Search of human proteins with 116256453

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
sapiens]
         (2524 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...  5115   0.0  
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...  4948   0.0  
gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens]           1498   0.0  
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  112   4e-24
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   112   4e-24
gi|209977080 REST corepressor 3 isoform a [Homo sapiens]              112   5e-24
gi|8922733 REST corepressor 3 isoform d [Homo sapiens]                112   5e-24
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  106   3e-22
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  106   3e-22
gi|7661892 REST corepressor 1 [Homo sapiens]                          105   6e-22
gi|163965366 nascent polypeptide-associated complex alpha subuni...   101   1e-20
gi|209977084 REST corepressor 3 isoform c [Homo sapiens]              100   1e-20
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]    100   3e-20
gi|27734799 REST corepressor 2 [Homo sapiens]                         100   3e-20
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          92   8e-18
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          92   8e-18
gi|210032580 SET domain containing 1B [Homo sapiens]                   90   2e-17
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    88   9e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    88   1e-16
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           86   4e-16
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             86   6e-16
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    84   1e-15
gi|150170670 piccolo isoform 2 [Homo sapiens]                          83   4e-15
gi|150378539 piccolo isoform 1 [Homo sapiens]                          83   4e-15
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    82   7e-15
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       82   7e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    80   2e-14
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          80   3e-14
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    78   1e-13
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    78   1e-13

>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sapiens]
          Length = 2524

 Score = 5115 bits (13269), Expect = 0.0
 Identities = 2524/2524 (100%), Positives = 2524/2524 (100%)

Query: 1    MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60
            MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ
Sbjct: 1    MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60

Query: 61   PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120
            PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP
Sbjct: 61   PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120

Query: 121  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180
            SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
Sbjct: 121  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180

Query: 181  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240
            REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA
Sbjct: 181  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240

Query: 241  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300
            AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ
Sbjct: 241  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300

Query: 301  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360
            RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG
Sbjct: 301  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360

Query: 361  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420
            LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM
Sbjct: 361  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420

Query: 421  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480
            KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK
Sbjct: 421  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480

Query: 481  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540
            SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN
Sbjct: 481  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540

Query: 541  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600
            DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ
Sbjct: 541  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600

Query: 601  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660
            SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ
Sbjct: 601  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660

Query: 661  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720
            NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE
Sbjct: 661  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720

Query: 721  AEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP 780
            AEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP
Sbjct: 721  AEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP 780

Query: 781  GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 840
            GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG
Sbjct: 781  GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 840

Query: 841  EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 900
            EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS
Sbjct: 841  EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 900

Query: 901  GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 960
            GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP
Sbjct: 901  GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 960

Query: 961  LDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRG 1020
            LDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRG
Sbjct: 961  LDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRG 1020

Query: 1021 KSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPS 1080
            KSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPS
Sbjct: 1021 KSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPS 1080

Query: 1081 AFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQL 1140
            AFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQL
Sbjct: 1081 AFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQL 1140

Query: 1141 HVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1200
            HVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS
Sbjct: 1141 HVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1200

Query: 1201 VLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPS 1260
            VLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPS
Sbjct: 1201 VLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPS 1260

Query: 1261 RLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDM 1320
            RLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDM
Sbjct: 1261 RLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDM 1320

Query: 1321 MEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRR 1380
            MEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRR
Sbjct: 1321 MEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRR 1380

Query: 1381 EAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREEL 1440
            EAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREEL
Sbjct: 1381 EAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREEL 1440

Query: 1441 RHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVM 1500
            RHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVM
Sbjct: 1441 RHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVM 1500

Query: 1501 ADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGH 1560
            ADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGH
Sbjct: 1501 ADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGH 1560

Query: 1561 LPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEH 1620
            LPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEH
Sbjct: 1561 LPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEH 1620

Query: 1621 LLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGY 1680
            LLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGY
Sbjct: 1621 LLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGY 1680

Query: 1681 PDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIID 1740
            PDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIID
Sbjct: 1681 PDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIID 1740

Query: 1741 LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSS 1800
            LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSS
Sbjct: 1741 LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSS 1800

Query: 1801 SERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1860
            SERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS
Sbjct: 1801 SERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1860

Query: 1861 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1920
            HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF
Sbjct: 1861 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1920

Query: 1921 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPAS 1980
            PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPAS
Sbjct: 1921 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPAS 1980

Query: 1981 SPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSI 2040
            SPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSI
Sbjct: 1981 SPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSI 2040

Query: 2041 QELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGP 2100
            QELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGP
Sbjct: 2041 QELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGP 2100

Query: 2101 VKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQ 2160
            VKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQ
Sbjct: 2101 VKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQ 2160

Query: 2161 QLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTS 2220
            QLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTS
Sbjct: 2161 QLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTS 2220

Query: 2221 VLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFS 2280
            VLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFS
Sbjct: 2221 VLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFS 2280

Query: 2281 KLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQ 2340
            KLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQ
Sbjct: 2281 KLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQ 2340

Query: 2341 EHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHT 2400
            EHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHT
Sbjct: 2341 EHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHT 2400

Query: 2401 LTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDR 2460
            LTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDR
Sbjct: 2401 LTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDR 2460

Query: 2461 PSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETL 2520
            PSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETL
Sbjct: 2461 PSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETL 2520

Query: 2521 SDSE 2524
            SDSE
Sbjct: 2521 SDSE 2524


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sapiens]
          Length = 2462

 Score = 4948 bits (12835), Expect = 0.0
 Identities = 2461/2525 (97%), Positives = 2461/2525 (97%), Gaps = 64/2525 (2%)

Query: 1    MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60
            MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ
Sbjct: 1    MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60

Query: 61   PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120
            PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP
Sbjct: 61   PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120

Query: 121  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180
            SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
Sbjct: 121  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180

Query: 181  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240
            REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA
Sbjct: 181  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240

Query: 241  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300
            AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ
Sbjct: 241  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300

Query: 301  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360
            RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG
Sbjct: 301  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360

Query: 361  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420
            LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM
Sbjct: 361  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420

Query: 421  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480
            KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK
Sbjct: 421  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480

Query: 481  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540
            SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN
Sbjct: 481  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540

Query: 541  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600
            DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ
Sbjct: 541  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600

Query: 601  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660
            SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ
Sbjct: 601  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660

Query: 661  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720
            NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE
Sbjct: 661  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720

Query: 721  AEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP 780
            AEA                 TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP
Sbjct: 721  AEA-----------------TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP 763

Query: 781  GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 840
            GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG
Sbjct: 764  GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 823

Query: 841  EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 900
            EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS
Sbjct: 824  EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 883

Query: 901  GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 960
            GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP
Sbjct: 884  GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 943

Query: 961  LDLKQLKQRAAAIPPI-VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1019
            LDLKQLKQRAAAIPPI VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR
Sbjct: 944  LDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1003

Query: 1020 GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP 1079
            GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP
Sbjct: 1004 GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP 1063

Query: 1080 SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ 1139
            SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ
Sbjct: 1064 SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ 1123

Query: 1140 LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA 1199
            LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA
Sbjct: 1124 LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA 1183

Query: 1200 SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP 1259
            SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP
Sbjct: 1184 SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP 1243

Query: 1260 SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD 1319
            SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD
Sbjct: 1244 SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD 1303

Query: 1320 MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR 1379
            MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR
Sbjct: 1304 MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR 1363

Query: 1380 REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE 1439
            REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE
Sbjct: 1364 REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE 1423

Query: 1440 LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV 1499
            LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV
Sbjct: 1424 LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV 1483

Query: 1500 MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG 1559
            MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG
Sbjct: 1484 MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG 1543

Query: 1560 HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE 1619
            HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE
Sbjct: 1544 HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE 1603

Query: 1620 HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG 1679
            HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG
Sbjct: 1604 HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG 1663

Query: 1680 YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII 1739
            YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII
Sbjct: 1664 YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII 1723

Query: 1740 DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS 1799
            DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS
Sbjct: 1724 DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS 1783

Query: 1800 SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1859
            SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA
Sbjct: 1784 SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1843

Query: 1860 SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT 1919
            SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT
Sbjct: 1844 SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT 1903

Query: 1920 FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA 1979
            FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA
Sbjct: 1904 FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA 1963

Query: 1980 SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS 2039
            SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS
Sbjct: 1964 SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS 2023

Query: 2040 IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG 2099
            IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG
Sbjct: 2024 IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG 2083

Query: 2100 PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP 2159
            PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP
Sbjct: 2084 PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP 2143

Query: 2160 QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT 2219
            QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT
Sbjct: 2144 QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT 2203

Query: 2220 SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF 2279
            SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF
Sbjct: 2204 SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF 2263

Query: 2280 SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV 2339
            SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV
Sbjct: 2264 SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV 2323

Query: 2340 QEHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDH 2399
            QEHASTNMGLEAIIRKALM                                         
Sbjct: 2324 QEHASTNMGLEAIIRKALM----------------------------------------- 2342

Query: 2400 TLTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED 2459
                 GGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED
Sbjct: 2343 -----GGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED 2397

Query: 2460 RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET 2519
            RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET
Sbjct: 2398 RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET 2457

Query: 2520 LSDSE 2524
            LSDSE
Sbjct: 2458 LSDSE 2462


>gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens]
          Length = 2440

 Score = 1498 bits (3877), Expect = 0.0
 Identities = 1086/2660 (40%), Positives = 1442/2660 (54%), Gaps = 357/2660 (13%)

Query: 1    MSGSTQPVAQTWRATEP-RYPPHSLSYPVQIARTHTDVGLLEYQ--HHSRDYASHLSPGS 57
            MS S  P  Q   +TE  RYPPHS+ Y     R   +  + +Y+  H     AS L    
Sbjct: 1    MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQ 60

Query: 58   IIQPQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPD-- 115
              Q  RRRPSLLSEF PG++R QE   R     + P     + + +ESKRPRLE + D  
Sbjct: 61   QQQQLRRRPSLLSEFHPGSDRPQER--RTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSH 118

Query: 116  ---------PLLRPSPLLATGQPAGSEDLTKDRSLTGKLE-PVSPPSPPHTDPELELVPP 165
                     PL+ P P    G  A S D  KD +  GK E P SP S      +    P 
Sbjct: 119  FQRVSAAVLPLVHPLP---EGLRA-SADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPS 174

Query: 166  RLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRS 225
            +LSKEELIQ+MDRVDREI  VEQQI KLKKKQQQLEEEAAKPPEPEKPVSPPP+E KHRS
Sbjct: 175  KLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRS 234

Query: 226  LVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFK 285
            +VQIIYDENRKKAE AH+I EGLGP+VELPLYNQPSDT+ YHENIK NQ MRKKLIL+FK
Sbjct: 235  IVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIKTNQVMRKKLILFFK 294

Query: 286  RRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRE 345
            RRNHARKQ EQK CQRYDQLMEAWEKKV+RIENNPRR+AKESK REYYEKQFPEIRKQRE
Sbjct: 295  RRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQRE 354

Query: 346  LQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQ 405
             QER Q RVGQRG+GLS + ARSEHE+SEIIDGLSEQEN EKQMRQL+VIPPM++DA+Q+
Sbjct: 355  QQERFQ-RVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQR 413

Query: 406  RIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAE 465
            R+KFINMNGLM DPMKVYKDRQ MN+W++ EKE F++KF+QHPKNFGLIAS+LERK+V +
Sbjct: 414  RVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPD 473

Query: 466  CVLYYYLTKKNENYKSLVRRSY-RRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKE 524
            CVLYYYLTKKNENYK+LVRR+Y +RRG++QQ  +  Q+++ +++++   ++ + EK E+E
Sbjct: 474  CVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEE--DKAEKTEKKEEE 531

Query: 525  KEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITR 584
            K+ E EK+E++   EN KE   K+K D T+ E+ +E+E    +GRKTANSQGRRKGRITR
Sbjct: 532  KKDEEEKDEKEDSKENTKE---KDKIDGTA-EETEEREQATPRGRKTANSQGRRKGRITR 587

Query: 585  SMANEANSEEAITPQQS----------AELASMELNESSRWTEEEMETAKKGLLEHGRNW 634
            SM NEA +  A     +           E  S E  E+SRWTEEEME AKKGL+EHGRNW
Sbjct: 588  SMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLVEHGRNW 647

Query: 635  SAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEA 694
            +AIA+MVG+K+ +QCKNFYFNYK+R NLD +LQQHK K  ++    R   +  + AS  +
Sbjct: 648  AAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVS 707

Query: 695  AFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSP 754
            A     EDE++EAS    NEEE  E++E       E  +     P    +  +TE  P+ 
Sbjct: 708  A----QEDEDIEAS----NEEENPEDSEV------EAVKPSEDSPENATSRGNTE--PAV 751

Query: 755  HTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPS 814
              E   +T    P    +L        P T P ED    T+    +++  A T       
Sbjct: 752  ELEPTTET---APSTSPSLAV------PSTKPAEDESVETQ---VNDSISAET------- 792

Query: 815  PSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGP 874
             +    V  +E   EE +   P        PPA +  +VD    E  V      + E   
Sbjct: 793  -AEQMDVDQQEHSAEEGSVCDP--------PPATKADSVD---VEVRVPENHASKVEGDN 840

Query: 875  AKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDK 934
             K +D + A    E       ++    +   A+      D+DSSATCSADE  + +G  +
Sbjct: 841  TKERDLDRASEKVE----PRDEDLVVAQQINAQRPEPQSDNDSSATCSADE--DVDGEPE 894

Query: 935  NRLLSP---RPSLLTPTGDPRANASPQK--PLDLKQLKQRAAAIPPIVTKVHEPPREDAA 989
             + + P   +PSLL PTG     +SP K  PLDL QL+ RAA IPP+V+           
Sbjct: 895  RQRMFPMDSKPSLLNPTGSILV-SSPLKPNPLDLPQLQHRAAVIPPMVS---------CT 944

Query: 990  PTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKL 1049
            P    P   P       +        S+   + R      D E                 
Sbjct: 945  PCN-IPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQIDLECRS-------------- 989

Query: 1050 PGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTI 1109
                PC TS    P    EV++ +PH       +  P G  LP     T RP  P PP I
Sbjct: 990  -STSPCGTS--KSPNREWEVLQPAPH----QVITNLPEGVRLP-----TTRPTRPPPPLI 1037

Query: 1110 SNPPPLISSAKHPSVLERQIGAISQG-----MSVQLHVPYSEHAKAP-VGPVTMGLPLPM 1163
             +    ++S K   ++    G+ISQG     ++      Y++    P VG +++GLP   
Sbjct: 1038 PSSKTTVASEKPSFIMG---GSISQGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQ 1094

Query: 1164 DPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTR 1223
            +  K A    +KQE+ SPR Q   PE L V  AQ   V+RGTA G++  GSIT+G P+++
Sbjct: 1095 ESAKSATLPYIKQEEFSPRSQNSQPEGLLV-RAQHEGVVRGTA-GAIQEGSITRGTPTSK 1152

Query: 1224 VPSDSAITYRGSITHGTPA--------DVLYKGTITRIIGEDSPSRLDRGREDSLPKGHV 1275
            +  +S  + RGSIT GTPA        + L KG+I+R+  EDS    ++GRE++  KGHV
Sbjct: 1153 ISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRMPIEDSSP--EKGREEAASKGHV 1210

Query: 1276 IYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAIS----- 1330
            IYEGK GH+LSY+   +       +G  S    HE +  KR+Y+ +EG + + +S     
Sbjct: 1211 IYEGKSGHILSYDNIKNA-----REGTRSPRTAHEISL-KRSYESVEGNIKQGMSMRESP 1264

Query: 1331 -SASIEGLMGRAIPPERHSPH-HLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKRE 1388
             SA +EGL+ RA+P  R SPH  LKE+  + GSI QG PR+  E+ ED L +  K +KRE
Sbjct: 1265 VSAPLEGLICRALP--RGSPHSDLKERTVLSGSIMQGTPRATTESFEDGL-KYPKQIKRE 1321

Query: 1389 GTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREEL-----RHT 1443
                  PP R    A         K KP ++G + T+KE GRSIHEIPR+++     R T
Sbjct: 1322 S-----PPIRAFEGAI-------TKGKP-YDG-ITTIKEMGRSIHEIPRQDILTQESRKT 1367

Query: 1444 PELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMAD- 1502
            PE+  + RP+ EGSI+QGTP+K+D   S   + KH+V+SLI  P +    + PL+++ + 
Sbjct: 1368 PEVVQSTRPIIEGSISQGTPIKFDNN-SGQSAIKHNVKSLITGPSKLSRGMPPLEIVPEN 1426

Query: 1503 ARALERACYE-----ESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGA-- 1555
             + +ER  YE     E+++SR  +  SSG S+ R     + E  K + SP  Y+D  A  
Sbjct: 1427 IKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRST---LHEAPKAQLSPGIYDDTSARR 1483

Query: 1556 ---PFAGHLPRGSPVTTREPTPRLQEGSLSSSKA-SQDRKLTSTPRE----IAKSPHSTV 1607
                +   + RGSP+       R  + ++SS+K+ + +RK T TP +     AKSP   V
Sbjct: 1484 TPVSYQNTMSRGSPMMN-----RTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGV 1538

Query: 1608 PEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLD-AAAAYYLPRHLAPNP 1666
                 H  SP++   RG +  ++YRSH+P   DP ++P    LD AAAAY   R L+P P
Sbjct: 1539 DPVVSH--SPFDPHHRGSTAGEVYRSHLPTHLDP-AMPFHRALDPAAAAYLFQRQLSPTP 1595

Query: 1667 TYPHLYPPYLIRGYPDTAALEN-RQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRES 1725
             YP  Y  Y         A+EN RQTI+NDYITSQQM  N       R D+ RGLSPRE 
Sbjct: 1596 GYPSQYQLY---------AMENTRQTILNDYITSQQMQVNL------RPDVARGLSPREQ 1640

Query: 1726 SLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSR-HSSSPL 1784
             L L Y A  RGIIDL+ +P   +LVP   GT    MDR+ Y+P     F  R ++S+ +
Sbjct: 1641 PLGLPYPA-TRGIIDLTNMPP-TILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASM 1698

Query: 1785 SPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGS 1844
            SPG PTHL      +S+ERER+R+RE++R+RER   I  +++ +      RPG+EQ    
Sbjct: 1699 SPGHPTHL---AAAASAEREREREREKERERER---IAAASSDL----YLRPGSEQ---- 1744

Query: 1845 SGSSGGGGGSSSRPASHSHAHQHSPISPRTQDA-LQQRPSVLHNTGMKGIITAVEPSTPT 1903
                        RP SH +    SP S RTQ+  LQQRPSV   T    +IT ++P+   
Sbjct: 1745 ----------PGRPGSHGYVRSPSP-SVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQL 1793

Query: 1904 VLRSTSTSSPV----RPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPR-------- 1951
             +       P      PA+ +  A    L   +D         V   KE+          
Sbjct: 1794 RIMPLPAGGPSISQGLPASRYNTAADA-LAALVDAAASAPQMDVSKTKESKHEAARLEEN 1852

Query: 1952 -----VARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLV-----------PPV 1995
                  A  E+ + +     + K   +     ++ PS   +P   V           PP 
Sbjct: 1853 LRSRSAAVSEQQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVYSEAGKDKGPPPK 1912

Query: 1996 SGHATIARTPAKN--LAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGS 2053
            S +    RT  K    A +          AS  D     +QS   S       SL  H  
Sbjct: 1913 SRYEEELRTRGKTTITAANFIDVIITRQIASDKDARERGSQSSDSS------SSLSSHRY 1966

Query: 2054 SYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL 2113
                + +E +SP SSP+   +K      E +  +  E +   +  GP         L H 
Sbjct: 1967 ETPSDAIEVISPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGP---------LHHY 2017

Query: 2114 RPLPESQPSSSPLLQTAPG--------VKGHQRVVTLAQHISEVITQDYTRHHPQQLSAP 2165
            RP    Q S SP  Q  P         V    R++TLA HI ++ITQD+ R+       P
Sbjct: 2018 RP---QQESPSPQQQLPPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVSS-QTP 2073

Query: 2166 LPAPLYSFPGASCPVLD--LRRPPSDLYLPPPD-----HGAP-ARGSPH-----SEGGKR 2212
               P  +F  +   ++   +R   S+ Y P        H  P +R SP      S G + 
Sbjct: 2074 QQPPTSTFQNSPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRP 2133

Query: 2213 SPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNT 2272
               P ++ V     +  EP+SPP+      H +     LL + G +    R  ++SPG+ 
Sbjct: 2134 GKSPERSHV---SSEPYEPISPPQ--VPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSI 2188

Query: 2273 SQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLM 2332
            S  P+FF+KL E+ S MVKSKKQEI +KLN+    + +   +QPGTEIFN+PA+T +G +
Sbjct: 2189 SYLPSFFTKL-ENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGSV 2247

Query: 2333 TYRSQAVQEHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITA 2392
            + R  +  + AS N+GLE IIRKALMG +D   E   +  +   P+           +T+
Sbjct: 2248 SSRGHSFADPAS-NLGLEDIIRKALMGSFDDKVEDHGVVMS--QPMGVVPGTANTSVVTS 2304

Query: 2393 ADGRSDHTLTSPGGGG--KAKVSGRPSSRKAKSPAP--GLASGDRPPSVSSVHSEGDCNR 2448
             + R +    SP  GG  K K+  + +SRK+KSP P  G    +RP SVSSVHSEGD +R
Sbjct: 2305 GETRREEGDPSPHSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHR 2364

Query: 2449 RTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSG-PLAGPH---HA 2504
            +TP     WEDRPSS GST FPYNPL MR+   + ++PP P   A S    A PH     
Sbjct: 2365 QTP--GWAWEDRPSSTGSTQFPYNPLTMRM---LSSTPPTPIACAPSAVNQAAPHQQNRI 2419

Query: 2505 WDEEPKPLLCSQYETLSDSE 2524
            W+ EP PLL +QYETLSDS+
Sbjct: 2420 WEREPAPLLSAQYETLSDSD 2439


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  112 bits (281), Expect = 4e-24
 Identities = 168/732 (22%), Positives = 249/732 (34%), Gaps = 99/732 (13%)

Query: 495  QQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKE-EEKPEVENDKEDLLKEKT--- 550
            ++    + Q+          SS   K +  K   A +E ++K +V+++K++  K+K    
Sbjct: 115  EEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 174

Query: 551  -----DDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ-SAEL 604
                 +  SG DN + +        T +++     +IT   A   N   ++ P   +++ 
Sbjct: 175  PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITT--AKPINPRPSLPPNSDTSKE 232

Query: 605  ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664
             S+ +N+ +    +E  T  K     G+  +  A+   S   +  K+     K       
Sbjct: 233  TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK------- 285

Query: 665  ILQQHKLKME---KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEA 721
            +L +   K E   K       K+  P    E A+  P    +E   + +        E A
Sbjct: 286  VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP----KEPTPTTIKSAPTTPKEPA 341

Query: 722  EALHASGNEVPRGECSGPATVNNSSDTESIPSPHT--EAAKDTGQNGP------------ 767
                 S    P+ E +   T   +  T   P+P T  E A  T ++ P            
Sbjct: 342  PTTTKSAPTTPK-EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 400

Query: 768  KPPATLGADGPPPGP----PTPPPEDIPAPTEPTPASEATGAPTPP--PAPPSPSAPPPV 821
            KP  T   +  P  P    PT P E  P   EP P +    APT P  PAP +P  P P 
Sbjct: 401  KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 460

Query: 822  VPKE------EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPA 875
             PKE      ++   T    P     +  P   +E A  T K+      E +    + PA
Sbjct: 461  TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPA 520

Query: 876  KGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKN 935
                 E A  T +       KE     A T     AP  +   A  +  E          
Sbjct: 521  PTTPKEPAPTTPKKPAPTTPKE----PAPTTPKEPAPTTTKKPAPTTPKEPAPT---TPK 573

Query: 936  RLLSPRPSLLTPTGDPR-ANASPQKPLDLKQLKQRAAAIP--PIVTKVHEP--------- 983
                  P  LTPT   + A  +P+KP      ++ A   P  P  T   EP         
Sbjct: 574  ETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP-EELAPTTPEEPTPTTPEEPAPTTPKAAA 632

Query: 984  ---PREDA--APTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVF 1038
               P+E A   P +PAP  P  P    P+  AP  P  +     + PAP   K+      
Sbjct: 633  PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK------ 686

Query: 1039 FPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDT 1098
             PA    A     +P   T   P P  P+     +P  P P+      P  P P     T
Sbjct: 687  -PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT-----PKEPAPTTPKGT 740

Query: 1099 ARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMG 1158
            A      P T+  P P       P  L           +     P +    AP  P    
Sbjct: 741  A------PTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE-- 792

Query: 1159 LPLPMDPKKLAP 1170
             P P  PKK AP
Sbjct: 793  -PAPTTPKKPAP 803



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 170/727 (23%), Positives = 245/727 (33%), Gaps = 159/727 (21%)

Query: 617  EEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKE 676
            E E  T +  + E+  + S+ +    S T+ + K+   +   R+       Q KLK++  
Sbjct: 109  ESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRE------LQKKLKVKDN 162

Query: 677  RNARRKKKKAPAAASEEAAFPPVVED---------------------------------- 702
            +  R KKK  P         PPVV++                                  
Sbjct: 163  KKNRTKKKPTPK--------PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTA 214

Query: 703  -------------EEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTE 749
                         +  + + ++ N+E  VE  E    +     +    G     ++ +T+
Sbjct: 215  KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTN----KQTSTDGKEKTTSAKETQ 270

Query: 750  SI-----------------PSPHTEAA---------KDTGQNGPKPPATLGADGPPP--- 780
            SI                 P+P  E           K+     PK PA+     P P   
Sbjct: 271  SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 330

Query: 781  -GPPTPPPEDIPAPTEPTPASEATGAP--TPPPAPPSPSAPPPVVPKEEKEEETAAAP-- 835
               PT P E  P  T+  P +    AP  T  PAP +P  P P   KE     T +AP  
Sbjct: 331  KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 390

Query: 836  PVEEG------------EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAA 883
            P E              +E  P   +E    T K   P   E      + PA     + A
Sbjct: 391  PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 450

Query: 884  EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEV--DEAEGGDKNRLLSPR 941
              T +       KE  +   T   S   P++   + T SA     + A    K+   +P+
Sbjct: 451  PTTPKEPAPTTPKE-PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK 509

Query: 942  PSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEP----PREDAAPT--KPAP 995
                T T +P A  +P++P      K       P  T   EP    P+E A  T  KPAP
Sbjct: 510  EPSPTTTKEP-APTTPKEPAPTTPKK-------PAPTTPKEPAPTTPKEPAPTTTKKPAP 561

Query: 996  PAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPP---ADKEAEKPVFFPAFAAE-AQKLPG 1051
              P  P    P+  AP  P      K  +P  P   A    EKP   P    E A   P 
Sbjct: 562  TTPKEPAPTTPKETAPTTP------KKLTPTTPEKLAPTTPEKPA--PTTPEELAPTTPE 613

Query: 1052 DPPCWTSGLPFPVPPREVIKASPHAPDPSA-FSYAP--PGHPLPLGLHDTARPVLPR--- 1105
            +P   T   P P  P+     +P  P P+     AP  P  P P    +TA P  P+   
Sbjct: 614  EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA-PTTPKGTA 672

Query: 1106 PPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDP 1165
            P T+  P P  ++ K P+  E       +  S     P     K    P T   P P  P
Sbjct: 673  PTTLKEPAP--TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG-TAPTTPKEPAPTTP 729

Query: 1166 KKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPG-GSITKGIPSTRV 1224
            K+ AP         +P+G A        PT  +    +  A  +  G  S T   P+   
Sbjct: 730  KEPAP--------TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 781

Query: 1225 PSDSAIT 1231
            P ++A T
Sbjct: 782  PKETAPT 788



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 103/394 (26%), Positives = 130/394 (32%), Gaps = 65/394 (16%)

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-- 796
            P T  ++  T   P+P T  +  T    P P  T       P  P P     PAPT P  
Sbjct: 483  PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 542

Query: 797  ---TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAV 853
               T   E     T  PAP +P  P P  PK     ETA   P    ++  P   E+LA 
Sbjct: 543  PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAP 593

Query: 854  DTGKAEEP-VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAP 912
             T +   P    E      E P      E A  T + A     KE     A T     AP
Sbjct: 594  TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAP 649

Query: 913  QDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAA 972
                  A  +  E             +P+ +  T   +P A  +P+KP   K+L      
Sbjct: 650  TTPKEPAPTTPKETAPT---------TPKGTAPTTLKEP-APTTPKKPAP-KELAPTTTK 698

Query: 973  IPPIVTKVHEPPREDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPA 1029
             P   T       +  APT P   AP  P  P    P+  AP  P  +     + PAP  
Sbjct: 699  EPTSTT------CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT 752

Query: 1030 DKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGH 1089
             K+       PA    A      P   TS  P P  P+E    +P  P P+         
Sbjct: 753  PKK-------PAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------- 797

Query: 1090 PLPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1123
                       P  P P T   PPP  S    P+
Sbjct: 798  -----------PKKPAPTTPETPPPTTSEVSTPT 820



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 123/544 (22%), Positives = 171/544 (31%), Gaps = 109/544 (20%)

Query: 783  PTPPPEDIPAPTEPTPASEATGAPTP-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGE 841
            PT PP    AP  P+ AS+   + T   P PP+      V+  EE  EE +    V E +
Sbjct: 69   PTSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHS----VSENQ 123

Query: 842  EQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD-----------------AEAAE 884
            E    ++   +  T +  +  K+       +   K KD                  EA  
Sbjct: 124  ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGS 183

Query: 885  ATAEGALKA---------EKKEGGSGRATTAK----SSGAPQDSDSS------------- 918
                G  K            K   S + TTAK        P +SD+S             
Sbjct: 184  GLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTV 243

Query: 919  ---ATCSADEVDEAEGGDKNR----------------------LLSPRPSLLTPTGDPRA 953
                T + ++    +G +K                        L  P P   T T  P A
Sbjct: 244  ETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-A 302

Query: 954  NASPQKPLDLKQLKQRAAAIP--PIVTKVHEPPREDAAP----TKPAPPAPPPPQNLQPE 1007
              +P++P      K+ A+  P  P  T +   P     P    TK AP  P  P     +
Sbjct: 303  LTTPKEPTPTTP-KEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 361

Query: 1008 SDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPR 1067
              AP  P       ++ PAP   K A      P     A   P  P   T   P P  P+
Sbjct: 362  EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP-----APTTPKKPAPTTPKEPAPTTPK 416

Query: 1068 EVIKASPHAPDPSAFSYAP--PGHPLPLGLHDTA--RPVLPRPPTISNPPPLISSAKHPS 1123
            E    +P  P P+    AP  P  P P      A   P  P P T   P P  +    P+
Sbjct: 417  EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 476

Query: 1124 VLERQIGAISQGMSVQLHVPYSEHAK-APV-----GPVTMGLPLPMDPKKLAPFSGVKQE 1177
              +      ++        P     K AP       P T   P P  PK+ AP +  K  
Sbjct: 477  TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 536

Query: 1178 QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSIT 1237
              +P+  A        PT  +                 T   P+   P ++A T    +T
Sbjct: 537  PTTPKEPAPTTPKEPAPTTTKKP------------APTTPKEPAPTTPKETAPTTPKKLT 584

Query: 1238 HGTP 1241
              TP
Sbjct: 585  PTTP 588



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%)

Query: 1745 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1804
            P  P    P    P T  +     P  P P +   + +      PT   KP  T+  E  
Sbjct: 399  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 458

Query: 1805 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1860
                +E      +E S  T    + TT + AP     T++ + ++  S         P +
Sbjct: 459  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 515

Query: 1861 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1920
                   +P  P      +  P+    T  +   T  +   PT  +  + ++P  PA T 
Sbjct: 516  TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 571

Query: 1921 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1966
            P  T       L    P  + P    K AP                  PE P   T  A 
Sbjct: 572  PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 631

Query: 1967 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2021
                  +P   +  EPA  P+   EP P  P  +   T   T P     P   +P  PAP
Sbjct: 632  APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 689

Query: 2022 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2071
               A    +E T +   KP               +  +P+G  P +P          P+ 
Sbjct: 690  KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 734

Query: 2072 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2126
            T  KG  P  L+E           PK+P P +L       P      +P P +   ++P 
Sbjct: 735  TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 788

Query: 2127 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2181
                   T P         T     SEV T   T+          P  ++  P  S P L
Sbjct: 789  TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 839

Query: 2182 DLRRPPSDLYLPPPDHGAPARGSP 2205
                 P  L   P + G P   +P
Sbjct: 840  SAEPTPKALENSPKEPGVPTTKTP 863



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 84/359 (23%), Positives = 128/359 (35%), Gaps = 52/359 (14%)

Query: 732  PRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIP 791
            P+G  + P T+   + T    +P   A K+      K P +  +D P    PT P E  P
Sbjct: 737  PKG--TAPTTLKEPAPT----TPKKPAPKELAPTTTKGPTSTTSDKP---APTTPKETAP 787

Query: 792  -APTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEE----GEEQKPP 846
              P EP P +    APT P  PP P+      P   KE  T    P E       E  P 
Sbjct: 788  TTPKEPAPTTPKKPAPTTPETPP-PTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK 846

Query: 847  AAE----ELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGR 902
            A E    E  V T K     K E T  A++   + +D      T   A K  K+      
Sbjct: 847  ALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----T 900

Query: 903  ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD 962
            ATT + +     ++S  T +  +V      D         +L T T  P+   +      
Sbjct: 901  ATTTEKT-----TESKITATTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT------ 947

Query: 963  LKQLKQRAAAIPPIVTKVHE--PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRG 1020
                 ++      I+ K  E   P++ A  +K   P P  P     +  + ++P + PR 
Sbjct: 948  -----KKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRV 1002

Query: 1021 KSRSPAP-PADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1078
            +     P P    +  P   P        L       T+  P   P  ++++ +P + D
Sbjct: 1003 RKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1055



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%)

Query: 1748 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1807
            P L  P   TP T  +  +  P  P P + +  S+P +P  P     PTTT S+      
Sbjct: 301  PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 351

Query: 1808 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1867
             +E      +E +    TT  E AP     T++ + ++  S         P +       
Sbjct: 352  PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 405

Query: 1868 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1925
            +P  P      +  P+    T  +   T  EP+ PT  +  + ++P +PA T P  PA  
Sbjct: 406  TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 460

Query: 1926 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1985
             P             EP     + P    P+ P   T      K    +  EPA + +K 
Sbjct: 461  TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 503

Query: 1986 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2038
            +   P  P  +     A T  K  AP   +P  PAP       P +  +P    T+    
Sbjct: 504  APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 561

Query: 2039 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2096
            +  +    +     +  +P+ + P +P      T +K  P   EEL  +  E      P+
Sbjct: 562  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 621

Query: 2097 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2131
            +P P      A + P   P P +    +P     P
Sbjct: 622  EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 655



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%)

Query: 1565 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1624
            +P TT+EP P   +    ++        T +     K P  T P+  P P +P E     
Sbjct: 356  APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 410

Query: 1625 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1678
                       P    PT+     P     A   P+  AP       PT P    P   +
Sbjct: 411  -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 463

Query: 1679 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1737
                T   E   T   +   T+ +         A         +P+E S        P  
Sbjct: 464  EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 521

Query: 1738 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1796
                   P  P    P    P T  +     P  P P +++   +P +P  P   T K T
Sbjct: 522  -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 575

Query: 1797 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1852
              ++ ++      E+      EK     TT  E AP       P T +    +       
Sbjct: 576  APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 633

Query: 1853 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1912
             +   PA        +P  P      +  P+    T      T  + + PT L+  + ++
Sbjct: 634  NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 683

Query: 1913 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1965
            P +PA     P  T  P   T D   PT  +   P    + AP   +   P    G A  
Sbjct: 684  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 743

Query: 1966 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2018
                      K PA   L P ++    S       P +   T   TP +   P   +P  
Sbjct: 744  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 800

Query: 2019 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2078
            PAP    + P      S P + +E              P  +      S+P L+ +   P
Sbjct: 801  PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 845

Query: 2079 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2122
            K LE            PK+PG       AA  P              LR  PE   + P 
Sbjct: 846  KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 895

Query: 2123 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2182
             +    T        ++      ++   TQD T      L     AP  +    +    +
Sbjct: 896  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 955

Query: 2183 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2242
            +   P +    P D    ++ +        +P+P K            P   P+  T   
Sbjct: 956  IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 993

Query: 2243 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2300
              +    P + +      P +M S  P    TS+      + T   +    SK  E+N K
Sbjct: 994  -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1052



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 80/352 (22%), Positives = 125/352 (35%), Gaps = 56/352 (15%)

Query: 735  ECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAP 793
            E +   T   +S T   P+P T   K+T    PK PA      P P  P TPPP      
Sbjct: 760  ELAPTTTKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 817

Query: 794  TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAV 853
            T  T     T   +P  + P  SA P     E   +E             K PAA +  +
Sbjct: 818  TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEM 870

Query: 854  DTGKAEEPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG-------- 901
             T   ++  + +     E   A  K     A   E T E  + A   +  S         
Sbjct: 871  TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF 930

Query: 902  RATTAKSSG-APQDSDSSATCSADEV-----DEAEGGDK---NRLLSPRPSLLTPTGDPR 952
            + TT K++  AP+ + +  T +  E+     + A+  D+   ++  +P+P    PT  P+
Sbjct: 931  KITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQ--KPTKAPK 988

Query: 953  ANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQ 1012
               S +KP  + ++++          K    PR+    T   P   P  +  +       
Sbjct: 989  KPTSTKKPKTMPRVRK---------PKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTT 1036

Query: 1013 QPGSSPRGKSRSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1053
            +P  +P  K     P ++     E E P       VF P    +   LP  P
Sbjct: 1037 RPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1088


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  112 bits (281), Expect = 4e-24
 Identities = 168/732 (22%), Positives = 249/732 (34%), Gaps = 99/732 (13%)

Query: 495  QQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKE-EEKPEVENDKEDLLKEKT--- 550
            ++    + Q+          SS   K +  K   A +E ++K +V+++K++  K+K    
Sbjct: 156  EEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 215

Query: 551  -----DDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ-SAEL 604
                 +  SG DN + +        T +++     +IT   A   N   ++ P   +++ 
Sbjct: 216  PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITT--AKPINPRPSLPPNSDTSKE 273

Query: 605  ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664
             S+ +N+ +    +E  T  K     G+  +  A+   S   +  K+     K       
Sbjct: 274  TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK------- 326

Query: 665  ILQQHKLKME---KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEA 721
            +L +   K E   K       K+  P    E A+  P    +E   + +        E A
Sbjct: 327  VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP----KEPTPTTIKSAPTTPKEPA 382

Query: 722  EALHASGNEVPRGECSGPATVNNSSDTESIPSPHT--EAAKDTGQNGP------------ 767
                 S    P+ E +   T   +  T   P+P T  E A  T ++ P            
Sbjct: 383  PTTTKSAPTTPK-EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 441

Query: 768  KPPATLGADGPPPGP----PTPPPEDIPAPTEPTPASEATGAPTPP--PAPPSPSAPPPV 821
            KP  T   +  P  P    PT P E  P   EP P +    APT P  PAP +P  P P 
Sbjct: 442  KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 501

Query: 822  VPKE------EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPA 875
             PKE      ++   T    P     +  P   +E A  T K+      E +    + PA
Sbjct: 502  TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPA 561

Query: 876  KGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKN 935
                 E A  T +       KE     A T     AP  +   A  +  E          
Sbjct: 562  PTTPKEPAPTTPKKPAPTTPKE----PAPTTPKEPAPTTTKKPAPTTPKEPAPT---TPK 614

Query: 936  RLLSPRPSLLTPTGDPR-ANASPQKPLDLKQLKQRAAAIP--PIVTKVHEP--------- 983
                  P  LTPT   + A  +P+KP      ++ A   P  P  T   EP         
Sbjct: 615  ETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP-EELAPTTPEEPTPTTPEEPAPTTPKAAA 673

Query: 984  ---PREDA--APTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVF 1038
               P+E A   P +PAP  P  P    P+  AP  P  +     + PAP   K+      
Sbjct: 674  PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK------ 727

Query: 1039 FPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDT 1098
             PA    A     +P   T   P P  P+     +P  P P+      P  P P     T
Sbjct: 728  -PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT-----PKEPAPTTPKGT 781

Query: 1099 ARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMG 1158
            A      P T+  P P       P  L           +     P +    AP  P    
Sbjct: 782  A------PTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE-- 833

Query: 1159 LPLPMDPKKLAP 1170
             P P  PKK AP
Sbjct: 834  -PAPTTPKKPAP 844



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 170/727 (23%), Positives = 245/727 (33%), Gaps = 159/727 (21%)

Query: 617  EEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKE 676
            E E  T +  + E+  + S+ +    S T+ + K+   +   R+       Q KLK++  
Sbjct: 150  ESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRE------LQKKLKVKDN 203

Query: 677  RNARRKKKKAPAAASEEAAFPPVVED---------------------------------- 702
            +  R KKK  P         PPVV++                                  
Sbjct: 204  KKNRTKKKPTPK--------PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTA 255

Query: 703  -------------EEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTE 749
                         +  + + ++ N+E  VE  E    +     +    G     ++ +T+
Sbjct: 256  KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTN----KQTSTDGKEKTTSAKETQ 311

Query: 750  SI-----------------PSPHTEAA---------KDTGQNGPKPPATLGADGPPP--- 780
            SI                 P+P  E           K+     PK PA+     P P   
Sbjct: 312  SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 371

Query: 781  -GPPTPPPEDIPAPTEPTPASEATGAP--TPPPAPPSPSAPPPVVPKEEKEEETAAAP-- 835
               PT P E  P  T+  P +    AP  T  PAP +P  P P   KE     T +AP  
Sbjct: 372  KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 431

Query: 836  PVEEG------------EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAA 883
            P E              +E  P   +E    T K   P   E      + PA     + A
Sbjct: 432  PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 491

Query: 884  EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEV--DEAEGGDKNRLLSPR 941
              T +       KE  +   T   S   P++   + T SA     + A    K+   +P+
Sbjct: 492  PTTPKEPAPTTPKE-PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK 550

Query: 942  PSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEP----PREDAAPT--KPAP 995
                T T +P A  +P++P      K       P  T   EP    P+E A  T  KPAP
Sbjct: 551  EPSPTTTKEP-APTTPKEPAPTTPKK-------PAPTTPKEPAPTTPKEPAPTTTKKPAP 602

Query: 996  PAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPP---ADKEAEKPVFFPAFAAE-AQKLPG 1051
              P  P    P+  AP  P      K  +P  P   A    EKP   P    E A   P 
Sbjct: 603  TTPKEPAPTTPKETAPTTP------KKLTPTTPEKLAPTTPEKPA--PTTPEELAPTTPE 654

Query: 1052 DPPCWTSGLPFPVPPREVIKASPHAPDPSA-FSYAP--PGHPLPLGLHDTARPVLPR--- 1105
            +P   T   P P  P+     +P  P P+     AP  P  P P    +TA P  P+   
Sbjct: 655  EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA-PTTPKGTA 713

Query: 1106 PPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDP 1165
            P T+  P P  ++ K P+  E       +  S     P     K    P T   P P  P
Sbjct: 714  PTTLKEPAP--TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG-TAPTTPKEPAPTTP 770

Query: 1166 KKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPG-GSITKGIPSTRV 1224
            K+ AP         +P+G A        PT  +    +  A  +  G  S T   P+   
Sbjct: 771  KEPAP--------TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 822

Query: 1225 PSDSAIT 1231
            P ++A T
Sbjct: 823  PKETAPT 829



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 103/394 (26%), Positives = 130/394 (32%), Gaps = 65/394 (16%)

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-- 796
            P T  ++  T   P+P T  +  T    P P  T       P  P P     PAPT P  
Sbjct: 524  PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 583

Query: 797  ---TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAV 853
               T   E     T  PAP +P  P P  PK     ETA   P    ++  P   E+LA 
Sbjct: 584  PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAP 634

Query: 854  DTGKAEEP-VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAP 912
             T +   P    E      E P      E A  T + A     KE     A T     AP
Sbjct: 635  TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAP 690

