BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sapiens] (2462 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap... 4987 0.0 gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap... 4948 0.0 gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens] 1472 0.0 gi|209977080 REST corepressor 3 isoform a [Homo sapiens] 115 7e-25 gi|8922733 REST corepressor 3 isoform d [Homo sapiens] 115 7e-25 gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 112 4e-24 gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 112 4e-24 gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 106 3e-22 gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 106 3e-22 gi|7661892 REST corepressor 1 [Homo sapiens] 105 5e-22 gi|27734799 REST corepressor 2 [Homo sapiens] 103 3e-21 gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 101 1e-20 gi|209977084 REST corepressor 3 isoform c [Homo sapiens] 100 1e-20 gi|112382224 atrophin-1 like protein isoform a [Homo sapiens] 100 1e-20 gi|112382216 atrophin-1 like protein isoform a [Homo sapiens] 100 1e-20 gi|163965366 nascent polypeptide-associated complex alpha subuni... 96 3e-19 gi|210032580 SET domain containing 1B [Homo sapiens] 92 6e-18 gi|112382226 atrophin-1 like protein isoform b [Homo sapiens] 89 5e-17 gi|150170670 piccolo isoform 2 [Homo sapiens] 89 7e-17 gi|150378539 piccolo isoform 1 [Homo sapiens] 89 7e-17 gi|110349719 titin isoform N2-A [Homo sapiens] 88 1e-16 gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 88 1e-16 gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 87 2e-16 gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 87 3e-16 gi|149773456 hypothetical protein LOC643314 [Homo sapiens] 85 8e-16 gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 84 2e-15 gi|95147555 microtubule-associated protein 1A [Homo sapiens] 83 3e-15 gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho... 83 3e-15 gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 83 4e-15 gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 81 1e-14 >gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sapiens] Length = 2462 Score = 4987 bits (12937), Expect = 0.0 Identities = 2462/2462 (100%), Positives = 2462/2462 (100%) Query: 1 MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60 MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ Sbjct: 1 MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60 Query: 61 PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120 PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP Sbjct: 61 PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120 Query: 121 SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180 SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD Sbjct: 121 SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180 Query: 181 REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240 REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA Sbjct: 181 REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240 Query: 241 AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300 AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ Sbjct: 241 AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300 Query: 301 RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360 RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG Sbjct: 301 RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360 Query: 361 LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420 LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM Sbjct: 361 LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420 Query: 421 KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480 KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK Sbjct: 421 KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480 Query: 481 SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540 SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN Sbjct: 481 SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540 Query: 541 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ Sbjct: 541 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600 Query: 601 SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660 SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ Sbjct: 601 SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660 Query: 661 NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720 NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE Sbjct: 661 NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720 Query: 721 AEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT 780 AEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT Sbjct: 721 AEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT 780 Query: 781 PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840 PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK Sbjct: 781 PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840 Query: 841 AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 900 AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS Sbjct: 841 AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 900 Query: 901 SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQ 960 SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQ Sbjct: 901 SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQ 960 Query: 961 VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKP 1020 VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKP Sbjct: 961 VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKP 1020 Query: 1021 VFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH 1080 VFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH Sbjct: 1021 VFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH 1080 Query: 1081 DTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVT 1140 DTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVT Sbjct: 1081 DTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVT 1140 Query: 1141 MGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSIT 1200 MGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSIT Sbjct: 1141 MGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSIT 1200 Query: 1201 KGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVI 1260 KGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVI Sbjct: 1201 KGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVI 1260 Query: 1261 YEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEG 1320 YEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEG Sbjct: 1261 YEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEG 1320 Query: 1321 LMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPP 1380 LMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPP Sbjct: 1321 LMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPP 1380 Query: 1381 SRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEG 1440 SRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEG Sbjct: 1381 SRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEG 1440 Query: 1441 SITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLK 1500 SITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLK Sbjct: 1441 SITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLK 1500 Query: 1501 SRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRL 1560 SRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRL Sbjct: 1501 SRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRL 1560 Query: 1561 QEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIP 1620 QEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIP Sbjct: 1561 QEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIP 1620 Query: 1621 LAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDY 1680 LAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDY Sbjct: 1621 LAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDY 1680 Query: 1681 ITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPG 1740 ITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPG Sbjct: 1681 ITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPG 1740 Query: 1741 TPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDRE 1800 TPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDRE Sbjct: 1741 TPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDRE 1800 Query: 1801 REKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQD 1860 REKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQD Sbjct: 1801 REKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQD 1860 Query: 1861 ALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVY 1920 ALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVY Sbjct: 1861 ALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVY 1920 Query: 1921 PTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVS 1980 PTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVS Sbjct: 1921 PTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVS 1980 Query: 1981 GHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYS 2040 GHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYS Sbjct: 1981 GHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYS 2040 Query: 2041 PEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPL 2100 PEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPL Sbjct: 2041 PEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPL 2100 Query: 2101 PESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGA 2160 PESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGA Sbjct: 2101 PESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGA 2160 Query: 2161 SCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPE 2220 SCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPE Sbjct: 2161 SCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPE 2220 Query: 2221 GMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQE 2280 GMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQE Sbjct: 2221 GMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQE 2280 Query: 2281 INKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKA 2340 INKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKA Sbjct: 2281 INKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKA 2340 Query: 2341 LMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPS 2400 LMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPS Sbjct: 2341 LMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPS 2400 Query: 2401 SAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSD 2460 SAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSD Sbjct: 2401 SAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSD 2460 Query: 2461 SE 2462 SE Sbjct: 2461 SE 2462 >gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sapiens] Length = 2524 Score = 4948 bits (12835), Expect = 0.0 Identities = 2461/2525 (97%), Positives = 2461/2525 (97%), Gaps = 64/2525 (2%) Query: 1 MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60 MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ Sbjct: 1 MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60 Query: 61 PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120 PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP Sbjct: 61 PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120 Query: 121 SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180 SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD Sbjct: 121 SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180 Query: 181 REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240 REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA Sbjct: 181 REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240 Query: 241 AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300 AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ Sbjct: 241 AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300 Query: 301 RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360 RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG Sbjct: 301 RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360 Query: 361 LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420 LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM Sbjct: 361 LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420 Query: 421 KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480 KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK Sbjct: 421 KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480 Query: 481 SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540 SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN Sbjct: 481 SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540 Query: 541 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ Sbjct: 541 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600 Query: 601 SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660 SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ Sbjct: 601 SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660 Query: 661 NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720 NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE Sbjct: 661 NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720 Query: 721 AEA-----------------TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP 763 AEA TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP Sbjct: 721 AEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP 780 Query: 764 GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 823 GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG Sbjct: 781 GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 840 Query: 824 EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 883 EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS Sbjct: 841 EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 900 Query: 884 GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 943 GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP Sbjct: 901 GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 960 Query: 944 LDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1003 LDLKQLKQRAAAIPPI VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR Sbjct: 961 LDLKQLKQRAAAIPPI-VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1019 Query: 1004 GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP 1063 GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP Sbjct: 1020 GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP 1079 Query: 1064 SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ 1123 SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ Sbjct: 1080 SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ 1139 Query: 1124 LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA 1183 LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA Sbjct: 1140 LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA 1199 Query: 1184 SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP 1243 SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP Sbjct: 1200 SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP 1259 Query: 1244 SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD 1303 SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD Sbjct: 1260 SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD 1319 Query: 1304 MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR 1363 MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR Sbjct: 1320 MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR 1379 Query: 1364 REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE 1423 REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE Sbjct: 1380 REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE 1439 Query: 1424 LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV 1483 LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV Sbjct: 1440 LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV 1499 Query: 1484 MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG 1543 MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG Sbjct: 1500 MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG 1559 Query: 1544 HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE 1603 HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE Sbjct: 1560 HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE 1619 Query: 1604 HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG 1663 HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG Sbjct: 1620 HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG 1679 Query: 1664 YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII 1723 YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII Sbjct: 1680 YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII 1739 Query: 1724 DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS 1783 DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS Sbjct: 1740 DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS 1799 Query: 1784 SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1843 SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA Sbjct: 1800 SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1859 Query: 1844 SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT 1903 SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT Sbjct: 1860 SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT 1919 Query: 1904 FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA 1963 FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA Sbjct: 1920 FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA 1979 Query: 1964 SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS 2023 SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS Sbjct: 1980 SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS 2039 Query: 2024 IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG 2083 IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG Sbjct: 2040 IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG 2099 Query: 2084 PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP 2143 PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP Sbjct: 2100 PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP 2159 Query: 2144 QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT 2203 QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT Sbjct: 2160 QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT 2219 Query: 2204 SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF 2263 SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF Sbjct: 2220 SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF 2279 Query: 2264 SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV 2323 SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV Sbjct: 2280 SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV 2339 Query: 2324 QEHASTNMGLEAIIRKALM----------------------------------------- 2342 QEHASTNMGLEAIIRKALM Sbjct: 2340 QEHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDH 2399 Query: 2343 -----GGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED 2397 GGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED Sbjct: 2400 TLTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED 2459 Query: 2398 RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET 2457 RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET Sbjct: 2460 RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET 2519 Query: 2458 LSDSE 2462 LSDSE Sbjct: 2520 LSDSE 2524 >gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens] Length = 2440 Score = 1472 bits (3812), Expect = 0.0 Identities = 1080/2648 (40%), Positives = 1422/2648 (53%), Gaps = 395/2648 (14%) Query: 1 MSGSTQPVAQTWRATEP-RYPPHSLSYPVQIARTHTDVGLLEYQ--HHSRDYASHLSPGS 57 MS S P Q +TE RYPPHS+ Y R + + +Y+ H AS L Sbjct: 1 MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQ 60 Query: 58 IIQPQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPD-- 115 Q RRRPSLLSEF PG++R QE R + P + + +ESKRPRLE + D Sbjct: 61 QQQQLRRRPSLLSEFHPGSDRPQER--RTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSH 118 Query: 116 ---------PLLRPSPLLATGQPAGSEDLTKDRSLTGKLE-PVSPPSPPHTDPELELVPP 165 PL+ P P G A S D KD + GK E P SP S + P Sbjct: 119 FQRVSAAVLPLVHPLP---EGLRA-SADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPS 174 Query: 166 RLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRS 225 +LSKEELIQ+MDRVDREI VEQQI KLKKKQQQLEEEAAKPPEPEKPVSPPP+E KHRS Sbjct: 175 KLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRS 234 Query: 226 LVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFK 285 +VQIIYDENRKKAE AH+I EGLGP+VELPLYNQPSDT+ YHENIK NQ MRKKLIL+FK Sbjct: 235 IVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIKTNQVMRKKLILFFK 294 Query: 286 RRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRE 345 RRNHARKQ EQK CQRYDQLMEAWEKKV+RIENNPRR+AKESK REYYEKQFPEIRKQRE Sbjct: 295 RRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQRE 354 Query: 346 LQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQ 405 QER Q RVGQRG+GLS + ARSEHE+SEIIDGLSEQEN EKQMRQL+VIPPM++DA+Q+ Sbjct: 355 QQERFQ-RVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQR 413 Query: 406 RIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAE 465 R+KFINMNGLM DPMKVYKDRQ MN+W++ EKE F++KF+QHPKNFGLIAS+LERK+V + Sbjct: 414 RVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPD 473 Query: 466 CVLYYYLTKKNENYKSLVRRSY-RRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKE 524 CVLYYYLTKKNENYK+LVRR+Y +RRG++QQ + Q+++ +++++ ++ + EK E+E Sbjct: 474 CVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEE--DKAEKTEKKEEE 531 Query: 525 KEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITR 584 K+ E EK+E++ EN KE K+K D T+ E+ +E+E +GRKTANSQGRRKGRITR Sbjct: 532 KKDEEEKDEKEDSKENTKE---KDKIDGTA-EETEEREQATPRGRKTANSQGRRKGRITR 587 Query: 585 SMANEANSEEAITPQQS----------AELASMELNESSRWTEEEMETAKKGLLEHGRNW 634 SM NEA + A + E S E E+SRWTEEEME AKKGL+EHGRNW Sbjct: 588 SMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLVEHGRNW 647 Query: 635 SAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEA 694 +AIA+MVG+K+ +QCKNFYFNYK+R NLD +LQQHK K ++ R + + AS + Sbjct: 648 AAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVS 707 Query: 695 AFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPK--- 751 A EDE++EAS NEEE E++E S+ SP E A G P Sbjct: 708 A----QEDEDIEAS----NEEENPEDSEVEAVKPSE----DSP--ENATSRGNTEPAVEL 753 Query: 752 PPATLGADGPPPG---PPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE 808 P T A P P T P ED T+ +++ A T + V +E Sbjct: 754 EPTTETAPSTSPSLAVPSTKPAEDESVETQ---VNDSISAET--------AEQMDVDQQE 802 Query: 809 EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEA 868 EE + P PPA + +VD E V + E K +D + A Sbjct: 803 HSAEEGSVCDP--------PPATKADSVD---VEVRVPENHASKVEGDNTKERDLDRASE 851 Query: 869 TAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSP---RP 925 E ++ + A+ D+DSSATCSADE + +G + + + P +P Sbjct: 852 KVE----PRDEDLVVAQQINAQRPEPQSDNDSSATCSADE--DVDGEPERQRMFPMDSKP 905 Query: 926 SLLTPTGDPRANASPQK--PLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPP 983 SLL PTG +SP K PLDL QL+ RAA IPP+ P P P Sbjct: 906 SLLNPTGSILV-SSPLKPNPLDLPQLQHRAAVIPPM----------VSCTPCN-IPIGTP 953 Query: 984 PPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSG 1043 + S+ + R D E PC TS Sbjct: 954 VSGYALYQRHIKAMHESALLEEQRQRQEQIDLECRS---------------STSPCGTS- 997 Query: 1044 LPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSA 1103 P EV++ +PH + P G LP T RP P PP I + ++S Sbjct: 998 -KSPNREWEVLQPAPH----QVITNLPEGVRLP-----TTRPTRPPPPLIPSSKTTVASE 1047 Query: 1104 KHPSVLERQIGAISQG-----MSVQLHVPYSEHAKAP-VGPVTMGLPLPMDPKKLAPFSG 1157 K ++ G+ISQG ++ Y++ P VG +++GLP + K A Sbjct: 1048 KPSFIMG---GSISQGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPY 1104 Query: 1158 VKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYR 1217 +KQE+ SPR Q PE L V AQ V+RGTA G++ GSIT+G P++++ +S + R Sbjct: 1105 IKQEEFSPRSQNSQPEGLLV-RAQHEGVVRGTA-GAIQEGSITRGTPTSKISVESIPSLR 1162 Query: 1218 GSITHGTPA--------DVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVL 1269 GSIT GTPA + L KG+I+R+ EDS ++GRE++ KGHVIYEGK GH+L Sbjct: 1163 GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSP--EKGREEAASKGHVIYEGKSGHIL 1220 Query: 1270 SYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAIS------SASIEGLMG 1323 SY+ + +G S HE + KR+Y+ +EG + + +S SA +EGL+ Sbjct: 1221 SYDNIKNA-----REGTRSPRTAHEISL-KRSYESVEGNIKQGMSMRESPVSAPLEGLIC 1274 Query: 1324 RAIPPERHSPH-HLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPSR 1382 RA+P R SPH LKE+ + GSI QG PR+ E+ ED L + K +KRE PP R Sbjct: 1275 RALP--RGSPHSDLKERTVLSGSIMQGTPRATTESFEDGL-KYPKQIKRES-----PPIR 1326 Query: 1383 DLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREEL-----RHTPELPLAPRPL 1437 A K KP ++G + T+KE GRSIHEIPR+++ R TPE+ + RP+ Sbjct: 1327 AFEGAI-------TKGKP-YDG-ITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPI 1377 Query: 1438 KEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMAD-ARALERACYE 1496 EGSI+QGTP+K+D S + KH+V+SLI P + + PL+++ + + +ER YE Sbjct: 1378 IEGSISQGTPIKFDNN-SGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYE 1436 Query: 1497 -----ESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGA-----PFAGHLP 1546 E+++SR + SSG S+ R + E K + SP Y+D A + + Sbjct: 1437 DVKAGETVRSRHTSVVSSGPSVLRST---LHEAPKAQLSPGIYDDTSARRTPVSYQNTMS 1493 Query: 1547 RGSPVTTREPTPRLQEGSLSSSKA-SQDRKLTSTPRE----IAKSPHSTVPEHHPHPISP 1601 RGSP+ R + ++SS+K+ + +RK T TP + AKSP V H SP Sbjct: 1494 RGSPMMN-----RTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSH--SP 1546 Query: 1602 YEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLD-AAAAYYLPRHLAPNPTYPHLYPPYL 1660 ++ RG + ++YRSH+P DP ++P LD AAAAY R L+P P YP Y Y Sbjct: 1547 FDPHHRGSTAGEVYRSHLPTHLDP-AMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLY- 1604 Query: 1661 IRGYPDTAALEN-RQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGP 1719 A+EN RQTI+NDYITSQQM N R D+ RGLSPRE L L Y A Sbjct: 1605 --------AMENTRQTILNDYITSQQMQVNL------RPDVARGLSPREQPLGLPYPA-T 1649 Query: 1720 RGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSR-HSSSPLSPGGPTHLTK 1778 RGIIDL+ +P +LVP GT MDR+ Y+P F R ++S+ +SPG PTHL Sbjct: 1650 RGIIDLTNMPP-TILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGHPTHL-- 1706 Query: 1779 PTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGS 1838 +S+ERER+R+RE++R+RER I +++ + RPG+EQ Sbjct: 1707 -AAAASAEREREREREKERERER---IAAASSDL----YLRPGSEQ-------------- 1744 Query: 1839 SSRPASHSHAHQHSPISPRTQDA-LQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP 1897 RP SH + SP S RTQ+ LQQRPSV T +IT ++P+ + P Sbjct: 1745 PGRPGSHGYVRSPSP-SVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGP 1803 Query: 1898 V----RPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPR-------------VARPE 1940 PA+ + A L +D V KE+ A E Sbjct: 1804 SISQGLPASRYNTAADA-LAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSE 1862 Query: 1941 RPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLV-----------PPVSGHATIARTP 1989 + + + + K + ++ PS +P V PP S + RT Sbjct: 1863 QQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVYSEAGKDKGPPPKSRYEEELRTR 1922 Query: 1990 AKN--LAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPV 2047 K A + AS D +QS S SL H + +E + Sbjct: 1923 GKTTITAANFIDVIITRQIASDKDARERGSQSSDSS------SSLSSHRYETPSDAIEVI 1976 Query: 2048 SPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSS 2107 SP SSP+ +K E + + E + + GP L H RP Q S Sbjct: 1977 SPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGP---------LHHYRP---QQESP 2024 Query: 2108 SPLLQTAPG--------VKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPG 2159 SP Q P V R++TLA HI ++ITQD+ R+ P P +F Sbjct: 2025 SPQQQLPPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVSS-QTPQQPPTSTFQN 2083 Query: 2160 ASCPVLD--LRRPPSDLYLPPPD-----HGAP-ARGSPH-----SEGGKRSPEPNKTSVL 2206 + ++ +R S+ Y P H P +R SP S G + P ++ V Sbjct: 2084 SPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHV- 2142 Query: 2207 GGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKL 2266 + EP+SPP+ H + LL + G + R ++SPG+ S P+FF+KL Sbjct: 2143 --SSEPYEPISPPQ--VPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTKL 2198 Query: 2267 TESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEH 2326 E+ S MVKSKKQEI +KLN+ + + +QPGTEIFN+PA+T +G ++ R + + Sbjct: 2199 -ENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGSVSSRGHSFADP 2257 Query: 2327 ASTNMGLEAIIRKALMG------------------------------------------- 2343 AS N+GLE IIRKALMG Sbjct: 2258 AS-NLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSP 2316 Query: 2344 -GGG--KAKVSGRPSSRKAKSPAP--GLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDR 2398 GG K K+ + +SRK+KSP P G +RP SVSSVHSEGD +R+TP WEDR Sbjct: 2317 HSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTP--GWAWEDR 2374 Query: 2399 PSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSG-PLAGPH---HAWDEEPKPLLCSQ 2454 PSS GST FPYNPL MR+ + ++PP P A S A PH W+ EP PLL +Q Sbjct: 2375 PSSTGSTQFPYNPLTMRM---LSSTPPTPIACAPSAVNQAAPHQQNRIWEREPAPLLSAQ 2431 Query: 2455 YETLSDSE 2462 YETLSDS+ Sbjct: 2432 YETLSDSD 2439 >gi|209977080 REST corepressor 3 isoform a [Homo sapiens] Length = 553 Score = 115 bits (287), Expect = 7e-25 Identities = 109/413 (26%), Positives = 166/413 (40%), Gaps = 45/413 (10%) Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491 W+ ++K F + F H K+F I L KT+A V YYY KK + SL+ R R Sbjct: 147 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 203 Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545 K + Q ++ PM + + +KE +KE E+ V+ K L Sbjct: 204 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 260 Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592 + K G +++ VA S AN+ R+ + R + N Sbjct: 261 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 320 Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647 A+ + + + ES+ RWT EE A +G+ ++G+++ AIA ++G+KTV Sbjct: 321 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 380 Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707 Q KNF+ NY++R NL+E+LQ+ E E+ + A E + V Sbjct: 381 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 429 Query: 708 SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT 767 SG S +EEE + +A + S T A N P P P Sbjct: 430 SGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQ 489 Query: 768 PPPEDIPAP-TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819 PPP A +P P P PP P+ S PP + P+ PP Sbjct: 490 PPPLQQQARFIQPRP---TLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPP 539 Score = 42.4 bits (98), Expect = 0.006 Identities = 89/439 (20%), Positives = 152/439 (34%), Gaps = 108/439 (24%) Query: 615 WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME 674 WT E+ ++ HG+++ I +M+ KT++ +Y+++KK ++ ++ + K+ Sbjct: 147 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLA 206 Query: 675 KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734 N G+ ++ VEE N SD + Sbjct: 207 NRHN--------------------------------QGDSDDDVEETHPMDGNDSDYD-- 232 Query: 735 PSPHTEAAKDTGQNGPKPPATLGADG------------------PPPGPPTPPPEDIPAP 776 P EA K+ P + +G PP G + + Sbjct: 233 --PKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVS 290 Query: 777 TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG-EEQKPPAAEELA 835 P A+ + K+ +A +E G EE KPP + + Sbjct: 291 CSPNAANTILRQLDMELISLKRQV------QNAKQVNSALKQKMEGGIEEFKPPESNQKI 344 Query: 836 VDTGKAEEPVKSECTEEAEEGPAK-GKDAEAA---------------------EATAEGA 873 EE + A +G K GKD +A E Sbjct: 345 NARWTTEEQLL------AVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEV 398 Query: 874 LKAEKKEGGSGRATTAKSSGAPQDSDSSATC----SADEVDEAEGGDKNRLLSPRP---- 925 L+ + E G+ +A+ +S +++ S++ S DE +EA+ R L P P Sbjct: 399 LQEWEAEQGT-QASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPS 457 Query: 926 SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPA-PPP 984 S TPT P A + PL L+ A P + + P ++ A +P P PP Sbjct: 458 STPTPTA-PIATLNQPPPL----LRPTLPAAPALH--RQPPPLQQQARFIQPRPTLNQPP 510 Query: 985 PQNLQPESDAPQQPGSSPR 1003 P ++P + P P +PR Sbjct: 511 PPLIRPANSMP--PRLNPR 527 Score = 38.1 bits (87), Expect = 0.11 Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 6/118 (5%) Query: 986 QNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLP 1045 Q Q + G + S P+ + E E+ A +A + G P S P Sbjct: 406 QGTQASNGDASTLGEETKSASNVPSGKSTDEEEE-----AQTPQAPRTLGPSPPAPSSTP 460 Query: 1046 FPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSA 1103 P P + P P+ AP H P L AR + PRP PPPLI A Sbjct: 461 TPTAPIATLNQPPPLLRPT-LPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPA 517 >gi|8922733 REST corepressor 3 isoform d [Homo sapiens] Length = 495 Score = 115 bits (287), Expect = 7e-25 Identities = 109/413 (26%), Positives = 166/413 (40%), Gaps = 45/413 (10%) Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491 W+ ++K F + F H K+F I L KT+A V YYY KK + SL+ R R Sbjct: 89 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 145 Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545 K + Q ++ PM + + +KE +KE E+ V+ K L Sbjct: 146 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 202 Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592 + K G +++ VA S AN+ R+ + R + N Sbjct: 203 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 262 Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647 A+ + + + ES+ RWT EE A +G+ ++G+++ AIA ++G+KTV Sbjct: 263 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 322 Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707 Q KNF+ NY++R NL+E+LQ+ E E+ + A E + V Sbjct: 323 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 371 Query: 708 SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT 767 SG S +EEE + +A + S T A N P P P Sbjct: 372 SGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQ 431 Query: 768 PPPEDIPAP-TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819 PPP A +P P P PP P+ S PP + P+ PP Sbjct: 432 PPPLQQQARFIQPRP---TLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPP 481 Score = 42.4 bits (98), Expect = 0.006 Identities = 89/439 (20%), Positives = 152/439 (34%), Gaps = 108/439 (24%) Query: 615 WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME 674 WT E+ ++ HG+++ I +M+ KT++ +Y+++KK ++ ++ + K+ Sbjct: 89 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLA 148 Query: 675 KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734 N G+ ++ VEE N SD + Sbjct: 149 NRHN--------------------------------QGDSDDDVEETHPMDGNDSDYD-- 174 Query: 735 PSPHTEAAKDTGQNGPKPPATLGADG------------------PPPGPPTPPPEDIPAP 776 P EA K+ P + +G PP G + + Sbjct: 175 --PKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVS 232 Query: 777 TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG-EEQKPPAAEELA 835 P A+ + K+ +A +E G EE KPP + + Sbjct: 233 CSPNAANTILRQLDMELISLKRQV------QNAKQVNSALKQKMEGGIEEFKPPESNQKI 286 Query: 836 VDTGKAEEPVKSECTEEAEEGPAK-GKDAEAA---------------------EATAEGA 873 EE + A +G K GKD +A E Sbjct: 287 NARWTTEEQLL------AVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEV 340 Query: 874 LKAEKKEGGSGRATTAKSSGAPQDSDSSATC----SADEVDEAEGGDKNRLLSPRP---- 925 L+ + E G+ +A+ +S +++ S++ S DE +EA+ R L P P Sbjct: 341 LQEWEAEQGT-QASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPS 399 Query: 926 SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPA-PPP 984 S TPT P A + PL L+ A P + + P ++ A +P P PP Sbjct: 400 STPTPTA-PIATLNQPPPL----LRPTLPAAPALH--RQPPPLQQQARFIQPRPTLNQPP 452 Query: 985 PQNLQPESDAPQQPGSSPR 1003 P ++P + P P +PR Sbjct: 453 PPLIRPANSMP--PRLNPR 469 Score = 38.1 bits (87), Expect = 0.11 Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 6/118 (5%) Query: 986 QNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLP 1045 Q Q + G + S P+ + E E+ A +A + G P S P Sbjct: 348 QGTQASNGDASTLGEETKSASNVPSGKSTDEEEE-----AQTPQAPRTLGPSPPAPSSTP 402 Query: 1046 FPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSA 1103 P P + P P+ AP H P L AR + PRP PPPLI A Sbjct: 403 TPTAPIATLNQPPPLLRPT-LPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPA 459 >gi|189181720 proteoglycan 4 isoform B [Homo sapiens] Length = 1363 Score = 112 bits (280), Expect = 4e-24 Identities = 164/739 (22%), Positives = 256/739 (34%), Gaps = 85/739 (11%) Query: 495 QQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKE-EEKPEVENDKEDLLKEKT--- 550 ++ + Q+ SS K + K A +E ++K +V+++K++ K+K Sbjct: 115 EEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 174 Query: 551 -----DDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ-SAEL 604 + SG DN + + T +++ +IT A N ++ P +++ Sbjct: 175 PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITT--AKPINPRPSLPPNSDTSKE 232 Query: 605 ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664 S+ +N+ + +E T K G+ + A+ S + K+ K Sbjct: 233 TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK------- 285 Query: 665 ILQQHKLKME---KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEA 721 +L + K E K K+ P E A+ P +E + + E A Sbjct: 286 VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP----KEPTPTTIKSAPTTPKEPA 341 Query: 722 EATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 781 T ++ T P+P T K+ PK PA P P P P EP P Sbjct: 342 PTTTKSAPTTPKEPAPTT--TKEPAPTTPKEPAPTTTKEPAPTTTKSAPT---TPKEPAP 396 Query: 782 ASEATGAPTPP--PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839 + APT P PAP +P P P PKE AP + E P A ++ A T Sbjct: 397 TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPK--EPAPTAPKKPAPTTP 454 Query: 840 KAEEPVK-SECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDS 898 K P E + P+ E A T + A K+ + TT + P++ Sbjct: 455 KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT---TTKSAPTTPKEP 511 Query: 899 DSSATCSADEVDEAEGGD----KNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAA 954 + T E K +P+ T +P A + +KP K+ A Sbjct: 512 SPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTP-KEPAP 569 Query: 955 AIP----PIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQP-----------ESDAPQQPG 999 P P K+ E APT P PAP P+ L P E AP P Sbjct: 570 TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 629 Query: 1000 SSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPH 1059 ++ + PAP KE PA + P P P P + + +P Sbjct: 630 AAAPNTPKEPAPTTPKE-------PAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 682 Query: 1060 AP--------------DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKH 1105 P +P++ + P P G T P P P T P P Sbjct: 683 TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT-PKEPAPTTPKEPAPTTPKGTA 741 Query: 1106 PSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSP 1165 P+ L+ + + + P + K P T P P PK+ AP + + +P Sbjct: 742 PTTLKEPAPTTPKKPAPKELAPTT--TKGPTS-TTSDKPAPTTPKETAPTTPKEPAPTTP 798 Query: 1166 RGQAGPPESLGVPTAQEAS 1184 + A PT E S Sbjct: 799 KKPAPTTPETPPPTTSEVS 817 Score = 96.3 bits (238), Expect = 3e-19 Identities = 111/442 (25%), Positives = 142/442 (32%), Gaps = 69/442 (15%) Query: 675 KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734 KE KK AP E A P E + + E A T ++ T Sbjct: 439 KEPAPTAPKKPAPTTPKEPA---PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 495 Query: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-----TPASEATGAP 789 P+P T + T P P T P P P PAPT P T E Sbjct: 496 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 555 Query: 790 TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP-VKSE 848 T PAP +P P P PK ETA P ++ P E+LA T + P E Sbjct: 556 TKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEE 606 Query: 849 CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908 E P E A T + A KE A T AP A + E Sbjct: 607 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTPKE 662 Query: 909 VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968 +P+ + T +P A +P+KP + + P + Sbjct: 663 TAPT---------TPKGTAPTTLKEP-APTTPKKPAPKE--------LAPTTTKEPTSTT 704 Query: 969 REDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025 + APT P AP P P P+ AP P + + PAP K+ PA Sbjct: 705 CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK-------PA 757 Query: 1026 FAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARP 1085 A P TS P P P+E +P P P+ P Sbjct: 758 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------------------P 798 Query: 1086 VLPRPPTISNPPPLISSAKHPS 1107 P P T PPP S P+ Sbjct: 799 KKPAPTTPETPPPTTSEVSTPT 820 Score = 72.0 bits (175), Expect = 7e-12 Identities = 123/544 (22%), Positives = 172/544 (31%), Gaps = 108/544 (19%) Query: 766 PTPPPEDIPAPTEPTPASEATGAPTP-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGE 824 PT PP AP P+ AS+ + T P PP+ V+ EE EE + V E + Sbjct: 69 PTSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHS----VSENQ 123 Query: 825 EQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD-----------------AEAAE 867 E ++ + T + + K+ + K KD EA Sbjct: 124 ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGS 183 Query: 868 ATAEGALKA---------EKKEGGSGRATTAK----SSGAPQDSDSS------------- 901 G K K S + TTAK P +SD+S Sbjct: 184 GLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTV 243 Query: 902 ---ATCSADEVDEAEGGDKNR----------------------LLSPRPSLLTPTGDPRA 936 T + ++ +G +K L P P T T P A Sbjct: 244 ETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-A 302 Query: 937 NASPQKPLDLKQLKQRAAAIP----PIQVTKVHEPPREDA-APTKPAPPAPPPPQNLQPE 991 +P++P K+ A+ P P + P+E A TK AP P P + Sbjct: 303 LTTPKEPTPTTP-KEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 361 Query: 992 SDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPR 1051 AP P ++ PAP K A P A P P T P P P+ Sbjct: 362 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP-----APTTPKKPAPTTPKEPAPTTPK 416 Query: 1052 EVIKASPHAPDPSAFSYAP--PGHPLPLGLHDTA--RPVLPRPPTISNPPPLISSAKHPS 1107 E +P P P+ AP P P P A P P P T P P + P+ Sbjct: 417 EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 476 Query: 1108 VLERQIGAISQGMSVQLHVPYSEHAK-APV-----GPVTMGLPLPMDPKKLAPFSGVKQE 1161 + ++ P K AP P T P P PK+ AP + K Sbjct: 477 TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 536 Query: 1162 QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSIT 1221 +P+ A PT + T P+ P ++A T +T Sbjct: 537 PTTPKEPAPTTPKEPAPTTTKKP------------APTTPKEPAPTTPKETAPTTPKKLT 584 Query: 1222 HGTP 1225 TP Sbjct: 585 PTTP 588 Score = 63.5 bits (153), Expect = 2e-09 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%) Query: 1729 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1788 P P P P T + P P P + + + PT KP T+ E Sbjct: 399 PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 458 Query: 1789 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844 +E +E S T + TT + AP T++ + ++ S P + Sbjct: 459 PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 515 Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1904 +P P + P+ T + T + PT + + ++P PA T Sbjct: 516 TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 571 Query: 1905 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1950 P T L P + P K AP PE P T A Sbjct: 572 PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 631 Query: 1951 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2005 +P + EPA P+ EP P P + T T P P +P PAP Sbjct: 632 APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 689 Query: 2006 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2055 A +E T + KP + +P+G P +P P+ Sbjct: 690 KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 734 Query: 2056 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2110 T KG P L+E PK+P P +L P +P P + ++P Sbjct: 735 TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 788 Query: 2111 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2165 T P T SEV T T+ P ++ P S P L Sbjct: 789 TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 839 Query: 2166 DLRRPPSDLYLPPPDHGAPARGSP 2189 P L P + G P +P Sbjct: 840 SAEPTPKALENSPKEPGVPTTKTP 863 Score = 60.1 bits (144), Expect = 3e-08 Identities = 81/339 (23%), Positives = 121/339 (35%), Gaps = 48/339 (14%) Query: 743 KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP---TPASEATGAPTPP--PAPPS 797 K+ PK PA PT D PAPT P P + APT P PAP + Sbjct: 746 KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTT 805 Query: 798 PSAPPPV-----VPKEEKEEETAAAPPVEE----GEEQKPPAAE----ELAVDTGKAEEP 844 P PPP P KE T P E E P A E E V T K Sbjct: 806 PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 865 Query: 845 VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904 K E T A++ + +D T A K K+ ATT + + ++S T Sbjct: 866 TKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----TATTTEKT-----TESKITA 