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Search of human proteins with 239743309
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239743309 PREDICTED: similar to calcium-promoted Ras
inactivator isoform 2 [Homo sapiens]
(731 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 1467 0.0
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 1467 0.0
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 1460 0.0
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 1356 0.0
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 1356 0.0
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 1348 0.0
gi|4759026 RAS protein activator like 1 [Homo sapiens] 620 e-177
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 293 3e-79
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 283 3e-76
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 132 9e-31
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 132 9e-31
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 118 2e-26
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 118 2e-26
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 115 1e-25
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 105 1e-22
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 105 1e-22
gi|130502162 RAS protein activator like 3 [Homo sapiens] 87 5e-17
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 84 5e-16
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 84 5e-16
gi|13384594 protein kinase C, gamma [Homo sapiens] 81 3e-15
gi|4506067 protein kinase C, alpha [Homo sapiens] 79 1e-14
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 77 6e-14
gi|150170670 piccolo isoform 2 [Homo sapiens] 75 3e-13
gi|150378539 piccolo isoform 1 [Homo sapiens] 75 3e-13
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 72 2e-12
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 72 2e-12
gi|38570146 synaptotagmin VII [Homo sapiens] 70 5e-12
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 69 2e-11
gi|47078261 double C2-like domains, alpha [Homo sapiens] 64 4e-10
gi|40068038 B/K protein [Homo sapiens] 64 4e-10
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 1467 bits (3799), Expect = 0.0
Identities = 731/731 (100%), Positives = 731/731 (100%)
Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS
Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS
Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
Query: 721 SEPNCLLELQT 731
SEPNCLLELQT
Sbjct: 721 SEPNCLLELQT 731
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 1467 bits (3799), Expect = 0.0
Identities = 731/731 (100%), Positives = 731/731 (100%)
Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS
Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS
Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
Query: 721 SEPNCLLELQT 731
SEPNCLLELQT
Sbjct: 721 SEPNCLLELQT 731
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 1460 bits (3779), Expect = 0.0
Identities = 728/731 (99%), Positives = 729/731 (99%)
Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132
Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312
Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAGMQYLHGVLGPII
Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPII 372
Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432
Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492
Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLKDFITKLVDIEEK
Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEK 552
Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS
Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 612
Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS
Sbjct: 613 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 672
Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLI R
Sbjct: 673 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICR 732
Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 733 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 792
Query: 721 SEPNCLLELQT 731
SEPNCLLELQT
Sbjct: 793 SEPNCLLELQT 803
Score = 43.5 bits (101), Expect = 7e-04
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L
Sbjct: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61
Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
A+ D D +SR+D +GKV +
Sbjct: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 1356 bits (3510), Expect = 0.0
Identities = 685/731 (93%), Positives = 685/731 (93%), Gaps = 46/731 (6%)
Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132
Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312
Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 372
Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432
Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492
Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 552
Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS
Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609
Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
KCVNELNQWLSALRKVS
Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626
Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 686
Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746
Query: 721 SEPNCLLELQT 731
SEPNCLLELQT
Sbjct: 747 SEPNCLLELQT 757
Score = 43.5 bits (101), Expect = 7e-04
