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Search of human proteins with 239582714
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239582714 leucine rich repeat containing 17 isoform 2 [Homo
sapiens]
(313 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239582714 leucine rich repeat containing 17 isoform 2 [Homo s... 642 0.0
gi|72534676 leucine rich repeat containing 17 isoform 1 [Homo sa... 635 0.0
gi|11321571 slit homolog 3 [Homo sapiens] 97 2e-20
gi|188528675 slit homolog 1 [Homo sapiens] 96 5e-20
gi|4759146 slit homolog 2 [Homo sapiens] 93 3e-19
gi|40217820 slit and trk like 3 protein [Homo sapiens] 74 2e-13
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens] 74 2e-13
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 73 3e-13
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 72 5e-13
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 70 3e-12
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 69 5e-12
gi|40217817 slit and trk like 1 protein [Homo sapiens] 67 2e-11
gi|4507531 toll-like receptor 3 [Homo sapiens] 67 2e-11
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 67 3e-11
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 67 3e-11
gi|27436867 slit and trk like 4 protein [Homo sapiens] 64 1e-10
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 64 2e-10
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 64 2e-10
gi|109150416 peroxidasin [Homo sapiens] 64 2e-10
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens] 63 3e-10
gi|40217825 slit and trk like 6 [Homo sapiens] 63 4e-10
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 62 5e-10
gi|12597641 leucine rich repeat containing 19 [Homo sapiens] 61 1e-09
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 61 1e-09
gi|194272183 G protein-coupled receptor 124 [Homo sapiens] 60 2e-09
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 60 2e-09
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 60 2e-09
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 60 3e-09
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 59 4e-09
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 59 4e-09
>gi|239582714 leucine rich repeat containing 17 isoform 2 [Homo
sapiens]
Length = 313
Score = 642 bits (1655), Expect = 0.0
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 1 MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL 60
MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL
Sbjct: 1 MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL 60
Query: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI
Sbjct: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
Query: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180
ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI
Sbjct: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180
Query: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST
Sbjct: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
Query: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS 300
FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS
Sbjct: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS 300
Query: 301 SNGIEFIDPGSLR 313
SNGIEFIDPGSLR
Sbjct: 301 SNGIEFIDPGSLR 313
>gi|72534676 leucine rich repeat containing 17 isoform 1 [Homo
sapiens]
Length = 441
Score = 635 bits (1637), Expect = 0.0
Identities = 309/311 (99%), Positives = 310/311 (99%)
Query: 1 MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL 60
MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL
Sbjct: 1 MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL 60
Query: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI
Sbjct: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
Query: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180
ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI
Sbjct: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180
Query: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST
Sbjct: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
Query: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS 300
FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS
Sbjct: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS 300
Query: 301 SNGIEFIDPGS 311
SNGIEFIDP +
Sbjct: 301 SNGIEFIDPAA 311
Score = 69.3 bits (168), Expect = 4e-12
Identities = 46/135 (34%), Positives = 66/135 (48%), Gaps = 1/135 (0%)
Query: 65 LDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEA 124
LDC+ ++L V P D++ + L+ NKI L+ F +LK L+L N I I+ A
Sbjct: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAA 311
Query: 125 FFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNR 184
F GL L L L +N ++ V L L L DNPW C I L L+ N
Sbjct: 312 FLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNV 371
Query: 185 NLGNYAKCESPQEQK 199
+ N +C++P+E K
Sbjct: 372 HF-NGLECKTPEEYK 385
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 96.7 bits (239), Expect = 2e-20
Identities = 80/322 (24%), Positives = 145/322 (45%), Gaps = 65/322 (20%)
Query: 42 SNPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMF 101
S P A + C +DC+ + L+ + P+ ++ + L +N I+ + F
Sbjct: 268 SEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAF 327
Query: 102 SKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF------------ 149
+++KKLK +D+ +N+IS I +AF GL LT+L+L N+I + + +F
Sbjct: 328 TQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLN 387
Query: 150 ----------------------------------IYTPLLSY--LRLYDNPWHCTCEIET 173
++ PL S L L NP+ C C ++
Sbjct: 388 ANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKW 447
Query: 174 LISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQL-CNEEEKEQLDPKPQVSGR--P 230
L LQ G A+C SP+ NK++ QIKS++ C+ E D + + S
Sbjct: 448 LADYLQDNPIETSG--ARCSSPRRLANKRISQIKSKKFRCSGSE----DYRSRFSSECFM 501
Query: 231 PVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKE-FE 289
++ PE C + +DC ++L ++P+++P + L L+ N+++ L F+
Sbjct: 502 DLVCPE--KCRCEGTI-----VDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFK 554
Query: 290 DVHELKKLNLSSNGIEFIDPGS 311
+ L+K+NLS+N I+ + G+
Sbjct: 555 KLPNLRKINLSNNKIKEVREGA 576
Score = 88.6 bits (218), Expect = 7e-18
Identities = 64/235 (27%), Positives = 106/235 (45%), Gaps = 21/235 (8%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L+ N+I+ + F +K+L L N IS IE AF L L L L +N I
Sbjct: 135 LTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNIS 194
Query: 143 VLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKK 202
+ F + P + LRL+ N +C C + L L+ + R +G + C +P
Sbjct: 195 RILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLR--QRRTVGQFTLCMAPV------ 246
Query: 203 LRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDS----TFCHNYVFPIQTLDCKRKE 258
++ + + ++KE + P P PP S C N + +DC+ K
Sbjct: 247 --HLRGFNVADVQKKEYVCPAPH--SEPPSCNANSISCPSPCTCSNNI-----VDCRGKG 297
Query: 259 LKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGSLR 313
L ++P N+P IV++ L N I + F +LK++++S N I I P + +
Sbjct: 298 LMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQ 352
Score = 77.8 bits (190), Expect = 1e-14
Identities = 56/226 (24%), Positives = 101/226 (44%), Gaps = 25/226 (11%)
Query: 86 MLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLT 145
++L N++ T+ +F LK+L L+ N I + ++ F GL+ + L L N+I +T
Sbjct: 586 LMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTIT 645
Query: 146 EEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQ 205
F LS + L NP++C C + L L+ + R + +C+ P K ++
Sbjct: 646 PGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLR--KRRIVSGNPRCQKPFFLKEIPIQD 703
Query: 206 IKSEQLC---NEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQT-LDCKRKELKK 261
+ + NEE QL P+ C ++T + C K L+
Sbjct: 704 VAIQDFTCDGNEESSCQLSPR------------------CPEQCTCMETVVRCSNKGLRA 745
Query: 262 VPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFI 307
+P +P D+ +L L N + + P+E + L ++LS+N I +
Sbjct: 746 LPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTLIDLSNNSISML 790
Score = 59.7 bits (143), Expect = 3e-09
Identities = 53/166 (31%), Positives = 71/166 (42%), Gaps = 9/166 (5%)
Query: 40 RGSNPVKRYAP-GLPCDVYT-YLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLK 97
R SN R P G+P DV YL +L R+L + + L + L+ N I L
Sbjct: 737 RCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSAL-----RHLTLIDLSNNSISMLT 791
Query: 98 NNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSY 157
N FS L +L L N + I AF GL L L L N I + E F LS+
Sbjct: 792 NYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSH 851
Query: 158 LRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKL 203
L L NP HC C + L ++ A+C SP+ ++ L
Sbjct: 852 LALGTNPLHCDCSLRWLSEWVKAGYKE--PGIARCSSPEPMADRLL 895
Score = 40.8 bits (94), Expect = 0.002