914 Query: 905 SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964 + +V D +L T T P+ + +K + ++ + P + K Sbjct: 915 TTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT-KKTITTTEIMNK-----PEETAK- 965 Query: 965 HEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP-PADKEAEKPVFF 1023 P++ A +K P P P + + ++P + PR + P P + P Sbjct: 966 ---PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN 1022 Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1062 P L T+ P P ++++ +P + D Sbjct: 1023 PTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1055 Score = 57.0 bits (136), Expect = 2e-07 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%) Query: 1732 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1791 P L P TP T + + P P P + + S+P +P P PTTT S+ Sbjct: 301 PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 351 Query: 1792 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1851 +E +E + TT E AP T++ + ++ S P + Sbjct: 352 PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 405 Query: 1852 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1909 +P P + P+ T + T EP+ PT + + ++P +PA T P PA Sbjct: 406 TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 460 Query: 1910 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1969 P EP + P P+ P T K + EPA + +K Sbjct: 461 TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 503 Query: 1970 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2022 + P P + A T K AP +P PAP P + +P T+ Sbjct: 504 APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 561 Query: 2023 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2080 + + + + +P+ + P +P T +K P EEL + E P+ Sbjct: 562 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 621 Query: 2081 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2115 +P P A + P P P + +P P Sbjct: 622 EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 655 Score = 56.2 bits (134), Expect = 4e-07 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%) Query: 1549 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1608 +P TT+EP P + ++ T + K P T P+ P P +P E Sbjct: 356 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 410 Query: 1609 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1662 P PT+ P A P+ AP PT P P + Sbjct: 411 -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 463 Query: 1663 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1721 T E T + T+ + A +P+E S P Sbjct: 464 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 521 Query: 1722 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1780 P P P P T + P P P +++ +P +P P T K T Sbjct: 522 -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 575 Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1836 ++ ++ E+ EK TT E AP P T + + Sbjct: 576 APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 633 Query: 1837 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1896 + PA +P P + P+ T T + + PT L+ + ++ Sbjct: 634 NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 683 Query: 1897 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1949 P +PA P T P T D PT + P + AP + P G A Sbjct: 684 PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 743 Query: 1950 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002 K PA L P ++ S P + T TP + P +P Sbjct: 744 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 800 Query: 2003 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2062 PAP + P S P + +E P + S+P L+ + P Sbjct: 801 PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 845 Query: 2063 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2106 K LE PK+PG AA P LR PE + P Sbjct: 846 KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 895 Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166 + T ++ ++ TQD T L AP + + + Sbjct: 896 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 955 Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2226 + P + P D ++ + +P+P K P P+ T Sbjct: 956 IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 993 Query: 2227 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2284 + P + + P +M S P TS+ + T + SK E+N K Sbjct: 994 -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1052 Score = 53.5 bits (127), Expect = 2e-06 Identities = 80/342 (23%), Positives = 120/342 (35%), Gaps = 47/342 (13%) Query: 724 TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAPTEPTPA 782 T +S T P+P T K+T PK PA P P P TPPP T T Sbjct: 766 TKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK 823 Query: 783 SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842 T +P + P SA P E +E K PAA + + T + Sbjct: 824 EPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEMTTTAKD 876 Query: 843 EPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG--------RATTAK 890 + + + E A K A E T E + A + S + TT K Sbjct: 877 KTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 936 Query: 891 SSG-APQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 946 ++ AP+ + + T + E+ E K+R + + + P +A P+KP Sbjct: 937 TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKA---PKKPTST 993 Query: 947 KQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1006 K+ K +P ++ K PR+ T P P + + +P +P K Sbjct: 994 KKPK----TMPRVRKPKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKL 1046 Query: 1007 RSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1037 P ++ E E P VF P + LP P Sbjct: 1047 VEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1088 >gi|67190163 proteoglycan 4 isoform A [Homo sapiens] Length = 1404 Score = 112 bits (280), Expect = 4e-24 Identities = 164/739 (22%), Positives = 256/739 (34%), Gaps = 85/739 (11%) Query: 495 QQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKE-EEKPEVENDKEDLLKEKT--- 550 ++ + Q+ SS K + K A +E ++K +V+++K++ K+K Sbjct: 156 EEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 215 Query: 551 -----DDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ-SAEL 604 + SG DN + + T +++ +IT A N ++ P +++ Sbjct: 216 PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITT--AKPINPRPSLPPNSDTSKE 273 Query: 605 ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664 S+ +N+ + +E T K G+ + A+ S + K+ K Sbjct: 274 TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK------- 326 Query: 665 ILQQHKLKME---KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEA 721 +L + K E K K+ P E A+ P +E + + E A Sbjct: 327 VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP----KEPTPTTIKSAPTTPKEPA 382 Query: 722 EATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 781 T ++ T P+P T K+ PK PA P P P P EP P Sbjct: 383 PTTTKSAPTTPKEPAPTT--TKEPAPTTPKEPAPTTTKEPAPTTTKSAPT---TPKEPAP 437 Query: 782 ASEATGAPTPP--PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839 + APT P PAP +P P P PKE AP + E P A ++ A T Sbjct: 438 TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPK--EPAPTAPKKPAPTTP 495 Query: 840 KAEEPVK-SECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDS 898 K P E + P+ E A T + A K+ + TT + P++ Sbjct: 496 KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT---TTKSAPTTPKEP 552 Query: 899 DSSATCSADEVDEAEGGD----KNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAA 954 + T E K +P+ T +P A + +KP K+ A Sbjct: 553 SPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTP-KEPAP 610 Query: 955 AIP----PIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQP-----------ESDAPQQPG 999 P P K+ E APT P PAP P+ L P E AP P Sbjct: 611 TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 670 Query: 1000 SSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPH 1059 ++ + PAP KE PA + P P P P + + +P Sbjct: 671 AAAPNTPKEPAPTTPKE-------PAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 723 Query: 1060 AP--------------DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKH 1105 P +P++ + P P G T P P P T P P Sbjct: 724 TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT-PKEPAPTTPKEPAPTTPKGTA 782 Query: 1106 PSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSP 1165 P+ L+ + + + P + K P T P P PK+ AP + + +P Sbjct: 783 PTTLKEPAPTTPKKPAPKELAPTT--TKGPTS-TTSDKPAPTTPKETAPTTPKEPAPTTP 839 Query: 1166 RGQAGPPESLGVPTAQEAS 1184 + A PT E S Sbjct: 840 KKPAPTTPETPPPTTSEVS 858 Score = 96.3 bits (238), Expect = 3e-19 Identities = 111/442 (25%), Positives = 142/442 (32%), Gaps = 69/442 (15%) Query: 675 KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734 KE KK AP E A P E + + E A T ++ T Sbjct: 480 KEPAPTAPKKPAPTTPKEPA---PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 536 Query: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-----TPASEATGAP 789 P+P T + T P P T P P P PAPT P T E Sbjct: 537 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 596 Query: 790 TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP-VKSE 848 T PAP +P P P PK ETA P ++ P E+LA T + P E Sbjct: 597 TKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEE 647 Query: 849 CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908 E P E A T + A KE A T AP A + E Sbjct: 648 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTPKE 703 Query: 909 VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968 +P+ + T +P A +P+KP + + P + Sbjct: 704 TAPT---------TPKGTAPTTLKEP-APTTPKKPAPKE--------LAPTTTKEPTSTT 745 Query: 969 REDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025 + APT P AP P P P+ AP P + + PAP K+ PA Sbjct: 746 CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK-------PA 798 Query: 1026 FAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARP 1085 A P TS P P P+E +P P P+ P Sbjct: 799 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------------------P 839 Query: 1086 VLPRPPTISNPPPLISSAKHPS 1107 P P T PPP S P+ Sbjct: 840 KKPAPTTPETPPPTTSEVSTPT 861 Score = 72.0 bits (175), Expect = 7e-12 Identities = 123/544 (22%), Positives = 172/544 (31%), Gaps = 108/544 (19%) Query: 766 PTPPPEDIPAPTEPTPASEATGAPTP-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGE 824 PT PP AP P+ AS+ + T P PP+ V+ EE EE + V E + Sbjct: 110 PTSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHS----VSENQ 164 Query: 825 EQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD-----------------AEAAE 867 E ++ + T + + K+ + K KD EA Sbjct: 165 ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGS 224 Query: 868 ATAEGALKA---------EKKEGGSGRATTAK----SSGAPQDSDSS------------- 901 G K K S + TTAK P +SD+S Sbjct: 225 GLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTV 284 Query: 902 ---ATCSADEVDEAEGGDKNR----------------------LLSPRPSLLTPTGDPRA 936 T + ++ +G +K L P P T T P A Sbjct: 285 ETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-A 343 Query: 937 NASPQKPLDLKQLKQRAAAIP----PIQVTKVHEPPREDA-APTKPAPPAPPPPQNLQPE 991 +P++P K+ A+ P P + P+E A TK AP P P + Sbjct: 344 LTTPKEPTPTTP-KEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 402 Query: 992 SDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPR 1051 AP P ++ PAP K A P A P P T P P P+ Sbjct: 403 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP-----APTTPKKPAPTTPKEPAPTTPK 457 Query: 1052 EVIKASPHAPDPSAFSYAP--PGHPLPLGLHDTA--RPVLPRPPTISNPPPLISSAKHPS 1107 E +P P P+ AP P P P A P P P T P P + P+ Sbjct: 458 EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 517 Query: 1108 VLERQIGAISQGMSVQLHVPYSEHAK-APV-----GPVTMGLPLPMDPKKLAPFSGVKQE 1161 + ++ P K AP P T P P PK+ AP + K Sbjct: 518 TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 577 Query: 1162 QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSIT 1221 +P+ A PT + T P+ P ++A T +T Sbjct: 578 PTTPKEPAPTTPKEPAPTTTKKP------------APTTPKEPAPTTPKETAPTTPKKLT 625 Query: 1222 HGTP 1225 TP Sbjct: 626 PTTP 629 Score = 63.5 bits (153), Expect = 2e-09 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%) Query: 1729 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1788 P P P P T + P P P + + + PT KP T+ E Sbjct: 440 PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 499 Query: 1789 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844 +E +E S T + TT + AP T++ + ++ S P + Sbjct: 500 PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 556 Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1904 +P P + P+ T + T + PT + + ++P PA T Sbjct: 557 TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 612 Query: 1905 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1950 P T L P + P K AP PE P T A Sbjct: 613 PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 672 Query: 1951 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2005 +P + EPA P+ EP P P + T T P P +P PAP Sbjct: 673 APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 730 Query: 2006 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2055 A +E T + KP + +P+G P +P P+ Sbjct: 731 KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 775 Query: 2056 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2110 T KG P L+E PK+P P +L P +P P + ++P Sbjct: 776 TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 829 Query: 2111 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2165 T P T SEV T T+ P ++ P S P L Sbjct: 830 TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 880 Query: 2166 DLRRPPSDLYLPPPDHGAPARGSP 2189 P L P + G P +P Sbjct: 881 SAEPTPKALENSPKEPGVPTTKTP 904 Score = 60.1 bits (144), Expect = 3e-08 Identities = 81/339 (23%), Positives = 121/339 (35%), Gaps = 48/339 (14%) Query: 743 KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP---TPASEATGAPTPP--PAPPS 797 K+ PK PA PT D PAPT P P + APT P PAP + Sbjct: 787 KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTT 846 Query: 798 PSAPPPV-----VPKEEKEEETAAAPPVEE----GEEQKPPAAE----ELAVDTGKAEEP 844 P PPP P KE T P E E P A E E V T K Sbjct: 847 PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 906 Query: 845 VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904 K E T A++ + +D T A K K+ ATT + + ++S T Sbjct: 907 TKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----TATTTEKT-----TESKITA 955 Query: 905 SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964 + +V D +L T T P+ + +K + ++ + P + K Sbjct: 956 TTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT-KKTITTTEIMNK-----PEETAK- 1006 Query: 965 HEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP-PADKEAEKPVFF 1023 P++ A +K P P P + + ++P + PR + P P + P Sbjct: 1007 ---PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN 1063 Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1062 P L T+ P P ++++ +P + D Sbjct: 1064 PTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1096 Score = 57.0 bits (136), Expect = 2e-07 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%) Query: 1732 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1791 P L P TP T + + P P P + + S+P +P P PTTT S+ Sbjct: 342 PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 392 Query: 1792 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1851 +E +E + TT E AP T++ + ++ S P + Sbjct: 393 PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 446 Query: 1852 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1909 +P P + P+ T + T EP+ PT + + ++P +PA T P PA Sbjct: 447 TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 501 Query: 1910 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1969 P EP + P P+ P T K + EPA + +K Sbjct: 502 TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 544 Query: 1970 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2022 + P P + A T K AP +P PAP P + +P T+ Sbjct: 545 APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 602 Query: 2023 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2080 + + + + +P+ + P +P T +K P EEL + E P+ Sbjct: 603 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 662 Query: 2081 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2115 +P P A + P P P + +P P Sbjct: 663 EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 696 Score = 56.2 bits (134), Expect = 4e-07 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%) Query: 1549 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1608 +P TT+EP P + ++ T + K P T P+ P P +P E Sbjct: 397 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 451 Query: 1609 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1662 P PT+ P A P+ AP PT P P + Sbjct: 452 -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 504 Query: 1663 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1721 T E T + T+ + A +P+E S P Sbjct: 505 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 562 Query: 1722 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1780 P P P P T + P P P +++ +P +P P T K T Sbjct: 563 -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 616 Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1836 ++ ++ E+ EK TT E AP P T + + Sbjct: 617 APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 674 Query: 1837 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1896 + PA +P P + P+ T T + + PT L+ + ++ Sbjct: 675 NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 724 Query: 1897 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1949 P +PA P T P T D PT + P + AP + P G A Sbjct: 725 PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 784 Query: 1950 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002 K PA L P ++ S P + T TP + P +P Sbjct: 785 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 841 Query: 2003 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2062 PAP + P S P + +E P + S+P L+ + P Sbjct: 842 PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 886 Query: 2063 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2106 K LE PK+PG AA P LR PE + P Sbjct: 887 KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 936 Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166 + T ++ ++ TQD T L AP + + + Sbjct: 937 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 996 Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2226 + P + P D ++ + +P+P K P P+ T Sbjct: 997 IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 1034 Query: 2227 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2284 + P + + P +M S P TS+ + T + SK E+N K Sbjct: 1035 -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1093 Score = 53.5 bits (127), Expect = 2e-06 Identities = 80/342 (23%), Positives = 120/342 (35%), Gaps = 47/342 (13%) Query: 724 TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAPTEPTPA 782 T +S T P+P T K+T PK PA P P P TPPP T T Sbjct: 807 TKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK 864 Query: 783 SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842 T +P + P SA P E +E K PAA + + T + Sbjct: 865 EPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEMTTTAKD 917 Query: 843 EPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG--------RATTAK 890 + + + E A K A E T E + A + S + TT K Sbjct: 918 KTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 977 Query: 891 SSG-APQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 946 ++ AP+ + + T + E+ E K+R + + + P +A P+KP Sbjct: 978 TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKA---PKKPTST 1034 Query: 947 KQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1006 K+ K +P ++ K PR+ T P P + + +P +P K Sbjct: 1035 KKPK----TMPRVRKPKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKL 1087 Query: 1007 RSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1037 P ++ E E P VF P + LP P Sbjct: 1088 VEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1129 >gi|189181724 proteoglycan 4 isoform D [Homo sapiens] Length = 1270 Score = 106 bits (264), Expect = 3e-22 Identities = 161/707 (22%), Positives = 241/707 (34%), Gaps = 87/707 (12%) Query: 518 EEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGR 577 E KD K K + +K KP V ++ SG DN + + T +++ Sbjct: 65 EVKDNK-KNRTKKKPTPKPPVVDEAG----------SGLDNGDFKVTTPDTSTTQHNKVS 113 Query: 578 RKGRITRSMANEANSEEAITPQQ-SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSA 636 +IT A N ++ P +++ S+ +N+ + +E T K G+ + Sbjct: 114 TSPKITT--AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 171 Query: 637 IARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME---KERNARRKKKKAPAAASEE 693 A+ S + K+ K +L + K E K K+ P E Sbjct: 172 SAKETQSIEKTSAKDLAPTSK-------VLAKPTPKAETTTKGPALTTPKEPTPTTPKEP 224 Query: 694 AAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPP 753 A+ P +E + + E A T ++ T P+P T K+ PK P Sbjct: 225 ASTTP----KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTT--TKEPAPTTPKEP 278 Query: 754 ATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP--PAPPSPSAPPPVVPKEEKE 811 A P P P P EP P + APT P PAP +P P P PKE Sbjct: 279 APTTTKEPAPTTTKSAPT---TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 335 Query: 812 EETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVK-SECTEEAEEGPAKGKDAEAAEATA 870 AP + E P A ++ A T K P E + P+ E A T Sbjct: 336 TTKEPAPTTPK--EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTT 393 Query: 871 EGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGD----KNRLLSPRPS 926 + A K+ + TT + P++ + T E K +P+ Sbjct: 394 KSAPTTTKEPAPT---TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP 450 Query: 927 LLTPTGDPRANASPQKPLDLKQLKQRAAAIP----PIQVTKVHEPPREDAAPTKPAPPAP 982 T +P A + +KP K+ A P P K+ E APT P PAP Sbjct: 451 APTTPKEP-APTTTKKPAPTTP-KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP 508 Query: 983 PPPQNLQP-----------ESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQ 1031 P+ L P E AP P ++ + PAP KE PA + Sbjct: 509 TTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE-------PAPTTPKE 561 Query: 1032 KLPGDPPCWTSGLPFPVPPREVIKASPHAP--------------DPSAFSYAPPGHPLPL 1077 P P P P + + +P P +P++ + P P Sbjct: 562 PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 621 Query: 1078 GLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVG 1137 G T P P P T P P P+ L+ + + + P + K P Sbjct: 622 GTAPTT-PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT--TKGPTS 678 Query: 1138 PVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184 T P P PK+ AP + + +P+ A PT E S Sbjct: 679 -TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 724 Score = 96.3 bits (238), Expect = 3e-19 Identities = 111/442 (25%), Positives = 142/442 (32%), Gaps = 69/442 (15%) Query: 675 KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734 KE KK AP E A P E + + E A T ++ T Sbjct: 346 KEPAPTAPKKPAPTTPKEPA---PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 402 Query: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-----TPASEATGAP 789 P+P T + T P P T P P P PAPT P T E Sbjct: 403 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 462 Query: 790 TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP-VKSE 848 T PAP +P P P PK ETA P ++ P E+LA T + P E Sbjct: 463 TKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEE 513 Query: 849 CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908 E P E A T + A KE A T AP A + E Sbjct: 514 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTPKE 569 Query: 909 VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968 +P+ + T +P A +P+KP + + P + Sbjct: 570 TAPT---------TPKGTAPTTLKEP-APTTPKKPAPKE--------LAPTTTKEPTSTT 611 Query: 969 REDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025 + APT P AP P P P+ AP P + + PAP K+ PA Sbjct: 612 CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK-------PA 664 Query: 1026 FAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARP 1085 A P TS P P P+E +P P P+ P Sbjct: 665 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------------------P 705 Query: 1086 VLPRPPTISNPPPLISSAKHPS 1107 P P T PPP S P+ Sbjct: 706 KKPAPTTPETPPPTTSEVSTPT 727 Score = 63.5 bits (153), Expect = 2e-09 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%) Query: 1729 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1788 P P P P T + P P P + + + PT KP T+ E Sbjct: 306 PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 365 Query: 1789 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844 +E +E S T + TT + AP T++ + ++ S P + Sbjct: 366 PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 422 Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1904 +P P + P+ T + T + PT + + ++P PA T Sbjct: 423 TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 478 Query: 1905 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1950 P T L P + P K AP PE P T A Sbjct: 479 PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 538 Query: 1951 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2005 +P + EPA P+ EP P P + T T P P +P PAP Sbjct: 539 APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 596 Query: 2006 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2055 A +E T + KP + +P+G P +P P+ Sbjct: 597 KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 641 Query: 2056 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2110 T KG P L+E PK+P P +L P +P P + ++P Sbjct: 642 TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 695 Query: 2111 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2165 T P T SEV T T+ P ++ P S P L Sbjct: 696 TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 746 Query: 2166 DLRRPPSDLYLPPPDHGAPARGSP 2189 P L P + G P +P Sbjct: 747 SAEPTPKALENSPKEPGVPTTKTP 770 Score = 60.1 bits (144), Expect = 3e-08 Identities = 81/339 (23%), Positives = 121/339 (35%), Gaps = 48/339 (14%) Query: 743 KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP---TPASEATGAPTPP--PAPPS 797 K+ PK PA PT D PAPT P P + APT P PAP + Sbjct: 653 KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTT 712 Query: 798 PSAPPPV-----VPKEEKEEETAAAPPVEE----GEEQKPPAAE----ELAVDTGKAEEP 844 P PPP P KE T P E E P A E E V T K Sbjct: 713 PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 772 Query: 845 VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904 K E T A++ + +D T A K K+ ATT + + ++S T Sbjct: 773 TKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----TATTTEKT-----TESKITA 821 Query: 905 SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964 + +V D +L T T P+ + +K + ++ + P + K Sbjct: 822 TTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT-KKTITTTEIMNK-----PEETAK- 872 Query: 965 HEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP-PADKEAEKPVFF 1023 P++ A +K P P P + + ++P + PR + P P + P Sbjct: 873 ---PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN 929 Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1062 P L T+ P P ++++ +P + D Sbjct: 930 PTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 962 Score = 57.0 bits (136), Expect = 2e-07 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%) Query: 1732 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1791 P L P TP T + + P P P + + S+P +P P PTTT S+ Sbjct: 208 PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 258 Query: 1792 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1851 +E +E + TT E AP T++ + ++ S P + Sbjct: 259 PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 312 Query: 1852 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1909 +P P + P+ T + T EP+ PT + + ++P +PA T P PA Sbjct: 313 TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 367 Query: 1910 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1969 P EP + P P+ P T K + EPA + +K Sbjct: 368 TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 410 Query: 1970 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2022 + P P + A T K AP +P PAP P + +P T+ Sbjct: 411 APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 468 Query: 2023 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2080 + + + + +P+ + P +P T +K P EEL + E P+ Sbjct: 469 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 528 Query: 2081 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2115 +P P A + P P P + +P P Sbjct: 529 EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 562 Score = 56.2 bits (134), Expect = 4e-07 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%) Query: 1549 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1608 +P TT+EP P + ++ T + K P T P+ P P +P E Sbjct: 263 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 317 Query: 1609 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1662 P PT+ P A P+ AP PT P P + Sbjct: 318 -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 370 Query: 1663 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1721 T E T + T+ + A +P+E S P Sbjct: 371 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 428 Query: 1722 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1780 P P P P T + P P P +++ +P +P P T K T Sbjct: 429 -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 482 Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1836 ++ ++ E+ EK TT E AP P T + + Sbjct: 483 APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 540 Query: 1837 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1896 + PA +P P + P+ T T + + PT L+ + ++ Sbjct: 541 NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 590 Query: 1897 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1949 P +PA P T P T D PT + P + AP + P G A Sbjct: 591 PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 650 Query: 1950 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002 K PA L P ++ S P + T TP + P +P Sbjct: 651 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 707 Query: 2003 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2062 PAP + P S P + +E P + S+P L+ + P Sbjct: 708 PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 752 Query: 2063 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2106 K LE PK+PG AA P LR PE + P Sbjct: 753 KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 802 Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166 + T ++ ++ TQD T L AP + + + Sbjct: 803 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 862 Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2226 + P + P D ++ + +P+P K P P+ T Sbjct: 863 IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 900 Query: 2227 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2284 + P + + P +M S P TS+ + T + SK E+N K Sbjct: 901 -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 959 Score = 53.5 bits (127), Expect = 2e-06 Identities = 80/342 (23%), Positives = 120/342 (35%), Gaps = 47/342 (13%) Query: 724 TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAPTEPTPA 782 T +S T P+P T K+T PK PA P P P TPPP T T Sbjct: 673 TKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK 730 Query: 783 SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842 T +P + P SA P E +E K PAA + + T + Sbjct: 731 EPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEMTTTAKD 783 Query: 843 EPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG--------RATTAK 890 + + + E A K A E T E + A + S + TT K Sbjct: 784 KTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 843 Query: 891 SSG-APQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 946 ++ AP+ + + T + E+ E K+R + + + P +A P+KP Sbjct: 844 TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKA---PKKPTST 900 Query: 947 KQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1006 K+ K +P ++ K PR+ T P P + + +P +P K Sbjct: 901 KKPK----TMPRVRKPKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKL 953 Query: 1007 RSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1037 P ++ E E P VF P + LP P Sbjct: 954 VEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 995 >gi|189181722 proteoglycan 4 isoform C [Homo sapiens] Length = 1311 Score = 106 bits (264), Expect = 3e-22 Identities = 161/707 (22%), Positives = 241/707 (34%), Gaps = 87/707 (12%) Query: 518 EEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGR 577 E KD K K + +K KP V ++ SG DN + + T +++ Sbjct: 106 EVKDNK-KNRTKKKPTPKPPVVDEAG----------SGLDNGDFKVTTPDTSTTQHNKVS 154 Query: 578 RKGRITRSMANEANSEEAITPQQ-SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSA 636 +IT A N ++ P +++ S+ +N+ + +E T K G+ + Sbjct: 155 TSPKITT--AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 212 Query: 637 IARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME---KERNARRKKKKAPAAASEE 693 A+ S + K+ K +L + K E K K+ P E Sbjct: 213 SAKETQSIEKTSAKDLAPTSK-------VLAKPTPKAETTTKGPALTTPKEPTPTTPKEP 265 Query: 694 AAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPP 753 A+ P +E + + E A T ++ T P+P T K+ PK P Sbjct: 266 ASTTP----KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTT--TKEPAPTTPKEP 319 Query: 754 ATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP--PAPPSPSAPPPVVPKEEKE 811 A P P P P EP P + APT P PAP +P P P PKE Sbjct: 320 APTTTKEPAPTTTKSAPT---TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 376 Query: 812 EETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVK-SECTEEAEEGPAKGKDAEAAEATA 870 AP + E P A ++ A T K P E + P+ E A T Sbjct: 377 TTKEPAPTTPK--EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTT 434 Query: 871 EGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGD----KNRLLSPRPS 926 + A K+ + TT + P++ + T E K +P+ Sbjct: 435 KSAPTTTKEPAPT---TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP 491 Query: 927 LLTPTGDPRANASPQKPLDLKQLKQRAAAIP----PIQVTKVHEPPREDAAPTKPAPPAP 982 T +P A + +KP K+ A P P K+ E APT P PAP Sbjct: 492 APTTPKEP-APTTTKKPAPTTP-KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP 549 Query: 983 PPPQNLQP-----------ESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQ 1031 P+ L P E AP P ++ + PAP KE PA + Sbjct: 550 TTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE-------PAPTTPKE 602 Query: 1032 KLPGDPPCWTSGLPFPVPPREVIKASPHAP--------------DPSAFSYAPPGHPLPL 1077 P P P P + + +P P +P++ + P P Sbjct: 603 PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 662 Query: 1078 GLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVG 1137 G T P P P T P P P+ L+ + + + P + K P Sbjct: 663 GTAPTT-PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT--TKGPTS 719 Query: 1138 PVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184 T P P PK+ AP + + +P+ A PT E S Sbjct: 720 -TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 765 Score = 96.3 bits (238), Expect = 3e-19 Identities = 111/442 (25%), Positives = 142/442 (32%), Gaps = 69/442 (15%) Query: 675 KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734 KE KK AP E A P E + + E A T ++ T Sbjct: 387 KEPAPTAPKKPAPTTPKEPA---PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 443 Query: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-----TPASEATGAP 789 P+P T + T P P T P P P PAPT P T E Sbjct: 444 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 503 Query: 790 TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP-VKSE 848 T PAP +P P P PK ETA P ++ P E+LA T + P E Sbjct: 504 TKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEE 554 Query: 849 CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908 E P E A T + A KE A T AP A + E Sbjct: 555 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTPKE 610 Query: 909 VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968 +P+ + T +P A +P+KP + + P + Sbjct: 611 TAPT---------TPKGTAPTTLKEP-APTTPKKPAPKE--------LAPTTTKEPTSTT 652 Query: 969 REDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025 + APT P AP P P P+ AP P + + PAP K+ PA Sbjct: 653 CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK-------PA 705 Query: 1026 FAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARP 1085 A P TS P P P+E +P P P+ P Sbjct: 706 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------------------P 746 Query: 1086 VLPRPPTISNPPPLISSAKHPS 1107 P P T PPP S P+ Sbjct: 747 KKPAPTTPETPPPTTSEVSTPT 768 Score = 63.5 bits (153), Expect = 2e-09 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%) Query: 1729 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1788 P P P P T + P P P + + + PT KP T+ E Sbjct: 347 PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 406 Query: 1789 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844 +E +E S T + TT + AP T++ + ++ S P + Sbjct: 407 PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 463 Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1904 +P P + P+ T + T + PT + + ++P PA T Sbjct: 464 TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 519 Query: 1905 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1950 P T L P + P K AP PE P T A Sbjct: 520 PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 579 Query: 1951 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2005 +P + EPA P+ EP P P + T T P P +P PAP Sbjct: 580 APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 637 Query: 2006 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2055 A +E T + KP + +P+G P +P P+ Sbjct: 638 KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 682 Query: 2056 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2110 T KG P L+E PK+P P +L P +P P + ++P Sbjct: 683 TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 736 Query: 2111 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2165 T P T SEV T T+ P ++ P S P L Sbjct: 737 TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 787 Query: 2166 DLRRPPSDLYLPPPDHGAPARGSP 2189 P L P + G P +P Sbjct: 788 SAEPTPKALENSPKEPGVPTTKTP 811 Score = 60.1 bits (144), Expect = 3e-08 Identities = 81/339 (23%), Positives = 121/339 (35%), Gaps = 48/339 (14%) Query: 743 KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP---TPASEATGAPTPP--PAPPS 797 K+ PK PA PT D PAPT P P + APT P PAP + Sbjct: 694 KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTT 753 Query: 798 PSAPPPV-----VPKEEKEEETAAAPPVEE----GEEQKPPAAE----ELAVDTGKAEEP 844 P PPP P KE T P E E P A E E V T K Sbjct: 754 PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 813 Query: 845 VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904 K E T A++ + +D T A K K+ ATT + + ++S T Sbjct: 814 TKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----TATTTEKT-----TESKITA 862 Query: 905 SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964 + +V D +L T T P+ + +K + ++ + P + K Sbjct: 863 TTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT-KKTITTTEIMNK-----PEETAK- 913 Query: 965 HEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP-PADKEAEKPVFF 1023 P++ A +K P P P + + ++P + PR + P P + P Sbjct: 914 ---PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN 970 Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1062 P L T+ P P ++++ +P + D Sbjct: 971 PTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1003 Score = 57.0 bits (136), Expect = 2e-07 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%) Query: 1732 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1791 P L P TP T + + P P P + + S+P +P P PTTT S+ Sbjct: 249 PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 299 Query: 1792 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1851 +E +E + TT E AP T++ + ++ S P + Sbjct: 300 PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 353 Query: 1852 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1909 +P P + P+ T + T EP+ PT + + ++P +PA T P PA Sbjct: 354 TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 408 Query: 1910 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1969 P EP + P P+ P T K + EPA + +K Sbjct: 409 TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 451 Query: 1970 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2022 + P P + A T K AP +P PAP P + +P T+ Sbjct: 452 APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 509 Query: 2023 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2080 + + + + +P+ + P +P T +K P EEL + E P+ Sbjct: 510 TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 569 Query: 2081 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2115 +P P A + P P P + +P P Sbjct: 570 EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 603 Score = 56.2 bits (134), Expect = 4e-07 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%) Query: 1549 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1608 +P TT+EP P + ++ T + K P T P+ P P +P E Sbjct: 304 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 358 Query: 1609 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1662 P PT+ P A P+ AP PT P P + Sbjct: 359 -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 411 Query: 1663 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1721 T E T + T+ + A +P+E S P Sbjct: 412 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 469 Query: 1722 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1780 P P P P T + P P P +++ +P +P P T K T Sbjct: 470 -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 523 Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1836 ++ ++ E+ EK TT E AP P T + + Sbjct: 524 APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 581 Query: 1837 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1896 + PA +P P + P+ T T + + PT L+ + ++ Sbjct: 582 NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 631 Query: 1897 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1949 P +PA P T P T D PT + P + AP + P G A Sbjct: 632 PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 691 Query: 1950 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002 K PA L P ++ S P + T TP + P +P Sbjct: 692 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 748 Query: 2003 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2062 PAP + P S P + +E P + S+P L+ + P Sbjct: 749 PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 793 Query: 2063 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2106 K LE PK+PG AA P LR PE + P Sbjct: 794 KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 843 Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166 + T ++ ++ TQD T L AP + + + Sbjct: 844 MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 903 Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2226 + P + P D ++ + +P+P K P P+ T Sbjct: 904 IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 941 Query: 2227 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2284 + P + + P +M S P TS+ + T + SK E+N K Sbjct: 942 -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1000 Score = 53.5 bits (127), Expect = 2e-06 Identities = 80/342 (23%), Positives = 120/342 (35%), Gaps = 47/342 (13%) Query: 724 TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAPTEPTPA 782 T +S T P+P T K+T PK PA P P P TPPP T T Sbjct: 714 TKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK 771 Query: 783 SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842 T +P + P SA P E +E K PAA + + T + Sbjct: 772 EPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEMTTTAKD 824 Query: 843 EPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG--------RATTAK 890 + + + E A K A E T E + A + S + TT K Sbjct: 825 KTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 884 Query: 891 SSG-APQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 946 ++ AP+ + + T + E+ E K+R + + + P +A P+KP Sbjct: 885 TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKA---PKKPTST 941 Query: 947 KQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1006 K+ K +P ++ K PR+ T P P + + +P +P K Sbjct: 942 KKPK----TMPRVRKPKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKL 994 Query: 1007 RSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1037 P ++ E E P VF P + LP P Sbjct: 995 VEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1036 >gi|7661892 REST corepressor 1 [Homo sapiens] Length = 482 Score = 105 bits (262), Expect = 5e-22 Identities = 74/285 (25%), Positives = 134/285 (47%), Gaps = 19/285 (6%) Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491 W+ ++K F + F H K F I L K++A V +YY KK S++ R R++ Sbjct: 192 WTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQ- 250 Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDK-----EDLL 546 +++++ + + ++ P+ E KE +KE E P+V+ +K ++ Sbjct: 251 -KREREESEDELEEANGNNPI---DIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRA 306 Query: 547 KEKTDD---TSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAE 603 K K S ED + A A+ + R + N + A+ + Sbjct: 307 KRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGG 366 Query: 604 LASMELNE-----SSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKK 658 + L E ++RWT EE A + + ++GR++ AI+ ++G+K+V Q KNF+ NY++ Sbjct: 367 IEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRR 426 Query: 659 RQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDE 703 R N+DE+LQ+ + + KE +K P + + + P EDE