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L
Sbjct: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61
Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
A+ D D +SR+D +GKV +
Sbjct: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 1356 bits (3510), Expect = 0.0
Identities = 685/731 (93%), Positives = 685/731 (93%), Gaps = 46/731 (6%)
Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132
Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312
Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 372
Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432
Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492
Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 552
Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS
Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609
Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
KCVNELNQWLSALRKVS
Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626
Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 686
Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746
Query: 721 SEPNCLLELQT 731
SEPNCLLELQT
Sbjct: 747 SEPNCLLELQT 757
Score = 43.5 bits (101), Expect = 7e-04
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L
Sbjct: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61
Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
A+ D D +SR+D +GKV +
Sbjct: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 1348 bits (3490), Expect = 0.0
Identities = 682/731 (93%), Positives = 683/731 (93%), Gaps = 46/731 (6%)
Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132
Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312
Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAGMQYLHGVLGPII
Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPII 372
Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432
Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492
Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLKDFITKLVDIEEK
Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEK 552
Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS
Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609
Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
KCVNELNQWLSALRKVS
Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626
Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLI R
Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICR 686
Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746
Query: 721 SEPNCLLELQT 731
SEPNCLLELQT
Sbjct: 747 SEPNCLLELQT 757
Score = 43.5 bits (101), Expect = 7e-04
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L
Sbjct: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61
Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
A+ D D +SR+D +GKV +
Sbjct: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 620 bits (1599), Expect = e-177
Identities = 337/722 (46%), Positives = 461/722 (63%), Gaps = 19/722 (2%)
Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
+DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI L +++ +
Sbjct: 73 LDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQG 132
Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W+E E GA
Sbjct: 133 RCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGA 192
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
L VE WDWD+V +NDFLG V + L+ + +GWFRL P ++ GNLG+L
Sbjct: 193 PSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRLLPFP-RAEEDSGGNLGAL 250
Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL-----IPLIEETTSTECRQDVA 235
+++VRL ++ VLPS YQPL+ LL V QGP + + L+EE T +CRQD+A
Sbjct: 251 RVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLEELTLGDCRQDLA 306
Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGV 295
T L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKS+E F+K+ GM YLH V
Sbjct: 307 TKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEV 366
Query: 296 LGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSAL 355
L P+I++VFEEKKY+ELDP K+++ +E ++ E S L +LG ++ A+
Sbjct: 367 LKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAI 426
Query: 356 SRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHL 415
SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF+PAI++PKLF L
Sbjct: 427 VGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDL 486
Query: 416 RERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLV 475
R++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q V++++DF+ +LV
Sbjct: 487 RDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLV 546
Query: 476 DIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP 535
D++ + R L + V+EG L + + G +FKK Y L+ E LSF+K+P
Sbjct: 547 DVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSP 606
Query: 536 SSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSA 595
+ I +++IRA E+V+E +F HVMQV+ D G T YLQCK VNELNQWLSA
Sbjct: 607 EWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSA 666
Query: 596 LRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEA 655
LRK S N L + HPG FR +W+CC Q E++ GC +T S VTL +W+DPLD D EA
Sbjct: 667 LRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEA 726
Query: 656 QLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSLARLLRVLQDLRE 709
Q +YR LL L R + L T+ G PE + ARLL VL DL
Sbjct: 727 QTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDR 784
