VRGSPPIHVSWL--------------KDGLPLPLSQRTLLH 3363
Query: 82 GS---LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 138
GS L + V + D GIF C A + G + N+ ++V Q+P E V+ +++
Sbjct: 3364 GSGHTLRISKVQLADAGIFTCVAASPAGVADR-NFTLQV-QVPPVLEPVEFQNDVVVVRG 3421
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPN--EKGVSVKEQTRRHPETGLFTLQSELMVTP 196
+ V P +SW DG+PL+ E+G S++ + ++G ++ V
Sbjct: 3422 SLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC-----VAV 3476
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
+ G+ R F Q V EP +E+ +P ++ PG +
Sbjct: 3477 SEAGEARRHF-------------------QLTVMEPPHIEDSG---QPTELSLTPGAPME 3514
Query: 257 LTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAV 316
L C+ P P I W KDG L + + +D G Y+C+A + ++S V
Sbjct: 3515 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 3574
Query: 317 SISIIEPGEEGP 328
+ P GP
Sbjct: 3575 RVQ-APPNIVGP 3585
Score = 58.2 bits (139), Expect = 1e-08
Identities = 83/336 (24%), Positives = 132/336 (39%), Gaps = 60/336 (17%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ R+G+ VL C+ P +K A + + +GG L
Sbjct: 3042 VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ------------RLE 3089
Query: 86 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK--VGT 143
+ + D+G++ C+ N G+ ++ + + V Q+P P + +E + V V T
Sbjct: 3090 IQEAQVSDKGLYSCKVSNVAGEAVRT-FTLTV-QVP--PTFENPKTETVSQVAGSPLVLT 3145
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPR 203
C G PA T++W D P+ + +V R L LQ PA+ G
Sbjct: 3146 CDVSG-VPAPTVTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQ------PAQAG--- 3191
Query: 204 PTFSC--SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
T++C + R + + PR+ E V G V L CE
Sbjct: 3192 -TYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH---------VLEGQEVRLDCEA 3241
Query: 262 PAQPSPQIHWMKDGVPLPLPPSP---------VLILPEIGPQDQGTYSCVATHSSHGPQE 312
QP P + W+KDG PL P L+L + D G Y+CVA H+ G ++
Sbjct: 3242 DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA-HNPAG-ED 3299
Query: 313 SRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGIL 348
+R +++++ P PT G G GTL G L
Sbjct: 3300 ARLHTVNVLVP----PTI-KQGADGSGTLVSRPGEL 3330
Score = 57.0 bits (136), Expect = 3e-08
Identities = 76/319 (23%), Positives = 117/319 (36%), Gaps = 43/319 (13%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSL 84
NITA + PL L C+ A PP + W + P + + L
Sbjct: 2361 NITAALHSPLTLLCE-AMGIPPPAIRW-----------FRGEEPVSPGEDTYLLAGGWML 2408
Query: 85 FLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGT 143
+ QD G++ C A N G E + N+ V V P + E ++ ++ G +
Sbjct: 2409 KMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 2467
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKG-VSVKEQTRRHPETGLFTLQSELMVTPARGGDP 202
V+ +P L+W DG+PL + +S + + L + + G+
Sbjct: 2468 NVT--GHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 2525
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
F S + AP E EEV + V ++L CE
Sbjct: 2526 TKHFQLS----------VLLAPTILGGAEDSADEEVTVTVN---------NPISLICEAL 2566
Query: 263 AQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRA 315
A PSP I WMKDG P LP + L + +D G Y+CV T+ ++
Sbjct: 2567 AFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYH 2626
Query: 316 VSISIIEPGEEGPTAGSVG 334
V + I + G VG
Sbjct: 2627 VEVLIPPSISKDDPLGEVG 2645
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/247 (22%), Positives = 103/247 (41%), Gaps = 33/247 (13%)
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE-LTAGVPNKV 141
+L L + D G++ C+A+N G++ K ++ V P + + + V +K
Sbjct: 2992 TLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 3050
Query: 142 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
+ P T++W+ DG+PLV ++ +++ R L + A+ D
Sbjct: 3051 VLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR-------------LEIQEAQVSD 3097
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQ-PRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCE 260
+ +SC S T +Q P +E E V V G + LTC+
Sbjct: 3098 -KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA---------GSPLVLTCD 3147
Query: 261 VPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
V P+P + W+KD +P+ + L L + P GTY+CVA ++ ++
Sbjct: 3148 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKD 3207
Query: 314 RAVSISI 320
V++ +
Sbjct: 3208 FVVAVLV 3214
Score = 56.2 bits (134), Expect = 5e-08
Identities = 82/339 (24%), Positives = 125/339 (36%), Gaps = 74/339 (21%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQG--GGPWD------SVA 76
N++ G+ L L+C A P + W +A V P G G WD
Sbjct: 1309 NVSGMAGQSLTLECD-ANGFPVPEIVWL-----KDAQLVGVPLGWAGYGWDLGWGQVGGH 1362
Query: 77 RVLPNG-SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA 135
R+L G SL P + D G++ C+A N+ G + + + ++ S L A
Sbjct: 1363 RLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLL----------VLTPPSVLGA 1412
Query: 136 GVPNKVG---------TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLF 186
G +V C + G P + W D +P++P + V+E +
Sbjct: 1413 GAAQEVLGLAGADVELQCWTSG-VPTPQVEWTKDRQPVLPGGPHLQVQEDGQ-------- 1463
Query: 187 TLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRT---APIQPRVWEPVPLEEVQLVVE 243
L +T + GD +FSP + R + AP P +W EV
Sbjct: 1464 ----VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP--PTIWGSNETGEV----- 1512
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPV-------LILPEIGPQDQ 296
AV V L CE P+P I W KDG LP V L L D
Sbjct: 1513 ----AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDA 1568
Query: 297 GTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGG 335
G Y+C A+++ +++ + + + PT GG
Sbjct: 1569 GVYTCKASNAVGAAEKATRLDVYV------PPTIEGAGG 1601
Score = 55.8 bits (133), Expect = 7e-08
Identities = 82/285 (28%), Positives = 109/285 (38%), Gaps = 53/285 (18%)
Query: 32 EPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWD-SVARVLPNGSLFLPAVG 90
+P V + GA KPP E W G P VA LP L + V
Sbjct: 1808 DPPVHRGWGAHPKPPL----------VEGWCSPGSLWGEPTGIPVAYSLPP-PLQIEKVD 1856
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGTCVSEGS 149
++DEGI+ C A N G E+K ++V P +P V+ A A V + C++ G
Sbjct: 1857 LRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLE---CLASG- 1911
Query: 150 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 209
P +SW +P V + GV+V R L + A+ D ++ C
Sbjct: 1912 VPPPDVSWFKGHQP-VSSWMGVTVSVDGR------------VLRIEQAQLSDAG-SYRCV 1957
Query: 210 FS--PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP 267
S G R + PR+ P L LV P V LTC PSP
Sbjct: 1958 ASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP----------VRLTCNATGAPSP 2007
Query: 268 QIHWMKDGVPLP---------LPPSPVLILPEIGPQDQGTYSCVA 303
+ W+KDG P+ P VL L D G YSCVA
Sbjct: 2008 TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVA 2052
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/323 (22%), Positives = 120/323 (37%), Gaps = 43/323 (13%)
Query: 11 VLVLSLWGAVVGAQ-NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGG 69
VL + + +++G + N++ E + L+C+ PP WK GR L P+ G
Sbjct: 2064 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK--DGRP-----LEPRPG 2116
Query: 70 GPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS 129
V L + + D G + C+A+N+ G K +Y + V+ P P
Sbjct: 2117 -----VHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEK-HYNLNVWVAPVFPLRESH 2170
Query: 130 ASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ 189
+ G P + +C G P +SW DG+PL G+ R L+ Q
Sbjct: 2171 TLTVREGHPTSL-SCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRL----LYLGQ 2224
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
++L + T CS G + P++ P P +V
Sbjct: 2225 AQL------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE--------PPTQVSV 2270
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLP-------PSPVLILPEIGPQDQGTYSCV 302
G TL C +P P + W +DG P+ L + G YSCV
Sbjct: 2271 VQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCV 2330
Query: 303 ATHSSHGPQESRAVSISIIEPGE 325
A + + + R +S++ P E
Sbjct: 2331 AENLA--GRAERKFELSVLVPPE 2351
Score = 54.3 bits (129), Expect = 2e-07
Identities = 66/305 (21%), Positives = 114/305 (37%), Gaps = 42/305 (13%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 83
+++T +G +L C+ +PP + W+ G+ ++ + +G S +R +G
Sbjct: 793 RDVTVELGRSALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRG-----SRSRQPDSGV 846
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS--ELTAGVPNKV 141
LF +V +D+ + C+A N GK + P P+I SA + G P +
Sbjct: 847 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--PQIASSAPTVRVLEGQPVSL 904
Query: 142 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C+ P W DG+PL P + S++ H + L +
Sbjct: 905 -PCIVLAGRPLPERHWLKDGRPLPPGSRH-SIRADGSLHLDRAL--------------QE 948
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+SC A TA Q R E V ++ G +L C
Sbjct: 949 HAGRYSCV---------ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVA 999
Query: 262 PAQPSPQIHWMKD-------GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESR 314
P+P I W K+ G + L++ + QD G Y C AT++ +
Sbjct: 1000 SGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEM 1059
Query: 315 AVSIS 319
+S++
Sbjct: 1060 RLSVN 1064
Score = 51.2 bits (121), Expect = 2e-06
Identities = 77/286 (26%), Positives = 106/286 (37%), Gaps = 55/286 (19%)
Query: 77 RVLPNGS-LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA 135
+V P G L L + D G + C A++ G++ + V Q+ P I+ ++
Sbjct: 2027 QVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV----VLQVHMPPSILGEELNVSV 2082
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
V + P LSW DG+PL P P L ++ L V
Sbjct: 2083 VANESVALECQSHAMPPPVLSWWKDGRPLEPR-------------PGVHLSADKALLQVD 2129
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPR-----VW-EPV-PLEEVQLVVEPEGGA 248
A D ++C AL A + VW PV PL E +
Sbjct: 2130 RADVWDAGH-YTCE---------ALNQAGHSEKHYNLNVWVAPVFPLRESHTLT------ 2173
Query: 249 VAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP---------LPPSPVLILPEIGPQDQGTY 299
V G +L+CE P P+I W KDG PLP +L L + +GTY
Sbjct: 2174 VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTY 2233
Query: 300 SC----VATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTL 341
+C V +SS Q V I P E PT SV G+ TL
Sbjct: 2234 TCECSNVVGNSSQDLQLEVHVPPQIAGP-REPPTQVSVVQDGVATL 2278
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/311 (24%), Positives = 125/311 (40%), Gaps = 51/311 (16%)
Query: 2 AAGTAVGAWVLVLSLWGAVV-GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
+AG+A+G LV+ + + G +++ G L CK A P + W
Sbjct: 4022 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK-ARGSPEPNITWD-------- 4072
Query: 61 WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 120
K P G + + P+G L + + QD G + C A N G+ + RV + I
Sbjct: 4073 -KDGQPVSGA--EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR---RVHL-TI 4125
Query: 121 PGKPEIVDSASELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRR 179
P + + + +++ C + GS P + W ++ +P+ +GVS ++
Sbjct: 4126 LVLPVFTTLPGDRSLRLGDRLWLRCAARGS-PTPRIGWTVNDRPVT---EGVSEQD---- 4177
Query: 180 HPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEV- 238
G TLQ + G T+ C + R +A+ ++ PV E
Sbjct: 4178 ----GGSTLQRAAVSREDSG-----TYVCWAENRVGRTQAVSFVHVKEA---PVLQGEAF 4225
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPL------PLPPSPVLILPEIG 292
+VEP GG++ L C V P P IHW+KDG+PL + L +
Sbjct: 4226 SYLVEPVGGSIQ------LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTE 4279
Query: 293 PQDQGTYSCVA 303
D G Y C+A
Sbjct: 4280 RDDAGRYQCLA 4290
Score = 50.1 bits (118), Expect = 4e-06
Identities = 58/230 (25%), Positives = 94/230 (40%), Gaps = 45/230 (19%)
Query: 93 DEGIFRCQAMNRNGKETKSNYRVRVYQIP------GKPEIVDSASELTAGVPNKVGTCVS 146
D G++ C+A N G K+ R+ VY P G+P +V + AG P + CV+
Sbjct: 1567 DAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAV----AGRPVAL-ECVA 1620
Query: 147 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 206
G +P+ TLSWH +G P V+ ++R + + L+S G +
Sbjct: 1621 RG-HPSPTLSWHHEGLP-------VAESNESRLETDGSVLRLESP-------GEASSGLY 1665
Query: 207 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP--GGTVTLTCEVPAQ 264
SC S P A+ ++ +V QL+V G V G + L C+
Sbjct: 1666 SCVASS--PAGEAVLQYSVEVQV-------PPQLLVAEGLGQVTTIVGQPLELPCQASGS 1716
Query: 265 PSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSS 307
P P I W+++G P L + + G ++C AT+ +
Sbjct: 1717 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 1766
Score = 49.7 bits (117), Expect = 5e-06
Identities = 87/336 (25%), Positives = 127/336 (37%), Gaps = 79/336 (23%)
Query: 3 AGTAVGAWVLVLSLWGAVV-GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAW 61
AG+A +VL + + V G + + +GE L L C PQ L W ++
Sbjct: 1105 AGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ-LSW------SKDG 1157
Query: 62 KVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIP 121
VL +G P GS+ A+ D G +RC+A N G + +RV + P
Sbjct: 1158 VVLQGRG-----------PQGSVHFAAIRTSDAGRYRCEASNSAGVDA-WEVELRVLEPP 1205
Query: 122 --GKPE---IVDSASELTAGVPNKV-GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKE 175
G E +++ + A +P GT + ++ G S L G+P GV+V E
Sbjct: 1206 HWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQP------GVAVLE 1259
Query: 176 QTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFS--PGLPRHRALRTAPIQPRVWEPV 233
E LF V+PA GD + C + G RA + P + E
Sbjct: 1260 ------EGSLFLAS----VSPADSGD----YECQATNEVGSTSRRAKLVVYVPPSIREDG 1305
Query: 234 PLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKD----GVPLP---------- 279
V + G ++TL C+ P P+I W+KD GVPL
Sbjct: 1306 RKANVSGMA---------GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 1356
Query: 280 --------LPPSPVLILPEIGPQDQGTYSCVATHSS 307
L L P I D G YSC A + +
Sbjct: 1357 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA 1392
Score = 48.9 bits (115), Expect = 8e-06
Identities = 64/241 (26%), Positives = 94/241 (39%), Gaps = 40/241 (16%)
Query: 78 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE--LTA 135
+LP GSL + V QD G + C A N G + + R ++ P I S S LTA
Sbjct: 3722 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG----RDLRVLEPPAIAPSPSNLTLTA 3777
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
P + C + GS P + W DG+ L R + L S ++
Sbjct: 3778 HTPALL-PCEASGS-PKPLVVWWKDGQKL------------DFRLQQGAYRLLPSNALLL 3823
Query: 196 PARGGDPRPTFSCSFSPGL-PRHRALR-TAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGG 253
A G F C S + HR + T + P + + ++ V +AP
Sbjct: 3824 TAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD----DQTDFTVT----MMAP-- 3873
Query: 254 TVTLTCEVPAQPSPQIHWMKDGVPL-------PLPPSPVLILPEIGPQDQGTYSCVATHS 306
V LTC P+P + W K G L + PS L + + P G Y+C A +S
Sbjct: 3874 -VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS 3932
Query: 307 S 307
+
Sbjct: 3933 A 3933
Score = 48.5 bits (114), Expect = 1e-05
Identities = 64/284 (22%), Positives = 103/284 (36%), Gaps = 53/284 (18%)
Query: 36 LKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEG 95
L+C A KPP + W+ + A L Q G SL + G
Sbjct: 2278 LECN-ATGKPPPTVTWERDGQPVGAELGLQLQNQGQ-----------SLHVERAQAAHTG 2325
Query: 96 IFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTL 155
+ C A N G+ + + + V P +D + +TA + + + P +
Sbjct: 2326 RYSCVAENLAGRAERK-FELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAI 2384
Query: 156 SWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 209
W +P+ P E G +K + ++GL++ + G+ R FS
Sbjct: 2385 RWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVE 2439
Query: 210 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 269
+ P E LEEV V++ G T L C V P P++
Sbjct: 2440 V--------------LVPPSIENEDLEEVIKVLD--------GQTAHLMCNVTGHPQPKL 2477
Query: 270 HWMKDGVPLP------LPPSPVLI-LPEIGPQDQGTYSCVATHS 306
W KDG PL + P VL+ + + G YSC+A ++
Sbjct: 2478 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA 2521
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/245 (25%), Positives = 98/245 (40%), Gaps = 35/245 (14%)
Query: 72 WDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSA- 130
W V + L + + D G +RC A N G T+ Y +RV +P + + S
Sbjct: 1929 WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS-TELRYGLRV-NVPPRITLPPSLP 1986
Query: 131 SELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP-NEKGVSVKEQTRRHPETGLFTLQ 189
+ P ++ TC + G+ P+ TL W DG P+ P G+ V P + TL
Sbjct: 1987 GPVLVNTPVRL-TCNATGA-PSPTLMWLKDGNPVSPAGTPGLQV------FPGGRVLTLA 2038
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
S AR D +SC + R + +Q + + EE+ + +V
Sbjct: 2039 S------ARASDSG-RYSCVAVSAVGEDR--QDVVLQVHMPPSILGEELNV-------SV 2082
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPP-------SPVLILPEIGPQDQGTYSCV 302
+V L C+ A P P + W KDG PL P +L + D G Y+C
Sbjct: 2083 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCE 2142
Query: 303 ATHSS 307
A + +
Sbjct: 2143 ALNQA 2147
Score = 47.4 bits (111), Expect = 2e-05
Identities = 70/291 (24%), Positives = 115/291 (39%), Gaps = 48/291 (16%)
Query: 67 QGGGPWDSVAR--VLPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGK 123
Q G P+ R VL +G + + + D + C A N+ G K + +RV Q+P +
Sbjct: 2881 QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKL-FTLRV-QVPPR 2938
Query: 124 PEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEK-----GVSVKEQTR 178
+D ++TA + + V ++P ++W+ D + L E+ G + R
Sbjct: 2939 IAGLD-LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGR 2997
Query: 179 -RHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEE 237
R ++G++T ++ A G D + P A R AP P+
Sbjct: 2998 ARLSDSGMYTCEA----LNAAGRDQKLVQLSVLVPP-----AFRQAPRGPQ--------- 3039
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPP-------SPVLILPE 290
+ V G L+CE A P P + W KDG PL L L + E
Sbjct: 3040 -------DAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 3092
Query: 291 IGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGP---TAGSVGGSGL 338
D+G YSC ++ + + +++ + P E P T V GS L
Sbjct: 3093 AQVSDKGLYSCKVSNVAGEAVRTFTLTVQ-VPPTFENPKTETVSQVAGSPL 3142
Score = 43.9 bits (102), Expect = 3e-04
Identities = 63/298 (21%), Positives = 106/298 (35%), Gaps = 48/298 (16%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNG 82
A I + +PL++ C P RL+ + R + G W+ +
Sbjct: 433 APRIHGYLHQPLLVSCS-VHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR------ 485
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
+EG + C A++R G + ++ P++V + + + V
Sbjct: 486 ------ASKAEEGTYECTAVSRAGT---GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVL 536
Query: 143 TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM-VTPARGGD 201
+C G P L+W D + L + V+ L L E+ + P GG
Sbjct: 537 SCRVLGEAPYN-LTWVRDWRVLPASTGRVAQ-----------LADLSLEISGIIPTDGG- 583
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+ C S RA VW V E Q+ + + G V ++C
Sbjct: 584 ---RYQCVASNANGVTRA--------SVWLLVR-EAPQVSIHTSSQHFSQGVEVKVSCSA 631
Query: 262 PAQPSPQIHWMKDGVPLP------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
P+P I W ++ L + LI+ + P+D G YSC AT+ QE+
Sbjct: 632 SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET 689
Score = 43.9 bits (102), Expect = 3e-04
Identities = 74/330 (22%), Positives = 123/330 (37%), Gaps = 68/330 (20%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLP 80
VG + + ++ L L+C+ PP +K T + ++ +VL
Sbjct: 2644 VGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL-------------QVLG 2690
Query: 81 NGSLF-LPAVGIQDEGIFRCQAMNRNGKETKS-NYRVRVYQIPGKP-------EIVDSAS 131
G L + + D G + C A N G++ + N ++V + K EI+
Sbjct: 2691 EGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 2750
Query: 132 ELTAGVP--------NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPET 183
E GV N + P L+W+ + +PL ++ VSV + R
Sbjct: 2751 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE-VSVLQGGR----- 2804
Query: 184 GLFTLQSELMVTPARGGDPRPTFSCSFSPGLPR----HRALRTAPIQPRVWEPVPLEEVQ 239
LQ L+ G +SC S + + L P PV L + +
Sbjct: 2805 ---VLQIPLVRAENAG-----RYSCKASNEVGEDWLHYELLVLTP-------PVILGDTE 2849