Sbjct: 427 RFNIDEVLQEWEAEHGKEETNGPSNQK-PVKSPDNSIKMPEEEDE 470 >gi|27734799 REST corepressor 2 [Homo sapiens] Length = 523 Score = 103 bits (256), Expect = 3e-21 Identities = 99/393 (25%), Positives = 165/393 (41%), Gaps = 29/393 (7%) Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491 W+ ++K F + F H K F I L K + V YYY KK + S++ R RR G Sbjct: 135 WTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLG 194 Query: 492 KSQQQQQQQQQQQQQ---QQQQPMPRSSQEEK-DEKEKEKEAEKEEEKPEVENDKEDLLK 547 + ++ + ++ + + +P P + E + +++ +V + L+ Sbjct: 195 GRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLR 254 Query: 548 EKTDDTSGEDNDEKEAVASKGR--------KTANSQGRRKGRITRSMANEANS-----EE 594 + G + A G + +SQ R +SM +S E Sbjct: 255 TRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEG 314 Query: 595 AITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYF 654 I P + E A+ + N SRWT +E A + + +G+++ AIA ++G+KT++Q K F+ Sbjct: 315 GIDPLRPPE-ANTKFN--SRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFV 371 Query: 655 NYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNE 714 +Y++R NL+E+LQ+ + + + A ++A A A P + ED+E++ + VS + Sbjct: 372 SYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPA--PALEEDDEVQITSVSTSV 429 Query: 715 EEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQN--GPKPPATLGADGPPPGPPTPPPED 772 V A + S P P T PP G P P PP Sbjct: 430 PRSVPPAPPPPPPPTSL-SQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPP 488 Query: 773 IPAPTEPTPASEATGAPTPPP----APPSPSAP 801 + P P A P PPP AP P AP Sbjct: 489 LIRPALAAPRHSARPGPQPPPTLIGAPLEPPAP 521 Score = 38.5 bits (88), Expect = 0.082 Identities = 41/147 (27%), Positives = 58/147 (39%), Gaps = 34/147 (23%) Query: 937 NASPQKPLDLKQLKQRAAAIPP-------IQVTKVHEP-PREDAAPTKPAPPAPPPPQNL 988 + +P P+ +++ ++ A P +Q+T V PR PAPP PPPP +L Sbjct: 391 DGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRS----VPPAPPPPPPPTSL 446 Query: 989 Q--------PESDAP---QQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDP 1037 P AP +QP +G+ P A + P+ PA AA Sbjct: 447 SQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPR-LAPNQPPPPLIRPALAAPRH------ 499 Query: 1038 PCWTSGLPFPVPPREVIKASPHAPDPS 1064 S P P PP +I A P PS Sbjct: 500 ----SARPGPQPPPTLIGAPLEPPAPS 522 Score = 38.1 bits (87), Expect = 0.11 Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 3/95 (3%) Query: 740 EAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPP-SP 798 EA +D P P P P P +++ + T + PPP PP S Sbjct: 387 EAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSL 446 Query: 799 SAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAA 831 S PPP++ P PP+++G +P A Sbjct: 447 SQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLA 481 Score = 32.3 bits (72), Expect = 5.9 Identities = 20/51 (39%), Positives = 23/51 (45%), Gaps = 11/51 (21%) Query: 1050 PREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPT-ISNPPPL 1099 PR V A P P P++ S PP RP LP PT + PPPL Sbjct: 430 PRSVPPAPPPPPPPTSLSQPPP----------LLRPPLPTAPTLLRQPPPL 470 >gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] Length = 1020 Score = 101 bits (251), Expect = 1e-20 Identities = 171/774 (22%), Positives = 293/774 (37%), Gaps = 112/774 (14%) Query: 293 QWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQS 352 Q E+ F R D+L EA KV N R+ + ++ EY +R+LQ R Sbjct: 288 QSEEWFRVRLDRLSEA--AKV----NTDAMRSAQEEITEY----------RRQLQARTTE 331 Query: 353 RVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINM 412 + + S+ RSE E D S QE +++ DA+ + K+ Sbjct: 332 LEALKSTKDSLERQRSELEDRHQADIASYQEAIQQ------------LDAELRNTKWE-- 377 Query: 413 NGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQH-------PKNFGLIASFLERKTVAE 465 MA ++ Y+D + M + E +R+ P F L + +V+ Sbjct: 378 ---MAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVST 434 Query: 466 CVLY-----YYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEK 520 + + +K+E +V +++ ++++++ ++++ + +EE Sbjct: 435 HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494 Query: 521 DEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKG 580 + E+E ++ EE E + + +KE+ + + EKE S + + + Sbjct: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554 Query: 581 RITRSMANEANSEEAITPQQSAELASMELNESSRWTE-------EEMETAKKGLLEHGRN 633 + EA S E + AE+ S E +S E + E AK + E ++ Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614 Query: 634 WSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKK-----KAPA 688 + V + S + K +E K K ++ A+ +K KA A Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674 Query: 689 AASEEAAFPPVVEDEEME-ASGVSGNEEEMVEEAEATVNNSSDT-ESIPSPHTEAAKDTG 746 + E+A P E + E A E + E+A++ V + + E SP E AK Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734 Query: 747 QNGPKPPATLGADGP--PPGPPTPPPEDIPAPTEPTPASEATGAPTP--PPAPPSPSAPP 802 + K P A P P D+ +P TPA E +P P SP Sbjct: 735 K--AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792 Query: 803 PVVPKEEKE--EETAAAPPVE--EGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPA 858 P++ K +E A AP E + EE K P EE K +EP K E E+ PA Sbjct: 793 VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK---AEEEKAPA 849 Query: 859 KGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKN 918 K E ++ E +A KKE + K + +S E + E DK Sbjct: 850 TPKTEEKKDSKKE---EAPKKEAPKPKVEEKKEPAVEKPKESKV-----EAKKEEAEDKK 901 Query: 919 RLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDA---APT 975 ++ PT + A A + D K P + T+V + +DA P+ Sbjct: 902 KV---------PTPEKEAPAKVEVKEDAK----------PKEKTEVAKKEPDDAKAKEPS 942 Query: 976 KPAPPAPPPPQNLQPESDAPQQPGSSPRGK----------SRSPAPPADKEAEK 1019 KPA P+ + + ++P P+ + S+ P+ P ++AEK Sbjct: 943 KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEK 996 Score = 82.4 bits (202), Expect = 5e-15 Identities = 106/423 (25%), Positives = 167/423 (39%), Gaps = 63/423 (14%) Query: 670 KLKMEKERNARRKKKKAPAAASEEA----AFPPVVEDEEMEASGVSGNEEEMVEEAEATV 725 K+K E++ K +K E+ V E+EE EA G EEE EE EA Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE- 495 Query: 726 NNSSDTESIP-----SPHTEA-------------AKDTGQNGPKPPATLG----ADGP-- 761 +T+S P SP EA AK + K PA + A P Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555 Query: 762 -----PPGPPTPPPEDIPAPTE-------PTPASEATGAPTPPPAPPSPSAPPPVVPKEE 809 PP +P E+ +P E +PA E +P +P +P KEE Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV----KEE 611 Query: 810 KEEETAAAPPVEE-----GEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE 864 + A PV+E E + P A+ + K+ E KS EEA+ P K K Sbjct: 612 AKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS-PEKAKSPV 670 Query: 865 AAEAT----AEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRL 920 AEA A+ +KAE K ++ + + +P+ + S A ++A+ K Sbjct: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730 Query: 921 LSPRPS---LLTPTGDPRANASPQKP--LDLKQLKQRAAAIPPIQVTKVHEPPREDAAPT 975 +P + + P SP+K LD+K + + A + + + P + +P Sbjct: 731 KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR-SPADKFPEKAKSPV 789 Query: 976 KPAPPAPPPPQN-LQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLP 1034 K +P ++ L+ ++ AP++ + + +SP +K E V P AE +K P Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKE-IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP 848 Query: 1035 GDP 1037 P Sbjct: 849 ATP 851 Score = 65.9 bits (159), Expect = 5e-10 Identities = 100/454 (22%), Positives = 163/454 (35%), Gaps = 53/454 (11%) Query: 498 QQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGED 557 ++ + +++ + P S E+ KE+ E K V+ + + + K+ + + Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641 Query: 558 NDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTE 617 E+ K + + + + + EA S E AE S E +S E Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701 Query: 618 EEM-ETAKKGLLEHGRNWSAIARMVG--SKTVSQCKNFYFNYKKRQNLDEILQQHK---L 671 + E AK + E ++ V +KT + K+ K + ++ K + Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761 Query: 672 KMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDT 731 K + + +++ ++PA E A PV E+ + S + E+A+A Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS----PLKEDAKAPEKEIPKK 817 Query: 732 ESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTP 791 E + SP E K +PP + P P T +D + E P EA P P Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKD--SKKEEAPKKEA---PKP 872 Query: 792 P------PAPPSPSAPPPVVPKEEKEEETAAAPP-------VEEGEEQKPPAAEELAV-- 836 PA P KEE E++ P VE E+ KP E+A Sbjct: 873 KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE 932 Query: 837 -DTGKAEEP---------------VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKE 880 D KA+EP K E ++ EE P EA A+ K KE Sbjct: 933 PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKP-------KTEAKAKEDDKTLSKE 985 Query: 881 GGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 914 +A A+ S + DS A E A+G Sbjct: 986 PSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019 Score = 64.7 bits (156), Expect = 1e-09 Identities = 107/575 (18%), Positives = 220/575 (38%), Gaps = 59/575 (10%) Query: 79 SQELHLRPESHSYLPELGKSEME--FIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLT 136 S H++ +S + + KSE E +E + ++ + + E Sbjct: 431 SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGE 490 Query: 137 KDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKK 196 ++ + G+ E SPP+ PE E P + + ++E ++ +K Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550 Query: 197 QQQLEEEAAKPPE---PEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGP--- 250 + +EEA PPE PEK + P E K + E K A + P Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610 Query: 251 ------QVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQ 304 + + P+ + + K +++ K ++ ++ E K ++ Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE--EAKSPEKAKS 668 Query: 305 LMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMS 364 ++A K E+ ++ + AK EK ++++ + E+ +S V + Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSP------EKAKSPVKEEAKSPEKAKSPVKE-------E 715 Query: 365 AARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYK 424 A E S + + E + +++ A P ++ K +++ A + Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA--KSPEKAKTLDVKSPEAKTPAKEE 773 Query: 425 DRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVR 484 R + + E+ K +E+ K S L+ A +K K V+ Sbjct: 774 ARSPADKFPEKAKSPVKEEVKSPEK----AKSPLKEDAKA--------PEKEIPKKEEVK 821 Query: 485 RSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKE- 543 + K Q+ + ++ ++ ++++ P ++E+KD K KE+ +KE KP+VE KE Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSK-KEEAPKKEAPKPKVEEKKEP 880 Query: 544 ----------DLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSE 593 + KE+ +D EKEA A K +++ + K + + ++A ++ Sbjct: 881 AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA-KVEVKEDAKPKEKTEVAKKEPDDAKAK 939 Query: 594 EAITPQQSAELASMELN---ESSRWTEEEMETAKK 625 E P + E A + + E ++ EE+ +T K Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK 974 Score = 52.0 bits (123), Expect = 7e-06 Identities = 79/400 (19%), Positives = 144/400 (36%), Gaps = 38/400 (9%) Query: 473 TKKNENYKSLVRRSYRRRGKSQQQQQ---QQQQQQQQQQQQPMPRSSQEEKDEKEKEKEA 529 TK+ + + KS ++ + + + + ++ + P+ ++ + K KE Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701 Query: 530 EKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANE 589 K EK + +E EK E+ E S ++ A S + K ++ + Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP-EKAKTLD 760 Query: 590 ANSEEAITP--QQSAELASMELNESSRWTEEEM---ETAKKGLLEHGRNWSAIARMVGSK 644 S EA TP +++ A ++ +EE+ E AK L E + K Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK--------APEK 812 Query: 645 TVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNA-------RRKKKKAPAAASEEAAFP 697 + + + K+ + E+ + K +E A +K K A +EA P Sbjct: 813 EIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP 872 Query: 698 PVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEA-AKDTGQNGPKPPATL 756 V E +E E+ + EA + D + +P+P EA AK + KP Sbjct: 873 KVEEKKEPAV------EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT 926 Query: 757 GADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAA 816 P+D A PA + AP + P PK E + + Sbjct: 927 EV-------AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979 Query: 817 APPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEG 856 +E + K AE+ + K +P + ++A +G Sbjct: 980 KTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019 Score = 44.7 bits (104), Expect = 0.001 Identities = 129/565 (22%), Positives = 200/565 (35%), Gaps = 97/565 (17%) Query: 1756 PQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHA 1815 P PFS P P TH+ + E+ + + E++ +T T E Sbjct: 417 PIPFSLPEGL-PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE 475 Query: 1816 PIWRP--GTEQSSGSSGSSGGGGGSS-SRPASHSHAHQHSPISPRTQDALQQRPSVLHNT 1872 + G E+ G + GG + S PA + + + SP ++A + P+ + Sbjct: 476 KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA--KSPAEAKSP 533 Query: 1873 GMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKE 1932 + + E +P SP + A PP P E P E Sbjct: 534 EKEEAKSPAEVKSPE-----KAKSPAKEEAKSPPEAKSPE-----------KEEAKSPAE 577 Query: 1933 APRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKN 1992 V PE+ AK PA+ E A SP++ P PV A++PA+ Sbjct: 578 ---VKSPEK----------AKSPAK---EEAKSPAEAKSPEKAKSPVKEE---AKSPAEA 618 Query: 1993 LAPHHASPDPPA---PPASASDPHREKTQS--KPFSIQELELRSLGYHGSSYSPEGVEP- 2046 +P PA P A P +E+ +S K S ++ E +S S E P Sbjct: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE 678 Query: 2047 --VSPVSSPSLTHDKGLPKHLEELD-----KSHLEGELR--PKQPGPVKLGGEAAHLPHL 2097 SPV + + + +K EE KS ++ E + K PVK E A P Sbjct: 679 KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK---EEAKTPEK 735 Query: 2098 RPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSF 2157 P + + SP +P ++ TL E T P + A PA F Sbjct: 736 AKSPVKEEAKSPEKAKSP-----EKAKTLDVKSPEAKT-------PAKEEARSPAD--KF 781 Query: 2158 P-GASCPVLDLRRPPSDLYLP-PPDHGAPARGSPHSE----GGKRSPEPNKTSVLGGGED 2211 P A PV + + P P D AP + P E K +P + V + Sbjct: 782 PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK 841 Query: 2212 GIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTE-PSRMGSKSPGNTSQPPAFFSKLTESN 2270 E +P TE +D ++ E P + K + PA + + Sbjct: 842 AEEEKAPATPKTEE-----------KKDSKKEEAPKKEAPKPKVEEKKEPA----VEKPK 886 Query: 2271 SAMVKSKKQEI--NKKLNTHNRNEP 2293 + V++KK+E KK+ T + P Sbjct: 887 ESKVEAKKEEAEDKKKVPTPEKEAP 911 Score = 40.4 bits (93), Expect = 0.022 Identities = 62/265 (23%), Positives = 112/265 (42%), Gaps = 17/265 (6%) Query: 93 PELGKSEMEFIESKRPRLELLPDPLLRPSPLLATG-QPAGSEDLTKDRSLT-GKLEPVSP 150 PE KS ++ E+K P P SP A + A + D+ + T K E SP Sbjct: 719 PEKAKSPVKE-EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777 Query: 151 ----PSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAK 206 P + + E+ P +K L ++ ++EI E+ S +K++++ E + + Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837 Query: 207 PP---EPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDT 263 PP E EK + P E K S +E KK ++ E P VE P ++ Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSK----KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893 Query: 264 RQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWE--KKVERIENNPR 321 ++ E+ K K+ + + A+ + + + ++ +A E K E+ E P Sbjct: 894 KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE 953 Query: 322 RR-AKESKVREYYEKQFPEIRKQRE 345 ++ KE K ++ EK E + + + Sbjct: 954 KKDTKEEKAKKPEEKPKTEAKAKED 978 Score = 33.9 bits (76), Expect = 2.0 Identities = 43/206 (20%), Positives = 83/206 (40%), Gaps = 14/206 (6%) Query: 54 SPGSIIQPQRRRPSLLSEFQ-PGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLEL 112 SP + P++ + E + P +S E ++ S + E KS E +K P E Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPE-----KAKSPVKEEAKSPAE---AKSPVKEE 625 Query: 113 LPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEEL 172 P SP A P E + +++ + + E P + + E P +K + Sbjct: 626 AKSPAEVKSPEKAKS-PTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684 Query: 173 IQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPV---SPPPIESKHRSLVQI 229 ++ + V+++ +K + ++EEA P + + PV + P ++K + Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744 Query: 230 IYDENRKKAEAAHRILEGLGPQVELP 255 E K E A + L+ P+ + P Sbjct: 745 KSPEKAKSPEKA-KTLDVKSPEAKTP 769 >gi|209977084 REST corepressor 3 isoform c [Homo sapiens] Length = 449 Score = 100 bits (250), Expect = 1e-20 Identities = 86/311 (27%), Positives = 136/311 (43%), Gaps = 41/311 (13%) Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491 W+ ++K F + F H K+F I L KT+A V YYY KK + SL+ R R Sbjct: 147 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 203 Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545 K + Q ++ PM + + +KE +KE E+ V+ K L Sbjct: 204 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 260 Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592 + K G +++ VA S AN+ R+ + R + N Sbjct: 261 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 320 Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647 A+ + + + ES+ RWT EE A +G+ ++G+++ AIA ++G+KTV Sbjct: 321 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 380 Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707 Q KNF+ NY++R NL+E+LQ+ E E+ + A E + V Sbjct: 381 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 429 Query: 708 SGVSGNEEEMV 718 SG S +EEE V Sbjct: 430 SGKSTDEEEEV 440 >gi|112382224 atrophin-1 like protein isoform a [Homo sapiens] Length = 1566 Score = 100 bits (250), Expect = 1e-20 Identities = 193/820 (23%), Positives = 279/820 (34%), Gaps = 154/820 (18%) Query: 432 WSEQEKETFREKFMQHPKNFGLIAS-FLERKTVAECVLYYYLTKKN-ENYKSLVRRSYRR 489 W+E E + F + Q+ KNF I L K E + +YY KK E S R +RR Sbjct: 396 WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRR 455 Query: 490 RGKSQQQQQQQQQQQQQQQQQP-------MPRSSQEEKDEKEKEKEAE------------ 530 + ++ + + +P + +S+++ D ++ E+E + Sbjct: 456 QAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTS 515 Query: 531 ----------------------KEEEKPEVENDKEDL------LKEKTDDTSGEDNDEKE 562 K E P +E + +KE+ D SG+ + Sbjct: 516 KDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTR 575 Query: 563 AVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAELASMELNESSRWTEEEME 621 S+G + GR+K + + N + + + S AS N+S + E Sbjct: 576 R--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDS------KAE 627 Query: 622 TAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARR 681 T KK A+ V + S K+ KRQ + K+ + E R Sbjct: 628 TVKKS-----------AKKVKEEASSPLKS-----NKRQ-------REKVASDTEEADRT 664 Query: 682 KKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPH-TE 740 KK P E E ++ V N+E + + +N S + SIPSP E Sbjct: 665 SSKKTKTQEISRPNSPSEGEGESSDSRSV--NDEGSSDPKDIDQDNRSTSPSIPSPQDNE 722 Query: 741 AAKDTGQNGP----KPPATLGADGPPPGPPTPPPEDIPAPTE-PTPASEAT---GAPTPP 792 + D+ +PPA G P P + PP PT PTP++ A G+PT Sbjct: 723 SDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTAS 782 Query: 793 PAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 850 AP P AP VP ++ A P P P L TG A +P Sbjct: 783 QAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP----SA 838 Query: 851 EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 910 + P G+ + G L + G PQ S Sbjct: 839 PSHAQPPLHGQGPPGPHSLQAGPL--------------LQHPGPPQPFGLPPQASQ---G 881 Query: 911 EAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRE 970 +A G P SL P A S Q P R +PP + H P Sbjct: 882 QAPLGTSPAAAYPHTSLQLPASQ-SALQSQQPP--------REQPLPPAPLAMPHIKP-- 930 Query: 971 DAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEA 1030 PT P P P P + P P G SP + + PP A KP+ + Sbjct: 931 --PPTTPIPQLPAPQAHKHP----PHLSGPSPFSMNANLPPP---PALKPLSSLSTHHPP 981 Query: 1031 QKLPGDPPCWTSGLPFPVPPREV--IKASPHAPDPSAFSYAPPGHPLPLGLHDTA-RPVL 1087 P P P P + + S + P P P HP P GLH A +P Sbjct: 982 SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPP------PASHP-PTGLHQVAPQPPF 1034 Query: 1088 PRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMG--LPL 1145 + P + PP I+ PS G G S Q P A A G + G PL Sbjct: 1035 AQHPFVPGGPPPITPPTCPSTSTPPAG---PGTSAQ---PPCSGAAASGGSIAGGSSCPL 1088 Query: 1146 P-MDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184 P + K+ A + E P ++ PE V T AS Sbjct: 1089 PTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHAS 1128 Score = 88.2 bits (217), Expect = 9e-17 Identities = 163/733 (22%), Positives = 260/733 (35%), Gaps = 167/733 (22%) Query: 615 WTEEEMETAKKGLLEHGRNWSAIAR-MVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKM 673 WTE+E++ KGL ++G+N+ I + ++ +K + FY+ +KK + + + Sbjct: 396 WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTP--EAASSRAHRRH 453 Query: 674 EKERNARRKKKKAPAAASEEAAFPPV---------------VEDEEMEASGVS------- 711 ++ RR K + + + PP ED E E G + Sbjct: 454 RRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTT 513 Query: 712 -------GNEEEMVEEAEATVNNSSDTESIP------------SPHTEAAKDTGQNGPKP 752 G E ++ + ++ E P P E +D G +G Sbjct: 514 TSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKE--EDDGLSGKHS 571 Query: 753 PATLGADG--------------PPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSP 798 T + G P G +P EDI + +P++ +T S Sbjct: 572 MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTS---------SN 622 Query: 799 SAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAE---- 854 + V K K+ + A+ P++ + Q+ E++A DT +A+ S+ T+ E Sbjct: 623 DSKAETVKKSAKKVKEEASSPLKSNKRQR----EKVASDTEEADR-TSSKKTKTQEISRP 677 Query: 855 EGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 914 P++G+ + + ++ K+ +T+ S +PQD++S + SA + Sbjct: 678 NSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQ------ 731 Query: 915 GDKNRLLSPRPSLLTPTGDPRA--NASPQKP-LDLKQLKQRAAAIPPIQVTKVHEPPRED 971 L + P+L PTG A +A P P L A A+PP + P + Sbjct: 732 ---QMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQP 788 Query: 972 AAPTKPA---------------PPAPPPPQNLQPESDAPQQPGSSPRGKSRSPA------ 1010 APT P PP+P PP + P P QP + G+ +P+ Sbjct: 789 QAPTAPVPHTHIQQAPALHPQRPPSPHPPPH--PSPHPPLQPLTGSAGQPSAPSHAQPPL 846 Query: 1011 ----PPADKEAE-----------KPVFFPAFAAEAQKLPGDPPCWT------------SG 1043 PP + +P P A++ Q G P S Sbjct: 847 HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSA 906 Query: 1044 LPFPVPPREVIKASPHAPDPSAFSY--APPGHPLPLGLHDTARPVLPRPPTISNPPPLIS 1101 L PPRE P P P A + PP P+P A PP +S P P Sbjct: 907 LQSQQPPRE----QPLPPAPLAMPHIKPPPTTPIP---QLPAPQAHKHPPHLSGPSPFSM 959 Query: 1102 SAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQE 1161 +A P A+ S+ H P S H P+ + PLP P + P + + Sbjct: 960 NANLPPP-----PALKPLSSLSTHHPPSAH-PPPLQLMPQSQPLPSSPAQ--PPGLTQSQ 1011 Query: 1162 QLSPRGQAGPPESL-----GVPTAQEASVLRGTALGSVPGGSITKGIP-----STRVPSD 1211 L P + PP L P AQ V G + P T P S + P Sbjct: 1012 NLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCS 1071 Query: 1212 SAITYRGSITHGT 1224 A GSI G+ Sbjct: 1072 GAAASGGSIAGGS 1084 Score = 47.8 bits (112), Expect = 1e-04 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%) Query: 1786 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1845 ERER++++E++R+RERE+ E + SS G S P Sbjct: 1181 EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 1223 Query: 1846 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1904 H P P + +T + T E + P V+ T+ + P P Sbjct: 1224 GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 1281 Query: 1905 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1961 P A H P L V PT+ E L +E R R R F KPP L Sbjct: 1282 DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 1338 Query: 1962 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2018 PA++P + +PP +G PH AS P P Q Sbjct: 1339 PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 1385 Query: 2019 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2078 +P L + H + +P++ + ++T P H + SH+ L Sbjct: 1386 LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 1437 Query: 2079 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2136 Q P+ G P + PL ++ P L P G L Q H E++ Sbjct: 1438 LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 1492 Query: 2137 D-YTRHHPQQLSAPLPAPL 2154 + +P+ L +P P+ Sbjct: 1493 PVFGTPYPRDLPGAIPPPM 1511 Score = 43.5 bits (101), Expect = 0.003 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%) Query: 1389 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1447 K +A PLK K E + + +EA R+ + + + P P EG + Sbjct: 637 KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 692 Query: 1448 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1506 + D G+S D RS T P + P D +D+ + + ++ L+++P Sbjct: 693 VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 741 Query: 1507 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1560 + G AP P+L P +P G+P A P P P P Sbjct: 742 QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 800 Query: 1561 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1594 Q +L + + LT + + + H+ P H Sbjct: 801 QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 860 Query: 1595 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1644 HP P P+ + G + A+ TS+ A + PR Sbjct: 861 PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 920 Query: 1645 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1689 H+ P PT P H +PP+L P + ++S HH Sbjct: 921 APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 979 Query: 1690 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1749 +A ++ P SS A P G L+Q +LP PP P T + ++ Sbjct: 980 PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 1028 Query: 1750 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1809 A PQP ++H P PGGP +T PT S+S Sbjct: 1029 A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 1056 Query: 1810 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1853 P PGT SG++ GG G SS P A + P Sbjct: 1057 -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 1111 Query: 1854 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1913 SP + + PS H + ++ + R+ P+ G Sbjct: 1112 RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 1156 Query: 1914 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1958 L +E +EA + AR ER R + A A A Sbjct: 1157 SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 1214 Query: 1959 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2003 G L EP P VPP G T A RT ++ PH SP P Sbjct: 1215 GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 1274 Query: 2004 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2044 P + +DP RE + + + I+E ELR G P + Sbjct: 1275 YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 1334 Query: 2045 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2085 +P+ P ++P +LT H L L++ L +LRP+ P Sbjct: 1335 DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 1394 Query: 2086 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2143 +L E H + L + + P H + + L H + + Q HP Sbjct: 1395 RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 1454 Query: 2144 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2173 L+A + +P + P L +PP + Sbjct: 1455 LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 1486 Score = 39.7 bits (91), Expect = 0.037 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%) Query: 1953 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2012 K A+ E ASSP K S R S RT +K S P S S+ Sbjct: 630 KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 683 Query: 2013 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2072 E + S RS+ GSS P+ ++ + +SPS+ P+ E S Sbjct: 684 EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 728 Query: 2073 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2132 + ++ QP ++ + P P S P +P L T V Sbjct: 729 AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 779 Query: 2133 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2192 T + PQ +AP+P P L +RPPS P P P + S Sbjct: 780 --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833 Query: 2193 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2252 G +P + + G G G + + PG + P G+ + + Sbjct: 834 GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 893 Query: 2253 PGNTSQPPAFFSKL 2266 P + Q PA S L Sbjct: 894 PHTSLQLPASQSAL 907 Score = 36.2 bits (82), Expect = 0.41 Identities = 42/185 (22%), Positives = 61/185 (32%), Gaps = 25/185 (13%) Query: 670 KLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSS 729 KL ++E + K++A A EE ++E E E E E A ++S+ Sbjct: 1158 KLAKKREEAIEKAKREAEQKAREERE-----REKEKEKEREREREREREAERAAKASSSA 1212 Query: 730 DTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI-----PAPTEPTPASE 784 + P + PP T+ A P GP TP + P PT + Sbjct: 1213 HEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNH 1272 Query: 785 ATGAPTPPPAP------PSPSAPPPVVPKEEKEEETAAAPPVEE---------GEEQKPP 829 P P P P P + + E E + E G E KPP Sbjct: 1273 PFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPP 1332 Query: 830 AAEEL 834 + L Sbjct: 1333 ELDPL 1337 Score = 33.9 bits (76), Expect = 2.0 Identities = 12/24 (50%), Positives = 19/24 (79%) Query: 1780 TTTSSSERERDRDRERDRDREREK 1803 T ++++++DR+RDRDREREK Sbjct: 2 TADKDKDKDKEKDRDRDRDREREK 25 Score = 32.0 bits (71), Expect = 7.7 Identities = 12/45 (26%), Positives = 28/45 (62%) Query: 491 GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535 G +++++ ++ +++ + R +E + EKEKE+E E+E E+ Sbjct: 1156 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 1200 >gi|112382216 atrophin-1 like protein isoform a [Homo sapiens] Length = 1566 Score = 100 bits (250), Expect = 1e-20 Identities = 193/820 (23%), Positives = 279/820 (34%), Gaps = 154/820 (18%) Query: 432 WSEQEKETFREKFMQHPKNFGLIAS-FLERKTVAECVLYYYLTKKN-ENYKSLVRRSYRR 489 W+E E + F + Q+ KNF I L K E + +YY KK E S R +RR Sbjct: 396 WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRR 455 Query: 490 RGKSQQQQQQQQQQQQQQQQQP-------MPRSSQEEKDEKEKEKEAE------------ 530 + ++ + + +P + +S+++ D ++ E+E + Sbjct: 456 QAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTS 515 Query: 531 ----------------------KEEEKPEVENDKEDL------LKEKTDDTSGEDNDEKE 562 K E P +E + +KE+ D SG+ + Sbjct: 516 KDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTR 575 Query: 563 AVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAELASMELNESSRWTEEEME 621 S+G + GR+K + + N + + + S AS N+S + E Sbjct: 576 R--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDS------KAE 627 Query: 622 TAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARR 681 T KK A+ V + S K+ KRQ + K+ + E R Sbjct: 628 TVKKS-----------AKKVKEEASSPLKS-----NKRQ-------REKVASDTEEADRT 664 Query: 682 KKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPH-TE 740 KK P E E ++ V N+E + + +N S + SIPSP E Sbjct: 665 SSKKTKTQEISRPNSPSEGEGESSDSRSV--NDEGSSDPKDIDQDNRSTSPSIPSPQDNE 722 Query: 741 AAKDTGQNGP----KPPATLGADGPPPGPPTPPPEDIPAPTE-PTPASEAT---GAPTPP 792 + D+ +PPA G P P + PP PT PTP++ A G+PT Sbjct: 723 SDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTAS 782 Query: 793 PAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 850 AP P AP VP ++ A P P P L TG A +P Sbjct: 783 QAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP----SA 838 Query: 851 EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 910 + P G+ + G L + G PQ S Sbjct: 839 PSHAQPPLHGQGPPGPHSLQAGPL--------------LQHPGPPQPFGLPPQASQ---G 881 Query: 911 EAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRE 970 +A G P SL P A S Q P R +PP + H P Sbjct: 882 QAPLGTSPAAAYPHTSLQLPASQ-SALQSQQPP--------REQPLPPAPLAMPHIKP-- 930 Query: 971 DAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEA 1030 PT P P P P + P P G SP + + PP A KP+ + Sbjct: 931 --PPTTPIPQLPAPQAHKHP----PHLSGPSPFSMNANLPPP---PALKPLSSLSTHHPP 981 Query: 1031 QKLPGDPPCWTSGLPFPVPPREV--IKASPHAPDPSAFSYAPPGHPLPLGLHDTA-RPVL 1087 P P P P + + S + P P P HP P GLH A +P Sbjct: 982 SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPP------PASHP-PTGLHQVAPQPPF 1034 Query: 1088 PRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMG--LPL 1145 + P + PP I+ PS G G S Q P A A G + G PL Sbjct: 1035 AQHPFVPGGPPPITPPTCPSTSTPPAG---PGTSAQ---PPCSGAAASGGSIAGGSSCPL 1088 Query: 1146 P-MDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184 P + K+ A + E P ++ PE V T AS Sbjct: 1089 PTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHAS 1128 Score = 88.2 bits (217), Expect = 9e-17 Identities = 163/733 (22%), Positives = 260/733 (35%), Gaps = 167/733 (22%) Query: 615 WTEEEMETAKKGLLEHGRNWSAIAR-MVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKM 673 WTE+E++ KGL ++G+N+ I + ++ +K + FY+ +KK + + + Sbjct: 396 WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTP--EAASSRAHRRH 453 Query: 674 EKERNARRKKKKAPAAASEEAAFPPV---------------VEDEEMEASGVS------- 711 ++ RR K + + + PP ED E E G + Sbjct: 454 RRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTT 513 Query: 712 -------GNEEEMVEEAEATVNNSSDTESIP------------SPHTEAAKDTGQNGPKP 752 G E ++ + ++ E P P E +D G +G Sbjct: 514 TSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKE--EDDGLSGKHS 571 Query: 753 PATLGADG--------------PPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSP 798 T + G P G +P EDI + +P++ +T S Sbjct: 572 MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTS---------SN 622 Query: 799 SAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAE---- 854 + V K K+ + A+ P++ + Q+ E++A DT +A+ S+ T+ E Sbjct: 623 DSKAETVKKSAKKVKEEASSPLKSNKRQR----EKVASDTEEADR-TSSKKTKTQEISRP 677 Query: 855 EGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 914 P++G+ + + ++ K+ +T+ S +PQD++S + SA + Sbjct: 678 NSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQ------ 731 Query: 915 GDKNRLLSPRPSLLTPTGDPRA--NASPQKP-LDLKQLKQRAAAIPPIQVTKVHEPPRED 971 L + P+L PTG A +A P P L A A+PP + P + Sbjct: 732 ---QMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQP 788 Query: 972 AAPTKPA---------------PPAPPPPQNLQPESDAPQQPGSSPRGKSRSPA------ 1010 APT P PP+P PP + P P QP + G+ +P+ Sbjct: 789 QAPTAPVPHTHIQQAPALHPQRPPSPHPPPH--PSPHPPLQPLTGSAGQPSAPSHAQPPL 846 Query: 1011 ----PPADKEAE-----------KPVFFPAFAAEAQKLPGDPPCWT------------SG 1043 PP + +P P A++ Q G P S Sbjct: 847 HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSA 906 Query: 1044 LPFPVPPREVIKASPHAPDPSAFSY--APPGHPLPLGLHDTARPVLPRPPTISNPPPLIS 1101 L PPRE P P P A + PP P+P A PP +S P P Sbjct: 907 LQSQQPPRE----QPLPPAPLAMPHIKPPPTTPIP---QLPAPQAHKHPPHLSGPSPFSM 959 Query: 1102 SAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQE 1161 +A P A+ S+ H P S H P+ + PLP P + P + + Sbjct: 960 NANLPPP-----PALKPLSSLSTHHPPSAH-PPPLQLMPQSQPLPSSPAQ--PPGLTQSQ 1011 Query: 1162 QLSPRGQAGPPESL-----GVPTAQEASVLRGTALGSVPGGSITKGIP-----STRVPSD 1211 L P + PP L P AQ V G + P T P S + P Sbjct: 1012 NLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCS 1071 Query: 1212 SAITYRGSITHGT 1224 A GSI G+ Sbjct: 1072 GAAASGGSIAGGS 1084 Score = 47.8 bits (112), Expect = 1e-04 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%) Query: 1786 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1845 ERER++++E++R+RERE+ E + SS G S P Sbjct: 1181 EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 1223 Query: 1846 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1904 H P P + +T + T E + P V+ T+ + P P Sbjct: 1224 GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 1281 Query: 1905 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1961 P A H P L V PT+ E L +E R R R F KPP L Sbjct: 1282 DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 1338 Query: 1962 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2018 PA++P + +PP +G PH AS P P Q Sbjct: 1339 PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 1385 Query: 2019 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2078 +P L + H + +P++ + ++T P H + SH+ L Sbjct: 1386 LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 1437 Query: 2079 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2136 Q P+ G P + PL ++ P L P G L Q H E++ Sbjct: 1438 LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 1492 Query: 2137 D-YTRHHPQQLSAPLPAPL 2154 + +P+ L +P P+ Sbjct: 1493 PVFGTPYPRDLPGAIPPPM 1511 Score = 43.5 bits (101), Expect = 0.003 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%) Query: 1389 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1447 K +A PLK K E + + +EA R+ + + + P P EG + Sbjct: 637 KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 692 Query: 1448 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1506 + D G+S D RS T P + P D +D+ + + ++ L+++P Sbjct: 693 VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 741 Query: 1507 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1560 + G AP P+L P +P G+P A P P P P Sbjct: 742 QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 800 Query: 1561 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1594 Q +L + + LT + + + H+ P H Sbjct: 801 QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 860 Query: 1595 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1644 HP P P+ + G + A+ TS+ A + PR Sbjct: 861 PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 920 Query: 1645 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1689 H+ P PT P H +PP+L P + ++S HH Sbjct: 921 APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 979 Query: 1690 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1749 +A ++ P SS A P G L+Q +LP PP P T + ++ Sbjct: 980 PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 1028 Query: 1750 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1809 A PQP ++H P PGGP +T PT S+S Sbjct: 1029 A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 1056 Query: 1810 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1853 P PGT SG++ GG G SS P A + P Sbjct: 1057 -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 1111 Query: 1854 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1913 SP + + PS H + ++ + R+ P+ G Sbjct: 1112 RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 1156 Query: 1914 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1958 L +E +EA + AR ER R + A A A Sbjct: 1157 SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 1214 Query: 1959 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2003 G L EP P VPP G T A RT ++ PH SP P Sbjct: 1215 GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 1274 Query: 2004 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2044 P + +DP RE + + + I+E ELR G P + Sbjct: 1275 YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 1334 Query: 2045 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2085 +P+ P ++P +LT H L L++ L +LRP+ P Sbjct: 1335 DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 1394 Query: 2086 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2143 +L E H + L + + P H + + L H + + Q HP Sbjct: 1395 RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 1454 Query: 2144 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2173 L+A + +P + P L +PP + Sbjct: 1455 LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 1486 Score = 39.7 bits (91), Expect = 0.037 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%) Query: 1953 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2012 K A+ E ASSP K S R S RT +K S P S S+ Sbjct: 630 KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 683 Query: 2013 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2072 E + S RS+ GSS P+ ++ + +SPS+ P+ E S Sbjct: 684 EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 728 Query: 2073 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2132 + ++ QP ++ + P P S P +P L T V Sbjct: 729 AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 779 Query: 2133 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2192 T + PQ +AP+P P L +RPPS P P P + S Sbjct: 780 --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833 Query: 2193 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2252 G +P + + G G G + + PG + P G+ + + Sbjct: 834 GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 893 Query: 2253 PGNTSQPPAFFSKL 2266 P + Q PA S L Sbjct: 894 PHTSLQLPASQSAL 907 Score = 36.2 bits (82), Expect = 0.41 Identities = 42/185 (22%), Positives = 61/185 (32%), Gaps = 25/185 (13%) Query: 670 KLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSS 729 KL ++E + K++A A EE ++E E E E E A ++S+ Sbjct: 1158 KLAKKREEAIEKAKREAEQKAREERE-----REKEKEKEREREREREREAERAAKASSSA 1212 Query: 730 DTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI-----PAPTEPTPASE 784 + P + PP T+ A P GP TP + P PT + Sbjct: 1213 HEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNH 1272 Query: 785 ATGAPTPPPAP------PSPSAPPPVVPKEEKEEETAAAPPVEE---------GEEQKPP 829 P P P P P + + E E + E G E KPP Sbjct: 1273 PFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPP 1332 Query: 830 AAEEL 834 + L Sbjct: 1333 ELDPL 1337 Score = 33.9 bits (76), Expect = 2.0 Identities = 12/24 (50%), Positives = 19/24 (79%) Query: 1780 TTTSSSERERDRDRERDRDREREK 1803 T ++++++DR+RDRDREREK Sbjct: 2 TADKDKDKDKEKDRDRDRDREREK 25 Score = 32.0 bits (71), Expect = 7.7 Identities = 12/45 (26%), Positives = 28/45 (62%) Query: 491 GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535 G +++++ ++ +++ + R +E + EKEKE+E E+E E+ Sbjct: 1156 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 1200 >gi|163965366 nascent polypeptide-associated complex alpha subunit isoform a [Homo sapiens] Length = 2078 Score = 96.3 bits (238), Expect = 3e-19 Identities = 285/1292 (22%), Positives = 414/1292 (32%), Gaps = 243/1292 (18%) Query: 721 AEATVNNSSDTESIPSPHTEAAKDTG-QNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP 779 A T +S + SP E +N P TL P P P P Sbjct: 659 APTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTT------LPLVPTASENCPVAP 712 Query: 780 TPASEATG------APTPPPAPPSPSAPPPVVPKEEKE----EETAAAPPVEEGEEQKP- 828 +P + AP P + PSPS PP P K+ T+A PV ++ P Sbjct: 713 SPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPT 772 Query: 829 ------PAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGG 882 A T A+ P + + K A T G L Sbjct: 773 EDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNL-------- 824 Query: 883 SGRATTAKSSGAPQDS-------DSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPR 935 S + ++S P++S DS AT + +G +P PS +TP Sbjct: 825 SSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKG-------APTPSAVTPLSPKG 877 Query: 936 ANASPQKP-----LDLKQLKQRAAAIPPIQV----------TKVHEPPREDAAPTKPAPP 980 P++ ++L K+ A P Q K P P P+P Sbjct: 878 VTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPK 937 Query: 981 APPPPQNLQPESD-----------APQQPGSSPRGKSRSPAPPADKEAEKPVFFPAF--- 1026 P P P S AP P ++P PA P+ K A P PA Sbjct: 938 GAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP---PAATPP 994 Query: 1027 ------AAEAQKLPGDPPCWTSGLPFPVP---PREVIKASPHAPDPSAFSYAPPGHPLPL 1077 A + K PP T P P P ++P A P + +P PLP Sbjct: 995 SPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK 1054 Query: 1078 GLHDTARPVLPRPPTISNPPPLISSAKHPSVL-ERQIGAISQGMSVQLHVPYSEHAKAPV 1136 G T LP P P L + P+ G + +P + +P Sbjct: 1055 GAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPK 1114 Query: 1137 GPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPG 1196 G GL P P K AP + SP+G P G PT A+ S G Sbjct: 1115 G----GLATP--PHKGAPTTPAATPP-SPKGGLATPPPKGAPTTPAATP------PSPKG 1161 Query: 1197 GSIT---KGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDS 1253 G T KG P+T P+ + + +G + +P KG T PS Sbjct: 1162 GLATPPPKGAPTT--PAATPPSPKGGLATPSP-----KGAPT-TPAATPPS--------- 1204 Query: 1254 LPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAI 1313 PKG + KG + + T S + G ++ P P T +G Sbjct: 1205 -PKGGLATPSPKGAPTT----PAATPPSPKGGLATPSPKGAPTTPAATPPSPKG------ 1253 Query: 1314 SSASIEGLMGRAIPPERHSP-HHLKEQHHIRGSIT----QGIPRSYVEAQEDYLRREAKL 1368 G A PP + +P ++G + +G P V Sbjct: 1254 ---------GPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAV------------- 1291 Query: 1369 LKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGR-SIHEIPREELRHT 1427 PP P T K P P+ +G T G + + + T Sbjct: 1292 -----VTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGT 1346 Query: 1428 PELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGR-----------TFP 1476 P LP A P +G T + + T + T S K SP R T P Sbjct: 1347 PTLP-ATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSP 1405 Query: 1477 PVHPLD-VMADARALER--------------ACYEESLKSRPGTASSSGGSI---ARGAP 1518 V PL A A + R A SLK P T++ GG ++G P Sbjct: 1406 AVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDP 1465 Query: 1519 VI----------------VPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTRE----PTP 1558 + V P+++P T GAP LP P + +E P+ Sbjct: 1466 TLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAP---TLPAVIPSSPKEVPATPSS 1522 Query: 1559 RLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSH 1618 R + +++ S+ T P+E P TVP P P + + Sbjct: 1523 RRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPK--EAPATPSSKEAS 1580 Query: 1619 