Query: 710 AH 711
AH
Sbjct: 785 AH 786
Score = 40.4 bits (93), Expect = 0.006
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 2/87 (2%)
Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
A++ L V+E R L KD +G+SDP+ V+ T+ V +S P W E + L
Sbjct: 2 AKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHL 61
Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKV 143
L D D V +D +GK+
Sbjct: 62 PLD-FHQLAFYVLDEDTVGHDDIIGKI 87
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 293 bits (751), Expect = 3e-79
Identities = 211/723 (29%), Positives = 349/723 (48%), Gaps = 65/723 (8%)
Query: 2 DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE----VWPG 57
D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L+ +
Sbjct: 108 DKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLELKLNELITEN 166
Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSCYPRWNETF- 112
C+ ++A P + DP+ V G +R +T + KK+ P++NE F
Sbjct: 167 GTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFY 226
Query: 113 -------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEE 157
+F+++E +E L ++ W+ + ++ FLG++ + V LR +
Sbjct: 227 FEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQ 286
Query: 158 GWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ 217
W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL +
Sbjct: 287 AWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASA 346
Query: 218 LIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLAS 277
L E + D L++L L F + +L+L T + NT+FR NSLA+
Sbjct: 347 AYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLAT 403
Query: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337
+ ++ +K+ G YL L PI++++ + K E+DP K++ E + +
Sbjct: 404 RCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK--------------EGDNV 449
Query: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397
E + + LR ++ L + + +S +CP V+ F L + +RFP H V + AV+SF
Sbjct: 450 ENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH--VQYSAVSSF 507
Query: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPASRAKEAWM- 453
+ LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++ S KE +M
Sbjct: 508 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMC 567
Query: 454 EPLQPTVHQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512
E + +G + +K F+ ++ E K+ + L KEG ++ R +G+ +
Sbjct: 568 EFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY-KRAQGRTRI 621
Query: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572
+FKK +F LT+ L++ K P I + NI A EK+EE SF ++ QVI+T+
Sbjct: 622 GKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTE- 680
Query: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632
+ Y+Q E N+W+ L +VS N L YHP V+ W CC + + G
Sbjct: 681 ----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLG 736
Query: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKV 692
C + V D +D D E + IY L + + ++ E G V P K
Sbjct: 737 CKPCTAGVPADIQID-IDEDRETERIY-SLFTLSLLKLQKMEEACGTI---AVYQGPQKE 791
Query: 693 PED 695
P+D
Sbjct: 792 PDD 794
Score = 45.8 bits (107), Expect = 1e-04
Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 10/152 (6%)
Query: 63 LRCSVLEARDLAPK-DRNGTSDPFVRVRY-KGRTRETSIVKKSCYPRWNETFEFELQEGA 120
LR + EA++L P + D F + + T +V+KS P ++E F FE+
Sbjct: 40 LRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPR-T 98
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
+ L +D +++ R+ +GKV I + L +E WF LQP S S G +
Sbjct: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQ-----GKV 153
Query: 181 QLEVRLRDETVLPSSYYQPL-VHL-LCHEVKL 210
LE++L + + Q L VH+ CH + L
Sbjct: 154 HLELKLNELITENGTVCQQLVVHIKACHGLPL 185
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 283 bits (725), Expect = 3e-76
Identities = 206/687 (29%), Positives = 328/687 (47%), Gaps = 63/687 (9%)
Query: 2 DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWP----- 56
D D RD +IGKV + ++ + + + W L VD D EVQG++HL L +
Sbjct: 82 DRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLELRLSEVITDT 140
Query: 57 GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKSCYPRWNETF 112
G +L ++E + L NG DP+ V ++ ++T + +K+ P+++E F
Sbjct: 141 GVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVF 198
Query: 113 EFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVIDVQRLRVVQQ 155
FE+ +E ++ L + W+ L ++FLG++ I ++ LR
Sbjct: 199 YFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSS 258
Query: 156 EEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215
E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL +
Sbjct: 259 YEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSA 318
Query: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSL 275
L E +Q+ A L++LFL G F+ + E+ RT + NT+FR NSL
Sbjct: 319 SAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSL 375
Query: 276 ASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAE 335
ASK ++ +K+AGM YLH L P I ++ + K E+DP K++ + E
Sbjct: 376 ASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK--------------DGE 421
Query: 336 VLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVT 395
LE + + LR ++ + A++ S +CP V+ F L +RF +V + AV+
Sbjct: 422 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDDPDVRYTAVS 479
Query: 396 SFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRA-KEAWME 454
SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++ S + KE++M
Sbjct: 480 SFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMA 539
Query: 455 PLQPTVHQG--VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512
++ +K+F+ + +D +++ + L KEG I R +G+
Sbjct: 540 TFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMIKRAQGRKRF 593
Query: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572
+FKK +F LT ++ K+ + I + NI A EK+EE+SF ++ QVI +
Sbjct: 594 GMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPER 653
Query: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632
A Y+Q E W+ L KVS N L YHP + W CC + G
Sbjct: 654 A-----LYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPG 708
Query: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIY 659
C + D +D D E + IY
Sbjct: 709 CSPCTGGLPANIQLD-IDGDRETERIY 734
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 97 TSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
T IV+KS P + E F E+ + L +D D+ R+ +GKV I + L+
Sbjct: 50 TKIVEKSLCPFYGEDFYCEIPR-SFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNR 108
Query: 157 EGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRD 188
+ WF+LQ + S G + LE+RL +
Sbjct: 109 DTWFQLQHVDADSEVQ-----GKVHLELRLSE 135
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 132 bits (333), Expect = 9e-31
Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%)
Query: 49 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359
Query: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 155
W E FEF + ++ V + D+ + N+++G V I + Q
Sbjct: 360 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 410
Query: 156 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 214
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 411 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 462
Query: 215 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 273
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N
Sbjct: 463 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 519
Query: 274 SLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 333
++A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS
Sbjct: 520 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 565
Query: 334 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 393
+E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 566 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 622
Query: 394 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 623 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 132 bits (333), Expect = 9e-31
Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%)
Query: 49 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211
Query: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 155
W E FEF + ++ V + D+ + N+++G V I + Q
Sbjct: 212 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 262
Query: 156 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 214
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 263 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 314
Query: 215 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 273
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N
Sbjct: 315 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 371
Query: 274 SLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 333
++A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS
Sbjct: 372 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 417
Query: 334 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 393
+E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 418 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 474
Query: 394 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 475 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 118 bits (295), Expect = 2e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143
Query: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200
Query: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252
Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312
Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357
Query: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413
Query: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471
Query: 475 VDIEE-------KDELDLQRTLS 490
+ E + +DL R LS
Sbjct: 472 SNPETLSNTAGFEGYIDLGRELS 494
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 118 bits (295), Expect = 2e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239
Query: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296
Query: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348
Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408
Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453
Query: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509
Query: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567
Query: 475 VDIEE-------KDELDLQRTLS 490
+ E + +DL R LS
Sbjct: 568 SNPETLSNTAGFEGYIDLGRELS 590
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
sapiens]
Length = 1343
Score = 115 bits (289), Expect = 1e-25
Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)
Query: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
L+ ++EAR+L PK R D + R + R S W E FEF
Sbjct: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318
Query: 120 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 168