Identities = 19/63 (30%), Positives = 34/63 (53%)
Query: 251 TLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPG 310
++DC L+ VP IP + +LDL N I ++ +F + L+ L+L N + I+ G
Sbjct: 44 SVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERG 103
Query: 311 SLR 313
+ +
Sbjct: 104 AFQ 106
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 95.5 bits (236), Expect = 5e-20
Identities = 85/327 (25%), Positives = 139/327 (42%), Gaps = 56/327 (17%)
Query: 35 AGGGRRGSNPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIR 94
+G G G P + G C +DC+ + L + P+ + + L N I+
Sbjct: 264 SGQGEAGRVPTCTLSSG-SCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIK 322
Query: 95 TLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF--IYT 152
++ FS ++KL+ +DL N+I++I +AF GL L +L+L N+I L VF +YT
Sbjct: 323 SIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYT 382
Query: 153 ----------------------PLLSYLRLYDN------------------------PWH 166
LS L LYDN P+
Sbjct: 383 LQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFI 442
Query: 167 CTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQL-CNEEEKEQLDPKPQ 225
C C ++ L L+ G A+C SP+ NK++ QIKS++ C+ +E+ + P
Sbjct: 443 CDCNLKWLADFLRTNPIETSG--ARCASPRRLANKRIGQIKSKKFRCSAKEQYFI---PG 497
Query: 226 VSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRP 285
+ D H ++C +L K+P IP +L L+ N+I+ L
Sbjct: 498 TEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEA 557
Query: 286 K-EFEDVHELKKLNLSSNGIEFIDPGS 311
F+ + LKK+NLS+N + I+ G+
Sbjct: 558 TGMFKKLTHLKKINLSNNKVSEIEDGA 584
Score = 88.6 bits (218), Expect = 7e-18
Identities = 65/235 (27%), Positives = 108/235 (45%), Gaps = 15/235 (6%)
Query: 81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQ 140
Q L + L+ N I+ + F LK+L L +N+IS IE AF L L L L +N
Sbjct: 133 QALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNN 192
Query: 141 IKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKN 200
I + F + P L RL+ N C C + L L+ + +G + +C P +
Sbjct: 193 ITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLR--QRPTIGLFTQCSGPASLRG 250
Query: 201 KKLRQI-KSEQLCN-EEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKE 258
+ ++ KSE C+ + E ++ SG P + C N + +DC+ K
Sbjct: 251 LNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAM------CTCSNGI-----VDCRGKG 299
Query: 259 LKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGSLR 313
L +P N+P + ++ L N I + P F +L++++LS+N I I P + +
Sbjct: 300 LTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQ 354
Score = 77.0 bits (188), Expect = 2e-14
Identities = 63/247 (25%), Positives = 108/247 (43%), Gaps = 42/247 (17%)
Query: 88 LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEE 147
L N++ ++++ MF L++L L+ N IS I +++F GL + L L NQI ++
Sbjct: 596 LTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPG 655
Query: 148 VFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIK 207
F LS L L NP++C C++ L L+ + + + +C++P + L+ +
Sbjct: 656 AFDTLQSLSTLNLLANPFNCNCQLAWLGGWLR--KRKIVTGNPRCQNPDFLRQIPLQDVA 713
Query: 208 SEQLCNEEEKEQ--LDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNN 265
EE +E+ P+PQ C + V + C K L+ +P
Sbjct: 714 FPDFRCEEGQEEGGCLPRPQCP----------QECACLDTV-----VRCSNKHLRALPKG 758
Query: 266 IPPDIVKL-----------------------DLSYNKINQLRPKEFEDVHELKKLNLSSN 302
IP ++ +L DLS NKI+ L F ++ +L L LS N
Sbjct: 759 IPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYN 818
Query: 303 GIEFIDP 309
++ I P
Sbjct: 819 ALQCIPP 825
Score = 65.5 bits (158), Expect = 6e-11
Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 8/160 (5%)
Query: 47 RYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLL---ARNKIRTLKNNMFSK 103
++ LP + + E YLD + LV PG ++ L + NKI +L N+ F+
Sbjct: 750 KHLRALPKGIPKNVTELYLDGNQFTLV---PGQLSTFKYLQLVDLSNNKISSLSNSSFTN 806
Query: 104 FKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
+L +L L N + I AF GL L L L N I L E +F LS+L + N
Sbjct: 807 MSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
Query: 164 PWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKL 203
P +C C + L S ++ A+C PQ+ + K L
Sbjct: 867 PLYCDCHLRWLSSWVKTGYKE--PGIARCAGPQDMEGKLL 904
Score = 49.7 bits (117), Expect = 3e-06
Identities = 31/99 (31%), Positives = 49/99 (49%)
Query: 65 LDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEA 124
+DC L + P++ + L N I + N F+ K+L+ L L +N+I +E A
Sbjct: 45 VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGA 104
Query: 125 FFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
F + +L L L NQ+ +L E +F LS L L +N
Sbjct: 105 FDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSEN 143
Score = 42.0 bits (97), Expect = 7e-04
Identities = 19/61 (31%), Positives = 35/61 (57%)
Query: 251 TLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPG 310
T+DC L+ +P NIP + +L+L+ N I ++ +F + +L+ L L N I ++ G
Sbjct: 44 TVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERG 103
Query: 311 S 311
+
Sbjct: 104 A 104
Score = 34.7 bits (78), Expect = 0.11
Identities = 22/67 (32%), Positives = 30/67 (44%)
Query: 105 KKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNP 164
+ + L+L N I++I F GL +L L L NQI + F L LRL N
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 165 WHCTCEI 171
H E+
Sbjct: 121 LHMLPEL 127
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 92.8 bits (229), Expect = 3e-19
Identities = 80/314 (25%), Positives = 137/314 (43%), Gaps = 61/314 (19%)
Query: 52 LPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLD 111
L C +DC+ + L + P+ + + L +N I+ + FS +KKL+ +D
Sbjct: 271 LHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRID 330
Query: 112 LQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF---------------------- 149
L N+IS++ +AF GL L +L+L N+I L + +F
Sbjct: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390
Query: 150 IYTPL--LSYLRLYD------------------------NPWHCTCEIETLISMLQIPRN 183
+ L L+ L LYD NP+ C C ++ L L
Sbjct: 391 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPI 450
Query: 184 RNLGNYAKCESPQEQKNKKLRQIKSEQL-CNEEEKEQL----DPKPQVSGRPPVIKPEVD 238
G A+C SP+ NK++ QIKS++ C+ +E+ + D + ++SG +
Sbjct: 451 ETSG--ARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPE 508
Query: 239 STFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKE-FEDVHELKKL 297
C T+DC ++L K+P +IP +L L+ N+ L F+ + +L+K+
Sbjct: 509 KCRCEG-----TTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563
Query: 298 NLSSNGIEFIDPGS 311
N S+N I I+ G+
Sbjct: 564 NFSNNKITDIEEGA 577
Score = 91.3 bits (225), Expect = 1e-18
Identities = 63/232 (27%), Positives = 106/232 (45%), Gaps = 16/232 (6%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L+ N+I+ + F +K+L L N+IS IE AF L L L L +N I
Sbjct: 129 LYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIT 188
Query: 143 VLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISML-QIPRNRNLGNYAKCESPQEQKNK 201
L+ F + P L RL+ N +C C + L L Q PR +G Y +C P +
Sbjct: 189 RLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPR---VGLYTQCMGPSHLRGH 245
Query: 202 KLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKK 261
+ +++ + + + P V P + C N + +DC+ K L +
Sbjct: 246 NVAEVQKREFVCSGHQSFMAPSCSVLHCPA-------ACTCSNNI-----VDCRGKGLTE 293
Query: 262 VPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGSLR 313
+P N+P I ++ L N I + P F +L++++LS+N I + P + +
Sbjct: 294 IPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQ 345
Score = 77.8 bits (190), Expect = 1e-14
Identities = 58/219 (26%), Positives = 101/219 (46%), Gaps = 16/219 (7%)
Query: 86 MLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLT 145
+LL N++ +++ MF + LK+L L+ N I+ + +++F GL+ + L L NQI +
Sbjct: 587 ILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVA 646
Query: 146 EEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQ 205
F LS L L NP++C C + L L+ + R + +C+ P K ++
Sbjct: 647 PGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLR--KKRIVTGNPRCQKPYFLKEIPIQD 704
Query: 206 IKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNN 265
+ + ++ + P R P +D+ + C K LK +P
Sbjct: 705 VAIQDFTCDDGNDDNSCSP--LSRCPTECTCLDT-----------VVRCSNKGLKVLPKG 751
Query: 266 IPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGI 304
IP D+ +L L N+ L PKE + L ++LS+N I
Sbjct: 752 IPRDVTELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRI 789
Score = 62.0 bits (149), Expect = 7e-10
Identities = 54/172 (31%), Positives = 76/172 (44%), Gaps = 7/172 (4%)
Query: 40 RGSNPVKRYAP-GLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKN 98
R SN + P G+P DV E YLD + LV + L + L+ N+I TL N
Sbjct: 739 RCSNKGLKVLPKGIPRDVT----ELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSN 794
Query: 99 NMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYL 158
FS +L +L L N + I F GL L L L N I V+ E F LS+L
Sbjct: 795 QSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHL 854