Query: 913  QDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAA 972
                  A  +  E             +P+ +  T   +P A  +P+KP   K+L      
Sbjct: 691  TTPKEPAPTTPKETAPT---------TPKGTAPTTLKEP-APTTPKKPAP-KELAPTTTK 739

Query: 973  IPPIVTKVHEPPREDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPA 1029
             P   T       +  APT P   AP  P  P    P+  AP  P  +     + PAP  
Sbjct: 740  EPTSTT------CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT 793

Query: 1030 DKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGH 1089
             K+       PA    A      P   TS  P P  P+E    +P  P P+         
Sbjct: 794  PKK-------PAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------- 838

Query: 1090 PLPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1123
                       P  P P T   PPP  S    P+
Sbjct: 839  -----------PKKPAPTTPETPPPTTSEVSTPT 861



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 123/544 (22%), Positives = 171/544 (31%), Gaps = 109/544 (20%)

Query: 783  PTPPPEDIPAPTEPTPASEATGAPTP-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGE 841
            PT PP    AP  P+ AS+   + T   P PP+      V+  EE  EE +    V E +
Sbjct: 110  PTSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHS----VSENQ 164

Query: 842  EQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD-----------------AEAAE 884
            E    ++   +  T +  +  K+       +   K KD                  EA  
Sbjct: 165  ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGS 224

Query: 885  ATAEGALKA---------EKKEGGSGRATTAK----SSGAPQDSDSS------------- 918
                G  K            K   S + TTAK        P +SD+S             
Sbjct: 225  GLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTV 284

Query: 919  ---ATCSADEVDEAEGGDKNR----------------------LLSPRPSLLTPTGDPRA 953
                T + ++    +G +K                        L  P P   T T  P A
Sbjct: 285  ETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-A 343

Query: 954  NASPQKPLDLKQLKQRAAAIP--PIVTKVHEPPREDAAP----TKPAPPAPPPPQNLQPE 1007
              +P++P      K+ A+  P  P  T +   P     P    TK AP  P  P     +
Sbjct: 344  LTTPKEPTPTTP-KEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 402

Query: 1008 SDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPR 1067
              AP  P       ++ PAP   K A      P     A   P  P   T   P P  P+
Sbjct: 403  EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP-----APTTPKKPAPTTPKEPAPTTPK 457

Query: 1068 EVIKASPHAPDPSAFSYAP--PGHPLPLGLHDTA--RPVLPRPPTISNPPPLISSAKHPS 1123
            E    +P  P P+    AP  P  P P      A   P  P P T   P P  +    P+
Sbjct: 458  EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 517

Query: 1124 VLERQIGAISQGMSVQLHVPYSEHAK-APV-----GPVTMGLPLPMDPKKLAPFSGVKQE 1177
              +      ++        P     K AP       P T   P P  PK+ AP +  K  
Sbjct: 518  TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 577

Query: 1178 QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSIT 1237
              +P+  A        PT  +                 T   P+   P ++A T    +T
Sbjct: 578  PTTPKEPAPTTPKEPAPTTTKKP------------APTTPKEPAPTTPKETAPTTPKKLT 625

Query: 1238 HGTP 1241
              TP
Sbjct: 626  PTTP 629



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%)

Query: 1745 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1804
            P  P    P    P T  +     P  P P +   + +      PT   KP  T+  E  
Sbjct: 440  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 499

Query: 1805 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1860
                +E      +E S  T    + TT + AP     T++ + ++  S         P +
Sbjct: 500  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 556

Query: 1861 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1920
                   +P  P      +  P+    T  +   T  +   PT  +  + ++P  PA T 
Sbjct: 557  TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 612

Query: 1921 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1966
            P  T       L    P  + P    K AP                  PE P   T  A 
Sbjct: 613  PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 672

Query: 1967 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2021
                  +P   +  EPA  P+   EP P  P  +   T   T P     P   +P  PAP
Sbjct: 673  APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 730

Query: 2022 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2071
               A    +E T +   KP               +  +P+G  P +P          P+ 
Sbjct: 731  KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 775

Query: 2072 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2126
            T  KG  P  L+E           PK+P P +L       P      +P P +   ++P 
Sbjct: 776  TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 829

Query: 2127 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2181
                   T P         T     SEV T   T+          P  ++  P  S P L
Sbjct: 830  TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 880

Query: 2182 DLRRPPSDLYLPPPDHGAPARGSP 2205
                 P  L   P + G P   +P
Sbjct: 881  SAEPTPKALENSPKEPGVPTTKTP 904



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 84/359 (23%), Positives = 128/359 (35%), Gaps = 52/359 (14%)

Query: 732  PRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIP 791
            P+G  + P T+   + T    +P   A K+      K P +  +D P    PT P E  P
Sbjct: 778  PKG--TAPTTLKEPAPT----TPKKPAPKELAPTTTKGPTSTTSDKP---APTTPKETAP 828

Query: 792  -APTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEE----GEEQKPP 846
              P EP P +    APT P  PP P+      P   KE  T    P E       E  P 
Sbjct: 829  TTPKEPAPTTPKKPAPTTPETPP-PTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK 887

Query: 847  AAE----ELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGR 902
            A E    E  V T K     K E T  A++   + +D      T   A K  K+      
Sbjct: 888  ALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----T 941

Query: 903  ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD 962
            ATT + +     ++S  T +  +V      D         +L T T  P+   +      
Sbjct: 942  ATTTEKT-----TESKITATTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT------ 988

Query: 963  LKQLKQRAAAIPPIVTKVHE--PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRG 1020
                 ++      I+ K  E   P++ A  +K   P P  P     +  + ++P + PR 
Sbjct: 989  -----KKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRV 1043

Query: 1021 KSRSPAP-PADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1078
            +     P P    +  P   P        L       T+  P   P  ++++ +P + D
Sbjct: 1044 RKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1096



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%)

Query: 1748 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1807
            P L  P   TP T  +  +  P  P P + +  S+P +P  P     PTTT S+      
Sbjct: 342  PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 392

Query: 1808 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1867
             +E      +E +    TT  E AP     T++ + ++  S         P +       
Sbjct: 393  PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 446

Query: 1868 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1925
            +P  P      +  P+    T  +   T  EP+ PT  +  + ++P +PA T P  PA  
Sbjct: 447  TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 501

Query: 1926 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1985
             P             EP     + P    P+ P   T      K    +  EPA + +K 
Sbjct: 502  TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 544

Query: 1986 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2038
            +   P  P  +     A T  K  AP   +P  PAP       P +  +P    T+    
Sbjct: 545  APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 602

Query: 2039 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2096
            +  +    +     +  +P+ + P +P      T +K  P   EEL  +  E      P+
Sbjct: 603  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 662

Query: 2097 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2131
            +P P      A + P   P P +    +P     P
Sbjct: 663  EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 696



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%)

Query: 1565 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1624
            +P TT+EP P   +    ++        T +     K P  T P+  P P +P E     
Sbjct: 397  APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 451

Query: 1625 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1678
                       P    PT+     P     A   P+  AP       PT P    P   +
Sbjct: 452  -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 504

Query: 1679 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1737
                T   E   T   +   T+ +         A         +P+E S        P  
Sbjct: 505  EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 562

Query: 1738 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1796
                   P  P    P    P T  +     P  P P +++   +P +P  P   T K T
Sbjct: 563  -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 616

Query: 1797 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1852
              ++ ++      E+      EK     TT  E AP       P T +    +       
Sbjct: 617  APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 674

Query: 1853 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1912
             +   PA        +P  P      +  P+    T      T  + + PT L+  + ++
Sbjct: 675  NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 724

Query: 1913 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1965
            P +PA     P  T  P   T D   PT  +   P    + AP   +   P    G A  
Sbjct: 725  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 784

Query: 1966 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2018
                      K PA   L P ++    S       P +   T   TP +   P   +P  
Sbjct: 785  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 841

Query: 2019 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2078
            PAP    + P      S P + +E              P  +      S+P L+ +   P
Sbjct: 842  PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 886

Query: 2079 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2122
            K LE            PK+PG       AA  P              LR  PE   + P 
Sbjct: 887  KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 936

Query: 2123 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2182
             +    T        ++      ++   TQD T      L     AP  +    +    +
Sbjct: 937  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 996

Query: 2183 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2242
            +   P +    P D    ++ +        +P+P K            P   P+  T   
Sbjct: 997  IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 1034

Query: 2243 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2300
              +    P + +      P +M S  P    TS+      + T   +    SK  E+N K
Sbjct: 1035 -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1093



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 80/352 (22%), Positives = 125/352 (35%), Gaps = 56/352 (15%)

Query: 735  ECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAP 793
            E +   T   +S T   P+P T   K+T    PK PA      P P  P TPPP      
Sbjct: 801  ELAPTTTKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 858

Query: 794  TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAV 853
            T  T     T   +P  + P  SA P     E   +E             K PAA +  +
Sbjct: 859  TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEM 911

Query: 854  DTGKAEEPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG-------- 901
             T   ++  + +     E   A  K     A   E T E  + A   +  S         
Sbjct: 912  TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF 971

Query: 902  RATTAKSSG-APQDSDSSATCSADEV-----DEAEGGDK---NRLLSPRPSLLTPTGDPR 952
            + TT K++  AP+ + +  T +  E+     + A+  D+   ++  +P+P    PT  P+
Sbjct: 972  KITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQ--KPTKAPK 1029

Query: 953  ANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQ 1012
               S +KP  + ++++          K    PR+    T   P   P  +  +       
Sbjct: 1030 KPTSTKKPKTMPRVRK---------PKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTT 1077

Query: 1013 QPGSSPRGKSRSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1053
            +P  +P  K     P ++     E E P       VF P    +   LP  P
Sbjct: 1078 RPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1129


>gi|209977080 REST corepressor 3 isoform a [Homo sapiens]
          Length = 553

 Score =  112 bits (280), Expect = 5e-24
 Identities = 107/413 (25%), Positives = 166/413 (40%), Gaps = 55/413 (13%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K+F  I   L  KT+A  V YYY  KK  +  SL+ R  R   
Sbjct: 147 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 203

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545
           K   +  Q       ++  PM  +  +   +KE +KE   E+    V+  K  L      
Sbjct: 204 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 260

Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592
                    + K     G    +++ VA S     AN+  R+       + R + N    
Sbjct: 261 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 320

Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647
             A+  +    +   +  ES+     RWT EE   A +G+ ++G+++ AIA ++G+KTV 
Sbjct: 321 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 380

Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707
           Q KNF+ NY++R NL+E+LQ+     E E+  +     A     E  +   V        
Sbjct: 381 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 429

Query: 708 SGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIP--SPHTEAAKDTGQN 765
           SG S +EEE  +  +A    G   P    +   T   ++  +  P   P   AA    + 
Sbjct: 430 SGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQ 489

Query: 766 GP---------KPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP 809
            P         +P  TL     PP P   P   +P    P P     G   PP
Sbjct: 490 PPPLQQQARFIQPRPTL---NQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPP 539



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 6/118 (5%)

Query: 1002 QNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLP 1061
            Q  Q  +      G   +  S  P+  +  E E+     A   +A +  G  P   S  P
Sbjct: 406  QGTQASNGDASTLGEETKSASNVPSGKSTDEEEE-----AQTPQAPRTLGPSPPAPSSTP 460

Query: 1062 FPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSA 1119
             P  P   +   P    P+    AP  H  P  L   AR + PRP     PPPLI  A
Sbjct: 461  TPTAPIATLNQPPPLLRPT-LPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPA 517



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 37/138 (26%), Positives = 56/138 (40%), Gaps = 13/138 (9%)

Query: 884  EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 943
            E  AE   +A   +  +    T  +S  P         S DE +EA+     R L P P 
Sbjct: 401  EWEAEQGTQASNGDASTLGEETKSASNVPSGK------STDEEEEAQTPQAPRTLGPSPP 454

Query: 944  LLTPTGDPRAN-ASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPA-PPPP 1001
              + T  P A  A+  +P  L +    AA   P + +   P ++ A   +P P    PPP
Sbjct: 455  APSSTPTPTAPIATLNQPPPLLRPTLPAA---PALHRQPPPLQQQARFIQPRPTLNQPPP 511

Query: 1002 QNLQPESDAPQQPGSSPR 1019
              ++P +  P  P  +PR
Sbjct: 512  PLIRPANSMP--PRLNPR 527


>gi|8922733 REST corepressor 3 isoform d [Homo sapiens]
          Length = 495

 Score =  112 bits (280), Expect = 5e-24
 Identities = 107/413 (25%), Positives = 166/413 (40%), Gaps = 55/413 (13%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K+F  I   L  KT+A  V YYY  KK  +  SL+ R  R   
Sbjct: 89  WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 145

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545
           K   +  Q       ++  PM  +  +   +KE +KE   E+    V+  K  L      
Sbjct: 146 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 202

Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592
                    + K     G    +++ VA S     AN+  R+       + R + N    
Sbjct: 203 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 262

Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647
             A+  +    +   +  ES+     RWT EE   A +G+ ++G+++ AIA ++G+KTV 
Sbjct: 263 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 322

Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707
           Q KNF+ NY++R NL+E+LQ+     E E+  +     A     E  +   V        
Sbjct: 323 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 371

Query: 708 SGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIP--SPHTEAAKDTGQN 765
           SG S +EEE  +  +A    G   P    +   T   ++  +  P   P   AA    + 
Sbjct: 372 SGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQ 431

Query: 766 GP---------KPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP 809
            P         +P  TL     PP P   P   +P    P P     G   PP
Sbjct: 432 PPPLQQQARFIQPRPTL---NQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPP 481



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 6/118 (5%)

Query: 1002 QNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLP 1061
            Q  Q  +      G   +  S  P+  +  E E+     A   +A +  G  P   S  P
Sbjct: 348  QGTQASNGDASTLGEETKSASNVPSGKSTDEEEE-----AQTPQAPRTLGPSPPAPSSTP 402

Query: 1062 FPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSA 1119
             P  P   +   P    P+    AP  H  P  L   AR + PRP     PPPLI  A
Sbjct: 403  TPTAPIATLNQPPPLLRPT-LPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPA 459



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 37/138 (26%), Positives = 56/138 (40%), Gaps = 13/138 (9%)

Query: 884  EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 943
            E  AE   +A   +  +    T  +S  P         S DE +EA+     R L P P 
Sbjct: 343  EWEAEQGTQASNGDASTLGEETKSASNVPSGK------STDEEEEAQTPQAPRTLGPSPP 396

Query: 944  LLTPTGDPRAN-ASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPA-PPPP 1001
              + T  P A  A+  +P  L +    AA   P + +   P ++ A   +P P    PPP
Sbjct: 397  APSSTPTPTAPIATLNQPPPLLRPTLPAA---PALHRQPPPLQQQARFIQPRPTLNQPPP 453

Query: 1002 QNLQPESDAPQQPGSSPR 1019
              ++P +  P  P  +PR
Sbjct: 454  PLIRPANSMP--PRLNPR 469


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  106 bits (265), Expect = 3e-22
 Identities = 165/700 (23%), Positives = 234/700 (33%), Gaps = 101/700 (14%)

Query: 518  EEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGR 577
            E KD K K +  +K   KP V ++            SG DN + +        T +++  
Sbjct: 65   EVKDNK-KNRTKKKPTPKPPVVDEAG----------SGLDNGDFKVTTPDTSTTQHNKVS 113

Query: 578  RKGRITRSMANEANSEEAITPQQ-SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSA 636
               +IT   A   N   ++ P   +++  S+ +N+ +    +E  T  K     G+  + 
Sbjct: 114  TSPKITT--AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 171

Query: 637  IARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME---KERNARRKKKKAPAAASEE 693
             A+   S   +  K+     K       +L +   K E   K       K+  P    E 
Sbjct: 172  SAKETQSIEKTSAKDLAPTSK-------VLAKPTPKAETTTKGPALTTPKEPTPTTPKEP 224

Query: 694  AAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPS 753
            A+  P    +E   + +        E A     S    P+ E +   T   +  T   P+
Sbjct: 225  ASTTP----KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEPAPTTPKEPA 279

Query: 754  PHT--EAAKDTGQNGP------------KPPATLGADGPPPGP----PTPPPEDIPAPTE 795
            P T  E A  T ++ P            KP  T   +  P  P    PT P E  P   E
Sbjct: 280  PTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKE 339

Query: 796  PTPASEATGAPTPP--PAPPSPSAPPPVVPKE------EKEEETAAAPPVEEGEEQKPPA 847
            P P +    APT P  PAP +P  P P  PKE      ++   T    P     +  P  
Sbjct: 340  PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 399

Query: 848  AEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 907
             +E A  T K+      E +    + PA     E A  T +       KE     A T  
Sbjct: 400  TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE----PAPTTP 455

Query: 908  SSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPR-ANASPQKPLDLKQL 966
               AP  +   A  +  E                P  LTPT   + A  +P+KP      
Sbjct: 456  KEPAPTTTKKPAPTTPKEPAPT---TPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP- 511

Query: 967  KQRAAAIP--PIVTKVHEP------------PREDA--APTKPAPPAPPPPQNLQPESDA 1010
            ++ A   P  P  T   EP            P+E A   P +PAP  P  P    P+  A
Sbjct: 512  EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA 571

Query: 1011 PQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVI 1070
            P  P  +     + PAP   K+       PA    A     +P   T   P P  P+   
Sbjct: 572  PTTPKGTAPTTLKEPAPTTPKK-------PAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 624

Query: 1071 KASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIG 1130
              +P  P P+      P  P P     TA      P T+  P P       P  L     
Sbjct: 625  PTTPKEPAPTT-----PKEPAPTTPKGTA------PTTLKEPAPTTPKKPAPKELAPTTT 673

Query: 1131 AISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAP 1170
                  +     P +    AP  P     P P  PKK AP
Sbjct: 674  KGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKKPAP 710



 Score =  105 bits (263), Expect = 4e-22
 Identities = 139/512 (27%), Positives = 187/512 (36%), Gaps = 69/512 (13%)

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 798
            P T+ ++  T   P+P T  +  T    PK PA      P P   T P E  P  T+   
Sbjct: 234  PTTIKSAPTTPKEPAPTTTKSAPTT---PKEPAPTTTKEPAP---TTPKEPAPTTTKEPA 287

Query: 799  ASEATGAPTPP--PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 856
             +    APT P  PAP +P  P P  PKE     T    P     ++  P  +E A  T 
Sbjct: 288  PTTTKSAPTTPKEPAPTTPKKPAPTTPKE--PAPTTPKEPTPTTPKEPAPTTKEPAPTTP 345

Query: 857  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 916
            K   P        A + PA     E A  T +       KE     + T     AP  + 
Sbjct: 346  KEPAPT-------APKKPAPTTPKEPAPTTPKEPAPTTTKE----PSPTTPKEPAPTTTK 394

Query: 917  SSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPI 976
            S+ T +    + A    K+   +P+    T T +P A  +P++P      K       P 
Sbjct: 395  SAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEP-APTTPKEPAPTTPKK-------PA 443

Query: 977  VTKVHEP----PREDAAPT--KPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPP-- 1028
             T   EP    P+E A  T  KPAP  P  P    P+  AP  P      K  +P  P  
Sbjct: 444  PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTP------KKLTPTTPEK 497

Query: 1029 -ADKEAEKPVFFPAFAAE-AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSA-FSYA 1085
             A    EKP   P    E A   P +P   T   P P  P+     +P  P P+     A
Sbjct: 498  LAPTTPEKPA--PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 555

Query: 1086 P--PGHPLPLGLHDTARPVLPR---PPTISNPPPLISSAKHPSVLERQIGAISQGMSVQL 1140
            P  P  P P    +TA P  P+   P T+  P P  ++ K P+  E       +  S   
Sbjct: 556  PTTPKEPAPTTPKETA-PTTPKGTAPTTLKEPAP--TTPKKPAPKELAPTTTKEPTSTTC 612

Query: 1141 HVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1200
              P     K    P T   P P  PK+ AP         +P+G A        PT  +  
Sbjct: 613  DKPAPTTPKG-TAPTTPKEPAPTTPKEPAP--------TTPKGTAPTTLKEPAPTTPKKP 663

Query: 1201 VLRGTALGSVPG-GSITKGIPSTRVPSDSAIT 1231
              +  A  +  G  S T   P+   P ++A T
Sbjct: 664  APKELAPTTTKGPTSTTSDKPAPTTPKETAPT 695



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 103/394 (26%), Positives = 130/394 (32%), Gaps = 65/394 (16%)

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-- 796
            P T  ++  T   P+P T  +  T    P P  T       P  P P     PAPT P  
Sbjct: 390  PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 449

Query: 797  ---TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAV 853
               T   E     T  PAP +P  P P  PK     ETA   P    ++  P   E+LA 
Sbjct: 450  PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAP 500

Query: 854  DTGKAEEP-VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAP 912
             T +   P    E      E P      E A  T + A     KE     A T     AP
Sbjct: 501  TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAP 556

Query: 913  QDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAA 972
                  A  +  E             +P+ +  T   +P A  +P+KP   K+L      
Sbjct: 557  TTPKEPAPTTPKETAPT---------TPKGTAPTTLKEP-APTTPKKPAP-KELAPTTTK 605

Query: 973  IPPIVTKVHEPPREDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPA 1029
             P   T       +  APT P   AP  P  P    P+  AP  P  +     + PAP  
Sbjct: 606  EPTSTT------CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT 659

Query: 1030 DKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGH 1089
             K+       PA    A      P   TS  P P  P+E    +P  P P+         
Sbjct: 660  PKK-------PAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------- 704

Query: 1090 PLPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1123
                       P  P P T   PPP  S    P+
Sbjct: 705  -----------PKKPAPTTPETPPPTTSEVSTPT 727



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%)

Query: 1745 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1804
            P  P    P    P T  +     P  P P +   + +      PT   KP  T+  E  
Sbjct: 306  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 365

Query: 1805 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1860
                +E      +E S  T    + TT + AP     T++ + ++  S         P +
Sbjct: 366  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 422

Query: 1861 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1920
                   +P  P      +  P+    T  +   T  +   PT  +  + ++P  PA T 
Sbjct: 423  TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 478

Query: 1921 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1966
            P  T       L    P  + P    K AP                  PE P   T  A 
Sbjct: 479  PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 538

Query: 1967 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2021
                  +P   +  EPA  P+   EP P  P  +   T   T P     P   +P  PAP
Sbjct: 539  APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 596

Query: 2022 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2071
               A    +E T +   KP               +  +P+G  P +P          P+ 
Sbjct: 597  KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 641

Query: 2072 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2126
            T  KG  P  L+E           PK+P P +L       P      +P P +   ++P 
Sbjct: 642  TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 695

Query: 2127 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2181
                   T P         T     SEV T   T+          P  ++  P  S P L
Sbjct: 696  TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 746

Query: 2182 DLRRPPSDLYLPPPDHGAPARGSP 2205
                 P  L   P + G P   +P
Sbjct: 747  SAEPTPKALENSPKEPGVPTTKTP 770



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 84/359 (23%), Positives = 128/359 (35%), Gaps = 52/359 (14%)

Query: 732  PRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIP 791
            P+G  + P T+   + T    +P   A K+      K P +  +D P    PT P E  P
Sbjct: 644  PKG--TAPTTLKEPAPT----TPKKPAPKELAPTTTKGPTSTTSDKP---APTTPKETAP 694

Query: 792  -APTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEE----GEEQKPP 846
              P EP P +    APT P  PP P+      P   KE  T    P E       E  P 
Sbjct: 695  TTPKEPAPTTPKKPAPTTPETPP-PTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK 753

Query: 847  AAE----ELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGR 902
            A E    E  V T K     K E T  A++   + +D      T   A K  K+      
Sbjct: 754  ALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----T 807

Query: 903  ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD 962
            ATT + +     ++S  T +  +V      D         +L T T  P+   +      
Sbjct: 808  ATTTEKT-----TESKITATTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT------ 854

Query: 963  LKQLKQRAAAIPPIVTKVHE--PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRG 1020
                 ++      I+ K  E   P++ A  +K   P P  P     +  + ++P + PR 
Sbjct: 855  -----KKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRV 909

Query: 1021 KSRSPAP-PADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1078
            +     P P    +  P   P        L       T+  P   P  ++++ +P + D
Sbjct: 910  RKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 962



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%)

Query: 1748 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1807
            P L  P   TP T  +  +  P  P P + +  S+P +P  P     PTTT S+      
Sbjct: 208  PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 258

Query: 1808 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1867
             +E      +E +    TT  E AP     T++ + ++  S         P +       
Sbjct: 259  PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 312

Query: 1868 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1925
            +P  P      +  P+    T  +   T  EP+ PT  +  + ++P +PA T P  PA  
Sbjct: 313  TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 367

Query: 1926 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1985
             P             EP     + P    P+ P   T      K    +  EPA + +K 
Sbjct: 368  TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 410

Query: 1986 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2038
            +   P  P  +     A T  K  AP   +P  PAP       P +  +P    T+    
Sbjct: 411  APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 468

Query: 2039 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2096
            +  +    +     +  +P+ + P +P      T +K  P   EEL  +  E      P+
Sbjct: 469  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 528

Query: 2097 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2131
            +P P      A + P   P P +    +P     P
Sbjct: 529  EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 562



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%)

Query: 1565 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1624
            +P TT+EP P   +    ++        T +     K P  T P+  P P +P E     
Sbjct: 263  APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 317

Query: 1625 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1678
                       P    PT+     P     A   P+  AP       PT P    P   +
Sbjct: 318  -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 370

Query: 1679 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1737
                T   E   T   +   T+ +         A         +P+E S        P  
Sbjct: 371  EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 428

Query: 1738 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1796
                   P  P    P    P T  +     P  P P +++   +P +P  P   T K T
Sbjct: 429  -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 482

Query: 1797 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1852
              ++ ++      E+      EK     TT  E AP       P T +    +       
Sbjct: 483  APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 540

Query: 1853 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1912
             +   PA        +P  P      +  P+    T      T  + + PT L+  + ++
Sbjct: 541  NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 590

Query: 1913 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1965
            P +PA     P  T  P   T D   PT  +   P    + AP   +   P    G A  
Sbjct: 591  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 650

Query: 1966 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2018
                      K PA   L P ++    S       P +   T   TP +   P   +P  
Sbjct: 651  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 707

Query: 2019 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2078
            PAP    + P      S P + +E              P  +      S+P L+ +   P
Sbjct: 708  PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 752

Query: 2079 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2122
            K LE            PK+PG       AA  P              LR  PE   + P 
Sbjct: 753  KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 802

Query: 2123 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2182
             +    T        ++      ++   TQD T      L     AP  +    +    +
Sbjct: 803  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 862

Query: 2183 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2242
            +   P +    P D    ++ +        +P+P K            P   P+  T   
Sbjct: 863  IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 900

Query: 2243 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2300
              +    P + +      P +M S  P    TS+      + T   +    SK  E+N K
Sbjct: 901  -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 959



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 80/352 (22%), Positives = 125/352 (35%), Gaps = 56/352 (15%)

Query: 735  ECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAP 793
            E +   T   +S T   P+P T   K+T    PK PA      P P  P TPPP      
Sbjct: 667  ELAPTTTKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 724

Query: 794  TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAV 853
            T  T     T   +P  + P  SA P     E   +E             K PAA +  +
Sbjct: 725  TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEM 777

Query: 854  DTGKAEEPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG-------- 901
             T   ++  + +     E   A  K     A   E T E  + A   +  S         
Sbjct: 778  TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF 837

Query: 902  RATTAKSSG-APQDSDSSATCSADEV-----DEAEGGDK---NRLLSPRPSLLTPTGDPR 952
            + TT K++  AP+ + +  T +  E+     + A+  D+   ++  +P+P    PT  P+
Sbjct: 838  KITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQ--KPTKAPK 895

Query: 953  ANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQ 1012
               S +KP  + ++++          K    PR+    T   P   P  +  +       
Sbjct: 896  KPTSTKKPKTMPRVRK---------PKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTT 943

Query: 1013 QPGSSPRGKSRSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1053
            +P  +P  K     P ++     E E P       VF P    +   LP  P
Sbjct: 944  RPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 995


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  106 bits (265), Expect = 3e-22
 Identities = 165/700 (23%), Positives = 234/700 (33%), Gaps = 101/700 (14%)

Query: 518  EEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGR 577
            E KD K K +  +K   KP V ++            SG DN + +        T +++  
Sbjct: 106  EVKDNK-KNRTKKKPTPKPPVVDEAG----------SGLDNGDFKVTTPDTSTTQHNKVS 154

Query: 578  RKGRITRSMANEANSEEAITPQQ-SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSA 636
               +IT   A   N   ++ P   +++  S+ +N+ +    +E  T  K     G+  + 
Sbjct: 155  TSPKITT--AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 212

Query: 637  IARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME---KERNARRKKKKAPAAASEE 693
             A+   S   +  K+     K       +L +   K E   K       K+  P    E 
Sbjct: 213  SAKETQSIEKTSAKDLAPTSK-------VLAKPTPKAETTTKGPALTTPKEPTPTTPKEP 265

Query: 694  AAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPS 753
            A+  P    +E   + +        E A     S    P+ E +   T   +  T   P+
Sbjct: 266  ASTTP----KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEPAPTTPKEPA 320

Query: 754  PHT--EAAKDTGQNGP------------KPPATLGADGPPPGP----PTPPPEDIPAPTE 795
            P T  E A  T ++ P            KP  T   +  P  P    PT P E  P   E
Sbjct: 321  PTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKE 380

Query: 796  PTPASEATGAPTPP--PAPPSPSAPPPVVPKE------EKEEETAAAPPVEEGEEQKPPA 847
            P P +    APT P  PAP +P  P P  PKE      ++   T    P     +  P  
Sbjct: 381  PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 440

Query: 848  AEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 907
             +E A  T K+      E +    + PA     E A  T +       KE     A T  
Sbjct: 441  TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE----PAPTTP 496

Query: 908  SSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPR-ANASPQKPLDLKQL 966
               AP  +   A  +  E                P  LTPT   + A  +P+KP      
Sbjct: 497  KEPAPTTTKKPAPTTPKEPAPT---TPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP- 552

Query: 967  KQRAAAIP--PIVTKVHEP------------PREDA--APTKPAPPAPPPPQNLQPESDA 1010
            ++ A   P  P  T   EP            P+E A   P +PAP  P  P    P+  A
Sbjct: 553  EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA 612

Query: 1011 PQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVI 1070
            P  P  +     + PAP   K+       PA    A     +P   T   P P  P+   
Sbjct: 613  PTTPKGTAPTTLKEPAPTTPKK-------PAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 665

Query: 1071 KASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIG 1130
              +P  P P+      P  P P     TA      P T+  P P       P  L     
Sbjct: 666  PTTPKEPAPTT-----PKEPAPTTPKGTA------PTTLKEPAPTTPKKPAPKELAPTTT 714

Query: 1131 AISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAP 1170
                  +     P +    AP  P     P P  PKK AP
Sbjct: 715  KGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKKPAP 751



 Score =  105 bits (263), Expect = 4e-22
 Identities = 139/512 (27%), Positives = 187/512 (36%), Gaps = 69/512 (13%)

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 798
            P T+ ++  T   P+P T  +  T    PK PA      P P   T P E  P  T+   
Sbjct: 275  PTTIKSAPTTPKEPAPTTTKSAPTT---PKEPAPTTTKEPAP---TTPKEPAPTTTKEPA 328

Query: 799  ASEATGAPTPP--PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 856
             +    APT P  PAP +P  P P  PKE     T    P     ++  P  +E A  T 
Sbjct: 329  PTTTKSAPTTPKEPAPTTPKKPAPTTPKE--PAPTTPKEPTPTTPKEPAPTTKEPAPTTP 386

Query: 857  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 916
            K   P        A + PA     E A  T +       KE     + T     AP  + 
Sbjct: 387  KEPAPT-------APKKPAPTTPKEPAPTTPKEPAPTTTKE----PSPTTPKEPAPTTTK 435

Query: 917  SSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPI 976
            S+ T +    + A    K+   +P+    T T +P A  +P++P      K       P 
Sbjct: 436  SAPTTTK---EPAPTTTKSAPTTPKEPSPTTTKEP-APTTPKEPAPTTPKK-------PA 484

Query: 977  VTKVHEP----PREDAAPT--KPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPP-- 1028
             T   EP    P+E A  T  KPAP  P  P    P+  AP  P      K  +P  P  
Sbjct: 485  PTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTP------KKLTPTTPEK 538

Query: 1029 -ADKEAEKPVFFPAFAAE-AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSA-FSYA 1085
             A    EKP   P    E A   P +P   T   P P  P+     +P  P P+     A
Sbjct: 539  LAPTTPEKPA--PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 596

Query: 1086 P--PGHPLPLGLHDTARPVLPR---PPTISNPPPLISSAKHPSVLERQIGAISQGMSVQL 1140
            P  P  P P    +TA P  P+   P T+  P P  ++ K P+  E       +  S   
Sbjct: 597  PTTPKEPAPTTPKETA-PTTPKGTAPTTLKEPAP--TTPKKPAPKELAPTTTKEPTSTTC 653

Query: 1141 HVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1200
              P     K    P T   P P  PK+ AP         +P+G A        PT  +  
Sbjct: 654  DKPAPTTPKG-TAPTTPKEPAPTTPKEPAP--------TTPKGTAPTTLKEPAPTTPKKP 704

Query: 1201 VLRGTALGSVPG-GSITKGIPSTRVPSDSAIT 1231
              +  A  +  G  S T   P+   P ++A T
Sbjct: 705  APKELAPTTTKGPTSTTSDKPAPTTPKETAPT 736



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 103/394 (26%), Positives = 130/394 (32%), Gaps = 65/394 (16%)

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-- 796
            P T  ++  T   P+P T  +  T    P P  T       P  P P     PAPT P  
Sbjct: 431  PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 490

Query: 797  ---TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAV 853
               T   E     T  PAP +P  P P  PK     ETA   P    ++  P   E+LA 
Sbjct: 491  PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAP 541

Query: 854  DTGKAEEP-VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAP 912
             T +   P    E      E P      E A  T + A     KE     A T     AP
Sbjct: 542  TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAP 597

Query: 913  QDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAA 972
                  A  +  E             +P+ +  T   +P A  +P+KP   K+L      
Sbjct: 598  TTPKEPAPTTPKETAPT---------TPKGTAPTTLKEP-APTTPKKPAP-KELAPTTTK 646

Query: 973  IPPIVTKVHEPPREDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPA 1029
             P   T       +  APT P   AP  P  P    P+  AP  P  +     + PAP  
Sbjct: 647  EPTSTT------CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT 700

Query: 1030 DKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGH 1089
             K+       PA    A      P   TS  P P  P+E    +P  P P+         
Sbjct: 701  PKK-------PAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------- 745

Query: 1090 PLPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1123
                       P  P P T   PPP  S    P+
Sbjct: 746  -----------PKKPAPTTPETPPPTTSEVSTPT 768



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%)

Query: 1745 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1804
            P  P    P    P T  +     P  P P +   + +      PT   KP  T+  E  
Sbjct: 347  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 406

Query: 1805 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1860
                +E      +E S  T    + TT + AP     T++ + ++  S         P +
Sbjct: 407  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 463

Query: 1861 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1920
                   +P  P      +  P+    T  +   T  +   PT  +  + ++P  PA T 
Sbjct: 464  TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 519

Query: 1921 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1966
            P  T       L    P  + P    K AP                  PE P   T  A 
Sbjct: 520  PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 579

Query: 1967 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2021
                  +P   +  EPA  P+   EP P  P  +   T   T P     P   +P  PAP
Sbjct: 580  APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 637

Query: 2022 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2071
               A    +E T +   KP               +  +P+G  P +P          P+ 
Sbjct: 638  KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 682

Query: 2072 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2126
            T  KG  P  L+E           PK+P P +L       P      +P P +   ++P 
Sbjct: 683  TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 736

Query: 2127 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2181
                   T P         T     SEV T   T+          P  ++  P  S P L
Sbjct: 737  TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 787

Query: 2182 DLRRPPSDLYLPPPDHGAPARGSP 2205
                 P  L   P + G P   +P
Sbjct: 788  SAEPTPKALENSPKEPGVPTTKTP 811



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 84/359 (23%), Positives = 128/359 (35%), Gaps = 52/359 (14%)

Query: 732  PRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIP 791
            P+G  + P T+   + T    +P   A K+      K P +  +D P    PT P E  P
Sbjct: 685  PKG--TAPTTLKEPAPT----TPKKPAPKELAPTTTKGPTSTTSDKP---APTTPKETAP 735

Query: 792  -APTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEE----GEEQKPP 846
              P EP P +    APT P  PP P+      P   KE  T    P E       E  P 
Sbjct: 736  TTPKEPAPTTPKKPAPTTPETPP-PTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK 794

Query: 847  AAE----ELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGR 902
            A E    E  V T K     K E T  A++   + +D      T   A K  K+      
Sbjct: 795  ALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----T 848

Query: 903  ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD 962
            ATT + +     ++S  T +  +V      D         +L T T  P+   +      
Sbjct: 849  ATTTEKT-----TESKITATTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT------ 895

Query: 963  LKQLKQRAAAIPPIVTKVHE--PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRG 1020
                 ++      I+ K  E   P++ A  +K   P P  P     +  + ++P + PR 
Sbjct: 896  -----KKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRV 950

Query: 1021 KSRSPAP-PADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1078
            +     P P    +  P   P        L       T+  P   P  ++++ +P + D
Sbjct: 951  RKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1003



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%)

Query: 1748 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1807
            P L  P   TP T  +  +  P  P P + +  S+P +P  P     PTTT S+      
Sbjct: 249  PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 299

Query: 1808 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1867
             +E      +E +    TT  E AP     T++ + ++  S         P +       
Sbjct: 300  PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 353

Query: 1868 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1925
            +P  P      +  P+    T  +   T  EP+ PT  +  + ++P +PA T P  PA  
Sbjct: 354  TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 408

Query: 1926 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1985
             P             EP     + P    P+ P   T      K    +  EPA + +K 
Sbjct: 409  TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 451

Query: 1986 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2038
            +   P  P  +     A T  K  AP   +P  PAP       P +  +P    T+    
Sbjct: 452  APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 509

Query: 2039 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2096
            +  +    +     +  +P+ + P +P      T +K  P   EEL  +  E      P+
Sbjct: 510  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 569

Query: 2097 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2131
            +P P      A + P   P P +    +P     P
Sbjct: 570  EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 603



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%)

Query: 1565 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1624
            +P TT+EP P   +    ++        T +     K P  T P+  P P +P E     
Sbjct: 304  APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 358

Query: 1625 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1678
                       P    PT+     P     A   P+  AP       PT P    P   +
Sbjct: 359  -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 411

Query: 1679 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1737
                T   E   T   +   T+ +         A         +P+E S        P  
Sbjct: 412  EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 469

Query: 1738 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1796
                   P  P    P    P T  +     P  P P +++   +P +P  P   T K T
Sbjct: 470  -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 523

Query: 1797 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1852
              ++ ++      E+      EK     TT  E AP       P T +    +       
Sbjct: 524  APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 581

Query: 1853 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1912
             +   PA        +P  P      +  P+    T      T  + + PT L+  + ++
Sbjct: 582  NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 631

Query: 1913 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1965
            P +PA     P  T  P   T D   PT  +   P    + AP   +   P    G A  
Sbjct: 632  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 691

Query: 1966 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2018
                      K PA   L P ++    S       P +   T   TP +   P   +P  
Sbjct: 692  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 748

Query: 2019 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2078
            PAP    + P      S P + +E              P  +      S+P L+ +   P
Sbjct: 749  PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 793

Query: 2079 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2122
            K LE            PK+PG       AA  P              LR  PE   + P 
Sbjct: 794  KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 843

Query: 2123 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2182
             +    T        ++      ++   TQD T      L     AP  +    +    +
Sbjct: 844  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 903

Query: 2183 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2242
            +   P +    P D    ++ +        +P+P K            P   P+  T   
Sbjct: 904  IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 941

Query: 2243 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2300
              +    P + +      P +M S  P    TS+      + T   +    SK  E+N K
Sbjct: 942  -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1000



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 80/352 (22%), Positives = 125/352 (35%), Gaps = 56/352 (15%)

Query: 735  ECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAP 793
            E +   T   +S T   P+P T   K+T    PK PA      P P  P TPPP      
Sbjct: 708  ELAPTTTKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 765

Query: 794  TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAV 853
            T  T     T   +P  + P  SA P     E   +E             K PAA +  +
Sbjct: 766  TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEM 818

Query: 854  DTGKAEEPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG-------- 901
             T   ++  + +     E   A  K     A   E T E  + A   +  S         
Sbjct: 819  TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF 878

Query: 902  RATTAKSSG-APQDSDSSATCSADEV-----DEAEGGDK---NRLLSPRPSLLTPTGDPR 952
            + TT K++  AP+ + +  T +  E+     + A+  D+   ++  +P+P    PT  P+
Sbjct: 879  KITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQ--KPTKAPK 936

Query: 953  ANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQ 1012
               S +KP  + ++++          K    PR+    T   P   P  +  +       
Sbjct: 937  KPTSTKKPKTMPRVRK---------PKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTT 984

Query: 1013 QPGSSPRGKSRSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1053
            +P  +P  K     P ++     E E P       VF P    +   LP  P
Sbjct: 985  RPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1036


>gi|7661892 REST corepressor 1 [Homo sapiens]
          Length = 482

 Score =  105 bits (262), Expect = 6e-22
 Identities = 74/285 (25%), Positives = 134/285 (47%), Gaps = 19/285 (6%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K F  I   L  K++A  V +YY  KK     S++ R  R++ 
Sbjct: 192 WTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQ- 250

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDK-----EDLL 546
             +++++ + + ++     P+     E    KE +KE    E  P+V+ +K     ++  
Sbjct: 251 -KREREESEDELEEANGNNPI---DIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRA 306

Query: 547 KEKTDD---TSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAE 603
           K K       S ED +   A A+               + R + N   +  A+  +    
Sbjct: 307 KRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGG 366

Query: 604 LASMELNE-----SSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKK 658
           +    L E     ++RWT EE   A + + ++GR++ AI+ ++G+K+V Q KNF+ NY++
Sbjct: 367 IEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRR 426

Query: 659 RQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDE 703
           R N+DE+LQ+ + +  KE       +K P  + + +   P  EDE
Sbjct: 427 RFNIDEVLQEWEAEHGKEETNGPSNQK-PVKSPDNSIKMPEEEDE 470


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  101 bits (251), Expect = 1e-20
 Identities = 285/1276 (22%), Positives = 414/1276 (32%), Gaps = 214/1276 (16%)

Query: 739  PATVNNSSDTESIPSPHTEAAKDTG-QNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT 797
            P T   +S   +  SP  E       +N P    TL         P  P      P  P+
Sbjct: 660  PTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTT------LPLVPTASENCPVAPS 713

Query: 798  PASEATG------APTPPPAPPSPSAPPPVVPKEEKE----EETAAAPPVEEGEEQKP-- 845
            P +          AP  P + PSPS PP   P   K+      T+A  PV    ++ P  
Sbjct: 714  PQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTE 773

Query: 846  -PAAEELAVDTG------KAEEPVKSECTEEAEEGPAK----GKDAEAAEATA-----EG 889
               A   A   G       +  P+    + + +  P K    G D      ++     E 
Sbjct: 774  DSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEA 833

Query: 890  ALKAEKKEG--GSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLT- 946
            +   E      GS  +     S  P     + T SA      +G       +P PS++  
Sbjct: 834  SFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNL 893

Query: 947  --PTGDPRANASPQKP-LDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPA--PPAPPPP 1001
              P   P   A  Q P L +     + A   P    +   P    APT PA  PP+P   
Sbjct: 894  PFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGG 953

Query: 1002 QNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAF---------AAEAQKLPGD 1052
                    AP  P ++P      PA P+ K A  P   PA          A  + K    
Sbjct: 954  PATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP---PAATPPSPKGGPATPSPKGAPT 1010

Query: 1053 PPCWTSGLPFPVP---PREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTI 1109
            PP  T   P   P   P     ++P A  P +   +P   PLP G   T    LP P   
Sbjct: 1011 PPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGG 1070