A+ AL + + D D + D ++G V + V L E W+ +
Sbjct: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378
Query: 169 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 218
S +G +++L+ R + ++LP Y+ + + ++ L
Sbjct: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431
Query: 219 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 277
++E + + +++VA+ L+ + G AKDFL + E+ R E L FR N+LA+
Sbjct: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491
Query: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337
K++E ++++ G +YL +G I ++E ++ E+DP K C+ A L
Sbjct: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536
Query: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397
+ LR L + S P ++ F R ER E++ +++
Sbjct: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592
Query: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 447
L LRF PAIMSP LF L + + D +TSRTL L+AK +QN+ N S+
Sbjct: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 105 bits (263), Expect = 1e-22
Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)
Query: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752
Query: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294
A+ LL++FL + L L L E+S E TLFR+ +LAS +E ++K Q++H
Sbjct: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812
Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854
Query: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912
Query: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P + H+ +
Sbjct: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970
Query: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490
L + + +L D E DL R L+
Sbjct: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 105 bits (263), Expect = 1e-22
Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)
Query: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575
Query: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294
A+ LL++FL + L L L E+S E TLFR+ +LAS +E ++K Q++H
Sbjct: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635
Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677
Query: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735
Query: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P + H+ +
Sbjct: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793
Query: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490
L + + +L D E DL R L+
Sbjct: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)
Query: 179 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 238
+L+ +R R VLPS Y+ L L +L +E + ++++A +
Sbjct: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466
Query: 239 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHGVLG 297
+++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG
Sbjct: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526
Query: 298 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 357
++ ++ + E+DPSK C P+ +A LR + +
Sbjct: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571
Query: 358 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 417
S PA + F +ER G++ + + F LR PAI++P LF L
Sbjct: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627
Query: 418 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITK--LV 475
H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V
Sbjct: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685
Query: 476 DIE 478
D++
Sbjct: 686 DVD 688
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 84.0 bits (206), Expect = 5e-16
Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%)
Query: 67 VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 121
V +A++L P D NG SDP+V+++ K +++ T +K S P WNETF F+L+E
Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236
Query: 122 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162
+ L VE WDWDL SRNDF+G + + L+ +GWF+L
Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 84.0 bits (206), Expect = 5e-16
Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%)
Query: 67 VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 121
V +A++L P D NG SDP+V+++ K +++ T +K S P WNETF F+L+E
Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236
Query: 122 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162
+ L VE WDWDL SRNDF+G + + L+ +GWF+L
Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 81.3 bits (199), Expect = 3e-15
Identities = 49/119 (41%), Positives = 68/119 (57%), Gaps = 8/119 (6%)
Query: 50 LRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR-----ETSIVKKSC 104
L+LE+ A + +V EAR+L P D NG SDP+V+++ R +T VK +
Sbjct: 161 LQLEI-RAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATL 219
Query: 105 YPRWNETFEFELQEGAMEA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162
P WNETF F L+ G +E L VE WDWD SRNDF+G + V L + +GW++L
Sbjct: 220 NPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL-LKAPVDGWYKL 277
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 79.0 bits (193), Expect = 1e-14
Identities = 44/126 (34%), Positives = 73/126 (57%), Gaps = 11/126 (8%)
Query: 43 EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-T 97
E +G I+L+ EV +L +V +A++L P D NG SDP+V+++ K +++ T
Sbjct: 157 EKRGRIYLKAEVADE----KLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKT 212
Query: 98 SIVKKSCYPRWNETFEFELQEGAMEA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