Query: 240 LVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGP------ 293
+VE V TV+L C P P I W+++G LP PSP L + E G
Sbjct: 2850 ELVEEV--TVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVST 2905
Query: 294 ---QDQGTYSCVATHSSHGPQESRAVSISI 320
D +Y CVA + + ++ + + +
Sbjct: 2906 AEVADAASYMCVAENQAGSAEKLFTLRVQV 2935
Score = 43.5 bits (101), Expect = 3e-04
Identities = 83/339 (24%), Positives = 136/339 (40%), Gaps = 49/339 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ A G P+ L+C A P L W E V + +R+ +GS+
Sbjct: 1606 VKAVAGRPVALECV-ARGHPSPTLSW-----HHEGLPVAE-------SNESRLETDGSVL 1652
Query: 86 -LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA--GVPNKVG 142
L + G G++ C A + G E Y V V Q+P + + + ++T G P ++
Sbjct: 1653 RLESPGEASSGLYSCVASSPAG-EAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLEL- 1709
Query: 143 TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQ-TRRHPE------TGLFTLQSELMVT 195
C + GS P T+ W +G+P GV V Q T H + +GLF Q+
Sbjct: 1710 PCQASGS-PVPTIQWLQNGRP-AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 1767
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEP---EGGAVAPG 252
A G + + ++PG+ PI W +P G P
Sbjct: 1768 TA-GAEVEVSVHGEWAPGVLE------VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPK 1820
Query: 253 GTVTLTCEVPAQPSPQIHWMKD-GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQ 311
+ V SP W + G+P+ P L + ++ +D+G Y+C AT+ + +
Sbjct: 1821 PPL-----VEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLA--GE 1873
Query: 312 ESRAVSISIIEPG--EEGPTAGSVGGSGLGTL-ALALGI 347
R V++ ++ P E GP +V + TL LA G+
Sbjct: 1874 SKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGV 1912
Score = 43.1 bits (100), Expect = 4e-04
Identities = 75/304 (24%), Positives = 105/304 (34%), Gaps = 43/304 (14%)
Query: 70 GPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS 129
GP +V++ G+L + QD G + C A N G ++ R+ V ++ + +
Sbjct: 1020 GPHYNVSK---EGTLLIAQPSAQDAGAYVCTATNTVGFSSQ-EMRLSVNRLALSKYVWEE 1075
Query: 130 ASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ 189
L +G V + + T S + G GV V Q + P +
Sbjct: 1076 YGLLPSGSLRLAQVQVGDSGHYECTAS-NPAGSASHRYVLGVQVPPQVQPGPRVLKVLVG 1134
Query: 190 SELMVTPARGGDPRPTFSCSFS---------PGLPRHRALRTAPIQPRVWEP-----VPL 235
L + G+P P S S G A+RT+ E V
Sbjct: 1135 EALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDA 1194
Query: 236 EEVQLVV--EPEGGAVAPGG--------TVTLTCEVPAQPSPQIHWMKDGVPLPLPPSP- 284
EV+L V P GA G +L C P PQ+ W K PL P
Sbjct: 1195 WEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPG 1254
Query: 285 -------VLILPEIGPQDQGTYSCVATHSSHGPQESRA-----VSISIIEPGEEGPTAGS 332
L L + P D G Y C AT+ G RA V SI E G + +G
Sbjct: 1255 VAVLEEGSLFLASVSPADSGDYECQATNEV-GSTSRRAKLVVYVPPSIREDGRKANVSGM 1313
Query: 333 VGGS 336
G S
Sbjct: 1314 AGQS 1317
Score = 37.7 bits (86), Expect = 0.019
Identities = 67/315 (21%), Positives = 104/315 (33%), Gaps = 80/315 (25%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVA--RVL 79
G +T +G+PL L C+ A P ++W Q G P + +A +V
Sbjct: 1695 GLGQVTTIVGQPLELPCQ-ASGSPVPTIQWL--------------QNGRPAEELAGVQVA 1739
Query: 80 PNGS-LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 138
G+ L + V + G+F CQA N G + +E+ V
Sbjct: 1740 SQGTTLHIDHVELDHSGLFACQATNEAG---------------------TAGAEVEVSVH 1778
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLF-------TLQSE 191
+ V E P G W + P V HP+ L +L E
Sbjct: 1779 GEWAPGVLE--VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE 1836
Query: 192 LMVTPARGGDPRP------------TFSCSFS--PGLPRHRALRTAPIQPRVWEPVPLEE 237
P P P ++C+ + G + + P + EP P+ +
Sbjct: 1837 PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNI-EPGPVNK 1895
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPE 290
AV +VTL C P P + W K P+ VL + +
Sbjct: 1896 ----------AVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 1945
Query: 291 IGPQDQGTYSCVATH 305
D G+Y CVA++
Sbjct: 1946 AQLSDAGSYRCVASN 1960
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 77.8 bits (190), Expect = 2e-14
Identities = 86/304 (28%), Positives = 124/304 (40%), Gaps = 53/304 (17%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVG 90
G+ + L C+ A +PP + W L G SP G + L GSL L +
Sbjct: 1950 GQEVRLDCE-ADGQPPPDVAW-LKDG--------SPLGQDMGPHLRFYLDGGSLVLKGLR 1999
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT--CVSEG 148
D G + C A N G++ + + V V P + D + L + P ++ T C G
Sbjct: 2000 ASDAGAYTCVAHNPAGEDARL-HTVNVLVPPTIKQGADGSGTLVSR-PGELVTMVCPVRG 2057
Query: 149 SYPAGTLSWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 202
S P +SW DG PL +++ G +++ + + G+FT + +PA D
Sbjct: 2058 SPPIH-VSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC---VAASPAGVADR 2113
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
T P V EPV + +VV G V L CE
Sbjct: 2114 NFTLQVQVPP----------------VLEPVEFQNDVVVVR--------GSLVELPCEAR 2149
Query: 263 AQPSPQIHWMKDGVPL---PLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSIS 319
P P + WMKDG PL L P L L +G D GTYSCVA S + R ++
Sbjct: 2150 GVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAV--SEAGEARRHFQLT 2207
Query: 320 IIEP 323
++EP
Sbjct: 2208 VMEP 2211
Score = 73.9 bits (180), Expect = 2e-13
Identities = 92/328 (28%), Positives = 127/328 (38%), Gaps = 62/328 (18%)
Query: 25 NITARIGEPLVLKCK--GAPK------KPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVA 76
N+T P +L C+ G+PK K Q+L+++L G
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG------------------AY 2531
Query: 77 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAG 136
R+LP+ +L L A G QD F C N G E Y+V V+ +P P I D ++ T
Sbjct: 2532 RLLPSNALLLTAPGPQDSAQFECVVSNEVG-EAHRLYQVTVH-VP--PTIADDQTDFTVT 2587
Query: 137 VPNKVG-TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
+ V TC S G PA T+SW G L G V +G + L
Sbjct: 2588 MMAPVVLTCHSTG-IPAPTVSWSKAGAQLGARGSGYRVS-------PSGALEIGQAL--- 2636
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTV 255
P G R T S S G+ T P V +P+P V+ V E E V
Sbjct: 2637 PIHAG--RYTCSARNSAGVAHKHVFLTVQASP-VVKPLP-SVVRAVAEEE---------V 2683
Query: 256 TLTCEVPAQPSPQIHWMKD------GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHG 309
L CE P P I W K+ GV + P L + P+D G Y C+A +S+
Sbjct: 2684 LLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743
Query: 310 PQESRAVSISIIEPGEEG-PTAGSVGGS 336
+ + + E G P + GS
Sbjct: 2744 AMGKTRLVVQVPPVIENGLPDLSTTEGS 2771
Score = 70.9 bits (172), Expect = 2e-12
Identities = 89/346 (25%), Positives = 138/346 (39%), Gaps = 53/346 (15%)
Query: 11 VLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGG 70
+LVL ++ + G +++ R+G+ L L+C A P R+ W +N + +S Q GG
Sbjct: 2843 ILVLPVFTTLPGDRSL--RLGDRLWLRC-AARGSPTPRIGWTVND--RPVTEGVSEQDGG 2897
Query: 71 PWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSA 130
+L AV +D G + C A NR G+ ++ V V + P ++
Sbjct: 2898 -----------STLQRAAVSREDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQG--EAF 2943
Query: 131 SELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ 189
S L V + CV G P + W DG PL +G ++ Q LQ
Sbjct: 2944 SYLVEPVGGSIQLDCVVRGD-PVPDIHWIKDGLPL----RGSHLRHQ-----------LQ 2987
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
+ + D + C L + + V + P+ +V EP+ V
Sbjct: 2988 NGSLTIRRTERDDAGRYQC-----LAENEMGVAKKVVILVLQSAPVFQV----EPQDMTV 3038
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLP------PSPVLILPEIGPQDQGTYSCVA 303
G V L C+ +P+P I W++ G PL P L L + D GTY CVA
Sbjct: 3039 RSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 3098
Query: 304 THSSHGPQESRAVSISIIEP-GEEGPTAGSVGGSGLGTLALALGIL 348
H+ G +RA + EP G G G + G G L ++
Sbjct: 3099 -HNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVM 3143
Score = 62.0 bits (149), Expect = 9e-10
Identities = 80/327 (24%), Positives = 125/327 (38%), Gaps = 86/327 (26%)
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS----ELTAGVP 138
SL L AVG D G + C A++ G E + ++++ V + P I DS LT G P
Sbjct: 2175 SLQLEAVGAGDSGTYSCVAVSEAG-EARRHFQLTVME---PPHIEDSGQPTELSLTPGAP 2230
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE------- 191
++ C ++G+ P ++WH DG+ L E S + R + GL+T +E
Sbjct: 2231 MEL-LCDAQGT-PQPNITWHKDGQALTRLENN-SRATRVLRVRDAGLYTCLAESPAGAIE 2287
Query: 192 ------LMVTPARGGDPRPTFSCSFSPG-LPRHRALRTAPIQPRVW--EPVPLEEVQLVV 242
+ P G P F +PG L ++ P W + + L+E
Sbjct: 2288 KSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQ 2347
Query: 243 EPEGGA------------------------------------------------VAPGGT 254
PE G V+ T
Sbjct: 2348 FPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQT 2407
Query: 255 VTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVL-ILPE-------IGPQDQGTYSCVATHS 306
L C+ P+P + W KD VPL P SP ILPE + QD G Y C+A++S
Sbjct: 2408 ALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2466
Query: 307 SHGPQESRAVSISIIEPGEEGPTAGSV 333
+ ++ R + ++EP P+ ++
Sbjct: 2467 AGSDRQGR--DLRVLEPPAIAPSPSNL 2491
Score = 58.9 bits (141), Expect = 8e-09
Identities = 73/312 (23%), Positives = 123/312 (39%), Gaps = 50/312 (16%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPN 81
G+ + +R GE + + C PP + W + G P R L +
Sbjct: 2037 GSGTLVSRPGELVTMVCP-VRGSPPIHVSWL--------------KDGLPLPLSQRTLLH 2081
Query: 82 GS---LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 138
GS L + V + D GIF C A + G + N+ ++V Q+P E V+ +++
Sbjct: 2082 GSGHTLRISKVQLADAGIFTCVAASPAGVADR-NFTLQV-QVPPVLEPVEFQNDVVVVRG 2139
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPN--EKGVSVKEQTRRHPETGLFTLQSELMVTP 196
+ V P +SW DG+PL+ E+G S++ + ++G ++ V
Sbjct: 2140 SLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC-----VAV 2194
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
+ G+ R F Q V EP +E+ +P ++ PG +
Sbjct: 2195 SEAGEARRHF-------------------QLTVMEPPHIEDSG---QPTELSLTPGAPME 2232
Query: 257 LTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAV 316
L C+ P P I W KDG L + + +D G Y+C+A + ++S V
Sbjct: 2233 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2292
Query: 317 SISIIEPGEEGP 328
+ P GP
Sbjct: 2293 RVQ-APPNIVGP 2303
Score = 58.2 bits (139), Expect = 1e-08
Identities = 83/336 (24%), Positives = 132/336 (39%), Gaps = 60/336 (17%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ R+G+ VL C+ P +K A + + +GG L
Sbjct: 1760 VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ------------RLE 1807
Query: 86 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNK--VGT 143
+ + D+G++ C+ N G+ ++ + + V Q+P P + +E + V V T
Sbjct: 1808 IQEAQVSDKGLYSCKVSNVAGEAVRT-FTLTV-QVP--PTFENPKTETVSQVAGSPLVLT 1863
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPR 203
C G PA T++W D P+ + +V R L LQ PA+ G
Sbjct: 1864 CDVSG-VPAPTVTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQ------PAQAG--- 1909
Query: 204 PTFSC--SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
T++C + R + + PR+ E V G V L CE
Sbjct: 1910 -TYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH---------VLEGQEVRLDCEA 1959
Query: 262 PAQPSPQIHWMKDGVPLPLPPSP---------VLILPEIGPQDQGTYSCVATHSSHGPQE 312
QP P + W+KDG PL P L+L + D G Y+CVA H+ G ++
Sbjct: 1960 DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA-HNPAG-ED 2017
Query: 313 SRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGIL 348
+R +++++ P PT G G GTL G L
Sbjct: 2018 ARLHTVNVLVP----PTI-KQGADGSGTLVSRPGEL 2048
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/247 (22%), Positives = 103/247 (41%), Gaps = 33/247 (13%)
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE-LTAGVPNKV 141
+L L + D G++ C+A+N G++ K ++ V P + + + V +K
Sbjct: 1710 TLQLGRARLSDSGMYTCEALNAAGRDQKL-VQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 1768
Query: 142 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
+ P T++W+ DG+PLV ++ +++ R L + A+ D
Sbjct: 1769 VLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR-------------LEIQEAQVSD 1815
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQ-PRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCE 260
+ +SC S T +Q P +E E V V G + LTC+
Sbjct: 1816 -KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVA---------GSPLVLTCD 1865
Query: 261 VPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
V P+P + W+KD +P+ + L L + P GTY+CVA ++ ++
Sbjct: 1866 VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKD 1925
Query: 314 RAVSISI 320
V++ +
Sbjct: 1926 FVVAVLV 1932
Score = 56.2 bits (134), Expect = 5e-08
Identities = 82/339 (24%), Positives = 125/339 (36%), Gaps = 74/339 (21%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQG--GGPWD------SVA 76
N++ G+ L L+C A P + W +A V P G G WD
Sbjct: 27 NVSGMAGQSLTLECD-ANGFPVPEIVWL-----KDAQLVGVPLGWAGYGWDLGWGQVGGH 80
Query: 77 RVLPNG-SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA 135
R+L G SL P + D G++ C+A N+ G + + + ++ S L A
Sbjct: 81 RLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLL----------VLTPPSVLGA 130
Query: 136 GVPNKVG---------TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLF 186
G +V C + G P + W D +P++P + V+E +
Sbjct: 131 GAAQEVLGLAGADVELQCWTSG-VPTPQVEWTKDRQPVLPGGPHLQVQEDGQ-------- 181
Query: 187 TLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRT---APIQPRVWEPVPLEEVQLVVE 243
L +T + GD +FSP + R + AP P +W EV
Sbjct: 182 ----VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP--PTIWGSNETGEV----- 230
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPV-------LILPEIGPQDQ 296
AV V L CE P+P I W KDG LP V L L D
Sbjct: 231 ----AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDA 286
Query: 297 GTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGG 335
G Y+C A+++ +++ + + + PT GG
Sbjct: 287 GVYTCKASNAVGAAEKATRLDVYV------PPTIEGAGG 319
Score = 56.2 bits (134), Expect = 5e-08
Identities = 71/290 (24%), Positives = 108/290 (37%), Gaps = 43/290 (14%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSL 84
NITA + PL L C+ A PP + W + P + + L
Sbjct: 1079 NITAALHSPLTLLCE-AMGIPPPAIRW-----------FRGEEPVSPGEDTYLLAGGWML 1126
Query: 85 FLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGT 143
+ QD G++ C A N G E + N+ V V P + E ++ ++ G +
Sbjct: 1127 KMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 1185
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKG-VSVKEQTRRHPETGLFTLQSELMVTPARGGDP 202
V+ +P L+W DG+PL + +S + + L + + G+
Sbjct: 1186 NVT--GHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1243
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
F S + AP E EEV + V ++L CE
Sbjct: 1244 TKHFQLS----------VLLAPTILGGAEDSADEEVTVTVN---------NPISLICEAL 1284
Query: 263 AQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATH 305
A PSP I WMKDG P LP + L + +D G Y+CV T+
Sbjct: 1285 AFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 1334
Score = 55.8 bits (133), Expect = 7e-08
Identities = 82/285 (28%), Positives = 109/285 (38%), Gaps = 53/285 (18%)
Query: 32 EPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWD-SVARVLPNGSLFLPAVG 90
+P V + GA KPP E W G P VA LP L + V
Sbjct: 526 DPPVHRGWGAHPKPPL----------VEGWCSPGSLWGEPTGIPVAYSLPP-PLQIEKVD 574
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGTCVSEGS 149
++DEGI+ C A N G E+K ++V P +P V+ A A V + C++ G
Sbjct: 575 LRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLE---CLASG- 629
Query: 150 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 209
P +SW +P V + GV+V R L + A+ D ++ C
Sbjct: 630 VPPPDVSWFKGHQP-VSSWMGVTVSVDGR------------VLRIEQAQLSDAG-SYRCV 675
Query: 210 FS--PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP 267
S G R + PR+ P L LV P V LTC PSP
Sbjct: 676 ASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP----------VRLTCNATGAPSP 725
Query: 268 QIHWMKDGVPLP---------LPPSPVLILPEIGPQDQGTYSCVA 303
+ W+KDG P+ P VL L D G YSCVA
Sbjct: 726 TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVA 770
Score = 55.8 bits (133), Expect = 7e-08
Identities = 74/323 (22%), Positives = 121/323 (37%), Gaps = 43/323 (13%)
Query: 11 VLVLSLWGAVVGAQ-NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGG 69
VL + + +++G + N++ E + L+C+ PP WK GR L P+ G
Sbjct: 782 VLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK--DGRP-----LEPRPG 834
Query: 70 GPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS 129
V L + + D G + C+A+N+ G K +Y + V+ P P
Sbjct: 835 -----VHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEK-HYNLNVWVAPVFPLRESH 888
Query: 130 ASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQ 189
+ G P ++ +C G P +SW DG+PL G+ R L+ Q
Sbjct: 889 TLTVREGHPTRL-SCECRG-VPFPKISWRKDGQPLPGEGAGLQHVSAVGRL----LYLGQ 942
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
++L + T CS G + P++ P P +V
Sbjct: 943 AQL------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE--------PPTQVSV 988
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLP-------PSPVLILPEIGPQDQGTYSCV 302
G TL C +P P + W +DG P+ L + G YSCV
Sbjct: 989 VQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCV 1048
Query: 303 ATHSSHGPQESRAVSISIIEPGE 325
A + + + R +S++ P E
Sbjct: 1049 AENLA--GRAERKFELSVLVPPE 1069
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/249 (26%), Positives = 100/249 (40%), Gaps = 49/249 (19%)
Query: 78 VLPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIP---GKPEIVDSASE- 132
+ P+G L + + G + C A N G++TK ++++ V P G E DSA E
Sbjct: 1212 ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTK-HFQLSVLLAPTILGGAE--DSADEE 1268
Query: 133 LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKP--------LVPNEKGVSVKEQTRRHPETG 184
+T V N + ++P+ ++W DG P L+P G+ + +
Sbjct: 1269 VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQY 1328
Query: 185 LFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEP 244
+ +EL G+ + I P + + PL EV +
Sbjct: 1329 TCVVTNEL-------GEAVKNYHVEVL-------------IPPSISKDDPLAEVGV---- 1364
Query: 245 EGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPE-----IGP---QDQ 296
+ T+TL CE A P P I W KDG P+ P S + +L E I P D
Sbjct: 1365 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQIQPTQVSDS 1423
Query: 297 GTYSCVATH 305
G Y CVAT+
Sbjct: 1424 GRYLCVATN 1432
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/311 (24%), Positives = 125/311 (40%), Gaps = 51/311 (16%)
Query: 2 AAGTAVGAWVLVLSLWGAVV-GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
+AG+A+G LV+ + + G +++ G L CK A P + W
Sbjct: 2740 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK-ARGSPEPNITWD-------- 2790
Query: 61 WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI 120
K P G + + P+G L + + QD G + C A N G+ + RV + I
Sbjct: 2791 -KDGQPVSGA--EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR---RVHL-TI 2843
Query: 121 PGKPEIVDSASELTAGVPNKVGT-CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRR 179
P + + + +++ C + GS P + W ++ +P+ +GVS ++
Sbjct: 2844 LVLPVFTTLPGDRSLRLGDRLWLRCAARGS-PTPRIGWTVNDRPVT---EGVSEQD---- 2895
Query: 180 HPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEV- 238
G TLQ + G T+ C + R +A+ ++ PV E
Sbjct: 2896 ----GGSTLQRAAVSREDSG-----TYVCWAENRVGRTQAVSFVHVKEA---PVLQGEAF 2943
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPL------PLPPSPVLILPEIG 292
+VEP GG++ L C V P P IHW+KDG+PL + L +
Sbjct: 2944 SYLVEPVGGSIQ------LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTE 2997
Query: 293 PQDQGTYSCVA 303
D G Y C+A
Sbjct: 2998 RDDAGRYQCLA 3008
Score = 50.4 bits (119), Expect = 3e-06
Identities = 77/286 (26%), Positives = 105/286 (36%), Gaps = 55/286 (19%)
Query: 77 RVLPNGS-LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA 135
+V P G L L + D G + C A++ G++ + V Q+ P I+ ++
Sbjct: 745 QVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV----VLQVHMPPSILGEELNVSV 800
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
V + P LSW DG+PL P P L ++ L V
Sbjct: 801 VANESVALECQSHAMPPPVLSWWKDGRPLEPR-------------PGVHLSADKALLQVD 847
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPR-----VW-EPV-PLEEVQLVVEPEGGA 248
A D ++C AL A + VW PV PL E +