Query: 1110 SNPPPLISSAKHPSVL-ERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKL 1168
               P L  +   P+       G  +        +P +    +P G    GL  P  P K 
Sbjct: 1071 PATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKG----GLATP--PHKG 1124

Query: 1169 APFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSIT---KGIPSTRVP 1225
            AP +       SP+G    P   G PT   A+        S  GG  T   KG P+T  P
Sbjct: 1125 APTTPAATPP-SPKGGLATPPPKGAPTTPAATP------PSPKGGLATPPPKGAPTT--P 1175

Query: 1226 SDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVL 1285
            + +  + +G +   +P     KG  T       PS          PKG +     KG   
Sbjct: 1176 AATPPSPKGGLATPSP-----KGAPT-TPAATPPS----------PKGGLATPSPKGAPT 1219

Query: 1286 SYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPE 1345
            +     + T  S + G ++  P      P  T    +G               G A PP 
Sbjct: 1220 T----PAATPPSPKGGLATPSPKGAPTTPAATPPSPKG---------------GPATPPP 1260

Query: 1346 RHSP-HHLKEQHHIRGSIT----QGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPSRDL 1400
            + +P         ++G +     +G P   V                    PP P     
Sbjct: 1261 KGAPTPPAATPPSLKGGLATPPHKGAPNPAV------------------VTPPSPKGGPA 1302

Query: 1401 TEAYKTQALGPLKLKPAHEGLVATVKEAGR-SIHEIPREELRHTPELPLAPRPLKEGSIT 1459
            T   K     P    P+ +G   T    G  +   +     + TP LP A  P  +G  T
Sbjct: 1303 TSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLP-ATTPSSKGGPT 1361

Query: 1460 QGTPLKYDTGASTTGSKKHDVRSLIGSPGR-----------TFPPVHPLD-VMADARALE 1507
              +  +  T  + T S K        SP R           T P V PL    A A  + 
Sbjct: 1362 TPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVT 1421

Query: 1508 R--------------ACYEESLKSRPGTASSSGGSI---ARGAPVI-------------- 1536
            R              A    SLK  P T++  GG     ++G P +              
Sbjct: 1422 REGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAP 1481

Query: 1537 --VPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTRE----PTPRLQEGSLSSSKASQDR 1590
              V     P+++P T    GAP    LP   P + +E    P+ R    + +++  S+  
Sbjct: 1482 KQVATSSSPKKAPATPAPMGAP---TLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKT 1538

Query: 1591 KLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSI-----P 1645
              T  P+E    P  TVP     P  P        +      +  P A  P++      P
Sbjct: 1539 PATLAPKEALIPPAMTVPSPKKTPAIPTPK--EAPATPSSKEASSPPAVTPSTYKGAPSP 1596

Query: 1646 RGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1705
            + + +  A     P+     PT P + PP   +G P T A +   T  +  +T   +  +
Sbjct: 1597 KELLIPPAVTSPSPKEA---PTPPAVTPPSPEKG-PATPAPKGTPT--SPPVTPSSLKDS 1650

Query: 1706 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVP---HLPVLVPPTPGTPATAM 1762
              +  +    M  G +  ++S  L    GP  + ++   P     P++  PT   P T  
Sbjct: 1651 PTSPASVTCKM--GATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKK 1708

Query: 1763 DRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSIL 1822
                  P  P P +   S  PLS   P  L  P    SS+  + +D          K  L
Sbjct: 1709 SSATSPPICPDPSAKNGSKGPLSTVAPAPLL-PVQKDSSKTAKGKDASHS-----PKGPL 1762

Query: 1823 TSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRP 1882
                +    P+     E+       S     + S P S   A    P  P  Q  L   P
Sbjct: 1763 APPESKASTPLTAAAFEKVL-PKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSP 1821

Query: 1883 SVLHNTGMKGIITAVE 1898
             ++  +  K +  A E
Sbjct: 1822 GLVLESPSKPLAPADE 1837



 Score = 95.1 bits (235), Expect = 8e-19
 Identities = 131/520 (25%), Positives = 173/520 (33%), Gaps = 55/520 (10%)

Query: 732  PRGECSGPATVNNSSDTESIPSPHTEAAKDT-GQNGPKPPATLGADGPPPGPPTPPPEDI 790
            P+G  + PA    S       +P  + A        P P  +  A   P G PT P   +
Sbjct: 1005 PKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATL 1064

Query: 791  PAPTEPTPASEATGAPTPPPA-PPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAE 849
            P+P          GAPTPP A PPSP   P     +      AA PP  +G    PP   
Sbjct: 1065 PSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPP--- 1121

Query: 850  ELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSS 909
                       P     T  + +G       + A  T      + K     G   T    
Sbjct: 1122 -------HKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK-----GGLATPPPK 1169

Query: 910  GAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 969
            GAP       T  A      +GG      SP+ +  TP   P +          K     
Sbjct: 1170 GAP-------TTPAATPPSPKGGLATP--SPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220

Query: 970  AAAIPPIVTKVHEPPREDAAPTKPA--PPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP 1027
             AA PP        P    APT PA  PP+P       P   AP  P ++P       A 
Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLAT 1280

Query: 1028 PADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPP 1087
            P  K A  P      A      P   P  +     P PP     A+P +P  S  +  P 
Sbjct: 1281 PPHKGAPNP------AVVTPPSPKGGPATSPPKGAPTPP----AATPPSPKGSPGTPPPK 1330

Query: 1088 GHPLPLGL---HDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPY 1144
            G P P  +        P LP     S   P   S+K          +   G ++    P 
Sbjct: 1331 GAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPK 1390

Query: 1145 SEHA-KAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLR 1203
               A  +P G  T    +P+ PKK AP + V +E     G A P +    P A     + 
Sbjct: 1391 RGPAIPSPKGDPTSPAVIPLSPKK-APATPVTRE-----GAATPSKGDLTPPA-----VT 1439

Query: 1204 GTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPAD 1243
              +L   P  S  KG P+T  PS        ++T  +P +
Sbjct: 1440 PVSLKKAPATSAPKGGPAT--PSSKGDPTLPAVTPPSPKE 1477



 Score = 92.8 bits (229), Expect = 4e-18
 Identities = 238/996 (23%), Positives = 316/996 (31%), Gaps = 156/996 (15%)

Query: 724  LHASGNEVPRGECSGPATVNNSSDTE--SIPSPHTEAAKDTGQNGPKP------PATLGA 775
            L   G  +P  E   P+ VN     E  + P+P    A     + PK       P  + A
Sbjct: 873  LSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPA 932

Query: 776  DGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPA-PPSPSAPPPVVPKEEKEEETAAA 834
               P G PTPP    P+P           APTPP A PPSP   P     +      AA 
Sbjct: 933  SPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAAT 992

Query: 835  PPVEEG--------EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEAT 886
            PP  +G            PPA    +     A  P     +      P   K + AA   
Sbjct: 993  PPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPL 1052

Query: 887  AEGA--LKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSL 944
             +GA    A       G   T    GAP  +  +AT  + +   A    K    +P P  
Sbjct: 1053 PKGAPTTPAATLPSPKGGPATPSLKGAP--TPPAATPPSPKGGPATPSPKG---APMPPA 1107

Query: 945  LTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPA--PPAPPPPQ 1002
             TP       A+P      K      AA PP        P    APT PA  PP+P    
Sbjct: 1108 ATPPSPKGGLATPPH----KGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL 1163

Query: 1003 NLQPESDAPQQPGS---SPRGKSRSPAP---PADKEAEKPVFFPAFAAEAQK-----LPG 1051
               P   AP  P +   SP+G   +P+P   P    A  P      A  + K        
Sbjct: 1164 ATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAA 1223

Query: 1052 DPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPP--GHPLPL---------GLHDTAR 1100
             PP    GL  P P       +   P P      PP  G P P          GL     
Sbjct: 1224 TPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPH 1283

Query: 1101 PVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLP 1160
               P P  ++ P P    A  P       GA +   +       S     P G  T    
Sbjct: 1284 KGAPNPAVVTPPSPKGGPATSPPK-----GAPTPPAATPPSPKGSPGTPPPKGAPTPPAV 1338

Query: 1161 LPMDPKKL----APFSGVKQEQLSPRGQAGP------PESLGVPTAQEASVLRGTALGSV 1210
             P  PK      A     K    +P  + GP      P   G P     S  RG A+ S 
Sbjct: 1339 TPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSP 1398

Query: 1211 PGGSITKGI--PSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGRED 1268
             G   +  +   S +    + +T  G+ T         KG +T      +P  L +    
Sbjct: 1399 KGDPTSPAVIPLSPKKAPATPVTREGAATPS-------KGDLTP--PAVTPVSLKKAPAT 1449

Query: 1269 SLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRA 1328
            S PKG       KG         +VT  S          P E  APK+       +   A
Sbjct: 1450 SAPKGGPATPSSKGDPTL----PAVTPPS----------PKEPPAPKQVATSSSPKKAPA 1495

Query: 1329 ISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRRE--AKLLK 1386
              +      +   IP    SP  +          T    R  +      L ++  A L  
Sbjct: 1496 TPAPMGAPTLPAVIP---SSPKEV--------PATPSSRRDPIAPTATLLSKKTPATLAP 1544

Query: 1387 REGTPPP--PPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTP 1444
            +E   PP    PS   T A  T    P             V  +       P+E L   P
Sbjct: 1545 KEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELL--IP 1602

Query: 1445 ELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADAR 1504
                +P P +  +    TP   + G +T   K        G+P  T PPV P        
Sbjct: 1603 PAVTSPSPKEAPTPPAVTPPSPEKGPATPAPK--------GTP--TSPPVTP-------- 1644

Query: 1505 ALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKP-RQSPLTYEDHGAPFAGHLPR 1563
                     SLK  P   S +  +   GA V     G P ++ P   ++         P 
Sbjct: 1645 --------SSLKDSP--TSPASVTCKMGATVPQASKGLPAKKGPTALKE---VLVAPAPE 1691

Query: 1564 GSPVTTREPT---PRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE- 1619
             +P+ T  PT   P+ ++ S +S     D     + +  +K P STV    P P+ P + 
Sbjct: 1692 STPIIT-APTRKGPQTKKSSATSPPICPD----PSAKNGSKGPLSTVA---PAPLLPVQK 1743

Query: 1620 HLLRGVSGVDLYRSHIPLA-FDPTSIPRGIPLDAAA 1654
               +   G D   SH P     P       PL AAA
Sbjct: 1744 DSSKTAKGKD--ASHSPKGPLAPPESKASTPLTAAA 1777



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 105/417 (25%), Positives = 147/417 (35%), Gaps = 67/417 (16%)

Query: 684  KKAPAAASEEAA--FPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEV---PRGECSG 738
            KKAPA  +   A   P V+     E      +  + +     L +        P+     
Sbjct: 1491 KKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIP 1550

Query: 739  PA-TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATL-----GADGP-----PPGPPTPPP 787
            PA TV +   T +IP+P    A  + +    PPA       GA  P     PP   +P P
Sbjct: 1551 PAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSP 1610

Query: 788  EDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPA 847
            ++ P P   TP S   G  TP  AP      PPV P   K+  T+ A    +     P A
Sbjct: 1611 KEAPTPPAVTPPSPEKGPATP--APKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQA 1668

Query: 848  AEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 907
            ++ L                  A++GP   K+   A A     +             TA 
Sbjct: 1669 SKGLP-----------------AKKGPTALKEVLVAPAPESTPI------------ITAP 1699

Query: 908  SSGAPQDSDSSATCSADEVD-EAEGGDKNRLLSPRPSLLTPTGDPR--------ANASPQ 958
            +   PQ   SSAT      D  A+ G K  L +  P+ L P             A+ SP+
Sbjct: 1700 TRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPK 1759

Query: 959  KPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPP-----APPPPQNLQPESD-APQ 1012
             PL   + K           KV   P   +    P+PP     AP P   L P+    P 
Sbjct: 1760 GPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPS 1819

Query: 1013 QPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEA----QKLPGDPPCWTSGLPFPVP 1065
             PG      S+ P  PAD++   P+  P   +        L   P   ++G+P P P
Sbjct: 1820 SPGLVLESPSK-PLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTP 1875



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 377/1696 (22%), Positives = 534/1696 (31%), Gaps = 338/1696 (19%)

Query: 733  RGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKP-PATLGADGPPPGPPTPPPEDIP 791
            +G  S PA ++ S  T+S+P   T + K  G N P   P +LG+   P    +     + 
Sbjct: 267  KGPVSPPAALSLS--TQSLPVV-TSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLL 323

Query: 792  APTEPTPASEAT-------GAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQK 844
              T P+  S+ T        + T    P   S  PP+  + E    T AA PV      K
Sbjct: 324  GQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDK 383

Query: 845  PPA---------AEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEK 895
             P+         +  L V T  +  P  S   + +              AT    L A+ 
Sbjct: 384  GPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPN------------ATYHYPLVAQM 431

Query: 896  KEGGSGRATTAKSS-----GAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGD 950
                 G      ++      AP  +   ATC                +SP  S       
Sbjct: 432  PVSSVGTTPLVVTNPCTIAAAPTTTFEVATC----------------VSPPMS-----SG 470

Query: 951  PRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTK-PAPPAPPPPQNLQ---- 1005
            P +N  P  P         A  + P+  K  EP  + A   + P  P  P P++L+    
Sbjct: 471  PISNIEPTSPA--------ALVMAPVAPK--EPSTQVATTLRIPVSPPLPDPEDLKNLPS 520

Query: 1006 ------PESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTS- 1058
                  P     Q   +S  G   SPA       + P   P   A  +  P      +S 
Sbjct: 521  SVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSP 580

Query: 1059 ---------------GLPFPVPPREVIKASPHAPDPSAF-----SYAPPGHPLPLGLHDT 1098
                           G P P+        SP   + SA      SYA P    PL     
Sbjct: 581  EIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSL 640

Query: 1099 ARPVLPRPPTISNPPPLIS--SAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVT 1156
              P +   P  S  P  ++  +AK  S          +G +V L  P +   K   G +T
Sbjct: 641  ITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEG-TVSL-APKNHPVKE--GTLT 696

Query: 1157 MGLPLPMDPKKLAPFSGVKQEQLSPRGQA--GP--PESLGVPTAQEASVLRGTALGSVPG 1212
              LPL     +  P +   Q   +P       P  P+S+  P+   A        G+ PG
Sbjct: 697  T-LPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPA--------GTPPG 747

Query: 1213 GSITKGIPSTRVPSDSAITYRGSITH--GTPADVLYKGTITRIIGEDSPSRLDRGREDSL 1270
                 GI  T   +  A + +   T   G  A    KGT+T +   DSPS L        
Sbjct: 748  TKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLA--DSPSPL-------- 797

Query: 1271 PKGHVIYEGKKGHVLSYEGGMSVTQCSKEDG--RSSSGPPHETAAPKRTYDMMEGRVGRA 1328
                               G+SV+  +K     + S+GP             +E      
Sbjct: 798  -------------------GVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASF-LP 837

Query: 1329 ISSASIEGLMGRAIPPERHSPHHLKEQHHIRGS-ITQGIPRSYVEAQEDYLRREAKLLK- 1386
             +S S +G   +  P   HSP     +     S +T   P+      ++        L  
Sbjct: 838  ENSLSFQG--SKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPF 895

Query: 1387 -REGTPPPPP---PSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRH 1442
             +EG   P P   P+  +T +   +A    +  PA +G+ A+    G             
Sbjct: 896  PKEGPATPAPKQAPALSMTSSSPKKA----RATPAPKGIPASPSPKGAP----------- 940

Query: 1443 TPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMAD 1502
            TP     P P K G  T          A+T  S K       G P    P   P    A 
Sbjct: 941  TPPAATPPSP-KGGPATPSPKWAPTPPAATPPSPK-------GGPATPSPKGAPTPPAAT 992

Query: 1503 ARALERACYEESLKSRPGTASSSGGSIARGAPVIVPEL--GKPRQSPLTY---------- 1550
                       S K  P T S  G   A   P + P    G P  +P             
Sbjct: 993  P---------PSPKGGPATPSPKG---APTPPAVTPPSPKGSPAATPFPKGASTPPAATP 1040

Query: 1551 -EDHGAPFAGHLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPE 1609
                G+P A  LP+G+P T     P  + G  + S         +TP      P +  P+
Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK 1100

Query: 1610 HHPHPISPYEHLLRGVSGVDLYRS--HIPLAFDP-------TSIPRGIPLDAAAAYYLPR 1660
              P P +      +G      ++     P A  P       T  P+G P   AA    P+
Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1160

Query: 1661 -HLAP-----NPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAATAMAQRA 1714
              LA       PT P   PP    G    A    +        T        AT   + A
Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGG---LATPSPKGAPTTPAATPPSPKGGLATPSPKGA 1217

Query: 1715 DMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTP-GTPATAMDRLAYLPTAPQ 1773
                  +P      L     P+G       P  P   PP+P G PAT   + A  P A  
Sbjct: 1218 PTTPAATPPSPKGGL-ATPSPKG------APTTPAATPPSPKGGPATPPPKGAPTPPAAT 1270

Query: 1774 PFSSR-------HSS-------SPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREK 1819
            P S +       H         +P SP G    + P    +         +        K
Sbjct: 1271 PPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPK 1330

Query: 1820 SILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSR------PA---SHSHAHQHSPI 1870
               T       +P    GT     ++ SS GG  + S       PA   SH      +P 
Sbjct: 1331 GAPTPPAVTPPSP---KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPP 1387

Query: 1871 SPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS--PVRPAATFP------P 1922
            SP+   A+        +  +  +     P+TP      +T S   + P A  P      P
Sbjct: 1388 SPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAP 1447

Query: 1923 ATHCPLGGTL------DGVYPTLMEPVLLPKEAP---RVARPERPRADTGHAFLAKPPAR 1973
            AT  P GG        D   P +  P   PKE P   +VA    P+           P  
Sbjct: 1448 ATSAPKGGPATPSSKGDPTLPAVTPP--SPKEPPAPKQVATSSSPKKAPATPAPMGAPTL 1505

Query: 1974 SGLEPASSPSKGSEPRPLVPPVSGHATI--ARTPAKNLAPHHA-------------SPDP 2018
              + P+S     + P     P++  AT+   +TPA  LAP  A             +P  
Sbjct: 1506 PAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPA-TLAPKEALIPPAMTVPSPKKTPAI 1564

Query: 2019 PAPPASASDPHREKTQSKPF----------SIQELELRSLGYHGS---SYSPEGVEPVSP 2065
            P P  + + P  ++  S P           S +EL +       S   + +P  V P SP
Sbjct: 1565 PTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSP 1624

Query: 2066 VSSPSLTHDKGLPKHLEELDKSHLEGELRP--------------KQPGPVKLGGEAAHLP 2111
               P+    KG P        S  +    P               +  P K G  A    
Sbjct: 1625 EKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEV 1684

Query: 2112 HLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQ--LSAPLPAP 2169
             + P PES P     + TAP  KG Q   + A   S  I  D +  +  +  LS   PAP
Sbjct: 1685 LVAPAPESTP-----IITAPTRKGPQTKKSSA--TSPPICPDPSAKNGSKGPLSTVAPAP 1737

Query: 2170 LYSFPGASCPVL---DLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGE 2226
            L      S       D    P     PP    +    +   E  K  P+P   SV     
Sbjct: 1738 LLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFE--KVLPKPESASVSAAPS 1795

Query: 2227 DGIE-PVSPPEGMTEP 2241
              +  P++P    T P
Sbjct: 1796 PPVSLPLAPSPVPTLP 1811



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 133/567 (23%), Positives = 179/567 (31%), Gaps = 120/567 (21%)

Query: 1733 AGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSS--PLSPGGPT 1790
            + P   ++ S +P   +    +  +PAT      + PT P P  +   S+  PLSP G T
Sbjct: 825  SSPVSPVEASFLPENSLSFQGSKDSPATT-----HSPTPPSPKGAPTPSAVTPLSPKGVT 879

Query: 1791 HLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGG 1850
               K T T S                           V + P  + G    +     +  
Sbjct: 880  LPPKETPTPS---------------------------VVNLPFPKEGPATPAPKQAPALS 912

Query: 1851 GGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTST 1910
               SS + A  + A +  P SP  + A    P        KG      P+TP+       
Sbjct: 913  MTSSSPKKARATPAPKGIPASPSPKGA--PTPPAATPPSPKG-----GPATPS-----PK 960

Query: 1911 SSPVRPAATFP-----PATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHA 1965
             +P  PAAT P     PAT  P G       P    P   PK  P  A P    A T  A
Sbjct: 961  WAPTPPAATPPSPKGGPATPSPKGAPTP---PAATPPS--PKGGP--ATPSPKGAPTPPA 1013

Query: 1966 FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASA 2025
                PP+  G   A+   KG+   P   P S   + A TP    AP   +   P+P    
Sbjct: 1014 --VTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGP 1071

Query: 2026 SDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELD 2085
            + P  +                      + +P    P SP   P+    KG P       
Sbjct: 1072 ATPSLK---------------------GAPTPPAATPPSPKGGPATPSPKGAPMPPAATP 1110

Query: 2086 KSHLEGELRPKQPG---------PVKLGGEAAHLPHLRP-LPESQPSSSPLLQTAPGVKG 2135
             S   G   P   G         P   GG A   P   P  P + P S       P  KG
Sbjct: 1111 PSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKG 1170

Query: 2136 HQRVVTLAQHISEVITQDYTRHHPQ-QLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPP 2194
                           T   T   P+  L+ P P    + P A+ P      P   L  P 
Sbjct: 1171 ------------APTTPAATPPSPKGGLATPSPKGAPTTPAATPP-----SPKGGLATPS 1213

Query: 2195 PDHG--APARGSPHSEGGKRSPE----PNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAV 2248
            P      PA   P  +GG  +P     P   +       G     PP+G   P     A 
Sbjct: 1214 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTP----PAA 1269

Query: 2249 YPLLYRDGEQTEPSRMGSKSPGNTSQP 2275
             P   + G  T P + G+ +P   + P
Sbjct: 1270 TPPSLKGGLATPPHK-GAPNPAVVTPP 1295



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 129/595 (21%), Positives = 188/595 (31%), Gaps = 98/595 (16%)

Query: 1732 AAGPRGIIDLSQVPHLPVLVPPTPGTPATAMD---RLAYLPTAPQPFSSRHSSSPLSPGG 1788
            ++GP   I+ +  P   V+ P  P  P+T +    R+   P  P P   ++  S +    
Sbjct: 468  SSGPISNIEPTS-PAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKF 526

Query: 1789 PTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSS 1848
            PT     T  +S E       +     +++ ++L     V+ AP   P  + +S S    
Sbjct: 527  PTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVL---PLVQAAPKNSPSFQSTSSSPEIP 583

Query: 1849 GGGGGSSSRPASHSHAHQHSPISPRTQD-ALQQRPSVLHNTGMKGIITAVEPSTPTVLRS 1907
                 + ++ +         P S  T    +    SV+      G      P +   L  
Sbjct: 584  LSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAG------PDSAGPLLK 637

Query: 1908 TSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFL 1967
            +S  +P    A FP  +  P G                   AP  A+       T   FL
Sbjct: 638  SSLITPT--VAAFPLESADPAG------------------VAPTTAKGTSTYTTTASPFL 677

Query: 1968 AKPPARSGLEPASSPSKGS--EPRPLVPPVSGHATIARTPAKNLAP----------HHAS 2015
                    L P + P K       PLVP  S +  +A +P    AP            + 
Sbjct: 678  ---EGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSV 734

Query: 2016 PDPPAPPAS--------------------ASDPHREKTQSKPFSIQELELRSLGYHGSSY 2055
            P P  PPA                     AS P    T+    S       +L Y   S 
Sbjct: 735  PSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSP 794

Query: 2056 SPEGVEPVSPVSS--PSLTHDKGLPKHLEELDK--SHLEGELRPKQPGPVKLGGEAAHLP 2111
            SP GV  VSP +   P+     G    +  L    S +E    P+     +   ++    
Sbjct: 795  SPLGVS-VSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATT 853

Query: 2112 HLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQH---ISEVITQDYTRHHPQQLSAPLPA 2168
            H    P  + + +P   T    KG    VTL         V+   + +  P    AP  A
Sbjct: 854  HSPTPPSPKGAPTPSAVTPLSPKG----VTLPPKETPTPSVVNLPFPKEGP-ATPAPKQA 908

Query: 2169 PLYSFPGASCPVLDLRRPPSDLYLPPPDHGA---PARGSPHSEGGKRSPEPNKTSVLGGG 2225
            P  S   +S         P  +   P   GA   PA   P  +GG  +P P         
Sbjct: 909  PALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT---- 964

Query: 2226 EDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMG---SKSPGNTSQPPA 2277
                 P SP  G   P    +   P        T PS  G   + SP     PPA
Sbjct: 965  PPAATPPSPKGGPATPSPKGAPTPP------AATPPSPKGGPATPSPKGAPTPPA 1013



 Score = 39.3 bits (90), Expect = 0.050
 Identities = 51/217 (23%), Positives = 79/217 (36%), Gaps = 43/217 (19%)

Query: 736  CSGPATVNNSSDTESI--PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT--------- 784
            C  P+  N S    S   P+P     KD+ +      A+    GP   P +         
Sbjct: 1717 CPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAA 1776

Query: 785  ------PPPEDIPAPTEPTPASEATGAPTPPPAPPS-----PSAP--------PPVVPKE 825
                  P PE       P+P      AP+P P  P      PS+P         P+ P +
Sbjct: 1777 AFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPAD 1836

Query: 826  EKE-------EETAAAPPVEEGEEQKP-PAAEELAVDTGKAEEPV----KSECTE-EAEE 872
            E E       E  +   P +      P P +  + V T  A++PV    K   TE +++E
Sbjct: 1837 EDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDE 1896

Query: 873  GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSS 909
               + ++ ++ +AT + A  A   E      + AK S
Sbjct: 1897 SVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQS 1933



 Score = 37.7 bits (86), Expect = 0.14
 Identities = 57/215 (26%), Positives = 75/215 (34%), Gaps = 32/215 (14%)

Query: 1018 PRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGD---PPCWTSGLPFPVPPREVIKASP 1074
            P  +   P P A+  A  P+        A   PG    PPC  S  P   P     +ASP
Sbjct: 10   PATEQELPQPQAET-AVLPMSSALSVTAALGQPGPTLPPPC--SPAPQQCPLSAANQASP 66

Query: 1075 HAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQ 1134
              P PS  +  P   P P     TA P+   P   +  P LI     P+ L     A++ 
Sbjct: 67   F-PSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAAL-----ALAS 120

Query: 1135 GMSVQLHVPYSEHAKAPVGPVTMGLP---LPMDPKKLAPFSGVKQEQLSPRGQAGPPESL 1191
             M               + P   G P    P+    LAP S  K     P     PP S+
Sbjct: 121  PM---------------IAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPP-SV 164

Query: 1192 GVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPS 1226
             V  +     L      S P  ++ K +PS  VP+
Sbjct: 165  AVAESGSVITLSAPIAPSEPKTNLNK-VPSEVVPN 198



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 77/321 (23%), Positives = 114/321 (35%), Gaps = 25/321 (7%)

Query: 738  GPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT 797
            G AT    +  + +P P  E A     +     A LG  GP     T PP   PAP +  
Sbjct: 3    GEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGP-----TLPPPCSPAP-QQC 56

Query: 798  PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 857
            P S A  A +P P+P + ++ P  VP  +    TA   P+    E        +      
Sbjct: 57   PLSAANQA-SPFPSPSTIASTPLEVPFPQSSSGTAL--PLGTAPEAPTFLPNLIGPPISP 113

Query: 858  AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 917
            A   + S       +G        A  A A  ++  +K         T+  S A  +S S
Sbjct: 114  AALALASPMIAPTLKGTPSSSAPLALVALAPHSV--QKSSAFPPNLLTSPPSVAVAESGS 171

Query: 918  SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAA-IPPI 976
              T SA         + N++    PS + P  +P+   SP  P  +  +       +  I
Sbjct: 172  VITLSAPIAPSEPKTNLNKV----PSEVVP--NPKGTPSP--PCIVSTVPYHCVTPMASI 223

Query: 977  VTKVHEPPREDAAPTKPAPPAPPPPQNLQPES--DAPQQPGS-SPRGKSRSPAPPADKEA 1033
             + V   P+    PT     A P  ++    S   +PQ PGS S +G    PA  +    
Sbjct: 224  QSGVASLPQ--TTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQ 281

Query: 1034 EKPVFFPAFAAEAQKLPGDPP 1054
              PV   +        P D P
Sbjct: 282  SLPVVTSSQKTAGPNTPPDFP 302



 Score = 36.2 bits (82), Expect = 0.42
 Identities = 50/252 (19%), Positives = 84/252 (33%), Gaps = 44/252 (17%)

Query: 685  KAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNN 744
            K P +    A   PV +D    A G            +A H+    +   E      +  
Sbjct: 1727 KGPLSTVAPAPLLPVQKDSSKTAKG-----------KDASHSPKGPLAPPESKASTPLTA 1775

Query: 745  SSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPED---------IPAPTE 795
            ++  + +P P + +        P PP +L    P P P  PP +          + +P++
Sbjct: 1776 AAFEKVLPKPESASVSAA----PSPPVSLPL-APSPVPTLPPKQQFLPSSPGLVLESPSK 1830

Query: 796  P-TPASEATGAPTPPPAP--------------PSP---SAPPPVVPKEEKEEETAAAPPV 837
            P  PA E    P  PP P              P+P     P P    ++   +       
Sbjct: 1831 PLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGT 1890

Query: 838  EEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKE 897
            E   ++  P  EE        ++   +   E  EE  +K K + + +   +   K   ++
Sbjct: 1891 ESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQ 1950

Query: 898  -GGSGRATTAKS 908
              G  R T  KS
Sbjct: 1951 VTGVTRVTIRKS 1962


>gi|209977084 REST corepressor 3 isoform c [Homo sapiens]
          Length = 449

 Score =  100 bits (250), Expect = 1e-20
 Identities = 86/311 (27%), Positives = 136/311 (43%), Gaps = 41/311 (13%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K+F  I   L  KT+A  V YYY  KK  +  SL+ R  R   
Sbjct: 147 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 203

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545
           K   +  Q       ++  PM  +  +   +KE +KE   E+    V+  K  L      
Sbjct: 204 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 260

Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592
                    + K     G    +++ VA S     AN+  R+       + R + N    
Sbjct: 261 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 320

Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647
             A+  +    +   +  ES+     RWT EE   A +G+ ++G+++ AIA ++G+KTV 
Sbjct: 321 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 380

Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707
           Q KNF+ NY++R NL+E+LQ+     E E+  +     A     E  +   V        
Sbjct: 381 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 429

Query: 708 SGVSGNEEEMV 718
           SG S +EEE V
Sbjct: 430 SGKSTDEEEEV 440


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 167/779 (21%), Positives = 285/779 (36%), Gaps = 106/779 (13%)

Query: 293  QWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQS 352
            Q E+ F  R D+L EA   KV    N    R+ + ++ EY          +R+LQ R   
Sbjct: 288  QSEEWFRVRLDRLSEA--AKV----NTDAMRSAQEEITEY----------RRQLQARTTE 331

Query: 353  RVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINM 412
                + +  S+   RSE E     D  S QE +++             DA+ +  K+   
Sbjct: 332  LEALKSTKDSLERQRSELEDRHQADIASYQEAIQQ------------LDAELRNTKWE-- 377

Query: 413  NGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQH-------PKNFGLIASFLERKTVAE 465
               MA  ++ Y+D   + M  + E   +R+            P  F L     +  +V+ 
Sbjct: 378  ---MAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVST 434

Query: 466  CVLY-----YYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEK 520
             +         + +K+E    +V         +++  ++++++ ++++ +      +EE 
Sbjct: 435  HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494

Query: 521  DEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKG 580
            +  E+E ++   EE    E + +  +KE+    +   + EKE   S     +  + +   
Sbjct: 495  EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554

Query: 581  RITRSMANEANSEEAITPQQSAELASMELNESSRWTE-------EEMETAKKGLLEHGRN 633
            +       EA S E    +  AE+ S E  +S    E       +  E AK  + E  ++
Sbjct: 555  KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614

Query: 634  WSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKM-EKERNARRKKKKAPA---A 689
             +     V  +  S  +       K    +E     K K  EKE     +K K+P    A
Sbjct: 615  PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 690  ASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTE 749
             S E A  PV  + +      S  +EE     +A      E    E +       +   E
Sbjct: 675  KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734

Query: 750  SIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP 809
               SP  E AK + +    P      D   P   TP  E+  +P +  P  E   +P   
Sbjct: 735  KAKSPVKEEAK-SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP--EKAKSPVKE 791

Query: 810  PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEE 869
                   A  P+     KE+  A    + + EE K P  EE      K +EP K     E
Sbjct: 792  EVKSPEKAKSPL-----KEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK---AE 843

Query: 870  AEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEA 929
             E+ PA  K  E  ++  E   +A KKE    +    K     +  +S       E  + 
Sbjct: 844  EEKAPATPKTEEKKDSKKE---EAPKKEAPKPKVEEKKEPAVEKPKESKV-----EAKKE 895

Query: 930  EGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDA- 988
            E  DK ++         PT +  A A  +   D K         P   T+V +   +DA 
Sbjct: 896  EAEDKKKV---------PTPEKEAPAKVEVKEDAK---------PKEKTEVAKKEPDDAK 937

Query: 989  --APTKPAPPAPPPPQNLQPESDAPQQPGSSPRGK----------SRSPAPPADKEAEK 1035
               P+KPA      P+    + +  ++P   P+ +          S+ P+ P  ++AEK
Sbjct: 938  AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEK 996



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 109/425 (25%), Positives = 166/425 (39%), Gaps = 51/425 (12%)

Query: 670  KLKMEKERNARRKKKKAPAAASEEA----AFPPVVEDEEMEASGVSGNEEEMVEEAEALH 725
            K+K E++     K +K      E+         V E+EE EA    G EEE  EE EA  
Sbjct: 437  KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA-- 494

Query: 726  ASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGP-----PP 780
              G E    E   P     +S  +   SP  E AK   +   K P    A  P     P 
Sbjct: 495  EGGEE----ETKSPPAEEAASPEKEAKSPVKEEAKSPAE--AKSPEKEEAKSPAEVKSPE 548

Query: 781  GPPTPPPEDIPAPTEP-TPASEATGAPTPPPAPP---SPSAPPPVVPKEEKEEETAAAPP 836
               +P  E+  +P E  +P  E   +P    +P    SP+      P E K  E A +P 
Sbjct: 549  KAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV 608

Query: 837  VEEGE---EQKPPAAEELAVDTGKAEEPVKSEC-TEEAEEGPAKGKDAEAAEAT----AE 888
             EE +   E K P  EE A    + + P K++  T+E  + P K K  E  EA     A+
Sbjct: 609  KEEAKSPAEAKSPVKEE-AKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK 667

Query: 889  GALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSP-------R 941
              +KAE K     ++     + +P+ + S     A   ++A+   K    SP       +
Sbjct: 668  SPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK 727

Query: 942  PSLLTP----------TGDPRANASPQ--KPLDLKQLKQRAAAIPPIVTKVHEPPREDAA 989
                TP             P    SP+  K LD+K  + +  A     +   + P +  +
Sbjct: 728  EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787

Query: 990  PTKPAPPAPPPPQN-LQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQK 1048
            P K    +P   ++ L+ ++ AP++     + + +SP    +K  E  V  P   AE +K
Sbjct: 788  PVKEEVKSPEKAKSPLKEDAKAPEKE-IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846

Query: 1049 LPGDP 1053
             P  P
Sbjct: 847  APATP 851



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 107/575 (18%), Positives = 220/575 (38%), Gaps = 59/575 (10%)

Query: 79  SQELHLRPESHSYLPELGKSEME--FIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLT 136
           S   H++ +S   +  + KSE E   +E +    ++  +            +    E   
Sbjct: 431 SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGE 490

Query: 137 KDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKK 196
           ++ +  G+ E  SPP+     PE E   P   + +        ++E      ++   +K 
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550

Query: 197 QQQLEEEAAKPPE---PEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGP--- 250
           +   +EEA  PPE   PEK  +  P E K     +    E  K    A    +   P   
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610

Query: 251 ------QVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQ 304
                 + + P+  +     +     K     +++     K ++  ++  E K  ++   
Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE--EAKSPEKAKS 668

Query: 305 LMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMS 364
            ++A  K  E+ ++  +  AK        EK    ++++ +  E+ +S V +        
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSP------EKAKSPVKEEAKSPEKAKSPVKE-------E 715

Query: 365 AARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYK 424
           A   E   S + +     E  +  +++ A  P        ++ K +++    A      +
Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA--KSPEKAKTLDVKSPEAKTPAKEE 773

Query: 425 DRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVR 484
            R   + + E+ K   +E+     K      S L+    A         +K    K  V+
Sbjct: 774 ARSPADKFPEKAKSPVKEEVKSPEK----AKSPLKEDAKA--------PEKEIPKKEEVK 821

Query: 485 RSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKE- 543
              +   K Q+ + ++  ++ ++++ P    ++E+KD K KE+  +KE  KP+VE  KE 
Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSK-KEEAPKKEAPKPKVEEKKEP 880

Query: 544 ----------DLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSE 593
                     +  KE+ +D       EKEA A K     +++ + K  + +   ++A ++
Sbjct: 881 AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA-KVEVKEDAKPKEKTEVAKKEPDDAKAK 939

Query: 594 EAITPQQSAELASMELN---ESSRWTEEEMETAKK 625
           E   P +  E A  + +   E ++  EE+ +T  K
Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK 974



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 83/416 (19%), Positives = 145/416 (34%), Gaps = 53/416 (12%)

Query: 473  TKKNENYKSLVRRSYRRRGKSQQQQQ---QQQQQQQQQQQQPMPRSSQEEKDEKEKEKEA 529
            TK+        +   +   KS ++ +   + + +  ++ + P+   ++  +  K   KE 
Sbjct: 642  TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701

Query: 530  EKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANE 589
             K  EK +    +E    EK      E+    E   S  ++ A S  + K    ++   +
Sbjct: 702  AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP-EKAKTLD 760

Query: 590  ANSEEAITP--QQSAELASMELNESSRWTEEEM---ETAKKGLLEHGRNWSAIARMVGSK 644
              S EA TP  +++   A     ++    +EE+   E AK  L E  +           K
Sbjct: 761  VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK--------APEK 812

Query: 645  TVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNA-------RRKKKKAPAAASEEAAFP 697
             + + +      K+ +   E+  +   K  +E  A        +K  K   A  +EA  P
Sbjct: 813  EIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP 872

Query: 698  PVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTE 757
             V   EE +   V   +E  VE  +       +VP  E   PA V    D +  P   TE
Sbjct: 873  KV---EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK--PKEKTE 927

Query: 758  AAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSA 817
             AK                          P+D  A     PA +   AP         + 
Sbjct: 928  VAKKE------------------------PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK 963

Query: 818  PPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEG 873
             P   PK E + +       +E  + K   AE+ +    K  +P +    ++A +G
Sbjct: 964  KPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 129/565 (22%), Positives = 200/565 (35%), Gaps = 97/565 (17%)

Query: 1772 PQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHA 1831
            P PFS      P  P   TH+   +       E+        + + E++ +T   T E  
Sbjct: 417  PIPFSLPEGL-PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE 475

Query: 1832 PIWRP--GTEQSSGSSGSSGGGGGSS-SRPASHSHAHQHSPISPRTQDALQQRPSVLHNT 1888
               +   G E+  G    + GG   + S PA  + + +    SP  ++A  + P+   + 
Sbjct: 476  KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA--KSPAEAKSP 533

Query: 1889 GMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKE 1948
              +   +  E  +P         SP +  A  PP    P             E    P E
Sbjct: 534  EKEEAKSPAEVKSPE-----KAKSPAKEEAKSPPEAKSPE-----------KEEAKSPAE 577

Query: 1949 APRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKN 2008
               V  PE+          AK PA+   E A SP++   P     PV      A++PA+ 
Sbjct: 578  ---VKSPEK----------AKSPAK---EEAKSPAEAKSPEKAKSPVKEE---AKSPAEA 618

Query: 2009 LAPHHASPDPPA---PPASASDPHREKTQS--KPFSIQELELRSLGYHGSSYSPEGVEP- 2062
             +P       PA    P  A  P +E+ +S  K  S ++ E +S     S    E   P 
Sbjct: 619  KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE 678

Query: 2063 --VSPVSSPSLTHDKGLPKHLEELD-----KSHLEGELR--PKQPGPVKLGGEAAHLPHL 2113
               SPV + + + +K      EE       KS ++ E +   K   PVK   E A  P  
Sbjct: 679  KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK---EEAKTPEK 735

Query: 2114 RPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSF 2173
               P  + + SP    +P     ++  TL     E  T       P +  A  PA    F
Sbjct: 736  AKSPVKEEAKSPEKAKSP-----EKAKTLDVKSPEAKT-------PAKEEARSPAD--KF 781

Query: 2174 P-GASCPVLDLRRPPSDLYLP-PPDHGAPARGSPHSE----GGKRSPEPNKTSVLGGGED 2227
            P  A  PV +  + P     P   D  AP +  P  E      K   +P +  V    + 
Sbjct: 782  PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK 841

Query: 2228 GIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTE-PSRMGSKSPGNTSQPPAFFSKLTESN 2286
              E  +P    TE             +D ++ E P +   K      + PA    + +  
Sbjct: 842  AEEEKAPATPKTEE-----------KKDSKKEEAPKKEAPKPKVEEKKEPA----VEKPK 886

Query: 2287 SAMVKSKKQEI--NKKLNTHNRNEP 2309
             + V++KK+E    KK+ T  +  P
Sbjct: 887  ESKVEAKKEEAEDKKKVPTPEKEAP 911



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 62/265 (23%), Positives = 112/265 (42%), Gaps = 17/265 (6%)

Query: 93  PELGKSEMEFIESKRPRLELLPDPLLRPSPLLATG-QPAGSEDLTKDRSLT-GKLEPVSP 150
           PE  KS ++  E+K P     P      SP  A   + A + D+    + T  K E  SP
Sbjct: 719 PEKAKSPVKE-EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777

Query: 151 ----PSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAK 206
               P    +  + E+  P  +K  L ++    ++EI   E+  S +K++++  E +  +
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837

Query: 207 PP---EPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDT 263
           PP   E EK  + P  E K  S      +E  KK     ++ E   P VE P  ++    
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSK----KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893

Query: 264 RQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWE--KKVERIENNPR 321
           ++  E+ K      K+     + +  A+ + + +  ++     +A E  K  E+ E  P 
Sbjct: 894 KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE 953

Query: 322 RR-AKESKVREYYEKQFPEIRKQRE 345
           ++  KE K ++  EK   E + + +
Sbjct: 954 KKDTKEEKAKKPEEKPKTEAKAKED 978



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 43/206 (20%), Positives = 83/206 (40%), Gaps = 14/206 (6%)

Query: 54  SPGSIIQPQRRRPSLLSEFQ-PGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLEL 112
           SP  +  P++ +     E + P   +S E     ++ S + E  KS  E   +K P  E 
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPE-----KAKSPVKEEAKSPAE---AKSPVKEE 625

Query: 113 LPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEEL 172
              P    SP  A   P   E  + +++ + + E    P    +  + E   P  +K  +
Sbjct: 626 AKSPAEVKSPEKAKS-PTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684

Query: 173 IQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPV---SPPPIESKHRSLVQI 229
                  ++  + V+++    +K +  ++EEA  P + + PV   +  P ++K     + 
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744

Query: 230 IYDENRKKAEAAHRILEGLGPQVELP 255
              E  K  E A + L+   P+ + P
Sbjct: 745 KSPEKAKSPEKA-KTLDVKSPEAKTP 769


>gi|27734799 REST corepressor 2 [Homo sapiens]
          Length = 523

 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 100/408 (24%), Positives = 167/408 (40%), Gaps = 42/408 (10%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K F  I   L  K +   V YYY  KK  +  S++ R  RR G
Sbjct: 135 WTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLG 194

Query: 492 KSQQQQQQQQQQQQQ---QQQQPMPRSSQEEK-DEKEKEKEAEKEEEKPEVENDKEDLLK 547
             + ++   + ++ +    + +P P   + E    +         +++ +V   +   L+
Sbjct: 195 GRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLR 254