Query: 159 RLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQ 210
+ NP +C C ++ L ++ A+C P E +K L S++
Sbjct: 855 AIGANPLYCDCNMQWLSDWVKSEYKE--PGIARCAGPGEMADKLLLTTPSKK 904
Score = 45.1 bits (105), Expect = 8e-05
Identities = 22/63 (34%), Positives = 35/63 (55%)
Query: 251 TLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPG 310
T+DC L+ VP NIP + +LDL+ N I ++ +F + L+ L L N I I+ G
Sbjct: 38 TVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERG 97
Query: 311 SLR 313
+ +
Sbjct: 98 AFQ 100
Score = 31.6 bits (70), Expect = 0.95
Identities = 20/59 (33%), Positives = 26/59 (44%)
Query: 105 KKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
+ + LDL N I++I F GL L L L N+I + F L LRL N
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRN 113
>gi|40217820 slit and trk like 3 protein [Homo sapiens]
Length = 977
Score = 73.6 bits (179), Expect = 2e-13
Identities = 61/214 (28%), Positives = 92/214 (42%), Gaps = 30/214 (14%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L NK+ +N+ F + L+ L N I +IES AF L+KL L+L N I
Sbjct: 127 LKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIP 186
Query: 143 VLTEEVF------------------IYTPLLSY-------LRLYDNPWHCTCEIETLISM 177
+L +F Y +L + L+L +NPW+CTCEI L S
Sbjct: 187 MLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSW 246
Query: 178 LQ-IPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC---NEEEKEQLDPKPQVSGRPPVI 233
L+ IP +G+ CE+P K LR+I+ +LC ++ E E P S
Sbjct: 247 LERIPYTALVGDIT-CETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENA 305
Query: 234 KPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIP 267
P S+ + F +++ K + P P
Sbjct: 306 WPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQP 339
Score = 53.5 bits (127), Expect = 2e-07
Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 18/143 (12%)
Query: 81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQ 140
Q L ++ N IR ++ FS LK L L N + + ++AF G + L L L+ N
Sbjct: 480 QSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTS-LARLNLRKNY 538
Query: 141 IKVLTEEVFIYTPLLSYLR---------LYDNPWHCTCEIETLISMLQIPRNRNLGNYAK 191
F+Y P+ L L +NPW CTC++ ++ + ++
Sbjct: 539 --------FLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVL 590
Query: 192 CESPQEQKNKKLRQIKSEQLCNE 214
C SP+ ++ +R I+ E LC E
Sbjct: 591 CRSPENLTHRDVRTIELEVLCPE 613
Score = 43.1 bits (100), Expect = 3e-04
Identities = 24/74 (32%), Positives = 36/74 (48%)
Query: 86 MLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLT 145
+ L RN +R L N F S++L N + I++ AF GL L L L N++ V
Sbjct: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
Query: 146 EEVFIYTPLLSYLR 159
+ F+ L YL+
Sbjct: 142 NDTFLGLESLEYLQ 155
Score = 28.5 bits (62), Expect = 8.0
Identities = 15/41 (36%), Positives = 23/41 (56%)
Query: 273 LDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGSLR 313
L L N+I+ ++ F ++ LK L L+ N IE + PG R
Sbjct: 437 LHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFR 477
>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
Length = 441
Score = 73.6 bits (179), Expect = 2e-13
Identities = 52/166 (31%), Positives = 78/166 (46%), Gaps = 6/166 (3%)
Query: 52 LPCDVYTYLHE-KYLDCQERKLVYVLPGWPQDLL---HMLLARNKIRTLKNNMFSKFKKL 107
LP V+ LH +YL Q+ + Y+ DL+ H+ L NK+ +L F L
Sbjct: 140 LPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNL 199
Query: 108 KSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHC 167
L L +N++ + +AF L +LTTL L +N + L E L +LRL NPW C
Sbjct: 200 DRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDC 259
Query: 168 TCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCN 213
C +L LQ R R + C SP + + L+ +++E N
Sbjct: 260 GCRARSLWEWLQ--RFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRN 303
Score = 43.9 bits (102), Expect = 2e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 4/96 (4%)
Query: 72 LVYVLPGWPQDLLHM----LLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFG 127
+ Y+ P + +H+ L ++RTL F KL +L L + +S + + F G
Sbjct: 88 ITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGG 147
Query: 128 LNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
L+ L L LQ N I+ L +++F+ LS+L L+ N
Sbjct: 148 LHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGN 183
Score = 38.1 bits (87), Expect = 0.010
Identities = 39/136 (28%), Positives = 50/136 (36%), Gaps = 23/136 (16%)
Query: 51 GLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLK------------- 97
G P D Y + CQ + G P D + L N+I L+
Sbjct: 24 GCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWI 83
Query: 98 --NNM-------FSKFKKLKSLDLQQN-EISKIESEAFFGLNKLTTLLLQHNQIKVLTEE 147
NN+ F F L+ LDL N ++ + E F GL KL L L + L
Sbjct: 84 YSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAG 143
Query: 148 VFIYTPLLSYLRLYDN 163
VF L YL L DN
Sbjct: 144 VFGGLHSLQYLYLQDN 159
Score = 33.5 bits (75), Expect = 0.25
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 3/70 (4%)
Query: 242 CHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSS 301
C Y P+ T+ C+ +P IP D ++ L N+I L+P F + L + S
Sbjct: 29 CVCYPAPM-TVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPA--MVTLWIYS 85
Query: 302 NGIEFIDPGS 311
N I +I P +
Sbjct: 86 NNITYIHPST 95
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 73.2 bits (178), Expect = 3e-13
Identities = 79/253 (31%), Positives = 117/253 (46%), Gaps = 35/253 (13%)
Query: 66 DCQERKLVYV------LPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISK 119
DC+E +L V +P ++ + L +NKI +L + +F K+ KLK + LQ N I
Sbjct: 116 DCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRH 175
Query: 120 IESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ 179
I +AFFGL L L L HN I L +F L++L L DNP T IS
Sbjct: 176 ISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNP-------ITRISQRL 228
Query: 180 IPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDS 239
+L + + E K Q+C + QL+ R IK +S
Sbjct: 229 FTGLNSLFFLSMVNNYLEALPK--------QMC--AQMPQLNWVDLEGNR---IKYLTNS 275
Query: 240 TF--CHNYVFPIQTLDCKRKELKKVPN---NIPPDIVKLDLSYNKINQLRPKEFEDVHEL 294
TF C + + L R ++ VP + ++ +LDLS N I +L P F+D+ L
Sbjct: 276 TFLSCDS----LTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLL 331
Query: 295 KKLNLSSNGIEFI 307
+KLNLSSN + ++
Sbjct: 332 QKLNLSSNPLMYL 344
Score = 40.0 bits (92), Expect = 0.003
Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 43 NPVKRYAP----GLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKN 98
NP+ R + GL + + YL+ +++ +P L + L N+I+ L N
Sbjct: 219 NPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP----QLNWVDLEGNRIKYLTN 274
Query: 99 NMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYL 158
+ F L L L +N+I + + F L L L L N I L+ +F LL L
Sbjct: 275 STFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKL 334
Query: 159 RLYDNP 164
L NP
Sbjct: 335 NLSSNP 340
Score = 35.8 bits (81), Expect = 0.050
Identities = 28/109 (25%), Positives = 45/109 (41%), Gaps = 4/109 (3%)
Query: 45 VKRYAPGLPCDVYTYLHE-KYLDCQERKLVYVLPGW---PQDLLHMLLARNKIRTLKNNM 100
V Y LP + + + ++D + ++ Y+ L + L RN+I +
Sbjct: 241 VNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKT 300
Query: 101 FSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF 149
FS K L LDL N I+++ F L L L L N + L + F
Sbjct: 301 FSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQF 349
Score = 34.3 bits (77), Expect = 0.15
Identities = 20/76 (26%), Positives = 37/76 (48%)
Query: 88 LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEE 147
L+ N + L N F K+L+SLDL++ EI I + F + L+ + ++ +
Sbjct: 336 LSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPH 395
Query: 148 VFIYTPLLSYLRLYDN 163
V I PL + +++
Sbjct: 396 VRICMPLTDGISSFED 411
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 72.4 bits (176), Expect = 5e-13
Identities = 47/148 (31%), Positives = 71/148 (47%), Gaps = 5/148 (3%)
Query: 63 KYLDCQERKLVYVLPGWPQDLL---HMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISK 119
+YL QE L+++ DL H+ L N++R L ++F L L L N +
Sbjct: 158 QYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQG 217
Query: 120 IESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ 179
+ AF GL++LT L L +N + L E P L +LRL NPW C C L + Q
Sbjct: 218 VHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQ 277
Query: 180 IPRNRNLGNYAKCESPQEQKNKKLRQIK 207
R R + C +P E++ + LR ++
Sbjct: 278 --RARVSSSDVTCATPPERQGRDLRALR 303
Score = 38.5 bits (88), Expect = 0.008
Identities = 37/138 (26%), Positives = 51/138 (36%), Gaps = 23/138 (16%)
Query: 49 APGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLK----------- 97
AP P Y + CQ V P + L N IRTL+
Sbjct: 28 APSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTL 87
Query: 98 ----NNM-------FSKFKKLKSLDLQQN-EISKIESEAFFGLNKLTTLLLQHNQIKVLT 145
NN+ F + L+ LDL N + +E + F GL +L +L L Q+ L
Sbjct: 88 WLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLP 147