Sbjct: 848 RADVWDAGH-YTCE---------ALNQAGHSEKHYNLNVWVAPVFPLRESHTLT------ 891
Query: 249 VAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP---------LPPSPVLILPEIGPQDQGTY 299
V G L+CE P P+I W KDG PLP +L L + +GTY
Sbjct: 892 VREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTY 951
Query: 300 SC----VATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTL 341
+C V +SS Q V I P E PT SV G+ TL
Sbjct: 952 TCECSNVVGNSSQDLQLEVHVPPQIAGP-REPPTQVSVVQDGVATL 996
Score = 50.1 bits (118), Expect = 4e-06
Identities = 58/230 (25%), Positives = 94/230 (40%), Gaps = 45/230 (19%)
Query: 93 DEGIFRCQAMNRNGKETKSNYRVRVYQIP------GKPEIVDSASELTAGVPNKVGTCVS 146
D G++ C+A N G K+ R+ VY P G+P +V + AG P + CV+
Sbjct: 285 DAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAV----AGRPVAL-ECVA 338
Query: 147 EGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTF 206
G +P+ TLSWH +G P V+ ++R + + L+S G +
Sbjct: 339 RG-HPSPTLSWHHEGLP-------VAESNESRLETDGSVLRLESP-------GEASSGLY 383
Query: 207 SCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP--GGTVTLTCEVPAQ 264
SC S P A+ ++ +V QL+V G V G + L C+
Sbjct: 384 SCVASS--PAGEAVLQYSVEVQV-------PPQLLVAEGLGQVTTIVGQPLELPCQASGS 434
Query: 265 PSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSS 307
P P I W+++G P L + + G ++C AT+ +
Sbjct: 435 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484
Score = 48.9 bits (115), Expect = 8e-06
Identities = 64/241 (26%), Positives = 94/241 (39%), Gaps = 40/241 (16%)
Query: 78 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE--LTA 135
+LP GSL + V QD G + C A N G + + R ++ P I S S LTA
Sbjct: 2440 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG----RDLRVLEPPAIAPSPSNLTLTA 2495
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
P + C + GS P + W DG+ L R + L S ++
Sbjct: 2496 HTPALL-PCEASGS-PKPLVVWWKDGQKL------------DFRLQQGAYRLLPSNALLL 2541
Query: 196 PARGGDPRPTFSCSFSPGL-PRHRALR-TAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGG 253
A G F C S + HR + T + P + + ++ V +AP
Sbjct: 2542 TAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD----DQTDFTVT----MMAP-- 2591
Query: 254 TVTLTCEVPAQPSPQIHWMKDGVPL-------PLPPSPVLILPEIGPQDQGTYSCVATHS 306
V LTC P+P + W K G L + PS L + + P G Y+C A +S
Sbjct: 2592 -VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS 2650
Query: 307 S 307
+
Sbjct: 2651 A 2651
Score = 48.5 bits (114), Expect = 1e-05
Identities = 64/284 (22%), Positives = 103/284 (36%), Gaps = 53/284 (18%)
Query: 36 LKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEG 95
L+C A KPP + W+ + A L Q G SL + G
Sbjct: 996 LECN-ATGKPPPTVTWERDGQPVGAELGLQLQNQGQ-----------SLHVERAQAAHTG 1043
Query: 96 IFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTL 155
+ C A N G+ + + + V P +D + +TA + + + P +
Sbjct: 1044 RYSCVAENLAGRAERK-FELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAI 1102
Query: 156 SWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCS 209
W +P+ P E G +K + ++GL++ + G+ R FS
Sbjct: 1103 RWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVE 1157
Query: 210 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 269
+ P E LEEV V++ G T L C V P P++
Sbjct: 1158 V--------------LVPPSIENEDLEEVIKVLD--------GQTAHLMCNVTGHPQPKL 1195
Query: 270 HWMKDGVPLP------LPPSPVLI-LPEIGPQDQGTYSCVATHS 306
W KDG PL + P VL+ + + G YSC+A ++
Sbjct: 1196 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANA 1239
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/245 (25%), Positives = 98/245 (40%), Gaps = 35/245 (14%)
Query: 72 WDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSA- 130
W V + L + + D G +RC A N G T+ Y +RV +P + + S
Sbjct: 647 WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS-TELRYGLRV-NVPPRITLPPSLP 704
Query: 131 SELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP-NEKGVSVKEQTRRHPETGLFTLQ 189
+ P ++ TC + G+ P+ TL W DG P+ P G+ V P + TL
Sbjct: 705 GPVLVNTPVRL-TCNATGA-PSPTLMWLKDGNPVSPAGTPGLQV------FPGGRVLTLA 756
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
S AR D +SC + R + +Q + + EE+ + +V
Sbjct: 757 S------ARASDSG-RYSCVAVSAVGEDR--QDVVLQVHMPPSILGEELNV-------SV 800
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPP-------SPVLILPEIGPQDQGTYSCV 302
+V L C+ A P P + W KDG PL P +L + D G Y+C
Sbjct: 801 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCE 860
Query: 303 ATHSS 307
A + +
Sbjct: 861 ALNQA 865
Score = 47.4 bits (111), Expect = 2e-05
Identities = 70/291 (24%), Positives = 115/291 (39%), Gaps = 48/291 (16%)
Query: 67 QGGGPWDSVAR--VLPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGK 123
Q G P+ R VL +G + + + D + C A N+ G K + +RV Q+P +
Sbjct: 1599 QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKL-FTLRV-QVPPR 1656
Query: 124 PEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEK-----GVSVKEQTR 178
+D ++TA + + V ++P ++W+ D + L E+ G + R
Sbjct: 1657 IAGLD-LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGR 1715
Query: 179 -RHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEE 237
R ++G++T ++ A G D + P A R AP P+
Sbjct: 1716 ARLSDSGMYTCEA----LNAAGRDQKLVQLSVLVPP-----AFRQAPRGPQ--------- 1757
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPP-------SPVLILPE 290
+ V G L+CE A P P + W KDG PL L L + E
Sbjct: 1758 -------DAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 1810
Query: 291 IGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGP---TAGSVGGSGL 338
D+G YSC ++ + + +++ + P E P T V GS L
Sbjct: 1811 AQVSDKGLYSCKVSNVAGEAVRTFTLTVQ-VPPTFENPKTETVSQVAGSPL 1860
Score = 45.4 bits (106), Expect = 9e-05
Identities = 75/334 (22%), Positives = 130/334 (38%), Gaps = 70/334 (20%)
Query: 14 LSLWGAVV----GAQNITARIGEP--LVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQ 67
L++W A V + +T R G P L +C+G P ++ W+ + + L +
Sbjct: 874 LNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFP---KISWRKDG------QPLPGE 924
Query: 68 GGGPW--DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVY---QIPG 122
G G +V R+L +L + EG + C+ N G ++ + ++ V+ QI G
Sbjct: 925 GAGLQHVSAVGRLL-----YLGQAQLAQEGTYTCECSNVVGNSSQ-DLQLEVHVPPQIAG 978
Query: 123 KPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKP------LVPNEKGVSVKEQ 176
E S + GV C + G P T++W DG+P L +G S+ +
Sbjct: 979 PREPPTQVSVVQDGVATL--ECNATGK-PPPTVTWERDGQPVGAELGLQLQNQGQSLHVE 1035
Query: 177 TRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLE 236
+ TG ++ +E + A + + S P L + + PL
Sbjct: 1036 RAQAAHTGRYSCVAENLAGRA---ERKFELSVLVPPEL--------------IGDLDPLT 1078
Query: 237 EVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILP 289
+ + +TL CE P P I W + P+ L +L +
Sbjct: 1079 NITAALH---------SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMT 1129
Query: 290 EIGPQDQGTYSCVATHSSHGPQESRAVSISIIEP 323
+ QD G YSC+A S+ + R S+ ++ P
Sbjct: 1130 QTQEQDSGLYSCLA--SNEAGEARRNFSVEVLVP 1161
Score = 44.7 bits (104), Expect = 2e-04
Identities = 75/332 (22%), Positives = 124/332 (37%), Gaps = 68/332 (20%)
Query: 19 AVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARV 78
A VG + + ++ L L+C+ PP +K T + ++ +V
Sbjct: 1360 AEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL-------------QV 1406
Query: 79 LPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKS-NYRVRVYQIPGKP-------EIVDS 129
L G L + + D G + C A N G++ + N ++V + K EI+
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1466
Query: 130 ASELTAGVP--------NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHP 181
E GV N + P L+W+ + +PL ++ VSV + R
Sbjct: 1467 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE-VSVLQGGR--- 1522
Query: 182 ETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPR----HRALRTAPIQPRVWEPVPLEE 237
LQ L+ G +SC S + + L P PV L +
Sbjct: 1523 -----VLQIPLVRAENAG-----RYSCKASNEVGEDWLHYELLVLTP-------PVILGD 1565
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGP---- 293
+ +VE V TV+L C P P I W+++G LP PSP L + E G
Sbjct: 1566 TEELVEEV--TVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQV 1621
Query: 294 -----QDQGTYSCVATHSSHGPQESRAVSISI 320
D +Y CVA + + ++ + + +
Sbjct: 1622 STAEVADAASYMCVAENQAGSAEKLFTLRVQV 1653
Score = 43.5 bits (101), Expect = 3e-04
Identities = 83/339 (24%), Positives = 136/339 (40%), Gaps = 49/339 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ A G P+ L+C A P L W E V + +R+ +GS+
Sbjct: 324 VKAVAGRPVALECV-ARGHPSPTLSW-----HHEGLPVAE-------SNESRLETDGSVL 370
Query: 86 -LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA--GVPNKVG 142
L + G G++ C A + G E Y V V Q+P + + + ++T G P ++
Sbjct: 371 RLESPGEASSGLYSCVASSPAG-EAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLEL- 427
Query: 143 TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQ-TRRHPE------TGLFTLQSELMVT 195
C + GS P T+ W +G+P GV V Q T H + +GLF Q+
Sbjct: 428 PCQASGS-PVPTIQWLQNGRP-AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 485
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEP---EGGAVAPG 252
A G + + ++PG+ PI W +P G P
Sbjct: 486 TA-GAEVEVSVHGEWAPGVLE------VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPK 538
Query: 253 GTVTLTCEVPAQPSPQIHWMKD-GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQ 311
+ V SP W + G+P+ P L + ++ +D+G Y+C AT+ + +
Sbjct: 539 PPL-----VEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLA--GE 591
Query: 312 ESRAVSISIIEPG--EEGPTAGSVGGSGLGTL-ALALGI 347
R V++ ++ P E GP +V + TL LA G+
Sbjct: 592 SKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGV 630
Score = 37.7 bits (86), Expect = 0.019
Identities = 67/315 (21%), Positives = 104/315 (33%), Gaps = 80/315 (25%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVA--RVL 79
G +T +G+PL L C+ A P ++W Q G P + +A +V
Sbjct: 413 GLGQVTTIVGQPLELPCQ-ASGSPVPTIQWL--------------QNGRPAEELAGVQVA 457
Query: 80 PNGS-LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVP 138
G+ L + V + G+F CQA N G + +E+ V
Sbjct: 458 SQGTTLHIDHVELDHSGLFACQATNEAG---------------------TAGAEVEVSVH 496
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLF-------TLQSE 191
+ V E P G W + P V HP+ L +L E
Sbjct: 497 GEWAPGVLE--VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE 554
Query: 192 LMVTPARGGDPRP------------TFSCSFS--PGLPRHRALRTAPIQPRVWEPVPLEE 237
P P P ++C+ + G + + P + EP P+ +
Sbjct: 555 PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNI-EPGPVNK 613
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPE 290
AV +VTL C P P + W K P+ VL + +
Sbjct: 614 ----------AVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 663
Query: 291 IGPQDQGTYSCVATH 305
D G+Y CVA++
Sbjct: 664 AQLSDAGSYRCVASN 678
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 73.9 bits (180), Expect = 2e-13
Identities = 78/328 (23%), Positives = 126/328 (38%), Gaps = 55/328 (16%)
Query: 15 SLWGAVVGAQNITARI-----------GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKV 63
SL G+ VG ++ RI GEP L C+ A +P +EW N R +
Sbjct: 51 SLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCR-AEGRPRPNIEWYKNGARVATVRE 109
Query: 64 LSPQGGGPWDSVARVLPNGSLFLPAV-----GIQDEGIFRCQAMNRNGKETKSNYRVRVY 118
P+ +LP+G+LF P + DEG++ C A N G N + V
Sbjct: 110 -DPRAH------RLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVA 162
Query: 119 QIPGKPEIVDSASELTAGVPNK-VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQT 177
+ + + S + V V CV +P ++SW DG L E ++++
Sbjct: 163 VL--RDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG-- 218
Query: 178 RRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEE 237
+LM++ D + + R A E + LE
Sbjct: 219 ------------GKLMMSHTLKSDAGMYVCVASNMAGERESAAA---------EVMVLER 257
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP-----LPPSPVLILPEIG 292
+ P V VT CEV P P++ W K+ LP + L + +
Sbjct: 258 PSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVS 317
Query: 293 PQDQGTYSCVATHSSHGPQESRAVSISI 320
+D+GTY+CVA +S + S ++S+ +
Sbjct: 318 AEDEGTYTCVAENSVGRAEASGSLSVHV 345
Score = 55.1 bits (131), Expect = 1e-07
Identities = 78/354 (22%), Positives = 127/354 (35%), Gaps = 73/354 (20%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARV-LPNGS 83
N+ +GEP VL+C P + W+ + R + + R+ + G
Sbjct: 174 NVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLK-------------EEEGRITIRGGK 220
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT 143
L + D G++ C A N G+ + V V + P + +++
Sbjct: 221 LMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSF--LRRPVNQVVLADAPVTFL 278
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPAR-GGDP 202
C +G P L W + L TG + ++S+ + +
Sbjct: 279 CEVKGD-PPPRLRWRKEDGEL-----------------PTGRYEIRSDHSLWIGHVSAED 320
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
T++C + R A + + VP QLV +P+ APG +V CE
Sbjct: 321 EGTYTCVAENSVGRAEASGSLSVH------VP---PQLVTQPQDQMAAPGESVAFQCETK 371
Query: 263 AQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIE 322
P P I W K+G S VL+ P Q G +S S G ++I+ ++
Sbjct: 372 GNPPPAIFWQKEG-------SQVLLFPSQSLQPTGRFSV----SPRG-----QLNITAVQ 415
Query: 323 PGEEG---PTAGSVGGSGLGTLALALG----------ILGGLGTAALLIGVILW 363
G+ G A SV GS L L + IL G L++G +W
Sbjct: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVW 469
Score = 52.0 bits (123), Expect = 1e-06
Identities = 63/276 (22%), Positives = 102/276 (36%), Gaps = 46/276 (16%)
Query: 45 PPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNR 104
PP RL W+ G + + + SL++ V +DEG + C A N
Sbjct: 285 PPPRLRWRKEDGELPTGRY-------------EIRSDHSLWIGHVSAEDEGTYTCVAENS 331
Query: 105 NGK-ETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG-TCVSEGSYPAGTLSWHLDGK 162
G+ E + V V P++V + A V C ++G+ P + W +G
Sbjct: 332 VGRAEASGSLSVHV-----PPQLVTQPQDQMAAPGESVAFQCETKGN-PPPAIFWQKEGS 385
Query: 163 P--LVPNEKGVSVKEQTRRHPETGLFTL--QSELMVTPARGGDPRPTFSCSFSPGLPRHR 218
L P++ TG F++ + +L +T + GD + C
Sbjct: 386 QVLLFPSQS----------LQPTGRFSVSPRGQLNITAVQRGDAG-YYVCQAVSVAGSIL 434
Query: 219 ALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDG--- 275
A I+ + +P +Q P + G +V L C V P P + W KDG
Sbjct: 435 AKALLEIKGASLDGLPPVILQ---GPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWL 491
Query: 276 ----VPLPLPPSPVLILPEIGPQDQGTYSCVATHSS 307
+ + L + + D G YSCVA S+
Sbjct: 492 QGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSST 527
Score = 29.3 bits (64), Expect = 6.6
Identities = 23/96 (23%), Positives = 37/96 (38%), Gaps = 20/96 (20%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPW----DSVAR 77
G N T +G + L C+ P + WK + G W D +
Sbjct: 456 GPANQTLVLGSSVWLPCR-VTGNPQPSVRWKKD---------------GQWLQGDDLQFK 499
Query: 78 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNY 113
+ NG+L++ V D G + C A + G+ T S +
Sbjct: 500 TMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGW 535
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 72.8 bits (177), Expect = 5e-13
Identities = 78/318 (24%), Positives = 120/318 (37%), Gaps = 52/318 (16%)
Query: 20 VVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVL 79
V+ QN +GE + L+C A PP R+ W RT P D +
Sbjct: 345 VIQPQNTEVLVGESVTLECS-ATGHPPPRISWTRGD-RTPL----------PVDPRVNIT 392
Query: 80 PNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPN 139
P+G L++ V D G + C A N + + IV + + T +
Sbjct: 393 PSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFI-----------IVQALPQFTVTPQD 441
Query: 140 KVGTCVSEGSYPAGTLSWHLDGK----PLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
+V V EG T+ + + K P++ KG S RRH TL+ +
Sbjct: 442 RV---VIEGQ----TVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVAL 494
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTV 255
+G + C + + + +QPRV PV P V G V
Sbjct: 495 HDQG-----QYECQAVNIIGSQKVVAHLTVQPRV-TPV------FASIPSDTTVEVGANV 542
Query: 256 TLTCEVPAQPSPQIHWMKDGVPLP------LPPSPVLILPEIGPQDQGTYSCVATHSSHG 309
L C +P P I W KDGV + + P L + ++GP D G Y CVA ++
Sbjct: 543 QLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGS 602
Query: 310 PQESRAVSISIIEPGEEG 327
S +S+++ + G
Sbjct: 603 ASVSMVLSVNVPDVSRNG 620
Score = 61.6 bits (148), Expect = 1e-09
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 73 DSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASE 132
DS +L +G+L + D+GI++C A N G+ +R + P +P V
Sbjct: 291 DSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQN 350
Query: 133 LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSEL 192
V V S +P +SW + +P + V++ P GL+
Sbjct: 351 TEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNIT------PSGGLYIQN--- 401
Query: 193 MVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPG 252
V G+ ++CS + + A TA I + + +P Q V P+ V G
Sbjct: 402 -VVQGDSGE----YACSATNNIDSVHA--TAFI---IVQALP----QFTVTPQDRVVIEG 447
Query: 253 GTVTLTCEVPAQPSPQIHWMKDGVPLPLP------PSPVLILPEIGPQDQGTYSCVATH 305
TV CE P P I W K G L + S L + + DQG Y C A +
Sbjct: 448 QTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVN 506
Score = 45.4 bits (106), Expect = 9e-05
Identities = 34/122 (27%), Positives = 49/122 (40%), Gaps = 14/122 (11%)
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
++L+ T A G+ + C + R + A I P E + E ++ EP+ V
Sbjct: 204 ADLLKTYAESGNAQAAAICEYPR---RIQGRSVATITP---EELNCERPRITSEPQDADV 257
Query: 250 APGGTVTLTCEVPAQPSPQIHW--------MKDGVPLPLPPSPVLILPEIGPQDQGTYSC 301
G TV TC P P+I W MK L L L++ DQG Y C
Sbjct: 258 TSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQC 317
Query: 302 VA 303
+A
Sbjct: 318 MA 319
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 72.0 bits (175), Expect = 9e-13
Identities = 77/308 (25%), Positives = 115/308 (37%), Gaps = 45/308 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV- 89
GEP L CK A +P +EW R E K P+ S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKD-DPR------SHRMLLPSGSLFFLRIV 94
Query: 90 ----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
DEG++ C A N G+ N + V + S + G P V C
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQ 153
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 205
+P T+SW DG PL ++ ++++ +LM+T R D
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKY 199
Query: 206 FSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
+ R + V E LE V P AV + CE P
Sbjct: 200 VCVGTNMVGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 266 SPQIHWMKDGVPLP-----LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
P + W KD LP + L + ++ D G+Y+CVA + + S +++ +
Sbjct: 251 VPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 321 IEPGEEGP 328
G E P
Sbjct: 311 ---GSEPP 315
Score = 52.8 bits (125), Expect = 6e-07
Identities = 58/254 (22%), Positives = 88/254 (34%), Gaps = 43/254 (16%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVAR--VLPNG 82
++ +GEP V++C+ P + WK + G P D + G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK--------------KDGSPLDDKDERITIRGG 184
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
L + D G + C N G+ + V + +P V S L V +
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAE 241
Query: 143 -TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C + G P T+ W D L + + R T L + GD
Sbjct: 242 FKCEARGD-PVPTVRWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD 285
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+++C + + A T +Q V E VV+P VA G TVT CE
Sbjct: 286 -MGSYTCVAENMVGKAEASATLTVQ------VGSEPPHFVVKPRDQVVALGRTVTFQCEA 338
Query: 262 PAQPSPQIHWMKDG 275
P P I W ++G
Sbjct: 339 TGNPQPAIFWRREG 352
Score = 36.2 bits (82), Expect = 0.054
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 7/71 (9%)
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQ-------DQ 296
P VA GT L+C P P I W KDGV + S + L Q D
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 484
Query: 297 GTYSCVATHSS 307
G Y+C+A+ S
Sbjct: 485 GRYTCIASTPS 495
Score = 33.9 bits (76), Expect = 0.27
Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL----PPSPVLILP----- 289
++V P V+ G TL C+ +P+P I W K G + P S ++LP
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 290 -------EIGPQDQGTYSCVA 303