Query: 548 EKTDDTSGEDNDEKEAVASKGR--------KTANSQGRRKGRITRSMANEANS-----EE 594
            +     G     +   A  G         +  +SQ     R  +SM    +S     E 
Sbjct: 255 TRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEG 314

Query: 595 AITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYF 654
            I P +  E A+ + N  SRWT +E   A + +  +G+++ AIA ++G+KT++Q K F+ 
Sbjct: 315 GIDPLRPPE-ANTKFN--SRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFV 371

Query: 655 NYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNE 714
           +Y++R NL+E+LQ+ + + +    A    ++A   A   A  P + ED+E++ + VS + 
Sbjct: 372 SYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPA--PALEEDDEVQITSVSTSV 429

Query: 715 EEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLG 774
                           VP      P   + S     +  P   A     Q    PP   G
Sbjct: 430 P-------------RSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQ---PPPLQQG 473

Query: 775 ADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPP----APPSPSAP 818
               P   P  PP  +  P    P   A   P PPP    AP  P AP
Sbjct: 474 RFLQPRLAPNQPPPPLIRPALAAPRHSARPGPQPPPTLIGAPLEPPAP 521



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 3/95 (3%)

Query: 757 EAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPP-SP 815
           EA +D     P P        P P P     +++   +  T    +     PPP PP S 
Sbjct: 387 EAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSL 446

Query: 816 SAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAA 848
           S PPP++  P           PP+++G   +P  A
Sbjct: 447 SQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLA 481



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 37/143 (25%), Positives = 56/143 (39%), Gaps = 27/143 (18%)

Query: 954  NASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPT-----KPAPPAPPPPQNLQ--- 1005
            + +P  P+ +++ ++ A    P + +  E      + +      PAPP PPPP +L    
Sbjct: 391  DGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPP 450

Query: 1006 -----PESDAP---QQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWT 1057
                 P   AP   +QP    +G+   P   A  +   P+  PA AA             
Sbjct: 451  PLLRPPLPTAPTLLRQPPPLQQGRFLQPR-LAPNQPPPPLIRPALAAPRH---------- 499

Query: 1058 SGLPFPVPPREVIKASPHAPDPS 1080
            S  P P PP  +I A    P PS
Sbjct: 500  SARPGPQPPPTLIGAPLEPPAPS 522



 Score = 32.3 bits (72), Expect = 6.1
 Identities = 20/51 (39%), Positives = 23/51 (45%), Gaps = 11/51 (21%)

Query: 1066 PREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPT-ISNPPPL 1115
            PR V  A P  P P++ S  PP            RP LP  PT +  PPPL
Sbjct: 430  PRSVPPAPPPPPPPTSLSQPPP----------LLRPPLPTAPTLLRQPPPL 470


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 180/807 (22%), Positives = 279/807 (34%), Gaps = 165/807 (20%)

Query: 432  WSEQEKETFREKFMQHPKNFGLIAS-FLERKTVAECVLYYYLTKKN-ENYKSLVRRSYRR 489
            W+E E + F +   Q+ KNF  I    L  K   E + +YY  KK  E   S   R +RR
Sbjct: 396  WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRR 455

Query: 490  RGKSQQQQQQQQQQQQQQQQQP-------MPRSSQEEKDEKEKEKEAE------------ 530
            +   ++ + +          +P       +  +S+++ D ++ E+E +            
Sbjct: 456  QAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTS 515

Query: 531  ----------------------KEEEKPEVENDKEDL------LKEKTDDTSGEDNDEKE 562
                                  K  E P +E   +        +KE+ D  SG+ +    
Sbjct: 516  KDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTR 575

Query: 563  AVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAELASMELNESSRWTEEEME 621
               S+G  +    GR+K   +     +  N +   + + S   AS   N+S      + E
Sbjct: 576  R--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDS------KAE 627

Query: 622  TAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARR 681
            T KK            A+ V  +  S  K+      KRQ       + K+  + E   R 
Sbjct: 628  TVKKS-----------AKKVKEEASSPLKS-----NKRQ-------REKVASDTEEADRT 664

Query: 682  KKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPAT 741
              KK     ++E + P    + E E+S           ++ +++  G+  P+        
Sbjct: 665  SSKKTK---TQEISRPNSPSEGEGESS-----------DSRSVNDEGSSDPKD-----ID 705

Query: 742  VNNSSDTESIPSPH-TEAAKDTGQNGP----KPPATLGADGPPPGPPTPPPEDIPAPTE- 795
             +N S + SIPSP   E+  D+         +PPA     G  P P + PP     PT  
Sbjct: 706  QDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG 765

Query: 796  PTPASEAT---GAPTPPPAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQKPPAAEE 850
            PTP++ A    G+PT   AP  P AP   VP    ++  A  P  P        P     
Sbjct: 766  PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPP 825

Query: 851  LAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAE---------KKEGGSG 901
            L   TG A +P          + P  G+      +   G L              +   G
Sbjct: 826  LQPLTGSAGQP----SAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQG 881

Query: 902  RATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPL 961
            +A    S  A     S    ++    +++   + + L P P  +     P     PQ P 
Sbjct: 882  QAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPA 941

Query: 962  DLKQLKQRAAAIP-PIVTKVHEPPREDAAP-----TKPAPPAPPPPQNLQPESDAPQQPG 1015
                      + P P     + PP     P     T   P A PPP  L P+S       
Sbjct: 942  PQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSP 1001

Query: 1016 SSPRGKSRS---PAPPAD-------KEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVP 1065
            + P G ++S   P PPA        + A +P F     A+   +PG PP  T   P   P
Sbjct: 1002 AQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPF-----AQHPFVPGGPPPIT---PPTCP 1053

Query: 1066 PREVIKASP--HAPDPSAFSYAPPGH-------PLPL------GLHDTARPVLPRPP--T 1108
                  A P   A  P + + A  G        PLP        L D   P  P PP  +
Sbjct: 1054 STSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRS 1113

Query: 1109 ISNPPPLISSAKHPSVLERQIGAISQG 1135
             S  P ++ +  H S   R    + +G
Sbjct: 1114 PSPEPTVVDTPSHASQSARFYKHLDRG 1140



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%)

Query: 1802 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1861
            ERER++++E++R+RERE+                   E    +  SS    G  S P   
Sbjct: 1181 EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 1223

Query: 1862 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1920
               H      P         P +  +T    + T  E + P V+  T+ + P   P    
Sbjct: 1224 GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 1281

Query: 1921 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1977
             P  A H P    L  V PT+ E  L  +E   R  R    R      F  KPP    L 
Sbjct: 1282 DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 1338

Query: 1978 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2034
            PA++P +         +PP +G             PH  AS  P   P           Q
Sbjct: 1339 PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 1385

Query: 2035 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2094
             +P       L +   H    +    +P++ +   ++T     P H +    SH+   L 
Sbjct: 1386 LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 1437

Query: 2095 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2152
              Q  P+  G      P + PL     ++ P L   P   G      L Q  H  E++  
Sbjct: 1438 LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 1492

Query: 2153 D-YTRHHPQQLSAPLPAPL 2170
              +   +P+ L   +P P+
Sbjct: 1493 PVFGTPYPRDLPGAIPPPM 1511



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%)

Query: 1405 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1463
            K +A  PLK  K   E + +  +EA R+  +  + +    P  P       EG  +    
Sbjct: 637  KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 692

Query: 1464 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1522
            +  D G+S       D RS       T P +  P D  +D+   + +  ++ L+++P   
Sbjct: 693  VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 741

Query: 1523 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1576
             +  G       AP   P+L  P  +P        G+P A   P   P     P P    
Sbjct: 742  QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 800

Query: 1577 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1610
             Q  +L   +                + LT +  + +   H+  P H             
Sbjct: 801  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 860

Query: 1611 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1660
                HP P  P+    +   G     +    A+  TS+       A  +   PR      
Sbjct: 861  PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 920

Query: 1661 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1705
                  H+ P PT P         H +PP+L    P +             ++S   HH 
Sbjct: 921  APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 979

Query: 1706 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1765
              +A      ++    P  SS      A P G   L+Q  +LP   PP    P T + ++
Sbjct: 980  PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 1028

Query: 1766 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1825
            A     PQP  ++H   P  PGGP  +T PT  S+S                        
Sbjct: 1029 A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 1056

Query: 1826 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1869
                  P   PGT      SG++  GG   G SS P             A    +    P
Sbjct: 1057 -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 1111

Query: 1870 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1929
             SP  +  +   PS  H +        ++    +  R+     P+              G
Sbjct: 1112 RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 1156

Query: 1930 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1974
              L       +E     +EA + AR ER R                +   A  A   A  
Sbjct: 1157 SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 1214

Query: 1975 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2019
            G      L          EP P     VPP  G  T A RT ++   PH  SP     P 
Sbjct: 1215 GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 1274

Query: 2020 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2060
              P + +DP                  RE  + + +   I+E ELR     G    P  +
Sbjct: 1275 YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 1334

Query: 2061 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2101
            +P+ P ++P        +LT       H        L  L++  L     +LRP+   P 
Sbjct: 1335 DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 1394

Query: 2102 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2159
            +L  E  H   +  L     +   +    P    H  + + L  H  + + Q      HP
Sbjct: 1395 RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 1454

Query: 2160 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2189
                L+A      + +P  + P   L +PP +
Sbjct: 1455 LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 1486



 Score = 39.7 bits (91), Expect = 0.038
 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%)

Query: 1969 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2028
            K  A+   E ASSP K S  R      S      RT +K       S      P S S+ 
Sbjct: 630  KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 683

Query: 2029 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2088
              E + S          RS+   GSS  P+ ++  +  +SPS+      P+  E    S 
Sbjct: 684  EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 728

Query: 2089 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2148
             + ++   QP  ++          + P P S P  +P L T         V         
Sbjct: 729  AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 779

Query: 2149 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2208
              T     + PQ  +AP+P           P L  +RPPS    P P    P +    S 
Sbjct: 780  --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833

Query: 2209 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2268
            G   +P   +  + G G  G   +     +  PG  +    P     G+    +   +  
Sbjct: 834  GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 893

Query: 2269 PGNTSQPPAFFSKL 2282
            P  + Q PA  S L
Sbjct: 894  PHTSLQLPASQSAL 907



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 12/24 (50%), Positives = 19/24 (79%)

Query: 1796 TTTSSSERERDRDRERDRDREREK 1819
            T     ++++++DR+RDRDREREK
Sbjct: 2    TADKDKDKDKEKDRDRDRDREREK 25



 Score = 32.0 bits (71), Expect = 7.9
 Identities = 12/45 (26%), Positives = 28/45 (62%)

Query: 491  GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535
            G    +++++  ++ +++ +   R  +E + EKEKE+E E+E E+
Sbjct: 1156 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 1200


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 180/807 (22%), Positives = 279/807 (34%), Gaps = 165/807 (20%)

Query: 432  WSEQEKETFREKFMQHPKNFGLIAS-FLERKTVAECVLYYYLTKKN-ENYKSLVRRSYRR 489
            W+E E + F +   Q+ KNF  I    L  K   E + +YY  KK  E   S   R +RR
Sbjct: 396  WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRR 455

Query: 490  RGKSQQQQQQQQQQQQQQQQQP-------MPRSSQEEKDEKEKEKEAE------------ 530
            +   ++ + +          +P       +  +S+++ D ++ E+E +            
Sbjct: 456  QAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTS 515

Query: 531  ----------------------KEEEKPEVENDKEDL------LKEKTDDTSGEDNDEKE 562
                                  K  E P +E   +        +KE+ D  SG+ +    
Sbjct: 516  KDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTR 575

Query: 563  AVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAELASMELNESSRWTEEEME 621
               S+G  +    GR+K   +     +  N +   + + S   AS   N+S      + E
Sbjct: 576  R--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDS------KAE 627

Query: 622  TAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARR 681
            T KK            A+ V  +  S  K+      KRQ       + K+  + E   R 
Sbjct: 628  TVKKS-----------AKKVKEEASSPLKS-----NKRQ-------REKVASDTEEADRT 664

Query: 682  KKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPAT 741
              KK     ++E + P    + E E+S           ++ +++  G+  P+        
Sbjct: 665  SSKKTK---TQEISRPNSPSEGEGESS-----------DSRSVNDEGSSDPKD-----ID 705

Query: 742  VNNSSDTESIPSPH-TEAAKDTGQNGP----KPPATLGADGPPPGPPTPPPEDIPAPTE- 795
             +N S + SIPSP   E+  D+         +PPA     G  P P + PP     PT  
Sbjct: 706  QDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG 765

Query: 796  PTPASEAT---GAPTPPPAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQKPPAAEE 850
            PTP++ A    G+PT   AP  P AP   VP    ++  A  P  P        P     
Sbjct: 766  PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPP 825

Query: 851  LAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAE---------KKEGGSG 901
            L   TG A +P          + P  G+      +   G L              +   G
Sbjct: 826  LQPLTGSAGQP----SAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQG 881

Query: 902  RATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPL 961
            +A    S  A     S    ++    +++   + + L P P  +     P     PQ P 
Sbjct: 882  QAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPA 941

Query: 962  DLKQLKQRAAAIP-PIVTKVHEPPREDAAP-----TKPAPPAPPPPQNLQPESDAPQQPG 1015
                      + P P     + PP     P     T   P A PPP  L P+S       
Sbjct: 942  PQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSP 1001

Query: 1016 SSPRGKSRS---PAPPAD-------KEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVP 1065
            + P G ++S   P PPA        + A +P F     A+   +PG PP  T   P   P
Sbjct: 1002 AQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPF-----AQHPFVPGGPPPIT---PPTCP 1053

Query: 1066 PREVIKASP--HAPDPSAFSYAPPGH-------PLPL------GLHDTARPVLPRPP--T 1108
                  A P   A  P + + A  G        PLP        L D   P  P PP  +
Sbjct: 1054 STSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRS 1113

Query: 1109 ISNPPPLISSAKHPSVLERQIGAISQG 1135
             S  P ++ +  H S   R    + +G
Sbjct: 1114 PSPEPTVVDTPSHASQSARFYKHLDRG 1140



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%)

Query: 1802 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1861
            ERER++++E++R+RERE+                   E    +  SS    G  S P   
Sbjct: 1181 EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 1223

Query: 1862 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1920
               H      P         P +  +T    + T  E + P V+  T+ + P   P    
Sbjct: 1224 GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 1281

Query: 1921 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1977
             P  A H P    L  V PT+ E  L  +E   R  R    R      F  KPP    L 
Sbjct: 1282 DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 1338

Query: 1978 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2034
            PA++P +         +PP +G             PH  AS  P   P           Q
Sbjct: 1339 PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 1385

Query: 2035 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2094
             +P       L +   H    +    +P++ +   ++T     P H +    SH+   L 
Sbjct: 1386 LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 1437

Query: 2095 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2152
              Q  P+  G      P + PL     ++ P L   P   G      L Q  H  E++  
Sbjct: 1438 LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 1492

Query: 2153 D-YTRHHPQQLSAPLPAPL 2170
              +   +P+ L   +P P+
Sbjct: 1493 PVFGTPYPRDLPGAIPPPM 1511



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%)

Query: 1405 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1463
            K +A  PLK  K   E + +  +EA R+  +  + +    P  P       EG  +    
Sbjct: 637  KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 692

Query: 1464 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1522
            +  D G+S       D RS       T P +  P D  +D+   + +  ++ L+++P   
Sbjct: 693  VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 741

Query: 1523 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1576
             +  G       AP   P+L  P  +P        G+P A   P   P     P P    
Sbjct: 742  QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 800

Query: 1577 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1610
             Q  +L   +                + LT +  + +   H+  P H             
Sbjct: 801  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 860

Query: 1611 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1660
                HP P  P+    +   G     +    A+  TS+       A  +   PR      
Sbjct: 861  PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 920

Query: 1661 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1705
                  H+ P PT P         H +PP+L    P +             ++S   HH 
Sbjct: 921  APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 979

Query: 1706 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1765
              +A      ++    P  SS      A P G   L+Q  +LP   PP    P T + ++
Sbjct: 980  PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 1028

Query: 1766 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1825
            A     PQP  ++H   P  PGGP  +T PT  S+S                        
Sbjct: 1029 A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 1056

Query: 1826 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1869
                  P   PGT      SG++  GG   G SS P             A    +    P
Sbjct: 1057 -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 1111

Query: 1870 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1929
             SP  +  +   PS  H +        ++    +  R+     P+              G
Sbjct: 1112 RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 1156

Query: 1930 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1974
              L       +E     +EA + AR ER R                +   A  A   A  
Sbjct: 1157 SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 1214

Query: 1975 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2019
            G      L          EP P     VPP  G  T A RT ++   PH  SP     P 
Sbjct: 1215 GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 1274

Query: 2020 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2060
              P + +DP                  RE  + + +   I+E ELR     G    P  +
Sbjct: 1275 YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 1334

Query: 2061 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2101
            +P+ P ++P        +LT       H        L  L++  L     +LRP+   P 
Sbjct: 1335 DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 1394

Query: 2102 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2159
            +L  E  H   +  L     +   +    P    H  + + L  H  + + Q      HP
Sbjct: 1395 RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 1454

Query: 2160 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2189
                L+A      + +P  + P   L +PP +
Sbjct: 1455 LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 1486



 Score = 39.7 bits (91), Expect = 0.038
 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%)

Query: 1969 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2028
            K  A+   E ASSP K S  R      S      RT +K       S      P S S+ 
Sbjct: 630  KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 683

Query: 2029 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2088
              E + S          RS+   GSS  P+ ++  +  +SPS+      P+  E    S 
Sbjct: 684  EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 728

Query: 2089 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2148
             + ++   QP  ++          + P P S P  +P L T         V         
Sbjct: 729  AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 779

Query: 2149 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2208
              T     + PQ  +AP+P           P L  +RPPS    P P    P +    S 
Sbjct: 780  --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833

Query: 2209 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2268
            G   +P   +  + G G  G   +     +  PG  +    P     G+    +   +  
Sbjct: 834  GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 893

Query: 2269 PGNTSQPPAFFSKL 2282
            P  + Q PA  S L
Sbjct: 894  PHTSLQLPASQSAL 907



 Score = 33.9 bits (76), Expect = 2.1
 Identities = 12/24 (50%), Positives = 19/24 (79%)

Query: 1796 TTTSSSERERDRDRERDRDREREK 1819
            T     ++++++DR+RDRDREREK
Sbjct: 2    TADKDKDKDKEKDRDRDRDREREK 25



 Score = 32.0 bits (71), Expect = 7.9
 Identities = 12/45 (26%), Positives = 28/45 (62%)

Query: 491  GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535
            G    +++++  ++ +++ +   R  +E + EKEKE+E E+E E+
Sbjct: 1156 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 1200


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 148/624 (23%), Positives = 213/624 (34%), Gaps = 100/624 (16%)

Query: 505  QQQQQQPMPRSSQEEKDEKE---KEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEK 561
            +++  +P+   S  E+DEKE   +E+E+ +EEE+ E E ++ED   + +DD    +ND++
Sbjct: 1020 RRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDE 1079

Query: 562  EAVASKG--RKTANSQGRRKGRITRSMANEANSEEAITPQQSAEL-ASMELNESSRWTEE 618
            +   S+   +   +S       I  S A   +S E+    +S+E  +S E + SS   EE
Sbjct: 1080 DTALSEASEKDEGDSDEEETVSIVTSKAEATSSSES---SESSEFESSSESSPSSSEDEE 1136

Query: 619  EMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERN 678
            E+                +AR                       +E  ++ + +M  E +
Sbjct: 1137 EV----------------VAR-----------------------EEEEEEEEEEMVAEES 1157

Query: 679  ARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSG 738
                  +      EEAA  P        A    G EEE+  E EA+          E   
Sbjct: 1158 MASAGPEDFEQDGEEAALAPGAP-----AVDSLGMEEEVDIETEAVAPEERPSMLDEPPL 1212

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 798
            P  V   +D+   P     + +      P+PPA      PP  P   P  D+    EP P
Sbjct: 1213 PVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEV--EPEP 1270

Query: 799  ASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA 858
                     PP  PP P  PP   P+ E  + +  + P E   E  PP    L     K+
Sbjct: 1271 PMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKS 1330

Query: 859  EEPVKSECTEEAE---EGPAKGKDAEAAEATAE----GALKAEKKEGGSGRATTAKSSGA 911
            +       T   E    G + G    + +         A       GG  R      S  
Sbjct: 1331 QSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFT 1390

Query: 912  PQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAA 971
            P  S+ S            G    R       +L  TG P     P  PL L        
Sbjct: 1391 PTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLP-LPLPL-------- 1441

Query: 972  AIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADK 1031
            A+P ++      P     P  PAP A  PP    P    P +P  SP        P    
Sbjct: 1442 ALPAVLRAQARAP-TPLPPLLPAPLASCPP----PMKRKPGRPRRSPPSMLSLDGP---- 1492

Query: 1032 EAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPL 1091
               +P    A   E   LPG P         PV P      S H P      +   G P 
Sbjct: 1493 -LVRPPAGAALGRELLLLPGQPQT-------PVFP------STHDPRTVTLDFRNAGIPA 1538

Query: 1092 PLGLHDTARPVLPRPPTISNPPPL 1115
            P        P+ P+PP    PPP+
Sbjct: 1539 P------PPPLPPQPPPPPPPPPV 1556



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 80/366 (21%), Positives = 131/366 (35%), Gaps = 60/366 (16%)

Query: 824  KEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAA 883
            ++E  EE   A   EE E+     +++        E+   SE +E+ E    + +     
Sbjct: 1044 EQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIV 1103

Query: 884  EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSS-ATCSADEVDEAEGGDKNRLLSPRP 942
             + AE    +E  E     +++  S  + +D +   A    +E +E E   +  + S  P
Sbjct: 1104 TSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGP 1163

Query: 943  SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQ 1002
                  G+  A A     +D   +++        V     P   D       PP P   +
Sbjct: 1164 EDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDE------PPLPVGVE 1217

Query: 1003 NLQPESDAPQQPGSSPRGKSR-SPAPPADKEAEKPVFFPAFAAEAQ-KLPGDPPCWTSGL 1060
                  + P++PG S  G    SP PPA +   +P   P  A E   ++  +PP     L
Sbjct: 1218 EPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMM---L 1274

Query: 1061 PFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPL--ISS 1118
            P P+ P                       PLP           PRPP   +PPP    + 
Sbjct: 1275 PLPLQP-----------------------PLPP----------PRPPRPPSPPPEPETTD 1301

Query: 1119 AKHPSVLERQI------------GAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPK 1166
            A HPSV    +            G++++  S +  VP +   + P+   + GL L     
Sbjct: 1302 ASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTET-VPATPGGEPPLSGGSSGLSLSSPQV 1360

Query: 1167 KLAPFS 1172
              +PFS
Sbjct: 1361 PGSPFS 1366



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 117/503 (23%), Positives = 158/503 (31%), Gaps = 119/503 (23%)

Query: 767  PKPPATLGADGPPPGPPTPPP-------------EDIPAPTEPTPASEATGA-------- 805
            P+  AT  A  PPP   TP P                P P E   A+ A GA        
Sbjct: 372  PQDSATF-AHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRR 430

Query: 806  -PTPPPAPPS-------PSAPPPVVPKEEKEEETAAAPPVEEGEE----------QKPPA 847
             P PPP PP+       P  PP   P +    E    P      E          +  PA
Sbjct: 431  APAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPA 490

Query: 848  AEELAVDT--GKAEEPVKSECTE-------------EAEEGPAKGKDAEAAEATAEGALK 892
              E   D+   + E  +K + T+             + E  P     ++ +     G   
Sbjct: 491  GPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNS 550

Query: 893  AEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPR 952
                 G +  ++   S+G  +D   +    +DE +E + G     L PRP       DP 
Sbjct: 551  QPGFRGPTPPSSRPSSTGL-EDISPTPLPDSDEDEELDLG-----LGPRPPPEPGPPDPA 604

Query: 953  ANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPR---------EDAAPTKPAPPAP-PPPQ 1002
               S    + L  +  R     P   K+ E  +         +D  P+ P   A  P P 
Sbjct: 605  GLLSQTAEVALDLVGDRT----PTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPM 660

Query: 1003 NLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPF 1062
             + P + A   P          P PP       P  FP        LP  PP       F
Sbjct: 661  VVTPGAAAVAAPSVL---APTLPLPP-------PPGFP-------PLPPPPPPPPPQPGF 703

Query: 1063 PVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPL------I 1116
            P+PP   +   P  P P+  +   P  PLP      A P +P PP +   PP       +
Sbjct: 704  PMPP--PLPPPPPPPPPAHPAVTVPPPPLP------APPGVPPPPILPPLPPFPPGLFPV 755

Query: 1117 SSAKHPSVLERQIGAISQGMSVQLHV-----------PYSEHAKAPVGPVTMGLPLPMDP 1165
                   VL  Q G +     +Q  V           PY     A     + GL     P
Sbjct: 756  MQVDMSHVLGGQWGGMPMSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLP 815

Query: 1166 KKLAPFSGVKQEQLSPRGQAGPP 1188
                PFS         RGQ  PP
Sbjct: 816  PYRGPFS--LSNSGPGRGQHWPP 836



 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 39/122 (31%), Positives = 44/122 (36%), Gaps = 9/122 (7%)

Query: 723 ALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKP----PATLGADGP 778
           AL   G+  P  E       ++  D E I      +A  T  + PKP    P       P
Sbjct: 614 ALDLVGDRTPTSEKMDEGQQSSGEDME-ISDDEMPSAPITSADCPKPMVVTPGAAAVAAP 672

Query: 779 ----PPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAA 834
               P  P  PPP   P P  P P     G P PPP PP P  PPP  P          A
Sbjct: 673 SVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPA 732

Query: 835 PP 836
           PP
Sbjct: 733 PP 734



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 119/527 (22%), Positives = 162/527 (30%), Gaps = 103/527 (19%)

Query: 1756 GTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTK--PTTTSSSERERDRDRERDR 1813
            GTP T        P    PFS   S S   P  P++L    P  T  + R   +  +   
Sbjct: 272  GTPLT--------PRLGTPFSQDSSYSSRQPT-PSYLFSQDPAVTFKARRHESKFTDAYN 322

Query: 1814 DREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPR 1873
             R     +  S      A         S    G+ GG GGSS  P             P+
Sbjct: 323  RRHEHHYVHNSPAVTAVAGATAAFRGSSDLPFGAVGGTGGSSGPPFK---------AQPQ 373

Query: 1874 TQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCP-----L 1928
                    P     T   G  +A  P                P A FPP    P      
Sbjct: 374  DSATFAHTPPPAQATPAPGFKSAFSPYQT-------------PVAHFPPPPEEPTATAAF 420

Query: 1929 GGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEP 1988
            G    G +     P  LP   P     E+P    G      PP  + +E    P+ G  P
Sbjct: 421  GARDSGEFRRAPAPPPLPPAEPLAK--EKPGTPPG----PPPPDTNSMELGGRPTFGWSP 474

Query: 1989 RPLVPPVSGHATIARTPAKNLAPHHASP--------DPPAPPASASDPHRE---KTQSKP 2037
             P   P  G  T+  +PA    PH +          +         +P  +   + +  P
Sbjct: 475  EPCDSP--GTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSP 532

Query: 2038 FSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGL-PKHLEELDKSH-LE---GE 2092
             S    +L  L   G++  P    P  P S PS T  + + P  L + D+   L+   G 
Sbjct: 533  ISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGP 592

Query: 2093 LRPKQPGPVKLGGEAAHLPHLR-PLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVIT 2151
              P +PGP    G  +    +   L   +  +S  +       G    ++  +  S  IT
Sbjct: 593  RPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPIT 652

Query: 2152 QDYTRHHPQQLSAPLPAPLYSFPGASC--------PVLDLRRPPSDLYLPPPDHGAPARG 2203
                       SA  P P+   PGA+         P L L  PP    LPPP    P   
Sbjct: 653  -----------SADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPP--- 698

Query: 2204 SPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYP 2250
                      P+P        G     P+ PP     P H    V P
Sbjct: 699  ----------PQP--------GFPMPPPLPPPPPPPPPAHPAVTVPP 727



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 34/126 (26%), Positives = 46/126 (36%), Gaps = 16/126 (12%)

Query: 703 EEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDT 762
           E+M+    S  E+  + + E   A    +   +C  P  V   +   + PS         
Sbjct: 626 EKMDEGQQSSGEDMEISDDEMPSAP---ITSADCPKPMVVTPGAAAVAAPSVLAPTL--- 679

Query: 763 GQNGPKPPATLGADGPPPGPPTPP------PEDIPAPTEPTPASEATGAPTPPPAPPSPS 816
               P PP       PPP PP PP      P  +P P  P P +       PPP P  P 
Sbjct: 680 ----PLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPG 735

Query: 817 APPPVV 822
            PPP +
Sbjct: 736 VPPPPI 741



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 26/75 (34%), Positives = 29/75 (38%), Gaps = 5/75 (6%)

Query: 778  PPPGPPTPPPEDIPAPTEPT--PASEATGAPTPPPAPPSPSAPPPVVPKE---EKEEETA 832
            PPP PP PPP   P P EPT  P  E          PP P     V  +     K     
Sbjct: 1540 PPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPW 1599

Query: 833  AAPPVEEGEEQKPPA 847
              PP +  E+  PPA
Sbjct: 1600 RRPPKKRHEDLVPPA 1614



 Score = 37.4 bits (85), Expect = 0.19
 Identities = 38/121 (31%), Positives = 47/121 (38%), Gaps = 28/121 (23%)

Query: 765  NGP--KPPA--TLGAD-----GPPPGPPTPPPED------------IPAPTEPTPASEAT 803
            +GP  +PPA   LG +     G P  P  P   D            IPAP  P P     
Sbjct: 1490 DGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQ--- 1546

Query: 804  GAPTPPPAPPSPSAPPPVVPKE-EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPV 862
              P PPP PP P  P  +  KE + +  + A PP   G ++      ELA   G    P 
Sbjct: 1547 --PPPPPPPP-PVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPP 1603

Query: 863  K 863
            K
Sbjct: 1604 K 1604



 Score = 37.0 bits (84), Expect = 0.25
 Identities = 105/444 (23%), Positives = 143/444 (32%), Gaps = 86/444 (19%)

Query: 1797 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSS 1856
            T  S   E+D   E D D E   SI+TS               +++ SS SS      SS
Sbjct: 1081 TALSEASEKD---EGDSDEEETVSIVTSKA-------------EATSSSESSESSEFESS 1124

Query: 1857 RPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMK----------GIITAVEPSTPTV-- 1904
              +S S +     +  R ++  ++   ++    M           G   A+ P  P V  
Sbjct: 1125 SESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDS 1184

Query: 1905 --------LRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPE 1956
                    + + + +   RP+    P     +    D   P   E   L +E   +  PE
Sbjct: 1185 LGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPP--EEPGLSQEGAMLLSPE 1242

Query: 1957 RPRADTGHAFLAKPPARSGLEPASSPSKGSE----------------------PRPLVPP 1994
             P  +      A+PP    L P  +P    E                      PRP  PP
Sbjct: 1243 PPAKEVE----ARPP----LSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPP 1294

Query: 1995 VSGHATIA---RTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYH 2051
                 T A     P + LA  H    P    + A     E   + P     L   S G  
Sbjct: 1295 PEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLS 1354

Query: 2052 GSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLP 2111
             SS    G     P  SPSL+   GLP+     D S       P   GP+ L      LP
Sbjct: 1355 LSSPQVPGSPFSYPAPSPSLS-SGGLPR-TPGRDFSFTPTFSEPS--GPLLL--PVCPLP 1408

Query: 2112 HLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLP-APL 2170
              R    S P +SP+L            + L   +  V+          Q  AP P  PL
Sbjct: 1409 TGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLR--------AQARAPTPLPPL 1460

Query: 2171 YSFPGASCPVLDLRRPPSDLYLPP 2194
               P ASCP    R+P      PP
Sbjct: 1461 LPAPLASCPPPMKRKPGRPRRSPP 1484



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 66/312 (21%), Positives = 98/312 (31%), Gaps = 33/312 (10%)

Query: 1735 PRGIIDLSQVPHLPVLVPPTPGTPATAMDRL--AYLPTAPQPFSSRHSSSPLSPGGPTHL 1792
            P  ++ L   P LP   PP P +P    +    ++    P+P +  H   P +PG    L
Sbjct: 1270 PPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHP--PHTPGLCGSL 1327

Query: 1793 TKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSG--SSGG 1850
             K  +T +       +            +  S+  V  +P   P    S  S G   + G
Sbjct: 1328 AKSQSTETVPATPGGEPPLSGG---SSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPG 1384

Query: 1851 GGGSSSRPASHSHAHQHSPISPRTQDALQQRPS-----VLHNTGMKGIITAVEP---STP 1902
               S +   S        P+ P       +R       VL  TG+   +    P   + P
Sbjct: 1385 RDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALP 1444

Query: 1903 TVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADT 1962
             VLR+ + +    P     P   CP         P    P +L  + P            
Sbjct: 1445 AVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGP------------ 1492

Query: 1963 GHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPP 2022
                L +PPA + L        G    P+ P      T+         P    P PP PP
Sbjct: 1493 ----LVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPP 1548

Query: 2023 ASASDPHREKTQ 2034
                 P  E T+
Sbjct: 1549 PPPPPPPVEPTK 1560



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 36/124 (29%), Positives = 52/124 (41%), Gaps = 13/124 (10%)

Query: 95   LGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPP 154
            LG  E   IE++    E  P  L  P   +   +PA S +  ++  L+ +   +  P PP
Sbjct: 1185 LGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPP 1244

Query: 155  HTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPV 214
                E+E  PP LS E   ++   V+ E  M+      L    Q        PP P +P 
Sbjct: 1245 AK--EVEARPP-LSPERAPEHDLEVEPEPPMM------LPLPLQP----PLPPPRPPRPP 1291

Query: 215  SPPP 218
            SPPP
Sbjct: 1292 SPPP 1295


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 88.2 bits (217), Expect = 9e-17
 Identities = 125/490 (25%), Positives = 163/490 (33%), Gaps = 93/490 (18%)

Query: 779  PPGPPTPPPEDIPAPTEPTPASEAT-------------GAPTPPPAP---PSPSAPPPVV 822
            PPG P PPP   PA      A+ A              GA  P  AP   P+ ++ PP  
Sbjct: 29   PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPAS 88

Query: 823  PKEEK---EEETAAAP------------PVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 867
             + E+    + T+  P            P   G++    +AEE  V  GKA E  K    
Sbjct: 89   GRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE-TVARGKATEAPKRSAL 147

Query: 868  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 927
                     G              +A   E G  R   +     P +    +  SA E  
Sbjct: 148  SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 207

Query: 928  EAE-----------GGDKNR------------LLSPRPSLLTPTGDPRANASPQKPLDLK 964
              E           GG   R            L SP  S  +  G PRA A P +P    
Sbjct: 208  TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP---- 263

Query: 965  QLKQRAAAIPPIVTKVHEPPREDAAP----------TKPAPPAPPPPQNLQPESDAPQQP 1014
            + K   A  PP VT    PPR+DAAP            P+P APP P         P  P
Sbjct: 264  KPKGLQALRPPQVT----PPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPP 319

Query: 1015 GSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASP 1074
             + P   + S   P  +     +  P  +  A   P  PP         +PP +   + P
Sbjct: 320  ATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA------LALPPLQAPPSPP 373

Query: 1075 HAPDPSAFSYAPPGHPLPLGLHDTARPVLPRP-PTISNP------PPLISSAKHPSVLER 1127
             +P  S  +   P  P  L +H    P  P P P +  P      PP+  SA  PS    
Sbjct: 374  ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433

Query: 1128 QIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGP 1187
             + A        L VP S  A  P+ P     P    P    P    K    +P   A P
Sbjct: 434  SLAA------PPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 487

Query: 1188 P-ESLGVPTA 1196
            P ++L  P A
Sbjct: 488  PLQALPSPPA 497



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 119/506 (23%), Positives = 180/506 (35%), Gaps = 92/506 (18%)

Query: 751  IPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAP--TEPTPASEATGAPT- 807
            +  P  +AA   G     P AT     PP     P  + +P+P  T P+ A+ + G+PT 
Sbjct: 276  VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL 335

Query: 808  ---------PPPAP---PSPSAPPPV-VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVD 854
                     PP +P   P P APP + +P  +      A+PP+       P A   LAV 
Sbjct: 336  QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395

Query: 855  TGKA------EEPVKSECTEEAEE--GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTA 906
              +A        PV++  +  A     P+    ++A  + A   L+       S  A+  
Sbjct: 396  LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP----SPPASPP 451

Query: 907  KSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL--K 964
             S  A     +    +A  +         +L  P P        P   A P  P     +
Sbjct: 452  MSPSATPPPQAPPPLAAPPL---------QLAKPPPQAPPALATPPLQALPSPPASFPGQ 502

Query: 965  QLKQRAAAIP--PIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1022
                 +A++P  P+ T   + P   AAP    PP+PP    LQ    AP++P        
Sbjct: 503  APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ----APRRP-------- 550

Query: 1023 RSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAF 1082
              P P  D     P    A A      PG PP          PP     ++   PD +  
Sbjct: 551  --PTPGPDTSVSGPRLTLALA------PGPPP----------PPSRSPSSTLSGPDLAGH 592

Query: 1083 SYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLIS-SAKHPSVLERQIGAISQGMSVQLH 1141
            S +    P  L  +D+     P     ++PPP    +A HP+       A S+G +  L 
Sbjct: 593  SSSATSTPEELRGYDSG----PEGGAAASPPPDAELAACHPA-------AWSRGPAPPLA 641

Query: 1142 VPYSEHAKAPVGPVT-----MGLPLPMD---PKKLAPFSGVKQEQLSPRGQAGPPESLGV 1193
               +  A  P  P T      GL    +   P+   P  G      SP G +G   + G 
Sbjct: 642  FRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP-GTSGGKAAAGA 700

Query: 1194 PTAQEASVLRGTALGSVPGGSITKGI 1219
                 +   +   LG +P G++   +
Sbjct: 701  GAGASSRSPKQARLGELPLGALQASV 726



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 136/566 (24%), Positives = 188/566 (33%), Gaps = 135/566 (23%)

Query: 1753 PTPGTPATAMDRLAYLPTA----PQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRD 1808
            PTPGTP+ AM R +         P+P  S        P  PT   + + +S+SE      
Sbjct: 158  PTPGTPSPAMARRSRAAGTEVGLPRPAPSAR------PRPPTEGPRKSVSSASEHSTTEP 211

Query: 1809 RERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSG--SSGGGGGSSSRPASHSHAHQ 1866
                R R      L            RP +   S S+   SS    G S+R    + AH 
Sbjct: 212  SPAARRRPSAGGGLQ-----------RPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 260

Query: 1867 HSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT------- 1919
              P  P+   AL+  P V      K    A+ P + + L + S S+P  P+A        
Sbjct: 261  SQP-KPKGLQALRP-PQV--TPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLP 316

Query: 1920 FPPATH-----CPLGG-TLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLA--KPP 1971
             PPAT        LG  TL   +  L  P L P   P    P+ P A       A   PP
Sbjct: 317  SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP---PQAPPALALPPLQAPPSPP 373

Query: 1972 ARSGLEPASSPSKGSE--------------------PRPLVPPVSGHATIARTPAKNLAP 2011
            A   L P ++PS  +                       P  PP S   + + TP     P
Sbjct: 374  ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433

Query: 2012 HHASPDPPAPPASASDPHREKTQSKPFS---------------------------IQELE 2044
              A+P    PP+  + P    + + P                             +Q L 
Sbjct: 434  SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493

Query: 2045 LRSLGYHGSS-YSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKS-----HLEGELRPKQP 2098
                 + G + +SP    P+SP+++P       L   L ++  S      L+   RP  P
Sbjct: 494  SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP 553

Query: 2099 GP-VKLGGEAAHLPHLRPLPESQPSSSP-LLQTAPGVKGHQRVVTLAQH----------- 2145
            GP   + G    L  L P P   PS SP    + P + GH    T               
Sbjct: 554  GPDTSVSGPRLTLA-LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 612

Query: 2146 ---ISEVITQDYTRHHPQQLS--------------APLPAPLYSFPGAS---CPVLDLRR 2185
                S     +    HP   S              APLP P  + PG++   C + +   
Sbjct: 613  GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 672

Query: 2186 PPSDLYLPPPDHGAPARGSPHSEGGK 2211
            P S    P      P   SP + GGK
Sbjct: 673  PESATPAPGALDPGP---SPGTSGGK 695



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 118/465 (25%), Positives = 158/465 (33%), Gaps = 117/465 (25%)

Query: 681  RKKKKAPAAASE------EAAFPPVVEDEEMEASGVSG--NEEEMVEEAEALHASGNEVP 732
            R   +APA  S+      +A  PP V     +A+   G  +   +   + +   S +  P
Sbjct: 251  RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310

Query: 733  RGEC--SGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT---PPP 787
              +   S PAT  + + T S+ SP  +A   T    P PP +  A  PP  PP    PP 
Sbjct: 311  SLQTLPSPPATPPSQATT-SLGSPTLQA---THSFLPSPPLSPLATPPPQAPPALALPPL 366

Query: 788  EDIPAPTEPTPASE-ATGAP---------------TPPPAPP-----SPSAPPPVVPKEE 826
            +  P+P    P S  AT +P               +PPP+PP     SP A PPV P   
Sbjct: 367  QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP--- 423

Query: 827  KEEETAAAPPVEEGEEQKPP--AAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAE 884
                 +A PP      Q PP  AA  L V       P  S         P+     +A  
Sbjct: 424  -----SATPP-----SQAPPSLAAPPLQVPPSPPASPPMS---------PSATPPPQAPP 464

Query: 885  ATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSL 944
              A   L+  K                PQ   + AT     +             P P  
Sbjct: 465  PLAAPPLQLAKP--------------PPQAPPALATPPLQAL-------------PSPPA 497

Query: 945  LTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTK--VHEPPREDAAPTKPAPPAPPPPQ 1002
              P    +A  SP   L +  L       PP++    +  PP   A+PT  AP  PP P 
Sbjct: 498  SFP---GQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP- 553

Query: 1003 NLQPESDAPQQPGSSPR---GKSRSPAPPADKEAEKPVFFPAFA---AEAQKLPGDPPCW 1056
                    P    S PR     +  P PP  +     +  P  A   + A   P +   +
Sbjct: 554  -------GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 606

Query: 1057 TSG-----LPFPVPPREVIKASPHA----PDPSAFSYAPPGHPLP 1092
             SG        P P  E+    P A    P P       PG PLP
Sbjct: 607  DSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLP 651



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 169/713 (23%), Positives = 232/713 (32%), Gaps = 166/713 (23%)

Query: 1826 TTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVL 1885
            T  E AP  R G  ++S    S   G G  + PA ++      P+S   + +   RP  L
Sbjct: 69   TIPESAP--RAGPTRTSRPPAS---GRGERAPPAKNTSP---GPVSSPGRASGTTRPGPL 120

Query: 1886 HNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLL 1945
               G KG+  + E    TV R  +T +P R A +         G   D   PT   P   
Sbjct: 121  ---GQKGLRISAEE---TVARGKATEAPKRSALS--------AGARRDTSGPTPGTP--- 163

Query: 1946 PKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTP 2005
               +P +AR  R RA      L +P   +   P   P++G  PR  V   S H+T   +P
Sbjct: 164  ---SPAMAR--RSRAAGTEVGLPRPAPSARPRP---PTEG--PRKSVSSASEHSTTEPSP 213

Query: 2006 AKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSP 2065
            A    P             ++    ++  S+  S     L S    G S       P  P
Sbjct: 214  AARRRP-------------SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 260

Query: 2066 VSSPSLTHDKGLPKHLEELDKSHLEGELRPKQP--GPVKLGGEAAHLPHLRPLPESQPSS 2123
             S P        PK L+ L    +    +   P  GP+     A   P   P P S P S
Sbjct: 261  -SQPK-------PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSP-SAPPS 311

Query: 2124 SPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL-- 2181
               L + P     Q   +L     +  T  +       L +P  +PL + P  + P L  
Sbjct: 312  LQTLPSPPATPPSQATTSLGSPTLQA-THSF-------LPSPPLSPLATPPPQAPPALAL 363