Query: 146 EEVFIYTPLLSYLRLYDN 163
+F L YL L +N
Sbjct: 148 GNIFRGLVSLQYLYLQEN 165
Score = 38.1 bits (87), Expect = 0.010
Identities = 26/72 (36%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 242 CHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSS 301
C Y P T+ C+ VP ++PP +L L N I LRP F L L L S
Sbjct: 35 CTCYSSP-PTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGS--NLLTLWLFS 91
Query: 302 NGIEFIDPGSLR 313
N + I PG+ R
Sbjct: 92 NNLSTIYPGTFR 103
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 69.7 bits (169), Expect = 3e-12
Identities = 41/130 (31%), Positives = 59/130 (45%), Gaps = 2/130 (1%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
+L H+ L N+I ++ F L L L QN ++ + AF L +L TL L N +
Sbjct: 179 NLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNL 238
Query: 142 KVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNK 201
L E L YLRL DNPW C C L + LQ + R + C PQ +
Sbjct: 239 SALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQ--KFRGSSSEVPCSLPQRLAGR 296
Query: 202 KLRQIKSEQL 211
L+++ + L
Sbjct: 297 DLKRLAANDL 306
Score = 33.1 bits (74), Expect = 0.33
Identities = 24/84 (28%), Positives = 39/84 (46%), Gaps = 1/84 (1%)
Query: 81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQN-EISKIESEAFFGLNKLTTLLLQHN 139
++L + L N + + F+ L+ LDL N ++ ++ F GL +L TL L
Sbjct: 81 RNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRC 140
Query: 140 QIKVLTEEVFIYTPLLSYLRLYDN 163
++ L +F L YL L DN
Sbjct: 141 GLQELGPGLFRGLAALQYLYLQDN 164
Score = 30.0 bits (66), Expect = 2.8
Identities = 21/67 (31%), Positives = 30/67 (44%)
Query: 242 CHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSS 301
C Y P T C ++ L+ VP IP ++ L N+I+ + F L L L S
Sbjct: 31 CVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHS 90
Query: 302 NGIEFID 308
N + ID
Sbjct: 91 NVLARID 97
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 68.9 bits (167), Expect = 5e-12
Identities = 80/271 (29%), Positives = 111/271 (40%), Gaps = 38/271 (14%)
Query: 41 GSNPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNM 100
GS PV+ GL LDC E L V P ++ M L N IR L +
Sbjct: 98 GSVPVQCLCQGLE-----------LDCDETNLRAV-PSVSSNVTAMSLQWNLIRKLPPDC 145
Query: 101 FSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRL 160
F + L+ L LQ N+I+ I AF GLN LT L L HN+I L VF L +L +
Sbjct: 146 FKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 205
Query: 161 YDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEK-EQ 219
DN +S + P L + N L ++ + LC +
Sbjct: 206 EDNH----------LSRISPPTFYGLNSLILL----VLMNNVLTRLPDKPLCQHMPRLHW 251
Query: 220 LDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVK---LDLS 276
LD + G + C N + L ++ ++ + N + K LDL
Sbjct: 252 LD----LEGNHIHNLRNLTFISCSN----LTVLVMRKNKINHLNENTFAPLQKLDELDLG 303
Query: 277 YNKINQLRPKEFEDVHELKKLNLSSNGIEFI 307
NKI L P F+D+ EL +LNLS N I+ I
Sbjct: 304 SNKIENLPPLIFKDLKELSQLNLSYNPIQKI 334
Score = 43.5 bits (101), Expect = 2e-04
Identities = 26/79 (32%), Positives = 40/79 (50%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
+L +++ +NKI L N F+ +KL LDL N+I + F L +L+ L L +N I
Sbjct: 272 NLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 331
Query: 142 KVLTEEVFIYTPLLSYLRL 160
+ + F Y L L L
Sbjct: 332 QKIQANQFDYLVKLKSLSL 350
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/81 (33%), Positives = 42/81 (51%), Gaps = 2/81 (2%)
Query: 81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQ 140
Q L + L NKI L +F K+L L+L N I KI++ F L KL +L L+ +
Sbjct: 295 QKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIE 354
Query: 141 IKVLTEEVFIYTPLLSYLRLY 161
I + + +F PL++ +Y
Sbjct: 355 ISNIQQRMF--RPLMNLSHIY 373
Score = 35.8 bits (81), Expect = 0.050
Identities = 17/40 (42%), Positives = 25/40 (62%)
Query: 270 IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDP 309
+ KL LS+N+I L+P FED+H L+ L + N + I P
Sbjct: 176 LTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISP 215
Score = 35.4 bits (80), Expect = 0.066
Identities = 26/82 (31%), Positives = 34/82 (41%), Gaps = 23/82 (28%)
Query: 252 LDCKRKELKKVPN----------------NIPPD-------IVKLDLSYNKINQLRPKEF 288
LDC L+ VP+ +PPD + KL L NKI + F
Sbjct: 111 LDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAF 170
Query: 289 EDVHELKKLNLSSNGIEFIDPG 310
++ L KL LS N I F+ PG
Sbjct: 171 RGLNSLTKLYLSHNRITFLKPG 192
Score = 33.5 bits (75), Expect = 0.25
Identities = 20/60 (33%), Positives = 32/60 (53%)
Query: 81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQ 140
++L + L+ N I+ ++ N F KLKSL L+ EIS I+ F L L+ + + Q
Sbjct: 319 KELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQ 378
>gi|40217817 slit and trk like 1 protein [Homo sapiens]
Length = 696
Score = 67.4 bits (163), Expect = 2e-11
Identities = 44/147 (29%), Positives = 65/147 (44%), Gaps = 26/147 (17%)
Query: 91 NKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFI 150
NKI++ + F L+ L N + I+ AF LNKL L+L N I L VF
Sbjct: 116 NKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQ 175
Query: 151 YTPL------------------------LSYLRLYDNPWHCTCEIETLISMLQ-IPRNRN 185
Y P+ ++ + L DNPW CTC++ +L L+ IP+N
Sbjct: 176 YVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNAL 235
Query: 186 LGNYAKCESPQEQKNKKLRQIKSEQLC 212
+G CE+P + K L + + LC
Sbjct: 236 IGRVV-CEAPTRLQGKDLNETTEQDLC 261
Score = 50.4 bits (119), Expect = 2e-06
Identities = 37/155 (23%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
DL + + N + TL F+ + L+ L+++ N I I F + KL L+L +N +
Sbjct: 424 DLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLL 483
Query: 142 KVLTEEVF---------------IYTPLLSYLR---------LYDNPWHCTCEIETLISM 177
+ L +VF +Y P+ L L+ NPW C+C I
Sbjct: 484 RSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQW 543
Query: 178 LQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC 212
+ + L + KCE+P K + ++++C
Sbjct: 544 AERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEIC 578
Score = 43.1 bits (100), Expect = 3e-04
Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 65 LDCQERKLVYVLPGWPQ--DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIES 122
++C R + + P+ ++ + L NKI +++ + F +K L LDL N I+ +E+
Sbjct: 357 MNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVEN 416
Query: 123 EAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
F L L L + N + L+ E F L YL + N
Sbjct: 417 NTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYN 457
Score = 41.2 bits (95), Expect = 0.001
Identities = 23/75 (30%), Positives = 38/75 (50%)
Query: 85 HMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVL 144
H+ L N + L N F+ F SL ++ N + +I AF GL + L + +N+IK
Sbjct: 62 HLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSF 121
Query: 145 TEEVFIYTPLLSYLR 159
++ F+ L YL+
Sbjct: 122 RKQTFLGLDDLEYLQ 136
Score = 31.2 bits (69), Expect = 1.2
Identities = 17/62 (27%), Positives = 30/62 (48%), Gaps = 2/62 (3%)
Query: 252 LDCKRKELKKVPNNIPP--DIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDP 309
+DC++K + P L L N + +L P EF + + L++ +NG+ I P
Sbjct: 40 VDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVP 99
Query: 310 GS 311
G+
Sbjct: 100 GA 101
Score = 28.5 bits (62), Expect = 8.0
Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSY---NKINQLRPKEFEDVHELKKLNLSSNGIEFID 308
LD + V NN +++ L Y N ++ L ++F + L+ LN+ N I+ I
Sbjct: 404 LDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLIL 463
Query: 309 PGS 311
PG+
Sbjct: 464 PGT 466
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 67.0 bits (162), Expect = 2e-11
Identities = 75/291 (25%), Positives = 118/291 (40%), Gaps = 37/291 (12%)
Query: 58 TYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEI 117
T HE DC KL V P ++ + L N++R L F+++ +L SLD+ N I
Sbjct: 29 TVSHE-VADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTI 87
Query: 118 SKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLY--------DNPWHCTC 169
SK+E E L L L LQHN++ L+++ F + L+ L L +NP+
Sbjct: 88 SKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQK 147
Query: 170 EIETLISMLQIPRNRNLGNYAKCESPQE--QKNKKLRQIKSEQL---CNEEEKEQLDPKP 224
+ TL + LG + E+ QE N K++ +KSE+L N K+
Sbjct: 148 NLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSN 207
Query: 225 QVSGRPP-----------------VIKPEVDSTFCHNYV-FPIQTLDCKRKELKKVPNNI 266
Q+ P + P + C I+ L +L N
Sbjct: 208 QIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTT 267
Query: 267 -----PPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGSL 312
++ LDLSYN +N + F + +L+ L N I+ + SL
Sbjct: 268 FLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSL 318
Score = 47.0 bits (110), Expect = 2e-05
Identities = 56/230 (24%), Positives = 94/230 (40%), Gaps = 17/230 (7%)
Query: 84 LHML-LARNKIRTLKNNMFSKFKKLKSLDLQQNEI-SKIESEAFFGLNKLTTLLLQHNQI 141
LH+L L +NKI ++++ FS L+ LDL NEI ++ + + GL + + L +N+