IPLAFDPTSI-----PRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENR 1673 P A P++ P+ + + A P+ PT P + PP +G P T A + Sbjct: 1581 SPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEA---PTPPAVTPPSPEKG-PATPAPKGT 1636 Query: 1674 QTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVP---H 1730 T + +T + + + + M G + ++S L GP + ++ P Sbjct: 1637 PT--SPPVTPSSLKDSPTSPASVTCKM--GATVPQASKGLPAKKGPTALKEVLVAPAPES 1692 Query: 1731 LPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERD 1790 P++ PT P T P P P + S PLS P L P SS+ + Sbjct: 1693 TPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLL-PVQKDSSKTAKG 1751 Query: 1791 RDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQ 1850 +D K L + P+ E+ S + S P S A Sbjct: 1752 KDASHS-----PKGPLAPPESKASTPLTAAAFEKVL-PKPESASVSAAPSPPVSLPLAPS 1805 Query: 1851 HSPISPRTQDALQQRPSVLHNTGMKGIITAVE 1882 P P Q L P ++ + K + A E Sbjct: 1806 PVPTLPPKQQFLPSSPGLVLESPSKPLAPADE 1837 Score = 92.0 bits (227), Expect = 6e-18 Identities = 212/937 (22%), Positives = 303/937 (32%), Gaps = 195/937 (20%) Query: 750 PKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPA-PPSPSAPPPVVPKE 808 P P + A P G PT P +P+P GAPTPP A PPSP P + Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK 1100 Query: 809 EKEEETAAAPPVEEGEEQKP--------PAAEELAVDTGKAEEPVKSECTEEAEEGPA-K 859 AA PP +G P PAA + G A P K T A P+ K Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1160 Query: 860 G-------KDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEA 912 G K A A + K A T ++ P AT S Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220 Query: 913 EG----GDKNRLLSPRP--SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHE 966 K L +P P + TP P + K AA PP + Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLAT 1280 Query: 967 PPREDAA-PTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025 PP + A P PP+P P AP P ++P SP P K A P PA Sbjct: 1281 PPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTP---PA 1337 Query: 1026 FAAEAQK----LPG------------------DPPCWT---SGLPFPVPPREVIKASPHA 1060 + K LP PP T G P PP K P Sbjct: 1338 VTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSP--KRGPAI 1395 Query: 1061 PDPSAFSYAPPGHPL--------PLGLHDTARP-------------VLPRPPTISNP--- 1096 P P +P PL P+ A P L + P S P Sbjct: 1396 PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGG 1455 Query: 1097 PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLP-----LPMDPKK 1151 P SS P++ + + + + S KAP P MG P +P PK+ Sbjct: 1456 PATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKE 1515 Query: 1152 LAPFSGVKQEQLSPR---------GQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKG 1202 + +++ ++P P E+L +P A + T ++P Sbjct: 1516 VPATPSSRRDPIAPTATLLSKKTPATLAPKEAL-IPPAMTVPSPKKTP--AIPTPKEAPA 1572 Query: 1203 IPSTR----VPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGH 1258 PS++ P+ + TY+G+ +P ++L +T +++P+ Sbjct: 1573 TPSSKEASSPPAVTPSTYKGA---PSPKELLIPPAVTSPSPKEAPT-------------- 1615 Query: 1259 VIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASI 1318 +VT S E G ++ P +P T ++ S AS+ Sbjct: 1616 ---------------PPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLK---DSPTSPASV 1657 Query: 1319 EGLMGRAIP------PERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKRE 1372 MG +P P + P LKE + P S R+ + K Sbjct: 1658 TCKMGATVPQASKGLPAKKGPTALKE------VLVAPAPES-TPIITAPTRKGPQTKKSS 1710 Query: 1373 GTPPP--PPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPEL 1430 T PP P PS + P L P + T K ++ H+P+ Sbjct: 1711 ATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAK----------GKDASHSPKG 1760 Query: 1431 PLAP------RPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVM 1484 PLAP PL + + P S S + L SP T PP Sbjct: 1761 PLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSL-PLAPSPVPTLPP------- 1812 Query: 1485 ADARALERACYEESLKSRPGTASSSGGSIARGA------PVIVPEL---GKPRQSPLTYE 1535 ++ L S PG S A P+I PE G P QS L Sbjct: 1813 ----------KQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLV-- 1860 Query: 1536 DHGAPFAGHLPRGSPVTTREPTPRLQEGSLSSSKASQ 1572 + P + +P +P + ++P + +GS + S + + Sbjct: 1861 NMPTPKSAGIPVPTP-SAKQPVTKNNKGSGTESDSDE 1896 Score = 75.9 bits (185), Expect = 5e-13 Identities = 100/408 (24%), Positives = 146/408 (35%), Gaps = 65/408 (15%) Query: 684 KKAPAAASEEAA--FPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTE--------- 732 KKAPA + A P V+ E + + + ++ + Sbjct: 1491 KKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIP 1550 Query: 733 ---SIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT-----PPPEDI---PAPTEPTP 781 ++PSP A T + P P++ A PP P+ P P+++ PA T P+P Sbjct: 1551 PAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSP 1610 Query: 782 ASEATGAPTPPP-APPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840 APTPP PPSP P A P +G PP D+ Sbjct: 1611 KE----APTPPAVTPPSPEKGP--------------ATPAPKGTPTSPPVTPSSLKDSPT 1652 Query: 841 AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 900 + V + + +KG A+ + L A E S TA + PQ S Sbjct: 1653 SPASVTCKMGATVPQA-SKGLPAKKGPTALKEVLVAPAPE--STPIITAPTRKGPQTKKS 1709 Query: 901 SATCSADEVD-EAEGGDKNRLLSPRPSLLTPTGDPR--------ANASPQKPLDLKQLKQ 951 SAT D A+ G K L + P+ L P A+ SP+ PL + K Sbjct: 1710 SATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESK- 1768 Query: 952 RAAAIPPIQVTKVHEPPREDAAPTKPAPP-----APPPPQNLQPESD-APQQPGSSPRGK 1005 + + KV P + P+PP AP P L P+ P PG Sbjct: 1769 ASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESP 1828 Query: 1006 SRSPAPPADKEAEKPVFFPAFAAEA----QKLPGDPPCWTSGLPFPVP 1049 S+ P PAD++ P+ P + L P ++G+P P P Sbjct: 1829 SK-PLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTP 1875 Score = 65.9 bits (159), Expect = 5e-10 Identities = 374/1670 (22%), Positives = 528/1670 (31%), Gaps = 307/1670 (18%) Query: 728 SSDTESIPSPHTEAAKDTGQNGPKP-PATLGADGPPPGPPTPPPEDIPAPTEPTPASEAT 786 S T+S+P T + K G N P P +LG+ P + + T P+ S+ T Sbjct: 277 SLSTQSLPVV-TSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPT 335 Query: 787 -------GAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPA--------- 830 + T P S PP+ + E T AA PV K P+ Sbjct: 336 VKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSP 395 Query: 831 AEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 890 + L V T + P S + + AT L A+ G Sbjct: 396 SGSLNVATSFSLSPTTSLILKSSPN------------ATYHYPLVAQMPVSSVGTTPLVV 443 Query: 891 SS-----GAPQDSDSSATC-----SADEVDEAEGGDKNRLL-------SPRPSLLTPTGD 933 ++ AP + ATC S+ + E L+ P + T Sbjct: 444 TNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRI 503 Query: 934 PRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESD 993 P + P P DLK L P Q P + AP PA ++ Sbjct: 504 PVSPPLPD-PEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPL 562 Query: 994 APQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREV 1053 P +SP +S S +P E A A+K G+P LP P + Sbjct: 563 VQAAPKNSPSFQSTSSSPEIPLSPE--------ATLAKKSLGEP------LPIGKPASSM 608 Query: 1054 IKASPHAPDPSAF-----SYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLIS--SAKHP 1106 SP + SA SYA P PL P + P S P ++ +AK Sbjct: 609 --TSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGT 666 Query: 1107 SVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPR 1166 S +G +V L P + K G +T LPL + P + Q +P Sbjct: 667 STYTTTASPFLEG-TVSL-APKNHPVKE--GTLTT-LPLVPTASENCPVAPSPQNTCAPL 721 Query: 1167 GQA--GP--PESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITH 1222 P P+S+ P+ A G+ PG GI T + A + + T Sbjct: 722 ATLVLAPEIPKSVPSPSLPPA--------GTPPGTKKVDGISHTSALAPVASSPKECPTE 773 Query: 1223 --GTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQC 1280 G A KGT+T + DSPS L G+SV+ Sbjct: 774 DSGASATASSKGTLTYLA--DSPSPL---------------------------GVSVSPQ 804 Query: 1281 SKEDG--RSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKE 1338 +K + S+GP +E +S S +G + P HSP Sbjct: 805 TKRPPTKKGSAGPDTPIGNLSSPVSPVEASF-LPENSLSFQG--SKDSPATTHSPTPPSP 861 Query: 1339 QHHIRGS-ITQGIPRSYVEAQEDYLRREAKLLK--REGTPPPPP---PSRDLTEAYKTQA 1392 + S +T P+ ++ L +EG P P P+ +T + +A Sbjct: 862 KGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKA 921 Query: 1393 LGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTPLKYDT 1452 + PA +G+ A+ G TP P P K G T Sbjct: 922 ----RATPAPKGIPASPSPKGAP-----------TPPAATPPSP-KGGPATPSPKWAPTP 965 Query: 1453 GASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLKSRPGTASSSGGS 1512 A+T S K G P P P A S K P T S G Sbjct: 966 PAATPPSPK-------GGPATPSPKGAPTPPAATP---------PSPKGGPATPSPKG-- 1007 Query: 1513 IARGAPVIVPEL--GKPRQSPLTY-----------EDHGAPFAGHLPRGSPVTTREPTPR 1559 A P + P G P +P G+P A LP+G+P T P Sbjct: 1008 -APTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066 Query: 1560 LQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRS-- 1617 + G + S +TP P + P+ P P + +G ++ Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAP 1126 Query: 1618 HIPLAFDP-------TSIPRGIPLDAAAAYYLPR-HLAP-----NPTYPHLYPPYLIRGY 1664 P A P T P+G P AA P+ LA PT P PP G Sbjct: 1127 TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG- 1185 Query: 1665 PDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIID 1724 A + T AT + A +P L P+G Sbjct: 1186 --LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGL-ATPSPKG--- 1239 Query: 1725 LSQVPHLPVLVPPTP-GTPATAMDRLAYLPTAPQPFSSR-------HSS-------SPLS 1769 P P PP+P G PAT + A P A P S + H +P S Sbjct: 1240 ---APTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPS 1296 Query: 1770 PGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSS 1829 P G + P + + K T +P GT ++ Sbjct: 1297 PKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSP---KGTPTLPATT 1353 Query: 1830 GSSGGGGGSSSR------PA---SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITA 1880 SS GG + S PA SH +P SP+ A+ + + + Sbjct: 1354 PSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK 1413 Query: 1881 VEPSTPTVLRSTSTSS--PVRPAATFP------PATHCPLGGTL------DGVYPTLMEP 1926 P+TP +T S + P A P PAT P GG D P + P Sbjct: 1414 KAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPP 1473 Query: 1927 VLLPKEAP---RVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHA 1983 PKE P +VA P+ P + P+S + P P++ A Sbjct: 1474 --SPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTA 1531 Query: 1984 TI--ARTPAKNLAPHHA-------------SPDPPAPPASASDPHREKTQSKPF------ 2022 T+ +TPA LAP A +P P P + + P ++ S P Sbjct: 1532 TLLSKKTPA-TLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTY 1590 Query: 2023 ----SIQELELRSLGYHGS---SYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2075 S +EL + S + +P V P SP P+ KG P S + Sbjct: 1591 KGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDS 1650 Query: 2076 ELRP--------------KQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQ 2121 P + P K G A + P PES P + TAP KG Q Sbjct: 1651 PTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTP-----IITAPTRKGPQ 1705 Query: 2122 RVVTLAQHISEVITQDYTRHHPQQ--LSAPLPAPLYSFPGASCPVL---DLRRPPSDLYL 2176 + A S I D + + + LS PAPL S D P Sbjct: 1706 TKKSSA--TSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLA 1763 Query: 2177 PPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIE-PVSPPEGMTEP 2225 PP + + E K P+P SV + P++P T P Sbjct: 1764 PPESKASTPLTAAAFE--KVLPKPESASVSAAPSPPVSLPLAPSPVPTLP 1811 Score = 54.3 bits (129), Expect = 1e-06 Identities = 133/567 (23%), Positives = 179/567 (31%), Gaps = 120/567 (21%) Query: 1717 AGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSS--PLSPGGPT 1774 + P ++ S +P + + +PAT + PT P P + S+ PLSP G T Sbjct: 825 SSPVSPVEASFLPENSLSFQGSKDSPATT-----HSPTPPSPKGAPTPSAVTPLSPKGVT 879 Query: 1775 HLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGG 1834 K T T S V + P + G + + Sbjct: 880 LPPKETPTPS---------------------------VVNLPFPKEGPATPAPKQAPALS 912 Query: 1835 GGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTST 1894 SS + A + A + P SP + A P KG P+TP+ Sbjct: 913 MTSSSPKKARATPAPKGIPASPSPKGA--PTPPAATPPSPKG-----GPATPS-----PK 960 Query: 1895 SSPVRPAATFP-----PATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHA 1949 +P PAAT P PAT P G P P PK P A P A T A Sbjct: 961 WAPTPPAATPPSPKGGPATPSPKGAPTP---PAATPPS--PKGGP--ATPSPKGAPTPPA 1013 Query: 1950 FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASA 2009 PP+ G A+ KG+ P P S + A TP AP + P+P Sbjct: 1014 --VTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGP 1071 Query: 2010 SDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELD 2069 + P + + +P P SP P+ KG P Sbjct: 1072 ATPSLK---------------------GAPTPPAATPPSPKGGPATPSPKGAPMPPAATP 1110 Query: 2070 KSHLEGELRPKQPG---------PVKLGGEAAHLPHLRP-LPESQPSSSPLLQTAPGVKG 2119 S G P G P GG A P P P + P S P KG Sbjct: 1111 PSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKG 1170 Query: 2120 HQRVVTLAQHISEVITQDYTRHHPQ-QLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPP 2178 T T P+ L+ P P + P A+ P P L P Sbjct: 1171 ------------APTTPAATPPSPKGGLATPSPKGAPTTPAATPP-----SPKGGLATPS 1213 Query: 2179 PDHG--APARGSPHSEGGKRSPE----PNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAV 2232 P PA P +GG +P P + G PP+G P A Sbjct: 1214 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTP----PAA 1269 Query: 2233 YPLLYRDGEQTEPSRMGSKSPGNTSQP 2259 P + G T P + G+ +P + P Sbjct: 1270 TPPSLKGGLATPPHK-GAPNPAVVTPP 1295 Score = 43.5 bits (101), Expect = 0.003 Identities = 129/595 (21%), Positives = 188/595 (31%), Gaps = 98/595 (16%) Query: 1716 AAGPRGIIDLSQVPHLPVLVPPTPGTPATAMD---RLAYLPTAPQPFSSRHSSSPLSPGG 1772 ++GP I+ + P V+ P P P+T + R+ P P P ++ S + Sbjct: 468 SSGPISNIEPTS-PAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKF 526 Query: 1773 PTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSS 1832 PT T +S E + +++ ++L V+ AP P + +S S Sbjct: 527 PTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVL---PLVQAAPKNSPSFQSTSSSPEIP 583 Query: 1833 GGGGGSSSRPASHSHAHQHSPISPRTQD-ALQQRPSVLHNTGMKGIITAVEPSTPTVLRS 1891 + ++ + P S T + SV+ G P + L Sbjct: 584 LSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAG------PDSAGPLLK 637 Query: 1892 TSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFL 1951 +S +P A FP + P G AP A+ T FL Sbjct: 638 SSLITPT--VAAFPLESADPAG------------------VAPTTAKGTSTYTTTASPFL 677 Query: 1952 AKPPARSGLEPASSPSKGS--EPRPLVPPVSGHATIARTPAKNLAP----------HHAS 1999 L P + P K PLVP S + +A +P AP + Sbjct: 678 ---EGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSV 734 Query: 2000 PDPPAPPAS--------------------ASDPHREKTQSKPFSIQELELRSLGYHGSSY 2039 P P PPA AS P T+ S +L Y S Sbjct: 735 PSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSP 794 Query: 2040 SPEGVEPVSPVSS--PSLTHDKGLPKHLEELDK--SHLEGELRPKQPGPVKLGGEAAHLP 2095 SP GV VSP + P+ G + L S +E P+ + ++ Sbjct: 795 SPLGVS-VSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATT 853 Query: 2096 HLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQH---ISEVITQDYTRHHPQQLSAPLPA 2152 H P + + +P T KG VTL V+ + + P AP A Sbjct: 854 HSPTPPSPKGAPTPSAVTPLSPKG----VTLPPKETPTPSVVNLPFPKEGP-ATPAPKQA 908 Query: 2153 PLYSFPGASCPVLDLRRPPSDLYLPPPDHGA---PARGSPHSEGGKRSPEPNKTSVLGGG 2209 P S +S P + P GA PA P +GG +P P Sbjct: 909 PALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT---- 964 Query: 2210 EDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMG---SKSPGNTSQPPA 2261 P SP G P + P T PS G + SP PPA Sbjct: 965 PPAATPPSPKGGPATPSPKGAPTPP------AATPPSPKGGPATPSPKGAPTPPA 1013 Score = 38.1 bits (87), Expect = 0.11 Identities = 57/241 (23%), Positives = 87/241 (36%), Gaps = 40/241 (16%) Query: 684 KKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAK 743 +K P A PP+ D S +G++ + A A + S T K Sbjct: 1701 RKGPQTKKSSATSPPICPDP----SAKNGSKGPLSTVAPAPLLPVQKDSS----KTAKGK 1752 Query: 744 DTGQN--GPKPPATLGADGPPPGPP----TPPPEDIPAPTEPTPASEATGAPTPPPAPPS 797 D + GP P A P P PE P+P AP+P P P Sbjct: 1753 DASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPP 1812 Query: 798 -----PSAP--------PPVVPKEEKE-------EETAAAPPVEEGEEQKP-PAAEELAV 836 PS+P P+ P +E E E + P + P P + + V Sbjct: 1813 KQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPV 1872 Query: 837 DTGKAEEPV----KSECTE-EAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKS 891 T A++PV K TE +++E + ++ ++ +AT + A A E + AK Sbjct: 1873 PTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQ 1932 Query: 892 S 892 S Sbjct: 1933 S 1933 Score = 37.7 bits (86), Expect = 0.14 Identities = 57/215 (26%), Positives = 75/215 (34%), Gaps = 32/215 (14%) Query: 1002 PRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGD---PPCWTSGLPFPVPPREVIKASP 1058 P + P P A+ A P+ A PG PPC S P P +ASP Sbjct: 10 PATEQELPQPQAET-AVLPMSSALSVTAALGQPGPTLPPPC--SPAPQQCPLSAANQASP 66 Query: 1059 HAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQ 1118 P PS + P P P TA P+ P + P LI P+ L A++ Sbjct: 67 F-PSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAAL-----ALAS 120 Query: 1119 GMSVQLHVPYSEHAKAPVGPVTMGLP---LPMDPKKLAPFSGVKQEQLSPRGQAGPPESL 1175 M + P G P P+ LAP S K P PP S+ Sbjct: 121 PM---------------IAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPP-SV 164 Query: 1176 GVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPS 1210 V + L S P ++ K +PS VP+ Sbjct: 165 AVAESGSVITLSAPIAPSEPKTNLNK-VPSEVVPN 198 Score = 37.0 bits (84), Expect = 0.24 Identities = 75/320 (23%), Positives = 112/320 (35%), Gaps = 24/320 (7%) Query: 722 EATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 781 EAT + + +P P E A + A LG GP T PP PAP + P Sbjct: 4 EATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGP-----TLPPPCSPAP-QQCP 57 Query: 782 ASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA 841 S A A +P P+P + ++ P VP + TA P+ E + A Sbjct: 58 LSAANQA-SPFPSPSTIASTPLEVPFPQSSSGTAL--PLGTAPEAPTFLPNLIGPPISPA 114 Query: 842 EEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSS 901 + S +G A A A ++ +K T+ S A +S S Sbjct: 115 ALALASPMIAPTLKGTPSSSAPLALVALAPHSV--QKSSAFPPNLLTSPPSVAVAESGSV 172 Query: 902 ATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQV 961 T SA + N++ PS + P +P+ SP P + + + P+ Sbjct: 173 ITLSAPIAPSEPKTNLNKV----PSEVVP--NPKGTPSP--PCIVSTVPYH--CVTPMAS 222 Query: 962 TKVHEPPREDAAPTKPAPPAPPPPQNLQPES--DAPQQPGS-SPRGKSRSPAPPADKEAE 1018 + PT A P ++ S +PQ PGS S +G PA + Sbjct: 223 IQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQS 282 Query: 1019 KPVFFPAFAAEAQKLPGDPP 1038 PV + P D P Sbjct: 283 LPVVTSSQKTAGPNTPPDFP 302 Score = 35.4 bits (80), Expect = 0.70 Identities = 48/241 (19%), Positives = 81/241 (33%), Gaps = 39/241 (16%) Query: 685 KAPAAASEEAAFPPVVEDEEMEASGVSGNEEEM------VEEAEATVNNSSDTESIPSPH 738 K P + A PV +D A G + +A + ++ + +P P Sbjct: 1727 KGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPE 1786 Query: 739 TEAAKDTGQNGPKPPATLGADGPPPGPPTPPPED---------IPAPTEP-TPASEATGA 788 + + P PP +L P P P PP + + +P++P PA E Sbjct: 1787 SASVSAA----PSPPVSLPL-APSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELL 1841 Query: 789 PTPPPAP--------------PSP---SAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAA 831 P PP P P+P P P ++ + E ++ P Sbjct: 1842 PLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPEL 1901 Query: 832 EELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKE-GGSGRATTAK 890 EE ++ + E EE +K K + + + + K ++ G R T K Sbjct: 1902 EEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRK 1961 Query: 891 S 891 S Sbjct: 1962 S 1962 >gi|210032580 SET domain containing 1B [Homo sapiens] Length = 1923 Score = 92.0 bits (227), Expect = 6e-18 Identities = 139/631 (22%), Positives = 208/631 (32%), Gaps = 107/631 (16%) Query: 483 VRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDK 542 VRR R + ++ +++ ++Q+ + E++E+E++ + + +++ E END Sbjct: 1019 VRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDD 1078 Query: 543 EDLLKEKTDDTSGEDNDEKEAVA---SKGRKTANSQGRRKGRITRSMANEANSEEAITPQ 599 ED + + D+DE+E V+ SK T++S+ S ++E S +P Sbjct: 1079 EDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSES--------SESSEFESSSESSPS 1130 Query: 600 QSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKR 659 S + + E EEE A++ + G Sbjct: 1131 SSEDEEEVVAREEEEEEEEEEMVAEESMASAGPE-------------------------- 1164 Query: 660 QNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEE-EMV 718 E++ APA S + E+ ++E V+ E M+ Sbjct: 1165 ------------DFEQDGEEAALAPGAPAVDS-----LGMEEEVDIETEAVAPEERPSML 1207 Query: 719 EEAEATVNNSSDTESIPSPHTEAAKDTGQN--GPKPPATLGADGPPPGPPTPPPEDIPA- 775 +E V +S P G P+PPA PP P P D+ Sbjct: 1208 DEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVE 1267 Query: 776 PTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELA 835 P P P PPP PP P +PP P+ E + + + P E E PP L Sbjct: 1268 PEPPMMLPLPLQPPLPPPRPPRPPSPP---PEPETTDASHPSVPPEPLAEDHPPHTPGLC 1324 Query: 836 VDTGKAEEPVKSECTEEAE---EGPAKGKDAEAAEATAE----GALKAEKKEGGSGRATT 888 K++ T E G + G + + A GG R Sbjct: 1325 GSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPG 1384 Query: 889 AKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQ 948 S P S+ S G R +L TG P P PL L Sbjct: 1385 RDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLP-LPLPL-- 1441 Query: 949 LKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRS 1008 A+P + + P P PAP A PP P P +P SP Sbjct: 1442 ------ALPAVLRAQARAP--TPLPPLLPAPLASCPP----PMKRKPGRPRRSPPSMLSL 1489 Query: 1009 PAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSY 1068 P +P A E LPG P PV P S H P + Sbjct: 1490 DGP-----LVRPPAGAALGRELLLLPGQPQT-------PVFP------STHDPRTVTLDF 1531 Query: 1069 APPGHPLPLGLHDTARPVLPRPPTISNPPPL 1099 G P P P+ P+PP PPP+ Sbjct: 1532 RNAGIPAP------PPPLPPQPPPPPPPPPV 1556 Score = 59.7 bits (143), Expect = 3e-08 Identities = 89/406 (21%), Positives = 153/406 (37%), Gaps = 73/406 (17%) Query: 780 TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839 TP A P P+ P + E++E+ + + E EE++ EE Sbjct: 1005 TPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEE------ 1058 Query: 840 KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 899 EE + +++ +E +D +EA+ + ++++E S + A+++ + + S+ Sbjct: 1059 -EEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSE 1117 Query: 900 SSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQK--PLDLKQLKQRAAAIP 957 SS S+ E + D+ +++ + A S P D +Q + AA P Sbjct: 1118 SSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAP 1177 Query: 958 PIQVTKVHEPPREDAAPTKPAPPA--------PPPPQNLQPESDA---PQQPGSSPRGKS 1006 E T+ P PP P ++ +D+ P++PG S G Sbjct: 1178 GAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAM 1237 Query: 1007 R-SPAPPADKEAEKPVFFPAFAAEAQ-KLPGDPPCWTSGLPFPVPPREVIKASPHAPDPS 1064 SP PPA + +P P A E ++ +PP LP P+ P Sbjct: 1238 LLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMM---LPLPLQP-------------- 1280 Query: 1065 AFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPL--ISSAKHPSVLERQI--------- 1113 PLP PRPP +PPP + A HPSV + Sbjct: 1281 ---------PLPP----------PRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTP 1321 Query: 1114 ---GAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFS 1156 G++++ S + VP + + P+ + GL L +PFS Sbjct: 1322 GLCGSLAKSQSTET-VPATPGGEPPLSGGSSGLSLSSPQVPGSPFS 1366 Score = 55.8 bits (133), Expect = 5e-07 Identities = 115/499 (23%), Positives = 156/499 (31%), Gaps = 110/499 (22%) Query: 750 PKPPATLGADGPPPGPPTPPP-------------EDIPAPTEPTPASEATGA-------- 788 P+ AT A PPP TP P P P E A+ A GA Sbjct: 372 PQDSATF-AHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRR 430 Query: 789 -PTPPPAPPS-------PSAPPPVVPKEEKEEETAAAPPVEEGEE----------QKPPA 830 P PPP PP+ P PP P + E P E + PA Sbjct: 431 APAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPA 490 Query: 831 AEELAVDT--GKAEEPVKSECTE-------------EAEEGPAKGKDAEAAEATAEGALK 875 E D+ + E +K + T+ + E P ++ + G Sbjct: 491 GPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNS 550 Query: 876 AEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPR 935 G + ++ S+G +D + +DE +E + G L PRP DP Sbjct: 551 QPGFRGPTPPSSRPSSTGL-EDISPTPLPDSDEDEELDLG-----LGPRPPPEPGPPDPA 604 Query: 936 ANASPQKPLDLKQLKQRAAAIPPI----QVTKVHEPPREDAAPTKPAPPAP-PPPQNLQP 990 S + L + R + Q + +D P+ P A P P + P Sbjct: 605 GLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTP 664 Query: 991 ESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPP 1050 + A P P PP P FP LP PP FP+PP Sbjct: 665 GAAAVAAPSVL---APTLPLPP-------PPGFP-------PLPPPPPPPPPQPGFPMPP 707 Query: 1051 REVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPL------ISSAK 1104 + P P P+ + P PLP A P +P PP + PP + Sbjct: 708 --PLPPPPPPPPPAHPAVTVPPPPLP------APPGVPPPPILPPLPPFPPGLFPVMQVD 759 Query: 1105 HPSVLERQIGAISQGMSVQLHV-----------PYSEHAKAPVGPVTMGLPLPMDPKKLA 1153 VL Q G + +Q V PY A + GL P Sbjct: 760 MSHVLGGQWGGMPMSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRG 819 Query: 1154 PFSGVKQEQLSPRGQAGPP 1172 PFS RGQ PP Sbjct: 820 PFS--LSNSGPGRGQHWPP 836 Score = 53.5 bits (127), Expect = 2e-06 Identities = 35/116 (30%), Positives = 42/116 (36%), Gaps = 8/116 (6%) Query: 712 GNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKP----PATLGADGP----PP 763 G+ E+ + +S + I +A T + PKP P P P Sbjct: 619 GDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPT 678 Query: 764 GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819 P PPP P P P P G P PPP PP P PPP P APP Sbjct: 679 LPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPP 734 Score = 52.8 bits (125), Expect = 4e-06 Identities = 119/527 (22%), Positives = 162/527 (30%), Gaps = 103/527 (19%) Query: 1740 GTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTK--PTTTSSSERERDRDRERDR 1797 GTP T P PFS S S P P++L P T + R + + Sbjct: 272 GTPLT--------PRLGTPFSQDSSYSSRQPT-PSYLFSQDPAVTFKARRHESKFTDAYN 322 Query: 1798 DREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPR 1857 R + S A S G+ GG GGSS P P+ Sbjct: 323 RRHEHHYVHNSPAVTAVAGATAAFRGSSDLPFGAVGGTGGSSGPPFK---------AQPQ 373 Query: 1858 TQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCP-----L 1912 P T G +A P P A FPP P Sbjct: 374 DSATFAHTPPPAQATPAPGFKSAFSPYQT-------------PVAHFPPPPEEPTATAAF 420 Query: 1913 GGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEP 1972 G G + P LP P E+P G PP + +E P+ G P Sbjct: 421 GARDSGEFRRAPAPPPLPPAEPLAK--EKPGTPPG----PPPPDTNSMELGGRPTFGWSP 474 Query: 1973 RPLVPPVSGHATIARTPAKNLAPHHASP--------DPPAPPASASDPHRE---KTQSKP 2021 P P G T+ +PA PH + + +P + + + P Sbjct: 475 EPCDSP--GTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSP 532 Query: 2022 FSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGL-PKHLEELDKSH-LE---GE 2076 S +L L G++ P P P S PS T + + P L + D+ L+ G Sbjct: 533 ISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGP 592 Query: 2077 LRPKQPGPVKLGGEAAHLPHLR-PLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVIT 2135 P +PGP G + + L + +S + G ++ + S IT Sbjct: 593 RPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPIT 652 Query: 2136 QDYTRHHPQQLSAPLPAPLYSFPGASC--------PVLDLRRPPSDLYLPPPDHGAPARG 2187 SA P P+ PGA+ P L L PP LPPP P Sbjct: 653 -----------SADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPP--- 698 Query: 2188 SPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYP 2234 P+P G P+ PP P H V P Sbjct: 699 ----------PQP--------GFPMPPPLPPPPPPPPPAHPAVTVPP 727 Score = 49.3 bits (116), Expect = 5e-05 Identities = 35/110 (31%), Positives = 46/110 (41%), Gaps = 13/110 (11%) Query: 700 VEDEEMEASGVSGNE--EEMVEE--AEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPAT 755 + D+EM ++ ++ + + MV A A S ++P P P PP Sbjct: 641 ISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQ 700 Query: 756 LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVV 805 G PPP PP PPP P PA A P PPP P P PPP + Sbjct: 701 PGFPMPPPLPPPPPP--------PPPAHPAVTVP-PPPLPAPPGVPPPPI 741 Score = 40.4 bits (93), Expect = 0.022 Identities = 26/75 (34%), Positives = 29/75 (38%), Gaps = 5/75 (6%) Query: 761 PPPGPPTPPPEDIPAPTEPT--PASEATGAPTPPPAPPSPSAPPPVVPKE---EKEEETA 815 PPP PP PPP P P EPT P E PP P V + K Sbjct: 1540 PPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPW 1599 Query: 816 AAPPVEEGEEQKPPA 830 PP + E+ PPA Sbjct: 1600 RRPPKKRHEDLVPPA 1614 Score = 37.4 bits (85), Expect = 0.18 Identities = 38/121 (31%), Positives = 47/121 (38%), Gaps = 28/121 (23%) Query: 748 NGP--KPPA--TLGAD-----GPPPGPPTPPPED------------IPAPTEPTPASEAT 786 +GP +PPA LG + G P P P D IPAP P P Sbjct: 1490 DGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQ--- 1546 Query: 787 GAPTPPPAPPSPSAPPPVVPKE-EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPV 845 P PPP PP P P + KE + + + A PP G ++ ELA G P Sbjct: 1547 --PPPPPPPP-PVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPP 1603 Query: 846 K 846 K Sbjct: 1604 K 1604 Score = 37.0 bits (84), Expect = 0.24 Identities = 105/444 (23%), Positives = 143/444 (32%), Gaps = 86/444 (19%) Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSS 1840 T S E+D E D D E SI+TS +++ SS SS SS Sbjct: 1081 TALSEASEKD---EGDSDEEETVSIVTSKA-------------EATSSSESSESSEFESS 1124 Query: 1841 RPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMK----------GIITAVEPSTPTV-- 1888 +S S + + R ++ ++ ++ M G A+ P P V Sbjct: 1125 SESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDS 1184 Query: 1889 --------LRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPE 1940 + + + + RP+ P + D P E L +E + PE Sbjct: 1185 LGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPP--EEPGLSQEGAMLLSPE 1242 Query: 1941 RPRADTGHAFLAKPPARSGLEPASSPSKGSE----------------------PRPLVPP 1978 P + A+PP L P +P E PRP PP Sbjct: 1243 PPAKEVE----ARPP----LSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPP 1294 Query: 1979 VSGHATIA---RTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYH 2035 T A P + LA H P + A E + P L S G Sbjct: 1295 PEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLS 1354 Query: 2036 GSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLP 2095 SS G P SPSL+ GLP+ D S P GP+ L LP Sbjct: 1355 LSSPQVPGSPFSYPAPSPSLS-SGGLPR-TPGRDFSFTPTFSEPS--GPLLL--PVCPLP 1408 Query: 2096 HLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLP-APL 2154 R S P +SP+L + L + V+ Q AP P PL Sbjct: 1409 TGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLR--------AQARAPTPLPPL 1460 Query: 2155 YSFPGASCPVLDLRRPPSDLYLPP 2178 P ASCP R+P PP Sbjct: 1461 LPAPLASCPPPMKRKPGRPRRSPP 1484 Score = 33.5 bits (75), Expect = 2.7 Identities = 66/312 (21%), Positives = 98/312 (31%), Gaps = 33/312 (10%) Query: 1719 PRGIIDLSQVPHLPVLVPPTPGTPATAMDRL--AYLPTAPQPFSSRHSSSPLSPGGPTHL 1776 P ++ L P LP PP P +P + ++ P+P + H P +PG L Sbjct: 1270 PPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHP--PHTPGLCGSL 1327 Query: 1777 TKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSG--SSGG 1834 K +T + + + S+ V +P P S S G + G Sbjct: 1328 AKSQSTETVPATPGGEPPLSGG---SSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPG 1384 Query: 1835 GGGSSSRPASHSHAHQHSPISPRTQDALQQRPS-----VLHNTGMKGIITAVEP---STP 1886 S + S P+ P +R VL TG+ + P + P Sbjct: 1385 RDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALP 1444 Query: 1887 TVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADT 1946 VLR+ + + P P CP P P +L + P Sbjct: 1445 AVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGP------------ 1492 Query: 1947 GHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPP 2006 L +PPA + L G P+ P T+ P P PP PP Sbjct: 1493 ----LVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPP 1548 Query: 2007 ASASDPHREKTQ 2018 P E T+ Sbjct: 1549 PPPPPPPVEPTK 1560 Score = 32.7 bits (73), Expect = 4.5 Identities = 36/124 (29%), Positives = 52/124 (41%), Gaps = 13/124 (10%) Query: 95 LGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPP 154 LG E IE++ E P L P + +PA S + ++ L+ + + P PP Sbjct: 1185 LGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPP 1244 Query: 155 HTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPV 214 E+E PP LS E ++ V+ E M+ L Q PP P +P Sbjct: 1245 AK--EVEARPP-LSPERAPEHDLEVEPEPPMM------LPLPLQP----PLPPPRPPRPP 1291 Query: 215 SPPP 218 SPPP Sbjct: 1292 SPPP 1295 >gi|112382226 atrophin-1 like protein isoform b [Homo sapiens] Length = 1012 Score = 89.0 bits (219), Expect = 5e-17 Identities = 163/657 (24%), Positives = 225/657 (34%), Gaps = 105/657 (15%) Query: 546 LKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAEL 604 +KE+ D SG+ + S+G + GR+K + + N + + + S Sbjct: 5 VKEEDDGLSGKHSMRTRR--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSA 62 Query: 605 ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664 AS N+S + ET KK A+ V + S K+ KRQ Sbjct: 63 ASTSSNDS------KAETVKKS-----------AKKVKEEASSPLKS-----NKRQ---- 96 Query: 665 ILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEAT 724 + K+ + E R KK P E E ++ V N+E + + Sbjct: 97 ---REKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSV--NDEGSSDPKDID 151 Query: 725 VNNSSDTESIPSPH-TEAAKDTGQNGP----KPPATLGADGPPPGPPTPPPEDIPAPTE- 778 +N S + SIPSP E+ D+ +PPA G P P + PP PT Sbjct: 152 QDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG 211 Query: 779 PTPASEAT---GAPTPPPAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQKPPAAEE 833 PTP++ A G+PT AP P AP VP ++ A P P P Sbjct: 212 PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPP 271 Query: 834 LAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSG 893 L TG A +P + P G+ + G L + G Sbjct: 272 LQPLTGSAGQP----SAPSHAQPPLHGQGPPGPHSLQAGPL--------------LQHPG 313 Query: 894 APQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRA 953 PQ S +A G P SL P A S Q P R Sbjct: 314 PPQPFGLPPQASQ---GQAPLGTSPAAAYPHTSLQLPASQ-SALQSQQPP--------RE 361 Query: 954 AAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPA 1013 +PP + H P PT P P P P + P P G SP + + PP Sbjct: 362 QPLPPAPLAMPHIKP----PPTTPIPQLPAPQAHKHP----PHLSGPSPFSMNANLPPP- 412 Query: 1014 DKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREV--IKASPHAPDPSAFSYAPP 1071 A KP+ + P P P P + + S + P P P Sbjct: 413 --PALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPP------PA 464 Query: 1072 GHPLPLGLHDTA-RPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSE 1130 HP P GLH A +P + P + PP I+ PS G G S Q P Sbjct: 465 SHP-PTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAG---PGTSAQ---PPCS 517 Query: 1131 HAKAPVGPVTMG--LPLP-MDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184 A A G + G PLP + K+ A + E P ++ PE V T AS Sbjct: 518 GAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHAS 574 Score = 47.8 bits (112), Expect = 1e-04 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%) Query: 1786 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1845 ERER++++E++R+RERE+ E + SS G S P Sbjct: 627 EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 669 Query: 1846 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1904 H P P + +T + T E + P V+ T+ + P P Sbjct: 670 GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 727 Query: 1905 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1961 P A H P L V PT+ E L +E R R R F KPP L Sbjct: 728 DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 784 Query: 1962 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2018 PA++P + +PP +G PH AS P P Q Sbjct: 785 PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 831 Query: 2019 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2078 +P L + H + +P++ + ++T P H + SH+ L Sbjct: 832 LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 883 Query: 2079 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2136 Q P+ G P + PL ++ P L P G L Q H E++ Sbjct: 884 LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 938 Query: 2137 D-YTRHHPQQLSAPLPAPL 2154 + +P+ L +P P+ Sbjct: 939 PVFGTPYPRDLPGAIPPPM 957 Score = 43.5 bits (101), Expect = 0.003 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%) Query: 1389 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1447 K +A PLK K E + + +EA R+ + + + P P EG + Sbjct: 83 KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 138 Query: 1448 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1506 + D G+S D RS T P + P D +D+ + + ++ L+++P Sbjct: 139 VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 187 Query: 1507 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1560 + G AP P+L P +P G+P A P P P P Sbjct: 188 QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 246 Query: 1561 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1594 Q +L + + LT + + + H+ P H Sbjct: 247 QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 306 Query: 1595 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1644 HP P P+ + G + A+ TS+ A + PR Sbjct: 307 PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 366 Query: 1645 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1689 H+ P PT P H +PP+L P + ++S HH Sbjct: 367 APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 425 Query: 1690 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1749 +A ++ P SS A P G L+Q +LP PP P T + ++ Sbjct: 426 PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 474 Query: 1750 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1809 A PQP ++H P PGGP +T PT S+S Sbjct: 475 A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 502 Query: 1810 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1853 P PGT SG++ GG G SS P A + P Sbjct: 503 -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 557 Query: 1854 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1913 SP + + PS H + ++ + R+ P+ G Sbjct: 558 RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 602 Query: 1914 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1958 L +E +EA + AR ER R + A A A Sbjct: 603 SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 660 Query: 1959 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2003 G L EP P VPP G T A RT ++ PH SP P Sbjct: 661 GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 720 Query: 2004 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2044 P + +DP RE + + + I+E ELR G P + Sbjct: 721 YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 780 Query: 2045 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2085 +P+ P ++P +LT H L L++ L +LRP+ P Sbjct: 781 DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 840 Query: 2086 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2143 +L E H + L + + P H + + L H + + Q HP Sbjct: 841 RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 900 Query: 2144 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2173 L+A + +P + P L +PP + Sbjct: 901 LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 932 Score = 39.7 bits (91), Expect = 0.037 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%) Query: 1953 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2012 K A+ E ASSP K S R S RT +K S P S S+ Sbjct: 76 KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 129 Query: 2013 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2072 E + S RS+ GSS P+ ++ + +SPS+ P+ E S Sbjct: 130 EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 174 Query: 2073 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2132 + ++ QP ++ + P P S P +P L T V Sbjct: 175 AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 225 Query: 2133 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2192 T + PQ +AP+P P L +RPPS P P P + S Sbjct: 226 --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 279 Query: 2193 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2252 G +P + + G G G + + PG + P G+ + + Sbjct: 280 GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 339 Query: 2253 PGNTSQPPAFFSKL 2266 P + Q PA S L Sbjct: 340 PHTSLQLPASQSAL 353 Score = 36.2 bits (82), Expect = 0.41 Identities = 42/185 (22%), Positives = 61/185 (32%), Gaps = 25/185 (13%) Query: 670 KLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSS 729 KL ++E + K++A A EE ++E E E E E A ++S+ Sbjct: 604 KLAKKREEAIEKAKREAEQKAREERE-----REKEKEKEREREREREREAERAAKASSSA 658 Query: 730 DTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI-----PAPTEPTPASE 784 + P + PP T+ A P GP TP + P PT + Sbjct: 659 HEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNH 718 Query: 785 ATGAPTPPPAP------PSPSAPPPVVPKEEKEEETAAAPPVEE---------GEEQKPP 829 P P P P P + + E E + E G E KPP Sbjct: 719 PFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPP 778 Query: 830 AAEEL 834 + L Sbjct: 779 ELDPL 783 Score = 32.0 bits (71), Expect = 7.7 Identities = 12/45 (26%), Positives = 28/45 (62%) Query: 491 GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535 G +++++ ++ +++ + R +E + EKEKE+E E+E E+ Sbjct: 602 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 646 >gi|150170670 piccolo isoform 2 [Homo sapiens] Length = 4935 Score = 88.6 bits (218), Expect = 7e-17 Identities = 140/668 (20%), Positives = 222/668 (33%), Gaps = 106/668 (15%) Query: 556 EDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRW 615 ++ D GR + + G + SE+ + + + ++ E + Sbjct: 85 QELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDL 144 Query: 616 TEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEK 675 EE + G L SA+ S V++ F + +E ++ K+ ++K Sbjct: 145 KEEHKSSMMPGFLSEVNALSAV-----SSVVNKFNPFDLISDSEASQEETTKKQKV-VQK 198 Query: 676 ERNARRKKKKAPAAASEEAAFP--------PVVEDEEMEASGVSGNEEEMVEEAEATVNN 727 E+ K P P P+ +D ++ +S + E ++ Sbjct: 199 EQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKS--ISSQQPEKIKSQPPGTGK 256 Query: 728 SSDTESIPSPHTEAAKDTGQNGPKPPATLGAD-----GPPPGPPTPPPEDIPAPTEPTPA 782 + +P T+ AK Q P T AD P P+P I PT P Sbjct: 257 PIQGPT-QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315 Query: 783 SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842 ++ G P P P A P + K ++ PPV+ KPPA + Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---------QPL 366 Query: 843 EPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSA 902 P K + E P+ + A A G K ++ G + T + G P+ Sbjct: 367 GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPT-QQVGTPKPLAQQP 425 Query: 903 TCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVT 962 + +A G K + P P + P A P K +Q PP Q+ Sbjct: 426 GLQSPA--KAPGPTKTPVQQPGPGKI-----PAQQAGPGKT----SAQQTGPTKPPSQLP 474 Query: 963 KVHEPPREDAAPTKPAPPAP--------------PPPQNLQPESDAPQQPGSS------- 1001 +PP + P KP P P PPPQ P +PQQPGS+ Sbjct: 475 GPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQP 534 Query: 1002 ----PRGKSRSPAPPADKEAEKPVFF---------PAFAAEAQKLPGDPPCWTSGLPFPV 1048 P + SPA P+ +++ KPV P + A++ P + GLP + Sbjct: 535 GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP------SQGLPKTI 588 Query: 1049 PPR-EVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1107 P + H P+ + F+ L NP P ++ K Sbjct: 589 CPLCNTTELLLHVPEKANFNTCTECQTTVCSLCG------------FNPNPHLTEVKEWL 636 Query: 1108 VLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRG 1167 L Q+ G VP S K PVT S + +Q SP+ Sbjct: 637 CLNCQMKRALGGDLAP--VPSSPQPKLKTAPVT--------TTSAVSKSSPQPQQTSPKK 686 Query: 1168 QAGPPESL 1175 A P + L Sbjct: 687 DAAPKQDL 694 Score = 58.2 bits (139), Expect = 1e-07 Identities = 94/438 (21%), Positives = 151/438 (34%), Gaps = 49/438 (11%) Query: 735 PSPHTEAAKDTGQNGPKPPATLGAD-GPPPGPPTPPPEDIPAPT-----EPTPASEATGA 788 P+PH K+ + LG D P P P P + P T + +P + T + Sbjct: 625 PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQT-S 683 Query: 789 PTPPPAP-------PSPSAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839 P AP P P PPP+V P A P E KP +E +V + Sbjct: 684 PKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743 Query: 840 KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 899 + + PV + ++ + ++ AT + + + K + + TT P +D Sbjct: 744 QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-----PLKTD 798 Query: 900 SSATCSADEVDEAEGGDKNRLLSPRP---SLLTPTGDPRANASPQKPLDLKQLKQRAAAI 956 S+ + + + PRP S + P + + QK +D Q K+ Sbjct: 799 SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE---- 854 Query: 957 PPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKE 1016 P TK+ P+ DA P P PP P+ ++ Q P+ +SR + Sbjct: 855 PKKAQTKMS--PKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912 Query: 1017 AEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS---PHAPDPSAFSYAPPGH 1073 + P + P P +G F +AS A P S + PG Sbjct: 913 TDAP----------KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGA 962 Query: 1074 PLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAK 1133 P+ P +PPT PP A + ++ + + P +E A Sbjct: 963 PM------KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016 Query: 1134 APVGPVTMGLPLPMDPKK 1151 T P P+ K Sbjct: 1017 TVKRTETEKKPPPIKDSK 1034 Score = 54.7 bits (130), Expect = 1e-06 Identities = 114/547 (20%), Positives = 177/547 (32%), Gaps = 75/547 (13%) Query: 1725 LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTH--LTKPTTT 1782 +S+ LP P + +M R L ++ P + S P PG P L+K TT Sbjct: 60 MSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPP---KQSGRPPDPGRPAQPGLSKSRTT 116 Query: 1783 SSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPG--TEQSSGSSGSSGGGGGSSS 1840 + E+ ++S + EH PG +E ++ S+ SS + Sbjct: 117 DTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPF 176 Query: 1841 RPASHSHAHQHSPISPRT-------------QDALQQRPS--VLHNTG-------MKGII 1878 S S A Q + + LQQ+P + G G Sbjct: 177 DLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTP 236 Query: 1879 TAVEPSTPTVLRST--STSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV 1936 ++ P ++S T P++ P H L D P + ++ E+ + Sbjct: 237 KSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP 296 Query: 1937 ARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPH 1996 + P + KPPA+ +P S+ +P P +A+ P P Sbjct: 297 SLPSPSKPPIQQPTPGKPPAQ---QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPV 353 Query: 1997 H--ASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPS 2054 + PPA P + P ++T S+ S ++ ++L +P P P Sbjct: 354 QPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP-GPAKPP- 411 Query: 2055 LTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTA 2114 T G PK L + +P P K G P P+ + P P Q Sbjct: 412 -TQQVGTPKPLAQ----------QPGLQSPAKAPG-----PTKTPVQQPGPGKIPAQQAG 455 Query: 2115 PGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDL---RRPP 2171 PG Q Q P QL P P PG + P +PP Sbjct: 456 PGKTSAQ--------------QTGPTKPPSQLPGPAKPPPQQ-PGPAKPPPQQPGSAKPP 500 Query: 2172 SDL---YLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHS 2228 S PPP PA+ SP G + P S + + T+P Sbjct: 501 SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560 Query: 2229 RSAVYPL 2235 + PL Sbjct: 561 TGSGKPL 567 Score = 49.3 bits (116), Expect = 5e-05 Identities = 95/391 (24%), Positives = 139/391 (35%), Gaps = 80/391 (20%) Query: 840 KAEEPVKSECTEE---AEEGPAKGKDAEAAEATAEGALKA--EKKEGGSGRATTAKSSGA 894 K E PV + + +E+ P K E L+A +KKE + R ++ S Sbjct: 2280 KPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETV 2339 Query: 895 PQDSDSS--ATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 952 SS A +++ +P+ P+G P ++ P KP + Sbjct: 2340 FDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSL 2399 Query: 953 AAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR-----GKSR 1007 + P PP P PP PPPP P P P +SP+ K Sbjct: 2400 DISAQP--------PP--------PPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKL 2443 Query: 1008 SPAPPADKEAEKPVFFPAFAAE------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAP 1061 + A P P+F E + LP C T+ P PVPP+ Sbjct: 2444 TVASPV--TTATPLFDAVTTLETTAVLRSNGLPVTRICTTA--PPPVPPK---------- 2489 Query: 1062 DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP--PPLISSAKHPSVLERQIGAISQG 1119 PS+ +P GL T RP +PP P P L ++ + P+ + + +S Sbjct: 2490 -PSS---------IPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLT 2539 Query: 1120 MSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPR-----GQAGPPES 1174 S+ L++ S K LP P P L+P S + S P Sbjct: 2540 SSMTLNLVTSADYK---------LPSPTSP--LSPHSNKSSPRFSKSLTETYVVITLPSE 2588 Query: 1175 LGVPTAQEASVLRGTALGSVPGGSITKGIPS 1205 G PT AS A+ S P GS +K + S Sbjct: 2589 PGTPTDSSAS----QAITSWPLGSPSKDLVS 2615 Score = 46.2 bits (108), Expect = 4e-04 Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 21/66 (31%) Query: 756 LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE---EKEE 812 + A PPP PP PPP P PPP PP P PPP PK K++ Sbjct: 2401 ISAQPPPPPPPPPPP------------------PPPPPPPPPPPLPPPTSPKPTILPKKK 2442 Query: 813 ETAAAP 818 T A+P Sbjct: 2443 LTVASP 2448 Score = 45.8 bits (107), Expect = 5e-04 Identities = 85/467 (18%), Positives = 182/467 (38%), Gaps = 64/467 (13%) Query: 183 ITMVEQQISKLKKKQQQLEEEAAKPPE--PEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240 ++++E Q S L ++ E+ +P E PE+P +S +L I +E K+++ Sbjct: 1417 LSILEAQASTLADEKS---EKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473 Query: 241 AHRILEGLGPQVELP----------LYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHA 290 + Q ++P + + R+ +++++ + + KRR Sbjct: 1474 ERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSV 1533 Query: 291 RKQWEQKFCQRYDQLMEAWEKKVER--IENNPRRRAKESKVREYYEKQFPEIRKQRELQE 348 ++ Q Q E + + IE + A S+ E+ Q EI E Q+ Sbjct: 1534 GSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQK 1593 Query: 349 RMQSR-------------VGQRGSGLSMSAAR------SEHEVSEIIDGLSEQENLEKQM 389 + +++ + + + A R + E + L +E ++ Sbjct: 1594 KEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES 1653 Query: 390 RQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHP- 448 +L V +R K I +N +AD ++ +++ ++E E E P Sbjct: 1654 EELVVTG----GGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPE 1709 Query: 449 -KNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQ 507 ++ G +S L + ++ +E+ S K + +QQ++ + + Sbjct: 1710 DRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHK-----KGESKQQRKARHRPHG 1764 Query: 508 QQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASK 567 P S EE++ +E+E+ +++E++ E+E + ++ + S +D DE A Sbjct: 1765 PLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQ----RKSSSKKSKKDKDELRA---- 1816 Query: 568 GRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASM-ELNESS 613 RR+ R +N + E+A ++ + A M EL+ SS Sbjct: 1817 --------QRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSS 1855 Score = 45.1 bits (105), Expect = 9e-04 Identities = 69/321 (21%), Positives = 105/321 (32%), Gaps = 72/321 (22%) Query: 708 SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAK-DTGQNGPKPPATLGADGPPPGPP 766 SG + +E+ + + + S + P P ++ D P PP PPP PP Sbjct: 2363 SGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPP--PPPPPPPPP 2420 Query: 767 TPPPEDIPAPTEPTP----------ASEATGA---------------------------- 788 PPP +P PT P P AS T A Sbjct: 2421 PPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICT 2480 Query: 789 PTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEE----P 844 PPP PP PS+ P + + E + PP+ P +L T K + P Sbjct: 2481 TAPPPVPPKPSSIPSGLVFTHRPE--PSKPPI-----APKPVIPQLPTTTQKPTDIHPKP 2533 Query: 845 VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRA--------TTAKSSGAPQ 896 T D + T+ + + K ++ T G P Sbjct: 2534 TGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPT 2593 Query: 897 DSDSSATCSADEVDEAEGGDKNRLLSPRP--SLLTPTGDPRANASPQKPLDLKQLKQRAA 954 DS +S ++ + G L+S P S++ P + + P+ +Q + Sbjct: 2594 DSSASQAITSWPL----GSPSKDLVSVEPVFSVVPPV------TAVEIPISSEQTFYISG 2643 Query: 955 AIPPIQVTKVHEPPREDAAPT 975 A+ T V P AAPT Sbjct: 2644 ALQTFSATPVTAPSSFQAAPT 2664 Score = 43.9 bits (102), Expect = 0.002 Identities = 51/241 (21%), Positives = 92/241 (38%), Gaps = 29/241 (12%) Query: 792 PPAPPSPSAPPPVVPKEEKEEETAAAPP---VEEGEEQKPPAAEELAVDTGK---AEEPV 845 PPAP P A P VP E ++TA P V++ E++ AE++ ++ K + E + Sbjct: 1126 PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKI 1185 Query: 846 KSECTEEAEEGPAKGKDAEAAEATAEGALKAEKK--------EGGSGRATTAKSSGAPQD 897 T + ++ +K + +A+ + L EKK + + P+D Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPED 1245 Query: 898 SDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIP 957 +E K+ LL + + + R +P+ + KQ + + +P Sbjct: 1246 KKLLPEAKTSAPEE----QKHDLLKSQVQIAEEKLEGR--VAPKTVQEGKQPQTKMEGLP 1299 Query: 958 PIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPRGKSRSPAP 1011 + P+ED TK P PP +P+ P ++ S S+ P Sbjct: 1300 SGTPQSL---PKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKS 1356 Query: 1012 P 1012 P Sbjct: 1357 P 1357 Score = 42.7 bits (99), Expect = 0.004 Identities = 93/443 (20%), Positives = 149/443 (33%), Gaps = 71/443 (16%) Query: 770 PEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPP 829 PE + A + G+P+ P A + +EE+ + A + + P Sbjct: 13 PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72 Query: 830 AAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE---AAEATAEGALKAEKKEGGSGRA 886 A + + +E S +++ P G+ A+ + T + +K G S Sbjct: 73 PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132 Query: 887 TTAKSSGAPQDSDSSATCS-----ADEVD--EAEGGDKNRLLSPRPSLLTPTGDPRANAS 939 + K S + D S EV+ A N+ +P + Sbjct: 133 ISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNK-FNPFDLISDSEASQEETTK 191 Query: 940 PQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQP- 998 QK + +Q K PP+Q +PP+ P + P P Q+ P+S + QQP Sbjct: 192 KQKVVQKEQGKPEGIIKPPLQ----QQPPK--PIPKQQGPGRDPLQQDGTPKSISSQQPE 245 Query: 999 ---------GSSPRGKSRSPAP-----PADKEAEKPVFFPAFAAEAQKL------PGDPP 1038 G +G +++P P ++A +P A + + P PP Sbjct: 246 KIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP 305 Query: 1039 CWTSGLPFP-VPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH-DTARPVLPRPPTISNP 1096 P P PP + P P+ P G PL T +P + P T P Sbjct: 306 IQQ---PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPP 362 Query: 1097 PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFS 1156 + AK P+ +Q G+ P SE PK LA Sbjct: 363 AQPLGPAKPPA---QQTGS---------EKPSSEQP---------------GPKALAQPP 395 Query: 1157 GVKQEQLSPRGQAGPP-ESLGVP 1178 GV + G A PP + +G P Sbjct: 396 GVGKTPAQQPGPAKPPTQQVGTP 418 Score = 42.7 bits (99), Expect = 0.004 Identities = 70/346 (20%), Positives = 112/346 (32%), Gaps = 57/346 (16%) Query: 734 IPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPP 793 + P + P +L PP P P +D + P PT Sbjct: 707 VKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDL 766 Query: 794 APPSPSAPPPVVP--KEEKEEETAAAPPVE----EGEEQKPPAAEELAVDTGKAEEPVKS 847 S + P +P K + + E PP++ + + PP E+++ KA S Sbjct: 767 VSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPAS 826 Query: 848 ECTEEAEEGP---AKG--------KDAEAAEATAEGALKAEKKEGGSGRAT--------- 887 + + GP +KG K E +A + + K + K G T Sbjct: 827 DSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAG 886 Query: 888 ----TAKSSGAPQDSD---------------SSATCSADEVDEAEGGDKNRLLSPRPSLL 928 T + S PQ+ S T + V G + S +L+ Sbjct: 887 QTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI 946 Query: 929 TPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNL 988 + G P ++ +KQ A P Q PP+ T APPAP + Sbjct: 947 STAGQPGPHSQSGPGAPMKQ------APAPSQPPTSQGPPKS----TGQAPPAPAKSIPV 996 Query: 989 QPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVF--FPAFAAEAQK 1032 + E+ AP P+ + + E + P + AE QK Sbjct: 997 KKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQK 1042 Score = 40.4 bits (93), Expect = 0.022 Identities = 78/369 (21%), Positives = 132/369 (35%), Gaps = 56/369 (15%) Query: 509 QQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKED---LLKEKTDDTSGEDNDEKEAVA 565 +QP P + K KE E++K V +DK ++K TD S K + Sbjct: 721 KQP-PEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIP 779 Query: 566 SKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKK 625 S ++ +EE TP + S + ++S T E++ Sbjct: 780 SS-------------------KVQSQAEEKTTPPLKTD--SAKPSQSFPPTGEKVSPFDS 818 Query: 626 GLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKK 685 + + S I G + S+ + +K++ ++ + KM + +A+ K Sbjct: 819 KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEP----KKAQTKMSPKPDAKPMPKG 874 Query: 686 APA------AASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDT-------- 731 +P A + P + ++ S N + + ++ +T Sbjct: 875 SPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGF 934 Query: 732 -ESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPT 790 SI S + GQ GP + GA P+ PP P ++TG Sbjct: 935 GASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPP-------KSTGQAP 987 Query: 791 PPPAPPSPSAPPPVVPKEEK-EEETAAAPPVEEGE-EQKPPA---AEELAVDTGKAEEPV 845 P PA P P EK E + AP V+ E E+KPP ++ L + KA P Sbjct: 988 PAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT 1047 Query: 846 KSECTEEAE 854 K E + + E Sbjct: 1048 KLEKSPKPE 1056 Score = 40.4 bits (93), Expect = 0.022 Identities = 112/542 (20%), Positives = 188/542 (34%), Gaps = 74/542 (13%) Query: 487 YRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLL 546 + + G +Q Q Q P P+S+ + K +KE + P E + Sbjct: 955 HSQSGPGAPMKQAPAPSQPPTSQGP-PKSTGQAPPAPAKSIPVKKETKAPAAEKLEP--- 1010 Query: 547 KEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELAS 606 K + T EK+ K K+ ++ ++ T+ E++ P+ + L Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKL-------EKSPKPESTCPLCK 1063 Query: 607 MELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFN---YKKRQNLD 663 ELN S+ T ++CKN N + +L Sbjct: 1064 TELNIGSKDPPN------------------------FNTCTECKNQVCNLCGFNPTPHLT 1099 Query: 664 EILQQHKLKMEKERNARRK----KKKAPAAASEEAAFPPVVEDEEMEASGV-------SG 712 EI + L + +R + +K PA + +A+ PV + + + V Sbjct: 1100 EIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKK 1159 Query: 713 NEEEMVEEAEAT----VNNSSDTESIPSPHTEAAKDTGQNGPKPPAT-LGADGPPPGPPT 767 E+E+ EAE V + E IP T K K A+ L P P Sbjct: 1160 QEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK 1219 Query: 768 PPPEDIPAPTEPTPASEATGAPTPPPAPPSP----SAPPP---------VVPKEEKEEET 814 PE+ +E PTP P SAP V EEK E Sbjct: 1220 LIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGR 1279 Query: 815 AAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGAL 874 A V+EG+ Q E L T ++ + T+ +E P A+ + G Sbjct: 1280 VAPKTVQEGK-QPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP-DQVEPGKE 1337 Query: 875 KAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP 934 K EK++ S +++ + SD+ S+D + + G + + + +L Sbjct: 1338 KTEKEDDKSDTSSSQQPKSPQGLSDTGY--SSDGISSSLGEIPSLIPTDEKDILKGLKKD 1395 Query: 935 RAN--ASPQKPLDLKQLKQRAAAIPPIQV-TKVHEPPREDAAPTKPAPPAPPPPQNLQPE 991 + +SP P DL +L+ +I Q T E + P + +P P + Q Sbjct: 1396 SFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSL 1455 Query: 992 SD 993 S+ Sbjct: 1456 SE 1457 Score = 38.9 bits (89), Expect = 0.063 Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 40/245 (16%) Query: 1380 PSRDLTEAYKTQALGPLKLKPAHEGLVATV-----------KEAGRSIHEIPREELR--- 1425 P +DL++A + + PL +P G + K A +P E+ + Sbjct: 690 PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749 Query: 1426 --HTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHD-----VRSLIGSPGRTFPPV 1478 P+ P +P + + K D +S S+ + +++ P ++FPP Sbjct: 750 ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT 809 Query: 1479 HPLDVMADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHG 1538 D++A+ R + + S PG +S S G + PV E K Q+ ++ + Sbjct: 810 GEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQ-KQVDPVQKKEEPKKAQTKMSPK--- 865 Query: 1539 APFAGHLPRGSP------------VTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKS 1586 P A +P+GSP V T + +P+ QE S S +T P+ + Sbjct: 866 -PDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFS--LNLGSITDAPKSQPTT 922 Query: 1587 PHSTV 1591 P TV Sbjct: 923 PQETV 927 Score = 38.5 bits (88), Expect = 0.082 Identities = 100/473 (21%), Positives = 160/473 (33%), Gaps = 56/473 (11%) Query: 1930 PKEAPRVARPERPRA-------DTGHAFLAKPPARSGLEPASS--PSKGSEPRPLVPPVS 1980 P EA +++P P+ D KP ++P + S + +P +P Sbjct: 723 PPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK 782 Query: 1981 GHATIARTPAKNLAPHHASPDPPAPPASAS-DPHREKTQSKPFSIQELELRSLGYHGSSY 2039 + L A P PP P K +P S ++ + G S Sbjct: 783 VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKI-ISHPGPSSESK 841 Query: 2040 SPEGVEPVSPVSSPSLTHDKGLPK-HLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLR 2098 + V+PV P K PK + + K P PGP G+ P Sbjct: 842 GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGS------PTPPGPRPTAGQTVPTPQQS 895 Query: 2099 PLPESQPSSSPL----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPL 2154 P P+ Q L + AP + T+ + +++ +A P P Sbjct: 896 PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGP- 954 Query: 2155 YSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIE 2214 +S G P+ P PP G P G+ P P K+ + E Sbjct: 955 HSQSGPGAPMKQAPAPSQ----PPTSQGPP------KSTGQAPPAPAKSIPVKK-----E 999 Query: 2215 PVSPPEGMTEPGHSRSAVYPLLYR-DGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAM 2273 +P EP ++ P + R + E+ P SKS Q +KL +S Sbjct: 1000 TKAPAAEKLEP---KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP- 1055 Query: 2274 VKSKKQEINKKLNTHNRNEPEYN-ISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMG 2332 +S +LN +++ P +N ++ ++ N+ T +T +QE N Sbjct: 1056 -ESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLT----EIQEWLCLNCQ 1110 Query: 2333 LEAIIRKALMGGGGKAKVSGRPSSRKAK-SPAPGLASGDR---PPSVSSVHSE 2381 + I L G K+ PS KA P P +S + PP V V + Sbjct: 1111 TQRAISGQL---GDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ 1160 Score = 35.8 bits (81), Expect = 0.53 Identities = 32/139 (23%), Positives = 47/139 (33%), Gaps = 13/139 (9%) Query: 726 NNSSDTESIPSPHTEA----------AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPA 775 +N T P PH+++ A PP + G P P P ++ A Sbjct: 943 SNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKA 1002 Query: 776 PTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELA 835 P +A APT PP K E A P + + KP + L Sbjct: 1003 PAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC 1062 Query: 836 ---VDTGKAEEPVKSECTE 851 ++ G + P + CTE Sbjct: 1063 KTELNIGSKDPPNFNTCTE 1081 Score = 34.3 bits (77), Expect = 1.6 Identities = 14/37 (37%), Positives = 30/37 (81%), Gaps = 3/37 (8%) Query: 167 LSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEE 203 +++ +++Q+ +DRE+ +VE++ +KL+KKQ +L+EE Sbjct: 3757 MARAKILQD---IDRELDLVERESAKLRKKQAELDEE 3790 >gi|150378539 piccolo isoform 1 [Homo sapiens] Length = 5142 Score = 88.6 bits (218), Expect = 7e-17 Identities = 140/668 (20%), Positives = 222/668 (33%), Gaps = 106/668 (15%) Query: 556 EDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRW 615 ++ D GR + + G + SE+ + + + ++ E + Sbjct: 85 QELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDL 144 Query: 616 TEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEK 675 EE + G L SA+ S V++ F + +E ++ K+ ++K Sbjct: 145 KEEHKSSMMPGFLSEVNALSAV-----SSVVNKFNPFDLISDSEASQEETTKKQKV-VQK 198 Query: 676 ERNARRKKKKAPAAASEEAAFP--------PVVEDEEMEASGVSGNEEEMVEEAEATVNN 727 E+ K P P P+ +D ++ +S + E ++ Sbjct: 199 EQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKS--ISSQQPEKIKSQPPGTGK 256 Query: 728 SSDTESIPSPHTEAAKDTGQNGPKPPATLGAD-----GPPPGPPTPPPEDIPAPTEPTPA 782 + +P T+ AK Q P T AD P P+P I PT P Sbjct: 257 PIQGPT-QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315 Query: 783 SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842 ++ G P P P A P + K ++ PPV+ KPPA + Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---------QPL 366 Query: 843 EPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSA 902 P K + E P+ + A A G K ++ G + T + G P+ Sbjct: 367 GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPT-QQVGTPKPLAQQP 425 Query: 903 TCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVT 962 + +A G K + P P + P A P K +Q PP Q+ Sbjct: 426 GLQSPA--KAPGPTKTPVQQPGPGKI-----PAQQAGPGKT----SAQQTGPTKPPSQLP 474 Query: 963 KVHEPPREDAAPTKPAPPAP--------------PPPQNLQPESDAPQQPGSS------- 1001 +PP + P KP P P PPPQ P +PQQPGS+ Sbjct: 475 GPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQP 534 Query: 1002 ----PRGKSRSPAPPADKEAEKPVFF---------PAFAAEAQKLPGDPPCWTSGLPFPV 1048 P + SPA P+ +++ KPV P + A++ P + GLP + Sbjct: 535 GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP------SQGLPKTI 588 Query: 1049 PPR-EVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1107 P + H P+ + F+ L NP P ++ K Sbjct: 589 CPLCNTTELLLHVPEKANFNTCTECQTTVCSLCG------------FNPNPHLTEVKEWL 636 Query: 1108 VLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRG 1167 L Q+ G VP S K PVT S + +Q SP+ Sbjct: 637 CLNCQMKRALGGDLAP--VPSSPQPKLKTAPVT--------TTSAVSKSSPQPQQTSPKK 686 Query: 1168 QAGPPESL 1175 A P + L Sbjct: 687 DAAPKQDL 694 Score = 58.2 bits (139), Expect = 1e-07 Identities = 94/438 (21%), Positives = 151/438 (34%), Gaps = 49/438 (11%) Query: 735 PSPHTEAAKDTGQNGPKPPATLGAD-GPPPGPPTPPPEDIPAPT-----EPTPASEATGA 788 P+PH K+ + LG D P P P P + P T + +P + T + Sbjct: 625 PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQT-S 683 Query: 789 PTPPPAP-------PSPSAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839 P AP P P PPP+V P A P E KP +E +V + Sbjct: 684 PKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743 Query: 840 KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 899 + + PV + ++ + ++ AT + + + K + + TT P +D Sbjct: 744 QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-----PLKTD 798 Query: 900 SSATCSADEVDEAEGGDKNRLLSPRP---SLLTPTGDPRANASPQKPLDLKQLKQRAAAI 956 S+ + + + PRP S + P + + QK +D Q K+ Sbjct: 799 SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE---- 854 Query: 957 PPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKE 1016 P TK+ P+ DA P P PP P+ ++ Q P+ +SR + Sbjct: 855 PKKAQTKMS--PKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912 Query: 1017 AEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS---PHAPDPSAFSYAPPGH 1073 + P + P P +G F +AS A P S + PG Sbjct: 913 TDAP----------KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGA 962 Query: 1074 PLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAK 1133 P+ P +PPT PP A + ++ + + P +E A Sbjct: 963 PM------KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016 Query: 1134 APVGPVTMGLPLPMDPKK 1151 T P P+ K Sbjct: 1017 TVKRTETEKKPPPIKDSK 1034 Score = 54.7 bits (130), Expect = 1e-06 Identities = 114/547 (20%), Positives = 177/547 (32%), Gaps = 75/547 (13%) Query: 1725 LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTH--LTKPTTT 1782 +S+ LP P + +M R L ++ P + S P PG P L+K TT Sbjct: 60 MSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPP---KQSGRPPDPGRPAQPGLSKSRTT 116 Query: 1783 SSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPG--TEQSSGSSGSSGGGGGSSS 1840 + E+ ++S + EH PG +E ++ S+ SS + Sbjct: 117 DTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPF 176 Query: 1841 RPASHSHAHQHSPISPRT-------------QDALQQRPS--VLHNTG-------MKGII 1878 S S A Q + + LQQ+P + G G Sbjct: 177 DLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTP 236 Query: 1879 TAVEPSTPTVLRST--STSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV 1936 ++ P ++S T P++ P H L D P + ++ E+ + Sbjct: 237 KSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP 296 Query: 1937 ARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPH 1996 + P + KPPA+ +P S+ +P P +A+ P P Sbjct: 297 SLPSPSKPPIQQPTPGKPPAQ---QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPV 353 Query: 1997 H--ASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPS 2054 + PPA P + P ++T S+ S ++ ++L +P P P Sbjct: 354 QPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP-GPAKPP- 411 Query: 2055 LTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTA 2114 T G PK L + +P P K G P P+ + P P Q Sbjct: 412 -TQQVGTPKPLAQ----------QPGLQSPAKAPG-----PTKTPVQQPGPGKIPAQQAG 455 Query: 2115 PGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDL---RRPP 2171 PG Q Q P QL P P PG + P +PP Sbjct: 456 PGKTSAQ--------------QTGPTKPPSQLPGPAKPPPQQ-PGPAKPPPQQPGSAKPP 500 Query: 2172 SDL---YLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHS 2228 S PPP PA+ SP G + P S + + T+P Sbjct: 501 SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560 Query: 2229 RSAVYPL 2235 + PL Sbjct: 561 TGSGKPL 567 Score = 49.3 bits (116), Expect = 5e-05 Identities = 95/391 (24%), Positives = 139/391 (35%), Gaps = 80/391 (20%) Query: 840 KAEEPVKSECTEE---AEEGPAKGKDAEAAEATAEGALKA--EKKEGGSGRATTAKSSGA 894 K E PV + + +E+ P K E L+A +KKE + R ++ S Sbjct: 2280 KPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETV 2339 Query: 895 PQDSDSS--ATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 952 SS A +++ +P+ P+G P ++ P KP + Sbjct: 2340 FDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSL 2399 Query: 953 AAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR-----GKSR 1007 + P PP P PP PPPP P P P +SP+ K Sbjct: 2400 DISAQP--------PP--------PPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKL 2443 Query: 1008 SPAPPADKEAEKPVFFPAFAAE------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAP 1061 + A P P+F E + LP C T+ P PVPP+ Sbjct: 2444 TVASPV--TTATPLFDAVTTLETTAVLRSNGLPVTRICTTA--PPPVPPK---------- 2489 Query: 1062 DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP--PPLISSAKHPSVLERQIGAISQG 1119 PS+ +P GL T RP +PP P P L ++ + P+ + + +S Sbjct: 2490 -PSS---------IPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLT 2539 Query: 1120 MSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPR-----GQAGPPES 1174 S+ L++ S K LP P P L+P S + S P Sbjct: 2540 SSMTLNLVTSADYK---------LPSPTSP--LSPHSNKSSPRFSKSLTETYVVITLPSE 2588 Query: 1175 LGVPTAQEASVLRGTALGSVPGGSITKGIPS 1205 G PT AS A+ S P GS +K + S Sbjct: 2589 PGTPTDSSAS----QAITSWPLGSPSKDLVS 2615 Score = 46.2 bits (108), Expect = 4e-04 Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 21/66 (31%) Query: 756 LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE---EKEE 812 + A PPP PP PPP P PPP PP P PPP PK K++ Sbjct: 2401 ISAQPPPPPPPPPPP------------------PPPPPPPPPPPLPPPTSPKPTILPKKK 2442 Query: 813 ETAAAP 818 T A+P Sbjct: 2443 LTVASP 2448 Score = 45.8 bits (107), Expect = 5e-04 Identities = 85/467 (18%), Positives = 182/467 (38%), Gaps = 64/467 (13%) Query: 183 ITMVEQQISKLKKKQQQLEEEAAKPPE--PEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240 ++++E Q S L ++ E+ +P E PE+P +S +L I +E K+++ Sbjct: 1417 LSILEAQASTLADEKS---EKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473 Query: 241 AHRILEGLGPQVELP----------LYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHA 290 + Q ++P + + R+ +++++ + + KRR Sbjct: 1474 ERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSV 1533 Query: 291 RKQWEQKFCQRYDQLMEAWEKKVER--IENNPRRRAKESKVREYYEKQFPEIRKQRELQE 348 ++ Q Q E + + IE + A S+ E+ Q EI E Q+ Sbjct: 1534 GSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQK 1593 Query: 349 RMQSR-------------VGQRGSGLSMSAAR------SEHEVSEIIDGLSEQENLEKQM 389 + +++ + + + A R + E + L +E ++ Sbjct: 1594 KEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES 1653 Query: 390 RQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHP- 448 +L V +R K I +N +AD ++ +++ ++E E E P Sbjct: 1654 EELVVTG----GGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPE 1709 Query: 449 -KNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQ 507 ++ G +S L + ++ +E+ S K + +QQ++ + + Sbjct: 1710 DRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHK-----KGESKQQRKARHRPHG 1764 Query: 508 QQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASK 567 P S EE++ +E+E+ +++E++ E+E + ++ + S +D DE A Sbjct: 1765 PLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQ----RKSSSKKSKKDKDELRA---- 1816 Query: 568 GRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASM-ELNESS 613 RR+ R +N + E+A ++ + A M EL+ SS Sbjct: 1817 --------QRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSS 1855 Score = 45.1 bits (105), Expect = 9e-04 Identities = 69/321 (21%), Positives = 105/321 (32%), Gaps = 72/321 (22%) Query: 708 SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAK-DTGQNGPKPPATLGADGPPPGPP 766 SG + +E+ + + + S + P P ++ D P PP PPP PP Sbjct: 2363 SGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPP--PPPPPPPPP 2420 Query: 767 TPPPEDIPAPTEPTP----------ASEATGA---------------------------- 788 PPP +P PT P P AS T A Sbjct: 2421 PPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICT 2480 Query: 789 PTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEE----P 844 PPP PP PS+ P + + E + PP+ P +L T K + P Sbjct: 2481 TAPPPVPPKPSSIPSGLVFTHRPE--PSKPPI-----APKPVIPQLPTTTQKPTDIHPKP 2533 Query: 845 VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRA--------TTAKSSGAPQ 896 T D + T+ + + K ++ T G P Sbjct: 2534 TGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPT 2593 Query: 897 DSDSSATCSADEVDEAEGGDKNRLLSPRP--SLLTPTGDPRANASPQKPLDLKQLKQRAA 954 DS +S ++ + G L+S P S++ P + + P+ +Q + Sbjct: 2594 DSSASQAITSWPL----GSPSKDLVSVEPVFSVVPPV------TAVEIPISSEQTFYISG 2643 Query: 955 AIPPIQVTKVHEPPREDAAPT 975 A+ T V P AAPT Sbjct: 2644 ALQTFSATPVTAPSSFQAAPT 2664 Score = 43.9 bits (102), Expect = 0.002 Identities = 51/241 (21%), Positives = 92/241 (38%), Gaps = 29/241 (12%) Query: 792 PPAPPSPSAPPPVVPKEEKEEETAAAPP---VEEGEEQKPPAAEELAVDTGK---AEEPV 845 PPAP P A P VP E ++TA P V++ E++ AE++ ++ K + E + Sbjct: 1126 PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKI 1185 Query: 846 KSECTEEAEEGPAKGKDAEAAEATAEGALKAEKK--------EGGSGRATTAKSSGAPQD 897 T + ++ +K + +A+ + L EKK + + P+D Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPED 1245 Query: 898 SDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIP 957 +E K+ LL + + + R +P+ + KQ + + +P Sbjct: 1246 KKLLPEAKTSAPEE----QKHDLLKSQVQIAEEKLEGR--VAPKTVQEGKQPQTKMEGLP 1299 Query: 958 PIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPRGKSRSPAP 1011 + P+ED TK P PP +P+ P ++ S S+ P Sbjct: 1300 SGTPQSL---PKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKS 1356 Query: 1012 P 1012 P Sbjct: 1357 P 1357 Score = 42.7 bits (99), Expect = 0.004 Identities = 93/443 (20%), Positives = 149/443 (33%), Gaps = 71/443 (16%) Query: 770 PEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPP 829 PE + A + G+P+ P A + +EE+ + A + + P Sbjct: 13 PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72 Query: 830 AAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE---AAEATAEGALKAEKKEGGSGRA 886 A + + +E S +++ P G+ A+ + T + +K G S Sbjct: 73 PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132 Query: 887 TTAKSSGAPQDSDSSATCS-----ADEVD--EAEGGDKNRLLSPRPSLLTPTGDPRANAS 939 + K S + D S EV+ A N+ +P + Sbjct: 133 ISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNK-FNPFDLISDSEASQEETTK 191 Query: 940 PQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQP- 998 QK + +Q K PP+Q +PP+ P + P P Q+ P+S + QQP Sbjct: 192 KQKVVQKEQGKPEGIIKPPLQ----QQPPK--PIPKQQGPGRDPLQQDGTPKSISSQQPE 245 Query: 999 ---------GSSPRGKSRSPAP-----PADKEAEKPVFFPAFAAEAQKL------PGDPP 1038 G +G +++P P ++A +P A + + P PP Sbjct: 246 KIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP 305 Query: 1039 CWTSGLPFP-VPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH-DTARPVLPRPPTISNP 1096 P P PP + P P+ P G PL T +P + P T P Sbjct: 306 IQQ---PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPP 362 Query: 1097 PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFS 1156 + AK P+ +Q G+ P SE PK LA Sbjct: 363 AQPLGPAKPPA---QQTGS---------EKPSSEQP---------------GPKALAQPP 395 Query: 1157 GVKQEQLSPRGQAGPP-ESLGVP 1178 GV + G A PP + +G P Sbjct: 396 GVGKTPAQQPGPAKPPTQQVGTP 418 Score = 42.7 bits (99), Expect = 0.004 Identities = 70/346 (20%), Positives = 112/346 (32%), Gaps = 57/346 (16%) Query: 734 IPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPP 793 + P + P +L PP P P +D + P PT Sbjct: 707 VKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDL 766 Query: 794 APPSPSAPPPVVP--KEEKEEETAAAPPVE----EGEEQKPPAAEELAVDTGKAEEPVKS 847 S + P +P K + + E PP++ + + PP E+++ KA S Sbjct: 767 VSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPAS 826 Query: 848 ECTEEAEEGP---AKG--------KDAEAAEATAEGALKAEKKEGGSGRAT--------- 887 + + GP +KG K E +A + + K + K G T Sbjct: 827 DSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAG 886 Query: 888 ----TAKSSGAPQDSD---------------SSATCSADEVDEAEGGDKNRLLSPRPSLL 928 T + S PQ+ S T + V G + S +L+ Sbjct: 887 QTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI 946 Query: 929 TPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNL 988 + G P ++ +KQ A P Q PP+ T APPAP + Sbjct: 947 STAGQPGPHSQSGPGAPMKQ------APAPSQPPTSQGPPKS----TGQAPPAPAKSIPV 996 Query: 989 QPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVF--FPAFAAEAQK 1032 + E+ AP P+ + + E + P + AE QK Sbjct: 997 KKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQK 1042 Score = 40.4 bits (93), Expect = 0.022 Identities = 78/369 (21%), Positives = 132/369 (35%), Gaps = 56/369 (15%) Query: 509 QQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKED---LLKEKTDDTSGEDNDEKEAVA 565 +QP P + K KE E++K V +DK ++K TD S K + Sbjct: 721 KQP-PEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIP 779 Query: 566 SKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKK 625 S ++ +EE TP + S + ++S T E++ Sbjct: 780 SS-------------------KVQSQAEEKTTPPLKTD--SAKPSQSFPPTGEKVSPFDS 818 Query: 626 GLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKK 685 + + S I G + S+ + +K++ ++ + KM + +A+ K Sbjct: 819 KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEP----KKAQTKMSPKPDAKPMPKG 874 Query: 686 APA------AASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDT-------- 731 +P A + P + ++ S N + + ++ +T Sbjct: 875 SPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGF 934 Query: 732 -ESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPT 790 SI S + GQ GP + GA P+ PP P ++TG Sbjct: 935 GASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPP-------KSTGQAP 987 Query: 791 PPPAPPSPSAPPPVVPKEEK-EEETAAAPPVEEGE-EQKPPA---AEELAVDTGKAEEPV 845 P PA P P EK E + AP V+ E E+KPP ++ L + KA P Sbjct: 988 PAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT 1047 Query: 846 KSECTEEAE 854 K E + + E Sbjct: 1048 KLEKSPKPE 1056 Score = 40.4 bits (93), Expect = 0.022 Identities = 112/542 (20%), Positives = 188/542 (34%), Gaps = 74/542 (13%) Query: 487 YRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLL 546 + + G +Q Q Q P P+S+ + K +KE + P E + Sbjct: 955 HSQSGPGAPMKQAPAPSQPPTSQGP-PKSTGQAPPAPAKSIPVKKETKAPAAEKLEP--- 1010 Query: 547 KEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELAS 606 K + T EK+ K K+ ++ ++ T+ E++ P+ + L Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKL-------EKSPKPESTCPLCK 1063 Query: 607 MELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFN---YKKRQNLD 663 ELN S+ T ++CKN N + +L Sbjct: 1064 TELNIGSKDPPN------------------------FNTCTECKNQVCNLCGFNPTPHLT 1099 Query: 664 EILQQHKLKMEKERNARRK----KKKAPAAASEEAAFPPVVEDEEMEASGV-------SG 712 EI + L + +R + +K PA + +A+ PV + + + V Sbjct: 1100 EIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKK 1159 Query: 713 NEEEMVEEAEAT----VNNSSDTESIPSPHTEAAKDTGQNGPKPPAT-LGADGPPPGPPT 767 E+E+ EAE V + E IP T K K A+ L P P Sbjct: 1160 QEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK 1219 Query: 768 PPPEDIPAPTEPTPASEATGAPTPPPAPPSP----SAPPP---------VVPKEEKEEET 814 PE+ +E PTP P SAP V EEK E Sbjct: 1220 LIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGR 1279 Query: 815 AAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGAL 874 A V+EG+ Q E L T ++ + T+ +E P A+ + G Sbjct: 1280 VAPKTVQEGK-QPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP-DQVEPGKE 1337 Query: 875 KAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP 934 K EK++ S +++ + SD+ S+D + + G + + + +L Sbjct: 1338 KTEKEDDKSDTSSSQQPKSPQGLSDTGY--SSDGISSSLGEIPSLIPTDEKDILKGLKKD 1395 Query: 935 RAN--ASPQKPLDLKQLKQRAAAIPPIQV-TKVHEPPREDAAPTKPAPPAPPPPQNLQPE 991 + +SP P DL +L+ +I Q T E + P + +P P + Q Sbjct: 1396 SFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSL 1455 Query: 992 SD 993 S+ Sbjct: 1456 SE 1457 Score = 38.9 bits (89), Expect = 0.063 Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 40/245 (16%) Query: 1380 PSRDLTEAYKTQALGPLKLKPAHEGLVATV-----------KEAGRSIHEIPREELR--- 1425 P +DL++A + + PL +P G + K A +P E+ + Sbjct: 690 PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749 Query: 1426 --HTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHD-----VRSLIGSPGRTFPPV 1478 P+ P +P + + K D +S S+ + +++ P ++FPP Sbjct: 750 ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT 809 Query: 1479 HPLDVMADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHG 1538 D++A+ R + + S PG +S S G + PV E K Q+ ++ + Sbjct: 810 GEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQ-KQVDPVQKKEEPKKAQTKMSPK--- 865 Query: 1539 APFAGHLPRGSP------------VTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKS 1586 P A +P+GSP V T + +P+ QE S S +T P+ + Sbjct: 866 -PDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFS--LNLGSITDAPKSQPTT 922 Query: 1587 PHSTV 1591 P TV Sbjct: 923 PQETV 927 Score = 38.5 bits (88), Expect = 0.082 Identities = 100/473 (21%), Positives = 160/473 (33%), Gaps = 56/473 (11%) Query: 1930 PKEAPRVARPERPRA-------DTGHAFLAKPPARSGLEPASS--PSKGSEPRPLVPPVS 1980 P EA +++P P+ D KP ++P + S + +P +P Sbjct: 723 PPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK 782 Query: 1981 GHATIARTPAKNLAPHHASPDPPAPPASAS-DPHREKTQSKPFSIQELELRSLGYHGSSY 2039 + L A P PP P K +P S ++ + G S Sbjct: 783 VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKI-ISHPGPSSESK 841 Query: 2040 SPEGVEPVSPVSSPSLTHDKGLPK-HLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLR 2098 + V+PV P K PK + + K P PGP G+ P Sbjct: 842 GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGS------PTPPGPRPTAGQTVPTPQQS 895 Query: 2099 PLPESQPSSSPL----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPL 2154 P P+ Q L + AP + T+ + +++ +A P P Sbjct: 896 PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGP- 954 Query: 2155 YSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIE 2214 +S G P+ P PP G P G+ P P K+ + E Sbjct: 955 HSQSGPGAPMKQAPAPSQ----PPTSQGPP------KSTGQAPPAPAKSIPVKK-----E 999 Query: 2215 PVSPPEGMTEPGHSRSAVYPLLYR-DGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAM 2273 +P EP ++ P + R + E+ P SKS Q +KL +S Sbjct: 1000 TKAPAAEKLEP---KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP- 1055 Query: 2274 VKSKKQEINKKLNTHNRNEPEYN-ISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMG 2332 +S +LN +++ P +N ++ ++ N+ T +T +QE N Sbjct: 1056 -ESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLT----EIQEWLCLNCQ 1110 Query: 2333 LEAIIRKALMGGGGKAKVSGRPSSRKAK-SPAPGLASGDR---PPSVSSVHSE 2381 + I L G K+ PS KA P P +S + PP V V + Sbjct: 1111 TQRAISGQL---GDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ 1160 Score = 35.8 bits (81), Expect = 0.53 Identities = 32/139 (23%), Positives = 47/139 (33%), Gaps = 13/139 (9%) Query: 726 NNSSDTESIPSPHTEA----------AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPA 775 +N T P PH+++ A PP + G P P P ++ A Sbjct: 943 SNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKA 1002 Query: 776 PTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELA 835 P +A APT PP K E A P + + KP + L Sbjct: 1003 PAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC 1062 Query: 836 ---VDTGKAEEPVKSECTE 851 ++ G + P + CTE Sbjct: 1063 KTELNIGSKDPPNFNTCTE 1081 Score = 34.3 bits (77), Expect = 1.6 Identities = 14/37 (37%), Positives = 30/37 (81%), Gaps = 3/37 (8%) Query: 167 LSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEE 203 +++ +++Q+ +DRE+ +VE++ +KL+KKQ +L+EE Sbjct: 3757 MARAKILQD---IDRELDLVERESAKLRKKQAELDEE 3790 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 87.8 bits (216), Expect = 1e-16 Identities = 129/555 (23%), Positives = 199/555 (35%), Gaps = 71/555 (12%) Query: 683 KKKAPAAASEEAAFPPVVEDEEMEAS--------GVSGNEEEMVEEAEATVNNSSDTESI 734 +KK P ++ PP E +A+ + E E + + Sbjct: 10535 EKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKV 10594 Query: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPA 794 P+ + + T P+ P + + P PP PE P P P Sbjct: 10595 PAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAI 10654 Query: 795 PPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK--AEEPVKSECTEE 852 PP P +PPP V EE EE PP E EE +P A ++ V K E+ + ++ Sbjct: 10655 PPKPESPPPEV-FEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKK 10713 Query: 853 AEEGPAKGKDA--EAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 910 E P K + E + +K E + P+ A EV Sbjct: 10714 PELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPE--KKVAVPKKPEVP 10771 Query: 911 EAEGGD--KNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968 A+ + K +L +P++ P RA + P + + + I P + V P Sbjct: 10772 PAKVPEVPKKPVLEEKPAVPVP---ERAESPPPEVYEEPEEIAPEEEIAPEEEKPV--PV 10826 Query: 969 REDAAPTKPAPPAPPPPQNL----------QPESDAPQQPG-----SSPRGKSRSPAPP- 1012 E+ P P P P P+ + +PE+ P++P P+ K R P PP Sbjct: 10827 AEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPP 10886 Query: 1013 -ADKEAEKPVFFPAFAAEAQKLPGDP--PCWTSGLPFPVP--PREVIKASP-HAPDP--- 1063 KE K F A +K+P P P P VP ++V K P P+P Sbjct: 10887 APPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEE 10946 Query: 1064 ----SAFSYAPPGHP---LPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVL--ERQIG 1114 S P P L +P +P PP PP + + P+V ER+I Sbjct: 10947 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPP----PPKPVEEVEVPTVTKRERKIP 11002 Query: 1115 AISQGMSVQ--LHVPYSEHAKAPVGPVTMGLPLPMDPKK-------LAPFSGVKQEQLSP 1165 ++ ++ + +P E P V P P++P+ P G K E +P Sbjct: 11003 EPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAP 11062 Query: 1166 RGQAGPPES--LGVP 1178 + +A P+ GVP Sbjct: 11063 KEEAAKPKGPIKGVP 11077 Score = 77.0 bits (188), Expect = 2e-13 Identities = 143/691 (20%), Positives = 240/691 (34%), Gaps = 104/691 (15%) Query: 507 QQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVAS 566 ++++ +P EE +E E E E EE P +E + E++ + + K+AV Sbjct: 10228 KEEEVLPVEVTEEPEE-EPISEEEIPEEPPSIE-EVEEVAPPRVPEVI------KKAVPE 10279 Query: 567 KGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNE-SSRWTEEEMETAKK 625 ++++ + E + P Q E ++ E + E+++ KK Sbjct: 10280 APTPVPKKVEAPPAKVSKKIPEE----KVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKK 10335 Query: 626 GLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKK 685 + + + + V +++ + E L+ ++ E E ++ Sbjct: 10336 EAVPPAKGRTVLEEKVSVA-----------FRQEVVVKERLELEVVEAEVEEIPEEEEFH 10384 Query: 686 APAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVN--NSSDTESIPSPHTEAAK 743 EE F V E ++E V EE VE+ + + + E P Sbjct: 10385 EVEEYFEEGEFHEVEEFIKLEQHRVE--EEHRVEKVHRVIEVFEAEEVEVFEKPKAP--- 10439 Query: 744 DTGQNGPKPPATLGADGPPPGPPTP------PPEDIPAPTEPTPASEATGAPTPPPAPPS 797 PK P PP PPT PP +P + E P P PP+ Sbjct: 10440 ------PKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPT 10493 Query: 798 PSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGP 857 P + PKE E+ PP ++ E P E + + PV ++ E P Sbjct: 10494 -KVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPP--KKPEVPP 10550 Query: 858 AKGKDAEAAEATAEGALKA--EKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGG 915 K + A + +A K E A P+ +A EV + Sbjct: 10551 TKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVP 10610 Query: 916 DKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPI---QVTKVHEPPREDA 972 + + + P + P P+KP +PP +V KV P ++ Sbjct: 10611 EAPKEVVPEKKVPVPP--------PKKP-----------EVPPTKVPEVPKVAVPEKKVP 10651 Query: 973 APTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPP-ADKEAEKPVFFPAFAAEAQ 1031 P P +PPP +PE A ++P + + APP +KPV A Sbjct: 10652 EAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVA 10711 Query: 1032 KLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPP 1091 K P PP + P P+EV+ P +PL V+P+ P Sbjct: 10712 KKPELPP-----VKVPEVPKEVV----------------PEKKVPL--------VVPKKP 10742 Query: 1092 TISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKK 1151 PP + V E+++ + VP E K PV +P+P + Sbjct: 10743 EA--PPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVP--EVPKKPVLEEKPAVPVPERAES 10798 Query: 1152 LAPFSGVKQEQLSPRGQAGPPESLGVPTAQE 1182 P + E+++P + P E VP A+E Sbjct: 10799 PPPEVYEEPEEIAPEEEIAPEEEKPVPVAEE 10829 Score = 75.9 bits (185), Expect = 5e-13 Identities = 123/530 (23%), Positives = 190/530 (35%), Gaps = 63/530 (11%) Query: 653 YFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSG 712 YF + ++E ++ + ++E+E + + +EE V E + G Sbjct: 10389 YFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVE---VFEKPKAPPKGPEI 10445 Query: 713 NEEEMVEEAEAT--VNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPP 770 +E+ + + T V +P + + P+ P PPT P Sbjct: 10446 SEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRV---------PPTKVP 10496 Query: 771 EDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKE---EETAAAPPVEEGE--E 825 E +P P E P + P P P APPP VP+ KE E+ PP ++ E Sbjct: 10497 EVLP-PKEVVPEKKV-----PVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPP 10550 Query: 826 QKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGR 885 K P + AV K E + + E P K E A +K E + Sbjct: 10551 TKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPK--EVVPEKKVPAAPPKKPEVTPVK 10608 Query: 886 ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD 945 A P+ EV + + ++ P + P P SP P Sbjct: 10609 VPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKV--PEAIPPKPESP-PPEV 10665 Query: 946 LKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR-G 1004 ++ ++ A PP +V V EP E AAP P PP+ PE AP P Sbjct: 10666 FEEPEEVALEEPPAEV--VEEP--EPAAP----PQVTVPPKKPVPEKKAPAVVAKKPELP 10717 Query: 1005 KSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD-P 1063 + P P + EK V K P PP +P V P + + A P P+ P Sbjct: 10718 PVKVPEVPKEVVPEKKV-----PLVVPKKPEAPPAKVPEVPKEVVPEKKV-AVPKKPEVP 10771 Query: 1064 SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ 1123 A P P+ +P +P P +PPP + E +I + Sbjct: 10772 PAKVPEVPKKPVL-----EEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAP-----EEE 10821 Query: 1124 LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPE 1173 VP +E + V P +P +PKK+ P K+ + + +A PP+ Sbjct: 10822 KPVPVAEEEEPEVPPPA----VPEEPKKIIP---EKKVPVIKKPEAPPPK 10864 Score = 75.9 bits (185), Expect = 5e-13 Identities = 122/522 (23%), Positives = 176/522 (33%), Gaps = 95/522 (18%) Query: 692 EEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPK 751 EE PP E + +E+V E + V + E+ P EA K+ Sbjct: 10486 EEPRVPPTKVPEVLPP-------KEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKV 10538 Query: 752 PPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEK- 810 P PPP P PP +P P + P PP P +PPP VP+ K Sbjct: 10539 PV-------PPPKKPEVPPTKVPE----VPKAAVPEKKVPEAIPPKPESPPPEVPEAPKE 10587 Query: 811 ---EEETAAAPPVE-EGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAA 866 E++ AAPP + E K P A + V K P + + P K A Sbjct: 10588 VVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPE 10647 Query: 867 EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 926 + E K E A ++ A+ V+E E Sbjct: 10648 KKVPEAI--PPKPESPPPEVFEEPEEVALEEP------PAEVVEEPE------------- 10686 Query: 927 LLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQ 986 P P+ P+KP+ K+ A P + KV E P+E P K P Sbjct: 10687 ---PAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKE-VVPEKKVPLV----- 10737 Query: 987 NLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPF 1046 P++P + P ++ P P + EK V P K P PP Sbjct: 10738 -------VPKKPEAPP---AKVPEVPKEVVPEKKVAVP-------KKPEVPPAKVP---- 10776 Query: 1047 PVPPREVIKASPHAPDPSAFSYAPP---GHPLPLGLHDTARPVLPRPPTISN------PP 1097 VP + V++ P P P PP P + + P +P ++ PP Sbjct: 10777 EVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPP 10836 Query: 1098 PLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSG 1157 P + + E+++ I + + P E V P P P P Sbjct: 10837 PAVPEEPKKIIPEKKVPVIKKPEA----PPPKEPEPEKVIEKPKLKPRPPPPPPAPPKED 10892 Query: 1158 VKQE--QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGG 1197 VK++ QL + PE VP E + L+ VPGG Sbjct: 10893 VKEKIFQLKAIPKKKVPEKPQVPEKVELTPLK------VPGG 10928 Score = 66.2 bits (160), Expect = 4e-10 Identities = 128/633 (20%), Positives = 231/633 (36%), Gaps = 88/633 (13%) Query: 470 YYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEA 529 Y T++ + Y+ R Y R ++ ++ + ++P+P E+ K K Sbjct: 9759 YEPTEEYDQYEEYEEREYER--------YEEHEEYITEPEKPIPVKPVPEEPVPTKPKAP 9810 Query: 530 EKEEEKPEVENDKEDL-LKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMAN 588 + K V +K + + +K + +E + V + + + ++ R K ++T A Sbjct: 9811 PAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITK-REKEQVTEPAAK 9869 Query: 589 EANSEEAITPQQSAELASMELNESSRWTE--EEMETAKKGLLEHGRNWSAIARMVGSKTV 646 + + ++ + E+ R E +E+E + E + V V Sbjct: 9870 VPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEE------VVTHVEEYLV 9923 Query: 647 SQCKNFYFNYKKRQNLDEILQQHKLKM----------EKERNARRKKKKAPAAASEEAAF 696 + + + ++ +E++ +K+ EK+ KKK+AP A E Sbjct: 9924 EEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPK 9983 Query: 697 PP-------VVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNG 749 P + + E+ + V ++ V E + V E+ P+ E K Sbjct: 9984 KPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEK 10043 Query: 750 PKP-PATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPV---V 805 P PA + PP P P + IP +PTP + AP PP P P PV + Sbjct: 10044 KVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAP--PPKVPKKREPVPVPVAL 10101 Query: 806 PKEEK---EEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD 862 P+EE+ EEE V EE+ P EE+ + + + EE E P + Sbjct: 10102 PQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYV 10161 Query: 863 AEAAEATAEGALKAEKKEGGSGRA--------TTAKSSGAPQDSDSSATCSADEVDEAEG 914 E E E + E K A T K P+ ++ + + E Sbjct: 10162 PEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVE- 10220 Query: 915 GDKNRLLSPRPSLLTP---TGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRED 971 + R++ P+ + P T +P ++P+ +++ + P I+ + PPR Sbjct: 10221 --EKRIILPKEEEVLPVEVTEEPE-----EEPISEEEIPEEP---PSIEEVEEVAPPRVP 10270 Query: 972 AAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQ 1031 K P AP P + + +AP S + + P P KEA Sbjct: 10271 EVIKKAVPEAPTP---VPKKVEAPPAKVSKKIPEEKVPVPVQKKEA-------------- 10313 Query: 1032 KLPGDPPCWTSGLPFPVPPREVIKASPHAPDPS 1064 PP +P VP ++V+ A P+ Sbjct: 10314 -----PPAKVPEVPKKVPEKKVLVPKKEAVPPA 10341 Score = 64.7 bits (156), Expect = 1e-09 Identities = 215/1079 (19%), Positives = 370/1079 (34%), Gaps = 162/1079 (15%) Query: 434 EQEKETFREKFMQ-HPKNFGLIASF------LERKTVAECVLYYYLTKKNENYKSLVRRS 486 ++EKE EK H + I SF LE + E Y + +E+Y+ + + Sbjct: 9049 QKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEI--KV 9106 Query: 487 YRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEA-EKEEEKPEVENDKEDL 545 ++ ++ ++ ++ Q+ +++ +EE +E +E+E + ++E E ++++ Sbjct: 9107 EAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVP 9166 Query: 546 LKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELA 605 K K+ V K KT+ K ++T+ + I PQ+ + Sbjct: 9167 AKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKV----PEVSKKIVPQKPSRTP 9222 Query: 606 SMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKN-------FYFNYKK 658 E E + T K + E +++ S TV + + + K Sbjct: 9223 VQE--EVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISK 9280 Query: 659 RQNLDEILQQHKLKMEKERNAR---RKKKKAPAAASEEAAFPPVVED---------EEME 706 R + + K E A KK + PA E PV E+ E Sbjct: 9281 RVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAA 9340 Query: 707 ASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP 766 V ++ V E + V + E+ P+ E K T + PPP P Sbjct: 9341 PPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVP 9400 Query: 767 TPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQ 826 P + +P +P P E P PP P P P P EEK A PV ++ Sbjct: 9401 EIPKKKVPEERKPVPRKEEE-VPPPPKVPALPKKPVP----EEK-----VAVPVPVAKKA 9450 Query: 827 KPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALK-AEKKEGGSGR 885 PP AE V E + E+ + + E +AE +E++EG S Sbjct: 9451 PPPRAE---VSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSIS 9507 Query: 886 ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD 945 + ++++ + +E +E +K ++S R +P + Sbjct: 9508 VYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVE--------------AEPAE 9553 Query: 946 LKQLKQRAAAIPPIQVTKVHEPP--REDAAPTKPAP----PAPPPPQNLQPESDAPQQPG 999 + + +++ + P K+ EPP + AP K P PAP P + P P++P Sbjct: 9554 VTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPK 9613 Query: 1000 SSPRGKSRSPAPPADKEAEKPVFFPAFAAEA-QKLPGDPPCWTSGLPFPVPPREVIKASP 1058 K PP + E+P+ PA E ++ + + PP+ + P Sbjct: 9614 KPVPEKK---VPPKVIKMEEPL--PAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEP 9668 Query: 1059 H--APDPSAFSYAPPGHPLPLG--LHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIG 1114 P+ P P R V +I P K +++E + Sbjct: 9669 KRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKER 9728 Query: 1115 AIS---QGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQ----EQLSPRG 1167 A + + +SVQ Y E+ + D K+ + ++ E+ R Sbjct: 9729 AYTLEEEAVSVQREEEYEEYEE-------------YDYKEFEEYEPTEEYDQYEEYEERE 9775 Query: 1168 QAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPAD 1227 E T E K IP VP + T PA Sbjct: 9776 YERYEEHEEYITEPE------------------KPIPVKPVPEEPVPTK----PKAPPAK 9813 Query: 1228 VLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRS 1287 VL K + P +L P V E KK V + +S+T+ KE Sbjct: 9814 VLKKAVPEEKVPVPIPKKL------KPPPPKVPEEPKK--VFEEKIRISITKREKE---- 9861 Query: 1288 SSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPER--HSPHHLK-EQHHIRG 1344 + P M RV ++ + PP R P L+ E+ Sbjct: 9862 ------QVTEPAAKVPMKPKRV---VAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEE 9912 Query: 1345 SITQGIPRSYVEAQEDYLRREAKLLKREGTPP------PPPPSRDLTEAYKTQALGPLKL 1398 + + VE +E+Y+ E + + E P P P + + E K P+ + Sbjct: 9913 EVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKK-----PVPV 9967 Query: 1399 KPAHEGLVATVKEAGRSIHE-----IPREELRHTPELPLAP-RPLKEGSITQGTPLKYD 1451 E A V E + E IP++E ++P P +P+ E + P K + Sbjct: 9968 PKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVE 10026 Score = 61.2 bits (147), Expect = 1e-08 Identities = 205/1021 (20%), Positives = 338/1021 (33%), Gaps = 158/1021 (15%) Query: 670 KLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSS 729 K K+ +++ KK++AP A E P VE++ + + EEE++ V + Sbjct: 10191 KKKVTEKKVVIPKKEEAPPAKVPEV--PKKVEEKRI----ILPKEEEVLP-----VEVTE 10239 Query: 730 DTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAP 789 + E P E P P E++ P P +A Sbjct: 10240 EPEEEPISEEEI-------------------PEEPPSIEEVEEVAPPRVPEVIKKAV-PE 10279 Query: 790 TPPPAPPSPSAPPPVVPKEEKEEETAA------APPVEEGEEQKPPAAEELAVDTGKAEE 843 P P P APP V K+ EE+ APP + E K +++ V +A Sbjct: 10280 APTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVP 10339 Query: 844 PVKSECTEEAEEGPAKGKDAEAAEATAEGALKAE----KKEGGSGRATTAKSSGAPQDSD 899 P K E + A ++ E ++AE +E G + + Sbjct: 10340 PAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVE 10399 Query: 900 SSATCSADEVDEAEGGDK-NRLLSPRPS-----LLTPTGDPRANASPQKPLDLKQLKQRA 953 V+E +K +R++ + P P+ +K + K+ Sbjct: 10400 EFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKK----- 10454 Query: 954 AAIPPIQVTKVHEPP-------------REDAAPTKPAPPAPPPPQNLQPESDAPQQPGS 1000 PP +V EPP + P +P P P+ L P+ P++ Sbjct: 10455 ---PPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVP 10511 Query: 1001 SPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS-PH 1059 P K PP EA K V +K+P PP P VP EV KA+ P Sbjct: 10512 VPPAKKPEAPPPKVPEAPKEV------VPEKKVPVPPPKKPEVPPTKVP--EVPKAAVPE 10563 Query: 1060 APDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQG 1119 P A P P + + + V+P + PP K P V ++ + Sbjct: 10564 KKVPEAIPPKPESPPPE--VPEAPKEVVPEKKVPAAPP------KKPEVTPVKVPEAPKE 10615 Query: 1120 MSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVP- 1178 + + VP K V P +P PK P V E + P+ ++ PPE P Sbjct: 10616 VVPEKKVPVPPPKKPEVPPT----KVPEVPKVAVPEKKV-PEAIPPKPESPPPEVFEEPE 10670 Query: 1179 ----TAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSI----THGTPADVLY 1230 A V+ + P ++ P + + + + + P +V+ Sbjct: 10671 EVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVP 10730 Query: 1231 KGTITRII---GEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRS 1287 + + ++ E P+++ ++ +P+ V KK V + + E+ + Sbjct: 10731 EKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVP-KKPEVPPAKVPEVPKKPVLEEKPA 10789 Query: 1288 SSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSIT 1347 P + P Y+ E E I PE P + E+ Sbjct: 10790 VPVPERAESPPPEVYEEPE------------EIAPEEEIAPEEEKPVPVAEEEE------ 10831 Query: 1348 QGIPRSYVEAQEDYLRREAK--LLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGL 1405 +P V + + E K ++K+ PPP P + + + L P P Sbjct: 10832 PEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPE--KVIEKPKLKPRPPPPPPAPP 10889 Query: 1406 VATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTPLKYDTGASTT-------- 1457 VKE + IP++++ P++P + TPLK G Sbjct: 10890 KEDVKEKIFQLKAIPKKKVPEKPQVP---------EKVELTPLKVPGGEKKVRKLLPERK 10940 Query: 1458 GSKKHDV--RSLIGS-PGRTFPPVHPLDVMADARALERACYEESLKSRP------GTASS 1508 K +V +S++ P P V P + +++ E +P T + Sbjct: 10941 PEPKEEVVLKSVLRKRPEEEEPKVEPKKL----EKVKKPAVPEPPPPKPVEEVEVPTVTK 10996 Query: 1509 SGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRLQEGSLSSS 1568 I P VPE+ KP E P A P EPTP ++ Sbjct: 10997 RERKIPE--PTKVPEI-KPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVV 11053 Query: 1569 KASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSI 1628 + K K P VP+ P PI LR SG + P + ++ Sbjct: 11054 GKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAV 11113 Query: 1629 P 1629 P Sbjct: 11114 P 11114 Score = 49.3 bits (116), Expect = 5e-05 Identities = 150/764 (19%), Positives = 262/764 (34%), Gaps = 145/764 (18%) Query: 507 QQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEA--V 564 ++++P P+ + K K +K+A+K KP+ +E+++K+ T+ E V Sbjct: 8973 EEKKPPPKRIEVTK--KAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDV 9030 Query: 565 ASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAK 624 +SK + RK + + ++A+ ++ + S E E E + Sbjct: 9031 SSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFE 9090 Query: 625 KGLLEHGRNWSAIARMVGSKTVSQCKNFYFN-----YKKRQNLDE--------ILQQHKL 671 + E ++ K V + F Y++ + DE ++ + Sbjct: 9091 QPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVI 9150 Query: 672 KMEKERNARRKKKKAPAAASEEAAFPPV-----------------VEDEEMEASGV---- 710 +++KE ++K PA E+ A PP +E+E+++ + V Sbjct: 9151 QVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVS 9210 Query: 711 ----------SGNEEEMVEEAEATVNNS----SDTESIPSPHTE---------------- 740 + +EE++E V+ S+ + + HTE Sbjct: 9211 KKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVT 9270 Query: 741 ------AAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI--PAPTEP-TPASEATGAPTP 791 A + PK P P P P P+ + PAP P P P Sbjct: 9271 EEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKP 9330 Query: 792 PPAPPSPSAPPPVVPK-------EEKEEETAA----APPVEEGEEQKPPAAEE-LAVDTG 839 P P A PP VP+ EEK A APP + E QK EE + + T Sbjct: 9331 VPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQ 9390 Query: 840 KAEEP-------VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSS 892 + E P K + EE + P K ++ K +E + AK + Sbjct: 9391 REESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKA 9450 Query: 893 GAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 952 P+ S T V+E + +L P + T R S ++ + ++ Sbjct: 9451 PPPRAEVSKKTV----VEEKRFVAEEKLSFAVPQRVEVT---RHEVSAEEEWSYSEEEEG 9503 Query: 953 AAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPP 1012 + I V + E E+ A P + + E + + PA Sbjct: 9504 VS----ISVYREEEREEEEEAEVTEYEVMEEPEEYVVEE-----KLHIISKRVEAEPAEV 9554 Query: 1013 ADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPG 1072 +++ +K V P A K+ PP P + P + + AP P PP Sbjct: 9555 TERQEKKIVLKPKIPA---KIEEPPPAKVPEAPKKIVPEKKVP----APVPKKEKVPPPK 9607 Query: 1073 HPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHA 1132 P + +PV P PP +I +E + A + H+ ++ Sbjct: 9608 VP-----EEPKKPV----PEKKVPPKVIK-------MEEPLPA----KVTERHMQITQEE 9647 Query: 1133 KAPVGPVTMGLP----LPMDPKKLAPFSGVKQEQLSPRGQAGPP 1172 K V P +P +PK+ P K +L P+ + PP Sbjct: 9648 KVLVAVTKKEAPPKARVPEEPKRAVPEE--KVLKLKPKREEEPP 9689 Score = 40.4 bits (93), Expect = 0.022 Identities = 66/268 (24%), Positives = 91/268 (33%), Gaps = 47/268 (17%) Query: 1919 VYPTLMEPVLLPKEA--------PRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGS 1970 V PT + VL PKE P +PE P A P + P P K Sbjct: 10490 VPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKK--VPVPPPKKPE 10547 Query: 1971 EPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELR 2030 P VP V A + + + P SP P P A +K + P E+ Sbjct: 10548 VPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPV 10607 Query: 2031 SLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGE 2090 + PE PV P P + P + E+ PK P K E Sbjct: 10608 KVPEAPKEVVPEKKVPVPPPKKPEVP-----PTKVPEV----------PKVAVPEKKVPE 10652 Query: 2091 AAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPL 2150 A + P PES P P V V L + +EV+ ++ P Q++ P Sbjct: 10653 A-----IPPKPESPP---------PEVFEEPEEVALEEPPAEVV-EEPEPAAPPQVTVPP 10697 Query: 2151 PAPLYSFPGASCPVLDLRRPPSDLYLPP 2178 P+ P P + ++P LPP Sbjct: 10698 KKPV---PEKKAPAVVAKKPE----LPP 10718 Score = 38.5 bits (88), Expect = 0.082 Identities = 43/166 (25%), Positives = 61/166 (36%), Gaps = 25/166 (15%) Query: 667 QQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVN 726 ++ + K+E ++ + KK P PP EE+E V+ E ++ E + V Sbjct: 10958 EEEEPKVEPKKLEKVKKPAVPEP-------PPPKPVEEVEVPTVTKRERKIPEPTK--VP 11008 Query: 727 NSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEAT 786 +P+P + PKP A + PPP P P I AP + Sbjct: 11009 EIKPAIPLPAPEPK---------PKPEAEVKTIKPPP--VEPEPTPIAAPVTVPVVGKKA 11057 Query: 787 GAPTPPPAPPSPSAPPPVVPKEEK---EEETAAAPPVEEGEEQKPP 829 A P P P VPK+ E E P GE KPP Sbjct: 11058 EAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGE--KPP 11101 Score = 35.4 bits (80), Expect = 0.70 Identities = 152/754 (20%), Positives = 240/754 (31%), Gaps = 172/754 (22%) Query: 761 PPPGPPTPPPEDIPA---------------PTEPTPASEATGAPTPPPAPPSPSAPPPVV 805 P P PPP+ I P E TP E P PPP P+ P ++ Sbjct: 8970 PTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKP-PPPTTLIPAKAPEII 9028 Query: 806 PKEEKEEETAAAPPVEEGEEQKPPAA-----------------------EELAVD--TGK 840 K EE + E QK A +EL V+ T Sbjct: 9029 DVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEP 9088 Query: 841 AEEPVKSECTEEAEEGPAKGK---DAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQD 897 E+P E E+ EE + K E E EG E++EG G + Sbjct: 9089 FEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEG--------YDEGEEEW 9140 Query: 898 SDSSATCSADEVDEA--EGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAA 955 ++ +V + E + ++ + P P P + ++ + R Sbjct: 9141 EEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAP---PPPKVIKKPVIEKIEKTSRRME 9197 Query: 956 IPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADK 1015 +QVTKV E ++ P P+ P Q E P + Sbjct: 9198 EEKVQVTKVPEVSKK----IVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHT 9253 Query: 1016 EAEKPVFFPAFAAE---------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAF 1066 E E V P E A +PP LP P EV AP P Sbjct: 9254 EEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEV------APVPIPK 9307 Query: 1067 SYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHV 1126 PP + P +P+ P P+ K P+ + V Sbjct: 9308 KVEPPAPKV---------PEVPKKPVPEEKKPVPVPKKEPAAPPK--------------V 9344 Query: 1127 PYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQ-----------LSPRGQAGPPESL 1175 P E K PV +P+P+ KK AP + V + Q ++ R ++ PP Sbjct: 9345 P--EVPKKPVPEEK--IPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVP 9400 Query: 1176 GVPTAQEASVLRGTAL--GSVPGGSITKGIPSTRVPSDS-AITYRGSITHGTPADVLYKG 1232 +P + + VP +P VP + A+ + P + K Sbjct: 9401 EIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKK 9460 Query: 1233 TIT---RIIGEDS-----PSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKED 1284 T+ R + E+ P R++ R H + ++ E G+S++ +E+ Sbjct: 9461 TVVEEKRFVAEEKLSFAVPQRVEVTR-------HEVSAEEEWSYSEEEEGVSISVYREEE 9513 Query: 1285 GRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRG 1344 E A Y++ME PE + ++E+ HI Sbjct: 9514 RE------EEEEAEVTEYEVME--------------------EPEEYV---VEEKLHIIS 9544 Query: 1345 SITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEG 1404 + P E QE + + K+ + PPP + EA P K+ P + Sbjct: 9545 KRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPP----AKVPEA-------PKKIVPEKKV 9593 Query: 1405 LVATVKEAGRSIHEIPREELRHTPELPLAPRPLK 1438 K+ ++P E + PE + P+ +K Sbjct: 9594 PAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIK 9627 Score = 32.7 bits (73), Expect = 4.5 Identities = 45/214 (21%), Positives = 89/214 (41%), Gaps = 31/214 (14%) Query: 60 QPQRRRPSLLSEFQ-PGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLL 118 +P+ + P L+ + + P + E+ +P +P ++E +K P + P P Sbjct: 9984 KPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEK 10043 Query: 119 R---PSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPS-----PPHTDPELELVP-----P 165 + P+P PA ++ K + + + +P P PP + E VP P Sbjct: 10044 KVPVPAPKKVEAPPAKVPEVPK-KLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALP 10102 Query: 166 R----LSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIES 221 + L +EE++ + + E ++ ++ L ++++ L EE PPE E+ PP E Sbjct: 10103 QEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEE---VPPEEE 10159 Query: 222 KHRSLVQIIYDENRKKAEAAHRILEGLGPQVELP 255 Y ++ +L + P+V +P Sbjct: 10160 ---------YVPEEEEFVPEEEVLPEVKPKVPVP 10184 >gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 899 Score = 87.8 bits (216), Expect = 1e-16 Identities = 103/543 (18%), Positives = 229/543 (42%), Gaps = 45/543 (8%) Query: 166 RLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRS 225 R +E++ + +R+ + + +Q K+ +++++L E+ + E EK + + Sbjct: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEE 348 Query: 226 LVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMR----KKLI 281 +Q ++ ++ E E + Q E L+ Q R+ + ++ + ++L Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEER-LWEQEKQMREQEQKMRDQEERMWEQDERLR 407 Query: 282 LYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIR 341 +R K WEQ R ++ M+ EKK E + +E ++RE +K E Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEE---KMQEEERIREREKKMREEEE 464 Query: 342 KQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYD 401 RE +E+MQ + + + + E + L EQE +++Q ++ Sbjct: 465 TMREQEEKMQKQ--EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW-------- 514 Query: 402 ADQQRIKFINMNGLMADPMKVYKDRQVMN----MWSEQEKETFREKFMQHPKNFGLIASF 457 +Q K + + K+++ ++ MW ++EK +E+ M + Sbjct: 515 --EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER------ 566 Query: 458 LERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQ---QQQQQQQQQQQQQQQQPMPR 514 +E+KT + + +K + + R + R + + +Q+++ Q+Q+++ Q+Q Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626 Query: 515 SSQEEKDEKEKEKEAEKEE----------EKPEVENDKEDLLK-EKTDDTSGEDNDEKEA 563 QEEK ++++EK E+EE E+ + KE L + EK + E++ Sbjct: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686 Query: 564 VASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETA 623 + + + +K M E + E + E E E + EE+M+ Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746 Query: 624 KKGLLE-HGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRK 682 ++ + E + W +M + + + K + ++K Q ++I +Q + ++E R + Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806 Query: 683 KKK 685 ++K Sbjct: 807 EEK 809 Score = 87.4 bits (215), Expect = 2e-16 Identities = 113/591 (19%), Positives = 245/591 (41%), Gaps = 79/591 (13%) Query: 170 EELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQI 229 EEL + D + E+ +LKKK +L+E+ P+ +S +Q+ Sbjct: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKL-------------PLAESEKSEIQL 246 Query: 230 IYDENRKKAEAAHRILEGLGPQVEL-----PLYNQPSDTRQYHENIKINQAMRKKLILYF 284 E ++K E A +L PQV+ ++ Q + R+ + I Sbjct: 247 NVKELKRKLERAKFLL----PQVQTNTLQEEMWRQEEELREQEKKI-------------- 288 Query: 285 KRRNHARKQWEQKFCQRYDQ-LMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQ 343 R K W Q+ R + M E+K+ R E R + KE + +E ++ E+R+Q Sbjct: 289 --RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQ 346 Query: 344 RELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDAD 403 E + + ++ ++ + + + + + + E++MR +++ D Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ---EERMWEQD 403 Query: 404 QQ-RIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKT 462 ++ R K M +V K R+ M +++K +E+ MQ + + + Sbjct: 404 ERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE 463 Query: 463 VAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDE 522 + K+ EN + ++++ +Q+++ +Q++ Q+Q++ + ++ +D+ Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523 Query: 523 KE----------KEKEAEKEEEKPEVEN----------DKEDLLKEKTDDTSGEDNDEKE 562 +E +EK E+E++ E E D+E+ +++KT + + D++E Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583 Query: 563 AVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEE--M 620 + + R + +K R M E EE + Q+ M+ E W +EE Sbjct: 584 KMREEERM---REREKKMREEEEMMRE--QEEKMQEQEE----KMQEQEEKMWEQEEKMQ 634 Query: 621 ETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNAR 680 E +K + + W +M + + + K + ++K Q +++ +Q + E+E+ + Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694 Query: 681 RKKKKAPAAASEEAAFPPVVEDEEM-EASGVSGNEEEMVEEAEATVNNSSD 730 + +++ +E + E+E M E EEEM+ E E + + Sbjct: 695 KTQEQEKKTWDQE----KMREEESMREREKKMREEEEMMREQEEKMQEQEE 741 Score = 72.4 bits (176), Expect = 5e-12 Identities = 94/480 (19%), Positives = 198/480 (41%), Gaps = 46/480 (9%) Query: 169 KEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQ 228 +E++ + ++++ E M EQ+ ++++ EEE + E + + + + + Sbjct: 416 QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475 Query: 229 IIYDENRKKAEAAHRILEGLGPQVEL-----PLYNQPSDTRQYHENIKINQAM---RKKL 280 +EN + E + L Q E + Q + E I+ + M KK+ Sbjct: 476 --QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533 Query: 281 ILYFKRRNHARKQWEQKFCQRYDQLMEAW-------------EKKV----ERIENNPRRR 323 K R + WEQ+ R DQ + W EKK E++ R R Sbjct: 534 WRQEKMREQEDQMWEQEEKMR-DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMR 592 Query: 324 AKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQE 383 +E K+RE E + K +E +E+MQ + + E ++ E + + EQE Sbjct: 593 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQE 651 Query: 384 NLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREK 443 + ++L L++ ++ + + K+++ ++ EQEK+T+ ++ Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQ----EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE 707 Query: 444 FMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQ 503 M+ ++ E+K E + +K + + ++ + +++ +Q+++ Sbjct: 708 KMREEESM----REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEK 763 Query: 504 QQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGED---NDE 560 +QQ+ P +E+ E EK +E EK E+ E D+E+ ++ + + G++ + Sbjct: 764 MWEQQRLP---EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820 Query: 561 KEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEM 620 +E + + K + + G+ + E EE + Q E E E R EE+M Sbjct: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKM---QGQEEKMREQEEKMRGQEEKM 877 Score = 55.5 bits (132), Expect = 7e-07 Identities = 84/448 (18%), Positives = 188/448 (41%), Gaps = 64/448 (14%) Query: 166 RLSKEELIQNMDRVDREI--TMVEQQISKLKKKQQQLEEEAAK-------PPEPEKPVSP 216 ++ +EE I+ ++ RE TM EQ+ K++K+++ + E+ K P + EK Sbjct: 445 KMQEEERIREREKKMREEEETMREQE-EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503 Query: 217 PPIESKHRSL---VQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKIN 273 ++ + + + I D+ + + + E ++ Q R + + Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563 Query: 274 QAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAK-----ESK 328 + +K K + +K W+Q+ R ++ M EKK+ E R + + E K Sbjct: 564 EERMEK-----KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK 618 Query: 329 VREYYEKQFPEIRKQRELQERM----------------QSRVGQRGSGLSMSAARSEHE- 371 ++E EK + + K +E +E+M Q R+ ++ L E E Sbjct: 619 MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678 Query: 372 VSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMN- 430 + E + + EQE +EK+ ++ +D ++ R + + K+ ++ ++M Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQE---KKTWDQEKMREE----ESMREREKKMREEEEMMRE 731 Query: 431 ----MWSEQEK--ETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVR 484 M ++EK E E + Q K + E++ + E + +K + + + Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791 Query: 485 RSYRRRGKSQQQQQQQQQQQQQQQQ----------QPMPRSSQEEKDEKEKEKEAEKEEE 534 + + R + ++ + Q+++ + Q+++ Q QEEK ++EK +EE+ Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851 Query: 535 KPEVENDKEDLLKEKTDDTSGEDNDEKE 562 E +E+ ++E+ + G++ +E Sbjct: 852 MEEKMQGQEEKMREQEEKMRGQEEKMRE 879 Score = 55.1 bits (131), Expect = 9e-07 Identities = 69/368 (18%), Positives = 162/368 (44%), Gaps = 60/368 (16%) Query: 169 KEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQ 228 +EE ++ +R+ + ++ +++++++++E+ K E E+ + E K + + Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ--EEKMQEQEE 638 Query: 229 IIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRN 288 ++++ K E ++ E Q LP + + HE ++ + M+++ Sbjct: 639 KMWEQEEKMWEQEEKMWE----QQRLP---EQKEKLWEHEKMQEQEKMQEQ--------- 682 Query: 289 HARKQWEQKFCQRYDQLME--AWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQREL 346 K WEQ+ ++ Q E W+++ R E + R R E K+RE E + K +E Sbjct: 683 -EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQ 739 Query: 347 QERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQR 406 +E+MQ + E E+ E + + EQE + ++L L++ ++ Sbjct: 740 EEKMQEQ---------------EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK-- 782 Query: 407 IKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAEC 466 M + K+++ + M ++EK +E+ M+ + E+ E Sbjct: 783 ---------MQEQEKIWEQEEKMR--DQEEKMRGQEEKMRGQE---------EKMRGQEE 822 Query: 467 VLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKE 526 ++ K + + + + G+ ++ +++ Q Q+++ ++Q QEEK +++E Sbjct: 823 KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882 Query: 527 KEAEKEEE 534 K +EE+ Sbjct: 883 KMRGQEEK 890 >gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens] Length = 816 Score = 87.0 bits (214), Expect = 2e-16 Identities = 124/491 (25%), Positives = 163/491 (33%), Gaps = 94/491 (19%) Query: 762 PPGPPTPPPEDIPAPTEPTPASEAT-------------GAPTPPPAP---PSPSAPPPVV 805 PPG P PPP PA A+ A GA P AP P+ ++ PP Sbjct: 29 PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPAS 88 Query: 806 PKEEK---EEETAAAP------------PVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 850 + E+ + T+ P P G++ +AEE V GKA E K Sbjct: 89 GRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE-TVARGKATEAPKRSAL 147 Query: 851 EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 910 G +A E G R + P + + SA E Sbjct: 148 SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 207 Query: 911 EAE-----------GGDKNR------------LLSPRPSLLTPTGDPRANASPQKPLDLK 947 E GG R L SP S + G PRA A P +P Sbjct: 208 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP---- 263 Query: 948 QLKQRAAAIPPIQVTKVHEPPREDAAP----------TKPAPPAPPPPQNLQPESDAPQQ 997 + A+ P QVT PPR+DAAP P+P APP P P Sbjct: 264 -KPKGLQALRPPQVT----PPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP 318 Query: 998 PGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS 1057 P + P + S P + + P + A P PP +PP + + Sbjct: 319 PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA------LALPPLQAPPSP 372 Query: 1058 PHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRP-PTISNP------PPLISSAKHPSVLE 1110 P +P S + P P L +H P P P P + P PP+ SA PS Sbjct: 373 PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 432 Query: 1111 RQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAG 1170 + A L VP S A P+ P P P P K +P A Sbjct: 433 PSLAA------PPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 486 Query: 1171 PP-ESLGVPTA 1180 PP ++L P A Sbjct: 487 PPLQALPSPPA 497 Score = 70.1 bits (170), Expect = 3e-11 Identities = 118/536 (22%), Positives = 150/536 (27%), Gaps = 92/536 (17%) Query: 683 KKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAA 742 K +P S + G+ + EE V +AT S + + Sbjct: 98 KNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSG 157 Query: 743 KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPP 802 G P A G G P P P P P P + A PSP+A Sbjct: 158 PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA-- 215 Query: 803 PVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD 862 ++P A G + P + A Sbjct: 216 ----------------------RRRPSAG-------GGLQRPASRSLSSSAT-------- 238 Query: 863 AEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLS 922 L + + G S R T + Q D L Sbjct: 239 ----------PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG 288 Query: 923 PRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEP---------PREDAA 973 P S T P A SP P L+ L A P T + P P + Sbjct: 289 PLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLS 348 Query: 974 PTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKL 1033 P PP PP L P P P S P +P+P A A A + Sbjct: 349 PLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPN---------ALAVHLLQA 399 Query: 1034 PGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTI 1093 P PP P PP + SP A P + S PP P A P L PP+ Sbjct: 400 PFSPP--------PSPPVQA-PFSPPASPPVSPSATPPSQAPP----SLAAPPLQVPPSP 446 Query: 1094 SNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLA 1153 PP+ SA P + A +QL P + A P LP P Sbjct: 447 PASPPMSPSATPPPQAPPPLAA----PPLQLAKPPPQAPPALATPPLQALPSP------- 495 Query: 1154 PFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVP 1209 P S Q SP P L P Q VL L P + + + R P Sbjct: 496 PASFPGQAPFSPSASL-PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP 550 Score = 66.2 bits (160), Expect = 4e-10 Identities = 94/388 (24%), Positives = 137/388 (35%), Gaps = 57/388 (14%) Query: 734 IPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAP--TEPTPASEATGAPT- 790 + P +AA G P AT PP P + +P+P T P+ A+ + G+PT Sbjct: 276 VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL 335 Query: 791 ---------PPPAP---PSPSAPPPV-VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVD 837 PP +P P P APP + +P + A+PP+ P A LAV Sbjct: 336 QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395 Query: 838 TGKA------EEPVKSECTEEAEE--GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTA 889 +A PV++ + A P+ ++A + A L+ S A+ Sbjct: 396 LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP----SPPASPP 451 Query: 890 KSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP-----RANASPQKPL 944 S A + +A + A+ + P L P +A SP L Sbjct: 452 MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 511 Query: 945 DLKQLKQRAAAIPPIQVTKVHE-PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1003 + L PP+ + + PP A+PT AP PP P P S PR Sbjct: 512 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP--------GPDTSVSGPR 563 Query: 1004 ---GKSRSPAPPADKEAEKPVFFPAFA---AEAQKLPGDPPCWTSG-----LPFPVPPRE 1052 + P PP + + P A + A P + + SG P P E Sbjct: 564 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAE 623 Query: 1053 VIKASPHA----PDPSAFSYAPPGHPLP 1076 + P A P P PG PLP Sbjct: 624 LAACHPAAWSRGPAPPLAFRGAPGAPLP 651 Score = 63.2 bits (152), Expect = 3e-09 Identities = 136/566 (24%), Positives = 188/566 (33%), Gaps = 135/566 (23%) Query: 1737 PTPGTPATAMDRLAYLPTA----PQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRD 1792 PTPGTP+ AM R + P+P S P PT + + +S+SE Sbjct: 158 PTPGTPSPAMARRSRAAGTEVGLPRPAPSAR------PRPPTEGPRKSVSSASEHSTTEP 211 Query: 1793 RERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSG--SSGGGGGSSSRPASHSHAHQ 1850 R R L RP + S S+ SS G S+R + AH Sbjct: 212 SPAARRRPSAGGGLQ-----------RPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 260 Query: 1851 HSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT------- 1903 P P+ AL+ P V K A+ P + + L + S S+P P+A Sbjct: 261 SQP-KPKGLQALRP-PQV--TPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLP 316 Query: 1904 FPPATH-----CPLGG-TLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLA--KPP 1955 PPAT LG TL + L P L P P P+ P A A PP Sbjct: 317 SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP---PQAPPALALPPLQAPPSPP 373 Query: 1956 ARSGLEPASSPSKGSE--------------------PRPLVPPVSGHATIARTPAKNLAP 1995 A L P ++PS + P PP S + + TP P Sbjct: 374 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433 Query: 1996 HHASPDPPAPPASASDPHREKTQSKPFS---------------------------IQELE 2028 A+P PP+ + P + + P +Q L Sbjct: 434 SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493 Query: 2029 LRSLGYHGSS-YSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKS-----HLEGELRPKQP 2082 + G + +SP P+SP+++P L L ++ S L+ RP P Sbjct: 494 SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP 553 Query: 2083 GP-VKLGGEAAHLPHLRPLPESQPSSSP-LLQTAPGVKGHQRVVTLAQH----------- 2129 GP + G L L P P PS SP + P + GH T Sbjct: 554 GPDTSVSGPRLTLA-LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 612 Query: 2130 ---ISEVITQDYTRHHPQQLS--------------APLPAPLYSFPGAS---CPVLDLRR 2169 S + HP S APLP P + PG++ C + + Sbjct: 613 GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 672 Query: 2170 PPSDLYLPPPDHGAPARGSPHSEGGK 2195 P S P P SP + GGK Sbjct: 673 PESATPAPGALDPGP---SPGTSGGK 695 Score = 41.6 bits (96), Expect = 0.010 Identities = 50/188 (26%), Positives = 62/188 (32%), Gaps = 28/188 (14%) Query: 728 SSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATG 787 +S T P DT +GP+ L A GPPP P P + P +S AT Sbjct: 540 ASPTLQAPRRPPTPGPDTSVSGPRLTLAL-APGPPPPPSRSPSSTLSGPDLAGHSSSATS 598 Query: 788 AP------TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA 841 P P + ++PPP + E AA P PP A A Sbjct: 599 TPEELRGYDSGPEGGAAASPPP-------DAELAACHPAAWSRGPAPPLAFRGAPGAPLP 651 Query: 842 EEPVKSE------CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS-GRATTAKSSGA 894 P CT EGP + A GAL G S G+A +GA Sbjct: 652 WPPATGPGSADGLCTIYETEGP-------ESATPAPGALDPGPSPGTSGGKAAAGAGAGA 704 Query: 895 PQDSDSSA 902 S A Sbjct: 705 SSRSPKQA 712 Score = 36.2 bits (82), Expect = 0.41 Identities = 79/310 (25%), Positives = 110/310 (35%), Gaps = 56/310 (18%) Query: 2158 PGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVS 2217 P A P L RPP PPP A R + R P + +GG + Sbjct: 17 PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG-------AT 69 Query: 2218 PPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSP-------GNTSQPPAFFSK--LTE 2268 PE G +R++ P R GE+ P++ S P T++P K Sbjct: 70 IPESAPRAGPTRTSRPPASGR-GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128 Query: 2269 SNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHAS 2328 + + + K E K+ + + PGT PA M RS+A A Sbjct: 129 AEETVARGKATEAPKRSALSAGARRDTSGPTPGTP---SPA------MARRSRA----AG 175 Query: 2329 TNMGLEAIIRKAL----MGGGGKAKVSGRPSSRKAKSPA----PGLASGDRPPSVSSVHS 2380 T +GL A G K+ S S SPA P G + P+ S+ S Sbjct: 176 TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS 235 Query: 2381 EGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPP----------PGL- 2429 TPL++ PS+ G+ P +P + G+ A PP P L Sbjct: 236 SA-----TPLSSPA-RSGPSARGTPRAPAHPSQPK-PKGLQALRPPQVTPPRKDAAPALG 288 Query: 2430 PAGSGPLAGP 2439 P S PLA P Sbjct: 289 PLSSSPLATP 298 >gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] Length = 416 Score = 86.7 bits (213), Expect = 3e-16 Identities = 93/385 (24%), Positives = 134/385 (34%), Gaps = 35/385 (9%) Query: 727 NSSDTESIPSPHTEAAKDTGQNGPK-PPATLGA-DGPPPGPPTPPPEDIPAPTEPT-PAS 783 + ++ S+ + + + A G N P+ PP+ G GPPP P P P +P P Sbjct: 24 SQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 83 Query: 784 EATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQ----KPPAAEELAVD 837 + P PP P P PPP K P P +G Q PP + Sbjct: 84 QGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 143 Query: 838 TGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQD 897 +P + + P +G + + + G + +GG+ G PQ Sbjct: 144 PQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 203 Query: 898 SDSSATCSADEVDEAEGGDKNRLLSP--RPSLLTPTGDPR---ANASPQKPLDLKQLKQR 952 +GG+K + P +P P GD + A + P KP Sbjct: 204 ------------PPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGN 251 Query: 953 AAAIPPIQVTKVHEPPREDAAPTKP-APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP 1011 PP K PP + KP PP P PQ P+ + + SP GK + P P Sbjct: 252 QPQGPPPPPGKPQGPPPQGG--NKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPP 309 Query: 1012 PADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPP 1071 + + P P K G PP + P PP + P S + +PP Sbjct: 310 QGGNQPQGPPPPPG------KPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPP 363 Query: 1072 GHPLPLGLHDTARPVLPRPPTISNP 1096 G P + P P PP NP Sbjct: 364 GKPQGPPQQEGNNPQGPPPPAGGNP 388 Score = 65.5 bits (158), Expect = 6e-10 Identities = 78/298 (26%), Positives = 105/298 (35%), Gaps = 57/298 (19%) Query: 749 GPKPPATLGADGPPPG--PPTPPPE-DIPAPTEPTPASEATGAPT--------PPPAPPS 797 GP P GPPP P PPP+ D + + +P + G P PPP P Sbjct: 141 GPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGK 200 Query: 798 PSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPA-----AEELAVDTGKAEEPVKSECTEE 852 P PPP + + PP G+ Q PP ++ GK + P Sbjct: 201 PQGPPP-----QGGNKPQGPPP--PGKPQGPPPQGDNKSQSARSPPGKPQGP-------- 245 Query: 853 AEEGPAKGKDAEAAEATAEGALKAEKKEGGS---GRATTAKSSGAPQDSDSSATCSADEV 909 P +G + G + +GG+ G K G P S + S Sbjct: 246 ----PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPP 301 Query: 910 DEAEGGDK---NRLLSPRPSLLTPTGDPRANAS----------PQKPLDLKQLKQRAAAI 956 + +G N+ P P P G P + PQ P K R+A Sbjct: 302 GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARS 361 Query: 957 PPIQVTKVHEPPREDAA-PTKPAPPAPPPPQNLQ-PESDAPQQPGSSPRGKSRSPAPP 1012 PP K PP+++ P P PPA PQ Q P + PQ P P+G R PP Sbjct: 362 PP---GKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQG-GRPSRPP 415 Score = 63.5 bits (153), Expect = 2e-09 Identities = 71/309 (22%), Positives = 105/309 (33%), Gaps = 45/309 (14%) Query: 744 DTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT-PASEATGAPTPPPAPPSPSAPP 802 D ++ PP GPPP P P P +P P + P PP P P PP Sbjct: 106 DKSRSPRSPPGK--PQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP 163 Query: 803 PVVPKEEKEEETAAA----PPVEEGEEQK---PPAAEELAVDTGKAEEPVKSECTEEAEE 855 P + + + PP + G + + PP + +P + + Sbjct: 164 PQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 223 Query: 856 GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGG 915 P +G + + + G + +GG+ G PQ +GG Sbjct: 224 PPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP------------QGG 271 Query: 916 DKNRLLSP--RPSLLTPTGDPRANAS---PQKPLDLKQLKQRAAAIPPIQVTKVHEPPRE 970 +K + P +P P G ++ +S P KP PP K PP + Sbjct: 272 NKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 331 Query: 971 DA----APTKPAPPAPPPPQNLQPESDA----------PQQPGSSPRGKSRSPAPPADKE 1016 P P P PPPQ A PQQ G++P+G P PPA Sbjct: 332 GGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQG----PPPPAGGN 387 Query: 1017 AEKPVFFPA 1025 ++P PA Sbjct: 388 PQQPQAPPA 396 Score = 55.1 bits (131), Expect = 9e-07 Identities = 67/249 (26%), Positives = 80/249 (32%), Gaps = 32/249 (12%) Query: 957 PPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKE 1016 PP K PP P P P PQ P PQ P K + P PP + Sbjct: 40 PPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 99 Query: 1017 AEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLP 1076 P + + P PP G P PP+ P P P PPG P Sbjct: 100 GPPP------QGDKSRSPRSPP----GKPQGPPPQG--GNQPQGPPP------PPGKPQG 141 Query: 1077 LGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPV 1136 +P P PP PP K S R QG P + P Sbjct: 142 PPPQGGNKPQGPPPPGKPQGPPPQGDNKSRS--SRSPPGKPQG-------PPPQGGNQPQ 192 Query: 1137 GPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVP- 1195 GP P P P+ P G K + P G+ P G +Q A G G P Sbjct: 193 GPP----PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQ 248 Query: 1196 GGSITKGIP 1204 GG+ +G P Sbjct: 249 GGNQPQGPP 257 Score = 52.0 bits (123), Expect = 7e-06 Identities = 66/274 (24%), Positives = 98/274 (35%), Gaps = 31/274 (11%) Query: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT-PASEATGAPTPPP 793 P P + + ++ P P GPPP P P P +P P + P PP Sbjct: 162 PPPQGDNKSRSSRSPPGKP-----QGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 216 Query: 794 APPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAA-----EELAVDTGKAEEPVKSE 848 P P PPP + + + ++A +PP G+ Q PP + GK + P + Sbjct: 217 PPGKPQGPPP---QGDNKSQSARSPP---GKPQGPPPQGGNQPQGPPPPPGKPQGP-PPQ 269 Query: 849 CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908 + + P GK +G K+ G+ G Q + Sbjct: 270 GGNKPQGPPPPGKPQGPPP---QGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 326 Query: 909 VDEAEGGDKNRLLSP--RPSLLTPTGDPR---ANASPQKPLDLKQLKQRAAAIPPIQVTK 963 +GG+K + P +P P G + A + P KP Q + PP Sbjct: 327 GPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP---PP 383 Query: 964 VHEPPREDAAPTKPAPPAPP-PPQNLQPESDAPQ 996 P++ AP P PP PPQ +P S PQ Sbjct: 384 AGGNPQQPQAPPAGQPQGPPRPPQGGRP-SRPPQ 416 Score = 36.6 bits (83), Expect = 0.31 Identities = 69/316 (21%), Positives = 82/316 (25%), Gaps = 83/316 (26%) Query: 1954 PPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLA--PHHASPDPPAPPASASD 2011 PP + G +P P G P PP + R+P P P PP Sbjct: 81 PPPQGGNKPQGPPPPGKPQGP--PPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGK 138 Query: 2012 PHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKS 2071 P Q P+G P P D +KS Sbjct: 139 PQGPPPQG------------------GNKPQGPPPPGKPQGPPPQGD----------NKS 170 Query: 2072 HLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHIS 2131 K GP GG P P P +P P Sbjct: 171 RSSRSPPGKPQGPPPQGGNQPQGP---PPPPGKPQGPP---------------------- 205 Query: 2132 EVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD-----LRRPPSDLYLPPPDHGAPAR 2186 PQ + P P P P D R PP PPP G + Sbjct: 206 -----------PQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQ 254 Query: 2187 GSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG--HSRSAVYPLLYRDGEQTE 2244 G P G + P P G G P P+G G SRS+ P G+ Sbjct: 255 GPPPPPGKPQGPPPQG----GNKPQGPPPPGKPQGPPPQGGSKSRSSRSP----PGKPQG 306 Query: 2245 PSRMGSKSPGNTSQPP 2260 P G P PP Sbjct: 307 PPPQGGNQPQGPPPPP 322 Score = 33.1 bits (74), Expect = 3.5 Identities = 27/92 (29%), Positives = 31/92 (33%), Gaps = 9/92 (9%) Query: 2170 PPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG-HS 2228 