Query: 2182 -DLRRPPSDLYLPP------PDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSP 2234
              L+ PPS    PP      P   AP   + H      SP P+             P SP
Sbjct: 364  PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA--------PFSP 415

Query: 2235 PEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKK 2294
            P     P  S SA  P               S++P + + PP        ++  M  S  
Sbjct: 416  P---ASPPVSPSATPP---------------SQAPPSLAAPPLQVPPSPPASPPMSPSA- 456

Query: 2295 QEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIR 2354
                    T     P   ++ P  ++   P      L T   QA+               
Sbjct: 457  --------TPPPQAPP-PLAAPPLQLAKPPPQAPPALATPPLQALP-------------- 493

Query: 2355 KALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHTLTSPGGGGKAKVSG 2414
                        SPP S     P + SASLP + P+     ++   L +P          
Sbjct: 494  ------------SPPASFPGQAPFSPSASLPMS-PLATPPPQAPPVLAAPLLQVPPSPPA 540

Query: 2415 RP---SSRKAKSPAP-----------GLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDR 2460
             P   + R+  +P P            LA G  PP   S  S         L+       
Sbjct: 541  SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS--------TLSGPDLAGH 592

Query: 2461 PSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLL 2513
             SSA STP          + G  ASPPP    A   P      AW   P P L
Sbjct: 593  SSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPA-----AWSRGPAPPL 640



 Score = 39.7 bits (91), Expect = 0.038
 Identities = 76/338 (22%), Positives = 112/338 (33%), Gaps = 59/338 (17%)

Query: 2174 PGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVS 2233
            P A  P L   RPP     PPP   A  R    +    R P   +   +GG        +
Sbjct: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG-------AT 69

Query: 2234 PPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSP-------GNTSQPPAFFSK--LTE 2284
             PE     G +R++  P   R GE+  P++  S  P         T++P     K     
Sbjct: 70   IPESAPRAGPTRTSRPPASGR-GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128

Query: 2285 SNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHAS 2344
            +   + + K  E  K+         + +   PGT     PA      M  RS+A    A 
Sbjct: 129  AEETVARGKATEAPKRSALSAGARRDTSGPTPGTP---SPA------MARRSRA----AG 175

Query: 2345 TNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHTLTSP 2404
            T +GL                   P  A +  P       P   P  +    S+H+ T P
Sbjct: 176  TEVGL-------------------PRPAPSARP-----RPPTEGPRKSVSSASEHSTTEP 211

Query: 2405 GGGGKAKVSG-----RPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED 2459
                + + S      RP+SR   S A  L+S  R    +        +   P    +   
Sbjct: 212  SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 271

Query: 2460 RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGP 2497
            RP           P +  L +  +A+P P   P+ S P
Sbjct: 272  RPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAP 309


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 115/596 (19%), Positives = 243/596 (40%), Gaps = 79/596 (13%)

Query: 170 EELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQI 229
           EEL +  D +  E+        +LKKK  +L+E+              P+    +S +Q+
Sbjct: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKL-------------PLAESEKSEIQL 246

Query: 230 IYDENRKKAEAAHRILEGLGPQVEL-----PLYNQPSDTRQYHENIKINQAMRKKLILYF 284
              E ++K E A  +L    PQV+       ++ Q  + R+  + I              
Sbjct: 247 NVKELKRKLERAKFLL----PQVQTNTLQEEMWRQEEELREQEKKI-------------- 288

Query: 285 KRRNHARKQWEQKFCQRYDQ-LMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQ 343
             R    K W Q+   R  +  M   E+K+ R E   R + KE + +E   ++  E+R+Q
Sbjct: 289 --RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQ 346

Query: 344 RELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDAD 403
            E  +  + ++ ++   +     +   +   + +   +    E++MR        +++ D
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ---EERMWEQD 403

Query: 404 QQ-RIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKT 462
           ++ R K   M        +V K R+   M  +++K   +E+ MQ  +        +  + 
Sbjct: 404 ERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE 463

Query: 463 VAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDE 522
                    + K+ EN      + ++++   +Q+++  +Q++ Q+Q++ +    ++ +D+
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523

Query: 523 KE----------KEKEAEKEEEKPEVEN----------DKEDLLKEKTDDTSGEDNDEKE 562
           +E          +EK  E+E++  E E           D+E+ +++KT +   +  D++E
Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583

Query: 563 AVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEE--M 620
            +  + R     +  +K R    M  E   EE +  Q+      M+  E   W +EE   
Sbjct: 584 KMREEERM---REREKKMREEEEMMRE--QEEKMQEQEE----KMQEQEEKMWEQEEKMQ 634

Query: 621 ETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKL-----KMEK 675
           E  +K   +  + W    +M   + + + K   + ++K Q  +++ +Q +      KMEK
Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694

Query: 676 ERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEV 731
           +   + KK        EE +     +    E   +   EE+M E+ E +     E+
Sbjct: 695 KTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEM 750



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 103/543 (18%), Positives = 229/543 (42%), Gaps = 45/543 (8%)

Query: 166 RLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRS 225
           R  +E++ +  +R+  +   + +Q  K+ +++++L E+  +  E EK +       +   
Sbjct: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEE 348

Query: 226 LVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMR----KKLI 281
            +Q   ++  ++ E      E +  Q E  L+ Q    R+  + ++  +       ++L 
Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEER-LWEQEKQMREQEQKMRDQEERMWEQDERLR 407

Query: 282 LYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIR 341
              +R     K WEQ    R ++ M+  EKK    E    +  +E ++RE  +K   E  
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEE---KMQEEERIREREKKMREEEE 464

Query: 342 KQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYD 401
             RE +E+MQ +  +            +  + E  + L EQE +++Q  ++         
Sbjct: 465 TMREQEEKMQKQ--EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW-------- 514

Query: 402 ADQQRIKFINMNGLMADPMKVYKDRQVMN----MWSEQEKETFREKFMQHPKNFGLIASF 457
             +Q  K  +   +     K+++  ++      MW ++EK   +E+ M   +        
Sbjct: 515 --EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER------ 566

Query: 458 LERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQ---QQQQQQQQQQQQQQQQPMPR 514
           +E+KT  +    +   +K    + +  R  + R + +   +Q+++ Q+Q+++ Q+Q    
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626

Query: 515 SSQEEKDEKEKEKEAEKEE----------EKPEVENDKEDLLK-EKTDDTSGEDNDEKEA 563
             QEEK ++++EK  E+EE          E+  +   KE L + EK  +       E++ 
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686

Query: 564 VASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETA 623
              +  +    +  +K      M  E +  E     +  E    E  E  +  EE+M+  
Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746

Query: 624 KKGLLE-HGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRK 682
           ++ + E   + W    +M   + + + K   + ++K Q  ++I +Q +   ++E   R +
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806

Query: 683 KKK 685
           ++K
Sbjct: 807 EEK 809



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 94/480 (19%), Positives = 198/480 (41%), Gaps = 46/480 (9%)

Query: 169 KEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQ 228
           +E++ + ++++  E  M EQ+     ++++  EEE  +  E +       +  +   + +
Sbjct: 416 QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475

Query: 229 IIYDENRKKAEAAHRILEGLGPQVEL-----PLYNQPSDTRQYHENIKINQAM---RKKL 280
              +EN  + E      + L  Q E       +  Q     +  E I+  + M    KK+
Sbjct: 476 --QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533

Query: 281 ILYFKRRNHARKQWEQKFCQRYDQLMEAW-------------EKKV----ERIENNPRRR 323
               K R    + WEQ+   R DQ  + W             EKK     E++    R R
Sbjct: 534 WRQEKMREQEDQMWEQEEKMR-DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMR 592

Query: 324 AKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQE 383
            +E K+RE  E    +  K +E +E+MQ +  +            E ++ E  + + EQE
Sbjct: 593 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQE 651

Query: 384 NLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREK 443
               + ++L      L++ ++ +        +     K+++  ++     EQEK+T+ ++
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQ----EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE 707

Query: 444 FMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQ 503
            M+  ++        E+K   E  +     +K +  +  ++       + +++  +Q+++
Sbjct: 708 KMREEESM----REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEK 763

Query: 504 QQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGED---NDE 560
             +QQ+ P     +E+  E EK +E EK  E+ E   D+E+ ++ + +   G++     +
Sbjct: 764 MWEQQRLP---EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820

Query: 561 KEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEM 620
           +E +  +  K    + +  G+  +    E   EE +   Q  E    E  E  R  EE+M
Sbjct: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKM---QGQEEKMREQEEKMRGQEEKM 877



 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 84/448 (18%), Positives = 188/448 (41%), Gaps = 64/448 (14%)

Query: 166 RLSKEELIQNMDRVDREI--TMVEQQISKLKKKQQQLEEEAAK-------PPEPEKPVSP 216
           ++ +EE I+  ++  RE   TM EQ+  K++K+++ + E+  K       P + EK    
Sbjct: 445 KMQEEERIREREKKMREEEETMREQE-EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503

Query: 217 PPIESKHRSL---VQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKIN 273
             ++ +   +    + I D+     +      +    + E  ++ Q    R   + +   
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563

Query: 274 QAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAK-----ESK 328
           +   +K     K +   +K W+Q+   R ++ M   EKK+   E   R + +     E K
Sbjct: 564 EERMEK-----KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK 618

Query: 329 VREYYEKQFPEIRKQRELQERM----------------QSRVGQRGSGLSMSAARSEHE- 371
           ++E  EK + +  K +E +E+M                Q R+ ++   L       E E 
Sbjct: 619 MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678

Query: 372 VSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMN- 430
           + E  + + EQE +EK+ ++        +D ++ R +      +     K+ ++ ++M  
Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQE---KKTWDQEKMREE----ESMREREKKMREEEEMMRE 731

Query: 431 ----MWSEQEK--ETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVR 484
               M  ++EK  E   E + Q  K +       E++ + E     +  +K +  + +  
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791

Query: 485 RSYRRRGKSQQQQQQQQQQQQQQQQ----------QPMPRSSQEEKDEKEKEKEAEKEEE 534
           +  + R + ++ + Q+++ + Q+++          Q      QEEK   ++EK   +EE+
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851

Query: 535 KPEVENDKEDLLKEKTDDTSGEDNDEKE 562
             E    +E+ ++E+ +   G++   +E
Sbjct: 852 MEEKMQGQEEKMREQEEKMRGQEEKMRE 879



 Score = 55.1 bits (131), Expect = 9e-07
 Identities = 69/368 (18%), Positives = 162/368 (44%), Gaps = 60/368 (16%)

Query: 169 KEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQ 228
           +EE ++  +R+      + ++   +++++++++E+  K  E E+ +     E K +   +
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ--EEKMQEQEE 638

Query: 229 IIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRN 288
            ++++  K  E   ++ E    Q  LP   +  +    HE ++  + M+++         
Sbjct: 639 KMWEQEEKMWEQEEKMWE----QQRLP---EQKEKLWEHEKMQEQEKMQEQ--------- 682

Query: 289 HARKQWEQKFCQRYDQLME--AWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQREL 346
              K WEQ+  ++  Q  E   W+++  R E + R R  E K+RE  E    +  K +E 
Sbjct: 683 -EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQ 739

Query: 347 QERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQR 406
           +E+MQ +               E E+ E  + + EQE    + ++L      L++ ++  
Sbjct: 740 EEKMQEQ---------------EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK-- 782

Query: 407 IKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAEC 466
                    M +  K+++  + M    ++EK   +E+ M+  +         E+    E 
Sbjct: 783 ---------MQEQEKIWEQEEKMR--DQEEKMRGQEEKMRGQE---------EKMRGQEE 822

Query: 467 VLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKE 526
            ++    K     + +  +  +  G+ ++ +++ Q Q+++ ++Q      QEEK  +++E
Sbjct: 823 KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882

Query: 527 KEAEKEEE 534
           K   +EE+
Sbjct: 883 KMRGQEEK 890



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 82/433 (18%), Positives = 173/433 (39%), Gaps = 42/433 (9%)

Query: 307 EAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAA 366
           E  +K  E  E  P   +++S+++   ++   ++ + + L  ++Q+        L     
Sbjct: 222 ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNT------LQEEMW 275

Query: 367 RSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDR 426
           R E E+ E    + +QE  EK  RQ   +        +Q  K       + +  K  +  
Sbjct: 276 RQEEELREQEKKIRKQE--EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR-- 331

Query: 427 QVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRS 486
                  EQEKE   +K ++  +         E+    E  ++    K  E  + + R+ 
Sbjct: 332 -------EQEKELREQKELREQE---------EQMQEQEEKMWEQEEKMREQEEKMWRQE 375

Query: 487 YR--RRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKED 544
            R   + K  ++Q+Q+ + Q+++  +   R  ++E+  +E+EK  E+ E+  E +  +E 
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE- 434

Query: 545 LLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAEL 604
             +EK      E   E+E +  + +K    +   + +  +    E N  E    Q+  E 
Sbjct: 435 --QEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE----QEEKEW 488

Query: 605 ASMELNESSR--WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNL 662
               L E     W +E+M+  ++ + E          M G     Q K  +   K R+  
Sbjct: 489 QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG-----QEKKMWRQEKMREQE 543

Query: 663 DEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAE 722
           D++ +Q +   ++E+    ++++      E+       E++  E   +   E++M EE E
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603

Query: 723 ALHASGNEVPRGE 735
            +     ++   E
Sbjct: 604 MMREQEEKMQEQE 616


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 286/1277 (22%), Positives = 452/1277 (35%), Gaps = 220/1277 (17%)

Query: 59   IQPQRRRPSLLSEFQPGNERSQEL---HLRPESHSYLP----ELGKSEMEFIESKRPRLE 111
            + P+  +   LSE  P  E S ++    L PES   L      LGK EM  +        
Sbjct: 1189 VSPEDTQSLSLSEESPSKETSLDVSSKQLSPESLGTLQFGELNLGKEEMGHLMQAEDTSH 1248

Query: 112  LLPDPLLRPSPLLATGQP--------AGSEDLTKDRSLTGKLEPVSPPSP-PHTDPELEL 162
                P+  P P  AT  P        +   D+T D      L+  SP S   H+ P    
Sbjct: 1249 HTA-PMSVPEPHAATASPPTDGTTRYSAQTDITDD-----SLDRKSPASSFSHSTPS--- 1299

Query: 163  VPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESK 222
                        N   +   IT  ++ I          +   +K PE     +   I  K
Sbjct: 1300 -----------GNGKYLPGAITSPDEHILTP-------DSSFSKSPESLPGPALEDIAIK 1341

Query: 223  HRSLVQIIYD---ENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKK 279
                V  + D   E +K+ E    +L+     +E     +P DT  Y ++    +A+  K
Sbjct: 1342 WEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKD----EALHVK 1397

Query: 280  LILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPE 339
                    N A KQ ++   Q+   L    E+K   +E   + +A E K ++  EK    
Sbjct: 1398 --------NEAVKQQDKALEQKGRDL----EQKDTALEQ--KDKALEPKDKDLEEKD-KA 1442

Query: 340  IRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPML 399
            + ++ ++ E     + Q+ + L       E +  ++       E  ++ + Q   IP   
Sbjct: 1443 LEQKDKIPEEKDKALEQKDTALEQKDKALEPKDKDL-------EQKDRVLEQKEKIPEEK 1495

Query: 400  YDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLE 459
              A  Q+++ +       D +   KDR +     + +K   ++   Q  K+        E
Sbjct: 1496 DKALDQKVRSVEHKA-PEDTVAEMKDRDL----EQTDKAPEQKHQAQEQKD-----KVSE 1545

Query: 460  RKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEE 519
            +K  A    Y+ L +K+E                +Q  Q  ++  Q Q+Q+ +    QE+
Sbjct: 1546 KKDQALEQKYWALGQKDEAL--------------EQNIQALEENHQTQEQESLV---QED 1588

Query: 520  KDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRK 579
            K  K K  E EK  EK +   +K + L EKT     E     E++  +GR     +   +
Sbjct: 1589 KTRKPKMLE-EKSPEKVKAMEEKLEALLEKTKALGLE-----ESLVQEGRAREQEEKYWR 1642

Query: 580  GRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIA- 638
            G+       E +        +  ELA    + S           +   LE    W  ++ 
Sbjct: 1643 GQDVVQEWQETSPTREEPAGEQKELAPAWEDTSPEQDNRYWRGREDVALEQDTYWRELSC 1702

Query: 639  -RMVG---SKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAAS--- 691
             R V           +  Y   ++   LDE         E+E   R    ++P A+    
Sbjct: 1703 ERKVWFPHELDGQGARPHYTEERESTFLDEGPDD-----EQEVPLREHATRSPWASDFKD 1757

Query: 692  -EEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNN---SSD 747
             +E++    +E E   A    G   E   E + L  S  E+     S P  V     S+ 
Sbjct: 1758 FQESSPQKGLEVERWLAESPVGLPPE---EEDKLTRSPFEIISPPASPPEMVGQRVPSAP 1814

Query: 748  TESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPT 807
             +  P P  +      +N P  P+ L AD PP       P+D P P  P P S A G PT
Sbjct: 1815 GQESPIPDPKLMPHM-KNEPTTPSWL-ADIPPW-----VPKDRPLP--PAPLSPAPGPPT 1865

Query: 808  PPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 867
            P P     S  P        E ++  A   E   E +      L  D  KAE        
Sbjct: 1866 PAP----ESHTPAPFSWGTAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAE-------G 1914

Query: 868  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 927
            E  EEG         AEA  + +  ++  E     ATT      P+  + +         
Sbjct: 1915 EREEEG--------RAEAPDKSSHSSKVPEASKSHATTEPEQTEPEQREPTPYPDERSFQ 1966

Query: 928  EAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP--LDLKQL---------KQRAAAIPPI 976
             A+  ++  L    P+   PT +P   A+   P  L  K+          K+ ++ I P 
Sbjct: 1967 YADIYEQMMLTGLGPA--CPTREPPLGAAGDWPPCLSTKEAAAGRNTSAEKELSSPISPK 2024

Query: 977  VTKVHEPPREDAAPTKP-APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEK 1035
              +   P    AA   P  PP P P  +++P    P  P  +P   S+ P+PP +     
Sbjct: 2025 SLQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLTPPAVPPRAPI-LSKGPSPPLNGNI-- 2081

Query: 1036 PVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGL 1095
                    +  ++ P       S         E+ K +   P+  A S +PP HP+P+G 
Sbjct: 2082 -----LSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKEAQSPSPP-HPIPMG- 2134

Query: 1096 HDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPV 1155
                 P L  P T ++  P + S   P+                L  P S    + + P 
Sbjct: 2135 ----SPTL-WPETEAHVSPPLDSHLGPA-------------RPSLDFPASAFGFSSLQPA 2176

Query: 1156 TMGLPLPMDPKKLAP-----FSGVKQEQLSPRGQAGPP------ESLGVPTAQEA-SVLR 1203
               LP P +P+  AP     FSG +   L+P    GPP      E L V  A    S L 
Sbjct: 2177 PPQLPSPAEPRS-APCGSLAFSGDRALALAP----GPPTRTRHDEYLEVTKAPSLDSSLP 2231

Query: 1204 GTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTP--ADVLYKGTITRIIGEDSPSR 1261
                 S PG  +   +P    P+  A++   S    TP  + V  + + +    E     
Sbjct: 2232 QLPSPSSPGAPLLSNLPR---PASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGE 2288

Query: 1262 LDRGREDSLPKGHVIYE 1278
            LD G E   P  H +++
Sbjct: 2289 LDPGME---PAAHSLWD 2302



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 143/663 (21%), Positives = 210/663 (31%), Gaps = 118/663 (17%)

Query: 746  SDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGA 805
            S  E+    +T A K+   + P  P +L +D P           +P   EP P+ E +  
Sbjct: 2001 STKEAAAGRNTSAEKEL--SSPISPKSLQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLT 2058

Query: 806  P--TPPPAPPSPSAPPPVVPKE--EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP 861
            P   PP AP     P P +         +  +  P E G      +  +  ++ G  E+P
Sbjct: 2059 PPAVPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQP 2118

Query: 862  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEG---------GSGRATTAKSSGAP 912
             K   +         G      E  A  +   +   G          S    ++     P
Sbjct: 2119 EKEAQSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPSLDFPASAFGFSSLQPAPP 2178

Query: 913  QDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP-RANASPQKPLDLKQLKQRAA 971
            Q    +   SA     A  GD+   L+P P   T   +      +P     L QL   ++
Sbjct: 2179 QLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSS 2238

Query: 972  AIPPIVTKVHEPPR----EDAAPTKPAPPAPPPPQNLQPESDAPQQ------PGSSPRGK 1021
               P+++ +  P      E ++     P      +   P  +A +Q      PG  P   
Sbjct: 2239 PGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGELDPGMEPAAH 2298

Query: 1022 SR------SPAPPADKEAEKPVFFPAFAAEAQKLPGDP-----PCWTS--------GLPF 1062
            S       SPAPPA  +           A A  LPGD      PC             PF
Sbjct: 2299 SLWDLTPLSPAPPASLDLA--------LAPAPSLPGDMGDGILPCHLECSEAATEKPSPF 2350

Query: 1063 PVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLP---------------RPP 1107
             VP  +     P    P+     PPG P P    +      P               RP 
Sbjct: 2351 QVPSEDCAANGPTETSPN-----PPG-PAPAKAENEEAAACPAWERGAWPEGAERSSRPD 2404

Query: 1108 TISNPP----PLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPM 1163
            T+ +P     P   S   PS    ++ A  QG + +      E + + + P    LP  +
Sbjct: 2405 TLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATEPRPHRGELSPSFLNPP---LPPSI 2461

Query: 1164 DPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTR 1223
            D + L+       E++   G+ G    +G P         GT  G  P   +T   P T 
Sbjct: 2462 DDRDLST------EEVRLVGRGGR-RRVGGP---------GTTGGPCP---VTDETPPTS 2502

Query: 1224 VPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGH 1283
              SDS  +   S     P +            E+ PS       DS   G  +   K G 
Sbjct: 2503 A-SDSGSSQSDS---DVPPET-----------EECPSITAEAALDSDEDGDFLPVDKAGG 2547

Query: 1284 VLSYEG---GMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGR 1340
            V        G       + D R S   P    A         GRV R      ++G +GR
Sbjct: 2548 VSGTHHPRPGHDPPPLPQPDPRPSPPRPDVCMADPEGLSSESGRVERLREKEKVQGRVGR 2607

Query: 1341 AIP 1343
              P
Sbjct: 2608 RAP 2610



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 140/624 (22%), Positives = 206/624 (33%), Gaps = 138/624 (22%)

Query: 1534 PVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRLQEGSL---SSSKASQDR 1590
            P + P    PR +P+  +    P  G++   SP   R P+P+    S    S+S +  ++
Sbjct: 2055 PSLTPPAVPPR-APILSKGPSPPLNGNILSCSP-DRRSPSPKESGRSHWDDSTSDSELEK 2112

Query: 1591 KLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPL 1650
                 P + A+SP        PHPI      L   +      +H+    D    P    L
Sbjct: 2113 GAREQPEKEAQSPSP------PHPIPMGSPTLWPET-----EAHVSPPLDSHLGPARPSL 2161

Query: 1651 DAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAATAM 1710
            D  A+ +    L P P  P L  P   R  P                           ++
Sbjct: 2162 DFPASAFGFSSLQPAP--PQLPSPAEPRSAP-------------------------CGSL 2194

Query: 1711 AQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPT 1770
            A   D    L+P   +   +        +++++ P L   +P  P   +     L+ LP 
Sbjct: 2195 AFSGDRALALAPGPPTRTRHDE-----YLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLP- 2248

Query: 1771 APQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEH 1830
                   R +S  LS G  +  T P  +S +ER                           
Sbjct: 2249 -------RPASPALSEGSSSEATTPVISSVAER--------------------------- 2274

Query: 1831 APIWRPGTEQSSGSSGSSGGGGGSSSRPASHS--HAHQHSPISPRTQD-ALQQRPSVLHN 1887
               + P  E +   SG    G      PA+HS       SP  P + D AL   PS+  +
Sbjct: 2275 ---FSPSLEAAEQESGELDPG----MEPAAHSLWDLTPLSPAPPASLDLALAPAPSLPGD 2327

Query: 1888 TGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPK 1947
             G  GI+       P  L   S ++  +P+    P+  C   G      PT   P   P 
Sbjct: 2328 MG-DGIL-------PCHL-ECSEAATEKPSPFQVPSEDCAANG------PTETSP-NPPG 2371

Query: 1948 EAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPV--SGHATIARTP 2005
             AP  A  E   A       A P    G E +S P     P   V P   SG    + +P
Sbjct: 2372 PAPAKAENEEAAACPAWERGAWP---EGAERSSRPDTLLSPEQPVCPAGGSGGPPSSASP 2428

Query: 2006 AKNLAPHHASPDP-----PAPPASASDPHREKTQSKPFSIQELEL------RSLGYHGSS 2054
                 P   + +P        P+  + P       +  S +E+ L      R +G  G++
Sbjct: 2429 EVEAGPQGCATEPRPHRGELSPSFLNPPLPPSIDDRDLSTEEVRLVGRGGRRRVGGPGTT 2488

Query: 2055 YSP----EGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG---PVKLGGEA 2107
              P    +   P S   S S   D  +P   EE      E  L   + G   PV   G  
Sbjct: 2489 GGPCPVTDETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGV 2548

Query: 2108 AHLPHLR------PLPESQPSSSP 2125
            +   H R      PLP+  P  SP
Sbjct: 2549 SGTHHPRPGHDPPPLPQPDPRPSP 2572



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 88/394 (22%), Positives = 134/394 (34%), Gaps = 83/394 (21%)

Query: 743  NNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT-----PPPEDIPAPTEPT 797
            +++SD+E       +  K+     P PP  +    P   P T     PP +    P  P+
Sbjct: 2103 DSTSDSELEKGAREQPEKEA--QSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPS 2160

Query: 798  ---PASEATGAPTPPPAPP---SPSAP---------------------PPVVPKEEKEEE 830
               PAS A G  +  PAPP   SP+ P                     PP   + ++  E
Sbjct: 2161 LDFPAS-AFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLE 2219

Query: 831  TAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEG- 889
               AP ++    Q P  +   A        P+ S     A    ++G  +EA        
Sbjct: 2220 VTKAPSLDSSLPQLPSPSSPGA--------PLLSNLPRPASPALSEGSSSEATTPVISSV 2271

Query: 890  ------ALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 943
                  +L+A ++E G        ++ +  D    +      +D A        L+P PS
Sbjct: 2272 AERFSPSLEAAEQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLA--------LAPAPS 2323

Query: 944  LLTPTGD-------PRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPP 996
            L    GD         + A+ +KP   +   +  AA  P  T  + P            P
Sbjct: 2324 LPGDMGDGILPCHLECSEAATEKPSPFQVPSEDCAANGPTETSPNPPG-----------P 2372

Query: 997  APPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCW 1056
            AP   +N +  +    + G+ P G  RS  P      E+PV  PA  +      G PP  
Sbjct: 2373 APAKAENEEAAACPAWERGAWPEGAERSSRPDTLLSPEQPV-CPAGGS------GGPPSS 2425

Query: 1057 TSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHP 1090
             S      P     +  PH  + S     PP  P
Sbjct: 2426 ASPEVEAGPQGCATEPRPHRGELSPSFLNPPLPP 2459



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 86/461 (18%), Positives = 171/461 (37%), Gaps = 54/461 (11%)

Query: 475 KNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEE 534
           ++E  K L +   + +  S++  ++  + ++ + +      +++ K  K+K  +   +E+
Sbjct: 349 RSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEK 408

Query: 535 KPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEE 594
             ++E  K+   KEK +        +K+    + +K A  + +RK              +
Sbjct: 409 ISKLEEKKD---KEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELKKISKPDLK 465

Query: 595 AITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYF 654
             TP+    L   ++    +         +K L    +   A    V   T+S  +    
Sbjct: 466 PFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEPQTPPAQKGTVPLPTISGHRELVL 525

Query: 655 NYKK--RQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSG 712
           +  +   Q+ +E+ ++ +  + ++R+     K  P   +EE      ++       G+ G
Sbjct: 526 SSPEDLTQDFEEMKREERALLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGL-G 584

Query: 713 NEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPAT 772
            EE +++E E +     EVP  + S    +++ ++TE          KDT +   +  A 
Sbjct: 585 QEEHVMKEKELV----PEVPEEQGSKDRGLDSGAETEE--------EKDTWEEKKQREA- 631

Query: 773 LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETA 832
                          E +P  TE    SE             P     V+ K E EE   
Sbjct: 632 ---------------ERLPDRTEAREESE-------------PEVKEDVIEKAELEEMEE 663

Query: 833 AAPPVEEGEEQKPPAAEELAVDTGKAEEPVK-SECTEEAEEGPAKGKDAEAAEATAEGAL 891
             P  EE E+    A +         +EP+K +  + EA  G   G   +A E      L
Sbjct: 664 VHPSDEEEED----ATKAEGFYQKHMQEPLKVTPRSREAFGGRELGLQGKAPEKETSLFL 719

Query: 892 KA-EKKEGGSGRATTAKSSGAPQDSDSSATCSADEV-DEAE 930
            +     G +   +  +    P  S++  T S +E+ DE E
Sbjct: 720 SSLTTPAGATEHVSYIQDETIPGYSETEQTISDEEIHDEPE 760



 Score = 37.7 bits (86), Expect = 0.14
 Identities = 107/511 (20%), Positives = 171/511 (33%), Gaps = 71/511 (13%)

Query: 512  MPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKT 571
            +P   QEE   KEKE   E  EE+           K++  D+  E  +EK+    K ++ 
Sbjct: 580  VPGLGQEEHVMKEKELVPEVPEEQGS---------KDRGLDSGAETEEEKDTWEEKKQRE 630

Query: 572  ANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLLEHG 631
            A    R   R      +E   +E +   + AEL  ME    S   EE+   A+    +H 
Sbjct: 631  AE---RLPDRTEAREESEPEVKEDVI--EKAELEEMEEVHPSDEEEEDATKAEGFYQKH- 684

Query: 632  RNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAAS 691
                    M     V+      F  +      E+  Q K   EKE +        PA A+
Sbjct: 685  --------MQEPLKVTPRSREAFGGR------ELGLQGKAP-EKETSLFLSSLTTPAGAT 729

Query: 692  EEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESI 751
            E  ++   ++DE +       +E E     E +H    E        PA     + T  +
Sbjct: 730  EHVSY---IQDETIPGY----SETEQTISDEEIHDEPEE-------RPAPPRFHTSTYDL 775

Query: 752  PSPHTEAAKDTGQNGPKP-PATLG-ADGPPPGPPTPPPEDIPAP-TEPTPASEATGAPTP 808
            P P      +  Q      PAT G   G P    T P   + AP  E    S AT     
Sbjct: 776  PGPEGAGPFEASQPADSAVPATSGKVYGTPETELTYPTNIVAAPLAEEEHVSSATSITEC 835

Query: 809  PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTE 868
                   ++       E++   +  AP  EE           L +DT  +    ++E T+
Sbjct: 836  DKLSSFATSVA-----EDQSVASLTAPQTEE------TGKSSLLLDTVTSIPSSRTEATQ 884

Query: 869  EAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDE 928
              +  P+ G  +  +    +   K+   E  S    + K         S      +E +E
Sbjct: 885  GLDYVPSAGTISPTSSLEEDKGFKSPPCEDFSVTGESEKRGEIIGKGLSGERAVEEEEEE 944

Query: 929  AEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDA 988
                + +  L  +    TP      +A       L + ++R  +      K+  PP    
Sbjct: 945  TANVEMSEKLCSQYG--TPVFSAPGHALHPGEPALGEAEERCLSPDDSTVKMASPP---- 998

Query: 989  APTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1019
                   P+ PP     P   +P +  S P+
Sbjct: 999  -------PSGPPSATHTPFHQSPVEEKSEPQ 1022



 Score = 36.2 bits (82), Expect = 0.42
 Identities = 26/80 (32%), Positives = 34/80 (42%), Gaps = 12/80 (15%)

Query: 729  NEVPRGECSGPATVNNSSD----TESIPSPHTEAAKDTGQNG-----PKPPATLGADGPP 779
            +E P    S   +  + SD    TE  PS   EAA D+ ++G      K     G   P 
Sbjct: 2496 DETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPR 2555

Query: 780  PG---PPTPPPEDIPAPTEP 796
            PG   PP P P+  P+P  P
Sbjct: 2556 PGHDPPPLPQPDPRPSPPRP 2575



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 27/76 (35%), Positives = 37/76 (48%), Gaps = 12/76 (15%)

Query: 822 VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE 881
           V K  K EE      VEEG ++   A  ELA +  K E+  K    E +E+ P K    E
Sbjct: 331 VSKLAKREEV-----VEEGAKE---ARSELAKELAKTEKKAK----ESSEKPPEKPAKPE 378

Query: 882 AAEATAEGALKAEKKE 897
             +  +  ALKAEK++
Sbjct: 379 RVKTESSEALKAEKRK 394



 Score = 32.3 bits (72), Expect = 6.1
 Identities = 53/236 (22%), Positives = 81/236 (34%), Gaps = 30/236 (12%)

Query: 824  KEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG----KAEEPVKSECTEEAEEGPAKGKD 879
            KE K+E           EE+K    EE   DT     K  +P     T E  +   K K 
Sbjct: 421  KEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELKKISKPDLKPFTPEVRKTLYKAKV 480

Query: 880  AEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLS 939
                +     A++ EK+     +   A+    P  + S              G +  +LS
Sbjct: 481  PGRVKIDRSRAIRGEKELSSEPQTPPAQKGTVPLPTIS--------------GHRELVLS 526

Query: 940  PRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIP-PIVTKVHEPPREDAAPTKPAPPAP 998
                L   T D       ++ L  +Q        P P+ T    PP      T P+ P  
Sbjct: 527  SPEDL---TQDFEEMKREERALLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGL 583

Query: 999  PPPQNLQPES----DAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLP 1050
               +++  E     + P++ GS  RG        A+ E EK  +      EA++LP
Sbjct: 584  GQEEHVMKEKELVPEVPEEQGSKDRGLDSG----AETEEEKDTWEEKKQREAERLP 635


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 110/409 (26%), Positives = 146/409 (35%), Gaps = 44/409 (10%)

Query: 712  GNEEEMVEEAEALHASGNEVPRGECSGPATVNN-SSDTESIPSPHTEAAKDTGQNGPKPP 770
            G  E  V  A  +HA   E P       +T    +S   ++P+P    +       P+ P
Sbjct: 969  GTPEGPVTPATTVHAP--EEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEP 1026

Query: 771  ATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP-------PAPPSPSAPPPVVP 823
             +  A  PPP  PT P   +P P EPT  + A   P  P       P P  P++P   VP
Sbjct: 1027 TSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVP 1086

Query: 824  KEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAA 883
              E+    AAA P    EE   PAA   AV T   EEP          E PA    A A 
Sbjct: 1087 TPEEPTSPAAAVPTP--EEPTSPAA---AVPT--PEEPASPAAAVPTPEEPA--SPAAAV 1137

Query: 884  EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 943
                E A  A         A+ A +   P++S S A       + A        L    S
Sbjct: 1138 PTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTS 1197

Query: 944  LLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAA----PTKPAPPAPP 999
                   P A  +      L++    AA++P       E P   AA    P +P  PA  
Sbjct: 1198 PAASVPTPAAMVA-----TLEEFTSPAASVP-----TSEEPASLAAAVSNPEEPTSPAAA 1247

Query: 1000 PPQNLQPESDA----PQQPGSSPRGKSRSPAPPADKEAE-KPVFFPAFAAEAQKLPGDPP 1054
             P   +P S A      +  SSP     +P  PA   A    +  PA  A A   P    
Sbjct: 1248 VPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPE--- 1304

Query: 1055 CWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHP-LPLGLHDTARPV 1102
               + +P    P   + A P A  P     +P G P L +  H  + P+
Sbjct: 1305 --VAAIPAASVPTPEVPAIPAAAVPPMEEVSPIGVPFLGVSAHTDSVPI 1351



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 108/451 (23%), Positives = 158/451 (35%), Gaps = 44/451 (9%)

Query: 686  APAAASEEAAFPPV---VEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRG-ECSGPAT 741
            A  +A E A  P V   V +     + VS  EE     A A+   G     G      A 
Sbjct: 899  AAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAAL 958

Query: 742  VNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASE 801
                  TE   +P       T  + P+ P T       P  P  P   +P P EPT  S 
Sbjct: 959  AITVPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPT--SP 1016

Query: 802  ATGAPTP-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEE 860
            A   PTP  P  P+ + PPP       EE T+ A  V   EE   PAA   AV T   EE
Sbjct: 1017 AAAVPTPEEPTSPAAAVPPP-------EEPTSPAAAVPTPEEPTSPAA---AVPT--PEE 1064

Query: 861  PVKSECTEEAEEGPAKGKDA--EAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSS 918
            P          E P     A     E T+  A     +E       T+ ++  P   + +
Sbjct: 1065 PTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEE------PTSPAAAVPTPEEPA 1118

Query: 919  ATCSADEVDEAEGGDKNRLLSPR----PSLLTPTGDPRANASPQKPLDLKQLKQRAAAIP 974
            +  +A    E        + +P     P+   PT +  A+A+   P   ++    AAA+P
Sbjct: 1119 SPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTP-EESASPAAAVP 1177

Query: 975  ---------PIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP--QQPGSSPRGKSR 1023
                      +V  + EP    A+   PA       +   P +  P  ++P S     S 
Sbjct: 1178 TPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSN 1237

Query: 1024 SPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFS 1083
               P +   A   +  P  +A A   P +     + +P P  P     A  +  +P++ +
Sbjct: 1238 PEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPA 1297

Query: 1084 YA-PPGHPLPLGLHDTARPVLPRPPTISNPP 1113
             A P      +       P +P  P  + PP
Sbjct: 1298 AAVPTPEVAAIPAASVPTPEVPAIPAAAVPP 1328



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 127/535 (23%), Positives = 175/535 (32%), Gaps = 104/535 (19%)

Query: 790  IPAPTEPT-----PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQK 844
            +P+P E T     PA E T         P        +   E+E+ TAAA  V   E   
Sbjct: 851  LPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVSLEEEDVTAAA--VSAPERAT 908

Query: 845  PPAAEELAVDTGKAEEPVKSECTEEAEEGPA----KGKDAEAAEATAEGALK-----AEK 895
             PA   ++V  G A     S   E A    A    +G  A A  +    AL       E+
Sbjct: 909  VPAVT-VSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAALAITVPITEE 967

Query: 896  KEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANA 955
                 G  T A +  AP++ D++A      V   E         P P    PT    A  
Sbjct: 968  DGTPEGPVTPATTVHAPEEPDTAAV----RVSTPEEPASPAAAVPTPE--EPTSPAAAVP 1021

Query: 956  SPQKPLDLKQLKQRAAAIPP---------IVTKVHEPPREDAA------PTKPAPPAPPP 1000
            +P++P         AAA+PP          V    EP    AA      PT PA   P P
Sbjct: 1022 TPEEPTS------PAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTP 1075

Query: 1001 PQNLQPES--DAPQQPGSSPRGKSRSPAPPADKEAEKPV-FFPAFAAEAQKLPGDPPCWT 1057
             +   P +    P++P +SP     +P  P    A  P    PA  A A   P +P    
Sbjct: 1076 EEPTSPAAAVPTPEEP-TSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPA 1134

Query: 1058 SGLP------FPVP----PREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVL---- 1103
            + +P      FP P    P E   A+   P P   +      P P      A  V     
Sbjct: 1135 AAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEE 1194

Query: 1104 PRPPTISNPPPL---------------ISSAKHPSVLERQIGAISQGMSVQLHVPYSEHA 1148
            P  P  S P P                + +++ P+ L   +    +  S    VP  E  
Sbjct: 1195 PTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEP 1254

Query: 1149 KAPVGPV---------TMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA 1199
             +    V            +P P +P   A      +E  SP      PE   +P A   
Sbjct: 1255 TSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAA--- 1311

Query: 1200 SVLRGTALGSVPGGSITKGIPSTRVP-----SDSAITYRGSITHGTPADVLYKGT 1249
                     SVP   +   IP+  VP     S   + + G   H     +  +GT
Sbjct: 1312 ---------SVPTPEV-PAIPAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGT 1356



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 95/426 (22%), Positives = 138/426 (32%), Gaps = 59/426 (13%)

Query: 813  PSPSAPPPVVPKEEKEEETAAAPPVEEGEE-QKPPAAEELAVDTGKAEEPVKSECTEEAE 871
            PS +A  P V    K+   AA P  EEG      PA E  AV       P +        
Sbjct: 834  PSRTAAVPTV----KDALDAALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIV 889

Query: 872  EGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 931
                +   A A  A     + A       G A  A  S   + + + A     E   A  
Sbjct: 890  SLEEEDVTAAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVA 949

Query: 932  GDKNRLLSPRPSLLTPTGD-PRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAA- 989
            G      SP  + L  T      + +P+ P            + P  T VH P   D A 
Sbjct: 950  G-----FSPEWAALAITVPITEEDGTPEGP------------VTPATT-VHAPEEPDTAA 991

Query: 990  -----PTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAA 1044
                 P +PA PA   P   +P S A   P         +  PP ++        P   A
Sbjct: 992  VRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEE--------PTSPA 1043

Query: 1045 EAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLP 1104
             A   P +P    + +P P  P     A P   +P++ + A P    P     +    +P
Sbjct: 1044 AAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPT----SPAAAVP 1099

Query: 1105 RPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMD 1164
             P   ++P   + + + P+             S    VP  E   +P   V    P P +
Sbjct: 1100 TPEEPTSPAAAVPTPEEPA-------------SPAAAVPTPEEPASPAAAV----PTPEE 1142

Query: 1165 PKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRV 1224
            P   AP     +E  S       PE    P A   +     +  +V         P+  V
Sbjct: 1143 PAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASV 1202

Query: 1225 PSDSAI 1230
            P+ +A+
Sbjct: 1203 PTPAAM 1208



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 77/366 (21%), Positives = 113/366 (30%), Gaps = 70/366 (19%)

Query: 1898 EPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPER 1957
            EP T  V R ++   P  PAA  P                T  EP       P    P  
Sbjct: 986  EPDTAAV-RVSTPEEPASPAAAVP----------------TPEEPTSPAAAVPTPEEPTS 1028

Query: 1958 PRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPD 2017
            P A       A PP      PA++     EP       +  A    TP +  +P  A P 
Sbjct: 1029 PAA-------AVPPPEEPTSPAAAVPTPEEP-------TSPAAAVPTPEEPTSPAAAVPT 1074

Query: 2018 PPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGL 2077
            P  P + A+     +  + P +             +  +PE  EP SP ++     +   
Sbjct: 1075 PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPE--EPASPAAAVPTPEEPAS 1132

Query: 2078 PKHLEELDKSHLEGELRPKQPGP-VKLGGEAAHLPHLRPLPESQPSSSPLLQT------- 2129
            P        + +     P  P P V    E+A      P PE   S +  + T       
Sbjct: 1133 P-------AAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASF 1185

Query: 2130 -------------APGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLY-SFPG 2175
                         A  V     +V   +  +       T   P  L+A +  P   + P 
Sbjct: 1186 AAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPA 1245

Query: 2176 ASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPP 2235
            A+ P L+     +   L P +  +PA   P  E      EP   +      +  EP SP 
Sbjct: 1246 AAVPTLEEPTSSAAAVLTPEELSSPAASVPTPE------EPASPAAAVSNLE--EPASPA 1297

Query: 2236 EGMTEP 2241
              +  P
Sbjct: 1298 AAVPTP 1303


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 134/527 (25%), Positives = 186/527 (35%), Gaps = 88/527 (16%)

Query: 745  SSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPG---PPT---------------PP 786
            S  T+S P+P   AA    Q    PP+ +     P G   P T               P 
Sbjct: 565  SLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPA 624

Query: 787  PEDIPAPTEPTPAS-EATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKP 845
            P+  PA + P P   +   A  PP AP   +A PP     +     A++P  E+    +P
Sbjct: 625  PQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSP--EKIVLGQP 682