D+G Y CVA
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVA 110
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 72.0 bits (175), Expect = 9e-13
Identities = 77/308 (25%), Positives = 115/308 (37%), Gaps = 45/308 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV- 89
GEP L CK A +P +EW R E K P+ S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKD-DPR------SHRMLLPSGSLFFLRIV 94
Query: 90 ----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
DEG++ C A N G+ N + V + S + G P V C
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQ 153
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 205
+P T+SW DG PL ++ ++++ +LM+T R D
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKY 199
Query: 206 FSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
+ R + V E LE V P AV + CE P
Sbjct: 200 VCVGTNMVGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 266 SPQIHWMKDGVPLP-----LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
P + W KD LP + L + ++ D G+Y+CVA + + S +++ +
Sbjct: 251 VPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 321 IEPGEEGP 328
G E P
Sbjct: 311 ---GSEPP 315
Score = 52.8 bits (125), Expect = 6e-07
Identities = 58/254 (22%), Positives = 88/254 (34%), Gaps = 43/254 (16%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVAR--VLPNG 82
++ +GEP V++C+ P + WK + G P D + G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK--------------KDGSPLDDKDERITIRGG 184
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
L + D G + C N G+ + V + +P V S L V +
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAE 241
Query: 143 -TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C + G P T+ W D L + + R T L + GD
Sbjct: 242 FKCEARGD-PVPTVRWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD 285
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+++C + + A T +Q V E VV+P VA G TVT CE
Sbjct: 286 -MGSYTCVAENMVGKAEASATLTVQ------VGSEPPHFVVKPRDQVVALGRTVTFQCEA 338
Query: 262 PAQPSPQIHWMKDG 275
P P I W ++G
Sbjct: 339 TGNPQPAIFWRREG 352
Score = 36.2 bits (82), Expect = 0.054
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 7/71 (9%)
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQ-------DQ 296
P VA GT L+C P P I W KDGV + S + L Q D
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 484
Query: 297 GTYSCVATHSS 307
G Y+C+A+ S
Sbjct: 485 GRYTCIASTPS 495
Score = 33.9 bits (76), Expect = 0.27
Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL----PPSPVLILP----- 289
++V P V+ G TL C+ +P+P I W K G + P S ++LP
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 290 -------EIGPQDQGTYSCVA 303
D+G Y CVA
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVA 110
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 72.0 bits (175), Expect = 9e-13
Identities = 77/308 (25%), Positives = 115/308 (37%), Gaps = 45/308 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV- 89
GEP L CK A +P +EW R E K P+ S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKD-DPR------SHRMLLPSGSLFFLRIV 94
Query: 90 ----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
DEG++ C A N G+ N + V + S + G P V C
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQ 153
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 205
+P T+SW DG PL ++ ++++ +LM+T R D
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKY 199
Query: 206 FSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
+ R + V E LE V P AV + CE P
Sbjct: 200 VCVGTNMVGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 266 SPQIHWMKDGVPLP-----LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
P + W KD LP + L + ++ D G+Y+CVA + + S +++ +
Sbjct: 251 VPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 321 IEPGEEGP 328
G E P
Sbjct: 311 ---GSEPP 315
Score = 52.8 bits (125), Expect = 6e-07
Identities = 58/254 (22%), Positives = 88/254 (34%), Gaps = 43/254 (16%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVAR--VLPNG 82
++ +GEP V++C+ P + WK + G P D + G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK--------------KDGSPLDDKDERITIRGG 184
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
L + D G + C N G+ + V + +P V S L V +
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAE 241
Query: 143 -TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C + G P T+ W D L + + R T L + GD
Sbjct: 242 FKCEARGD-PVPTVRWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD 285
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+++C + + A T +Q V E VV+P VA G TVT CE
Sbjct: 286 -MGSYTCVAENMVGKAEASATLTVQ------VGSEPPHFVVKPRDQVVALGRTVTFQCEA 338
Query: 262 PAQPSPQIHWMKDG 275
P P I W ++G
Sbjct: 339 TGNPQPAIFWRREG 352
Score = 36.2 bits (82), Expect = 0.054
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 7/71 (9%)
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQ-------DQ 296
P VA GT L+C P P I W KDGV + S + L Q D
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 484
Query: 297 GTYSCVATHSS 307
G Y+C+A+ S
Sbjct: 485 GRYTCIASTPS 495
Score = 33.9 bits (76), Expect = 0.27
Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL----PPSPVLILP----- 289
++V P V+ G TL C+ +P+P I W K G + P S ++LP
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 290 -------EIGPQDQGTYSCVA 303
D+G Y CVA
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVA 110
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 72.0 bits (175), Expect = 9e-13
Identities = 77/308 (25%), Positives = 115/308 (37%), Gaps = 45/308 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV- 89
GEP L CK A +P +EW R E K P+ S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKD-DPR------SHRMLLPSGSLFFLRIV 94
Query: 90 ----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
DEG++ C A N G+ N + V + S + G P V C
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQ 153
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 205
+P T+SW DG PL ++ ++++ +LM+T R D
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKY 199
Query: 206 FSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
+ R + V E LE V P AV + CE P
Sbjct: 200 VCVGTNMVGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 266 SPQIHWMKDGVPLP-----LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
P + W KD LP + L + ++ D G+Y+CVA + + S +++ +
Sbjct: 251 VPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 321 IEPGEEGP 328
G E P
Sbjct: 311 ---GSEPP 315
Score = 52.8 bits (125), Expect = 6e-07
Identities = 58/254 (22%), Positives = 88/254 (34%), Gaps = 43/254 (16%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVAR--VLPNG 82
++ +GEP V++C+ P + WK + G P D + G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK--------------KDGSPLDDKDERITIRGG 184
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
L + D G + C N G+ + V + +P V S L V +
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAE 241
Query: 143 -TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C + G P T+ W D L + + R T L + GD
Sbjct: 242 FKCEARGD-PVPTVRWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD 285
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+++C + + A T +Q V E VV+P VA G TVT CE
Sbjct: 286 -MGSYTCVAENMVGKAEASATLTVQ------VGSEPPHFVVKPRDQVVALGRTVTFQCEA 338
Query: 262 PAQPSPQIHWMKDG 275
P P I W ++G
Sbjct: 339 TGNPQPAIFWRREG 352
Score = 36.2 bits (82), Expect = 0.054
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 7/71 (9%)
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQ-------DQ 296
P VA GT L+C P P I W KDGV + S + L Q D
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 484
Query: 297 GTYSCVATHSS 307
G Y+C+A+ S
Sbjct: 485 GRYTCIASTPS 495
Score = 33.9 bits (76), Expect = 0.27
Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL----PPSPVLILP----- 289
++V P V+ G TL C+ +P+P I W K G + P S ++LP
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 290 -------EIGPQDQGTYSCVA 303
D+G Y CVA
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVA 110
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 70.5 bits (171), Expect = 3e-12
Identities = 78/303 (25%), Positives = 116/303 (38%), Gaps = 44/303 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV- 89
GEP L CK A +P +EW R E K P+ S +LP+GSLF +
Sbjct: 43 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKD-DPR------SHRMLLPSGSLFFLRIV 94
Query: 90 ----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
DEG++ C A N G+ N + V + S + G P V C
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQ 153
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 205
+P T+SW DG PL ++ ++++ +LM+T R D
Sbjct: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKY 199
Query: 206 FSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
+ R + V E LE V P AV + CE P
Sbjct: 200 VCVGTNMVGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 266 SPQIHWMKDGVPLP-----LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
P + W KD LP + L + ++ D G+Y+CVA + G E+ A ++++
Sbjct: 251 VPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA-ENMVGKAEASA-TLTV 308
Query: 321 IEP 323
EP
Sbjct: 309 QEP 311
Score = 51.6 bits (122), Expect = 1e-06
Identities = 57/254 (22%), Positives = 87/254 (34%), Gaps = 46/254 (18%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVAR--VLPNG 82
++ +GEP V++C+ P + WK + G P D + G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK--------------KDGSPLDDKDERITIRGG 184
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
L + D G + C N G+ + V + +P V S L V +
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAE 241
Query: 143 -TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C + G P T+ W D L + + R T L + GD
Sbjct: 242 FKCEARGD-PVPTVRWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD 285
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+++C + + A T +Q E VV+P VA G TVT CE
Sbjct: 286 -MGSYTCVAENMVGKAEASATLTVQ---------EPPHFVVKPRDQVVALGRTVTFQCEA 335
Query: 262 PAQPSPQIHWMKDG 275
P P I W ++G
Sbjct: 336 TGNPQPAIFWRREG 349
Score = 36.2 bits (82), Expect = 0.054
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 7/71 (9%)
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQ-------DQ 296
P VA GT L+C P P I W KDGV + S + L Q D
Sbjct: 422 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 481
Query: 297 GTYSCVATHSS 307
G Y+C+A+ S
Sbjct: 482 GRYTCIASTPS 492
Score = 33.9 bits (76), Expect = 0.27
Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL----PPSPVLILP----- 289
++V P V+ G TL C+ +P+P I W K G + P S ++LP
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 89
Query: 290 -------EIGPQDQGTYSCVA 303
D+G Y CVA
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVA 110
>gi|71274107 melanoma cell adhesion molecule [Homo sapiens]
Length = 646
Score = 70.5 bits (171), Expect = 3e-12
Identities = 64/229 (27%), Positives = 98/229 (42%), Gaps = 18/229 (7%)
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS--ASELTAGVPNK 140
+L L V QDE IF CQ +E + ++RVY+ P +P I + + + P +
Sbjct: 100 TLALTQVTPQDERIFLCQGKRPRSQEYR--IQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
Query: 141 VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGG 200
V TCV YP + W+ +G+PL + V + + ++ +GL+TLQS L +
Sbjct: 158 VATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHI-QSSQTVESSGLYTLQSILKAQLVK-E 215
Query: 201 DPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV--PLEEVQLVVEPEGGAVAPGGTVTLT 258
D F C + LP ++ + V PV P E+V L VEP G + G V +
Sbjct: 216 DKDAQFYCELNYRLPSGNHMKES---REVTVPVFYPTEKVWLEVEPV-GMLKEGDRVEIR 271
Query: 259 CEVPAQPSPQIHWMK------DGVPLPLPPSPVLILPEIGPQDQGTYSC 301
C P P K + + VL+L + G Y C
Sbjct: 272 CLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYEC 320
Score = 40.8 bits (94), Expect = 0.002
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 1/83 (1%)
Query: 242 VEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSC 301
V P G ++TLTCE + + W+++ L PVL L ++ + G Y C
Sbjct: 348 VSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRC 407
Query: 302 VAT-HSSHGPQESRAVSISIIEP 323
VA+ S G ++ V+++I P
Sbjct: 408 VASVPSIPGLNRTQLVNVAIFGP 430
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 70.5 bits (171), Expect = 3e-12
Identities = 78/303 (25%), Positives = 116/303 (38%), Gaps = 44/303 (14%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV- 89
GEP L CK A +P +EW R E K P+ S +LP+GSLF +
Sbjct: 82 GEPATLNCK-AEGRPTPTIEWYKGGERVETDKD-DPR------SHRMLLPSGSLFFLRIV 133
Query: 90 ----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
DEG++ C A N G+ N + V + S + G P V C
Sbjct: 134 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP-AVMECQ 192
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 205
+P T+SW DG PL ++ ++++ +LM+T R D
Sbjct: 193 PPRGHPEPTISWKKDGSPLDDKDERITIRG--------------GKLMITYTRKSDAGKY 238
Query: 206 FSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
+ R + V E LE V P AV + CE P
Sbjct: 239 VCVGTNMVGER---------ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 289
Query: 266 SPQIHWMKDGVPLP-----LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
P + W KD LP + L + ++ D G+Y+CVA + G E+ A ++++
Sbjct: 290 VPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA-ENMVGKAEASA-TLTV 347
Query: 321 IEP 323
EP
Sbjct: 348 QEP 350
Score = 51.6 bits (122), Expect = 1e-06
Identities = 57/254 (22%), Positives = 87/254 (34%), Gaps = 46/254 (18%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVAR--VLPNG 82
++ +GEP V++C+ P + WK + G P D + G
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWK--------------KDGSPLDDKDERITIRGG 223
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
L + D G + C N G+ + V + +P V S L V +
Sbjct: 224 KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE---RPSFVKRPSNLAVTVDDSAE 280
Query: 143 -TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C + G P T+ W D L + + R T L + GD
Sbjct: 281 FKCEARGD-PVPTVRWRKDDGELPKSRYEI-------RDDHT--------LKIRKVTAGD 324
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+++C + + A T +Q E VV+P VA G TVT CE
Sbjct: 325 -MGSYTCVAENMVGKAEASATLTVQ---------EPPHFVVKPRDQVVALGRTVTFQCEA 374
Query: 262 PAQPSPQIHWMKDG 275
P P I W ++G
Sbjct: 375 TGNPQPAIFWRREG 388
Score = 36.2 bits (82), Expect = 0.054
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 7/71 (9%)
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQ-------DQ 296
P VA GT L+C P P I W KDGV + S + L Q D
Sbjct: 461 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 520
Query: 297 GTYSCVATHSS 307
G Y+C+A+ S
Sbjct: 521 GRYTCIASTPS 531
Score = 33.9 bits (76), Expect = 0.27
Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL----PPSPVLILP----- 289
++V P V+ G TL C+ +P+P I W K G + P S ++LP
Sbjct: 69 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLF 128
Query: 290 -------EIGPQDQGTYSCVA 303
D+G Y CVA
Sbjct: 129 FLRIVHGRKSRPDEGVYVCVA 149
>gi|169214048 PREDICTED: hypothetical protein [Homo sapiens]
Length = 881
Score = 68.6 bits (166), Expect = 1e-11
Identities = 77/332 (23%), Positives = 122/332 (36%), Gaps = 39/332 (11%)
Query: 42 PKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLP-----------NGSLFLPAVG 90
P P + W+ + KVL+ G GP + + P G L L +
Sbjct: 217 PGPPTSLVVWRRGS------KVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQ 270
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 150
+ D G++ + + + + V VY+ + + A E G C+ G
Sbjct: 271 LDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP- 329
Query: 151 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 210
G LSW DG+ L E S +T R G L+V P R R ++C
Sbjct: 330 GRGELSWSRDGRAL---EAAESEGAETPRMRSEG----DQLLIVRPVRSDHAR--YTCRV 380
Query: 211 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGA-----VAPGGTVTLTCEVPAQP 265
A + + P P + V + A V G VTL C ++P
Sbjct: 381 RSPFGHREAAADVSV---FYGPDP---PTITVSSDRDAAPARFVTAGSNVTLRCAAASRP 434
Query: 266 SPQIHW-MKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPG 324
I W + D +P L+LP +GP GTY+C+A + G + +++++ +
Sbjct: 435 PADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
Query: 325 EEGPTAGSVGGSGLGTLALALGILGGLGTAAL 356
P GG G +L GG A+L
Sbjct: 495 PGAPQCSVEGGPGDRSLRFRCSWPGGAPAASL 526
>gi|89057602 PREDICTED: hypothetical protein [Homo sapiens]
Length = 881
Score = 68.6 bits (166), Expect = 1e-11
Identities = 77/332 (23%), Positives = 122/332 (36%), Gaps = 39/332 (11%)
Query: 42 PKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLP-----------NGSLFLPAVG 90
P P + W+ + KVL+ G GP + + P G L L +
Sbjct: 217 PGPPTSLVVWRRGS------KVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQ 270
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 150
+ D G++ + + + + V VY+ + + A E G C+ G
Sbjct: 271 LDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP- 329
Query: 151 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 210
G LSW DG+ L E S +T R G L+V P R R ++C
Sbjct: 330 GRGELSWSRDGRAL---EAAESEGAETPRMRSEG----DQLLIVRPVRSDHAR--YTCRV 380
Query: 211 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGA-----VAPGGTVTLTCEVPAQP 265
A + + P P + V + A V G VTL C ++P
Sbjct: 381 RSPFGHREAAADVSV---FYGPDP---PTITVSSDRDAAPARFVTAGSNVTLRCAAASRP 434
Query: 266 SPQIHW-MKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPG 324
I W + D +P L+LP +GP GTY+C+A + G + +++++ +
Sbjct: 435 PADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
Query: 325 EEGPTAGSVGGSGLGTLALALGILGGLGTAAL 356
P GG G +L GG A+L
Sbjct: 495 PGAPQCSVEGGPGDRSLRFRCSWPGGAPAASL 526
>gi|37551995 PREDICTED: hypothetical protein [Homo sapiens]
Length = 867
Score = 68.6 bits (166), Expect = 1e-11
Identities = 77/332 (23%), Positives = 122/332 (36%), Gaps = 39/332 (11%)
Query: 42 PKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLP-----------NGSLFLPAVG 90
P P + W+ + KVL+ G GP + + P G L L +
Sbjct: 217 PGPPTSLVVWRRGS------KVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQ 270
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 150
+ D G++ + + + + V VY+ + + A E G C+ G
Sbjct: 271 LDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP- 329
Query: 151 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 210
G LSW DG+ L E S +T R G L+V P R R ++C
Sbjct: 330 GRGELSWSRDGRAL---EAAESEGAETPRMRSEG----DQLLIVRPVRSDHAR--YTCRV 380
Query: 211 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGA-----VAPGGTVTLTCEVPAQP 265
A + + P P + V + A V G VTL C ++P
Sbjct: 381 RSPFGHREAAADVSV---FYGPDP---PTITVSSDRDAAPARFVTAGSNVTLRCAAASRP 434
Query: 266 SPQIHW-MKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPG 324
I W + D +P L+LP +GP GTY+C+A + G + +++++ +
Sbjct: 435 PADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
Query: 325 EEGPTAGSVGGSGLGTLALALGILGGLGTAAL 356
P GG G +L GG A+L
Sbjct: 495 PGAPQCSVEGGPGDRSLRFRCSWPGGAPAASL 526
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 66.6 bits (161), Expect = 4e-11
Identities = 81/293 (27%), Positives = 121/293 (41%), Gaps = 50/293 (17%)
Query: 20 VVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVL 79
+V A N+T GE VL C+ + P L W W+VL S RV
Sbjct: 403 LVPAPNVTVSPGETAVLSCR-VLGEAPYNLTW------VRDWRVLPA-------STGRVA 448
Query: 80 PNGSLFLPAVGI--QDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGV 137
L L GI D G ++C A N NG T+++ + V + P + I S+ + GV
Sbjct: 449 QLADLSLEISGIIPTDGGRYQCVASNANG-VTRASVWLLVREAP-QVSIHTSSQHFSQGV 506
Query: 138 PNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPET-GLFTLQSELMVTP 196
KV +C + G YP +SW + + L +E +R H + G +Q V P
Sbjct: 507 EVKV-SCSASG-YPTPHISWSRESQAL---------QEDSRIHVDAQGTLIIQG---VAP 552
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
G+ +SC + + + T +P + V VV VA G
Sbjct: 553 EDAGN----YSCQATNEVGTDQETVTL----YYTDPPSVSAVNAVV-----LVAVGEEAV 599
Query: 257 LTCEVPAQPSPQIHWMKDGVPLPLPP----SPVLILPEIGPQDQGTYSCVATH 305
L CE P P++ W + G+ + L P S L +P +D GTY+C A +