++ + P+WNE+F F+L+ + L VE WDWD +RNDF+G + V L +
Sbjct: 213 KTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL-MKMPA 271
Query: 157 EGWFRL 162
GW++L
Sbjct: 272 SGWYKL 277
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 77.0 bits (188), Expect = 6e-14
Identities = 71/256 (27%), Positives = 114/256 (44%), Gaps = 27/256 (10%)
Query: 189 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 248
ETVL + ++ LV L+ +G QG + + ++A L+ LF + L
Sbjct: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
Query: 249 KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 308
L +F E+ TLFR NSLASK + KV G YL +L P++ V
Sbjct: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313
Query: 309 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 364
+ E+DP+++E +E LE++ + L A+ S P
Sbjct: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359
Query: 365 VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 424
+R+ L++ V +RFP AV S + LRF +PAI+SP + ++ R
Sbjct: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414
Query: 425 SRTLLLLAKAVQNVGN 440
R L L++K +Q++ N
Sbjct: 1415 ERGLKLMSKILQSIAN 1430
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 74.7 bits (182), Expect = 3e-13
Identities = 50/153 (32%), Positives = 79/153 (51%), Gaps = 28/153 (18%)
Query: 44 VQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV--------------- 88
+ GEI L++ G L +L+AR+L P+D NG SDPFV+V
Sbjct: 4694 ITGEIQLQINYDLG----NLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNA 4749
Query: 89 --RYKGRTRETSIVKKSCYPRWNETFEFE---LQEGAMEALCVEAWDWDLVSRNDFLGKV 143
YK RT+ V+KS P WN+T ++ +++ + L V WD+D S NDFLG+V
Sbjct: 4750 SAEYKRRTKH---VQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEV 4806
Query: 144 VIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
+ID+ + W+ L+ +Q++S H + +
Sbjct: 4807 LIDLSSTSHLDNTPRWYPLK-EQTESIDHGKSH 4838
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 74.7 bits (182), Expect = 3e-13
Identities = 50/153 (32%), Positives = 79/153 (51%), Gaps = 28/153 (18%)
Query: 44 VQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV--------------- 88
+ GEI L++ G L +L+AR+L P+D NG SDPFV+V
Sbjct: 4694 ITGEIQLQINYDLG----NLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNA 4749
Query: 89 --RYKGRTRETSIVKKSCYPRWNETFEFE---LQEGAMEALCVEAWDWDLVSRNDFLGKV 143
YK RT+ V+KS P WN+T ++ +++ + L V WD+D S NDFLG+V
Sbjct: 4750 SAEYKRRTKH---VQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEV 4806
Query: 144 VIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
+ID+ + W+ L+ +Q++S H + +
Sbjct: 4807 LIDLSSTSHLDNTPRWYPLK-EQTESIDHGKSH 4838
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 71.6 bits (174), Expect = 2e-12
Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 47 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 106
++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P
Sbjct: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294
Query: 107 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 150
+W E F+F L E + + AWD D R+DF+G+ +D+ L
Sbjct: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
Score = 50.8 bits (120), Expect = 4e-06
Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 62 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 120
+L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L +
Sbjct: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG +
Sbjct: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154
Query: 181 QLEVRL-------RDETVL 192
L V L RD T+L
Sbjct: 155 LLSVILTPKEGESRDVTML 173
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 122
L+ V+ A L D G SDPF V T V K+ P WN+ F F +++
Sbjct: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHS 465
Query: 123 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
L V +D D DFLGKV I + ++ +Q+
Sbjct: 466 VLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK 499
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 71.6 bits (174), Expect = 2e-12
Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 47 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 106
++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P
Sbjct: 460 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 515
Query: 107 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 150
+W E F+F L E + + AWD D R+DF+G+ +D+ L
Sbjct: 516 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 559
Score = 50.8 bits (120), Expect = 4e-06
Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 62 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 120
+L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L +
Sbjct: 262 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 320
Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG +
Sbjct: 321 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 375
Query: 181 QLEVRL-------RDETVL 192
L V L RD T+L
Sbjct: 376 LLSVILTPKEGESRDVTML 394
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 122
L+ V+ A L D G SDPF V T V K+ P WN+ F F +++
Sbjct: 628 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHS 686
Query: 123 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
L V +D D DFLGKV I + ++ +Q+
Sbjct: 687 VLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK 720
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 70.5 bits (171), Expect = 5e-12