Sbjct: 409 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKY 468
Query: 142 KVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNK 201
LT F P L L L +++ S Q RN + + N
Sbjct: 469 LQLTRNSFALVPSLQRLMLRR---VALKNVDSSPSPFQPLRNLTI---------LDLSNN 516
Query: 202 KLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKK 261
+ I + L E+ E LD + R + + + L+ + +
Sbjct: 517 NIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDE 576
Query: 262 VPNNIPPDIVKL---DLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFID 308
+P + D+ +L DL N +N L F + LK LNL N I ++
Sbjct: 577 IPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVE 626
Score = 37.4 bits (85), Expect = 0.017
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 8/102 (7%)
Query: 73 VYVLPGWPQDLLHML-LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKL 131
+Y L G LH+L L N + +F +LK +DL N ++ + + F L
Sbjct: 555 IYFLKGLSH--LHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSL 612
Query: 132 TTLLLQHNQIKVLTEEVFIYTPL---LSYLRLYDNPWHCTCE 170
+L LQ N I + ++VF P L+ L + NP+ CTCE
Sbjct: 613 KSLNLQKNLITSVEKKVF--GPAFRNLTELDMRFNPFDCTCE 652
Score = 35.4 bits (80), Expect = 0.066
Identities = 24/83 (28%), Positives = 36/83 (43%), Gaps = 7/83 (8%)
Query: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNM--FSKFKKLKSLDLQQNEIS 118
+ KYL V L ++L R ++ + ++ F + L LDL N I+
Sbjct: 465 YNKYLQLTRNSFALV-----PSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIA 519
Query: 119 KIESEAFFGLNKLTTLLLQHNQI 141
I + GL KL L LQHN +
Sbjct: 520 NINDDMLEGLEKLEILDLQHNNL 542
Score = 33.5 bits (75), Expect = 0.25
Identities = 20/62 (32%), Positives = 32/62 (51%), Gaps = 1/62 (1%)
Query: 88 LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFF-GLNKLTTLLLQHNQIKVLTE 146
L N + TL ++F+ LKSL+LQ+N I+ +E + F LT L ++ N E
Sbjct: 593 LGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCE 652
Query: 147 EV 148
+
Sbjct: 653 SI 654
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 66.6 bits (161), Expect = 3e-11
Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 LPCDVYTYLHE-KYLDCQERKLVYVLPG---WPQDLLHMLLARNKIRTLKNNMFSKFKKL 107
LP +V++ L + + L ++ ++ PG +L + L N ++ L N+F L
Sbjct: 314 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANL 373
Query: 108 KSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHC 167
+++ LQ N + ++ F +N L + LQ+NQ++ L +F + L LRLYDNPW C
Sbjct: 374 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRC 433
Query: 168 TCEIETLISMLQIPRNR-NLGNYAKCESPQEQKNKKL 203
+I L + L + + R C SP + + L
Sbjct: 434 DSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 470
Score = 49.3 bits (116), Expect = 4e-06
Identities = 66/258 (25%), Positives = 106/258 (41%), Gaps = 34/258 (13%)
Query: 63 KYLDCQERKLVYVLPGWPQ---DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISK 119
+YL KL + G Q L +LL+ N++ ++ FS+ LK L L N +
Sbjct: 110 RYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEY 169
Query: 120 IESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ 179
I AF L LT L L N + ++ VF + L LRLY+N +
Sbjct: 170 IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN------------RLTD 217
Query: 180 IPRNRNLGNYAKCESPQE--QKNKKLRQIKSEQLCNEEEKEQLD-PKPQVSGRPPVIKPE 236
IP +G + + QE + ++ + N ++L +S PP I +
Sbjct: 218 IP----MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQ 273
Query: 237 VDSTFCHNYVFPIQTLDCKRKELKKVPNNI---PPDIVKLDLSYNKINQLRPKEFEDVHE 293
+ + L LK++ I P++ +L L N I+ L F ++ +
Sbjct: 274 LPQ---------LNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 324
Query: 294 LKKLNLSSNGIEFIDPGS 311
L+ L LS N I FI PG+
Sbjct: 325 LQVLILSRNQISFISPGA 342
Score = 40.4 bits (93), Expect = 0.002
Identities = 61/281 (21%), Positives = 121/281 (43%), Gaps = 32/281 (11%)
Query: 65 LDCQERKLVYVLPGWPQDL---LHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIE 121
L ++ +L + PG ++L ++ LA NK++ L +F L+SL L N++ +I+
Sbjct: 88 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 147
Query: 122 SEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPW-HCTCEIETLISMLQI 180
F + L L L N ++ + + F + L+ L L N H + + + LQ+
Sbjct: 148 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 207
Query: 181 PR---NR----NLGNYAKCESPQEQ--KNKKLRQIKSEQLCNEEEKEQLD-PKPQVSGRP 230
R NR +G + + QE + ++ + N ++L +S P
Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267
Query: 231 PVIKPEVDS----TFCHNYVFPI-----------QTLDCKRKELKKVPNNIPPDIVKLD- 274
P I ++ T N + + + L + +P+N+ ++ +L
Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327
Query: 275 --LSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGSLR 313
LS N+I+ + P F + EL++L+L +N ++ +D R
Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 368
Score = 35.0 bits (79), Expect = 0.086
Identities = 21/81 (25%), Positives = 38/81 (46%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L+ + + +N++ + F L+ L L N++ + F GL+ L +LLL NQ+
Sbjct: 85 LIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLL 144
Query: 143 VLTEEVFIYTPLLSYLRLYDN 163
+ F L L+L+ N
Sbjct: 145 QIQPAHFSQCSNLKELQLHGN 165
Score = 30.4 bits (67), Expect = 2.1
Identities = 15/62 (24%), Positives = 28/62 (45%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGS 311
++C + VP +P + + L + I +L F ++ L L + N + I PG+
Sbjct: 43 VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGA 102
Query: 312 LR 313
R
Sbjct: 103 FR 104
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 66.6 bits (161), Expect = 3e-11
Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 LPCDVYTYLHE-KYLDCQERKLVYVLPG---WPQDLLHMLLARNKIRTLKNNMFSKFKKL 107
LP +V++ L + + L ++ ++ PG +L + L N ++ L N+F L
Sbjct: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANL 367
Query: 108 KSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHC 167
+++ LQ N + ++ F +N L + LQ+NQ++ L +F + L LRLYDNPW C
Sbjct: 368 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRC 427
Query: 168 TCEIETLISMLQIPRNR-NLGNYAKCESPQEQKNKKL 203
+I L + L + + R C SP + + L
Sbjct: 428 DSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 464
Score = 49.3 bits (116), Expect = 4e-06
Identities = 66/258 (25%), Positives = 106/258 (41%), Gaps = 34/258 (13%)
Query: 63 KYLDCQERKLVYVLPGWPQ---DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISK 119
+YL KL + G Q L +LL+ N++ ++ FS+ LK L L N +
Sbjct: 104 RYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEY 163
Query: 120 IESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ 179
I AF L LT L L N + ++ VF + L LRLY+N +
Sbjct: 164 IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN------------RLTD 211
Query: 180 IPRNRNLGNYAKCESPQE--QKNKKLRQIKSEQLCNEEEKEQLD-PKPQVSGRPPVIKPE 236
IP +G + + QE + ++ + N ++L +S PP I +
Sbjct: 212 IP----MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQ 267
Query: 237 VDSTFCHNYVFPIQTLDCKRKELKKVPNNI---PPDIVKLDLSYNKINQLRPKEFEDVHE 293
+ + L LK++ I P++ +L L N I+ L F ++ +
Sbjct: 268 LPQ---------LNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 318
Query: 294 LKKLNLSSNGIEFIDPGS 311
L+ L LS N I FI PG+
Sbjct: 319 LQVLILSRNQISFISPGA 336
Score = 40.4 bits (93), Expect = 0.002
Identities = 61/281 (21%), Positives = 121/281 (43%), Gaps = 32/281 (11%)
Query: 65 LDCQERKLVYVLPGWPQDL---LHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIE 121
L ++ +L + PG ++L ++ LA NK++ L +F L+SL L N++ +I+
Sbjct: 82 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141
Query: 122 SEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPW-HCTCEIETLISMLQI 180
F + L L L N ++ + + F + L+ L L N H + + + LQ+
Sbjct: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201
Query: 181 PR---NR----NLGNYAKCESPQEQ--KNKKLRQIKSEQLCNEEEKEQLD-PKPQVSGRP 230
R NR +G + + QE + ++ + N ++L +S P
Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261
Query: 231 PVIKPEVDS----TFCHNYVFPI-----------QTLDCKRKELKKVPNNIPPDIVKLD- 274
P I ++ T N + + + L + +P+N+ ++ +L
Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321
Query: 275 --LSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGSLR 313
LS N+I+ + P F + EL++L+L +N ++ +D R
Sbjct: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 362
Score = 35.0 bits (79), Expect = 0.086
Identities = 21/81 (25%), Positives = 38/81 (46%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L+ + + +N++ + F L+ L L N++ + F GL+ L +LLL NQ+
Sbjct: 79 LIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLL 138
Query: 143 VLTEEVFIYTPLLSYLRLYDN 163
+ F L L+L+ N
Sbjct: 139 QIQPAHFSQCSNLKELQLHGN 159
Score = 30.4 bits (67), Expect = 2.1
Identities = 15/62 (24%), Positives = 28/62 (45%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGS 311
++C + VP +P + + L + I +L F ++ L L + N + I PG+
Sbjct: 37 VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGA 96
Query: 312 LR 313
R
Sbjct: 97 FR 98
>gi|27436867 slit and trk like 4 protein [Homo sapiens]
Length = 837
Score = 64.3 bits (155), Expect = 1e-10