Sbjct: 600 LVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/320 (24%), Positives = 130/320 (40%), Gaps = 59/320 (18%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ +GE VL C+ A PP R+ W R +L+P+G +G L
Sbjct: 590 VLVAVGEEAVLVCE-ASGVPPPRVIWY----RGGLEMILAPEGSS----------SGKLR 634
Query: 86 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
+PA +D G + C+A+N G + + ++ V P ++ + ++T +
Sbjct: 635 IPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAP---QLTELPRDVTVELGRSALLAC 690
Query: 146 SEGSYPAGTLSWHL-DGKPLVPNEKGVSV---KEQTRRHPETGLFTLQSELMVTPARGGD 201
P T++W DG+PL G+ + + R P++G+ +S V P +
Sbjct: 691 RATGRPPPTVTWRRGDGQPL-----GLRLGAGRGSRSRQPDSGVLFFES---VAP----E 738
Query: 202 PRPTFSCS----FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTL 257
+ + C F R + T P++ P V G V+L
Sbjct: 739 DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRV-----------LEGQPVSL 787
Query: 258 TCEVPA-QPSPQIHWMKDGVPLP------LPPSPVLILPEIGPQDQGTYSCVATHSSHGP 310
C V A +P P+ HW+KDG PLP + L L + G YSCVAT+++
Sbjct: 788 PCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTA--G 845
Query: 311 QESRAVSISIIEPGEEGPTA 330
+ R V + + P PTA
Sbjct: 846 SQHRDVELVVQVPPRIHPTA 865
Score = 54.3 bits (129), Expect = 2e-07
Identities = 66/305 (21%), Positives = 114/305 (37%), Gaps = 42/305 (13%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 83
+++T +G +L C+ +PP + W+ G+ ++ + +G S +R +G
Sbjct: 676 RDVTVELGRSALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRG-----SRSRQPDSGV 729
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS--ELTAGVPNKV 141
LF +V +D+ + C+A N GK + P P+I SA + G P +
Sbjct: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--PQIASSAPTVRVLEGQPVSL 787
Query: 142 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C+ P W DG+PL P + S++ H + L +
Sbjct: 788 -PCIVLAGRPLPERHWLKDGRPLPPGSRH-SIRADGSLHLDRAL--------------QE 831
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+SC A TA Q R E V ++ G +L C
Sbjct: 832 HAGRYSCV---------ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVA 882
Query: 262 PAQPSPQIHWMKD-------GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESR 314
P+P I W K+ G + L++ + QD G Y C AT++ +
Sbjct: 883 SGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEM 942
Query: 315 AVSIS 319
+S++
Sbjct: 943 RLSVN 947
Score = 50.4 bits (119), Expect = 3e-06
Identities = 66/282 (23%), Positives = 101/282 (35%), Gaps = 39/282 (13%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVG 90
G+P+ L C +P W L GR P S + +GSL L
Sbjct: 782 GQPVSLPCIVLAGRPLPERHW-LKDGRPL-----------PPGSRHSIRADGSLHLDRAL 829
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 150
+ G + C A N G + + V Q+P + + GVP + CV+ G
Sbjct: 830 QEHAGRYSCVATNTAGSQHRDVELV--VQVPPRIHPTATHHITNEGVPASL-PCVASG-V 885
Query: 151 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 210
PA T++W + L T R P + + L+ P+ + +
Sbjct: 886 PAPTITWTKETNAL------------TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 933
Query: 211 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIH 270
+ G + +PR+ + + P G VTL CE P P +
Sbjct: 934 TVGFSSQEMRLSVNTKPRIH----MNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVT 989
Query: 271 WMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATH 305
W KD P+P L PS L L ++ D G Y C A++
Sbjct: 990 WTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASN 1031
Score = 43.9 bits (102), Expect = 3e-04
Identities = 63/298 (21%), Positives = 106/298 (35%), Gaps = 48/298 (16%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNG 82
A I + +PL++ C P RL+ + R + G W+ +
Sbjct: 316 APRIHGYLHQPLLVSCS-VHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR------ 368
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
+EG + C A++R G + ++ P++V + + + V
Sbjct: 369 ------ASKAEEGTYECTAVSRAGT---GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVL 419
Query: 143 TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM-VTPARGGD 201
+C G P L+W D + L + V+ L L E+ + P GG
Sbjct: 420 SCRVLGEAPYN-LTWVRDWRVLPASTGRVAQ-----------LADLSLEISGIIPTDGG- 466
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+ C S RA VW V E Q+ + + G V ++C
Sbjct: 467 ---RYQCVASNANGVTRA--------SVWLLVR-EAPQVSIHTSSQHFSQGVEVKVSCSA 514
Query: 262 PAQPSPQIHWMKDGVPLP------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
P+P I W ++ L + LI+ + P+D G YSC AT+ QE+
Sbjct: 515 SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET 572
Score = 40.0 bits (92), Expect = 0.004
Identities = 40/167 (23%), Positives = 65/167 (38%), Gaps = 40/167 (23%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+TA+ GE + L C+ A PP + W ++ P + +LP+GSL
Sbjct: 966 VTAKAGEEVTLDCE-AKGSPPPLVTWTKDSRPVP-----------PITNRYGLLPSGSLR 1013
Query: 86 LPAVGIQDEGIFRCQAMNRNGK---------ETKSNYRVRVYQIPGKPEIVDSAS----- 131
L V + D G + C A N G + +++++ + +P P + S
Sbjct: 1014 LAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQ 1073
Query: 132 -----------ELTAGVPNKVGT---CVSEGSYPAGTLSWHLDGKPL 164
L A +P T C+S+ + TLS HL PL
Sbjct: 1074 PTPRSVRLCHLSLRAPLPPPFATPTSCLSQACLSSSTLSLHLSPYPL 1120
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 66.6 bits (161), Expect = 4e-11
Identities = 81/293 (27%), Positives = 121/293 (41%), Gaps = 50/293 (17%)
Query: 20 VVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVL 79
+V A N+T GE VL C+ + P L W W+VL G RV
Sbjct: 519 LVPAPNVTVSPGETAVLSCR-VLGEAPYNLTW------VRDWRVLPASTG-------RVA 564
Query: 80 PNGSLFLPAVGI--QDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGV 137
L L GI D G ++C A N NG T+++ + V + P + I S+ + GV
Sbjct: 565 QLADLSLEISGIIPTDGGRYQCVASNANGV-TRASVWLLVREAP-QVSIHTSSQHFSQGV 622
Query: 138 PNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPET-GLFTLQSELMVTP 196
KV +C + G YP +SW + + L +E +R H + G +Q V P
Sbjct: 623 EVKV-SCSASG-YPTPHISWSRESQAL---------QEDSRIHVDAQGTLIIQG---VAP 668
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
G+ +SC + + + T +P + V VV VA G
Sbjct: 669 EDAGN----YSCQATNEVGTDQETVTLYYT----DPPSVSAVNAVV-----LVAVGEEAV 715
Query: 257 LTCEVPAQPSPQIHWMKDGVPLPLPP----SPVLILPEIGPQDQGTYSCVATH 305
L CE P P++ W + G+ + L P S L +P +D GTY+C A +
Sbjct: 716 LVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 768
Score = 43.9 bits (102), Expect = 3e-04
Identities = 63/298 (21%), Positives = 106/298 (35%), Gaps = 48/298 (16%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNG 82
A I + +PL++ C P RL+ + R + G W+ +
Sbjct: 432 APRIHGYLHQPLLVSCS-VHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR------ 484
Query: 83 SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG 142
+EG + C A++R G + ++ P++V + + + V
Sbjct: 485 ------ASKAEEGTYECTAVSRAGT---GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVL 535
Query: 143 TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM-VTPARGGD 201
+C G P L+W D + L + V+ L L E+ + P GG
Sbjct: 536 SCRVLGEAPYN-LTWVRDWRVLPASTGRVAQ-----------LADLSLEISGIIPTDGG- 582
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+ C S RA VW V E Q+ + + G V ++C
Sbjct: 583 ---RYQCVASNANGVTRA--------SVWLLVR-EAPQVSIHTSSQHFSQGVEVKVSCSA 630
Query: 262 PAQPSPQIHWMKDGVPLP------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
P+P I W ++ L + LI+ + P+D G YSC AT+ QE+
Sbjct: 631 SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET 688
Score = 34.3 bits (77), Expect = 0.21
Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 15/81 (18%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+ +GE VL C+ A PP R+ W R +L+P+G +G L
Sbjct: 706 VLVAVGEEAVLVCE-ASGVPPPRVIWY----RGGLEMILAPEGSS----------SGKLR 750
Query: 86 LPAVGIQDEGIFRCQAMNRNG 106
+PA +D G + C+A+N G
Sbjct: 751 IPAAQERDAGTYTCRAVNELG 771
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 65.5 bits (158), Expect = 8e-11
Identities = 78/322 (24%), Positives = 133/322 (41%), Gaps = 58/322 (18%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVA--RVLPN 81
+++T + P L C+ A PP + W + G P +S R+LP
Sbjct: 2583 EDVTVILNSPTSLVCE-AYSYPPATITWF--------------KDGTPLESNRNIRILPG 2627
Query: 82 GSLFLPAVGIQDE--GIFRCQAMNRNGKETKSNYRVRVYQIP--GKPEIVD---SASELT 134
G L + Q++ G + C A N G+ K +Y V+VY P K ++ S E+
Sbjct: 2628 GRT-LQILNAQEDNAGRYSCVATNEAGEMIK-HYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 135 AGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNE------KGVSVKEQTRRHPETGLFTL 188
V N + + P+ +LSW+ DG+PL ++ G +++ + + +TG +T
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTC 2745
Query: 189 QSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGA 248
V G+ F + ++ P ++WE + + E
Sbjct: 2746 -----VASNIAGEDELDFDVN----------IQVPPSFQKLWEIGNMLDTGR--NGEAKD 2788
Query: 249 VAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSC 301
V ++L CE A P P + W KDG PL LP VL +P +D G Y+C
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTC 2848
Query: 302 VATHSSHGPQESRAVSISIIEP 323
VA + + ++S + ++ P
Sbjct: 2849 VAVNEA--GEDSLQYDVRVLVP 2868
Score = 62.4 bits (150), Expect = 7e-10
Identities = 73/291 (25%), Positives = 110/291 (37%), Gaps = 43/291 (14%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 83
QN++ I + + L C+ + PP L W L G K P S++
Sbjct: 2111 QNVSVLISQAVELLCQ-SDAIPPPTLTW-LKDGHPLLKK--------PGLSISE--NRSV 2158
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT 143
L + +QD G + C+A N GK T+ NY V ++ +P D ++LT N +
Sbjct: 2159 LKIEDAQVQDTGRYTCEATNVAGK-TEKNYNVNIW-VPPNIGGSDELTQLTVIEGNLISL 2216
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPR 203
P L W G P++ + G + + +L ++ A D
Sbjct: 2217 LCESSGIPPPNLIWKKKGSPVLTDSMG-----------RVRILSGGRQLQISIAEKSDAA 2265
Query: 204 PTFSCSFS--PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+SC S G + I+P + P V G +++L CEV
Sbjct: 2266 -LYSCVASNVAGTAKKEYNLQVYIRPTITNSGS--------HPTEIIVTRGKSISLECEV 2316
Query: 262 PAQPSPQIHWMKDGVPL-------PLPPSPVLILPEIGPQDQGTYSCVATH 305
P P + WMKDG PL L +L L I D G Y CVA +
Sbjct: 2317 QGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVN 2367
Score = 61.2 bits (147), Expect = 2e-09
Identities = 74/301 (24%), Positives = 122/301 (40%), Gaps = 45/301 (14%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSL 84
N T + P+ L+CK A P +K N ++LS + + +++
Sbjct: 1929 NETVLVSNPVQLECKAAGNPVPVITWYKDN-------RLLSGSTSMTFLNRGQIID---- 1977
Query: 85 FLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTC 144
+ + I D GI++C A+N G T+ Y ++V+ P I S + + V N V
Sbjct: 1978 -IESAQISDAGIYKCVAINSAGA-TELFYSLQVHVAPS---ISGSNNMVAVVVNNPVRLE 2032
Query: 145 VSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRP 204
PA +L+W DG P+ G+ V R L +T A+ D
Sbjct: 2033 CEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI------------LALTSAQISDTGR 2080
Query: 205 TFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQ 264
+ + + R I RV+ P ++ E + +V V L C+ A
Sbjct: 2081 YTCVAVNAAGEKQR-----DIDLRVYVPP-----NIMGEEQNVSVLISQAVELLCQSDAI 2130
Query: 265 PSPQIHWMKDGVPLPLPPS-------PVLILPEIGPQDQGTYSCVATHSSHGPQESRAVS 317
P P + W+KDG PL P VL + + QD G Y+C AT+ + +++ V+
Sbjct: 2131 PPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVN 2190
Query: 318 I 318
I
Sbjct: 2191 I 2191
Score = 59.3 bits (142), Expect = 6e-09
Identities = 74/302 (24%), Positives = 121/302 (40%), Gaps = 49/302 (16%)
Query: 30 IGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV 89
I P+ L C+ PP +K T + KVL GG RVL +P
Sbjct: 2791 INNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG-------RVLQ-----IPRA 2838
Query: 90 GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGT--CVS 146
++D G + C A+N G+++ Y VRV P K D E+T V NK C+S
Sbjct: 2839 KVEDAGRYTCVAVNEAGEDSLQ-YDVRVLVPPIIKGANSDLPEEVTVLV-NKSALIECLS 2896
Query: 147 EGSYPAGTLSWHLDGKPLVPNEKGVSVKE-QTRRHPETGLFTLQSELMVTPARGGDPRPT 205
GS PA SW DG+PL+ ++ + + + T + + + V G +
Sbjct: 2897 SGS-PAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKY 2955
Query: 206 FSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
F+ + + P V P + E V ++LTCEV P
Sbjct: 2956 FNLN-------------VHVPPSVIGP----------KSENLTVVVNNFISLTCEVSGFP 2992
Query: 266 SPQIHWMKDGVPLPL-------PPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSI 318
P + W+K+ P+ L P L + D G Y+C+A + + ++ ++++
Sbjct: 2993 PPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052
Query: 319 SI 320
+
Sbjct: 3053 YV 3054
Score = 58.9 bits (141), Expect = 8e-09
Identities = 62/306 (20%), Positives = 119/306 (38%), Gaps = 44/306 (14%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNG 82
A+ + + + ++C+ PPQ + W N P S R+L G
Sbjct: 3349 AEKLMTLVDTSINIECRATGTPPPQ-INWLKNGLPL------------PLSSHIRLLAAG 3395
Query: 83 SLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKV 141
+ + + D ++ C A NR G + K +Y ++V+ P + + +
Sbjct: 3396 QVIRIVRAQVSDVAVYTCVASNRAGVDNK-HYNLQVFAPPNMDNSMGTEEITVLKGSSTS 3454
Query: 142 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
C+++G+ PA +++W DG+PL G+ H + +L+
Sbjct: 3455 MACITDGT-PAPSMAWLRDGQPL-----GLDA------HLTVSTHGMVLQLLKAETEDSG 3502
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
+ + + + +H L+ P + EE+ ++V + LTC
Sbjct: 3503 KYTCIASNEAGEVSKHFILKVLE-PPHINGSEEHEEISVIVN---------NPLELTCIA 3552
Query: 262 PAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESR 314
P+P++ WMKDG PLP L VL + +D G Y+C+A+ + +
Sbjct: 3553 SGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEY 3612
Query: 315 AVSISI 320
V + +
Sbjct: 3613 LVRVHV 3618
Score = 57.0 bits (136), Expect = 3e-08
Identities = 64/262 (24%), Positives = 98/262 (37%), Gaps = 37/262 (14%)
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT 143
L L + + D G + C A+N G T Y + V+ P S ++ N V
Sbjct: 2348 LQLKNIHVSDTGRYVCVAVNVAGM-TDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSL 2406
Query: 144 CVSEGSYPAGTLSWHLDGKPL-VPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 202
P +++W DG P+ + N + + R +T + V G+
Sbjct: 2407 TCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEE 2466
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
R F S + P + LE+V+ V +VTLTCEV
Sbjct: 2467 RKIFGLSVL-------------VPPHIVGENTLEDVK---------VKEKQSVTLTCEVT 2504
Query: 263 AQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRA 315
P P+I W KDG PL + L + + G Y+C+A SS +SR+
Sbjct: 2505 GNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLA--SSPAGHKSRS 2562
Query: 316 VSISIIEPGEEGPTAGSVGGSG 337
S+++ PT VG G
Sbjct: 2563 FSLNVF----VSPTIAGVGSDG 2580
Score = 55.5 bits (132), Expect = 9e-08
Identities = 66/296 (22%), Positives = 106/296 (35%), Gaps = 55/296 (18%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS-L 84
I I P+ L C A PP + W N R E L R+L GS L
Sbjct: 3161 IVETISNPVTLTCD-ATGIPPPTIAWLKNHKRIENSDSLE----------VRILSGGSKL 3209
Query: 85 FLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTC 144
+ D G + C A N GK K Y Q+P + S+++ + V
Sbjct: 3210 QIARSQHSDSGNYTCIASNMEGKAQK--YYFLSIQVPPSVAGAEIPSDVSVLLGENVELV 3267
Query: 145 VSEGSYPAGTLSWHLDGKPLVPNE--------KGVSVKEQTRRHPETGLFTLQSELMVTP 196
+ P + W DGKP+ E G ++ +TG +T + P
Sbjct: 3268 CNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTC---VATNP 3324
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
A D + +P + ++ E++ +V+ ++
Sbjct: 3325 AGEEDRIFNLNVYVTPTIRGNKD--------------EAEKLMTLVDT---------SIN 3361
Query: 257 LTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATH 305
+ C P PQI+W+K+G+PLP L V+ + D Y+CVA++
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Score = 52.8 bits (125), Expect = 6e-07
Identities = 63/243 (25%), Positives = 92/243 (37%), Gaps = 36/243 (14%)
Query: 77 RVLPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA 135
R+L G + L ++D G + C N G+E K + + P IV +
Sbjct: 2434 RILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK----IFGLSVLVPPHIVGENTLEDV 2489
Query: 136 GVPNKVG---TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSEL 192
V K TC G+ P ++WH DG+PL +E H +G LQ
Sbjct: 2490 KVKEKQSVTLTCEVTGN-PVPEITWHKDGQPL---------QEDEAHHIISGGRFLQITN 2539
Query: 193 MVTPARGGDPRPTFSC-SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP 251
+ P G ++C + SP + R+ V+ + V PE V
Sbjct: 2540 VQVPHTG-----RYTCLASSPAGHKSRSFSL-----NVFVSPTIAGVGSDGNPEDVTVIL 2589
Query: 252 GGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVAT 304
+L CE + P I W KDG PL LP L + + G YSCVAT
Sbjct: 2590 NSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVAT 2649
Query: 305 HSS 307
+ +
Sbjct: 2650 NEA 2652
Score = 51.6 bits (122), Expect = 1e-06
Identities = 78/330 (23%), Positives = 129/330 (39%), Gaps = 46/330 (13%)
Query: 11 VLVLSLWGAVVGAQNITARI--GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQG 68
V V L ++G A + G+ L L C P W N+ A + +P
Sbjct: 882 VTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNS----AMLLQNPY- 936
Query: 69 GGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVD 128
V +GSL + V +QD G + C A N G K+ V V+ +P
Sbjct: 937 -------ITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTT-SVVVHVLPTIQHGQQ 988
Query: 129 SASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTL 188
S + G+P + C + G+ P ++ W G+ + + S
Sbjct: 989 ILSTIE-GIPVTL-PCKASGN-PKPSVIWSKKGELISTSSAKFSAGADG----------- 1034
Query: 189 QSELMVTPARGGDPRPTFSCSFS--PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEG 246
S +V+P GG+ + C+ + G + + T ++PRV+ + +P
Sbjct: 1035 -SLYVVSP--GGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGD---QRGLSQDKPVE 1088
Query: 247 GAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLP--------PSPVLILPEIGPQDQGT 298
+V G VTL CEV + P P I W K+ L P PS + + E D G
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKE-TQLISPFSPRHTFLPSGSMKITETRTSDSGM 1147
Query: 299 YSCVATHSSHGPQESRAVSISIIEPGEEGP 328
Y CVAT+ + ++ +++ + + GP
Sbjct: 1148 YLCVATNIAGNVTQAVKLNVHVPPKIQRGP 1177
Score = 51.6 bits (122), Expect = 1e-06
Identities = 75/333 (22%), Positives = 129/333 (38%), Gaps = 50/333 (15%)
Query: 4 GTAVGAWVLVLSLWGAVVGAQ---NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
G A + L + + +V GA+ +++ +GE + L C A P ++W L G+
Sbjct: 3231 GKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCN-ANGIPTPLIQW-LKDGK--- 3285
Query: 61 WKVLSPQGGGPWDSVARVLPNGS-LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQ 119
P G + + RV NGS L + D G + C A N G+E + + + VY
Sbjct: 3286 -----PIASGETERI-RVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRI-FNLNVYV 3338
Query: 120 IPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPL-VPNEKGVSVKEQTR 178
P D A +L V + P ++W +G PL + + + Q
Sbjct: 3339 TPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVI 3398
Query: 179 RHPETGLFTLQSELMVTPARGGDPRPTFSCS-FSPGLPRHRALRTAPIQPRVWEPVPLEE 237
R + + V R G ++ F+P P + + EE
Sbjct: 3399 RIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAP--------------PNMDNSMGTEE 3444
Query: 238 VQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPP-------SPVLILPE 290
+ V G + ++ C P+P + W++DG PL L VL L +
Sbjct: 3445 I---------TVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLK 3495
Query: 291 IGPQDQGTYSCVATHSSHGPQESRAVSISIIEP 323
+D G Y+C+A S+ + S+ + ++EP
Sbjct: 3496 AETEDSGKYTCIA--SNEAGEVSKHFILKVLEP 3526
Score = 51.6 bits (122), Expect = 1e-06
Identities = 68/310 (21%), Positives = 124/310 (40%), Gaps = 48/310 (15%)
Query: 22 GAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPN 81
G Q++ + + VL+C A P R+ W+ + VL+ + +L N
Sbjct: 3718 GPQSLVILLNKSTVLECI-AEGVPTPRITWRKDGA------VLAGN-----HARYSILEN 3765
Query: 82 GSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKV 141
G L + + + D G + C A N G + + R+ + Q+ P I + +T V +
Sbjct: 3766 GFLHIQSAHVTDTGRYLCMATNAAGTDRR---RIDL-QVHVPPSIAPGPTNMTVIVNVQT 3821
Query: 142 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
P +++W +G L ++ S + L + S ++++P+ D
Sbjct: 3822 TLACEATGIPKPSINWRKNGHLLNVDQNQNSYR----------LLSSGSLVIISPSV--D 3869
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
T+ C+ + G + RT + +V + E +V AV +TC
Sbjct: 3870 DTATYECTVTNGAGDDK--RTVDLTVQVPPSIADEPTDFLVTKHAPAV-------ITCTA 3920