PP PPP G +G P G + P P G G P P+G G S Sbjct: 53 PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG----GNKPQGPPPPGKPQGPPPQGDKS 108 Query: 2229 RSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPP 2260 RS P G+ P G P PP Sbjct: 109 RSPRSP----PGKPQGPPPQGGNQPQGPPPPP 136 >gi|149773456 hypothetical protein LOC643314 [Homo sapiens] Length = 1427 Score = 85.1 bits (209), Expect = 8e-16 Identities = 101/375 (26%), Positives = 136/375 (36%), Gaps = 40/375 (10%) Query: 728 SSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATG 787 +S ++P+P + P+ P + A PPP PT P +P P EPT + A Sbjct: 1001 ASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVP 1060 Query: 788 APTPP-------PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840 P P P P P++P VP E+ AAA P EE PAA AV T Sbjct: 1061 TPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTP--EEPTSPAA---AVPT-- 1113 Query: 841 AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 900 EEP E PA A A E A A A+ A + P++S S Sbjct: 1114 PEEPASPAAAVPTPEEPA--SPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESAS 1171 Query: 901 SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQ 960 A + A L S P A + L++ AA++P + Sbjct: 1172 PAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVA-----TLEEFTSPAASVPTSE 1226 Query: 961 VTKVHEPPREDAA---PTKPAPPAPPPPQNLQPESDA----PQQPGSSPRGKSRSPAPPA 1013 EP AA P +P PA P +P S A + SSP +P PA Sbjct: 1227 -----EPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPA 1281 Query: 1014 DKEAE-KPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPG 1072 A + PA A A P + +P P + A P A P +P G Sbjct: 1282 SPAAAVSNLEEPASPAAAVPTPE-----VAAIPAASVPTPEVPAIPAAAVPPMEEVSPIG 1336 Query: 1073 HP-LPLGLHDTARPV 1086 P L + H + P+ Sbjct: 1337 VPFLGVSAHTDSVPI 1351 Score = 74.3 bits (181), Expect = 1e-12 Identities = 90/356 (25%), Positives = 129/356 (36%), Gaps = 46/356 (12%) Query: 675 KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNN--SSDTE 732 +E + + P + AA P E+ A+ V EE A +S Sbjct: 985 EEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAA 1044 Query: 733 SIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP 792 ++P+P + P+ P + A P P PT P +P P EPT S A PTP Sbjct: 1045 AVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPT--SPAAAVPTPE 1102 Query: 793 ---------PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAA---EELAVDTGK 840 P P P++P VP E+ AAA P E PA EE A Sbjct: 1103 EPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVA 1162 Query: 841 AEEPVKSECTEEAEEGPAKGKDAEAAEATAE------------GALKAEKKEGGSGRATT 888 P +S A PA+ A AT E A+ A +E S A+ Sbjct: 1163 VPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASV 1222 Query: 889 AKS-------SGAPQDSDSSATCSADEVDEAEGGDKNRLLSPR----PSLLTPTGDPRAN 937 S + + ++ +A E +L+P P+ PT P Sbjct: 1223 PTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPT--PEEP 1280 Query: 938 ASPQKPL-DLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAP--PPPQNLQP 990 ASP + +L++ AAA+P +V + P P PA PA PP + + P Sbjct: 1281 ASPAAAVSNLEEPASPAAAVPTPEVAAI--PAASVPTPEVPAIPAAAVPPMEEVSP 1334 Score = 73.9 bits (180), Expect = 2e-12 Identities = 91/384 (23%), Positives = 133/384 (34%), Gaps = 37/384 (9%) Query: 731 TESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPT 790 TE +P T + P+ P T P P P +P P EPT S A PT Sbjct: 965 TEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPT--SPAAAVPT 1022 Query: 791 P-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSEC 849 P P P+ + PPP EE T+ A V EE PAA AV T EEP Sbjct: 1023 PEEPTSPAAAVPPP-------EEPTSPAAAVPTPEEPTSPAA---AVPT--PEEPTSPAA 1070 Query: 850 TEEAEEGPAKGKDA--EAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSAD 907 E P A E T+ A +E T+ ++ P + ++ +A Sbjct: 1071 AVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEE------PTSPAAAVPTPEEPASPAAAV 1124 Query: 908 EVDEAEGGDKNRLLSPR----PSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTK 963 E + +P P+ PT + A+A+ P + AA P + Sbjct: 1125 PTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESAS 1184 Query: 964 VHEPPREDAAPTKPAPPAPPP-------PQNLQPESDAP--QQPGSSPRGKSRSPAPPAD 1014 PT PA P P + P + P ++P S S P + Sbjct: 1185 FAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSP 1244 Query: 1015 KEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYA-PPGH 1073 A + P +A A P + + +P P P A + +P++ + A P Sbjct: 1245 AAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPE 1304 Query: 1074 PLPLGLHDTARPVLPRPPTISNPP 1097 + P +P P + PP Sbjct: 1305 VAAIPAASVPTPEVPAIPAAAVPP 1328 Score = 69.7 bits (169), Expect = 3e-11 Identities = 134/590 (22%), Positives = 192/590 (32%), Gaps = 117/590 (19%) Query: 711 SGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGP----- 765 +GN E ++EE + S T ++P+ + A D P+ ++ A P G Sbjct: 817 AGNTEPVLEEWIPVLQRPSRTAAVPT--VKDALDAALPSPEEGTSIAAVPAPEGTAVVAA 874 Query: 766 --PTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 823 P P + + A + T A P + A VP E TAA V Sbjct: 875 LVPFPHEDILVASIVSLEEEDVTAAAVSAPERATVPAVTVSVP-----EGTAAVAAVSSP 929 Query: 824 EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 883 EE P A + + A E A P +D T EG + Sbjct: 930 EETAPAVAAAITQEGMSAVAGFSPEWAALAITVPITEEDG-----TPEGPV--------- 975 Query: 884 GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 943 T A + AP++ D++A V E P P PT A +P++P Sbjct: 976 ---TPATTVHAPEEPDTAAV----RVSTPEEPASPAAAVPTPE--EPTSPAAAVPTPEEP 1026 Query: 944 LDLKQLKQRAAAIPPIQ--------VTKVHEPPREDAA------PTKPAPPAPPPPQNLQ 989 AAA+PP + V EP AA PT PA P P + Sbjct: 1027 TS------PAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTS 1080 Query: 990 PES--DAPQQPGSSPRGKSRSPAPPADKEAEKPV-FFPAFAAEAQKLPGDPPCWTSGLP- 1045 P + P++P +SP +P P A P PA A A P +P + +P Sbjct: 1081 PAAAVPTPEEP-TSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPT 1139 Query: 1046 -----FPVP----PREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVL----PRPPT 1092 FP P P E A+ P P + P P A V P P Sbjct: 1140 PEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPA 1199 Query: 1093 ISNPPPL---------------ISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVG 1137 S P P + +++ P+ L + + S VP E + Sbjct: 1200 ASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAA 1259 Query: 1138 PV---------TMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRG 1188 V +P P +P A +E SP PE +P A Sbjct: 1260 AVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAA-------- 1311 Query: 1189 TALGSVPGGSITKGIPSTRVP-----SDSAITYRGSITHGTPADVLYKGT 1233 SVP + IP+ VP S + + G H + +GT Sbjct: 1312 ----SVPTPEV-PAIPAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGT 1356 Score = 36.6 bits (83), Expect = 0.31 Identities = 77/366 (21%), Positives = 113/366 (30%), Gaps = 70/366 (19%) Query: 1882 EPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPER 1941 EP T V R ++ P PAA P T EP P P Sbjct: 986 EPDTAAV-RVSTPEEPASPAAAVP----------------TPEEPTSPAAAVPTPEEPTS 1028 Query: 1942 PRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPD 2001 P A A PP PA++ EP + A TP + +P A P Sbjct: 1029 PAA-------AVPPPEEPTSPAAAVPTPEEP-------TSPAAAVPTPEEPTSPAAAVPT 1074 Query: 2002 PPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGL 2061 P P + A+ + + P + + +PE EP SP ++ + Sbjct: 1075 PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPE--EPASPAAAVPTPEEPAS 1132 Query: 2062 PKHLEELDKSHLEGELRPKQPGP-VKLGGEAAHLPHLRPLPESQPSSSPLLQT------- 2113 P + + P P P V E+A P PE S + + T Sbjct: 1133 P-------AAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASF 1185 Query: 2114 -------------APGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLY-SFPG 2159 A V +V + + T P L+A + P + P Sbjct: 1186 AAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPA 1245 Query: 2160 ASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPP 2219 A+ P L+ + L P + +PA P E EP + + EP SP Sbjct: 1246 AAVPTLEEPTSSAAAVLTPEELSSPAASVPTPE------EPASPAAAVSNLE--EPASPA 1297 Query: 2220 EGMTEP 2225 + P Sbjct: 1298 AAVPTP 1303 >gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo sapiens] Length = 5537 Score = 83.6 bits (205), Expect = 2e-15 Identities = 133/559 (23%), Positives = 193/559 (34%), Gaps = 113/559 (20%) Query: 692 EEAAFPPVVEDEEM----EASGVSGNEEEMVEEAEATVNNSS-DTESIPSPHTEAAKDTG 746 EE+ P E+ + E+S S EE + E + + + +T P P Sbjct: 490 EESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPF 549 Query: 747 QNGP----------KPPATLGADGPPP--GPPTPPPEDIPAPTEPTPASEAT-----GAP 789 + P PP PPP P +PPPE+ +P P P + +P Sbjct: 550 EESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEE--SPMSPPPEASRLFPPFEESP 607 Query: 790 TPPPAPPSPSAPPPVVPK-EEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSE 848 PP SP +PPP + E++ +PP EE PP L+ PV S Sbjct: 608 LSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLS------PLPVVSR 661 Query: 849 CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGA---PQDS------- 898 + EE P E+ + A + S + + S A P+DS Sbjct: 662 LSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLE 721 Query: 899 --------DSSATCSADEVDEAEGGDKNRLLSPRPS---LLTPTGDPRANASPQKPL--- 944 + C E + LSPRP L +P + P++P Sbjct: 722 ESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCA 781 Query: 945 --DLKQLKQRAAA--IPPIQVTKVHEPPREDAAPTKPAPPAP-----PPPQNLQPESDAP 995 + L +A + P Q ++H P+ + P P P P +L P+S+ P Sbjct: 782 VPEEPHLSPQAEGPHLSP-QPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP 840 Query: 996 ---------------QQPGSSPRGKSRSPAPPADKEA--EKPVFFPAFAAEAQKLPGDPP 1038 ++P SPR + + P P A E P+F P L G+P Sbjct: 841 CLSPRPEESHLSPELEKPPLSPRPE-KPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPA 899 Query: 1039 CWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPP 1098 G P P +P P +P G P L P P PP +S P Sbjct: 900 LSEPGEP------------PLSPLPEELPLSPSGEP---SLSPQLMPPDPLPPPLS---P 941 Query: 1099 LISSAKHPSV-----LERQIGAISQG-MSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKL 1152 +I++A P++ LE GA L P E +P P P+ P L Sbjct: 942 IITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMIL 1001 Query: 1153 APFSGVKQEQLSPRGQAGP 1171 P G SP G A P Sbjct: 1002 PPSPG------SPVGPASP 1014 Score = 77.8 bits (190), Expect = 1e-13 Identities = 131/543 (24%), Positives = 195/543 (35%), Gaps = 91/543 (16%) Query: 704 EMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGP-KPPATLGADGPP 762 + EA + ++ + EA +N + +P P + P PP PP Sbjct: 413 QCEAKPLGKAGVQLEPQLEAPLNE--EMPLLPPPEESPLSPPPEESPTSPPPEASRLSPP 470 Query: 763 P--------------------GPPTPPPEDIPA--PTEPTPASEATGAPTPPP--APPSP 798 P P +PPPE+ P P E +P S +P PP +PPSP Sbjct: 471 PEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSP 530 Query: 799 ------SAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEE 852 S PP P EE+ +PP EE PP A L + P +S + Sbjct: 531 ALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRL------SPPPEESPMSPP 584 Query: 853 AEEGP-AKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDE 911 EE P + +A E + + E S +P DS + +E Sbjct: 585 PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPM 644 Query: 912 AEGGDKNRLLSPRP--SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPR 969 + + +R LSP P S L+P P + L + + PP + +++ PP Sbjct: 645 SPPPEVSR-LSPLPVVSRLSP---------PPEESPLSPPPEESPTSPPPEASRLSPPPE 694 Query: 970 EDAAPTKPAP---PAPPPPQN---LQPESDAPQQP-GSSPRGKSRSPAPPADKEAEKPVF 1022 + +PT P P PA PPP++ P ++P P P+ RS P E+P Sbjct: 695 D--SPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHL 752 Query: 1023 FPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH-- 1080 P + P + P P + A P P S + P P P LH Sbjct: 753 SPRPEEPHLSPQAEEPHLS-----PQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLS 807 Query: 1081 -DTARPVL---PRPPTISNPP-----------PLISSAKHPSVLERQIGAISQGMSVQLH 1125 T P L P P +S P P +S S L ++ +S + Sbjct: 808 PQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELE--KPPLSPRPE 865 Query: 1126 VPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQ---AGPPESLGVPTAQE 1182 P E + P P P +P L+P G + LS G+ + PE L + + E Sbjct: 866 KPPEEPGQCPAPEELPLFPPPGEP-SLSPLLG--EPALSEPGEPPLSPLPEELPLSPSGE 922 Query: 1183 ASV 1185 S+ Sbjct: 923 PSL 925 Score = 75.5 bits (184), Expect = 6e-13 Identities = 95/361 (26%), Positives = 136/361 (37%), Gaps = 45/361 (12%) Query: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPA 794 P P AK G+ G + L A P PPPE+ +P P P T +PPP Sbjct: 409 PGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEE--SPLSPPPEESPT---SPPPE 463 Query: 795 PPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAE 854 S PP +P E + P+EE PP L+ P +S E Sbjct: 464 ASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLS-------PPPESSPFSPLE 516 Query: 855 EGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 914 E P + E L + S +P +S + +E+ + Sbjct: 517 ESPLSPPEESPPSPALETPLSPPPE----------ASPLSPPFEESPLSPPPEELPTSPP 566 Query: 915 GDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAP 974 + +R LSP P +P P + P + +L PP + + + PP E +P Sbjct: 567 PEASR-LSPPPE-ESPMSPPPEESPMSPPPEASRL------FPPFEESPLSPPPEE--SP 616 Query: 975 TKPAPPA---PPPPQNLQPESDAPQQ-PGSSPRGKSR-SPAPPADKEAEKPVFFPAFAAE 1029 P P A PPP++ P S P++ P S P SR SP P + + P P + Sbjct: 617 LSPPPEASRLSPPPED-SPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESP-LSPP 674 Query: 1030 AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPR 1089 ++ P PP S L PP E SP +P P +PP + L P+LP Sbjct: 675 PEESPTSPPPEASRLS---PPPE---DSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPL 728 Query: 1090 P 1090 P Sbjct: 729 P 729 Score = 62.8 bits (151), Expect = 4e-09 Identities = 121/468 (25%), Positives = 161/468 (34%), Gaps = 115/468 (24%) Query: 761 PPPGPPTPPPEDIPAPTEPTPASEATGAPTP------PPAPP--SPSAPPPVVPKEEKEE 812 PP PP P P PA AS GA P PP P PS P P + Sbjct: 2193 PPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSL 2252 Query: 813 ETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEG 872 + A P E V GKA EP+ S P G+ + Sbjct: 2253 DNLAVP-------------ESPGVGGGKASEPLLSP--------PPFGESRK-------- 2283 Query: 873 ALKAEKKEGGSGRATTAKSSGAPQDSDSSAT------CSADEVDEAEGGDKNRLLSPRPS 926 AL+ +K+E G+ + + DS SS T +V +A L+PR S Sbjct: 2284 ALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAP-------LTPRAS 2336 Query: 927 LLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRED----AAPTKP--APP 980 + P P PQ+P PP Q P D + T P PP Sbjct: 2337 QVEPQ-SPGLGLRPQEP-------------PPAQALAPSPPSHPDIFRPGSYTDPYAQPP 2382 Query: 981 APPPPQNLQPESDAPQQPGSSPRGK-SRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPC 1039 P PQ PES P S P SR PA P + + + P + L + C Sbjct: 2383 LTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTP------RPLSAEAFC 2436 Query: 1040 WTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPL 1099 P PV PR P++ PS P PL +P P+PP ++ Sbjct: 2437 -----PSPVTPR-FQSPDPYSRPPSRPQSRDPFAPL-------HKPPRPQPPEVAFK--- 2480 Query: 1100 ISSAKHPSVLERQI-GAISQGMSVQLH--VPYSE---HAKAPVGPVTMGLPLPM------ 1147 S H S+ A+ G + +LH VP + ++P +G P PM Sbjct: 2481 AGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQ 2540 Query: 1148 ---DPKKLAPFSGVKQEQLSP----RGQAGPPESLGVPTAQEASVLRG 1188 +P P V Q L P GP +LG P + +V G Sbjct: 2541 AVGEPSLKPP---VPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATG 2585 Score = 60.1 bits (144), Expect = 3e-08 Identities = 92/375 (24%), Positives = 126/375 (33%), Gaps = 37/375 (9%) Query: 775 APTEP--TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAE 832 +P EP TP E P + PKE + A P + G + +P Sbjct: 373 SPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEA 432 Query: 833 ELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGG---SGRATTA 889 L + P +S + EE P + + L A S + Sbjct: 433 PLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEES 492 Query: 890 KSSGAPQDSDSSATCSADEVDEAEGGDKN--RLLSPRPSLLTPTGDPRANASPQKP---- 943 S P++S S + E + P P+L TP P ASP P Sbjct: 493 PLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPP-PEASPLSPPFEE 551 Query: 944 LDLKQLKQRAAAIPPIQVTKVHEPPRED--AAPTKPAPPAPP-------PPQNLQPESDA 994 L + PP + +++ PP E + P + +P +PP PP P S Sbjct: 552 SPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPP 611 Query: 995 PQQ-PGSSPRGKSRSPAPPADK-----EAEKPVFFPAFAAEAQKLPG----DPPCWTSGL 1044 P++ P S P SR PP D E P+ P + LP PP S Sbjct: 612 PEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEES-- 669 Query: 1045 PFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAK 1104 P PP E SP +P P A +PP P P P P PL S Sbjct: 670 PLSPPPEE----SPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPL 725 Query: 1105 HPSVLERQIGAISQG 1119 P E Q+ S+G Sbjct: 726 LPLPEEPQLCPRSEG 740 Score = 59.3 bits (142), Expect = 5e-08 Identities = 160/680 (23%), Positives = 219/680 (32%), Gaps = 105/680 (15%) Query: 732 ESIPSPHTEAAKDTGQNGPKPPATLGADGPPP--GPPTPPPED------------IPAPT 777 ES SP EA++ + PP PPP P +PPPED +P P Sbjct: 677 ESPTSPPPEASRLS------PPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPE 730 Query: 778 EPTPASEATG------------APTPPPAPPSPSAPPPVVPKEEKEEETAAAP------P 819 EP + G +P P SP A P + + +E A P P Sbjct: 731 EPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSP 790 Query: 820 VEEGEEQKPPAAE-ELAVDTGKA------EEPVKSECTEEAE-----EGPAKGKDAEAAE 867 EG P E L+ T + EEP S EE+ E P E + Sbjct: 791 QAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESH 850 Query: 868 ATAEG-----ALKAEKKEGGSGRATTAKSSGA-PQDSDSSATCSADEVDEAEGGDKNRLL 921 + E + + EK G+ + P + S + E +E G+ Sbjct: 851 LSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSP 910 Query: 922 SPRPSLLTPTGDPRANAS--PQKPLDLKQLKQRAAAIPP-----------IQVTKVHEPP 968 P L+P+G+P + P PL AA PP +P Sbjct: 911 LPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPE 970 Query: 969 REDAAPTKPAPPAPPPPQN-LQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAF- 1026 AAP P +PPP N PE P SP G PA P E P P Sbjct: 971 SPLAAPILETPISPPPEANCTDPEPVPPMILPPSP-GSPVGPASPILMEPLPPQCSPLLQ 1029 Query: 1027 -AAEAQKLPG---DPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDT 1082 + Q P PP +P P+ P + + P L + Sbjct: 1030 HSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPS 1089 Query: 1083 ARPVLPRP-PTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTM 1141 A LP P +S P P + A + A G+ P + Sbjct: 1090 ATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELK 1149 Query: 1142 GLPLPMDPKKLAPFSGVK---------------QEQLSPRGQAG--PPESLGVPTAQEAS 1184 G P+ +DP++LAP + ++ +EQ PR PP + E S Sbjct: 1150 GSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEIS 1209 Query: 1185 VL-RGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP 1243 L +G A S PG G P ++ S D T + E Sbjct: 1210 NLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDD 1269 Query: 1244 SRL-DRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTY 1302 S L D G S K EG+KG S + Q GRSSS P Sbjct: 1270 SLLCDAGTAISGGKA----EGEKGRRRSSPARSRIKQ-----GRSSSFPGRRRPRGGAHG 1320 Query: 1303 DMMEGRVGRAISSASIEGLM 1322 GR +++SIE L+ Sbjct: 1321 GRGRGRARLKSTASSIETLV 1340 Score = 55.1 bits (131), Expect = 9e-07 Identities = 108/426 (25%), Positives = 138/426 (32%), Gaps = 111/426 (26%) Query: 1836 GGSSSRPASHSHAHQHSPIS-----PRTQDALQQRPSVLH----NTGMKGIITAVEPSTP 1886 GG + R S A QH+P+ P D P L+ G +T+++P P Sbjct: 354 GGQTIR----SVAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEP 409 Query: 1887 TVLRSTSTSSPVRPAAT----------------FPPATHCPLGGTLDGVYPTLMEPVLLP 1930 L+ + P+ A PP PL P P P Sbjct: 410 GPLQCEA--KPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSP------PPEESPTSPP 461 Query: 1931 KEAPRVARP--ERPRADTGHAF----------LAKPPARSGLEPA--SSPSKGSEPRPLV 1976 EA R++ P E P + A L+ PP S L P SSP E PL Sbjct: 462 PEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLS 521 Query: 1977 PPVSGHATIA-RTPAKNLAPHHASP-DPPAPPASASDPHREKTQSKPFSIQELELRSLGY 2034 PP + A TP P ASP PP + S P E S P Sbjct: 522 PPEESPPSPALETPLS--PPPEASPLSPPFEESPLSPPPEELPTSPP------------P 567 Query: 2035 HGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR-PKQPGPVKLGGEAAH 2093 S SP E SP+S P P L E L P + P+ EA+ Sbjct: 568 EASRLSPPPEE--SPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEAS- 624 Query: 2094 LPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAP 2153 L P PE P S P ++ P ++S P P Sbjct: 625 --RLSPPPEDSPMSPP-------------------------PEESPMSPPPEVSRLSPLP 657 Query: 2154 LYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGI 2213 + S L PP + L PP +P SP E + SP P + ED Sbjct: 658 VVS---------RLSPPPEESPLSPPPEESPT--SPPPEASRLSPPPEDSPTSPPPED-- 704 Query: 2214 EPVSPP 2219 P SPP Sbjct: 705 SPASPP 710 Score = 53.1 bits (126), Expect = 3e-06 Identities = 142/619 (22%), Positives = 209/619 (33%), Gaps = 102/619 (16%) Query: 1734 LVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDR 1793 L PP P+ A++ P P S SPLSP T P +S R Sbjct: 520 LSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEAS--RLSPPPE 577 Query: 1794 ERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSP 1853 E E+S ++ A P E+S S + S + SP Sbjct: 578 ESPMSPPPEESPMSPP---PEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSP 634 Query: 1854 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1913 +SP +++ P + +++ + P SP+ P Sbjct: 635 MSPPPEESPMSPPPEVSRLSPLPVVSRLSP--------PPEESPLSP------------- 673 Query: 1914 GTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGS--- 1970 P P P EA R++ P + PP S PAS P + S Sbjct: 674 -------PPEESPTSPPPEASRLSPPPEDSP------TSPPPEDS---PASPPPEDSLMS 717 Query: 1971 ---EPRPLVPPVSGHATIARTPAKNLAPH----HASPDPPAPPAS--ASDPHREKTQSKP 2021 E PL+P R+ +L+P H SP P P S A +PH +P Sbjct: 718 LPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEP 777 Query: 2022 --FSIQE---LELRSLGYHGS------SYSPEGVEP-VSPVSSPSLTHDKGLPKHLE--- 2066 ++ E L ++ G H S SP+ EP +SPV + HL Sbjct: 778 CLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQS 837 Query: 2067 -------ELDKSHLEGELR--PKQPGPVKLGGEAAHLPHLRPL----PESQPSSSPLL-Q 2112 ++SHL EL P P P K E P L P +PS SPLL + Sbjct: 838 EEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGE 897 Query: 2113 TAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPS 2172 A G + L + + + + + PLP PL P++ PP+ Sbjct: 898 PALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPL-------SPIITAAAPPA 950 Query: 2173 DLYLPPPDHGAPARGSPHSEGGKRSP--EPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRS 2230 L ++ A+G E +P E + EPV P PG Sbjct: 951 LSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVG 1010 Query: 2231 AVYPLLYRD-GEQTEP----SRMGSKSPGNTSQPPAF----FSKLTESNSAMVKSKKQEI 2281 P+L Q P S + SP + PPA S L+ + S + E+ Sbjct: 1011 PASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAEL 1070 Query: 2282 NKKLNTHNRNEPEYNISQP 2300 + ++ T +EPE +P Sbjct: 1071 H-EMETEKVSEPECPALEP 1088 Score = 53.1 bits (126), Expect = 3e-06 Identities = 27/70 (38%), Positives = 34/70 (48%), Gaps = 2/70 (2%) Query: 761 PPPGPPTPPPEDI-PAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819 PPP P+PPP + P+P P P PT P A P +P P+ E A P Sbjct: 4909 PPPEEPSPPPSPLAPSPASP-PTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARP 4967 Query: 820 VEEGEEQKPP 829 EEGE+ +PP Sbjct: 4968 PEEGEDSRPP 4977 Score = 50.8 bits (120), Expect = 2e-05 Identities = 126/637 (19%), Positives = 221/637 (34%), Gaps = 137/637 (21%) Query: 475 KNENYKSLVRRSYRRRGKSQQQQQQQQ-QQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEE 533 + + + L ++ ++ + QQQQQQQQ QQQQQQQ Q + Q+++ +++++ + ++++ Sbjct: 3913 QQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQ 3972 Query: 534 EKPEVENDKEDLLKEKTDD------------------------------TSGEDNDEKEA 563 ++ + N LL + T E N A Sbjct: 3973 QQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPA 4032 Query: 564 V---ASKGRKTANSQGRRKGRITRSMANEANSEE----------AITPQQSAELASMELN 610 V A++G T G SMA E + + PQ + +S++L Sbjct: 4033 VSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQ 4092 Query: 611 ESSRWTEEEMETAK----KGLLEHGR-------NWSAIARMVGSKTVSQCKNFYFNYKKR 659 R ++ + G HG+ S++ ++ +VS + Sbjct: 4093 PPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVS------LGDQPG 4146 Query: 660 QNLDEIL--QQHKLKMEKERNARRKKKKAPAAASEEAAFP-----PVVEDEEMEASGVSG 712 +L QQ L+ + N + K P P V + GV Sbjct: 4147 SMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLA 4206 Query: 713 NEEEM-------VEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGAD---GPP 762 ++ ++ +A + +S T ++ G LG G Sbjct: 4207 KNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGF 4266 Query: 763 PGPPTPPPEDIPAPTEP--------TPASEATGA------PTPPPAPPSPSAPPPVVPKE 808 PGP T P +++ A P P + +TG PTPPP+ P P +P Sbjct: 4267 PGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSP 4326 Query: 809 EKEEETAAAPPVEEGEEQKP-------------PAAEELAVDT------GKAEEPVKSEC 849 + T A P KP PAA +LA DT G + P Sbjct: 4327 SSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLA-DTLFSKGLGPWDPPDNLAE 4385 Query: 850 TEEAEE-----GPAKGKDAEAAEATAEGALKAEKKE---GGSGRATTAKSSGAPQDSDSS 901 T++ E+ G + + ++ ++K E +E ++ +++G P + + Sbjct: 4386 TQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGT 4445 Query: 902 ATCSADEVDEAEGGD---KNRLLSPRPSLLTPTGDPRANASPQKPLD--LKQLKQRAAAI 956 + +E G + L + L T G A +D L L+Q+ Sbjct: 4446 SNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQKLQGT 4505 Query: 957 PPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESD 993 P +EDAA K P P P+ +Q SD Sbjct: 4506 P---------SNKEDAAARK---PLTPKPKRVQKASD 4530 Score = 45.8 bits (107), Expect = 5e-04 Identities = 79/321 (24%), Positives = 103/321 (32%), Gaps = 69/321 (21%) Query: 1886 PTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRAD 1945 P V + P A +P P T YP P P + P + RP A Sbjct: 2165 PQVPAQVPSQDPFGLAPAYPLEPRFP---TAPPTYPPYPSPTGAPAQPPMLGASSRPGAG 2221 Query: 1946 TGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPA-KNLAPHHASPDPPA 2004 F PP +P S P P + P R P+ NLA P + Sbjct: 2222 QPGEFHTTPPGTPRHQP-------STPDPFLKP--------RCPSLDNLAV------PES 2260 Query: 2005 PPASASDPHREKTQSKPF----SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKG 2060 P PF E++ LG SY P + V SS TH G Sbjct: 2261 PGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSG--THLGG 2318 Query: 2061 LPKHLEELDKSHL---EGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGV 2117 L ++ K+ L ++ P+ PG LG P + L S PS + + PG Sbjct: 2319 LELKTPDVFKAPLTPRASQVEPQSPG---LGLRPQEPPPAQALAPSPPSHPDIFR--PG- 2372 Query: 2118 KGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLP 2177 YT + Q P P P P SC L R PSD + Sbjct: 2373 -------------------SYTDPYAQPPLTPRPQPP---PPESCCALPPRSLPSDPFSR 2410 Query: 2178 PPDHGAPARGSPHSEGGKRSP 2198 P SP S+ +SP Sbjct: 2411 VP-------ASPQSQSSSQSP 2424 Score = 43.5 bits (101), Expect = 0.003 Identities = 16/60 (26%), Positives = 44/60 (73%) Query: 484 RRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKE 543 ++ +++ + QQQQQQQ QQQQQ QQQ + + Q+++ +++++++ ++++++ + + ++ Sbjct: 3903 QQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQ 3962 Score = 42.4 bits (98), Expect = 0.006 Identities = 18/89 (20%), Positives = 50/89 (56%) Query: 494 QQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDT 553 QQQQQ QQQQQQQ QQQ + Q ++ +++++ + +++++ + + + +++ Sbjct: 3907 QQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQF 3966 Query: 554 SGEDNDEKEAVASKGRKTANSQGRRKGRI 582 + ++ + ++ R + Q +++ ++ Sbjct: 3967 QQQQQQQQMGLLNQSRTLLSPQQQQQQQV 3995 Score = 42.0 bits (97), Expect = 0.007 Identities = 17/64 (26%), Positives = 44/64 (68%) Query: 486 SYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL 545 S ++ + QQ QQQQQ QQQQQQQ + Q+++ +++++++ +++++ +++ ++ L Sbjct: 3896 SLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQL 3955 Query: 546 LKEK 549 +++ Sbjct: 3956 QQQQ 3959 Score = 40.0 bits (92), Expect = 0.028 Identities = 17/72 (23%), Positives = 44/72 (61%), Gaps = 2/72 (2%) Query: 491 GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKT 550 G QQ QQQQQ QQQQQ QQ + Q++ ++ ++++ ++++++ +++ ++ L+++ Sbjct: 3895 GSLQQLQQQQQLQQQQQLQQQQQQQLQQQ--QQLQQQQLQQQQQQQQLQQQQQQQLQQQQ 3952 Query: 551 DDTSGEDNDEKE 562 + +++ Sbjct: 3953 QQLQQQQQQQQQ 3964 Score = 39.3 bits (90), Expect = 0.048 Identities = 72/341 (21%), Positives = 119/341 (34%), Gaps = 53/341 (15%) Query: 710 VSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPP 769 ++G+E +++ + ++ + D + I + H + + + G + P GP P Sbjct: 3042 LNGDEFDLLAYTDPELD-TGDKKDIFNEHLRLVESANEKAEREALLRGVEPGPLGPEERP 3100 Query: 770 PEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKE-------EETAAAPPVEE 822 P PA++A+ P S P V PK E+ + T A P VE Sbjct: 3101 P----------PAADAS-------EPRLASVLPEVKPKVEEGGRHPSPCQFTIATPKVEP 3143 Query: 823 GEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGP--AKGKDAEAAEATAEGALKAE--- 877 PAA L + + + S T GP + G AE A A G A Sbjct: 3144 A-----PAANSLGLGLKPGQSMMGSRDTRMG-TGPFSSSGHTAEKASFGATGGPPAHLLT 3197 Query: 878 ----KKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGD 933 GGS + S DE+D+ E + + S P L+ Sbjct: 3198 PSPLSGPGGSSLLEKFELESGALTLPGGPAASGDELDKME---SSLVASELPLLI----- 3249 Query: 934 PRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESD 993 + + +L++ +Q +A + P Q + + + PA P + P Sbjct: 3250 --EDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLA 3307 Query: 994 APQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLP 1034 QQ S +R P P +P PA A + + P Sbjct: 3308 GSQQQLSLGLAGARQPGLPQPLMPTQP---PAHALQQRLAP 3345 Score = 39.3 bits (90), Expect = 0.048 Identities = 130/684 (19%), Positives = 227/684 (33%), Gaps = 127/684 (18%) Query: 492 KSQQQQQQQQQQQ---------QQQQQQPMPRSSQEEKDEKE------KEKEAEKEEEKP 536 K QQQQQQQQQQQ QQQQQ P +++Q + + + ++ P Sbjct: 3733 KLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQLSP 3792 Query: 537 EVENDKEDLL--------KEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGR--ITRSM 586 + + +L +++ G ++ + ++ R ++ Q ++G+ + + Sbjct: 3793 QPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRL 3852 Query: 587 ANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGS-KT 645 ++ QQ +A + + S L+ H A+ +GS + Sbjct: 3853 VTAQQQQQQQQHQQQGSMAGLSHLQQS-------------LMSHSGQPKLSAQPMGSLQQ 3899 Query: 646 VSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEM 705 + Q + + +Q + LQQ + +++ ++++++ ++ ++ Sbjct: 3900 LQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQ 3959 Query: 706 EASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGP 765 + +++ ++ + + N S T P + G P P + GP Sbjct: 3960 QQQQQQFQQQQ--QQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGP 4017 Query: 766 PTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEE 825 +P +SEAT P+ P P E E P G+ Sbjct: 4018 TLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTP----ESMATEPGEVKPSLSGDS 4073 Query: 826 QKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGR 885 Q L V +P + P + + + TA G + G S Sbjct: 4074 QL------LLVQPQPQPQPSSLQLQPPLRL-PGQQQQQVSLLHTAGGGSHGQLGSGSSSE 4126 Query: 886 ATT-----AKSSGAPQDSDSSATCSA----DEVDEAEGGDKNRLLSPRPS---------- 926 A++ A+ S + D S T + + E + P+P Sbjct: 4127 ASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLP 4186 Query: 927 ---LLTPTGDPRA-------------NASPQKPLDL------KQLKQRAAA--IPPIQVT 962 ++ G RA + SPQ+ L +QL+Q A PP Q Sbjct: 4187 GVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEP 4246 Query: 963 KVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQP---GSSPRGKSRSPAPPADKEAEK 1019 P + +P P PQ P Q G P+G R PAPP + Sbjct: 4247 GTQTSPLQGLLGCQPQLGGFPGPQT------GPLQELGAGPRPQGPPRLPAPPG-ALSTG 4299 Query: 1020 PVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGL 1079 PV P P PP S P P ++ S P + PG P P G Sbjct: 4300 PVLGPVH-------PTPPP---SSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQG- 4348 Query: 1080 HDTARPVLPRPPTISNPPPLISSA 1103 PT+ PP +S A Sbjct: 4349 -----------PTLEPPPGRVSPA 4361 Score = 36.6 bits (83), Expect = 0.31 Identities = 66/250 (26%), Positives = 90/250 (36%), Gaps = 22/250 (8%) Query: 1518 PVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREP--TPRLQEGSLSSSKASQDRK 1575 P + P+ P SP E H +P P SPV EP +P+ +E LS S++ Sbjct: 786 PHLSPQAEGPHLSPQPEELHLSPQTEE-PHLSPVP-EEPCLSPQPEESHLSPQ--SEEPC 841 Query: 1576 LTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLD 1635 L+ P E SP P P P P E G +PL F P P PL Sbjct: 842 LSPRPEESHLSPELEKPPLSPRPEKPPEE-----PGQCPAPEELPL-FPPPGEPSLSPLL 895 Query: 1636 AAAAYYLPRH--LAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAATA 1693 A P L+P P L P P + ++ IT+ + Sbjct: 896 GEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLG 955 Query: 1694 MAQRADMLRGLSPRESSLALNYAAGP------RGIIDLSQVPHLPVLVPPTPGTPATAMD 1747 + +G S ES LA P D VP P+++PP+PG+P Sbjct: 956 ELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVP--PMILPPSPGSPVGPAS 1013 Query: 1748 RLAYLPTAPQ 1757 + P PQ Sbjct: 1014 PILMEPLPPQ 1023 Score = 35.8 bits (81), Expect = 0.53 Identities = 102/459 (22%), Positives = 158/459 (34%), Gaps = 85/459 (18%) Query: 720 EAEATVNNSSDTESIPSPHTEAAKDTGQNGPKP-----PATLGADG---PPPGPPTPPPE 771 E A V + + SP T A T P P P +G P P P PPP Sbjct: 2505 ELHAKVPSGQPPNFVRSPGTGAFVGT----PSPMRFTFPQAVGEPSLKPPVPQPGLPPPH 2560 Query: 772 DI-----PAPTEPTPASE----ATGAPTPPPAPPSPSA-------------PPPVVPKEE 809 I P PT P S ATG P +P PS+ PP V+P Sbjct: 2561 GINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPA 2620 Query: 810 KE-----------EETAAAPPVEEGEEQKPPAAEELAV-DTGKAEEPVKSECTE---EAE 854 + + + PVE+ E+ LA + ++P S ++ E + Sbjct: 2621 PDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQ 2680 Query: 855 EGPAKGKDAEAAEATAEGALKAEKKEGGS--GRATTAKSSGAPQDSDSSATCSADEVDEA 912 + ++ + L+ EK+ + G S GA S + S + A Sbjct: 2681 RQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFA 2740 Query: 913 EGGDKNRLLSPRPSLLT-PTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRED 971 DK+ L+ PS L+ P P + P D + + A P + Sbjct: 2741 GTQDKSSLVGLPPSKLSGPILGPGSF-----PSDDRLSRPPPPATPSSMDVNSRQLVGGS 2795 Query: 972 AAPTKPAP-PAPPPPQNLQPESDAPQQPGSSPRGK----SRSPAPPADKEAEKPVFFPAF 1026 A + AP P P Q Q + QQ ++ + +R P+ P + + + P Sbjct: 2796 QAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSP-L 2854 Query: 1027 AAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHA-----PDPSAF-SYAPPGHP------ 1074 A + +LPG +P P P + I+ + P + F PP P Sbjct: 2855 AGISTRLPGPG----EPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVS 2910 Query: 1075 ------LPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1107 P GL A LP + P P ++++ HP+ Sbjct: 2911 EDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPT 2949 Score = 35.4 bits (80), Expect = 0.70 Identities = 52/174 (29%), Positives = 64/174 (36%), Gaps = 22/174 (12%) Query: 61 PQRRRPSLLSEFQPGNERSQELHL-RPESHSYL-PELGKSEMEFIESKRPRLELLPDPLL 118 P+ R S E P + + LHL RP S L P +S + P E P L Sbjct: 462 PEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLS------PPPESSPFSPL 515 Query: 119 RPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPP------SPPHTDPELELVPP----RLS 168 SPL + S L S + P+SPP SPP EL PP RLS Sbjct: 516 EESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPP--PEELPTSPPPEASRLS 573 Query: 169 KEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESK 222 M E M + + EE PP E P+SPPP S+ Sbjct: 574 PPPEESPMSPPPEESPMSPPP--EASRLFPPFEESPLSPPPEESPLSPPPEASR 625 Score = 34.7 bits (78), Expect = 1.2 Identities = 27/103 (26%), Positives = 37/103 (35%), Gaps = 2/103 (1%) Query: 120 PSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRV 179 P PL +P G + + L L P PP + L PP S R+ Sbjct: 409 PGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLS-PPPEESPTSPPPEASRL 467 Query: 180 DREIT-MVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIES 221 + + + + LEE PP E P+SPPP S Sbjct: 468 SPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESS 510 Score = 34.7 bits (78), Expect = 1.2 Identities = 90/391 (23%), Positives = 121/391 (30%), Gaps = 65/391 (16%) Query: 1900 PAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSG 1959 P P H G L PTL+ L KE V A G + P G Sbjct: 3999 PGMPAKPLQHFSSPGALG---PTLL---LTGKEQNTVDPAVSSEATEGPSTHQGGPLAIG 4052 Query: 1960 LEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASAS-DPHREKTQ 2018 P S +EP + P +SG + + P P P+S P Sbjct: 4053 TTPESM---ATEPGEVKPSLSGDSQLLLV----------QPQPQPQPSSLQLQPPLRLPG 4099 Query: 2019 SKPFSIQELELRSLGYHG---SSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2075 + + L G HG S S E ++ PS++ L + S + Sbjct: 4100 QQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVS--------LGDQPGSMTQN 4151 Query: 2076 ELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ---HISE 2132 L P+QP P P P+LQ+ G+ G + T+ Q + Sbjct: 4152 LLGPQQP--------MLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQG 4203 Query: 2133 VITQDYTRHH-----PQQLSAPL------------PAPLYSFPGASCPVLD--LRRPPSD 2173 V+ ++ H QQL A L P Y PG L L P Sbjct: 4204 VLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQL 4263 Query: 2174 LYLPPPDHGAPAR--GSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSA 2231 P P G P +G R P P G + P PP EP Sbjct: 4264 GGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQL 4323 Query: 2232 VYPLLYRDGE-QTEPSRMGSKSP-GNTSQPP 2260 P E Q P+ G+ P G T +PP Sbjct: 4324 PSPSSQLPTEAQLPPTHPGTPKPQGPTLEPP 4354 Score = 34.3 bits (77), Expect = 1.6 Identities = 40/123 (32%), Positives = 51/123 (41%), Gaps = 11/123 (8%) Query: 47 RDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQE---LHLRPESHSYLPELGKSEMEFI 103 R SHLSP P RP E +PG + E L P S P LG+ + Sbjct: 845 RPEESHLSPELEKPPLSPRPEKPPE-EPGQCPAPEELPLFPPPGEPSLSPLLGEPALS-- 901 Query: 104 ESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEP-VSPPSPPHTDPELEL 162 E P L LP+ L PL +G+P+ S L L L P ++ +PP P EL Sbjct: 902 EPGEPPLSPLPEEL----PLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGEL 957 Query: 163 VPP 165 P Sbjct: 958 EYP 960 Score = 34.3 bits (77), Expect = 1.6 Identities = 115/501 (22%), Positives = 166/501 (33%), Gaps = 96/501 (19%) Query: 727 NSSDTESIP----SPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPA-PTEPTP 781 +SS +S P SP ++ + G P+P G P P T P+ PT PT Sbjct: 1937 SSSPMDSYPGLCQSPFLDSRERGGFFSPEP-------GEPDSPWTGSGGTTPSTPTTPTT 1989 Query: 782 ASEATGAPTPPPAPPSPSAPPPVVPKEEKEEET---AAAPPVEEGEEQKPPAAEELAVDT 838 E G S + + EK+EE + PV P ++ + Sbjct: 1990 EGEGDGL----------SYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWS 2039 Query: 839 GKAEEPVKS-ECTEEAEEGP--AKGKDAEAA------EATAEGALKAEKKEGGSGRATTA 889 + ++ +K A++ P K KD AA + AE + + K G R T Sbjct: 2040 SRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDR 2099 Query: 890 KS-----------------SGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTG 932 + + AP S T A A+G L P P G Sbjct: 2100 PALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADG-----FLKP------PAG 2148 Query: 933 DPRANASPQKPLDLKQLKQRAAAIP---PIQVTKVH--EPPREDAAPTKPAPPAPPPPQN 987 SP + L LK Q A +P P + + EP A PT P P+P Sbjct: 2149 SVPGPDSPGE-LFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPA 2207 Query: 988 LQPESDAPQQPGSSPRGK--SRSPAPPADKEAEKPVFFPAFAAEAQKL--PGDPPC--WT 1041 P A +PG+ G+ + P P + + F L P P Sbjct: 2208 QPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGK 2267 Query: 1042 SGLPFPVPP-----REVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP 1096 + P PP R+ ++ S+ SY PP LG D+ Sbjct: 2268 ASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPN----LGFVDSPSSGTHLGGLELKT 2323 Query: 1097 PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLP---MDPKKLA 1153 P + + P Q+ S G+ ++ P A AP P + P DP Sbjct: 2324 PDVFKAPLTPRA--SQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDP---- 2377 Query: 1154 PFSGVKQEQLSPRGQAGPPES 1174 Q L+PR Q PPES Sbjct: 2378 ----YAQPPLTPRPQPPPPES 2394 Score = 34.3 bits (77), Expect = 1.6 Identities = 73/301 (24%), Positives = 102/301 (33%), Gaps = 52/301 (17%) Query: 1816 PIWRPGTEQSSGSSGSSGGGG-------GSSSRPASHSHAHQHSPIS------PRTQDAL 1862 P+ PG +Q S + GGG GSSS +S H +S TQ+ L Sbjct: 4094 PLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLL 4153 Query: 1863 QQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTL------ 1916 + +L T +P P + + P L G L Sbjct: 4154 GPQQPMLERPMQNN--TGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQL 4211 Query: 1917 --------DGVYPTLMEPVLLPKEAPRVARP-ERPRADTG--HAFLAKPPARSGLE-PAS 1964 + LM+ L +A R P + P T L P G P + Sbjct: 4212 RHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQT 4271 Query: 1965 SPSK--GSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPF 2022 P + G+ PRP PP A + L P H +P PP+S +P R P Sbjct: 4272 GPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTP----PPSSPQEPKRPSQLPSPS 4327 Query: 2023 SIQELELRSLGYHGSSYSPEG--VEP----VSPVSS--PSLTHDKGL-----PKHLEELD 2069 S E + H + P+G +EP VSP ++ KGL P +L E Sbjct: 4328 SQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQ 4387 Query: 2070 K 2070 K Sbjct: 4388 K 4388 Score = 33.5 bits (75), Expect = 2.7 Identities = 15/17 (88%), Positives = 15/17 (88%) Query: 490 RGKSQQQQQQQQQQQQQ 506 R K QQQQQQQQQQQQQ Sbjct: 3596 RNKQQQQQQQQQQQQQQ 3612 Score = 33.1 bits (74), Expect = 3.5 Identities = 69/310 (22%), Positives = 101/310 (32%), Gaps = 41/310 (13%) Query: 750 PKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEE 809 P PP + A PP P+ P +PA P S + TP P P PV P+ + Sbjct: 2389 PPPPESCCAL-PPRSLPSDPFSRVPA--SPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQ 2445 Query: 810 KEEETAAAPPVEEGEE-----QKPPAAE--ELAVDTGKAEEPVKSECTEEAEEGPAKGKD 862 + + P + + KPP + E+A G A G Sbjct: 2446 SPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSL-----------AHTSLGAGGF 2494 Query: 863 AEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLS 922 A A G L A+ G + +GA + S + +A G + Sbjct: 2495 PAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFT---FPQAVGEPSLKPPV 2551 Query: 923 PRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAI-------PPIQVTKVHEPPREDAAPT 975 P+P L P G ++ P L Q A P+ + +P Sbjct: 2552 PQPGLPPPHG-INSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPL 2610 Query: 976 KPAPPAPPPPQNLQPESDAPQ-QPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLP 1034 +P PPP P+ P G+S R SP ++ E P + +LP Sbjct: 2611 RPPSVLPPP----APDGSLPYLSHGASQRSGITSPV----EKREDPGTGMGSSLATAELP 2662 Query: 1035 GDPPCWTSGL 1044 G SGL Sbjct: 2663 GTQDPGMSGL 2672 Score = 33.1 bits (74), Expect = 3.5 Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 3/45 (6%) Query: 474 KKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQE 518 +K + + + YR + QQQQQQQQQQQQQQ + S + Sbjct: 3582 RKQQKEHTNLMAEYRNK---QQQQQQQQQQQQQQHSAVLALSPSQ 3623 >gi|95147555 microtubule-associated protein 1A [Homo sapiens] Length = 2803 Score = 83.2 bits (204), Expect = 3e-15 Identities = 266/1240 (21%), Positives = 442/1240 (35%), Gaps = 255/1240 (20%) Query: 59 IQPQRRRPSLLSEFQPGNERSQEL---HLRPESHSYLP----ELGKSEMEFIESKRPRLE 111 + P+ + LSE P E S ++ L PES L LGK EM + Sbjct: 1189 VSPEDTQSLSLSEESPSKETSLDVSSKQLSPESLGTLQFGELNLGKEEMGHLMQAEDTSH 1248 Query: 112 LLPDPLLRPSPLLATGQP--------AGSEDLTKDRSLTGKLEPVSPPSP---------- 153 P+ P P AT P + D+T D L+ SP S Sbjct: 1249 HTA-PMSVPEPHAATASPPTDGTTRYSAQTDITDD-----SLDRKSPASSFSHSTPSGNG 1302 Query: 154 -----PHTDPELELVPPRLSKEELIQNMDRVDREITMV--EQQISKLKKKQQQLEEEAAK 206 T P+ ++ P S + +++ E + E ++ LK + + ++E Sbjct: 1303 KYLPGAITSPDEHILTPDSSFSKSPESLPGPALEDIAIKWEDKVPGLKDRTSEQKKE--- 1359 Query: 207 PPEPEKPVSPPPIES-KHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQ 265 PEP+ V ++ +H+ +V+ +K EA H E + Q + L + D Q Sbjct: 1360 -PEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAVKQQ-DKALEQKGRDLEQ 1417 Query: 266 YHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLME----AWEKKVERIENNPR 321 ++ + + ++ A +Q + K + D+ +E A E+K + +E + Sbjct: 1418 KDTALEQKDKALEPKDKDLEEKDKALEQ-KDKIPEEKDKALEQKDTALEQKDKALEPKDK 1476 Query: 322 RRAKESKVREYYEKQFPEIRKQRELQERMQS-----------RVGQRGSGLSMSAARSEH 370 ++ +V E EK PE K + L ++++S + R + A +H Sbjct: 1477 DLEQKDRVLEQKEK-IPE-EKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKH 1534 Query: 371 EVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMN 430 + E D +SE+++ + + A+ +A +Q I+ + N + + ++ + Sbjct: 1535 QAQEQKDKVSEKKDQALEQKYWAL--GQKDEALEQNIQALEENHQTQEQESLVQEDKTRK 1592 Query: 431 MWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRR 490 +EK + K M+ + + LE+ TK +SLV+ Sbjct: 1593 PKMLEEKSPEKVKAMEEK-----LEALLEK------------TKALGLEESLVQE----- 1630 Query: 491 GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN----DKEDLL 546 G++++Q+++ + Q Q+ ++EE ++KE E+ PE +N +ED+ Sbjct: 1631 GRAREQEEKYWRGQDVVQEWQETSPTREEPAGEQKELAPAWEDTSPEQDNRYWRGREDVA 1690 Query: 547 KEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELAS 606 E+ DT + + V + QG R P + E S Sbjct: 1691 LEQ--DTYWRELSCERKVWFP--HELDGQGAR-------------------PHYTEERES 1727 Query: 607 MELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFY-FNYKKRQNLDEI 665 L+E ++E E L EH S S K+F + +K ++ Sbjct: 1728 TFLDEG---PDDEQEVP---LREHATR---------SPWASDFKDFQESSPQKGLEVERW 1772 Query: 666 LQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATV 725 L + + + E K ++P A PP + + + ++ G E + + + Sbjct: 1773 