Identities = 72/309 (23%), Positives = 121/309 (39%), Gaps = 85/309 (27%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L N+++ L+ + F + L+ L N I IE AF L+KL L+L N I
Sbjct: 109 LKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLIS 168
Query: 143 VLTEEVFIYTPL------------LSY------------LRLYDNPWHCTCEIETLISML 178
L + +F + L L Y L+L DNPW+C+C++ L + L
Sbjct: 169 FLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWL 228
Query: 179 Q-IPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC------------------------- 212
+ +P N +G A CE+P + + L++ ++LC
Sbjct: 229 ENMPYNIYIGE-AICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTP 287
Query: 213 ----NEEEKEQLDPKP-------QVSG--------------------RPPVIKPEVDSTF 241
+ +L KP ++SG R P + P F
Sbjct: 288 NGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCF 347
Query: 242 CHNYVFPI-QTLDCKRKELKKVPNNIPPDI--VKLDLSYNKINQLRPKEFEDVHELKKLN 298
C + + +++C+ K ++ + IP + KL ++ N I + +F D L L+
Sbjct: 348 CKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLH 407
Query: 299 LSSNGIEFI 307
L SN I I
Sbjct: 408 LGSNQITVI 416
Score = 61.6 bits (148), Expect = 9e-10
Identities = 51/203 (25%), Positives = 82/203 (40%), Gaps = 54/203 (26%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
DLLH L N+I +K ++F L+ L L N+I ++ E F GL+ L L L++N I
Sbjct: 404 DLLH--LGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
Query: 142 KV---------------------------------------LTEEVFIYTPL-------- 154
K L F+Y P+
Sbjct: 462 KEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQ 521
Query: 155 -LSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC- 212
L+ + L NPW CTC++ L ++ + + KCE+P + N +L+ +K+E LC
Sbjct: 522 SLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCP 581
Query: 213 ---NEEEKEQLDPKPQVSGRPPV 232
N+ P P ++ P+
Sbjct: 582 KLLNKPSAPFTSPAPAITFTTPL 604
Score = 51.2 bits (121), Expect = 1e-06
Identities = 34/110 (30%), Positives = 53/110 (48%), Gaps = 6/110 (5%)
Query: 54 CDVYTYLHEKYLDCQERKLVY----VLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKS 109
C + + Y++C E+ VY + P W + H+ N + L N F F S
Sbjct: 30 CSCVSVENVLYVNC-EKVSVYRPNQLKPPW-SNFYHLNFQNNFLNILYPNTFLNFSHAVS 87
Query: 110 LDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLR 159
L L N++ IE AF GL+ L L L +N++K+L + F+ L YL+
Sbjct: 88 LHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQ 137
Score = 41.6 bits (96), Expect = 0.001
Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 6/103 (5%)
Query: 65 LDCQERKLVYVLPGWPQDL----LHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
++CQE+ + + P+ L LH+ N I+ + + F+ F+ L L L N+I+ I
Sbjct: 359 VNCQEKNIQSMSELIPKPLNAKKLHV--NGNSIKDVDVSDFTDFEGLDLLHLGSNQITVI 416
Query: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
+ + F L L L L NQI+ L E+F L YL L N
Sbjct: 417 KGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYN 459
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 63.9 bits (154), Expect = 2e-10
Identities = 56/207 (27%), Positives = 79/207 (38%), Gaps = 57/207 (27%)
Query: 53 PCDVYTYLHEKYLDCQERKLVYVLPGWPQD------------------------LLHMLL 88
PCD + DC R L V PG+P + L + L
Sbjct: 22 PCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWL 81
Query: 89 ARNKIRTLKNNMFSKFKKLKSLDLQQN------------------------EISKIESEA 124
A N+IRT+ + LKSLDL N E++ I +A
Sbjct: 82 AHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDA 141
Query: 125 FFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIE-----TLISMLQ 179
F L L +L L HN++ L E F LS+L++ +NP+ CTC I L + +
Sbjct: 142 FRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVS 201
Query: 180 IPRNRNLGNYAKCESPQEQKNKKLRQI 206
IP N+ C SP K L ++
Sbjct: 202 IPEQDNIA----CTSPHVLKGTPLSRL 224
Score = 39.3 bits (90), Expect = 0.005
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 247 FPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEF 306
+ Q DC ++L+ VP P ++ L LS N++ L F +V L+ L L+ N I
Sbjct: 29 YGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRT 88
Query: 307 IDPGSL 312
+ G+L
Sbjct: 89 VAAGAL 94
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 63.9 bits (154), Expect = 2e-10
Identities = 56/207 (27%), Positives = 79/207 (38%), Gaps = 57/207 (27%)
Query: 53 PCDVYTYLHEKYLDCQERKLVYVLPGWPQD------------------------LLHMLL 88
PCD + DC R L V PG+P + L + L
Sbjct: 22 PCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWL 81
Query: 89 ARNKIRTLKNNMFSKFKKLKSLDLQQN------------------------EISKIESEA 124
A N+IRT+ + LKSLDL N E++ I +A
Sbjct: 82 AHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDA 141
Query: 125 FFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIE-----TLISMLQ 179
F L L +L L HN++ L E F LS+L++ +NP+ CTC I L + +
Sbjct: 142 FRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVS 201
Query: 180 IPRNRNLGNYAKCESPQEQKNKKLRQI 206
IP N+ C SP K L ++
Sbjct: 202 IPEQDNIA----CTSPHVLKGTPLSRL 224
Score = 39.3 bits (90), Expect = 0.005
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 247 FPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEF 306
+ Q DC ++L+ VP P ++ L LS N++ L F +V L+ L L+ N I
Sbjct: 29 YGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRT 88
Query: 307 IDPGSL 312
+ G+L
Sbjct: 89 VAAGAL 94
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 63.5 bits (153), Expect = 2e-10
Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 1/144 (0%)
Query: 81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQ 140
++L ++ L +N+I+++ F L+ L L N+I ++ ++F L KL L L +N+
Sbjct: 110 ENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNR 169
Query: 141 IKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ-IPRNRNLGNYAKCESPQEQK 199
I L F + + LRL N HC CEI L +L+ + N A CE P+ +
Sbjct: 170 ITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQ 229
Query: 200 NKKLRQIKSEQLCNEEEKEQLDPK 223
+ + I E+L E + +P+
Sbjct: 230 GRSVATITPEELNCERPRITSEPQ 253
Score = 41.6 bits (96), Expect = 0.001
Identities = 25/54 (46%), Positives = 30/54 (55%)
Query: 110 LDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
LDL+ N I +I+ AF L L TLLL +NQIK + F L YL LY N
Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN 120
Score = 34.7 bits (78), Expect = 0.11
Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 251 TLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPG 310
T+ C L+ VP + P LDL +N+I +++P F + L L L++N I+ I G
Sbjct: 46 TVRCMHLLLEAVPA-VAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSG 104
Query: 311 S 311
+
Sbjct: 105 A 105
Score = 33.1 bits (74), Expect = 0.33
Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 3/68 (4%)
Query: 249 IQTLDCKRKELKKVPNNIPPDIVKLDLSY---NKINQLRPKEFEDVHELKKLNLSSNGIE 305
+ TL ++K++P+ D+ L Y N+I + + F+ + L++L L N IE
Sbjct: 88 LNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIE 147
Query: 306 FIDPGSLR 313
+DP S +
Sbjct: 148 TLDPDSFQ 155
Score = 29.3 bits (64), Expect = 4.7
Identities = 14/40 (35%), Positives = 25/40 (62%)
Query: 272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGS 311
+L L +N+I L P F+ + +L++L L +N I + PG+
Sbjct: 138 QLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGT 177
>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
Length = 958
Score = 63.2 bits (152), Expect = 3e-10
Identities = 45/167 (26%), Positives = 72/167 (43%), Gaps = 24/167 (14%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L NK+ L+++ F + L+ L + N IS IE AF L+ L L+L N +
Sbjct: 131 LRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLS 190
Query: 143 VLTEEVFIYTPL------------LSY------------LRLYDNPWHCTCEIETLISML 178
L +F + PL L Y L+L +NPW+C+CE+ +L L
Sbjct: 191 SLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWL 250
Query: 179 QIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQ 225
L CE+P + L ++ ++LC + +PQ
Sbjct: 251 DSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQ 297
Score = 61.6 bits (148), Expect = 9e-10
Identities = 59/231 (25%), Positives = 86/231 (37%), Gaps = 56/231 (24%)
Query: 59 YLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEIS 118
YL E Y+ R G DLLH L N+I +++ F L+ L L N I
Sbjct: 415 YLTENYIAVVRRTDFLEATGL--DLLH--LGNNRISMIQDRAFGDLTNLRRLYLNGNRIE 470
Query: 119 KIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYL-------------------- 158
++ E F+GL L L LQ+N I+ + F P L L
Sbjct: 471 RLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTL 530
Query: 159 ----------------------------RLYDNPWHCTCEIETLISMLQIPRNRNLGNYA 190
L+DNPW CTC+I + ++ + L +
Sbjct: 531 LRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEV 590
Query: 191 KCESPQEQKNKKLRQIKSEQLCNEEEKEQLD-PKP---QVSGRPPVIKPEV 237
C++P++ +R IKSE LC + + P P QV R + P V
Sbjct: 591 ICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAV 641
Score = 47.0 bits (110), Expect = 2e-05
Identities = 30/100 (30%), Positives = 52/100 (52%), Gaps = 6/100 (6%)