Query: 262 PAQPSPQIHWMKDGVPLPLP--------PSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
P P IHW K+G+ L LP S + + G Y+CVA +++
Sbjct: 3921 SGVPFPSIHWTKNGIRL-LPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAH-- 3977
Query: 314 RAVSISIIEP 323
R V++ + EP
Sbjct: 3978 RHVTLHVHEP 3987
Score = 50.4 bits (119), Expect = 3e-06
Identities = 53/245 (21%), Positives = 99/245 (40%), Gaps = 36/245 (14%)
Query: 93 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 152
D+G ++C N GK+ K + ++ +Y IP + + ++++ + + + P
Sbjct: 1519 DKGRYQCTVSNAAGKQAK-DIKLTIY-IPPSIKGGNVTTDISVLINSLIKLECETRGLPM 1576
Query: 153 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSP 212
++W+ DG+P++ + + + + + H P T++C +
Sbjct: 1577 PAITWYKDGQPIMSSSQALYIDKGQYLH--------------IPRAQVSDSATYTCHVA- 1621
Query: 213 GLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM 272
TA V VP + P V ++TL C+ PSP + W+
Sbjct: 1622 -----NVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWL 1676
Query: 273 KDGVPLPLPPS----------PVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIE 322
KDGVP+ + ++ EI D+G Y CVAT S G +E + ++
Sbjct: 1677 KDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT-SVAGEKEIKYEVDVLVP 1732
Query: 323 PGEEG 327
P EG
Sbjct: 1733 PAIEG 1737
Score = 49.7 bits (117), Expect = 5e-06
Identities = 58/251 (23%), Positives = 94/251 (37%), Gaps = 39/251 (15%)
Query: 78 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGV 137
VLP+G L + +D G + C A N G ++ V Q+P P I E V
Sbjct: 4037 VLPSGGLQISRAVREDAGTYMCVAQNPAGTAL-GKIKLNV-QVP--PVISPHLKEYVIAV 4092
Query: 138 PNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPA 197
+ P ++WH DG+ +V S++++ L +
Sbjct: 4093 DKPITLSCEADGLPPPDITWHKDGRAIVE-----SIRQRVLS---------SGSLQIAFV 4138
Query: 198 RGGDP-RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
+ GD T + G T + PR+ E V A+ P
Sbjct: 4139 QPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRST----EGHYTVNENSQAILP----- 4189
Query: 257 LTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSSHG 309
C P+P I+W KD V L P LIL + +D G Y+CVA +++
Sbjct: 4190 --CVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAA-- 4245
Query: 310 PQESRAVSISI 320
+++ VS+++
Sbjct: 4246 GEDTHTVSLTV 4256
Score = 49.3 bits (116), Expect = 6e-06
Identities = 69/295 (23%), Positives = 110/295 (37%), Gaps = 47/295 (15%)
Query: 33 PLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQ 92
P V+ C A P + W N R L P+G G R+L +G++ + A +
Sbjct: 3913 PAVITCT-ASGVPFPSIHWTKNGIR------LLPRGDG-----YRILSSGAIEILATQLN 3960
Query: 93 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPA 152
G + C A N G S +R + P I SEL + N + P+
Sbjct: 3961 HAGRYTCVARNAAG----SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPS 4016
Query: 153 GTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC-SFS 211
++W ++G++V R H LQ V G T+ C + +
Sbjct: 4017 PFITWQ---------KEGINVNTSGRNHAVLPSGGLQISRAVREDAG-----TYMCVAQN 4062
Query: 212 PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHW 271
P ++ P V P E V V +P +TL+CE P P I W
Sbjct: 4063 PAGTALGKIKLNVQVPPVISPHLKEYVIAVDKP----------ITLSCEADGLPPPDITW 4112
Query: 272 MKDG------VPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
KDG + + S L + + P D G Y+C+A + + S +++ +
Sbjct: 4113 HKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHV 4167
Score = 48.1 bits (113), Expect = 1e-05
Identities = 65/291 (22%), Positives = 107/291 (36%), Gaps = 44/291 (15%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
I+ GE + L C+ PP + W T Q P+ LP+GS+
Sbjct: 1089 ISVLAGEEVTLPCE-VKSLPPPIITWAKET-----------QLISPFSPRHTFLPSGSMK 1136
Query: 86 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
+ D G++ C A N G T++ ++ V+ +P P+I L V +V
Sbjct: 1137 ITETRTSDSGMYLCVATNIAGNVTQA-VKLNVH-VP--PKIQRGPKHLKVQVGQRVDIPC 1192
Query: 146 SEGSYPAGTLSWHLDGKP-LVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRP 204
+ P ++W G LV E VS +P+ L Q+ TP+ G
Sbjct: 1193 NAQGTPLPVITWSKGGSTMLVDGEHHVS-------NPDGTLSIDQA----TPSDAG---- 1237
Query: 205 TFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQ 264
++C + T +Q EP +E+++ + C
Sbjct: 1238 IYTCVATNIAGTDETEITLHVQ----EPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGT 1293
Query: 265 PSPQIHWMKDGVPLP--------LPPSPVLILPEIGPQDQGTYSCVATHSS 307
P P I W+ +G L L +L++ + P D G Y CVA + +
Sbjct: 1294 PKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEA 1344
Score = 48.1 bits (113), Expect = 1e-05
Identities = 74/319 (23%), Positives = 123/319 (38%), Gaps = 56/319 (17%)
Query: 2 AAGTAVGAWVLVLSLWGAVVGAQNITARI-GEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
+AG + L + + ++ G+ N+ A + P+ L+C+ A P L W
Sbjct: 1996 SAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECE-ARGIPAPSLTWL-------- 2046
Query: 61 WKVLSPQGGGPWDSVA---RVLPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVR 116
+ G P S + +VL G + L + I D G + C A+N G E + + +R
Sbjct: 2047 ------KDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAG-EKQRDIDLR 2099
Query: 117 VYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQ 176
VY +P P I+ ++ + V + P TL+W DG PL+ + G+S+ E
Sbjct: 2100 VY-VP--PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLL-KKPGLSISEN 2155
Query: 177 TRRHPETGLFTLQSELMVTPARGGDP-RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPL 235
+S L + A+ D R T + G + P + L
Sbjct: 2156 ------------RSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDEL 2203
Query: 236 EEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQ- 294
++ V G ++L CE P P + W K G P+ + + G Q
Sbjct: 2204 TQL---------TVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQL 2254
Query: 295 --------DQGTYSCVATH 305
D YSCVA++
Sbjct: 2255 QISIAEKSDAALYSCVASN 2273
Score = 47.4 bits (111), Expect = 2e-05
Identities = 58/240 (24%), Positives = 88/240 (36%), Gaps = 44/240 (18%)
Query: 80 PNGSLFLPAVGIQDEGIFRCQAMNRNGK-ETKSNYRVRVYQIPGKPEIVDSASELTAGVP 138
P+G+L + D GI+ C A N G ET+ V+ P + D
Sbjct: 1222 PDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE-----PPTVEDLEPPYNTTFQ 1276
Query: 139 NKVGT------CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSEL 192
+V C ++G+ P T+ W +G+ L E G+S+ E TL
Sbjct: 1277 ERVANQRIEFPCPAKGT-PKPTIKWLHNGRELTGREPGISILEDG---------TLLVIA 1326
Query: 193 MVTPARGGDPRPTFSCSF--SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVA 250
VTP G+ + C G + + P + + + V +++
Sbjct: 1327 SVTPYDNGE----YICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQ------ 1376
Query: 251 PGGTVTLTCEVPAQPSPQIHWMKDGVPL-------PLPPSPVLILPEIGPQDQGTYSCVA 303
L CEV PSP I W KD V + + +L L P+D G YSC A
Sbjct: 1377 ---LTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKA 1433
Score = 47.4 bits (111), Expect = 2e-05
Identities = 64/258 (24%), Positives = 100/258 (38%), Gaps = 40/258 (15%)
Query: 78 VLPNGSLFLPA-VGIQDEGIFRCQAMNRNGK-ETKSNYRVRVYQIPGKPEIVDSASELTA 135
+L +G+L + A V D G + C A+N G E K N +V V + E V + S L
Sbjct: 1316 ILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLN 1375
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
+ N C EG+ P+ + W+ D + + +V + T
Sbjct: 1376 QLTNLF--CEVEGT-PSPIIMWYKDNVQVTESSTIQTVNNGK----------ILKLFRAT 1422
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVE--PEGGAVAPGG 253
P G +SC +A+ A + + L ++ P +V
Sbjct: 1423 PEDAG----RYSC---------KAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNR 1469
Query: 254 TVTLTCEVPAQPSPQIHWMKDGVPL--------PLPPSPVLILPEIGPQDQGTYSCVATH 305
V L C+V P P IHW KDG PL L VL L D+G Y C T
Sbjct: 1470 DVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQC--TV 1527
Query: 306 SSHGPQESRAVSISIIEP 323
S+ ++++ + ++I P
Sbjct: 1528 SNAAGKQAKDIKLTIYIP 1545
Score = 45.1 bits (105), Expect = 1e-04
Identities = 73/340 (21%), Positives = 135/340 (39%), Gaps = 67/340 (19%)
Query: 3 AGTAVGAWVLVLSLWGAVVG--AQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA 60
AG+A + L + + +V+G ++N+T + + L C+ + PP L W N +
Sbjct: 2949 AGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPD-LSWLKNEQPIKL 3007
Query: 61 WKVLSPQGGGPWDSVARVLPNG-SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQ 119
++ ++P G +L + + D G + C A+N+ G E+K + + VY
Sbjct: 3008 ------------NTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAG-ESKKKFSLTVY- 3053
Query: 120 IPGKPEIVDSASELTAGVPNKVGTCVS----EGSYPAGTLSWHLDGKPLVPNEKGVSVKE 175
+P P I D SE + V + GT VS + P ++W+ +G+ + + + +
Sbjct: 3054 VP--PSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILAD 3111
Query: 176 QTRRH------PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRV 229
H +TG + ++ G D + + P P +
Sbjct: 3112 GQMLHIKKAEVSDTGQYVCRA----INVAGRDDKNFHLNVYVP--------------PSI 3153
Query: 230 WEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP---------L 280
P E +++VE VTLTC+ P P I W+K+ + L
Sbjct: 3154 EGP----EREVIVE------TISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRIL 3203
Query: 281 PPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
L + D G Y+C+A++ Q+ +SI +
Sbjct: 3204 SGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQV 3243
Score = 45.1 bits (105), Expect = 1e-04
Identities = 61/263 (23%), Positives = 105/263 (39%), Gaps = 39/263 (14%)
Query: 80 PNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPN 139
P G L L V ++D G + C A N G++T + + V+ +P E+ S L G
Sbjct: 4220 PYGELILENVVLEDSGFYTCVANNAAGEDTHT-VSLTVHVLPTFTELPGDVS-LNKGEQL 4277
Query: 140 KVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARG 199
++ +C + G P L+W + + + V+ SEL++
Sbjct: 4278 RL-SCKATG-IPLPKLTWTFNNNIIPAHFDSVNG---------------HSELVIERVSK 4320
Query: 200 GDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTC 259
D T+ C+ + +A+ ++ EP + P GG L C
Sbjct: 4321 EDSG-TYVCTAENSVGFVKAIGFVYVK----EPPVFKGDY----PSNWIEPLGGNAILNC 4371
Query: 260 EVPAQPSPQIHWMKDGVPLPLP------PSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
EV P+P I W + GV + + + L + +D G Y+CVAT+ + + S
Sbjct: 4372 EVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERS 4431
Query: 314 RAVS-----ISIIEPGEEGPTAG 331
+++ I +EP E AG
Sbjct: 4432 MSLTLQSPPIITLEPVETVINAG 4454
Score = 44.3 bits (103), Expect = 2e-04
Identities = 69/340 (20%), Positives = 123/340 (36%), Gaps = 64/340 (18%)
Query: 16 LWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSV 75
LWG + + + ++ L L+C+ A P L W + ++ D
Sbjct: 2674 LWGPGLSPKEVKIKVNNTLTLECE-AYAIPSASLSWYKDGQPLKS------------DDH 2720
Query: 76 ARVLPNG-SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELT 134
+ NG +L + I D G + C A N G E + ++ V + P ++ + + L
Sbjct: 2721 VNIAANGHTLQIKEAQISDTGRYTCVASNIAG-EDELDFDVNIQVPPSFQKLWEIGNMLD 2779
Query: 135 AG---------VPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGL 185
G + N + + P TL+W+ DG PL ++K L
Sbjct: 2780 TGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDK--------------VL 2825
Query: 186 FTLQSELMVTPARGGDPRPTFSC-----SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL 240
++ P + ++C + L + PI +P EEV +
Sbjct: 2826 ILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLP-EEVTV 2884
Query: 241 VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGP 293
+V + + C P+P+ W KDG PL L +L +
Sbjct: 2885 LVNK---------SALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQI 2935
Query: 294 QDQGTYSCVATHSSHGPQESRAVSI----SIIEPGEEGPT 329
D G Y CVA +++ ++ +++ S+I P E T
Sbjct: 2936 TDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLT 2975
Score = 43.9 bits (102), Expect = 3e-04
Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 52/232 (22%)
Query: 92 QDEGIFRCQAMNRNGKETKSNYRVRVYQIP---GKPEIVDSASELTAGVPNKVG-TCVSE 147
+D G + C A N G+ +K ++ ++V + P G E E++ V N + TC++
Sbjct: 3499 EDSGKYTCIASNEAGEVSK-HFILKVLEPPHINGSEE----HEEISVIVNNPLELTCIAS 3553
Query: 148 GSYPAGTLSWHLDGKPLVPNEK------GVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
G PA ++W DG+PL ++ G ++ T + +TG +T L +PA D
Sbjct: 3554 G-IPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTC---LASSPAGDDD 3609
Query: 202 PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEV 261
P + EP V VTL C+
Sbjct: 3610 KEYLVRVHVPPNIAG------------------------TDEPRDITVLRNRQVTLECKS 3645
Query: 262 PAQPSPQIHWMKDGVPLPLPPSPVLILP-----EIGPQDQG---TYSCVATH 305
A P P I W+++G L P V IL +I D G Y+CVA++
Sbjct: 3646 DAVPPPVITWLRNGERLQATPR-VRILSGGRYLQINNADLGDTANYTCVASN 3696
Score = 43.1 bits (100), Expect = 4e-04
Identities = 55/240 (22%), Positives = 85/240 (35%), Gaps = 39/240 (16%)
Query: 77 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAG 136
R L N SL L +V D G + C + G S + Q P K ++ T G
Sbjct: 569 RTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF--LTVQEPPKVTVMPKNQSFTGG 626
Query: 137 VPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTP 196
++V S YP ++W ++ +V + + R G +++ P
Sbjct: 627 --SEVSIMCSATGYPKPKIAWTVNDMFIVGSHR--------YRMTSDGTLFIKN---AAP 673
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
G + C S + T +E +L+V VA G
Sbjct: 674 KDAG----IYGCLASNSAGTDKQNSTLRY---------IEAPKLMVVQSELLVALGDITV 720
Query: 257 LTCEVPAQPSPQIHWMKDGVPLPLPPSPVLI---------LPEIGPQDQGTYSCVATHSS 307
+ C+ P PQ+ W K L L PS LI + E D G Y+CVA + +
Sbjct: 721 MECKTSGIPPPQVKWFKG--DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEA 778
Score = 42.7 bits (99), Expect = 6e-04
Identities = 63/255 (24%), Positives = 98/255 (38%), Gaps = 40/255 (15%)
Query: 77 RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAG 136
R+ +G+LF+ +D GI+ C A N G + K N +R + P +++ SEL
Sbjct: 659 RMTSDGTLFIKNAAPKDAGIYGCLASNSAGTD-KQNSTLRYIEAP---KLMVVQSELLVA 714
Query: 137 VPN-KVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
+ + V C + G P + W L P+ + P GL +Q
Sbjct: 715 LGDITVMECKTSG-IPPPQVKWFKGDLELRPSTFLII-------DPLLGLLKIQE---TQ 763
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTV 255
GD ++C R T I V P P+ + EP ++ G V
Sbjct: 764 DLDAGD----YTCVAINEAGR----ATGKITLDVGSP-PV----FIQEPADVSMEIGSNV 810
Query: 256 TLTCEVPAQPSPQIHWMK-DGVPLPLPPSPV----------LILPEIGPQDQGTYSCVAT 304
TL C V P P I W + D +P+ P V L + + D+GTY C A
Sbjct: 811 TLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAE 870
Query: 305 HSSHGPQESRAVSIS 319
+ Q V+++
Sbjct: 871 NQFGKIQSETTVTVT 885
Score = 41.2 bits (95), Expect = 0.002
Identities = 58/241 (24%), Positives = 93/241 (38%), Gaps = 35/241 (14%)
Query: 77 RVLPNG-SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTA 135
++L NG L + + + G++RC A N G + K + V V+ +P P I S
Sbjct: 1782 KILLNGRKLVIAQAQVSNTGLYRCMAANTAG-DHKKEFEVTVH-VP--PTIKSSGLSERV 1837
Query: 136 GVPNKVGT--CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM 193
V K C++ G P +++W D +P+ + + ++ R LQ
Sbjct: 1838 VVKYKPVALQCIANG-IPNPSITWLKDDQPVNTAQGNLKIQSSGR--------VLQIAKT 1888
Query: 194 VTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGG 253
+ G R T + + G + IQ V EP LE+ ++ V
Sbjct: 1889 LLEDAG---RYTCVATNAAGETQQH------IQLHVHEPPSLEDAGKMLNE---TVLVSN 1936
Query: 254 TVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHS 306
V L C+ P P I W KD L L ++ + D G Y CVA +S
Sbjct: 1937 PVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINS 1996
Query: 307 S 307
+
Sbjct: 1997 A 1997
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 14/91 (15%)
Query: 248 AVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP--------LPPSPVLILPEIGPQDQGTY 299
AV V L CE P+P + W+KDG P+ L +L L D G Y
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRY 2081
Query: 300 SCVATHSSHGPQESRAVSISIIEP----GEE 326
+CVA +++ ++ R + + + P GEE
Sbjct: 2082 TCVAVNAA--GEKQRDIDLRVYVPPNIMGEE 2110
Score = 39.7 bits (91), Expect = 0.005
Identities = 58/255 (22%), Positives = 96/255 (37%), Gaps = 48/255 (18%)
Query: 92 QDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT-------- 143
+D G + C+A+N G K + + V +P P I+ + PN+V
Sbjct: 1424 EDAGRYSCKAINIAGTSQKY-FNIDVL-VP--PTIIGT------NFPNEVSVVLNRDVAL 1473
Query: 144 -CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDP 202
C +G+ P + W DGKPL + P L L + AR D
Sbjct: 1474 ECQVKGT-PFPDIHWFKDGKPLFLGD------------PNVELLDRGQVLHLKNARRND- 1519
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
+ + C+ S + + I+ ++ P ++ + + +V + L CE
Sbjct: 1520 KGRYQCTVSNAAGK----QAKDIKLTIYIPPSIKGGNVTTDI---SVLINSLIKLECETR 1572
Query: 263 AQPSPQIHWMKDGVP-------LPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRA 315
P P I W KDG P L + L +P D TY+C + + ++S
Sbjct: 1573 GLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFH 1632
Query: 316 VSISIIEPGEEGPTA 330
V + + P EG A
Sbjct: 1633 VDV-YVPPMIEGNLA 1646
Score = 38.9 bits (89), Expect = 0.008
Identities = 65/267 (24%), Positives = 108/267 (40%), Gaps = 37/267 (13%)
Query: 73 DSVARVLPNGSLF-LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSAS 131
D + L NG + + I D G + C A N G K + + V+ +P P ++ S
Sbjct: 2916 DDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS-AKKYFNLNVH-VP--PSVIGPKS 2971
Query: 132 E-LTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQS 190
E LT V N + +P LSW + NE+ + + T P G TLQ
Sbjct: 2972 ENLTVVVNNFISLTCEVSGFPPPDLSW-------LKNEQPIKLNTNTLIVP--GGRTLQI 3022
Query: 191 ELMVTPARGGDPRPTFSCSF--SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGA 248
+ + GG+ ++C G + + T + P + + E + +V
Sbjct: 3023 -IRAKVSDGGE----YTCIAINQAGESKKKFSLTVYVPPSIKDH-DSESLSVV------N 3070
Query: 249 VAPGGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSC 301
V G +V+L CE A P P I W K+G + L +L + + D G Y C
Sbjct: 3071 VREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVC 3130
Query: 302 VATHSSHGPQESRAVSISIIEPGEEGP 328
A + + ++ +++ + P EGP
Sbjct: 3131 RAINVAGRDDKNFHLNV-YVPPSIEGP 3156
Score = 38.1 bits (87), Expect = 0.014
Identities = 72/337 (21%), Positives = 121/337 (35%), Gaps = 57/337 (16%)
Query: 3 AGTAVGAWVLVLSLWGAVVGAQNITARI-GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAW 61
AGT +V+ + + Q I + I G P+ L CK + P + K + E
Sbjct: 966 AGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSK----KGELI 1021
Query: 62 KVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIP 121
S + D GSL++ + G ++ G + C A N G K ++ VY
Sbjct: 1022 STSSAKFSAGAD--------GSLYVVSPGGEESGEYVCTATNTAGY-AKRKVQLTVYV-- 1070
Query: 122 GKPEIVDSASELTAGVPNKVGTCVSEG--------SYPAGTLSWHLDGKPLVPNEKGVSV 173
+P + L+ P ++ E S P ++W + + + P
Sbjct: 1071 -RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP---- 1125
Query: 174 KEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV 233
RH F + +T R D S + T ++ V P
Sbjct: 1126 -----RHT----FLPSGSMKITETRTSD-----SGMYLCVATNIAGNVTQAVKLNVHVPP 1171
Query: 234 PLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLP-------PSPVL 286
++ P+ V G V + C P P I W K G + + P L
Sbjct: 1172 KIQR-----GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTL 1226
Query: 287 ILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEP 323
+ + P D G Y+CVAT+ + G E+ +++ + EP
Sbjct: 1227 SIDQATPSDAGIYTCVATNIA-GTDETE-ITLHVQEP 1261
Score = 35.8 bits (81), Expect = 0.071
Identities = 65/286 (22%), Positives = 102/286 (35%), Gaps = 49/286 (17%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSL 84
+++ GE L L CK A P +L W N A +DSV + L
Sbjct: 4268 DVSLNKGEQLRLSCK-ATGIPLPKLTWTFNNNIIPAH----------FDSVNG---HSEL 4313
Query: 85 FLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-KPEIVDSASELTAGVPNKVGT 143
+ V +D G + C A N G + V V + P K + + E G N +
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGF-VYVKEPPVFKGDYPSNWIEPLGG--NAILN 4370
Query: 144 CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPR 203
C +G P T+ W N KGV + E + R + G +L V G
Sbjct: 4371 CEVKGD-PTPTIQW---------NRKGVDI-EISHRIRQLGNGSLAIYGTVNEDAGD--- 4416
Query: 204 PTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPA 263
++C A A + R + +EP + GG + L C+
Sbjct: 4417 --YTCV---------ATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATG 4465
Query: 264 QPSPQIHWMKDGVPLP------LPPSPVLILPEIGPQDQGTYSCVA 303
+P P I W + G + + + L + + +D + CVA