Identities = 42/116 (36%), Positives = 66/116 (56%), Gaps = 8/116 (6%)
Query: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE---L 116
L +++A++L KD +GTSDPFV++ K ET + +K+ P WNETF FE
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211
Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQP--DQSKSR 170
++ L ++ D+D SRND +G+V I + ++ + Q + W L+P D S SR
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSR 267
Score = 62.0 bits (149), Expect = 2e-09
Identities = 45/153 (29%), Positives = 81/153 (52%), Gaps = 12/153 (7%)
Query: 1 MDEDALSRDDVIGKVCLTRDTI-ASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGAR 59
+D D SR+D IG+V + + + + + F W L +GE+ L L P A
Sbjct: 224 LDYDRFSRNDPIGEVSIPLNKVDLTQMQTF--WKDLKPCSDGSGSRGELLLSLCYNPSAN 281
Query: 60 ACRLRCSVLEARDLAPKDRNGTSDPFVRV--RYKGR---TRETSIVKKSCYPRWNETFEF 114
+ + ++++AR+L D GTSDP+V+V YK + ++T +K++ P +NE+F F
Sbjct: 282 S--IIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAF 339
Query: 115 ELQEGAME--ALCVEAWDWDLVSRNDFLGKVVI 145
++ + + + D D +SRND +GK+ +
Sbjct: 340 DIPTEKLRETTIIITVMDKDKLSRNDVIGKIYL 372
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 68.6 bits (166), Expect = 2e-11
Identities = 68/269 (25%), Positives = 115/269 (42%), Gaps = 32/269 (11%)
Query: 189 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 248
ETVL + ++ LV L+ +G QG + + ++A L+ LF + L
Sbjct: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
Query: 249 KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 308
L +F E+ TLFR NSLASK + KV G YL +L P++ V
Sbjct: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313
Query: 309 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 364
+ E+DP+++E + + + +L+ + + A + + + C
Sbjct: 1314 WQHVSFEVDPTRLEPSE------SLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHC 1367
Query: 365 VVRATFRQLFRR-------------VRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPK 411
+ +AT L + V +RFP AV S + LRF +PAI+SP
Sbjct: 1368 LYQATCHSLLNKATVKEKKENKKSVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPY 1422
Query: 412 LFHLRERHADARTSRTLLLLAKAVQNVGN 440
+ ++ R R L L++K +Q++ N
Sbjct: 1423 EAGILDKKPPPRIERGLKLMSKILQSIAN 1451
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 64.3 bits (155), Expect = 4e-10
Identities = 58/204 (28%), Positives = 85/204 (41%), Gaps = 33/204 (16%)
Query: 2 DEDALSRDDVIGKV-----------------CLTRDTIASHPKGFSGW-----AHLTEVD 39
DED LS ++ IG++ CL R + P S +L E++
Sbjct: 181 DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE 240
Query: 40 PDEEVQGEIHLR----LEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY----- 90
E+ QG + R L + +R L +L LA D NG SDP+V+
Sbjct: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300
Query: 91 KGRTRETSIVKKSCYPRWNETF--EFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148
K +T + KK+ P +NE F E EL A + L V WD+D+ NDF+G V +
Sbjct: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360
Query: 149 RLRVVQQEEGWFRLQPDQSKSRRH 172
++ QPD + R H
Sbjct: 361 ARGEARKHWSDCLQQPDAALERWH 384
Score = 55.8 bits (133), Expect = 1e-07
Identities = 30/105 (28%), Positives = 55/105 (52%), Gaps = 8/105 (7%)
Query: 60 ACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIVKKSCYPRWNETFEF 114
+C L CS+L A+ L P D NG +DP+V++ K +T + + P WNE +
Sbjct: 103 SCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTY 162
Query: 115 E---LQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
+ + L + D D +S N+F+G++ + ++RL+ Q++
Sbjct: 163 SGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKK 207
>gi|40068038 B/K protein [Homo sapiens]
Length = 474
Score = 64.3 bits (155), Expect = 4e-10
Identities = 48/152 (31%), Positives = 78/152 (51%), Gaps = 10/152 (6%)
Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
+D D SR VIGKV + + KG W L +E GE+ L L P A
Sbjct: 279 VDFDKFSRHCVIGKVSVPLCEV-DLVKGGHWWKALIPSSQNEVELGELLLSLNYLPSAG- 336
Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKG-----RTRETSIVKKSCYPRWNETFEFE 115
RL V+ A+ L D + SDPFV+++ +T++TS ++ + P +NE+F F+
Sbjct: 337 -RLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFK 395
Query: 116 LQEGAME--ALCVEAWDWDLVSRNDFLGKVVI 145
+ + +E +L + ++ S NDF+G++VI
Sbjct: 396 VPQEELENASLVFTVFGHNMKSSNDFIGRIVI 427
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/134 (26%), Positives = 64/134 (47%), Gaps = 17/134 (12%)
Query: 63 LRCSVLEARDLAPK-DRNGT------SDPFVRVRY---KGRTRETSIVKKSCYPRWNETF 112
L V+EARDL P +G+ S+P+V++ + +++T + +K+ P + E +
Sbjct: 201 LTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERY 260
Query: 113 EFELQ--EGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSR 170
FE+ E L + D+D SR+ +GKV + + + +V+ W L P
Sbjct: 261 TFEIPFLEAQRRTLLLTVVDFDKFSRHCVIGKVSVPLCEVDLVKGGHWWKALIPSS---- 316
Query: 171 RHDEGNLGSLQLEV 184
+E LG L L +
Sbjct: 317 -QNEVELGELLLSL 329
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,385,294
Number of Sequences: 37866
Number of extensions: 1284213
Number of successful extensions: 3901
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 3396
Number of HSP's gapped (non-prelim): 375
length of query: 731
length of database: 18,247,518
effective HSP length: 110
effective length of query: 621
effective length of database: 14,082,258
effective search space: 8745082218
effective search space used: 8745082218
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.