Query: 65 LDCQERKLVYVL----PGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
+ C+ R ++ + P +P + H+LL+ N + L N F + L L N I I
Sbjct: 63 VSCENRGIISLSEISPPRFP--IYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDI 120
Query: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRL 160
E+ AF GL L L L +N++++L ++ F+ L YL++
Sbjct: 121 ETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQV 160
Score = 47.0 bits (110), Expect = 2e-05
Identities = 35/101 (34%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 65 LDCQERKLVYV--LPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIES 122
++CQERK+ + L P + M L N I ++ F + L L L N IS I+
Sbjct: 391 VNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQD 450
Query: 123 EAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
AF L L L L N+I+ L+ E+F L YL L N
Sbjct: 451 RAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYN 491
Score = 32.7 bits (73), Expect = 0.43
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 249 IQTLDCKRKELKKVPNNIPP--DIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEF 306
I T+ C+ + + + PP I L LS N +N+L P EF + L+L SN I+
Sbjct: 60 ILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQD 119
Query: 307 IDPGS 311
I+ G+
Sbjct: 120 IETGA 124
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 62.8 bits (151), Expect = 4e-10
Identities = 69/293 (23%), Positives = 115/293 (39%), Gaps = 64/293 (21%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + + N + LK + F + L+ L N I+ IE AF LN+L L+L N I+
Sbjct: 114 LKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIE 173
Query: 143 VLTEEVFIYTPL------------LSY------------LRLYDNPWHCTCEIETLISML 178
L +F + PL L Y L+L DN W C C++ L + L
Sbjct: 174 SLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWL 233
Query: 179 QIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEE--KEQLDPKP------------ 224
+ +++ C SP K L ++K E +C +E DP
Sbjct: 234 ENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSIND 293
Query: 225 -----------QVSGRPPVIKPEV--DSTFCHNYVFPIQ-----------TLDCKRKELK 260
++ + P + P + ST PI + C+ + ++
Sbjct: 294 SRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIE 353
Query: 261 KVPNNIPP--DIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGS 311
+ + PP + KL L+ N I+ L + + L+ L+L +N IE ++ GS
Sbjct: 354 SLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGS 406
Score = 57.8 bits (138), Expect = 1e-08
Identities = 45/179 (25%), Positives = 69/179 (38%), Gaps = 50/179 (27%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
++LH L N+I L+ F +L+ L L N ++K+ F GL+ L L L++N I
Sbjct: 390 EMLH--LGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAI 447
Query: 142 K------------------------VLTEEVFIYTP------------------------ 153
K VL +F P
Sbjct: 448 KEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLD 507
Query: 154 LLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC 212
LL+ + L DNPW C+C++ L +Q + + C SP K+L+ + SE LC
Sbjct: 508 LLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILC 566
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 62.4 bits (150), Expect = 5e-10
Identities = 39/130 (30%), Positives = 60/130 (46%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
+L ++L+ N I L +F ++L L L N ++ + F L+KL L L NQ+
Sbjct: 314 NLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQL 373
Query: 142 KVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNK 201
L E +F L L L+ NPW C C + L + LQ +R L C P K +
Sbjct: 374 TTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQ 433
Query: 202 KLRQIKSEQL 211
+ + +QL
Sbjct: 434 VVPALNEKQL 443
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/102 (34%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 76 LPGWPQ-------DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGL 128
L G PQ L + L N I L +FS+ L+ L LQ+N I+ + F L
Sbjct: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
Query: 129 NKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCE 170
LT L LQ N ++VL +F +TP L L L N E
Sbjct: 265 GNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAE 306
Score = 39.7 bits (91), Expect = 0.003
Identities = 55/241 (22%), Positives = 90/241 (37%), Gaps = 56/241 (23%)
Query: 80 PQDLLHML-------LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLT 132
P++L H L L+ N + L +F K L+ L L N IS++ + F L L
Sbjct: 185 PEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244
Query: 133 TLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKC 192
L LQ N I L +F L++L L N ML++ L + C
Sbjct: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWN-------------MLRV-LPAGLFAHTPC 290
Query: 193 ESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTL 252
+ +L + + TF H + +++L
Sbjct: 291 LVGLSLTHNQLETV------------------------------AEGTFAH--LSNLRSL 318
Query: 253 DCKRKELKKVPNNIPPD---IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDP 309
+ +P I D +VKL L N + L P F+++ +L+ L+LS N + +
Sbjct: 319 MLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPE 378
Query: 310 G 310
G
Sbjct: 379 G 379
Score = 28.5 bits (62), Expect = 8.0
Identities = 23/114 (20%), Positives = 42/114 (36%)
Query: 50 PGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKS 109
P PC + + + C + +L V P +++ TL+ F L
Sbjct: 18 PAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTK 77
Query: 110 LDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
+ ++ + +AF GL +L L + + L+ +F L L L N
Sbjct: 78 VVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFN 131
>gi|12597641 leucine rich repeat containing 19 [Homo sapiens]
Length = 370
Score = 61.2 bits (147), Expect = 1e-09
Identities = 43/155 (27%), Positives = 67/155 (43%), Gaps = 22/155 (14%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L NK+ L NN F L+ L++ +N I I+ AF GLNKL L L N+I+
Sbjct: 75 LTELYLIENKVTILHNNGFGNLSSLEILNICRNSIYVIQQGAFLGLNKLKQLYLCQNKIE 134
Query: 143 VLTEEVFI----------YTPLLSYL-----------RLYDNPWHCTCEIETLISMLQIP 181
L +VF+ L+SYL LY N W+C+C + L + L
Sbjct: 135 QLNADVFVPLRSLKLLNLQGNLISYLDVPPLFHLELITLYGNLWNCSCSLFNLQNWLNTS 194
Query: 182 R-NRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEE 215
N C P ++ ++ + + C+ +
Sbjct: 195 NVTLENENITMCSYPNSLQSYNIKTVPHKAECHSK 229
Score = 30.0 bits (66), Expect = 2.8
Identities = 16/37 (43%), Positives = 20/37 (54%)
Query: 272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFID 308
+L L NKI QL F + LK LNL N I ++D
Sbjct: 125 QLYLCQNKIEQLNADVFVPLRSLKLLNLQGNLISYLD 161
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 60.8 bits (146), Expect = 1e-09
Identities = 43/153 (28%), Positives = 69/153 (45%), Gaps = 5/153 (3%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
+L + L N IRTL ++ L+ LDL N ++++ F GL L +L L+ N++
Sbjct: 117 NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRL 176
Query: 142 KVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ--IPRNRNLGNYAKCESPQEQK 199
+ L F L L++ DNPW C C + ++ R L A C P+E +
Sbjct: 177 QNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLA-CTLPKELR 235
Query: 200 NKKLRQIKSEQL--CNEEEKEQLDPKPQVSGRP 230
K +R + E C++ E E + G P
Sbjct: 236 GKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPP 268
Score = 30.8 bits (68), Expect = 1.6
Identities = 17/54 (31%), Positives = 30/54 (55%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIE 305
+DC L VP ++P L L NK++ L F ++ L++L+LS+N ++
Sbjct: 52 VDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLD 105
>gi|194272183 G protein-coupled receptor 124 [Homo sapiens]
Length = 1338
Score = 60.5 bits (145), Expect = 2e-09
Identities = 46/159 (28%), Positives = 66/159 (41%), Gaps = 25/159 (15%)
Query: 80 PQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHN 139
P + +LL+ NKI L+N F L+ LDL+ N IS ++ AF GL +L L L +N
Sbjct: 83 PNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNN 142
Query: 140 QIKVLTEEVFIYTPLLSYLRLYDNPWH------------------------CTCEIETLI 175
+I LT E F P L L + N + C C + L+
Sbjct: 143 RIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLL 202
Query: 176 SMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNE 214
Q R+ L + C P + L ++ QLC E
Sbjct: 203 PWAQ-NRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCE 240
Score = 33.5 bits (75), Expect = 0.25
Identities = 20/49 (40%), Positives = 27/49 (55%)
Query: 263 PNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGS 311
P +P V L LS NKI LR F + L+KL+L +N I + PG+
Sbjct: 79 PGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGA 127
Score = 32.3 bits (72), Expect = 0.56
Identities = 15/42 (35%), Positives = 25/42 (59%)
Query: 269 DIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPG 310
++ +LDLS N+I L + F+ + L +LN+S N + PG
Sbjct: 133 ELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPG 174
Score = 30.8 bits (68), Expect = 1.6