Sbjct: 4466 EPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVA 4511
Score = 35.0 bits (79), Expect = 0.12
Identities = 69/309 (22%), Positives = 107/309 (34%), Gaps = 60/309 (19%)
Query: 30 IGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV 89
I L L+CK A P L W + +A + + GG L + +
Sbjct: 1655 IAHSLTLECKAAGNPSPI-LTWLKDGVPVKANDNIRIEAGGK-----------KLEIMSA 1702
Query: 90 GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGS 149
D G + C A + G E + Y V V +P E D S V N +
Sbjct: 1703 QEIDRGQYICVATSVAG-EKEIKYEVDVL-VPPAIEGGDETSYFIVMVNNLLELDCHVTG 1760
Query: 150 YPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH-------PETGLFTLQSELMVTPARGGDP 202
P T+ W DG+ L+ G + R+ TGL+ + GD
Sbjct: 1761 SPPPTIMWLKDGQ-LIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAA-----NTAGDH 1814
Query: 203 RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP 262
+ F T + P + E V + +P V L C
Sbjct: 1815 KKEFEV-------------TVHVPPTIKSSGLSERVVVKYKP----------VALQCIAN 1851
Query: 263 AQPSPQIHWMKDGVPLPL--------PPSPVLILPEIGPQDQGTYSCVATHSSHGPQESR 314
P+P I W+KD P+ VL + + +D G Y+CVAT+++ Q+
Sbjct: 1852 GIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQH- 1910
Query: 315 AVSISIIEP 323
+ + + EP
Sbjct: 1911 -IQLHVHEP 1918
Score = 30.8 bits (68), Expect = 2.3
Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 15/103 (14%)
Query: 229 VWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL-PPSPV-- 285
V EP P+ +V P V PG LTC + + + W ++ + L P+ +
Sbjct: 516 VSEPPPVIQV-----PNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRT 570
Query: 286 -----LILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEP 323
L L + D G Y C+ SS G + +V +++ EP
Sbjct: 571 LANLSLELKSVKFNDAGEYHCMV--SSEGGSSAASVFLTVQEP 611
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 65.1 bits (157), Expect = 1e-10
Identities = 89/409 (21%), Positives = 159/409 (38%), Gaps = 63/409 (15%)
Query: 20 VVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVL 79
V+ Q++ E + C+ + + PP L+W E ++ + P A V
Sbjct: 228 VLAPQDVVVARYEEAMFHCQFSAQPPPS-LQWLF-----EDETPITNRSRPPHLRRATVF 281
Query: 80 PNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPN 139
NGSL L V ++ GI+RC + G + + +I P + TAG
Sbjct: 282 ANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--LFEPRVFTAGSEE 339
Query: 140 KVGTCVSEGSYPAGTLSWHLDGKPLVPN----EKGVSVKEQTRRHPETGLFTLQS----- 190
+V TC+ P ++ W G L + +KG + + G++T +
Sbjct: 340 RV-TCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAG 398
Query: 191 ----ELMVTPARGG--------------------DPRPTFSCSFSPGLPRHRALRTAPIQ 226
++ +T A G D ++C S G P+ + +
Sbjct: 399 QRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNG-PQGQIRAHVQLT 457
Query: 227 PRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWM-KDGV--PLPLPP- 282
V+ + VEPE V G T L CE P P I W KD + P L P
Sbjct: 458 VAVF-------ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR 510
Query: 283 -----SPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGG-S 336
+ L++ ++ P+D G Y+C+A +S + + + EE GS
Sbjct: 511 MHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK 570
Query: 337 GLGTLALALGILGGLGTAALLIGVILWQRRQRRGEE-RKAPENQEEEEE 384
+ T+ L++G + ++G++ + +++ + + +K PE +E E E
Sbjct: 571 MIQTIGLSVG--AAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEME 617
Score = 48.9 bits (115), Expect = 8e-06
Identities = 63/256 (24%), Positives = 97/256 (37%), Gaps = 38/256 (14%)
Query: 73 DSVARVLPNGSLFLPAVG-IQDEGIFRCQAMNR-NGKETKS-NYRVRVYQIPGKPEIVDS 129
D+ R SL AV +QD G F+C A + G+E +S N + I P ++
Sbjct: 74 DTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKH 133
Query: 130 -ASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTL 188
ASE +V +P T W DG PL + +V + R
Sbjct: 134 PASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERN--------- 184
Query: 189 QSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEE-VQLVVEPEGG 247
L + PA G + +SC H A A + E ++V+ P+
Sbjct: 185 ---LTLRPA-GPEHSGLYSCC------AHSAFGQACSSQNFTLSIADESFARVVLAPQDV 234
Query: 248 AVAPGGTVTLTCEVPAQPSPQIHWM-KDGVPL---PLPP---------SPVLILPEIGPQ 294
VA C+ AQP P + W+ +D P+ PP + L+L ++ P+
Sbjct: 235 VVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPR 294
Query: 295 DQGTYSCVATHSSHGP 310
+ G Y C+ GP
Sbjct: 295 NAGIYRCIG-QGQRGP 309
Score = 35.8 bits (81), Expect = 0.071
Identities = 33/125 (26%), Positives = 50/125 (40%), Gaps = 10/125 (8%)
Query: 211 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIH 270
SP PR L + + P + + + +P G L CEV A ++
Sbjct: 7 SPARPRRLPLLSVLLLPLLGGTQTA--IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVY 64
Query: 271 WMKDGVPLP------LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI-IEP 323
W+ DG P+ S + QD GT+ CVA G +E+R+ + S I+
Sbjct: 65 WLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG-EEARSANASFNIKW 123
Query: 324 GEEGP 328
E GP
Sbjct: 124 IEAGP 128
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 64.7 bits (156), Expect = 1e-10
Identities = 75/264 (28%), Positives = 110/264 (41%), Gaps = 38/264 (14%)
Query: 78 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG----KPEIVDSASEL 133
+LP G L + + +D GIF C A N R+ V +P I+ L
Sbjct: 188 LLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENL 247
Query: 134 TAGV-PNKVGTCVSEGSYPAGTLSW-HLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE 191
T V V CV+ G+ P +SW LDG+P+ +G+ V TG +
Sbjct: 248 TLTVHQTAVLECVATGN-PRPIVSWSRLDGRPI--GVEGIQVLG-------TGNLIISD- 296
Query: 192 LMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP 251
VT G + C+ + P R RTA Q R+ P E VQ P+ +
Sbjct: 297 --VTVQHSG----VYVCAANR--PGTRVRRTA--QGRLVVQAPAEFVQ---HPQSISRPA 343
Query: 252 GGTVTLTCEVPAQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVAT 304
G T TC+ +P P + W+K+G L + L + IGP+D+ Y CVA
Sbjct: 344 GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE 403
Query: 305 HSSHGPQESRAVSISIIEPGEEGP 328
+S+ Q S +++ E G GP
Sbjct: 404 NSAGSSQASARLTVLWAE-GLPGP 426
Score = 48.1 bits (113), Expect = 1e-05
Identities = 68/286 (23%), Positives = 102/286 (35%), Gaps = 45/286 (15%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFL---- 86
G+P+VL C+ PP R+ W+ N P + + +L NGSL +
Sbjct: 56 GQPIVLDCR-VEGTPPVRITWRKNGVEL------------PESTHSTLLANGSLMIRHFR 102
Query: 87 --PAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTC 144
P DEG + C A NR G R++ A+ ++ + T
Sbjct: 103 LEPGGSPSDEGDYECVAQNRFGLVVSRKARIQ-------------AATMSDFHVHPQATV 149
Query: 145 VSEGSYPAGTLSWHLDGKPLVPNEKG-VSVKEQTRRHPETGLFTLQSELMVTPARGGDPR 203
EG H KPL+ EK V + R+ + L +T R D
Sbjct: 150 GEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERY----TLLPKGVLQITGLRAED-G 204
Query: 204 PTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPA 263
F C S + R A + +E ++V PE + T L C
Sbjct: 205 GIFHCVAS-NIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263
Query: 264 QPSPQIHWMK-DGVPLPLPPSPV-----LILPEIGPQDQGTYSCVA 303
P P + W + DG P+ + V LI+ ++ Q G Y C A
Sbjct: 264 NPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAA 309
Score = 47.8 bits (112), Expect = 2e-05
Identities = 32/106 (30%), Positives = 41/106 (38%), Gaps = 25/106 (23%)
Query: 223 APIQPRVWEPVPL-------------EEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 269
AP+ PR+ P+ L E+ VEP PG + L C V P +I
Sbjct: 14 APLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRI 73
Query: 270 HWMKDGVPLPLPPSPVLIL------------PEIGPQDQGTYSCVA 303
W K+GV LP L+ P P D+G Y CVA
Sbjct: 74 TWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVA 119
Score = 38.5 bits (88), Expect = 0.011
Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 7/71 (9%)
Query: 242 VEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPL-------PLPPSPVLILPEIGPQ 294
V P+ GG C++ P P I W K+ VP+ L P VL + + +
Sbjct: 143 VHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAE 202
Query: 295 DQGTYSCVATH 305
D G + CVA++
Sbjct: 203 DGGIFHCVASN 213
Score = 38.5 bits (88), Expect = 0.011
Identities = 40/152 (26%), Positives = 68/152 (44%), Gaps = 25/152 (16%)
Query: 20 VVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVL 79
+VG +N+T + + VL+C A P + W GR + +G +VL
Sbjct: 241 LVGPENLTLTVHQTAVLECV-ATGNPRPIVSWSRLDGRP-----IGVEG-------IQVL 287
Query: 80 PNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVR-VYQIPGK----PEIVDSASELT 134
G+L + V +Q G++ C A NR G + + R V Q P + P+ + + T
Sbjct: 288 GTGNLIISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTT 346
Query: 135 AGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVP 166
A + TC ++G P ++W +G+ L P
Sbjct: 347 A-----MFTCQAQGE-PPPHVTWLKNGQVLGP 372
Score = 33.9 bits (76), Expect = 0.27
Identities = 31/111 (27%), Positives = 51/111 (45%), Gaps = 16/111 (14%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 83
Q+I+ G + C+ A +PP + W N +VL P G V N +
Sbjct: 337 QSISRPAGTTAMFTCQ-AQGEPPPHVTWLKNG------QVLGPGG-----HVRLKNNNST 384
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVY---QIPGKPEIVDSAS 131
L + +G +DE I++C A N G ++++ R+ V +PG P V + S
Sbjct: 385 LTISGIGPEDEAIYQCVAENSAG-SSQASARLTVLWAEGLPGPPRNVRAVS 434
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 63.5 bits (153), Expect = 3e-10
Identities = 77/316 (24%), Positives = 122/316 (38%), Gaps = 45/316 (14%)
Query: 26 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 85
+T + G+ +C A P LEW TG GG + A++ G L
Sbjct: 1875 LTVQPGQLAEFRCS-ATGSPTPTLEW---TGGP----------GGQLPAKAQI-HGGILR 1919
Query: 86 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
LPAV D+ + C+A + G++ V G P + S V
Sbjct: 1920 LPAVEPTDQAQYLCRAHSSAGQQVAR--AVLHVHGGGGPRVQVSPERTQVHAGRTVRLYC 1977
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 205
P+ T++W +G L P R T + TL + T G
Sbjct: 1978 RAAGVPSATITWRKEGGSLPPQA----------RSERTDIATLLIPAITTADAG-----F 2022
Query: 206 FSC-SFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQ 264
+ C + SP ++ + P P++ +E +V G T+ L C V
Sbjct: 2023 YLCVATSPAGTAQARIQVVVLSASDASPPPVK-----IESSSPSVTEGQTLDLNCVVAGS 2077
Query: 265 PSPQIHWMKDGVPLPLPPSPV----LILPEIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
Q+ W + G LP P + V L LP++ P D G Y C + S GP+E+ ++++S+
Sbjct: 2078 AHAQVTWYRRGGSLP-PHTQVHGSRLRLPQVSPADSGEYVCRVENGS-GPKEA-SITVSV 2134
Query: 321 IEPGEEGPTAGSVGGS 336
+ GP+ V GS
Sbjct: 2135 LHGTHSGPSYTPVPGS 2150
Score = 60.8 bits (146), Expect = 2e-09
Identities = 78/307 (25%), Positives = 117/307 (38%), Gaps = 51/307 (16%)
Query: 21 VGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLP 80
V + G + L C+ A P + W+ G L PQ +A
Sbjct: 1960 VSPERTQVHAGRTVRLYCRAAGV-PSATITWRKEGGS------LPPQARSERTDIA---- 2008
Query: 81 NGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI------PGKPEIVDSASELT 134
+L +PA+ D G + C A + G + R++V + P +I S+ +T
Sbjct: 2009 --TLLIPAITTADAGFYLCVATSPAGT---AQARIQVVVLSASDASPPPVKIESSSPSVT 2063
Query: 135 AGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMV 194
G + CV GS A ++W+ G L P+ + V R P+ V
Sbjct: 2064 EGQTLDLN-CVVAGSAHA-QVTWYRRGGSLPPHTQ---VHGSRLRLPQ-----------V 2107
Query: 195 TPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRV-----WEPVPLEEVQLVVEPEGGAV 249
+PA G+ + C G A T + + PVP + +EP V
Sbjct: 2108 SPADSGE----YVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHV 2163
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPL---PPSPVLILPEIGPQDQGTYSCVATHS 306
A G T+ L C VP Q Q+ W K G LP +L L ++ P D G Y C +
Sbjct: 2164 AEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGT 2223
Query: 307 SHGPQES 313
S GP E+
Sbjct: 2224 S-GPLEA 2229
Score = 60.1 bits (144), Expect = 4e-09
Identities = 70/256 (27%), Positives = 98/256 (38%), Gaps = 30/256 (11%)
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEI--------VDSASELTA 135
L L + + D G + C+A N N +++ + V G P ++S+S A
Sbjct: 2681 LRLHQMSVADSGEYVCRA-NNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA 2739
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
CV G A ++WH G L + + + + R H V+
Sbjct: 2740 EGETLDLNCVVPGQAHA-QVTWHKRGGSLPSHHQ--TRGSRLRLHH------------VS 2784
Query: 196 PARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTV 255
PA G+ S P A V P P + +EP VA G T+
Sbjct: 2785 PADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTL 2844
Query: 256 TLTCEVPAQPSPQIHWMKDGVPLPL---PPSPVLILPEIGPQDQGTYSCVATHSSHGPQE 312
L C VP Q Q+ W K G LP P+L L ++ P D G YSC T SS +
Sbjct: 2845 DLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEA 2904
Query: 313 SRAVSISIIEPGEEGP 328
S V+ IEP GP
Sbjct: 2905 SVLVT---IEPSSPGP 2917
Score = 59.3 bits (142), Expect = 6e-09
Identities = 78/292 (26%), Positives = 105/292 (35%), Gaps = 56/292 (19%)
Query: 27 TARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFL 86
T + G+ KC P LEWK E D+V + PNGS+ +
Sbjct: 3032 TVQQGQDASFKCLIHDGAAPISLEWKTRNQELE-------------DNV-HISPNGSI-I 3076
Query: 87 PAVGIQ--DEGIFRCQAMNRNG-KETKSNYRVR----VYQIPGKPEIVDSASELTAGVPN 139
VG + + G +RC A N G ++ N V V +P P V +T
Sbjct: 3077 TIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTL---- 3132
Query: 140 KVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARG 199
CVS G P + W K + R + GL + L ++ A+
Sbjct: 3133 ---ECVSAGE-PRSSARW--------TRISSTPAKLEQRTY---GLMDSHAVLQISSAKP 3177
Query: 200 GDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEP----VPLEEVQLVVEPEGGAVAPGGTV 255
D T+ C L + + P V EE +L VE G T
Sbjct: 3178 SDAG-TYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEA-------GHTA 3229
Query: 256 TLTCEVPAQPSPQIHWMKDGVPLPLP---PSPVLILPEIGPQDQGTYSCVAT 304
TL C P+P IHW K PLP LI+P + QD G Y C AT
Sbjct: 3230 TLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNAT 3281
Score = 58.5 bits (140), Expect = 1e-08
Identities = 77/309 (24%), Positives = 114/309 (36%), Gaps = 34/309 (11%)
Query: 19 AVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLN---TGRTEAWKVLSPQGGGPWDSV 75
+V G Q + PLV++ A PQ L +G + S + G P S
Sbjct: 1662 SVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSG 1721
Query: 76 ARVLPNGS-LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELT 134
+ GS L P+V D G++ C N + T S + V + P KP V + +
Sbjct: 1722 TQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNT-SRAELLVTEAPSKPITVTVEEQRS 1780
Query: 135 AGV---PNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSE 191
V + C ++ PA TL W +P TR G+ T+++
Sbjct: 1781 QSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLP----------TRAMDFNGILTIRNV 1830
Query: 192 LMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP 251
+ T+ C+ S + T +Q P+ + + P V P
Sbjct: 1831 QLSDAG-------TYVCTGSNMFAMDQGTATLHVQASGTLSAPV----VSIHPPQLTVQP 1879
Query: 252 GGTVTLTCEVPAQPSPQIHWM-KDGVPLPLPP---SPVLILPEIGPQDQGTYSCVATHSS 307
G C P+P + W G LP +L LP + P DQ Y C A HSS
Sbjct: 1880 GQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRA-HSS 1938
Query: 308 HGPQESRAV 316
G Q +RAV
Sbjct: 1939 AGQQVARAV 1947
Score = 53.1 bits (126), Expect = 4e-07
Identities = 66/259 (25%), Positives = 94/259 (36%), Gaps = 37/259 (14%)
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGK---------ETKSNYRVRVYQIPGKPEI-VDSASEL 133
L L V D G + C+ M +G E + V V G P I ++ +S
Sbjct: 2778 LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSR 2837
Query: 134 TAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELM 193
A CV G A ++WH G L RH G ++
Sbjct: 2838 VAEGQTLDLKCVVPGQAHA-QVTWHKRGGNL------------PARHQVHGPLLRLNQ-- 2882
Query: 194 VTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQ--LVVEPEGGAVAP 251
V+PA G+ +SC + A I+P P+P + + +E V
Sbjct: 2883 VSPADSGE----YSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTE 2938
Query: 252 GGTVTLTCEVPAQPSPQIHWMKDGVPLPL---PPSPVLILPEIGPQDQGTYSCVATHSSH 308
G T+ L C VP Q Q+ W K G LP L L + P D G Y C ++
Sbjct: 2939 GQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVC---RAAS 2995
Query: 309 GPQESRAVSISIIEPGEEG 327
GP + S ++ P EG
Sbjct: 2996 GPGPEQEASFTVTVPPSEG 3014
Score = 50.4 bits (119), Expect = 3e-06
Identities = 71/265 (26%), Positives = 98/265 (36%), Gaps = 33/265 (12%)
Query: 76 ARVLPNGSLF-LPAVGIQDEGIFRCQAMNRNGK-ETKSNYRVRVYQIPGK--PEIVDSAS 131
AR +GSL L V D G + C + +G E + IPG P ++S+S
Sbjct: 2194 ARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSS 2253
Query: 132 ELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETG--LFTLQ 189
A +CV G A ++W+ G L RH G L+ Q
Sbjct: 2254 STVAEGQTLDLSCVVAGQAHA-QVTWYKRGGSL------------PARHQVRGSRLYIFQ 2300
Query: 190 SELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAV 249
+ +PA G + C S G+ + Q + +EP V
Sbjct: 2301 A----SPADAGQ----YVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQV 2352
Query: 250 APGGTVTLTCEVPAQPSPQIHWMKDGVPLPL---PPSPVLILPEIGPQDQGTYSCVATHS 306
A G T+ L C VP Q Q+ W K G LP+ +L L + P D G Y C S
Sbjct: 2353 AEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGS 2412
Query: 307 SHGPQESRAVSISIIEPGEEGPTAG 331
S + S V+ IEP P G
Sbjct: 2413 SVPLEASVLVT---IEPAGSVPALG 2434
Score = 47.4 bits (111), Expect = 2e-05
Identities = 69/299 (23%), Positives = 109/299 (36%), Gaps = 43/299 (14%)
Query: 40 GAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGP---WDSVARVLP------NGSLFLPAVG 90
GAP+ + E + G T + + P W + LP +L +P V
Sbjct: 3210 GAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVA 3269
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 150
QD G + C A + G ++ + V P + + AS + AG ++ C++ G+
Sbjct: 3270 QQDSGQYICNATSPAG-HAEATIILHVESPPYATTVPEHAS-VQAGETVQL-QCLAHGTP 3326
Query: 151 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 210
P T W G L G T ++EL+ + + C
Sbjct: 3327 PL-TFQWSRVGSSL------------------PGRATARNELLHFERAAPEDSGRYRCRV 3367
Query: 211 SPGLPRHRALRTAPIQ-PRVWEP---VPLEEVQLV-VEPEGGAVAPGGTVTLTCEVPAQP 265
+ + A +Q P P +P V V P+ + G +V C VP+
Sbjct: 3368 TNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDR 3427
Query: 266 SPQIHWMKDGVPLPLPPS---PVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISII 321
Q+ W K+G LP S VL + + QGTY C A HGP S ++
Sbjct: 3428 GTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQA----HGPWGKAQASAQLV 3482
Score = 46.6 bits (109), Expect = 4e-05
Identities = 61/255 (23%), Positives = 91/255 (35%), Gaps = 37/255 (14%)
Query: 93 DEGIFRCQAMNRNGKETKSNYRVRVYQIPGK-------PEIVDSASELTAGVPNKVGTCV 145
D G + C+ + +G + S ++ G P ++S+S A C+
Sbjct: 2497 DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCL 2556
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPT 205
P T++W+ G L + V + R P+ VTPA G+
Sbjct: 2557 VASQAPH-TITWYKRGGSLPSRHQIVGSR---LRIPQ-----------VTPADSGE---- 2597
Query: 206 FSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQP 265
+ C S G IQ VP + +E V G T+ L C V QP
Sbjct: 2598 YVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQP 2657
Query: 266 SPQIHWMKDGVPLP---LPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIE 322
I W K G LP L L ++ D G Y C A ++ + S +S+S
Sbjct: 2658 QAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVS--- 2714
Query: 323 PGEEGPTAGSVGGSG 337
P+AGS G
Sbjct: 2715 -----PSAGSPSAPG 2724
Score = 44.3 bits (103), Expect = 2e-04
Identities = 26/68 (38%), Positives = 32/68 (47%), Gaps = 9/68 (13%)
Query: 244 PEGGAVAPGGTVTLTCEVPAQPSPQIHWMK-DGVPLPLPPSP-----VLILPEIGPQDQG 297
P+ V G C P+P I W K DG LPP +L+LP + PQD G
Sbjct: 3581 PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDG---SLPPDSRLENNMLMLPSVRPQDAG 3637
Query: 298 TYSCVATH 305
TY C AT+
Sbjct: 3638 TYVCTATN 3645
Score = 38.9 bits (89), Expect = 0.008
Identities = 27/80 (33%), Positives = 34/80 (42%), Gaps = 3/80 (3%)
Query: 242 VEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL---PPSPVLILPEIGPQDQGT 298
+E VA G T+ L C V Q Q+ W K G LP L L ++ P D G
Sbjct: 2441 IESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGE 2500
Query: 299 YSCVATHSSHGPQESRAVSI 318
Y C SS + S V+I
Sbjct: 2501 YVCRVVGSSGTQEASVLVTI 2520
Score = 36.6 bits (83), Expect = 0.042
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 10/78 (12%)