Query: 846  PAAEELAVDTG----------------KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEG 889
            P+A   A+ T                  AE P  S         P   +D   A   A+G
Sbjct: 683  PSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKG 742

Query: 890  A-LKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSL--LT 946
            A L  +  +  +  A   +   A        + S     +A  GD   L SP P+     
Sbjct: 743  AGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSR 802

Query: 947  PTGDPRANASP--QKPLDLKQLKQRAAAIPPIVTKVHE----PPREDAAPTKPAPPAPP- 999
            P   P++ + P  + PL      Q    +P I    ++    PP  + APT P PP PP 
Sbjct: 803  PPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPL 862

Query: 1000 PPQNLQPESDAPQQP-----------GSSPRGKSRSPAP-PADKEAEKPVFFPAFAAEAQ 1047
             PQ+  PE   P  P            SS    SR PAP P+D + + P      +    
Sbjct: 863  RPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPP-----SQGPH 917

Query: 1048 KLPGDPPCW----TSGLPFPVPPRE---VIKASPHAPDPSAFSYAPPGHPLPLG--LHDT 1098
            K P  PP          P P PPR    V    P  P P A       H +P G  L + 
Sbjct: 918  KSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKAL--LERFHQVPSGIILQNK 975

Query: 1099 ARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMG 1158
            A      P T ++  PL S A            +  G +         HA AP      G
Sbjct: 976  AGGAPAAPQTSTSLGPLTSPA---------ASVLVSGQAPSGTPTAPSHAPAPAPMAATG 1026

Query: 1159 LP--LPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLR 1203
            LP  LP + K  A  S +    ++    +GP +  G+    + S L+
Sbjct: 1027 LPPLLPAENKAFA--SNLPTLNVAKAASSGPGKPSGLQYESKLSGLK 1071



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 105/457 (22%), Positives = 157/457 (34%), Gaps = 56/457 (12%)

Query: 684  KKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVN 743
            ++ P A + +AA PP     +  + G++ + E++V            + +          
Sbjct: 645  QQPPQAPTPQAAAPPQATTPQ-PSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQE 703

Query: 744  NSSDTESIPSPHTEAAKDTGQNGPKP-----PATLGADGPPPGPPTPPPEDIPAPTEPTP 798
             S    S   PH         + P P     PAT  A G   GP  P  +  PAP    P
Sbjct: 704  RSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIP 763

Query: 799  ASEATGAPTPPPAPPSPSAPP----PVVPKEEKEEETAAAPPVEEGEEQKPPAAEEL-AV 853
            A+     P P  +P  P   P    P +P         + PP       +PP+   L   
Sbjct: 764  AAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPH-PTRPPSRPPSRPQSVSRPPSEPPLHPC 822

Query: 854  DTGKAEEPVKSECTEEAEEG--PAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGA 911
               +A   +      + + G  P     A  A    +  L+ + +           +   
Sbjct: 823  PPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQ---PPEGPLPPAPHL 879

Query: 912  PQDSDSSATCSADEVDEAEGGDKNRLLSPRPS----LLTPTGDPRANASPQKPLDLKQLK 967
            P  S SSA  S+ E         +RL +P PS       P+  P  + SP  P  L  + 
Sbjct: 880  PPSSTSSAVASSSET-------SSRLPAPTPSDFQLQFPPSQGP--HKSPTPPPTLHLVP 930

Query: 968  QRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPR-- 1019
            + AA  PP       PPR     T P P  P P   L+     P       + G +P   
Sbjct: 931  EPAAPPPP-------PPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAP 983

Query: 1020 ------GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS 1073
                  G   SPA       + P   P   + A   P   P   +GLP P+ P E    +
Sbjct: 984  QTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHA---PAPAPMAATGLP-PLLPAENKAFA 1039

Query: 1074 PHAPDPSAFSYAPPGHPLPLGL-HDTARPVLPRPPTI 1109
             + P  +    A  G   P GL +++    L +PPT+
Sbjct: 1040 SNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTL 1076



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 52/177 (29%), Positives = 66/177 (37%), Gaps = 29/177 (16%)

Query: 759  AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAP---PSP 815
            A D     P PPATL    PPP PP PPP        PT     T    PP AP   P  
Sbjct: 1326 ALDPVHQPPPPPATLKVAEPPPRPPPPPP--------PTGQMNGTVDHPPPAAPERKPLG 1377

Query: 816  SAPP-PVVPKEEKEEETAAAPPVEEG----------EEQKPPAAEELAVDTGKAEEPVKS 864
            +AP  P +P  +   E    P   EG              P   +E      +    V+ 
Sbjct: 1378 TAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVED 1437

Query: 865  ECTEEAEEGPAKGKDAEAAEAT------AEGALKAEKKEGGSGRATTAK-SSGAPQD 914
            E  +   +GP     A AA+ T      A G   A++++  S     A  SS +PQD
Sbjct: 1438 ELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQD 1494



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 78/329 (23%), Positives = 108/329 (32%), Gaps = 66/329 (20%)

Query: 1721 SPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHS 1780
            +P   + A   A  P+    L+  P   VL  P   TP   + + +     PQ      S
Sbjct: 650  APTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQ----ERS 705

Query: 1781 SSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQ 1840
              PLS  GP HL+ P                        S++ S       P   P T  
Sbjct: 706  QQPLSAEGP-HLSVPA-----------------------SVIVSAPPPAQDPA--PATPV 739

Query: 1841 SSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNT--GMKGIITAVE 1898
            + G+    G G  +    AS + A Q    +P         PS+ H    G    + +  
Sbjct: 740  AKGA----GLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPH 795

Query: 1899 PSTPTVLRSTSTSSPVRPAATFPPATHCP---LGGTLDGVY----------------PTL 1939
            P+ P     +   S  RP +  PP   CP      TL G++                PT 
Sbjct: 796  PTRPPSRPPSRPQSVSRPPSE-PPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTA 854

Query: 1940 -------MEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLV 1992
                   + P   P E P    P  P + T  A  +     S L PA +PS      P  
Sbjct: 855  PGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRL-PAPTPSDFQLQFP-- 911

Query: 1993 PPVSGHATIARTPAKNLAPHHASPDPPAP 2021
            P    H +    P  +L P  A+P PP P
Sbjct: 912  PSQGPHKSPTPPPTLHLVPEPAAPPPPPP 940



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 41/139 (29%), Positives = 57/139 (41%), Gaps = 21/139 (15%)

Query: 898  GGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASP 957
            GGS   T A++S +   S SS++ +A  +D  E G       P PS   P   P      
Sbjct: 1254 GGSPSVTWARASSSLSSSSSSSS-AASSLDADEDG-------PMPSRNRP---PIKTYEA 1302

Query: 958  QKPLDLKQLKQRAAAIPPIVTK-----VHEPPREDA----APTKPAPPAPPPPQNLQPES 1008
            +  + LK   ++ A +  +V       VH+PP   A    A   P PP PPPP   Q   
Sbjct: 1303 RSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPP-PPPPPTGQMNG 1361

Query: 1009 DAPQQPGSSPRGKSRSPAP 1027
                 P ++P  K    AP
Sbjct: 1362 TVDHPPPAAPERKPLGTAP 1380



 Score = 37.0 bits (84), Expect = 0.25
 Identities = 86/371 (23%), Positives = 117/371 (31%), Gaps = 123/371 (33%)

Query: 1897 VEPSTPTVLRSTSTSSPV---RPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVA 1953
            V+P+TP    +T  ++PV   +PA   PPA   PL   L    P   +P   P   P+ A
Sbjct: 603  VQPATPAA--ATGEAAPVLTVQPAPQAPPAVSTPLPLGLQ--QPQAQQPPQAP--TPQAA 656

Query: 1954 RPER---PRADTGHA------FLAKPPARSGLE--------------------------- 1977
             P +   P+   G A       L +PP+ +                              
Sbjct: 657  APPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHL 716

Query: 1978 --PAS----SPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHRE 2031
              PAS    +P    +P P  P   G     + P    +P       PAP   A+ P   
Sbjct: 717  SVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASP------APAPQIPAAAP--- 767

Query: 2032 KTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2091
                                        ++   P SSPSL H   L       D  HL  
Sbjct: 768  ----------------------------LKGPGPSSSPSLPHQAPLG------DSPHLPS 793

Query: 2092 ELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVIT 2151
                + P            P  RP   S+P S P L   P  +    +  +       + 
Sbjct: 794  PHPTRPPS----------RPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGI------FVI 837

Query: 2152 QDYTRHHPQQLSAPLPA--PLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGS----P 2205
            Q+       QL  P PA  P  + PG   P L  +  P +  LPP  H  P+  S     
Sbjct: 838  QN-------QLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVAS 890

Query: 2206 HSEGGKRSPEP 2216
             SE   R P P
Sbjct: 891  SSETSSRLPAP 901


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 113/468 (24%), Positives = 157/468 (33%), Gaps = 66/468 (14%)

Query: 753  SPHTEAAKDTGQNGPKPPATLGAD-----GPPPGPPTPPPEDIPAPTEPTPASEATGAPT 807
            +P T+ AK   Q     P T  AD        P  P+P    I  PT   P ++  G   
Sbjct: 264  TPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEK 323

Query: 808  PPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 867
              P P  P A P  + K   ++     PPV+     KPPA         +   P K    
Sbjct: 324  SQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---------QPLGPAKPPAQ 374

Query: 868  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 927
            +   E P+  +    A A   G  K   ++ G  +  T +  G P+         +    
Sbjct: 375  QTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPT-QQVGTPKPLAQQPGLQSPA-- 431

Query: 928  EAEGGDKNRLLSPRPSLLT---------------PTGDPRANASPQKPLDLKQLKQRAAA 972
            +A G  K  +  P P  +                PT  P     P KP      +   A 
Sbjct: 432  KAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKP---PPQQPGPAK 488

Query: 973  IPPIVTKVHEPPREDAAPTKPAP--PAPPPPQNLQPESDAP--QQPGSS-PRGKSRSPAP 1027
             PP      +PP +    TKP P  P P  P   QP S  P  QQPGS+ P  +  SPA 
Sbjct: 489  PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548

Query: 1028 PADKEAEKPVFFPAFAAEAQKLPGDPPCW---TSGLPFPVPPR-EVIKASPHAPDPSAFS 1083
            P+ +++ KPV         Q     P      + GLP  + P     +   H P+ + F+
Sbjct: 549  PSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFN 608

Query: 1084 YAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVP 1143
                       L               NP P ++  K    L  Q+     G      VP
Sbjct: 609  TCTECQTTVCSLCG------------FNPNPHLTEVKEWLCLNCQMKRALGGDLAP--VP 654

Query: 1144 YSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESL 1191
             S   K    PVT               S  + +Q SP+  A P + L
Sbjct: 655  SSPQPKLKTAPVT--------TTSAVSKSSPQPQQTSPKKDAAPKQDL 694



 Score = 62.0 bits (149), Expect = 7e-09
 Identities = 123/535 (22%), Positives = 184/535 (34%), Gaps = 98/535 (18%)

Query: 668  QHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHAS 727
            Q  L   +  +  R ++K P  +    +        +++    S      + E  AL A 
Sbjct: 107  QPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAV 166

Query: 728  GNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGP----KPPATLGADGPPPGPP 783
             + V +     P  + + S+     +   +      Q  P    KPP  L    P P P 
Sbjct: 167  SSVVNK---FNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPP--LQQQPPKPIPK 221

Query: 784  TPPPEDIPAPTEPTPASEATGAP----TPPPAPPSPSAPPPVVPKEEKE----EETAAAP 835
               P   P   + TP S ++  P    + PP    P   P   P+ +      +  A+ P
Sbjct: 222  QQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRP 281

Query: 836  PVEE-----GEEQKP----PAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEAT 886
              ++     GE  KP    P+   +   T   + P +    E+++ GPAK        A 
Sbjct: 282  QTKQADIVRGESVKPSLPSPSKPPIQQPT-PGKPPAQQPGHEKSQPGPAK------PPAQ 334

Query: 887  AEGALKAEKKEGGSGR------ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSP 940
              G  K   ++ G+ +       TT   +     +   A  +  E   +E      L  P
Sbjct: 335  PSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQP 394

Query: 941  RPSLLTPTGDPRANASPQK----PLDLKQ---LKQRAAAIPPIVTKVHEP-----PREDA 988
                 TP   P     P +    P  L Q   L+  A A  P  T V +P     P + A
Sbjct: 395  PGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQA 454

Query: 989  ----------APTKPAP----PAPPPPQNLQPESDAPQQPGSS--PRGKSRSPAPPADKE 1032
                       PTKP      PA PPPQ   P    PQQPGS+  P  +  S  PP  + 
Sbjct: 455  GPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQ- 513

Query: 1033 AEKPVFFPAFAAEAQKLPGD--PPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHP 1090
                   P  A  + + PG   PP    G            A P A  PS    +     
Sbjct: 514  -------PGPAKPSPQQPGSTKPPSQQPG-----------SAKPSAQQPSPAKPSAQQST 555

Query: 1091 LPLGLHDTARPVLPRPPTISNPPPLISSAKHP--SVLERQIGAISQGMSVQLHVP 1143
             P+    + +P+  +PPT+S       SAK P    L + I  +     + LHVP
Sbjct: 556  KPVSQTGSGKPL--QPPTVS------PSAKQPPSQGLPKTICPLCNTTELLLHVP 602



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 112/499 (22%), Positives = 180/499 (36%), Gaps = 66/499 (13%)

Query: 674  EKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEA-LHASGNEVP 732
            EK +    K    P+  ++  A  P      ++  G +    + +  A+     +G+E P
Sbjct: 322  EKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKP 381

Query: 733  RGECSGPATVNNSSDTESIPSPHTEAAKDTGQN--GPKPPATL-GADGPPPGP-PTPPPE 788
              E  GP  +         P+     AK   Q    PKP A   G   P   P PT  P 
Sbjct: 382  SSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPV 441

Query: 789  DIPAPTEPTPASEA---------TGAPTPP---PAPPSPSAPPPVVPKEEKEEETAAAPP 836
              P P +  PA +A         TG   PP   P P  P    P   K   ++  +A PP
Sbjct: 442  QQPGPGK-IPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPP 500

Query: 837  VEEGEEQKPPAAEELAVDTGKAE-EPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEK 895
             ++    KPP  +      G A+  P +   T+   + P   K +    + A+ + +   
Sbjct: 501  SQQPGSTKPPPQQ-----PGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQST 555

Query: 896  K---EGGSGR----ATTAKSSGAPQDSDSSAT----CSADE--VDEAEGGDKNRLLSPRP 942
            K   + GSG+     T + S+  P       T    C+  E  +   E  + N     + 
Sbjct: 556  KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQT 615

Query: 943  SLLTPTG-DPRANASPQKP---LDLKQLKQRAAAIPPIVTKVHEPPREDAAP---TKPAP 995
            ++ +  G +P  + +  K    L+ +  +     + P+ +     P+   AP   T    
Sbjct: 616  TVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSS--PQPKLKTAPVTTTSAVS 673

Query: 996  PAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPC 1055
             + P PQ   P+ DA  +   S   + + P PP  K+   P    + +A+A++ P     
Sbjct: 674  KSSPQPQQTSPKKDAAPKQDLSKAPEPKKP-PPLVKQ---PTLHGSPSAKAKQPPE---- 725

Query: 1056 WTSGLPFPVPPREVIKAS-----PHAPD-PSAFSYAPPGHPLPLGLHDTARPVLPRPPTI 1109
                L  P PP+E    S     P A D P       P   L      T +P +P     
Sbjct: 726  -ADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQ 784

Query: 1110 S-----NPPPLISSAKHPS 1123
            S       PPL + +  PS
Sbjct: 785  SQAEEKTTPPLKTDSAKPS 803



 Score = 58.5 bits (140), Expect = 8e-08
 Identities = 92/437 (21%), Positives = 149/437 (34%), Gaps = 48/437 (10%)

Query: 752  PSPHTEAAKDTGQNGPKPPATLGAD-GPPPGPPTPPPEDIPAPT-----EPTPASEATGA 805
            P+PH    K+      +    LG D  P P  P P  +  P  T     + +P  + T +
Sbjct: 625  PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQT-S 683

Query: 806  PTPPPAP-------PSPSAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 856
            P    AP       P P  PPP+V  P         A  P E     KP   +E +V + 
Sbjct: 684  PKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743

Query: 857  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 916
            + + PV  +  ++ +          ++ AT +  + + K +  +   TT      P  +D
Sbjct: 744  QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-----PLKTD 798

Query: 917  SSATCSADEVDEAEGGDKNRLLSPRP---SLLTPTGDPRANASPQKPLDLKQLKQRAAAI 973
            S+    +      +    +    PRP   S +     P + +  QK +D  Q K+     
Sbjct: 799  SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE---- 854

Query: 974  PPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEA 1033
             P   +    P+ DA P     P PP P+    ++    Q    P+ +SR  +       
Sbjct: 855  -PKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSIT 913

Query: 1034 EKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS---PHAPDPSAFSYAPPGHP 1090
            + P          +  P  P    +G  F        +AS     A  P   S + PG P
Sbjct: 914  DAP----------KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAP 963

Query: 1091 LPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKA 1150
            +         P   +PPT   PP     A         +   ++  + +   P +E A  
Sbjct: 964  M------KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPT 1017

Query: 1151 PVGPVTMGLPLPMDPKK 1167
                 T   P P+   K
Sbjct: 1018 VKRTETEKKPPPIKDSK 1034



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 114/547 (20%), Positives = 177/547 (32%), Gaps = 75/547 (13%)

Query: 1741 LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTH--LTKPTTT 1798
            +S+   LP    P     + +M R   L ++  P   + S  P  PG P    L+K  TT
Sbjct: 60   MSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPP---KQSGRPPDPGRPAQPGLSKSRTT 116

Query: 1799 SSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPG--TEQSSGSSGSSGGGGGSSS 1856
             +   E+            ++S   +    EH     PG  +E ++ S+ SS     +  
Sbjct: 117  DTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPF 176

Query: 1857 RPASHSHAHQHSPISPRT-------------QDALQQRPS--VLHNTG-------MKGII 1894
               S S A Q      +              +  LQQ+P   +    G         G  
Sbjct: 177  DLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTP 236

Query: 1895 TAVEPSTPTVLRST--STSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV 1952
             ++    P  ++S    T  P++     P   H  L    D   P   +  ++  E+ + 
Sbjct: 237  KSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP 296

Query: 1953 ARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPH 2012
            + P   +         KPPA+   +P    S+    +P   P      +A+ P     P 
Sbjct: 297  SLPSPSKPPIQQPTPGKPPAQ---QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPV 353

Query: 2013 H--ASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPS 2070
                +  PPA P   + P  ++T S+  S ++   ++L            +P  P   P 
Sbjct: 354  QPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP-GPAKPP- 411

Query: 2071 LTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTA 2130
             T   G PK L +          +P    P K  G     P   P+ +  P   P  Q  
Sbjct: 412  -TQQVGTPKPLAQ----------QPGLQSPAKAPG-----PTKTPVQQPGPGKIPAQQAG 455

Query: 2131 PGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDL---RRPP 2187
            PG    Q              Q      P QL  P   P    PG + P        +PP
Sbjct: 456  PGKTSAQ--------------QTGPTKPPSQLPGPAKPPPQQ-PGPAKPPPQQPGSAKPP 500

Query: 2188 SDL---YLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHS 2244
            S       PPP    PA+ SP   G  + P     S     +         +  T+P   
Sbjct: 501  SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560

Query: 2245 RSAVYPL 2251
              +  PL
Sbjct: 561  TGSGKPL 567



 Score = 49.7 bits (117), Expect = 4e-05
 Identities = 95/390 (24%), Positives = 139/390 (35%), Gaps = 79/390 (20%)

Query: 857  KAEEPVKSECTEE---AEEGPAKGKDAEAAEATAEGALKA--EKKEGGSGRATTAKSSGA 911
            K E PV    + +   +E+ P K    E         L+A  +KKE  + R  ++ S   
Sbjct: 2280 KPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETV 2339

Query: 912  PQDSDSS--ATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 969
                 SS  A    +++              +P+   P+G P  ++ P KP    +    
Sbjct: 2340 FDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSL 2399

Query: 970  AAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR-----GKSRS 1024
              +  P       PP        P PP PPPP    P    P  P +SP+      K  +
Sbjct: 2400 DISAQP-------PP--------PPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLT 2444

Query: 1025 PAPPADKEAEKPVFFPAFAAE------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1078
             A P       P+F      E      +  LP    C T+  P PVPP+           
Sbjct: 2445 VASPV--TTATPLFDAVTTLETTAVLRSNGLPVTRICTTA--PPPVPPK----------- 2489

Query: 1079 PSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP--PPLISSAKHPSVLERQIGAISQGM 1136
            PS+         +P GL  T RP   +PP    P  P L ++ + P+ +  +   +S   
Sbjct: 2490 PSS---------IPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTS 2540

Query: 1137 SVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPR-----GQAGPPESL 1191
            S+ L++  S   K         LP P  P  L+P S     + S            P   
Sbjct: 2541 SMTLNLVTSADYK---------LPSPTSP--LSPHSNKSSPRFSKSLTETYVVITLPSEP 2589

Query: 1192 GVPTAQEASVLRGTALGSVPGGSITKGIPS 1221
            G PT   AS     A+ S P GS +K + S
Sbjct: 2590 GTPTDSSAS----QAITSWPLGSPSKDLVS 2615



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 21/66 (31%)

Query: 773  LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE---EKEE 829
            + A  PPP PP PPP                  P PPP PP P  PPP  PK     K++
Sbjct: 2401 ISAQPPPPPPPPPPP------------------PPPPPPPPPPPLPPPTSPKPTILPKKK 2442

Query: 830  ETAAAP 835
             T A+P
Sbjct: 2443 LTVASP 2448



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 85/467 (18%), Positives = 182/467 (38%), Gaps = 64/467 (13%)

Query: 183  ITMVEQQISKLKKKQQQLEEEAAKPPE--PEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240
            ++++E Q S L  ++    E+  +P E  PE+P      +S   +L   I +E  K+++ 
Sbjct: 1417 LSILEAQASTLADEKS---EKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473

Query: 241  AHRILEGLGPQVELP----------LYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHA 290
              +       Q ++P            +  +  R+ +++++ +       +   KRR   
Sbjct: 1474 ERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSV 1533

Query: 291  RKQWEQKFCQRYDQLMEAWEKKVER--IENNPRRRAKESKVREYYEKQFPEIRKQRELQE 348
                  ++ Q   Q     E  + +  IE +    A  S+  E+   Q  EI    E Q+
Sbjct: 1534 GSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQK 1593

Query: 349  RMQSR-------------VGQRGSGLSMSAAR------SEHEVSEIIDGLSEQENLEKQM 389
            + +++               +  + +   A R       + E  +    L  +E   ++ 
Sbjct: 1594 KEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES 1653

Query: 390  RQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHP- 448
             +L V          +R K I +N  +AD       ++  +++ ++E E   E     P 
Sbjct: 1654 EELVVTG----GGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPE 1709

Query: 449  -KNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQ 507
             ++ G  +S L   +         ++  +E+  S          K + +QQ++ + +   
Sbjct: 1710 DRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHK-----KGESKQQRKARHRPHG 1764

Query: 508  QQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASK 567
               P    S EE++ +E+E+  +++E++ E+E  +    ++ +   S +D DE  A    
Sbjct: 1765 PLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQ----RKSSSKKSKKDKDELRA---- 1816

Query: 568  GRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASM-ELNESS 613
                     RR+ R     +N +  E+A   ++  + A M EL+ SS
Sbjct: 1817 --------QRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSS 1855



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 28/240 (11%)

Query: 809  PPAPPSPSAPPPVVPKEEKEEETAAAPP---VEEGEEQKPPAAEELAVDTGK---AEEPV 862
            PPAP  P A P  VP E   ++TA  P    V++ E++    AE++ ++  K   + E +
Sbjct: 1126 PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKI 1185

Query: 863  KSECTEEAEEGPAKGKDAEAAEATAEGALKAEKK--------EGGSGRATTAKSSGAPQD 914
                T + ++  +K +  +A+    +  L  EKK             +    +    P+D
Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPED 1245

Query: 915  SDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIP 974
                        +E     K+ LL  +  +     + R   +P+   + KQ + +   +P
Sbjct: 1246 KKLLPEAKTSAPEE----QKHDLLKSQVQIAEEKLEGR--VAPKTVQEGKQPQTKMEGLP 1299

Query: 975  PIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPRGKSRSPAPP 1028
                +    P+ED   TK     P PP   +P+   P      ++   S    S+ P  P
Sbjct: 1300 SGTPQ--SLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSP 1357



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 41/179 (22%), Positives = 58/179 (32%), Gaps = 41/179 (22%)

Query: 679  ARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSG 738
            A R KK+  A  ++ +    V +        +   E+       +    G E P  +   
Sbjct: 2319 AYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPS 2378

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 798
             +   +S   +  P   + +   + Q  P PP       PPP PP PPP  +P PT P P
Sbjct: 2379 GSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPP---PPPPPPPPPPPPPPLPPPTSPKP 2435

Query: 799  ----------ASEATGA----------------------------PTPPPAPPSPSAPP 819
                      AS  T A                              PPP PP PS+ P
Sbjct: 2436 TILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIP 2494



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 107/498 (21%), Positives = 161/498 (32%), Gaps = 106/498 (21%)

Query: 787  PEDIPAPTEPTPASEATGAPTPPPAP----------------------------PSPSAP 818
            PE + A       +   G+P+    P                            P  S P
Sbjct: 13   PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72

Query: 819  PPVVPK---EEKEEETAAAPPVEEGEEQKP--PAAEELA----VDTGKAEE--PVKSECT 867
            P          K+E  ++ PP + G    P  PA   L+     DT ++E+  P +S  T
Sbjct: 73   PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132

Query: 868  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSA----TCSA 923
               +E  ++    E  +++      +E     +  +   K +     SDS A    T   
Sbjct: 133  ISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKK 192

Query: 924  DEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD--------LKQLKQRAAAIPP 975
             +V + E G    ++ P      P   P+     + PL           Q  ++  + PP
Sbjct: 193  QKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPP 252

Query: 976  IVTKVHEPP--------------REDAAP------------TKPAPPAP--PPPQNLQPE 1007
               K  + P              R+ + P             KP+ P+P  PP Q   P 
Sbjct: 253  GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG 312

Query: 1008 SDAPQQPG--SSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPV- 1064
                QQPG   S  G ++ PA P+     KP+   A      K P  PP  T     P+ 
Sbjct: 313  KPPAQQPGHEKSQPGPAKPPAQPSG--LTKPL---AQQPGTVKPPVQPPGTTKPPAQPLG 367

Query: 1065 ---PPREVI---KASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPT--------IS 1110
               PP +     K S   P P A +  PPG    +G     +P   +PPT        ++
Sbjct: 368  PAKPPAQQTGSEKPSSEQPGPKALA-QPPG----VGKTPAQQPGPAKPPTQQVGTPKPLA 422

Query: 1111 NPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAP 1170
              P L S AK P   +  +     G          + +    GP      LP   K    
Sbjct: 423  QQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQ 482

Query: 1171 FSGVKQEQLSPRGQAGPP 1188
              G  +      G A PP
Sbjct: 483  QPGPAKPPPQQPGSAKPP 500



 Score = 41.2 bits (95), Expect = 0.013
 Identities = 61/299 (20%), Positives = 96/299 (32%), Gaps = 18/299 (6%)

Query: 741  TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTE----P 796
            T +  S + +   P   ++K   Q   K    L  D   P    PP  +  +P +    P
Sbjct: 763  TTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIP 822

Query: 797  TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 856
             PAS++     P P+  S      V P ++KEE   A   +    + KP         T 
Sbjct: 823  RPASDSKIISHPGPSSES-KGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGS---PTP 878

Query: 857  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRAT-TAKSSGA---- 911
                P   +     ++ P   + +            A K +  + + T T K  G     
Sbjct: 879  PGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASI 938

Query: 912  -PQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRA 970
              Q S+  +T          G       +P PS    +  P  +     P   K +  + 
Sbjct: 939  FSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK 998

Query: 971  AAIPPIVTKVHEPPREDAAPT--KPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP 1027
                P   K+   P+ + APT  +      PPP        A  Q    P    +SP P
Sbjct: 999  ETKAPAAEKLE--PKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP 1055



 Score = 40.8 bits (94), Expect = 0.017
 Identities = 79/369 (21%), Positives = 131/369 (35%), Gaps = 56/369 (15%)

Query: 509  QQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKED---LLKEKTDDTSGEDNDEKEAVA 565
            +QP P +    K    KE     E++K  V +DK     ++K  TD  S      K  + 
Sbjct: 721  KQP-PEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIP 779

Query: 566  SKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKK 625
            S                      ++ +EE  TP    +  S + ++S   T E++     
Sbjct: 780  SS-------------------KVQSQAEEKTTPPLKTD--SAKPSQSFPPTGEKVSPFDS 818

Query: 626  GLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKK 685
              +    + S I    G  + S         K ++ +D + ++ + K  + + + +   K
Sbjct: 819  KAIPRPASDSKIISHPGPSSES---------KGQKQVDPVQKKEEPKKAQTKMSPKPDAK 869

Query: 686  APAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPA-TVNN 744
                 S     P     + +     S   +E          S  + P+ + + P  TV  
Sbjct: 870  PMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTG 929

Query: 745  S--SDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEA 802
                   SI S  +      GQ GP   +  GA          P +  PAP++P P S+ 
Sbjct: 930  KLFGFGASIFSQASNLISTAGQPGPHSQSGPGA----------PMKQAPAPSQP-PTSQG 978

Query: 803  TGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPV 862
                T   APP+P+   PV    +KE +  AA  +E   EQ P        +T K   P+
Sbjct: 979  PPKSTGQ-APPAPAKSIPV----KKETKAPAAEKLEPKAEQAPTVKR---TETEKKPPPI 1030

Query: 863  KSECTEEAE 871
            K   +  AE
Sbjct: 1031 KDSKSLTAE 1039



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 49/218 (22%), Positives = 84/218 (38%), Gaps = 29/218 (13%)

Query: 667  QQHKLKMEKER-NARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALH 725
            +Q + K+EK++ +A ++KK  P    EE    P  E+E++     S  ++ ++EE +   
Sbjct: 1194 KQEESKLEKDKASALQEKKPLP----EEKKLIP--EEEKIR----SEEKKPLLEEKKPTP 1243

Query: 726  ASGNEVPRGECSGPATVNNSSDTESIPSPHTE----AAKDTGQNGPKPPATLGADGPPPG 781
                 +P  + S P    +      +     +     A  T Q G +P   +       G
Sbjct: 1244 EDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKM------EG 1297

Query: 782  PPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGE 841
             P+  P+ +P   + T     T      P PP  + P  V P +EK E+          +
Sbjct: 1298 LPSGTPQSLPKEDDKT-----TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQ 1352

Query: 842  EQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD 879
            + K P       DTG + + + S   E     P   KD
Sbjct: 1353 QPKSPQG---LSDTGYSSDGISSSLGEIPSLIPTDEKD 1387



 Score = 38.9 bits (89), Expect = 0.065
 Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 40/245 (16%)

Query: 1396 PSRDLTEAYKTQALGPLKLKPAHEGLVATV-----------KEAGRSIHEIPREELR--- 1441
            P +DL++A + +   PL  +P   G  +             K A      +P E+ +   
Sbjct: 690  PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749

Query: 1442 --HTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHD-----VRSLIGSPGRTFPPV 1494
                P+ P   +P  +   +     K D  +S   S+  +     +++    P ++FPP 
Sbjct: 750  ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT 809

Query: 1495 HPLDVMADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHG 1554
                   D++A+ R   +  + S PG +S S G   +  PV   E  K  Q+ ++ +   
Sbjct: 810  GEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQ-KQVDPVQKKEEPKKAQTKMSPK--- 865

Query: 1555 APFAGHLPRGSP------------VTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKS 1602
             P A  +P+GSP            V T + +P+ QE S   S       +T  P+    +
Sbjct: 866  -PDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFS--LNLGSITDAPKSQPTT 922

Query: 1603 PHSTV 1607
            P  TV
Sbjct: 923  PQETV 927



 Score = 38.9 bits (89), Expect = 0.065
 Identities = 21/72 (29%), Positives = 28/72 (38%), Gaps = 6/72 (8%)

Query: 772  TLGADGPPPGPPTPPPEDIPAPTEPTPASEATGA------PTPPPAPPSPSAPPPVVPKE 825
            T G + P    P+  P     P +P P   ++        P PPP PP P  PPP  P  
Sbjct: 2366 TFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPP 2425

Query: 826  EKEEETAAAPPV 837
                 T+  P +
Sbjct: 2426 PLPPPTSPKPTI 2437



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 77/367 (20%), Positives = 115/367 (31%), Gaps = 55/367 (14%)

Query: 1946 PKEAPRVARPERPRA-------DTGHAFLAKPPARSGLEPASS--PSKGSEPRPLVPPVS 1996
            P EA  +++P  P+        D       KP     ++P +    S  +  +P +P   
Sbjct: 723  PPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK 782

Query: 1997 GHATIARTPAKNLAPHHASPDPPAPPASAS-DPHREKTQSKPFSIQELELRSLGYHGSSY 2055
              +         L    A P    PP      P   K   +P S  ++ +   G    S 
Sbjct: 783  VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKI-ISHPGPSSESK 841

Query: 2056 SPEGVEPVSPVSSPSLTHDKGLPK-HLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLR 2114
              + V+PV     P     K  PK   + + K        P  PGP    G+    P   
Sbjct: 842  GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGS------PTPPGPRPTAGQTVPTPQQS 895

Query: 2115 PLPESQ--------------PSSSPLL--QTAPGVKGHQRVVTLAQHISEVITQDYTRHH 2158
            P P+ Q              P S P    +T  G          +Q  + + T      H
Sbjct: 896  PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPH 955

Query: 2159 PQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE------GGKR 2212
             Q  S P  AP+   P  S P      P S    PP    APA+  P  +        K 
Sbjct: 956  SQ--SGP-GAPMKQAPAPSQPPTSQGPPKSTGQAPP----APAKSIPVKKETKAPAAEKL 1008

Query: 2213 SPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPS--------RM 2264
             P+  +   +   E   +P    +  +     + AV P       + E +         +
Sbjct: 1009 EPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNI 1068

Query: 2265 GSKSPGN 2271
            GSK P N
Sbjct: 1069 GSKDPPN 1075



 Score = 34.3 bits (77), Expect = 1.6
 Identities = 14/37 (37%), Positives = 30/37 (81%), Gaps = 3/37 (8%)

Query: 167  LSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEE 203
            +++ +++Q+   +DRE+ +VE++ +KL+KKQ +L+EE
Sbjct: 3757 MARAKILQD---IDRELDLVERESAKLRKKQAELDEE 3790


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 113/468 (24%), Positives = 157/468 (33%), Gaps = 66/468 (14%)

Query: 753  SPHTEAAKDTGQNGPKPPATLGAD-----GPPPGPPTPPPEDIPAPTEPTPASEATGAPT 807
            +P T+ AK   Q     P T  AD        P  P+P    I  PT   P ++  G   
Sbjct: 264  TPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEK 323

Query: 808  PPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 867
              P P  P A P  + K   ++     PPV+     KPPA         +   P K    
Sbjct: 324  SQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---------QPLGPAKPPAQ 374

Query: 868  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 927
            +   E P+  +    A A   G  K   ++ G  +  T +  G P+         +    
Sbjct: 375  QTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPT-QQVGTPKPLAQQPGLQSPA-- 431

Query: 928  EAEGGDKNRLLSPRPSLLT---------------PTGDPRANASPQKPLDLKQLKQRAAA 972
            +A G  K  +  P P  +                PT  P     P KP      +   A 
Sbjct: 432  KAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKP---PPQQPGPAK 488

Query: 973  IPPIVTKVHEPPREDAAPTKPAP--PAPPPPQNLQPESDAP--QQPGSS-PRGKSRSPAP 1027
             PP      +PP +    TKP P  P P  P   QP S  P  QQPGS+ P  +  SPA 
Sbjct: 489  PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548

Query: 1028 PADKEAEKPVFFPAFAAEAQKLPGDPPCW---TSGLPFPVPPR-EVIKASPHAPDPSAFS 1083
            P+ +++ KPV         Q     P      + GLP  + P     +   H P+ + F+
Sbjct: 549  PSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFN 608

Query: 1084 YAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVP 1143
                       L               NP P ++  K    L  Q+     G      VP
Sbjct: 609  TCTECQTTVCSLCG------------FNPNPHLTEVKEWLCLNCQMKRALGGDLAP--VP 654

Query: 1144 YSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESL 1191
             S   K    PVT               S  + +Q SP+  A P + L
Sbjct: 655  SSPQPKLKTAPVT--------TTSAVSKSSPQPQQTSPKKDAAPKQDL 694



 Score = 62.0 bits (149), Expect = 7e-09
 Identities = 123/535 (22%), Positives = 184/535 (34%), Gaps = 98/535 (18%)

Query: 668  QHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHAS 727
            Q  L   +  +  R ++K P  +    +        +++    S      + E  AL A 
Sbjct: 107  QPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAV 166

Query: 728  GNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGP----KPPATLGADGPPPGPP 783
             + V +     P  + + S+     +   +      Q  P    KPP  L    P P P 
Sbjct: 167  SSVVNK---FNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPP--LQQQPPKPIPK 221

Query: 784  TPPPEDIPAPTEPTPASEATGAP----TPPPAPPSPSAPPPVVPKEEKE----EETAAAP 835
               P   P   + TP S ++  P    + PP    P   P   P+ +      +  A+ P
Sbjct: 222  QQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRP 281

Query: 836  PVEE-----GEEQKP----PAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEAT 886
              ++     GE  KP    P+   +   T   + P +    E+++ GPAK        A 
Sbjct: 282  QTKQADIVRGESVKPSLPSPSKPPIQQPT-PGKPPAQQPGHEKSQPGPAK------PPAQ 334

Query: 887  AEGALKAEKKEGGSGR------ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSP 940
              G  K   ++ G+ +       TT   +     +   A  +  E   +E      L  P
Sbjct: 335  PSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQP 394

Query: 941  RPSLLTPTGDPRANASPQK----PLDLKQ---LKQRAAAIPPIVTKVHEP-----PREDA 988
                 TP   P     P +    P  L Q   L+  A A  P  T V +P     P + A
Sbjct: 395  PGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQA 454

Query: 989  ----------APTKPAP----PAPPPPQNLQPESDAPQQPGSS--PRGKSRSPAPPADKE 1032
                       PTKP      PA PPPQ   P    PQQPGS+  P  +  S  PP  + 
Sbjct: 455  GPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQ- 513

Query: 1033 AEKPVFFPAFAAEAQKLPGD--PPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHP 1090
                   P  A  + + PG   PP    G            A P A  PS    +     
Sbjct: 514  -------PGPAKPSPQQPGSTKPPSQQPG-----------SAKPSAQQPSPAKPSAQQST 555

Query: 1091 LPLGLHDTARPVLPRPPTISNPPPLISSAKHP--SVLERQIGAISQGMSVQLHVP 1143
             P+    + +P+  +PPT+S       SAK P    L + I  +     + LHVP
Sbjct: 556  KPVSQTGSGKPL--QPPTVS------PSAKQPPSQGLPKTICPLCNTTELLLHVP 602



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 112/499 (22%), Positives = 180/499 (36%), Gaps = 66/499 (13%)

Query: 674  EKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEA-LHASGNEVP 732
            EK +    K    P+  ++  A  P      ++  G +    + +  A+     +G+E P
Sbjct: 322  EKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKP 381

Query: 733  RGECSGPATVNNSSDTESIPSPHTEAAKDTGQN--GPKPPATL-GADGPPPGP-PTPPPE 788
              E  GP  +         P+     AK   Q    PKP A   G   P   P PT  P 
Sbjct: 382  SSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPV 441

Query: 789  DIPAPTEPTPASEA---------TGAPTPP---PAPPSPSAPPPVVPKEEKEEETAAAPP 836
              P P +  PA +A         TG   PP   P P  P    P   K   ++  +A PP
Sbjct: 442  QQPGPGK-IPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPP 500

Query: 837  VEEGEEQKPPAAEELAVDTGKAE-EPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEK 895
             ++    KPP  +      G A+  P +   T+   + P   K +    + A+ + +   
Sbjct: 501  SQQPGSTKPPPQQ-----PGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQST 555

Query: 896  K---EGGSGR----ATTAKSSGAPQDSDSSAT----CSADE--VDEAEGGDKNRLLSPRP 942
            K   + GSG+     T + S+  P       T    C+  E  +   E  + N     + 
Sbjct: 556  KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQT 615

Query: 943  SLLTPTG-DPRANASPQKP---LDLKQLKQRAAAIPPIVTKVHEPPREDAAP---TKPAP 995
            ++ +  G +P  + +  K    L+ +  +     + P+ +     P+   AP   T    
Sbjct: 616  TVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSS--PQPKLKTAPVTTTSAVS 673

Query: 996  PAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPC 1055
             + P PQ   P+ DA  +   S   + + P PP  K+   P    + +A+A++ P     
Sbjct: 674  KSSPQPQQTSPKKDAAPKQDLSKAPEPKKP-PPLVKQ---PTLHGSPSAKAKQPPE---- 725

Query: 1056 WTSGLPFPVPPREVIKAS-----PHAPD-PSAFSYAPPGHPLPLGLHDTARPVLPRPPTI 1109
                L  P PP+E    S     P A D P       P   L      T +P +P     
Sbjct: 726  -ADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQ 784

Query: 1110 S-----NPPPLISSAKHPS 1123
            S       PPL + +  PS
Sbjct: 785  SQAEEKTTPPLKTDSAKPS 803



 Score = 58.5 bits (140), Expect = 8e-08
 Identities = 92/437 (21%), Positives = 149/437 (34%), Gaps = 48/437 (10%)

Query: 752  PSPHTEAAKDTGQNGPKPPATLGAD-GPPPGPPTPPPEDIPAPT-----EPTPASEATGA 805
            P+PH    K+      +    LG D  P P  P P  +  P  T     + +P  + T +
Sbjct: 625  PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQT-S 683

Query: 806  PTPPPAP-------PSPSAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 856
            P    AP       P P  PPP+V  P         A  P E     KP   +E +V + 
Sbjct: 684  PKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743

Query: 857  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 916
            + + PV  +  ++ +          ++ AT +  + + K +  +   TT      P  +D
Sbjct: 744  QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-----PLKTD 798

Query: 917  SSATCSADEVDEAEGGDKNRLLSPRP---SLLTPTGDPRANASPQKPLDLKQLKQRAAAI 973
            S+    +      +    +    PRP   S +     P + +  QK +D  Q K+     
Sbjct: 799  SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE---- 854

Query: 974  PPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEA 1033
             P   +    P+ DA P     P PP P+    ++    Q    P+ +SR  +       
Sbjct: 855  -PKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSIT 913

Query: 1034 EKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS---PHAPDPSAFSYAPPGHP 1090
            + P          +  P  P    +G  F        +AS     A  P   S + PG P
Sbjct: 914  DAP----------KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAP 963

Query: 1091 LPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKA 1150
            +         P   +PPT   PP     A         +   ++  + +   P +E A  
Sbjct: 964  M------KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPT 1017

Query: 1151 PVGPVTMGLPLPMDPKK 1167
                 T   P P+   K
Sbjct: 1018 VKRTETEKKPPPIKDSK 1034



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 114/547 (20%), Positives = 177/547 (32%), Gaps = 75/547 (13%)

Query: 1741 LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTH--LTKPTTT 1798
            +S+   LP    P     + +M R   L ++  P   + S  P  PG P    L+K  TT
Sbjct: 60   MSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPP---KQSGRPPDPGRPAQPGLSKSRTT 116

Query: 1799 SSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPG--TEQSSGSSGSSGGGGGSSS 1856
             +   E+            ++S   +    EH     PG  +E ++ S+ SS     +  
Sbjct: 117  DTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPF 176

Query: 1857 RPASHSHAHQHSPISPRT-------------QDALQQRPS--VLHNTG-------MKGII 1894
               S S A Q      +              +  LQQ+P   +    G         G  
Sbjct: 177  DLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTP 236