Identities = 16/33 (48%), Positives = 23/33 (69%)
Query: 272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGI 304
KLDL N I+ ++P F + ELK+L+LS+N I
Sbjct: 112 KLDLRNNIISTVQPGAFLGLGELKRLDLSNNRI 144
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 60.5 bits (145), Expect = 2e-09
Identities = 46/168 (27%), Positives = 74/168 (44%), Gaps = 8/168 (4%)
Query: 65 LDCQERKLVYVLPG--WPQDLLHML-LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIE 121
L + +L ++ P W + L L L N++ L + L++LDL NE+S +
Sbjct: 258 LSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALH 317
Query: 122 SEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISML--Q 179
F L +L L L++N + L+ ++F +P L L L N W C C + L +
Sbjct: 318 PATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDW 377
Query: 180 IPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVS 227
+ R L + +C P + K L + +QL N DP P S
Sbjct: 378 HSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQN---GSCADPSPSAS 422
Score = 46.2 bits (108), Expect = 4e-05
Identities = 29/84 (34%), Positives = 46/84 (54%), Gaps = 2/84 (2%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEI--SKIESEAFFGLNKLTTLLLQHN 139
+LL++ L N+IR L N F++ KL+ L+L NE+ S + F L L++L+L N
Sbjct: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSAN 239
Query: 140 QIKVLTEEVFIYTPLLSYLRLYDN 163
++ L +F + P L L L N
Sbjct: 240 NLQHLGPRIFQHLPRLGLLSLRGN 263
Score = 40.8 bits (94), Expect = 0.002
Identities = 18/41 (43%), Positives = 28/41 (68%)
Query: 272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGSL 312
+LDL YN+I L PK FE + L++L L +N ++ + PG+L
Sbjct: 87 RLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTL 127
Score = 40.4 bits (93), Expect = 0.002
Identities = 34/108 (31%), Positives = 49/108 (45%), Gaps = 8/108 (7%)
Query: 61 HEKYLDCQERKLVYV-----LPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQN 115
H ++L C R L V LP P D+L L N I + F + +L+ LDLQ N
Sbjct: 35 HPQHLLCTNRGLRVVPKTSSLPS-PHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYN 93
Query: 116 EISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
+I + + F L++L L L +N ++ L PL LY N
Sbjct: 94 QIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTL--APLRKLRILYAN 139
Score = 40.4 bits (93), Expect = 0.002
Identities = 26/81 (32%), Positives = 37/81 (45%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L N ++ L + +KL+ L NEIS++ +F GL L L L N +
Sbjct: 109 LEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALG 168
Query: 143 VLTEEVFIYTPLLSYLRLYDN 163
L + VF L YL L N
Sbjct: 169 ALPDAVFAPLGNLLYLHLESN 189
>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
sapiens]
Length = 345
Score = 60.5 bits (145), Expect = 2e-09
Identities = 44/149 (29%), Positives = 66/149 (44%), Gaps = 4/149 (2%)
Query: 65 LDCQERKLVYVLPGWPQDLLHML---LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIE 121
L+ L + PG L H+ L +N + +L++ +F +L+ LDL N IS +
Sbjct: 79 LNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLP 138
Query: 122 SEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ-I 180
+ LT L +Q NQ++ L + P + L L DN W C C + L L+
Sbjct: 139 TSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKF 198
Query: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSE 209
L + CESP K K L +I E
Sbjct: 199 VYKGGLTDGIICESPDTWKGKDLLRIPHE 227
Score = 43.5 bits (101), Expect = 2e-04
Identities = 21/60 (35%), Positives = 35/60 (58%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGS 311
+DC ++ L ++P+++PP L L N+I+ L F V L LNLS+N + + PG+
Sbjct: 34 VDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGA 93
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 59.7 bits (143), Expect = 3e-09
Identities = 34/103 (33%), Positives = 56/103 (54%), Gaps = 2/103 (1%)
Query: 110 LDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTC 169
L LQ N+I+ I AF L KL L + +NQ+++LT+ VF L L +NPW C C
Sbjct: 257 LYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDC 316
Query: 170 EIETLISMLQ-IPRNRNLGNYAKCESPQEQKNKKLRQIKSEQL 211
I+ + L+ IP + N+ + C+ P++ + +R++ L
Sbjct: 317 SIKWVTEWLKYIPSSLNVRGF-MCQGPEQVRGMAVRELNMNLL 358
Score = 44.3 bits (103), Expect = 1e-04
Identities = 63/285 (22%), Positives = 105/285 (36%), Gaps = 50/285 (17%)
Query: 52 LPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRT---------------- 95
L C ++ C ER L V G P+ + + L N+I
Sbjct: 34 LACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTV 93
Query: 96 -LKNNMFSKF-----KKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF 149
L N +F K ++ L LQ+N I I A L KL L L N I + E
Sbjct: 94 YLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDG 153
Query: 150 IYTPLLSYLRLYDNPWHCTCEIETL---ISMLQIPRNRNLGNYAKCESPQEQKNKKLRQI 206
+ +S L+ + H + L + L++ NR + I
Sbjct: 154 AFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENR------------------IAVI 195
Query: 207 KSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNI 266
N E+L V G K + TF H + ++ R L P ++
Sbjct: 196 SDMAFQNLTSLERLI----VDGNLLTNKGIAEGTFSH--LTKLKEFSIVRNSLSHPPPDL 249
Query: 267 P-PDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPG 310
P +++L L N+IN + F ++ +L++L++S+N + + G
Sbjct: 250 PGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQG 294
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 59.3 bits (142), Expect = 4e-09
Identities = 31/89 (34%), Positives = 46/89 (51%)
Query: 86 MLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLT 145
+ LA N++ L + F +L+ L LQ+N I +E +A GL+ L L L NQ+ ++
Sbjct: 127 LYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTIS 186
Query: 146 EEVFIYTPLLSYLRLYDNPWHCTCEIETL 174
E L LRL +NPW C C + L
Sbjct: 187 REALQPLASLQVLRLTENPWRCDCALHWL 215
Score = 45.1 bits (105), Expect = 8e-05
Identities = 27/81 (33%), Positives = 39/81 (48%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L N +R L+ F +L L L N + + S AF GL +L L L NQ+
Sbjct: 76 LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135
Query: 143 VLTEEVFIYTPLLSYLRLYDN 163
L + F++ P L L L +N
Sbjct: 136 RLLDFTFLHLPRLQELHLQEN 156
Score = 38.1 bits (87), Expect = 0.010
Identities = 20/63 (31%), Positives = 32/63 (50%)
Query: 251 TLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPG 310
T++C L+ VP IPP L L N I +L P + L++L L +N + ++ G
Sbjct: 33 TVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAG 92
Query: 311 SLR 313
+ R
Sbjct: 93 AFR 95
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 59.3 bits (142), Expect = 4e-09
Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 4/121 (3%)
Query: 88 LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEE 147
++ N ++ F LK L + +++S IE AF GL L L L HN + L +
Sbjct: 225 MSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHD 284
Query: 148 VFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ--IPRNRNLGNYAKCESPQEQKNKKLRQ 205
+F L L L+ NPW+C C+I L L+ IP N +C +P + + L +
Sbjct: 285 LFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTC--CGRCHAPMHMRGRYLVE 342
Query: 206 I 206
+
Sbjct: 343 V 343
Score = 54.3 bits (129), Expect = 1e-07
Identities = 62/243 (25%), Positives = 99/243 (40%), Gaps = 46/243 (18%)
Query: 67 CQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFF 126
C R L V G P + ++ L N I+ ++ + F L+ L L +N I +IE AF
Sbjct: 61 CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN 120
Query: 127 GLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNL 186
GL L TL L N + V+ F Y L L L +NP IE++ S
Sbjct: 121 GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNP------IESIPS---------- 164
Query: 187 GNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYV 246
YA P + L ++K + +E E L
Sbjct: 165 --YAFNRVPSLMR-LDLGELKKLEYISEGAFEGL-------------------------- 195
Query: 247 FPIQTLDCKRKELKKVPNNIP-PDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIE 305
F ++ L+ +K +PN P + +L++S N ++RP F + LKKL + ++ +
Sbjct: 196 FNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVS 255
Query: 306 FID 308
I+
Sbjct: 256 LIE 258
Score = 40.0 bits (92), Expect = 0.003
Identities = 20/58 (34%), Positives = 30/58 (51%)
Query: 254 CKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPGS 311
C R+ L +VP IP + L+L N I ++ F +H L+ L L N I I+ G+
Sbjct: 61 CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGA 118
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,754,784
Number of Sequences: 37866
Number of extensions: 608916
Number of successful extensions: 3766
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 184
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 2385
Number of HSP's gapped (non-prelim): 1203
length of query: 313
length of database: 18,247,518
effective HSP length: 102
effective length of query: 211
effective length of database: 14,385,186
effective search space: 3035274246
effective search space used: 3035274246
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.