Query: 239 QLVVEP-EGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPP---------SPVLIL 288
Q+V P E + G TVT TC P+P I+W + +P P LI+
Sbjct: 407 QVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLII 466
Query: 289 PEIGPQDQGTYSCVATHS 306
++ DQG Y+C A ++
Sbjct: 467 RDVKESDQGAYTCEAMNA 484
Score = 36.2 bits (82), Expect = 0.054
Identities = 74/326 (22%), Positives = 121/326 (37%), Gaps = 61/326 (18%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVG 90
G+ L LKC P + ++ W G A Q GP + +V P
Sbjct: 2841 GQTLDLKCV-VPGQAHAQVTWHKRGGNLPA----RHQVHGPLLRLNQVSP---------- 2885
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG--------KPEIVD-SASELTAGVPNKV 141
D G + CQ +G S PG +P ++ S+S +T G +
Sbjct: 2886 -ADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDL 2944
Query: 142 GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD 201
CV G A ++W+ G L + + Q R H +V+PA G+
Sbjct: 2945 N-CVVPGQAHA-QVTWYKRGGSLPARHQ--THGSQLRLH------------LVSPADSGE 2988
Query: 202 PRPTFSCSFSPGL-PRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCE 260
+ C + G P A T + P L + ++P V G + C
Sbjct: 2989 ----YVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCL 3044
Query: 261 VPAQPSP-QIHW------MKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQES 313
+ +P + W ++D V + P ++ + P + GTY CVA+ +++G +S
Sbjct: 3045 IHDGAAPISLEWKTRNQELEDNVHIS-PNGSIITIVGTRPSNHGTYRCVAS-NAYGVAQS 3102
Query: 314 RAVSISIIEPG-----EEGPTAGSVG 334
V++S+ P EGP VG
Sbjct: 3103 -VVNLSVHGPPTVSVLPEGPVWVKVG 3127
Score = 33.9 bits (76), Expect = 0.27
Identities = 51/221 (23%), Positives = 78/221 (35%), Gaps = 30/221 (13%)
Query: 104 RNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKV-GTCVSEGSYPAGTLSWHLDGK 162
R E YR RV G E A L G P + T + GS P ++ L+ K
Sbjct: 3354 RAAPEDSGRYRCRVTNKVGSAEAF--AQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETK 3411
Query: 163 PL---------VPNEKGVSVKEQTRRHPETGLF----TLQSELMVTPARGGDPRPTFSCS 209
+ VP+++G Q R E G ++Q ++ + T+ C
Sbjct: 3412 SIGASVEFHCAVPSDRGT----QLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQ 3467
Query: 210 FSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQI 269
+ +A IQ L V + + V G V C P PQ+
Sbjct: 3468 AHGPWGKAQASAQLVIQA-------LPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQV 3520
Query: 270 HWMKDG---VPLPLPPSPVLILPEIGPQDQGTYSCVATHSS 307
W K G P + V+ + + D G Y C AT+++
Sbjct: 3521 TWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAA 3561
Score = 33.1 bits (74), Expect = 0.46
Identities = 31/106 (29%), Positives = 40/106 (37%), Gaps = 16/106 (15%)
Query: 2 AAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAW 61
AAGT +L++ + Q + G V C + P +W
Sbjct: 3560 AAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDI-----------SW 3608
Query: 62 KVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGK 107
L G P DS L N L LP+V QD G + C A NR GK
Sbjct: 3609 SKLD--GSLPPDSR---LENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
Score = 32.0 bits (71), Expect = 1.0
Identities = 30/102 (29%), Positives = 39/102 (38%), Gaps = 13/102 (12%)
Query: 242 VEPEGGA-VAPGGTVTLTCEVPAQPSPQIHWMK-DGVPLPLPPSP--------VLILPEI 291
V PEG V G VTL C +P W + P L VL +
Sbjct: 3116 VLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSA 3175
Query: 292 GPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSV 333
P D GTY C+A ++ Q+ V I++ G P A V
Sbjct: 3176 KPSDAGTYVCLAQNALGTAQKQVEV---IVDTGAMAPGAPQV 3214
Score = 30.0 bits (66), Expect = 3.9
Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 14/85 (16%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWK--VLSPQGGGPWDSVARVLPN 81
++I A G+ + C A P + W+LN G + ++ +GG
Sbjct: 414 ESIQASRGQTVTFTCV-AIGVPTPIINWRLNWGHIPSHPRVTVTSEGG-----------R 461
Query: 82 GSLFLPAVGIQDEGIFRCQAMNRNG 106
G+L + V D+G + C+AMN G
Sbjct: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
Length = 1007
Score = 61.6 bits (148), Expect = 1e-09
Identities = 65/199 (32%), Positives = 87/199 (43%), Gaps = 40/199 (20%)
Query: 143 TCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH--PETGLFTLQSELMVTPARG- 199
+C + G P T+ W L+G+PL S+ H P+ L LQ PARG
Sbjct: 52 SCQASGQ-PPPTIRWLLNGQPL-------SMVPPDPHHLLPDGTLLLLQP-----PARGH 98
Query: 200 ---GDPRPT----FSCSFSPGLPRHRALRTAPIQ-PRVWEPVPLEEVQLVVEPEGGAVAP 251
G T ++C S L TA + R+ V E+ Q ++P
Sbjct: 99 AHDGQALSTDLGVYTCEAS------NRLGTAVSRGARLSVAVLREDFQ--IQPRDMVAVV 150
Query: 252 GGTVTLTCEVP-AQPSPQIHWMKDGVPLPLPP------SPVLILPEIGPQDQGTYSCVAT 304
G TL C P P P + W KDG PL L P L++ D+GTY CVAT
Sbjct: 151 GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVAT 210
Query: 305 HSSHGPQESRAVSISIIEP 323
+S+ G +ESRA +SI EP
Sbjct: 211 NSA-GHRESRAARVSIQEP 228
Score = 50.1 bits (118), Expect = 4e-06
Identities = 75/290 (25%), Positives = 108/290 (37%), Gaps = 68/290 (23%)
Query: 33 PLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFL---PAV 89
P + C+ A +PP + W LN P P D +LP+G+L L PA
Sbjct: 48 PARMSCQ-ASGQPPPTIRWLLNG---------QPLSMVPPDP-HHLLPDGTLLLLQPPAR 96
Query: 90 G--------IQDEGIFRCQAMNRNGKETKSNYRVRV------YQIPGKPEIVDSASELTA 135
G D G++ C+A NR G R+ V +QI + + + T
Sbjct: 97 GHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTL 156
Query: 136 GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVT 195
C +P T+SW DGKPL Q RH +G L++
Sbjct: 157 -------ECGPPWGHPEPTVSWWKDGKPLA---------LQPGRHTVSG-----GSLLMA 195
Query: 196 PARGGDPRPTFSC--SFSPGLPRHRALRTAPIQPRVW-EPVPLEEVQLVVEPEGGAVAPG 252
A D T+ C + S G RA R + +P+ + EPV L V++ +E
Sbjct: 196 RAEKSD-EGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLE--------- 245
Query: 253 GTVTLTCEVPAQ-----PSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQG 297
VTL PA+ P+ + W G P L + P QG
Sbjct: 246 -NVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
Score = 41.6 bits (96), Expect = 0.001
Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 20/101 (19%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL-PPSPVLILPE-----IG 292
Q++V P+ G ++C+ QP P I W+ +G PL + PP P +LP+ +
Sbjct: 33 QILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQ 92
Query: 293 P-------------QDQGTYSCVATHSSHGPQESRAVSISI 320
P D G Y+C A++ G SR +S+
Sbjct: 93 PPARGHAHDGQALSTDLGVYTCEASNRL-GTAVSRGARLSV 132
Score = 30.0 bits (66), Expect = 3.9
Identities = 36/146 (24%), Positives = 52/146 (35%), Gaps = 16/146 (10%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 83
+++ A +GE L+C P + W WK P P + GS
Sbjct: 144 RDMVAVVGEQFTLECGPPWGHPEPTVSW---------WKDGKPLALQPG---RHTVSGGS 191
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVD-SASELTAGVPNKVG 142
L + DEG + C A N G RV + + E V+ A + +
Sbjct: 192 LLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLN 251
Query: 143 TCVSEG--SYPAGTLSWHLDGKPLVP 166
+EG PA LSW + G P P
Sbjct: 252 PDPAEGPKPRPAVWLSWKVSG-PAAP 276
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 60.8 bits (146), Expect = 2e-09
Identities = 77/295 (26%), Positives = 110/295 (37%), Gaps = 66/295 (22%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV- 89
GEP L CK A +P +EW + R E K P+ S +LP+GSLF +
Sbjct: 61 GEPTTLNCK-AEGRPTPTIEWYKDGERVETDKD-DPR------SHRMLLPSGSLFFLRIV 112
Query: 90 ----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
DEG + C A N G+ N + V + + + AG P + C
Sbjct: 113 HGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP-AILECQ 171
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKE-----QTRRHPETGLFTLQSELMVTPARGG 200
+P T+ W D + E+ +S++ R + G++T MV R
Sbjct: 172 PPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE-RDS 230
Query: 201 DP-------RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGG 253
DP RPTF LR PI Q+V+E E
Sbjct: 231 DPAELTVFERPTF-------------LRR-PIN------------QVVLEEEA------- 257
Query: 254 TVTLTCEVPAQPSPQIHWMKDGVPLP-----LPPSPVLILPEIGPQDQGTYSCVA 303
V C+V P P + W KD LP + L + + D+GTY C+A
Sbjct: 258 -VEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIA 311
Score = 48.1 bits (113), Expect = 1e-05
Identities = 62/301 (20%), Positives = 101/301 (33%), Gaps = 70/301 (23%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARV-LPNGS 83
++ GEP +L+C+ P + WK + R + D R+ + G
Sbjct: 157 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID-------------DKEERISIRGGK 203
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIP-------GKPEIVDSASELTAG 136
L + D G++ C N G+ + V++ P + + + A E
Sbjct: 204 LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF--- 260
Query: 137 VPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTP 196
C +G P T+ W D L +K+ +TL+ + ++
Sbjct: 261 ------RCQVQGD-PQPTVRWKKDDADLPRGR--YDIKDD---------YTLRIKKTMST 302
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
G T+ C + + A T ++ Q VV P VA G TVT
Sbjct: 303 DEG-----TYMCIAENRVGKMEASATLTVR---------APPQFVVRPRDQIVAQGRTVT 348
Query: 257 LTCEVPAQPSPQIHWMKDGVP--------------LPLPPSPVLILPEIGPQDQGTYSCV 302
CE P P + W K+G + P+ L + I D G Y C
Sbjct: 349 FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQ 408
Query: 303 A 303
A
Sbjct: 409 A 409
Score = 45.4 bits (106), Expect = 9e-05
Identities = 60/232 (25%), Positives = 89/232 (38%), Gaps = 41/232 (17%)
Query: 93 DEGIFRCQAMNRNGK-ETKSNYRVRVYQIPGKPE-IVDSASELTAGVPNKVGTCVSEGSY 150
DEG + C A NR GK E + VR P+ +V ++ A C ++G+
Sbjct: 303 DEGTYMCIAENRVGKMEASATLTVRA-----PPQFVVRPRDQIVAQGRTVTFPCETKGN- 356
Query: 151 PAGTLSWHLDGKP--LVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC 208
P + W +G L PN+ + P S V+P GD T
Sbjct: 357 PQPAVFWQKEGSQNLLFPNQP---------QQPN-------SRCSVSPT--GDLTITNIQ 398
Query: 209 SFSPGLPRHRALRTA-----PIQPRVWEPVPLEEVQLVVE-PEGGAVAPGGTVTLTCEVP 262
G +AL A Q V + + ++++ P +A GT L C+
Sbjct: 399 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKAT 458
Query: 263 AQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSS 307
P P I W+K+G P + L + + D GTY+CVAT SS
Sbjct: 459 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS 510
Score = 38.5 bits (88), Expect = 0.011
Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 17/98 (17%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL----PPSPVLILP----- 289
++V P V+ G TL C+ +P+P I W KDG + P S ++LP
Sbjct: 48 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLF 107
Query: 290 -------EIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
D+G+Y CVA + G SR S+ +
Sbjct: 108 FLRIVHGRRSKPDEGSYVCVA-RNYLGEAVSRNASLEV 144
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 60.8 bits (146), Expect = 2e-09
Identities = 77/295 (26%), Positives = 110/295 (37%), Gaps = 66/295 (22%)
Query: 31 GEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAV- 89
GEP L CK A +P +EW + R E K P+ S +LP+GSLF +
Sbjct: 45 GEPTTLNCK-AEGRPTPTIEWYKDGERVETDKD-DPR------SHRMLLPSGSLFFLRIV 96
Query: 90 ----GIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 145
DEG + C A N G+ N + V + + + AG P + C
Sbjct: 97 HGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP-AILECQ 155
Query: 146 SEGSYPAGTLSWHLDGKPLVPNEKGVSVKE-----QTRRHPETGLFTLQSELMVTPARGG 200
+P T+ W D + E+ +S++ R + G++T MV R
Sbjct: 156 PPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE-RDS 214
Query: 201 DP-------RPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGG 253
DP RPTF LR PI Q+V+E E
Sbjct: 215 DPAELTVFERPTF-------------LRR-PIN------------QVVLEEEA------- 241
Query: 254 TVTLTCEVPAQPSPQIHWMKDGVPLP-----LPPSPVLILPEIGPQDQGTYSCVA 303
V C+V P P + W KD LP + L + + D+GTY C+A
Sbjct: 242 -VEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIA 295
Score = 48.1 bits (113), Expect = 1e-05
Identities = 62/301 (20%), Positives = 101/301 (33%), Gaps = 70/301 (23%)
Query: 25 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARV-LPNGS 83
++ GEP +L+C+ P + WK + R + D R+ + G
Sbjct: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID-------------DKEERISIRGGK 187
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIP-------GKPEIVDSASELTAG 136
L + D G++ C N G+ + V++ P + + + A E
Sbjct: 188 LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF--- 244
Query: 137 VPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTP 196
C +G P T+ W D L +K+ +TL+ + ++
Sbjct: 245 ------RCQVQGD-PQPTVRWKKDDADLPRGR--YDIKDD---------YTLRIKKTMST 286
Query: 197 ARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVT 256
G T+ C + + A T ++ Q VV P VA G TVT
Sbjct: 287 DEG-----TYMCIAENRVGKMEASATLTVR---------APPQFVVRPRDQIVAQGRTVT 332
Query: 257 LTCEVPAQPSPQIHWMKDGVP--------------LPLPPSPVLILPEIGPQDQGTYSCV 302
CE P P + W K+G + P+ L + I D G Y C
Sbjct: 333 FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQ 392
Query: 303 A 303
A
Sbjct: 393 A 393
Score = 45.4 bits (106), Expect = 9e-05
Identities = 60/232 (25%), Positives = 89/232 (38%), Gaps = 41/232 (17%)
Query: 93 DEGIFRCQAMNRNGK-ETKSNYRVRVYQIPGKPE-IVDSASELTAGVPNKVGTCVSEGSY 150
DEG + C A NR GK E + VR P+ +V ++ A C ++G+
Sbjct: 287 DEGTYMCIAENRVGKMEASATLTVRA-----PPQFVVRPRDQIVAQGRTVTFPCETKGN- 340
Query: 151 PAGTLSWHLDGKP--LVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSC 208
P + W +G L PN+ + P S V+P GD T
Sbjct: 341 PQPAVFWQKEGSQNLLFPNQP---------QQPN-------SRCSVSPT--GDLTITNIQ 382
Query: 209 SFSPGLPRHRALRTA-----PIQPRVWEPVPLEEVQLVVE-PEGGAVAPGGTVTLTCEVP 262
G +AL A Q V + + ++++ P +A GT L C+
Sbjct: 383 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKAT 442
Query: 263 AQPSPQIHWMKDGVPLP-------LPPSPVLILPEIGPQDQGTYSCVATHSS 307
P P I W+K+G P + L + + D GTY+CVAT SS
Sbjct: 443 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS 494
Score = 38.5 bits (88), Expect = 0.011
Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 17/98 (17%)
Query: 239 QLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPL----PPSPVLILP----- 289
++V P V+ G TL C+ +P+P I W KDG + P S ++LP
Sbjct: 32 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLF 91
Query: 290 -------EIGPQDQGTYSCVATHSSHGPQESRAVSISI 320
D+G+Y CVA + G SR S+ +
Sbjct: 92 FLRIVHGRRSKPDEGSYVCVA-RNYLGEAVSRNASLEV 128
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 60.8 bits (146), Expect = 2e-09
Identities = 69/261 (26%), Positives = 115/261 (44%), Gaps = 44/261 (16%)
Query: 78 VLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETK---SNYRVRVYQIPGKPEIVDSASELT 134
++P+G+L + +DEG+++C A N +E K S+ R+RV + + + E
Sbjct: 179 IMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQ 238
Query: 135 AGVPNK----VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQS 190
+ K + CV+ G P ++W DG + K TR F L +
Sbjct: 239 TIIVTKGQSLILECVASG-IPPPRVTWAKDGSSVTGYNK-------TR-------FLLSN 283
Query: 191 ELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEP--VPLEEVQLVVEPEGGA 248
L+ T + + T+ C G+ + A +V+EP V +E QLV+
Sbjct: 284 LLIDTTSE--EDSGTYRCMADNGVGQPGAA-VILYNVQVFEPPEVTMELSQLVIPW---- 336
Query: 249 VAPGGTVTLTCEVPAQPSPQIHWMKDGVP------LPLPPSPVLILPEIGPQDQGTYSCV 302
G + LTCEV P P + W+++ VP L L + +L +GP+D+G Y C+
Sbjct: 337 ---GQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVL-SMGPEDEGVYQCM 392
Query: 303 ATH---SSHGPQESRAVSISI 320
A + S+H + R SI
Sbjct: 393 AENEVGSAHAVVQLRTSRPSI 413
Score = 36.6 bits (83), Expect = 0.042
Identities = 41/155 (26%), Positives = 66/155 (42%), Gaps = 31/155 (20%)
Query: 23 AQNITARIGEPLVLKCKGAPKKPPQRLEWKLN----TGRTEAWKVLSPQGGGPWDSVARV 78
AQ I G+ L+L+C A PP R+ W + TG + +LS
Sbjct: 237 AQTIIVTKGQSLILECV-ASGIPPPRVTWAKDGSSVTGYNKTRFLLS------------- 282
Query: 79 LPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKS--NYRVRVYQIPGKPEIVDSASELTA- 135
+L + +D G +RC A N G+ + Y V+V++ PE+ S+L
Sbjct: 283 ----NLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFE---PPEVTMELSQLVIP 335
Query: 136 -GVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEK 169
G K+ TC G+ P L W + PL+ +++
Sbjct: 336 WGQSAKL-TCEVRGNPPPSVL-WLRNAVPLISSQR 368
Score = 31.6 bits (70), Expect = 1.3
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 9/76 (11%)
Query: 236 EEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPL--------PLPPSPVLI 287
E Q+ V+P PGGTV L C V P + W +G L L L+
Sbjct: 34 EVPQVTVQPASTVQKPGGTVILGC-VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLV 92
Query: 288 LPEIGPQDQGTYSCVA 303
+ + G Y CVA
Sbjct: 93 ITALNNHTVGRYQCVA 108
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 60.1 bits (144), Expect = 4e-09
Identities = 75/331 (22%), Positives = 121/331 (36%), Gaps = 51/331 (15%)
Query: 24 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 83
+ + GE + ++C P +L+W G GP + + G+
Sbjct: 248 ETLVVNPGENVTVQCLLTGGDPLPQLQWS--------------HGPGPLP-LGALAQGGT 292
Query: 84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG-----KPEIVDSASELTAGVP 138
L +P+V +D G + C A N G K + V + P+++ + + G
Sbjct: 293 LSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQD 352
Query: 139 NKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPAR 198
K+ V T W +GKP +++ + TR PE T EL+
Sbjct: 353 LKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLL----VTRNDPELPAVTSSLELIDLHF- 407
Query: 199 GGDPRPTFSCSFS-PGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVA---PGGT 254
T+ C S PG P I P + P+G AV G
Sbjct: 408 --SDYGTYLCMASFPGAPVPDLSVEVNISSETVPPT-------ISVPKGRAVVTVREGSP 458
Query: 255 VTLTCEVPAQPSPQIHW---------MKDGVPLPLPPSPVLILPEIGPQDQGTYSC-VAT 304
L CEV +P P + W + G+PL P L L + GTY C A
Sbjct: 459 AELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTAR 518
Query: 305 HSSHG--PQESRAVSISIIEPGEEGPTAGSV 333
++ P+E++ V +++ P E P++ V
Sbjct: 519 YNGFNVRPREAQ-VQLNVQFPPEVEPSSQDV 548
>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
Length = 388
Score = 59.7 bits (143), Expect = 5e-09
Identities = 78/315 (24%), Positives = 130/315 (41%), Gaps = 44/315 (13%)
Query: 91 IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 150
++DEG + CQ + + V V P P +V+ + G ++ +C+ S
Sbjct: 96 LEDEGGYFCQLYTEDTHHQIATLTVLV--APENP-VVEVREQAVEGGEVEL-SCLVPRSR 151
Query: 151 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 210
PA TL W+ D K L KGVS ++ + ++++ S + R D +
Sbjct: 152 PAATLRWYRDRKEL----KGVSSSQENGK-----VWSVASTVRFRVDRKDDGGIIICEAQ 202
Query: 211 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSP-QI 269
+ LP + +T + + P + V G T+ LTC V P P QI
Sbjct: 203 NQALPSGHSKQTQYVLDVQYSPTAR------IHASQAVVREGDTLVLTCAVTGNPRPNQI 256
Query: 270 HWMKDGVPLPLPPSPV---LILPEIGPQDQGTYSCVATHSSHGPQESRAVSISII-EPGE 325
W + LP V L LP + D GTY+C A+ + HG +RA+ + ++ +PG
Sbjct: 257 RWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEAS-NKHG--HARALYVLVVYDPGA 313
Query: 326 EGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQR-------------RGEE 372
SV + +G + L L +L+G++ RQ+ +GE
Sbjct: 314 VVEAQTSVPYAIVGGILALLVFL----IICVLVGMVWCSVRQKGSYLTHEASGLDEQGEA 369
Query: 373 RKAPENQEEEEERAE 387
R+A N + +R E
Sbjct: 370 REAFLNGSDGHKRKE 384
Score = 29.6 bits (65), Expect = 5.1
Identities = 27/104 (25%), Positives = 41/104 (39%), Gaps = 17/104 (16%)
Query: 19 AVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARV 78
A + A R G+ LVL C P ++ W N G + G
Sbjct: 226 ARIHASQAVVREGDTLVLTCAVTGNPRPNQIRW--NRGNESLPERAEAVGE--------- 274
Query: 79 LPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPG 122
+L LP + D G + C+A N++G ++ Y + VY PG
Sbjct: 275 ----TLTLPGLVSADNGTYTCEASNKHG-HARALYVLVVYD-PG 312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.134 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,977,962
Number of Sequences: 37866
Number of extensions: 1216858
Number of successful extensions: 9112
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 255
Number of HSP's successfully gapped in prelim test: 294
Number of HSP's that attempted gapping in prelim test: 6134
Number of HSP's gapped (non-prelim): 2403
length of query: 404
length of database: 18,247,518
effective HSP length: 105
effective length of query: 299
effective length of database: 14,271,588
effective search space: 4267204812
effective search space used: 4267204812
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.