Query: 1895 TAVEPSTPTVLRST--STSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV 1952
             ++    P  ++S    T  P++     P   H  L    D   P   +  ++  E+ + 
Sbjct: 237  KSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP 296

Query: 1953 ARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPH 2012
            + P   +         KPPA+   +P    S+    +P   P      +A+ P     P 
Sbjct: 297  SLPSPSKPPIQQPTPGKPPAQ---QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPV 353

Query: 2013 H--ASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPS 2070
                +  PPA P   + P  ++T S+  S ++   ++L            +P  P   P 
Sbjct: 354  QPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP-GPAKPP- 411

Query: 2071 LTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTA 2130
             T   G PK L +          +P    P K  G     P   P+ +  P   P  Q  
Sbjct: 412  -TQQVGTPKPLAQ----------QPGLQSPAKAPG-----PTKTPVQQPGPGKIPAQQAG 455

Query: 2131 PGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDL---RRPP 2187
            PG    Q              Q      P QL  P   P    PG + P        +PP
Sbjct: 456  PGKTSAQ--------------QTGPTKPPSQLPGPAKPPPQQ-PGPAKPPPQQPGSAKPP 500

Query: 2188 SDL---YLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHS 2244
            S       PPP    PA+ SP   G  + P     S     +         +  T+P   
Sbjct: 501  SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560

Query: 2245 RSAVYPL 2251
              +  PL
Sbjct: 561  TGSGKPL 567



 Score = 49.7 bits (117), Expect = 4e-05
 Identities = 95/390 (24%), Positives = 139/390 (35%), Gaps = 79/390 (20%)

Query: 857  KAEEPVKSECTEE---AEEGPAKGKDAEAAEATAEGALKA--EKKEGGSGRATTAKSSGA 911
            K E PV    + +   +E+ P K    E         L+A  +KKE  + R  ++ S   
Sbjct: 2280 KPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETV 2339

Query: 912  PQDSDSS--ATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 969
                 SS  A    +++              +P+   P+G P  ++ P KP    +    
Sbjct: 2340 FDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSL 2399

Query: 970  AAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR-----GKSRS 1024
              +  P       PP        P PP PPPP    P    P  P +SP+      K  +
Sbjct: 2400 DISAQP-------PP--------PPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLT 2444

Query: 1025 PAPPADKEAEKPVFFPAFAAE------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1078
             A P       P+F      E      +  LP    C T+  P PVPP+           
Sbjct: 2445 VASPV--TTATPLFDAVTTLETTAVLRSNGLPVTRICTTA--PPPVPPK----------- 2489

Query: 1079 PSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP--PPLISSAKHPSVLERQIGAISQGM 1136
            PS+         +P GL  T RP   +PP    P  P L ++ + P+ +  +   +S   
Sbjct: 2490 PSS---------IPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTS 2540

Query: 1137 SVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPR-----GQAGPPESL 1191
            S+ L++  S   K         LP P  P  L+P S     + S            P   
Sbjct: 2541 SMTLNLVTSADYK---------LPSPTSP--LSPHSNKSSPRFSKSLTETYVVITLPSEP 2589

Query: 1192 GVPTAQEASVLRGTALGSVPGGSITKGIPS 1221
            G PT   AS     A+ S P GS +K + S
Sbjct: 2590 GTPTDSSAS----QAITSWPLGSPSKDLVS 2615



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 21/66 (31%)

Query: 773  LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE---EKEE 829
            + A  PPP PP PPP                  P PPP PP P  PPP  PK     K++
Sbjct: 2401 ISAQPPPPPPPPPPP------------------PPPPPPPPPPPLPPPTSPKPTILPKKK 2442

Query: 830  ETAAAP 835
             T A+P
Sbjct: 2443 LTVASP 2448



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 85/467 (18%), Positives = 182/467 (38%), Gaps = 64/467 (13%)

Query: 183  ITMVEQQISKLKKKQQQLEEEAAKPPE--PEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240
            ++++E Q S L  ++    E+  +P E  PE+P      +S   +L   I +E  K+++ 
Sbjct: 1417 LSILEAQASTLADEKS---EKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473

Query: 241  AHRILEGLGPQVELP----------LYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHA 290
              +       Q ++P            +  +  R+ +++++ +       +   KRR   
Sbjct: 1474 ERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSV 1533

Query: 291  RKQWEQKFCQRYDQLMEAWEKKVER--IENNPRRRAKESKVREYYEKQFPEIRKQRELQE 348
                  ++ Q   Q     E  + +  IE +    A  S+  E+   Q  EI    E Q+
Sbjct: 1534 GSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQK 1593

Query: 349  RMQSR-------------VGQRGSGLSMSAAR------SEHEVSEIIDGLSEQENLEKQM 389
            + +++               +  + +   A R       + E  +    L  +E   ++ 
Sbjct: 1594 KEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES 1653

Query: 390  RQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHP- 448
             +L V          +R K I +N  +AD       ++  +++ ++E E   E     P 
Sbjct: 1654 EELVVTG----GGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPE 1709

Query: 449  -KNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQ 507
             ++ G  +S L   +         ++  +E+  S          K + +QQ++ + +   
Sbjct: 1710 DRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHK-----KGESKQQRKARHRPHG 1764

Query: 508  QQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASK 567
               P    S EE++ +E+E+  +++E++ E+E  +    ++ +   S +D DE  A    
Sbjct: 1765 PLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQ----RKSSSKKSKKDKDELRA---- 1816

Query: 568  GRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASM-ELNESS 613
                     RR+ R     +N +  E+A   ++  + A M EL+ SS
Sbjct: 1817 --------QRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSS 1855



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 28/240 (11%)

Query: 809  PPAPPSPSAPPPVVPKEEKEEETAAAPP---VEEGEEQKPPAAEELAVDTGK---AEEPV 862
            PPAP  P A P  VP E   ++TA  P    V++ E++    AE++ ++  K   + E +
Sbjct: 1126 PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKI 1185

Query: 863  KSECTEEAEEGPAKGKDAEAAEATAEGALKAEKK--------EGGSGRATTAKSSGAPQD 914
                T + ++  +K +  +A+    +  L  EKK             +    +    P+D
Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPED 1245

Query: 915  SDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIP 974
                        +E     K+ LL  +  +     + R   +P+   + KQ + +   +P
Sbjct: 1246 KKLLPEAKTSAPEE----QKHDLLKSQVQIAEEKLEGR--VAPKTVQEGKQPQTKMEGLP 1299

Query: 975  PIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPRGKSRSPAPP 1028
                +    P+ED   TK     P PP   +P+   P      ++   S    S+ P  P
Sbjct: 1300 SGTPQ--SLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSP 1357



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 41/179 (22%), Positives = 58/179 (32%), Gaps = 41/179 (22%)

Query: 679  ARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSG 738
            A R KK+  A  ++ +    V +        +   E+       +    G E P  +   
Sbjct: 2319 AYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPS 2378

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 798
             +   +S   +  P   + +   + Q  P PP       PPP PP PPP  +P PT P P
Sbjct: 2379 GSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPP---PPPPPPPPPPPPPPLPPPTSPKP 2435

Query: 799  ----------ASEATGA----------------------------PTPPPAPPSPSAPP 819
                      AS  T A                              PPP PP PS+ P
Sbjct: 2436 TILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIP 2494



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 107/498 (21%), Positives = 161/498 (32%), Gaps = 106/498 (21%)

Query: 787  PEDIPAPTEPTPASEATGAPTPPPAP----------------------------PSPSAP 818
            PE + A       +   G+P+    P                            P  S P
Sbjct: 13   PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72

Query: 819  PPVVPK---EEKEEETAAAPPVEEGEEQKP--PAAEELA----VDTGKAEE--PVKSECT 867
            P          K+E  ++ PP + G    P  PA   L+     DT ++E+  P +S  T
Sbjct: 73   PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132

Query: 868  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSA----TCSA 923
               +E  ++    E  +++      +E     +  +   K +     SDS A    T   
Sbjct: 133  ISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKK 192

Query: 924  DEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD--------LKQLKQRAAAIPP 975
             +V + E G    ++ P      P   P+     + PL           Q  ++  + PP
Sbjct: 193  QKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPP 252

Query: 976  IVTKVHEPP--------------REDAAP------------TKPAPPAP--PPPQNLQPE 1007
               K  + P              R+ + P             KP+ P+P  PP Q   P 
Sbjct: 253  GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG 312

Query: 1008 SDAPQQPG--SSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPV- 1064
                QQPG   S  G ++ PA P+     KP+   A      K P  PP  T     P+ 
Sbjct: 313  KPPAQQPGHEKSQPGPAKPPAQPSG--LTKPL---AQQPGTVKPPVQPPGTTKPPAQPLG 367

Query: 1065 ---PPREVI---KASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPT--------IS 1110
               PP +     K S   P P A +  PPG    +G     +P   +PPT        ++
Sbjct: 368  PAKPPAQQTGSEKPSSEQPGPKALA-QPPG----VGKTPAQQPGPAKPPTQQVGTPKPLA 422

Query: 1111 NPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAP 1170
              P L S AK P   +  +     G          + +    GP      LP   K    
Sbjct: 423  QQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQ 482

Query: 1171 FSGVKQEQLSPRGQAGPP 1188
              G  +      G A PP
Sbjct: 483  QPGPAKPPPQQPGSAKPP 500



 Score = 41.2 bits (95), Expect = 0.013
 Identities = 61/299 (20%), Positives = 96/299 (32%), Gaps = 18/299 (6%)

Query: 741  TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTE----P 796
            T +  S + +   P   ++K   Q   K    L  D   P    PP  +  +P +    P
Sbjct: 763  TTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIP 822

Query: 797  TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 856
             PAS++     P P+  S      V P ++KEE   A   +    + KP         T 
Sbjct: 823  RPASDSKIISHPGPSSES-KGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGS---PTP 878

Query: 857  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRAT-TAKSSGA---- 911
                P   +     ++ P   + +            A K +  + + T T K  G     
Sbjct: 879  PGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASI 938

Query: 912  -PQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRA 970
              Q S+  +T          G       +P PS    +  P  +     P   K +  + 
Sbjct: 939  FSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK 998

Query: 971  AAIPPIVTKVHEPPREDAAPT--KPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP 1027
                P   K+   P+ + APT  +      PPP        A  Q    P    +SP P
Sbjct: 999  ETKAPAAEKLE--PKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP 1055



 Score = 40.8 bits (94), Expect = 0.017
 Identities = 79/369 (21%), Positives = 131/369 (35%), Gaps = 56/369 (15%)

Query: 509  QQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKED---LLKEKTDDTSGEDNDEKEAVA 565
            +QP P +    K    KE     E++K  V +DK     ++K  TD  S      K  + 
Sbjct: 721  KQP-PEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIP 779

Query: 566  SKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKK 625
            S                      ++ +EE  TP    +  S + ++S   T E++     
Sbjct: 780  SS-------------------KVQSQAEEKTTPPLKTD--SAKPSQSFPPTGEKVSPFDS 818

Query: 626  GLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKK 685
              +    + S I    G  + S         K ++ +D + ++ + K  + + + +   K
Sbjct: 819  KAIPRPASDSKIISHPGPSSES---------KGQKQVDPVQKKEEPKKAQTKMSPKPDAK 869

Query: 686  APAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPA-TVNN 744
                 S     P     + +     S   +E          S  + P+ + + P  TV  
Sbjct: 870  PMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTG 929

Query: 745  S--SDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEA 802
                   SI S  +      GQ GP   +  GA          P +  PAP++P P S+ 
Sbjct: 930  KLFGFGASIFSQASNLISTAGQPGPHSQSGPGA----------PMKQAPAPSQP-PTSQG 978

Query: 803  TGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPV 862
                T   APP+P+   PV    +KE +  AA  +E   EQ P        +T K   P+
Sbjct: 979  PPKSTGQ-APPAPAKSIPV----KKETKAPAAEKLEPKAEQAPTVKR---TETEKKPPPI 1030

Query: 863  KSECTEEAE 871
            K   +  AE
Sbjct: 1031 KDSKSLTAE 1039



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 49/218 (22%), Positives = 84/218 (38%), Gaps = 29/218 (13%)

Query: 667  QQHKLKMEKER-NARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALH 725
            +Q + K+EK++ +A ++KK  P    EE    P  E+E++     S  ++ ++EE +   
Sbjct: 1194 KQEESKLEKDKASALQEKKPLP----EEKKLIP--EEEKIR----SEEKKPLLEEKKPTP 1243

Query: 726  ASGNEVPRGECSGPATVNNSSDTESIPSPHTE----AAKDTGQNGPKPPATLGADGPPPG 781
                 +P  + S P    +      +     +     A  T Q G +P   +       G
Sbjct: 1244 EDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKM------EG 1297

Query: 782  PPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGE 841
             P+  P+ +P   + T     T      P PP  + P  V P +EK E+          +
Sbjct: 1298 LPSGTPQSLPKEDDKT-----TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQ 1352

Query: 842  EQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD 879
            + K P       DTG + + + S   E     P   KD
Sbjct: 1353 QPKSPQG---LSDTGYSSDGISSSLGEIPSLIPTDEKD 1387



 Score = 38.9 bits (89), Expect = 0.065
 Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 40/245 (16%)

Query: 1396 PSRDLTEAYKTQALGPLKLKPAHEGLVATV-----------KEAGRSIHEIPREELR--- 1441
            P +DL++A + +   PL  +P   G  +             K A      +P E+ +   
Sbjct: 690  PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749

Query: 1442 --HTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHD-----VRSLIGSPGRTFPPV 1494
                P+ P   +P  +   +     K D  +S   S+  +     +++    P ++FPP 
Sbjct: 750  ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT 809

Query: 1495 HPLDVMADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHG 1554
                   D++A+ R   +  + S PG +S S G   +  PV   E  K  Q+ ++ +   
Sbjct: 810  GEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQ-KQVDPVQKKEEPKKAQTKMSPK--- 865

Query: 1555 APFAGHLPRGSP------------VTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKS 1602
             P A  +P+GSP            V T + +P+ QE S   S       +T  P+    +
Sbjct: 866  -PDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFS--LNLGSITDAPKSQPTT 922

Query: 1603 PHSTV 1607
            P  TV
Sbjct: 923  PQETV 927



 Score = 38.9 bits (89), Expect = 0.065
 Identities = 21/72 (29%), Positives = 28/72 (38%), Gaps = 6/72 (8%)

Query: 772  TLGADGPPPGPPTPPPEDIPAPTEPTPASEATGA------PTPPPAPPSPSAPPPVVPKE 825
            T G + P    P+  P     P +P P   ++        P PPP PP P  PPP  P  
Sbjct: 2366 TFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPP 2425

Query: 826  EKEEETAAAPPV 837
                 T+  P +
Sbjct: 2426 PLPPPTSPKPTI 2437



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 77/367 (20%), Positives = 115/367 (31%), Gaps = 55/367 (14%)

Query: 1946 PKEAPRVARPERPRA-------DTGHAFLAKPPARSGLEPASS--PSKGSEPRPLVPPVS 1996
            P EA  +++P  P+        D       KP     ++P +    S  +  +P +P   
Sbjct: 723  PPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK 782

Query: 1997 GHATIARTPAKNLAPHHASPDPPAPPASAS-DPHREKTQSKPFSIQELELRSLGYHGSSY 2055
              +         L    A P    PP      P   K   +P S  ++ +   G    S 
Sbjct: 783  VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKI-ISHPGPSSESK 841

Query: 2056 SPEGVEPVSPVSSPSLTHDKGLPK-HLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLR 2114
              + V+PV     P     K  PK   + + K        P  PGP    G+    P   
Sbjct: 842  GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGS------PTPPGPRPTAGQTVPTPQQS 895

Query: 2115 PLPESQ--------------PSSSPLL--QTAPGVKGHQRVVTLAQHISEVITQDYTRHH 2158
            P P+ Q              P S P    +T  G          +Q  + + T      H
Sbjct: 896  PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPH 955

Query: 2159 PQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE------GGKR 2212
             Q  S P  AP+   P  S P      P S    PP    APA+  P  +        K 
Sbjct: 956  SQ--SGP-GAPMKQAPAPSQPPTSQGPPKSTGQAPP----APAKSIPVKKETKAPAAEKL 1008

Query: 2213 SPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPS--------RM 2264
             P+  +   +   E   +P    +  +     + AV P       + E +         +
Sbjct: 1009 EPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNI 1068

Query: 2265 GSKSPGN 2271
            GSK P N
Sbjct: 1069 GSKDPPN 1075



 Score = 34.3 bits (77), Expect = 1.6
 Identities = 14/37 (37%), Positives = 30/37 (81%), Gaps = 3/37 (8%)

Query: 167  LSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEE 203
            +++ +++Q+   +DRE+ +VE++ +KL+KKQ +L+EE
Sbjct: 3757 MARAKILQD---IDRELDLVERESAKLRKKQAELDEE 3790


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score = 82.0 bits (201), Expect = 7e-15
 Identities = 142/557 (25%), Positives = 181/557 (32%), Gaps = 126/557 (22%)

Query: 743  NNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPP---------------- 786
            N     ++  +  T AA+  G   P+PP   G+  PPP P TP                 
Sbjct: 3    NKRDKAKAGAAARTPAARAPGLLTPRPP---GSPRPPP-PVTPAALRVLGAAGAVGRKPL 58

Query: 787  ------------PEDIP--APTEPTPASEATGAPTPPP------APPSPSAPPPVVPKEE 826
                        PE  P   PT     S    A  PP       APP+ +  P  V    
Sbjct: 59   AERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPG 118

Query: 827  KEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEAT 886
            +   T    P+  G++    +AEE  V  GKA E  K             G         
Sbjct: 119  RASGTTRPGPL--GQKGLRISAEE-TVARGKATEAPKRSALSAGARRDTSGPTPGTPSPA 175

Query: 887  AEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAE-----------GGDKN 935
                 +A   E G  R   +     P +    +  SA E    E           GG   
Sbjct: 176  MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ 235

Query: 936  R------------LLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEP 983
            R            L SP  S  +  G PRA A P +P    + K   A  PP VT    P
Sbjct: 236  RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP----KPKGLQALRPPQVT----P 287

Query: 984  PREDAAP----------TKPAPPA-----PPPPQNLQPESD------------APQQPGS 1016
            PR+DAAP            P+P A      PP     P S             AP  P S
Sbjct: 288  PRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP-S 346

Query: 1017 SPRGKSRSPAPPA--DKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFP-------VPPR 1067
            +P      P+PPA    +A   +  P   A    LP  PP      P P       +PP 
Sbjct: 347  APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP-SPPLSPLATPPPQAPPALALPPL 405

Query: 1068 EVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRP-PTISNP------PPLISSAK 1120
            +   + P +P  S  +   P  P  L +H    P  P P P +  P      PP+  SA 
Sbjct: 406  QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 465

Query: 1121 HPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLS 1180
             PS     + A        L VP S  A  P+ P     P    P    P    K    +
Sbjct: 466  PPSQAPPSLAA------PPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 519

Query: 1181 PRGQAGPP-ESLGVPTA 1196
            P   A PP ++L  P A
Sbjct: 520  PPALATPPLQALPSPPA 536



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 124/510 (24%), Positives = 166/510 (32%), Gaps = 83/510 (16%)

Query: 779  PPGPPTPPPEDIPAPTEPT---------PASEATGAPTPPPAPPSPSAPPPVVPKEEKEE 829
            PPG P PPP   PA              P +E  G       P S     P         
Sbjct: 29   PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88

Query: 830  ETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEE------------AEEGPAKG 877
              A+ PP     E+ PPA        G    P ++  T              AEE  A+G
Sbjct: 89   NPASRPPASGRGERAPPAKN---TSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 145

Query: 878  KDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSAT--------CSADEVDEA 929
            K   A EA    AL A  +   SG      S    + S ++ T         SA      
Sbjct: 146  K---ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT 202

Query: 930  EGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAA 989
            EG  K+   +   S   P+   R   S    L     +  +++  P+ +     P     
Sbjct: 203  EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT 262

Query: 990  PTKPAPPAPPPPQNLQ---------PESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFP 1040
            P  PA P+ P P+ LQ         P  DA    G        +P+P A  +++ P   P
Sbjct: 263  PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLP 322

Query: 1041 AFAAE-------AQKLPGDPPCWTS-----GLPFP--VPPREVIKA--SPHAPDPSAFSY 1084
            A           A  LP  PP  ++      LP P   PP +   +  SP      +F  
Sbjct: 323  ATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 382

Query: 1085 APPGHPL----PLGLHDTARPVLPRPPTISNPPPL----ISSAKHPSVLERQI--GAISQ 1134
            +PP  PL    P      A P L  PP+    PPL      S + P+ L   +     S 
Sbjct: 383  SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP 442

Query: 1135 GMSVQLHVPYSEHAKAPVGP------------VTMGLPLPMDPKKLAPFS-GVKQEQLSP 1181
              S  +  P+S  A  PV P                L +P  P    P S        +P
Sbjct: 443  PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 502

Query: 1182 RGQAGPPESLGVPTAQEASVLRGTALGSVP 1211
               A PP  L  P  Q    L    L ++P
Sbjct: 503  PPLAAPPLQLAKPPPQAPPALATPPLQALP 532



 Score = 68.9 bits (167), Expect = 6e-11
 Identities = 118/503 (23%), Positives = 177/503 (35%), Gaps = 81/503 (16%)

Query: 739  PATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 798
            PAT ++SS T  + +P   A          PP+      PP  PP+     + +PT    
Sbjct: 322  PATPHSSSLTCQLATPLPLAPPSPSA----PPSLQTLPSPPATPPSQATTSLGSPTLQAT 377

Query: 799  ASEATGAPTPPPAPPSPSAPPPV-VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 857
             S     P  P A P P APP + +P  +      A+PP+       P A   LAV   +
Sbjct: 378  HSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 437

Query: 858  A------EEPVKSECTEEAEE--GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSS 909
            A        PV++  +  A     P+    ++A  + A   L+       S  A+   S 
Sbjct: 438  APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP----SPPASPPMSP 493

Query: 910  GAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL--KQLK 967
             A     +    +A  +         +L  P P        P   A P  P     +   
Sbjct: 494  SATPPPQAPPPLAAPPL---------QLAKPPPQAPPALATPPLQALPSPPASFPGQAPF 544

Query: 968  QRAAAIP--PIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSP 1025
              +A++P  P+ T   + P   AAP    PP+PP    LQ    AP++P          P
Sbjct: 545  SPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ----APRRP----------P 590

Query: 1026 APPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYA 1085
             P  D     P    A A      PG PP          PP     ++   PD +  S +
Sbjct: 591  TPGPDTSVSGPRLTLALA------PGPPP----------PPSRSPSSTLSGPDLAGHSSS 634

Query: 1086 PPGHPLPLGLHDTARPVLPRPPTISNPPPLIS-SAKHPSVLERQIGAISQGMSVQLHVPY 1144
                P  L  +D+     P     ++PPP    +A HP+       A S+G +  L    
Sbjct: 635  ATSTPEELRGYDSG----PEGGAAASPPPDAELAACHPA-------AWSRGPAPPLAFRG 683

Query: 1145 SEHAKAPVGPVT-----MGLPLPMD---PKKLAPFSGVKQEQLSPRGQAGPPESLGVPTA 1196
            +  A  P  P T      GL    +   P+   P  G      SP G +G   + G    
Sbjct: 684  APGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP-GTSGGKAAAGAGAG 742

Query: 1197 QEASVLRGTALGSVPGGSITKGI 1219
              +   +   LG +P G++   +
Sbjct: 743  ASSRSPKQARLGELPLGALQASV 765



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 134/560 (23%), Positives = 172/560 (30%), Gaps = 94/560 (16%)

Query: 683  KKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATV 742
            K  +P   S             +   G+  + EE V   +A  A      R   S  A  
Sbjct: 107  KNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAP----KRSALSAGARR 162

Query: 743  NNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEA 802
            + S  T   PSP                    A G   G P P P   P P    P    
Sbjct: 163  DTSGPTPGTPSPAMARRSR-------------AAGTEVGLPRPAPSARPRPPTEGPRKSV 209

Query: 803  TGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPV 862
            + A       PSP+               A   P   G  Q+ PA+  L+        P 
Sbjct: 210  SSASEHSTTEPSPA---------------ARRRPSAGGGLQR-PASRSLSSSATPLSSPA 253

Query: 863  KSECTEEAEEGP-AKG---KDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSS 918
            +S        GP A+G     A  ++   +G       +    R   A + G P  S   
Sbjct: 254  RS--------GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPL 304

Query: 919  ATCSADEVDEAEGGDKNRLLSPRPSLLT---PTGDPRANASPQKPLDLKQLKQRAAAIP- 974
            AT S     +++        +P  S LT    T  P A  SP  P  L+ L    A  P 
Sbjct: 305  ATPSPSAALQSQ-APPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS 363

Query: 975  --------PIVTKVHE-PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSP 1025
                    P +   H   P    +P    PP  PP   L P    P  P S P     +P
Sbjct: 364  QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATP 423

Query: 1026 APPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYA 1085
            +P A           A A    + P  PP        P PP +    SP A  P + S  
Sbjct: 424  SPQAPN---------ALAVHLLQAPFSPP--------PSPPVQA-PFSPPASPPVSPSAT 465

Query: 1086 PPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYS 1145
            PP    P      A P L  PP+    PP+  SA  P      + A      +QL  P  
Sbjct: 466  PPSQAPP----SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA----PPLQLAKPPP 517

Query: 1146 EHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGT 1205
            +   A   P    LP P       P S   Q   SP     P   L  P  Q   VL   
Sbjct: 518  QAPPALATPPLQALPSP-------PASFPGQAPFSPSASL-PMSPLATPPPQAPPVLAAP 569

Query: 1206 ALGSVPGGSITKGIPSTRVP 1225
             L   P    +  + + R P
Sbjct: 570  LLQVPPSPPASPTLQAPRRP 589



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 172/729 (23%), Positives = 242/729 (33%), Gaps = 159/729 (21%)

Query: 1826 TTVEHAPIWRPGTEQSSGSSGSS------GGGGGSSSRPASHSHAHQHSPISPRTQDALQ 1879
            T  E AP  R G  +S+G+S  +        G G  + PA ++      P+S   + +  
Sbjct: 69   TIPESAP--RAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSP---GPVSSPGRASGT 123

Query: 1880 QRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPA--THCPLGGTLDGVYP 1937
             RP  L   G KG+  + E    TV R  +T +P R A +      T  P  GT      
Sbjct: 124  TRPGPL---GQKGLRISAEE---TVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 177

Query: 1938 TLMEP----VLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSK-----GSEP 1988
                     V LP+ AP  ARP RP  +     ++     S  EP+ +  +     G   
Sbjct: 178  RRSRAAGTEVGLPRPAPS-ARP-RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ 235

Query: 1989 RPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSL 2048
            RP    +S  AT   +PA++      +P  PA P+          Q KP  +Q L    +
Sbjct: 236  RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS----------QPKPKGLQALRPPQV 285

Query: 2049 GYHGSSYSPE-GVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEA 2107
                   +P  G    SP+++PS                + L+ +  P  P         
Sbjct: 286  TPPRKDAAPALGPLSSSPLATPS--------------PSAALQSQAPPTLPATPHSSSLT 331

Query: 2108 AHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLP 2167
              L    PL    PS+ P LQT P           +Q  + + +      H    S PL 
Sbjct: 332  CQLATPLPLAPPSPSAPPSLQTLPSPPA----TPPSQATTSLGSPTLQATHSFLPSPPL- 386

Query: 2168 APLYSFPGASCPVL---DLRRPPSDLYLPP------PDHGAPARGSPHSEGGKRSPEPNK 2218
            +PL + P  + P L    L+ PPS    PP      P   AP   + H      SP P+ 
Sbjct: 387  SPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 446

Query: 2219 TSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAF 2278
                        P SPP     P  S SA  P               S++P + + PP  
Sbjct: 447  PVQA--------PFSPP---ASPPVSPSATPP---------------SQAPPSLAAPPLQ 480

Query: 2279 FSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQA 2338
                  ++  M  S          T     P   ++ P  ++   P      L T   QA
Sbjct: 481  VPPSPPASPPMSPSA---------TPPPQAPP-PLAAPPLQLAKPPPQAPPALATPPLQA 530

Query: 2339 VQEHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSD 2398
            +                           SPP S     P + SASLP + P+     ++ 
Sbjct: 531  LP--------------------------SPPASFPGQAPFSPSASLPMS-PLATPPPQAP 563

Query: 2399 HTLTSPGGGGKAKVSGRP---SSRKAKSPAP-----------GLASGDRPPSVSSVHSEG 2444
              L +P           P   + R+  +P P            LA G  PP   S  S  
Sbjct: 564  PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS-- 621

Query: 2445 DCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHA 2504
                   L+        SSA STP          + G  ASPPP    A   P      A
Sbjct: 622  ------TLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPA-----A 670

Query: 2505 WDEEPKPLL 2513
            W   P P L
Sbjct: 671  WSRGPAPPL 679



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 136/579 (23%), Positives = 190/579 (32%), Gaps = 131/579 (22%)

Query: 1753 PTPGTPATAMDRLAYLPTA----PQPFSSRHSSSPLSPGGP----THLTKPTTTSSSERE 1804
            PTPGTP+ AM R +         P+P  S     P    GP    +  ++ +TT  S   
Sbjct: 167  PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE--GPRKSVSSASEHSTTEPSPAA 224

Query: 1805 RDRDR-----ERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1859
            R R       +R   R    S    ++     P  R GT ++          G  + RP 
Sbjct: 225  RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSAR-GTPRAPAHPSQPKPKGLQALRPP 283

Query: 1860 SHSHAHQHS-----PIS------PRTQDALQ-QRPSVLHNTGMKGIITAVEPSTPTVLRS 1907
              +   + +     P+S      P    ALQ Q P  L  T     +T  + +TP  L  
Sbjct: 284  QVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTC-QLATPLPLAP 342

Query: 1908 TSTSSPVR------PAATFPPATHCPLGG-TLDGVYPTLMEPVLLPKEAPRVARPERPRA 1960
             S S+P        P AT P      LG  TL   +  L  P L P   P    P+ P A
Sbjct: 343  PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP---PQAPPA 399

Query: 1961 DTGHAFLA--KPPARSGLEPASSPSKGSE--------------------PRPLVPPVSGH 1998
                   A   PPA   L P ++PS  +                       P  PP S  
Sbjct: 400  LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 459

Query: 1999 ATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS------------------- 2039
             + + TP     P  A+P    PP+  + P    + + P                     
Sbjct: 460  VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 519

Query: 2040 --------IQELELRSLGYHGSS-YSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKS--- 2087
                    +Q L      + G + +SP    P+SP+++P       L   L ++  S   
Sbjct: 520  PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA 579

Query: 2088 --HLEGELRPKQPGP-VKLGGEAAHLPHLRPLPESQPSSSP-LLQTAPGVKGHQRVVTLA 2143
               L+   RP  PGP   + G    L  L P P   PS SP    + P + GH    T  
Sbjct: 580  SPTLQAPRRPPTPGPDTSVSGPRLTLA-LAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 638

Query: 2144 QH--------------ISEVITQDYTRHHPQQLS--------------APLPAPLYSFPG 2175
                             S     +    HP   S              APLP P  + PG
Sbjct: 639  PEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 698

Query: 2176 AS---CPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGK 2211
            ++   C + +   P S    P      P   SP + GGK
Sbjct: 699  SADGLCTIYETEGPESATPAPGALDPGP---SPGTSGGK 734



 Score = 37.7 bits (86), Expect = 0.14
 Identities = 82/348 (23%), Positives = 114/348 (32%), Gaps = 69/348 (19%)

Query: 2174 PGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVS 2233
            P A  P L   RPP     PPP   A  R    +    R P   +   +GG    I   +
Sbjct: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGAT--IPESA 74

Query: 2234 PPEGMTEPGHSRS---AVYPLLYRDGEQTEPSRMGSKSP-------GNTSQPPAFFSK-- 2281
            P  G T    + S   A  P     GE+  P++  S  P         T++P     K  
Sbjct: 75   PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 134

Query: 2282 LTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQE 2341
               +   + + K  E  K+         + +   PGT     PA      M  RS+A   
Sbjct: 135  RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP---SPA------MARRSRA--- 182

Query: 2342 HASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHTL 2401
             A T +GL                   P  A +  P       P   P  +    S+H+ 
Sbjct: 183  -AGTEVGL-------------------PRPAPSARP-----RPPTEGPRKSVSSASEHST 217

Query: 2402 TSPGGGGKAKVSG-----RPSSRKAKSPAPGLASGDR-----------PPSVSSVHSEGD 2445
            T P    + + S      RP+SR   S A  L+S  R           P   S    +G 
Sbjct: 218  TEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL 277

Query: 2446 CNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPA 2493
               R P      +D   + G  P   +PL     +  + S  PP LPA
Sbjct: 278  QALRPPQVTPPRKDAAPALG--PLSSSPLATPSPSAALQSQAPPTLPA 323



 Score = 36.2 bits (82), Expect = 0.42
 Identities = 47/198 (23%), Positives = 67/198 (33%), Gaps = 9/198 (4%)

Query: 697 PPVVEDEEMEASG-VSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPH 755
           PPV       AS  VS +     +   +L A   +VP    + P    +++     P P 
Sbjct: 446 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPL 505

Query: 756 TEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIP--APTEPTPASEATGAPTPPPAPP 813
                   +  P+ P  L    PP      PP   P  AP  P+ +   +   TPPP  P
Sbjct: 506 AAPPLQLAKPPPQAPPALAT--PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 563

Query: 814 SPSAPPPV-VPKEEKEEETAAAP--PVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEA 870
              A P + VP       T  AP  P   G +    +   L +       P  S      
Sbjct: 564 PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS-VSGPRLTLALAPGPPPPPSRSPSST 622

Query: 871 EEGPAKGKDAEAAEATAE 888
             GP     + +A +T E
Sbjct: 623 LSGPDLAGHSSSATSTPE 640


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 82.0 bits (201), Expect = 7e-15
 Identities = 163/738 (22%), Positives = 261/738 (35%), Gaps = 112/738 (15%)

Query: 478  NYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPE 537
            +Y +    S R   + QQ   +++  Q+   +     +  EEK E +  +E    EEK  
Sbjct: 40   SYSAKAYESIRVSSELQQTWTKRKHGQEMTSKSLQTDTIVEEKKEVKLVEETVVPEEKSA 99

Query: 538  VENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAIT 597
               +    L E   D     N     +    +   + Q  R G  T  M N    E+ + 
Sbjct: 100  DVREAAIELPESVQDVEIPPNIPSVQL----KMDRSQQTSRTGYWT--MMNIPPVEK-VD 152

Query: 598  PQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIA-------------RMVGSK 644
             +Q    +  E+   SR  +     +K+  L+H  +    A               +G K
Sbjct: 153  KEQQTYFSESEIVVISR-PDSSSTKSKEDALKHKSSGKIFASEHPEFQPATNSNEEIGQK 211

Query: 645  TVSQCKNFYFNYKKRQNL---DEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVE 701
             +S+  +F    KK   +   DE+ ++  + + +E +A +K   A         FP  ++
Sbjct: 212  NISRT-SFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQ 270

Query: 702  DEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKD 761
               +E +          E    +  S  E P  E +  A   NS   +  P+      + 
Sbjct: 271  PPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAA-TAVAENSVKVQPPPAEEAPLVEF 329

Query: 762  TGQNGP-----KPPATLGADGPPPGPPT-----PPPEDIPAPTEPTPASEATG---APTP 808
              +  P      P   L A+  PP         PP E +P P E +P+ E  G   +P+ 
Sbjct: 330  PAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSA 389

Query: 809  PPAP---------------PSPSAPP----------PVVPKEEKEEE-------TAAAPP 836
              AP               P+   PP          P++P+E   EE       TA   P
Sbjct: 390  QKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETP 449

Query: 837  VEEG-EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEK 895
             EE   E + P  +E   +   AE  + +     A+E PA+ +   + E +AE A  AE 
Sbjct: 450  AEEAPTEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEA-HAEV 508

Query: 896  KEGGSGRATTAKSSG---------APQD-------SDSSATCSADE--VDEAEGGDKNRL 937
            +   +   T  ++S          AP D       S  S   SA+E   +      K   
Sbjct: 509  QSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVS 568

Query: 938  LSPRP-SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPP 996
            +   P  L  P+G+          + L    + +A   P   +V  PP E+A      PP
Sbjct: 569  IEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAP--AEVQPPPAEEAPAEVQPPP 626

Query: 997  APPPPQNLQP----ESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPG- 1051
            A   P  +QP    E+ A  QP  +    +    PPA+   E P       AE Q  P  
Sbjct: 627  AEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAE---EAP-------AEVQPPPAE 676

Query: 1052 DPPCWTSGLPFPVPPREVIKASPHAP---DPSAFSYAPPGHPLPLGLHDTARPVLPRPPT 1108
            + P     LP    P E   A+ H+P   D  A   +   H  P  L  T    +     
Sbjct: 677  EAPAEVQSLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEEFPIGEASA 736

Query: 1109 ISNPPPLISSAKHPSVLE 1126
              +PPP   + +  +++E
Sbjct: 737  EVSPPPSEQTPEDEALVE 754



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 70/344 (20%), Positives = 113/344 (32%), Gaps = 39/344 (11%)

Query: 509 QQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKG 568
           Q P+P+ +  E+   E +  A  E    E   +    L E+T        +E  A     
Sbjct: 458 QSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSA------EEAHAEVQSP 511

Query: 569 RKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLL 628
                +       I    A EA ++E  TP ++    S E +      E +  +AK   +
Sbjct: 512 LAEETTAEEASAEIQLLAAIEAPADE--TPAEAQSPLSEETSAEEAPAEVQSPSAKGVSI 569

Query: 629 EHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPA 688
           E       +    G +T ++  +                  +++      A  + +  PA
Sbjct: 570 EEAP--LELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPA 627

Query: 689 AASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDT 748
             +     PP  E+   E       E      AE       E P  E   P      ++ 
Sbjct: 628 EEAPAEVQPPPAEEAPAEVQPPPAEEAP----AEVQPPPAEEAP-AEVQPPPAEEAPAEV 682

Query: 749 ESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTP----------PPEDIPAPTEPTP 798
           +S+P+  T   +           TL A   PP    P          PP D+   TE  P
Sbjct: 683 QSLPAEETPIEE-----------TLAAVHSPPADDVPAEEASVDKHSPPADL-LLTEEFP 730

Query: 799 ASEATGAPTPPPAPPSPSAPPPV--VPKEEKEEETAAAPPVEEG 840
             EA+   +PPP+  +P     V  V  E +  + A  P V+ G
Sbjct: 731 IGEASAEVSPPPSEQTPEDEALVENVSTEFQSPQVAGIPAVKLG 774



 Score = 37.0 bits (84), Expect = 0.25
 Identities = 54/242 (22%), Positives = 82/242 (33%), Gaps = 30/242 (12%)

Query: 1792 LTKPTTTSSSERERD----RDRERDRDREREKSILTSTTTVE--HAPIWRPGTEQSSGSS 1845
            L K TT   +  E       +   D      +S L+  T+ E  HA +  P  E+++   
Sbjct: 461  LPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEE 520

Query: 1846 GSSGGGG-GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTV 1904
             S+      +   PA  + A   SP+S  T  + ++ P+ + +   KG+           
Sbjct: 521  ASAEIQLLAAIEAPADETPAEAQSPLSEET--SAEEAPAEVQSPSAKGV----------- 567

Query: 1905 LRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGH 1964
                  S    P    PP+               L       +EAP   +P  P A+   
Sbjct: 568  ------SIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQP--PPAEEAP 619

Query: 1965 AFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATI-ARTPAKNLAPHHASPDPPAPPA 2023
            A +  PPA         P     P  + PP +  A    + P    AP    P PPA  A
Sbjct: 620  AEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQP-PPAEEA 678

Query: 2024 SA 2025
             A
Sbjct: 679  PA 680


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 112/578 (19%), Positives = 242/578 (41%), Gaps = 65/578 (11%)

Query: 170 EELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQI 229
           EEL +  D +  E+        +LKKK  +L+E+               +    +S +Q+
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQEKLR-------------LAESEKSEIQL 208

Query: 230 IYDENRKKAEAAHRILEGLGPQVEL-----PLYNQPSDTRQYHENIKINQAMRKKLILYF 284
              E ++K E A  +L    PQV+       ++ Q  + R+  + I+  +    +     
Sbjct: 209 NVKELKRKLERAKFLL----PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERL 264

Query: 285 KRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRR----RAKESKVREYYEKQFPEI 340
           + +    ++ E+K  +R ++ +   EK++   E   R     R +E +++E  EK + + 
Sbjct: 265 REQEGKMREQEEKM-RRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323

Query: 341 RKQRELQERM---QSRVGQRGSGLSMSAAR---SEHEVSEIIDGLSEQENLEKQMRQLAV 394
            K RE +E+M   + R+ ++   +     +    E  + E  + L E+E   ++  ++  
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383

Query: 395 IPPMLYDAD--QQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFG 452
               + + +  ++R K +          +    +Q  NMW ++EKE  +++  +  +   
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 443

Query: 453 LIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPM 512
                 E++   E +       +++       +   R+ K ++Q+ Q  +Q+++ + Q  
Sbjct: 444 EQEKMQEQE---EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 500

Query: 513 PRSSQEEK----DEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKG 568
               QEE+    DE+ +EKE    E+K   + +++   ++KT +   +  D++E +  + 
Sbjct: 501 KMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE 560

Query: 569 RKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEE--METAKKG 626
           R     +  +K R    M  E   EE +  Q+      M   E   W +EE   E  +K 
Sbjct: 561 RM---REREKKMREEEEMMRE--QEEKMQEQEE----KMREQEEKMWEQEEKMQEQEEKM 611

Query: 627 LLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKA 686
             +  + W    +    K   Q +  +   +K Q  +E + + + KM ++    R++++ 
Sbjct: 612 WEQEEKMWE---QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK 668

Query: 687 PAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEAL 724
                E+     + E EE     + G EE+M E+ E +
Sbjct: 669 MQGQEEK-----MREQEEK----MQGQEEKMREQEEKM 697



 Score = 71.6 bits (174), Expect = 9e-12
 Identities = 99/533 (18%), Positives = 228/533 (42%), Gaps = 65/533 (12%)

Query: 166 RLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRS 225
           R  +E++ +  +R+  +   + +Q  K+++++++L E+  +  E EK +     + K R 
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE---QKKLRE 307

Query: 226 LVQIIYDENRKKAEAAHRILEGLGP--QVELPLYNQPSDTRQYHENIKINQAMR----KK 279
             + + ++  K  E   ++ E      + E  L+ Q    R+  + ++  +       ++
Sbjct: 308 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 367

Query: 280 LILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAK----------ESKV 329
           L    +R     K WEQ+   + ++ +   EKK+   E   R + +          E + 
Sbjct: 368 LREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 427

Query: 330 REYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQM 389
           +E+ +++ PE +++   QE+MQ +               E ++ E  + + +QE +  Q 
Sbjct: 428 KEWQQQRLPEQKEKLWEQEKMQEQ---------------EEKIWEQEEKIRDQEEMWGQE 472

Query: 390 RQLAVIPPMLYDADQ---QRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQ 446
           +++     M    DQ   Q  K  +    M D        Q   MW + E+   +E+ M+
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD--------QEERMWEQDERLREKEERMR 524

Query: 447 HPKNFGLIASFL--ERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQ----QQQQQQ 500
             K        +  E+KT  +    +   +K    + +  R  + R + +    Q+++ Q
Sbjct: 525 EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 584

Query: 501 QQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTD---DTSGED 557
           +Q+++ ++Q+      QEEK ++++EK  E+EE+    E ++ED ++E+ +   +   + 
Sbjct: 585 EQEEKMREQEE-KMWEQEEKMQEQEEKMWEQEEKM--WEQEEEDKMQEQEEMMWEQEEKM 641

Query: 558 NDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTE 617
            +++E +  +  K    + + + +  +    E    E     Q  E    E  E  R  E
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701

Query: 618 EEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHK 670
           E+M   ++      + W    +M G + + + +    + K++  + E L +H+
Sbjct: 702 EKMWGQEE------KMWGQEEKMWGQEEMREKEERIRDQKEK--MQERLPEHE 746