LAESPVGLPPEE--EDKLTRSPFEIISPPASPPEMVGQRVPSA--PGQESPIPD--PKLM 1826 Query: 726 NNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPED-IPAP-------T 777 + + + PS + ++ P PPA L P PGPPTP PE PAP Sbjct: 1827 PHMKNEPTTPSWLADIPPWVPKDRPLPPAPL---SPAPGPPTPAPESHTPAPFSWGTAEY 1883 Query: 778 EPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQK-PPAAEELAV 836 + A+ GA P SP + E+EEE A P + K P A++ A Sbjct: 1884 DSVVAAVQEGAAELEGGPYSPLGKDYRKAEGEREEEGRAEAPDKSSHSSKVPEASKSHAT 1943 Query: 837 DTGKAEEPVKSECTEEAEE-----------------GPAKGKDAEAAEATAEGALKAEKK 879 + EP + E T +E GPA A + K Sbjct: 1944 TEPEQTEPEQREPTPYPDERSFQYADIYEQMMLTGLGPACPTREPPLGAAGDWPPCLSTK 2003 Query: 880 EGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPR--------PSLLTPT 931 E +GR T+A+ + S S +D + + PR PSL P Sbjct: 2004 EAAAGRNTSAEKELSSPISPKS--LQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLTPPA 2061 Query: 932 GDPRA---NASPQKPL--DLKQLKQRAAAIPPIQVTKVH---------------EPPRED 971 PRA + P PL ++ + P + + H E P ++ Sbjct: 2062 VPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKE 2121 Query: 972 AAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQ 1031 A P P P L PE++A P P PA P+ + FPA A Sbjct: 2122 AQSPSPPHPIPMGSPTLWPETEAHVSP---PLDSHLGPARPS-------LDFPASAFGFS 2171 Query: 1032 KLPGDPPCWTSGLPFPVPPR-------------------------------EVIKAS--- 1057 L PP LP P PR EV KA Sbjct: 2172 SLQPAPP----QLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLD 2227 Query: 1058 ---PHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKH---PSV--L 1109 P P PS+ PG PL L A P L + P+ISS PS+ Sbjct: 2228 SSLPQLPSPSS-----PGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSLEAA 2282 Query: 1110 ERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDP 1149 E++ G + GM H + +P P ++ L L P Sbjct: 2283 EQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLALAPAP 2322 Score = 73.9 bits (180), Expect = 2e-12 Identities = 203/1027 (19%), Positives = 364/1027 (35%), Gaps = 139/1027 (13%) Query: 309 WEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMS--AA 366 WE KV +++ + KE + ++ +Q + + +E+ E + + Q+ L + A Sbjct: 1342 WEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAV 1401 Query: 367 RSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDAD-QQRIKFINMNGLMADPMKVYKD 425 + + + E EQ++ + + A+ P D D +++ K + D + KD Sbjct: 1402 KQQDKALEQKGRDLEQKDTALEQKDKALEPK---DKDLEEKDKALEQK----DKIPEEKD 1454 Query: 426 RQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVR- 484 + + ++K+T E Q K LE+K + VL E K+L + Sbjct: 1455 KAL------EQKDTALE---QKDKALEPKDKDLEQK---DRVLEQKEKIPEEKDKALDQK 1502 Query: 485 -RSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKE 543 RS + + + + +Q + P + +E+ +K EK+ + E+K K+ Sbjct: 1503 VRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKD 1562 Query: 544 DLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAE 603 + L++ +++ + KT + + + A E E + ++ Sbjct: 1563 EALEQNIQALEENHQTQEQESLVQEDKTRKPKMLEEKSPEKVKAMEEKLEALLEKTKALG 1622 Query: 604 LASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSK----------TVSQCKNFY 653 L + E +EE + +++ + S + T + N Y Sbjct: 1623 LEESLVQEGRAREQEEKYWRGQDVVQEWQETSPTREEPAGEQKELAPAWEDTSPEQDNRY 1682 Query: 654 FNYKKRQNLDEILQQHKLKMEKE----RNARRKKKKAPAAASEEAAFPPVVEDEEME--- 706 + ++ L++ +L E++ + + E+ F D+E E Sbjct: 1683 WRGREDVALEQDTYWRELSCERKVWFPHELDGQGARPHYTEERESTFLDEGPDDEQEVPL 1742 Query: 707 ---------ASGVSGNEEEMVEE--------AEATVNNSSDTE--------SIPSPHTEA 741 AS +E ++ AE+ V + E I SP Sbjct: 1743 REHATRSPWASDFKDFQESSPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASP 1802 Query: 742 AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAP 801 + GQ P P G + P P P P T A P P PP+P +P Sbjct: 1803 PEMVGQRVPSAP---GQESPIPDPKLMPHMKNEPTTPSWLADIPPWVPKDRPLPPAPLSP 1859 Query: 802 PPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGK 861 P P E T A P G + + + E S ++ + + + Sbjct: 1860 APGPPTPAPESHTPA--PFSWGTAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGERE 1917 Query: 862 DAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLL 921 + AEA + + ++ E ATT P+ + + A+ ++ L Sbjct: 1918 EEGRAEAPDKSSHSSKVPEASKSHATTEPEQTEPEQREPTPYPDERSFQYADIYEQMMLT 1977 Query: 922 SPRPSLLTPTGDPRANASPQKP--LDLKQL---------KQRAAAIPPIQVTKVHEPPRE 970 P+ PT +P A+ P L K+ K+ ++ I P + + P Sbjct: 1978 GLGPA--CPTREPPLGAAGDWPPCLSTKEAAAGRNTSAEKELSSPISP-KSLQSDTPTFS 2034 Query: 971 DAAPTKP-APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAE 1029 AA P PP P P +++P P P +P S+ P+PP + + Sbjct: 2035 YAALAGPTVPPRPEPGPSMEPSLTPPAVPPRAPI-LSKGPSPPLNGNI-------LSCSP 2086 Query: 1030 AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPR 1089 ++ P S E+ K + P+ A S +PP HP+P+G P L Sbjct: 2087 DRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKEAQSPSPP-HPIPMG-----SPTL-W 2139 Query: 1090 PPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDP 1149 P T ++ P + S P+ L P S + + P LP P +P Sbjct: 2140 PETEAHVSPPLDSHLGPA-------------RPSLDFPASAFGFSSLQPAPPQLPSPAEP 2186 Query: 1150 KKLAP-----FSGVKQEQLSPRGQAGPP------ESLGVPTAQEA-SVLRGTALGSVPGG 1197 + AP FSG + L+P GPP E L V A S L S PG Sbjct: 2187 RS-APCGSLAFSGDRALALAP----GPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSSPGA 2241 Query: 1198 SITKGIPSTRVPSDSAITYRGSITHGTP--ADVLYKGTITRIIGEDSPSRLDRGREDSLP 1255 + +P P+ A++ S TP + V + + + E LD G E P Sbjct: 2242 PLLSNLPR---PASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGELDPGME---P 2295 Query: 1256 KGHVIYE 1262 H +++ Sbjct: 2296 AAHSLWD 2302 Score = 47.0 bits (110), Expect = 2e-04 Identities = 142/663 (21%), Positives = 210/663 (31%), Gaps = 117/663 (17%) Query: 729 SDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGA 788 S E+ +T A K+ + P P +L +D P +P EP P+ E + Sbjct: 2001 STKEAAAGRNTSAEKEL--SSPISPKSLQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLT 2058 Query: 789 P--TPPPAPPSPSAPPPVVPKE--EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP 844 P PP AP P P + + + P E G + + ++ G E+P Sbjct: 2059 PPAVPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQP 2118 Query: 845 VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEG---------GSGRATTAKSSGAP 895 K + G E A + + G S ++ P Sbjct: 2119 EKEAQSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPSLDFPASAFGFSSLQPAPP 2178 Query: 896 QDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP-RANASPQKPLDLKQLKQRAA 954 Q + SA A GD+ L+P P T + +P L QL ++ Sbjct: 2179 QLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSS 2238 Query: 955 AIPPI--QVTKVHEPPREDAAPTKPAPPA-PPPPQNLQPESDAPQQ------PGSSPRGK 1005 P+ + + P + + ++ P + P +A +Q PG P Sbjct: 2239 PGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGELDPGMEPAAH 2298 Query: 1006 SR------SPAPPADKEAEKPVFFPAFAAEAQKLPGDP-----PCWTS--------GLPF 1046 S SPAPPA + A A LPGD PC PF Sbjct: 2299 SLWDLTPLSPAPPASLDLA--------LAPAPSLPGDMGDGILPCHLECSEAATEKPSPF 2350 Query: 1047 PVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLP---------------RPP 1091 VP + P P+ PPG P P + P RP Sbjct: 2351 QVPSEDCAANGPTETSPN-----PPG-PAPAKAENEEAAACPAWERGAWPEGAERSSRPD 2404 Query: 1092 TISNPP----PLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPM 1147 T+ +P P S PS ++ A QG + + E + + + P LP + Sbjct: 2405 TLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATEPRPHRGELSPSFLNPP---LPPSI 2461 Query: 1148 DPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTR 1207 D + L+ E++ G+ G +G P GT G P +T P T Sbjct: 2462 DDRDLST------EEVRLVGRGGR-RRVGGP---------GTTGGPCP---VTDETPPTS 2502 Query: 1208 VPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGH 1267 SDS + S P + E+ PS DS G + K G Sbjct: 2503 A-SDSGSSQSDS---DVPPET-----------EECPSITAEAALDSDEDGDFLPVDKAGG 2547 Query: 1268 VLSYEG---GMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGR 1324 V G + D R S P A GRV R ++G +GR Sbjct: 2548 VSGTHHPRPGHDPPPLPQPDPRPSPPRPDVCMADPEGLSSESGRVERLREKEKVQGRVGR 2607 Query: 1325 AIP 1327 P Sbjct: 2608 RAP 2610 Score = 45.8 bits (107), Expect = 5e-04 Identities = 92/395 (23%), Positives = 136/395 (34%), Gaps = 84/395 (21%) Query: 726 NNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT-----PPPEDIPAPTEPT 780 +++SD+E + K+ P PP + P P T PP + P P+ Sbjct: 2103 DSTSDSELEKGAREQPEKEA--QSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPS 2160 Query: 781 ---PASEATGAPTPPPAPP---SPSAP---------------------PPVVPKEEKEEE 813 PAS A G + PAPP SP+ P PP + ++ E Sbjct: 2161 LDFPAS-AFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLE 2219 Query: 814 TAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEG- 872 AP ++ Q P + A P+ S A ++G +EA Sbjct: 2220 VTKAPSLDSSLPQLPSPSSPGA--------PLLSNLPRPASPALSEGSSSEATTPVISSV 2271 Query: 873 ------ALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 926 +L+A ++E G ++ + D + +D A L+P PS Sbjct: 2272 AERFSPSLEAAEQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLA--------LAPAPS 2323 Query: 927 LLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAA---PTKPAP---- 979 L GD P L+ + P QV P ED A PT+ +P Sbjct: 2324 LPGDMGDGIL------PCHLECSEAATEKPSPFQV------PSEDCAANGPTETSPNPPG 2371 Query: 980 PAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPC 1039 PAP +N + + + G+ P G RS P E+PV PA + G PP Sbjct: 2372 PAPAKAENEEAAACPAWERGAWPEGAERSSRPDTLLSPEQPV-CPAGGS------GGPPS 2424 Query: 1040 WTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHP 1074 S P + PH + S PP P Sbjct: 2425 SASPEVEAGPQGCATEPRPHRGELSPSFLNPPLPP 2459 Score = 45.1 bits (105), Expect = 9e-04 Identities = 140/624 (22%), Positives = 206/624 (33%), Gaps = 138/624 (22%) Query: 1518 PVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRLQEGSL---SSSKASQDR 1574 P + P PR +P+ + P G++ SP R P+P+ S S+S + ++ Sbjct: 2055 PSLTPPAVPPR-APILSKGPSPPLNGNILSCSP-DRRSPSPKESGRSHWDDSTSDSELEK 2112 Query: 1575 KLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPL 1634 P + A+SP PHPI L + +H+ D P L Sbjct: 2113 GAREQPEKEAQSPSP------PHPIPMGSPTLWPET-----EAHVSPPLDSHLGPARPSL 2161 Query: 1635 DAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAATAM 1694 D A+ + L P P P L P R P ++ Sbjct: 2162 DFPASAFGFSSLQPAP--PQLPSPAEPRSAP-------------------------CGSL 2194 Query: 1695 AQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPT 1754 A D L+P + + +++++ P L +P P + L+ LP Sbjct: 2195 AFSGDRALALAPGPPTRTRHDE-----YLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLP- 2248 Query: 1755 APQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEH 1814 R +S LS G + T P +S +ER Sbjct: 2249 -------RPASPALSEGSSSEATTPVISSVAER--------------------------- 2274 Query: 1815 APIWRPGTEQSSGSSGSSGGGGGSSSRPASHS--HAHQHSPISPRTQD-ALQQRPSVLHN 1871 + P E + SG G PA+HS SP P + D AL PS+ + Sbjct: 2275 ---FSPSLEAAEQESGELDPG----MEPAAHSLWDLTPLSPAPPASLDLALAPAPSLPGD 2327 Query: 1872 TGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPK 1931 G GI+ P L S ++ +P+ P+ C G PT P P Sbjct: 2328 MG-DGIL-------PCHL-ECSEAATEKPSPFQVPSEDCAANG------PTETSP-NPPG 2371 Query: 1932 EAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPV--SGHATIARTP 1989 AP A E A A P G E +S P P V P SG + +P Sbjct: 2372 PAPAKAENEEAAACPAWERGAWP---EGAERSSRPDTLLSPEQPVCPAGGSGGPPSSASP 2428 Query: 1990 AKNLAPHHASPDP-----PAPPASASDPHREKTQSKPFSIQELEL------RSLGYHGSS 2038 P + +P P+ + P + S +E+ L R +G G++ Sbjct: 2429 EVEAGPQGCATEPRPHRGELSPSFLNPPLPPSIDDRDLSTEEVRLVGRGGRRRVGGPGTT 2488 Query: 2039 YSP----EGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG---PVKLGGEA 2091 P + P S S S D +P EE E L + G PV G Sbjct: 2489 GGPCPVTDETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGV 2548 Query: 2092 AHLPHLR------PLPESQPSSSP 2109 + H R PLP+ P SP Sbjct: 2549 SGTHHPRPGHDPPPLPQPDPRPSP 2572 Score = 41.6 bits (96), Expect = 0.010 Identities = 84/449 (18%), Positives = 162/449 (36%), Gaps = 47/449 (10%) Query: 475 KNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEE 534 ++E K L + + + S++ ++ + ++ + + +++ K K+K + +E+ Sbjct: 349 RSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEK 408 Query: 535 KPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEE 594 ++E K+ KEK + +K+ + +K A + +RK + Sbjct: 409 ISKLEEKKD---KEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELKKISKPDLK 465 Query: 595 AITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYF 654 TP+ L ++ + +K L + A V T+S + Sbjct: 466 PFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEPQTPPAQKGTVPLPTISGHRELVL 525 Query: 655 NYKK--RQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSG 712 + + Q+ +E+ ++ + + ++R+ K P +EE ++ G+ G Sbjct: 526 SSPEDLTQDFEEMKREERALLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGL-G 584 Query: 713 NEEEMVEEAEAT-----VNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT 767 EE +++E E S D TE KDT + + A Sbjct: 585 QEEHVMKEKELVPEVPEEQGSKDRGLDSGAETEEEKDTWEEKKQREA------------- 631 Query: 768 PPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQK 827 E +P TE SE P V+ K E EE P EE E+ Sbjct: 632 ---ERLPDRTEAREESE-------------PEVKEDVIEKAELEEMEEVHPSDEEEED-- 673 Query: 828 PPAAEELAVDTGKAEEPVK-SECTEEAEEGPAKGKDAEAAEATAEGALKA-EKKEGGSGR 885 A + +EP+K + + EA G G +A E L + G + Sbjct: 674 --ATKAEGFYQKHMQEPLKVTPRSREAFGGRELGLQGKAPEKETSLFLSSLTTPAGATEH 731 Query: 886 ATTAKSSGAPQDSDSSATCSADEV-DEAE 913 + + P S++ T S +E+ DE E Sbjct: 732 VSYIQDETIPGYSETEQTISDEEIHDEPE 760 Score = 35.4 bits (80), Expect = 0.70 Identities = 64/272 (23%), Positives = 96/272 (35%), Gaps = 49/272 (18%) Query: 730 DTESIPSPHTEAAKDTGQNG-----PKPPATLGADGPPPG---PPTPPPEDIPAPTEPTP 781 +TE PS EAA D+ ++G K G P PG PP P P+ P+P P Sbjct: 2518 ETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPPPLPQPDPRPSPPRPDV 2577 Query: 782 ASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA 841 P S S V EKE+ G+ + A L + ++ Sbjct: 2578 CM------ADPEGLSSESG--RVERLREKEKVQGRVGRRAPGKAKPASPARRLDLRGKRS 2629 Query: 842 EEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEG--------------GSGRAT 887 P K + A P + + +T AE+K+G G + Sbjct: 2630 PTPGKGP-ADRASRAPPRPR------STTSQVTPAEEKDGHSPMSKGLVNGLKAGPMALS 2682 Query: 888 TAKSSGAPQDSDSSAT---CSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPL 944 + SSGAP D + CS + D + R S +G+ AN P + + Sbjct: 2683 SKGSSGAPVYVDLAYIPNHCS------GKTADLDFFRRVRASYYVVSGNDPANGEPSRAV 2736 Query: 945 DLKQLKQRAAAIPPIQVTKVHEPPREDAAPTK 976 L+ +A +QVT + P D T+ Sbjct: 2737 LDALLEGKAQWGENLQVTLI---PTHDTEVTR 2765 Score = 33.5 bits (75), Expect = 2.7 Identities = 27/76 (35%), Positives = 37/76 (48%), Gaps = 12/76 (15%) Query: 805 VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE 864 V K K EE VEEG ++ A ELA + K E+ K E +E+ P K E Sbjct: 331 VSKLAKREEV-----VEEGAKE---ARSELAKELAKTEKKAK----ESSEKPPEKPAKPE 378 Query: 865 AAEATAEGALKAEKKE 880 + + ALKAEK++ Sbjct: 379 RVKTESSEALKAEKRK 394 >gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo sapiens] Length = 1560 Score = 83.2 bits (204), Expect = 3e-15 Identities = 135/550 (24%), Positives = 193/550 (35%), Gaps = 87/550 (15%) Query: 705 MEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPG 764 + A+ + + + + + S T+S P+P AA Q PP+ + P G Sbjct: 542 LSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPDG 601 Query: 765 ---PPTPP---------------PEDIPAPTEPTPASEATGAPTPPPAPPSP-SAPPPVV 805 P TP P+ PA + P P PP P+P +A PP Sbjct: 602 LVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQA 661 Query: 806 PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG----------------KAEEPVKSEC 849 + A++P E+ +PP+A A+ T AE P S Sbjct: 662 TTPQPSPGLASSP--EKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVP 719 Query: 850 TEEAEEGPAKGKDAEAAEATAEGA-LKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908 P +D A A+GA L + + + A + A + S Sbjct: 720 ASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSL 779 Query: 909 VDEAEGGDKNRLLSPRPSL--LTPTGDPRANASP--QKPLDLKQLKQRAAAIPPIQVTKV 964 +A GD L SP P+ P P++ + P + PL Q +P I V + Sbjct: 780 PHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQN 839 Query: 965 H---EPPREDAAPTKPAPPAPP-PPQNLQPESDAPQQP-----------GSSPRGKSRSP 1009 PP + APT P PP PP PQ+ PE P P SS SR P Sbjct: 840 QLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLP 899 Query: 1010 AP-PADKEAEKPVFFPAFAAEAQKLPGDPPCW----TSGLPFPVPPRE---VIKASPHAP 1061 AP P+D + + P + K P PP P P PPR V P P Sbjct: 900 APTPSDFQLQFPP-----SQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALP 954 Query: 1062 DPSAFSYAPPGHPLPLG--LHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQG 1119 P A H +P G L + A P T ++ PL S A + G Sbjct: 955 QPKAL--LERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPA---------ASVLVSG 1003 Query: 1120 MSVQLHVPYSEHAKAPVGPVTMGLP--LPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGV 1177 + HA AP GLP LP + K A S + ++ +GP + G+ Sbjct: 1004 QAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFA--SNLPTLNVAKAASSGPGKPSGL 1061 Query: 1178 PTAQEASVLR 1187 + S L+ Sbjct: 1062 QYESKLSGLK 1071 Score = 64.3 bits (155), Expect = 1e-09 Identities = 105/458 (22%), Positives = 161/458 (35%), Gaps = 74/458 (16%) Query: 684 KKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMV----EEAEATVNNSSDTESIPSPHT 739 ++ P A + +AA PP + + G++ + E++V A T + D+ + P Sbjct: 645 QQPPQAPTPQAAAPPQATTPQ-PSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQE 703 Query: 740 EAAKDTGQNGP--KPPATLGADGPPP----------------GPPTPPPEDIPAPTEPTP 781 + + GP PA++ PPP GP P + PAP P Sbjct: 704 RSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIP 763 Query: 782 ASEATGAPTPPPAPPSPSAPP----PVVPKEEKEEETAAAPPVEEGEEQKPPAAEEL-AV 836 A+ P P +P P P P +P + PP +PP+ L Sbjct: 764 AAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPH-PTRPPSRPPSRPQSVSRPPSEPPLHPC 822 Query: 837 DTGKAEEPVKSECTEEAEEG--PAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGA 894 +A + + + G P A A + L+ + + + Sbjct: 823 PPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQ---PPEGPLPPAPHL 879 Query: 895 PQDSDSSATCSADEVDEAEGGDKNRLLSPRPS----LLTPTGDPRANASPQKPLDLKQLK 950 P S SSA S+ E +RL +P PS P+ P + SP P L + Sbjct: 880 PPSSTSSAVASSSET-------SSRLPAPTPSDFQLQFPPSQGP--HKSPTPPPTLHLVP 930 Query: 951 QRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPR- 1003 + AA PP PPR T P P P P L+ P + G +P Sbjct: 931 EPAAPPPP--------PPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAA 982 Query: 1004 -------GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKA 1056 G SPA + P P + A P P +GLP P+ P E Sbjct: 983 PQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHA---PAPAPMAATGLP-PLLPAENKAF 1038 Query: 1057 SPHAPDPSAFSYAPPGHPLPLGL-HDTARPVLPRPPTI 1093 + + P + A G P GL +++ L +PPT+ Sbjct: 1039 ASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTL 1076 Score = 51.6 bits (122), Expect = 9e-06 Identities = 52/177 (29%), Positives = 66/177 (37%), Gaps = 29/177 (16%) Query: 742 AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAP---PSP 798 A D P PPATL PPP PP PPP PT T PP AP P Sbjct: 1326 ALDPVHQPPPPPATLKVAEPPPRPPPPPP--------PTGQMNGTVDHPPPAAPERKPLG 1377 Query: 799 SAPP-PVVPKEEKEEETAAAPPVEEG----------EEQKPPAAEELAVDTGKAEEPVKS 847 +AP P +P + E P EG P +E + V+ Sbjct: 1378 TAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVED 1437 Query: 848 ECTEEAEEGPAKGKDAEAAEAT------AEGALKAEKKEGGSGRATTAK-SSGAPQD 897 E + +GP A AA+ T A G A++++ S A SS +PQD Sbjct: 1438 ELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQD 1494 Score = 44.7 bits (104), Expect = 0.001 Identities = 78/329 (23%), Positives = 108/329 (32%), Gaps = 66/329 (20%) Query: 1705 SPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHS 1764 +P + A A P+ L+ P VL P TP + + + PQ S Sbjct: 650 APTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQ----ERS 705 Query: 1765 SSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQ 1824 PLS GP HL+ P S++ S P P T Sbjct: 706 QQPLSAEGP-HLSVPA-----------------------SVIVSAPPPAQDPA--PATPV 739 Query: 1825 SSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNT--GMKGIITAVE 1882 + G+ G G + AS + A Q +P PS+ H G + + Sbjct: 740 AKGA----GLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPH 795 Query: 1883 PSTPTVLRSTSTSSPVRPAATFPPATHCP---LGGTLDGVY----------------PTL 1923 P+ P + S RP + PP CP TL G++ PT Sbjct: 796 PTRPPSRPPSRPQSVSRPPSE-PPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTA 854 Query: 1924 -------MEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLV 1976 + P P E P P P + T A + S L PA +PS P Sbjct: 855 PGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRL-PAPTPSDFQLQFP-- 911 Query: 1977 PPVSGHATIARTPAKNLAPHHASPDPPAP 2005 P H + P +L P A+P PP P Sbjct: 912 PSQGPHKSPTPPPTLHLVPEPAAPPPPPP 940 Score = 42.7 bits (99), Expect = 0.004 Identities = 43/139 (30%), Positives = 58/139 (41%), Gaps = 20/139 (14%) Query: 881 GGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASP 940 GGS T A++S + S SS++ +A +D E G P PS P P Sbjct: 1254 GGSPSVTWARASSSLSSSSSSSS-AASSLDADEDG-------PMPSRNRP---PIKTYEA 1302 Query: 941 QKPLDLK-QLKQRAAAIPPIQVTK---VHEPPREDA----APTKPAPPAPPPPQNLQPES 992 + + LK ++KQ A + T VH+PP A A P PP PPPP Q Sbjct: 1303 RSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPP-PPPPPTGQMNG 1361 Query: 993 DAPQQPGSSPRGKSRSPAP 1011 P ++P K AP Sbjct: 1362 TVDHPPPAAPERKPLGTAP 1380 Score = 37.0 bits (84), Expect = 0.24 Identities = 86/371 (23%), Positives = 117/371 (31%), Gaps = 123/371 (33%) Query: 1881 VEPSTPTVLRSTSTSSPV---RPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVA 1937 V+P+TP +T ++PV +PA PPA PL L P +P P P+ A Sbjct: 603 VQPATPAA--ATGEAAPVLTVQPAPQAPPAVSTPLPLGLQ--QPQAQQPPQAP--TPQAA 656 Query: 1938 RPER---PRADTGHA------FLAKPPARSGLE--------------------------- 1961 P + P+ G A L +PP+ + Sbjct: 657 APPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHL 716 Query: 1962 --PAS----SPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHRE 2015 PAS +P +P P P G + P +P PAP A+ P Sbjct: 717 SVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASP------APAPQIPAAAP--- 767 Query: 2016 KTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2075 ++ P SSPSL H L D HL Sbjct: 768 ----------------------------LKGPGPSSSPSLPHQAPLG------DSPHLPS 793 Query: 2076 ELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVIT 2135 + P P RP S+P S P L P + + + + Sbjct: 794 PHPTRPPS----------RPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGI------FVI 837 Query: 2136 QDYTRHHPQQLSAPLPA--PLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGS----P 2189 Q+ QL P PA P + PG P L + P + LPP H P+ S Sbjct: 838 QN-------QLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVAS 890 Query: 2190 HSEGGKRSPEP 2200 SE R P P Sbjct: 891 SSETSSRLPAP 901 Score = 36.6 bits (83), Expect = 0.31 Identities = 102/462 (22%), Positives = 155/462 (33%), Gaps = 89/462 (19%) Query: 796 PSPSAPPPVVPKEEKEEETAAAPPV------EEGEEQKPPAAEELAVDTGKAEEPVKSEC 849 P P+ P P V + E++ +P G +Q ++ + E+ +++E Sbjct: 63 PEPNQPAPSVDLDFLEDDILGSPATGGGGGGSGGADQPCDILQQSLQEANITEQTLEAEA 122 Query: 850 ----------TEEAEEGPAKGKDAEAAEATAEG--ALKAEKKE----GGSGRATTAKSSG 893 T + +G A A A A A G AL + G T ++ Sbjct: 123 ELDLGPFQLPTLQPADGGAGPTGAGGAAAVAAGPQALFPGSTDLLGLQGPPTVLTHQALV 182 Query: 894 APQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLL-TPTGDPRANASPQKPLDLKQLKQR 952 PQD + A + G N L P P L P G P + Sbjct: 183 PPQDVVNKALSVQPFLQPV--GLGNVTLQPIPGLQGLPNGSPGGATA------------A 228 Query: 953 AAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQP------GSSPRG-- 1004 + PIQV V +P PT P + P +P G SP+G Sbjct: 229 TLGLAPIQV--VGQPVMALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAG 286 Query: 1005 ---KSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAP 1061 + A A VF A AA A P SG P V P + +SP P Sbjct: 287 LVIQKNLSAAVATTLNGNSVFGGAGAASA------PTGTPSGQPLAVAPG--LGSSPLVP 338 Query: 1062 DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP------PPLISSAKHPSVLERQIGA 1115 P+ LH T P+ P+P + P P + A ++ + GA Sbjct: 339 APNVI------------LHRTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQGEPGA 386 Query: 1116 ISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQA--GPPE 1173 + Q ++ + KA V G P P + KQ + G A PP Sbjct: 387 LPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQANV-----FKQPPATTTGAAPPQPPG 441 Query: 1174 SLGVPTA----QEASVLRGTALGSVPGGS--ITKGIPSTRVP 1209 +L P + + S + A +PG + + G P+ ++P Sbjct: 442 ALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLP 483 >gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sapiens] Length = 2715 Score = 82.8 bits (203), Expect = 4e-15 Identities = 118/497 (23%), Positives = 175/497 (35%), Gaps = 95/497 (19%) Query: 700 VEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGAD 759 ++DEE E EEE +E E + E +P+ E AK P PP T A Sbjct: 361 LDDEEEEKK----EEEEKDKEGEEKEERAVAEEMMPAAEKEEAKL-----PPPPLTPPAP 411 Query: 760 GPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819 PPP P PPP P P PPP PP P P P PP Sbjct: 412 SPPP--PLPPPSTSPPPPL-----------CPPPPPPVSPPPLPSPP----------PPP 448 Query: 820 VEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKK 879 +E +E+ PP + P+ P++ + EAA A EG Sbjct: 449 AQEEQEESPPPVVPATCSRKRGRPPLT----------PSQRAEREAARAGPEGTSPPTP- 497 Query: 880 EGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANAS 939 + + G P+DS + A S + ++S R S + T + Sbjct: 498 ------TPSTATGGPPEDSPTVAPKSTTFLKNIRQFIM-PVVSARSSRVIKTPRRFMDED 550 Query: 940 PQKPLDLK---QLKQRAAAIPPI--QVTKVHEPPREDAAPTKPAPPAPPPPQN------- 987 P KP ++ L+ PP+ + V PPR APT P+ P P P + Sbjct: 551 PPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPR---APTPPSTPVPLPEKRRSILREP 607 Query: 988 ----LQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSG 1043 + P P + P + SP P + +P+ A Q P + Sbjct: 608 TFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRA----PQFTPSEAHLKIYE 663 Query: 1044 LPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPR-PPTISNP------ 1096 PP +A P P+ S P P P + T LPR P ++ P Sbjct: 664 SVLTPPPLGAPEAPEPEPPPADDS---PAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVS 720 Query: 1097 ----PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKL 1152 P L + + + L + + A+ + Q P + P P M P++ ++ Sbjct: 721 PHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMP---PLEKARI 777 Query: 1153 A-----PFSGVKQEQLS 1164 A P SGV+++ S Sbjct: 778 AGVGSLPLSGVEEKMFS 794 Score = 47.4 bits (111), Expect = 2e-04 Identities = 94/376 (25%), Positives = 127/376 (33%), Gaps = 62/376 (16%) Query: 750 PKPPATLGADGPPPGPP---TPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVP 806 P+PP + A P P PPP + T TP S P P P+PP P P Sbjct: 1921 PRPPPSRWASPPLKTSPQLRVPPPTSVV--TALTPTSGELAPPGPAPSPPPPEDLGPDFE 1978 Query: 807 KEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAA 866 E +AA AA L + + EE V + + GP + E++ Sbjct: 1979 DMEVVSGLSAA--------DLDFAASLLGTEPFQ-EEIVAAGAMGSSHGGPGDSSEEESS 2029 Query: 867 EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 926 T+ G A +A + GAP+ D VD+ + + PR Sbjct: 2030 -PTSRYIHFPVTVVSAPGLAPSA-TPGAPRIE------QLDGVDDGTDSEAEAVQQPRGQ 2081 Query: 927 LLTPTGD--PRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPA-PPAPP 983 P+G RA + + + I + + P A P + + PPAPP Sbjct: 2082 GTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPP 2141 Query: 984 PPQNLQPESDAPQQPGSSPRG------------KSRSPAPPADKEAEKPVF--------F 1023 QP P R S PAP K A + F Sbjct: 2142 LANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVF 2201 Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTA 1083 A E + +P PP P+PP SP AP S+ P PL LG+ Sbjct: 2202 VKMAGEGEPVP--PPVKQP----PLPP----TISPTAPT----SWTLPPGPL-LGVLPVV 2246 Query: 1084 RPVLPRPPTISNPPPL 1099 V P PP PPPL Sbjct: 2247 GVVRPAPP--PPPPPL 2260 Score = 44.7 bits (104), Expect = 0.001 Identities = 46/161 (28%), Positives = 60/161 (37%), Gaps = 37/161 (22%) Query: 966 EPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025 +PP + AP P QNL P P +P S G + PAP + A V P Sbjct: 1819 DPPLDTDVLVPGAPERHSPIQNLDP----PLRPDS---GSAPPPAPRSFSGARIKV--PN 1869 Query: 1026 FAAEAQKL----------PGDPPCWTSGLP------FPVPPREVIKASPHAPDPSAFSYA 1069 ++ + L PG P T +P FP PPR + SP AP P +A Sbjct: 1870 YSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWA 1929 Query: 1070 ------------PPGHPLPLGLHDTARPVLPRPPTISNPPP 1098 PP + L T+ + P P S PPP Sbjct: 1930 SPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPP 1970 Score = 42.7 bits (99), Expect = 0.004 Identities = 83/341 (24%), Positives = 111/341 (32%), Gaps = 64/341 (18%) Query: 1883 PSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERP 1942 P P + S P+ P +T PP CP P + P LP P A+ E+ Sbjct: 402 PPPPLTPPAPSPPPPLPPPSTSPPPPLCP-------PPPPPVSPPPLPSPPPPPAQEEQE 454 Query: 1943 RADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002 + PP + PA+ K P PL P AR P SP Sbjct: 455 E--------SPPP----VVPATCSRKRGRP-PLTPSQRAEREAARA-----GPEGTSPPT 496 Query: 2003 PAPPASASDPHREKTQSKPFSIQELE-LRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGL 2061 P P + P + P S L+ +R + PV VS+ S K Sbjct: 497 PTPSTATGGPPEDSPTVAPKSTTFLKNIRQF-----------IMPV--VSARSSRVIKTP 543 Query: 2062 PKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQ 2121 + ++E + E+ P P+ P P P +P + P + Sbjct: 544 RRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQ----EPAPVPSPPRAPTPPSTPVPLPEK 599 Query: 2122 RVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRP---------PS 2172 R L + TR P AP P P S P A P RRP PS Sbjct: 600 RRSILREPTFR--WTSLTRELPPPPPAPPPPPAPSPPPA--PATSSRRPLLLRAPQFTPS 655 Query: 2173 DLY-------LPPPDHGAPARGSPHSEGGKRSP-EPNKTSV 2205 + + L PP GAP P SP EP +V Sbjct: 656 EAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAV 696 Score = 42.4 bits (98), Expect = 0.006 Identities = 68/250 (27%), Positives = 89/250 (35%), Gaps = 68/250 (27%) Query: 1911 PLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSG----LEPASSP 1966 PLGG G P+ P L P V P+ P PP RS L P P Sbjct: 1876 PLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPA----------PPRRSRRPSPLAPRPPP 1925 Query: 1967 SKGSEPRPL-------VPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQS 2019 S+ + P PL VPP + T + LAP +P PP PP + Sbjct: 1926 SRWASP-PLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPP-PPEDLGPDFEDMEVV 1983 Query: 2020 KPFSIQEL--------------ELRSLGYHGSSYSPEGVE--------------PVSPVS 2051 S +L E+ + G GSS+ G PV+ VS Sbjct: 1984 SGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVS 2043 Query: 2052 SPSL--THDKGLPKHLEELD------KSHLEGELRPK-------QPGPVKLGGEAAHLPH 2096 +P L + G P+ +E+LD S E +P+ PG V+ G A Sbjct: 2044 APGLAPSATPGAPR-IEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDR 2102 Query: 2097 LRPLPESQPS 2106 RP PE PS Sbjct: 2103 ARP-PEDLPS 2111 Score = 37.4 bits (85), Expect = 0.18 Identities = 75/352 (21%), Positives = 112/352 (31%), Gaps = 43/352 (12%) Query: 1842 PASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEP---STPTVLRSTSTSSPV 1898 PA P+ P T + RP + + + P S PT ST+T P Sbjct: 448 PAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPP 507 Query: 1899 RPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARS 1958 + T P + L + P + AR R + K P R Sbjct: 508 EDSPTVAPKSTTFLKNIRQFIMPVVS------------ARSSR---------VIKTPRRF 546 Query: 1959 GLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQ 2018 E P K L PP++ + + PA +P A PP+ P + R + Sbjct: 547 MDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPT-PPSTPVPLPEKRRSILR 605 Query: 2019 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2078 F L R L +P SP +P+ + + L + S ++ Sbjct: 606 EPTFRWTSL-TREL--PPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIY 662 Query: 2079 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDY 2138 P LG A P P +S P A G H + A ++ + + Sbjct: 663 ESVLTPPPLGAPEAPEPEPPPADDSPAEPEP---RAVGRTNHLSLPRFAPVVTTPVKAEV 719 Query: 2139 TRHHPQQLS------APLPAPLYSFPGASCPVL------DLRRPPSDLYLPP 2178 + H LS A L PL + P L+ PPS +PP Sbjct: 720 SPHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPP 771 Score = 37.0 bits (84), Expect = 0.24 Identities = 85/401 (21%), Positives = 127/401 (31%), Gaps = 82/401 (20%) Query: 1735 VPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRE 1794 +PP P TP A P P P S PL P P ++ P S ++E Sbjct: 401 LPPPPLTPP------APSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQE 454 Query: 1795 RDR--------DREREKSILTSTTTVEH--APIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844 R+R + LT + E A GT + + ++ GG S + Sbjct: 455 ESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVA 514 Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTV-----LRSTSTSSPV- 1898 I + R S + T + + P P V LR T+SP Sbjct: 515 PKSTTFLKNIRQFIMPVVSARSSRVIKTPRR-FMDEDPPKPPKVEVSPVLRPPITTSPPV 573 Query: 1899 ---------RPAATFPPATHCPLGGTLDGVY--PT---------LMEPVLLPKEAPRVAR 1938 P A PP+T PL + PT L P P P + Sbjct: 574 PQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSP 633 Query: 1939 PERPRADTGHAFLAKPP----------------------ARSGLEPASSPSKGS--EPRP 1974 P P + L + P A EP P+ S EP P Sbjct: 634 PPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEP 693 Query: 1975 LVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGY 2034 + H ++ R P A P PA ++ P + +P +Q L+ + L Sbjct: 694 RAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQP--LQALQTQLL-- 749 Query: 2035 HGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2075 P+ + P P P + P+ + L+K+ + G Sbjct: 750 ------PQALPPPQPQLQPPPS-----PQQMPPLEKARIAG 779 Score = 33.9 bits (76), Expect = 2.0 Identities = 13/34 (38%), Positives = 25/34 (73%) Query: 506 QQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVE 539 ++Q+Q + +E+K+E+EK+KE E++EE+ E Sbjct: 355 KKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAE 388 Score = 32.7 bits (73), Expect = 4.5 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 2/60 (3%) Query: 488 RRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEK--EKEKEAEKEEEKPEVENDKEDL 545 RR G Q ++Q+Q+ + + +EEKD++ EKE+ A EE P E ++ L Sbjct: 342 RRVGSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKL 401 Score = 32.3 bits (72), Expect = 5.9 Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 10/115 (8%) Query: 105 SKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPH-TDPELELV 163 +++ +L P PL P+P P S T P+ PP PP + P L Sbjct: 394 AEKEEAKLPPPPLTPPAPSPPPPLPPPS---------TSPPPPLCPPPPPPVSPPPLPSP 444 Query: 164 PPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPP 218 PP ++EE ++ V ++ L Q+ E A PE P +P P Sbjct: 445 PPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTP 499 >gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 855 Score = 81.3 bits (199), Expect = 1e-14 Identities = 134/528 (25%), Positives = 169/528 (32%), Gaps = 129/528 (24%) Query: 762 PPGPPTPPPEDIPAPTE---------PTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEE 812 PPG P PPP PA P +E G P S P Sbjct: 29 PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88 Query: 813 ETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTE------------EAEEGPAKG 860 A+ PP E+ PPA G P ++ T AEE A+G Sbjct: 89 NPASRPPASGRGERAPPAKN---TSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 145 Query: 861 KDAEAAEATAEGA---------------------LKAEKKEGGSGRATTAKSSGAPQDSD 899 K EA + +A A +A E G R + P + Sbjct: 146 KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 205 Query: 900 SSATCSADEVDEAE-----------GGDKNR------------LLSPRPSLLTPTGDPRA 936 + SA E E GG R L SP S + G PRA Sbjct: 206 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 265 Query: 937 NASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAP----------TKPAPPA----- 981 A P +P + A+ P QVT PPR+DAAP P+P A Sbjct: 266 PAHPSQP-----KPKGLQALRPPQVT----PPRKDAAPALGPLSSSPLATPSPSAALQSQ 316 Query: 982 PPPPQNLQPESD------------APQQPGSSPRGKSRSPAPPA--DKEAEKPVFFPAFA 1027 PP P S AP P S+P P+PPA +A + P Sbjct: 317 APPTLPATPHSSSLTCQLATPLPLAPPSP-SAPPSLQTLPSPPATPPSQATTSLGSPTLQ 375 Query: 1028 AEAQKLPGDPPCWTSGLPFP-------VPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH 1080 A LP PP P P +PP + + P +P S + P P L +H Sbjct: 376 ATHSFLP-SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 434 Query: 1081 DTARPVLPRP-PTISNP------PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAK 1133 P P P P + P PP+ SA PS + A L VP S A Sbjct: 435 LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA------PPLQVPPSPPAS 488 Query: 1134 APVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPP-ESLGVPTA 1180 P+ P P P P K +P A PP ++L P A Sbjct: 489 PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPA 536 Score = 73.9 bits (180), Expect = 2e-12 Identities = 129/543 (23%), Positives = 168/543 (30%), Gaps = 76/543 (13%) Query: 683 KKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAA 742 K +P S + G+ + EE V +AT S + + Sbjct: 107 KNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSG 166 Query: 743 KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPP 802 G P A G G P P P P P P + A PSP+ Sbjct: 167 PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPA--- 223 Query: 803 PVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGP-AKG- 860 A P G Q+ PA+ L+ P +S GP A+G Sbjct: 224 ------------ARRRPSAGGGLQR-PASRSLSSSATPLSSPARS--------GPSARGT 262 Query: 861 --KDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKN 918 A ++ +G + R A + G P S AT S +++ Sbjct: 263 PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLATPSPSAALQSQ-APPT 320 Query: 919 RLLSPRPSLLT---PTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEP-------- 967 +P S LT T P A SP P L+ L A P T + P Sbjct: 321 LPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSF 380 Query: 968 -PREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAF 1026 P +P PP PP L P P P S P +P+P A A Sbjct: 381 LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPN---------AL 431 Query: 1027 AAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPV 1086 A + P PP P PP + SP A P + S PP P A P Sbjct: 432 AVHLLQAPFSPP--------PSPPVQA-PFSPPASPPVSPSATPPSQAPP----SLAAPP 478 Query: 1087 LPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLP 1146 L PP+ PP+ SA P + A +QL P + A P LP P Sbjct: 479 LQVPPSPPASPPMSPSATPPPQAPPPLAA----PPLQLAKPPPQAPPALATPPLQALPSP 534 Query: 1147 MDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPST 1206 P S Q SP P L P Q VL L P + + + Sbjct: 535 -------PASFPGQAPFSPSASL-PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP 586 Query: 1207 RVP 1209 R P Sbjct: 587 RRP 589 Score = 63.9 bits (154), Expect = 2e-09 Identities = 103/443 (23%), Positives = 156/443 (35%), Gaps = 59/443 (13%) Query: 681 RKKKKAPAAASE------EAAFPPVVEDEEMEASGVSG--NEEEMVEEAEATVNNSSDTE 732 R +APA S+ +A PP V +A+ G + + + + S Sbjct: 260 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP 319 Query: 733 SIPSPHTEAAKDTGQNGPKPPATLGADGPP-----PGPP-TPPPEDIPAPTEPTPASEAT 786 ++P+ ++ P P A PP P PP TPP + + PT + + Sbjct: 320 TLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHS 379 Query: 787 GAPTPPPAP---PSPSAPPPV-VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA- 841 P+PP +P P P APP + +P + A+PP+ P A LAV +A Sbjct: 380 FLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP 439 Query: 842 -----EEPVKSECTEEAEE--GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGA 894 PV++ + A P+ ++A + A L+ S A+ S A Sbjct: 440 FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP----SPPASPPMSPSA 495 Query: 895 PQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP-----RANASPQKPLDLKQL 949 + +A + A+ + P L P +A SP L + L Sbjct: 496 TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 555 Query: 950 KQRAAAIPPIQVTKVHE-PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR---GK 1005 PP+ + + PP A+PT AP PP P P S PR Sbjct: 556 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP--------GPDTSVSGPRLTLAL 607 Query: 1006 SRSPAPPADKEAEKPVFFPAFA---AEAQKLPGDPPCWTSG-----LPFPVPPREVIKAS 1057 + P PP + + P A + A P + + SG P P E+ Sbjct: 608 APGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH 667 Query: 1058 PHA----PDPSAFSYAPPGHPLP 1076 P A P P PG PLP Sbjct: 668 PAAWSRGPAPPLAFRGAPGAPLP 690 Score = 57.8 bits (138), Expect = 1e-07 Identities = 136/579 (23%), Positives = 190/579 (32%), Gaps = 131/579 (22%) Query: 1737 PTPGTPATAMDRLAYLPTA----PQPFSSRHSSSPLSPGGP----THLTKPTTTSSSERE 1788 PTPGTP+ AM R + P+P S P GP + ++ +TT S Sbjct: 167 PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE--GPRKSVSSASEHSTTEPSPAA 224 Query: 1789 RDRDR-----ERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1843 R R +R R S ++ P R GT ++ G + RP Sbjct: 225 RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSAR-GTPRAPAHPSQPKPKGLQALRPP 283 Query: 1844 SHSHAHQHS-----PIS------PRTQDALQ-QRPSVLHNTGMKGIITAVEPSTPTVLRS 1891 + + + P+S P ALQ Q P L T +T + +TP L Sbjct: 284 QVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTC-QLATPLPLAP 342 Query: 1892 TSTSSPVR------PAATFPPATHCPLGG-TLDGVYPTLMEPVLLPKEAPRVARPERPRA 1944 S S+P P AT P LG TL + L P L P P P+ P A Sbjct: 343 PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP---PQAPPA 399 Query: 1945 DTGHAFLA--KPPARSGLEPASSPSKGSE--------------------PRPLVPPVSGH 1982 A PPA L P ++PS + P PP S Sbjct: 400 LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 459 Query: 1983 ATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS------------------- 2023 + + TP P A+P PP+ + P + + P Sbjct: 460 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 519 Query: 2024 --------IQELELRSLGYHGSS-YSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKS--- 2071 +Q L + G + +SP P+SP+++P L L ++ S Sbjct: 520 PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA 579 Query: 2072 --HLEGELRPKQPGP-VKLGGEAAHLPHLRPLPESQPSSSP-LLQTAPGVKGHQRVVTLA 2127 L+ RP PGP + G L L P P PS SP + P + GH T Sbjct: 580 SPTLQAPRRPPTPGPDTSVSGPRLTLA-LAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 638 Query: 2128 QH--------------ISEVITQDYTRHHPQQLS--------------APLPAPLYSFPG 2159 S + HP S APLP P + PG Sbjct: 639 PEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 698 Query: 2160 AS---CPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGK 2195 ++ C + + P S P P SP + GGK Sbjct: 699 SADGLCTIYETEGPESATPAPGALDPGP---SPGTSGGK 734 Score = 35.0 bits (79), Expect = 0.91 Identities = 76/317 (23%), Positives = 99/317 (31%), Gaps = 80/317 (25%) Query: 2158 PGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVS 2217 P A P L RPP PPP A R + R P + +GG + Sbjct: 17 PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG-------AT 69 Query: 2218 PPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSK 2277 PE G +RSA G+ S S+PPA S E + Sbjct: 70 IPESAPRAGPTRSA-----------------GTSSRNPASRPPA--SGRGERAPPAKNTS 110 Query: 2278 KQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAII 2337 ++ P + Q G I + +E + EA Sbjct: 111 PGPVSSPGRASGTTRPG-PLGQKGLRI-----------------SAEETVARGKATEAPK 152 Query: 2338 RKALMGGGGK---AKVSGRPSSRKAKS----------PAPGLASGDRPP------SVSSV 2378 R AL G + G PS A+ P P ++ RPP SVSS Sbjct: 153 RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSA 212 Query: 2379 HSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLA- 2437 SE +P R RPS+ G P + +S P PA SGP A Sbjct: 213 -SEHSTTEPSPAARR----RPSAGGGLQRP-------ASRSLSSSATPLSSPARSGPSAR 260 Query: 2438 ----GPHHAWDEEPKPL 2450 P H +PK L Sbjct: 261 GTPRAPAHPSQPKPKGL 277 Score = 34.7 bits (78), Expect = 1.2 Identities = 61/275 (22%), Positives = 89/275 (32%), Gaps = 36/275 (13%) Query: 1929 LPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART 1988 +P+ APR A P R + ++PPA SG + P+K + P P+ P T Sbjct: 70 IPESAPR-AGPTRSAGTSSRNPASRPPA-SGRGERAPPAKNTSPGPVSSPGRASGTTRPG 127 Query: 1989 PAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVS 2048 P ++ + A + P R + G+ G P + Sbjct: 128 PLGQKGLRISAEETVARGKATEAPKRSALSA----------------GARRDTSGPTPGT 171 Query: 2049 PVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPES--QPS 2106 P SP++ L + RP GP K A+ P P + +PS Sbjct: 172 P--SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPS 229 Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166 + LQ L+ + T P S P P L + Sbjct: 230 AGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL--------- 280 Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPN 2201 RPP PP APA G P S +P P+ Sbjct: 281 --RPPQ--VTPPRKDAAPALG-PLSSSPLATPSPS 310 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.309 0.128 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 127,399,661 Number of Sequences: 37866 Number of extensions: 8468199 Number of successful extensions: 165420 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 1384 Number of HSP's successfully gapped in prelim test: 2865 Number of HSP's that attempted gapping in prelim test: 47685 Number of HSP's gapped (non-prelim): 62207 length of query: 2462 length of database: 18,247,518 effective HSP length: 119 effective length of query: 2343 effective length of database: 13,741,464 effective search space: 32196250152 effective search space used: 32196250152 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.