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 74/403 (18%), Positives = 162/403 (40%), Gaps = 54/403 (13%)

Query: 169 KEELIQNMDRV--DREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSL 226
           KEE ++  +++    E    E++I + +KK ++ EE   +  E  +       E + +  
Sbjct: 371 KEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 430

Query: 227 VQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKR 286
            Q    E ++K     ++ E      E  ++ Q    R   E         KK+    K 
Sbjct: 431 QQQRLPEQKEKLWEQEKMQEQ-----EEKIWEQEEKIRDQEEM----WGQEKKMWRQEKM 481

Query: 287 RNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYE--KQFPEIRKQR 344
           R    + WEQ+   R DQ  + W+++    E + R R KE ++RE  +  +Q  ++R+++
Sbjct: 482 REQEDQMWEQEEKMR-DQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540

Query: 345 ELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQ 404
           + QE+ +    Q          R E  + E    + E+E + ++  +            +
Sbjct: 541 KTQEQEKKTWDQE------EKMREEERMREREKKMREEEEMMREQEE---------KMQE 585

Query: 405 QRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVA 464
           Q  K       M +  +  ++++   MW ++EK   +E+  +  +   ++    E+    
Sbjct: 586 QEEKMREQEEKMWEQEEKMQEQEE-KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644

Query: 465 ECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQ--------------- 509
           E  ++    K  E  + +  +  + +G+ ++ ++Q+++ Q Q+++               
Sbjct: 645 EEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKM 704

Query: 510 ---------QPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKE 543
                    Q      QEE  EKE+    +KE+ +  +   +E
Sbjct: 705 WGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 47/249 (18%), Positives = 105/249 (42%), Gaps = 18/249 (7%)

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEK---EEEKPEVENDKEDLLKE 548
           + Q+++ ++Q+++  +Q++ +     + ++++EK +  EK   E+EK   E +KE   ++
Sbjct: 244 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQK 303

Query: 549 KTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASME 608
           K  +   +  +++E +  +  K    + +   +  R    E    E     +  E    E
Sbjct: 304 KLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 363

Query: 609 LNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQ 668
            +E  R  EE M        E  + W    +M   + + +        KK +  +E +++
Sbjct: 364 QDERLREKEERMR-------EQEKMWEQEEKMQEEERIRE------REKKMREEEETMRE 410

Query: 669 HKLKMEK-ERNARRKKKKAPAAASEEAAFPPVVEDEEM-EASGVSGNEEEMVEEAEALHA 726
            + KM+K E N   +++K             + E E+M E       +EE + + E +  
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470

Query: 727 SGNEVPRGE 735
              ++ R E
Sbjct: 471 QEKKMWRQE 479


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 150/644 (23%), Positives = 225/644 (34%), Gaps = 116/644 (18%)

Query: 546  LKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAEL 604
            +KE+ D  SG+ +       S+G  +    GR+K   +     +  N +   + + S   
Sbjct: 5    VKEEDDGLSGKHSMRTRR--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSA 62

Query: 605  ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664
            AS   N+S      + ET KK            A+ V  +  S  K+      KRQ    
Sbjct: 63   ASTSSNDS------KAETVKKS-----------AKKVKEEASSPLKS-----NKRQ---- 96

Query: 665  ILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEAL 724
               + K+  + E   R   KK     ++E + P    + E E+S           ++ ++
Sbjct: 97   ---REKVASDTEEADRTSSKKTK---TQEISRPNSPSEGEGESS-----------DSRSV 139

Query: 725  HASGNEVPRGECSGPATVNNSSDTESIPSPH-TEAAKDTGQNGP----KPPATLGADGPP 779
            +  G+  P+         +N S + SIPSP   E+  D+         +PPA     G  
Sbjct: 140  NDEGSSDPKD-----IDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVT 194

Query: 780  PGPPTPPPEDIPAPTE-PTPASEAT---GAPTPPPAPPSPSAPPPVVPKEEKEEETAAAP 835
            P P + PP     PT  PTP++ A    G+PT   AP  P AP   VP    ++  A  P
Sbjct: 195  PAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHP 254

Query: 836  --PVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKA 893
              P        P     L   TG A +P          + P  G+      +   G L  
Sbjct: 255  QRPPSPHPPPHPSPHPPLQPLTGSAGQP----SAPSHAQPPLHGQGPPGPHSLQAGPLLQ 310

Query: 894  E---------KKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSL 944
                        +   G+A    S  A     S    ++    +++   + + L P P  
Sbjct: 311  HPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLA 370

Query: 945  LTPTGDPRANASPQKPLDLKQLKQRAAAIP-PIVTKVHEPPREDAAP-----TKPAPPAP 998
            +     P     PQ P           + P P     + PP     P     T   P A 
Sbjct: 371  MPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAH 430

Query: 999  PPPQNLQPESDAPQQPGSSPRGKSRS---PAPPAD-------KEAEKPVFFPAFAAEAQK 1048
            PPP  L P+S       + P G ++S   P PPA        + A +P F     A+   
Sbjct: 431  PPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPF-----AQHPF 485

Query: 1049 LPGDPPCWTSGLPFPVPPREVIKASP--HAPDPSAFSYAPPGH-------PLPL------ 1093
            +PG PP  T   P   P      A P   A  P + + A  G        PLP       
Sbjct: 486  VPGGPPPIT---PPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEE 542

Query: 1094 GLHDTARPVLPRPP--TISNPPPLISSAKHPSVLERQIGAISQG 1135
             L D   P  P PP  + S  P ++ +  H S   R    + +G
Sbjct: 543  ALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRG 586



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%)

Query: 1802 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1861
            ERER++++E++R+RERE+                   E    +  SS    G  S P   
Sbjct: 627  EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 669

Query: 1862 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1920
               H      P         P +  +T    + T  E + P V+  T+ + P   P    
Sbjct: 670  GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 727

Query: 1921 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1977
             P  A H P    L  V PT+ E  L  +E   R  R    R      F  KPP    L 
Sbjct: 728  DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 784

Query: 1978 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2034
            PA++P +         +PP +G             PH  AS  P   P           Q
Sbjct: 785  PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 831

Query: 2035 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2094
             +P       L +   H    +    +P++ +   ++T     P H +    SH+   L 
Sbjct: 832  LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 883

Query: 2095 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2152
              Q  P+  G      P + PL     ++ P L   P   G      L Q  H  E++  
Sbjct: 884  LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 938

Query: 2153 D-YTRHHPQQLSAPLPAPL 2170
              +   +P+ L   +P P+
Sbjct: 939  PVFGTPYPRDLPGAIPPPM 957



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%)

Query: 1405 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1463
            K +A  PLK  K   E + +  +EA R+  +  + +    P  P       EG  +    
Sbjct: 83   KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 138

Query: 1464 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1522
            +  D G+S       D RS       T P +  P D  +D+   + +  ++ L+++P   
Sbjct: 139  VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 187

Query: 1523 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1576
             +  G       AP   P+L  P  +P        G+P A   P   P     P P    
Sbjct: 188  QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 246

Query: 1577 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1610
             Q  +L   +                + LT +  + +   H+  P H             
Sbjct: 247  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 306

Query: 1611 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1660
                HP P  P+    +   G     +    A+  TS+       A  +   PR      
Sbjct: 307  PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 366

Query: 1661 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1705
                  H+ P PT P         H +PP+L    P +             ++S   HH 
Sbjct: 367  APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 425

Query: 1706 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1765
              +A      ++    P  SS      A P G   L+Q  +LP   PP    P T + ++
Sbjct: 426  PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 474

Query: 1766 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1825
            A     PQP  ++H   P  PGGP  +T PT  S+S                        
Sbjct: 475  A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 502

Query: 1826 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1869
                  P   PGT      SG++  GG   G SS P             A    +    P
Sbjct: 503  -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 557

Query: 1870 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1929
             SP  +  +   PS  H +        ++    +  R+     P+              G
Sbjct: 558  RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 602

Query: 1930 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1974
              L       +E     +EA + AR ER R                +   A  A   A  
Sbjct: 603  SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 660

Query: 1975 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2019
            G      L          EP P     VPP  G  T A RT ++   PH  SP     P 
Sbjct: 661  GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 720

Query: 2020 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2060
              P + +DP                  RE  + + +   I+E ELR     G    P  +
Sbjct: 721  YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 780

Query: 2061 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2101
            +P+ P ++P        +LT       H        L  L++  L     +LRP+   P 
Sbjct: 781  DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 840

Query: 2102 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2159
            +L  E  H   +  L     +   +    P    H  + + L  H  + + Q      HP
Sbjct: 841  RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 900

Query: 2160 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2189
                L+A      + +P  + P   L +PP +
Sbjct: 901  LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 932



 Score = 39.7 bits (91), Expect = 0.038
 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%)

Query: 1969 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2028
            K  A+   E ASSP K S  R      S      RT +K       S      P S S+ 
Sbjct: 76   KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 129

Query: 2029 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2088
              E + S          RS+   GSS  P+ ++  +  +SPS+      P+  E    S 
Sbjct: 130  EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 174

Query: 2089 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2148
             + ++   QP  ++          + P P S P  +P L T         V         
Sbjct: 175  AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 225

Query: 2149 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2208
              T     + PQ  +AP+P           P L  +RPPS    P P    P +    S 
Sbjct: 226  --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 279

Query: 2209 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2268
            G   +P   +  + G G  G   +     +  PG  +    P     G+    +   +  
Sbjct: 280  GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 339

Query: 2269 PGNTSQPPAFFSKL 2282
            P  + Q PA  S L
Sbjct: 340  PHTSLQLPASQSAL 353



 Score = 32.0 bits (71), Expect = 7.9
 Identities = 12/45 (26%), Positives = 28/45 (62%)

Query: 491 GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535
           G    +++++  ++ +++ +   R  +E + EKEKE+E E+E E+
Sbjct: 602 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 646


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
            sapiens]
          Length = 1188

 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 100/378 (26%), Positives = 136/378 (35%), Gaps = 78/378 (20%)

Query: 778  PPPGPPTPPPEDIPAPT--EPTPASEATGAPTPP-----PAPPSPSAPPPVVPKEEKEEE 830
            PPPGP   PP+DI  P    P P+  +T  P PP     P PPS + PPP V +      
Sbjct: 142  PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPH 201

Query: 831  TAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGA 890
            T ++P +    +  PPA             P  +         PA    A A+  T    
Sbjct: 202  TLSSPSIPTPPDFIPPA-------------PPLAFLAPPPPPVPAPAPPAPASPHTVGTR 248

Query: 891  LKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGD 950
            L         G  T  KS  A     + AT ++     AE        +P P L  P   
Sbjct: 249  LFP------PGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRS- 301

Query: 951  PRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQ----- 1005
                  P  P+       R ++IP  V +  E PR++   TK AP   P P +       
Sbjct: 302  --FKVPPPTPV-------RTSSIP--VQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350

Query: 1006 -------PESDAPQQ-----PGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDP 1053
                   PE D P +     P S   G+S+S    AD+ A  P   P     A  LP   
Sbjct: 351  QVYPDRAPEPDCPGELKATAPASPRLGQSQS---QADERAGTPPPAPPLPPPAPPLPPPA 407

Query: 1054 PCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPP 1113
            P     LP   PP    + + H   P+ F+  P           ++ P L   P   +P 
Sbjct: 408  P----PLPPAAPPLPCAQKAAH--PPAGFTKTP----------KSSSPALKPKPNPPSPE 451

Query: 1114 PLISSA----KHPSVLER 1127
               SSA    + PS +E+
Sbjct: 452  NTASSAPVDWRDPSQMEK 469



 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 97/342 (28%), Positives = 129/342 (37%), Gaps = 55/342 (16%)

Query: 732  PRGECSGPAT-VNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI 790
            P G   GP   ++       +PSP + A        P PP  L    PPP    PPP  +
Sbjct: 143  PPGPAPGPPQDISEPPGGSPLPSPPSTA--------PPPPPLLLEPPPPPSMAPPPPPVL 194

Query: 791  PAPTEPTPASEATGAPTP----PPAPPSP--SAPPPVVPKEEKEEETAAAPPVEEGEEQK 844
             A + P   S +   PTP    PPAPP    + PPP VP        A A P   G    
Sbjct: 195  EALSPPHTLS-SPSIPTPPDFIPPAPPLAFLAPPPPPVP---APAPPAPASPHTVGTRLF 250

Query: 845  PPAA-----EELAVDTGKAEEPVKSECTEEAE-EGPAKGKDAEAAEATAEGALKAEKKEG 898
            PP        ++A++  +AE    S     AE +G A G + E    T   + K      
Sbjct: 251  PPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPE-PHLTFPRSFKVPP--- 306

Query: 899  GSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDK---NRLLSPRPSLLTPTGDPRANA 955
                 T  ++S  P      A        + EG  K   +RL  P    + P      + 
Sbjct: 307  ----PTPVRTSSIPVQEAQEAP------RKEEGATKKAPSRLPLPPSFHIRPASQVYPDR 356

Query: 956  SPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPG 1015
            +P+ P    +LK  A A P +  +      E A    PAPP PPP   L P   AP  P 
Sbjct: 357  APE-PDCPGELKATAPASPRL-GQSQSQADERAGTPPPAPPLPPPAPPLPP--PAPPLPP 412

Query: 1016 SSPRGKSRSPAPPADKEAEKPVFF---PAFAAEAQKLPGDPP 1054
            ++P      P P A K A  P  F   P  ++ A K   +PP
Sbjct: 413  AAP------PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPP 448



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 93/382 (24%), Positives = 139/382 (36%), Gaps = 36/382 (9%)

Query: 727  SGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNG-PKPPATLGADGPPPGPPT- 784
            SG   P    SGPA  + ++   +  S    A KD+G  G P+ PA+     P       
Sbjct: 677  SGPTTPLKATSGPAIASTATTLPTTTS-QLMAEKDSGPAGQPEKPASQEVSTPSQARGEG 735

Query: 785  PPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAA-PPVEEGEEQ 843
             P E    PT+   +S A    T P     P    P   +     E A   P +  G   
Sbjct: 736  SPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAA 795

Query: 844  KPPAAEELAVDTG-KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEG-ALKAEKKEGGSG 901
             P    E+    G  A+ P  ++ T+E    P  G+  E     A   A +   ++G S 
Sbjct: 796  GPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSV 855

Query: 902  RATTAKSS--GAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQK 959
             A   +SS  G+ +D    A  S+D +  ++G   +  + P+         P     P K
Sbjct: 856  GAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNK 915

Query: 960  --PLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSS 1017
              P    +L + A      +++ H         TKP P AP   + + P S+ P Q    
Sbjct: 916  WGP----RLGRDAEGTE--LSRRHNW-------TKPEPQAPVAWERVAP-SNLP-QGHPL 960

Query: 1018 PRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPF----PVPP------- 1066
            P+  S  P+P   +E E+  F         +   DP      L +      PP       
Sbjct: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020

Query: 1067 REVIKASPHAPDPSAFSYAPPG 1088
            R++  A P AP    FS  P G
Sbjct: 1021 RQLPNAGPGAPPALGFSRFPAG 1042



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 138/591 (23%), Positives = 196/591 (33%), Gaps = 98/591 (16%)

Query: 729  NEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPE 788
            +  P  +C G       +    +    ++A +  G   P PP    A   PP PP  PP 
Sbjct: 355  DRAPEPDCPGELKATAPASPR-LGQSQSQADERAGTPPPAPPLPPPA---PPLPPPAPP- 409

Query: 789  DIPAPTEPTPASEATGAP----TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVE-EGEEQ 843
             +P    P P ++    P    T  P   SP+  P   P     E TA++ PV+     Q
Sbjct: 410  -LPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPK--PNPPSPENTASSAPVDWRDPSQ 466

Query: 844  KPPAAEELAVD-TGKAEE---------PVKSECTEEAEEGPAKGKDAEAAEATAEGALKA 893
                  ELA    G   E         P  +  ++E ++GP   +        A+     
Sbjct: 467  MEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG 526

Query: 894  --EKKEGGSGRATTAKSSG--------APQDSDSSAT--------CSADEVDEAEGGDKN 935
              EK  GGS    T  +           PQDS + +                E E     
Sbjct: 527  VPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSI 586

Query: 936  RLLSPRPSL----LTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPT 991
              L P+P L    +   G      S  KP+  K L  ++  + P  +   +     A P 
Sbjct: 587  GSLPPKPRLEGGRICENGADDDKLS--KPV-AKNLPPQSTTLLPTTSLQPKAMLGPAIPP 643

Query: 992  KPAP-PAPPPPQNLQPESDAPQQPG-SSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKL 1049
            K  P PA PP   L P +      G ++P   +  P  P      K    PA A+ A  L
Sbjct: 644  KATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPL-----KATSGPAIASTATTL 698

Query: 1050 P-------GDPPCWTSGLPFPVPPREVIKASPHAPD--PSAFSYAPPGHPLPLGLHDTAR 1100
            P        +     +G P     +EV   S    +  PS  +  P       G   +A 
Sbjct: 699  PTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLP-----TQGARSSAA 753

Query: 1101 PVLPRPPTISNPPPLISSAKHPSVLERQI----------GAISQGMSVQLHVPYSEHAKA 1150
                  P     P L     H S L R++          GA   G  V++  P    AK 
Sbjct: 754  FPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKP 813

Query: 1151 PVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSV 1210
            P          P D     P +G   E+       G P +L +   Q A   +G ++G+ 
Sbjct: 814  PAS------AQPTDELLRHPVTGEVVER-------GSPMALLLAARQRAQ--KGRSVGAA 858

Query: 1211 PGGSITKGIPSTRVPSDSAITYRGSITH--GTPADVLYKGTITRIIGEDSP 1259
             G S   G  S R  S  A     SI H  GTP        + +   +DSP
Sbjct: 859  LGRSSLPG--SLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSP 907



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 66/267 (24%), Positives = 83/267 (31%), Gaps = 26/267 (9%)

Query: 937  LLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPP 996
            LL P P      G P+  + P     L      A   PP++ +   PP   A P  P   
Sbjct: 137  LLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE-PPPPPSMAPPPPPVLE 195

Query: 997  APPPPQNL-QPESDAPQQ--PGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDP 1053
            A  PP  L  P    P    P + P      P PP    A      P         PG  
Sbjct: 196  ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGV 255

Query: 1054 PCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPP 1113
              W S +       E  +ASP            P  P    L     P L  P +   PP
Sbjct: 256  TKWKSDVALNGRQAEATRASPP---------RSPAEPKGSALGPNPEPHLTFPRSFKVPP 306

Query: 1114 PLISSAKHPSVLE------RQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKK 1167
            P         V E      ++ GA  +  S +L +P S H +          P P  P +
Sbjct: 307  PTPVRTSSIPVQEAQEAPRKEEGATKKAPS-RLPLPPSFHIRPASQVYPDRAPEPDCPGE 365

Query: 1168 L------APFSGVKQEQLSPRGQAGPP 1188
            L      +P  G  Q Q   R    PP
Sbjct: 366  LKATAPASPRLGQSQSQADERAGTPPP 392



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 129/575 (22%), Positives = 192/575 (33%), Gaps = 138/575 (24%)

Query: 1049 LPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPT 1108
            +P  PP      P P PP+++ +    +P PS  S APP  PL L       P  P PP+
Sbjct: 139  IPPPPPG-----PAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLL------EP--PPPPS 185

Query: 1109 ISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLP-LPMDPKK 1167
            ++ PPP +  A  P                               P T+  P +P  P  
Sbjct: 186  MAPPPPPVLEALSP-------------------------------PHTLSSPSIPTPPDF 214

Query: 1168 LAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSD 1227
            + P        L+      PP     P A  +    GT L   P G +TK        SD
Sbjct: 215  IPP-----APPLAFLAPPPPPVPAPAPPAPASPHTVGTRL--FPPGGVTKW------KSD 261

Query: 1228 SAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSY 1287
             A+  R                      +   +R    R  + PKG  +    + H L++
Sbjct: 262  VALNGR----------------------QAEATRASPPRSPAEPKGSALGPNPEPH-LTF 298

Query: 1288 EGGMSVTQCSKEDGRSSSGPPHETA-APKRTYDMMEGRVGRAISSASIEGLMGRAIPPER 1346
                 V   +    R+SS P  E   AP++     +    R     S        + P+R
Sbjct: 299  PRSFKVPPPTPV--RTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDR 356

Query: 1347 HSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPP-----------PP 1395
                    +       +  + +S  +A E           R GTPPP           PP
Sbjct: 357  APEPDCPGELKATAPASPRLGQSQSQADE-----------RAGTPPPAPPLPPPAPPLPP 405

Query: 1396 PSRDLTEAYKTQALGPLKLKPAH--EGLVATVKEAGRSIHEIPREELRHTPELPLAPRPL 1453
            P+  L  A       P   K AH   G   T K +  ++   P      +PE   +  P+
Sbjct: 406  PAPPLPPAAPPL---PCAQKAAHPPAGFTKTPKSSSPALKPKPNPP---SPENTASSAPV 459

Query: 1454 KEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEE 1513
                 +Q   L+ +  A   GS++ D R L   PG T  P        + +   R   +E
Sbjct: 460  DWRDPSQMEKLRNELAAYLCGSRRED-RFLSHRPGPTVAP-----QSKEGKKGPRLPEKE 513

Query: 1514 SLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPT 1573
            +L S P          A+  P  VPE  K        E   AP +  LP    +    PT
Sbjct: 514  TLLSLP----------AKDTPPGVPE--KSLGGSSLTETEAAP-SLTLPSVDYIPQDSPT 560

Query: 1574 PRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVP 1608
            P     S+   +   + +L+S   + AK    ++P
Sbjct: 561  P-----SVRQIRNELEARLSSAAEKEAKPSIGSLP 590



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 72/291 (24%), Positives = 100/291 (34%), Gaps = 49/291 (16%)

Query: 1968 AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIA-------------RTPAKNLAPHHA 2014
            A PP    LEP   PS    P P++  +S   T++               P   LAP   
Sbjct: 170  APPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPP 229

Query: 2015 SPDPPAPPASASDPHREKTQSKP------------FSIQELELRSLGYHGSSYSPEGVEP 2062
                PAPPA AS PH   T+  P             + ++ E        S   P+G   
Sbjct: 230  PVPAPAPPAPAS-PHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG-SA 287

Query: 2063 VSPVSSPSLTHDKGL----PKHLEELDKSHLEGELRP-KQPGPVKLGGEAAHLP---HLR 2114
            + P   P LT  +      P  +        E +  P K+ G  K       LP   H+R
Sbjct: 288  LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR 347

Query: 2115 PLPESQPSSSPLLQTAPGVKGHQRVVTLAQ-HISEVITQDYTRHHPQQLSAPLPAPLYSF 2173
            P  +  P  +P     P   G  +    A   + +  +Q   R      + PLP P    
Sbjct: 348  PASQVYPDRAP----EPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPL 403

Query: 2174 PGASCPVLDLRRPPSDLYLPPPDHGA-PARG---SPHSEGGKRSPEPNKTS 2220
            P  + P+     PP+   LP     A P  G   +P S      P+PN  S
Sbjct: 404  PPPAPPL-----PPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPS 449



 Score = 35.8 bits (81), Expect = 0.55
 Identities = 70/306 (22%), Positives = 100/306 (32%), Gaps = 54/306 (17%)

Query: 2159 PQQLSAP-LPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPN 2217
            P  LS+P +P P    P A  P+  L  PP  +  P P    PA  SPH+ G +  P   
Sbjct: 200  PHTLSSPSIPTPPDFIPPAP-PLAFLAPPPPPVPAPAP----PAPASPHTVGTRLFPPGG 254

Query: 2218 KTS-----VLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNT 2272
             T       L G +      SPP    EP  S           G   EP     +S    
Sbjct: 255  VTKWKSDVALNGRQAEATRASPPRSPAEPKGSAL---------GPNPEPHLTFPRSFKVP 305

Query: 2273 SQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLM 2332
               P   S +    +     K++   KK  +     P ++I +P +++            
Sbjct: 306  PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI-RPASQV------------ 352

Query: 2333 TYRSQAVQEHASTNMGLEAIIRKALMGKYDQWEE-------SPPLSANAFNPLNASASLP 2385
             Y  +A +      +   A     L     Q +E       +PPL   A      +  LP
Sbjct: 353  -YPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLP 411

Query: 2386 AAMPITAADGRSDHTLTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGD 2445
             A P      ++ H    P G  K            KS +P L     PPS  +  S   
Sbjct: 412  PAAPPLPCAQKAAHP---PAGFTKTP----------KSSSPALKPKPNPPSPENTASSAP 458

Query: 2446 CNRRTP 2451
             + R P
Sbjct: 459  VDWRDP 464



 Score = 35.0 bits (79), Expect = 0.94
 Identities = 64/248 (25%), Positives = 83/248 (33%), Gaps = 35/248 (14%)

Query: 1897 VEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPE 1956
            V P TP      ++S PV+ A   P       G T        + P    + A +V    
Sbjct: 304  VPPPTPV----RTSSIPVQEAQEAPRKEE---GATKKAPSRLPLPPSFHIRPASQVYPDR 356

Query: 1957 RPRADTGHAFLAKPPA--RSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHA 2014
             P  D      A  PA  R G   + +  +   P P  PP+         PA  L P   
Sbjct: 357  APEPDCPGELKATAPASPRLGQSQSQADERAGTPPP-APPLP-------PPAPPLPP--- 405

Query: 2015 SPDPPAPPASASDPHREKTQSKPFSIQELELRS---LGYHGSSYSPEGVEPVSPVSSPSL 2071
             P PP PPA+   P  +K    P    +    S   L    +  SPE     +PV     
Sbjct: 406  -PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464

Query: 2072 THDKGLPKHLEE-LDKSHLEGELRPKQPGPV-----KLGGEAAHLPHLRPLPESQPSSSP 2125
            +  + L   L   L  S  E      +PGP      K G +   LP    L      S P
Sbjct: 465  SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETL-----LSLP 519

Query: 2126 LLQTAPGV 2133
               T PGV
Sbjct: 520  AKDTPPGV 527



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 40/135 (29%), Positives = 52/135 (38%), Gaps = 17/135 (12%)

Query: 784  TPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEET----AAAPPVEE 839
            T P    P   E    S     P   P P S S+PP    K E+EEE        PP E 
Sbjct: 936  TKPEPQAPVAWERVAPSNL---PQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEF 992

Query: 840  GEEQKPPAAEELAVDTGKAEEPVKSECTE-----EAEEG--PAKGKDAEAAEATAEGALK 892
              + +PPA     +  G+   P ++  ++      A  G  PA G     A A   GA  
Sbjct: 993  SNDPEPPAPALQYL--GRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGG 1050

Query: 893  AEKKEGGSGRATTAK 907
             E+  GG GR+   K
Sbjct: 1051 LERFSGG-GRSLIKK 1064


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
            sapiens]
          Length = 1188

 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 100/378 (26%), Positives = 136/378 (35%), Gaps = 78/378 (20%)

Query: 778  PPPGPPTPPPEDIPAPT--EPTPASEATGAPTPP-----PAPPSPSAPPPVVPKEEKEEE 830
            PPPGP   PP+DI  P    P P+  +T  P PP     P PPS + PPP V +      
Sbjct: 142  PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPH 201

Query: 831  TAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGA 890
            T ++P +    +  PPA             P  +         PA    A A+  T    
Sbjct: 202  TLSSPSIPTPPDFIPPA-------------PPLAFLAPPPPPVPAPAPPAPASPHTVGTR 248

Query: 891  LKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGD 950
            L         G  T  KS  A     + AT ++     AE        +P P L  P   
Sbjct: 249  LFP------PGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRS- 301

Query: 951  PRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQ----- 1005
                  P  P+       R ++IP  V +  E PR++   TK AP   P P +       
Sbjct: 302  --FKVPPPTPV-------RTSSIP--VQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350

Query: 1006 -------PESDAPQQ-----PGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDP 1053
                   PE D P +     P S   G+S+S    AD+ A  P   P     A  LP   
Sbjct: 351  QVYPDRAPEPDCPGELKATAPASPRLGQSQS---QADERAGTPPPAPPLPPPAPPLPPPA 407

Query: 1054 PCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPP 1113
            P     LP   PP    + + H   P+ F+  P           ++ P L   P   +P 
Sbjct: 408  P----PLPPAAPPLPCAQKAAH--PPAGFTKTP----------KSSSPALKPKPNPPSPE 451

Query: 1114 PLISSA----KHPSVLER 1127
               SSA    + PS +E+
Sbjct: 452  NTASSAPVDWRDPSQMEK 469



 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 97/342 (28%), Positives = 129/342 (37%), Gaps = 55/342 (16%)

Query: 732  PRGECSGPAT-VNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI 790
            P G   GP   ++       +PSP + A        P PP  L    PPP    PPP  +
Sbjct: 143  PPGPAPGPPQDISEPPGGSPLPSPPSTA--------PPPPPLLLEPPPPPSMAPPPPPVL 194

Query: 791  PAPTEPTPASEATGAPTP----PPAPPSP--SAPPPVVPKEEKEEETAAAPPVEEGEEQK 844
             A + P   S +   PTP    PPAPP    + PPP VP        A A P   G    
Sbjct: 195  EALSPPHTLS-SPSIPTPPDFIPPAPPLAFLAPPPPPVP---APAPPAPASPHTVGTRLF 250

Query: 845  PPAA-----EELAVDTGKAEEPVKSECTEEAE-EGPAKGKDAEAAEATAEGALKAEKKEG 898
            PP        ++A++  +AE    S     AE +G A G + E    T   + K      
Sbjct: 251  PPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPE-PHLTFPRSFKVPP--- 306

Query: 899  GSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDK---NRLLSPRPSLLTPTGDPRANA 955
                 T  ++S  P      A        + EG  K   +RL  P    + P      + 
Sbjct: 307  ----PTPVRTSSIPVQEAQEAP------RKEEGATKKAPSRLPLPPSFHIRPASQVYPDR 356

Query: 956  SPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPG 1015
            +P+ P    +LK  A A P +  +      E A    PAPP PPP   L P   AP  P 
Sbjct: 357  APE-PDCPGELKATAPASPRL-GQSQSQADERAGTPPPAPPLPPPAPPLPP--PAPPLPP 412

Query: 1016 SSPRGKSRSPAPPADKEAEKPVFF---PAFAAEAQKLPGDPP 1054
            ++P      P P A K A  P  F   P  ++ A K   +PP
Sbjct: 413  AAP------PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPP 448



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 93/382 (24%), Positives = 139/382 (36%), Gaps = 36/382 (9%)

Query: 727  SGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNG-PKPPATLGADGPPPGPPT- 784
            SG   P    SGPA  + ++   +  S    A KD+G  G P+ PA+     P       
Sbjct: 677  SGPTTPLKATSGPAIASTATTLPTTTS-QLMAEKDSGPAGQPEKPASQEVSTPSQARGEG 735

Query: 785  PPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAA-PPVEEGEEQ 843
             P E    PT+   +S A    T P     P    P   +     E A   P +  G   
Sbjct: 736  SPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAA 795

Query: 844  KPPAAEELAVDTG-KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEG-ALKAEKKEGGSG 901
             P    E+    G  A+ P  ++ T+E    P  G+  E     A   A +   ++G S 
Sbjct: 796  GPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSV 855

Query: 902  RATTAKSS--GAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQK 959
             A   +SS  G+ +D    A  S+D +  ++G   +  + P+         P     P K
Sbjct: 856  GAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNK 915

Query: 960  --PLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSS 1017
              P    +L + A      +++ H         TKP P AP   + + P S+ P Q    
Sbjct: 916  WGP----RLGRDAEGTE--LSRRHNW-------TKPEPQAPVAWERVAP-SNLP-QGHPL 960

Query: 1018 PRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPF----PVPP------- 1066
            P+  S  P+P   +E E+  F         +   DP      L +      PP       
Sbjct: 961  PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020

Query: 1067 REVIKASPHAPDPSAFSYAPPG 1088
            R++  A P AP    FS  P G
Sbjct: 1021 RQLPNAGPGAPPALGFSRFPAG 1042



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 138/591 (23%), Positives = 196/591 (33%), Gaps = 98/591 (16%)

Query: 729  NEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPE 788
            +  P  +C G       +    +    ++A +  G   P PP    A   PP PP  PP 
Sbjct: 355  DRAPEPDCPGELKATAPASPR-LGQSQSQADERAGTPPPAPPLPPPA---PPLPPPAPP- 409

Query: 789  DIPAPTEPTPASEATGAP----TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVE-EGEEQ 843
             +P    P P ++    P    T  P   SP+  P   P     E TA++ PV+     Q
Sbjct: 410  -LPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPK--PNPPSPENTASSAPVDWRDPSQ 466

Query: 844  KPPAAEELAVD-TGKAEE---------PVKSECTEEAEEGPAKGKDAEAAEATAEGALKA 893
                  ELA    G   E         P  +  ++E ++GP   +        A+     
Sbjct: 467  MEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG 526

Query: 894  --EKKEGGSGRATTAKSSG--------APQDSDSSAT--------CSADEVDEAEGGDKN 935
              EK  GGS    T  +           PQDS + +                E E     
Sbjct: 527  VPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSI 586

Query: 936  RLLSPRPSL----LTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPT 991
              L P+P L    +   G      S  KP+  K L  ++  + P  +   +     A P 
Sbjct: 587  GSLPPKPRLEGGRICENGADDDKLS--KPV-AKNLPPQSTTLLPTTSLQPKAMLGPAIPP 643

Query: 992  KPAP-PAPPPPQNLQPESDAPQQPG-SSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKL 1049
            K  P PA PP   L P +      G ++P   +  P  P      K    PA A+ A  L
Sbjct: 644  KATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPL-----KATSGPAIASTATTL 698

Query: 1050 P-------GDPPCWTSGLPFPVPPREVIKASPHAPD--PSAFSYAPPGHPLPLGLHDTAR 1100
            P        +     +G P     +EV   S    +  PS  +  P       G   +A 
Sbjct: 699  PTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLP-----TQGARSSAA 753

Query: 1101 PVLPRPPTISNPPPLISSAKHPSVLERQI----------GAISQGMSVQLHVPYSEHAKA 1150
                  P     P L     H S L R++          GA   G  V++  P    AK 
Sbjct: 754  FPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKP 813

Query: 1151 PVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSV 1210
            P          P D     P +G   E+       G P +L +   Q A   +G ++G+ 
Sbjct: 814  PAS------AQPTDELLRHPVTGEVVER-------GSPMALLLAARQRAQ--KGRSVGAA 858

Query: 1211 PGGSITKGIPSTRVPSDSAITYRGSITH--GTPADVLYKGTITRIIGEDSP 1259
             G S   G  S R  S  A     SI H  GTP        + +   +DSP
Sbjct: 859  LGRSSLPG--SLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSP 907



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 66/267 (24%), Positives = 83/267 (31%), Gaps = 26/267 (9%)

Query: 937  LLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPP 996
            LL P P      G P+  + P     L      A   PP++ +   PP   A P  P   
Sbjct: 137  LLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE-PPPPPSMAPPPPPVLE 195

Query: 997  APPPPQNL-QPESDAPQQ--PGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDP 1053
            A  PP  L  P    P    P + P      P PP    A      P         PG  
Sbjct: 196  ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGV 255

Query: 1054 PCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPP 1113
              W S +       E  +ASP            P  P    L     P L  P +   PP
Sbjct: 256  TKWKSDVALNGRQAEATRASPP---------RSPAEPKGSALGPNPEPHLTFPRSFKVPP 306

Query: 1114 PLISSAKHPSVLE------RQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKK 1167
            P         V E      ++ GA  +  S +L +P S H +          P P  P +
Sbjct: 307  PTPVRTSSIPVQEAQEAPRKEEGATKKAPS-RLPLPPSFHIRPASQVYPDRAPEPDCPGE 365

Query: 1168 L------APFSGVKQEQLSPRGQAGPP 1188
            L      +P  G  Q Q   R    PP
Sbjct: 366  LKATAPASPRLGQSQSQADERAGTPPP 392



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 129/575 (22%), Positives = 192/575 (33%), Gaps = 138/575 (24%)

Query: 1049 LPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPT 1108
            +P  PP      P P PP+++ +    +P PS  S APP  PL L       P  P PP+
Sbjct: 139  IPPPPPG-----PAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLL------EP--PPPPS 185

Query: 1109 ISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLP-LPMDPKK 1167
            ++ PPP +  A  P                               P T+  P +P  P  
Sbjct: 186  MAPPPPPVLEALSP-------------------------------PHTLSSPSIPTPPDF 214

Query: 1168 LAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSD 1227
            + P        L+      PP     P A  +    GT L   P G +TK        SD
Sbjct: 215  IPP-----APPLAFLAPPPPPVPAPAPPAPASPHTVGTRL--FPPGGVTKW------KSD 261

Query: 1228 SAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSY 1287
             A+  R                      +   +R    R  + PKG  +    + H L++
Sbjct: 262  VALNGR----------------------QAEATRASPPRSPAEPKGSALGPNPEPH-LTF 298

Query: 1288 EGGMSVTQCSKEDGRSSSGPPHETA-APKRTYDMMEGRVGRAISSASIEGLMGRAIPPER 1346
                 V   +    R+SS P  E   AP++     +    R     S        + P+R
Sbjct: 299  PRSFKVPPPTPV--RTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDR 356

Query: 1347 HSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPP-----------PP 1395
                    +       +  + +S  +A E           R GTPPP           PP
Sbjct: 357  APEPDCPGELKATAPASPRLGQSQSQADE-----------RAGTPPPAPPLPPPAPPLPP 405

Query: 1396 PSRDLTEAYKTQALGPLKLKPAH--EGLVATVKEAGRSIHEIPREELRHTPELPLAPRPL 1453
            P+  L  A       P   K AH   G   T K +  ++   P      +PE   +  P+
Sbjct: 406  PAPPLPPAAPPL---PCAQKAAHPPAGFTKTPKSSSPALKPKPNPP---SPENTASSAPV 459

Query: 1454 KEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEE 1513
                 +Q   L+ +  A   GS++ D R L   PG T  P        + +   R   +E
Sbjct: 460  DWRDPSQMEKLRNELAAYLCGSRRED-RFLSHRPGPTVAP-----QSKEGKKGPRLPEKE 513

Query: 1514 SLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPT 1573
            +L S P          A+  P  VPE  K        E   AP +  LP    +    PT
Sbjct: 514  TLLSLP----------AKDTPPGVPE--KSLGGSSLTETEAAP-SLTLPSVDYIPQDSPT 560

Query: 1574 PRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVP 1608
            P     S+   +   + +L+S   + AK    ++P
Sbjct: 561  P-----SVRQIRNELEARLSSAAEKEAKPSIGSLP 590



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 72/291 (24%), Positives = 100/291 (34%), Gaps = 49/291 (16%)

Query: 1968 AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIA-------------RTPAKNLAPHHA 2014
            A PP    LEP   PS    P P++  +S   T++               P   LAP   
Sbjct: 170  APPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPP 229

Query: 2015 SPDPPAPPASASDPHREKTQSKP------------FSIQELELRSLGYHGSSYSPEGVEP 2062
                PAPPA AS PH   T+  P             + ++ E        S   P+G   
Sbjct: 230  PVPAPAPPAPAS-PHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG-SA 287

Query: 2063 VSPVSSPSLTHDKGL----PKHLEELDKSHLEGELRP-KQPGPVKLGGEAAHLP---HLR 2114
            + P   P LT  +      P  +        E +  P K+ G  K       LP   H+R
Sbjct: 288  LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR 347

Query: 2115 PLPESQPSSSPLLQTAPGVKGHQRVVTLAQ-HISEVITQDYTRHHPQQLSAPLPAPLYSF 2173
            P  +  P  +P     P   G  +    A   + +  +Q   R      + PLP P    
Sbjct: 348  PASQVYPDRAP----EPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPL 403

Query: 2174 PGASCPVLDLRRPPSDLYLPPPDHGA-PARG---SPHSEGGKRSPEPNKTS 2220
            P  + P+     PP+   LP     A P  G   +P S      P+PN  S
Sbjct: 404  PPPAPPL-----PPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPS 449



 Score = 35.8 bits (81), Expect = 0.55
 Identities = 70/306 (22%), Positives = 100/306 (32%), Gaps = 54/306 (17%)

Query: 2159 PQQLSAP-LPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPN 2217
            P  LS+P +P P    P A  P+  L  PP  +  P P    PA  SPH+ G +  P   
Sbjct: 200  PHTLSSPSIPTPPDFIPPAP-PLAFLAPPPPPVPAPAP----PAPASPHTVGTRLFPPGG 254

Query: 2218 KTS-----VLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNT 2272
             T       L G +      SPP    EP  S           G   EP     +S    
Sbjct: 255  VTKWKSDVALNGRQAEATRASPPRSPAEPKGSAL---------GPNPEPHLTFPRSFKVP 305

Query: 2273 SQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLM 2332
               P   S +    +     K++   KK  +     P ++I +P +++            
Sbjct: 306  PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI-RPASQV------------ 352

Query: 2333 TYRSQAVQEHASTNMGLEAIIRKALMGKYDQWEE-------SPPLSANAFNPLNASASLP 2385
             Y  +A +      +   A     L     Q +E       +PPL   A      +  LP
Sbjct: 353  -YPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLP 411

Query: 2386 AAMPITAADGRSDHTLTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGD 2445
             A P      ++ H    P G  K            KS +P L     PPS  +  S   
Sbjct: 412  PAAPPLPCAQKAAHP---PAGFTKTP----------KSSSPALKPKPNPPSPENTASSAP 458

Query: 2446 CNRRTP 2451
             + R P
Sbjct: 459  VDWRDP 464



 Score = 35.0 bits (79), Expect = 0.94
 Identities = 64/248 (25%), Positives = 83/248 (33%), Gaps = 35/248 (14%)

Query: 1897 VEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPE 1956
            V P TP      ++S PV+ A   P       G T        + P    + A +V    
Sbjct: 304  VPPPTPV----RTSSIPVQEAQEAPRKEE---GATKKAPSRLPLPPSFHIRPASQVYPDR 356

Query: 1957 RPRADTGHAFLAKPPA--RSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHA 2014
             P  D      A  PA  R G   + +  +   P P  PP+         PA  L P   
Sbjct: 357  APEPDCPGELKATAPASPRLGQSQSQADERAGTPPP-APPLP-------PPAPPLPP--- 405

Query: 2015 SPDPPAPPASASDPHREKTQSKPFSIQELELRS---LGYHGSSYSPEGVEPVSPVSSPSL 2071
             P PP PPA+   P  +K    P    +    S   L    +  SPE     +PV     
Sbjct: 406  -PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464

Query: 2072 THDKGLPKHLEE-LDKSHLEGELRPKQPGPV-----KLGGEAAHLPHLRPLPESQPSSSP 2125
            +  + L   L   L  S  E      +PGP      K G +   LP    L      S P
Sbjct: 465  SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETL-----LSLP 519

Query: 2126 LLQTAPGV 2133
               T PGV
Sbjct: 520  AKDTPPGV 527



 Score = 32.7 bits (73), Expect = 4.6
 Identities = 40/135 (29%), Positives = 52/135 (38%), Gaps = 17/135 (12%)

Query: 784  TPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEET----AAAPPVEE 839
            T P    P   E    S     P   P P S S+PP    K E+EEE        PP E 
Sbjct: 936  TKPEPQAPVAWERVAPSNL---PQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEF 992

Query: 840  GEEQKPPAAEELAVDTGKAEEPVKSECTE-----EAEEG--PAKGKDAEAAEATAEGALK 892
              + +PPA     +  G+   P ++  ++      A  G  PA G     A A   GA  
Sbjct: 993  SNDPEPPAPALQYL--GRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGG 1050

Query: 893  AEKKEGGSGRATTAK 907
             E+  GG GR+   K
Sbjct: 1051 LERFSGG-GRSLIKK 1064


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.128    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 130,675,936
Number of Sequences: 37866
Number of extensions: 8678036
Number of successful extensions: 166108
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1376
Number of HSP's successfully gapped in prelim test: 2888
Number of HSP's that attempted gapping in prelim test: 48003
Number of HSP's gapped (non-prelim): 61845
length of query: 2524
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2405
effective length of database: 13,741,464
effective search space: 33048220920
effective search space used: 33048220920
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.